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Sample records for terapia con i131

  1. Control system of liquid effluents generated in treatment with I-131; Sistema de control de efluentes liquidos generados en el tratamiento con I-131

    Energy Technology Data Exchange (ETDEWEB)

    Garcia M, T.; Ruiz C, M. A.; Angeles C, A.; Ramirez S, R., E-mail: teodoro.garcia@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    In recent years, nuclear medicine has developed greatly in our country and around the world. Techniques for both medical diagnosis and therapy have increased the use of radiopharmaceuticals, notably the I-131. In Mexico there are around 150 nuclear medicine establishments authorized by the Comision Nacional de Seguridad Nuclear y Salvaguardias. Most of these establishments do not have an appropriate facility for the treatment of radioactive liquid effluents, to ensure compliance with the concentration limits established in the regulations. The Instituto Nacional de Investigaciones Nucleares (ININ) developed and implemented successfully, a control system of radioactive effluents (named SACEL) from a nuclear medicine facility. This system ensures an effective compliance with regulations and also better management and control of these radioactive effluents. Calculations and design of SACEL were made with respect to I-131, because is one of the most commonly used in radiotherapy and medical diagnostics, besides its half-life is greater in relation to other radionuclides. SACEL is comprised of four storage tanks and decay and a fifth tank for measuring the concentration of I-131 and later discharge to the drain; these tanks are connected to an automated system that controls the effluents passage. The calculation to determine the volume of the tanks was carried out according to the demand that has the hospital, to the maximum activity being poured in effluents and time required to decay. In this paper the design and installation of SACEL system, in addition to functioning as a facility that enables the Hospital meet the required standards is presented. Dose calculations performed with MCNPX and the methodology used in the calibration of the detection system is also presented. (Author)

  2. Evaluation of detectors for blood bioanalysis in Lu-177 and I-131 therapies for bone marrow dosimetry; Avaliacao de detectores para bioanalise de sangue em terapias com Lu-177 and I-131 para dosimetria de medula ossea

    Energy Technology Data Exchange (ETDEWEB)

    Degenhardt, Amilie Louize

    2016-10-01

    The measures traceability is mandatory for minimizing uncertainties in internal dosimetry for radiopharmaceuticals clinical studies and ensures the quality of the standard. Equipment should have resolution and efficiency compatible with radionuclides energies and, additionally, be able to quantify variations in human bodies' activities samples since the initial administration near the minimum residual activities. For testing three equipment (ionization chamber Capintec 25R, sodium iodine scintillator LTI Genesys Gamma-1 and high hyperpure germanium detector Canberra), they were prepared Lu-177 and I-131 radiation sources simulating patient's blood samples activities by adopting the following hypothesis: (1) initial activities according the Brazilian protocols; (2) blood volume in the whole body (5.3 L for adult men and 1.4 L for 5 years-old children); (3) effective half-lives (1.61 h and 42.9 h for Lu-177 bi-exponential adjustment and 15.7 h for I-131 mono-exponential adjustment); (4) sampling between 30 min and 168 h; (v) blood density adjustments. The standard sources were measured in the secondary standard ionization chamber Centronics IG11 at the Laboratorio Nacional de Metrologia das Radiacoes Ionizantes. The Capintec ionization chamber efficiencies ranged, respectively for I-131 and Lu-177, between (111.58±0.02)% and (102.27±0.01)% and HPGe semiconductor detector efficiencies ranged, respectively, between (89.40±0.03)% and (87.80±0.04)%. For the NaI detector, when the Lu-177 sources were positioned inside the detector the efficiencies ranged between (12.66±0.01)% and (11.54± 0.07)% and when the sources were positioned at 5 cm and 10 cm from the detector the efficiencies decreased to less than 5%. For I-131 sources positioned inside the detector, the efficiencies ranged between (29.76±0.21)% and (30.20±0.04)% and they decreased to less than 5% when they were positioned at 5 cm and 10 cm from the detector (deviation greater than 95

  3. Terapias alternativas con animales para niños con necesidades especiales

    OpenAIRE

    Cea-Chueca, Aihnoa

    2014-01-01

    El presente trabajo de fin de grado consiste en la realización de un análisis y descripción de la literatura acerca de las distintas terapias animales, destinadas a niños con necesidades especiales: cómo y por qué surgieron, en qué consisten las terapias, cómo podemos utilizarlas, etc. Las terapias alternativas con animales se conocen como una alternativa terapéutica, donde se utiliza a un animal como co-terapeuta para poder desarrollar diferentes capacidades de los niños con necesidades espe...

  4. Treatment of solitary, autonomously-functioning, non-toxic thyroid nodules with I131 Adenema tiroideo autónomo no tóxico tratamiento con I131

    Directory of Open Access Journals (Sweden)

    Federico Uribe Londoño

    1991-03-01

    Full Text Available

    Fifteen euthyroid patients (14 women and 1man with solitary autonomously functioning non-toxic thyroid nodules (AFTN were treated with high doses of I131 (mean 19.2 mCi. Diagnosis was made by I131 thyroid scan and triiodothyronine suppression test. The size of the nodule was determined by thyroid ecography both before and after treatment. Evaluation of thyroid function was performed clinically and by T3 T4 and TSH determinations before therapy and during follow.up. AII patients had complete suppression of the surrounding thyroid parenchyma. Two cases of hypothyroidism were found in the first two years of follow-up. We have no explanation for this fact since extranodular thyroid tissue was suppressed and the patients were receiving oral triiodothyronine during radioidine treatment. The nodules decreasedin size In 9 of 13 patients followed (average decrease 45% and disappeared in other 2. our findings suggest that solitary non-toxic AFTN should be treated with I131 particularly if complete suppression of the surrounding thyroid tissue is found. If complete disappearance of the nodule is considered desirable surgical removal must be performed.

    Se trataron 14 mujeres y un hombre, con adenomas tiroideos solitarios funcionalmente autónomos, no tóxicos, con I131 a una dosis promedio de 19.2 mCi. La gamagrafía tiroidea demostró hipercaptación del nódulo con supresión total del resto de la glándula. El tamaño del nódulo se determinó por medio de ecografía tiroidea antes y después del tratamiento, y su autonomía por la prueba de supresión con triyodotironina. El estado tiroideo se puso de presente clínicamente y por la medición de T3, T 4 y TSH en el plasma, antes de la terapia con el radiofármaco y durante la evolución postratamiento. En dos

  5. Tratamiento de la Enfermedad de Graves con I131: Primeros casos en la Unidad de Endocrinología Pediátrica del Hospital Nacional Cayetano Heredia, Lima-Perú: Case Report.

    Directory of Open Access Journals (Sweden)

    Javier Ernesto SÁNCHEZ POVIS

    2006-01-01

    Full Text Available Objetivo: Describir la respuesta al tratamiento con I131 y sus complicaciones, en niños y adolescentes con enfermedad de Graves. Material y Métodos: Se estudiaron retrospectivamente las historias clínicas de los pacientes con diagnóstico de enfermedad de Graves y que recibieron tratamiento con I131 atendidos hasta 1999 en la Unidad de Endocrinología Pediátrica del Hospital Nacional Cayetano Heredia. Se registraron datos demográficos, peso tiroideo, captación de yodo, dosis de I131 recibida y evolución clínica y de función tiroidea. Resultados: Se incluyeron 13 pacientes: 1 varón y 12 mujeres. El peso glandular promedio obtenido fue 47,56 +10,70 gramos. La dosis inicial calculada fue 3,92 + 0,95 mCi, con un total de 4,47 + 1,66 mCi y tiempo medio de seguimiento de 2,76 años. Diez pacientes recibieron 1 sola dosis, 2 pacientes dos dosis y un paciente tres dosis, remitiendo el 100%. Los pacientes que recibieron una sola dosis, mostraron remisión del cuadro en 13,13 semanas y el tiempo promedio de remisión de toda la muestra fue 24,62 semanas. La prevalencia de hipotiroidismo a los 6 meses de iniciado el tratamiento fue 66,66%, y 83,33% a las 257 semanas. Conclusión: I131 fue 100% eficaz en el tratamiento de la enfermedad de Graves de los niños y adolescentes en esta pequeña serie de casos. (Rev Med Hered 2006;17:8-14.

  6. Beneficios de la terapia con resistómetro inspiratorio en los pacientes con esclerosis multiple frente a terapias respiratorias convencionales

    OpenAIRE

    Martín Sánchez, Carlos

    2016-01-01

    [ES] La Universidad de Salamanca (USAL) a través del programa de Doctorado en Oncología Clínica realiza un estudio con ASPRODES, la Asociación Salmantina de Esclerosis Múltiple (ASDEM) y la Asociación Zamorana de Esclerosis Múltiple (AZDEM) para llevar a cabo un estudio experimental con el fin de analizar las ventajas que la terapia respiratoria con resistómetro inspiratorio puede aportar a los pacientes con Esclerosis Múltiple frente a las técnicas de fisioterapia respiratoria convencional. ...

  7. Terapia regenerativa con plasma rico en plaquetas en pacientes con quemaduras

    Directory of Open Access Journals (Sweden)

    María del Carmen Franco Mora

    2015-10-01

    Full Text Available Se realizó un estudio comparativo, longitudinal y prospectivo de 60 adultos con quemaduras profundas, atendidos en el Hospital General docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde febrero de 2013 hasta igual mes de 2014, para evaluar la efectividad de la terapia regenerativa con plasma rico en plaquetas para la cicatrización de estas lesiones. La muestra fue dividida en 2 grupos de 30 integrantes cada uno: a los del primero se les aplicó plasma rico en plaquetas y a los del segundo sulfadiazina de plata. Se utilizaron las frecuencias absolutas y el porcentaje como medidas de resumen para variables cualitativos, así como la media aritmética y la desviación estándar para las cuantitativas. Con el proceder aplicado la cicatrización se completó en un tiempo menor, de manera que se demostró la efectividad de esta alternativa terapéutica en relación con el tratamiento convencional

  8. Internal dosimetry for the radiological protection of the patient in the therapy with I-131; Dosimetria interna para la proteccion radiologica del paciente en la terapia con I-131

    Energy Technology Data Exchange (ETDEWEB)

    Deluca, G.M.; Rojo, A.M. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 (C1429BNP), Buenos Aires (Argentina)]. e-mail: gdeluca@cae.arn.gov.ar

    2006-07-01

    In the patients with differentiated thyroid cancer (CADIT) subjected to therapy with radiopharmaceuticals should be considered the possible risk of sharp depression of the bone marrow like consequence of the intolerance to the quantity of administered activity. The manifestation of the myelotoxicity can limit in a substantial way the future treatments and to deteriorate the predict of resolution of the illness. In this work it shows the physical-mathematical mark of a methodology for the estimated absorbed dose in bone marrow based in the MIRD scheme whose objective is to protect the one patient of the noxious and undesirable effects of the internal radiotherapy in organs that are not target of the same one. The formalism incorporates specific information of the patient and also peculiar characteristics of the internal therapy in patient with CADIT. The considerations are the following ones: (1) the main organ to protect is the bone marrow: (2) the accumulated activity, in bone marrow, it is obtained starting from measurements in blood: (3) the used isotope almost exclusively in this type of therapies is the {sup 131}I; (4) it is used as radiopharmaceutical at the {sup 131}INa that it is characterized to be a simple, inorganic and small molecule: (5) the statistical incidence of the CADIT is bigger in women than in men. It is explained for that it was selected the formalism that is presented, the principles on which it is sustained which are their reaches and their limitations. They are also presented future innovations that can be implemented to effects of improving the estimates. The work is framed inside the thematic of the medical applications of open radioactive sources and it constitutes a contribution to the invigoration of the internal therapy with radiopharmaceuticals. This is due to that the methodology of dose estimation presented supplements with a theoretical biophysics base the protocols of empiric prescription broadly used in this practice. For these reasons, the dosimetric information obtained, adjusted to each concrete case, it contributes to improve the radiological protection of the patient. (Author)

  9. Introducción a la terapia asistida con animales: tipologías de terapia en España

    OpenAIRE

    García Martín, Carmen

    2011-01-01

    Se hace una revisión teórico-bibliográfica sobre la terapia asistida con animales, centrándose en animales como perros, caballos y delfines, en los diferentes ámbitos de intervención en España, incluyendo datos recogidos sobre los resultados de este tipo de terapia en algunas asociaciones del país

  10. Juego serio para terapias de rehabilitación motora y cognitiva con realidad virtual

    OpenAIRE

    Pinilla Giménez, Inés

    2017-01-01

    Este Trabajo Fin de Grado consiste en el desarrollo de un juego serio con realidad virtual para su uso como complemento en terapias de rehabilitación de pacientes que hayan sufrido un accidente cerebrovascular con posteriores secuelas motoras y/o cognitivas. Primero estudiaremos el ictus, junto con sus causas, los tipos existentes y sus distintas secuelas. A continuación, expondremos la importancia de la rehabilitación en este tipo de pacientes, y cómo los videojuegos de realidad virtual p...

  11. Radioactive Iodine (I-131) Therapy for Hyperthyroidism

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Radioactive Iodine (I-131) Therapy Radioiodine therapy is a nuclear ... thyroid cancer. When a small dose of radioactive iodine I-131 (an isotope of iodine that emits ...

  12. Efecto de la terapia física y terapia ocupacional en una paciente con Síndrome de West: Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Herminio Teófilo Camacho-Conchucos

    2014-10-01

    Full Text Available Se presenta el caso de una niña de 12 años con diagnóstico de Síndrome de West. Asistió a consulta médica por primera vez a los 8 meses de edad, sus convulsiones se acentuaron a la edad de dos años y medio, lo que agravó el retraso psicomotor. Inicio terapia física y terapia ocupacional, empleando técnicas de neurodesarrollo y marcos de referencia respectivamente. A la presentación del caso se observaron avances favorables en aspectos cualitativos más que cuantitativos.

  13. Software for dosimetry hypothyroid patients treated with I131 pick up and using probe gamma camera; Software para la dosimetria de pacientes hipertiroideos tratados con 131I utilizando sonda de captacion y gammacamara

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez Felstrom, D.; Luis simon, J.; Reyes Garcia, R.; Derecho Torres, P.; Herrador Cordoba, M.

    2015-07-01

    In this communication the process recently implemented in our hospital for pre and post treatment of patients treated with I-131 in benign diseases of the thyroid gland internal dosimetry is described. We have developed a proprietary software that facilitates the process of dosimetry. Through scans Planar or pictures Spect be determines the mass of the gland thyroid. In function of the mass, is calculated by Monte Carlo the media power absorbed by disintegration of the I-131 in said gland endocrine. (Author)

  14. Costo-beneficio de la terapia en ambiente húmedo versus terapia tradicional: el caso de un paciente con úlcera en la extremidad inferior

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    Blanca Lilia Reyes-Rocha

    Full Text Available Actualmente, ha cobrado relevancia el uso de la terapia húmeda en la cura de las heridas crónicas; sin embargo, persiste el uso de la terapia tradicional como técnica para lograr la cicatrización de las mismas. El caso que presentamos tiene como propósito determinar el costo-beneficio del empleo de apósitos de cura en ambiente húmedo versus cura tradicional en un paciente con úlcera en la extremidad inferior. Los resultados muestran que el coste es mayor con la terapia en ambiente húmedo; sin embargo, el periodo de cicatrización de la herida es menor en comparación con el tiempo de cicatrización que conlleva la cura tradicional; esto redunda en un beneficio para el paciente al alcanzar su recuperación en un menor tiempo. Estos hallazgos permiten proponer hipótesis para estudios posteriores bajo otro diseño metodológico, a fin de generar evidencia científica que coadyuve en la mejora de los procesos de atención en beneficio de la población con este tipo de padecimiento.

  15. Terapia con células madre en cirrosis = Stem cell therapy in cirrhosis

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    Londoño Agudelo, Jessica María

    2011-12-01

    Full Text Available En este artículo se presenta una revisión de la literatura sobre las células madre como terapia para la cirrosis hepática, con énfasis en describir la situación científica actual y las implicaciones clínicas de los avances. Se ha propuesto la terapia celular en cirrosis por la escasez de donantes de hígado y las complicaciones derivadas de la terapia inmunosupresora. Las células madre se pueden obtener de diferentes fuentes como el blastocisto, la médula ósea e incluso hepatocitos maduros; pero la capacidad de proliferación y diferenciación de cada uno de estos tipos celulares es distinta y, entre otras consideraciones, es lo que va a definir su utilidad clínica final. En la literatura se encuentran varios estudios en modelos animales y en seres humanos que evalúan la seguridad y factibilidad de esta técnica en cuanto a la mejoría de la fibrosis, la capacidad de diferenciación y replicación celulares y algunos parámetros clínicos. Los resultados, aunque alentadores, se deben interpretar con cuidado. En conclusión, antes de aceptar esta modalidad terapéutica se requieren estudios de mejor calidad y con homogeneidad metodológica porque su uso aún es controversial.

  16. Envejecimiento y Alzheimer. Terapias asistidas con animales domésticos

    OpenAIRE

    Herrera García, Tamara

    2015-01-01

    Este trabajo pretende dar a conocer, las diferentes teorías en cuanto al envejecimiento, una revisión teórica en cuanto a la enfermedad del Alzheimer, sus fases y los diferentes tipos de demencias, y por último las terapias asistidas con animales domésticos como medio de mejorar la autonomía en personas enfermas de Alzheimer. Los profesionales dedicados a ello tienen la tarea de prestarles una atención individualizada, puesto que son un colectivo de personas no homogéneo. Es importante destac...

  17. Efectividad de la terapia floral de Bach en pacientes con alcoholismo crónico

    OpenAIRE

    Contrera Vega, Noraima; Cedeño Rodríguez, Enriqueta; Vázquez Sánchez, Monserrat

    2012-01-01

    Se realizó una intervención terapéutica en 15 pacientes con alcoholismo crónico, pertenecientes al Grupo Básico de Trabajo No. 3 del Policlínico Docente "Armando García Aspurú", de Santiago de Cuba, desde junio de 2008 hasta febrero de 2009, a fin de evaluar la efectividad de la terapia floral de Bach en el tratamiento de dichos pacientes, para lo cual se aplicó primero un esquema terapéutico general y luego individual. Se emplearon la media aritmética para cuantificar los datos, la desviació...

  18. Adherencia a la terapia compresiva en los pacientes con úlceras venosas

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    María del Carmen Folguera Álvarez

    Full Text Available Objetivo: Analizar la bibliografía publicada en relación con los factores que influyen en la adherencia al tratamiento de la terapia compresiva en las personas con úlceras venosas. Método: Se ha realizado una revisión bibliográfica, consultando PubMed, BioMed Central, Library Cochrane Plus, CUIDEN, LILACS, IBECS, IME, SciELO, CINAHL, desde enero del 2003 a mayo de 2013. Resultados: Se han encontrado dieciséis documentos que cumplen los criterios de inclusión. Existen factores que influyen en la adherencia al tratamiento relacionados con los pacientes, profesionales e instituciones. Conclusiones: Se debe considerar el carácter crónico de las úlceras venosas y realizar las intervenciones, teniendo en cuenta las preferencias, conocimientos y habilidades tanto propias como de los pacientes.

  19. Recurrent thyrotoxicosis after I-131 induced hypothyroidism

    International Nuclear Information System (INIS)

    Liu, L.; Borowski, G.D.; Shtasel, P.; Rose, L.I.

    1984-01-01

    The first clinically and biochemically documented case of recurrent thyrotoxicosis after I-131 induced hypothyroidism in a patient with Graves' disease is reported. Two months after the administration of 9.2 mCi of I-131, the subject developed hypothyroidism. One month later, the patient became euthyroid. Then, nine months following ablation, the patient again developed thyrotoxicosis. A second dose of I-131 of 12.5 mCi was required to finally produce permanent hypothyroidism. This case illustrates the recurrence of hypothyroidism after what had seemed to have been adequate I-131 radiation

  20. Terapia trombolítica en pacientes con infarto agudo de miocardio en Cienfuegos

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    Lázaro Abilio Hernández Rodríguez

    2014-03-01

    Full Text Available Fundamento: el tratamiento trombolítico practicado a menos de dos horas, tras el inicio del infarto tiene resultados similares a la reperfusión mecánica. Objetivo: describir aspectos relevantes de la terapia trombolítica en pacientes con infarto agudo de miocardio con elevación del segmento ST en Cienfuegos. Métodos: estudio descriptivo, prospectivo, en 225 pacientes egresados (vivos y fallecidos desde el 1o de abril de 2012 al 31 marzo de 2013, de la Unidad de Cuidados Integrales del Corazón y la Unidad de Cuidados Intensivos Polivalentes, del Hospital Dr. Gustavo Aldereguía Lima. Las variables estudiadas se obtuvieron de la revisión de las historias clínicas e incluyeron: variables demográficas y clínicas, tiempos de demora, sitio, motivo de exclusión y nivel de prioridad para la trombolisis. Resultados: la media de edad superó los 60 años. Predominaron los hombres, hipertensos y de alto riesgo según la escala GRACE. El 29,7 % de los pacientes no recibió terapia trombolítica, debido mayormente al factor tiempo y la mayoría (82,3 % se trató en el Hospital. Las medianas de los tiempos de demora: síntomas-puerta, puerta-droga y síntomas-droga fueron 90, 35 y 140 minutos respectivamente. Conclusiones: la trombolisis extrahospitalaria acorta el tiempo total de isquemia, pero pocos pacientes se beneficiaron de ella. Los retrasos para la terapia trombolítica en Cienfuegos continúan por encima de los estándares requeridos.

  1. Efectos de las terapias ecuestres en personas con parálisis cerebral

    Directory of Open Access Journals (Sweden)

    Augusto Jiménez de la Fuente

    2017-12-01

    Full Text Available El objetivo del artículo es revisar la literatura científica existente a fin de comprobar los efectos de las terapias ecuestres en personas con parálisis cerebral. Se realizó una revisión bibliográfica en las bases de datos de Medline (PubMed, Dialnet, Scopus, Sportdiscus y Web of Science, estableciendo como criterios de inclusión para seleccionar los estudios clínicos por revisar que estos hubieran sido publicados entre 2001 y 2016, en castellano o inglés. Asimismo, se rechazaron aquellos en los que los sujetos recibieran una combinación de tratamientos farmacológicos. Se revisaron un total de 68 artículos, de los cuales 20 cumplieron los criterios de inclusión. Se analizaron la población objeto de estudio, el tipo de tratamiento, la temporalización y los resultados obtenidos. En general, se observan beneficios significativos en el uso de las terapias ecuestres como tratamiento para personas con parálisis cerebral.

  2. Terapias asistidas con animales: síntomas y funcionalidad en trastornos del espectro autista y demencia senil

    OpenAIRE

    González Rosauro, Belén

    2012-01-01

    En este trabajo se realiza un recorrido teórico acerca de los principales aspectos que engloba la terapia asistida con animales, una modalidad terapéutica con una base histórica sólida que actualmente goza de una popularidad en creciente desarrollo. Los numerosos estudios realizados han sido capaces de verificar las grandes ventajas que supone realizar una terapia de este tipo como complemento a otros tratamientos principales, además de los cuantiosos beneficios de los animales para el ser hu...

  3. Asociación de colelitiasis y terapia de reemplazo de testosterona en un paciente con hipogonadismo primario

    OpenAIRE

    S. Squarza; U.G. Rossi; P. Torcia; M. Cariati

    2018-01-01

    Resumen: Tratamos a un niño de 16 años de edad con hipogonadismo primario debido a la anorquia bilateral, que presentó cálculos biliares en la vesícula biliar con una leve dilatación del árbol biliar intrahepático. La histología de los cálculos biliares confirmó la naturaleza de colesterol de los mismos. El niño fue tratado desde la infancia con terapia de reemplazo de testosterona. Sugerimos una posible correlación entre la terapia de reemplazo de testosterona y la presencia de cálculos bili...

  4. Evaluación preliminar en un modelo animal de la terapia con larvas de Lucilia sericata para el tratamiento de la leishmaniasis cutánea

    OpenAIRE

    Jazzmin Arrivillaga; Jaime Rodríguez; Milagros Oviedo

    2008-01-01

    Introducción. La terapia con larvas ha sido ampliamente utilizada para el tratamiento de lesiones ulcerativas de la piel; existen registros de enfermedades, como podopatía diabética, osteomielitis y úlceras varicosas, en las cuales el uso de la terapia con larvas ha promovido la cicatrización de la lesión en presencia de patógenos bacterianos resistentes a los antibióticos convencionales. Objetivo. Realizar una prueba piloto de terapia con larvas de Lucilia sericata sobre lesiones cutáneas...

  5. Terapia asistida con animales y cuidados de enfermería : una revisión de la literatura más reciente

    OpenAIRE

    Salazar Calleja, Alma

    2016-01-01

    Introducción. La terapia asistida con animales en el ámbito sanitario se remonta al siglo XI. Con el paso del tiempo y la aparición de nueva evidencia científica que avala el gran número de beneficios derivados de sus efectos terapéuticos, dichas terapias han adquirido cierta popularidad. Objetivos.El objetivo principal de este trabajo es conocer los resultados de la terapia asistida con animales; y como objetivo secundario determinar cuál es el papel de la enfermería. Métodos. Para analizar ...

  6. I-131 and thyroid-associated ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, Aase Krogh; Nygaard, Birte; Feldt-Rasmussen, Ulla

    2000-07-01

    Objective: Radioiodine (I-131) used to obtain euthyroidism in thyrotoxic patients is suspected of having a worsening or provoking effect on thyroid-associated ophthalmopathy (TAO), an autoimmune disease closely related to Graves' disease. Design: This review summarises the existing literature and describes risk factors influencing the course of TAO including thyroid function, cigarette smoking and treatment of Graves' hyperthyroidism especially I-131 therapy. Conclusion: It is recommended that patients who may be at a greater risk of worsening ophthalmopathy are considered when choosing the modality of therapy of hyperthyroidism and also in deciding whether prophylactic systemic glucocorticoid treatment is indicated.

  7. Cuanta más psicología, mejor: eficacia para dejar de fumar de la terapia cognitiva conductual intensiva y de los parches de nicotina combinados con terapia cognitiva conductual intensiva y menos intensiva

    OpenAIRE

    Fernández Arias, Ignacio Gabino; García-Vera, María Paz; Sanz, Jesús

    2014-01-01

    Para comparar la eficacia para dejar de fumar de la terapia cognitiva conductual intensiva (TCC/I), la TCC/I con parches de nicotina (TCC/I+PN) y la terapia cognitiva conductual no intensiva con parches de nicotina (TCC/NI+PN) se realizó un estudio experimental de medidas repetidas con 235 fumadores adultos asignados aleatoriamente a uno de esos tres tratamientos. Entre los pacientes que completaron el tratamiento (n = 152) la TCC/I+PN mostró tasas de abstinencia a los 6 meses y al año, mayor...

  8. Eficacia de la Terapia Psicoeducativa Motivacional Breve Dual (TPMB-D) en pacientes hospitalizados con trastorno por uso de sustancias y patología dual

    OpenAIRE

    Benito Delegido, Ana María

    2015-01-01

    El Hospital Provincial de Castellón adaptó la Terapia Psicoeducativa Motivacional Breve (efectiva en pacientes con trastorno por uso de sustancias (TUS) en Unidad de Desintoxicación Hospitalaria) para pacientes con patología dual (PD)(TPMB-D). Este estudio experimental doble ciego usó dos grupos aleatorios para evaluar la eficacia de la TPMB-D comparada con terapia ocupacional (TO) en pacientes hospitalizados con TUS y con PD. Completaron el estudio 163 pacientes, de los que el 68.7% prese...

  9. Propuesta de mejora de habilidades sociales en niños con discapacidad intelectual mediante la terapia asistida por animales

    OpenAIRE

    Bermejo Lorenzo, Julia

    2015-01-01

    Este Trabajo de Fin de Grado se centra en la aplicación práctica de un programa de mejora de la Educación Socioemocional, utilizando como herramienta innovadora la Terapia Asistida con Animales de Compañía, aplicándose a un caso real de un alumno con Parálisis Cerebral y Discapacidad Intelectual asociada. Los objetivos de las actividades están centrados en el desarrollo de la autoconciencia, el autocontrol, la conciencia social y la toma de decisiones responsables. Mediante este proyecto se p...

  10. Terapia Familiar y Adicciones. Un enfoque práctico con resultados prácticos

    Directory of Open Access Journals (Sweden)

    Miguel Alberto Ramírez Villaseñor

    2001-01-01

    Full Text Available En el presente trabajo, se describe el fenómeno dela adicción cómo un problema familiar. No sólo por cómo la familia es afectada, sino por la manera en que ésta participa, no en la génesis de la misma sino en el mantenimiento de las conductas consideradas como parte de la enfermedad. Por lo mismo, se describen características que la familia presenta descritas en la literatura especializada de terapia familiar (Stanton y Todds, 1988 y que han sido corroboradas en la práctica clínica qué contradicen muchas de las ideas populares sobre familias de adictos tales cómo: desintegración familiar, descuido familiar, deseos de llamar la atención, madres que trabajan y otros. Las características mencionadas en la literatura son: Dependencia química multigeneracional (generalmente alcohol. Propensión al juego y a mirar T.V. Conspicuamente no esquizofrénica. Fuertes relaciones externas como refugio generalmente después de un conflicto. Ilusión de independencia mayor gracias a la subcultura de la droga. Expresión del conflicto mas primitivo. Alianzas entre miembros y subsistemas explícitas. Prácticas de crianza y necesidades “simbióticas”. Predominio de temas relacionados con la muerte y muertes prematuras, inesperadas y repentinas dentro de la familia. Y disparidad cultural padres-hijos.

  11. Eficacia de la Terapia Psicoeducativa Motivacional Breve Dual (TPMB-D) en pacientes hospitalizados con trastorno por uso de sustancias y patología dual

    OpenAIRE

    Rubio Perlado, Begoña; Benito, Ana; Juan Porcar, María; Francés, Sonia; Real, Matías; Haro, Gonzalo

    2015-01-01

    Introducción: El término patología dual (PD) se refiere a la comorbilidad de los trastornos por uso de sustancias (TUS) con trastornos mentales graves. Se asocia con peores resultados de tratamiento que cada uno de estos trastornos por separado, por lo que es importante desarrollar terapias específicas para estos pacientes. En este sentido, el Hospital Provincial de Castellón adaptó la Terapia Psicoeducativa Motivacional Breve (efectiva en pacientes con TUS en Unidad de Desinto...

  12. Cuanta más psicología, mejor: eficacia para dejar de fumar. De la terapia cognitiva conductual intensiva y de los parches de nicotina combinados con terapia cognitiva conductual intensiva y menos intensiva

    Directory of Open Access Journals (Sweden)

    Ignacio Gabino Fernández Arias

    2014-01-01

    Full Text Available Para comparar la eficacia para dejar de fumar de la terapia cognitiva conductual intensiva (TCC/I, la TCC/I con parches de nicotina (TCC/I+PN y la terapia cognitiva conductual no intensiva con parches de nicotina (TCC/NI+PN se realizó un estudio experimental de medidas repetidas con 235 fumadores adultos asignados aleatoriamente a uno de esos tres tratamientos. Entre los pacientes que completaron el tratamiento (n= 152 la TCC/I+PN mostró tasas de abstinencia a los 6 meses y al año, mayores que la TCC/NI+PN, mientras que la TCC/I mostró tasas de abstinencia que no eran significativamente diferentes de las de los otros dos tratamientos. Estos resultados sugieren que los parches de nicotina se deberían utilizar siempre con una terapia cognitiva conductual lo más intensiva posible y que la utilización de esta última terapia en solitario debería gozar de mayor relevancia en las guías clínicas para dejar de fumar.

  13. Significado de calidad de vida en pacientes con terapia de hemodiálisis: un estudio fenomenológico

    Directory of Open Access Journals (Sweden)

    Leslie Herbias Herbias

    2016-03-01

    Full Text Available La calidad de vida es uno de los aspectos importantes a abordar en pacientes en hemodiálisis. Objetivo: Comprender el significado de calidad de vida para personas que son sometidas a tratamiento de sustitución renal con hemodiálisis. Metodología: Estudio cualitativo fenomenológico descriptivo. Se realizaron entrevistas en profundidad a 12 personas en hemodiálisis. Las entrevistas fueron grabadas y transcritas textualmente. El análisis se realizó de acuerdo a Streubert, se resguardaron criterios de rigor y se contó con la aprobación del Comité científico de la Facultad de Enfermería de la Universidad Andrés Bello. Resultados: Calidad de vida fue descrita a través de tres categorías comprensivas: Salud, Familia y Actividades de la vida diaria, que involucra ámbitos físicos, psicológicos y sociales. Los participantes significan la calidad de vida cómo Seguir viviendo, ya que producto de la terapia pueden continuar con su vida. Conclusiones: Comprender lo que significa calidad de vida permite ampliar la mirada, fortalecer el vínculo con la familia y considerar lo crucial de esta terapia en la vida de las personas en hemodiálisis. Se sugiere fortalecer la relación enfermera-paciente con el fin de otorgar cuidados seguros y de calidad a los usuarios y sus familias.

  14. Radiation exposure in I-131 iodine therapy

    International Nuclear Information System (INIS)

    Friedrich, W.

    1985-01-01

    In the past five years, the applied I-131 radioactivity quantity has doubled with a constant number of beds. In 1984, it was 925 GBq (25 Ci). Despite this development, no changes in the professional radiation exposure were made out. The evaluation shows a dose smaller than 0.04 man Sv/TBq (0.16 man rem/Ci) of I-131 applied. This value is below the traceability limit of the film badges. The incorporation load of the personnel (27 members) was determined by monthly body counter measurements. Only in one measurement thyroid gland activity of 5 kBq (140 nCi) was detected. Most measurements did not show any incorporation; and the few positive results were below 0.74 kBq (20 nCi). The environmental load due to unfiltered release from patients' rooms was determined at the fence of the nuclear research plant. The maximum was 0.24 mSv/a thyroid gland dose of a small child in 1982 taking into account the measured 90% partion of organic compound iodine. The waste water is decayed following chemical treatment in storage tanks. (orig./HP) [de

  15. Estrategias para mejorar la reperfusión con terapia fibrinolítica en infarto con elevación del ST-T

    OpenAIRE

    Jerjes-Sánchez D, Carlos; Sosa del Angel, Edgar; García Sosa, Anabel; Reyes Cerezo, Esteban; Garza Ruiz, Angel

    2003-01-01

    Las estrategias de reperfusión en la fase temprana del infarto con elevación del ST-T tienen como principal objetivo restituir y mantener la perfusión tisular. La terapia fibrinolítica puede considerarse como el tratamiento estándar por su accesibilidad y efectividad para disminuir daño miocárdico y mortalidad. La principal imperfección de esta estrategia de reperfusión radica en el porcentaje no despreciable de fracaso terapéutico y reoclusión por fenómenos de resistencia y retrombosis. La t...

  16. Radiopharmaceutical potential of I-131 labelled diazepam

    International Nuclear Information System (INIS)

    Yurt, F.; Unek, P.; Asikoglu, M.; Baggi, S.; Erener, G.; Ozkilic, H.; Uluc, F.; Tuglular, I.

    1998-01-01

    In this study, diazepam is a derivative of the 1.4 benzodiazepine family that the most widely used drug as anticonvulsant agent has been labeled with I-131, as a new radiopharmaceutical and its radiopharmaceutical potential has been determined. Labeling of diazepam has been performed by iodogen method and optimum labeling conditions have been determined. Optimum reaction conditions are 1 mg for iodogen amount; 1-5 mg for diazepam amount, 15-20 minutes for reaction time and room temperature for reaction temperature. Specific activity of labeled compound was 0,15 Ci/mmol level. N-octanol/water ratio was found 1.9 for 131 IDZ ( 131 I labeled diazepam). In vivo experiments have been carried out to determine radiopharmaceutical potentials of labeled compound. Biodistribution studies on rats showed that 131 IDZ have accumulated in kidneys, liver, lungs and brain tissues. Scintigraphic results taken with gamma camera on rabbits agree with biodistribution results of rats. (author)

  17. Terapia combinada de homeopatía y Su Jok en pacientes con herpes zóster

    Directory of Open Access Journals (Sweden)

    Jobana Carmenza Forero Perdomo

    2015-03-01

    Full Text Available Se realizó un estudio cuasi-experimental, de intervención terapéutica, en 60 pacientes con herpes zóster, que asistieron a la consulta de Dermatología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde julio del 2012 hasta marzo del 2014, a fin de determinar la efectividad de la terapia combinada de homeopatía y Su Jok, para lo cual se utilizaron pruebas estadísticas paramétricas y no paramétricas. Los pacientes fueron asignados aleatoriamente a 2 grupos; en uno se aplicó el tratamiento convencional (grupo de control y en el otro, la terapéutica alternativa (grupo de estudio Se emplearon los remedios homeopáticos Sulphur, Apis mellifica, Rhus toxicodendron y Daphne mezereum; las semillas de cardo santo para estimular los puntos de correspondencia de Su Jok y los medicamentos aciclovir, dipirona y difenhidramina. En la serie predominaron las féminas (38,3 %, los grupos etarios de 45-64 años (58,3 % y la forma clínica intercostal (38,3 %; asimismo, los síntomas más frecuentes fueron el dolor, prurito y ardor, con primacía del primero (51,6 %. La terapia combinada de Su Jok y homeopatía mostró resultados similares (83,3 % a los obtenidos con la convencional (86,6 % y produjo mínimos efectos adversos (6,6 %

  18. Modelo de intervención de Terapia Ocupacional Comunitaria con Personas Mayores en el Municipio de Alcobendas

    OpenAIRE

    Viedma, María José de

    2014-01-01

    V Jornadas de actualización en terapia ocupacional: Formación continuada en terapia ocupacional, celebradas en la Universidad Rey Juan Carlos campus de Alcorcón en 2014. Fisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física

  19. Atendiendo a las Variadas Problemáticas de los Cuidadores Familiares de Personas con Demencia: Aportaciones de la Terapia Cognitivo-Conductual y de la Terapia de Aceptación y Compromiso

    Directory of Open Access Journals (Sweden)

    Andrés Losada

    2015-01-01

    Full Text Available Cuidar a un familiar mayor con demencia se asocia con consecuencias emocionales negativas para los cuidadores. En este trabajo se describe una terapia cognitivo-conductual (TCC y otra de aceptación y compromiso (ACT que han sido diseñadas para reducir el malestar emocional de los cuidadores. El objetivo de la TTC es modificar creencias y pensamientos disfuncionales relacionados con el cuidado y entrenar a los cuidadores en el aumento de la frecuencia de actividades gratificantes. Incluye además entrenamiento en relajación y en habilidades para pedir ayuda. A través de la terapia ACT se trabaja la identificación del patrón personal de evitación experiencial y la alternativa de la aceptación de emociones, pensamientos y sensaciones, se ayuda al cuidador a identificar sus valores y las barreras para la acción coherente con ellos y se trabaja para incrementar la motivació del cuidador para comprometerse con sus valores y llevar a cabo acciones coherentes con dichos valores.

  20. Aspectos histopatológicos y receptores hormonales en mucosa endometrial de mujeres posmenopáusicas con terapia hormonal

    Directory of Open Access Journals (Sweden)

    Victoria Valer

    2005-03-01

    Full Text Available Objetivos: Determinar si existe correlación directa entre la terapéutica hormonal administrada en mujeres posmenopaúsicas, el comportamiento de los receptores estrogénicos y progesterónicos en la mucosa endometrial y los cuadros histológicos más frecuentes de patologías endometriales secundarias al tratamiento. Material y Métodos: Estudio prospectivo, longitudinal de 40 mujeres posmenopaúsicas entre los 43 y 60 años con síndrome climatérico, administrándoles 2 mg de 17 beta estradiol y 1 mg de acetato de noretisterona por día, en forma continua y por vía oral. Se realizó una biopsia endometrial basal y otra postratamiento al octavo mes. Las muestras fueron procesadas para estudio histopatológico e inmunohistoquímico para receptores estrogénicos y progesterónicos. Resultados: La menarquia se presentó a una edad promedio de 13,2 años y la menopausia fisiológica entre 42 y 52 años, con una edad promedio de 46,4 años. La sintomatología climatérica mejoró notablemente con la terapia hormonal. El estudio histopatológico de mucosa endometrial basal mostró 10% de hiperplasia simple y 90% de atrofia; postratamiento, todos los casos presentaron atrofia. Los receptores se expresaron en la mucosa endometrial basal: RE (+ 12,5%, RP (++ 12,5%; postratamiento RE (+ 2,5%, RE (+++ 2,5% y RP(+ 2,5%. Conclusiones: La terapia en dosis diarias vía oral de 2 mg de 17 beta estradiol y 1 mg de acetato de noretisterona disminuye la sintomatología climatérica y produce atrofia endometrial en las pacientes con hiperplasia previa. Existe disminución estadísticamente significativa entre la primera muestra basal y la del octavo mes de la expresión de receptores estrogénicos y progesterona.

  1. Contribución de la terapia psicomotriz al progreso de niños con discapacidades

    Directory of Open Access Journals (Sweden)

    Marguerite Heron-Flores

    2018-01-01

    Full Text Available Introducción. Independiente a la edad, la psicomotricidad incide en el desarrollo de las personas, por lo que es un aspecto de interés para profesionales de la salud, la rehabilitación, la educación y los servicios sociales. Objetivo. Determinar en qué medida un programa psicomotor de intervención, implementado en niños con diferentes discapacidades, contribuye a la mejoría de dichos trastornos psicomotores y a su adaptación en el medio ambiente. Materiales y métodos. Se implementó un diseño pre y post evaluación enmarcado en el paradigma de Mixed Methods, con programa de intervención durante 7 meses y con 13 participantes con diferentes niveles de trastornos psicomotores. Los instrumentos de medida fueron test psicomotores cuantitativos, hojas de registro de observación y cuestionarios y entrevistas cualitativas a las familias. Resultados. Tras la aplicación del programa se producen mejoras en la evolución psicomotriz de los niños en el esquema corporal, en la coordinación dinámica general, en la estructuración espacial, en la motricidad fina y en la adaptación del niño al medio ambiente. Conclusiones. Es necesario que las terapias utilizadas en personas con discapacidades presenten una visión holística de la persona, atendiendo tanto los aspectos motores como psicológicos.

  2. La terapia de vacío como alternativa terapéutica en quemaduras con exposición ósea

    Directory of Open Access Journals (Sweden)

    Álvaro J. Bernal-Martínez

    Full Text Available Introducción y Objetivos: En determinados casos el desbridamiento quirúrgico de las quemaduras de espesor total genera defectos de cobertura con exposición de hueso. Cuando se trata de pacientes con gran superficie corporal quemada, la disponibilidad de tejidos para llevar a cabo la reconstrucción de estos defectos es limitada. La introducción de la terapia de vacío en el tratamiento de este tipo de lesiones supone una alternativa para estos pacientes. Pacientes y Método: Presentamos 2 casos de pacientes con quemaduras extensas y profundas en las extremidades inferiores y exposición ósea. En ambos aplicamos terapia de vacío. Resultados: Logramos el cierre completo de las heridas tras obtener una cobertura total del hueso con tejido de granulación y posterior injerto cutáneo. Conclusiones: Consideramos que la terapia de vacío es una alternativa útil que actúa de forma segura estimulando el cierre de la herida y minimizando las necesidades de tratamiento quirúrgico en quemaduras de espesor total con exposición ósea.

  3. Infecciones pulmonares en pacientes con VIH 20 años después de la terapia antirretroviral combinada. ¿Qué ha cambiado?

    Directory of Open Access Journals (Sweden)

    Johanna Osorio

    Full Text Available Introducción: Antes del año 1996, la infección por el virus de la inmunodeficiencia humana (VIH era considerada una condición fatal; sin embargo, con la introducción de la terapia antirretroviral combinada, se transformó en una enfermedad crónica con gran incremento en su expectativa de vida. A pesar de esta terapia, existen una serie de complicaciones a las que los individuos con VIH están expuestos. El pulmón es el órgano más comúnmente afectado. Las infecciones oportunistas como la neumonía por Pneumocystis jirovecii , el compromiso pulmonar asociado a histoplasmosis, tuberculosis y micobacterias no tuberculosas, entre otras, aún son condiciones que amenazan a esta población. Objetivo: Esta revisión pretende abordar los cambios en el diagnóstico, pronóstico y epidemiología de los pacientes con VIH e infecciones pulmonares, luego de la introducción de la terapia antirretroviral combinada. Metodología: Se revisaron las bases de datos electrónicas MEDLINE (pubmed, EMBASE, SciELOy LILACS. Se incluyeron revisiones sistemáticas, ensayos clínicos aleatorizados, estudios controlados, series de tiempo, « antes y después » , estudios observacionales desde el año 1995 hastadiciembre de 2014, así como datos epidemiológicos de la OMS. Conclusiones: Después de casi 20 años de su introducción, la terapia antirretroviral combinadaha modificado la historia natural de la infección por VIH, con disminución en la frecuencia depresentación y mortalidad relacionada con la mayoría de los patógenos que comprometen eltracto respiratorio

  4. Terapia asistida con perros en niños con autismo revisión sistemática

    OpenAIRE

    Isaza Narváez, Ana Milena; Muñoz Chilito, Doumer Adrian

    2013-01-01

    Introducción: El autismo es un trastorno temprano y masivo del desarrollo en el cual se afecta la interacción social, el desarrollo del lenguaje, se presentan rituales y estereotipias. Hay evidencia que la interacción con un perro está asociada con efectos positivos en la salud del niño, lo cual se extiende al terreno terapéutico donde la compañía del perro estimula habilidades comunicativas para conectarse con el mundo exterior y romper el aislamiento que lo hace refractario a formas convenc...

  5. Terapia de restauración vascular con plataformas biorreabsorbibles. La cuarta revolución

    Directory of Open Access Journals (Sweden)

    Darío Echeverri

    2014-07-01

    Full Text Available Con la aprobación y concesión del Registro Sanitario 201300 4713 del 25 de febrero de 2013, con vigencia hasta el año 2023, por parte del Instituto Nacional de Vigilancia de Medicamentos y Alimentos como órgano oficial del Ministerio de Salud y Protección Social de Colombia, a la plataforma biorreabsorbible Absorb BVS®, con el nombre de stent medicado biorreabsorbible, la introducción de estas plataformas al portafolio terapéutico del cardiólogo intervencionista para el tratamiento de pacientes seleccionados con enfermedad coronaria, ha generado gran expectativa gracias a la seguridad y eficacia que han demostrado en comparación con los stents liberadores de medicamento, con resultados de no inferioridad y con el ofrecimiento de una serie de ventajas por las cuales ha sido considerado la «cuarta revolución». En este artículo se hace una revisión acerca de las plataformas existentes, de su mecanismo de acción, así como de sus potenciales ventajas y limitaciones.

  6. Migration of radionuclide I-131 through a clayey porous matrix

    International Nuclear Information System (INIS)

    Hamlat, M.S.

    1996-01-01

    The chemical and physical behavior of the radiotracer I-131 through a porous matrix are described. The study was evaluated using the laboratory column, which contains porous soils. The collected activities have been measured by gamma counting with a NaI(Tl) detector. The indicators were observed and analyzed by using the one dimension mass transport equation. The solution was utilized to interpret the obtaining experimental data. The experimental values of I-131 are in agreement with those calculated by the model. However, the utilization of (I-131) in the punctual hydrogeological studies is proved. (author). 5 refs., 2 figs., 2 tabs

  7. Terapia con metformina y embarazo en pacientes con síndrome de ovario poliquístico

    OpenAIRE

    Arias E.,María C.; Reid S. de O.,Iván; Acuña S.M.,Margot; Muster O.,Hugo

    2004-01-01

    Estudio prospectivo de seguimiento de 15 pacientes con síndrome de ovario poliquístico (SOP) e hiperinsulinemia que se embarazaron con el uso de metformina, y que se siguieron hasta el parto. Diez continuaron metformina durante el embarazo, hasta las 14 semanas y cinco hasta las 32 semanas. Las 5 pacientes que usaron más tiempo el medicamento no desarrollaron diabetes gestacional a diferencia de las que lo tomaron hasta las 14 semanas que presentaron diabetes gestacional en tres de diez. No e...

  8. La eficacia de la terapia asistida con animales en personas con discapacidad. Analisis de los flujos comunicativos entre la persona con trastorno del espectro del autismo y el perro de terapia

    OpenAIRE

    Barbado Sánchez, Alejandra

    2016-01-01

    [ES] A lo largo de la historia, los animales siempre han tenido un papel muy importante en la vida de las personas, tanto a la hora de proporcionar alimentos como para el transporte. También se tenía la idea de que los animales tenían poderes curativos (animismo). Hay evidencias de que ya en la antigua Grecia se daban paseos a caballo a personas que padecían enfermedades incurables como parte de la terapia para aumentar su autoestima. Así pues, desde tiempos remotos los animales han sido uti...

  9. Get the Facts About Exposure to I-131 Radiation

    Science.gov (United States)

    ... Data Conducting Clinical Trials Statistical Tools and Data Terminology Resources NCI Data Catalog Cryo-EM NCI's Role ... affected by I-131 fallout from nuclear testing. Medical signs —A lump or nodule that an individual ...

  10. Three cases of respiratory failure after I-131 radioiodine therapy

    International Nuclear Information System (INIS)

    Watanabe, Ken; Uchiyama, Masayuki; Fukuda, Kunihiko

    2016-01-01

    We report three cases of respiratory failure after I-131 radioiodine therapy. All cases involved relapsed cervical lesions, and two showed edema of the larynx. Emergency tracheostomy was performed to treat the respiratory failure in one case while the others were treated conservatively. All patients showed improvements without after-effects. Patients who undergo I-131 radioiodine therapy, especially those with cervical lesions, should be carefully monitored for this rare complication after treatment. (author)

  11. Efectividad de la terapia floral para el tratamiento de la depresión en pacientes adultos mayores con cáncer

    Directory of Open Access Journals (Sweden)

    Arely Díaz Cifuentes

    2014-08-01

    Full Text Available Se realizó un estudio experimental con el objetivo de determinar la efectividad de la terapia floral en el tratamiento de la depresión leve y moderada, en adultos mayores con cáncer, en el Hospital Provincial Docente de Oncología María Curie, de la provincia de Camagüey, Cuba; el período de estudio comprendió desde enero de 2011 hasta enero de 2012. El universo contempló los pacientes neoplásicos de la tercera edad con síntomas de depresión, remitidos a la consulta de Medicina Tradicional y Natural de la institución y la muestra quedó integrada por 100 pacientes que cumplían los criterios de inclusión y exclusión, los cuales se dividieron en dos grupos de 50 cada uno: el A con tratamiento floral y el B con tratamiento convencional. Se evaluó la persistencia de los síntomas depresivos a los tres y a los seis meses después de aplicado el tratamiento. La terapia floral fue efectiva en el 94% de los casos. Se evidenció la existencia de situaciones intensas antes de ser diagnosticados con cáncer, la más relevante fue la separación familiar, en el 70% de la muestra. Los pacientes del grupo A evolucionaron mejor que los del B. En los primeros, se redujeron notablemente los síntomas depresivos a los tres meses, situación más notable a los seis meses de tratamiento, avalando como efectiva la terapia floral empleada. No se reportaron efectos adversos

  12. Aplicación de la terapia de aceptación y compromiso a un caso de crisis de angustia con agorafobia: un estudio de caso

    OpenAIRE

    Morón Gaspar, Rafael

    2005-01-01

    Se presenta el caso de un joven con crisis de angustia con agorafobia (APA, 1994) si bien se ha conceptualizado desde un punto de vista funcional como un Trastorno Evitativo Experiencial (Luciano y Hayes, 2001). La resolución del caso se ha llevado a cabo mediante la Terapia de Aceptación y Compromiso (ACT). Se aplicó en formato individual durante 9 sesiones. Los resultados obtenidos, tanto en este estudio como en otros, indica que este abordaje terapéutico es adecuado cuando se trata de u...

  13. Aplicación de nuevas tecnologías en personas mayores con trastorno cognitivo leve-moderado desde la Terapia Ocupacional

    Directory of Open Access Journals (Sweden)

    María del Carmen Rodríguez Martínez

    2017-05-01

    Full Text Available Esta revisión bibliográfica pretende ofrecer una visión de las posibilidades que ofrecen las nuevas tecnologías a personas mayores con deterioro cognitivo leve-moderado para retardar o frenar los síntomas de deterioro cognitivo. Actualmente, las nuevas tecnologías de la información y la comunicación tienen mucho protagonismo y se han convertido en una herramienta con mucho potencial para este tipo de personas. Para ello, se han  analizado una serie de estudios sobre el uso de las nuevas tecnologías en personas mayores con trastornos cognitivos con el fin de ofrecer una visión más clara sobre los datos obtenidos hasta el día de hoy respecto a este campo de investigación en Terapia Ocupacional. Se seleccionaron un total de 204 artículos, tras un proceso de duplicación y tras pasar diferentes herramientas de calidad, quedaron un total de 7 artículos. Los resultados encontrados indican que las nuevas tecnologías contribuyen a disminuir algunos síntomas asociados a la enfermedad, como la ansiedad y la depresión, mejorando además ciertas funciones cognitivas en personas que tienen un deterioro cognitivo leve-moderado, siendo importante combinarlas con las terapias tradicionales.

  14. Síndrome de lipodistrofia en pacientes con VIH/sida que reciben terapia antirretroviral de gran actividad en Tepic, México

    Directory of Open Access Journals (Sweden)

    Rogelio Alberto Fernández Argüelles

    2012-06-01

    Full Text Available Objetivo: determinar la relación entre la manifestación del síndrome de lipodistrofia y la terapia antirretroviral de gran actividad en pacientes con VIH/sida. Métodos: se realizó un estudio descriptivo, transversal y correlacional en pacientes con VIH/sida que reciben terapia antirretroviral de gran actividad, atendidos entre marzo y diciembre de 2007 en el Centro Ambulatorio de Prevención y Atención del Sida e Infecciones de Transmisión Sexual (CAPASITS de Tepic, Nayarit, México. La definición y diagnóstico del síndrome se realizó mediante el método de The National Centre in HIV Epidemiology and Clinical Research (NCHECR de Australia. Se utilizó la prueba de chi cuadrado para evaluar la dependencia entre el síndrome y la terapia. Se evaluaron 175 pacientes (128 hombres y 47 mujeres, de 19 a 72 años de edad. Resultados: se diagnosticaron 141 pacientes (80,6 con síndrome de lipodistrofia (IC95% 74,7-86.4 %; el 82,6 % correspondió a hombres y el 74,5 % a mujeres. Según la severidad, el porcentaje fue de 17 % de grado 1, 3 % de grado 2, 10 % de grado 3 y 51 % de grado IV. Las pruebas de chi cuadrado para evaluar dependencia entre el síndrome y la terapia resultaron no significativas. Conclusiones: el síndrome de lipodistrofia severo resulta un serio problema para la apariencia de pacientes de VIH/sida que reciben o no la terapia antirretroviral y que agrega un riesgo cardiovascular importante que debe ser considerado para intentar su prevención o tratamiento. Aunque los resultados pueden presentar sesgos y limitaciones, aportan una aproximación importante para sustentar y planificar intervenciones sanitarias que disminuirían el impacto del síndrome en la salud de los pacientes con VIH/sida.

  15. Calculated activity incorporated in the therapy with I131

    International Nuclear Information System (INIS)

    Chica, L.G.; Puerta, J.A.

    1998-01-01

    By means of the product S(T→ S).A s (T e ), the absorbed dose to thyroid delivered by I 131 incorporated is calculated. Where S(T→ S) is the absorbed dose in the thyroid per nuclear transformation (tn.) of I 131 localized in the thyroid and as a potential function of the mass is expressed. A s (T e ) is the number of tn. of I 131 in the thyroid since the moment of the incorporation until the time T e (the effective middle time); to find A s (T e ) to normal as different pathological conditions, the metabolic model of the iodo proposed by the ICRP is used. Of the expressions of the doses, the incorporated activity, l o , is obtained

  16. Radiation exposure estimation from patient treated by I-131

    International Nuclear Information System (INIS)

    Lahfi, Y.; Anjak, O.

    2012-09-01

    Radioactive iodine is the main radiopharmaceutical substance in the nuclear medicine field which used in diagnosis and treatment of patients suffering from thyroid cancer; thus it can be considered as the main source of the public and patient relative exposure. In this study, 192 patients were selected randomly and their radiation dose rate was measured at different levels of the patient's body (thyroid, knee, bladder) after one, twenty four and forty eight hours from availing the prescript quantity of the I-131. The collected data may serve in estimating the worker and public exposure related to the patient treated by I-131. (authors)

  17. Uso de los sistemas de presión negativa en el tratamiento de infecciones asociadas a dispositivos: “una vieja terapia con un uso novedoso”

    OpenAIRE

    William Fernando Bautista Vargas; Diego Andrés Rodriguez Guerrero; Luis Carlos Sáenz

    2017-01-01

    Introducción: El cuidado de los pacientes con infecciones asociadas al dispositivo sin endocarditis, incluye: la extracción completa y la realización de capsulectomía para evitar la reinfección. El uso de nuevos elementos como el sistema de la presión negativa es una terapia novedosa que ha demostrado disminuir: los tiempos de recuperación, el tiempo de estancia intrahospitalaria, la necesidad de nuevas intervenciones por sangrado o lavado y el tiempo de espera para un nuevo implante. Nuestro...

  18. Terapia floral como medio de transformación psíquica y orgánica en una paciente con síndrome de Down

    Directory of Open Access Journals (Sweden)

    Mercedes Gay Muguercia

    2014-07-01

    Full Text Available Se describe el caso clínico de una paciente de 23 años de edad, con síndrome de Down, quien presentaba retraimiento, miedo, marcada tartamudez, obesidad, hipertensión arterial e hipercolesterolemia, para lo cual se le indicó terapia floral. Se le realizaron los exámenes físicos y complementarios pertinentes y fue evaluada a los 21, 45 y 90 días. Finalmente, se lograron transformaciones emocionales orgánicas y físicas, de manera que se observó un cambio significativo en su comportamiento

  19. The Relative Frequency of Persistent Hyperthyroidism After I131Therapy

    International Nuclear Information System (INIS)

    Al-EID, M.A.

    1998-01-01

    517 patients with different types of hyperthyroidism who had treated by I 131 therapy were studied. The study demonstrated that diffuse toxic goiter was the most common type of hyperthyroidism. The relative frequency of persistent hyperthyroidism in all types after the first dose of I 131 utilizing our empirical regimen in estimation of therapy doses was low (9.5%). While high frequency of persistent hyperthyroidism among diffuse toxic goiter patients (14%), probably was due to many factors discussed in this paper. Some of these factors are impossible to be estimated precisely and therefore, can not be avoided. But careful dose estimation for each case with diffuse toxic goiter may reduce the rate of retreatment by I 131 . Antithyroid medication prior to I 131 therapy might be another factor resulted in increasing of retreatment of retreatment rate diffuse toxic goiter cases. Longer time interval (more than 5 days) of ceasing antithyroid medication prior therapy is suggested to avoid the effects of these drugs. Patients with other types of hyperthyroidism were not frequently required more than one dose and the frequency of persistent hyperthyroidism was almost negligible

  20. Experimental radioimmunotherapy with I-131-antibody against a differentiation antigen

    International Nuclear Information System (INIS)

    Badger, C.C.; Krohn, K.A.; Bernstein, I.D.

    1985-01-01

    The authors have previously shown that I-131-labeled antibodies (Ab) against the Thyl.l antigen can care AKR/Cu (Thyl.2+) mice bearing the AKR/J (Thy 1l.1+) SL2 T-cell lymphoma. The authors have now extended these studies to therapy with I-131-anti-Thyl.1 of SL2 lymphoma in AKR/J mice where Ab reacts with both tumor and normal cells. A 25 μg bolus was rapidly cleared from serum by binding to spleen cells (75% with Tl/2 <60 min.) and only low concentrations of Ab(<2% ID/gm) were present in tumor after infusion. Therapy of AKR/J mice bearing established s.c. lymphoma nodules with 1500 μCi I-131-anti-Thyl.1 resulted in complete regression of the nodule in 6/6 animals although tumor eventually regrew and all animals died of metastatic lymphoma. In contrast, I-131-irrelevant Ab given to produce the same amount of whole body radiation (750 μCi) did not affect tumor growth. These studies suggest that radiolabeled-AB against differentiation antigens may be useful for therapy in spite of binding to normal cell populations

  1. Terapia asistida con perros

    OpenAIRE

    Martínez Artime, Aida.

    2010-01-01

    Descripció del recurs: 28 abril 2011. Treball presentat a la Facultat de Veterinària de la Universitat Autònoma de Barcelona. Treball presentat a l'assignatura de Deontologia i Veterinària Legal (21223)

  2. Tratamiento de necrosis plantar postsepsis neumocóccica con terapia V.A.C.® Treatment of post-pneumococcal plantar necrosis with VAC® therapy

    Directory of Open Access Journals (Sweden)

    E. Guisantes

    2011-12-01

    Full Text Available La terapia VAC® es un dispositivo que favorece la curación de las heridas mediante un sistema cerrado que aplica presión negativa sobre el lecho. Este tratamiento favorece la cicatrización porque reduce el edema y el líquido intersticial, mejora la microcirculación, disminuye el riesgo de infección y favorece la granulación del tejido. Presentamos un caso clínico de un varón de 31 años con un defecto amplio plantar tras necrosis distal por sepsis neumocóccica. Tras 20 días de terapia VAC® la granulación fue adecuada y permitió la cobertura del defecto con un injerto de piel. La terapia VAC® es una opción útil para la reconstrucción de defectos plantares amplios de forma sencilla.VAC® Therapy is a device that lets promote wound healing through a closed system that applies negative pressure on the wound bed. This treatment promotes healing by reducing edema and interstitial fluid, improving microcirculation, reducing the risk of infection and promoting tissue granulation. We report the case of a 31 year old man with a large plantar defect due to distal necrosis after pneumococcal sepsis. After 20 days of VAC® therapy, the granulation was adequate and allowed the coverage of the defect with a skin graft. VAC® therapy is a useful and simple option for reconstruction of broad plantar defects.

  3. Effective Half-life of I-131 in Patients with Differentiated Thyroid Cancer Treated by Radioactive I-131

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seok Gun [Dankook University, Cheonan (Korea, Republic of)

    2008-12-15

    Effective half life of I-131 (T{sub eff}) in patients with differentiated thyroid cancer treated by I-131 is must-know value for dose calculation and determination of release time from isolation room. There has been no report about T{sub eff} in Koreans. Thus, author tried to measure dose rate without radiation exposure to faculty members and calculated T{sub eff}. Probe of radiation survey meter was fixed at the wall of isolation room, and body of survey meter was placed outside the room. With this simple arrangement, author could measure radiation frequently without radiation exposure to faculty members in 68 patient (F=55, M=13, age=47{+-}13.7) treated by I-131 (3.7{approx}7.4 GBq) for differentiated thyroid cancer from Jan 2006 to Dec 2006. From this data, T{sub eff}, 48 hr retention rate, and the time necessary to whole body retention of I-131 become less than 1.1 GBq were calculated. Serum creatinine levels were measured before and after thyroid hormone withdrawal. T{sub eff} was 15.4{+-}4.3 hr (9.4{approx}32.5 hr). There was a loose correlation between T{sub eff} and serum creatinine concentration (r=0.45). 48hr retention was 4.9{+-}4.2% (1{approx}23%). Time necessary to whole body retention of I-131 become less than 1.1 GBq was calculated as 47.1{+-}13.2 hr for 9.25 GBq, 42.1{+-}11.9 hr for 7.4 GBq, 35.7{+-}10.0 hr for 5.55 GBq, and 26.7{+-}7.5 hr for 3.7 GBq dose of I-131. Author successfully measured radiation dose rates in isolated patients treated by high dose of I-131 without radiation exposure to the faculty members with simple arrangement of survey meter probe. Using those data, T{sub eff} and some other indices were calculated.

  4. Musicoterapia, ejercicio físico y terapia asistida con animales en ancianos con depresión. Revisión bibliográfica

    OpenAIRE

    García Díez, Isabel

    2017-01-01

    La depresión es la enfermedad psiquiátrica más frecuente en los ancianos. A pesar de ello, esta patología, que afecta negativamente a la calidad de vida, se encuentra infradiagnosticada e infratratada en este grupo poblacional. Actualmente, el principal tratamiento empleado es la farmacoterapia, sin embargo, existen otras terapias alternativas, como la musicoterapia, el ejercicio físico y la terapia asistida por animales, que pueden ser realizadas por la enfermera. Nuestro objetivo es valo...

  5. Perfil Clínico-Epidemiológico de Pacientes que inician Terapia Intensiva con Estatinas para La Prevención Secundaria de Enfermedad Vascular en España

    Directory of Open Access Journals (Sweden)

    Diego Macías Saint Gerons

    2015-01-01

    Full Text Available Las nuevas recomendaciones respecto a la utilización de estatinas potentes y/o dosis altas (terapia intensiva para el tratamiento de la enfermedad cardiovascular se han basado en la extrapolación de los resultados de los ensayos clínicos. El objetivo fue describir el perfil clínico-epidemiológico de los pacientes que inician tratamiento con estatinas para la prevención secundaria en España y estudiar qué factores determinan la utilización de estatinas en terapia intensiva. Métodos: Estudio transversal a partir de 88.751 pacientes ≥45 años con enfermedad cardiovascular que iniciaron tratamiento con estatinas (enero 2007-diciembre 2011. Los tratamientos con dosis superiores a 40 mg/día de simvastatina (o estatina equipotente se consideraron terapia intensiva. Se construyeron modelos de regresión logística multivariante con el fin de examinar la asociación de las variables relacionadas con la prescripción de terapia intensiva respecto al uso de la terapia moderada. Resultados: Se identificó a 16.857 personas adultas que iniciaron tratamiento con estatinas para la prevención secundaria. Los factores predictores para el inicio de terapia intensiva fueron el año de prescripción, sexo masculino (odds ratio ajustada: 1,70; IC95%: 1,44-2,00, edad >75 años (1,39; 1,15-1,69, historia previa de enfermedad isquémica coronaria (1,71; 1,44-2,04, accidente isquémico transitorio de cualquier localización (1,24; 0,97-1,59, tabaquismo (1,62; 1,34-1,95, hipertensión (1,41; 1,20-1,65 y tratamiento reciente con fibratos (2,32; 1,27-4,26. Conclusiones: La utilización de terapia intensiva con estatinas está determinada por el tipo de evento vascular previo y con la edad (>75 años, en los que el balance beneficio-riesgo podría ser discutible. No se encuentran diferencias estadísticamente significativas en función del c-LDL.

  6. Microwave assistance of labeling hippuric acid by I-131

    International Nuclear Information System (INIS)

    Sherlock Huang, Lin-Chiang; Wu, Kou-Hung; Ko, Pi-Wen; Hsieh, Cheng-Ying; Pao, Kuan-Chuan; Chou, Shih-Ching; Shieh, Fa-Kuen; Sureshbabu, Radhakrishnan; Hsu, Ming-Hua

    2014-01-01

    This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nevertheless sufficient to produce labeled hippuric acid with high radiochemical purity in a short time. Therefore, the novel technique overcomes the limitations of previously reported conventional methods that involve heating. - Highlights: • We report the microwave assisted radiochemical labeling of hippuric acid by I-131. • Cu(OAc) 2 can be used as catalyst to get labeled product in lower dilution condition. • Advantages of our method are lesser time scale and high radiochemical purity.

  7. Present state of the I-131-MIBG therapy

    International Nuclear Information System (INIS)

    Fischer, M.

    1986-01-01

    Treatment of malignant pheochromocytoma and neuroblastoma stage III and IV is unsatisfactory. Locally invasive tumors may be cured by radical extirpation. The role of irradiation and/or chemotherapy in malignant pheochromocytoma is disappointing, in neuroblastoma in many cases debatable. From 1981 to the present we studied more than 250 patients by MIBG scintigraphy. 5 patients with malignant pheochromocytoma, one female patient with an intra-adrenal, probably benign pheochromocytoma and 3 children with neuroblastoma stage IV were treated with I-131-MIBG

  8. Treatment of Graves' disease with I131: Case Report

    International Nuclear Information System (INIS)

    Sanchez Povis, J.E.; Sandoval Okuma, J.C.; Contreras Carreno, S.E.; Cabello Morales, E.

    2006-01-01

    Objective: To describe the response and complications in children and teenagers suffering Graves' disease who received radioactive iodine therapy. Material and Methods: The clinical records of the patients attended at Paediatric Endocrinology Unit of Hospital Nacional Cayetano Heredia who received therapy with I 131 were reviewed. Demographic characteristics, thyroid weight, radioactive iodine uptake, I 131 dose and clinical and thyroid function evolution were registered. Results: We include thirteen patients: 1 male and 12 females. The mean thyroid weight obtained was 47.56 ± 10.70 gr. Initial calculated dose was 3.92 ± 0.95 mCi, with a total dose of 4.47 ± 1.66 mCi, and mean following period of 2.76 years. Ten patients received only one dose, 2 patients received two doses and one patient received three doses; all cases remitted. Patients who received only 1 dose showed disease remission at 13.13 weeks and mean remission period of the population was 24.62 weeks. Hypothyroidism prevalence up to six months from initiating treatment was 66.66%, and up to 257 weeks 83.33%. Conclusions: We conclude that I 131 was 100% effective in the treatment of children and adolescents suffering Graves' disease in this small series. (author)

  9. Resultado de las quemaduras tratadas mediante cultivo de células epidérmicas autólogas : reglamentos e implicaciones para ensayos clínicos internacionales con Productos de Terapia Avanzada

    NARCIS (Netherlands)

    Middelkoop, E.; Gardien, K.L.M.; Brouwer, K.M.; Waaijman, T.; Uhlrich, M.M.W.; Gibbs, S.; Ulrich, M.M.W.

    2016-01-01

    Introducción. Los Productos de Terapia Avanzada (ATMPs) son considerados el siguiente paso para mejorar la evolución de las quemaduras. Sin embargo, existen serios obstáculos para su aplicabilidad con respecto al reglamento internacional vigente. Aparte de las exigencias reglamentarias para los

  10. Distribution and Bioaccumulation of I-131 Within The Water-Fish System

    International Nuclear Information System (INIS)

    Darussalam, M; Wijaya, DGO; Sutrisno

    1996-01-01

    Distribution and Bioaccumulation of I-131 Within The Water-Fish System. As one of fission products, radioiodine I-131 potentially become a pollutant either resulted froma fallout or radioactive waste. Therefore, special interest has been given to handle I-131 starting from its production implementation and its waste management. The observations in this research have been focussed on distribution and bio accumulation of I-131 within the water-fish systems. Some number of Tilapia fish were put in aquaria containing I-131 contamined water with certain radioactivity concentration. Within time interval of 0, 6, 24, 48 and 72 hours after treatment the radioactivities of water media. fish and their organs have been measured. The results show that the radioactivity percentage different water media containing different I-131 concentration tend to have similar patterns. Meanwhile, the I-131 concentrations of fish and their organs were varied with similar patterns for different I-131 content in water media

  11. Ideación suicida y respuesta a la terapia cognitiva conductual en adolescentes puertorriqueños/as con depresión mayor

    Directory of Open Access Journals (Sweden)

    Jeannette Rosselló

    2011-01-01

    Full Text Available En Puerto Rico existe una alta prevalencia de depresión e ideación suicida (IS en adolescentes. Este estudio examinó la respuesta a una terapia cognitivo-conductual para la depresión con un protocolo para el manejo del riesgo suicida incorporado. Participaron 115 adolescentes con depresión mayor. Se realizaron análisis descriptivos, pruebas t de medidas repetidas, análisis de significancia clínica e índice de cambio confiable, correlaciones y de regresión múltiple. La IS al comienzo del tratamiento no tuvo un efecto sobre el tratamiento para la depresión. Un 34.8% de los/as participantes demostraron un índice de cambio confiable de las puntuaciones del pre al post tratamiento en IS y un 89.6% evidenciaron cambio clínico significativo en post-tratamiento. El nivel de desesperanza y la IS al comienzo del tratamiento mostraron un valor predictivo hacia el nivel de IS al finalizar el tratamiento. En conclusión, la mayoría de los/as adolescentes con depresión e IS tratados con la TCC redujeron significativamente sus pensamientos suicidas.

  12. Terapia génica con citocinas contra cáncer cervicouterino Gene therapy with cytokines against cervical cancer

    Directory of Open Access Journals (Sweden)

    Víctor Hugo Bermúdez-Morales

    2005-12-01

    Full Text Available La terapia génica es una excelente alternativa para el tratamiento de muchas enfermedades. La capacidad para manipular el DNA ha permitido dirigir la terapia génica para corregir la función de un gen alterado, aumentar la expresión de un gen o activar la respuesta inmune. Así, se puede proponer el uso del DNA como un medicamento capaz de controlar, corregir o curar una enfermedad. La terapia génica contra cáncer tiene un potencial enorme, y en la última década se han obtenido resultados muy alentadores del uso del DNA para controlar diversas neoplasias en modelos animales, lo cual ha permitido su aplicación en protocolos experimentales en humanos. Esta revisión concentra una reseña de los fundamentos de la terapia génica y su aplicación en cáncer cervical, desde el punto de vista de las alteraciones de la respuesta inmune enfocadas al microambiente tumoral y el uso de las citocinas como moduladores de la respuesta inmune.Gene therapy is an excellent alternative for treatment of many diseases. Capacity to manipulate the DNA has allowed direct the gene therapy to correct the function of an altered gene, to increase the expression of a gene and to favour the activation of the immune response. This way, it can intend the use of the DNA like medication able to control, to correct or to cure many diseases. Gene therapy against cancer has an enormous potential, and actually the use of the DNA has increased to control diverse cancer in animal models, with very encouraging results that have allowed its applications in experimental protocols in human. This work concentrates a review of the foundations of the gene therapy and its application on cervical cancer, from the point of view of the alterations of the immune system focused on the tumour micro-environment, and the use of the cytokines as immunomodulators.

  13. Lipodystrophy syndrome associated with antiretroviral therapy in HIV patients: considerations for psychosocial aspects Síndrome de la lipodistrofia asociado con la terapia antiretroviral en pacientes con VIH: consideraciones para los aspectos psicosociales Sindrome da lipodistrofia associada com a terapia anti-retroviral em portadores do HIV: considerações para os aspectos psicossociais

    Directory of Open Access Journals (Sweden)

    Ana Paula Morais Fernandes

    2007-10-01

    Full Text Available Several side effects have been strongly associated with antiretroviral therapy in HIV patients. Among them, the lipodystrophy syndrome which presents alterations in body shape with central adipose hypertrophy and peripheral lipoatrophy, reported by patients as a visible marker identifying them as HIV patients. This manuscript presents an analysis of current literature regarding the psychosocial aspects of HIV patients with lipodystrophy associated with antiretroviral therapy. The results show that the alterations in body shape can be disturbing in terms of psychosocial well being, affecting quality of life and increasing the stigma associated with the disease, with consequent disturbances in social relations. This analysis provides a preliminary review of the psychosocial aspects of lipodystrophy and further studies are needed for a better understanding of this complex syndrome, which could provide new information to be used in nursing care for HIV patients affected by this problem.Varios efectos secundarios han sido fuertemente asociados con la terapia antiretroviral en pacientes con HIV. Entre ellos, el síndrome de la lipodistrofia se presenta con alteraciones en la forma del cuerpo con hipertrofia adiposa central y lipoatrofia periférica, las cuales son reportadas por pacientes como marcas visibles que los identifica como pacientes con VIH. En este manuscrito, presentamos un análisis de literatura actual con respecto a los aspectos psicosociales de pacientes con VIH presentándose con lipodistrofia asociado con la terapia antiretroviral. Los resultados demuestran que las alteraciones de la forma del cuerpo pueden ser inquietantes en lo que se refiere al bienestar psicosocial, afectando la calidad de vida y aumentando el estigma asociado con la enfermedad, con las consiguientes dificultades en las relaciones sociales. Este análisis provee un repaso preliminar de los aspectos psicosociales de la lipodistrofia; sin embargo, otros estudios

  14. Comparison of thallium-201, Tc-99m MIBI and I-131 scan in the follow-up assessment after I-131 ablative therapy in differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Kwon, Jae Sung; Lee, Sung Keun; Kim, Doe Min; Park, Sae Jong; Jang, Kyong Sun; Kim, Eun Sil; Kim, Chong Soon

    1999-01-01

    We conducted a comparative study to evaluate the diagnostic values of Tl-201, Tc-99m MIBI and I-131 scans in the follow-up assessment after ablative I-131 therapy in differentiated thyroid cancer. The study population consisted of 20 patients who underwent surgical removal of thyroid cancer and ablative radioactive iodine therapy, and followed by one or more times of I-131 retreatment (33 cases). In all patients, Tl-201, Tc-99m MIBI, diagnostic and therapeutic I-131 scans were performed and the results were analyzed retrospectively. Also serum thyroglobulin levels were measured in all patients. The final diagnosis of recurrent or metastatic thyroid cancer was determined by clinical, biochemical, radiologic and/or biopsy findings. Positive rates (PR) of Tc-99m MIBI, Tl-201, diagnostic and therapeutic I-131 scans in detecting malignant thyroid tissue lesions were 70% (19/27), 54% (15/28), 35% (17/48) and 63% (30/48), respectively. The PR in the group of 20 cases (28 lesions) who underwent concomitant Tl-201 and I-131 scans were in the order of therapeutic 131 scan 71%, Tl-201 scan 54% and diagnostic I-131 scan 36%. There was no statistically significant difference between Tl-201 and diagnostic I-131 scans (p>0.05). In the group of 20 cases (27 lesions) who underwent concomitant Tc-99m MIBI and I-131 scans, the PR were in the order of Tc-99m MIBI scan 70%, I-131 therapeutic scan 52% and I-131 diagnostic scan 33%. The PR of Tc-99m MIBI was significantly higher than that of diagnostic I-131 scan (p<0.05). Tc-99m MIBI scan is superior to diagnostic I-131 scan in detecting recurrent or metastatic thyroid cancer following ablation therapy in patients with differentiated thyroid cancer. Tl-201 scan did not showed significantly higher positive rate than diagnostic I-131 scan. Instead of diagnostic I-131 scan before the I-131 retreatment, Tc-99m MIBI scan without discontinuing thyroid hormone replacement would be a prudent and effective approach in the management of these

  15. Efectividad de la terapia floral de Bach en pacientes con alcoholismo crónico Effectiveness of Bach flower therapy in patients with chronic alcoholism

    Directory of Open Access Journals (Sweden)

    Noraima Contrera Vega

    2012-04-01

    Full Text Available Se realizó una intervención terapéutica en 15 pacientes con alcoholismo crónico, pertenecientes al Grupo Básico de Trabajo No. 3 del Policlínico Docente "Armando García Aspurú", de Santiago de Cuba, desde junio de 2008 hasta febrero de 2009, a fin de evaluar la efectividad de la terapia floral de Bach en el tratamiento de dichos pacientes, para lo cual se aplicó primero un esquema terapéutico general y luego individual. Se emplearon la media aritmética para cuantificar los datos, la desviación estándar para estimar la variabilidad y el porcentaje como medida de resumen, con un intervalo de confianza de 95 %. La favorable evolución observada en la mayoría de ellos puso de manifiesto la utilidad de esta terapia para disminuir manifestaciones psicosomáticas de ansiedad, depresión e insomnio y mejorar así la calidad de vida, tanto de los afectados como de sus familiares.A therapeutic intervention was performed in 15 patients with chronic alcoholism, belonging to the Working Basic Group No. 3 of "Armando García Aspurú" Teaching Polyclinic in Santiago de Cuba, from June 2008 to February 2009, in order to evaluate the effectiveness of Bach flower therapy in the treatment of these patients, thus applying a therapeutic regimen generally first and then individually. The arithmetic mean to quantify the data, the standard deviation to estimate the variability and the percentage as summary measure were used, with a 95% confidence interval. The favorable course observed in most of them demonstrated the usefulness of this therapy to reduce psychosomatic manifestations of anxiety, depression and insomnia and improve the life quality of both patients and their families.

  16. Vocal cord paralysis following I-131 ablation of a postthyroidectomy remnant

    International Nuclear Information System (INIS)

    Lee, T.C.; Harbert, J.C.; Dejter, S.W.; Mariner, D.R.; VanDam, J.

    1985-01-01

    Vocal cord paralysis has been reported following I-131 therapy of thyrotoxicosis and following ablation of the whole thryoid. However, this rare complication has not previously been described following I-131 ablation of a postthyroidectomy remnant. The authors report a patient who required tracheostomy for bilateral vocal cord paralysis following I-131 ablation after near-total thyroidectomy for papillary thyroid carcinoma

  17. Qualidade de vida de pacientes com câncer de mama em terapia adjuvante Calidad de vida de pacientes con cáncer de mama en terapia adyuvante Quality of life of breast cancer patients in adjuvant therapy

    Directory of Open Access Journals (Sweden)

    Adriana Cristina Nicolussi

    2011-12-01

    Full Text Available O objetivo do estudo foi avaliar a Qualidade de Vida (QV, identificar os domínios afetados em pacientes com câncer de mama em terapia adjuvante e correlacioná-los com características sócio-demográficas, clínicas e terapêuticas. Estudo transversal, realizado com 35 pacientes entre agosto de 2007 e dezembro de 2008. Utilizou-se o instrumento Quality of Life Core-30-Questionnaire (QLQ-C30. A Qualidade de Vida geral foi considerada pouco satisfatória. Os domínios afetados foram: função emocional, insônia, dor e fadiga. Nas correlações, as pacientes acima de 60 anos apresentaram pior escore na função emocional, as submetidas à cirurgia referiram mais constipação, as que realizavam radioterapia obtiveram pior escore para QV geral e as que estavam em quimioterapia há mais de seis ciclos apresentaram a função emocional afetada e dispnéia. Concluiu-se que os tratamentos adjuvantes afetaram de algum modo as pacientes, causando déficit na função emocional e relataram mais sintomas, prejudicando assim sua QV.El objetivo fue evaluar la calidad de vida (CV, identificar los dominios afectados en pacientes con cáncer de mama en terapia adyuvante y correlacionarlos con las características socio-demográficas, clínicas y terapéuticas. Estudio transversal, con 35 pacientes, realizado entre agosto de 2007 y diciembre de 2008. Fue utilizado el instrumento Quality of Life Core-30-Questionnaire (QLQ-C30. La calidad de vida fue considerada poco satisfactoria. Los dominios más afectados fueron: función emocional, insomnio, dolor, fatiga. En las correlaciones, las pacientes con más de 60 años presentaron peores promedios en la función emocional, las pacientes que fueron sometidas a la cirugía refirieron más estreñimiento, las que recibían radioterapia presentaron peores promedios en CV general y las que habían recibido más de seis ciclos de quimioterapia presentaron la función emocional afectada y la disnea. Se concluyó que los

  18. Dosimetry prior to I-131-therapy of benign thyroid disease

    International Nuclear Information System (INIS)

    Haenscheid, Heribert; Lassmann, Michael; Reiners, Christoph

    2011-01-01

    The activity to be administered in I-131 therapy of benign thyroid disease is determined by the radiation absorbed dose necessary to cure the disease, the target mass, and the residence time of the I-131 in the target volume. Data from 73 patients with complete sets of uptake measurements 2, 6, 24, 48, and 96 (n = 53) or 120 (n = 20) hours after oral administration of 1 MBq I-131 were used to deduce residence times from subsets of 3, 2, or only 1 measurement for each individual. The values were compared to those obtained with the reference method, i.e. a fit of an uptake function based on a 2-compartment model to all 5 measurements, to quantify the errors introduced by the less demanding assessments. Deviations are less than 10% if the 2- compartment uptake function is fitted to only 3 values measured after 6, 24, and 96-120 h. Use of 2, 24, and 96-120 h data results in errors > 20% in individual patients. The effective half-lives as determined from 2 measurements after 24 and 96-120 h correlate well with those deduced from the reference method with larger deviations in individuals with slow iodine kinetics and late maximal uptake. Residence times determined from the 24 h uptake, assuming linear increase during the first day, and the effective half-life limited to maximum 8 days underestimate the actual values systematically in patients with long and short half-lives. These errors can be eliminated by a modification of the calculation method resulting in deviations less than 14% in all but one individual for this procedure. The accuracy of methods based on only one retention value increases with the time of measurement after the administration of I-131. While systematic errors up to a factor of two occur if the 24 h uptake is used for the estimate, deviations are less than 18% for measurements after 120 h. The results suggest that only one late uptake assessment warrants residence time estimates with an acceptable error. Given the high inherent uncertainties in the

  19. Resultados del seguimiento de pacientes con Trastorno Obsesivo Compulsivo tratados con dos variantes de Terapia Cognitiva Follow-Up of patients with Obsessive Compulsive Disorder treated with two variants of Cognitive Therapy

    Directory of Open Access Journals (Sweden)

    Ricardo Rodríguez Biglieri

    2007-12-01

    Full Text Available El artículo presenta los resultados del seguimiento a 6 meses realizado a pacientes con trastorno obsesivo compulsivo en el marco del proyecto UBACyT P079. Para el estudio se utilizó un diseño de caso único (A-B con replicación directa entre sujetos. Ocho pacientes fueron asignados aleatoriamente a una de las dos condiciones de tratamiento ofrecidas: 1 Terapia centrada en exposición y Prevención de respuesta; 2 Terapia Metacognitiva. Dos de los pacientes en la primera condición abandonaron el tratamiento tras la tercera sesión. Los cuatro de la segunda condición finalizaron el protocolo establecido. Los resultados para ambos tipos de terapia muestran una mejoría significativa en la sintomatología obsesiva y depresiva tras su aplicación, resultados que se han mantenido estables en las evaluaciones de seguimiento, sugiriendo la utilidad clínica de ambas terapias. Se discuten las implicaciones teóricas y prácticas de los resultados y se sugieren nuevas líneas de investigación.The article presents the follow-up at six months of patients with obsessive compulsive disorder treated in the context of UBACyT project P079. A single case design (A-B between subjects with direct replication was used. Eight patients were randomly assigned to one of two different treatment conditions: 1 Exposure and Response Prevention Therapy (Ex/PR; 2 Metacognitive Therapy (MT. Two patients in the Ex/PR condition dropped out after the third session. There was no dropout of patients under MT condition. Outcomes from both kinds of treatment show a significant improvement in obsessive and depressive sympthomatology after the interventions. These findings were sustained at the follow- up evaluations, suggesting that both treatments may be of clinical utility. Theoretical and practical implications are discussed, and further lines of investigation are outlined.

  20. Radioiodine (I-131) therapy in thyroid cancer differentiated type (abstract)

    International Nuclear Information System (INIS)

    Khan, M.S.

    1999-01-01

    Carcinoma thyroid is not an uncommon malignancy in Pakistan because of its location in iodine deficient terrain. Painless palpable (solitary) thyroid nodule is the common presentation in majority (>90%) of the patients and > 25% cold nodules in females turned malignant on biopsy whereas in males >75% of cold nodules turned malignant on historical examination. The disease is more common in females as compared to males (3:1) and in females pure papillary carcinoma is more common whereas in males mostly follicular or mixed tumors are seen. Radical surgery (thyroidectomy) is not a routine surgical treatment in our country. In teaching hospitals the routine surgical procedure is lobectomy and Isthmectomy, whereas in DHQ Hospitals less surgical procedures, e.g. tumorectomy or partial labectomy etc. are done. Therefore, in view of limited/partial surgical ablation, I-131 ablation is mandatory for better and longer survival. We have treated 118 patients of thyroid carcinoma (Differential type) at our centre (AEMC) with therapeutic dose of Radioactive iodine (I-131) during the last 13 years with encouraging results (Disease free survival). (author)

  1. Calibration of filters for detection of airborne I-131 in the environment of nuclear power plant; Kalibracija filtrov za detekcijo I-131 v zraku okolja jedrske elektrarne

    Energy Technology Data Exchange (ETDEWEB)

    Zupan, M; Miklavzic, U; Pucelj, B [Institut Jozef Stefan, Ljubljana (Yugoslavia)

    1982-07-01

    A simple and clean method for efficiency calibration of filters for collection of airborne I and corresponding Ge(Li) spectrometer is described. As the calibrated source of gaseous I-131 the radiopharmaceutical water solution of NaI is used. As calibration example the absolute activity distribution of I-131 measured in a charcoal filter is shown. (author)

  2. Características clínicas de pacientes tratados con terapia electroconvulsiva en un hospital público de Perú

    Directory of Open Access Journals (Sweden)

    Carla Cortez-Vergara

    2016-01-01

    Full Text Available Con el objetivo de describir el perfil de uso de la terapia electroconvulsiva (TEC en pacientes hospitalizados en el Instituto Nacional de Salud Mental "Honorio Delgado - Hideyo Noguchi" de Lima, Perú, se revisaron las historias clínicas de pacientes que recibieron TEC entre los años 2001 y 2011. Se aplicaron 419 cursos de TEC a 372 pacientes, con un total de 5439 aplicaciones; la esquizofrenia paranoide fue el diagnóstico más frecuente (70,7%, y la indicación más usual fue la resistencia al tratamiento (80,7%; asimismo, la respuesta clínica a la TEC fue buena en 70,1% de casos, mientras que los efectos secundarios, en general, fueron pasajeros y leves. El uso de TEC disminuyó a lo largo del periodo estudiado, pero fue muy tolerable y segura, especialmente en su versión modificada, y mostró una alta respuesta que la mantiene como un tratamiento psiquiátrico de primera línea.

  3. I-131 rose bengal excretion test is not dead

    International Nuclear Information System (INIS)

    Antico, V.F.; Denhartog, P.; Ash, J.M.; Gilday, D.L.; Houle, S.

    1985-01-01

    One hundred and thirty I-131 Rose Bengal Excretion Studies (RBI) were performed on 84 patients over nine years. In 90% (56/60) of cases with biliary atresia, the 72-hour RBI was less than or equal to 7%. In only 12.5% (3/24) of cases with neonatal hepatitis was the 72-hour RBI less than or equal to 7%. The accuracy of the test was 91% with a specificity of 88%. Thirty patients later were studied following a Kasai procedure. The RBI test reliably predicted the patency of the anastomosis. The authors conclude that the 72-hour RBI is a reliable test in the diagnosis of biliary atresia and in the documentation of biliary patency following surgery, provided adequate care is taken in stool collection and measurement

  4. Reducing radiation exposure during oral I-131 therapy administration

    International Nuclear Information System (INIS)

    Trujillo, J.; Krinsky, S.; Wilson, B.; Teague, E.

    1982-01-01

    A new, closed-system method to reduce air-, direct-, and incidental-contamination during therapeutic administration of oral I-131 was experimentally evaluated on twelve patients. We studied a standard control population using the routine practice of drinking the solution through a straw and compared results with our new technique. Various measurements were performed throughout all phases of dose administration to assess the relative difference of the two approaches. Using the closed system method before and during iodine administration revealed between 100 and 1000 times less activity per millimeter of air sample; whereas, the direct radiation exposure values were higher for the control population. Both the experimental and control methods had similar levels of incidental contamination

  5. Terapia combinada con magneto, láser y ejercicios en la tendinitis de hombro: Servicio de Rehabilitación Integral José Jacinto Milanés. Junio 2007-junio 2008

    OpenAIRE

    Solís de la Paz, Dayma; Peñate Brito, Jayne Bárbara

    2011-01-01

    La magnetoterapia, aunque ha sido utilizada para diversas afecciones ortopédicas, no se ha empleado en la tendinitis asociada al láser y a los ejercicios terapéuticos, por lo que se realizó un estudio explicativo, experimental, tipo ensayo clínico terapéutico, para comprobar la eficacia de esta terapia en pacientes con tendinitis en el Servicio de Rehabilitación Integral José Jacinto Milanés. Se conformaron dos grupos con 42 pacientes, uno experimental con aplicación local de campos magnético...

  6. Eficacia y seguridad de la terapia tópica con capsaicina 0,075% versus mentol 1%, en el tratamiento del prurito de la foliculitis eosinofílica asociada al virus de la inmunodeficiencia adquirida

    Directory of Open Access Journals (Sweden)

    Carlos Galarza

    2007-09-01

    Full Text Available Objetivo: Determinar la eficacia y seguridad de la terapia tópica con capsaicina 0,075% versus mentol 1% en el tratamiento del prurito de la foliculitis eosinofílica asociada al virus de la inmunodeficiencia adquirida (VIH. Diseño: Estudio clínico aleatorizado y doble ciego. Lugar: Servicios de Enfermedades Infecciosas y Tropicales (SEIT y Dermatología, Hospital Nacional Dos de Mayo, Lima, Perú. Participantes: Pacientes con foliculitis eosinofílica asociada al VIH. Intervenciones: La muestra estuvo constituida por 40 pacientes con foliculitis eosinofílica asociada al VIH, quienes fueron distribuidos mediante muestreo aleatorio sistemático en dos grupos: el grupo 1 conformado por 20 pacientes que recibieron la terapia 1; y el grupo 2, conformado por 20 pacientes que recibieron la terapia 2. Los pacientes recibieron tratamiento con capsaicina al 0,075% y mentol 1%; la aplicación se realizó en el área afectada, cada 6 horas, durante 45 días. Se implementó un sistema de visitas (domiciliarias u hospitalarias, se evaluó la eficacia en la reducción del prurito (escala de Likert y se registró los eventos. Principales medidas de resultados: Respuesta clínica a la administración de capsaicina y mentol. Resultados: La respuesta fue buena en 90% de los pacientes que recibieron capsaicina 0,075%, en comparación con 40% en el grupo que recibió mentol al 1% (p = 0,001, con OR = 0,074 (IC 95 %: 0,013 - 0,411. La eficacia de las terapias tópicas fue modificada por el recuento de linfocitos CD4 (p 0,05. Conclusiones: La terapia tópica con capsaicina es eficaz y segura en el tratamiento del prurito, en la foliculitis eosinofílica asociada al VIH.

  7. Radiodine treatment of hyperthyroidism with a simplified dosimetric approach. Clinical results; Terapia radiometabolica dell'ipertiroidismo con approccio dosimetrico semplificato. Risultati clinici

    Energy Technology Data Exchange (ETDEWEB)

    Giovanella, L.; De Palma, D.; Ceriani, L.; Garancini, S. [Azienda Ospedaliera Universitaria, Ospedale di Circolo e Fondazione Macchi, Dipt. di Diagnostica per Immagini e Radioterapia, Unita' Operativa di Medicina Nucleare, Varese (Italy); Vanoli, P.; Tordiglione, M. [Azienda Ospedaliera Universitaria, Ospedale di Circolo e Fondazione Macchi, Unita' Operativa di Radioterapia, Varese (Italy); Tarolo, G. L. [Milan Univ., Milan (Italy). Cattedra di Medicina Nucleare, Ist. di Scienze Radiologiche

    2000-12-01

    euthyroid and 12 of 146% (8%) patients hyperthyroid. Two patients were immediately submitted to a new radioiodine administration. One year posttreatment 142 of 146 (97%) patients were euthyroid while only 4 of 146 (3%) patients showed TSH levels above the normal range. Only 2 of them required thyroxine treatment. The simplified dosimetric method illustrated in this paper is very effective in clinical practice because it permits to avoid resorting to sophisticated but also imprecise quantitative methods. Hypothyroidism should not be considered as a major collateral effect of radioiodine treatment, particularly in Graves' disease. In fact, the pathogenesis of the disease requires an ablative treatment with both surgery and radioiodine treatment and the control of hyperthyroidism and the prevention of relapse are the major clinical targets. Vice versa, hypothyroidism was very uncommon in uni- and multinodular toxic goiter when the dosimetric approach was applied. [Italian] In questo documento viene valutata l'efficacia clinica di un metodo dosimetrico semplificato per la determinazione dell'attivita' terapeutica di iodio-131 da somministrare per il trattamento con intento ablativo di pazienti ipertiroidei affetti da morbo di Graves-Basedow e da gozzo uni o multinodulare tossico. Sono stati arruolati 189 pazienti ipertiroidei sottoposti a ecografia e scintigrafia tiroidea con diagnosi di morbo di Graves-Basedow (43 pazienti), gozzo uninodulare tossico (57 pazienti) e multinodulare tossico (89 pazienti). In 28 pazienti sono stati riscontrati noduli tiroidei freddi di cui e' stata effettuata la citoagoaspirazione con esclusione di caratteri citologici di malignita' in tutti i casi. La terapia medica con farmaci tireostatici e' stata sospesa 5 giorni prima del trattamento radiometabolico e, se necessario, ripresa 15 giorni dopo. Tutti i pazienti sono stati sottoposti a studio della iodocaptazione e l'attivita' terapeutica e' stata

  8. Terapia transfusional en pacientes pediátricos con drepanocitosis Transfusional therapy in pediatric patients with sickle cell disease

    Directory of Open Access Journals (Sweden)

    Lázaro Cortina Rosales

    2003-12-01

    Full Text Available Se estudiaron 158 niños con drepanocitosis, 114 con anemia drepanocítica (AD, 30 con hemoglobinopatía SC (HSC y 14 con Sb talasemia (Sb Tal. Del total, 134 fueron transfundidos, de estos 108 (94,7 % con AD, 14 con HSC (46,6 % y 12 con Sb Tal (85,6 %. Se agruparon por edades en: menores de 6 años, entre 6 y 12 años y de 13 a 18 años. La transfusión se empleó con mayor frecuencia en los menores de 6 años y sus causas fundamentales fueron: la crisis de secuestro esplénico (CSE, el síndrome torácico agudo (STA y las infecciones; estas causas variaron con la edad. Se realizó exanguinotransfusión en la crisis hepática, en la crisis vaso-oclusiva del sistema nervioso central (CVO del SNC y en el STA. El régimen de hipertransfusión se reservó para las CVO del SNC y las CSE. Las complicaciones detectadas fueron: la reacción febril no hemolítica, la aloinmunización eritrocitaria, la reacción hemolítica y las hepatitis B y C158 children with sickle cell disease, 114 with sickle cell anemia (SCA, 30 with SC haemoglobinopathy (SCH and 14 with Sb thalasemia (Sb Tal., were estudied. Of the total, 134 were transfused, 108 of them (94.7 % with SCA, 14 with SC haemoglobinopathy (SCH (46.6 % and 14 with Sb thalasemia (Sb Tal (85.6 %. They were grouped by age as follows: under 6, betweeen 6 and 12 and from 13 to 18. The transfusion was used more frequently among those under 6 and the main causes were splenic sequestration crisis (SSC, acute thoracic syndrome (ATS and infections. These causes varied according to age. Exanguinotransfusion was performed in the hepatic crisis, in the vasoocclusive crisis of the central nervous system (VOC-CNS and in the ATS. The regimen of hypertransfusion was reserved for the VOC-CNS and SSC. The complications detected were: nonhaemolytic febrile reaction, erythrocytary alloimmunization, haemolytic reaction and hepatitis B and C

  9. Terapia y educaci??n asistida con animales, como recurso innovador en el Centro Penitenciario de Albolote (Granada)

    OpenAIRE

    L??pez Fern??ndez, Esther

    2014-01-01

    La constituci??n espa??ola, en su art??culo 25.2 establece que ???las penas privativas de libertad y las medidas de seguridad estar??n orientadas hacia la reeducaci??n y la reinserci??n social???. Sin embargo, actualmente el sistema penitenciario est?? m??s orientado al cumplimiento de la pena, el castigo, y por ello surge la necesidad de trabajar de forma innovadora con los internos utilizando para ello t??cnicas dirigidas a potenciar su reeducaci??n y reinserci??n. Con tal fin surge este pr...

  10. Efecto de la terapia con ondas electromagnéticas capacitadas monopolares en el tratamiento del dolor en fibromialgia

    OpenAIRE

    Ibáñez-Vera, Alfonso Javier

    2016-01-01

    La fibromialgia es uno de los mayores problemas sanitarios de nuestro país y del mundo desarrollado con una prevalencia del 2,1%. El American College of Reumathology la define como estado doloroso generalizado en mínimo 11 de 18 puntos preestablecidos, sensibles a una presión de 4 kg/cm2 y con al menos 3 meses de evolución. La definición actual de la Organización Mundial de la Salud incluye presencia de otros síntomas como cefalea, colon irritable, menstruación dolorosa, irritabilidad, sensib...

  11. Investigations on the retention of I-131 by an iodine filter of a pressurized water reactor

    International Nuclear Information System (INIS)

    Deuber, H.; Gerlach, K.

    1984-01-01

    The retention of I-131 by an equipment room exhaust filter of a German pressurized water reactor was determined by various methods to particularly obtain reliable results. Moreover, investigations were performed to clarify the reason for aging of the carbon contained in the iodine filter mentioned. The actual retention of the organic I-131, corresponding to a value of 99.9%, was limited by I-131 in the form of penetrating iodine compounds. It was lower than the retention of CH 3 I-131 under layout conditions by more than one order of magnitude. The aging was essentially caused by the adsorption of low-volatile organic compounds. (orig.) [de

  12. Terapia celular en la necrosis aséptica de la cabeza del fémur en pacientes con drepanocitosis

    Directory of Open Access Journals (Sweden)

    Aymara Maria Baganet-Cobas

    2016-09-01

    Full Text Available Introducción: La necrosis aséptica de la cabeza femoral (NACF es una causa importante de morbilidad en pacientes jóvenes con drepanocitosis. En su tratamiento ningún método es completamente satisfactorio. Investigaciones recientes sugieren que la terapia celular puede contribuir a la reparación de tejidos como el óseo resultando útiles en el proceso de osteogénesis y angiogénesis. Objetivo: evaluar la utilidad del implante de concentrado de células mononucleares autólogas de médula ósea (CMN-MO en el tratamiento de la NACF en pacientes con drepanocitosis. Método: se incluyeron 18 pacientes, con una edad promedio de 32,8 años (rango entre 21 y 46 años, con un seguimiento mínimo de dos años. A todos se les realizó descompresión de la cabeza femoral por perforación e implante de CMN-MO. A estas células se les cuantificó por citometría de flujo expresión de moléculas CD34, CD45, CD117, HLADR, CD29 y CD14. Resultados: el promedio de viabilidad del concentrado implantado fue del 97%. Fenotípicamente las CMN-MO mostraron un patrón de expresión asociado a poblaciones de células madre adherentes del estroma medular CD34-/CD45-/DR-/CD29+/CD14-/CD117-. Los mejores resultados clínicos y radiográficos se observaron en pacientes en estadios iniciales (I o II de la enfermedad. En 12 caderas (72,9 % tratadas, los pacientes no refirieron ningún dolor a los dos años posteriores al tratamiento. Se obtuvieron buenos resultados radiológicos en siete pacientes (41,2 %. Tres pacientes (17,6 % requirieron el remplazo total de cadera. Conclusiones:el implante de CMN-MO para los primeros estadios de la NACF, es un tratamiento útil en los pacientes con drepanocitosis. El método empleado es relativamente simple y poco costoso.

  13. Radioiodine (I-131) therapy and the influence of antithyroid medication

    International Nuclear Information System (INIS)

    Duldulao, M.

    2007-01-01

    Full text: Radioiodine therapy began to play a major role in the management of hyperthyroidism as early as 1941. It later evolved to become what it is today, the treatment of choice for majority of patients who are suffering from Graves' disease and toxic nodular goiter. It is generally considered safe, inexpensive, effective, and devoid of major side effects. Despite the extensive experience with radioactive therapy, the adjunctive role of antithyroid medication remains controversial. Some authors claim that it has a positive influence on the outcome of radioiodine therapy while others insist otherwise. The reasons behind the adjunctive use of antithyroid medication include a more rapid attainment of euthyroid state and a decrease in the rise of developing thyroid crisis. However, a higher treatment failure rate is observed compared to radioiodine alone. This is due to the reputed radioprotective effect of the antithyroid medication. As a result, higher doses of I-131 are needed in order to obtain the desired effect but, unfortunately, that would also increase the radiation exposure to the rest of the body. The majority of clinicians would require discontinuation of the medication a few days before therapy to overcome these undesirable effects but the question is, is this safe? The issue of when antithyroid medication is warranted is a big question to the clinician. For optimal use of radioiodine therapy, appropriate selection criteria and good clinical judgment concerning pretreatment with antithyroid medication are required. Otherwise, we may put some patients into unnecessary increased risk and added cost. (author)

  14. Terapia biológica en cáncer: nuevos tiempos con una visión optimista

    Directory of Open Access Journals (Sweden)

    Januario E Castro

    2008-07-01

    Full Text Available A medida que las expectativas de vida aumentan también lapoblación de adultos mayores se incrementa, y con ello, elnúmero de pacientes que sufren enfermedades crónicasincluyendo cáncer. Esto ha generado que en muchos paísesindustrializados la incidencia de tumores malignos y lamortalidad asociada a cáncer haya ido aumentandoprogresivamente, siguiendo en orden de frecuencia a lasenfermedades cardiovasculares.

  15. Terapia combinada con Trastuzumab en el tratamiento del Cáncer de mama: eficacia y efectos adversos

    OpenAIRE

    Hernández Martín, María Sol

    2015-01-01

    Introducción: El cáncer de mama es el más frecuente entre la población femenina. Entre un 25-30% de los cánceres de mama son HER2-positivo. Este tipo de cáncer, se ha relacionado con una mayor agresividad clínica e histológica, mayor riesgo de recurrencia y muerte asociada al cáncer de mama. Trastuzumab, es un anticuerpo monoclonal humanizado contra este receptor. Actualmente se dispone de cuatro agentes anti-HER2 autorizados: Trastuzumab, Pertuzumab, Lapatinib y Trastuzumab...

  16. Terapias físicas aplicadas a jóvenes y adultos con parálisis cerebral

    OpenAIRE

    Valverde González, Sara

    2015-01-01

    RESUMEN: Objetivo: El objetivo de esta revisión fue estudiar qué intervenciones recientes se están llevando a cabo dentro del campo de la fisioterapia en personas con PC jóvenes y adultas ante las alteraciones de la marcha. Como objetivo secundario se quiso reflexionar sobre aspectos serán de interés teniendo en cuenta la CIF para futuros tratamientos orientados a mejorar la marcha de estas personas. Fuentes de datos y selección de los estudios: La estrategia de búsqueda se realizó en cinco b...

  17. Terapia fotodinámica in vitro con Hipericina en hongos causantes de micosis cutáneas

    OpenAIRE

    Paz Cristóbal, Manuel Pablo de la; Pardo Jimeno, Julián; Gilaberte Calzada, Yolanda; Rezusta López, Antonio

    2013-01-01

    Las infecciones cutáneas o micosis son muy frecuentes, especialmente las causadas por bacterias y hongos. Dentro de las del segundo tipo, denominadas micosis, se encuentran las producidas por hongos dermatofitos o las causadas por levaduras, especialmente por Candida spp. (15). Un uso abusivo de las sustancias antibióticas clásicas, junto con la inapropiada prescripción médica promueven la generación de resistencias de estos microorganismos frente a los agentes antifúngicos. Además, en los úl...

  18. Post-laryngectomy localization of I-131 at tracheostomy site on a total body scan

    International Nuclear Information System (INIS)

    Kirk, G.A.; Schulz, E.E.

    1984-01-01

    A post-thyroidectomy, post-I-131-therapy patient had a laryngectomy and neck dissection for recurrent papillary thyroid carcinoma. A subsequent I-131 total body scan revealed persistent anterior neck activity, which disappeared upon removal of the tracheostomy tube and dressings

  19. Experience in treatment of hyperthyroidism with I-131 diagnosis, patient preparation and therapeutic procedure

    International Nuclear Information System (INIS)

    Zhongyun, Pan

    2003-01-01

    Treatment of hyperthyroidism with I-131 diagnosis is being performed after clinical diagnosis of thyrotoxicosis based on clinical manifestations of hypermetabolic state, serumT3 and T4 determination; medical preparation of patients and therapeutic procedure is obtained for better efficacy, relieve symptoms and prevent aggravation of thyrotoxicosis after I-131 treatment

  20. I131-meta-iodobenzylguanidine in the diagnosis and treatment of neural crest tumours

    International Nuclear Information System (INIS)

    Hoefnagel, C.A.; Hartog Jager, F.C.A. den; Taal, B.G.; Engelsman, E.; Kraker, J. de; Voute, P.A.

    1988-01-01

    Iodine-131-meta-iodobenzylguanidine (I-131-MIBG) was used for scintigraphic detection and therapy of neural crest tumours. The methodology of both techniques is described. Based upon experience with I-131-MIBG-scintigraphy in 170 patients with neural crest tumours, of whom 46 received multiple therapeutic doses of I-131-MIBG, and upon the cumulative reports in the literature, the role of I-131-MIBG in diagnosis and treatment of each of these diseases is indicated. I-131-MIBG-scintigraphy is one of the most sensitive and specific techniques for the diagnosis, staging and follow-up of phaeochromocytoma and neuroblastoma and I-131-MIBG-therapy may induce remission in a number of these patients. In carcinoid and medullary thyroid carcinoma the diagnostic sensitivity is less; however, once the diagnosis has been made, it is useful to establish that the tumour concentrates I-131-MIBG, to see if the patients at some point in time may be amenable to I-131-MIBG-therapy

  1. Bioaccumulation factor for I-131 in aquatic biota II fish - tilapia (Tilapia Mossambica)

    International Nuclear Information System (INIS)

    Garcia, G.F.; Casyao, J.M.; Bautista, E.Rb.

    1982-01-01

    The study was undertaken to provide local values for an essential parameter in the estimation of the dose contribution of I-131 through ingestion of fresh water fish. The result showed that the tilapia used in the experiment did not vary significantly in weight and no definite conclusion can be derived as to the effect of body size to bioaccumulation of I-131. (ELC)

  2. Aplicación de la terapia floral de Bach en niños con retardo del desarrollo psíquico

    Directory of Open Access Journals (Sweden)

    María Elena Francia Reyes

    2003-08-01

    Full Text Available Se realizó un trabajo investigativo, prospectivo, transversal, con 100 alumnos de la Escuela Especial de Retardo del Desarrollo Psíquico "Turcios Lima", situada en el consejo popular de Cayo Hueso en el municipio Centro Habana, con el objetivo de evaluar los resultados de la aplicación de la terapia floral de Bach en el aprendizaje de estos niños diagnosticados como retardados. A principios del siglo xx el doctor Edward Bach (1886-1936, médico de origen galés, desarrollo un original y eficaz sistema de curación. Él sostuvo que la enfermedad es producto del desequilibrio entre la mente y el cuerpo, que altera el campo energético del ser vivo. El organismo se enferma ante el padecer psicológico y el desorden emocional, y expresó: "La enfermedad no es un mal a suprimir sino un beneficio a comprender." Se seleccionaron de forma aleatoria a 100 niños de dicha escuela, constituyéndose un grupo estudio y otro control. Se revisaron sus expedientes y se realizó historia clínica floral. Se realizaron entrevistas a padres y maestros para confrontar resultados. Se aplicaron remedios florales y se arribaron a conclusiones como que la aplicación de estos remedios facilita el tránsito de escuela especial a enseñanza general.At the beginning of the 20th century, a Welsh doctor named Edward Bach(1886-1936, developed an original and efficient healing system. He affirmed that the disease was the result of imbalance of the mind and the body that distorted the energy field of the live being. The body got sick due to psychological and emotional disorders, so he said "Disease is not an evil to be eliminated but a benefit to be understood." A prospective cross-sectional study of 100 students was conducted in "Turcios Lima" Special School for Psychical Development Retardation located in Cayo Hueso neighborhood, Centro Habana municipality. The objective was to evaluate the results of the application of Bach´s flower therapy in the learning process of

  3. Long-term follow-up study of I-131 therapy for Graves' disease

    International Nuclear Information System (INIS)

    Kusakabe, Kiyoko; Nakano, Keiko; Maki, Masako

    1990-01-01

    We have studied the follow-up of thyroid function in the patients with late-onset hypothyroidism and euthyroidism after I-131 therapy of hyperthyroidism. Thirty three patients who did not need the thyroid treatment until ten years after I-131 therapy were classified as euthyroid group. And eleven patients who needed the thyroid supplement of thyroid hormone for late-onset hypothyroidism were classified as hypothyroid group. Patients in both groups who required only a single dose of I-131 for successful treatment of hyperthyroidism had similar age, gland size, 24 hour I-131 uptake, pretreatment serum T 3 uptake level and T 4 concentration, and I-131 treatment dose. Subclinical hypothyroidism occurred in 28.6% of euthyroid group and 66.7% of hypothyroid group four months after I-131 therapy. The levels of T 3 were recovered to higher than normal range at 6 months in euthyroid group, while the levels of T 3 were kept within the normal range in the seventy percent of hypothyroid group. Patients who were still lower in the level of T 3 uptake than normal range at 6 months had a higher incidence of late-onset hypothyroidism. Our observation showed no significant difference in the course of follow-up studies after I-131 therapy between the patients with late-onset hypothyroidism and euthyroidism. (author)

  4. Clinical comparison of I-131 orthoiodohippurate and the kit formulation of Tc-99m mercaptoacetyltriglycine

    International Nuclear Information System (INIS)

    Taylor, A. Jr.; Ziffer, J.A.; Steves, A.; Eshima, D.; Delaney, V.B.; Welchel, J.D.

    1989-01-01

    Previous studies in animals and humans have shown that technetium-99m mercaptoacetyltriglycine (MAG3) purified by high-performance liquid chromatography is a renal tubular agent with characteristics similar to those of iodine-131 orthoiodohippurate (OIH). A kit formulation for Tc-99m MAG3 has been developed and compared with I-131 OIH in 17 patients with suspected renal dysfunction and three potential kidney donors. There were no adverse reactions. Tc-99m MAG3 images were of good quality and consistently better than I-131 OIH images. There was no significant difference in the relative renal uptake of Tc-99m MAG3 and I-131 OIH. The 30-minute urinary excretion of Tc-99m MAG3 was 36.4%, versus 40.4% for I-131 OIH. The average plasma clearance of Tc-99m MAG3 (138 mL/min +/- 117) was less than that of I-131 OIH (272 mL/min +/- 205) (P less than .001); however, there was good correlation between the Tc-99m MAG3 and I-131 OIH clearances (r = .87). The volume of distribution of Tc-99m MAG3 (5.96 L +/- 1.94) was less than that of I-131 OIH (9.41 L +/- 3.73) (P less than .001). These characteristics and the advantages of a simple kit formulation should lead to widespread clinical use

  5. The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131]iodobenzylguanidine (I-131 MIBG) in man: evaluation by scintigraphy

    International Nuclear Information System (INIS)

    Nakajo, M.; Shapiro, B.; Copp, J.; Kalff, V.; Gross, M.D.; Sisson, J.C.; Beierwaltes, W.H.

    1983-01-01

    The scintigraphic distribution of m-[ 131 I]iodobenzylguanidine (I- 131 MIBG), an adrenal medullary imaging agent, was studied to determine the patterns of uptake of this agent in man. The normal distribution of I- 131 MIBG includes clear portrayal of the salivary glands, liver, spleen, and urinary bladder. The heart, middle and lower lung zones, and colon were less frequently or less clearly seen. The upper lung zones and kidneys were seldom visualized. The thyroid appeared only in cases of inadequate thyroidal blockade. The ''normal'' adrenal glands were seldom seen and faintly imaged in 2% at 24 hr after injection and in 16% at 48 hr, in patients shown not to have pheochromocytomas, whereas intra-adrenal, extraadrenal, and malignant pheochromocytomas usually appeared as intense focal areas of I- 131 MIBG uptake at 24 through 72 hr

  6. Normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131]iodobenzylguanidine (I-131 MIBG) in man; evaluation by scintigraphy

    International Nuclear Information System (INIS)

    Nakajo, M.; Shapiro, B.; Copp, J.; Kalff, V.; Gross, M.D.; Sisson, J.C.; Beierwaltes, W.H.

    1983-01-01

    The scintigraphic distribution of m-[ 131 I]iodobenzylguanidine (I-131 MIBG), an adrenal medullary imaging agent, was studied to determine the patterns of uptake of this agent in man. The normal distribution of I-131 MIBG includes clear portrayal of the salivary glands, liver, spleen, and urinary bladder. The heart, middle and lower lung zones, and colon were less frequently or less clearly seen. The upper lung zones and kidneys were seldom visualized. The thyroid appeared only in cases of inadequate thyroidal blockade. The normal adrenal glands were seldom seen and faintly imaged in 2% at 24 h after injection and in 16% at 48 h, in patients shown not to have pheochromocytomas, whereas intra-adrenal, extra-adrenal, and malignant pheochromocytomas usually appeared as intense focal areas of I-131 MIBG uptake at 24 through 72 h

  7. Terapia Génica

    Directory of Open Access Journals (Sweden)

    Ignacio Zarante

    2001-08-01

    Full Text Available

    Definición
    La terapia génica es el proceso por el cual se inserta material genético en una célula, con el fin de hacer que ésta produzca una proteína normal. Las utilidades van desde curar enfermedades unigénicas hasta modificar el equilibrio del sistema inmune, permitiendo la modulación de la respuesta contra cualquier antígeno. En esencia es cambiar la secuencia del genotipo de un organismo para que tenga implicaciones fenotípicas.

    Historia
    Desde el descubrimiento de las enzimas de restricción en el año de 1970 por Arber y Hamilton se sentaron las bases para transferir genes entre diferentes células u organismos, inclusive pertenecientes a diferentes especies. En 1978 se realizó la primera hormona recombinante insertando el gen de la insulina en una bacteria E. coli. De allí en adelante se afianzaron los conocimientos necesarios para transferir genes a células humanas con el fin de alterar el fenotipo patológico y generar una nueva forma terapéutica. La primera transferencia se realizó en el año de 1989 en un paciente con una inmunodeficiencia. Aunque no se encontraron efectos clínicos se explicitó que tampoco había efectos deletéreos como muchos apocalípticamente habían pronosticado. En 1990 se trató con terapia génica un paciente que padecía de la deficiencia de la enzima adenosin-deaminasa presentando infecciones bacterianas a repetición.

    Aunque la mejoría fue temporal, con este ensayo se comprobó que la terapia génica tenía posibilidades terapéuticas reales....

  8. Estudio clínico-patológico de los efectos de la terapia fotodinámica en pacientes con queratosis actínicas de cuero cabelludo

    OpenAIRE

    Ughelly Champey, Gabriel Enrique

    2012-01-01

    La terapia fotodinámica (TFD) es una innovadora modalidad para el tratamiento de distintos tipos de cáncer cutáneo no melanoma (CCNM), entre ellos, las queratosis aclínicas (QA). Presenta también evidencia de su efectividad para la aparición de lesiones malignas y premalignas, especialmente en pacientes trasplantados con tratamiento inmunosupresor. Objetivos: El presente trabajo persigue describir los cambios histológicos y moleculares que subyacen a este efecto preventivo. Para ello se es...

  9. Influencia de polimorfismos genéticos, variables analíticas y ambientales en las concentraciones valle de terapia anti-TNF de pacientes con enfermedad inflamatoria intestinal

    OpenAIRE

    Romero Cara, Patricia

    2015-01-01

    OBJETIVOS La terapia anti-TNF-alfa está indicada en el tratamiento de las enfermedades inflamatorias crónicas. Cuando la respuesta es inadecuada se recomienda la intensificación de la dosis. Sin embargo, ni las razones para esta recomendación, ni los múltiples mecanismos implicados son bien conocidos. Nuestro objetivo principal es investigar si polimorfismos en los genes FCGRT, FCGR2A y FCGR3A (relacionados con el metabolismo y eliminación de inmunoglobulinas) ejercen una influencia en la ...

  10. Estudio de caso: terapia manual en una paciente de 18 años con escoliosis juvenil idiopática

    OpenAIRE

    Franco Monsalve, Claudia Yaneth; Guerra Corena, Zorika María; Otero Samudio, María Patricia

    2010-01-01

    La escoliosis es una desviación lateral de la columna vertebral desde la línea media, caracterizada por una curvatura lateral y por una rotación vertebral. Generalmente, es de carácter idiopático y se presenta, principalmente, en niñas adolescentes. Existen múltiples técnicas de tratamiento conservador para la escoliosis, entre las cuales se encuentran la terapia manual, que complementa el tratamiento para dicha patología. Esta terapia utiliza menos medios físicos, más manipulación de tejidos...

  11. The present status of I-131 therapy for Graves' hyperthyroidism in Japan. Survey by questionnaire

    International Nuclear Information System (INIS)

    Ikekubo, Katsuji; Kusakabe, Kiyoko; Kanaya, Shinichi; Nakada, Kunihiro; Mori, Yutaka

    2003-01-01

    A survey on the I-131 therapy of Graves' hyperthyroidism was undertaken by questionnaire in 1,246 hospitals of Japan. One thousand and ninety seven of them (88.0%) responded to the questionnaire. In this paper, we report the results and analysis of the replies to the questionnaire. In the 121 hospitals (11.03%) of the respondents, I-131 therapy is being performed for Graves' hyperthyroidism. A gradual increase was observed in the annual number of I-131 treated Graves' disease patients during the period of 1998-2001, from 1,740 to 2,484. I-131 treatment was selected mainly for the cases with side effects from antithyroid drug (ATD) therapy, followed by the cases with complication of heart or hepatic diseases, recurrences of hyperthyroidism after surgery, radioiodine treatment, and long-term ATD treatment. The 41% of respondents used I-131 in order to restore euthyroidism, 34% aimed for hyperthyroidism and 41% used the dose properly between the two according to the patients. Administration dosage of I-131 was estimated mainly on the basis of thyroid uptake and volume in 93% of the respondents and 48% calculated the radiation dose by also determining the effective half-life in the thyroid gland. Thyroid size was estimated by scintigram (51%), ultrasonography (US) (33%), CT (22%) and palpation (12%). ATD treatment was used before I-131 administration by 70% of the respondents and 34% after radioiodine therapy. A low-iodine diet was given to the patients for a week (46%) or two weeks (47%) before I-131 administration. However, after treatment only 46% of the respondents continued low-iodine diet for a week. (author)

  12. Software for dosimetry hypothyroid patients treated with I131 pick up and using probe gamma camera

    International Nuclear Information System (INIS)

    Jimenez Felstrom, D.; Luis simon, J.; Reyes Garcia, R.; Derecho Torres, P.; Herrador Cordoba, M.

    2015-01-01

    In this communication the process recently implemented in our hospital for pre and post treatment of patients treated with I-131 in benign diseases of the thyroid gland internal dosimetry is described. We have developed a proprietary software that facilitates the process of dosimetry. Through scans Planar or pictures Spect be determines the mass of the gland thyroid. In function of the mass, is calculated by Monte Carlo the media power absorbed by disintegration of the I-131 in said gland endocrine. (Author)

  13. Tc-99m imaging in thyroidectomized differentiated thyroid cancer patients immediately before I-131 treatment.

    Science.gov (United States)

    Tsai, Chi-Jung; Cheng, Cheng-Yi; Shen, Daniel Hueng-Yuan; Kuo, Shou Jen; Wang, Lien-Yen; Lee, Chiang-Hsuan; Wang, Jhi-Joung; Chang, Ming-Che; Huang, Wen-Sheng

    2016-02-01

    The aim of this study was to evaluate the clinical role of technetium-99m pertechnetate (Tc-99m) imaging in thyroidectomized differentiated thyroid cancer patients immediately before radioiodine-131 (I-131) treatment (Tx). Eighty-six consecutive post-total-thyroidectomy patients (15 men, 71 women; mean age: 46.8 years) with pathologically diagnosed differentiated thyroid cancer were retrospectively studied. Tc-99m imaging immediately before I-131 Tx using both patient-based and lesion-based measurements were analyzed and were further compared with those of post-Tx I-131 whole-body scans. For patients with unequivocally positive Tc-99m uptake, the sensitivity was 77% (patient-based) and 59% (site-based). The positive predictive value (PPV) was 100% for both patient-based and site-based measurements. If equivocal Tc-99m uptake was counted as positive, the sensitivity was 83 and 67%, and the PPV was 100 and 99% for patient-based and site-based measurements, respectively. (a) To increase sensitivity yet maintaining high PPV, equivocal Tc-99m uptake should be considered a positive finding. (b) The nearly 100% PPV of Tc-99m imaging immediately before I-131 Tx for remnant detection suggests that Tc-99m imaging not only serves as an alternative to low-dose I-131 scanning in the low-risk post-thyroidectomy patients but also provides a clue for the subsequent I-131 therapeutic dosage and even for the outcome prediction.

  14. Conversion factors in patient activity external rate Hp (10) in the patient environment in metabolic therapy with 1-131; Coeficientes de conversion actividad en pacientes a tasa externa Hp(10) en el entorno del paciente en terapia metabolica con I-131

    Energy Technology Data Exchange (ETDEWEB)

    Barquero Sanz, R.; Chambung, K.; Jaesseong, L.; Castillo Belmonte, A. del; Alonso Hernandez, D.; Andres Rodriguez, C.; Tortosa Oliver, R.; Mari Palacios, A.

    2011-07-01

    The purpose of this study is to determine the conversion factors (h) of R-131 to H measured in the patients environment, as the provision of activity in the same body or tumor, and analyzing the magnitude of the variables most significant influence on the measure of H. Applying the same procedure developed by the working group SEFM based on external exposure measurements made CHin taking the patient during their hospital stay, will optimize the procedure.

  15. Terapia ocupacional en medicina paliativa

    OpenAIRE

    Nicora, Yamila

    2009-01-01

    Terapia ocupacional interviene en el tratamiento de pacientes desde muy temprana edad (recién nacidos) hasta ancianos con déficit en el desempeño de alguna o todas las áreas ocupacionales: - Actividades de la vida diaria (AVD) básicas y personales - AVDI (instrumentales) - Educación - Trabajo - Juego - Ocio - Participación Social Se tienen en cuenta las habilidades de desempeño (motoras, de procesamiento...

  16. La terapia asistida por delfines y su implementación en niños con Síndrome de Down : una experiencia en Estados Unidos y México

    OpenAIRE

    Cortés Marco, Montserrat

    2016-01-01

    El propósito de esta Tesis Doctoral consiste en observación y análisis de la Terapia Asistida por delfines en niños con Síndrome de Down, con el fin de comprobar si hay una mejora en la evolución del lenguaje y la comunicación tanto a nivel mímico, verbal y visual, en las edades comprendidas entre los 5 meses y los 17 años de edad. Dicha práctica esta llevada a cabo a México y Estados Unidos respectivamente. Para poder llevar a cabo la observación se ha partido de la ejecución de unos ítems d...

  17. False-positive I-131 scan by contaminated muffler in a patient with thyroid carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Han Kyung; Kim, Min Woo; Jeong, Hwan Jeong; Sohn, Myung Hee [Chonbuk National University Hospital, Chonju (Korea, Republic of)

    2006-02-15

    A 39-year-old female patient who had undergone a total thyroidectomy for a papillary thyroid carcinoma underwent a whole body scan with I-131. The I-131 scan was performed 72 hours after administering 185 MBq (5 mGi) of an I-131 solution. The anterior image of head, neck, and upper chest showed multiple areas of increased uptake in the mediastinal area considering of functional metastasis. However, radioactivity was not evident in the image taken after removing her clothes and muffler. The image obtained after placing the muffler on the pallet showed that the radioactivity was still present. It is well known that artifacts on an I-131 scan can be produced by styling hair sputum, drooling during sleep, chewing gum, and paper or a cloth handkerchief that is contaminated with the radioactive iodine from either perspiration or saliva. This activity might be mistaken for a functional metastasis. Therefore, it is essential that an image be obtained after removing the patient's clothes. In this study, artifacts due to a contaminated muffler on the I-131 scan were found. These mimicked a functional metastasis of the mediastinal area in a patient with a papillary thyroid carcinoma.

  18. I131-MIBG in early diagnose of neuroblastoma in symptomatic children

    International Nuclear Information System (INIS)

    Saddadi, F.S.; Kargarzadeh, F.K.; Yaghoobi, N.Y.

    2002-01-01

    Aim: Neuroblastoma is the second most common solid tumors in childhood which derivates from neural crest. It is very malignant and almost always patient comes with metastasis. However there are some diagnostic tools to detection of lesion in the early stage of tumor. We decided to have a review with using I-131 MIBG in patients suspected and/or proved to have neuroblastoma. Material and Methods: 300-500 μci I 131 MIBG was injected intravenously in patients (5 patients with age range 4 years old) referred for their bone pain and pelvic mass(detected with anatomical tools). Images were obtained 24 to 72 hours throughout the body with ADAC gamma camera and SPECT was performed in each local abnormal uptake. Each patient has already had a WBBS with TcMDP. Results: All abnormal tracer uptakes were seen in bone scan were revealed clearly in I131 MIBG. However, three to five other abnormal tracer activities were only seen in MIBG scan. The main tumoral lesions were showed perfectly in pelvic,that was not seen in WBBS. With a statistical analysis, I131 MIBG has 94% sensitivity 85-100% specificity, compare to Tc99m-MDP that was 78% and 51% respectively. Conclusions: We found that I131 MIBG is the most useful method to diagnose of patients with neuroblastoma and reproved that it has a competitive role in management, follow-up of these tumors especially in detection of metastasis

  19. A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis

    International Nuclear Information System (INIS)

    Kunawudhi, Anchisa; Promteangtrong, Chetsadaporn; Chotipanich, Chanisa

    2016-01-01

    Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake at the thyroid bed. An additional total body scan with I-131 revealed a large radioiodine avid osteolytic bone metastasis with soft tissue masses and liver metastasis. The patient received treatment with total thyroidectomy, methimazole, and I-131 at a cumulative dose of 600 mCi along with recombinant human thyroid-stimulating hormone before the first I-131 treatment and palliative radiation. The patient had normal liver function test and experienced a mild degree of bone marrow suppression after I-131. At the 2-year follow-up, the patient was still alive with the progression of bone metastases but was doing well with less severe thyrotoxicosis, good ambulation, and an Eastern Cooperative Oncology Group performance status of 2. Clinicians should be aware of the unusual concurrent presentation of thyrotoxicosis and thyroid cancer, a differential diagnosis in patients with thyrotoxicosis and low or normal radioiodine uptake over the neck and also potential pitfalls during radionuclide treatment

  20. Radioimmunotherapy in refractory b-cell nonhodgkins lymphoma with I-131-labeled chimeric anti cd-20 c2b8 (I-131 rituximab): preliminary result

    International Nuclear Information System (INIS)

    Kang, Hye Jin; Park, Yeon Hee; Kim, Sung Eun and others

    2005-01-01

    Recently, the native chimeric human-mouse anti CD-20 antibody IDEC-C2B8 (Rituximab) has been widely applied in NHL. This ongoing phase study was to evaluate whether radioimmunotherapy (RIT) with I-131 rituximab is effective in refractory B-cell NHL. Inclusion criteria were as follows: B-cell NHL with relapsed or refractory to primary standard therapy, measurable disease, adequate hematologic, renal, and hepatic function, informed consent. The rituximab (Mabthera, Roach) was radiolabeled with iodine-131(I-131) using a modified chloramine T method with high radiochemical purity (95%) and preservation of immuno-reactivity. All patients received loading doses of unlabeled rituximab (median, 40 mg: range, 20∼70 mg) immediately prior to administration of therapeutic dose (51.4∼152.2 MBq/kg), and then underwent gamma camera scan. 11 patients were enrolled (4 low-grade B-cell NHL, 7 DLBCL, median age 63 years). Patients had received a median of three prior chemotherapy regimens. The objective response rate was 36.4% (1 CR, 3 PRs). These all responses were observed in low-grade B-cell NHL, except one with DLBCL. Adverse events were primarily hematologic toxicities; the incidence of grade 3/4 neutropenia, thrombocytopenia, and anemia was 27.3%, 45.5%, and 18.2%, respectively. The treatment-related mortality was observed in one patient, who had been previously treated with high-dose chemotherapy plus TBI with autologous stem cell transplantation. RIT with I-131 rituximab seems to be effective tolerable in refractory low-grade B-cell NHL, although modest activity in refractory DLBCL. Further studies to define the efficacy of I-131 rituximab in DLBCL are warranted

  1. Radioimmunotherapy in refractory b-cell nonhodgkins lymphoma with I-131-labeled chimeric anti cd-20 c2b8 (I-131 rituximab): preliminary result

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hye Jin; Park, Yeon Hee; Kim, Sung Eun and others [Korea University Medical School, Seoul (Korea, Republic of)

    2005-07-01

    Recently, the native chimeric human-mouse anti CD-20 antibody IDEC-C2B8 (Rituximab) has been widely applied in NHL. This ongoing phase study was to evaluate whether radioimmunotherapy (RIT) with I-131 rituximab is effective in refractory B-cell NHL. Inclusion criteria were as follows: B-cell NHL with relapsed or refractory to primary standard therapy, measurable disease, adequate hematologic, renal, and hepatic function, informed consent. The rituximab (Mabthera, Roach) was radiolabeled with iodine-131(I-131) using a modified chloramine T method with high radiochemical purity (95%) and preservation of immuno-reactivity. All patients received loading doses of unlabeled rituximab (median, 40 mg: range, 20{approx}70 mg) immediately prior to administration of therapeutic dose (51.4{approx}152.2 MBq/kg), and then underwent gamma camera scan. 11 patients were enrolled (4 low-grade B-cell NHL, 7 DLBCL, median age 63 years). Patients had received a median of three prior chemotherapy regimens. The objective response rate was 36.4% (1 CR, 3 PRs). These all responses were observed in low-grade B-cell NHL, except one with DLBCL. Adverse events were primarily hematologic toxicities; the incidence of grade 3/4 neutropenia, thrombocytopenia, and anemia was 27.3%, 45.5%, and 18.2%, respectively. The treatment-related mortality was observed in one patient, who had been previously treated with high-dose chemotherapy plus TBI with autologous stem cell transplantation. RIT with I-131 rituximab seems to be effective tolerable in refractory low-grade B-cell NHL, although modest activity in refractory DLBCL. Further studies to define the efficacy of I-131 rituximab in DLBCL are warranted.

  2. Evaluation of systematic I-131 thyroid measurements for nuclear medicine workers

    International Nuclear Information System (INIS)

    Puscalau, M.A.

    2002-01-01

    In Nuclear Medicine, I-131 is used intensively for the diagnosis and for the treatment of the different severities maladies of the thyroid. This radionuclide generates an important internal contamination to the patients, because of its oral administration, and, also, through inhalation, to the workers involved in the radiopharmaceuticals production , to the nursing staff and to the physicians that care and treat the patients in the hospitals. The paper presents the data obtained by systematically thyroid monitoring of the physicians and nurses from the Endocrinology Hospital, that are contaminated by I-131 inhalation because of their permanent relation with the patients treated with 3.7 MBq I-131 for investigation and with activities in the range 1100 MBq - 4000 MBq for therapy. The measurements were carried out with our Body Counter equipped with a NaI(Tl) scintillation detector, 50 mm thickness and 40mm diameter. Values of the estimated committed equivalent doses are, also, reported

  3. Testicular impact of the treatment with I-131 in patients with differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Chebel, G.; Gutierrez, S.; Fadel, A.; Suarez, S.; Levalle, O.

    2007-01-01

    Young patients carriers differentiated thyroid carcinoma (DTC) are treated with high doses of I-131 for much of his life with very good prognosis and projects with paternity. However, there is scarce information on the effect of radioiodine on the male gonad and their future fertility. This therapy may compromise on a temporary and / or definitively the role of the germinal cells. The testicular irradiation depends on the blood flow, the dose of I-131 administered and of the presence or absence of metastasis pelvic near to the gonads. A single dose of 100 mCi of I-131 throws an absorbed dose at gonadal level of 50-150 cGy. It has been reported that absorbed doses of 50 cGy can produce transitory decrease spermatogenesis and higher doses can also affect the function of the Leydig cells [es

  4. Calculation of the activity incorporated in the therapy with I 131

    International Nuclear Information System (INIS)

    Chica, L.G.; Puerta, J.A.

    1998-01-01

    By means of the product S(T--S). A-s-(T-e-). the absorbed dose to thyroid delivered by I-131 incorporated is calculated. Where S(T--S) is the absorbed dose in the thyroid per nuclear transformations (tn.) of I-131 localized in the thyroid and as a potential function of the mass is expressed. A-s-(T-e-) is the number of tn. of I-131 in the thyroid since the moment of the incorporation until the time T-e- (the effective middle time); to find A-s-(T-e-) to normal as different pathological conditions, the metabolic model of the iodo proposed by the ICRP is used. Of the expression of the doses, the incorporated activity, I-o- is obtained

  5. Estimation of foetal brain dose from I-131 in the foetal thyroid

    International Nuclear Information System (INIS)

    O'Hare, N.J.; Murphy, D.; Malone, J.F.; Gilligan, P.

    1997-01-01

    The ingestion of I-131 by pregnant women can have consequences for the developing foetus, in particular brain function. As the foetal thyroid accumulates iodine from the twelfth week of gestation onwards, the determination of foetal brain dose resulting from such I-131 accumulation is essential. Normal dosimetric methods fail to treat the case of the foetus. Using an approximation method based on the MIRD approach, a foetal dose estimation scheme is developed to allow the determination of foetal brain dose from foetal thyroid irradiation. Dose values are obtained for the foetus based on the maternal intake of I-131. It was found that the choice of biokinetic model for the mother/foetus has a large impact on the determined dose estimate. (author)

  6. The therapeutic use of I-131 meta-iodobenzylguanidine (MIBG) in neuroblastoma

    International Nuclear Information System (INIS)

    Hartmann, O.; Lumbroso, J.D.; Lemerle, J.; Schlumberger, M.; Parmentier, C.; Ricard, M.; Aubert, B.; Coornaert, S.; Merlin, L.

    1988-01-01

    Despite the use of intensified conventional chemotherapy the complete response rate of advanced neuroblastoma remains low. The use of high-dose chemo-radiotherapy followed by bone marrow transplantation (BMT) improved the duration of disease free survival but, even after these high-dose regimens the relapse rate remains high. Metaiodobenzylguanidine (MIBG) labelled with I-131 or I-123 can be used for scintigraphic imaging of neuroblastoma. In order to evaluate the therapeutic role of I-131-MIBG in the treatment of neuroblastoma patients, a phase II study was performed in 12 patients. Results are presented in this paper

  7. Varianti genetiche associate al rimodellamento inverso dopo terapia di resincronizzazione cardiaca

    OpenAIRE

    De Maria, Renata; Lunati, M.; Landolina, M.; Gasparini, M.; Schmitz, Boris; Sanzo, A.; Galimberti, P.; Campolo, J.; Parolini, M.; Brand, S.M.; Parodi, O.

    2011-01-01

    In pazienti con scompenso cardiaco cronico sistolico (HF) la terapia di resincronizzazione cardiaca (CRT) determina effetti favorevoli sulle dimensioni e la funzione ventricolare noti come rimodellamento inverso (RR).

  8. Psicoterapia Analítico-Funcional y Terapia de Aceptación y Compromiso: teoría, aplicaciones y continuidad con el análisis del comportamiento

    Directory of Open Access Journals (Sweden)

    Robert J. Kohlenberg

    2005-01-01

    Full Text Available El análisis funcional del comportamiento verbal de tradición skinneriana ha encontrado desarrollos recientes en modelos de intervención conductual que son objeto de exposición y análisis en el presente estudio teórico. La Psicoterapia Analítico- Funcional (PAF se fundamenta en el análisis y moldeamiento del comportamiento verbal del paciente en tiempo real durante las sesiones de intervención. En este caso, la relación terapéutica se considera un modelo de relación interpersonal a generalizar a la vida diaria del cliente. La PAF ofrece un análisis conductual de la relación terapeuta-paciente y de su importancia en el proceso clínico, así como un marco teórico para el análisis de los efectos sinérgicos derivados de su combinación con terapias cognitivas o cognitivo-conductuales tradicionales. Por otro lado, la Terapia de Aceptación y Compromiso (ACT aborda los trastornos del comportamiento y las emociones enfatizando el análisis de la evitación de eventos privados aversivos (por ejemplo, evitación experiencial como función de una pluralidad de comportamientos de topografía «psicopatológica». Estos procesos pueden verse coadyuvados por el seguimiento de reglas verbales relativas al control estricto de emociones y cogniciones. La ACT ofrece varias herramientas clínicas para desmontar los procesos de evitación y de seguimiento de reglas asociados al problema del paciente. Finalmente, ambos modelos son analizados en términos de su continuidad teórica con el análisis funcional del comportamiento y el análisis de conducta tradicionales.

  9. Entrenamiento de la capacidad aeróbica por medio de la terapia acuática en niños con parálisis cerebral tipo diplejía espástica

    Directory of Open Access Journals (Sweden)

    Nandy Fajardo López

    2013-10-01

    Full Text Available Antecedentes. La parálisis cerebral tipo diplejía espática genera cambios en el sistema cardiovascular que afectan la capacidad aeróbica. La terapia acuática es una estrategia terapéutica óptima tanto para el manejo de la población como para el entrenamiento de la capacidad aeróbica, por las respuestas fisiológicas que genera y porque brinda la facilidad de generar mayores cargas al sistema cardiovascular con menores riesgos que en tierra. Objetivo. Identificar las características que debe tener una propuesta de intervención fisioterapéutica para el entrenamiento de la capacidad aérobica en niños y niñas entre los 8 y los 12 años, con parálisis cerebral tipo diplejía espástica, empleando la terapia acuática. Materiales y métodos. Se desarrolló un estudio de tipo descriptivo-propositivo, en el cual se formuló una propuesta de intervención basada en información recolectada a través de referencias bibliográficas. Resultados. Se presentan en forma de propuesta de intervención, describiendo en detalle las fases del entrenamiento de la capacidad aeróbica, mediante los principios del entrenamiento y la prescripción de ejercicio físico, teniendo en cuenta las respuestas fisiológicas ante la carga, así como las características propias de la población. Conclusión. La parálisis cerebral tipo diplejía espástica, genera cambios en la capacidad aeróbica; por esto, el fisioterapeuta debe incluirla en los procesos de rehabilitación como uno de sus objetivos. Para lograrlo, la terapia acuática es una modalidad de tratamiento óptima, puesto que genera mayor seguridad de movimiento y respuestas fisiológicas favorables en el sistema cardiovascular.

  10. Recurrence rates following I-131 therapy of differentiated thyroid carcinoma: results of meta-analysis

    International Nuclear Information System (INIS)

    Obaldo, J.M.

    1990-01-01

    To examine the efficacy of I-131 therapy in decreasing recurrence rates after surgery for differentiated thyroid carcinoma, a research tool called meta-analysis was used. Data were pooled from five published studies which evaluated recurrences following at least sub-total thyroidectomy with or without I-131 ablation of remnants. Of 1332 patients managed surgically only 202 (15%) developed recurrences compared to 36 of 339 (11%) treated with radioiodine. This difference was statistically significant at p<.05. When a separate analysis of only those studies which directly compared the two modes of management was conducted, recurrence rates for patients treated by surgery alone was higher at 18% (185 of 1034) compared with those who had subsequent I-131 therapy with a rate of 9% (27 of 297). This difference was again significant at p <.001. This meta-analysis strongly suggests that the use of I-131 for ablation of post-surgical thyroid remnants significantly reduces recurrence rates in patients with differentiated thyroid carcinoma. (Auth.). 34 refs., 1 tab.; 1 fig

  11. Renal I-131-hippurate clearance overestimates true renal blood flow in the instrumented conscious dog

    NARCIS (Netherlands)

    Visscher, CA; DeZeeuw, D; Navis, G; VanZanten, AK; DeJong, PE; Huisman, RM

    We evaluated renal I-131-hippurate clearance (ERPF(hip)) as a measure of renal blood flow (RBF) in chronically instrumented conscious dogs. When adjusted for renal hippurate extraction (E(hip), 0.77 +/- 0.01) and hematocrit (Hct, 39.7 +/- 1%), calculated RBF(hip) (656 +/- 37 ml/min) markedly

  12. 76 FR 81517 - Agency Information Collection Activities: Form I-131, Revision of an Existing Information...

    Science.gov (United States)

    2011-12-28

    ... information collection. (2) Title of the Form/Collection: Application for Travel Document. (3) Agency form... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information...-Day Notice of Information Collection Under Review: Form I- 131, Application for Travel Document. The...

  13. 77 FR 15787 - Agency Information Collection Activities: Form I-131, Revision of an Existing Information...

    Science.gov (United States)

    2012-03-16

    ... the Form/Collection: Application for Travel Document. (3) Agency Form Number, if any, and the... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information...-Day Notice of Information Collection Under Review: Form I- 131, Application for Travel Document. The...

  14. Evaluation of results of more than 20 years treating hyperthyroidism by I-131

    International Nuclear Information System (INIS)

    Phan, S.A.; Mai, T.K.; Tran, D.H.

    2001-01-01

    The authors have summarized their works of more than 20 years using I-131 for treatment and close observation of 723 patients with hyperthyroidism in 1000 ones in the Nuclear Medicine Department, Bach Mai University Hospital in Hanoi to collect data and draw experience for the report. Patient selection for the treatment is based on clinical features and laboratory tests results by the Nuclear Medicine Department such as thyroid uptake, scintigraphy and RIA determinations of thyroid hormones. I-131 dose is determined in compliance with a prevailing formula. The average dose is 6.2 ± 1.1 mCi (that is 233.1 ± 40.7 MBq). The average number of times is 1.3 time for one patient. The results are as follows: Euthyroid status after 4- year following- up from date of I-131 dose administration: 72.3%; Persistent or recurrent hyperthyroidism: 20.0%; Hypothyroid complications: appear 4 to 12 months after date of I-131 administration: 3.0%; appear 4 years after date of I-131 administration: 7.7%; appear 6 years after date of I-131 administration. 14.0%; so the cumulative hypothyroid rate is 2.3% per year. No occurrence of other serious complications by all the observed patients. This is therefore a safe, efficient treatment method to be applied on a large scale including adolescents and children. However, much more study has still to be made on the dose due to high rate of recurrence of the therapeutic method although the hypothyroid complications cases are not serious. Hyperthyroidism is a common health problem in Viet Nam. Previously, only anti-thyroid drugs and surgery were used. Use of I-131 was firstly introduced to Viet Nam in the Nuclear Medicine Department in Bach Mai in 1974 and afterwards applied larger nationwide. Initial therapeutic results have been published in national medical magazines. This is a general study aiming at analyzing the way to carry out the work and get experience and recommendation from gained results for further work in the future. (author)

  15. Is it safe to treat hyperthyroid patients with I-131 without fear of thyroid storm?

    International Nuclear Information System (INIS)

    Vijayakumar, V.; Nusynowitz, M.L.; Ali, S.

    2006-01-01

    Thyroid storm is extremely rare. However, hyperthyroid patients with severe thyrotoxicosis are frequently not treated immediately with I-131 for fear of thyroid storm but are placed on thiouracil drugs for varying periods of time. We demonstrate herein that it is safe to treat these patients with I-131, without pretreatment with thiouracil drugs, provided they do not have complicating intercurrent disease. Our definition of severe hyperthyroidism includes marked signs and symptoms of thyrotoxicosis, suppressed thyroid stimulating hormone (TSH), markedly elevated free T4 and/or free T3 and elevated radioactive iodine uptake (RAIU) (>30%) at 4 or 24 hours. Our diagnostic criteria for thyroid storm include two or more findings of fever (>38 deg C, 100 deg F), severe tachycardia, high pulse pressure, agitation with tremors, flushing, sweating, heart failure, nausea, vomiting, diarrhea, jaundice associated with high free T4 and/or free T3. Patients were selected retrospectively for the period between August 2003 and December 2004. One hundred and twenty-two patient visits were identified. These patients were treated with 370-740 MBq (10-20 mCi) of I-131 and were evaluated for any evidence of thyroid storm. Most of the patients were placed on beta blocker drugs at the time of initial I-131 therapy; these were continued for at least two months, when the first follow-up visit occurred. At the time of I-131 therapy, it is our policy to educate the patients to seek immediate medical attention for exacerbation of symptoms of thyrotoxicosis. Not one of these patients developed thyroid storm. A subset of 25% of these cases with higher potential for thyroid storm (RAIU more than 65%, very marked signs and symptoms, and very markedly elevated free T4 and/or free T3) also tolerated the I-131 therapy well with marked clinical improvement and no exacerbation of the thyrotoxic state. It is safe to administer I-131 to patients who are severely hyperthyroid without fear of thyroid

  16. The biodistribution and effect on hepatic parenchyma with intraarterial injected I-131 lipiodol into hepatic artery

    International Nuclear Information System (INIS)

    Kim, Dong Ik; Suh, Jung Ho; Yoo, Hyung Sik; Lee, Jong Tae; Kim, Ki Whang; Park, Chan Il; Kim, Byung Ro

    1989-01-01

    Iodized oil has been used as a contrast agent in lymphangiography. One of the commercially available compounds is Lipidol Ultra-fluid(LUF) which contains 38% iodine by weight. Nakakuma et al(1979) reported that LUF was selectively retained in the hypervascular hepatocellular carcinoma when injected directly into the ligated hepatic artery. Since that time, it has been widely utilized in the detection as well as the therapeutic attempts of hepatocellular carcinoma, where it has been mixed with chemotherapeutic agents or labeled with radioactive I-131. Like all significant advances, the mechanism of lipid retention within the hepatocellular carcinoma is not clearly understood, and also there is a lack of information about the biodistribution and kinetics of I-131 Lipiodol. The apparent safety of this technique require confirmation. The present study was aimed to assess the biodistribution and kinetics of intraarterially injected I-131 Lipiodol and the histologic changes in canine livers. It was also to verify the safety of this technique in clinical applications. Radioactive iodized oil was obtained by simple exchange method . 518 ± 19 MBq(14 mCi, about 1 mCi/kg body weight) of I-131 Lipiodol was injected intraarterially in 12 dogs as a experimental group. Serial count rates over the livers under gamma camera were measured, and then it was compared with quantitative analysis of radioactivities distributed in liver, lung, spleen, kidney, thyroid, bile and circulating blood using dose calibrator after sacrifice at various time intervals. Cumulative radiation doses were calculated by Quimby method. The effect of I-131 lipiodol on hepatic function were analysed by serial liver function tests after intrahepatic injection of I-131 Lipiodol and compared with preinjection values. Liver tissue obtained after sacrifice were stained with hematoxylin-eosin, Oil red-O, and also election microscopic examinations were performed. The results were summarized as follows; 1

  17. I-131 therapy for thyroid diseases: Doses, new regulations and patient advice

    International Nuclear Information System (INIS)

    Amaral, H.; Michaud, P.

    2001-01-01

    I-131 therapy has been widely used in the past 50 years. Its main applications are hyperthyroidism and functioning thyroid cancer. The indications, doses, regulations, precautions and guidelines differ in various centers. The following are recommended: 1. I-131 should be indicated in agreement of the endocrinologist and the nuclear physician with the patient consent; 2. Pre-treatment I-131 thyroid uptake must be performed; 3. The only contraindication for treatment is pregnancy, in children it might be used with caution; 4. For thyrotoxicosis both a calculated or an ablative dose (555 MBq) criteria are acceptable In this case secondary hypothyroidism must be considered an objective rather than a complication; 5. In uninodular toxic goiter a 1110 MBq dose is recommended; 6. Iodine free diet is indicated only for cancer patients; 7. Propylthiouracil (PTU) must be discontinued 5 days before treatment, it should be reinitiated 5 days later; 8. Prophylactic use of corticoid in Graves' disease still require more clinical data to support its use; 9. In treatment failure, wait six months for a new dose; 10. In intrathyroid cancer disease an ablative dose of 3700 MBq should be administered 4 weeks post-thyroidectomy or with a TSH level above 30 μUI/mL; 11. A whole body scan should be done one week later; 12. Follow-up whole body scan should be used only if there is clinical suspicion of metastasis. Thyroid hormone replacement must be discontinued for 30 days or with TSH value above 30 I/mL. For follow-up scan 185 MBq of I-131 are recommended to ovoid thyroid tissue stunning; 13. For metastases, 5700 to 7400 MBq dose is recommended if there are cervical lymphatic nodes or distant metastases. We recommended to adopt the criteria proposed by the United States Nuclear Regulatory Commission (NRC) published as 10 CFR 35.75 and the Regulatory Guide 8.39 for patients release after I-131 administration. (author)

  18. Efficiency of radioiodine therapy with a fix dose of I-131 in toxic thyroid adenoma

    International Nuclear Information System (INIS)

    Petrovski, Z

    2004-01-01

    Purpose: The aim of this study was to estimate the results obtained using a fix dose of I-131 in the treatment of the solitary toxic thyroid adenoma. Material and Methods: We have performed radioiodine therapy m 64 patients, 49 female (50+ 1 7 yrs) and 15 male (43+-15 yrs) with solitary toxic thyroid adenoma. 45 patients received fix dose I-131 of 850 MBq, while 19 patients were treated with calculated (MBq/gr) dose 555-1100 MBq Previously 39(64%) patients were clinically hyperthyreotic and received thyreostatic meditication which were interruptecf one week before the administration of I-131. Those patients who were euthyreotic, TSH was suppressed(<0.25 MU/m1). 61(95.3%) patients received a single dose, while 3(4, 7%) patients needed two doses. Resulting thyroid matabolism and volume of nodules were evaluated 6-48 months after treatment. Results: From 45 radioiodine treated patients with fix dose 6(9, 8%) became hypothyroidism, 36(85, 3%) euthyroidism and 3(4, 9%) recurrent hyperthyroidism, in comparison with 19 treated patients with calculated I-131 dose: 2(10, 5%) hypothyroidism, 16(84, 3%) euthyroidism and 1(5, 2%) recurrent hyperthyroidism. The size of the nodules became unpalpable m 17(26, 2%), decreased evidently in 33(52, 5%) and remained unchanged in 14(21, 3%) of the treated patients. Conclusion: A fix dose of I-131 is simple, safe and efficient in the treatment of solitary toxic thyroid adenoma. There was not significant different in incidence of late follow-up results of hypothyroidism and recurrent hyperthyroidism between fix dose and calculated MBq/gr dose. (authors)

  19. Radiation Dose-rate Reduction Pattern in Well-differentiated Thyroid Cancer Treated with I-131.

    Science.gov (United States)

    Khan, Shahbaz Ahmad; Khan, Muhammad Saqib; Arif, Muhammad; Durr-e-Sabih; Rahim, Muhammad Kashif; Ahmad, Israr

    2015-07-01

    To determine the patterns of dose rate reduction in single and multiple radioiodine (I-131) therapies in cases of well differentiated thyroid cancer patients. Analytical series. Department of Nuclear Medicine and Radiation Physics, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), Multan, Pakistan, from December 2006 to December 2013. Ninety three patients (167 therapies) with well differentiated thyroid cancer treated with different doses of I-131 as an in-patient were inducted. Fifty four patients were given only single I-131 therapy dose ranging from 70 mCi (2590 MBq) to 150 mCi (5550 MBq). Thirty nine patients were treated with multiple I-131 radioisotope therapy doses ranging from 80 mCi (2960 MBq) to 250 mCi (9250 MBq). T-test was applied on the sample data showed statistically significant difference between the two groups with p-value (p < 0.01) less than 0.05 taken as significant. There were 68 females and 25 males with an age range of 15 to 80 years. Mean age of the patients were 36 years. Among the 93 cases of first time Radio Active Iodine (RAI) therapy, 59 cases (63%) were discharged after 48 hours. Among 39 patients who received RAI therapy second time or more, most were discharged earlier after achieving acceptable discharge dose rate i.e 25 µSv/hour; 2 out of 39 (5%) were discharged after 48 hours. In 58% patients, given single I-131 therapy dose, majority of these were discharged after 48 hours without any major complications. For well differentiated thyroid cancer patients, rapid dose rate reduction is seen in patients receiving second or subsequent radioiodine (RAI) therapy, as compared to first time receiving RAI therapy.

  20. Radioiodine (I-131) treatment for uncomplicated hyperthyroidism: An assessment of optimal dose and cost-effectiveness

    International Nuclear Information System (INIS)

    Paul, A.K.; Rahman, H.A.; Jahan, N.

    2002-01-01

    Aim: Radioiodine (I-131) is increasingly being considered for the treatment of hyperthyroidism but there is no general agreement for the initial dose. To determine the cost-effectiveness and optimal dose of I-131 to cure disease, we prospectively studied the outcome of radioiodine therapy of 423 patients. Material and Methods: Any of the fixed doses of 6, 8, 10, 12 or 15 mCi of I-131 was administered to the patients relating to thyroid gland size. The individual was excluded from this study who had multinodular goitre and autonomous toxic nodule. Patients were classified as cured if the clinical and biochemical status was either euthyroid or hypothyroid at one year without further treatment by antithyroid drugs or radioiodine. The costs were assessed by analyzing the total cost of care including office visit, laboratory testing, radioiodine treatment, average conveyance and income loss of patient and attendant and thyroxine replacement for a period of 2 years from the day of I-131 administration. Results: The results showed a progressive increase of cure rate from the doses of 6, 8 and 10 mCi by 67%, 76.5% and 85.7% respectively but the cure rate for the doses of 12 and 15 mCi was 87.9% and 88.8% respectively. Cure was directly related to the dose between 6 and 10 mCi but at higher doses the cure rate was increased marginally at the expense of increased total body radiation. There was little variation in total costs, but was higher for low dose-therapy and the cost proportion between the 6 mCi regimen and 10 mCi regimen was 1.04:1. Conclusion: We could conclude that an initial 10 mCi of I-131 may be the optimal dose for curing hyperthyroidism and will also limit the total costs

  1. Terapias cognitivo-conductuales en la fobia social, en adultos

    OpenAIRE

    San Vicente Montalbán, Ainara

    2015-01-01

    La fobia social es una enfermedad psiquiátrica que causa costes socioeconómicos significativos y que presenta una alta comorbilidad. Las terapias cognitivo-conductuales (TCC) pueden ser una alternativa de tratamiento efectiva, ya que buscan el cambio de pensamientos y comportamientos adquiridos en una enfermedad con un alto componente de aprendizaje. Objetivo: Verificar la efectividad de las terapias cognitivo-conductuales (TCC) con respecto a otros tratamientos empleados en la fobia soci...

  2. Preparation of a radioactive boron compound (B-I-131-lipiodol) for neutron capture therapy of hepatoma

    International Nuclear Information System (INIS)

    Chou, F.I.; Chung, H.P.; Chung, R.J.; Wen, H.W.; Wei, Y.Y.; Kai, J.J.; Lui, W.Y.; Chi, C.W.

    2000-01-01

    In our research, a radioactive boron compound, B-I-131-lipiodol, that can be selectively retained in hepatoma cells was prepared. Combining the effect of α particles produced by boron neutron capture reaction with the β particles released by radionuclides in the radioactive boron compounds will produce a synergistic killing effect on cancer cells. Human hepatoma HepG2 cell cultures were used to examine the stability and the intracellular distribution of the radioactive boron drug. Microscopes were used to examine the interaction and retention of B-I-131-lipiodol globules in the individual hepatoma cell. Moreover, ICP-AES and NaI scintillation counter were performed to determine boron concentrations and I-131 radioactivity, respectively. Results showed that B-I-131-lipiodol with a boron concentration and a specific radioactivity ranged from 500-2000 ppm and 0.05-10 mCi/mL respectively was stably retained in serum. The radiochemical purity of B-I-131-lipiodol was 98%. After supplement with a medium containing B-I-131-lipiodol, the HepG2 cells had intracellular B-I-131-lipiodol globules in the cytoplasm as seen by inverted light microscope, the I-131 and boron can be stably retained in HepG2 cells. (author)

  3. Differentiated Thyroid Carcinoma After I-131-MIBG Treatment for Neuroblastoma During Childhood: Description of the First Two Cases

    NARCIS (Netherlands)

    van Santen, Hanneke M.; Tytgat, Godelieve A. M.; van de Wetering, Marianne D.; van Eck-Smit, Berthe L. F.; Hopman, Saskia M. J.; van der Steeg, Alida F.; Nieveen van Dijkum, Els J. M.; van Trotsenburg, A. S. Paul

    2012-01-01

    Background: It is well known that the thyroid gland is sensitive to the damaging effects of irradiation (X-radiation or I-131(-)). For this reason, during exposure to I-131-metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), the thyroid gland is protected against radiation damage by

  4. Indication of doxorubicin cardiotoxicity by impairment of pIPPA I 131 utilization

    International Nuclear Information System (INIS)

    Lenzhofer, R.; Dudczak, R.

    1986-01-01

    The present study was designed to evaluate if doxorubicin (D) can impair myocardial fatty acid utilization. To this end we studied the myocardial utilization of pIPPA I 131 in untreated (Co, n=6) and D (20 mg/kg intraperitoneal) treated rats. D was given 24 h (24 D, n=6) and 48 hours (48 D, n=6) before tracer administration. One min after i.v. pIPPA I 131 (50 μCi) injection, the hearts were rapidly removed, frozen in liquid nitrogen, weighed, and counted. Following lipid extraction of homogenized heart extracts 131 I radioactivity distribution was analyzed by thin-layer chromatographity (TLC). In additional rat experiments, high energy phosphates (12 rats/group) and carnitine (20 rats/group) were determined enzymatically in heart extracts. The mean pIPPA uptake in rat heart (%dose/g) was 2.49 in Co, 1.74 in 24 D, and 2.36 in 48 D rats. Usually five peaks were separated by TLC, that with a mean Rf value of 0.92 corresponding to pIPPA I 131, the remaining four representing catabolites of pIPPA metabolism. The mean relative amount of unmetabolized pIPPA I 131 as compared to the sum of pIPPA I 131 catabolites was less in Co than in 24 D or 48 D rats (P<0.05) (anti x: 46.5% vs 72.4% vs 59.4%, respectively). The mean carnitine content of H extracts was higher in Co (0.55 μM/g) than in D treated rats (24 D, 0.42 μM/g; 48 D, 0.46 μM/g) (P<0.05). The total amount of higher energy phosphates was not different between the groups. However the mean ATP/AMP ratio was higher in Co (35.9) than in 24 D (22.3) or 48 D (27.1) rats (P<0.05). We conclude that D therapy is accompanied by a partial reversible impairment in myocardial pIPPA utilization, possibly mediated by carnitine deficiency. Thus, pIPPA I 131 might be useful in patients on D therapy to evaluate eventual D-induced effects on myocardial fatty acid utilization. (orig.)

  5. Development of gamma-photon/Cerenkov-light hybrid system for simultaneous imaging of I-131 radionuclide

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi; Suzuki, Mayumi; Kato, Katsuhiko [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine (Japan); Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine (Japan); Ogata, Yoshimune [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine (Japan); Hatazawa, Jun [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine (Japan)

    2016-09-11

    Although iodine 131 (I-131) is used for radionuclide therapy, high resolution images are difficult to obtain with conventional gamma cameras because of the high energy of I-131 gamma photons (364 keV). Cerenkov-light imaging is a possible method for beta emitting radionuclides, and I-131 (606 MeV maximum beta energy) is a candidate to obtain high resolution images. We developed a high energy gamma camera system for I-131 radionuclide and combined it with a Cerenkov-light imaging system to form a gamma-photon/Cerenkov-light hybrid imaging system to compare the simultaneously measured images of these two modalities. The high energy gamma imaging detector used 0.85-mm×0.85-mm×10-mm thick GAGG scintillator pixels arranged in a 44×44 matrix with a 0.1-mm thick reflector and optical coupled to a Hamamatsu 2 in. square position sensitive photomultiplier tube (PSPMT: H12700 MOD). The gamma imaging detector was encased in a 2 cm thick tungsten shield, and a pinhole collimator was mounted on its top to form a gamma camera system. The Cerenkov-light imaging system was made of a high sensitivity cooled CCD camera. The Cerenkov-light imaging system was combined with the gamma camera using optical mirrors to image the same area of the subject. With this configuration, we simultaneously imaged the gamma photons and the Cerenkov-light from I-131 in the subjects. The spatial resolution and sensitivity of the gamma camera system for I-131 were respectively ~3 mm FWHM and ~10 cps/MBq for the high sensitivity collimator at 10 cm from the collimator surface. The spatial resolution of the Cerenkov-light imaging system was 0.64 mm FWHM at 10 cm from the system surface. Thyroid phantom and rat images were successfully obtained with the developed gamma-photon/Cerenkov-light hybrid imaging system, allowing direct comparison of these two modalities. Our developed gamma-photon/Cerenkov-light hybrid imaging system will be useful to evaluate the advantages and disadvantages of these two

  6. Initial radioiodine remnant ablation success rates compared by diagnostic scan methods: I123 versus I131

    International Nuclear Information System (INIS)

    Choi, W.; Choi, E.; Yoo, I.; Kim, S.; Han, E.; Lee, S.; Lee, W.

    2015-01-01

    Full text of publication follows. Objective: to see if diagnostic whole body scan (DxWBS) performed with I-131 prior diminishes the success rate of initial radioiodine remnant ablation (RRA) compared to I-123 DxWBS in differentiated thyroid cancer patients. Material and methods: consecutive thyroid cancer patients who received total thyroidectomy for differentiated thyroid cancer and then high dose RRA (either 100 mCi or 150 mCi) within 6 months were included. DxWBSs were performed with I-123 or with I-131. Prior to the DxWBSs, all patients followed strict low iodine diet for 2 weeks and withdrew hormone to stimulate TSH above 30 mIU/l. Patients with extra-thyroidal extension of tumor, lymph node metastasis, or distant metastasis were excluded. The initial RRA was defined as successful if the next DxWBS done 6 months to 1 year later was negative and stimulated thyroglobulin level was below 2 ng/ml. Results: of 71 patients who had I-123 DxWBSs, 31 patients went on to receive RRA with 100 mCi and 40 patients received 150 mCi. Of 73 patients who had I-131 DxWBSs, 66 received 100 mCi and 7 patients received 150 mCi. The overall success rate was 79% for patients who had I-123 DxWBS prior to RRA (68% for 100 mCi and 86% for 150 mCi), and 68% for patient who had I-131 DxWBSs (68% for 100 mCi and 71% for 150 mCi). Conclusion: for patients who received 100 mCi, the RRA success rate was the same for I-123 DxWBS and I-131 DxWBS. For patients treated with 150 mCi, the success rate may be lower in patients who receive RRA following DxWBS with I-131 compared to DxWBS with I-123. (authors)

  7. Terapia conductual dialéctica

    OpenAIRE

    Gempeler, Juanita

    2008-01-01

    Introducción: Un importante aporte de la terapia cognoscitivo-comportamental al área clínica es la terapia conductual dialéctica (TCD), desarrollada a finales de los años noventa por la psiquiatra Marsha Linehan, como respuesta a las dificultades en el tratamiento del trastorno de personalidad limítrofe (TPL). Se destaca su carácter integrador, pues se basa en principios conductuales y cognoscitivos e incorpora elementos del zen. Es un tratamiento desarrollado y evaluado con mujeres que no só...

  8. Comparison of F-18 FDG PET and I-131 whole body scan in diagnosis of suspicious metastatic thyroid carcinoma

    International Nuclear Information System (INIS)

    Seok, Ju Won; Chung, June Key

    2005-01-01

    There are several reports about the usefulness of F-18 FDG PET in thyroid cancer. The aim of this study was to evaluate the effectiveness of F-18 FDG PET and I-131 whole body scan in suspicious metastatic thyroid cancer. There were 46 patients (11 men, 35 women; age range, 18-74yr; mean age, 47.3yr) with suspicious metastatic thyroid cancer after total thyroidectomy who performed FDG PET and I-131 scan. The interval of FDG PET and I-131 scan was within 6 months. An overall clinical evaluation was performed including cytology, thyroglobulin level, sonography, MRI and CT. Metastatic regions were divided into four areas: neck, mediastinum, lung and bone. Among 46 patients, the number of patients, metastatic lesions were detected, totaled 36 (78.3%). Twenty-nine patients (63.0%) were detected by FDG PET and 18 patients (39.1%) were detected by I-131 scan. Twenty-one patients were detected in neck by two methods. Nineteen patients (90.5%) were detected by FDG PET and 7 patients (33.3%) were detected by I-131 scan. Eighteen patients were detected in mediastinum by two methods. Ten patients (55.5%) were detected by FDG PET and 10 patients (55.5%) were detected by I-131 scan. Ten patients were detected in lung by two methods. Nine patients (90.0%) were detected by FDG PET and 3 patients (30.0%) were detected by I-131 scan. Three patients were detected in bone by two methods. Three patients (100%) were detected by FDG PET and 0 patients (0%) were detected by I-131 scan. These data indicate that for detecting metastatic lesions, F-18 FDG PET and I-131 whole body scan may provide complementary information. Thus, the combination of FDG PET and I-131 scan is the method of choice for detecting suspicious metastatic thyroid cancer after total thyroidectomy

  9. Diagnostic I-131 scintigraphy in patients with differentiated thyroid cancer. No additional value of higher scan dose

    International Nuclear Information System (INIS)

    Phan, T.T.H.; Tol, K.M. van; Links, T.P.; Piers, D.A.; Vries, E.G.E. de; Dullaart, R.P.F.; Jager, P.L.

    2004-01-01

    After initial treatment with total thyroidectomy and radio iodine ablation, most follow-up protocols for patients with differentiated thyroid carcinoma contain cyclic diagnostic I-131 imaging and serum thyroglobulin (Tg) measurements. The applied diagnostic I-131 doses vary between 37 and 370 MBq. The aim of this study was to determine the yield of a diagnostic scan with 370 MBq I-131 in patients with a negative diagnostic scan with 74 MBq I-131. Retrospective evaluation of 158 patients who received a high-dose diagnostic scan with 370 MBq I-131 because of a negative low-dose diagnostic scan with 74 MBq I-131. Special attention was paid to the patients with positive high-dose diagnostic scanning and undetectable serum Tg levels after thyroid hormone withdrawal. In 127 (80%) of patients the 370 MBq I-131 scan was negative, just like the preceding low-dose scan. In 31 (20%) of patients abnormal uptake was present on the 370 MBq diagnostic scan. In 19 of these 31 patients serum Tg was undetectable. In 15/19 the high-dose diagnostic scan proved either false positive or demonstrated clinically irrelevant minor ablation rests. In only four patients (2.5%) did the high-dose diagnostic scans reveal possibly relevant uptake caused by residual differentiated thyroid cancer. In 98% of patients a 370 MBq dose of I-131 for diagnostic whole-body scintigraphy (WBS) had no additional value. The combination of a low-dose diagnostic I-131 scan using only 74 MBq combined with a serum Tg level measurement proved sufficient for correct clinical decision making regarding whether the patient requires additional I-131 therapy. (authors)

  10. Measurement Of I-131 In Air Using A Portable Gamma Spectrometer

    International Nuclear Information System (INIS)

    Bunawas; Dadong Iskandar; Wahyudi; U, Wiwik

    2000-01-01

    Aerosol contamination of I-131, radioactive emitting gamma radiation, can be directly measured by using a portable gamma spectrometer which used GC2020 Canberra HPGe detector. Assuming constant concentration of I-131 in the infinite space of semi spherical, calibration factor, and detection limits determined using standard CH 3 I gas. The results showed that the detection limits for 1 hour counting period was 3.06 Bq/m exp.3 for confidence level of 95% (2σ). Field measurements are conducted on several rooms with uncertainties variation between 0.34 and 60.11% compare with true values. Qualitative discussion of the factors contributing to the uncertainty in the in situ result is included

  11. Terapia através da dança com laringectomizados: relato de experiência Terapia a través de la danza con laringectomizados: relato de experiencia Therapy through dance with laringectomized patients: the description of an experience

    Directory of Open Access Journals (Sweden)

    Ana Carla Peto

    2000-12-01

    Full Text Available O presente relato descreve o primeiro encontro do laringectomizado com a Dança no Grupo de Apoio a Pessoa - Ostomizada ¾ Laringectomizados. Este estudo tem o objetivo de fornecer subsídios sobre a importância terapêutica e educativa da dança. A técnica utilizada foi uma dinâmica de grupo em roda com participação de vinte pacientes. A música e os movimentos corporais foram os recursos empregados para desenvolvermos a Terapia Através da Dança. Os resultados evidenciaram bom envolvimento dos pacientes na dinâmica através das linguagens verbal e não verbal e diminuição do estresse.El presente relato describe el primer contacto del laringectomizado con la danza en el Grupo de Apoyo a la Persona ¾ Ostomizada ¾ Laringectomizado. Este estudio tiene el objetivo de ofrecer información sobre la importancia terapéutica y educativa de la danza. La técnica utilizada fue una dinámica de grupo con participación de veinte pacientes. La música y los movimientos corporales fueron los recursos usados para desenvolver la Terapia a través de la Danza. Los resultados mostraron buena participación de los pacientes en la dinámica a través del lenguaje verbal y no verbal , percibiéndose disminución del estrés.This study describes the first contact of laringectomized people with dance in the Group of Support to Ostomized-Laringectomized Patients. This study aimed at searching for elements about the therapeutic and educative importance of dance to them. The technique utilized was group dynamics with the participation of twenty patients. Music and body movements were resources employed for the development of therapy through dance. Results showed a good involvement of the patients in the dynamics though verbal and non- verbal language as well as a decrease in stress.

  12. Prevalencia de factores de riesgo cardiovascular en una población peruana de pacientes con infección por el virus de inmunodeficiencia humana en terapia antiretroviral de gran actividad

    Directory of Open Access Journals (Sweden)

    Germán Valenzuela Rodriguez

    2007-01-01

    Full Text Available Objetivo: Determinar la prevalencia de los factores de riesgo cardiovascular en una cohorte de pacientes con infección por el VIH que recibían terapia antiretroviral de gran actividad (TARGA. Material y métodos: Llevamos a cabo un estudio prospectivo observacional entre los meses de enero a abril del 2006 en pacientes que acudían a consulta ambulatoria del Hospital Rebagliati-ESSALUD-Perú. Resultados: En 276 pacientes encontramos una prevalencia de factores de riesgo cardiovascular como sigue: hipertensión en 3,26%, diabetes mellitus en 1,81%, dislipidemia en 34,05%, tabaquismo en 3,96%, y obesidad en 4,71%. Solo se encontró niveles mayores de colesterol total y triglicéridos en el grupo que recibía inhibidores de proteasa (p<0,05. El 4,16% de esta población tuvo una puntuación de riesgo cardiovascular elevada de acuerdo a la puntuación de Framinghan. Conclusiones: La prevalencia de factores de riesgo cardiovascular en nuestra cohorte fue baja con excepción de la prevalencia de dislipidemia, encontrándose diferencias estadísticamente significativas en la subpoblación de pacientes que recibían inhibidores de proteasa los cuales tuvieron niveles mayores de colesterol total y triglicéridos.(Rev Med Hered 2007;18:10-14.

  13. I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident

    OpenAIRE

    Brenner, Alina V.; Tronko, Mykola D.; Hatch, Maureen; Bogdanova, Tetyana I.; Oliynik, Valery A.; Lubin, Jay H.; Zablotska, Lydia B.; Tereschenko, Valery P.; McConnell, Robert J.; Zamotaeva, Galina A.; O?Kane, Patrick; Bouville, Andre C.; Chaykovskaya, Ludmila V.; Greenebaum, Ellen; Paster, Ihor P.

    2011-01-01

    Background: Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case?control studies, and studies of prevalent cancers. Objective: To address this limitation, we evaluated the dose?response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study. Methods: The cohort consists of individuals < 18 years of age on 26 April 1986 who ...

  14. A feasibility study of thyroid cancer among patients treated with I-131

    International Nuclear Information System (INIS)

    Anderson, T.W.

    1984-04-01

    This study examined the feasibility of conducting a Canada-wide follow-up study of persons receiving I-131 before 1970, to see if current estimates of induction of thyroid cancer are well founded. It is concluded that such a study is not feasible due to the widespread destruction of old records, and the limited quantity of personal identifying information on those records that do still exist

  15. Radiation protection recommendations for I-131 thyrotoxicosis, thyroid cancer and phaeochromocytoma patients

    International Nuclear Information System (INIS)

    Woodings, S.

    2004-01-01

    Iodine-131 patients pose a radiation risk to their family members, carers and colleagues. Doses from thyrotoxicosis and thyroid cancer patients undergoing standard treatments have been well characterised in the literature. However the resulting precautions cannot be easily adapted to circumstances where the patient has an unusual affliction, or an atypical family or occupational environment. In this study, a model for calculating dose from an I-131 patient is derived from first principles. The model is combined with existing results from the literature to determine a distance weighting factor between patients and family members. This technique reduces the uncertainty in the dose calculations by removing the need to guess the unknown patterns of close contact, a problem common to all previous dose calculation techniques. Data is presented for four unusual I-131 treatments; a child thyroid cancer patient, two thyroid cancer dialysis patients and a phaeochromocytoma patient. The model is used to calculate appropriate periods of restricted contact for these patients. The recommendations provide a useful guide for future unusual I-131 treatments. Copyright (2004) Australasian College of Physical Scientists and Engineers in Medicine

  16. I-131 attraction by thyroid during first hours following its oral administration

    International Nuclear Information System (INIS)

    Franquiz, J.M.; Cardenas, R.; Blanco, J.; Garcia, M.

    1982-01-01

    From radioisotopic investigations used to study thyroid function, that of I-131 attraction results to be one of the most known and used in medical practice. In the authors' laboratory measurement of I-131 activity upon the gland has been for long adopted at 24 hours after administration; however, current needs compel to look for an early time (within the first six hours) for measuring it. In the paper results of I-131 attraction by thyroid in a group with more than 200 patients at 2,4 and 24 hours following its administration are presented in order to assess a 24 hours attraction representativeness by an early attraction. Results demonstrate early attraction is representative of an attraction at 24 hours and with the same diagnostic usefulness. Normal and doubtful ranks for attraction in our medium are determined at 2 and 6 hours, being adopted as proceeding for those cases whose value should be found within doubtful rank, a measurement at 24 hours in order to determine functional condition of the gland. (author)

  17. Chemical Process for Treatment of Tellurium and Chromium Liquid Waste from I-131 Radioisotope Production

    International Nuclear Information System (INIS)

    Zainus-Salimin; Gunandjar; Dedy-Harsono; Hendro; Sugeng-Purnomo; Mohammad-Faruq; Zulfakhri

    2000-01-01

    The I-131 radioisotope is used in nuclear medicine for diagnosis and therapy. The I-131 radioisotope is produced by wet distillation at Bandung Nuclear Research Center and generated about 4,875 Itr of liquid waste containing 2,532.8 ppm of tellurium and 1,451.8 ppm chromium at pH 1. Considering its negative impact to the environment caused by toxic behaviour of tellurium and chromium, it is necessary to treat chemically that's liquid waste. The research of chemical treatment of tellurium and chromium liquid waste from I-131 radioisotope production has been done. The steps of process are involved of neutralisation with NaOH, coagulation-flocculation process for step I using Ca(OH) 2 coagulant for precipitation of sulphate, sulphite, oxalic, chrome Cr 3+ , and coagulation-flocculation process for step II using BaCI 2 coagulant for precipitation of chrome Cr 6+ and tellurium from the supernatant of coagulation in step I. The best result of experiment was achieved at 0.0161 ppm of chromium concentration on the supernatant from coagulation-flocculation of step I using 3.5 g Ca(OH) 2 for 100 ml of liquid waste, and 0.95 ppm of tellurium concentration on the final supernatant from coagulation-flocculation by of step II using 0.7 g BaCI 2 for supernatant from coagulation of step I. (author)

  18. Study of the therapeutic dose and the clinical effect on Graves' disease with I-131 treatment

    International Nuclear Information System (INIS)

    Dang, Y.

    2005-01-01

    Full text: Graves' disease is being treated with I-131 for more than 40 years in China. Previously the dose of I-131 used to be calculated using the 'Quimby' formula. We have now observed that the dose of I-131 administered to patients is now lower in recent years than the early years. The radioactive iodine uptake by the thyroid gland has also changed significantly over a period of time. In this paper we intend to explore these reasons and to research the relationship between the dose and the effect as well as the main cause of the incidence of the hypothyroidism. The parameters in 'Quimby' formula including I-131 uptake, effective half-life and thyroid weight were analyzed and compared with each year data from 1961 to 1988 and subjected to multiple regression analysis to determine the influence on the calculation of dose in 4465 patients. The therapeutic effects were compared with the data of the clinical follow-up of patients between 1961-1973 and 1978-1988 in 748 patients. The factors which might lead to the hypothyroidism were investigated with the non-condition logistic regression. The I-131 uptake was repeatedly measured within one week in 100 patients to identify the changing pattern of the I-131 uptake and its influence on the administered therapeutic dose. We observed an increase in the value of I-131 uptake. The value of I-131 uptake showed an increase after 1977, as well as a prolongation of effective half-life after 1973. The main reason for these changes being a replacement of the equipment in 1977 (G-M counter tube was replaced by scintillation counter), and the other reason being salt iodization in China in 1973. These two factors resulted in a significant reduction in the administered dose of I-131 during the period 1974-1988 as compared to the previous period 1961-1973; the mean administered doses being 168.35MBq and 330.33MBq respectively. The result of multiple regression analyses suggested that the thyroid weight and the effective half

  19. Recurrence of pheochromocytoma in 11 years old school child, diagnosed by I-131 MIBG

    International Nuclear Information System (INIS)

    Jara Yorg, J. A; Arias, Cohl; Gimenez, J; Rodriguez, E; Ortiz, L; Mendieta, B; Ayala, R. M; Rodriguez, C; Delgadillo, J. L

    2000-01-01

    Pheocromocytoma is a paraganglioma with an incidence of arterial hypertension approximately of 1%,but its diagnosis has several important issues from the clinical point of view. 1-The tumor resection frequently cure the hypertension. 2.-Its manifestations might simulates other diseases like carcinoid Sx, hypertiroidism,etc. 3.-It is a familiar disease transmitted by an autosomic dominant way. It is 10% bilateral,10%extraadrenal,10% occur in children and 10% are malignant. We present a case of pheochromocytoma recurrency in a young girl,11 y.o. operated 8 months before, at the Clinical Hospital, National University of Paraguay, School of Medicine for a right suprarenal gland pheochromocytoma of 2cms of diameter, who consults the Pediatric Department for arterial hypertension and cefalea. She also had a Von Hippel Sx and Glaucoma. Nuclear Medicine is a non invasive method that use the I-131 Methayodobencylguanidine(MIBG-I-131) with high accuracy to diagnose and treat both neuroblastoma and pheochromocytoma I-131 MIBG is the gold standard for the diagnosis of both entities with a sensitivity between 94-100%6-7 and specificity of 100% being the best method to evaluate these diseases in the pre and post operatory (Au)

  20. The influence of I-131 therapy on FDG uptake in differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Hung Guanguei; Lee Kwowhei; Liao Peiyung; Yang Liheng; Yang Kwangtao

    2008-01-01

    18F-fluorodeoxyglucose positron emission tomography (FDG-PET) [or PET/computed tomography (CT)] is more likely to show false-negative results when it is performed shortly after chemotherapy and/or radiotherapy because of ''metabolic stunning''. The present study aimed to evaluate the influence of I-131 therapy on FDG uptake and the detection of recurrence or metastasis of differentiated thyroid cancer (DTC). We retrospectively enrolled 16 consecutive FDG-PET/CT studies which had been performed in patients with DTC with elevated thyroglobulin (TG) but negative I-131 whole-body scan. All studies were performed under L-thyroxine suppression. The patients were divided into groups A and B for PET/CT performed within 4 months of I-131 therapy or no such therapy, respectively. Each lesion identified on PET/CT was characterized using a 5-point scale by visual analysis: 0=definitely benign, 1=probably benign, 2=equivocal, 3=probably malignant, and 4=definitely malignant. The maximum standardized uptake value (SUV max ) in each lesion was also measured for semiquantitative analysis. We compared the visual grading and SUV max of the lesion of highest FDG uptake between groups A and B. For visual analysis, group B had significantly more patients with an uptake score of 3 or 4 than group A (80% vs. 17%, P=0.01). In addition, there were significantly more equivocal results from group A than from group B (67% vs. 10%, P=0.02). If the patients with the highest uptake scores of 2, 3, and 4 were considered to be positive for local recurrence or metastasis, there would be no significant difference between the positive rates of groups A and B (83% vs. 90%, P=0.7). However, the mean SUV max of positive results was significantly lower for group A than for group B (3.1±0.9 and 6.6±3.5 respectively, P=0.02). The preliminary results suggested that FDG uptake in DTC may be negatively influenced by I-131 therapy within 4 months, resulting in lower FDG uptake and more equivocal results

  1. Radiation exposure to nuclear medicine technologists from administering I-131 therapy dosages

    International Nuclear Information System (INIS)

    Chaudakshetrin, P.; Pusuwan, P.; Sritongkul, N.; Tuntawiroon, M.

    2007-01-01

    Full text: Therapeutic doses of I-131 for treatment of thyroid cancer are administered orally in liquid or capsule form. During the last few years, a total number of patients loaded in our isolation ward increased from 4 to 10 patients per week. When considering radiation safety precautions for attending technologists, it is preferable to use the dose in capsules. The purpose of this study is to compare radiation exposure to nuclear medicine technologists from administering I-131 therapy dosages in capsules and in liquid form in a closed system. Materials and Methods: Three year radiation exposure to technologists during I-131 administration was analyzed. From January 2004 to June 2005 dose administration was in liquid form (n=263) and from July 2005 to February 2007 in capsules (n=541). Radiation dose assessment was performed with an electronic personal dosimeter (PDM 112). The dose rate in μSv and time spent per patient were recorded. Results: Dose received per patient when I-131 was given in a liquid was 3.50 ± 1.67 μSv and 1.17 ± 0.66 μSv when given in capsules. Compared with the use of a liquid, capsules significantly reduced radiation dose to technologists by 66% (P < 0.001). These doses received depended not only on the administered activity but also on the time, distance and shielding. Time spent per patient, including a brief visit before the time of dosing to explain the procedure and answer questions was reduced slightly from 4.4 ± 2.2 to 3.7 ± 1.8 minutes (P < 0.01). These correspond to a reduction in a yearly dose to 1 technologist by 40%, from 0.63 mSv to 0.38 mSv from dosing to 175 and 325 patients respectively. Conclusions: The measured doses clearly showed that handling of I-131 therapy dosages either in a liquid form or capsules are not the major contributors to the technologist's radiation exposure in routine clinical practice. However, one has to be cautious and follow good work practice to avoid risk of radiation exposure and radioiodine

  2. Thyroid uptake of I-131 during anti-thyroid drug treatment

    International Nuclear Information System (INIS)

    Hoque, M.; Alam, F.; Haque, F.S.; Karim, M.A.; Fariduddin, M.

    2004-01-01

    Hyperthyroidism is a global ailment and its treatment is very promising either by ant-thyroid drug or by radioiodine. Iodine-131 uptake test is very important for evaluation of hyperthyroid in respect to its therapy and to exclude thyroiditis. This study was performed to observe the thyroid uptake pattern during intake of anti-thyroid medicine and workout the possibility to start I-131 therapy just after withdraw of antithyroid drug without waiting few days. In this study total 252 patient's I-131 uptake test is performed. Among the patient 135 (53.57%) were female, 117 (64.43%) were male. All this patients were hyperthyroid both clinically and biochemically. Thyroid uptake was taken to all patients at 24 hours after oral administration of 5 to 10 micro-curie of I -131. Uptake was taken by an uptake system and recorded as percentage uptake. These patients are grouped into three categories. Group-A-newly diagnosed cases, who have not taken antithyroid drug or I-131 therapy, there were 82 patients in this group, and their mean uptake was 37.12 ±18.5%. Group B - this group of patients were studied during intake of antithyroid medicine, there were 130 patients in this group and their mean uptake was 34.34±16.0%. Group-B patients were further divided in two sub-groups, patients having antithyroid drug for 1 to 3 weeks (group-B 1), group B1 have mean uptake 37±21% and those were taking antithyroid for 3 weeks to 2 years (group-B2), group B2 have uptake 34.34±20%. Group C- these patients are taken from those patients who had withdrawn antithyroid drug for 3 days to 3 months, there were 40 such patients. Group C further divided into two sub-group, group-C1 (stopped for 3-10 days) and group C2 (stopped for 11 days to 3 months). Group C1 had mean uptake 38±16% and group C2 had mean uptake 35±19%. From this study it is observed that Iodine-131 uptake percentage of untreated hyperthyroid; during antithyroid drug treatment and after withdraw of antithyroid drug almost

  3. Radioimmunotherapy of Nude Mice Bearing Human Colon Carcinoma with I-131 Labeled Anti-carcinoembryonic Antigen

    International Nuclear Information System (INIS)

    Kim, Byung Tae; Lee, Kyung Han; Kim, Sang Eun; Choi, Yong; Chi, Dae Yoon; Chung, June Key; Lee, Myung Chul; Koh, Chang Soon; Chung, Hong Keun

    1995-01-01

    This study was designed to evaluate the effects of various factors on the therapeutic effect of the I-l3l labeled anti-carcinoembryonic antigen monoclonal antibody(anti-CEA antibody). Tetrazolium-based colorimetric assay (MTT) was used to compare in vitro cytotoxicity of 3 Korean colon cancer cell lines (SNU-C2A, SNU-C4, SNU-C5) for selection of proper 2 cell lines in this study. The changes of the size of tumor which was xenografted to nude mice (balb/c nu/nu) were compared in 4 groups (group treated I-131 labeled anti-CEA antibody, group treated with non-radiolabeled anti-CEA antibody, group treated with I-131. labeled anti-human chorionic gonadotropin monoclonal antibody (anti-hCG antibody) as nonspecific antibody, and group injected with normal saline as a control). Immunohistochemical staining and in vivo autoradiography were performed after excision of the xenografted tumor. The results were as below mentioned. The in vitro cytotoxic effect of I-131 labeled anti-CEA antibody is most prominent in SNU-C5 cell line between 3 cancer cell lines. The changes of xenografted tumor size in both SNU-C4 and SNU-C5 cell tumors at the thirteenth day after injection of the antibodies were smallest in the group treated with I-131 labeled anti-CEA antibody (SNU-C4/SNU-C5; 324/342%) comparing with other groups, group treated with anti-CEA antibody (622/660%), group treated with I-131 anti-hCG antibody (538/546%), and control group(1030/724%) (p<0.02 in SNU-C4 and p<0.1in SNU-C5 at the 13th day after injection of antibodies). On the thirteenth day after injection of the antibodies nude mice were sacreficed to count the radiouptake of tumor and to check the changes of tumor size. Correlations between radiouptake and change of tumor size were calculated in each groups and significant negative correlation was only obtained in the group treated with I-131 anti-CEA antibody (p<0.05). There were no correlations between antigenic expression of carcinoembryonic antigen and

  4. Terapia de resincronización con implante de electrodo ventricular izquierdo por vía epicárdica Resynchronization therapy with left ventricular electrode implant via epicardium

    Directory of Open Access Journals (Sweden)

    Francisco Gómez

    2007-12-01

    Full Text Available Introducción: la terapia de resincronización cardiaca es segura y efectiva para mejorar la clase funcional y la calidad de vida, y reducir la mortalidad en pacientes con falla cardiaca en estado funcional III y IV con terapia médica óptima. Métodos: este es el reporte del procedimiento realizado a un grupo de pacientes a quienes se les implantó un marcapasos tricameral para resincronización cardiaca, con inserción del electrodo ventricular izquierdo por vía epicárdica, realizado en la Unidad Cardiovascular y de Trasplantes del Hospital Universitario San Vicente de Paúl y la Universidad de Antioquia, en noviembre de 2004 a febrero de 2006. Los pacientes elegidos para la inserción cumplían con los criterios de falla cardiaca estadio C o D, según la clasificación de la NYHA III ó IV, corroborado con prueba funcional menor de 5 MET, fracción de eyección menor del 35%, QRS mayor de 120 milisegundos y criterios ecocardiográficos de disincronía intraventricular, interventricular o aurículo-ventricular. Resultados: se incluyeron nueve pacientes: cinco hombres y cuatro mujeres, con edad promedio de 57 años; ocho pacientes tenían bloqueo de rama izquierda del haz de His. El procedimiento de implante se realizó en dos tiempos, el primero en la sala de hemodinámica donde se ubicó el electrodo de aurícula derecha y ventrículo derecho, y el segundo en el quirófano, donde se puso un electrodo del ventrículo izquierdo por vía epicárdica por minitoracotomía anterior izquierda. El tiempo total del procedimiento osciló entre 35 a 210 minutos con un promedio de 105 minutos, menor en los últimos pacientes. Las medidas intraoperatorias demuestran un umbral de estimulación promedio de 0,9 mv; la duración del QRS fue menor a 130 milisegundos luego de la estimulación biventricular en el 100% de los casos y el tiempo de detección al estimular con el electrodo ventricular izquierdo, fue mayor de 100 milisegundos en el 100% de los

  5. The physico-chemical I-131 species in the exhaust air of a boiling water reactor (BWR 5)

    International Nuclear Information System (INIS)

    Deuber, H.

    1984-02-01

    In a German boiling water reactor, the pysico-chemical I-131 species were determined in the plant exhaust and in the individual exhausts during four months. These measurements aimed in particular at determining the percentage and the source of the radiologically decisive elemental I-131 released to the environment. On an average 13% of the I-131 discharged with the plant exhaust consisted of elemental iodine. This was largely released with the exhausts from the reactor building and from the turbine building. The main component was organic-bound I. (orig./HP) [de

  6. Influencia de la terapia periodontal no quirúrgica en nivel de pH salival y líquido crevicular gingival en pacientes con enfermedad periodontal atendidos en la Clínica Especializada de la FO-USMP

    OpenAIRE

    Villaverde Moscol, Lizeth Rosario

    2016-01-01

    Determina la influencia de la terapia periodontal no quirúrgica en el nivel de pH salival y el pH líquido crevicular gingival en los pacientes con enfermedad periodontal atendidos en la Clínica Especializada de FO-USMP. La muestra fue conformada por 64 pacientes. Se utilizó tiras reactivas para la recolección del pH salival y pH del líquido crevicular gingival antes y después (07 días) de realizado el terapia periodontal no quirúgica en los pacientes diagnosticados con dos de los tipos de enf...

  7. Cost of antimicrobial treatment in patients infected with multidrug-resistant organisms in the Intensive Care Unit Costo de la terapia antimicrobiana en pacientes infectados con microorganismos multirresistentes en la Unidad de Cuidados Intensivos

    Directory of Open Access Journals (Sweden)

    Fabiana Xavier Cartaxo Salgado

    2011-12-01

    con estos microorganismos puede comprometer la efectividad de la terapia antimicrobiana en estas Unidades y Centros de Salud.

  8. Terapia de choque

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    No hay alternativa, nos dicen. Ya no hay líneas rojas. Sólo un poco más de terapia de choque para aumentar el desorden bipolar entre los que tienen y los que no.......No hay alternativa, nos dicen. Ya no hay líneas rojas. Sólo un poco más de terapia de choque para aumentar el desorden bipolar entre los que tienen y los que no....

  9. ARTE TERAPIA: HERRAMIENTA DE AYUDA EN LA ESCUELA

    OpenAIRE

    Alcázar Ruiz de Peralta, Karla Katherin

    2017-01-01

    La investigación tiene como Objetivo: incluir el arte terapia en la escuela, permitiendo que el docente de arte logre conocer el proceso de arte terapia de manera detallada, saber sus fundamentos, entender sus beneficios y ventajas, con la finalidad de poder aplicarla en el futuro como una herramienta de ayuda en la escuela. Método: la investigación es de diseño no experimental, de tipo descriptivo-analítico. Enfoque cualitativo. Conclusión: el Arte terapia, por ser un proceso adecuado para t...

  10. Utilidad clínica de la terapia metacognitiva en pacientes con trastorno obsesivo compulsivo: un diseño de caso único con replicación directa Clinical utility of metacognitive therapy for obsessive compulsive disorder patients: a single case design with direct replication

    Directory of Open Access Journals (Sweden)

    Ricardo Rodríguez Biglieri

    2006-12-01

    Full Text Available El artículo presenta los resultados preliminares de una investigación tendiente a evaluar la utilidad clínica de dos vertientes de terapia cognitiva en pacientes con Trastorno obsesivo compulsivo (TOC. Una terapia metacognitiva fue aplicada a dos pacientes con TOC en comorbilidad con Trastorno Depresivo Mayor (TDM. Se utilizó un diseño de caso único (A-B con replicación directa entre sujetos. Los resultados son parciales ya que no se contaba todavía con datos de seguimiento. No obstante, los mismos muestran una mejoría significativa en la sintomatología obsesiva y depresiva tras la aplicación del tratamiento, así como un cambio significativo en las creencias relacionadas con el TOC. Al final del período de tratamiento los pacientes no cumplían criterios diagnósticos para TOC ni TDM; además, habían registrado una mejoría en la calidad de vida relacionada con aspectos emocionales. Se discuten las implicaciones teóricas y prácticas de los resultados y se sugieren nuevas líneas de investigación.The article presents preliminary outcomes from an investigation aimed to evaluate the clinical utility of two kinds of cognitive therapy in Obsesive Compulsive Disorder (OCD patients. Metacognitive therapy was applied to two OCD comorbid with Major Depression (MD patients. A single case design (A-B between subjetst with direct replication was used.The findings are limited since we have not follow-up data yet. Nevertheless, outcomes show a significant improvement in obsessive and depressive sympthomatology after the treatment application, as well as a significant change in OCD related beliefs. At the end point of treatment patients no longer met OCD or MD diagnostic criteria. Besides, patients shows an improvement in emotional related aspects of they quality of life.Theoretical and practical implications are discussed, as well as further investigation lines are suggested.

  11. Control system of liquid effluents generated in treatment with I-131

    International Nuclear Information System (INIS)

    Garcia M, T.; Ruiz C, M. A.; Angeles C, A.; Ramirez S, R.

    2015-09-01

    In recent years, nuclear medicine has developed greatly in our country and around the world. Techniques for both medical diagnosis and therapy have increased the use of radiopharmaceuticals, notably the I-131. In Mexico there are around 150 nuclear medicine establishments authorized by the Comision Nacional de Seguridad Nuclear y Salvaguardias. Most of these establishments do not have an appropriate facility for the treatment of radioactive liquid effluents, to ensure compliance with the concentration limits established in the regulations. The Instituto Nacional de Investigaciones Nucleares (ININ) developed and implemented successfully, a control system of radioactive effluents (named SACEL) from a nuclear medicine facility. This system ensures an effective compliance with regulations and also better management and control of these radioactive effluents. Calculations and design of SACEL were made with respect to I-131, because is one of the most commonly used in radiotherapy and medical diagnostics, besides its half-life is greater in relation to other radionuclides. SACEL is comprised of four storage tanks and decay and a fifth tank for measuring the concentration of I-131 and later discharge to the drain; these tanks are connected to an automated system that controls the effluents passage. The calculation to determine the volume of the tanks was carried out according to the demand that has the hospital, to the maximum activity being poured in effluents and time required to decay. In this paper the design and installation of SACEL system, in addition to functioning as a facility that enables the Hospital meet the required standards is presented. Dose calculations performed with MCNPX and the methodology used in the calibration of the detection system is also presented. (Author)

  12. Qualidade de vida de pacientes com câncer colorretal em terapia adjuvante Calidad de vida de pacientes con cáncer de rectocolon en terapia adyuvante Quality of life of patients with colorectal cancer who were receiving complementary therapy

    Directory of Open Access Journals (Sweden)

    Adriana Cristina Nicolussi

    2009-01-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida, identificar os domínios afetados nos pacientes com câncer colorretal, caracterizar os dados sócio-demográficos, clínicos e terapêuticos e correlacioná-los aos domínios da qualidade de vida. MÉTODOS: Estudo transversal, realizado no Centro Especializado de Oncologia de Ribeirão Preto com 22 pacientes com câncer colorretal em terapia adjuvante, entre julho/ 2006 a setembro/ 2007. Utilizou-se o instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: A qualidade de vida foi considerada satisfatória (média = 79,13. Os domínios mais afetados foram: Função Emocional e sintomas dor, insônia, fadiga. Nas correlações, as mulheres destacaram-se negativamente, apresentando piores escores nas Funções Emocional, Cognitiva e sintomas: dor, insônia, fadiga, constipação e perda de apetite. Os pacientes em radioterapia relataram mais dor e os assintomáticos à quimioterapia são os que obtiveram melhor qualidade de vida geral. CONCLUSÃO: A qualidade de vida foi satisfatória, relativamente pior nas mulheres, em radioterapia e que apresentaram efeitos colaterais da quimioterapia.OBJETIVO: Evaluar la calidad de vida, identificar los dominios afectados en los pacientes con cáncer de rectocolon, caracterizar los datos socio-demográficos, clínicos y terapéuticos y correlacionarlos a los dominios de la calidad de vida. MÉTODOS: Estudio transversal, realizado en el Centro Especializado de Oncología de Ribeirão Preto con 22 pacientes con cáncer de rectocolon en terapia adyuvante, entre julio/ 2006 a setiembre/ 2007. Se utilizó el instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: La calidad de vida fue considerada satisfactoria (media = 79,13. Los dominios más afectados fueron: Función Emocional y síntomas dolor, insomnio, fatiga. En las correlaciones, las mujeres se destacaron negativamente, presentando peores escores en las Funciones Emocional, Cognitiva y síntomas: dolor

  13. Dosimetry study of [I-131] and [I-125]- meta-iodobenz guanidine in a simulating model for neuroblastoma metastasis.

    Science.gov (United States)

    Roa, W H; Yaremko, B; McEwan, A; Amanie, J; Yee, D; Cho, J; McQuarrie, S; Riauka, T; Sloboda, R; Wiebe, L; Loebenberg, R; Janicki, C

    2013-02-01

    The physical properties of I-131 may be suboptimal for the delivery of therapeutic radiation to bone marrow metastases, which are common in the natural history of neuroblastoma. In vitro and preliminary clinical studies have implied improved efficacy of I-125 relative to I-131 in certain clinical situations, although areas of uncertainty remain regarding intratumoral dosimetry. This prompted our study using human neuroblastoma multicellular spheroids as a model of metastasis. 3D dose calculations were made using voxel-based Medical Internal Radiation Dosimetry (MIRD) and dose-point-kernel (DPK) techniques. Dose distributions for I-131 and I-125 labeled mIBG were calculated for spheroids (metastases) of various sizes from 0.01 cm to 3 cm diameter, and the relative dose delivered to the tumors was compared for the same limiting dose to the bone marrow. Based on the same data, arguments were advanced based upon the principles of tumor control probability (TCP) to emphasize the potential theoretical utility of I-125 over I-131 in specific clinical situations. I-125-mIBG can deliver a higher and more uniform dose to tumors compared to I-131 mIBG without increasing the dose to the bone marrow. Depending on the tumor size and biological half-life, the relative dose to tumors of less than 1 mm diameter can increase several-fold. TCP calculations indicate that tumor control increases with increasing administered activity, and that I-125 is more effective than I-131 for tumor diameters of 0.01 cm or less. This study suggests that I-125-mIBG is dosimetrically superior to I-131-mIBG therapy for small bone marrow metastases from neuroblastoma. It is logical to consider adding I-125-mIBG to I-131-mIBG in multi-modality therapy as these two isotopes could be complementary in terms of their cumulative dosimetry.

  14. A preliminary study of radioimmunoimaging of ovarian malignancy with I-131 labelled CEA monoclonal antibody

    International Nuclear Information System (INIS)

    Hu Likuan

    1988-01-01

    Ten cases of ovarian cancers have been detected with I-131 labelled CEA McAb and computer assisted clual radionuclide subtraction technique. The lesions (both primary and secondary) are clearly visualized and proved by surgical and pathohistological findings. 30 of 31 metastatic lesions are localized with a positive rate 97%. It seems to be a sensitive and specific procedure for early diagnosis of ovarian cancer so far. It is also valuable for staging clinical course and making decision on treatment, assessing the prognosis of ovarian cancer as well

  15. Myocardial distribution of I131-labeled hexadecenoic acid in relation to the dog local coronary flow

    International Nuclear Information System (INIS)

    Riche, F.; Busquet, G.; Pilichowski, P.; Wolf, J.E.; Mathieu, J.P.; Comet, M.; Pernin, C.; Vidal, M.; Vincens, M.; Godart, J.

    1981-01-01

    20 anesthetized and thoracotomized dogs are studied. The local myocardial blood flow is measured with sup(99m)Tc human albumin microspheres. The intramyocardial distribution of the 16-I(131)-9-hexadecenoic acid in relation to local blood flow is studied in basal conditions (7 dogs), after experimental infarction (6 dogs) and postischemic reactive hyperhemia (7 dogs). We conclude that during basal condition, after infarction but not during reactive hyperhemia, the distribution of the labeled fatty acid reflect the local variations of blood flow [fr

  16. Septal penetration correction in I-131 imaging following thyroid cancer treatment

    Science.gov (United States)

    Barrack, Fiona; Scuffham, James; McQuaid, Sarah

    2018-04-01

    Whole body gamma camera images acquired after I-131 treatment for thyroid cancer can suffer from collimator septal penetration artefacts because of the high energy of the gamma photons. This results in the appearance of ‘spoke’ artefacts, emanating from regions of high activity concentration, caused by the non-isotropic attenuation of the collimator. Deconvolution has the potential to reduce such artefacts, by taking into account the non-Gaussian point-spread-function (PSF) of the system. A Richardson–Lucy deconvolution algorithm, with and without prior scatter-correction was tested as a method of reducing septal penetration in planar gamma camera images. Phantom images (hot spheres within a warm background) were acquired and deconvolution using a measured PSF was applied. The results were evaluated through region-of-interest and line profile analysis to determine the success of artefact reduction and the optimal number of deconvolution iterations and damping parameter (λ). Without scatter-correction, the optimal results were obtained with 15 iterations and λ  =  0.01, with the counts in the spokes reduced to 20% of the original value, indicating a substantial decrease in their prominence. When a triple-energy-window scatter-correction was applied prior to deconvolution, the optimal results were obtained with six iterations and λ  =  0.02, which reduced the spoke counts to 3% of the original value. The prior application of scatter-correction therefore produced the best results, with a marked change in the appearance of the images. The optimal settings were then applied to six patient datasets, to demonstrate its utility in the clinical setting. In all datasets, spoke artefacts were substantially reduced after the application of scatter-correction and deconvolution, with the mean spoke count being reduced to 10% of the original value. This indicates that deconvolution is a promising technique for septal penetration artefact reduction that

  17. Terapia nutricional nas alterações metabólicas em pessoas vivendo com HIV/aids Terapia nutricional en las alteraciones metabólicas en personas viviendo con VIH/Sida Nutritional therapy in metabolic changes in individuals with HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Marianne Falco

    2012-08-01

    las alteraciones metabólicas provocadas por el uso de la terapia antirretroviral en adultos viviendo con VIH/Sida. MÉTODOS: Revisión sistemática de literatura en el PubMed, Lilacs y Cochrane, entre 1996 y 2010, del tipo ensayo clínico, controlado, aleatorio, crossover, adultos, viviendo con VIH/Sida en uso de terapia antirretroviral y sin enfermedades oportunistas. La intervención de interés fue suplementación nutricional vía oral y/o cambio de estilo de vida por tratamiento dietoterápico específico: dislipidemia, resistencia insulínica, lipodistrofia e hipertensión arterial sistémica. Se utilizó la escala de Jadad para clasificación cualitativa de los artículos. RESULTADOS: Se localizaron 385 artículos y siete fueron incluidos. Las intervenciones utilizadas en estos estudios fueron: dieta, dieta más ejercicio físico, dieta más suplemento y solamente suplementos. Dislipidemia fue el resultado evaluado en todos los estudios. Los estudios que evaluaron suplementación con omega 3 encontraron reducción significativa de los triglicéridos. La dieta específica más suplementación de omega 3 mostró aumento de HDL-colesterol. Suplementación con nicotinato de cromo no tuvo efecto sobre la dislipidemia. La modificación de estilo de vida, incluyendo dieta y actividad física, redujo significativamente la circunferencia de la cintura, lipodistrofia y presión arterial sistólica. CONCLUSIONES: La reducción de triglicéridos por la suplementación con omega 3 fue la intervención nutricional con mayores evidencias científicas. La prescripción de dieta específica parece ser la intervención más adecuada para aumentar HDL-colesterol. No es posible hacer inferencias sobre el tratamiento nutricional del colesterol total, LDL-colesterol y resistencia insulínica. Las modificaciones en el estilo de vida pueden promover mejoría de la lipodistrofia y presión arterial.OBJECTIVE: To analyze the effect of nutritional treatment on metabolic changes caused by

  18. Culpa o Responsabilidad: Terapia con Madres de Niñas y Niños que han Sufrido Abuso Sexual Blame or Responsibility: Therapy for Mothers of Girls and Boys who had Suffered Sexual Abuse

    Directory of Open Access Journals (Sweden)

    Caroline Sinclair

    2006-11-01

    Full Text Available Se desarrolla un modelo psicoterapéutico para madres de niñas y niños que sufrieron abuso sexual intrafamiliar, considerando que el apoyo materno es el factor más significativo en la moderación del impacto traumático en los niños. La literatura tradicional se ha centrado en dilucidar el rol de la madre en la génesis del abuso, predominando un enfoque culpabilizador que contribuye a su descalificación como figura protectora post-revelación. Se propone un enfoque de responsabilidad que destaca la importancia de desarrollar intervenciones que, junto con potenciar la activación de sus recursos protectores, permita acoger el impacto traumático de la madre ante el abuso y sus consecuencias. El modelo propuesto considera los objetivos de la terapia con la madre y las fases del proceso.This article explains the development of a psychotherapeutic model for mothers of girls and boys who have undergone intra-familiar sexual abuse. Our model considers that maternal support is the most significant factor minimizing the abused child's traumatic impact. Traditional literature has focused in explaining the mother's role in the origins of sexual abuse with a predominating blame approach, which contributes to her disqualification as a protective figure. Far from a blame approach, our method proposes a responsibility approach highlighting the importance of interventions prompting the activation of the mother's protective resources and allowing them to deal with her traumatic impact when they have to face her child's sexual abuse and its consequences. This model describes both, therapeutic goals with the mother and process stages.

  19. Hacia una terapia neuroprotectora con cannabinoides en la enfermedad de Huntington : estudios preclínicos y clínicos

    OpenAIRE

    Valdeolivas Rojas, Sara

    2017-01-01

    La enfermedad de Huntington (EH) es una enfermedad con herencia autosómica dominante causada por una mutación en el gen IT15, que codifica la proteína huntingtina (HTT). Esta proteína presenta una amplia expresión células de mamíferos y, aunque su función exacta no es totalmente conocida, se sabe que está relacionada con la modulación de procesos celulares tales como transcripción génica, señalización celular, metabolismo energético y neurogénesis. La mutación consiste en una expansión excesi...

  20. Experiência clínica com o uso de sedativos em terapia intensiva: estudo retrospectivo Experiencia clínica con el uso de sedativos en la terapia intensiva: estudio retrospectivo Clinical experience with sedatives in the intensive care unit: a retrospective study

    Directory of Open Access Journals (Sweden)

    Geraldo Rolim Rodrigues Júnior

    2002-11-01

    tiopental sumaron 19,5%. Bloqueadores neuromusculares fueron utilizados en 22,7% de los casos en pacientes ventilados artificialmente. CONCLUSIONES: La sedación es un recurso terapéutico frecuente en la Terapia Intensiva, comúnmente utilizada para facilitar la ventilación artificial y tratar los problemas de naturaleza psiquiátrica. Fentanil, aisladamente o en asociación con midazolam, fue el agente más utilizado.BACKGROUND AND OBJECTIVES: Among the most frequent indications for Intensive Care Unit patients sedation, one may mention artificial ventilation installation and maintenance, anxiety and uncomfortable or painful procedures. This retrospective study aimed at evaluating most common sedation indications and techniques for severe patients admitted to the Surgical Intensive Care Unit, Escola Paulista de Medicina (EPM/UNIFESP during an 11-month period. METHODS: After excluding patients remaining in the ICU for less than 24 hours and those without the necessary evaluation to determine their severity index (APACHE II, the sample was reduced to 307 patients. Most common techniques, sedation indications and neuromuscular blockers association were evaluated. RESULTS: Sedation was administered to 37.4% of patients. Psychiatric disorders, such as delirium, agitation, fear and anxiety, were some indications for sedation and corresponded to 25.77% of all indications. Most ventilated patients also needed sedative agents and mechanical ventilation installation and maintenance represented most indications, or approximately 57.73% of all sedated patients. Procedures, such as tracheal intubation and bronchoscopy, represented 11.34% of all indications and metabolic control (barbiturate coma and tetanus represented 5.15% of the cases. Most common sedative techniques included opioids alone or associated to benzodiazepines. In this study, fentanyl alone was used in 58% of the cases, and fentanyl plus midazolam in 21.64% of patients. Haloperidol, diazepam, propofol and thiopental

  1. Calibration of the Accuscan II In Vivo System for I-131 Thyroid Counting

    Energy Technology Data Exchange (ETDEWEB)

    Orval R. Perry; David L. Georgeson

    2011-07-01

    This report describes the March 2011 calibration of the Accuscan II HpGe In Vivo system for I-131 thyroid counting. The source used for the calibration was an Analytics mixed gamma source 82834-121 distributed in an epoxy matrix in a Wheaton Liquid Scintillation Vial with energies from 88.0 keV to 1836.1 keV. The center of the detectors was position 64-feet from the vault floor. This position places the approximate center line of the detectors at the center line of the source in the thyroid tube. The calibration was performed using an RMC II phantom (Appendix J). Validation testing was performed using a Ba-133 source and an ANSI N44.3 Phantom (Appendix I). This report includes an overview introduction and records for the energy/FWHM and efficiency calibrations including verification counting. The Accuscan II system was successfully calibrated for counting the thyroid for I-131 and verified in accordance with ANSI/HPS N13.30-1996 criteria.

  2. I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.

    Science.gov (United States)

    Brenner, Alina V; Tronko, Mykola D; Hatch, Maureen; Bogdanova, Tetyana I; Oliynik, Valery A; Lubin, Jay H; Zablotska, Lydia B; Tereschenko, Valery P; McConnell, Robert J; Zamotaeva, Galina A; O'Kane, Patrick; Bouville, Andre C; Chaykovskaya, Ludmila V; Greenebaum, Ellen; Paster, Ihor P; Shpak, Victor M; Ron, Elaine

    2011-07-01

    Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case-control studies, and studies of prevalent cancers. To address this limitation, we evaluated the dose-response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study. The cohort consists of individuals radioactivity measurements taken within 2 months after the accident, environmental transport models, and interview data. Excess radiation risks were estimated using Poisson regression models. Sixty-five incident thyroid cancers were diagnosed during the second through fourth screenings and 73,004 person-years (PY) of observation. The dose-response relationship was consistent with linearity on relative and absolute scales, although the excess relative risk (ERR) model described data better than did the excess absolute risk (EAR) model. The ERR per gray was 1.91 [95% confidence interval (CI), 0.43-6.34], and the EAR per 10⁴ PY/Gy was 2.21 (95% CI, 0.04-5.78). The ERR per gray varied significantly by oblast of residence but not by time since exposure, use of iodine prophylaxis, iodine status, sex, age, or tumor size. I-131-related thyroid cancer risks persisted for two decades after exposure, with no evidence of decrease during the observation period. The radiation risks, although smaller, are compatible with those of retrospective and ecological post-Chornobyl studies.

  3. Evaluation for Preparation of I-131-MIBG for Diagnosis and Therapy Neuroblastoma

    International Nuclear Information System (INIS)

    Laksmi Andri A; Purwoko; Sri Setyowati; Maskur; Cahya Nova Ardianto; Adang Hardi G

    2012-01-01

    Evaluation for preparation of 131 I-MIBG have been carried out. Production/preparation of 131 I-MIBG was carried out by labeling MIBG with I-131, the radiochemical purity of 131 I-MIBG was analysed using TLC/paper chromatography. The stability in the human body by using fresh human plasma, at room temperature and at 8°C was carried out. The chemical purity of synthesized MIBG was found to be > 95%, the labeled MIBG with I-131 was analysed using TLC/paper chromatography. The radiochemical purity of 131 I-MIBG was obtained at higher than 95 %. The stability of labeled MIBG in fresh human plasma and at 8°C was stable up to 141 hours, while at room temperature was stable up to 120 hours. The results of labeling of 131 I-MIBG from 2010-2012 showed that these products were colorless clear solution with pH between 5.5.0-7.0, sterile and pyrogen-free, radiochemical purity > 95%. The quality control results were found to be met with the requirements of 131 I-MIBG injection solution used for diagnosis and therapy of neuroblastoma in Hospital. (author)

  4. Post-Irradiation Behaviour of I131 in TeO2

    International Nuclear Information System (INIS)

    Jaćimović, Lj.; Stevović, J.; Veljković, S.R.

    1965-01-01

    The system I 131 in TeO 2 is interesting because little is known about thermal chemical changes in this target. Radioiodine was produced by neutron irradiation of TeO 2 in the reactor. Irradiated TeO 2 was dissolved in diluted NaOH. The analysis of the iodine valency forms was made by ion exchange techniques. The thermal and radiation stability of TeO 2 was studied by using the spectrophotometric method for the determination of tellurium. Post-irradiation annealing of I 131 in TeO 2 was studied in dependence on the time and temperature of the heating. The main tendency of annealing was the reduction of radioiodine. The time dependence of this process indicates a fast change at high temperatures. The curves are more complex at lower temperatures. The annealing may appear complex because of the variety of thermal reactions of iodine intermediary. It may react with products of the following processes: tellurium recoil and corresponding hot zone, beta transition of Te 131 and TeO 2 itself. The kinetics of these changes was considered and an estimation of the processes during annealing was made. The influence of the neutron flux on the kinetics of annealing was also studied. (author) [fr

  5. Effects of changed working methods on personnel doses at a I-131 and afterloading therapy ward

    International Nuclear Information System (INIS)

    Lange, D.; Wolf, G.; Georgi, P.; Bauer, M.

    1985-01-01

    The external load of the personnel from I-131 therapy can be kept small (almost 'neglectable') by appropriate behaviour without keeping patients 'under-lock and key'. The marked decrease in personnel doses is due to improved radiation protection for afterloading therapy (gynecological Ra-therapy, Cs-137-therapy) by technical equipment. This therapy is now possible but with the door of the application room closed; when the door is opened, the instruments automatically go back to their original position. From 1975 through 1982, there were remote control errors forcing the personnel to withdraw the instruments to the safe manually. Despite working regulations the personnel was able to go into the room without prior instrument withdrawal. The personnel doses so received were within the tolerance limits, however markedly above the inevitable values. Because of regular thyroid gland examination of the personnel there is proof for the fact that the radiation load of this organ from I-131 is probably smaller than 2% (6 mSv/a=600 mrem/a) of the annual limit value of 0.3 Sv (30 rem) which corresponds to 6 times the value of normal load. (orig./HP) [de

  6. Methodology for Gamma cameras calibration for I-131 uptake quantification in Hyperthyroidism diseases

    International Nuclear Information System (INIS)

    Lopez Diaz, A.; Palau San Pedro, A.; Martin Escuela, J. M.; Reynosa Montejo, R.; Castillo, J.; Torres Aroche, L.

    2015-01-01

    Optimization and verification of Patient-Specific Treatment Planning with unsealed I-131 sources is a desirable goal from medical and radiation protection point of view. To obtain a practical protocol to combine the estimation of the related parameters with patient's specific treatment dose in hyperthyroidism disease, 3 equipment were studied (Iodine Probe, a Philips Forte Camera with pin-hole collimators and a Mediso Nucline with HEGP for planar and SPECT techniques) and crossed calibrated. The linear behaviour on diagnostic and therapeutic activity range was verified, showing a linear correlation fitting factor R 2 > 0.99. The differences between thyroid uptake determinations in all equipment were less than 6% for therapeutic activities and less than 1.1% in the diagnostic range. The combined protocol to calculate, with only one administration of I 131 , all the necessary parameters to the treatment dose estimation in 2D or 3D, avoiding wasting time with gamma cameras, was established and verified. Following this protocol the difference between apparent and calculated activities were less than 3%. (Author)

  7. Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Brinks, Peter; Van Gils, Koen; Dickerscheid, Dennis B.M.; Habraken, Jan B.A. [Department of Medical Physics, St. Antonius Hospital, Nieuwegein (Netherlands); Kranenborg, Ellen; Lavalaye, Jules [Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein (Netherlands)

    2017-06-15

    Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy. In this feasibility study we used a novel measurement device [Collar Therapy Indicator (CoTI)] to measure the uptake curve of patients undergoing I-131 radioiodine therapy. The CoTI device is a light-weight wearable device that contains two independent gamma radiation detectors that are placed in a collar. By comparing results of thyroid uptake measurements with results obtained with a gamma camera, the precision of the system is demonstrated. Additionally, for three patients the uptake curve is measured during 48 h of admission in the hospital. The presented results demonstrate the feasibility of the new measurement device to measure the uptake curve during radioiodine therapy. (orig.)

  8. Nurses' leadership styles in the icu: association with personal and professional profile and workload Estilos de liderazgo de enfermeros en una unidad de terapia intensiva: asociación con el perfil personal, profesional y con la carga de trabajo Estilos de liderança de enfermeiros em unidade de terapia intensiva: associação com perfil pessoal, profissional e carga de trabalho

    Directory of Open Access Journals (Sweden)

    Alexandre Pazetto Balsanelli

    2009-02-01

    Full Text Available This study aims to explore the association between nurses' leadership styles and personal and professional nursing profile and workload. The sample consisted of seven nurses and seven nursing technicians who were grouped into pairs. At the end of three months, nurses were queried regarding what leadership style would be adopted when the nursing technician under their evaluation delivered care to patients admitted to the ICU. Relevant data was analyzed by applying descriptive statistics, Tukey's multiple comparison test and Student's t-test (p0.05. The determine, persuade, and share leadership styles prevailed. However, whenever the nursing workload peaked, the determine and persuade styles were used (pEste estudio tuvo como objetivos verificar a relación que existe entre los estilos de liderazgo de los enfermeros con el perfil personal, profesional y carga de trabajo de enfermería. La muestra fue constituida por siete enfermeros y siete técnicos de enfermería que formaron parejas. Durante tres meses los enfermeros fueron cuestionados sobre cual sería el estilo de liderazgo adoptado cuando el técnico de enfermería, bajo su evaluación, prestase cuidados a los pacientes admitidos en la Unidad de Terapia Intensiva. Los datos fueron analizados aplicándose estadística descriptiva, el método de comparaciones múltiples de Tukey y la prueba t de Student (0,05. Los estilos de liderazgo: determinar, persuadir y compartir fueron los predominantes, sin embargo, cuando la carga de trabajo de enfermería era mayor, se observaron los estilos determinar y persuadir (pEste estudo teve como objetivos verificar a relação dos estilos de liderança de enfermeiros com perfil pessoal e profissional e carga de trabalho de enfermagem. A amostra foi constituída por sete enfermeiros e sete técnicos de enfermagem que formaram duplas. Durante três meses os enfermeiros foram questionados sobre qual estilo de liderança seria adotado quando o técnico de

  9. SU-F-T-222: Dose of Fetus and Infant Following Accidental Intakes of I-131 by the Mother

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Y [The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan (China); Hu, P [Fudan University Shanghai Cancer Center, Shanghai, Shanghai (China)

    2016-06-15

    Purpose: To estimate the calculation of absorbed dose to the fetus and infants from intakes of I-131 by the mother. Thus provide some advice to the radioprotection of radioactive accident. Methods: In this clinical case, a staff of nuclear medicine accidently intake I-131 during (10–12 weeks) and after pregnancy. The infant was born at full term, but both lobes of the thyroid gland were found to be absent (bilobar thyroid agenesis). It was suspected that the fetal thyroid agenesis may be related with mother’s contamination of I-131 during pregnancy. Urine samples for 24h were collected at different times after administered and radioactivity were measured to calculate the dose of intake I-131. Calculate the intake I-131 by the results of personal TLD dosimeter. We adopted the mean of two calculated results as the I-131 intake. According to the dose of intake I-131 by the mother, effective dose and absorbed dose of thyroid for mother, fetus and infant were calculated. Results: The intake of I-131 was estimated for 8.18 mCi. I-131 intake was calculated for 7.9 mCi based on data of TLD dosimeter. We adopted the mean of two results as the I-131 intake. The final result was 8.0 mCi. Effective dose and absorbed dose of thyroid for mother were 7.3Sv and 164 Gy, effective dose and absorbed dose of thyroid for fetus were 2.035 Sv and 40.7 Gy, effective dose and absorbed dose of thyroid for infant were 16.25 Sv and 355Gy. Conclusion: The intake during pregnancy was about 1mCi. The absorbed dose of thyroid of the mother was 19.5Gy, whereas the effective of infant was estimated for 40.7Gy. The function of the mother’s thyroid was normal after diagnosis. But the infant was diagnosed as bilobar thyroid agenesis.

  10. Status of urinary iodine and I-131 uptake after universal iodination of common salt

    International Nuclear Information System (INIS)

    Alam, F.; Begum, F.; Haque, M.; Karim, M.A.; Faruque, O.; Ali, L.; Khan, A.K.A.

    2002-01-01

    This work was carried out in the Institute of Institute of Nuclear Medicine (INM), Bangabandhu Sheikh Mujib Medical University and Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka. Here we have tried to explore present status of urinary iodine and uptake status in Bangabandhu. Period study was from 1998 to 2000. Total study population was 300, of them 84 was male and 216 was female. Populations of all social and economic strata have been studied, starting from bottoms to top-level income groups as well as urban, rural and suburban populations are included randomly. We studied I-131 uptake and urinary iodine. I-131 given orally in liquid form and the quantity accumulated by the thyroid gland at 24 hours intervals of time is measured using a gamma scintillation counter. Gamma-ray emission of 364 keV energy by I-131 is detected gamma scintillation counter. Urinary iodine is estimated by CIS-BIO kit. Urine is digested with chloric acid under mild conditions and determined manually by its catalytic role in the reduction of ceric ammonium sulfate in the presence of arsenious acid. The uptake was grouped into four categories according to their uptake percentage. Group-A; (lowest uptake group) 99 subject, have uptake between 0 to 4.9%, Group-B; 100 subjects, (relatively low uptake) who have uptake between 4.91-9.9%, group-C; 73 subjects, who have uptake between 10-30% and in-group D, there was 28 subjects their uptake was above 30%. We have also found in group-A median uptake is 3.0% and urinary iodine level is 43.31 μg/dl, in group-B median uptake is 7.0% and urinary iodine level is 33.95 μg/dl, in group-C median uptake is 23.0% and urinary iodine level is 12.97 μg/dl, in group-D median uptake is 34.0% and urinary iodine level is 9.35 μg/dl. We have found 1.04% have severe type low urinary iodine, 3.48% moderate type of low urinary iodine, 3.48%, 16.72% mild type of low urinary iodine and 78.74% have normal

  11. Comparison of four different protocols of I-131 therapy for toxic single thyroid nodule

    International Nuclear Information System (INIS)

    Zakavi, S.R.; Mousavi, Z.

    2007-01-01

    Full text: Aim: Radio-iodine therapy is the preferred method of treatment of toxic thyroid nodule, however there is no consensus on the dose of I-131 administered. The aim of this study was to compare 4 different dose protocols for treatment of these patients. Methods and patients: All patients with hyperthyroidism and single hot thyroid nodule were referred for I-131 therapy after thyroid physical examination, ultrasonography and measurements of 24 hours thyroid iodine uptake. They were randomly entered in one of 4 groups: fixed low dose (FLD), fixed high dose (FHD), calculated low dose (CLD) and calculated high dose (CHD). In fixed dose protocol, 13mCi of I-131 was administered for patients in FLD group and 22.5mCi was administered for patients in FHD group. Quimby formula was used for calculation of radio-iodine dose in calculated groups with 90-100uCi and 180-200uCi per gram of thyroid weight in CLD and CHD groups respectively. Patients were followed up for a mean of 2, 5, 10 , 22 and 50 months later and physical exam and measurements of thyroid values were done in each follow up. Results: One hundred and sixteen patients were studied. One 72 year old patient was decreased 2 months after treatment due to coronary artery disease and 18 other patients did not complete follow up. From 97 patients who completed follow- up 8 patients were male and 89 patients were female. Mean age of patients were 43.3 years (SD=13.4) and mean thyroid nodule weight was 51 grams (SD=19.2).Mean 24 hours thyroid uptake was 48.07% (SD=14.07). Follow up was done up to 85 months with a median follow up of 14 months. Twenty two patients were in CHD group, 23 patients in CLD, 25 patients in FLD and 27 patients in FHD group. No significant difference was noted in 4 groups regarding age, sex, thyroid uptake and thyroid weight. The mean administered dose was 10.5mCi (SD=3.2) and 18.7mCi (SD=5.3) in CLD and CHD groups respectively (P<0.001). In CHD group, hyperthyroidism was decreased from 33

  12. Efficacy of adalimumab in patients with crohn's disease and failure to infliximab therapy: a clinical series Eficacia de Adalimumab en pacientes con enfermedad de Crohn y fracaso previo a la terapia con Infliximab: resultados de una serie clínica

    Directory of Open Access Journals (Sweden)

    Patricia Cordero-Ruiz

    2011-06-01

    Full Text Available Background: adalimumab, a human anti-TNF, is an effective induction and maintenance therapy for patients with moderate to severe Crohn's disease. It seems to be effective in patients with resistance to infliximab, too, though the experience is more limited. Aim: to evaluate the efficacy of adalimumab, in patients with Crohn's disease (CD and failure to previous treatment with infliximab. B twenty-five patients with CD and failure to previous treatment with infliximab were enrolled; they were treated with 160/80 (24 patients and 80/40 (1 patient induction doses. We analyze clinical response to treatment with adalimumab by the Crohn's disease Activity Index (CDAI and plasma concentration of C-reactive protein (CRP, steroid sparing and complete fistula closure at week 48. Results: eighteen out of twenty-five patients (72% achieved clinical remission (CDAI score Introducción: adalimumab, un anti-TNF humano, ha demostrado ser efectivo en la inducción y tratamiento de mantenimiento de la enfermedad de Crohn moderada-grave. Existe menos experiencia, pero este fármaco parece también eficaz en los pacientes con pérdida de respuesta o intolerancia al infliximab. Objetivo: evaluar la eficacia de adalimumab durante un año, en nuestra serie de pacientes con enfermedad de Crohn (EC y fracaso en el tratamiento previo con infliximab. Métodos: se incluyen 25 pacientes con enfermedad de Crohn y fracaso previo a la terapia con infliximab, que son tratados con adalimumab. Se utilizaron dosis de inducción de 160/80 mg en 24 pacientes y dosis de 80/40 en un paciente. Analizamos la respuesta clínica al tratamiento con adalimumab mediante el Índice de actividad de la enfermedad de Crohn (CDAI y las concentraciones plasmáticas de proteína C reactiva (PCR, el cese de la corticoterapia y el cierre completo de las fistulas en la semana 48. Resultados: dieciocho de veinticinco pacientes (72% alcanzan la remisión clínica (CDAI < 150 en la semana 24 y 15

  13. Internal Dosimetry Of I-131 For Radiation Workers Based On Analysis Of The Human Urine And Liquid Scintillation Counting

    International Nuclear Information System (INIS)

    Nguyen Van Hung; Pham Hung Thai; Le Van Ngoc

    2011-01-01

    Internal dosimetry of I-131 for radiation workers based on analysis of the human urine, measuring radioactivity by the liquid scintillation system, and dose calculation by the specialized code has been firstly studied at the Nuclear Research Institute. Urine samples from the subjects internally contaminated with I-131 through respiratory ways were collected, chemically processed, measured beta radioactivities of I-131 by the liquid scintillation system of ALOKA-LSC-6100, and then thyroid doses and effective ones for whole-body were calculated by using the specialized code of LUDEP 2.0. Based on chemically separation procedure for I-131 in urine samples and the low background HPGe gamma spectrometer of Canberra for measuring radioactivity, efficiency for chemical separation was determined to be (86.1 ± 5.0)%. The experimental results for 9 subjects with urine samples to be collected during 4 operating courses of Dalat nuclear reactor with production of I-131 (from June to September, 2010) were shown that thyroid doses and effective ones for whole-body for each course of I-131 production were in ranges of from 0.11 to 13.00 mSv and from 0.01 to 0.71 mSv, respectively. Therefore, totally average doses per year for thyroid and whole-body were less than the correlative levels of permissible doses. Besides, the liquid scintillation method was also compared experimentally with the gamma spectrometry (measuring directly urine samples by the gamma spectrometer to be carried out at the Institute before) was shown that errors on dosimetric results between them were less than 12%. This was proved the dosimetry has had a confidence, and it could be applied for internal dosimetry for radiation workers contacting with unsealed sources of I-131 in radiation installations as well as for diagnostic and therapeutic patients in health ones. (author)

  14. Hipnosis y terapias cognitivas

    OpenAIRE

    Feixas i Viaplana, Guillem

    2008-01-01

    La hipnosis y la terapia cognitiva parecen reflejar, en principio, dos concepciones muy distintas de la intervención psicológica. Sin embargo, ambas contemplan entre sus objetivos la reorganización de las estructuras cognitivas del cliente. Este objetivo común las hace compatibles y podría permitir a las terapias cognitivas nuevas formas de intervenir en tales estructuras. La hipnosis promueve que el cliente haga por sí mismo este proceso de reestructuración sin el control racional y conscien...

  15. Alteraciones metabólicas con terapia antirretroviral altamente efectiva en niños positivos para VIH, Cali, Colombia Metabolic alterations with anti-retroviral highly effective therapy in positive children for VIH, Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Pío López

    2009-12-01

    Full Text Available Objetivos: describir las alteraciones metabólicas en niños con diagnóstico de VIH y en tratamiento con terapia antirretroviral altamente efectiva (Highly Active Antiretroviral Therapy, HAART. Métodos: se realizó una primera fase descriptiva de los valores de lípidos y glucemia en una cohorte de niños positivos para VIH. De una clínica pediátrica se reclutaron, entre junio de 2003 y junio de 2005, niños mayores de un mes y menores de 16 años en terapia HAART. Estos resultados se compararon con valores de la población. En una segunda fase, se estudió la densidad ósea en estos niños, utilizando DEXA (dual energy X-ray absorptiometry y antropometría, y se comparó la de controles sanos. Resultados: se incluyeron 38 niños positivos para VIH. En 59,5% de los niños se clasificaron con displidemia. Al compararlo con la población de referencia, el grupo positivo para VIH presentó una prevalencia mayor de hipertrigliceridemia y HDLc (highdensity lipoprotein anormalmente bajo. Tomando en cuenta la variación por edad, los valores de colesterol total y LDLc (lowdensity lipoprotein, mostraron un aumento en el grupo que recibía inhibidores de proteasa (IP contra el que no. La diferencia del puntaje Z de BMD (bone mineral density entre los grupos fue de 0,56 (IC95%: 0,1- 1,0, teniendo un menor puntaje Z el grupo positivo para VIH. El puntaje Z de la densidad de masa ósea mostró un declive con el tiempo de exposición, que no fue evidente en el grupo control. Conclusiones: encontramos alteraciones en los lípidos similares a las descritas en el adulto seropositivo. En el grupo con IP se encontraron alteraciones del colesterol que cambiaban según la edad. Se encontró una pérdida de la densidad ósea, progresiva con el tiempo de exposición e independiente de la edad. Consideramos que esta relación podría ser de origen multifactorial, incluyendo los efectos de la infección y del tratamiento.Objectives: our goal is to describe

  16. Preliminary evaluation of maggot (Diptera: Calliphoridae therapy as a potential treatment for leishmaniasis ulcers Evaluación preliminar en un modelo animal de la terapia con larvas de Lucilia sericata para el tratamiento de la leishmaniasis cutánea

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    Jazzmin Arrivillaga

    2008-06-01

    Full Text Available Introduction. Maggot debridement therapy has been widely used for treating a variety of scarred-over soft-tissue wounds. Published accounts record several illnesses in which treatment with larval therapy has promoted injury healing in conjunction with infection by bacterial pathogens resistant to conventional antibiotics.
    Objective. An initial test of the maggot therapy was developed for cutaneous injuries produced by Leishmania amazonensis.
    Materials and methods. An experimental design based on an animal model with three replicates in Mesocricetus aureatus (Rodentia: Muridae was used to evaluate size variation lesion before and after after larval therapy with Lucilia sericata maggots. The criteria used for therapy evaluation were lesion size, maggot application time, and presence or absence of edema and secretions.
    Results.  Effective scarring and wound healing was observed after therapy with L. sericata larvae, i.e. 80% to 100% lesion area reduction after 12 hours.
    Conclusion. The preliminary results suggest that fly maggots of L. sericata have a potential use as natural medical and veterinary alternative therapy for the cutaneous leishmaniasis.

    Introducción. La terapia con larvas ha sido ampliamente utilizada para el tratamiento de lesiones ulcerativas de la piel; existen registros de enfermedades, como podopatía diabética, osteomielitis y úlceras varicosas, en las cuales el uso de la terapia con larvas ha promovido la cicatrización de la lesión en presencia de patógenos bacterianos resistentes a los antibióticos convencionales.
    Objetivo. Realizar una prueba piloto de terapia con larvas de Lucilia sericata sobre lesiones cutáneas producidas por Leishmania amazonensis.
    Materiales y métodos. En el presente trabajo se empleó un diseño experimental en animales ( Mesocricetus aureatus, tres réplicas con la finalidad de analizar las variaciones del tamaño de la lesión por leishmaniasis antes y

  17. Terapia de bioestimulación con plasma rico en plaquetas para el envejecimiento cutáneo Bioestimulation technique with rich plasma in platelets for skin aging

    OpenAIRE

    HM Escobar

    2012-01-01

    La bioestimulación con plasma rico en plaquetas es una técnica ambulatoria para la prevención y manejo del envejecimiento cutáneo, se basa en la fisiología de la piel y funciona muy bien sola o dentro de un plan terapéutico combinado. El derivado de sangre autóloga estimula la producción de colágeno, elastina y tejido epidérmico, lo que se traduce en piel más tersa, luminosa y de mejor calidad. Son mínimos los riesgos de formación de hematomas, infección, transmisión de enfermedades o reaccio...

  18. Fatores de risco para a não adesão ao tratamento com terapia antiretroviral altamente eficaz Factores de riesgo para la no-adherencia al tratamiento con terapia anti-retroviral altamente eficiente Risk factors for non-compliance to treatment with highly effective antiretroviral therapy

    Directory of Open Access Journals (Sweden)

    Maria Rosa Ceccato Colombrini

    2008-09-01

    Full Text Available O estudo objetivou: mensurar a prevalência de não-adesão à terapia anti-retroviral altamente eficaz (HAART em pacientes com AIDS; identificar se alguns fatores relacionados na literatura estavam associados com a não-adesão; estabelecer o valor preditivo dos fatores associados à não-adesão à HAART. Foi realizado um estudo analítico de prevalência (N=60. Foram considerados os três dias anteriores à entrevista e os pacientes classificados como aderentes quando ingeriam 95% ou mais do total de comprimidos prescritos por dia. A adesão foi de 73,3%. A análise de regressão logística multivariada indicou que indivíduos da raça negra apresentaram 6,48 vezes mais risco de não-adesão; aqueles que apresentaram ausência de efeito colateral tiveram um risco 7,6 vezes maior, e a cada comprimido ingerido o risco foi de 1,12. A adesão observada foi maior que a encontrada na literatura. Os fatores sociodemográficos e culturais podem interferir na adesão à HAART.Objetivo del estudio: medir la prevalencia por falta de seguimiento al tratamiento anti-retroviral altamente eficaz (HAART en pacientes con SIDA; identificar si algunos factores relacionados en la bibliografía se encuentran asociados con la falta de seguimiento; establecer el valor preditivo de los factores asociados con la falta de seguimiento al HAART. Para lo cual fue realizado un estudio analitico de prevalencia (N=60, considerándose los tres días anteriores a la entrevista, donde aquellos pacientes con ingesta del 95% o más del total de comprimidos prescritos por día eran clasificados como seguidores del tratamiento. El seguimiento fue de 73,3%. El análisis de regresion logística multi-variable mostró que sujetos de raza negra presentaron 6,48 veces mayor riesgo de no continuar con el tratamiento; aquellos individuos sin efectos colaterales tuvieron un riesgo 7,6 veces mayor, asimismo, cada comprimido ingerido produjo un riesgo de 1,12. El seguimiento observado fue

  19. The anti-thyroid antibody and I-131 uptake in thyroid disorder patient

    International Nuclear Information System (INIS)

    Faridul Alam; Fatema Sultana Haque; Mohammad Abdul Karim; Liaquat Ali; Omer Faruque; Azad Khan, A.K.

    2004-01-01

    The problem of thyroid disorder is extensive in Bangladesh, even more than that of other developing countries. The high incidence rate of goiter is reduced after universal iodine supplement. This study has been undertaken to study the an-thyroid anti-body level among the thyroid disorder population (anti-TPO and anti-thyrogobulin antibody) and TSAb among Graves' disease and sub-acute thyroiditis. This study was performed over 300 persons of them 150 have some type of thyroid (patient) disorder and 150 have got no clinical thyroid disorder (volunteer). We also studied TSH receptor anti-body (TSAb) in 112 Graves' disease patients and 86 patients with sub-acute thyroiditis. All the patient had I-131 Uptake in 24 hours. Among the patient 42(28%) had elevated anti-TPO, 12(8%) had borderline and 96(64%) had normal anti-TPO. It was found the uptake percentage of this group of patient hade slight lower than average uptake of our population. 13±5% It was found that 28(18.6%) had elevated anti thyrogobulin anti-body, 9 (6.2%) had borderline and 113(75.3%) had normal level anti thyrogobulin anti-body. It was also that found the uptake percentage of this group of patient had slight lower than average uptake of our population. We also found that 21% patient had elevated both the antibodies. Among the normal volunteer 24(16%) had elevated anti-TPO, 8 (5.3%) had borderline and 118(78.7%) had normal level of anti-TPO. Thyroid 1-131 uptake was 15±4%. It was found that 14(9.3%) had elevated anti thyrogobulin anti-body, 6(4.1%) had borderline and 130 (76.6%) had normal level of anti thyrogobulin anti-body. Among the normal volunteer 6% had elevated both the antibodies. It was found 91% patient Graves' disease had positive TSAb and 92% of' sub-acute thyroiditis has negative TSAb, I-131 uptake was 31±8% among this group of patient.. Thyroid stimulating antibody is found in 91% of Graves' disease and very few patient with sub-acute thyroiditis. The uptake of I-131 in sub

  20. Estudo comparativo do consumo e gasto com medicamentos em Unidades Pediátricas de Terapia Intensiva e Semi-intensiva Estudio comparativo del consumo y gasto con medicamentos en Unidades Pediátricas de Terapia Intensiva y Semi-intensiva Comparative study of drug utilization and drug expenses in Pediatric Intensive and Semi-intensive Care Units

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    Larissa Lenotti Zuliani

    2012-01-01

    Full Text Available OBJETIVO: Descrever e comparar o consumo e gastos com medicamentos em Unidades de Terapia Intensiva (UTI e Semi-intensiva Pediátricas. MÉTODOS: Estudo descritivo, exploratório, retrospectivo, com abordagem quantitativa por meio de estatística descritiva simples. A coleta de dados ocorreu no período de junho de 2007 a maio de 2008 nas UTI e Semi-intensiva Pediátricas de um hospital de ensino do interior do Estado de São Paulo, utilizando-se a classificação ABC. RESULTADOS: O gasto médio/leito da Unidade Cardiológica foi de R$ 1.400,00±0,26 leito/mês e da Neonatal de R$ 1.530,00±0,27 leito/mês, sendo menor na UTI e Semi-intensiva Pediátrica (R$ 260,00±0,13 leito/mês. Houve variação significativa do gasto mensal com medicamentos independentemente da taxa de ocupação. Na Classe A, os dez medicamentos de maior custo representaram 57,1, 54,3, e 46,3% do orçamento das UTI e Semi-intensivas Cardiológica, Neonatal e Pediátrica, respectivamente. Na Neonatal, os dez medicamentos mais consumidos corresponderam à Classe C, com 6,6% do orçamento, enquanto que nas outras unidades se enquadram oito, responsáveis por 7,8% do orçamento da Cardiológica e 7,7% da Pediátrica. CONCLUSÕES: A classificação ABC permitiu conhecer o consumo e os gastos com medicamentos; esse método favorece a gestão desses recursos nas unidades avaliadas.OBJETIVO: Describir y comparar el consumo y los gastos con medicamentos en Unidades de Terapia Intensiva (UTI y Semi-intensiva Pediátricas. MÉTODOS: Estudio descriptivo, exploratorio, retrospectivo, con abordaje cuantitativo mediante estadística descriptiva simple. La recolección de datos ocurrió en el periodo de junio de 2007 a mayo de 2008 en las UTI y Semi-intensiva Pediátricas de un hospital de enseñanza en el interior del Estado de São Paulo, utilizándose la clasificación ABC. RESULTADOS: El gasto medio/lecho de las Unidades Cardiológicas fue de R$ 1.400,00±0,26 lecho/mes y Neonatal de

  1. Model of iodine metabolism in a T3-thyrotoxic patient undergoing I-131 therapy

    International Nuclear Information System (INIS)

    Ahuja, S.; Price, R.; Brill, A.B.; Dobyns, B.M.; Berman, M.

    Data on radioactivity in the thyroid, urine, serum, butanol-extractable iodine (BEI) and chromatographic fractionations of BEI, obtained during four I-131 therapeutic treatments of a T 3 -thyrotoxic patient, have been analyzed and simulated with the help of a 7-compartment model. Good fits to most of the data can be obtained with both the dose-independent and dose-dependent models. A model with 3 or 4 compartments, which provides adequate fits to iodine kinetic data in most euthyroid and hyperthyroid patients is not satisfactory in the case of this patient. Thus, to represent iodine metabolism during T 3 -thyrotoxicosis therapy, we find that it is necessary to provide for separate biochemical pathways for the BEI components as well as the butanol-insoluble compounds released by the thyroid gland

  2. Radioimmunoscintigraphy with I-131-labelled anti-CEA monclonal antibody in colorectal cancer patients

    International Nuclear Information System (INIS)

    Xie Tianhao

    1988-01-01

    Twenty three colorectal carcinoma and two benign polyposis patients with operatively and histologically proven were studied by radioimmunoscintigraphy, using anti-CEA monoclonal antibodies (C14-17 and C50) radiolabeled with I-131 . Computer assisted processing for the subtraction of Tc-99m background radioactivity was used to enhance the detection and localization of tumor which is visualized by immune scintigraphy. The size of tumor and the ratios of tumor to nontumor (T/NT) are two very important factors for the external immunoscintigraphy. The antibody uptake and retention in tumor are likely to depend on the degree of vascularity and diffusion into the viable tumor mass. Based upon the obtained results, the sensitivity of the method (true-poditive) was 91%, its specificity (true-negative) was 100%. This study thus indicates that radioimmunoscintigraphy of cancer with radioactive anti-CEA monoclonal antibody is very uaeful in the diagnoses of patients with CEA-containing neoplasms

  3. Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study

    International Nuclear Information System (INIS)

    Steinbach, J.J.; Donoghue, G.D.; Goldman, J.K.

    1979-01-01

    We report a prospective study to evaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of I-131 (RAI) therapy. Twenty-four male patients with toxic diffuse goiter were assigned randomly into two treatment groups: Group A received RAI treatment while on antithyroid drugs after attainment of euthyroidism; Group B received no antithyroid drugs before, or when, RAI was given. Patients in each group received a dose of RAI calculated to deliver approximately 5000 rads per treatment. The incidence of hypothyroidism at 12 mo was 8% for Group A and 36% for Group B (p 0.45). The improved therapeutic outcome of patients in Group A suggests that further validation of the method in a larger patient population, including females, is warranted

  4. Asistencia ventricular izquierda para terapia de destino: primera experiencia en septuagenarios

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    Sebastian V. Rojas

    2016-10-01

    Conclusiones: Nuestros resultados iniciales demuestran que el implante mínimamente invasivo de DAVI puede ser realizado de manera eficaz, segura y con buenos resultados en pacientes septuagenarios terapia de destino. Los bajos niveles de eventos adversos durante el seguimiento por 2 años demuestran que la terapia de destino puede ser realizada incluso en pacientes septuagenarios.

  5. Los ritmos como terapia para la impulsividad

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    Mónica Triviño

    2012-10-01

    Full Text Available Investigaciones recientes muestran que el uso de patrones rítmicos facilita la respuesta óptima en el tiempo, por lo que el entrenamiento mediante ritmos podría proponerse como terapia novedosa ante problemas como la impulsividad. Esto podría beneficiar a pacientes con daño prefrontal o personas con trastorno por déficit de atención e hiperactividad (TDAH, que suelen mostrar conductas impulsivas, así como dificultad para estimar el paso del tiempo.

  6. Terapia de bioestimulación con plasma rico en plaquetas para el envejecimiento cutáneo Bioestimulation technique with rich plasma in platelets for skin aging

    Directory of Open Access Journals (Sweden)

    HM Escobar

    2012-03-01

    Full Text Available La bioestimulación con plasma rico en plaquetas es una técnica ambulatoria para la prevención y manejo del envejecimiento cutáneo, se basa en la fisiología de la piel y funciona muy bien sola o dentro de un plan terapéutico combinado. El derivado de sangre autóloga estimula la producción de colágeno, elastina y tejido epidérmico, lo que se traduce en piel más tersa, luminosa y de mejor calidad. Son mínimos los riesgos de formación de hematomas, infección, transmisión de enfermedades o reacciones alérgicas.Biostimulation with rich plasma in platelets is an outpatient technique for the prevention and management of skin aging, which is based on the physiology of the skin, and works very well alone or in a combined treatment plan. Own patient derivate blood stimulates production of collagen, elastin and skin tissue, resulting in a smoother skin, brighter and better quality. Risks of bruising, infection, disease transmission or allergic reactions are minimal.

  7. Thyroid Dose Estimation Using WBC and I-131 Concentration in Working Area of Radioisotope Production at Normal Operation; Perkiraan Dosis Thyroid Melalui Pengukuran WBC dan Perhitungan dengan Konsentrasi I-131 Di Daerah Kerja Pada Operasi Normal Produksi Radioisotop

    Energy Technology Data Exchange (ETDEWEB)

    Tedjasari, R S; Lubis, E [Radioactive-Waste Management Technology Centre, National Atomic Energy Agency of Indonesia(Indonesia)

    1996-07-01

    Thyroid dose estimation at Radioisotope Production Centre workers using WBC and calculation based on I-131 concentration in working area has been done. The aim of this research is to get the relation between WBC result and calculation using I-131 concentration in working area. The result indicates differences in a range of 3,2% to 53,2%. These differences caused of parameters which influence the calculation are not accurate. These results also indicate that dose estimation using WBC is relatively batter and more accurate but need to have certain information about time of intake.

  8. Actitudes terapéuticas en terapia de pareja.

    OpenAIRE

    Rafael Manrique Solana

    1992-01-01

    El artículo expone diversas actitudes que un terapeuta puede desarrollar en la terapia con parejas. Estas actitudes pueden ser de dos tipos: 1. Aquellas actitudes generales que se han de sostener a lo largo de cualquier terapia. 2. Aquellas destinadas a establecer una adecuada relación terapéutica con la pareja. El conjunto de ambas actitudes permite establecer un marco de relación en el que la conversación terapéutica es posible.

  9. Use of I-131 labeled, murine Fab against a high molecular weight antigen of human melanoma: Preliminary experience

    International Nuclear Information System (INIS)

    Larson, S.M.; Carrasquillo, J.A.; McGuffin, R.W.

    1985-01-01

    High molecular-weight antigen (HMWA) is tumor-associated proteoglycan of human malignant melanoma. I-131 labeled Fab fragments of these specific antibodies were used for preliminary feasibility studies for radioimmunodetection and therapy of human subjects who had inoperable metastatic melanoma. Ten patients received tracer doses of I-131 (anti-HMWA) Fab. All patients (8/8) who had melanoma lesions greater than 1 cm by correlative diagnosis methods had one or more lesions that had localization to tumor of the radiolabelled Fab. In all, 17 of 23 (74%) documented metastases were seen. Two patients who had avid uptake received potentially radiotherapeutic doses. For both of these patients, whole imaging studies showed that the localization of the high dose I-131 Fab was predominantly in tumor. On whole body images, the anti-Fab HMWA appears to be more tumor selective than Fab preparations that target the p97 antigen for melanoma, and there is less uptake in liver

  10. A significant discrepancy of uptake between I-131 MIBG and F-18 FDG in a patient with malignant paraganglioma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Su; Kim, Hyun Keun; Choi, Kyu Young; Park, Hyung Ki; Kim, Eun Sil; Kim, Yun Kwon; Kim, So Yon [National Police Hospital, Seoul (Korea, Republic of)

    2007-06-15

    A 38-year-old man who was diagnosed with malignant paraganglioma underwent computed tomography (CT) and I-131 metaiodobenzylguanidine (MIBG) scan. CT showed extensive lymph node enlargement in right iliac area and retroperitoneum with severe hydronephrosis and mass on posterior bladder wall. However, I-131 MIBG scan didn't showed abnormal uptake. He also underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/CT for localizing accurate tumor site. F-18 FDG PET/CT showed multiple metastases of left supraclavicular, hilar, mediastinal para-aortic, inguinal, right iliac lymph nodes, lung, vertebrae, and pelvis. There are a few reports showing that the F-18 FDG PET/CT is helpful for staging and localizing tumor site of patients who are diagnosed with negative on the MIBG scans. Thus, we report a case with paraganglioma which showed negative I-131 MIBG scan, but revealed multiple intense hypermetabolic foci in F-18 FDG PET/CT.

  11. Medically-derived I-131: a potential tool for understanding the fate of wastewater nitrogen in aquatic systems

    Science.gov (United States)

    Rose, P. S.; Smith, J. P.; Aller, R. C.; Cochran, J. K.; Swanson, R. L.; Murthy, S. N.; Coffin, R. B.

    2010-12-01

    Iodine-131(t1/2 = 8 days) has been measured in Potomac River water and sediments in the vicinity of the Blue Plains Water Pollution Control Plant (WPCP), Washington, DC. The source of I-131 is medical, where it is commonly used to treat thyroid cancer and hyperthyroidism. Iodine is metabolized by patients and eliminated primarily in urine. While other medical radioisotopes may enter the environment via sewage effluent, the nature and quantity of treatments using I-131 cause it to account for much of the radioactivity in sewage effluent. Natural iodine in aquatic systems is biologically cycled similar to other nutrients, such as nitrogen. Iodine-131 concentrations measured in sewage effluent from Blue Plains WPCP and in the Potomac River suggest a relatively continuous discharge of this isotope. Dissolved I-131 shows a strong, positive correlation with δ15N values of nitrate in the river. The range of I-131 concentrations detected in surface waters is 0.18 ± 0.01 to 0.68 ± 0.02 Bq/L. Surface water δ15NO3 values ranged from 8.7 ± 0.3 to 33.4 ± 7.3 ‰ with NO3+NO2 concentrations between 0.38 ± 0.02 and 2.79 ± 0.13 mgN/L. Sediment profiles of particulate I-131 and δ15N indicate rapid mixing or sedimentation and in many cases remineralization of a heavy nitrogen source consistent with wastewater nitrogen. Iodine-131 concentrations in sediments ranged from 1.31 ± 0.8 to 117 ± 2 Bq/kg dry weight. Values of δ15N in sediments ranged from 4.7 ± 0.1 ‰ to 9.3 ± 0.1 ‰. We propose that I-131 coupled with δ15N can be an excellent tracer for the short-term fate of wastewater nitrogen in this system. However, the utility of I-131 as a tracer is not limited to use in the Potomac River. Other studies have documented the presence of I-131 in several aquatic systems and continuous discharges of this radioisotope in sewage effluent are likely to be widespread in urban environments.

  12. The Assessment of I-131 Internal Doses of Nuclear Medicine Workers in Korea Using Thyroid uptake system

    International Nuclear Information System (INIS)

    Bahn, Young Kag; Oh, Gi Back; Lee, Chang Ho; Lee, Jong Doo; Yeom, Yu Sun; Hwang, Young Muk

    2012-01-01

    There are possibilities the radiation workers could intake the radiation when workers deal with radiation-materials. Therefore, internal radiation doses of radiation workers need to be assessed. Although an application of the nuclear medicine is continuously increased in Korea, there is not a proper tool and form to monitor the internal doses of nuclear medicine workers. However, it is possible to attain the internal doses of I-131 to evaluate using thyroid uptake and well count system. In this study, we measured and evaluated the I-131 internal doses of nuclear medicine workers in Korea using thyroid uptake and well count system and performed an air sampling

  13. Lung uptake on I-131 therapy and short-term outcome in patients with lung metastasis from differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Okamoto, Shozo; Shiga, Tohru; Uchiyama, Yuko; Manabe, Osamu; Kobayashi, Kentaro; Yoshinaga, Keiichiro; Tamaki, Nagara

    2014-01-01

    It is sometimes difficult to assess I-131 lung uptake at the initial I-131 therapy because of strong artifacts from I-131 uptake in the thyroid bed. The aim of this study was to analyze the lung uptake at the second I-131 therapy for lung metastasis in patients who did not have lung uptake at the initial therapy from differentiated thyroid carcinoma (DTC). Then, we also analyzed the relationship between the initial lung uptake and short-term outcome after I-131 therapies. This study included 62 DTC patients with lung metastasis. The patients were classified into 2 groups according to the lung uptake at the initial I-131 therapy such as patients with lung uptake (positive uptake group n=31) and those without lung uptake (negative uptake group n=31). The lung uptake was analyzed at the second therapy in both groups. The short-term outcome was also analyzed based on the CT findings of lung metastasis size and serum thyroglobulin level between the two groups. The positive uptake group showed positive lung uptake at the second therapy in 23 patients (74%), whereas none of negative uptake group showed any lung uptake at the second therapy (P < 0.01). The positive uptake group significantly decreased in the size of lung metastasis from the initial therapy to the second therapy (20.0 ± 11.7 to 16.6 ± 9.6 mm, P < 0.01) with further decrease after the second therapy (P < 0.05). The serum thyroglobulin level was also significantly decreased from the initial therapy to the second therapy (4348 ± 7011 to 2931 ± 4484 ng/ml, P < 0.05). In contrast, the negative uptake group significantly increased in the size of lung metastasis from the initial therapy to the second therapy (17.3 ± 12.2 to 19.9 ± 14.3 mm, P < 0.01) with further increase after the second therapy (P < 0.01). No patients without lung uptake at the initial I-131 therapy showed lung uptake at the second therapy, or showed treatment effect. Therefore, second I-131 therapy for these patients with initially

  14. Terapia combinada con timolol/dorzolamida versus timolol/pilocarpina en el glaucoma primario de ángulo abierto Combined therapy with timolol and dorzolamide vs timolol and pilocarpine used in primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Frank García González

    2006-06-01

    Full Text Available El propósito de este trabajo fue evaluar la eficacia de la terapia combinada, timolol/dorzolamida, en comparación con timolol/pilocarpina. Se empleó tratamiento médico en 38 pacientes con glaucoma primario de ángulo abierto, a los que se les colocó en forma aleatoria timolol 0,5 %/dorzolamida 2 % (n. 19 o timolol 0,5 % y pilocarpina 2 % (n. 19 y posteriormente se analizaron los descensos de presión intraocular, efectividad durante cuatro semanas, efectos adversos locales y sistémicos. En el grupo de pacientes tratados con timolol/dorzolamida la presión intraocular media inicial (sin tratamiento descendió de 22,84 ± 1,77 mm Hg hasta 18,24 ± 1,84 mm Hg a las cuatro semanas de tratamiento, p. 0,01 (reducción de 4,60 mm Hg 22,14 %. En el grupo de pacientes tratados con timolol/pilocarpina la presión intraocular media inicial (sin tratamiento descendió de 23, 06 ± 1,29 mm Hg hasta 19,07 ± 1,23 mm Hg a la cuarta semana de tratamiento, p. 0,01 (reducción de 3,95 mm Hg /17,31 %, no se observaron diferencias significativas (p > 0,05 entre ambos tratamientos y fueron igualmente eficaces para reducir la presión intraocular. La calidad de vida de los pacientes que recibieron la dorzolamida como tratamiento coadyuvante fue superior, la dosificación disminuyó con respecto a la pilocarpina y no se presentaron efecto secundarios, tales como limitaciones para conducir y leer o dolor ocular, aunque refirieron sabor amargo cinco pacientes (26,31 % e irritación conjuntival dos pacientes (10,52 % relacionados con la dorzolamida. A mediano plazo se obtiene disminución de presión intraocular con dorzolamida como con la pilocarpina combinadas con el timolol. La dorzolamida demostró menos interferencia con la calidad de vida que la pilocarpinaThe objective of this study was to evaluate the efficacy of combined therapy with timolol and dorzolamide compared to timolol and pilocarpine. Thirty eight patients with primary open-angle glaucoma were

  15. Hiperlipidemia e intolerancia a la glucosa en un grupo de pacientes infectados con VIH que reciben terapia antirretrovírica hiperactiva Hyperlipidemia and glucose intolerance in patients with HIV infection receiving antiretroviral therapy

    Directory of Open Access Journals (Sweden)

    Carlos José Castro-Sansores

    2006-06-01

    Full Text Available OBJETIVO: Determinar la prevalencia de los efectos secundarios sobre el metabolismo de los lípidos y la glucosa provocados por la terapia antirretrovírica hiperactiva (TARHA, así como el impacto que el uso de los distintos esquemas de antirretrovíricos tiene sobre los lípidos y la glucosa en un grupo de pacientes de Yucatán, México. MATERIAL Y MÉTODOS: Se realizó un estudio transversal. A cada paciente se le aplicó un cuestionario creado para este estudio y se le determinaron los valores de colesterol total, triglicéridos y glucosa en ayuno. Se determinó la prevalencia de hiperlipidemia y alteraciones de la glucosa y su relación con las variables de la encuesta RESULTADOS: Se estudiaron 211 pacientes, 36 (17% mujeres y 175 (83% hombres; 92 (44% tuvieron hiperlipidemia. De éstos, 43 (20% presentaron hipercolesterolemia (HC y 82 (39% hipertrigliceridemia (HT. La presencia de HC e HT combinadas se verificó en 30 (14% pacientes; además, 19 (9% pacientes exhibieron alteraciones en la glucosa, seis (3% presentaron diabetes mellitus y 13 (6%, intolerancia a la glucosa. Las variables que se vincularon con la presencia de hiperlipidemia fueron los números de linfocitos CD4 >350 células/µl [RM= 2.79 (1.08-7.27, p= 0.03], el género masculino [RM= 3.6 (1.4-9.12, p= 0.006] y el uso de nucleósidos inhibidores de la transcriptasa inversa (NITI [RM= 3.1 (1.2-8.1, p= 0.01] CONCLUSIONES: Los pacientes con la infección por el VIH que reciben terapia antirretroviral (TAR tienen un riesgo aumentado de presentar dislipidemia. A diferencia de lo que informan la mayor parte las publicaciones, las alteraciones de los lípidos se asociaron con más frecuencia al uso de NITI, por lo que se concluye que la patogenia de estas alteraciones no es única y que resulta probable la existencia de un efecto sinérgico entre las distintas familias de fármacos antirretrovíricos y que otros factores del huésped participen en la génesis de estas alteraciones

  16. Beneficios de la terapia con hidroxiúrea en niños con anemia de células falciformes = Benefits of hidroxyurea therapy in children with sickle cell disease

    Directory of Open Access Journals (Sweden)

    Donado Gómez, Jorge Hernando

    2012-04-01

    Full Text Available Objetivo: describir la toxicidad y los beneficios de la hidroxiúrea (HU en el tratamiento de niños con anemia de células falciformes (ACF.Materiales y métodos: estudio observacional descriptivo-retrospectivo de pacientes con ACF tratados con HU en el Hospital Pablo Tobón Uribe (HPTU de Medellín, Colombia, entre mayo de 2004 y septiembre de 2009. Se trató con este medicamento a 16 pacientes menores de 15 años, 11 de ellos (68,8% de sexo masculino. Todos los pacientes tenían anemia falciforme (Hb SS. Las variables se estudiaron antes y después del inicio de la HU. Resultados: se encontró una media de crisis dolorosas por ACF de 3,31 antes y 1,13 después de la HU (p = 0,006; la media de la necesidad de transfundir glóbulos rojos fue de 2,69 antes y 0,75 después (p = 0,112; los episodios de síndrome torácico agudo (STA tuvieron una media de 0,19 antes y 0,13 después (p = 0,705; la media de la necesidad de hospitalización por ACF fue de 1,94 antes y 1,06 después de la HU (p = 0,155. Un paciente (6,3% presentó toxicidad hematológica y dos (12,5% tuvieron toxicidad hepática, pero no hubo casos de toxicidad renal; tres pacientes (18,8% presentaron accidentes cerebrovasculares. No se encontraron neoplasias. Conclusión: la HU redujo significativamente la frecuencia de crisis dolorosas en los pacientes con ACF. La toxicidad fue en general aceptable. Se requieren estudios prospectivos, multicéntricos, doble ciego, controlados con placebo, para definir el papel de la HU en pacientes pediátricos.

  17. Efecto de la aplicación de terapia conductual en la adquisición de destrezas básicas para el aprendizaje, en tres niños con autismoa partir de la expresión artística

    OpenAIRE

    Hannia Cabezas Pizarro

    2004-01-01

    El presente estudio muestra el efecto de la utilización de terapia conductual aplicada, en tres niños con autismo, y cuyo propósito fue el de desarrollar aquellas conductas de entrada básicas para el aprendizaje como son el permanecer sentados, el control de llanto, el establecimiento de contacto ocular y la identificación del yo, consideradas habilidades básicas que deben tener los niños para incursionar en el proceso educativo. Una vez que el niño adquiere esta gama ...

  18. Movimiento danza terapia

    OpenAIRE

    Tau, Vilma

    2011-01-01

    Movimiento Danza Terapia es una disciplina en construcción que se alimenta permanentemente de los aportes de las nuevas psicologías, el arte y los avances en neurociencia. Nace entre las décadas de 1930 y 1940 en los Estados Unidos, donde Marian Chace comenzó a explorar el uso terapéutico de la danza mientras enseñaba danza moderna en su estudio.

  19. Planar and SPECT Monte Carlo acceleration using a variance reduction technique in I131imaging

    International Nuclear Information System (INIS)

    Khosravi, H. R.; Sarkar, S.; Takavar, A.; Saghari, M.; Shahriari, M.

    2007-01-01

    Various variance reduction techniques such as forced detection (FD) have been implemented in Monte Carlo (MC) simulation of nuclear medicine in an effort to decrease the simulation time while keeping accuracy. However most of these techniques still result in very long MC simulation times for being implemented into routine use. Materials and Methods: Convolution-based forced detection (CFD) method as a variance reduction technique was implemented into the well known SlMlND MC photon simulation software. A variety of simulations including point and extended sources in uniform and non-uniform attenuation media, were performed to compare differences between FD and CFD versions of SlMlND modeling for I 131 radionuclide and camera configurations. Experimental measurement of system response function was compared to FD and CFD simulation data. Results: Different simulations using the CFD method agree very well with experimental measurements as well as FD version. CFD simulations of system response function and larger sources in uniform and non-uniform attenuated phantoms also agree well with FD version of SIMIND. Conclusion: CFD has been modeled into the SlMlND MC program and validated. With the current implementation of CFD, simulation times were approximately 10-15 times shorter with similar accuracy and image quality compared with FD MC

  20. I-131 therapy for hyperthyroidism in carbimazole induced acute aplastic anaemia

    International Nuclear Information System (INIS)

    Jenkin, B.A.; Van Every, B.; Kelly, M.J.

    1998-01-01

    Full text: We present a case of a 39 year old previously well woman who developed carbimazole-induced acute aplastic anaemia. Following 6 weeks of carbimazole for Grave's disease she presented with fever, sore throat and lethargy and was found to be pancytopaenic. Haemoglobin fell to 79g/l (normal>120g/l), neutrophils to an undetectable level and platelets to 4,000/ml (normal>150,000/ml). From the MIRD schema it was estimated that a therapeutic dose of 444 MBq (12mCi) to treat her hyperthyroidism would deliver a red marrow radiation dose of about 30 mSv, at least an order of magnitude below any expected demonstrable deleterious effect on the marrow. Subsequently a dose of 444 MBq of I-131 was given and within 2 weeks the marrow had begun to recover, eventually to normal. This case would support the use of 1-131 for hyperthyroidism in carbimazole-induced marrow aplasia, even in profoundly depressed marrow

  1. Estimation dose in organs of hyperthyroidism patients treated with I-131

    International Nuclear Information System (INIS)

    Farias de Lima, F.; Khoury, H.C.; Bertelli Neto, L.; Hazin, C.

    1997-01-01

    Full text: The absorbed dose in organs of hyperthyroidism patients, which received 370 MBq and 555 MBq of I-131 were estimated, using the MIRDOSE computational program and data of the ICRP-53 publication. The calculus were done considering an equal uptake to 45% and an effective half life of 5 days, these values are closed to the average values found in 17 studied patients. The thyroidal masses were previously determined by the physicians and varied between 40 g and 80 g The results showed that the dose in the thyroid, for an activity of 370 MBq, varied between 99 Gy and 49,5 Gy for the masses of 40 g and 80 g respectively. In the case of the administration of 555 MBq the patients had thyroidal masses between 60 g and 80 g and the doses varied between 99 Gy and 74,2 Gy, respectively. These values showed that the absorbed doses in thyroid are within limits expected for the hyperthyroidism therapy, which are of 506 Gy to 100 Gy. The 100 Gy dose would be exceeded, if the patients with thyroidal mass of 40 g had received a therapeutic dose of 555 MBq. The estimated media doses in others organs were relatively low, with inferior values of 0,1 Gy in kidneys, bone marrow and ovaries and of 0,19 Gy in stomach

  2. I-131 therapy for hyperthyroidism in carbimazole induced acute aplastic anaemia

    Energy Technology Data Exchange (ETDEWEB)

    Jenkin, B.A.; Van Every, B.; Kelly, M.J. [Alfred Hospital, Prahran, VIC (Australia). Nuclear Medicine Department

    1998-06-01

    Full text: We present a case of a 39 year old previously well woman who developed carbimazole-induced acute aplastic anaemia. Following 6 weeks of carbimazole for Grave`s disease she presented with fever, sore throat and lethargy and was found to be pancytopaenic. Haemoglobin fell to 79g/l (normal>120g/l), neutrophils to an undetectable level and platelets to 4,000/ml (normal>150,000/ml). From the MIRD schema it was estimated that a therapeutic dose of 444 MBq (12mCi) to treat her hyperthyroidism would deliver a red marrow radiation dose of about 30 mSv, at least an order of magnitude below any expected demonstrable deleterious effect on the marrow. Subsequently a dose of 444 MBq of I-131 was given and within 2 weeks the marrow had begun to recover, eventually to normal. This case would support the use of 1-131 for hyperthyroidism in carbimazole-induced marrow aplasia, even in profoundly depressed marrow

  3. Risk from ionizing radiation to the clinical staff and incidental public in the course of therapy with I-131

    International Nuclear Information System (INIS)

    Chas, J.; Janiak, M.K.; Kowalczyk, A.; Siekierzynski, M.; Dziuk, E.

    1997-01-01

    The aim of the study was to assess the risk to the personnel and neighbouring patients exposed to ionizing radiation during their stay at the Isotopic Therapy Clinic in Warsaw where therapeutic applications of I-131 are routinely performed. To this end, thermoluminescent dosimeters were deposited in various places throughout the Clinical ward and the absorbed doses were read after 125 days of the exposition. Additionally, exposure dose rates were determined at the skin surface over the thyroid gland at 0.5 and 1.0 m away from 71 patients treated with I-131 for hyperthyroidism or thyroid cancer (as a supplementary therapy after thyroidectomy) and the potential dose equivalents were calculated. From these values ''restriction times'', i.e., the amounts of time needed for the potential dose equivalents to decline below the limit recommended for occupational or public exposures to ionizing radiation were derived. The results indicate that - a) the probability to exceed the recommended annual dose limit by the personnel (50 mSv y -1 ) and neighbouring patients not subjected to radiotherapy (1 mSv y -1 ) during their exposition at the Isotopic Therapy Clinic to the I-131 treated patients is practically equal to zero; b) no restrictions in terms of limiting the duration of contact with the I-131-treated patients are necessary during the occupational exposures of the personnel of the Clinic; and c) the treated patients may incur some risk to the general public only when injected with high doses of I-131 and/or only within about 3 days upon the application of the radionuclide. (author)

  4. Maximal safe dose therapy of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Lee, Jong Jin; Seok, Ju Won; Uh, Jae Sun

    2005-01-01

    In patients with recurrent or metastatic differentiated thyroid carcinoma, residual disease despite repetitive fixed dose I-131 therapy presents an awkward situation in terms of treatment decision making. Maximal safe dose (MSD) administration base on bone marrow radiation allows the delivery of a large amount I-131 to thyroid cancer tissue within the safety margin. We investigated the efficacy of MSD in differentiated thyroid cancers, which had persisted after conventional fixed dose therapy. Forty-six patients with differentiated thyroid carcinoma who had non-responsible residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. The postoperative pathology consisted of 43 papillary carcinomas and 3 follicular carcinomas. MSD was calculated according the Memorial Sloan Kettering Cancer Center protocol using blood samples. MSDs were administered at intervals of at least 6 months. Treatment responses were evaluated using I-131 whole body scan (WBS) and serum thyroglobulin measurements. Mean calculated MSD was 12.5±2.1 GBq. Of the 46 patients, 6 (13.0%) showed complete remission, 15 (32.6%) partial response, 19 (41.3%) stable disease, and 6 (13.0%) disease progression. Thus, about a half of the patients showed complete or partial remission, and of these patients, 14 (67%) showed response after a single MSD administration and 6 (29%) showed response after the second dose of MSD administrations. Twenty-nine patients (63%) experienced transient cytopenia after therapy, and recovered spontaneously with the exception of one. MSD administration is an effective method even in the patients who failed to be treated by conventional fixed dose therapy. MSD therapy of I-131 can be considered in the patients who failed by fixed dose therapy

  5. Comparison of I-131 MIBG scintigrapy and F-18 FDG PET in neuroblastoma

    International Nuclear Information System (INIS)

    Pai, M.; Lee, S.; Yoo, E

    2004-01-01

    The purpose of this preliminary study was to compare the utility of metaiodobenzylguanidine(MIBG) scintigraphy and F-18 FDG PET for the detection of primary and metastatic lesions of neuroblatoma. F-18 FDG PET and I-131 MIBG scan or SPECT were performed with in 1 month of each other in 4 patients (age: 4-5, all female) with known neuroblastoma after primary treatment. In 3 of 4 patients with confirmed neuroblastoma, FDG PET and MIBG scans were concordant for the presence or absence of diseased sites. In two cases, residual abdominal masses less than 1cm in which the X -ray computed tomography showed no change in tumor volume had a simultaneous negative uptake in both MIBG scan and FDG PET. In a patient with histologic evidence of bone marrow involvement, there was no skeletal uptake of both MIBG and FDG but Tc-99m HDP bone scan revealed disseminated bone marrow involvement, while a large mediastinal primary mass of this patient showed intense MIBG and FDG uptake. In one patient whose large abdominal mass of neuroblastoma failed to accumulate FDG, MIBG uptake in the tumor was intense. We concluded that FDG PET could reveal metabolic state of primary or residual neuroblastoma as much as MIBG in majority of our cases but it did not show any advantages over MIBG or even bone scan. FDG PET had an obvious defect in detection of residual viable disease in one patient. FDG PET may not replace MIBG or bone scan for evaluation of primary or metastatic disease of neuroblastoma in the diagnostic and staging procedure from INSS recommendation

  6. Comparison of I-131 MIBG scintigrapy and F-18 FDG PET in neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Pai, M.; Lee, S.; Yoo, E [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2004-07-01

    The purpose of this preliminary study was to compare the utility of metaiodobenzylguanidine(MIBG) scintigraphy and F-18 FDG PET for the detection of primary and metastatic lesions of neuroblatoma. F-18 FDG PET and I-131 MIBG scan or SPECT were performed with in 1 month of each other in 4 patients (age: 4-5, all female) with known neuroblastoma after primary treatment. In 3 of 4 patients with confirmed neuroblastoma, FDG PET and MIBG scans were concordant for the presence or absence of diseased sites. In two cases, residual abdominal masses less than 1cm in which the X -ray computed tomography showed no change in tumor volume had a simultaneous negative uptake in both MIBG scan and FDG PET. In a patient with histologic evidence of bone marrow involvement, there was no skeletal uptake of both MIBG and FDG but Tc-99m HDP bone scan revealed disseminated bone marrow involvement, while a large mediastinal primary mass of this patient showed intense MIBG and FDG uptake. In one patient whose large abdominal mass of neuroblastoma failed to accumulate FDG, MIBG uptake in the tumor was intense. We concluded that FDG PET could reveal metabolic state of primary or residual neuroblastoma as much as MIBG in majority of our cases but it did not show any advantages over MIBG or even bone scan. FDG PET had an obvious defect in detection of residual viable disease in one patient. FDG PET may not replace MIBG or bone scan for evaluation of primary or metastatic disease of neuroblastoma in the diagnostic and staging procedure from INSS recommendation.

  7. Exposure of employees engaged on the production and quality control of radiopharmaceuticals labelled with Tc-99m and I-131

    International Nuclear Information System (INIS)

    Trtic, T.; Jovanovic, M.; Vranjes, S.; Vucina, J.; Vuksanovic, Lj.

    1995-01-01

    In this paper, the analysis is presented, of exposure control of employees in the Laboratory for radioisotopes, of the Vinca Institute of nuclear sciences, engaged in the production and quality control of the Tc-99m generator and radiopharmaceuticals labelled with Tc-99m and I-131. Effective doses equivalent (mSv) was measured by personal thermoluminescent dosimeter in the Laboratory for radiation and environmental protection each month. We calculated effective dose equivalents for each year in the period 1986-1990. Thirty one employees were analysed. They were separated into the groups both on the basis of radioisotope which they worked with and the kind of the professional work. The highest average effective doses equivalent were received in the group producing of Tc-99m generator (4-12.5 mSv) and in the group producing I-131 radiopharmaceuticals (3.55-13.73 mSv). (author)

  8. Autonomous Functioning Thyroid Nodule in a 4-year-old Male Child Treated with Radioiodine (I-131)

    International Nuclear Information System (INIS)

    Khare, Abhishek; Bhutani, Puneet; Chauhan, Suneel

    2013-01-01

    Autonomous functioning thyroid nodules that cause toxic manifestations (toxic adenomas) are benign monoclonal tumors characterized by their capacity to grow and produce thyroxine (T4) and triiodothyronine (T3) autonomously, i.e. in the absence of thyrotropin thyroid stimulating hormone. Toxic adenomas are a rare presentation of hyperthyroidism in the pediatric population. Radioiodine (I-131) has been widely used for therapy of patients with toxic adenomas and is now accepted as a safe and effective treatment even in the pediatric age group. The authors here present a case of a 4-year-old boy with a solitary hyperfunctioning thyroid nodule, who was successfully treated with radioiodine (I-131) and is presently on follow-up

  9. Evaluation of absorbed dose in studies of renal function due to 123I/131I (hippuran) e 111In (DPTA)

    International Nuclear Information System (INIS)

    Vasquez, M.V.; Castillo, C.E.; Rojas, R.; Cabrera, C.; Abanto, D.; Morgan, A.; Diaz, E.E.

    2015-01-01

    The absorbed dose of the kidneys during renal function studies of adult patients is estimated through biokinetics of radiopharmaceuticals containing the 123 I/ 131 I (hippuran) e 111 In (DPTA). Using the methodology MIRD and representation Cristy-Eckerman for adult kidneys, it is shown that dosimetric contributions of organs of biokinetics 123 I/ 131 I (hippuran) e 111 In (DPTA) are significant, in estimative of dose for renal function studies. Dosimetric contributions (body and whole bladder, kidneys excluding) are given by 11.90% (for 123 I), 4.97% (for 131 I) and 28.32% (for 111 In). In all cases, the dosimetric contributions are mainly due to photons issued by the whole body

  10. Role of trophallaxis in the dispersal of radioactive I131 and of bacterial infections in the termite, Bifiditermes beesoni

    International Nuclear Information System (INIS)

    Khan, K.I.; Jafri, R.H.; Ahmad, M.

    1981-01-01

    Dispersal and localisation of radioactive iodine (I 131 ) through trophallaxis was studied in various organs of healthy or bacteria-infected pseudergates of Bifiditermes beesoni. The breakdown of the defence system by bacterial pathogens was also studied by means of I 131 . Individual groups of pseudergates of B. beesoni were infected by various bacterial pathogens, i.e. Thuricide-HP (commercial preparation of Bacillus thuringiensis), B. thuringiensis 11-toumanoffi, B. thuringiensis serotype 3a, 3b, Pseudomonas fluorescens and Serratia marcescens, respectively. Healthy pseudergates retained more radioactivity in their guts and less in their exoskeletons. However, bacteria-infected 'donor' and 'recipient' pseudergates and soldiers retained less radioactivity in their guts and more in their exoskeletons. The flow of radioactivity from gut towards exoskeleton or other parts of B. beesoni pseudergates occurred after destruction and breakdown of the inestinal defence system of the host. (orig.) [de

  11. Las posibilidades de la terapia génica y sus dilemas bioéticos

    OpenAIRE

    Mejía, Orlando

    2005-01-01

    La terapia génica tiene, de acuerdo con Anderson, cuatro niveles de aplicación: las células somáticas, las células germinales, la terapia perfectiva y la manipulación eugenésica. Se hace un análisis de los dilemas bioéticos en cada nivel de terapia y se plantea el denominado Argumento Evolutivo para cuestionar los deseos de algunos científicos de iniciar terapia génica de células germinales. De igual manera, se advierte de los peligros de iniciar terapia perfectiva y la manipulación eugénica ...

  12. Guide for the putting int practice the control of internal contamination due to I-131 in hospitals

    International Nuclear Information System (INIS)

    1988-01-01

    The generalized use of radioactive installations in different branches of the Economy and Medicine makes essential the existence of a radiological surveillance systems that guarantees that exposure are kept within the limits established. Nuclear medicine workers in hospitals that handle I-131 constitutes a professional group that can be internally contaminated the aim of this guide is to give the entity the general instructions and the necessary methodology to fulfill the control of the internal contamination by this radionuclide

  13. Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans

    International Nuclear Information System (INIS)

    Park, Eun-Kyung; Lee, Dong Soo; Lee, Myung Chul; Chung, June-Key; Lim, Il Han; Park, Do Joon; Cho, Bo Youn

    2009-01-01

    Serum Tg and I-131 WBS have been used to detect recurrent and metastatic thyroid cancers postoperatively. Tg is known to be more sensitive than I-131 WBS, and therefore, false-negative WBS cases with elevated Tg levels are frequently found. However, the clinical characteristics of false-negative Tg cases with positive WBS have not been clarified. The authors evaluated 824 postoperative patients with differentiated thyroid carcinoma who underwent post-ablation/therapy I-131 WBS. Tg negativity was defined as a Tg level of ≤2 ng/mL without TgAb under thyroid-stimulating hormone stimulation. Remission, recurrence, and metastasis were confirmed using pathologic or clinically findings. Fifty-two patients (6.3%) with functioning metastasis and negativity for TgAb were Tg-negative and posttherapy I-131 WBS-positive (TgN group), and 128 patients with functioning metastases were Tg positive and WBS positive (TgP group). The TgN group consisted of 45 cases of cervical/mediastinal lymph node metastases (86.5%) and seven cases of distant metastasis to lung or bone by follow-up WBS. The TgN group demonstrated significantly higher profiles of regional involvement than the TgP group (P < 0.029). In 47 patients in the TgN group, metastatic uptake disappeared in 33, ameliorated in four, and persisted in ten during follow-up. A significant number of differentiated thyroid cancer patients were Tg-/TgAb-negative despite a positive WBS finding. Cervical and mediastinal lymph nodes were predominant sites of metastasis in the TgN group. WBS should be undertaken routinely as a complementary modality to detect functioning recurrence and metastasis regardless of serum Tg results. (orig.)

  14. Off-shore contamination by I-131 and Cs-137 from the Fukushima Daiichi nuclear power station accident

    International Nuclear Information System (INIS)

    Pereira, Wagner de Souza; Kelecom, Patrick Vicent; Miyashita, Erika; Universidade Federal Fluminense; Kelecom, Alphonse

    2011-01-01

    On March 11, 2011 the biggest earthquake ever registered in Japan severed off-site power supply to the Fukushima Daiichi Nuclear Power Station. Backup diesel generators began providing electricity to pumps circulating coolant to the reactors, but were knocked out by a large tsunami and the nuclear site lost the ability to maintain proper reactor cooling. This was the beginning of a huge nuclear accident that was assigned an INES maximum rating of 7. On March 21, Japanese authorities reported that the Tokyo Electric Power Company (TEPCO) had detected radioactive materials in seawater. Radioactivity started to be measured by the Japan Atomic Energy Agency every two days in sea water from eight locations, 30km from the coastline. I-131 and Cs-137 were analyzed among other radionuclides. It is the aim of this paper to gather all this information and to discuss the evolution of the radioactive marine contamination during the first month of the accident. Results indicate for surface seawater concentrations ranging from 24.9 to 161.0 Bq/L for I-131 and 11.2 to 186.0 Bq/L for Cs-137, and for deep waters of 1.59-15.0 Bq/L (I-131) and 0.0-11.4 Bq/L (Cs-137). The I-131 concentrations in superficial waters were at or above Japanese regulatory limits in the first days, then lowered during one week to increase again above limits when TEPCO released contaminated water into the ocean, to finally reach not detectable values the last week of April. With the exception of point 4, on April 15, the Cs-137 levels were always well below regulatory limits. (author)

  15. Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Lee, Jong-Jin; Chung, June-Key; Kim, Sung-Eun; Kang, Won-Jun; Park, Do-Joon; Lee, Dong-Soo; Cho, Bo-Youn; Lee, Myung-Chul

    2008-01-01

    The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. Forty-seven differentiated thyroid carcinoma patients with non-responsive residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. Their postoperative pathologies were 43 papillary carcinomas and 4 follicular carcinomas. The MSD was calculated with the Memorial Sloan-Kettering Cancer Center protocol using serial blood samples. The MSDs were administered at intervals of 6 months. Treatment responses were evaluated using I-131 whole-body scans and serum thyroglobulin measurements. The mean calculated MSD was 12.5±2.1 GBq (339.6±57.5 mCi). Of the 46 patients, 7 (14.9%) showed complete remission, 15 (31.9%) partial remission, 19 (40.4%) stable disease, and 6 (12.8%) disease progression. Of the patients who showed complete or partial remission, 15 (65%) showed response after the first MSD session and 6 (26%) showed response after the second session. Twenty-nine patients (62%) experienced transient cytopenia after therapy, but three did not recover to the baseline level. The maximal safe dose provides an effective means of treatment in patients who failed to respond adequately to conventional fixed dose therapy. I-131 MSD therapy can be considered in patients who fail fixed dose therapy. (author)

  16. Iodine capsules in thyroid therapy: An individually controlled study of I-131 uptake kinetics as compared to liquid administration

    International Nuclear Information System (INIS)

    von Schulthess, G.K.; Seelentag, W.W.; Pfeiffer, G.; Blauenstein, P.; Bekier, A.

    1984-01-01

    The aim of this study was to determine the additional radiation dose sustained by parts of the patients gastric mucosa when given I-131 therapy in capsular rather than liquid form, and thus to establish the safety of this procedure. 16 patients with benign thyroid disease were studied by measuring serum radioactivity at 0, 5, 10, 20, 40, and 80 min. after administration of the capsule (120-200 MBq I131). These serum uptake values were compared to the uptake after administration of a liquid diagnostic dose of I-131 (2 MBq). From the resulting uptake curves the delay due to capsular dissolution was determined. The average dissolution time was found to be 12 min. with a large standard deviation of 7 min. Also, a theoretical curve was computed to indicate the dose rate as a function of the distance from the surface of the capsule. Based on this information the maximum dose to the gastric mucosa is of the order of 250 cGy for a therapeutic activity of 185 MBq, which is the maximum dose which may be given as single application to outpatients in Switzerland. By having the patient swallow some liquid during the first ten minutes, the capsule can be made to move around, and hence, the local radiation dose can be reduced substantially. The authors conclude, that I-131 in capsular form is a safe galenic form for therapeutic use in patients with thyroid disease. When large doses are given, administration of the dose in several capsules may be advisable

  17. A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst

    Directory of Open Access Journals (Sweden)

    Avneet K. Singh

    2017-01-01

    Full Text Available Thyroid carcinoma is the most common endocrine malignancy in the United States with increasing incidence and diagnosis but stable mortality. Differentiated thyroid cancer rarely presents with distant metastases and is associated with a low risk of morbidity and mortality. Despite this, current protocols recommend remnant ablation with radioactive iodine and evaluation for local and distant metastasis in some patients with higher risk disease. There are several case reports of false positive results of metastatic surveys that are either normal physiologic variants or other pathological findings. Most false positive findings are associated with tissue that has physiologic increased uptake of I-131, such as breast tissue or lung tissue; pathological findings such as thymic cysts are also known to have increased uptake. Our case describes a rare finding of a thymic cyst found on a false positive I-131 metastatic survey. The patient was taken for surgical excision and the final pathology was a benign thymic cyst. Given that pulmonary metastases of differentiated thyroid cancer are rare, thymic cysts, though also rare, must be part of the differential diagnosis for false positive findings on an I-131 survey.

  18. Radioiodine (I-131) application in the management of differentiated thyroid cancer (DTC) audit

    International Nuclear Information System (INIS)

    Nanayakkara, D.

    2005-01-01

    Full text: Differentiated thyroid cancer (DTC) remains one of the curable of all cancers. All literature reviews and clinical experiences regarding I 131 use in DTC conclude the beneficial effects, better prognosis, longer survival time and an assurance for cure. The Overall prognosis of patients with DTC is excellent if treat scientifically, adequately and timely. The management of thyroid cancer depends on the resources available in different institutions. Nuclear Medicine unit (NMU), Faculty of Medicine Peradeniya, Sri Lanka is in the process of uplifting the services for thyroid cancer management. Clinical audit was carried out in NMU on patients who utilized the Nuclear Medicine facilities in the management of DTC. It is important to identify deficiencies in current practice to improve our services. During January 2004 to March 2005, 126 DTC patients were referred for radioiodine Whole body scan (WBS) and therapy. Their age, sex, histology, extent of surgery, adequacy of thyroxine suppression treatment, monitoring with serum thyroglobulin levels (Tg), WBS results and radioiodine therapy were analyzed. There were 104(82.5%) females and 22(17.5%) males giving sex ratio of 4.7: 1. The Mean age was 35.5 years (range 9-58 years). The commonest histological types were papillary carcinoma 55.5% (n=70), follicular carcinoma 35% (n=44) and follicular variant of papillary carcinoma 9.5% (n=12). Seventy five percent (n=95) had total thyroidectomy (TT), 17 %(n=21) had near total thyroidectomy (NTT) and 8%(n=10) had subtotal thyroidectomy (STT). Sixty-nine patients (54.8%) were on thyroid suppression therapy. Thirty-six patients (28.6%) were referred to the WBS soon after surgery without initiation of thyroxine treatment. Another twenty-one patients (16.6%) were not on thyroxine therapy since surgery. Serum thyroglobulin was assessed on 20.6% (n=26). WBS done using 3-4 mCi liquid radioiodine showed residual functioning thyroid tissues in 41% (n=52). Lymph nodes or bone

  19. No hypothyroidism after I-131 therapy in pts with toxic nodular goiter, treated under combined thyreostatic, thyreomimetic medication

    International Nuclear Information System (INIS)

    Giubbini, R.; Panarotto, M.B.; Paghera, B.; Pagliaini, R.; Pajoro, U.; Pizzocaro, C.; Rossini, P.L.; Terzi, A.; Maira, G.

    2002-01-01

    Background. Treatment of toxic nodular goiter with 131-I is generally satisfactory and will cause a reversion of hyperthyroidism. To avoid the risk of thyrotoxic storm I-131 therapy is usually performed after pre-treatment with antithyroid drugs, which causes a TSH increase and functional recruitment of previously inhibited normal thyroid tissue. In this functional state both autonomous nodule(s) and normal tissue are irradiated after I-131 administration. This may be the reason of late hypothyroidism occurring in 15-25% of Pts. Aim of the study was the evaluation of a different pre-treatment modality with combined methimazole (10-20 mg) and Triiodo-thyronine (T3 - 60 μg) in order to treat pts in euthyroid state with suppressed TSH. Study protocol. After diagnosis of hyperthyroidism with autonomous functioning tissue the pts were put under thyreostatic medication. Two months later TSH was checked and if >0.5% U.I the T3 treatment was associated. After two more months, the TSH level was checked again and, if suppressed, the pt received I-131 therapy. Study population. 93 pts (74f, 19m - age 75±10) were consecutively enrolled. 24 pts had a toxic nodular goiter and 69 a multi nodular one, respectively; they were evaluated at diagnosis, at pre-treatment, two months after therapy and at late follow-up (3.1 ± 3.5 yrs). Methods: 557±225 MBq of I-131 (according to uptake determinations and gland weight) were administered. Methymazole was discontinued 3 days before treatment whereas T3 was maintained during I-131 therapy. Results: Euthyroidism was achieved after the first treatment in 71% of pts. At late follow-up TSH values over the normal range were observed in only 4 pts (4.3% - however all 4 pts had TSH level below 6 I.U.). Summaries of FT3 and FT4 values are presented. Conclusions: The treatment of toxic nodular goiter under combined thyreostatic-thyreomimetic treatment is a safe, well tolerated and effective procedure allowing a 71% success at the first treatment

  20. Células madre y terapia celular

    Directory of Open Access Journals (Sweden)

    Elso Manuel Cruz Cruz

    2015-03-01

    Full Text Available Una célula madre (CM o célula troncal es aquella capaz de dividirse indefinidamente y diferenciarse a distintos tipos de células especializadas, no sólo morfológica sino también funcionalmente. Las células madre pueden clasificarse atendiendo a su origen en células madre adultas (CMA y células madre embrionarias (CME. Por sus características, las CM tienen potencialidades para diversos usos en la práctica clínica. La primera es como vehículo terapéutico de genes, en el caso de enfermedades monogénicas o incluso como vehículo de terapias antitumorales o antiangiogénicas. La segunda y principal aplicación es, aprovechando su potencial de diferenciación, en la regeneración de tejidos destruidos o dañados, como terapia de reemplazo celular o medicina regenerativa. En esta área se están desarrollando trabajos de investigación donde se busca reemplazar células dañadas por otras que restituyan la función normal de los tejidos u órganos; en enfermedades como: diabetes mellitus, enfermedades cardiovasculares, enfermedad de Parkinson y enfermedades de células sanguíneas. Actualmente existen muchas investigaciones enfocadas a descubrir células progenitoras que sirvan como banco de células para usos terapéuticos. Se reporta el empleo de varias estrategias, las que incluyen: terapias celulares derivadas de células autólogas; terapias celulares derivadas de líneas celulares establecidas desde una variedad de CM que incluyen MO, cordón umbilical, CME, así como células de tejidos y órganos de animales genéticamente modificados. Las principales aplicaciones se realizan con CM de la médula ósea (MO, ya que esta es un recurso celular propio, accesible y abundante para la terapia celular. (1 En la MO existe un grupo heterogéneo de CMA; además de las hematopoyéticas (CMH están las: endoteliales, mesenquimales (CMM, de la población lateral, progenitoras adultas multipotentes, ovales y también células madre muy peque

  1. Reflexiones humanistas sobre conocimiento y servicios en terapia física, terapia ocupacional y terapia del lenguaje

    OpenAIRE

    Marie Luise H. de Alvarado; Clemencia Cuervo E.; Alicia Trujillo R.

    1986-01-01

    Este artículo constituyó la ponencia central del XX Aniversario de las Carreras de Terapia Física, Terapia Ocupacional y Terapia del Lenguaje en la Universidad Nacional de Colombia, celebrado en marzo de 1986. Tiene como propósito fomentar la reflexión sobre la relación entre las dimensiones disciplinar y de formación del profesional de servicios humanos en Terapia Física, Terapia Ocupacional y Terapia del Lenguaje, de acuerdo a una concepción humanista.

  2. Reflexiones humanistas sobre conocimiento y servicios en terapia física, terapia ocupacional y terapia del lenguaje

    Directory of Open Access Journals (Sweden)

    Marie Luise H. de Alvarado

    1986-07-01

    Full Text Available Este artículo constituyó la ponencia central del XX Aniversario de las Carreras de Terapia Física, Terapia Ocupacional y Terapia del Lenguaje en la Universidad Nacional de Colombia, celebrado en marzo de 1986. Tiene como propósito fomentar la reflexión sobre la relación entre las dimensiones disciplinar y de formación del profesional de servicios humanos en Terapia Física, Terapia Ocupacional y Terapia del Lenguaje, de acuerdo a una concepción humanista.

  3. La terapia breve: una alternativa de intervención psicológica efectiva

    Directory of Open Access Journals (Sweden)

    Nohelia Hewitt Ramírez

    2009-10-01

    Full Text Available El objetivo de este trabajo es describir y estructurar los orígenes, bases teóricas y los procedimientos de la terapia breve desde la perspectiva terapéutica cognitivo conductual. Se inicia con la identificación de las bases teóricas de la terapia breve, principalmente las teorías motivacionales relacionadas con la disponibilidad al cambio y la autoeficacia desde la teoría social cognitiva. Se realiza un paralelo entre las características principales de la terapia breve en contraposición con las terapias tradicionales. Por último, se propone una estructura procedimental general de estrategias clínicas a emplear en la terapia breve con soporte empírico, la cual puede ser utilizada en diferentes problemáticas con variaciones específicas de acuerdo con el problema tratado o las características específicas del consultante.

  4. La terapia breve: una alternativa de intervención psicológica efectiva

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Gantiva Díaz

    2009-06-01

    Full Text Available El objetivo de este trabajo es describir y estructurar los orígenes, bases teóricas y los procedimientos de la terapia breve desde la perspectiva terapéutica cognitivo conductual. Se inicia con la identifi cación de las bases teóricas de la terapia breve, principalmente las teorías motivacionales relacionadas con la disponibilidad al cambio y la autoefi cacia desde la teoría social cognitiva. Se realiza un paralelo entre las características principales de la terapia breve en contraposición con las terapias tradicionales. Por último, se propone una estructura procedimental general de estrategias clínicas a emplear en la terapia breve con soporte empírico, la cual puede ser utilizada en diferentes problemáticas con variaciones específi cas de acuerdo con el problema tratado o las características específi cas del consultante

  5. Efectividad de la terapia cognitivo-conductual en la pérdida de peso tras dos años de cirugía bariátrica en pacientes con obesidad mórbida

    OpenAIRE

    V Abilés; J Abilés; S Rodríguez-Ruiz; V Luna; F Martín; N Gándara; MC Fernández-Santaella

    2013-01-01

    Objetivo: Evaluar la efectividad de la Terapia Cognitivo Conductual (TCC) en el éxito de la pérdida de peso postoperatoria tras 2 años de CB. Metodología: Estudio observacional prospectivo en el que se incluyeron pacientes entre 18 y 59 años candidatos a CB, entre enero de 2007 y junio de 2010, realizando seguimiento postoperatorio hasta junio de 2012. Se compararon dos grupos de estudio de acuerdo a su participación en TCC o no. Se tomaron datos de peso corporal y estatura, a partir de las c...

  6. Adherencia de planes caseros de terapia respiratoria en pacientes con enfermedades crónicas del programa de atención domiciliaria, Cali, 2014 / Adherence to home respiratory therapy plans among patients with chronic diseases from the home care program, Cali, 2014

    Directory of Open Access Journals (Sweden)

    Anisbed Naranjo-Rojas

    2016-05-01

    Full Text Available Resumen Objetivo: Determinar la adherencia de los planes caseros de terapia respiratoria en pacientes con enfermedades crónicas de un programa de atención domiciliaria, cuyos tratamientos incluyen prácticas de terapias respiratorias en la ciudad de Santiago de Cali – Colombia. Metodología: Se realizó un estudio observacional, descriptivo y de corte transversal. La población de estudio correspondió a 83 adultos entre 45 y 85 años con patologías crónicas, no alterara las funciones cognitivas, pertenecientes al programa de terapia respiratoria de la ips sisanar. Se diseñó una encuesta dirigida al paciente y cuidadores primarios. Resultados: El comportamiento entre las variables analizadas no fue paralelo, en ambas variables bien sea por factores como el tipo de afiliación, caso que correspondería al Plan casero Vs sgsss, mientras que el segundo de ellos presenta un comportamiento que refleja una diferencia en el número de sesiones realizadas por mes y las actividades registradas en el plan casero. Discusión: Este estudio encontró que los planes caseros muestran que la adherencia es efectiva pero depende del alto grado del manejo que se dé inicialmente desde los Sistemas de Seguridad Social al que pertenezcan los pacientes y al cumplimiento de las actividades. / Abstract Objective: to assess the adherence to home respiratory therapy plans in patients with chronic diseases from a home care program whose treatments include respiratory therapy practice in the city of Santiago de Cali, Colombia. This study focused mainly on the patients affiliated to the home care program of the SISANAR health care providing institution. Methodology: an observational, descriptive and cross-sectional study was conducted. The studied population consisted of 83 adults aged 45 to 85 with chronic pathologies which did not alter cognitive functions. These patients were part of the respiratory therapy program of the SISANAR health care providing institution

  7. Tratamiento de heridas complejas con terapia de presión negativa: Experiencia en los últimos 6 años en la Clínica Universitaria de Navarra, Pamplona (España Complex wound management with vacuum assisted therapy: Experience in the past 6 years at the University Clinic of Navarra, Pamplona (Spain

    Directory of Open Access Journals (Sweden)

    J. Buendía Pérez

    2011-12-01

    Full Text Available El empleo de la terapia de presión negativa es una opción ampliamente extendida dentro del campo de la Cirugía Plástica. Desde su aparición en el mercado se han ido sumando indicaciones de tratamiento de diversa índole, como podemos ver reflejado en la bibliografía existente al respecto. El sistema VAC® promueve la curación de las heridas mediante la aplicación de presión negativa, de manera que el uso de niveles controlados de presión subatmosférica y succión controlada, acelera la resolución de las mismas favoreciendo la vascularización y el desbridamiento. Actualmente, este sistema se considera un arma fundamental en el tratamiento de las heridas complejas, las cuales suponen un reto terapéutico importante y muchas veces acarrean a los pacientes que las padecen un largo y costoso ingreso hospitalario. Gracias a la terapia de vacío se puede disminuir el tamaño de dichas heridas a la par que se protegen de la infección, haciendo innecesario el uso prioritario de colgajos libres y grandes intervenciones. Presentamos una revisión de casos de interés sobre nuestra experiencia clínica con el uso de terapia de vacío en los últimos 6 años, durante la etapa comprendida entre mayo del 2005 y noviembre del 2011, con un total de 41 pacientes.The vacuum-assisted closure or negative pressure wound therapy is a widespread therapeutic option in Plastic Surgery. Since its first application several indications have been suggested for treatment of difficult wounds. The VAC® therapy system promotes wound healing through the application of negative pressure by controlled suction which, accelerate the resolution of different kinds of wound by promoting vascularization and debridement. It is currently considered as a useful tool in the treatment of complex wounds. These injuries represent a therapeutic challenge for the plastic surgeon that often involve a lengthy and costly hospitalization. Thanks to the VAC® therapy the size of these

  8. Fallout and drinking water contamination by I-131 and Cs-134, 137 in Japan, from the Fukushima Daiichi NPS accident

    International Nuclear Information System (INIS)

    Kelecom, Alphonse; Miyashita, Erika; Kelecom, Patrick Vicent

    2011-01-01

    The earthquake followed by a tsunami in Japan, on last March 11, seriously damaged four of the six reactors of the Fukushima Daiichi nuclear power station (NPS). Radioactive smokes and highly contaminated water were released for weeks to the environment. Since March 12, when the plant operator TEPCO and Japan's nuclear agency (NISA) confirmed the presence of radionuclides near the NPS, a giant environmental monitoring operation was set up, covering the entire Japanese territory. Daily thousands measurements are realized. We here analyze data released during 60 days on I-131 and Cs-134,137 radioactive concentrations in drinking water and fallout for 45 prefectures. Miyagi and Fukushima, that requires a separate study, are not considered here. Drinking water contamination by I-131 was observed in 13 prefectures, including Tokyo. The most impacted one was Tochigi (maximum of 110 Bq/l, March 24). This value turned water not drinkable for infants and babies. Cs-137 was detected in drinking water in 8 prefectures, with a maximum level of 18 Bq/l in Ibaraki. These levels do not affect potability of tap water. I-131 was observed in fallout in 27 prefectures, with level reaching 93 kBq/m2 in Ibaraki and 36 kBq/m 2 in Tokyo on March 21 and 23 respectively. Fallout of Cs-137 was observed in 19 prefectures. The maximum deposition occurred again in Ibaraki (13kBq/m 2 , March 21) and in Tokyo (5.3 kBq/m2, March 22). Since mid April, only trace contamination has been observed for both radionuclides in drinking water. Sporadically medium levels of Cs-137 are still observed in fallout. (author)

  9. Fallout and drinking water contamination by I-131 and Cs-134, 137 in Japan, from the Fukushima Daiichi NPS accident

    Energy Technology Data Exchange (ETDEWEB)

    Kelecom, Alphonse; Miyashita, Erika; Kelecom, Patrick Vicent [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil)

    2011-07-01

    The earthquake followed by a tsunami in Japan, on last March 11, seriously damaged four of the six reactors of the Fukushima Daiichi nuclear power station (NPS). Radioactive smokes and highly contaminated water were released for weeks to the environment. Since March 12, when the plant operator TEPCO and Japan's nuclear agency (NISA) confirmed the presence of radionuclides near the NPS, a giant environmental monitoring operation was set up, covering the entire Japanese territory. Daily thousands measurements are realized. We here analyze data released during 60 days on I-131 and Cs-134,137 radioactive concentrations in drinking water and fallout for 45 prefectures. Miyagi and Fukushima, that requires a separate study, are not considered here. Drinking water contamination by I-131 was observed in 13 prefectures, including Tokyo. The most impacted one was Tochigi (maximum of 110 Bq/l, March 24). This value turned water not drinkable for infants and babies. Cs-137 was detected in drinking water in 8 prefectures, with a maximum level of 18 Bq/l in Ibaraki. These levels do not affect potability of tap water. I-131 was observed in fallout in 27 prefectures, with level reaching 93 kBq/m2 in Ibaraki and 36 kBq/m{sup 2} in Tokyo on March 21 and 23 respectively. Fallout of Cs-137 was observed in 19 prefectures. The maximum deposition occurred again in Ibaraki (13kBq/m{sup 2}, March 21) and in Tokyo (5.3 kBq/m2, March 22). Since mid April, only trace contamination has been observed for both radionuclides in drinking water. Sporadically medium levels of Cs-137 are still observed in fallout. (author)

  10. Outcomes of pregnancy in function of radiation dose to ovaries following a treatment with I131 for a differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Garsi, J.P.; Rubino, C.; Labbe, M.; Vathaire, F. de; Garsi, J.P.; Schlumberger, M.; Rubino, C.; Ricard, M.; Labbe, M.; Vathaire, F. de; Garsi, J.P.; Rubino, C.; Labbe, M.; Vathaire, F. de; Schvartz, C.; Henri-Amar, M.; Bardet, S.; Ceccarelli, C.

    2008-01-01

    Radiations are mutagen. During a treatment for a differentiated cancer of thyroid, the minimal activity of I 131 given to the patient is 3700 MBq producing a radiation dose to ovaries estimated to 140 mGy. In spite of the importance of this dose, few data on the outcomes of the pregnancy after irradiation are available. After our study it appears that the exposure to I 131 has no harmful effect on the outcomes of these pregnancies. (N.C.)

  11. Estimation of parameters biokinetics from the resolution of a model compartment for I-131. Application to a patient with thyroid carcinoma hemodialysis

    International Nuclear Information System (INIS)

    Garcia, R.; Jimenez Feltstrom, D.; Luis dimon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.

    2013-01-01

    This work aims to define a biokinetic model for the I-131, and solve it for different conditions of the patient or person affected (normal, with cancer of the thyroid or hyperthyroid). Solve the model in the case of a patient treated with I-131 for ablation of thyroid remnants with undergoing renal insufficiency and hemodialysis . Get the parameters Biokinetic this model for different situations. (Author)

  12. Evaluation of absorbed dosis during studies of renal function due AI 123I / 131I (Hippuran) and 111 In (DPTA)

    International Nuclear Information System (INIS)

    Arteaga, Marcial V.V.; Diestra, Carlos E.C.; Villanueva, Raul A.S.; Alegria, Roberto R.; Salvatierra, Carlos C.; Rosales, Jorge M.; Gonzalez, Denis A.; Cruz, Carlos A.M.

    2014-01-01

    Using the MIRD methodology and Cristy-Eckerman representation for for adult kidneys, it proves that the dosimetric contributions of bodies of the biokinetics of 123 I / 131 I (Hippuran) and 111 In (DTPA) are significant, in the estimated of dose, during studies of renal function. Dosimetric contributions (whole body and urinary bladder, kidney excluding) are given by 11.90% (for 123 I), 4.97% (for 131 I) and 28.32% (for 111 In). In all cases, the dosimetric contributions are mainly due to photons emitted by the entire body

  13. Our first experience in the application of I-131 MIBG in a patient with neuroblastoma (A case report)

    International Nuclear Information System (INIS)

    Samarina, G.; Poksi, A.

    2005-01-01

    Full text: Neuroblastomas (NB) belong to a group of neuroendocrine tumors that are thought to arise from cells in the neural crest from the pelvis to neck, produce high levels of the urinary catecholamines vanillylmandelic acid (VMA) or homovanillic acid (HVA) in more than 90% of cases, and often metastasize to bones, bone marrow (BM), lymph nodes, and the liver. I-123 MIBG and I-131 MIBG are clinically important radiopharmaceuticals, which are routinely used for diagnostic imaging and treatment of NB. 90% percent of NB takes up the MIBG. If, however, the MIBG cannot successfully attach to a patient's tumor, it cannot be used to find or treat it. A 20-month-old girl presented with a 6-month history of a rapidly growing tumor mass 3.5 cm in diameter in the left orbital region. The first CT scan revealed a soft tissue tumor 22 x 28 mm, extending from the inferolateral wall of the left orbit and destroying the surrounding bone (os zygomaticus). CT scans of the chest and abdomen were negative. Histopathology showed high malignancy (G3) of NB (immunohistochemical reactions: NSE positive, CgA positive, SY positive, Ki-67 70% of tumor cells positive). First BM histological examination revealed no pathological findings. Urinary VMA and HVA levels were within the normal range. Tc-99m MDP scans showed increased uptake of radiopharmaceutical in the bones around the left orbital region but no evidence of skeletal metastases. 123 I-MIBG studies revealed a hypermetabolic focus in the left orbital region, concordance with the CT and bone scans. The child was treated with preoperative chemotherapy, but without any results: the CT-scan performed four months later showed that the tumor had grown to 45 x 37 x 40 mm. The clinical test demonstrated the progress of the disease and the tumor at that stage was inoperable. Clinicians decided to change the chemotherapy regimen and a CT study carried out three months later showed that the tumor had decreased to 26 x 10 x 30 mm. The patient

  14. Efecto de la terapia UVB de banda estrecha sobre la síntesis de vitamina D y los parámetros de síndrome metabólico en pacientes con psoriasis moderada y grave

    OpenAIRE

    Romaní de Gabriel, Jorge

    2013-01-01

    La psoriasis es una enfermedad cutánea crónica que ha sido relacionada con el síndrome metabólico. El objetivo de este trabajo fue evaluar en pacientes con psoriasis la presencia de alteraciones en parámetros antropométricos y marcadores séricos relacionados con el síndrome metabólico, y su modificación tras un tratamiento con ultravioleta B de banda estrecha. Comparamos a 50 pacientes con psoriasis con 50 controles emparejados por sus características antropométricas (edad, sexo e índice de m...

  15. Terapia sistémica de pareja en la depresión: un estudio de caso único

    OpenAIRE

    Feixas i Viaplana, Guillem; Muñoz Cano, Dámaris; Dada Sánchez, Gloria; Compañ, Victoria; Arroyo Andreu, Susana

    2009-01-01

    En este estudio de caso único se presenta el tratamiento de una mujer diagnosticada de depresión mayor con terapia sistémica de pareja. Esta modalidad de terapia supone la inclusión de la pareja en todas las sesiones de tratamiento, en las que se trabaja con ambos de forma conjunta. A medida que avanza la terapia se van explicitando los significados relacionales de los síntomas y las dificultades de relación, y se trabaja de forma conjunta para remediarlas. El proceso terapéutico se completó ...

  16. Terapias naturales cuerpo - mente

    OpenAIRE

    Vesga Sanchez, Beatriz Amparo

    2016-01-01

    Plantea la visi?n desde la perspectiva hol?stica, de c?mo funciona el cuerpo y la mente, como nos afectan las emociones en los procesos de armonia y b?squeda del equilibrio para la sanacion f?sica, mental y espiritual. Se hace un recorrido por la medicina tradicional china con el concepto de los meridianos, la medicina ayurvedica con el concepto de los centros energ?ticos o chakras y las culturas andinas.

  17. Radiation Dose to Family Member of Hospitalized Patient Receiving I-131 Therapy for Thyroid Cancer: Case Study

    International Nuclear Information System (INIS)

    Tuntawiroon, M; Chaudakshetrin, P; Sritongkul N; Thongprapal, T

    2009-07-01

    Full text: During high-dose I-131 therapy, hospitalized patient who is unable to walk to the bathroom is at risk of radiation burden to comforter from excreted urine. Foley catheter is usually placed in the patient before I-131 administration. The urine was collected and housed in lead shielding, emptied every 4 to 6 hours on the first day, and every 8 to 10 hours on subsequent days. After specific instructions with regard to radiation safety, family member designed as the caregiver of patient was provided an electronic personal dosimeter to directly measure radiation dose for three days in isolated hospitalization and two more weeks at home. The caregiver recorded time spent in contact with the patient and activities performed during these times. Total accumulative dose for 16 days was 650 μSv of which 44% (288 μSv) was from the first 24 hours and more than 70% (462 μSv) during the first 72 hours, and about 25% (162 μSv) from emptying urine bags. Most of the dose received (488 μSv) was from attending time spent in the vicinity of the patients. However, this was not exceeding the constraints of 1 mSv/y and well below the limit of 5 mSv in any one year for exposed caregiver and comforter

  18. Evaluation of detectors for blood bioanalysis in Lu-177 and I-131 therapies for bone marrow dosimetry

    International Nuclear Information System (INIS)

    Degenhardt, Amilie Louize

    2016-01-01

    The measures traceability is mandatory for minimizing uncertainties in internal dosimetry for radiopharmaceuticals clinical studies and ensures the quality of the standard. Equipment should have resolution and efficiency compatible with radionuclides energies and, additionally, be able to quantify variations in human bodies' activities samples since the initial administration near the minimum residual activities. For testing three equipment (ionization chamber Capintec 25R, sodium iodine scintillator LTI Genesys Gamma-1 and high hyperpure germanium detector Canberra), they were prepared Lu-177 and I-131 radiation sources simulating patient's blood samples activities by adopting the following hypothesis: (1) initial activities according the Brazilian protocols; (2) blood volume in the whole body (5.3 L for adult men and 1.4 L for 5 years-old children); (3) effective half-lives (1.61 h and 42.9 h for Lu-177 bi-exponential adjustment and 15.7 h for I-131 mono-exponential adjustment); (4) sampling between 30 min and 168 h; (v) blood density adjustments. The standard sources were measured in the secondary standard ionization chamber Centronics IG11 at the Laboratorio Nacional de Metrologia das Radiacoes Ionizantes. The Capintec ionization chamber efficiencies ranged, respectively for I-131 and Lu-177, between (111.58±0.02)% and (102.27±0.01)% and HPGe semiconductor detector efficiencies ranged, respectively, between (89.40±0.03)% and (87.80±0.04)%. For the NaI detector, when the Lu-177 sources were positioned inside the detector the efficiencies ranged between (12.66±0.01)% and (11.54± 0.07)% and when the sources were positioned at 5 cm and 10 cm from the detector the efficiencies decreased to less than 5%. For I-131 sources positioned inside the detector, the efficiencies ranged between (29.76±0.21)% and (30.20±0.04)% and they decreased to less than 5% when they were positioned at 5 cm and 10 cm from the detector (deviation greater than 95

  19. Comparación de la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica en dos vías de implatación Comparison of efficacy and safety of combined therapy of cellular cardiomyoplasty and granulocyte colony stimulating factor in patients with ischemic cardiomyopathy in two routes of implantation

    Directory of Open Access Journals (Sweden)

    Juan M Senior

    2011-04-01

    Full Text Available Este estudio tiene como objetivo evaluar la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica, y explorar posibles diferencias entre la vía de implantación. METODOLOGÍA: se hizo un estudio de «antes y después» para datos longitudinales en el que se compararon variables ecocardiográficas y número de MET alcanzados en la prueba de esfuerzo antes, dos, seis y doce meses después del procedimiento; así mismo, se evaluaron la mortalidad y los efectos adversos de la terapia. Se exploraron diferencias en los resultados de acuerdo con la vía de implantación intracoronaria vs. epicárdica. RESULTADOS: se incluyeron dieciocho pacientes, 62,3% hombres, cuya edad promedio fue 49,4 ± 11,7 años y la fracción de eyección promedio fue 31% ± 0,04. La implantación se realizó por vía intracoronaria en doce pacientes y por vía epicárdica en seis. La mediana de fracción de eyección antes de la implantación de las células fue de 30% con un rango intercuartil de 28%-35% y la media de los MET fue de 6 con un rango intercuartil de 5-7; ambas variables, al igual que los volúmenes ventriculares de fin de diástole y sístole se incrementaron de forma significativa después del procedimiento, con tendencia a un mayor incremento de la fracción de eyección en el grupo de pacientes cuya vía de implantación fue la epicárdica en comparación con la vía intracoronaria; sin embargo, el número de pacientes en cada subgrupo impidió hacer análisis definitivos. Un paciente tuvo infección de la herida quirúrgica y tres murieron dos meses después de la implantación (uno de shock séptico y dos de shock cardiogénico. CONCLUSIÓN: en nuestro medio es factible realizar terapia combinada con cardiomioplastia celular y factor estimulante de colonias de granulocito; este es un procedimiento seguro con el que se obtiene una mejor

  20. Dosimetric comparison fixed-individualized activity in the treatment of serious disease with I -131; Comparacion dosimetrica actividad fija-actividad individualizada en el tratamiento de la enfermedad de graves con I-131

    Energy Technology Data Exchange (ETDEWEB)

    Melgar Perez, J.; Orellana Salas, A.; Santaella, Y.; Arrocha Acevedo, J. F.

    2013-07-01

    The iodine-131 therapy has become the treatment with radiopharmaceuticals more frequent in our country, as well as the largest source of exposure to ionizing radiation for members who surround the patient. The aim of this article is to analyse the recommendations of radiological protection which are delivered to the patient receiving radiation discharge, in terms of the duration of the same time, taking into account the radiopharmaceutical dose, the time of entry, the dose rate measured at one meter and the family environment among others. (Author)

  1. Dosimetric calculation of I-131 activity for the treatment to patients having differentiated thyroid cancer. Benefits and limitations; Calculo dosimetrico de la actividad de I-131 para tratamiento de pacientes con cancer diferenciado de tiroides (CADT). Beneficios y limitaciones

    Energy Technology Data Exchange (ETDEWEB)

    Cabrejas, R. C.; Chebel, G. M.; Fadel, A. M.; Rojo, A. M.; Deluca, G.; Degross, O. J.; Valdivieso, C. M.; Carbejas, M. L.

    2006-07-01

    Maximum safe activity calculation, that has to be administered for treatment to patients having Differentiated Thyroid Cancer (CADT). No important side effects should be produced. Post treatment evolution was analysed. 23 Dosimetric studies were performed determining blood and whole body uptake curves (CE)during 5 days. Using the MIRDOSE software, the maximum safe activity in the whole body (CE)was calculated. The retained activity in the body (AR), 48 hs. post tracer dose. Should have been less than 2.96 GBq so as to avoid lung fibrosis. 17 patients that received activities<11.1 GBq, had no side effects. Three patients presents special situations: high AR, users in the mouth, and plaque to and leucopenia. This methodology has benefits because AT can be estimated. This was possible for 85% of the patients. When AR was high at 48 hr, AT was diminished to avoid pulmonary lesions. Tumor absorbed dose estimation, will allow the administration of AT>11.1 GBq in the future. (Author)

  2. Study on the change of hepatic fibrosis indicators in serum before and after I-131 treatment in Graves' Patients

    International Nuclear Information System (INIS)

    Li, L.

    2007-01-01

    Full text: Objective: To explore the change of hepatic fibrosis indicators, i.e., PC-III (type III procollagen), IV-C (type IV collagen), HA (hyaluronic acid), LN (laminin) levels in serum of Graves' patients before and after I-131 treatment. Methods: Control group were 40 healthy cases (female 25, male 15, aged 18-60 years) with normal serum levels of those indicators by medical examination in our hospital. Fifty-five Graves' patients (female 32, male 23, aged 17-58) were diagnosed by thyroid function indicators (TT3, TT4, FT3, FT4, TSH) tests, thyroid iodine intake and clinical symptoms and signs, with normal hepatic function indicators and without combined history of hepatic disease, cardiac disease, diabetes, and rheumatic disease. Three to six months after I-131 treatment these were completely recovered (back to normal thyroid function, shrunken thyroid gland volume from swelling, and disappeared clinical symptoms and signs). In both controls and Graves' patients, 2 ml venous blood was taken at early morning from each case with limosis respectively before and after I- 131 treatment. RIA method was adopted for detection of each serum indicator with reagents kit. Data were analyzed by t test in the SPSS statistical software pack. Results: 1. In Graves' patients, before treatment PC- III (type III procollagen) levels were statistically higher than that in controls (p 0.05). 2. In Graves' patients, PC-III significantly decreased to a lower level after treatment than before (p 05). 3. In Graves' patients, after treatment there is no significant difference of indicator levels when compared with controls (p>0.05). Conclusion: Graves' patients had certain degree of hyperplasia of hepatic connective tissue, and this pathogenesis recovered with healing of Graves' disease. PC-III positive rate and thyroid function indicator positive rate may be better in accordance with the disease process than IV-C, Ha and LN indicators. These data showed that of four serum hepatic

  3. Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid. A comparison of ablation success with different activities of radioiodine (I-131)

    International Nuclear Information System (INIS)

    Prpic, M.; Dabelic, N.; Stanicic, J.; Jukic, T.; Kusic, Z.; Milosevic, M.

    2012-01-01

    The objective of this study was to assess efficiency of various I-131 activities on thyroid remnant ablation in thyroid cancer patients. The significance of patients' characteristics, pathologic features and levels of Tg were analyzed. This study included 259 consecutive differentiated thyroid cancer patients, with disease confined to the thyroid, treated with I-131 after total thyroidectomy. Patients were divided into the three groups: 80 patients receiving low [1110-1850 MBq (30-50 mCi)], 121 intermediate [2775 MBq (75 mCi)] and 58 high [3700 MBq (100 mCi)] postoperative I-131 activities. Six to eight months after the application of radioiodine, measurements of TSH, Tg, anti-Tg antibodies (in hypothyroid state) together with ultrasound exam and whole-body scintigraphy were performed. The ablation was significantly more effective (after the first application) in patients receiving 100 mCi of I-131-89.7% than in patients receiving lower activities (P=0.016). There was no significant difference in ablation rate between the 30-50 mCi (77.5%) and 75 mCi (70.2%) groups. In the group receiving 30-50 mCi, patients with solitary tumors had significantly higher ablation rate (P=0.038). In patients receiving 75 mCi ablation rates were higher among older patients (P=0.005), with infiltration of the single lobe (P=0.005), and with solitary tumor (P=0.012). The rates of successful ablation after the second application of I-131 (after 12-16 months) amounted to 96, 97 and 96% in the 30-50, 75 and 100 mCi groups, respectively. The activity of I-131 and age were independent factors for thyroid ablation failure after the first application of I-131 (model of binary logistic regression). The results of remnant ablation were satisfactory with all activities applied. Although after the first application of I-131 the activity of 100 mCi is significantly more effective in thyroid ablation than the administration of 30-50 mCi and 75 mCi, the ablation rates between all the three groups are

  4. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  5. Experiencia de la terapia con lokomat en pacientes portadores de parálisis cerebral y síndromes atáxicos, instituto de rehabilitación infantil teletón concepción Chile

    Directory of Open Access Journals (Sweden)

    D. Lorena Llorente, DRA.

    2014-03-01

    En el Instituto de Rehabilitación Infantil Teletón Concepción el Lokomat existe desde 2008. Esto ha permitido recoger experiencias relacionadas con los cambios observados en el desempeño de la marcha de niños con distintos trastornos de la marcha de origen neurológico tratados con esta órtesis robótica. Se presentan resultados preliminares de tres líneas de investigación que se están desarrollando actualmente incluyendo niños con Parálisis Cerebral Hemipléjica, Parálisis Cerebral dipléjica y con Síndromes Atáxicos.

  6. Model of iodine metabolism in a T3-thyrotoxic patient undergoing I-131 therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ahuja, S.; Price, R.; Brill, A. B.; Dobyns, B. M.; Berman, M.

    1975-06-01

    Data on radioactivity in the thyroid, urine, serum, butanol-extractable iodine (BEI) and chromatographic fractionations of BEI, obtained during four I-131 therapeutic treatments of a T3-thyrotoxic patient, have been analyzed and simulated with the help of a 7-compartment model. Good fits to most of the data can be obtained with both the dose-independent and dose-dependent models. A model with 3 or 4 compartments, which provides adequate fits to iodine kinetic data in most euthyroid and hyperthyroid patients is not satisfactory in the case of this patient. Thus, to represent iodine metabolism during T3-thyrotoxicosis therapy, we find that it is necessary to provide for separate biochemical pathways for the BEI components as well as the butanol-insoluble compounds released by the thyroid gland. (auth)

  7. Reproductive function and biological dosimetry prospective study of young thyroid differentiated cancer patients treated with I-131

    International Nuclear Information System (INIS)

    Di Giorgio, M.; Vallerga, M.B.; Taja, M.R.; Radl, A.; Chebel, Graciela; Fadel, Ana Maria; Gutierrez, Silvia; Normandi, Eduardo; Levalle, Oscar; Kundt, Miriam

    2011-01-01

    The administration of I-131 in the management of differentiated thyroid cancer (DTC) is a well established practice. As the spermatogonia is highly sensitive to radiation, large doses of internal radiation could result in adverse effects on reproductive function such as oligo/azoospermia and infertility. During spermiogenesis, mammalian chromatin undergoes replacement of nuclear histones by protamines, which yields a DNA sixfold more highly condensed in spermatozoa than in mitotic chromosomes. The structure of this highly packaged chromatin shows a low binding capacity for several fluorochromes and dyes such as chromomycin A3 (CMA3). The aim of this study is to assess the correlation between reproductive function (endocrine and exocrine testicular function, and levels of CMA3 stainability) and biological dosimetry in a prospective study of 4 young DTC patients treated with I-131. In this context, a background level of CMA3 binding in mature human sperm was established. It revealed a variable accessibility of CMA3 to the DNA that is dependant on packaging quality and thus, indicative of protamine deficiency. The identification of altered stainability suggests DNA damage as well as epigenetic effects, which may be indicators of male infertility. Transient impairment of spermatogenesis associated with an increase in FSH, an altered spermiogram and even azoospermia was observed after the administration of cumulative activities. Overall, testosterone levels were preserved, except in one case, which presented a drastically diminished value associated with an increase in LH level. As peripheral blood lymphocytes and spermatogonia have equivalent radiosensitivity (interphase death) we hypothesize that the knowledge of DNA damage recovery in peripheral lymphocytes could correlate with spermatogonia recovery and with FSH evolution. (authors)

  8. Reproductive function and biological dosimetry prospective study of young thyroid differentiated cancer patients treated with I-131

    International Nuclear Information System (INIS)

    Di Giorgio, Marina; Vallerga, Maria B.; Taja, Maria R.; Radl, Analia; Chebel, Graciela; Fadel, Ana M.; Gutierrez, Silvia; Normandi, Eduardo; Levalle, Oscar; Kundt, Miriam

    2008-01-01

    Full text: The administration of I-131 in the management of differentiated thyroid cancer (DTC) is a well established practice. As the spermatogonia is highly sensitive to radiation, large doses of internal radiation could result in adverse effects on reproductive function such as oligo/azoospermia and infertility. During spermiogenesis, mammalian chromatin undergoes replacement of nuclear histones by protamines, which yields a DNA sixfold more highly condensed in spermatozoa than in mitotic chromosomes. The structure of this highly packaged chromatin shows a low binding capacity for several fluoro chromes and dyes such as chromo mycin A 3 (CMA 3 ). The aim of this study is to assess the correlation between reproductive function (endocrine and exocrine testicular function, and levels of CMA 3 stainability) and biological dosimetry in a prospective study of 4 young DTC patients treated with I-131. In this context, a background level of CMA 3 binding in mature human sperm was established. It revealed a variable accessibility of CMA 3 to the DNA that is dependant on packaging quality and thus, indicative of protamine deficiency. The identification of altered stainability suggests DNA damage as well as epigenetic effects, which may be indicators of male infertility. Transient impairment of spermatogenesis associated with an increase in FSH, an altered spermiogram and even azoospermia was observed after the administration of cumulative activities. Overall, testosterone levels were preserved, except in one case, which presented a drastically diminished value associated with an increase in LH level. As peripheral blood lymphocytes and spermatogonia have equivalent radiosensitivity (interphase death) we hypothesize that the knowledge of DNA damage recovery in peripheral lymphocytes could correlate with spermatogonia recovery and with FSH evolution. Therefore, a prospective study on the decline of unstable chromosome aberrations is being conducted, considering the damage

  9. Proceso de Cambio Psicoterapéutico: Análisis de Episodios Relevantes en una Terapia Grupal con Pacientes Adictos Therapeutic Change Process: Analysis of Relevant Episodes in a Group Therapy With Addict Patients

    Directory of Open Access Journals (Sweden)

    Nelson Valdés

    2005-11-01

    Full Text Available En el presente artículo se presentan los resultados de una investigación que tuvo como objetivo determinar y describir el tipo de acciones comunicacionales realizadas por terapeutas y pacientes durante las sesiones de una terapia grupal. Para esto se utilizó una metodología orientada al descubrimiento empleando un análisis cualitativo de contenido. En los resultados se incluye tanto la descripción de las acciones identificadas de acuerdo al nivel de análisis, así como los patrones ideales de secuencia de dichos componentes asociados al cambio y propios de esta modalidad terapéutica. Finalmente, los resultados son discutidos considerando los principales antecedentes teóricos y empíricos en materia de investigación en psicoterapia.This article presents the results of a study aimed to determine and describe the type of communicative actions made by therapists and patients during the sessions of a group therapy. A discovery-oriented methodology was applied, conducting qualitative content analysis. Results include the description of the identified actions by levels of analysis, and their ideal sequential patterns, associated to in-session change and particularly to this therapeutic modality. Finally, the results are discussed considering the main theoretical and empirical frameworks in psychotherapy research.

  10. RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with I-131 radiation dose and other characteristics

    Science.gov (United States)

    Leeman-Neill, Rebecca J.; Brenner, Alina V.; Little, Mark P.; Bogdanova, Tetiana I.; Hatch, Maureen; Zurnadzy, Liudmyla Y.; Mabuchi, Kiyohiko; Tronko, Mykola D.; Nikiforov, Yuri E.

    2012-01-01

    Background Childhood exposure to I-131 from the 1986 Chernobyl accident led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited. Methods We performed mutational analysis of 62 PTCs diagnosed in a Ukrainian cohort of patients who were Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with I-131 dose and other factors. These data support the relationship between chromosomal rearrangements, but not point mutations, and I-131 exposure and point to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients. PMID:23436219

  11. High-dose I-131 MIBG treatment for young children with high-risk neuroblastoma, and its practical problem. From the experience of the youngest case in Japan

    International Nuclear Information System (INIS)

    Araki, Raita; Nishimura, Ryosei; Mase, Shintaro

    2012-01-01

    High-dose I-131 MIBG (metaiodobenzylguanidine) therapy combined with auto- or allo-hematopoietic stem cell transplantation is becoming a potential treatment for patients with high-risk neuroblastoma worldwide. However, only older children, who can perform personal care, had been given high-dose I-131 MIBG treatment to avoid the needless radiation exposure to caregivers and medical staff in Japan. In this case report, we have used the high dose MIBG therapy followed by autologous PBSCT (peripheral blood stem cell transplantation) for a 1-year-old boy with a newly diagnosed high-risk neuroblastoma with MYCN amplifications. The total radiation exposure to all parties involved was very limited, even in the youngest case in Japan, probably due to adequate preparations. This encouraging experience may remove the age limit for high-dose I-131 MIBG treatment for the patients with high-risk neuroblastoma in Japan. (author)

  12. Princípios de terapia génica

    OpenAIRE

    Reverter Velasco, Naiara

    2016-01-01

    Podríamos definir la terapia génica como la introducción de un gen foráneo en el ser humano con fines terapéuticos. La terapia génica comenzó a ser utilizada en el ser humano a principios de los años 90 y en los últimos años ha empezado a dar sus frutos. Se trata de un tratamiento principalmente experimental, aunque ya han comenzado a comercializarse algunos de sus productos. Este campo de la investigación ha generado y aún genera mucha controversia, generalmente por incomprensión de los prin...

  13. Daily variation of I-131, Cs-134 and Cs-137 activity concentrations in the atmosphere in Osaka during the early phase after the FDNPP accident

    International Nuclear Information System (INIS)

    Zijian Zhang; Kazuhiko Ninomiya; Naruto Takahashi; Atsushi Shinohara

    2015-01-01

    To investigate the time variations of radionuclides discharged from the Fukushima Daiichi nuclear power plants accident, we started collecting aerosol samples in Osaka, Japan, using a high-volume sampler from March 15 to May 1, 2011. Atmospheric radioactivity concentrations of I-131, Cs-134 and Cs-137 were measured with germanium semi-conductor detectors. Only I-131 was detected in the early phase and two Cs-134.137 peaks were found in Osaka in April. Using the HYSPLIT model, we concluded that direct transportation of the air mass from the Fukushima area was responsible for such events. (author)

  14. Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid

    International Nuclear Information System (INIS)

    Lamart, Stephanie; Simon, Steven L; Lee, Choonsik; Bouville, Andre; Eckerman, Keith F; Melo, Dunstana

    2011-01-01

    The S values for 11 major target organs for I-131 in the thyroid were compared for three classes of adult computational human phantoms: stylized, voxel and hybrid phantoms. In addition, we compared specific absorbed fractions (SAFs) with the thyroid as a source region over a broader photon energy range than the x- and gamma-rays of I-131. The S and SAF values were calculated for the International Commission on Radiological Protection (ICRP) reference voxel phantoms and the University of Florida (UF) hybrid phantoms by using the Monte Carlo transport method, while the S and SAF values for the Oak Ridge National Laboratory (ORNL) stylized phantoms were obtained from earlier publications. Phantoms in our calculations were for adults of both genders. The 11 target organs and tissues that were selected for the comparison of S values are brain, breast, stomach wall, small intestine wall, colon wall, heart wall, pancreas, salivary glands, thyroid, lungs and active marrow for I-131 and thyroid as a source region. The comparisons showed, in general, an underestimation of S values reported for the stylized phantoms compared to the values based on the ICRP voxel and UF hybrid phantoms and relatively good agreement between the S values obtained for the ICRP and UF phantoms. Substantial differences were observed for some organs between the three types of phantoms. For example, the small intestine wall of ICRP male phantom and heart wall of ICRP female phantom showed up to eightfold and fourfold greater S values, respectively, compared to the reported values for the ORNL phantoms. UF male and female phantoms also showed significant differences compared to the ORNL phantom, 4.0-fold greater for the small intestine wall and 3.3-fold greater for the heart wall. In our method, we directly calculated the S values without using the SAFs as commonly done. Hence, we sought to confirm the differences observed in our S values by comparing the SAFs among the phantoms with the thyroid as a

  15. Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid

    Science.gov (United States)

    Lamart, Stephanie; Bouville, Andre; Simon, Steven L.; Eckerman, Keith F.; Melo, Dunstana; Lee, Choonsik

    2011-11-01

    The S values for 11 major target organs for I-131 in the thyroid were compared for three classes of adult computational human phantoms: stylized, voxel and hybrid phantoms. In addition, we compared specific absorbed fractions (SAFs) with the thyroid as a source region over a broader photon energy range than the x- and gamma-rays of I-131. The S and SAF values were calculated for the International Commission on Radiological Protection (ICRP) reference voxel phantoms and the University of Florida (UF) hybrid phantoms by using the Monte Carlo transport method, while the S and SAF values for the Oak Ridge National Laboratory (ORNL) stylized phantoms were obtained from earlier publications. Phantoms in our calculations were for adults of both genders. The 11 target organs and tissues that were selected for the comparison of S values are brain, breast, stomach wall, small intestine wall, colon wall, heart wall, pancreas, salivary glands, thyroid, lungs and active marrow for I-131 and thyroid as a source region. The comparisons showed, in general, an underestimation of S values reported for the stylized phantoms compared to the values based on the ICRP voxel and UF hybrid phantoms and relatively good agreement between the S values obtained for the ICRP and UF phantoms. Substantial differences were observed for some organs between the three types of phantoms. For example, the small intestine wall of ICRP male phantom and heart wall of ICRP female phantom showed up to eightfold and fourfold greater S values, respectively, compared to the reported values for the ORNL phantoms. UF male and female phantoms also showed significant differences compared to the ORNL phantom, 4.0-fold greater for the small intestine wall and 3.3-fold greater for the heart wall. In our method, we directly calculated the S values without using the SAFs as commonly done. Hence, we sought to confirm the differences observed in our S values by comparing the SAFs among the phantoms with the thyroid as a

  16. Equinoterapia en niños con autismo

    OpenAIRE

    Martinez Alvernia, Carlos Francisco

    2015-01-01

    Introducción: Autismo es un trastorno del desarrollo caracterizado por compromiso en interacción social, habilidades de lenguaje, presentando rituales con estereotipias. Sin tratamientos curativos, actualmente se buscan terapias alternativas. Un incremento de la literatura científica de terapias asistidas con animales se ha evidenciado, demostrando mejoría en pacientes autistas con la equinoterapia. Objetivo: Realizar una revisión sistemática de la literatura para evaluar efectividad de la eq...

  17. Radiation exposure from liquid discharges from I-131 therapy rooms into the piping system of a hospital building

    International Nuclear Information System (INIS)

    Tuntawiroon, M.; Sritongkul, N.; Pusuwan, P.; Chaudakshetrin, P.

    2008-01-01

    Over 80% of the activity from patients undergoing radioiodine therapy for thyroid cancer is eliminated during the first three days. In our I-131 therapy unit, the number of hospitalized patients has increased from less than 200 in 2004 to more than 300 in 2006. The total amount of radio activity used is about 1,800 GBq per year, and the estimated amount excreted is calculated to be about 1,500 GBq. This results in significant volume of contaminated liquid discharges into the piping system. In this study, we monitored external dose rates in non-radiation use areas adjacent to pipeline connections in the building to ensure that the dose to non-occupational workers who reside in offices below the unit does not exceed 1 mSv per year. Exposure rates in areas adjacent to the pipeline junction connections were measured periodically from April 2006 to February 2007 five floors below the therapy unit. The measurements were made inside the wall at contact with the junction, outside the wall and in hallways at 1 meter from the wall, using a GM detector or an ionization chamber. The results were recorded in μSv/h and the dose received was estimated for members of the public. Significant increases in dose rates were detected in three floors below the unit. They were 20--30, 10--30 and 5--15 μSv/h at contact with the pipeline connections, 9--15, 10--15 and 3--5 μSv/h outside the wall, and 3--6, 4--6 and 2--5 μSv/h in hallways on floors 1, 2 and 3 respectively. After appropriate wall shielding has been provided, dose rate outside the wall was reduced to 1.4 μSv/h, and to 0.5.3 μSv/h in hallways. By using an occupancy factor 1/4 for hallways, the calculated dose now meets the public dose limits of 1 mSv per year. Therapeutic application of I-131 for the treatment of thyroid cancer generates a significant amount of contaminated liquid waste into the sewers. These wastes originate mainly from toilets, showers, wash basins and floor drains. Although waste discharges can be

  18. Papel de la terapia con cánula nasal de alto flujo en la prevención de la reintubación en pacientes de bajo riesgos

    OpenAIRE

    Colinas Fernández, Laura

    2016-01-01

    La oxigenoterapia acondicionada de alto flujo demostró reducir la insuficiencia respiratoria post-extubación y la tasa de reintubación a las 72 horas en pacientes ventilados con bajo riesgo de reintubación. El principal beneficio de estos resultados se observó en el fracaso de la extubación por causa respiratoria.

  19. Análisis de costo-efectividad en Colombia de anastrazol Vs. tamoxifeno como terapia inicial en mujeres con cáncer temprano de mama y receptor hormonal positivo

    Directory of Open Access Journals (Sweden)

    Óscar Gamboa

    2010-03-01

    Conclusiones. La utilización de anastrazol genera un costo por año libre de recaída superior al producto interno bruto per cápita de Colombia (Col$ 7’521.363 para 2007. En consecuencia, resulta recomendable para Colombia continuar con el tamoxifeno por cinco años.

  20. Hierro libre, transferrina y ferritina séricas de niños con desnutrición grave en terapia de recuperación nutricional. Turbo-Antioquia 2004

    Directory of Open Access Journals (Sweden)

    Claudia M. Velásquez R.

    2004-02-01

    Full Text Available El hierro libre contribuye a la producción de sustancias oxidativas que alteran la permeabilidad de la membrana celular y originan el edema característico del kwashiorkor (1. La OMS recomienda la suplementación con hierro para niños desnutridos, una vez recuperan el apetito.

  1. Desfibrilador automático implantado en pacientes con miocardiopatía hipertrófica: criterios de selección, evolución y predictores de terapia apropiada Automatic defibrillator implanted in patients with hypertrophic myocardiopathy: selection criteria, evolution and appropriate therapy predictors

    Directory of Open Access Journals (Sweden)

    Guillermo Mora

    Full Text Available Introducción y objetivos: la miocardiopatía hipertrófica es una enfermedad de origen genético con prevalencia de 1% al 2%. La mitad de los pacientes fallecen por muerte súbita cardiaca, la mayoría por arritmias ventriculares. Todavía no está claro a qué pacientes se les debe implantar un desfibrilador automático. El objetivo de este trabajo es describir una serie de pacientes con implante, los criterios empleados y los resultados obtenidos, así como analizar los predictores de terapia apropiada por el desfibrilador. Métodos: se incluyeron 20 pacientes que recibieron un desfibrilador de tercera generación. En todos se realizó estudio electrofisiológico y seguimiento prospectivo con registro de eventos. En 18 (90% se hizo estudio genético. Resultados: el 55% eran hombres con edad promedio de 40 [11-78] años. Seis (30% recibieron implantante por prevención secundaria y 14 (70% por prevención primaria; los últimos por presentar varios factores de riesgo. Se indujo una arritmia sostenida en 15 (75% y en 3 (15% taquicardia ventricular monomórfica sostenida. A 22 meses de seguimiento 4 (20% sufrieron terapia apropiada y 2 (10% fallecieron. La taquicardia ventricular monomórfica clínica (p=0,03 y la inducida (pIntroduction and objectives: hypertrophic myocardiopathy is a genetic entity with 1% to 2% prevalence. Half patients die of sudden cardiac death, most due to ventricular arrhythmias. There is still no clarity with regard to the patients to whom an automatic defibrillator has to be implanted. The objective of this work is to describe a series of patients with implant, the criteria used and the results obtained, as well as to analyze the predictors of appropriate therapy with the defibrillator. Methods: 20 patients that received a third generation defibrillator were included. Electrophysiological study and prospective follow-up with register of events was performed in all. Genetic study was done in 18 (90%. Results: 55% were

  2. Arte africano como punto de partida para una actividad de arte terapia

    OpenAIRE

    Vassiliadou Yiannaka, María

    2001-01-01

    La visita a una exposición de arte africano realizada con un grupo de pacientes de un Hospital Psiquiátrico sirve en este artículo para reflexionar sobre los aspectos implicados en la organización de actividades de arte terapia y sobre el problema de la accesibilidad de todos los ciudadanos a la vida cultural

  3. False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series

    Directory of Open Access Journals (Sweden)

    Zeina C. Hannoush

    2017-01-01

    Full Text Available Introduction. Although whole body scan (WBS with I-131 is a highly sensitive tool for detecting normal thyroid tissue and metastasis of differentiated thyroid cancer (DTC, it is not specific. Additional information, provided by single photon emission computed tomography combined with X-ray computed tomography (SPECT/CT and by the serum thyroglobulin level, is extremely useful for the interpretation of findings. Case Presentation. We report four cases of false positive WBS in patients with DTC: ovarian uptake corresponding to an endometrioma, scrotal uptake due to a spermatocele, rib-cage uptake due to an old fracture, and hepatic and renal uptake secondary to a granuloma and simple cyst, respectively. Conclusions. Trapping, organification, and storage of iodine are more prominent in thyroid tissue but not specific. Physiologic sodium-iodine symporter expression in other tissues explains some, but not all, of the WBS false positive cases. Other proposed etiologies are accumulation of radioiodine in inflamed organs, metabolism of radiodinated thyroid hormone, presence of radioiodine in body fluids, and contamination. In our cases nonthyroidal pathologies were suspected since the imaging findings were not corroborated by an elevated thyroglobulin level, which is considered a reliable tumor marker for most well-differentiated thyroid cancers. Clinicians should be aware of the potential pitfalls of WBS in DTC to avoid incorrect management.

  4. Personalization of restrictions and recommendations for patients heated with I-131. Experience during two years (2000-2001)

    International Nuclear Information System (INIS)

    Rivas Ballarin, M. A.; Ruiz Manzano, P.; Hernandez Vitoria, A.; Lozano Flores, F.; Ortega Pardina, P.

    2002-01-01

    The aim of this study is to set criteria for discharging patients treated with I-131, bearing in mind their familiar, social and working status according to the new Spanish legislation on radiological protection and European Guides related to the subject. A mathematical development and a normal contact pattern are proposed to calculate the period of restriction Tcr on the behaviour of the patients, so that the dose to their family friends and colleagues, both in thyroid carcinoma and hyperthyroidism, is within the dose constraints established in the European Guide Radiation Protection following iodine-131 therapy (exposures due to auto-patient or discharged in-patients) published in 1998. This systems has been applied ruing the last two years in Hospital Clinico Universitario Lozano Blesa of Zaragoza where the mean dose rate at 1 meter was 16,6 μSv/h on the day of discharge, after being in hospital for about 48 hours. Some results obtained for the three types of treatment are presented. (Author)

  5. Preoperative F-18-FDG PET for the detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma patients with negative I-131 whole body scans

    International Nuclear Information System (INIS)

    Byun, Byung Hyun; Urn, Sang Moo; Cheon, Gi Jeong; Choi, Chang Woon; Lee, Byeong Cheol; Lee, Guk Haeng; Lee, Yong Sik; Shim, Youn Sang

    2007-01-01

    We evaluated the diagnostic performance of FDG-PET for the detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma patients with negative I-131 scan. All patients had total thyroidectomy and following I-131 ablation therapy. In the follow-up period, FDG-PET showed suspected cervical lymph nodes metastases and neck dissection was performed within 3 months after FDG-PET. It had shown for all patients the negative I-131 scan within 3 months before FDG-PET or negative I-131 scan during the period of cervical lymph nodes metastases suspected on the basis of FDG-PET, CT, or ultrasonography until the latest FDG-PET. Preoperative FDG-PET results were compared with the pathologic findings of lymph nodes specimens of 19 papillary thyroid carcinoma patients. Serum Tg, TSH, and Tg antibody levels at the time of latest I-131 scan were reviewed. The size of lymph node was measured by preoperative CT or ultrasonography. In 45 cervical lymph node groups dissected, 31 lymph node groups revealed metastasis. The sensitivity and specificity of FDG-PET for metastasis were 74.2% (23 of 31) and 50.0% (7 of 14), respectively. Except for patients with elevated Tg antibody levels, all patients showed the elevated serum Tg levels than normal limits at the TSH of =30uIU/ml. 8 lesions without suspected metastatic findings on FDG-PET revealed metastasis (false negative), and none of them exceeded 8mm in size (4 to 8mm, median= 6mm). On the other hand, 23 true positive lesions on FDG-PET were variable in size (6 to 17mm, median=9mm). FDG-PET is suitable for the detection of metastatic cervical lymph nodes in patients with recurrent papillary thyroid carcinoma. However, false positive or false negative should be considered according to the size of lymph node

  6. C??lulas madre en terapia celular card??aca

    OpenAIRE

    Lobo Gonz??lez, Manuel

    2013-01-01

    La enfermedad cardiovascular, y su frecuente resultado final, el fallo card??aco del ventr??culo izquierdo, son la principal causa de morbimortalidad en los pa??ses desarrollados. La investigaci??n con c??lulas madre podr??a regenerar una variedad de c??lulas que incluye a los cardiomiocitos. Se han utilizado diferentes fuentes celulares para la terapia regenerativa card??aca, incluyendo c??lulas madre card??acas, mioblastos de m??sculo esquel??tico, c??lulas madre derivadas de la...

  7. La Terapia Familiar en el tratamiento de las adicciones

    OpenAIRE

    Marcos Sierra, Juan Antonio; Garrido Fernández, Miguel

    2009-01-01

    En este trabajo se presenta un breve recorrido histórico sobre el papel de la terapia familiar en el tratamiento de las adicciones. Siguiendo la propuesta de Rolland y Walsh (1996) se analizan con detenimiento los modelos centrados en la resolución de problemas y los modelos intergeneracionales. El objetivo básico del artículo es mostrar las aportaciones de las diferentes perspectivas y contribuir a enfoques más integradores en el tratamiento familiar de las adicciones. En esta...

  8. Terapia nutricional no diabetes gestacional

    OpenAIRE

    Padilha,Patricia de Carvalho; Sena,Ana Beatriz; Nogueira,Jamile Lima; Araújo,Roberta Pimenta da Silva; Alves,Priscila Dutra; Accioly,Elizabeth; Saunders,Cláudia

    2010-01-01

    Trata-se de uma revisão da literatura científica sobre a terapia nutricional no Diabetes Mellitus Gestacional, sem restrição de data e com fontes primárias indexadas nas bases de dados SciELO, PubMed, Medline. Os resultados desta revisão apontam a intervenção nutricional como uma importante aliada no controle do Diabetes Mellitus Gestacional, trazendo potenciais benefícios à saúde materno-fetal. Na avaliação do estado nutricional materno devem ser empregados os indicadores antropométricos, di...

  9. Estudio sobre efectos del programa SADL (Stimulation Activities of Daily Living) de terapia ocupacional sobre el nivel de autonomía en las actividades de la vida diaria de personas con demencia institucionalizados

    OpenAIRE

    Jiménez Palomares, María

    2014-01-01

    La demencia afecta las habilidades cognitivas, altera la conducta y produce una pérdida progresiva de la funcionalidad. El deterioro cognitivo se expresa normalmente en una disminución de las habilidades requeridas para un correcto desempeño de las actividades de la vida diaria. Hemos llevado a cabo un ensayo clínico con 58 ancianos diagnosticados de demencia leve-moderado, ingresados en centros Residenciales de Extremadura y aprobado por el Comité de Bioética de la Universidad de Extr...

  10. Comparison of radiolabeling efficiency of peptides containing the RGD domain using the Tc-99M and I-131 radioisotopes

    International Nuclear Information System (INIS)

    Sobral, Danielle V.; Cabral, Francisco Romero; Malavolta, Luciana

    2017-01-01

    Full text: Introduction: Radiolabeled peptides have become very important in nuclear medicine and oncology in recent years mainly because they represent the molecular basis for in vivo imaging and radiopharmaceutical therapy with high specificity and affinity for over expressed receptors in tumors (Thno 2(5):481-501, 2012 / Drug Discov. Today. 7:1224-1232, 2012). In this context, peptides containing the RGD domain which possess high affinity for the αvβ3 integrin receptor have become an important tool in a wide variety tumor, including glioblastoma (Exp. Opin. Drug Deliv. 8:1041- 1056, 2011). Objective: The goal of this work was to compare the radiolabeling efficiency of the GRGDYV and GRGDHV peptides when radiolabeled with the 131 I and 99m Tc radioisotopes, respectively, as well as, to evaluate the features of synthesized complexes. Methods: The GRGDYV and GRGDHV fragments were manually synthesized by peptide synthesis in solid phase accordingly to the Fmoc protocol and purified by preparative HPLC. The GRGDYV and GRGDHV peptides were radiolabeled with the I-131 and Tc-99m radioisotopes respectively, through of the direct method of radiolabeling. The radioiodination was evaluated and optimized using the methodology of Chloramine-T and for the peptide containing the histidine aminoacid the tricarbonyl method was used. Radiochemical yield analyses of [ 131 I]-GRGDYV and [ 99m Tc]-GRGDHV peptides were performed by thin layer chromatography on silica gel TLC-SG (Al) in ACN 95%. The radiolabeled peptides were purified by using solid phase extraction (Sep-Pak C18 filter). The stability studies were realized at 2, 24, 48 and 72 hours in room temperature and refrigerate (4 deg C) for [ 131 I]-GRGDYV and up to 6 hours for the fragment [ 99m Tc]-GRGDHV. Partition coefficient was determinate for both radiopeptides. Results: The peptides [ 131 I]-GRGDYV and [ 99m Tc]-GRGDHV were efficiently synthesized, radiolabeled and showed radiochemical yield of 91.02% ± 1.68 (n=5

  11. Comparison of radiolabeling efficiency of peptides containing the RGD domain using the Tc-99M and I-131 radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Sobral, Danielle V.; Cabral, Francisco Romero; Malavolta, Luciana [Santa Casa de São Paulo, SP (Brazil). Faculdade de Ciências Médicas; Durante, Ana C. Ranucci; Miranda, Ana C. Camargo; Barbosa, Marycel R. F.Figols de [Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, SP (Brazil)

    2017-07-01

    Full text: Introduction: Radiolabeled peptides have become very important in nuclear medicine and oncology in recent years mainly because they represent the molecular basis for in vivo imaging and radiopharmaceutical therapy with high specificity and affinity for over expressed receptors in tumors (Thno 2(5):481-501, 2012 / Drug Discov. Today. 7:1224-1232, 2012). In this context, peptides containing the RGD domain which possess high affinity for the αvβ3 integrin receptor have become an important tool in a wide variety tumor, including glioblastoma (Exp. Opin. Drug Deliv. 8:1041- 1056, 2011). Objective: The goal of this work was to compare the radiolabeling efficiency of the GRGDYV and GRGDHV peptides when radiolabeled with the {sup 131}I and {sup 99m}Tc radioisotopes, respectively, as well as, to evaluate the features of synthesized complexes. Methods: The GRGDYV and GRGDHV fragments were manually synthesized by peptide synthesis in solid phase accordingly to the Fmoc protocol and purified by preparative HPLC. The GRGDYV and GRGDHV peptides were radiolabeled with the I-131 and Tc-99m radioisotopes respectively, through of the direct method of radiolabeling. The radioiodination was evaluated and optimized using the methodology of Chloramine-T and for the peptide containing the histidine aminoacid the tricarbonyl method was used. Radiochemical yield analyses of [{sup 131}I]-GRGDYV and [{sup 99m}Tc]-GRGDHV peptides were performed by thin layer chromatography on silica gel TLC-SG (Al) in ACN 95%. The radiolabeled peptides were purified by using solid phase extraction (Sep-Pak C18 filter). The stability studies were realized at 2, 24, 48 and 72 hours in room temperature and refrigerate (4 deg C) for [{sup 131}I]-GRGDYV and up to 6 hours for the fragment [{sup 99m}Tc]-GRGDHV. Partition coefficient was determinate for both radiopeptides. Results: The peptides [{sup 131}I]-GRGDYV and [{sup 99m}Tc]-GRGDHV were efficiently synthesized, radiolabeled and showed

  12. Optimizing the number of equivalent iterations of 3D OSEM in SPECT reconstruction of I-131 focal activities

    International Nuclear Information System (INIS)

    Koral, Kenneth F.; Kritzmaan, James N.; Rogers, Virginia E.; Ackermann, Robert J.; A Fessler, Jeffrey

    2007-01-01

    To externally estimate the radiation dose to a tumor during therapy with I-131 radiopharmaceuticals, and its distribution, one must accurately estimate activity, and its distribution, by means of SPECT imaging. Our objective is to characterize the quantification of the total activity in focal targets and in their uniform background, and of the activity distribution within the targets, after 3D Ordered Subsets Expectation Maximization (OSEM) reconstruction with attenuation and scatter correction and no post smoothing, in the good-counting-statistics case. A cylindrical phantom containing seven spheres simulating tumors, ranging in volume from 209 to 4.2 cm 3 , and filled with an I-131 water solution containing background, was imaged. A Siemens Symbia SPECT/CT scanner was used to acquire 128x128 projection images, employing 60 angles over 360 o . With dynamic SPECT, 10 sequential acquisitions of 15 min duration each were obtained and each was reconstructed with particular values of the number of subsets and the number of iterations. Let the product of the number of subsets times the number of iterations equal the equivalent number of iterations, EI. The counts-to-activity conversion factor was derived from the average ratio of total count divided by true activity for the largest sphere at the largest value of EI. Then, for the activity of each sphere at each of the values of EI, we evaluated (1) the fractional variance (variance in estimate over true activity), (2) the fractional bias (average estimate bias over true activity) and (3) the fractional error (the root mean square error (RMSE) in the estimate divided by the true activity). The fractional bias and fractional variance were smaller for the larger spheres compared to the smaller (the fractional bias decreased faster with an increase in the fractional variance for them as well). The RMSE was dominated by the bias. The fractional error decreased as EI increased for all sphere sizes. The minimum average value

  13. Immunoscintigraphy of human pancreatic carcinoma in nude mice with I-131-F(ab')/sub 2/-fragments of monoclonal antibodies

    International Nuclear Information System (INIS)

    Senekowitsch, R.; Maul, F.D.; Wenisch, H.J.C.; Kriegel, H.; Hor, G.

    1985-01-01

    In the present study radioiodinated F(ab')/sub 2/-fragments of CA19-9 and antibody that reacts specifically with human gastrointestinal cancer were examined for their ability to detect human pancreatic carcinoma hosted in nude mice. Tumor-bearing mice received 80μCi of I-131-F(ab')/sub 2/ with a specific activity of 1.8μCi/μg. All mice were imaged after the injection and every 24hr up to 6 days. The retained radioactivity was also registered with a whole-body counter immediately after imaging. As a control F(ab's)/sub 2/ of a nonspecific antibody were administered in parallel to another group of animals bearing the same tumor. Three animals of each group were killed at 1,2,4 and 8 days for determination of the distribution of both labeled antibody-fragments. On scintigraphic images obtained with the CA19-9-F(ab')/sub 2/ the tumors could be visualized 24hr after injection, the best dilineation however was achieved 96hr p.i.. The biodistribution data exhibited a more rapid blood clearance for the specific fragments compared to that for the unspecific ones. Tumors showed an increase in uptake up to 48hr reaching 1.7% of the injected dose per gram, declining to values of 0.08%/g at day 6 p.i.. The highest tumor-to-blood ratios were found after 96h. They were 7 for the CA19-9-fragments compared to 1.5 for the unspecific fragments. The whole body counting revealed a more rapid excretion for the fragments of the specific monoclonal antibodies than for the unspecific ones. In summary the authors were able to show that CA19-9-F(ab')/sub 2/-fragments can be used for immunodetection of human pancreatic carcinoma hosted in nude mice

  14. Clinical Significance of Diffuse Intrathoracic Uptake on Post-Therapy I-131 Scans in Thyroid Cancer Patients

    International Nuclear Information System (INIS)

    Choi, Hyun Su; Kim, Sung Hoon; Park, Sonya Youngju; Park, Hye Lim; Seo, Ye Young; Choi, Woo Hee

    2014-01-01

    The purpose of this study was to identify the frequency and possible cause of diffuse intrathoracic uptake on post-therapy I-131 scans in thyroid cancer patients. We retrospectively reviewed 781 post-therapy scans of 755 thyroid cancer patients who underwent total thyroidectomy and radioactive iodine therapy between January and December 2010. Diffuse intrathoracic uptake on post-therapy scans was examined, and clinical patient characteristics including sex, age, regimen for thyroid-stimulating hormone (TSH) stimulation (thyroid hormone withdrawal or recombinant human TSH injection), TSH, thyroglobulin (Tg) and anti-thyroglobulin antibody (anti-Tg Ab) levels, therapeutic dose of radioactive iodine therapy and prior history of radioactive iodine therapy were recorded.Scan findings were correlated with chest CT, chest radiographs, laboratory tests and/or clinical status. Diffuse intrathoracic uptake without evidence of pathologic condition was categorized as indeterminate. The association between clinical characteristics and intrathoracic uptake were analyzed for negative intrathoracic uptake and indeterminate uptake groups. Diffuse intrathoracic uptake on post-therapy scans was demonstrated in 39 out of 755 (5.2 %) patients, among which 3 were confirmed as lung metastasis. The 14 patients that showed high Tg or anti-Tg Ab levels were considered to be at risk of having undetected micrometastasis on other imaging modalities. The remaining 22 were indeterminate (2.9 %). Upon comparison of negative intrathoracic uptake and indeterminate uptake groups, TSH stimulation by thyroid hormone withdrawal was shown to be significantly correlated with diffuse intrathoracic uptake (p <0.05). The frequency of diffuse intrathoracic uptake on post-therapy scans was 5.2 % and could be seen in thyroid cancer patients with underlying lung metastasis as well as those without definite pathologic condition. In the latter, there was a higher frequency for diffusely increased intrathoracic

  15. Terapia familiar en los trastornos de personalidad

    Directory of Open Access Journals (Sweden)

    Laura Rodríguez Moya

    2013-06-01

    Full Text Available La enfermedad mental afecta no solo al paciente sino también a su familia, dificulta la comunicación intrafamiliar, puede generar patologías adicionales en los familiares y todo ello empeorar la evolución del trastorno. Las terapias familiares de tipo psicoeducativo mejoran el pronóstico de la enfermedad y además previenen la aparición de otros trastornos en los familiares. Los elementos más importantes de estas intervenciones son la psicoeducación sobre el trastorno, el re-establecimiento de una relación sana entre paciente-familia, el establecimiento de límites, la mejora de la comunicación familiar y el establecimiento de relaciones con la red social extensa, para evitar el aislamiento tanto de la familia como del paciente. Las intervenciones mixtas, individuales y familiares, han demostrado ser muy útiles en el caso de los trastornos de personalidad, en concreto en el Trastorno Límite de Personalidad (TLP.

  16. Thyroid remnant ablation using 1,110 MBq of I-131 after total thyroidectomy. Regulatory considerations on release of patients after unsealed radioiodine therapy

    International Nuclear Information System (INIS)

    Kusakabe, Kiyoko; Yokoyama, Kunihiko; Ito, Koichi

    2012-01-01

    This study was undertaken to measure the radiation exposure level of caregivers following outpatient NaI (I-131) 1,110 MBq therapy for remnant thyroid ablation after total thyroidectomy in patients with differentiated thyroid cancer, and to evaluate the influence of activities of daily living on radiation exposure level, with the goal of proposing an optimum method of I-131 therapy. The study included 37 patients with differentiated thyroid cancer, who had undergone total thyroidectomy and received outpatient based remnant thyroid ablation using NaI (I-131) 1,110 MBq, who were satisfying the following requirements: patients who have no evidence of distant metastases, whose living environments were appropriate for outpatient I-131 (1,110 MBq) therapy, and patients who gave written informed consent. The dose rate at a distance of 1 m from the body surface of the patient at the moment of release was measured using survey meters of the GM type or ionization chamber type. The dose level for the caregiver was measured with a personal dosimeter in all cases. The dose rate at a distance of 1 m from the patient's body surface 1 h after I-131 administration was in the range of 29-115 μSv/h (mean 63.8 μSv/h). The 7-day cumulative effective dose of caregivers was 0.11±0.08 mSv, on an average, in 34 dosimeters. In 31 of 34 dosimeters, cumulative effective dose of caregivers was below 0.2 mSv. Dose levels exceeding 0.2 mSv were recorded in 3 cases (0.21, 0.35 and 0.43 mSv in one case each). These results suggest that the exposure level of family members (caregiver and others) was minimal and is lower than the radiation levels affecting human environments. Outpatient-based remnant thyroid ablation with I-131 (1,110 MBq) performed after total thyroidectomy in patients with differentiated thyroid cancer is safe if applied in accordance with the appropriate supervision and guidance by experts with certain qualifications. (author)

  17. Avaliação prospectiva dos resultados a longo prazo da terapia intradiscal percutânea lombar por radiofrequência Evaluación prospectiva de resultados a largo plazo de la terapia intradiscal percutánea lumbar con radiofrecuencia Prospective evaluation of long-term results of percutaneous lumbar intradiscal radiofrequency therapy

    Directory of Open Access Journals (Sweden)

    Daniel Ferreira Ghedini

    2011-01-01

    Full Text Available OBJETIVO: Avaliar os resultados do tratamento da lombalgia crônica discogênica com a técnica IDET (Intradiscal Electrothermal Therapy em um acompanhamento maior que dois anos de pós-operatório (PO. MÉTODOS: Estudo prospectivo, avaliando 23 pacientes consecutivos com diagnóstico de lombalgia crônica discogênica tratados com IDET entre fevereiro de 2003 e fevereiro de 2006. A dor foi considerada discogênica em caso de discografia positiva ou imagem compatível com a ressonância magnética, segundo os critérios de Horton e Daftari. Os parâmetros clínicos (EVA e Oswestry foram avaliados no pré-operatório, no retorno com 6, 12, 18, 24 e mais de 48 meses de pós-operatório. RESULTADOS: A média de idade dos pacientes foi de 42,09 (variação de 26 a 51 anos. A média do período do acompanhamento foi de 32,55 meses (variação de 6 a 68 meses. A média do índice de dor (EVA foi de 7,07 ± 1,90, reduzindo-se para 2,47 ±1,876 em 6 meses, 2,69 ±1,82 em 12 meses, 3,63 ±1,75 em 18 meses e 5,73 ±2,12 em 24 meses. A média do índice Oswestry foi de 39,26 ± 11,96 no pré-operatório, reduzindo-se para 19,44±15,72 em 6 meses, 19,8 8 ±15,45 em 12 meses, 26,62 ±13,84 em 18 meses e 31,87 ±14,94 em 24 meses. Os resultados não se mantiveram no acompanhamento de 48 meses. CONCLUSÃO: O IDET mostrou resultados satisfatórios como alternativa paliativa no controle da dor e da incapacidade funcional num período de 24 meses. Os bons resultados deterioraram-se com 48 meses e houve uma tendência de retorno à sintomatologia inicial.OBJETIVO: Evaluar los resultados del tratamiento del lumbago crónico del disco usando la técnica IDET (electrotermocoagulación intradiscal en un seguimiento mayor que dos años de pos operatorio. MÉTODO: Estudio prospectivo, evaluando 23 pacientes, consecutivamente, con diagnóstico de lumbago crónico del disco tratados con IDET desde febrero de 2003 hasta febrero de 2006. El disco fue considerado como siendo

  18. Terapia anti-retroviral: fatores que interferem na adesão de crianças com HIV/AIDS Terapia anti-retroviral: factores que interfieren en la adherencia de niños con VIH/SIDA Antiretroviral therapy: factors interfering in the adherence of children with HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Ana Claúdia Feitosa

    2008-09-01

    Full Text Available O objetivo deste estudo foi conhecer os fatores que interferem na adesão à terapêutica medicamentosa em crianças infectadas pelo HIV/AIDS, relatados por 12 cuidadores em um serviço de referência em AIDS, em Fortaleza-CE. Os dados foram obtidos mediante entrevista, e, com eles, foram apurados fatores que dificultaram a adesão terapêutica, evidenciando relatos referentes à apresentação da droga, horário da tomada do medicamento, efeitos colaterais, falta na distribuição de medicamento gratuito, dificuldade de acesso regular ao serviço de saúde e problemas financeiros. Constatou-se a importância de conhecer o contexto social no qual a criança está inserida e as dificuldades no uso dos anti-retrovirais para intervir de forma eficiente e possibilitar uma melhor qualidade de vida às crianças.La finalidad de este estudio fue conocer los factores que interfieren en la adherencia a la terapéutica medicamentosa en niños infectados por el VIH/sida relatados por 12 cuidadores en un servicio de referencia en sida, en Fortaleza-CE, Brasil. Los datos fueron obtenidos mediante entrevista, y, con ellos fueran apurados factores que dificultaron la adherencia terapéutica, evidenciando relatos referentes a la presentación de la droga, horario de la toma del medicamento, efectos colaterales, falta en la distribución de medicamento gratuito, dificultad de acceso regular al servicio de salud y problemas financieros. Se constató la importancia de conocer el contexto social en que el niño está insertado y las dificultades en el uso de los anti-retrovirales para intervenir de forma eficiente y posibilitar una mejor calidad de vida a los niños.This study aimed to get to know the factors that interfere in medication treatment adherence among children infected by HIV/aids, as reported by 12 caregivers in a service reference to aids in Fortaleza/CE, Brazil. Data were collected through interviews, verifying factors that made treatment adherence

  19. Efecto de la aplicación de terapia conductual en la adquisición de destrezas básicas para el aprendizaje, en tres niños con autismoa partir de la expresión artística

    Directory of Open Access Journals (Sweden)

    Hannia Cabezas Pizarro

    2004-01-01

    Full Text Available El presente estudio muestra el efecto de la utilización de terapia conductual aplicada, en tres niños con autismo, y cuyo propósito fue el de desarrollar aquellas conductas de entrada básicas para el aprendizaje como son el permanecer sentados, el control de llanto, el establecimiento de contacto ocular y la identificación del yo, consideradas habilidades básicas que deben tener los niños para incursionar en el proceso educativo. Una vez que el niño adquiere esta gama de habilidades, estos repertorios conductuales se convierten a su vez en básicos para destrezas más complejas. Siguiendo este modelo, se trabajó una segunda área que se denominó conducta intermedia, que requiere de las habilidades previamente establecidas, y dentro de las que se citan el seguimiento de instrucciones, la discriminación de objetos y la identificación de las partes del cuerpo, a su vez este repertorio conductual se convirtió en básico para desarrollar habilidades más complejas como el reconocimiento de colores, de modo que unas conductas se convierten en requisitos de otras, hasta llevar a término un programa de intervención educativo. El proceso de intervención educativa, contempló una gama amplia de habilidades, sin embargo para efectos de este estudio, se seleccionó una muestra representativa de cada área

  20. A simple low-cost of liquid I-131 dispenser for routine radiopharmaceutical dispensing at nuclear medicine department, Institut Kanser Negara

    Energy Technology Data Exchange (ETDEWEB)

    Said, M. A.; Suhaimi, N. E. F. [Fakulti Sains dan Teknologi, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi Selangor (Malaysia); Ashhar, Z. N., E-mail: aminhpj@gmail.com [Institut Kanser Negara, No 4, Jalan P7, Presint 7, 62250 Putrajaya (Malaysia); Zainon, R. [Advanced Medical & Dental Institute, Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang (Malaysia)

    2016-01-22

    In routine radiopharmaceutical Iodine-131 ({sup 131}I) dispensing, the amount of radiation dose received by the personnel depends on the distance between the personnel and the source, the time spent manipulating the source and the amount of shielding used to reduce the dose rate from the source. The novel iRAD-I131 dispenser using recycle {sup 131}I liquid lead pot will lead into low cost production, less maintenance and low dose received by the personnel that prepared the {sup 131}I. The new fabricated of low cost {sup 131}I dispenser was tested and the dose received by personnel were evaluated. The body of lead material is made from 2.5 cm lead shielded coated with epoxy paint to absorb the radiation dose up to 7.4 GBq of {sup 131} I. The lead pot was supported with two stainless steel rod. The Optically Stimulated Luminescence (OSL) nanodot was used in this study to measure the dose rate at both extremities for every personnel who prepared the {sup 131}I. Each OSL nanodot was attached at the fingertip. Three different personnel (experienced between one to ten years above in preparing the radiopharmaceuticals) were participated in this study. The average equivalent dose at right and left hand were 122.694 ± 121.637 µSv/GBq and 77.281 ± 62.146 µSv/GBq respectively. This study found that the dose exposure received using iRAD-I131 was less up to seven times compared to the conventional method. The comparison of experimental data using iRAD-I131 and established radiopharmaceutical dispenser was also discussed. The innovation of {sup 131}I dispenser is highly recommended in a small radiopharmaceutical facility with limited budget. The novel iRAD-I131 enables implementation of higher output liquid dispensing with low radiation dose to the personnel.

  1. Clinical importance of technetium-99m-methoxyisobutylisonitrile (MIBI) scintigraphy in differentiated thyroid carcinoma patients with elevated thyroglobulin levels and negative I-131 scanning results

    International Nuclear Information System (INIS)

    Kuecuek, N.O.; Kulak, H.A.; Aras, G.

    2006-01-01

    The aim of this study was to evaluate the potential contribution of Tc-99m-MIBI scintigraphy to the follow-up of patients with differentiated thyroid carcinoma, who had elevated Tg levels and negative I-131 whole-body scan (WBS) results. In this retrospective study, we evaluated 28 patients with differentiated thyroid carcinoma, who had total or near total thyroidectomy followed by an ablative dose of I-131 at various time intervals (15 women, 13 men; mean age 43±17 years). All patients were treated with T4 suppression. After a mean follow-up period of 6.1 years (range 3-15) all patients were determined to have a high serum Tg concentrations (>2 ng/ml) and previous negative I-131 WBS results. All patients were examined for metastatic sites using Tc-99m-MIBI scan. Scans were visually evaluated for detecting lymph node metastases and/or local recurrence, lung metastases and skeletal metastases. Tc-99m-MIBI scan demonstrated lesions in 23 patients (83.3%). In five patients with negative Tc-99m-MIBI scan findings (FN results): Chest CT showed small-sized mediastinal LN metastases in 2 patients and lung metastases in another 2 patients (<1 cm); Neck CT showed small-sized cervical LN involvement in 1 patient. The sensitivity of detection for neck was 94.4%, for lung 63.6%, and for bone lesions 100%. For all scan sites taken together, the sensitivity of disease detection was 83.3%, the specificity was 50%, positive predictive value (PPV) was 96.2%, and finally negative predictive value (NPV) was 16.7%. We concluded that Tc-99m-MIBI scan should be considered as a supplementary scintigraphic method for the follow-up of patients with high serum Tg levels and negative I-131 WBS results, and it can help clinicians in making the decision to treat these patients. (author)

  2. Preliminary report of a fetal-thyroid overexposure case due to the administration of I-131 during the second trimester of pregnancy

    International Nuclear Information System (INIS)

    Gimenez, J.C.; Gutierrez, S.; Alcaraz, G.

    1992-01-01

    Sixty to eighty percent of patients with Graves's disease have antibodies directed against thyroglobulin or against thyroid microsomes. A contemporary interpretation is that thyroid stimulatory inmunoglobuline TSI mimics the action of TSH and stimulate the synthesis and release of thyroid hormone. In patient whose thyroids are capable of responding to such a trophic stimulus, TSI may be the mediator of hyperthyroxinemia. TSI cross the placenta and cause transient hyperthyroidism in some neonates (0,5-1 %) born to mothers who have high circulating levels of the antibodies. As regards adults aged 25 and up, administering I-131 radioactive iodine seems to be a satisfactory treatment for Graves' disease. Such a treatment, however, is to be avoided when treating either pregnant or breast-feeding women due to the effects that irradiation is likely to cause to the fetus or the suckling child. Even though such effects depend on the intrauterine developmental stage, the principal effects are as follows: (a) The embryo may be lethally affected; (b) Malformations and structure changes, or changes in the child's development are likely to occur; (3) The child may be mentally retarded; (4) An induction to cancer and leukemia is possible, and (e) Hereditary effect, may be expected. Moreover, it is a well-known fact that the fetal thyroid is able to capture and integrate iodine as of the 10th/12th gestation week. Thus, administering I-131 according to prescribed doses may define or suppress the thyroid function. Therefore, the highest precautions must be taken in order not to carelessly administer I-131 therapeutic doses to pregnant women. Any woman within the reproductive capacity range should be strongly advised that the pregnancy test is to be performed to avoid her fetus being irradiated. Precisely, the present paper deals with the inadvertent administering an I-131 therapeutic dose to pregnant woman with Graves disease whose child -unexpectedly enough- turned out to be

  3. Menopausia y terapia hormonal de reemplazo

    OpenAIRE

    Cobo, Edgard; Fundación Valle de Lili

    1996-01-01

    La terapia hormonal en la menopausia/ menopausia y terapia hormonal de reemplazo (THR)/¿Qué es la menopausia?/ ¿Porqué hay tanto “ruido” acerca de la menopausia, si es un evento natural en la vida de toda mujer?/ ¿Qué significa terapia hormonal de reemplazo?(THR)/ ¿Cuáles son las ventajas de recibir la THR?/ Mejoraría en la calidad de vida/ Prevención de enfermedad/ ¿Quiere esto decir que absolutamente todas las mujeres deber recibir una THR?/ ¿Cuáles son las molestias más frecuentes a las qu...

  4. Normalization of lymphocyte count after high ablative dose of I-131 in a patient with chronic lymphoid leukemia and secondary papillary carcinoma of the thyroid: case report

    International Nuclear Information System (INIS)

    Thom, Anneliese Rosmarie Gertrud Fischer; Hamerschlak, Nelson; Osawa, Akemi; Santos, Fabio Pires de Souza; Pasqualin, Denise da Cunha; Wagner, Jairo; Yamaga, Lilian Yuri Itaya; Cunha, Marcelo Livorsi da; Campos Neto, Guilherme de Carvalho; Funari, Marcelo Buarque de Gusmao; Teles, Veronica Goes

    2014-01-01

    The authors report the case of a 70-year-old male patient with chronic lymphoid leukemia who presented subsequently a papillary carcinoma of the thyroid with metastases to regional lymph nodes. The patient was treated with surgical thyroidectomy with regional and cervical lymph node excision and radioiodine therapy (I-131). The protocolar control scintigraphy 4 days after the radioactive dose showed I-131 uptake in both axillae and even in the inguinal regions. PET/CT showed faint FDG-F-18 uptake in one lymph node of the left axilla. An ultrasound guided fine needle biopsy of this lymph node identified by I-131 SPECT/CT and FDG-F-18 PET/CT revealed lymphoma cells and was negative for thyroid tissue and thyroglobulin content. The sequential blood counts done routinely after radiation treatment showed a marked fall until return to normal values of leucocytes and lymphocytes (absolute and relative), which were still normal in the last control 19 months after the radioiodine administration. Chest computed tomography showed a decrease in size of axillary and paraaortic lymph nodes. By immunohistochemistry, cells of the lymphoid B lineage decreased from 52% before radioiodine therapy to 5% after the procedure. The authors speculate about a possible sodium iodide symporter expression by the cells of this lymphoma, similar to some other non-thyroid tumors, such as breast cancer cells. (author)

  5. The outcome of I-131 ablation therapy for intermediate and high-risk differentiated thyroid cancer using a strict definition of successful ablation

    International Nuclear Information System (INIS)

    Watanabe, Ken; Uchiyama, Mayuki; Fukuda, Kunihiko

    2017-01-01

    This article examines the outcome of radioactive iodine ablation therapy for thyroid cancer in nigh-risk patients and investigates background factors influencing ablation failure. We included 91 patients in this retrospective analysis and evaluated the ablation success rate. Successful ablation was defined as the absence of visible iodine-131 (I-131) accumulation in the thyroid bed after whole-body scans and thyroglobulin levels <2 ng/ml in a TSH-stimulated state after ablation. We extracted data on patients' age, sex, I-131 dose, pathology, resection stump findings, tumor T category and thyroglobulin levels, which could affect ablation outcome. Successful ablation was achieved in only 14 patients (15.4%). Pre-ablation serum thyroglobulin levels were significantly higher in the ablation failure group than in the success group (P < 0.001), while no significant differences were found for other factors between the groups. Furthermore, thyroglobulin levels >10 ng/ml were significantly related to ablation failure after multivariate analysis (odds ratio 27.2; 95% confidence interval 2.469-299.7; P = 0.007). The ablation success rate was very low because of high thyroglobulin levels, even with high-dose I-131. High-risk patients, especially those with high thyroglobulin levels (>10 ng/ml), are unlikely to reach levels low enough to meet successful ablation criteria. (author)

  6. The outcome of I-131 ablation therapy for intermediate and high-risk differentiated thyroid cancer using a strict definition of successful ablation.

    Science.gov (United States)

    Watanabe, Ken; Uchiyama, Mayuki; Fukuda, Kunihiko

    2017-09-01

    This article examines the outcome of radioactive iodine ablation therapy for thyroid cancer in high-risk patients and investigates background factors influencing ablation failure. We included 91 patients in this retrospective analysis and evaluated the ablation success rate. Successful ablation was defined as the absence of visible iodine-131 (I-131) accumulation in the thyroid bed after whole-body scans and thyroglobulin levels sex, I-131 dose, pathology, resection stump findings, tumor T category and thyroglobulin levels, which could affect ablation outcome. Successful ablation was achieved in only 14 patients (15.4%). Pre-ablation serum thyroglobulin levels were significantly higher in the ablation failure group than in the success group (P 10 ng/ml were significantly related to ablation failure after multivariate analysis (odds ratio 27.2; 95% confidence interval 2.469-299.7; P = 0.007). The ablation success rate was very low because of high thyroglobulin levels, even with high-dose I-131. High-risk patients, especially those with high thyroglobulin levels (>10 ng/ml), are unlikely to reach levels low enough to meet successful ablation criteria.

  7. Feminismo e terapia: a terapia feminista da família - por uma psicologia comprometida

    OpenAIRE

    Narvaz,Martha Giudice; Koller,Sílvia Helena

    2007-01-01

    O objetivo deste trabalho é destacar a terapia feminista da família enquanto abordagem crítica no campo das psicoterapias e das terapias familiares. Inicialmente, descrevemos o feminismo enquanto campo político, teórico e epistemológico, bem como a incorporação do paradigma feminista ao campo das psicoterapias. Descrevemos também o surgimento da vertente feminista da terapia familiar e as principais críticas feministas às terapias familiares sistêmicas tradicionais. Ao final, destacamos a ter...

  8. The usefulness of I-131 MIBG scintigraphy in assessing the staging of neuroectodermal tumors in children - Our experience

    International Nuclear Information System (INIS)

    Budlewski, T.; Rogowski, F.; Luczynski, W.; Krawczuk-Rybak, M.

    2004-01-01

    Full text: Neuroendodermal tumors include pheochromocytoma, paraganglioma, medullary thyroid cancer and neuroblastoma. These malignant tumors derive from the primitive neural crest, which develops to sympathic nervous system. The tumors consist of cells that are capable of incorporating the amine precursors such as I-131 MIBG. The most common malignant tumor in childhood is neuroblastoma. The tested group included patients with neuroblastoma and one with pheochromocytoma treated in the Department of Oncology at the Paediatric University Hospital in Bialystok. There were 8 patients between the ages of 2 and 13. They have all undergone standard whole body scanning with a tomographic Nucline X-Ring camera made by Mediso, fitted with high-energy all purpose parallel hole collimator, a scan speed 5cm/ min and static images of 250,000 counts or 10 min per image. The study was performed 24-48 h after I-131 MIBG injection of 35 MBq activity. The results were obtained by antero-posterior and posterio-anterior projections (a whole body scan) and, if necessary, additional static images of chest and abdomen, skull, pelvis, and lower limbs. Clinical Characteristics of the Group: M.E. 12-year-old child with a right suprarenal tumor with morrow metastases. HP-neuroblastoma. The child was treated with a preoperative chemotherapy, operated and given postoperative chemotherapy (palliative therapy). The MIBG scintigraphy showed hypermetabolic focus in the pelvis and in the left vertex bone. Clinical test pointed to the progress of the disease. M.J. 6-year-old child with infiltrative retroperitoneal on both sides of celiac trunk with a metastases to mediastinum and bone marrow. HP-neuroblastoma. The first MIBG scintigraphy performed after Tsishidy operative procedure was negative. The second MIBG scintigraphy, one year later showed metastases to thigh bone, spine, and sacroiliac joint. Clinically proven progress of the disease. G.G. 2-year-old child with facial skeleton tumor and

  9. A prospective randomized study of the efficacy and cost-effectiveness of high and low dose regimens of I-131 treatment in hyperthyroidism.

    Science.gov (United States)

    Pusuwan, Pawana; Tuntawiroon, Malulee; Sritongkul, Nopamol; Chaudakshetrin, Pachee; Nopmaneejumruslers, Cherdchai; Komoltri, Chulalak; Thepamongkhol, Kullathorn; Khiewvan, Benjapa; Tuchinda, Pongpija; Sriussadaporn, Sutin

    2011-03-01

    To compare the efficacy and cost-effectiveness of high and low dose regimens of I-131 treatment in patients with hyperthyroidism. One hundred fifty patients with proven hyperthyroidism were randomly allocated into the high (74 patients) and low (76 patients) dose regimen of I-131 treatment. Four patients of the high dose group and one patient of the low dose group were excluded because of lost follow-up. A gland-specific dosage was calculated on the estimated weight of thyroid gland and 24-hour I-131 uptake. The high and low I-131 dose regimens were 150 microCi/gm and 100 microCi/gm, respectively. The first mean radioiodine activity administered to the high and low dose group was 10.2 and 8 mCi, respectively. Repeated treatment was given to 25 patients of the high dose group and 40 patients of the low dose group. Clinical outcome and calculated costs for outpatient attendances, and laboratory tests together with initial and subsequent treatments were evaluated for one year after I-131 treatment. Elimination of hyperthyroidism that resulted in either euthyroidism or hypothyroidism was classified as therapeutic success. The cost effectiveness was also compared. At 6 months after treatment, 45 (64.3%) patients receiving high dose and 59 (78.7%) patients receiving low dose were hyperthyroidism. Clinical outcome at one year showed persistence of hyperthyroidism in 21 (30%) patients of the high dose regimen and 36 (48%) patients of the low dose regimen. At one year post treatment, it was demonstrated that the high dose regimen could eliminate hyperthyroidism in a significantly shorter time than the low dose regimen, i.e., 259.6 days and 305.5 days, respectively, p = 0.008). For the persistent hyperthyroid patients, the average total cost of treatment in the low dose group was significantly higher than that of the high dose group, i.e., 13,422.78 baht and 10,942.79 baht, respectively; p = 0.050). A high dose regimen of radioactive iodine treatment is more effective than

  10. The prevalence of thyroid tissue along the thyroglossal tract on SPECT/CT following I131 ablation therapy after total thyroidectomy for thyroid cancer

    International Nuclear Information System (INIS)

    Barber, T.W.; Cherk, M.H.; Yap, K.S.K.; Kalff, V.; Topliss, D.J.; Serpell, J.W.

    2015-01-01

    Full text of publication follows. Aim: the aims of this study are first to determine the prevalence of thyroid tissue along the thyroglossal tract on SPECT/CT and secondly to assess the contribution of this tissue to total neck I-131 activity in patients treated with I-131 ablation therapy after total thyroidectomy for thyroid cancer. Materials and methods: a total of 63 consecutive patients with well differentiated thyroid cancer treated with total thyroidectomy underwent whole body planar imaging and SPECT/CT of the neck 48 hours following ablative I-131 therapy. On SPECT/CT, thyroglossal tract thyroid tissue was defined as radioiodine activity in the anterior neck, superior to the thyroid bed in close proximity to the midline without evidence of localisation to lymph nodes. On planar imaging, thyroglossal tract thyroid tissue was defined as linear radioiodine activity in the midline of the neck superior to the thyroid bed. SPECT/CT and planar images were classified by two independent reviewers as positive, negative or equivocal with interobserver agreement quantified using a Kappa score. Disagreement was resolved using a third reviewer. Quantitation of thyroglossal tract thyroid tissue and total neck I-131 activity was performed using region of interest analysis on planar imaging following localisation on SPECT/CT. Results: thyroglossal tract thyroid tissue was present in 31/63 (49%; 95% CI: 37-61%) patients on SPECT/CT. In these 31 patients, thyroglossal tract thyroid tissue contributed to an average of 49% of total neck activity. Interobserver agreement was substantial on SPECT/CT (Kappa = 0.76; 95% CI: 0.61-0.91) and fair on planar imaging (Kappa = 0.31; 95% CI: 0.15-0.47). Conclusion: thyroid tissue along the thyroglossal tract was present in one half of patients in our study population and can contribute to a significant amount of total neck I-131 activity. Given the high prevalence of thyroglossal tract thyroid tissue, our results suggest that total neck

  11. NUEVAS TERAPIAS EN EL MANEJO DE LOS GLIOMAS DE ALTO GRADO

    Directory of Open Access Journals (Sweden)

    Dr. Raúl Valenzuela

    2017-05-01

    Full Text Available El reto de mejorar el tratamiento actual de los gliomas de alto grado ha sido abordado con inmensa creatividad, desarrollándose una gran variedad de estrategias para este fin. El análisis interino de un estudio fase III mostró que el beneficio de la terapia standard mejora al complementarla con terapia de campos eléctricos alternantes (Novo TTF-100 A; dadas las limitaciones de un análisis interino, queda por establecer la real magnitud y relevancia clínica de esta mejoría. El presunto beneficio de usar tratamiento antiviral contra citomegalovirus es muy controvertido y su utilidad no se ha demostrado en forma fehaciente. Las terapias antiangiogénicas han mostrado ser útiles para el manejo de las recurrencias, al menos como tratamiento sintomático, pero no han demostrado mejorar la sobrevida en pacientes de novo. La terapia dirigida contra señales intracelulares de crecimiento, conceptualmente muy atractiva, todavía no ha logrado resultados clínicos exitosos. Hay datos preliminares promisorios respecto al uso clínico de vacunas antitumorales y de inmunomodulación con inhibidores de “checkpoints”; también hay algunos datos preliminares a favor del uso de virus oncolíticos. La terapia genética parece estar en etapas aún muy tempranas de su desarrollo y probablemente demore más tiempo en llegar a demostrar utilidad clínica.

  12. Terapia de resgate com amiodarona em crianças com grave disfunção ventricular esquerda causada por veneno de escorpião Terapia de rescate con amiodarona en niños con severa disfunción ventricular izquierda ocasionada por veneno de escorpión Antiadrenergic rescue therapy with amiodarone in children with severe left ventricular dysfunction secondary to scorpion envenomation

    Directory of Open Access Journals (Sweden)

    Justo J. Santiago

    2010-01-01

    Full Text Available FUNDAMENTO: As crianças picadas por escorpião, pressintam ativação maciça do sistema nervoso simpática com vários graus de disfunção sistólica ventricular esquerda. OBJETIVO: Testar um protocolo de resgate em crianças com grave disfunção ventricular esquerda causada por picada de escorpião. Métodos: Quatro crianças após serem picadas por escorpião foram submetidas a: Encubação endotraqueal e suporte respiratório, eletrocardiograma, radiografia de tórax, ecocardiograma e determinação sérica da norepinefrina e troponina I. As análises foram repetidas após 12, 24 e 48 horas. As seguintes medicações intravenosas foram administradas: dobutamina 4-6 μg/kg/min; amiodarona 3 mg/kg durante duas horas, com dose de manutenção de 5 mg/kg/dia; e furosemida 0,5 mg/kg. Amiodarona, dobutamina e furosemida foram administradas durante as primeiras 48 horas. Bloqueadores beta-adrenérgicos e inibidores da enzima conversora da angiotensina foram administrados até 48 após a internação, uma vez que o estado clínico havia melhorado e a fração de ejeção ventricular esquerda encontrava-se acima de 0,35%. RESULTADOS: Na admissão, a dosagem da norepinefrina foi 1.727,50± 794,96 pg/ml, a de troponina I 24,53 ± 14,09 ng/ml e a fração de ejeção do ventrículo esquerdo foi 0,20 ± 0,056. Após 12 horas, os níveis séricos de norepinefrina e de troponina I diminuíram para a metade dos valores iniciais e a fração de ejeção aumentou para 0,32 ± 0,059. Durante as 24 e 48 horas subseqüentes, a fração de ejeção elevou-se para 0,46 ± 0,045 (pFUNDAMENTO: Los niños con picaduras de escorpión sufren activación masiva del sistema nervioso simpático con varios grados de disfunción sistólica ventricular izquierda. OBJETIVO: Probar un protocolo de rescate en niños con disfunción ventricular severa izquierda ocasionada por picadura de escorpión. MÉTODOS: Cuatro niños tras un escorpión picarlas se sometieron a: incubaci

  13. 278. Terapia vacuum assisted closure como tratamiento de mediastinitis en pacientes que se han sometido a trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    M. Schuler

    2012-04-01

    Conclusiones: No hubo ningún caso de muerte hospitala-ria. En todos los pacientes se evidenció una evolución satisfactoria con la utilización de la terapia VAC que permitió la resolución definitiva de la herida sin ser necesaria en ningún caso una reducción en la terapia inmunosupresora.

  14. Pioderma gangrenoso refractario: utilidad de la terapia combinada. Enfoque en beneficio de la terapia hiperbárica en su tratamiento

    OpenAIRE

    Segura Charry, Juan Sebastián; Jaimes, Diego Alejandro; Londoño, John Darío

    2013-01-01

    Resumen El Pioderma Gangrenoso (PG) es un tipo de dermatosis neutrofílica que tiene un componente idiopático, o puede tener asociación con patologías subyacentes sistémicas. Es el resultado de una respuesta exagerada contra estímulos específicos y no específicos. Su primera línea de terapia son los GC; sin embargo, en algunos pacientes, no se logra control de su patología con éste tratamiento (local o sistémico), y se debe recurrir al uso de medicamentos inmunomoduladores, agentes biológicos ...

  15. Doses to the hand during the administration of radiolabeled antibodies containing Y-90, Tc-99m, I-131, and Lu-177

    Energy Technology Data Exchange (ETDEWEB)

    Barber, D.E. [Minnesota Univ., Minneapolis, MN (United States). School of Public Health; Carsten, A.L.; Kaurin, D.G.L.; Baum, J.W. [Brookhaven National Lab., Upton, NY (United States)

    1997-02-01

    Exposure of the hands of medical personnel administering radiolabeled antibodies (RABs) was evaluated on the basis of (a) observing and photo-documenting administration techniques, and (b) experimental data on doses to thermoluminescent dosimeters (TLDs) on fingers of phantom hands holding syringes, and on syringes, with radionuclides in the syringes in each case. Actual exposure data for I-131 and Lu-177 were obtained in field studies. Variations in handling and administration techniques were identified. Dose rates measured using TLDs on the surface of loaded syringes were adjusted for differences in electronic stopping power, absorption coefficients, and attenuation between dosimeters and tissue to estimate dose-to-skin averaged over 1 cm{sup 2} at 7 mg cm{sup {minus}2} depth for Y-90, Tc-99m, I-131, and Lu-177. Dose rate coefficients to the skin, if in contact with the syringe wall, were 89, 1.9, 3.8, and 0.41 {micro}Sv s{sup {minus}1} per 37 MBq (1 mCi) for Y-90, Tc-99m, I-131, and Lu-177, respectively. For dose reduction, when using Y-90 the importance was clearly indicated of (a) avoiding direct contact with syringes containing RABs, if practical, and (b) using a beta-particle shield on the syringe. In using a syringe for injection, doses can best be approximated for the geometry studied by (a) wearing a finger dosimeter on the middle finger, toward the outside of the hand, on the hand operating the plunger, and (b) wearing finger dosimeters on the inner (palm) side of the finger on the hand that supports the syringe for energetic beta-particle emitters, such as Y-90 and Re-188.

  16. Influence of radiolysis and gas-liquid partition of I-131 in accumulated water on late phase source terms at Fukushima NPP accident

    International Nuclear Information System (INIS)

    Hidaka, Akihide

    2014-01-01

    In the process of core cooling at Fukushima Daiichi nuclear power plants accident, large amount of contaminated water was accumulated in the basements of the reactor buildings at Units 1 to 4. The present study estimated the quantities of I-131 and Cs-137 in the water as of late March based on the press-opened data. The estimated ratios of I-131 and Cs-137 quantities to the core inventories are 0.51%, 0.85% at Unit 1, 74%, 38% at Unit 2 and 26%, 18% at Unit 3, respectively. According to the Henry's law, certain fraction of iodine in water could be released to atmosphere due to gas-liquid partition and contribute to increase in the release to environment. A lot of evaluations for I-131 release have been performed so far by severe accident codes such as MELCOR or the reverse estimation with atmospheric dispersion code such as SPEEDI using the monitoring data. The SPEEDI reverse predicted significant release until March 26 while no prediction in MELCOR after March 17. The present study showed that iodine release from accumulated water due to radiolytic conversion from I - to I 2 and gas-liquid partition of I 2 may explain the release between March 17 and 26. This strongly suggests a need for improvement of current MELCOR approach which treats the release only from containment breaks for several days after the core melt. The study also indicates that the release of radioactive iodine from accumulated water in the basements of reactor buildings could become a great concern for the consequence of Fukushima accident. (author)

  17. Multiple model testing using Chernobyl fallout data of I-131 in forage and milk and Cs-137 in forage, milk, beef and grain. Pt. 1

    International Nuclear Information System (INIS)

    Koehler, H.; Peterson, S.R.; Owen Hoffman, F.

    1991-03-01

    Comprehensive measurements of I-131 and Cs-137 in the environment after the Chernobyl accident provided a unique opportunity for the collection of environmental transfer data sets. These come from 13 locations in the northern hemisphere which experienced levels of contamination that spanned approximately three orders of magnitude. Data have been compiled for radionuclide concentrations in air, rain, pasture vegetation, milk, beef and grain. In addition background information has been collated for factors such as prevailing meteorological conditions, location description, and local agricultural practices. Participants were asked to predict radionuclide concentrations in forage, milk, beef and grain from radionuclide concentrations in air, the daily amounts of precipitation and other pertinent information. This was a blind test in that the locations to which the input data referred were not revealed to the participants until after they had submitted their predictions. Twenty-three models were involved in the study. This report compares observations and predictions for deposition, time- integrated concentrations in forage, milk, beef and grain, to help assess understanding of individual processes, time-dependent concentrations in forage, milk and beef. In general, predictions of time-integrated concentration of I-131 and Cs-137 in forage, milk (normalized for forage) and beef are within a factor of 10 of the observations. About 50% of the predictions of I-131 and Cs-137 in forage and just over 30% of the predictions of those nuclides in milk (normalized for forage) fall within a factor of 2 of the observations. Documentation of the measurements, models, methods of analysis and model results is presented in the appendices. (au) (75 refs.)

  18. Doses to the hand during the administration of radiolabeled antibodies containing Y-90, Tc-99m, I-131, and Lu-177

    International Nuclear Information System (INIS)

    Barber, D.E.

    1997-02-01

    Exposure of the hands of medical personnel administering radiolabeled antibodies (RABs) was evaluated on the basis of (a) observing and photo-documenting administration techniques, and (b) experimental data on doses to thermoluminescent dosimeters (TLDs) on fingers of phantom hands holding syringes, and on syringes, with radionuclides in the syringes in each case. Actual exposure data for I-131 and Lu-177 were obtained in field studies. Variations in handling and administration techniques were identified. Dose rates measured using TLDs on the surface of loaded syringes were adjusted for differences in electronic stopping power, absorption coefficients, and attenuation between dosimeters and tissue to estimate dose-to-skin averaged over 1 cm 2 at 7 mg cm -2 depth for Y-90, Tc-99m, I-131, and Lu-177. Dose rate coefficients to the skin, if in contact with the syringe wall, were 89, 1.9, 3.8, and 0.41 microSv s -1 per 37 MBq (1 mCi) for Y-90, Tc-99m, I-131, and Lu-177, respectively. For dose reduction, when using Y-90 the importance was clearly indicated of (a) avoiding direct contact with syringes containing RABs, if practical, and (b) using a beta-particle shield on the syringe. In using a syringe for injection, doses can best be approximated for the geometry studied by (a) wearing a finger dosimeter on the middle finger, toward the outside of the hand, on the hand operating the plunger, and (b) wearing finger dosimeters on the inner (palm) side of the finger on the hand that supports the syringe for energetic beta-particle emitters, such as Y-90 and Re-188

  19. Terapia antihipertensiva en enfermedad renal crónica

    Directory of Open Access Journals (Sweden)

    V. Rodrigo Tagle, Dr.

    2010-07-01

    Full Text Available La enfermedad renal crónica (ERC constituye una de las causas más frecuentes de hipertensión arterial (HTA secundaria. Existe una nueva clasificación de la ERC basada en la presencia de un daño estructural con o sin un deterioro de la velocidad de filtración glomerular (VFG. La prevalencia de la HTA varía principalmente según la magnitud de la VFG y la etiología de la enfermedad del parénquima renal. Los mecanismos hipertensógenos primordiales son: la retención de sodio e hipervolemia, y la activación del eje renina angiotensina aldosterona. La HTA es también un factor de progresión de la ERC. La terapia se basa en la restricción de sodio, diuréticos y bloqueadores del eje renina angiotensina. Consideraciones farmacológicas y clínicas son fundamentales para un efectivo uso de esta terapia. Los objetivos son la prevención cardiovascular y renal, a través de la obtención de determinados niveles de presión arterial (PA.

  20. Dosimetric contribution of the organs of the I123, I124 and I131 bio-kinetics in the dose estimate for euthyroid adults

    International Nuclear Information System (INIS)

    Vasquez, A. M.; Rojas, A. R.; Castillo, D. C.; Idrogo, C. J.; Flores, U. H.

    2011-10-01

    Using the formalism MIRD and the representation of Crysty-Eckerman for the thyroid adult, is demonstrated that the dosimetric contributions of source organs of the biokinetics of the radiopharmaceuticals I 123 , I 124 and I 131 (iodine) are not significant in the dose estimate. Therefore, the total absorbed dose by the gland is its auto-dose. Equally, the reported results do not present significant differences to the results found by the Marinelli scheme (auto-dose) for the thyroid represented by a sphere of 20 grams. (Author)

  1. The initial investigation of radiation dose rate at X-ray department and patients treating thyroid by I-131 at nuclear medicine department

    International Nuclear Information System (INIS)

    Nguyen Van Kinh; Vo Thanh Cuong

    2000-01-01

    Survey meter NSM 150 Fuji with detector Geiger Muller has been used to assess for average annual exposure dose which affect radiographer ≤ 2 mSv per year, the staff involved with Fluoroscopy ≤ 19 mSv per year. Dose rate in waiting area of patient is a range from 0.2 to 0.8 μSv/h. Patients who have been treated by radioiodine, may be only discharged when the remaining activity is 400.2 ±368.8 MBq. Radioactivity of I-131 and Tc-99m in the sewage system of hospital is 0.4x10 -11 Ci/l. (author)

  2. Clinical experience of 2-hour I-131 thyroid uptake significance in considering the radioiodine Graves' disease treatment dose: A retrospective study

    International Nuclear Information System (INIS)

    Al-Shammeri, I.; Al-Deen Mahmood, S.; Al-Mohannadi, S.; Ballani, N.

    2015-01-01

    Purpose: It has been noticed that Graves' disease patients with high turnover are likely to experience under dosage when calculating the radioiodine therapeutic dose. We aim to demonstrate our clinical experience of 2-h I-131 uptake% value in estimating the radioiodine dose for Graves' disease patients with rapid washout. Material and methods: We reviewed the medical records for 2080 Graves' disease patients who received radioiodine treatment(s). Patients were distinguished by 2-h I-131 thyroid uptake%: 249 patients (group I) exhibited a rapid washout (>25%), and 250 patients (group II control group) demonstrated normal uptake (6–15%); the age and sex were balanced for both groups. These cases were reviewed for the time taken to control the condition clinically (ideally 3 months is the time needed), the time taken to achieve hypothyroidism (average time is 6 months), and the number of repeated treatments for recurrent thyrotoxicosis or failure of treatment. Results: In 152/249 (61%) patients, the condition was not controlled in the 3 month period post treatment and subsequently they needed more frequent and closer follow up, as opposed to 47/250 patients (19%) in the control group-II. At 6 months, 119/249 (48%) patients in group-I had not achieved hypothyroidism, as opposed to 28/250 patients (11%) in group-II. Seventy-seven patients in group-I (31%) needed a second or third therapeutic dose, as opposed to 10/250 patients (4%) in group-II. Conclusion: We believe that a higher radioiodine dose with significant rapid washout in the thyroid gland of Graves' disease patients would give a greater treatment success rate. - Highlights: • We present our clinical experience of 2-h I-131 uptake% value in Graves' disease. • We reviewed records of hyperthyroid patients who received radioiodine treatment. • Two patients' groups were distinguished by normal and high 2-h I-131 uptake%. • The two groups showed different radioiodine treatment

  3. Efectividad de la terapia manual en pacientes con dismenorrea primaria

    OpenAIRE

    Mazoteras García, María Dolores

    2016-01-01

    La dismenorrea primaria (DP) debe considerarse como el desorden ginecológico crónico más doloroso en mujeres en edad reproductiva y debe ser considerado como un desorden multifactorial, se puede describir como un síndrome doloroso, sin causa orgánica objetiva, generalmente de tipo cólico en la parte inferior del abdomen que puede irradiar a la zona lumbar y a la pelvis y se pueden asociar síntomas como náuseas, diarrea, mareos, dolor de cabeza y vómitos; el dolor suele aparecer el primer día ...

  4. Análisis bibliométrico: la terapia de espejo como estrategia de intervención desde la terapia ocupacional en el ámbito clínico

    OpenAIRE

    Castro Alzate, Elvis Siprián; Aguía Rojas, Karen; Linares Murcia, Leidy Vanessa; Yanquén Castro, Laura; Reyes Villanueva, Vanessa

    2016-01-01

    Objetivo: Determinar la evidencia científica, a nivel nacional e internacional, sobre el uso de la terapia de espejo como herramienta de intervención, desde terapia ocupacional, en el área clínica; esto con el propósito de ofrecer soporte teórico para la implementación de esta estrategia en la práctica profesional. Materiales y métodos. Se realizó un estudio descriptivo donde se utilizó como estrategia de búsqueda descriptores de ciencias de la salud (DECS), tales como 'neuronas en espejo', '...

  5. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood

    Directory of Open Access Journals (Sweden)

    Melanie Metallo

    2016-01-01

    Full Text Available Introduction. Differentiated thyroid cancer (DTC is rare and confers good prognosis. Long-term health related quality of life (HRQoL and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I131 before age of 25 years. Results. Forty-five of 61 patients (74% responded to the survey. Cumulative I131 activity was ≤3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 ± 5.2 years for the group ≤ 3.85 GBq versus 16.9 ± 11.6 years for the group > 3.85 GBq (P 3.85 GBq and 10 in patients from the group ≤ 3.85 GBq. Frequency of miscarriages was of 17% (group > 3.85 GBq and 10% (group ≤ 3.85 GBq with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.

  6. The standardization methods of radioactive sources (125I, 131I, 99mTc, and 18F) for calibrating nuclear medicine equipment in Indonesia

    International Nuclear Information System (INIS)

    Wurdiyanto, G; Candra, H

    2016-01-01

    The standardization of radioactive sources ( 125 I, 131 I, 99m Tc and 18 F) to calibrate the nuclear medicine equipment had been carried out in PTKMR-BATAN. This is necessary because the radioactive sources used in the field of nuclear medicine has a very short half-life in other that to obtain a quality measurement results require special treatment. Besides that, the use of nuclear medicine techniques in Indonesia develop rapidly. All the radioactive sources were prepared by gravimetric methods. Standardization of 125 I has been carried out by photon- photon coincidence methods, while the others have been carried out by gamma spectrometry methods. The standar sources are used to calibrate a Capintec CRC-7BT radionuclide calibrator. The results shows that calibration factor for Capintec CRC-7BT dose calibrator is 1,03; 1,02; 1,06; and 1,04 for 125 I, 131 I, 99m Tc and 18 F respectively, by about 5 to 6% of the expanded uncertainties. (paper)

  7. The standardization methods of radioactive sources (125I, 131I, 99mTc, and 18F) for calibrating nuclear medicine equipment in Indonesia

    Science.gov (United States)

    Wurdiyanto, G.; Candra, H.

    2016-03-01

    The standardization of radioactive sources (125I, 131I, 99mTc and 18F) to calibrate the nuclear medicine equipment had been carried out in PTKMR-BATAN. This is necessary because the radioactive sources used in the field of nuclear medicine has a very short half-life in other that to obtain a quality measurement results require special treatment. Besides that, the use of nuclear medicine techniques in Indonesia develop rapidly. All the radioactive sources were prepared by gravimetric methods. Standardization of 125I has been carried out by photon- photon coincidence methods, while the others have been carried out by gamma spectrometry methods. The standar sources are used to calibrate a Capintec CRC-7BT radionuclide calibrator. The results shows that calibration factor for Capintec CRC-7BT dose calibrator is 1,03; 1,02; 1,06; and 1,04 for 125I, 131I, 99mTc and 18F respectively, by about 5 to 6% of the expanded uncertainties.

  8. Evaluation of the absorbed dose during studies of the renal function due to I123 / I131 (hippuran) and In111 (DTPA)

    International Nuclear Information System (INIS)

    Vasquez, M.; Castillo, C.; Sarachaga, R.; Rojas, R.; Zelada, L.; Melendez, J.; Gomez, M.; Diaz, E.

    2014-08-01

    Using the methodology MIRD and representation Cristy-Eckerman for kidneys, bladder, and whole body as organs of the bio-kinetics of I 123 / I 131 (hippuran) and the In 111 (D PTA), the absorbed dose for studies of the renal function of adults due to the I 123 is 0,0071 mGy/MBq where 88.16% corresponds to its auto-dose and 11,96% to the organs of their bio-kinetics; while for the I 131 their dose is 0,032 mGy/MBq where 95,03% corresponds to its auto-dose and 4,97% to the organs of their bio-kinetics. For the In 111 their dose is 0,0168 mGy/MBq where 71,68% corresponds to their auto-dose and 28,32% to the organs of their bio-kinetics. In all the cases the dosimetric contributions of the organs of the bio-kinetics (whole body and urinary bladder) are very significant, and this fundamentally is due to the photons of the whole body. (Author)

  9. Estimation of ingestion dose due to I-131 in the initial month by using food-monitoring data after the Fukushima nuclear disaster in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Ichiro [National Institute of Public Health, Department of Environmental Health, Wako, Saitama (Japan)

    2012-11-15

    The committed equivalent dose to the thyroid caused by I-131 and the effective dose caused by I-131, Cs-134 and Cs-137 due to ingestion immediately after the accidental releases following the Fukushima nuclear disaster in March 2011 were estimated retrospectively by using measured food data. A food monitoring dataset provided by the Ministry of Health, Labour and Welfare (MHLW) up to April 18, 2011 (N=1,752) was used for this study. Information on food consumption by 99 food categories was made available by using the original data of the Japanese National Food Consumption Survey, which was conducted in 2009 (N=9,942). Food concentration every 4 days and food consumption in each food category was randomly picked up (N=100,000). The levels of radioactive iodine and cesium were summed for one month and then converted to equivalent doses to the thyroid and effective doses. These doses in the first month after the Fukushima nuclear power plant accident were evaluated by using the food monitoring dataset provided by the MHLW. Assuming that food was randomly extracted from monitored food samples and food restrictions were fully implemented, the 90%tile of the equivalent doses to the thyroid and the effective doses in 1- to 6-year-old children were estimated to be around 1 mSv and 0.07 mSv, respectively. Several different methods should be considered to reduce limitations of this estimation. (author)

  10. Terapia nutricional e sepse neonatal

    Directory of Open Access Journals (Sweden)

    Brunnella Alcantara Chagas de Freitas

    2011-12-01

    Full Text Available O objetivo do presente artigo é revisar a literatura acerca dos conhecimentos atuais relativos à terapia nutricional - enteral e parenteral - para os recém-nascidos pré-termo, principalmente os de muito baixo peso, destacando seu efeito protetor na sepse neonatal e na enterocolite necrosante. As diferentes modalidades de alimentação do recém-nascido prematuro - especialmente para aqueles de muito baixo peso - e seu efeito protetor na diminuição de complicações (mormente as infecciosas foram analisadas. A utilização preferencial do leite materno na nutrição enteral, o controle das ofertas energético-protéicas, o início precoce da nutrição enteral mínima, a introdução precoce da alimentação parenteral - nas primeiras 24 horas - e a utilização dos imunonutrientes que tenham estudos suficientes para fundamentar sua indicação podem se constituir em boas diretrizes adjuvantes na prevenção da sepse neonatal e da enterocolite necrosante. Sem embargo, percebe-se a necessidade de mais estudos - preferencialmente multicêntricos, controlados e randomizados - para esclarecer o papel protetor da nutrição no RNPT, não somente na prevenção de infecções, mas também para auxiliar o desenvolvimento neural e a prevenção de consequências deletérias futuras.

  11. Normalization of lymphocyte count after high ablative dose of I-131 in a patient with chronic lymphoid leukemia and secondary papillary carcinoma of the thyroid: case report; Normalizacao da contagem de linfocitos apos dose ablativa de I-131 em um paciente com leucemia linfoide cronica e carcinoma papilifero da tireoide: relato de caso

    Energy Technology Data Exchange (ETDEWEB)

    Thom, Anneliese Rosmarie Gertrud Fischer; Hamerschlak, Nelson; Osawa, Akemi; Santos, Fabio Pires de Souza; Pasqualin, Denise da Cunha; Wagner, Jairo; Yamaga, Lilian Yuri Itaya; Cunha, Marcelo Livorsi da; Campos Neto, Guilherme de Carvalho; Funari, Marcelo Buarque de Gusmao, E-mail: afthom@einstein.br [Hospital Israelita Albert Einstein, Sao Paulo, SP (Brazil); Teles, Veronica Goes [Sociedade Brasileira de Diabetes, Sao Paulo, SP (Brazil)

    2014-07-01

    The authors report the case of a 70-year-old male patient with chronic lymphoid leukemia who presented subsequently a papillary carcinoma of the thyroid with metastases to regional lymph nodes. The patient was treated with surgical thyroidectomy with regional and cervical lymph node excision and radioiodine therapy (I-131). The protocolar control scintigraphy 4 days after the radioactive dose showed I-131 uptake in both axillae and even in the inguinal regions. PET/CT showed faint FDG-F-18 uptake in one lymph node of the left axilla. An ultrasound guided fine needle biopsy of this lymph node identified by I-131 SPECT/CT and FDG-F-18 PET/CT revealed lymphoma cells and was negative for thyroid tissue and thyroglobulin content. The sequential blood counts done routinely after radiation treatment showed a marked fall until return to normal values of leucocytes and lymphocytes (absolute and relative), which were still normal in the last control 19 months after the radioiodine administration. Chest computed tomography showed a decrease in size of axillary and paraaortic lymph nodes. By immunohistochemistry, cells of the lymphoid B lineage decreased from 52% before radioiodine therapy to 5% after the procedure. The authors speculate about a possible sodium iodide symporter expression by the cells of this lymphoma, similar to some other non-thyroid tumors, such as breast cancer cells. (author)

  12. Our experience of high dose I-131 therapy in 75 patients with well differentiated carcinoma thyroid followed up over 5 years

    International Nuclear Information System (INIS)

    Dougall, P.; Kumar, A.; Ashok, P.; Chinwan, B.P.; Khan, B.; Pandey, D.; Joshi, N.D.

    2005-01-01

    Thyroid cancer is the most common endocrine malignancy. The epidemiology of thyroid cancer is variable, depending on the geographic location of the patient population. Well differentiated thyroid cancer (WTC), is responsive to high dose I-131 treatment, and is the most accepted form of therapy, even though the dose administered for ablation of residual thyroid tissue maybe controversial. At our centre, 75 patients of WTC, mean age 42.4 years, 22 males and 53 females (M:F 1:2.4), were treated with high dose oral I-131 therapy with a Total Mean Dose (TMD) of 263.6 mCi, 4 - 6 weeks post thyroidectomy. They were followed up over a period of 6 years. Twenty ( 26.7%) patients had follicular cancer (FC), 47 (62.7%) papillary cancer (PC) and 8 (10.7%) were mixed (MC), on histopathology, at presentation. 38 (50.7%) patients had only residual thyroid tissue (RTT) on I-131 whole body bone scan (WBS) and 37 (49.3%) presented with metastatic disease (MD) at the time of therapy. Of the 37 patients with MD, 21 (56.8%) had metastases to the lymph nodes, 6 (16.2%) to the lungs, 4 (10.8%) to bone, 3 (8.1%) to bone and lung, and 4 (10.8%) to lung plus lymph nodes. Twenty-three patients (7 FC , 13 - PC and 3 MC; 6 RTT, 17 - MD) , received more than one dose of I-131 with a TMD of 422.7 mCi (Range 88 1590 mCi ). 52 patients (13 FC, 34 PC, 5 MC; 20 MD and 32 RTT) received a single TMD of 104.4 (Range 39.5 219 mCi). On follow-up, 3 patients of FC with MD (2 lung metastasis and 1 with extensive lymph node metastasis), died within 3 months 2 years of therapy. 3 patients of MD (2 FC, 1-MC; 2 bone metastasis and 1 bone with lung metastasis) died after 5 .5 years, Of the 6 patients who died, 5 were FC and only 1 was MC. 2 patients with MD to lungs and bone had received a single dose and were lost to follow up. All patients with PC and FC with only RTT, were surviving at the end of 5 years. None of the patients with MD to lymph nodes died at the end of 5 years, either receiving single or

  13. Terapia cognitivo-comportamental da fobia social

    OpenAIRE

    Ito,Lígia M; Roso,Miréia C; Tiwari,Shilpee; Kendall,Philip C; Asbahr,Fernando R

    2008-01-01

    OBJETIVO: Este artigo revisa aspectos relevantes da fobia social e os estágios de tratamento através da terapia cognitivo-comportamental em crianças, adolescentes e adultos. MÉTODO: A partir do banco de dados Medline, realizou-se revisão da literatura publicada a respeito do tratamento da fobia social por meio da terapia cognitivo-comportamental. RESULTADOS: Revisão da literatura sugere que a fobia social é uma condição prevalente e crônica, caracterizada por inibição social e timidez excessi...

  14. V Jornadas de actualización en terapia ocupacional: Formación continuada en terapia ocupacional

    OpenAIRE

    Asensio, Carmen; García Lemos, C.; Viedma, María José de; Pérez Corrales, Jorge; Sánchez Cabeza, Ángel; Pascual Agudo, Elisa; Santos, Francisco de los

    2014-01-01

    V Jornadas de actualización en terapia ocupacional: Formación continuada en terapia ocupacional, celebradas en la Universidad Rey Juan Carlos campus de Alcorcón en 2014. Fisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física

  15. Terapias y Actividades asistidas por animales: una buena herramienta en la Educación Infantil.

    OpenAIRE

    García Meneses, Berta

    2015-01-01

    Este es un trabajo fin de grado el cual presenta la posibilidad de realizar terapias y actividades de asistencia con animales, tanto para niños normales, como para niños con alguna dificultad, ayudándonos siempre de las asociaciones de la comunidad. This is a Final Grade Work, that I describing the possibility of the therapy and activities, for different children of the school, that present someone problems or not. This Final Grade Work, it´s help for many association of this community. ...

  16. DANO OCUPACIONAL NA UNIDADE DE TERAPIA INTENSIVA NEONATAL: A PERCEPÇÃO DA ENFERMEIRA

    OpenAIRE

    MARIA ALVANI DIAS PEDROZA; ANTONIA DO CARMO SOARES CAMPOS; MÁRCIA MARIA COELHO OLIVEIRA

    2006-01-01

    Se trata de estudio cuantitativo, exploratorio y descriptivo, con el objetivo de conocer la percepción de las enfermeras con respecto a la influencia del desempeño en la asistencia de enfermería y en el ambiente laboral. Tuvo por escenario la Unidad de Terapia Intensiva Neonatal (UTIN) de una maternidad escuela, en Fortaleza-CE. Recogimos los datos entre agosto y septiembre de 2004 a través de un cuestionario estructurado en parte, aplicado a 24 enfermeras activas. Verificamos que la mayor co...

  17. Aportaciones de la etnografía doblemente reflexiva en la construcción de la terapia ocupacional desde una perspectiva intercultural

    OpenAIRE

    Inmaculada Zango Martín; Pedro Moruno Millares

    2013-01-01

    En el ámbito de la terapia ocupacional, como consecuencia de los procesos de globalización, hay un interés creciente por aspectos relativos a la cultura y sus relaciones con la salud. El desarrollo de la terapia ocupacional en contextos multiculturales transciende el cuestionamiento terminológico para ahondar y perfilar nuevas directrices relacionadas con la construcción y consolidación del conocimiento. De este modo, este artículo plantea el análisis crítico de los principales fundamentos te...

  18. Pacientes vítimas de politrauma com insuficiência renal aguda na unidade de terapia intensiva Pacientes víctimas de politrauma con insuficiência renal aguda en la unidad de cuidados intensivos Patient victim of polytrauma with acute renal failure in the intensive care unit

    Directory of Open Access Journals (Sweden)

    Rita de Cássia Helú Mendonça Ribeiro

    2008-01-01

    Full Text Available OBJETIVOS: Identificar as características de pacientes portadores de insuficiência renal aguda (IRA, vítimas de politrauma, internados em uma unidade de terapia intensiva (UTI. MÉTODOS: Foi realizada uma análise retrospectiva de 357 prontuários de portadores de IRA, no período de 2002 a 2003, com creatinina sérica de 1,8 a 4 mg/dl. Destes pacientes internados na UTI, 10,6% eram vítimas de politrauma. RESULTADOS: Dos 38 (10,6% pacientes portadores de IRA e vítimas de politrauma, 78,9% eram do sexo masculino; 47,3% tinham idade entre 16 e 45 anos; 84,3% apresentaram oligúria; 92,1% não receberam tratamento para IRA durante a internação; 50% permaneceram de um a cinco dias internados na UTI; 47,3% não apresentaram nenhuma doença de base e a mortalidade ocorreu em 50% desta amostra. CONCLUSÃO: Concluiu-se que a monitorização diária da função renal das vítimas de politrauma é um cuidado importante para evitar as complicações da IRA e a respectiva mortalidade.OBJETIVOS: Identificar las características de pacientes portadores de insuficiencia renal aguda (IRA, víctimas de politrauma, internados en una unidad de cuidados intensivos (UCI. MÉTODOS: Se llevó a cabo un análisis retrospectivo de 357 historias clínicas de portadores de IRA, en el período de 2002 a 2003, con creatinina sérica de 1,8 a 4 mg/dl. De estos pacientes internados en la UCI, el 10,6% eram víctimas de politrauma. RESULTADOS: De los 38 (10,6% pacientes portadores de IRA y víctimas de politrauma, el 78,9% eran del sexo masculino; el 47,3% tenían edades entre 16 y 45 años; el 84,3% presentaron oliguria; el 92,1% no recibieron tratamiento para IRA durante el internamiento; el 50% permanecieron de uno a cinco días internados en la UCI; el 47,3% no presentaron ninguna enfermedad de base y la mortalidad ocurrió en el 50% de esta muestra. CONCLUSIÓN: el monitoreo diario de la función renal de las víctimas de politrauma es un cuidado importante para

  19. Evaluation of radiation exposure of workers caring for the patient after administration of radionuclide I-131 based on the Monte Carlo

    International Nuclear Information System (INIS)

    Hudzietzova, J.; Sabol, J.; Fueloep, M.

    2013-01-01

    In the paper using the Monte Carlo method ( code MCNPX) were calculated absorbed doses in organs caregivers, from which thereafter was set the value of the equivalent dose in these organs by appropriate formulas and then effective doses in selected geometries using protective shielding devices. The results show that using of shielding aprons equivalent of 1 mm of lead will reduce the exposure of workers caring for patients after administration of the radionuclide I-131 by about 30%. If the caregiver without protective shielding aprons is located between two patients, the gamma rays will be reduced by about 18% due to averted body of caregiver, while the worker's personal dosimeter located at the chest will register approximately 40% lower value of personal dose equivalent. (authors)

  20. CULTURA DE SEGURANÇA DO PACIENTE EM TERAPIA INTENSIVA: RECOMENDAÇÕES DA ENFERMAGEM

    Directory of Open Access Journals (Sweden)

    Janeide Freitas de Mello

    2013-01-01

    Full Text Available Estudio cuantitativo, de tipo investigativo, transversal y comparativo que tuvo por objeto sistematizar las recomendaciones de enfermería sobre la seguridad del paciente en dos Unidades de Terapia Intensiva adulta de la Grande Florianópolis-SC, Brasil, en 2011. Resultó de la respuesta a una pregunta cualitativa aplicada con el Hospital Survey on Patient Safety Culture para 97 profesionales, con una tasa de respuesta del 93,8% correspondiente a 91 profesionales, y obtuvo 267 recomendaciones, clasificadas de acuerdo con las dimensiones del instrumento utilizado. Hubo un mayor número de recomendaciones para las dimensiones: aprendizaje organizacional y la mejora continua, con sugerencias envolviendo a la capacitación y al entrenamiento; personal en relación con la cuestión cuantitativa; y la percepción general de la seguridad, indicándose la mejoría de los procedimientos, los procesos y el apoyo de la gestión hospitalaria, dando énfasis a la mejoría de los recursos materiales y equipamientos. Destacadas por otros estudios, estas recomendaciones son esenciales para la promoción de la seguridad del paciente en las Unidades de Terapia Intensiva estudiadas.

  1. Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients

    Directory of Open Access Journals (Sweden)

    Gül Ege Aktaş

    2015-10-01

    Full Text Available Objective: Geriatric patient population has special importance due to particular challenges. In addition to the increase in incidence of toxic nodular goiter (TNG with age, it has a high incidence in the regions of low-medium iodine intake such as in our country. The aim of this study was to evaluate the overall outcome of high fixed dose radioiodine (RAI therapy, and investigate the particular differences in the geriatric patient population. Methods: One hundred and three TNG patients treated with high dose I-131 (370-740 MBq were retrospectively reviewed. The baseline characteristics; age, gender, scintigraphic patterns and thyroid function tests before and after treatment, as well as follow-up, duration of antithyroid drug (ATD medication and achievement of euthyroid or hypothyroid state were evaluated. The patient population was divided into two groups as those=>65 years and those who were younger, in order to assess the effect of age. Results: Treatment success was 90% with single dose RAI therapy. Hyperthyroidism was treated in 7±7, 2 months after RAI administration. At the end of the first year, overall hypothyroidism rate was 30% and euthyroid state was achieved in 70% of patients. Age was found to be the only statistically significant variable effecting outcome. A higher ratio of euthyroidism was achieved in the geriatric patient population. Conclusion: High fixed dose I-131 treatment should be preferred in geriatric TNG patients in order to treat persistent hyperthyroidism rapidly. The result of this study suggests that high fixed dose RAI therapy is a successful modality in treating TNG, and high rates of euthyroidism can be achieved in geriatric patients.

  2. Multiple model testing using Chernobyl fallout data of I-131 in forage and milk and Cs-137 in forage, milk, beef and grain. Pt. 2

    International Nuclear Information System (INIS)

    1991-03-01

    BIOMOVS is an international study for testing and validating model predictions of the transfer of radionuclides and rare stable elements through the biosphere. The BIOMOVS A4 scenario was designed to test model prediction of the transfer of I-131 and Cs-137 from the atmosphere via pasture vegetation to milk and of the Cs-137 transfer from air to beef (via vegetation) and grain. This document is an appendix to the A4 report. It includes tables and figures of time-integrated results, a summary of a statistical analysis of time-dependent and representative figures of time-dependent results. The quantities to be predicted in this scenario were wet, dry and total deposition (Bq m -2 ) of I-131 and Cs-137, contamination of vegetation (Bq kg -1 d.w.), milk (Bq L -1 ), beef and grain (Bq kg -1 ). While with steady state models only time-integrated results for vegetation, milk and beef could be calculated, these quantities also were requested as time-series from users of dynamic models. A detailed description of the participating models is given in Appendix 3, while all collected observations are documented in Appendix 2 of the A4 report. A diskette with all observed data can be obtained from the Swedish National Institute of Radiation Protection, SSI, or from Harry Koehler, IAEA, Vienna, Austria. For time-integrated P/Os, graphs for all locations and all models and sometimes subsets of these are provided. For time-series, graphs are enclosed for the observations and some model results. These values are calculated across locations and across models for time-integrated predictions and for the P/O of entire time-series and subsets of these for the time-dependent predictions. (au)

  3. I-131 Treatment of Graves' Disease in an Unsuspected First Trimester Pregnancy; the Potential for Adverse Effects on the Fetus and a Review of the Current Guidelines for Pregnancy Screening

    Directory of Open Access Journals (Sweden)

    Phuong Tran

    2010-01-01

    Full Text Available Graves' disease is a thyroid-specific autoimmune disorder in which the body makes antibodies to the thyroid-stimulating hormone receptor leading to hyperthyroidism. Therapeutic options for the treatment of Graves' disease include medication, radioactive iodine ablation, and surgery. Radioactive iodine is absolutely contraindicated in pregnancy as exposure to I-131 to the fetal thyroid can result in fetal hypothyroidism and cretinism. Here we describe a case of a female patient with recurrent Graves' disease, who inadvertently received I-131 therapy when she was estimated to be eight days pregnant. This was despite the obtaining of a negative history of pregnancy and a negative urine pregnancy test less than 24 hours prior to ablation. At birth, the infant was found to have neonatal Graves' disease. The neonatal Graves' disease resolved spontaneously. It was suspected that the fetal thyroid did not trap any I-131 as it does not concentrate iodine until 10 weeks of gestation.

  4. I-131 Treatment of Graves' Disease in an Unsuspected First Trimester Pregnancy; the Potential for Adverse Effects on the Fetus and a Review of the Current Guidelines for Pregnancy Screening

    Directory of Open Access Journals (Sweden)

    Barrett Mark

    2010-03-01

    Full Text Available Graves' disease is a thyroid-specific autoimmune disorder in which the body makes antibodies to the thyroid-stimulating hormone receptor leading to hyperthyroidism. Therapeutic options for the treatment of Graves' disease include medication, radioactive iodine ablation, and surgery. Radioactive iodine is absolutely contraindicated in pregnancy as exposure to I-131 to the fetal thyroid can result in fetal hypothyroidism and cretinism. Here we describe a case of a female patient with recurrent Graves' disease, who inadvertently received I-131 therapy when she was estimated to be eight days pregnant. This was despite the obtaining of a negative history of pregnancy and a negative urine pregnancy test less than 24 hours prior to ablation. At birth, the infant was found to have neonatal Graves' disease. The neonatal Graves' disease resolved spontaneously. It was suspected that the fetal thyroid did not trap any I-131 as it does not concentrate iodine until 10 weeks of gestation.

  5. An oncolytic adenovirus regulated by a radiation-inducible promoter selectively mediates hSulf-1 gene expression and mutually reinforces antitumor activity of I131-metuximab in hepatocellular carcinoma.

    Science.gov (United States)

    Zhang, Yan; Fang, Lin; Zhang, Quan'an; Zheng, Qin; Tong, Jinlong; Fu, Xiaohui; Jiang, Xiaoqing; Su, Changqing; Zheng, Junnian

    2013-06-01

    Gene therapy and antibody approaches are crucial auxiliary strategies for hepatocellular carcinoma (HCC) treatment. Previously, we established a survivin promoter-regulated oncolytic adenovirus that has inhibitory effect on HCC growth. The human sulfatase-1 (hSulf-1) gene can suppress the growth factor signaling pathways, then inhibit the proliferation of cancer cells and enhance cellular sensitivity to radiotherapy and chemotherapy. I(131)-metuximab (I(131)-mab) is a monoclonal anti-HCC antibody that conjugated to I(131) and specifically recognizes the HAb18G/CD147 antigen on HCC cells. To integrate the oncolytic adenovirus-based gene therapy and the I(131)-mab-based radioimmunotherapy, this study combined the CArG element of early growth response-l (Egr-l) gene with the survivin promoter to construct a radiation-inducible enhanced promoter, which was used to recombine a radiation-inducible oncolytic adenovirus as hSulf-1 gene vector. When I(131)-mab was incorporated into the treatment regimen, not only could the antibody produce radioimmunotherapeutic effect, but the I(131) radiation was able to further boost adenoviral proliferation. We demonstrated that the CArG-enhanced survivin promoter markedly improved the proliferative activity of the oncolytic adenovirus in HCC cells, thereby augmenting hSulf-1 expression and inducing cancer cell apoptosis. This novel strategy that involved multiple, synergistic mechanisms, including oncolytic therapy, gene therapy and radioimmunotherapy, was demonstrated to exert an excellent anti-cancer outcome, which will be a promising approach in HCC treatment. Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  6. Factores que Favorecen y se Interponen en el Establecimiento de la Alianza Terapéutica en Terapia de Familia y Pareja

    Directory of Open Access Journals (Sweden)

    CAMILA BERMÚDEZ

    2013-01-01

    Full Text Available La alianza terapéutica (AT es uno de los factores comunes que ha recibido mayor soporte empírico en relación con el resultado terapéutico. En terapia de familia y pareja resulta más complejo desarrollar la AT que en la individual. Mediante entrevistas semiestructuradas a consultantes y terapeutas, se exploraron los factores que ellos relacionaban con el desarrollo de la AT. El análisis de contenido mostró que la participación voluntaria y comprometida de los consultantes, el asumir responsabilidad por el problema, el confiar en la terapia, el desear cambiar y la congruencia entre intervención y expectativas hacia la terapia, entre otros factores, favorecen la AT.

  7. Terapia dialéctico conductual para el trastorno de personalidad límite

    Directory of Open Access Journals (Sweden)

    Irene de la Vega

    2013-06-01

    Full Text Available La terapia dialéctico conductual (TDC es una terapia psicológica de tercera generación desarrollada por Marsha Linehan (1993a, 1993b para tratar específicamente los síntomas característicos del trastorno límite de la personalidad: inestabilidad afectiva, trastorno de identidad, impulsividad y dificultades en las relaciones sociales. La TDC parte de un modelo biosocial del trastorno límite y combina técnicas cognitivo conductuales con aproximaciones zen y budistas basadas en la aceptación de la realidad tal como se presenta. El tratamiento consiste en un entrenamiento en habilidades, psicoterapia individual y atención en crisis y es llevado a cabo por un equipo coordinado de profesionales que ejercen distintas funciones. La TDC cuenta con estudios de eficacia y se está aplicando con éxito a otras poblaciones de pacientes con elevada impulsividad.

  8. Terapias complementarias e integrativas como intervención enfermera en los diferentes estadios del proceso reproductivo femenino

    OpenAIRE

    Fernández, Ana Belén

    2018-01-01

    Las mujeres siempre han cuidado de la salud de sus hijos y familiares con los elementos que la naturaleza les ha ofrecido: las plantas (fitoterapia, aromaterapia), el sol (helioterapia), el agua (hidroterapia), y hasta con sus propias manos como único recurso, y hasta con sus propias manos.La enfermería ha aprovechado las terapias naturales como instrumentos complementarios de los cuidados enfermeros.La clasificación que utiliza el Colegio Oficial de Enfermeras y Enfermeros de Barcelona de di...

  9. Foto personali e foto di famiglia come strumento per la terapia. Il “Come, Cosa e Perché” delle tecniche di FotoTerapia

    Directory of Open Access Journals (Sweden)

    Judy Weiser

    2010-12-01

    Full Text Available L’articolo spiega come e perché, l’utilizzo delle foto personali e quelle di famiglia delle persone in terapia durante il loro trattamento (“Tecniche di FotoTerapia” possa aumentare e approfondire tale processo, e migliorare la qualità dei risultati terapeutici. Si descrive come le foto creino un ponte in grado di raggiungere aree profonde del vissuto del cliente dove le parole non possono arrivare – fornendo quindi un eccellente mezzo per esaminare ed esplorare i sentimenti con il minimo dell’interferenza e delle difese cognitive. Basato sul principio che le fotografie presentano accanto ai dettagli visivi un contenuto emotivo, questo articolo mostra come il terapeuta formato nelle Tecniche di FotoTerapia possa usare le foto personali e quelle di famiglia del cliente per evocare ricordi, richiamare sentimenti, riconnettere pensieri, nascondere segreti, e portare alla luce il passato con nuove modalità. Si mostra come le Tecniche di FotoTerapia siano basate sul fatto che tutte le fotografie parlano il linguaggio metaforico e simbolico dell’inconscio, senza usare le parole, e quindi ogni immagine fotografica è in grado, indipendentemente dalla modalità preferita dal terapeuta, di raggiungere informazioni e sentimenti precedentemente bloccati o fortemente difesi. Dopo l’” Introduzione” e le Sezioni relative alle “Arti (e Arte Terapia” e “Fotografie (e Fotografia” che propongono le basi teoriche delle tecniche di FotoTerapia, l’articolo procede da una rassegna generale dell’“Uso delle Fotografie nella Pratica Terapeutica” a una spiegazione più dettagliata della “Cornice di Lavoro delle Tecniche di FotoTerapia”, discutendo i principi e le specifiche applicazioni di ogni tecnica, da usare singolarmente o in combinazione con le altre. È inoltre inclusa una comparazione tra le tecniche di “FotoTerapia” e le analoghe applicazioni sia della “Foto Arte Terapia” che della “Fotografia Terapeutica

  10. [F-18-fluordeoxyglucose positron emission tomography on patients with differentiated thyroid cancer who present elevated human serum thyroglobulin levels and negative I-131 whole body scan].

    Science.gov (United States)

    Ruiz Franco-Baux, J V; Borrego Dorado, I; Gómez Camarero, P; Rodríguez Rodríguez, J R; Vázquez Albertino, R J; Navarro González, E; Astorga Jiménez, R

    2005-01-01

    This study aimed to evaluate the role of Fluorine-18-fluorodeoxyglucose positron emission tomography (PET-FDG) in patients with elevated serum thyroglobulin (hTg) levels where thyroid cancer tissue does not concentrate radioiodine, rendering false-negative results on I-131 scanning. Whole-body PET imaging using FDG was performed in 54 patients (37 female, 17 male) aged 17-88 years: 45 with papillary tumors and 9 with follicular tumors who were suspected of having recurrent thyroid carcinoma due to elevated thyroglobulin levels (hTg > 2 ng/ml) under thyroid-stimulating hormone (TSH > or = 30 microIU/ml) in whom the iodine scan was negative. All whole body scans were obtained with diagnostic doses (185 MBq). Whole body PET imaging was performed in fasting patients following i.v. administration of 370 MBq FDG while the patients were receiving full thyroid hormone replacement. Before PET, 99mTc methoxyisobutylisonitrile scintigraphy (99mTc-MIBI) was done in 14 patients and morphologic imaging in 26 by CT scan. Positive PET results confirmed the presence of hypermetabolic foci in 25/54 patients (46.29 %). Positive findings were found for PET-FDG in patients with hTg levels higher than 10 ng/ml receiving full thyroid hormone replacement. 99mTc-MIBI demonstrated lesions in 7/14 patients (50 %). PET-FDG and 99mTc-MIBI had congruent positive results in 4/7 patients. All the lesions found by CT were detected by PET-FDG, while recurrent disease was found in 12/21 patients with previous negative CT. These results suggest that PET-FDG seems to be a promising tool in the follow-up of thyroid cancer and should be considered in patients suffering from differentiated thyroid cancer with suspected recurrence and/or metastases by elevated thyroglobulin levels, and negative I-131 whole body scans. PET-FDG might be more useful at hTg levels > 10 ng/ml.

  11. A practical guideline for the release of patients treated by I-131 based on Monte Carlo dose calculations for family members

    International Nuclear Information System (INIS)

    Han, Eun Young; Lee, Choonsik; Mcguire, Lynn; Bolch, Wesley E

    2014-01-01

    We recently published effective doses per time-integrated activity (mSv MBq −1  s −1 ) for paediatric and adult family members exposed to an adult patient released from hospital following I-131 therapy. In the present study, we intend to provide medical physicists with a methodology to estimate family member effective dose in daily clinical practice because the duration of post-radiation precautions for the patient–family member exposure scenario has not been explicitly delineated based on the effective dose. Four different exposure scenarios are considered in this study including (1) a patient and a family member standing face to face, (2) a patient and a family member lying side by side, (3) an adult female patient holding a newborn child to her chest and (4) a one-year-old child standing on the lap of an adult female patient following her I-131 therapy. The results of this study suggest that an adult female hyperthyroidism (HT) patient who was administered with 740 MBq should keep a distance of 100 cm from a 15-year-old child for six days and the same distance from other adults for seven days. The HT female patient should avoid holding a newborn against her chest for at least 16 days following hospital discharge, and a female patient treated with 5550 MBq for differentiated thyroid cancer should not hold her newborn child for at least 15 days following hospital discharge. This study also gives dose coefficients allowing one to predict age-specific effective doses to family members given the measured dose rate (mSv h −1 ) of the patient. In conclusion, effective dose-based patient release criteria with a modified NRC two-component model provide a site medical physicist with less restrictive and age-specific radiation precaution guidance as they fully consider a patient’s iodine biokinetics and photon attenuation within both the patient and the exposed family members. (note)

  12. Terapia gênica Gene therapy

    Directory of Open Access Journals (Sweden)

    Nance Beyer Nardi

    2002-01-01

    Full Text Available Terapia gênica é um procedimento médico que envolve a modificação genética de células como forma de tratar doenças. Os genes influenciam praticamente todas as doenças humanas, seja pela codificação de proteínas anormais diretamente responsáveis pela doença, seja por determinar suscetibilidade a agentes ambientais que a induzem. A terapia gênica é ainda experimental, e está sendo estudada em protocolos clínicos para diferentes tipos de doenças. O desenvolvimento de métodos seguros e eficientes de transferência gênica para células humanas é um dos pontos mais importantes na terapia gênica. Apesar do grande esforço dirigido na última década para o aperfeiçoamento dos protocolos de terapia gênica humana, e dos avanços importantes na pesquisa básica, as aplicações terapêuticas da tecnologia de transferência gênica continuam ainda em grande parte teóricas. O potencial da terapia gênica é muito grande, devendo ainda causar grande impacto em todos os aspectos da medicina.Gene therapy is a medical intervention that involves modifying the genetic material of living cells to fight disease. Genes influence virtually every human disease, either by encoding for abnormal proteins, which are directly responsible for the disease, or by causing a susceptibility to environmental agents which induce it. Gene therapy is still experimental, and is being studied in clinical trials for many different types of diseases. The development of safe and effective methods of implanting normal genes into the human cell is one of the most important technical issues in gene therapy. Although much effort has been directed in the last decade toward improvement of protocols in human gene therapy, and in spite of many considerable achievements in basic research, the therapeutic applications of gene transfer technology still remain mostly theoretical. The potential for gene therapy is huge and likely to impact on all aspects of medicine.

  13. Cambios en la depresión y el sentimiento de soledad después de la terapia de la risa en adultos mayores internados

    Directory of Open Access Journals (Sweden)

    Ángela Quintero

    2015-03-01

    Conclusión. Se resalta la importancia que tiene la terapia de la risa en la disminución del grado de depresión en adultos mayores. Los resultados concuerdan con la afirmación de que el constructo de soledad es independiente del de depresión.

  14. I-124 PET/CT to Predict the Outcome of Blind I-131 Treatment in Patients with Biochemical Recurrence of Differentiated Thyroid Cancer : Results of a Multicenter Diagnostic Cohort Study (THYROPET)

    NARCIS (Netherlands)

    Kist, Jakob W.; de Keizer, Bart; van der Vlies, Manfred; Brouwers, Adrienne H.; Huysmans, Dyde A.; van der Zant, Friso M.; Hermsen, Rick; Stokkel, Marcel P. M.; Hoekstra, Otto S.; Vogel, Wouter V.

    Patients with suspected recurrence from differentiated thyroid carcinoma, based on an increased thyroglobulin (Tg) level and negative neck ultrasound (US), pose a clinical dilemma. Because standard imaging has a low yield identifying potential recurrence, blind I-131 treatment is often applied.

  15. A arteterapia no contexto da hospitalização pediátrica: O desenvolvimento da construção com sucata hospitalar La terapia a través del arte en el contexto de la hospitalización pediátrica: El desarrollo de la construcción con chatarra hospitalaria The art therapy in the context of the pediatric hospitalization: The development of the construction with hospital scrap

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Afonso Valladares

    2005-03-01

    intervenciones de la terapia a través del arte. Se trata de una investigación de abordaje cuasi-experimental, con 20 niños, distribuidos en dos grupos: grupo experimental (n=10 y grupo control (n=10. El análisis de los datos mostró que la terapia a través del arte fue eficaz en cuanto a las variables de evaluación del desempeño del quehacer tridimensional y de la utilización de los desechos hospitalarios de los niños hospitalizados. Se conluye que la terapia a través del arte, constituye un medio para canalizar de manera positiva las variables del desarrollo del niño hospitalizado y neutraliza los factores de orden afectivo que, naturalmente, surgen, mas allá de ofrecer espacios más saludables para el niño, a veces poco estimulados en el contexto de la hospitalización.Hospitalization may have negative effects on child development. It takes the child off her routine and prevents her from contacts with stimulating environments. Art therapy, a means of expression and creation, enlarges the child’s knowledge of the world and favors his/her cognitive, affectionate, physical and social development, and for this reason, it must be present in all children’s lives, particularly of those who are hospitalized. This work aimed at comparing the children’s three-dimensional performance and construction work using hospital scrap during their hospitalization, before and after art therapy intervention. It was proposed a quantitative approach with quasi experimental design that had a control group (n=9 and a group which was submitted to art therapy intervention (n=10. Results show that these interventions were effective in improving the children’s threedimensional performance and construction work using hospital scrap. Art therapy constituted a means to positively guide the hospitalized child’s development variables as well as to neutralize the naturally arising affection-related factors, in addition to exposing the child’s healthiest potentials that are seldom

  16. TERAPIA GÉNICA Y PRINCIPIOS ÉTICOS A TERAPIA GÊNICA E OS PRINCÍPIOS ÉTICOS GEN THERAPY AND ETHICAL PRINCIPLES

    Directory of Open Access Journals (Sweden)

    Eduardo Rodríguez Yunta

    2003-01-01

    Full Text Available La terapia génica constituye una forma de manipulación genética que trata de corregir o disminuir los efectos que ocasionan enfermedades de origen genético. Existen grandes esperanzas en el desarrollo de este tipo de terapia, sobre todo para enfermedades somáticas de origen genético que no tienen curación. Pero hay también numerosas dificultades técnicas que no están del todo resueltas. No se ha demostrado todavía eficacia clínica y se pueden producir daños irreversibles en el organismo. Por una parte, existe la necesidad de regular por medio de protocolos que deben ser rigurosamente analizados por comités de evaluación ética y científica y, por otra, hace falta un diálogo entre países, con el fin de evitar una presentación exitista de la técnica en el mercado sin mencionar sus dificultades inherentes. Una de las preocupaciones mayores es que la aceptación paulatina de este tipo de terapia, y la eliminación de restricciones, permita el uso de la técnica para terapia génica germinal y para terapia génica de mejoría, cuya validez ética es cuestionada. Usar la terapia génica en células germinales conlleva el riesgo de introducir daños genéticos en generaciones posterioresA terapia gênica constitui uma forma de manipulação genética que trata de corrigir ou diminuir os efeitos que ocasionam enfermidades de origem genética. Existem grandes esperanças no desenvolvimento deste tipo de terapia, sobretudo para doenças somáticas de origem genética que não tem cura. Existem, não obstante isso numerosos dificuldades técnicas que não estão totalmente resolvidas. Não se demostrou ainda a eficácia clínica e se pode causar danos irreversíveis no organismo. De um lado, existe a necessidade de regular por meio de protocolos que devem ser rigorosamente analisados por comitês de avaliação ética e científica, por outra, faz falta um diálogo entre países, para se evitar uma apresentação unilateral exitosa da t

  17. La Unidad de Terapia de Conducta de la Universidad de Barcelona

    OpenAIRE

    Saldaña García, Carmina; Bados López, Arturo; García-Grau, Eugeni; Balaguer, Gemma; Fusté-Escolano, Adela

    2009-01-01

    El trabajo presenta la Unidad de Terapia de Conducta (UTC) de la Universidad de Barcelona. La UTC nació en 1985 con la voluntad de formar a los psicólogos recién licenciados en la práctica profesional desde el modelo cognitivoconductual y crear un Servicio Clínico en la Facultad de Psicología que permitiera una mejora de la calidad de las actividades docentes e investigadoras a través de la asistencia psicológica a personas de dentro y fuera de la UB que así lo solicitaran. En el trabajo se d...

  18. Conocimientos y actitudes sobre terapias alternativas y complementarias en estudiantes de ciencias de la salud

    OpenAIRE

    Ballesteros-Peña, Sendoa; Fernández-Aedo, Irrintzi

    2015-01-01

    Introducción Las terapias alternativas y complementarias (TAC) han generado en el contexto sanitario actual tanto seguidores como detractores. Objetivo Explorar los conocimientos, percepciones y actitudes sobre las TAC en estudiantes universitarios de ciencias de la salud. Método Estudio descriptivo desarrollado en la Universidad del País Vasco (España) en el curso académico 2013-2014. Una muestra representativa de estudiantes cumplimentó un cuestionario anónimo con preguntas sobre conocimi...

  19. Desarrollo de tecnologías acústicas como terapia para la enfermedad de Parkinson

    OpenAIRE

    Gálvez García, Gerardo Miguel

    2015-01-01

    Las patologías neurológicas en la población -principalmente en la tercera edad- están experimentando un incremento en incidencia y prevalencia, básicamente por el aumento de la media de edad en las sociedades occidentales, así como debido a problemas medioambientales. Esta situación es oportuna para la aparición de nuevas terapias complementarias a las habituales de tratamientos farmacológicos, con efectos secundarios importantes o a la propia cirugía, muy invasiva. Si consideramos a la músic...

  20. Beneficios de la relajación en pacientes con patología cardiovascular y su relación con el patrón de conducta

    OpenAIRE

    Pérez Alonso, Verónica

    2017-01-01

    El objetivo de este estudio fue examinar los posibles efectos que producen las terapias de relajación con respecto a la frecuencia cardíaca, depresión, ansiedad y estrés, en pacientes con patología cardiovascular y su relación con el tipo de personalidad A. Este estudio cuenta con 16 pacientes (6 mujeres y 10 hombres) con edades comprendidas entre 40 y 82 años, todos participantes en el programa de rehabilitación cardíaca. La terapia de relajación se lleva a cabo una vez a la semana utiliz...

  1. La terapia manual osteopática

    OpenAIRE

    Escarmis i Costa, Francesc; Martínez Gil, José Luis

    2001-01-01

    Este trabajo desarrolla brevemente la historia de la Osteopatía, su introducción en Europa y cómo desde Europa ha ido viniendo a España de la mano de los Fisioterapeutas. Resume así mismo la Filosofía de la Osteopatía y sus principios. Y, por último, nos revela la situación actual de la Osteopatía en España y la necesidad que creemos que existe para su mayor desarrollo, estudio e integración dentro de la Fisioterapia. Terapia y Rehabilitación

  2. Fisioterapia asistida con perros en adolescentes con parálisis cerebral y dificultades en la motricidad fina. Un ensayo clinico

    OpenAIRE

    Ayarza Viadero, Adrián

    2016-01-01

    RESUMEN: Introducción: la parálisis cerebral (PC) se considera como un grupo de trastornos del desarrollo del movimiento y la postura, causantes de la limitación de la actividad. La espasticidad es una de las secuelas más frecuentes, cuya alteración interfiere en la rehabilitación y en las actividades de la vida diaria de estos niños. Una de las terapias alternativas con las que se trata es la terapia con perros. Su principio de aplicación se basa en que la interacción con los perros a la hor...

  3. Prospective randomized trial for the evaluation of the efficacy of low vs. high dose I-131 for post operative remnant ablation in differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Barrenechea, E.A.; Laureta, E.G.; Gaston, J.C.; Al-Nahhas, A.; Padhy, A.K.

    2005-01-01

    The study was done under the auspices of the IAEA to evaluate the efficacy of low dose (50-60mCi) vs. High dose (100 mCi) for the post-operative remnant ablation of differentiated thyroid cancer and to determine other factors associated with successful ablation. There were eighty-six patients included in the study with a diagnosis of papillary, follicular or mixed type of thyroid cancer. They all have undergone near total thyroidectomy or total thyroidectomy and without any evidence of metastatic disease. Four to six weeks after the surgery and without thyroid hormone maintenance as well as iodine free diet and drugs, they underwent a total body scan and uptake using 1-3 mci of I-131. Serum TSH and thyroglobulin were also taken. Randomization was made thru the IAEA and the patients either got a low dose or a high dose depending on such randomization. Of the 86 patients included, there were a total of 76 evaluable cases. There were three dropouts because of other medical conditions as upper GI bleeding, lung cancer and leg fracture. The 7 other patients have not completed their follow-up body scan. Among these patients were 67 females and 19 males whose age range was 19 to 84 years old. There were 65 cases with histologic type of papillary cancer, 15 follicular and 6 mixed varieties. Forty-one patients were randomized to the high dose group while 35 patients were assigned to the low dose therapy group. These patients were confined till their radiation activity was below 2mR/hr. Monitoring of the patients were done during their hospital stay. Post-therapy body scan was done but not with all patients. Most of the side effects noted were sialitis, mild neck pains, nausea and occasional vomiting as well as ageusia. These patients were maintained on thyroid hormone depending on their sensitivity but almost all were given 200-300mgs per day. The older patients tolerated only around 150mcgs/day. After four to six months, serum TSH, thyroglobulin and total body scan were

  4. Status of thyroidal radioiodine (I-131) uptake and urinary iodine in Bangladesh population: A re-look following implementation of universal iodination of salt

    International Nuclear Information System (INIS)

    Alam, F.; Sultana Haque, F.; Karim, M.A.; Faruque, O.; Ali, L.; Azad Khan, A.K.

    2007-01-01

    Iodide plays a central role in thyroid physiology and in the production of thyroid hormones, which are essential for normal vertebrate growth and development. Radioiodine uptake test is one of the oldest radionuclide investigations for evaluation of thyroid function. On the other hand useful information about the nutritional status of a population can be obtained by measuring the prevalence of deficiency in a population. The main aim of this study was to find out the present status of urinary iodine and thyroid uptake status of people living in and around Dhaka City (Bangladesh). The present study was carried out over a period of three years from 1999 to 2002 involving 300 subjects inclusive of 216 females and 84 males. Efforts were made to randomly include people from a broad spectrum of social and economic strata, starting from people belonging to the lowest to the highest income groups; as well as people representing the urban, rural and suburban populations. Urinary iodine levels and 24 hour percentage radioiodine uptake by the thyroid were estimated in all subjects included in this study. Subsequently patients were grouped into four categories based on the values of their percentage 24-hour radioiodine uptake; e.g., Group-A (N-99) with lowest uptake (0-5%), Group-B (N=100) with uptake ranging between 5-10%, Group-C (N=73) with uptake ranging between 10-30% and Group D (N=28) with uptake above 30%. The median 24 hours RAIU values in groups A, B, C and D were 3, 7, 23 and 34% respectively. The corresponding mean urinary iodine levels in the four groups were 43.31, 33.95, 12.97 and 9.35μgm/dl respectively. The results have shown that 1.04, 3.48, 16.72 and 78.74% people studied had levels of urinary iodine indicating severe, moderate, mild or no iodine deficiency respectively as per the WHO Criteria (Severe: <2 μgm /dl, Moderate: 2-4.9 μgm /dl, mild: 5.0-9.9μgm /dl, normal: ≥ 10 μgm /dl). It may be noted that the normal values of Thyroidal I-131 uptake were

  5. A new and simple test for the exocrinic function of the pancreas: Analysis of the urine after oral application of a I-131 labeled triglyceride

    International Nuclear Information System (INIS)

    Kropp, J.; Schmidt, S.; Wunderlich, G.; Schendtke, K.U.; Breidert, M.; McPherson, D.; Knapp, F.F. Jr.

    2002-01-01

    Aim: A simple non-invasive test for the exocrine function of the pancreas would be attractive to diagnose various diseases of this organ. 1,2-dipalmitoyl-3-[(15-p-[I-131]-iodophenyl)pentadecan-1-oyl]rac-glycerol (MIPPAG) has been evaluated for this purpose. Materials and Methods: After oral administration, IPPA is released from the triglyceride by the action of pancreatic lipases followed by intestinal absorption and subsequent metabolism. Radioiodinated phenylpropenoic acid as the final metabolite of IPPA is then conjugated and excreted into the urine. We investigated 7 normal volunteers, 13 patients without signs of pancreatic disease and 23 patients with pancreatic insufficiency (PI). About 1 MBq Iodine-131-MIPPAG were administered orally with subsequent urine collection for two 24 h periods. Blood samples were withdrawn after 1, 3, 6, and 24 hours. TLC analysis was performed on the serum lipid extracts. As a reference method for PI measurement of the elastase concentration in the feces was used. Results: Healthy subjects excreted 44.9% (SD: 7.5%) of the administered dose in the first 24 h and after 48 h this value cumulated to 61.9 % (SD: 8.1%) whereas patients with PI excreted 27.5% (SD: 15.4%) and 35.0% (SD: 18.7%), respectively. These values were statistically highly significant (p<0.00001) compared to normals. The TLC's showed two major peaks which corresponded to the standards iodine benzoic acid (IBA) and tripalmitin (TP). The IBA/TP ratio increased with time. The sensitivity and specificity of this new test was 78.3% and 100%, respectively. Sensitivity of the elastase test was only 54%. Conclusion: MIPPAG showed the expected physiologic behavior and a pancreatic insufficiency might be diagnosed by a simple urine analysis after oral application of this new tracer

  6. "Los colores que hay en mí": una experiencia de arte-terapia en pacientes oncológicos infantiles y cuidadores primarios

    OpenAIRE

    Rocío Angélica González Romo; Mónica Reyna Martínez; Cecilia del Carmen Cano Rodríguez

    2009-01-01

    Se implementó un taller de arte-terapia desde una perspectiva cognitiva para la identificación y expresión de emociones, así como la visualización a futuro para la reevaluación cognitiva de la enfermedad y la aceptación de sí mismo mediante técnicas gráfico-plásticas y narrativas. Se realizó asimismo un análisis acerca de los posibles ajustes a las actividades, de acuerdo con la identificación y agrupación teórico-práctica del arte-terapia en tres tipologías detectadas: arte-terapia ...

  7. Niños con necesidades educativas especiales y terapias asistidas con animales

    OpenAIRE

    García Novillo, Blanca

    2013-01-01

    Este es un Trabajo Final del Grado, centrado en los alumnos de “necesidades educativas especiales” y en lo importante de elegir una buena metodología para dar respuesta a sus necesidades integrando animales de compañía en su día a día, construyendo de esta forma una escuela inclusiva. En cada escuela y en cada clase hay un ciclo de evaluación, planificación, enseñanza y revisión de las necesidades de todos los niños. Esos estudios generales tienen en cuenta el amplio abanico de habilidades, a...

  8. Terapia psicológica para la esquizofrenia: Una realidad

    Directory of Open Access Journals (Sweden)

    Jennifer Del Toro Granados

    2013-10-01

    Full Text Available Resumen La esquizofrenia es entendida como un cuadro psiquiátrico, crónico y altamente discapacitante; en la cual, a pesar de las variaciones de la evolución en cada paciente, se observan los siguientes síntomas: ideas delirantes, alucinaciones, comportamiento desorganizado (síntomas positivos y aplanamiento afectivo (síntomas negativos. A finales de los años 70 se produce un cambio en la concepción etiológica de los trastornos psicóticos que comienzan a explicarse desde una perspectiva multicausal, es decir, como predeterminados e influidos por condiciones biopsicosociales. Uno de los más completos paquetes de intervención es la Terapia Psicológica Integral para la esquizofrenia (IPT. Los autores de este protocolo terapéutico parten del supuesto que los pacientes que reúnen criterios para esquizofrenia muestran déficits en varios niveles funcionales de organización de la conducta (nivel atencional-perceptivo, nivel cognitivo, nivel micro-social y nivel macro-social. En el presente análisis, se describen los hallazgos en términos de eficacia de la terapia psicológica integral para la esquizofrenia combinada con farmacoterapia; los distintos estudios reseñados indican que la IPT muestra superioridad terapéutica frente a otro tipo de intervenciones. (DUAZARY 2011, 93 - 98 AbstractSchizophrenia is defined as a table psychiatric, chronic and highly disabling, in the which, despite changes in the evolution of each patient, observe the following symptoms: ideas delusions, hallucinations, disorganized behavior (positive symptoms and blunted affect (symptoms negative. In the late 70’s is a change in the etiological concept of psychotic disorders starting to explain from a causes, ie as default and influenced by biopsychosocial conditions. One of the most complete packages of intervention is the therapy Comprehensive psychological schizophrenia (IPT. The authors of this therapeutic format asume Patients who meet criteria for

  9. El abandono de la adherencia en la terapia de reemplazo renal: una alarma en salud pública

    OpenAIRE

    Villegas-Alzate, Juan Diego; Vera-Henao, Sebastián; Jaramillo-Monsalve, María Camila; Jaramillo-Jaramillo, Laura Isabel; Martínez-Sánchez, Lina María; Martínez-Domínguez, Gloria Inés; Villegas-Gutiérrez, Iván

    2016-01-01

    La pérdida de la función renal amenaza la vida, su manejo es complicado y siempre ha sido un desafío para el personal de salud; debido a que el número de pacientes con Enfermedad Renal Crónica en diálisis va en aumento, es por esto que con porcentajes elevados de no adherencia el riesgo de mortalidad y hospitalizaciones comienza a convertirse en una preocupación importante en salud pública. Por esta razón se busca conocer el impacto sanitario de la no adherencia terapéutica a las terapias de ...

  10. La Terapia Dialéctico Conductual para el tratamiento del Trastorno Límite de la Personalidad.

    OpenAIRE

    Matilde Elices; Soledad Cordero

    2011-01-01

    La Terapia Dialéctico Conductual (TDC) ha sido creada por la Dra. Marsha Linehan, para el tratamiento de pacientes con intentos suicidas recurrentes y diagnóstico de Trastorno Limite de la Personalidad (TLP). Es un modelo terapéutico perteneciente a la “tercera ola” en psicoterapias cognitivas, puesto que se basa en las ciencias del comportamiento e incluye elementos de Mindfulness y de la filosofía dialéctica. En la actualidad la TDC es el tratamiento con mayor evidencia empírica para el TLP...

  11. Terapias regenerativas alternativas: versatilidad de uso, alcances y utilidad, en tendinopatías en la práctica clínica equina.

    Directory of Open Access Journals (Sweden)

    Christian Tuemmers

    2015-12-01

    Full Text Available A pesar de la alta actividad metabólica de los tenocitos y los esfuerzos terapéuticos vigentes, los tendones dañados se recuperan mediante la reparación en lugar de la regeneración, resultando en un tejido que no posee las mismas características del tendón original que permitan al equino retomar actividades competitivas. Frente a estos escenarios es que se han desarrollado numerosas terapias regenerativas, desde terapias autólogas que involucran la utilización de células mesenquimales y plasma rico en plaquetas, hasta diversas estrategias de ingeniería tisular y terapia génica. La recuperación organizada que mantiene la integridad del tejido original es extremadamente compleja, lo que se traduce en el inevitable proceso de reparación tisular con la utilización del tratamiento convencional, mientras que el uso de estas terapias regenerativas aumenta las posibilidades de lograr un tejido idéntico al original. No obstante, el uso de estas terapias no está exenta de limitantes relacionadas principalmente a las fallas terapéuticas y a la elección de la misma.

  12. Beneficios de la terapia cognitivo-conductual y la presoterapia en pacientes obesos: ensayo clínico aleatorizado Benefits of cognitive behavior therapy and acupressure therapy in obese patients: a randomized clinical trial

    OpenAIRE

    V. Torres; A. Mª Castro Sánchez; G. A. Matarán Peñarocha; I. Lara Palomo; Mª E. Aguilar Ferrándiz; C. Moreno Lorenzo

    2011-01-01

    Objetivo: el objetivo del presente trabajo fue analizar la modificación de los hábitos de vida en pacientes obesos mediante la terapia cognitivo-conductual administrada conjuntamente con la presoterapia. Métodos: Se realizó un estudio experimental con grupo control placebo. Se asignaron de forma aleatoria 40 pacientes a grupo de intervención (terapia cognitivo-conductual + presoterapia) y a grupo control (sesiones informativas). La dimensión de estudio fue la administración de un cuestionario...

  13. FUNÇÕES DESEMPENHADAS PELO ENFERMEIRO EM UNIDADE DE TERAPIA INTENSIVA

    Directory of Open Access Journals (Sweden)

    Micheli Grande Cenedési

    2012-01-01

    Full Text Available Estudio exploratorio, con enfoque cualitativo con objetivo general de identificar las funciones desarrolladas por enfermero en la Unidad de Terapia Intensiva, siguiendo el marco canadiense de función del enfermero (atención, educar, coordinar, supervisar y colaborar. Los datos fueron recolectados en 2009 mediante aplicación de cuestionario y observación sistemática de nueve enfermeros de una unidad de terapia intensiva de un hospital privado de Curitiba-PR, Brasil. Los datos obtenidos fueron clasificados por la técnica de análisis de contenido. Los resultados indican que los enfermeros son en su mayoría mujeres jóvenes, que no tienen experiencia en la unidad de cuidados intensivos. La observación de las actividades presenta que todas las funciones descritas en el marco son desarrolladas por los enfermeros del servicio, donde las funciones de coordinación, supervisión y atención técnica son las más significativas.

  14. Financial impact of outpatient clinic radioiodine therapy with sodium iodide I-131 for the treatment of patients with differentiated low-risk thyroid carcinoma in relation to hospital doses

    International Nuclear Information System (INIS)

    Berenguer, P.F.; Chang, T.M.C.; Silva, R.A.M.; Neto, A.H.D.; Belo, I.B.; Santos, M.A.P.

    2017-01-01

    Differential thyroid carcinoma (CDT) is the most prevalent endocrine malignancy in the world, with an excellent prognosis and a 10-year survival rate of over 95%. By 2013, the lowest activity of I-131 authorized by the Brazilian Unified Health System (SUS) in the therapy of patients with low-risk CDT was 3,700 MBq, requiring hospitalization. Recent studies have shown similar effectiveness between low and high doses of I-131 in the treatment of low-risk CDT. In 2014, the Ministry of Health included in the list of SUS procedures the use of lower activities (1,110 MBq and 1,850 MBq) for this purpose. The Brazilian National Nuclear Energy Commission (CNEN) also authorized the outpatient use of activity up to 1,850 MBq of I-131. Objective: To evaluate the financial impact of the adoption of ambulatory radioiodine therapy in patients with CDT of low-risk when compared to the hospital dose. Methods: Analysis of patients with CDT low-risk who were treated with an outpatient dose of I-131 from August / 2014 to January / 2017 at a nuclear medicine service in Recife, PE, Brazil. The cost of outpatient versus hospital doses was calculated. Results: A total of 289 patients underwent low doses of iodine therapy were evaluated, resulting in a savings of R$227,793.80. Conclusion: Outpatient radioiodine therapy in the treatment of patients with CDT of low-risk resulted in a 61.10% reduction in SUS expense, in addition to enabling faster care

  15. Interfaces y Sistemas en Rehabilitación y Compensación Funcional para la Autonomía Personal y la Terapia Clínica

    Directory of Open Access Journals (Sweden)

    Ramón Ceres

    2011-04-01

    Full Text Available Resumen: La Bioingeniería constituye un área de trabajo e investigación multidisciplinar entre las ingenierías y la medicina que resulta de un interés humano, social y económico creciente. La automática en particular, en sus aspectos de percepción, modelado, control, monitorización, actuación e interacción, entre otros, ofrece importantes conocimientos y herramientas para abordar los problemas relacionados con el diagnóstico y el seguimiento de patologías, con las necesidades funcionales especiales e igualmente con las diferentes terapias a aplicar. Este tutorial presenta aspectos relacionados con el estado del arte y últimos avances en los siguientes campos: Interfaces para la interacción y comunicación de personas con discapacidad, robótica para la rehabilitación y compensación funcional, y sistemas para la mejora de la terapia clínica. Palabras clave: Electroencefalografía, electromiografía, interfaz persona-máquina, rehabilitación, ventilación mecánica, tecnologías de apoyo, terapia clínica

  16. Terapia cognitivo-conductual y psicosis

    Directory of Open Access Journals (Sweden)

    CARLOS CUEVAS-YUST

    2002-01-01

    Full Text Available En una patología, la psicosis, tradicionalmente reservada al tratamiento psiquiátrico, resulta especialmente interesante y prometedora la aparición de las intervenciones psicológicas. De hecho, la terapia cognitivo-conductual (TCC está mostrando ser una aproximación efectiva en el tratamiento de síntomas psicóticos positivos resistentes a la medicación neuroléptica, existiendo incluso alguna evidencia de que podría contribuir a la reducción de las recaídas. En el presente trabajo describimos las etapas de la TCC en la psicosis, así como su adaptación a esta patología.

  17. Cómo evaluar e interpretar un artículo de terapia

    Directory of Open Access Journals (Sweden)

    D. Garlos Manterola, Dr.

    2011-01-01

    Quien escribe un manuscrito relacionado con terapia, o quien lee un artículo de este tipo espera al menos un objetivo claro, preciso y conciso respecto del escenario de la investigación que se realizó; la mención explícita del diseño empleado con los respectivos detalles metodológicos inherentes a este; y la mención y ejecución de herramientas estadísticas y medidas de asociación, o al menos los números necesarios para poder calcular estos valores, que finalmente permitan percibir consistencia y coherencia entre los objetivos, la metodología, los resultados y las conclusiones que fluyen del reporte.

  18. Financial impact of outpatient clinic radioiodine therapy with sodium iodide I-131 for the treatment of patients with differentiated low-risk thyroid carcinoma in relation to hospital doses; Impacto financeiro da radioiodoterapia ambulatorial com iodeto de sódio I-131 para tratamento de pacientes com carcinoma diferenciado da tireóide de baixo risco em relação às doses hospitalares

    Energy Technology Data Exchange (ETDEWEB)

    Berenguer, P.F.; Chang, T.M.C.; Silva, R.A.M.; Neto, A.H.D.; Belo, I.B., E-mail: pricilaberenguer@gmail.com [Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE (Brazil). Serviço de Medicina Nuclear; Santos, M.A.P. [Centro Regional de Ciências Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife (Brazil). Coordenação de Radioproteção

    2017-07-01

    Differential thyroid carcinoma (CDT) is the most prevalent endocrine malignancy in the world, with an excellent prognosis and a 10-year survival rate of over 95%. By 2013, the lowest activity of I-131 authorized by the Brazilian Unified Health System (SUS) in the therapy of patients with low-risk CDT was 3,700 MBq, requiring hospitalization. Recent studies have shown similar effectiveness between low and high doses of I-131 in the treatment of low-risk CDT. In 2014, the Ministry of Health included in the list of SUS procedures the use of lower activities (1,110 MBq and 1,850 MBq) for this purpose. The Brazilian National Nuclear Energy Commission (CNEN) also authorized the outpatient use of activity up to 1,850 MBq of I-131. Objective: To evaluate the financial impact of the adoption of ambulatory radioiodine therapy in patients with CDT of low-risk when compared to the hospital dose. Methods: Analysis of patients with CDT low-risk who were treated with an outpatient dose of I-131 from August / 2014 to January / 2017 at a nuclear medicine service in Recife, PE, Brazil. The cost of outpatient versus hospital doses was calculated. Results: A total of 289 patients underwent low doses of iodine therapy were evaluated, resulting in a savings of R$227,793.80. Conclusion: Outpatient radioiodine therapy in the treatment of patients with CDT of low-risk resulted in a 61.10% reduction in SUS expense, in addition to enabling faster care.

  19. Terapia de la risa en un grupo de mujeres adultas/ Laughter therapy in a group of elderly women

    Directory of Open Access Journals (Sweden)

    María M. Villam

    2013-05-01

    Full Text Available Objetivo: explorar los beneficios de la terapia de la risa en un grupo de mujeres adultas pertenecientes a un centro gerontológico del Municipio de Envigado (Colombia. Metodología: estudio con enfoque cualitativo mediante entrevista semiestructurada a 10 adultas entre 59 y 97 años de edad, antes y después de la aplicación de 5 sesiones, una semanal, de terapia de la risa por parte del grupo Mediclaun “payasos hospitalarios”. Resultados: muchos de los cambios percibidos en las adultas coinciden con la literatura en lo que respecta a una actitud más positiva, incremento de la confianza en el otro y la aceptación; expresan el pasado con menos dolor y un mayor agrado frente al acompañamiento familiar. Conclusiones: La terapia de la risa permite al adulto mayor encontrar fortalezas que puedan ayudarle a mejorar su presente, a su vez, lograr cambios en el individuo que se le revierten positivamente y a su relación con el entorno Objective: to explore the benefits of laughter therapy in a group of elderly women belonging to a gerontology center (Envigado, Colombia. Methodology: a qualitative study using a semi-structured interview with 10 adult women aged 59 to 97. The participants were interviewed before and after applying 5 weekly sessions of laughter therapy. Said therapy was administered by the Mediclaun "hospital clowns" group. Results: many of the changes observed in adult women are consistent with the results described in the literature in relation to a more positive attitude, increased confidence in people and acceptance; the participants expressed the past with less pain and had a greater liking towards family support. Conclusions: laughter therapy allows seniors to find the strength to improve their present situation, thus causing positive changes in their own self and in their relationship with their surroundings

  20. Organ S values and effective doses for family members exposed to adult patients following I-131 treatment: A Monte Carlo simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Han, Eun Young [Department of Radiation Oncology, University of Arkansas Medical Sciences, Little Rock, Arkansas 72205 (United States); Lee, Choonsik [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20852 (United States); Mcguire, Lynn; Brown, Tracy L. Y. [Department of Radiology, Division of Nuclear Medicine, University of Arkansas Medical Sciences, Little Rock, Arkansas 72205 (United States); Bolch, Wesley E. [J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States)

    2013-08-15

    Purpose: To calculate organ S values (mGy/Bq-s) and effective doses per time-integrated activity (mSv/Bq-s) for pediatric and adult family members exposed to an adult male or female patient treated with I-131 using a series of hybrid computational phantoms coupled with a Monte Carlo radiation transport technique.Methods: A series of pediatric and adult hybrid computational phantoms were employed in the study. Three different exposure scenarios were considered: (1) standing face-to-face exposures between an adult patient and pediatric or adult family phantoms at five different separation distances; (2) an adult female patient holding her newborn child, and (3) a 1-yr-old child standing on the lap of an adult female patient. For the adult patient model, two different thyroid-related diseases were considered: hyperthyroidism and differentiated thyroid cancer (DTC) with corresponding internal distributions of {sup 131}I. A general purpose Monte Carlo code, MCNPX v2.7, was used to perform the Monte Carlo radiation transport.Results: The S values show a strong dependency on age and organ location within the family phantoms at short distances. The S values and effective dose per time-integrated activity from the adult female patient phantom are relatively high at shorter distances and to younger family phantoms. At a distance of 1 m, effective doses per time-integrated activity are lower than those values based on the NRC (Nuclear Regulatory Commission) by a factor of 2 for both adult male and female patient phantoms. The S values to target organs from the hyperthyroid-patient source distribution strongly depend on the height of the exposed family phantom, so that their values rapidly decrease with decreasing height of the family phantom. Active marrow of the 10-yr-old phantom shows the highest S values among family phantoms for the DTC-patient source distribution. In the exposure scenario of mother and baby, S values and effective doses per time-integrated activity to

  1. Radiation dosimetry and first therapy results with a 124I/131I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy

    International Nuclear Information System (INIS)

    Zechmann, Christian M.; Afshar-Oromieh, Ali; Mier, Walter; Armor, Tom; Joyal, John; Stubbs, James B.; Hadaschik, Boris; Kopka, Klaus; Debus, Juergen; Babich, John W.; Haberkorn, Uwe

    2014-01-01

    Since the prostate-specific membrane antigen (PSMA) is frequently over-expressed in prostate cancer (PCa) several PSMA-targeting molecules are under development to detect and treat metastatic castration resistant prostate cancer (mCRPC). We investigated the tissue kinetics of a small molecule inhibitor of PSMA ((S)-2-(3-((S)-1-carboxy-5-(3-(4-[ 124 I]iodophenyl)ureido)pentyl)ureido) pentan edioicacid; MIP-1095) using PET/CT to estimate radiation dosimetry for the potential therapeutic use of 131 I-MIP-1095 in men with mCRPC. We also report preliminary safety and efficacy of the first 28 consecutive patients treated under a compassionate-use protocol with a single cycle of 131 I-MIP-1095. Sixteen patients with known prostate cancer underwent PET/CT imaging after i.v. administration of 124 I-MIP-1095 (mean activity: 67.4 MBq). Each patient was scanned using PET/CT up to five times at 1, 4, 24, 48 and 72 h post injection. Volumes of interest were defined for tumor lesions and normal organs at each time point followed by dose calculations using the OLINDA/EXM software. Twenty-eight men with mCRPC were treated with a single cycle of 131 I-MIP-1095 (mean activity: 4.8 GBq, range 2 to 7.2 GBq) and followed for safety and efficacy. Baseline and follow up examinations included a complete blood count, liver and kidney function tests, and measurement of serum PSA. I-124-MIP-1095 PET/CT images showed excellent tumor uptake and moderate uptake in liver, proximal intestine and within a few hours post-injection also in the kidneys. High uptake values were observed only in salivary and lacrimal glands. Dosimetry estimates for I-131-MIP-1095 revealed that the highest absorbed doses were delivered to the salivary glands (3.8 mSv/MBq), liver (1.7 mSv/MBq) and kidneys (1.4 mSv/MBq). The absorbed dose calculated for the red marrow was 0.37 mSv/MBq. PSA values decreased by >50 % in 60.7 % of the men treated. Of men with bone pain, 84.6 % showed complete or moderate reduction in pain

  2. Organ S values and effective doses for family members exposed to adult patients following I-131 treatment: A Monte Carlo simulation study

    International Nuclear Information System (INIS)

    Han, Eun Young; Lee, Choonsik; Mcguire, Lynn; Brown, Tracy L. Y.; Bolch, Wesley E.

    2013-01-01

    Purpose: To calculate organ S values (mGy/Bq-s) and effective doses per time-integrated activity (mSv/Bq-s) for pediatric and adult family members exposed to an adult male or female patient treated with I-131 using a series of hybrid computational phantoms coupled with a Monte Carlo radiation transport technique.Methods: A series of pediatric and adult hybrid computational phantoms were employed in the study. Three different exposure scenarios were considered: (1) standing face-to-face exposures between an adult patient and pediatric or adult family phantoms at five different separation distances; (2) an adult female patient holding her newborn child, and (3) a 1-yr-old child standing on the lap of an adult female patient. For the adult patient model, two different thyroid-related diseases were considered: hyperthyroidism and differentiated thyroid cancer (DTC) with corresponding internal distributions of 131 I. A general purpose Monte Carlo code, MCNPX v2.7, was used to perform the Monte Carlo radiation transport.Results: The S values show a strong dependency on age and organ location within the family phantoms at short distances. The S values and effective dose per time-integrated activity from the adult female patient phantom are relatively high at shorter distances and to younger family phantoms. At a distance of 1 m, effective doses per time-integrated activity are lower than those values based on the NRC (Nuclear Regulatory Commission) by a factor of 2 for both adult male and female patient phantoms. The S values to target organs from the hyperthyroid-patient source distribution strongly depend on the height of the exposed family phantom, so that their values rapidly decrease with decreasing height of the family phantom. Active marrow of the 10-yr-old phantom shows the highest S values among family phantoms for the DTC-patient source distribution. In the exposure scenario of mother and baby, S values and effective doses per time-integrated activity to the

  3. El legado psicoanalítico en la terapia cognitiva de Aaron Beck

    Directory of Open Access Journals (Sweden)

    Guido Pablo Korman

    2013-01-01

    Full Text Available El psicoanálisis en el que Beck se formó tenía como objetivo incluir al psicoanálisis dentro del modelo científico. Esto era consistente con los intereses de un gran número de investigadores clínicos en los Estados Unidos durante las décadas de 1950 y 1960. Este trayecto intelectual lo llevará, años después, a desarrollar la terapia cognitiva. En este trabajo nos enfocaremos en el entrenamiento psicoanalítico de Beck así como en las primeras publicaciones de éste como especialista en psiquiatría durante su práctica hospitalaria en la Clínica de Austen Riggs y en el Hospital Valley Forge Army. Analizaremos sus primeras hipótesis, intentando rastrear los indicios de su modo de actuar como psicoanalista. Esta misma formación posteriormente lo llevará a un replanteo del modelo psicoanalítico, hecho que será clave para explicar las características que adoptará la terapia cognitiva.

  4. Terapia VAC® en traumatismo grave de pierna izquierda VAC® therapy in severe left leg injury

    Directory of Open Access Journals (Sweden)

    F.J. De Juan Pérez

    2010-09-01

    Full Text Available Las fracturas abiertas de los miembros inferiores debidas a traumatismos de alta energía, suponen un reto terapéutico debido a la gravedad de las heridas, la afectación importante de varios tipos de tejidos y a la complejidad de los procedimientos quirúrgicos necesarios para su tratamiento que pueden llegar hasta complicadas técnicas microquirúrgicas mediante colgajos libres, quedarse en un colgajo muscular o compuesto, pediculado, o bien mantener una actitud más conservadora. Esto último es posible desde la aparición en los años 90 de una nueva técnica, la Terapia Vacuum Assisted Closure (Terapia VAC®, que se basa en la aplicación de vacío o presión negativa sobre la herida. Este recurso terapéutico permite una pauta más conservadora de tratamiento de estas fracturas tan complejas, reduciendo los riesgos, la morbilidad y minimizando las complicaciones. Presentamos un caso de fractura del miembro inferior izquierdo, abierta, compleja, con policontusión y aplastamiento, que creemos muy demostrativo del excelente resultado clínico que se puede obtener mediante el empleo de la terapia con presión negativa con el Sistema VAC®.The open fractures of the lower limb caused by high energy trauma, poses a major surgical challenge. These wounds have a significative complexity, with multiple lesions involving bone, muscle, nerves, vessels, skin and subcutaneous tissues. There are a wide spectrum of reconstructive options for the treatment, most of them requiring complex microsurgical transfers of autologous tissue. The Vacuum Assisted Therapy (VAC® has become a most useful tool for the plastic surgeon since the last century´s 90 decade. Based in the application of negative pressure to the wound bed, promotes healing by granulation tissue formation, keeping the wound clean and avoiding bacterial colonization. Used as a primary method or in combination with others, VAC® therapy allows more conservative options in the treatment of these

  5. Terapia VAC® en traumatismo grave de pierna izquierda VAC® therapy in severe left leg injury

    Directory of Open Access Journals (Sweden)

    F.J. De Juan Pérez

    2011-12-01

    Full Text Available Las fracturas abiertas de los miembros inferiores debidas a traumatismos de alta energía, suponen un reto terapéutico debido a la gravedad de las heridas, la afectación importante de varios tipos de tejidos y a la complejidad de los procedimientos quirúrgicos necesarios para su tratamiento que pueden llegar hasta complicadas técnicas microquirúrgicas mediante colgajos libres, quedarse en un colgajo muscular o compuesto, pediculado, o bien mantener una actitud más conservadora. Esto último es posible desde la aparición en los años 90 de una nueva técnica, la Terapia Vacuum Assisted Closure (Terapia VAC®, que se basa en la aplicación de vacío o presión negativa sobre la herida. Este recurso terapéutico permite una pauta más conservadora de tratamiento de estas fracturas tan complejas, reduciendo los riesgos, la morbilidad y minimizando las complicaciones. Presentamos un caso de fractura del miembro inferior izquierdo, abierta, compleja, con policontusión y aplastamiento, que creemos muy demostrativo del excelente resultado clínico que se puede obtener mediante el empleo de la terapia con presión negativa con el Sistema VAC®.The open fractures of the lower limb caused by high energy trauma, poses a major surgical challenge. These wounds have a significative complexity, with multiple lesions involving bone, muscle, nerves, vessels, skin and subcutaneous tissues. There are a wide spectrum of reconstructive options for the treatment, most of them requiring complex microsurgical transfers of autologous tissue. The Vacuum Assisted Therapy (VAC® has become a most useful tool for the plastic surgeon since the last century´s 90 decade. Based in the application of negative pressure to the wound bed, promotes healing by granulation tissue formation, keeping the wound clean and avoiding bacterial colonization. Used as a primary method or in combination with others, VAC® therapy allows more conservative options in the treatment of these

  6. Estado actual de las terapias con células madre derivadas de tejido adiposo en el ámbito de la Cirugía Plástica The state of the adipose-derived stem cell therapies in Plastic Surgery

    Directory of Open Access Journals (Sweden)

    J.M. Lasso

    2010-09-01

    Full Text Available Durante la última década, la terapia celular ha emergido como una estrategia útil en el tratamiento de diversas enfermedades como la isquemia miocárdica y las fístulas en la enfermedad de Crohn; pero últimamente, hay también ya líneas de investigación centradas en su uso en reconstrucción mamaria, cuyos resultados van siendo publicados paulatinamente. Existen varios tipos de células madre adultas que han sido investigadas en estudios preclínicos y clínicos diseñados para este propósito: células de medula ósea, células del sistema circulatorio y mioblastos y, recientemente se está trabajando en una población de células madre en el tejido adiposo, que presentan una fácil extracción y manipulación. Estas células son capaces de diferenciarse en múltiples líneas celulares, como los adipocitos y las células endoteliales entre otras. En el presente artículo, trataremos de hacer una revisión de los principios básicos de las células madre derivadas del tejido adiposo (tipos, características, procesos de obtención y multiplicación, los primeros estudios experimentales y los ensayos clínicos que están siendo realizados en la actualidad.Over the past decade, cell therapy has emerged as a new approach to reverse several diseases as myocardial ischemia and fistula in Crohn disease; but lately new efforts are centered in breast reconstruction. Several types of adult stem cell have been studied in both preclinical and clinical condition for this purpose: bone marrow cells, circulating cells, and myoblasts. Recently the existence of a population of stem cells located in the adipose tissue has been observed. These cells are able to differentiate into multiple cell lineage including adipocytes and endothelial cells. In this review we discuss the basic principle of adipose-derived stem cell (types, characteristic, harvesting and expansion, the initial experimental studies and the currently ongoing clinical trials.

  7. Efectos morfológicos de la terapia génica restauradora de la timulina sobre la adenohipófisis de ratones atímicos

    OpenAIRE

    Martines, Eliana

    2012-01-01

    El objetivo general de la presente tesis es implementar una terapia génica pituitaria neonatal mediante el vector adenoviral portador del gen sintético para timulina (RAd- FTS), con el fin de prevenir deficiencias en las poblaciones adenohipofisarias, en los niveles séricos de la timulina y de las hormonas hipofisarias de ratones nude Facultad de Ciencias Médicas

  8. Lipoproteína a, aterosclerosis y terapia hormonal de reemplazo Lipoprotein a, atherosclerosis and replacement hormone therapy

    Directory of Open Access Journals (Sweden)

    Miguel Lugones Botell

    2005-08-01

    Full Text Available Se realizó una revisión sobre la lipoproteína plasmática, Lp(a, cuyo papel fisiológico es poco conocido. Se ha descrito una asociación entre las concentraciones aumentadas de Lp(a y el proceso aterosclerótico. Además, su exceso podría inducir una disminución de la actividad fibrinolítica y, por tanto, favorecer la trombosis. También analizamos la terapia hormonal de reemplazo. En relación con los efectos positivos, mejora los síntomas climatéricos y previene la osteoporosis, aunque entre los efectos adversos en las mujeres que la siguen, se ha descrito un ligero aumento del riesgo del tromboembolismo venoso, y más recientemente, en estudios realizados en EE.UU. en los años 2002 y 2004, en el ya conocido estudio (Women´s Health Initiative Study, se reportó mayor incidencia de eventos cardiovasculares para la terapia combinada con estrógenos conjugados equinos y medroxiprogesterona, y de stroke para la terapia estrogénica. Estos estudios pusieron en su lugar los efectos de esta terapia, que no es totalmente inocua. Se precisan estudios más amplios para definir el papel de la terapia hormonal de reemplazo y otras medidas terapéuticas sobre el sistema hemostático, el metabolismo lipídico y la enfermedad cardiovascular.A review of plasmatic lipoprotein, Lp(a, whose physiological role is little known, was made. An association between the augmented concentrations of Lp(a and the atherosclerotic proccess has been described. Besides, its excess may lead to a reduction of the fibrinolytic activity and, therefore, favor thrombosis. The replacement hormone therapy was also analyzed. In relation to its positive effects, it improves the climacteric symptoms and prevents osteoporosis. Among its adverse effects, it has been observed a mild increase of the risk for venous thromboembolism and, more recently, in the aleady known Women's Health Initiative Study, it was reported a higher incidence of cardiovascular events for the combined

  9. La Terapia Dialéctico Conductual para el tratamiento del Trastorno Límite de la Personalidad.

    Directory of Open Access Journals (Sweden)

    Matilde Elices

    2011-06-01

    Full Text Available La Terapia Dialéctico Conductual (TDC ha sido creada por la Dra. Marsha Linehan, para el tratamiento de pacientes con intentos suicidas recurrentes y diagnóstico de Trastorno Limite de la Personalidad (TLP. Es un modelo terapéutico perteneciente a la “tercera ola” en psicoterapias cognitivas, puesto que se basa en las ciencias del comportamiento e incluye elementos de Mindfulness y de la filosofía dialéctica. En la actualidad la TDC es el tratamiento con mayor evidencia empírica para el TLP, demostrando ser efectiva en la reducción de varios problemas asociados a este trastorno, como ser: autolesiones, intentos de autoeliminación, ideación suicida, desesperanza, depresión y comportamientos asociados a la bulimia. El objetivo de este artículo es desarrollar los fundamentos teóricos y conceptuales básicos sobre los que se construye la TDC, y exponer sus principales directrices de tratamiento. También se establecen las principales diferencias con la terapia cognitivo – conductual standard.

  10. El Uso terapéutico del self como herramienta en Terapia Ocupacional

    OpenAIRE

    Pérez Corrales, Jorge

    2014-01-01

    V Jornadas de actualización en terapia ocupacional: Formación continuada en terapia ocupacional, celebradas en la Universidad Rey Juan Carlos campus de Alcorcón en 2014. Fisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física

  11. Terapias creativas en la unidad de hospitalización breve psiquiátrica

    OpenAIRE

    Asensio, Carmen

    2014-01-01

    V Jornadas de actualización en terapia ocupacional: Formación continuada en terapia ocupacional, celebradas en la Universidad Rey Juan Carlos campus de Alcorcón en 2014. Fisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física

  12. Terapia acuática en alteraciones de equilibrio de origen neurológico

    OpenAIRE

    Álvaro Macarrilla, Nagore

    2014-01-01

    RESUMEN: Objetivo: El objetivo de este trabajo, es realizar una revisión de la literatura actual sobre la efectividad de la Terapia Acuática (TA) en el tratamiento rehabilitador de las patologías neurológicas que cursan con una alteración del equilibrio estático y/o dinámico. Material y métodos: Para la elaboración de esta revisión se ha efectuado una búsqueda exhaustiva de las principales bases de datos de ciencias de la salud (PubMed, PEDro, ScienceDirect, Cochrane y LILACS). El principal p...

  13. Uso de la terapia familiar en la psiquiatría infantil

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    Rafael Vasquez

    1986-07-01

    Full Text Available EI artículo muestra la experiencia del autor, en el empleo de la técnica de la terapia familiar sistémica, como auxiliar terapéutico en el manejo de las consultas más frecuentes, atendidas en los servicios psiquiátricos oficiales. Tales quejas, en orden de frecuencia son: bajo rendimiento escolar, inquietud, enuresis, encopresis y trastornos psicofisiológicos. EI trabajo contiene la experiencia con las cuatro primeras, por cuanto el manejo de los trastornos psicofisiológicos, demanda una técnica particular que no es objeto de esta comunicación. No se reporta una cuantificación de resultados, pero se describen como buenos. EI enfoque del manejo global del caso está dentro de los postulados generales de la teoría general de los sistemas y los desarrollos posteriores del método biopsicosocial.

  14. Terapia génica como herramienta molecular para regenerar células ciliadas

    OpenAIRE

    Maass O,Juan Cristóbal; Carrasco M,Loreto; Dentone S,Luis; Kukuljan P,Manuel

    2009-01-01

    La hipoacusia es un gran problema de salud pública. Un daño frecuente encontrado es la pérdida irreversible de las células ciliadas de la cóclea, con preservación de células de sostén, fenómeno común en mamíferos. Las terapias existentes no están orientadas a solucionar el problema de fondo. Trabajos muestran que se puede obtener regeneración ¡n vivo de células ciliadas y mejoría de los umbrales auditivos, mediante la sobrexpresión de Atohl en células de sostén del órgano de Corti (gen fundam...

  15. Terapia a la pregunta filosófica: ¿qué es el arte?

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    Adryan Fabrizio Pineda Repizzo

    2011-12-01

    Full Text Available En la tradición del pensamiento occidental, la pregunta “¿Qué es el arte?” ha jugado un papel central, aunque enigmático, para el campo de la filosofía, donde se han avanzado tantas objeciones y respuestas tentativas, que hoy pareciera que han sido tantos esfuerzos sin rumbo ni asidero en el mundo real del arte. Este texto afronta la plausibilidad de asumir la pregunta “¿Qué es el arte?” como problema filosófico. Para responder a este cuestionamiento acudimos a Wittgenstein, con el fin de realizarle una terapia filosófica a la pregunta misma y así mostrar que los principales paradigmas filosóficos sobre este asunto no son sino la manifestación de una confusión del lenguaje en torno al término ‘arte’.  

  16. Pulpotomía con electrocauterio en pacientes con hemofilia A

    OpenAIRE

    Carbonell Rodriguez, Rosario

    2017-01-01

    Rehabilita la salud oral de un niños con Hemofilia A, empleando el Electrocauterio como una alternativa en la terapia pulpar, específicamente en la pulpotomía, para lo cual se realiza un minucioso examen clínico y anamnesis, que respaldados con exámenes complementarios, permite determinar el plan de tratamiento. La rehabilitación integral se llevó a cabo, previo consentimiento informado del padre, en sala de operaciones bajo anestesia general, debido a la condición sistémica del niño. Incl...

  17. Terapia oclusiva em ambliopia: fatores prognósticos

    OpenAIRE

    Salata,Ana Carolina Fava; Villaça,Veridiana Toledo Nascimento; Roma,Renato Lopes; Norato,Denise Yvonne Janovitz; Carvalho,Keila Miriam Monteiro de

    2001-01-01

    Objetivos: Ambliopia é o defeito visual mais comum em crianças e por mais de 250 anos a terapia oclusiva vem sendo o melhor tratamento. Sendo assim, propusemo-nos a determinar os fatores que influenciam no sucesso do tratamento da ambliopia por terapia oclusiva em nosso meio. Métodos: Foi realizado um estudo retrospectivo com 169 crianças amblíopes atendidas no Ambulatório de Ambliopia do Hospital de Clínicas da UNICAMP, Campinas (SP), entre janeiro de 1996 e maio de 1998. A população atendid...

  18. Los ensueños en terapia gestáltica

    Directory of Open Access Journals (Sweden)

    Francisco Vásquez

    2003-06-01

    Full Text Available Se describe el ensueño a través de los tiempos y el significado que tiene y tuvo según las épocas y las culturas. Se enfoca la teoría general de los ensueños desde Hipócrates hasta nuestros días, así como su interpretación, tanto del punto de vista psicológico como religioso y cultural. Se hace énfasis en la función terapéutica de los ensueños, tanto en la terapia freudiana como la jungiana y la gestáltica. Reflexiona sobre los aportes de Freud, Jung y Perls, ampliando los conceptos del ensueño de la terapia gestáltica, que considera el ensueño "como el camino real a la integración, siendo la producción humana más espontánea de la existencia. El ensueño es la expresión que nos llega sin intención, voluntad y deseo. El ensueño más absurdo no nos impacta en el mismo momento como algo absurdo, se siente como verdadero. El ensueño es mucho más que un deseo inconcluso, es un mensaje existencial muy claro acerca de lo que falta en nuestras vidas, lo que se evita hacer y vivir". Se ilustra el ensayo con un trabajo de ensueño con una paciente en la Clínica de Día, del Hospital Guillermo Almenara, empleando las técnicas gestálticas. El ensayo se circunscribe a una apreciación de la filosofía y praxis gestáltica sobre los ensueños.

  19. La terapia hormonal de reemplazo en la pre y pos menopausia: tendencias y controversias

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    Sánchez-Ramírez, Georgina

    2008-07-01

    Full Text Available Con la finalidad de contribuir a una actualización del estado del arte y bajo una perspectiva crítica, se realizó una revisión bibliográfica sobre las indicaciones terapéuticas de la Terapia de Reemplazo Hormonal, así como las diferentes controversias, usos y beneficios durante la pre y la posmenopausia. Los beneficios demostrados hasta el momento de la THR, son la corrección de la atrofia urogenital y/o vaginal y la disminución de las molestias de los síntomas vasomotores (los sofocos o bochornos, los vértigos, las sensaciones de hormigueo en las extremidades y palpitaciones y el aumento de la DMO que puede prevenir las fracturas de cadera y vértebras. Las dosis recomendadas para la administración de THR han variado con el tiempo, cobrando fuerza últimamente la corriente clínica que recomienda dosis menores que las utilizadas en años anteriores, ya que se están demostrando los mismos beneficios, disminuyendo los riesgos asociados a su uso, lo cual requiere una actualización en la información que manejan tanto los médicos como las usuarias. Existe además la necesidad de ampliar las investigaciones sobre el uso de otro tipo de terapias para aliviar la sintomatología climatérica diferente a la THR.

  20. Tratamiento de la diabetes mellitus tipo 2 en el municipio de Güines, año 2002: Análisis con énfasis en la terapia medicamentosa Treatment of type 2 diabetes mellitus in Güines municipality in the year 2002: Drug therapy-based analysis

    Directory of Open Access Journals (Sweden)

    José Luis Valenciaga Rodríguez

    2003-08-01

    Full Text Available Se realizó una investigación de corte transversal con el objetivo de identificar las características del tratamiento en personas con diabetes mellitus tipo 2 pertenecientes al municipio de Güines, en el año 2002, específicamente en la utilización de compuestos orales normo o hipoglucemiantes e insulina. El universo lo constituyeron 3 017 diabéticos tipo 2 registrados en el municipio en el año 2001, y la muestra 328 de estos casos, seleccionados a través de diseño muestral complejo (estratificado en la primera etapa y por conglomerados en la segunda. Los datos obtenidos se procesaron estadísticamente, con el empleo del programa SPSS (versión 10. La media de edad de la muestra fue de 65, 2 años y de 12,8 de la fecha de diagnóstico. Un total de 161 personas (49,1 % se trataba con dieta solamente y 42 con insulina; de ellos todos empleaban insulina de acción intermedia y 3 (7,1 % la de acción rápida. El compuesto hipoglucemiante más utilizado fue la Glibenclamida, en 131 casos (85,5 %, y su dosis media diaria fue de 15 mg, mientras aproximadamente 1 de cada 10 casos empleaba medicina verde. Se concluye que existen deficiencias en el manejo terapéutico, específicamente en la forma de utilización de insulina, escasa disponibilidad de compuestos orales normo o hipoglucemiantes y alta frecuencia de tratamiento no farmacológico. Se recomienda reanalizar el cumplimiento del Programa Nacional de Diabetes Mellitus en el municipio de Güines, con énfasis en la capacitación del personal de salud en aspectos terapéuticos, así como incrementar la disponibilidad de compuestos orales normo o hipoglucemiantes, específicamente de Metformin, en el municipio.A cross-sectional study was made to identify the characteristics of treatment of persons with type 2 diabetes mellitus in Güines municipality during 2002, particularly the use of oral normo or hypoglicemic compounds and insulin. The universe was made up of 3 017 type 2 diabetics

  1. Beneficios de las terapias ecuestres. Estudio de caso: Asociación Hispalense de Terapias Ecuestres y la Herradura

    OpenAIRE

    González Prior, Marta

    2016-01-01

    En el ámbito de la diversidad funcional, son muchas las terapias que podemos encontrar como método de rehabilitación y de mejora de las áreas afectadas de este colectivo. La naturaleza y los animales, en nuestro caso los caballos, son los factores que diferencian las terapias ecuestres del resto, aportando multitud de beneficios, no sólo en el área física, sino también en áreas psicológicas y sociales. Numerosas investigaciones centran su objetivo en estudiar los beneficios en las personas qu...

  2. Terapia antiviral para VIH-SIDA

    Directory of Open Access Journals (Sweden)

    Alicia Tarinas Reyes

    2000-12-01

    Full Text Available En los últimos años, muchos agentes antivirales nuevos han sido incorporados a la quimioterapéutica. En esta revisión se resumen tanto los fármacos establecidos de años atrás como los nuevos medicamentos desarrollados para el tratamiento de individuos infectados por VIH. El AZT fue el primero aprobado en marzo de 1987, le siguió el ddl (1991, ddC (1992, d4T (1994, 3TC (1995. Luego fue aprobado el primer inhibidor de proteasa, saquinavir en diciembre de 1995, seguido de ritonavir (1996, indinavir (1996, nelfinavir (1997; además de otros inhibidores de la reverso transcriptasa como nevirapine (1996, delavirdine (1997, efavirenz (1998, entre otros. En estos momentos se siguen buscando y desarrollando nuevas terapias alternativas para esta afección. En este trabajo se exponen algunas de las características de dichos medicamentos, como son: mecanismos de acción (sobre qué enzima actúa cada uno y cómo lo hacen, el ciclo viral, dosificación, incompatibilidades y reacciones adversas.During the last years many new antiviral agents have been incorporated to the chemotherapeutics. The pharmaceuticals established years ago as well as the new ones developed to treat HIV infected individuals are included in this review. The AZT was the first approved in March, 1987, followed by ddl (1991, ddc (1992, d4t (1994, and 3TC (1995. Later, the first protease inhibitor, saquinovir, was approved in December, 1995, followed by ritonavir (1996, indinavir (1996, and nelfinavir (1997; in addition to other inhibitors of the reverse transcriptase as neviparine (1996, delavirdine (1997, and efavirenz (1998, among others. At present new alternative therapies for this affection are being searched and developed. Some of the characteristics of these dugs, such as: action mechanisms (on which enzime each of them act and how they do it, viral cycle, dosage, incompatibilites and adverse reactions are dealt with in this paper.

  3. Percepções de profissionais de enfermagem sobre intervenções de Terapia Ocupacional em Saúde Mental em hospital universitário Percepciones de profesionales de enfermería sobre intervenciones de Terapia Ocupacional en Salud Mental en hospital universitario Perceptions of professional nurses about occupational therapy interventions in mental health at a university hospital

    Directory of Open Access Journals (Sweden)

    Solange Tedesco

    2011-01-01

    Full Text Available OBJETIVO: Conhecer as percepções de profissionais de enfermagem sobre intervenções grupais de Terapia Ocupacional em Saúde Mental realizadas com pacientes internados em um hospital universitário. MÉTODOS: Estudo de abordagem qualitativa do tipo descrito. As anotações das coordenadoras dos grupos de Terapia Ocupacional foram analisadas em relação às entrevistas abertas junto a n enfermeiras e n técnicos de enfermagem que participaram das intervenções grupais de Terapia Ocupacional pelo período de dois anos. As respostas foram submetidas à análise do Discurso do Sujeito Coletivo (DSC. RESULTADOS: Foram identificadas quatro ideias centrais do DSC: a Terapia Ocupacional como favorecedora do cuidado integrado, valorizando o sujeito e sua experiência; a terapia ocupacional como processo de ajuda e cuidado para a própria equipe; o grupo de Terapia Ocupacional como espaço de ressonância e facilitação no manejo com o paciente em razão da percepção de aspectos relacionais. CONCLUSÃO: As estratégias foram percebidas, quer como promotoras da reorganização da situação vivida pelo paciente na internação, quer como oportunidades de ensino e apoio para a equipe de enfermagem.OBJETIVO: Conocer las percepciones de profesionales de enfermería sobre intervenciones grupales de Terapia Ocupacional en Salud Mental realizadas con pacientes internados en un hospital universitario. MÉTODOS: Estudio de abordaje cualitativo del tipo descrito. Las anotaciones de las coordinadoras de los grupos de Terapia Ocupacional fueron analizadas en relación a las entrevistas abiertas junto a n enfermeras y n técnicos de enfermería que participaron de las intervenciones grupales de Terapia Ocupacional por el período de dos años. Las respuestas fueron sometidas al análisis de Discurso del Sujeto Colectivo (DSC. RESULTADOS: Se identificaron cuatro ideas centrales del DSC: la Terapia Ocupacional como favorecedora del cuidado integrado, valorizando

  4. DANO OCUPACIONAL NA UNIDADE DE TERAPIA INTENSIVA NEONATAL: A PERCEPÇÃO DA ENFERMEIRA

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    MARIA ALVANI DIAS PEDROZA

    2006-01-01

    Full Text Available Se trata de estudio cuantitativo, exploratorio y descriptivo, con el objetivo de conocer la percepción de las enfermeras con respecto a la influencia del desempeño en la asistencia de enfermería y en el ambiente laboral. Tuvo por escenario la Unidad de Terapia Intensiva Neonatal (UTIN de una maternidad escuela, en Fortaleza-CE. Recogimos los datos entre agosto y septiembre de 2004 a través de un cuestionario estructurado en parte, aplicado a 24 enfermeras activas. Verificamos que la mayor concentración de enfermeras (un 37,5% pertenece al grupo de las que ya tienen entre uno a cinco años de trabajo y que 19 (un 79% de ellas poseen otro trabajo, sometidas a una altísima carga horaria. El exceso de trabajo, el estrés y el ruido son los factores que más incomodan en el local, desencadenando el exceso de actividades y cansancio físico. Concluimos que el estrés existente en esta unidad es lo que causa mayor daño a la práctica laboral. El hecho de que esto ocurra con mucha frecuencia nos plantea una reflexión sobre las consecuencias que aporta a la salud del profesional /cuidador, mostrándonos la necesidad de mejorar las condiciones de trabajo.

  5. Stress in nurses working in intensive care units El estrés de los enfermeros que actúan en una unidad de terapia intensiva Estresse de enfermeiros com atuação em unidade de terapia intensiva

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    Ana Maria Cavalheiro

    2008-02-01

    Full Text Available The present study aimed to identify the presence of stress in nurses working in intensive care units, the stressing agents and symptoms associated to the nurses' perceptions of stress, and to assess the correlation between the occurrence of stress, sources of stress, and symptoms shown by the nurses. Seventy-five nurses took part in the study. The data were collected from questionnaires, analyzed with the Pearson correlation coefficients, and adjusted by general linear models. The study showed the presence of stress related to work dissatisfaction, activities regarded as critical situations in intensive care units, symptoms related to cardiovascular, digestive and musculoskeletal disorders. The conclusion is that stress is present in nurses' activities in intensive care units, related to characteristics of the health area itself, causing dissatisfaction and stress-related symptoms.El presente estudio tuvo como objetivos: identificar la presencia de estrés en enfermeros que trabajan en unidades de terapia intensiva; identificar a los agentes estresantes y a los síntomas asociados al estrés, según la percepción del enfermero; y, evaluar la correlación entre la presencia del estrés, las fuentes del estrés y los síntomas presentados por los enfermeros. Setenta y cinco enfermeros participaron del estudio. Los datos fueron recolectados por medio de cuestionarios. El análisis fue realizado utilizando los coeficientes de correlación de Pearson y ajustando con modelos lineales generalizados. El estudio mostró la presencia de estrés correlacionado a: la insatisfacción en el trabajo; a las actividades consideradas como situaciones críticas en unidad de terapia intensiva; a los síntomas relacionados con alteraciones cardiovasculares; al aparato digestivo y a los músculos del esqueleto. La conclusión del estudio es que el estrés está presente en la actividad del enfermero en las unidades de terapia intensiva y está correlacionado a

  6. Comparison of chromatography and Sep-pak methods for estimating the radiochemical purity of I-123 and I-131 labelled meta-iodobenzylguanidine (mIBG), synthesised in house

    International Nuclear Information System (INIS)

    Kumar, V.

    1998-01-01

    Full text: Radioiodine (I-123 or I-131) labelled mlBG has been prepared routinely in-house in a number of radiopharmacy laboratories. The radiochemical purity can be estimated by several methods. Available literature suggests that the results of chronatographic analysis are comparable with electrophoresis and high pressure liquid chromatography (HPLC) methods which are considered as gold-standard procedures. However, due to the cost involved with these equipments most of the radiopharmacy laboratories are not fortunate enough to have them. The present study compares the validity of reverse-phase Sep-pak cartridge method against chromatographic technique. We analysed twenty four preparations of mIBG by both Sep-pak and chromatography methods (20 batches of I-123 mD3G and 4 batches of I-131 mIBG). Chromatographic analysis, which takes >2hrs, was performed with Whatman No 1/ n-butanol: acetic acid: water (60:15:25 v/v) and the activity associated with the peaks for free iodine and I-123 mD3G were measured. Sep-pak cartridge method, which takes less than 10 min, was performed as follows: the cartridge was activated by injecting 5 mL ethanol (200% pure) followed by flushing with 5mL distilled water. A sample (0.1mL) of radioiodine labelled mD3G was applied to the column and was eluted with 5mL distilled water. Subsequently two aliquots of 5mL solution containing tetrahydrofuran: (0.1M) sodium dihydrogen phosphate (25:75v/v) were passed through and the activity in each elute was measured. Analysing the results by Student's paired t-test for I-123 mlBG using the Sep-pak method gave a mean + SD of 98.8+ 0.6 % which correlated well (r 2 = 0.780) with the results obtained by the chromatographic method 99.3+0.5% (p <0.05). The results obtained for free I-123 by the two methods were 1.09 + 0.56% and 0.6 + 0.5% (p <0.05) respectively. The parameters did not differ significantly when I-131, instead of I-123, was used to synthesise mIBG. The results clearly indicate that the Sep

  7. Modificación de la personalidad mediante una terapia cognitivo-conductual de afrontamiento al estrés

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    Julia Linares-Ortiz

    2014-01-01

    Full Text Available El objetivo de este estudio ha sido comprobar la posibilidad de modulación de variables de personalidad (tales como algunos de los Cinco Grandes Factores, o la personalidad resistente a través de la aplicación de un programa de afrontamiento del estrés. Para ello, han participado 26 personas del ámbito universitario con alto estrés percibido, distribuidas en dos grupos (grupo de tratamiento y grupo de control. Los instrumentos de evaluación seleccionados se clasificaron en dos grupos: variables psicológicas y emocionales y variables de personalidad. Los resultados encontrados mediantes un ANOVA de medidas repetidas mostraron que existía interacción momento x grupo en las variables optimismo, extraversión y responsabilidad, correspondientes al Modelo de los Cinco Grandes Factores, mostrando un incremento de las puntuaciones en estas variables en el grupo terapia y no encontrándose dicha interacción en el grupo control. Las puntuaciones en los componentes de neuroticismo, amabilidad, apertura a la experiencia y personalidad resistente no se modificaron en ninguno de los dos grupos. Este estudio apoya la idea de que modificando determinados parámetros emocionales relacionados con el estrés mediante terapia cognitivo-conductual se pueden ver modulados algunos factores de personalidad.

  8. Evolução clínica de pacientes com insuficiência renal aguda em unidade de terapia intensiva Evolución clínica de pacientes con insuficiencia renal aguda en la unidad de cuidados intensivos The clinical outcome of patients with acute renal failure in intensive care unit

    Directory of Open Access Journals (Sweden)

    Lucienne Dalla Bernardina

    2008-01-01

    Full Text Available OBJETIVO: Avaliar a evolução clínica de pacientes com insuficiência renal aguda (IRA submetidos a tratamento dialítico e não-dialítico na UTI. MÉTODOS: Estudo prospectivo onde foram incluídos pacientes com idade maior que 18 anos e com creatinina sérica > 1,5 mg/dl. Os pacientes foram divididos em grupo dialítico e não-dialítico. RESULTADOS: Dos 70 pacientes incluídos 19 (27,1% foram do grupo dialítico e 51 (72,9% do grupo não-dialítico. A taxa de mortalidade foi de 42,1% no grupo dialítico e de 33,3% no grupo não-dialítico (pOBJETIVO: Evaluar la evolución clínica de pacientes con insuficiencia renal aguda (IRA sometidos a tratamiento dialítico y no-dialítico en la UCI. MÉTODOS: Se trata de un estudio prospectivo donde fueron incluídos pacientes mayores de 18 años y con creatinina sérica > 1,5 mg/dl. Los pacientes fueron divididos en grupo dialítico y no-dialítico. RESULTADOS: De los 70 pacientes incluídos 19 (27,1% fueron del grupo dialítico y 51 (72,9% del grupo no-dialítico. La tasa de mortalidad fue del 42,1% en el grupo dialítico y del 33,3% en el grupo no-dialítico (pOBJECTIVE:To evaluate the clinical outcome of acute renal failure (ARF patients when submitted to dialysis and non-dialysis treatments in ICU. METHODS: this prospective study included patients over 18 years of age and serum creatinine of >1.5 mg/dl. The patients were included in dialysis and non-dialysis groups. RESULTS: The study included 70 patients, 19 (27.1% comprised the dialysis group and 51 (72.9% the non-dialysis group. In the dialysis group, mortality rate was 42.1% and in the non-dialysis group was 33.3% (p<0.58. CONCLUSION: There were multifactors of ARF in ICU, but ARF is not the single cause for the high mortality rate in ICU patients.

  9. Evolución de la terapia ocupacional en el campo de la oncología = Occupational therapy evolution in oncology field

    OpenAIRE

    Navarrete Salas, E

    2006-01-01

    Resumen:El objetivo de lasiguiente revisión bibliográfica fue conocer la trayectoria de la Terapia Ocupacional (T.O.) en el área oncológica durante las últimas 4 décadas. Para ello se realizó una búsqueda en las bases de datos MEDLINE, EMBASE, CINALH y AMED, con los descriptores Terapia Ocupacional, oncología y cáncer, tanto en el título como en el abstract; se excluyeron los artículos que no estuviesen en idioma inglés o español.Los resultados arrojaron un total de 68 publicaciones de T.O. y...

  10. Il Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze

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    Giancarlo Francini

    2013-12-01

    Full Text Available Nel corso del presente articolo vengono descritte le premesse epistemologiche e le metodologie adottate dagli operatori del Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze (ITFF nel lavoro con la popolazione migrante ed elencati gli interventi fatti nel territorio. Il Servizio Intercultura dell’ITFF si è interrogato in questi anni sul valore della cultura come porta d’ingresso nel rapporto con il migrante; nel chiedere loro di narrare aspetti della loro cultura condividiamo aspetti della nostra cultura. L’incontro con il malinteso, che come dice Jankelevitch «(… è un quasi niente» (Jankelevitch, 1987, p. 233, perché se fosse stato qualcosa di più ce ne saremmo accorti e se fosse qualcosa di meno non sarebbe significativo, ci permette di aprirci a un rapporto che cambia entrambi, operatore e migrante, nella relazione. È nella relazione e attraverso il racconto dell’evento migrazione e del ciclo di vita che si costruisce e si cerca un linguaggio comune per la descrizione e l’espressione del disagio. Il lavoro con i migranti deve fare i conti con le difficoltà legate all’impiego, alla casa, al permesso di soggiorno e non ultimo alla brevità di alcuni incontri, perché per alcuni la nostra città è solo una tappa di un percorso che continua alla ricerca di una sistemazione migliore. Nel territorio di Firenze sono stati messi a punto una serie di servizi: oltre alla clinica e a uno sportello di consulenza, ci si dedica alla formazione degli operatori che lavorano con i migranti. Esempi di queste attività sono: un progetto di peer tutoring in alcune scuole superiori, uno di formazione per le assistenti sociali al fine di proporre un protocollo più efficace di presa in carico dei migranti, una serie di focus group con dipendenti Asl all’interno del progetto “Mamma segreta” della regione Toscana; inoltre, la collaborazione con le associazioni presenti sul territorio ha permesso un contatto

  11. Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131 KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

    International Nuclear Information System (INIS)

    Sultana, Asma; Garvey, Conall; Sutton, Robert; Neoptolemos, John P; Ghaneh, Paula; Shore, Susannah; Raraty, Michael GT; Vinjamuri, Sobhan; Evans, Jonathan E; Smith, Catrin Tudur; Lane, Steven; Chauhan, Seema; Bosonnet, Lorraine

    2009-01-01

    Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage. However the drawback is the accompanying systemic toxicity, which targeted treatments may overcome. This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal antibody, labelled with I 131 in pancreatic cancer (ISRCTN 16857581). Patients with histological/cytological proven inoperable adenocarcinoma of the head of pancreas were randomised to receive KAb 201 via either the intra-arterial or intravenous delivery route. The dose limiting toxicities within each group were determined. Patients were assessed for safety and efficacy and followed up until death. Between February 2003 and July 2005, 25 patients were enrolled. Nineteen patients were randomised, 9 to the intravenous and 10 to the intra-arterial arms. In the intra-arterial arm, dose limiting toxicity was seen in 2/6 (33%) patients at 50 mCi whereas in the intravenous arm, dose limiting toxicity was noted in 1/6 patients at 50 mCi, but did not occur at 75 mCi (0/3). The overall response rate was 6% (1/18). Median overall survival was 5.2 months (95% confidence interval = 3.3 to 9 months), with no significant difference between the intravenous and intra-arterial arms (log rank test p = 0.79). One patient was still alive at the time of this analysis. Dose limiting toxicity for KAb201 with I 131 by the intra-arterial route was 50 mCi, while dose limiting toxicity was not reached in the intravenous arm

  12. Clinical outcome during the peri-operative (thyroidectomy) period of severely hyperthyroid patients with normalized pre-operative free-T4 levels: Importance of I-131 therapy as a part of pre-operative preparation

    International Nuclear Information System (INIS)

    Siguan-Crisaldo, M.A.L.; Mercado-Asis, L.B.

    2005-01-01

    Thyroidectomy is performed for hyperthyroidism on patients who do not respond to or are not compliant with medical therapy and in patients with very large goiters causing compressive symptoms. All thyrotoxic patients undergoing thyroidectomy usually are first treated with anti-thyroid drugs to normalize free thyroid hormone levels and render them euthyroid before surgery in order to prevent complications particularly thyroid storm and circulatory collapse. In this case series, we describe the clinical outcome during the perioperative (thyroidectomy) period of three severely hyperthyroid patients, two females and one male, with ages ranging from 13 to 38 years. All patients had grade III goiter, and only one had exophthalmos. The mean duration of goiter was 3.6 years. All of them were given preoperative treatment consisting of propylthiouracil (PTU) at 450-600 mg/day; iodone, 3 tablets daily and propranolol at 30-120 mg/day for one month. All of them had normalized preoperative thyroid function tests. In addition to the preoperative medications mentioned above, all three patients received radioactive iodine therapy before surgery. The first two patients received relatively low doses of 8.0 and 7.5 mCi of I-131 respectively. Unfortunately the first patient had supraventricular tachycardia (SVT), post skin cutting and the other one went into thyroid storm. The third patient who received a cumulative dose of 23.5 mCi of I-131 before surgery had an uneventful postoperative course. It is concluded that normalization of thyroid hormone parameters, especially free T4 is not sufficient for an uneventful and uncomplicated peri-thyroidectomy period in severely hyperthyroid patients with large goiters. Effective radioactive iodine therapy might prove to be helpful in inducing thyroid tissue fibrosis, thus leading to true clinical euthyroidism and excellent clinical course postoperatively. (author)

  13. Capítulo 15. Seguimiento al paciente con dispositivos de estimulación cardiaca

    Directory of Open Access Journals (Sweden)

    Clara I. Saldarriaga

    2016-03-01

    Conclusión: Los pacientes con cardiorresincronizador y desfibrilador implantable deben seguirse en clínicas de falla cardiaca para garantizar la adecuada selección de los candidatos y la optimización de la terapia.

  14. Terapias complementarias en los cuidados: Humor y risoterapia Complementary therapies in the cares: humour and laugh

    Directory of Open Access Journals (Sweden)

    M. Carmen Ruiz Gómez

    2005-06-01

    Full Text Available Dentro de las terapias complementarias, la utilización de la risoterapia aporta beneficios tanto en la salud como en las situaciones de enfermedad, siendo un "instrumento de cuidados" barato y sin efectos secundarios. La tendencia actual hacia todo lo natural, las corrientes sobre cuidados de salud de las distintas culturas, unidas a las recomendaciones de la OMS a los enfermeros sobre la necesidad de utilizar los "métodos tradicionales y complementarios" para conseguir mejorar la salud de la población, hacen que la risoterapia sea una alternativa como instrumento opcional de cuidados. Planteamos una revisión bibliográfica con el objetivo de conocer la aplicación de la risoterapia en la salud y más concretamente en los cuidados enfermeros. Del análisis de los resultados podemos concretar que la risa se trabaja en diferentes ámbitos profesionales, no sólo en el sanitario. Es en el campo de la comunicación donde más se divulga esta terapia. Hemos encontrado pocas publicaciones de enfermería, pero muy valiosas ya que trabajan en el terreno de la investigación y de la docencia. Sería interesante que los profesionales de enfermería utilizaran esta terapia que mejora la calidad de los cuidados y ofrece un campo independiente propicio para la investigación.Related to complementary therapies, humour and laugh contribute to enhance health status and diminish illness situations. Humour as a therapy is an inexpensive tool in the patient care and it has not secondary effects in most cases. Current tendencies, either about natural ways to health or believes on health care of popular cultures, and who recommendations to patients in the use of traditional and complementary methods to improve population health, make humour and laugh an alternative therapy as an optional care tool. We have reviewed the literature with the aim of recognize the application of humour therapy on health and more specifically on nurse cares.On the basis of the review

  15. Farmacocinética y farmacodinamia de antimicrobianos: a propósito de pacientes con neutropenia y fiebre

    OpenAIRE

    Garzón, Javier R; Cuervo M, Sonia; Gómez R, Julio; Cortés, Jorge A

    2011-01-01

    La neutropenia febril es una complicación grave de la terapia antineoplásica que se presenta más frecuentemente en pacientes con neoplasias hematológicas, asociada a tasas elevadas de mortalidad. Uno de los factores descritos como causa de fracasos terapéuticos de la terapia antimicrobiana es la inadecuada concentración tisular de los antimicrobianos que a su vez se correlaciona con bajas concentraciones en el líquido intersticial en el caso de los fármacos hidrofílicos. En pacientes críticam...

  16. Impact of inappropriate antimicrobial therapy on patients with bacteremia in intensive care units and resistance patterns in Latin America Impacto de la terapia antimicrobiana inapropiada en pacientes con bacteriemia en unidades de cuidado intensivo y patrones de resistencia en América Latina

    Directory of Open Access Journals (Sweden)

    J. A. Cortés

    2010-09-01

    Full Text Available Patient care in an intensive care unit (ICU is associated with an increased risk of developing nosocomial infections. Bacteremia is responsible for a great number of cases, 23% of which have attributable mortality in developed countries and can affect up to 52% of ICU patients. The main cause of mortality is inadequate and inappropriate antimicrobial empirical therapy. The incorrect use of antimicrobials is a major risk for identifying multidrug resistant microorganisms, thereby involving increased morbidity, mortality and costs. Implementing several surveillance systems and becoming acquainted with resistance patterns represent a valuable tool for identifying, preventing and treating this infectious complication. There is paucity of data regarding antimicrobial resistance in bacteremic patients in Latin America, and the available data reveals a worrying scenario.El manejo médico en la unidad de cuidado intensivo (UCI se asocia con un mayor riesgo de infecciones intrahospitalarias. Las bacteriemias tienen una alta frecuencia en dichas unidades, se presentan hasta en el 52% de los pacientes allí asistidos y en los países desarrollados se les atribuye una mortalidad del 23%, que se debe fundamentalmente al uso de tratamiento empírico inadecuado o inapropiado. El uso incorrecto de los antimicrobianos es uno de los principales factores de riesgo para el desarrollo de la resistencia bacteriana, que conlleva la selección de microorganismos multirresistentes, el aumento de la morbilidad y la mortalidad y el incremento en los días de estancia hospitalaria y del costo por hospitalización. La implementación de diferentes sistemas de vigilancia y el conocimiento de la variabilidad en la resistencia a los antimicrobianos constituyen valiosas herramientas para identificar y prevenir la resistencia a los antibióticos y para orientar la terapéutica. En América Latina disponemos de pocos datos sobre las tasas de resistencia y aquellos disponibles

  17. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  18. Terapia biológica en enfermedades reumatológicas

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    Manuel F Ugarte-Gil

    2013-04-01

    Full Text Available El advenimiento del uso de terapias biológicas en Reumatología ha modificado significativamente el pronóstico de pacientes portadores de artritis reumatoide (AR, artritis juvenil (AJ, espondilitis anquilosante (EA, entre otras enfermedades. A diferencia de las terapias convencionales estos productos biológicos se dirigen a los llamados blancos terapéuticos ya sea estas una línea celular, un mediador inflamatorio o un receptor de superficie. Estos compuestos son producidos por células vivas mediante la tecnología del ADN recombinante. Estos compuestos pueden tener componentes humano y animal [quiméricos (Xi, humanizados (Zu], o completamente humanos (H lo cual se reconoce por las letras que se incluyen en el nombre de cada uno. En el campo de la Reumatología, el primer compuesto utilizado fue el etanercept (anti-factor de necrosis tumoral o anti-TNF aprobado en 1998, pero otros anti-TNF han demostrado su beneficio en AR, como en EA y AJ. Los inhibidores de Interleucina (IL-1 casi no se usan en AR actualmente, pero si los inhibidores de IL-6, así como los agentes contra las células B y los agonistas de CTLA-4 (Cytotoxic T lymphocyte antigen. Existe asimismo un compuesto dirigido al BLyS (B-lymphocyte stimulator el cual se usa en lupus eritematoso sistémico y otro dirigido al receptor activador del factor nuclear κB (RANKL, receptor activator of nuclear factor-κB ligand que se usa en osteoporosis. Con el avance en el conocimiento de la patogenia de las enfermedades reumαticas, se vienen reconociendo otra blancos terapιuticas. En los aρos venideros, este campo ha de expandirse en proporciones geomιtricas

  19. Nuevas terapias en el tratamiento del VIH

    OpenAIRE

    Garrido Estévez, Julieta

    2017-01-01

    Desde hace décadas, los avances en el tratamiento del VIH han conseguido controlar la infección y disminuir su progresión hacia SIDA. La eliminación del VIH, virus capaz de evadir e incapacitar al sistema inmune, que es el que nos protege de otras infecciones, es en la actualidad uno de los retos más importantes en la investigación científica, pretendiendo con ello las ansiadas prevención y curación de la enfermedad. Objetivo: Definir la situación actual del tratamiento de la infección por...

  20. Terapia hormonal y calidad del hueso Hormone therapy and bone quality

    Directory of Open Access Journals (Sweden)

    2005-08-01

    Full Text Available La osteoporosis se reconoce como uno de los problemas de salud de la población femenina posmenopáusica, y la terapia hormonal de reemplazo (THR como una de las medidas terapéuticas efectivas para evitar la fractura. Nos propusimos mostrar la experiencia acumulada en relación con el efecto de la terapia hormonal de reemplazo sobre la calidad del hueso. En un estudio retrospectivo realizado en 42 mujeres con edades entre 40 y 59 años que asistieron a la Clínica de Climaterio y Osteoporosis y a la consulta multidisciplinaria de climaterio del Hospital Ginecoobstétrico “Ramón González Coro” entre enero de 1997 y diciembre del año 2003, se determinó la calidad ósea mediante absorciometría dual de rayos X en región lumbar (L2-L4 o por ultrasonido del calcáneo (USCAL y recibieron tratamiento continuado con terapia estrogénica (E o con estrógenos progestagenos (EP durante no menos de un año (n = 30. Las mujeres que no pudieron recibir THR fueron agrupadas y evaluadas como grupo control (n =12. Durante el tiempo de observación promedio de 2 años, las mujeres que recibieron THR mejoraron su calidad ósea en el 16,8 %, mientras que las del grupo control empeoraron en el 8 % de los casos. Estos resultados iniciales, aunque son modestos, muestran la utilidad de la THR para mejorar la calidad del hueso y la necesidad de continuar estudios que permitan definir en nuestro medio la persistencia de la mejoría ósea, así como la magnitud de la osteoporosis posmenopáusica.Osteoporosis is recognized as one of the health problems of the female postmenopausic population and the replacement hormone therapy (RHT as one of the effective therapeutical measures to prevent fracture. We proposed ourselves to show the experience accumulated in relation to the effect of the replacement hormone therapy on the bone quality. In a retrospective study conducted among 42 women aged 30-59 that attended the Climacteric and Osteoporosis Clinic and the

  1. pacientes con insuficiencia renal terminal

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    Karen Herrera Herrera

    2011-01-01

    Full Text Available La presente investigación fundamenta en la clínica psicoanalítica el estudio de dos casos de tres personas diagnosticadas con IRT que reciben tratamiento de hemodiálisis, en razón a que dadas las características y el aumento de los reportes que se presentan, ya esto se considera un problema de salud pública. El objetivo principal es describir las características dinámicas del proceso de duelo en pacientes con IRT en un centro de terapia renal de la ciudad de Cartagena. El procedimiento metodológico empleó un diseño de tipo cualitativo; la investigación se desarrolló con un diseño clínico mediante el estudio de casos, y fundamentada en la hermenéutica psicoanalítica. Todo esto respaldado en la historia clínica, la entrevista semiestructurada individual y familiar, los test proyectivos, test del dibujo de la figura humana Machover y TAT de Murray, para la debida integración de los análisis. Se concluye que predominan funciones fallidas de los progenitores y que son individuos provenientes de familias psicosomáticas, que utilizan la enfermedad para obtener un beneficio secundario.

  2. LA TERAPIA CELULAR EN EL TRATAMIENTO DE LA ISQUEMIA CRÍTICA DE EXTREMIDADES INFERIORES

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    Gallardo Y

    2006-07-01

    Full Text Available ABSTRACT:Critical limb ischaemia is the final phase of the peripheral arterial disease. The treatment consists of the revascularización, but sometimes, the medical treatment is the only therapeutic option before the amputation. The cellular therapy allows the possibility of dealing with diseases with the use alive cells. This paper is a review about the utilization of adult staminal cells in patients with critical limb ischaemia.RESUMENLa isquemia crítica de la extremidad es la fase final de la enfermedad arterial periférica. El tratamiento consiste en la revascularización, pero en ocasiones, el tratamiento médico es la única opción terapéutica antes de la amputación. La terapia celular permite la posibilidad de tratar enfermedades con el uso de células vivas. En este artículo se efectúa una revisión del uso de células madre adultas en pacientes con isquemia crítica de la extremidad.

  3. TERAPIA DE INTERACCIÓN PADRES-HIJOS (PCIT

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    Rafael Ferro García

    2014-09-01

    Full Text Available La Terapia de Interacción Padres-Hijos (PCIT es una terapia breve para tratar los problemas de conducta en la infancia. Es un tratamiento que está demostrado válido empíricamente y puede ser considerada como un tratamiento bien establecido para tratar conductas problema en la infancia según las normas de la APA. Este trabajo expone sus características principales, sus componentes clínicos, y los factores que afectan a la efectividad. Hace una revisión de la literatura existente de las investigaciones sobre su efectividad y eficacia. También, se exponen las últimas adaptaciones en diferentes contextos, formatos, problemas y distintas poblaciones.

  4. Cuidado paliativo e enfermeiros de terapia intensiva: sentimentos que ficam

    OpenAIRE

    Silveira, Natyele Rippel; Nascimento, Eliane Regina Pereira do; Rosa, Luciana Martins da; Jung, Walnice; Martins, Sabrina Regina; Fontes, Moisés dos Santos

    2016-01-01

    RESUMO Objetivo: conhecer os sentimentos dos enfermeiros acerca dos cuidados paliativos em unidades de terapia intensiva de adultos. Método: estudo qualitativo, cujo referencial teórico adotado foi o das Representações Sociais, realizado com 30 enfermeiros do estado de Santa Catarina incluídos por amostragem Bola de Neve. Os dados foram coletados por meio de entrevistas semiestruturadas realizadas de abril a agosto de 2015, organizados e analisados por meio do Discurso do Sujeito Coletivo. ...

  5. Tendencias actuales y futuras de la terapia de familias

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    Francisco Almagro Domínguez

    1996-06-01

    Full Text Available Se exponen brevemente la situación actual y las perspectivas de la terapia familiar a partir de la información obtenida en el Séptimo Congreso de IFTA (International Family Therapy Association, celebrado en Guadalajara, México, en Octubre de 1995. Los criterios actuales abarcan desde el ciclo vital y las técnicas nuevas, hasta el tratamiento familiar del SIDA y el cáncer. El futuro se considera, en general, promisorio para estas terapias. Se habla de relacionar diagnósticos, enseñanza integrada a planes de estudio y entrenamiento de personal comunitario; todo ello como perspectiva de la terapia de familiasThe present situation and the outlooks of family therapy based on the information obtained at the 7th Congress of the International Family Therapy Association, held in Guadalajara, Mexico, in October, 1995, are briefly explained. New criteria embrace from the vital cycle and the new techniques to the family treatment of AIDS and cancer. In general, the future is considered as promising for these therapies. It is talked about relating diagnoses, integrating teaching to curricula, and training community personal; all of it as a prospect of family therapy.

  6. Terapia comportamental cognitiva: uma comparação entre perspectivas

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    Rachel Rodrigues Kerbauy

    Full Text Available A Terapia Comportamental Cognitiva desenvolveu-se a partir de dados e maneiras de trabalhar da Terapia Cognitiva e da Terapia Comportamental. Essas origens e as várias influências parecem determinar maneiras diferentes de conduzir a terapia o que se procurou analisar neste trabalho. Optou-se pela apresentação do trabalho de três autores: Ellis, Beck e Meichembaum como representativos da área embora se reconheça que há diferenças entre algumas concepções e também unanimidade na explicação de comportamentos, especialmente emocionais.

  7. Úlcera venosa e terapia compressiva para enfermeiros: desenvolvimento de curso online Úlcera venosa y terapia compresiva para enfermeros: desarrollo de un curso online Venous ulcer and compression therapy for nurses: development of online course

    Directory of Open Access Journals (Sweden)

    Fernanda Mateus Queiroz

    2012-01-01

    Full Text Available OBJETIVO: Descrever a elaboração de um curso on-line sobre úlcera venosa, com enfoque em terapia compressiva, para capacitação de enfermeiros. MÉTODOS: O desenvolvimento do curso on-line seguiu as fases de análise, design, desenvolvimento, implementação e avaliação, baseadas no design instrucional contextualizado. RESULTADOS: O curso dividiu-se em dez módulos estruturados no ambiente virtual de aprendizagem Moodle. Caracterizou-se por uma proposta construtivista, visando ampliar a participação do aluno, disponibilizar as principais referências, revisões e consensos, bem como utilizar objetos multimídia e recursos didáticos interativos. CONCLUSÃO: O curso possibilita a capacitação profissional do enfermeiro em terapia compressiva de maneira inovadora, flexível, interativa em diversos ambientes de cuidado.OBJETIVO: Describir la elaboración de un curso online sobre úlcera venosa, con enfoque en terapia compresiva, para la capacitación de enfermeros. MÉTODOS: El curso online se desarrolló siguiendo las fases de análisis, diseño, desarrollo, implementación y evaluación, basadas en el diseño instruccional contextualizado. RESULTADOS: El curso se dividió en diez módulos estructurados en el ambiente virtual de aprendizaje Moodle. Se caracterizó por una propuesta constructivista, pretendiendo ampliar la participación del alumno, poner a disposición las principales referencias, revisiones y consensos, así como utilizar objetos multimedia y recursos didácticos interactivos. CONCLUSIÓN: El curso permite la capacitación profesional del enfermero en terapia compresiva de manera innovadora, flexible, interactiva en diversos ambientes de cuidado.OBJECTIVE: To describe the development of an online course about venous ulcer, with a focus on compression therapy, for the educating of nurses. METHODS: The development of an online course followed the phases of analysis, design, development, implementation and evaluation, based

  8. Determination of Therapeutic Dose of I-131 for First High Dose Radioiodine Therapy in Patients with Differentiated Thyroid Cancer: Comparison of Usefulness between Pathological Staging, Serum Thyroglobulin Level and Finding of I-123 Whole Body Scan

    International Nuclear Information System (INIS)

    Jeong, Hwan Jeong; Lim, Seok Tae; Youn, Hyun Jo; Sohn, Myung-Hee

    2008-01-01

    Recently, a number of patients needed total thyroidectomy and high dose radioiodine therapy (HD-RAI) get increased more. The aim of this study is to evaluate whether pathological staging (PS) and serum thyroglobulin (sTG) level could replace the diagnostic I-123 scan for the determination of therapeutic dose of HD-RAI in patients with differentiated thyroid cancer. Fifty eight patients (M:F=13;45, age 44.5±11.5 yrs) who underwent total thyroidectomy and central or regional lymph node dissection due to differentiated thyroid cancer were enrolled. Diagnostic scan of I-123 and sTG assay were also performed on off state of thyroid hormone. The therapeutic doses of I-131 (TD) were determined by the extent of uptakes on diagnostic I-123 scan as a gold standard. PS was graded by the criteria recommended in 6th edition of AJCC cancer staging manual except consideration of age. For comparison of the determination of therapeutic doses, PS and sTG were compared with the results of I-123 scan. All patients were underwent HD-RAI. Among them, five patients (8.6%) were treated with 100 mCi of I-131, forty three (74.1%) with 150 mCi, six (10.3%) with 180 mCi, three (5.2%) with 200 mCi, and one (1.7%) with 250 mCi, respectively. On the assessment of PS, average TDs were 154±25 mCi in stage I (n=9), 175±50 mCi in stage II (n=4), 149±21 mCi in stage III (n=38), and 161±20 mCi in stage IV (n=7). The statistical significance was not shown between PS and TD (p=0.169). Among fifty two patients who had available sTG, 25 patients (48.1%) having below 2 ng/mL of sTG were treated with 149±26 mCi of I-131, 9 patients (17.3%) having 2≤ sTG <5 ng/mL with 156±17 mCi, 5 patients (9.6%) having 5≤ sTG <10 ng/mL with 156±13 mCi, 7 patients (13.5%) having 10≤ sTG <50 ng/mL with 147±24 mCi, and 6 patients (11.5%) having above 50 ng/mL with 175±42 mCi. The statistical significance between sTG level and TD (p=0.252) was not shown. In conclusion, PS and sTG could not replace the

  9. ALCOOLISMO NO CONTEXTO FAMILIAR: ESTRATÉGIAS DE ENFRENTAMENTO DAS IDOSAS USUÁRIAS DA TERAPIA COMUNITÁRIA

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    Maria de Oliveira Ferreira Filha

    2012-01-01

    Full Text Available El alcoholismo en el contexto familiar genera daños significativos a la mujer anciana que se torna la víctima más evidente de esta problemática. Estudio documental, realizado en la Secretaria de Salud de João Pessoa, Paraíba, en julio/2008, con objetivo de identificar estrategias utilizadas por las ancianas para enfrentarse al alcoholismo en la familia y las hablas espontáneas expresadas en el último momento las ruedas de la terapia. Fueron consultadas 776 fichas de informaciones de la terapia comunitaria integradora. Los hallazgos fueron organizados en narraciones y divididos en categorías de análisis. Las estrategias más utilizadas fueron: espiritualidad (33,3%, grupos de autoayuda (26,6% y fortalecimiento de las familias (13,3%; y las hablas más frecuentes: coraje (15,5%, esperanza (13,3%, fe (11,1%, confianza y unión (6,6%. La relación entre los resultados apunta como efecto positivo el empoderamiento, fortalecimiento de lazos y la resiliencia, permitiendo a la familia la superación de los dilemas cotidianos delante del alcoholismo.

  10. Análisis coste-efectividad de la adhesión inicial a la terapia antirretroviral entre individuos infectados por el VIH en Belo Horizonte, Brasil

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    Francisco de Assis Acurcio

    2006-01-01

    Full Text Available Fundamento: En Brasil, los antirretrovirales (ARV se distribu- yen a los portadores de VIH de forma gratuita por el Sistema Único de Salud. La adhesión al tratamiento es una de las principales variables en la cual los servicios de salud pueden intervenir para aumentar la efec- tividad de la medicación. El objetivo del estudio es evaluar la relación coste-efectividad de la adhesión inicial a la terapia ARV e identificar factores que influencien los costes y la evolución global del paciente. Métodos: Estudio prospectivo con individuos infectados por el VIH reclutados, después de la primera prescripción de ARV, en dos servicios públicos de referencia para el tratamiento del VIH/Sida en Brasil. La no-adhesión fue definida como la utilización 200 cels/mm3 y ser adherente al tratamiento AR Conclusiones: Los resultados observados sostienen la terapia AR V como una intervención coste-efectiva. Sin embar go, la baja adhesión aumenta los riesgos de fallo terapéutico y de progresión de la enfermedad, que resultan en un impacto negativo sobre la relación coste-efectividad de la terapia AR V.

  11. Alcoholismo: integración familia-paciente desde la terapia ocupacional = Alcoholism : family integration - patient from the occupational therapy

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    Santi, A S

    2006-09-01

    Full Text Available RESUMEN El propósito del presente trabajo es reconocer al alcoholismo como una enfermedad, una adicción, que tiene repercusión a nivel individual y social. Intentando, específicamente hacer hincapié en la integración de la familia en el tratamiento del paciente con dependencia al alcohol.La metodología utilizada es la consideración de un caso clínico concreto, un paciente alcohólico asistido bajo abordaje individual por Terapia Ocupacional, durante tres meses en una institución de salud mental en condición de internado, estableciendo los puntos en común con la bibliografía existente. Se trata de articular la teoría con la práctica.Como consecuencia de lo investigado y vivenciado, como practicante de Terapia Ocupacional, se concluye que la familia es un elemento importante a la hora de lograr la predisposición del paciente alcohólico en proceso de rehabilitación al tratamiento. Donde Terapia Ocupacional es una disciplina que cumple un rol privilegiado dentro de dicho proceso, como facilitadora de las herramientas prácticas concretas, a nivel individual y familiar.Así la familia, sistema de transmisión de cultura y sostén de sus miembros, se convierte en un recurso indispensable en la recuperación del alcoholismo, si es considerada oportunamente.ABSTRACT This work aims to recognize alcoholism as an illness and an addiction having repercussions on individual and social aspects, and to try to make a special point of the family integration in the treatment of the alcoholic patient.So that, the family is viewed as an element for the support of its members and a way of transmitting culture which can be an essential resource for the recovery of alcoholic patients.The method consists of considering an specific clinical case, an alcoholic patientindividually treated with Occupational Therapy during 3 months as an internee in a Mental Health Institution, and finding at the same time common points with the existing bibliography and

  12. Factores asociados al estadio clínico avanzado en el inicio de la terapia antirretroviral

    Directory of Open Access Journals (Sweden)

    Eduardo Warley

    2012-10-01

    Full Text Available A fin de evaluar la frecuencia y posibles factores asociados a la presencia de estadio clínico avanzado al inicio de terapia antirretroviral (ECAITA, efectuamos un análisis retrospectivo de datos de dos cohortes prospectivas de pacientes infectados por HIV que iniciaron terapia antirretroviral (sin tratamiento anterior entre 2005 y 2009. Se analizaron las historias clínicas de 264 pacientes, 123 mujeres (46.6% y 141 hombres (53.4%. La mediana de edad fue de 37.7 años. Observamos ECAITA en 132 casos (50%, de los cuales 102 (77.2% se asociaron a diagnóstico tardío de infección por HIV y 30 (22.8% a pacientes con diagnóstico previo no retenidos en el cuidado clínico de la salud. La mediana de células CD4 fue 120/ml y de carga viral 58 038 copias/ml. El recuento de células CD4 era inferior a 200 cel/ml en 174 pacientes (71.3%. Los hombres presentaron ECAITA con mayor frecuencia que las mujeres (59.8% vs. 40.2%, en quienes el diagnóstico se realizó durante el control de un embarazo en el 25.2% de los casos. Consumo elevado de alcohol (p 0.006, ser soltero (p 0.04 y nivel de educación menor al secundario completo (p 0.008 se asociaron a ECAITA en el análisis bivariado. Ser de sexo masculino (p 0.003 fue el único factor asociado tanto en el análisis bivariado como en el multivariado. Nuestros datos refuerzan la necesidad de expandir el testeo para HIV y deberían impulsar a definir acciones programáticas que promuevan el ingreso precoz al cuidado de la infección por HIV.

  13. Análisis y terapia del comprtamiento en Chile: origenes, estado actual y proyectos

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    Pablo E. Vera-Villarroel

    2010-07-01

    Full Text Available El presente artículo realiza una revisión sobre los orígenes, estado actual y proyecciones del análisis del comportamiento y sus derivaciones en Chile. Su aplicación y entrenamiento sistemático se remonta a la parte final de la década de los sesenta, cuando Sergio Yulis introduce la terapia conductual en los cursos de psicoterapia. Durante los primeros años se realizan variadas aplicaciones tanto en área básica como aplicada. Durante el año 1973 muchos docentes deben abandonar el país, produciéndose un retroceso en el avance de la disciplina. Actualmente la orientación es considerada como una de las escuelas fundamentales en la formación de los futuros psicólogos y otros profesionales de la salud aun cuando no se cuente con la mayor preferencia entre la comunidad psicológica chilena. No existe ni en la formación ni en el país en la actualidad la fuerte presencia del conductismo que existió a finales de los setentaEl presente artículo realiza una revisión sobre los orígenes, estado actual y proyecciones del análisis del comportamiento y sus derivaciones en Chile. Su aplicación y entrenamiento sistemático se remonta a la parte final de la década de los sesenta, cuando Sergio Yulis introduce la terapia conductual en los cursos de psicoterapia. Durante los primeros años se realizan variadas aplicaciones tanto en área básica como aplicada. Durante el año 1973 muchos docentes deben abandonar el país, produciéndose un retroceso en el avance de la disciplina. Actualmente la orientación es considerada como una de las escuelas fundamentales en la formación de los futuros psicólogos y otros profesionales de la salud aun cuando no se cuente con la mayor preferencia entre la comunidad psicológica chilena. No existe ni en la formación ni en el país en la actualidad la fuerte presencia del conductismo que existió a finales de los setenta

  14. Terapia farmacológica en la mujer y prevención cardiovascular

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    Nohora I. Rodríguez-Guerrero

    2018-01-01

    Full Text Available Resumen: La enfermedad cardíaca es la principal causa de mortalidad en mujeres y dentro de estas sobresale la enfermedad coronaria. En las mujeres se posterga cerca de diez años el inicio de la enfermedad cardiovascular comparada con los hombres y la sintomatología así como las comorbilidades son diversas; en Colombia las enfermedades del aparato circulatorio representan la principal causa de mortalidad. Dentro de los factores de riesgo asociados a la enfermedad cardiovascular y con mayor frecuencia en las mujeres se reportaron la inactividad física, la obesidad, las dislipidemias, la hipertensión arterial, la diabetes mellitus y el tabaquismo. La particularidad de las enfermedades cardiovasculares en la mujer ha llevado a que se desarrollen guías específicas de prevención y tratamiento cardiovascular en la mujer, con recomendaciones relacionadas con los estilos de vida, farmacológicas y de intervenciones invasivas. Es claro que existen diferencias de género en cuanto a síntomas, abordaje terapéutico durante el evento coronario agudo y tratamiento en prevención primaria y secundaria y que momentos como la menopausia, marcan un punto de incremento del riesgo cardiovascular, con mayor prevalencia de varios de los factores de riesgo cardiovasculares. En general los medicamentos usados para el manejo de los factores de riesgo en las mujeres son similares a los indicados en la población masculina, sin encontrarse evidencia significativa de diferencias de dosis, beneficios adicionales o efectos colaterales con excepción de los IECA y los ARA2 en el embarazo, los antiagregantes plaquetarios en prevención primaria y la terapia trombolítica en algunos casos. Este artículo pretende describir las principales intervenciones farmacológicas de patologías cardiovasculares en las mujeres. Abstract: Heart disease is the main cause of mortality in women, with coronary disease being the main category. The onset of cardiovascular disease is

  15. Intercomparison Of Activity Measurements Of Co-58, Y-88, Ho-166m, Tc-99m, dan I-131 Between P3KRBiN and Laboratory Within BATAN And Hospitals

    International Nuclear Information System (INIS)

    Nazaroh; Ermi-Juita; Hermawan-Candra

    2003-01-01

    One way to maintain traceability and to keep consistency of the measurement result of radioactivity was intercomparison program. According with Surat Keputusan Kepala BATAN No.73/KA/IV/99, one of tasks and functions of standardization laboratory is to coordinate an intercomparison program of radioactivity measurement. In the year of 2000, intercomparison program of activity measurements between P3KRBiN and 10 laboratories within BATAN and 12 hospitals were carried out. For intercomparison of Co-58, Y-88, and Ho-166m, there were 3 laboratories within BATAN which have more than 50% difference compared with P3KRBiN measurements and for intercomparison of Tc-99m, dan I-131, there were 2 Dose-Calibrators belongs to hospitals which have more than 30% difference compared with P3KRBiN measurements. From that result it can be concluded that intercomparison of activity measurements are very important and needs continuously to maintain traceability and to keep consistency of measurement result. (author)

  16. Barreiras à implementação da Terapia Compressiva Barreras a la implementación de la Terapia Compresiva Barriers to implementation of Compression Therapy

    Directory of Open Access Journals (Sweden)

    Alda Pereira

    2012-03-01

    Panel de Delphi online. Después se desarrolló un estudio transversal descriptivo analítico, mediante la aplicación de cuestionarios construidos con ese fin en una muestra accidental de 241 profesionales de la salud (enfermeros y médicos que trabajan en los Cuidados de Salud Primarios. Con los datos construimos y validamos la escala de Evaluación de Barreras a la Implementación de la Terapia Compresiva en la Úlcera Venosa (ABITCUV. En los resultados destacamos que, en lo que concierne las barreras que constituyen la escala, los profesionales de salud consideraron ser, por orden decreciente de peso/importancia: el déficit de formación, el déficit de recursos materiales y financieros y la ausencia de normas y protocolo de prácticas. Después surgieron el rechazo del cliente, la falta de motivación y el reconocimiento institucional del profesional y la resistencia del profesional al cambio/nuevas prácticas. Esta jerarquización de las barreras hecha por los profesionales reveló ser similar a aquella sugerida por los expertos del Panel de Delphi.Despite the effectiveness of compression therapy in the treatment of venous ulcers being scientifically demonstrated, it is not widely used. The aim of this study was to determine the barriers/ obstacles to its implementation and extensive use. A literature review allowed identification of a set of potential barriers, which were then validated and ranked for burden/importance by experts in leg ulcers via an online Delphi Panel. After this, we developed a cross-sectional descriptive and analytical study, with a convenience sample of 241 healthcare professionals (nurses and doctors in primary health care, using questionnaires constructed for this purpose. Based on the data, we constructed and validated the Assessment of Barriers to Implementation of Compression Therapy in Venous Ulcer scale (ABITCUV. The results indicated that healthcare professionals considered the barriers in following descending order of burden

  17. Efectividad de distintas terapias físicas en el tratamiento conservador de la fascitis plantar. Revisión sistemática

    OpenAIRE

    Ana María Díaz López; Patricia Guzmán Carrasco

    2014-01-01

    Fundamentos: La fascitis plantar es la afección más frecuente de dolor no traumático en el tobillo-pie. Se presenta más en mujeres entre los 40-70 años con comienzo progresivo y difuso en planta del pie o tobillo que poco a poco se agudiza impidiendo la marcha. El objetivo de este trabajo es determinar si las distintas terapias físicas utilizadas en el tratamiento conservador de la fascitis plantar de al menos un mes de evolución son efectivas individualmente y/o combinadas entre sí. Métodos:...

  18. Aplicación tópica de liposomas ultradeformables para terapia fotodinámica contra Leishmaniasis cutánea

    OpenAIRE

    Martinetti Montanari, Jorge Anibal

    2009-01-01

    Martinetti Montanari, J. A. (2009). Aplicación tópica de liposomas ultradeformables para terapia fotodinámica contra Leishmaniasis cutánea (Tesis de Doctorado). Universidad Nacional de Quilmes, Bernal, Argentina. La Leishmaniasis aun en el año 2009 sigue siendo un problema sin solución. Al presente existen 12 millones de personas infectadas en 88 países, con una incidencia de 2.000.000 personas infectadas/año, de las cuales 500.000 sufren leishmaniasis visceral, y el restante millón y medi...

  19. Tratamiento del paciente con artrosis

    Directory of Open Access Journals (Sweden)

    Francisco Vargas Negrín

    2014-01-01

    Full Text Available El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio terapéutico junto con el control de peso, en caso de sobrepeso u obesidad, constituyen el núcleo central del tratamiento. Los autocuidados individuales y por los familiares son fundamentales en el control del día a día del paciente. El uso de terapias físicas, ayudas técnicas (bastón, etc. y de fármacos tipo analgésicos simples, opioides y antiinflamatorios tiene evidencias demostradas en el control del dolor, mejora la funcionalidad y la calidad de vida del paciente y una clara recomendación de uso en el tratamiento de la artrosis. La cirugía conservadora y la de reemplazo articular se indican en los casos en los que no se logran los objetivos terapéuticos en casos concretos.

  20. Ergonomía y Terapia Ocupacional = Ergonomics and Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Guzman Suárez, Olga Beatriz

    2008-02-01

    Full Text Available RESUMENEn éste artículo se dan a conocer algunas de las aplicaciones más importantes de la ergonomía en Terapia Ocupacional, puesto que a pesar de tener un gran reconocimiento en el sector trabajo, en donde hay un mayor predominio de estudio por parte de la ergonomía, aún se desconocen muchas de las actividades que pueden ser realizadas por éstos profesionales. Terapia Ocupacional abarca el estudio de todas las etapas de la vida del individuo, en cuanto a su desempeño ocupacional se refiere, lo cual garantiza un amplio campo de actuación profesional, que permite profundizar e investigar en diversas áreas, para que desde su experiencia y resultados se facilite el aporte a muchos proyectos de investigación que requieren de conceptos que son transversales a diferentes disciplinas y que pueden constituirse en conocimiento nuevo para la sociedad científica. Con la creación del Grupo de Salud Ocupacional y Ergonomía en la Universidad Manuela Beltrán, se pretende “Desarrollar proyectos de investigación en el campo de la ergonomía, aplicables en los contextos: laboral, escolar, social y familiar; que permitan la adaptación de diferentes entornos al ser humano y a su vez mejorar condiciones tendientes al logro de un óptimo desempeño y productividad”[1]. De esta manera, se inician proyectos de investigación con estudiantes de Terapia Ocupacional, cuyos avances han permitido escribir el presente articulo, se espera además la vinculación de otras áreas para su fortalecimiento. ABSTRACTIn this article they bring themselves to light some of the most important applications of the ergonomics in occupational therapy, since in spite of having a great recognition in the work sector, where there is a greater predominance of study on the part of the ergonomics, still many of the activities they do not know themselves that can be carried out for these professionals. The occupational therapy covers the study of all the phases of the life of

  1. New anti-tumour therapies based on the use of radioisotopes; Nuevas terapias antitumorales con radioisotopos

    Energy Technology Data Exchange (ETDEWEB)

    Rey, G.

    2009-07-01

    The fundamental limitation of radiotherapy lies in the need to confine its activity to the target organ or tissue, in order to prevent damage to nearby organs and a loss of efficiency due to dispersal throughout the organism. Now, new radioisotopes that allow these disadvantages to be avoided are being used. (Author)

  2. Department of Homeland Security (DHS I-131)

    Data.gov (United States)

    Social Security Administration — This identifies resident aliens who should have their Supplemental Security Income benefit payment suspended because they have voluntarily left the United States for...

  3. Determination of I-131 in milk samples

    International Nuclear Information System (INIS)

    Fernandez G, I.; Rodriguez C, G.; Quevedo A, J. L.

    1996-01-01

    In our country, in the near future, an isotope center will be in operation, and due to its characteristics, it is possible the discharge of radionuclides to the atmosphere during its normal exploitation, as well as in case of accident. Considering the kind and the concentration of the radioactive material released to the atmosphere, the possible ways of contamination were determined, playing the milk the most significant role, because the Iodine-131 is in the radionuclide inventory of this center, being possible to pass to the food-chain soil-grass-milk, due to the fact that the center is located in a cattle zone. Owing to these facts, it is necessary to rely on a method for determining Iodine-131 that allows to control its presence in milk samples, when the isotope center start to operate. The direct absorption of Iodine-131 in an anionic exchange resin and the subsequent analysis of this resin for gamma spectrometry with a Nal (Tl) detector is a cheap, simple and fast method with a recovery average greater than the 95%. (authors). 5 refs., 3 tabs

  4. Proyecto de factibilidad para la creación de un Centro de Estimulación y Terapia de Lenguaje para niños entre 1 y 5 años, ubicado en Sangolqui, cantón Rumiñahu, provincia Pichincha.

    OpenAIRE

    Salazar Álvarez, María Fernanda

    2012-01-01

    El realizar un proyecto de creación de un centro de estimulación y terapias de lenguaje es una iniciativa propia que nace a raíz de la experiencia de 7 años trabajando con niños de edad pre-escolar, en donde he podido evidenciar que un porcentaje considerable de niños presenta algunos problemas de lenguaje por lo tanto la necesidad que estos niños tienen de recibir estimulación y terapias de lenguaje extras a las que les podemos brindar en casa o en un centro infantil es fun...

  5. Efecto de la hidroterapia en niños y adolescentes con discapacidad: una revisión sistemática

    OpenAIRE

    Agirre Cano, Nerea

    2014-01-01

    RESUMEN: Introducción: La terapia acuática es una forma de terapia física que puede ser empleado para tratar a niños con discapacidad, ya que gracias a sus características únicas ofrece muchas posibilidades que son difíciles de alcanzar en tierra. Objetivo: examinar el efecto de la hidroterapia en niños y adolescentes con discapacidad. Material y métodos: se realizó una revisión sistemática de la literatura científica desde el año 2005 hasta la actualidad. Se utilizaron las siguientes b...

  6. Terapia ocupacional en un hospital general de pacientes agudos = Occupational therapy in a general hospital for acute pacients

    Directory of Open Access Journals (Sweden)

    Ocello, M. G

    2006-09-01

    Full Text Available RESUMEN Desde su creación, el Hospital Provincial “Dr. José María Cullen” posee la característica de ser un hospital de emergencias, sostenido por la Sociedad de Beneficencia y la Hermanas de la Caridad.Su funcionamiento responde a un Modelo Clínico-Asistencial, lo cual influye en la inserción de Terapia Ocupacional debiendo adaptar sus funciones a las características de la Institución.Los marcos de referencia teóricos y programas que se implementandeber ser acordes con las necesidades surgidas de un Hospital General de Agudos y de emergencias.En el Sector de Terapia Ocupacional se desarrolla la actividad docente cumpliendo con los requisitos reglamentados por el Ministerio de Salud de la Provincia de Santa Fe.ABSTRACT Ever since its start the Provincial Hospital “Dr. José María Cullen” is characterised for being an emergency hospital under the guidance of the Benfit Society of Hermanas de la Caridad.Its function responds to a Clinical Assistential Model, which influences the insertion of Occupational Therapy, adapting its functiones to the characteristics of the Institution as and when called for.The theoretical points of reference and programmes that are used must be in accordance with tehe necessities that appear in an Acute and Emergency General Hospital.In the Occupational Therapy Sector the teaching activity is developed as required by rules and regulations of the Ministry of Health for the Province of Santa Fe.

  7. Células madre adultas en la terapia de enfermedades de la retina

    Directory of Open Access Journals (Sweden)

    Rosa María Pérez Guerrero

    2014-11-01

    Full Text Available En los últimos años se han publicado algunos artículos que plantean las posibilidades que puede aportar el uso de la terapia celular para el tratamiento de ciertas retinopatías. El presente trabajo pretende comunicar la factibilidad y seguridad de la implantación de células madre en pacientes con degeneraciones de retina, como la retinosis pigmentaria y la degeneración macular seca relacionada con la edad, a partir de un estudio preliminar, realizado en pacientes atendidos en la consulta de oftalmología del Hospital General Docente “Dr. Ernesto Guevara de La Serna”, en la provincia de Las Tunas, Cuba. Los mismos fueron tratados con implantación de células madre adultas autólogas, procedentes de la médula ósea, y movilizadas a la sangre periférica mediante el factor estimulador de colonias de granulocitos. Se hizo aplicación local por las vías retrobulbar y peribulbar en ambos ojos, e intravitrea solo en el ojo más afectado. El resto de las células obtenidas se inyectó por vía endovenosa. Se trataron 30 pacientes en ambos ojos en el periodo de marzo a agosto del presente año. Las variables analizadas fueron: agudeza visual y complicaciones del método de implante. Se pudo comprobar que la mejoría visual en ellos fue en el ojo del triple implante, aplicación intravitrea. En ningún caso hubo reacciones adversas generales y se presentaron complicaciones locales en dos casos, debido a uveítis anterior ligera en un ojo, después del implante de células madre, con resolución a las 72 horas con colirios esteroideos. El estudio evidenció la seguridad del método aplicado y los resultados obtenidos son alentadores, pues crean nuevas perspectivas que pueden contribuir significativamente al tratamiento de estas retinopatías

  8. Gerenciamento de tecnologia em terapia intensiva Gerenciamiento de tecnología en terapia intensiva Management of technology in Intensive Care Units

    Directory of Open Access Journals (Sweden)

    Cátia Romano Madureira

    2000-12-01

    Full Text Available A vida do paciente no hospital depende dos procedimentos diagnóstico-terapêuticos e cuidado da equipe de saúde, além da qualidade e disponibilidade de fatores como: estrutura física, recursos materiais, humanos e financeiros. A necessidade de otimizar estes recursos e restaurar a saúde, fez surgir as Unidades de Terapia Intensivas (UTI's, cujo projeto deve considerar o ambiente físico e equipamentos clínicos indispensáveis ao cuidar. Objetivando identificar o nível de conhecimento dos profissionais de saúde sobre as informações técnico-operacionais contidas nos manuais dos equipamentos e a percepção dos entrevistados quanto a adequação das instalações físicas e elétricas destas unidades, realizamos um estudo descritivo numa UTI de um hospital público de Salvador. Os resultados mostraram que estas instalações foram consideradas inadequadas ao desempenho seguro de suas atividades, e que a maioria desconhece as especificações técnico-operacionais dos manuais dos equipamentos.La vida del enfermo en el hospital depende de los procedimientos diagnóstico- terapéuticos y del esmero del equipo de salud, además de la calidad y disponibilidad de factores como: organismo físico, recursos materiales, humanos y financieros. La necesidad de mejorar estos recursos y restaurar la salud, hizo surgir las Unidade de Terapia Intensiva (UTIS cuyo proyecto debe considerar el ambiente físico y los equipos clínicos indispensables para el cuidado. Con el objeto de identificar los conocimientos de los profesionales de salud sobre las informaciones técnico-operacionales existentes en los manuales de los equipos y la percepción de los entrevistados en relación con la adecuación de las instalaciones físicas y eléctricas (de estas unidades, hicimos un análisis en una UTI de un hospital general de Salvador. Los resultados mostraron que estas unidades son inseguras para las actividades y que la mayor parte de las personas desconoce las

  9. Los principios de la terapia neural desde los fundamentos del nervismo hasta la neurociencia actual The principles of neural therapy from the foundations of nervism to current neuroscience

    Directory of Open Access Journals (Sweden)

    Faneth Toscano De La Torre

    2012-12-01

    Full Text Available Introducción: La terapia neural es un tipo de medicina alternativa de origen relativamente reciente, por lo cual constituye un sistema médico complejo en construcción. Hasta el momento, no se ha realizado una síntesis conceptual que permita formular los principios teóricos que sustentan su corpus doctrinario como sistema médico complejo. Objetivo: Formular los principios teóricos que sustentan el corpus doctrinario de la terapia neural. Metodología: Se revisó la literatura de la escuela neurofisiológica inglesa, la escuela rusa pavloviana, además de trabajos de investigación en el área de terapia neural, para poder realizar la formulación de los principios con un carácter general y de este modo sustentarlos en premisas que de preferencia cumplieran con las características de inducción cualitativa, las cuales desde la lógica peirceana confieren un alto grado de veracidad y rigurosidad lógico-científica. Resultados: Se realizó una síntesis lógica de las inferencias, de las que se obtuvieron 7 enunciados con el estatuto final de principio. Conclusiones: La descripción de los principios realizada en este trabajo es un aporte para la construcción del corpus doctrinario de la terapia neural como sistema médico complejo. Salud UIS 2012; 44 (2:57-65Introduction: Neural therapy is a type of alternative medicine of relatively recent origin, so is a complex medical system under construction. So far, it has not made a conceptual synthesis that allows formulating the theoretical principles underpinning its doctrinal corpus as complex medical system. Objective: To develop the theoretical principles that underlines the doctrinal corpus of neural therapy. Methodology: Literature review neurophysiological school English Russian Pavlovian school, in addition to research in the area of neural therapy, in order to make the formulation of a general principles and thus sustain them in premises of preference comply with the qualitative

  10. Efecto de la arginina 8%-carbonato de calcio y del fluoruro de sodio al 5% en la reducción de la hipersensibilidad dentinaria post terapia periodontal: ensayo clínico

    OpenAIRE

    Márquez,M; Quintero,A; Sanz,A; Ramírez,V; Inostroza,C; Chaparro,A

    2011-01-01

    Objetivo: El objetivo de este estudio clínico fue evaluar y comparar la eficacia en la reducción de la hipersensibilidad dentinaria de la arginina al 8%-carbonato de calcio, monofluorfosfato (1.450 ppm) en comparación con un grupo control tratado en base a un barniz de flúor (22.600 ppm) y un dentífrico fluorado (1.450 ppm), 3 veces al día durante un minuto, en pacientes con hipersensibilidad radicular en forma inmediata a la terapia periodontal mecánica (medición basal) y a las 4 semanas res...

  11. Efectividad de la terapia de presión negativa en las úlceras de pie diabético. Revisión crítica de la literatura

    OpenAIRE

    Liñeira García, Tamara

    2016-01-01

    El aumento de la esperanza de vida en el último siglo ha generado una población envejecida con problemas de salud crónicos, en ocasiones difíciles de tratar. Entre los problemas de salud crónicos destacan las heridas crónicas, concretamente las úlceras de pie diabético, que suponen un importante problema de salud tanto para las personas que las padecen como para los sistemas sanitarios. Este tipo de heridas crónicas se caracterizan por su difícil manejo con terapias convencionales que en o...

  12. Perfil del paciente con tuberculosis que abandona el tratamiento en Chile: profile of patients in Chile

    OpenAIRE

    TORRES G, ZULEMA; HERRERA M, TANIA

    2015-01-01

    El abandono del tratamiento de la tuberculosis es uno de los factores más importantes que disminuyen la eficiencia de la terapia. Dentro de sus causas se observan factores relacionados con el paciente, con los fármacos y con el sistema de salud. En Chile, el porcentaje de abandono se ha mantenido en torno al 7%, a pesar de las distintas estrategias implementadas para su prevención. Este estudio corresponde al análisis de las auditorías que se realizan en los casos de abandono y busca definir ...

  13. “Soy como un aspirador” Medicina popular, Espiritualidad y New Age en las terapias de un curandero catalán

    Directory of Open Access Journals (Sweden)

    Isabella Riccò

    2016-06-01

    Full Text Available El artículo presenta un estudio de caso de un “curandero” catalán, una figura eclética e interesante. Josep práctica distintos tipos de sanaciones: soluciona los males espirituales a través del trance, tira las cartas, cura la culebrilla (herpes zoster con un cataplasma, distiende los nervios mediante una vela y saca la mala energía de los dedos. Sus terapias son muy heterogéneas y se han ido desarrollando durante los últimos 40 años. El objetivo del texto es acercarse al panorama de la medicina popular catalana, evidenciando las relaciones que ésta tiene con otras tradiciones, como el espiritismo y el New Age. Los primeros resultados nos han permitido vislumbrar el dinamismo del “curanderismo”, su capacidad de adaptación a nuevas tendencias, hábitos y demandas de los pacientes, así como procesos de resignificación y manipulación por parte de quien ejerce estas terapias.

  14. Fatores associados à morte materna em unidade de terapia intensiva

    Directory of Open Access Journals (Sweden)

    Suzanne Vieira Saintrain

    Full Text Available RESUMO Objetivo: Identificar os fatores associados à morte materna em pacientes internadas em unidade de terapia intensiva. Métodos: Estudo do tipo transversal realizado em unidade de terapia intensiva materna. Foram selecionados todos os prontuários de pacientes admitidas no período de janeiro de 2012 a dezembro de 2014. O critério de inclusão foi todas as pacientes obstétricas e puérperas, e o de exclusão as com diagnóstico de mola hidatiforme, gravidez ectópica e anembrionada, e as internadas por causas não obstétricas. Foi realizada análise comparativa entre os desfechos óbito e alta hospitalar. Resultados: Foram incluídas 373 pacientes, com idade entre 13 a 45 anos. As causas de internação na unidade de terapia intensiva foram síndromes hipertensivas relacionadas à gestação, cardiopatias, insuficiência respiratória e sepse; as complicações foram lesão renal aguda (24,1%, hipotensão (15,5%, hemorragia (10,2% e sepse (6,7%. Ocorreram 28 óbitos (7,5%. As causas de óbito foram choque hemorrágico, falência múltipla de órgãos, insuficiência respiratória e sepse. Os fatores de risco independentes para óbito foram lesão renal aguda (OR = 6,77, hipotensão (OR = 15,08 e insuficiência respiratória (OR = 3,65. Conclusão: A frequência de óbitos foi baixa. Lesão renal aguda, hipotensão e insuficiência respiratória foram os fatores de risco independentes associados à mortalidade materna.

  15. Prevenzione delle infezioni ospedaliere in una terapia intensiva

    Directory of Open Access Journals (Sweden)

    G.B. Orsi

    2003-05-01

    Full Text Available

    Obiettivi: sorveglianza delle infezioni ospedaliere (IO nell’unità di terapia intensiva (UTI di un grande ospedale romano.

    Metodi. tutti i pazienti ricoverati nell’UTI tra il 1.1.2000 ed il 31.12.2001 per ›48 ore. Lo studio, applicando le definizioni di caso dei CDC, ha considerato le seguenti infezioni: infezioni polmonari (POL, setticemie (SET, infezioni delle vie urinarie (IVU, infezioni della ferita chirurgica (IFC. Inoltre sono stati valutati eventuali fattori di rischio preesistenti, procedure invasive, isolamento dei microrganismi e loro suscettibilità agli antibiotici.

    Sulla base dei risultati epidemiologici preliminari, dall’ottobre 2000 al marzo 2001 sono stati effettuati una serie di interventi che hanno modificato alcune importanti variabili associate alle IO.

  16. Seguridad de la terapia de interferón alfa 2b recombinante más ribavirina en la hepatitis crónica C

    Directory of Open Access Journals (Sweden)

    Yoan Antonio Sánchez Rodríguez

    2011-03-01

    Full Text Available INTRODUCCIÓN: la hepatitis crónica C ha adquirido rango de pandemia. El virus de la hepatitis C se ha convertido en la causa principal de hepatitis crónica, cirrosis hepática, hepatocarcinoma, y trasplante de hígado a nivel mundial. OBJETIVO: identificar los efectos adversos asociados a la terapia combinada interferón alfa 2b recombinante más ribavirina durante la evolución del tratamiento y hasta 8 semanas después de finalizado, así como los principales efectos asociados a salidas temporales o definitivas de esta terapia. MÉTODOS: estudio de farmacovigilancia cuya serie estuvo conformada por 122 pacientes con hepatitis crónica C atendidos en el Instituto de Gastroenterología desde mayo de 2001 hasta mayo de 2006. Se utilizó interferón alfa 2b recombinante (3 millones de unidades 3 veces por semana más ribavirina (1 000 o 1 200 mg diarios en dependencia del peso corporal durante 48 semanas. RESULTADOS: el 88,5 % del total de casos presentó efectos adversos; de ellos el 79,5 % correspondió al síndrome seudogripal, seguido de manifestaciones hematológicas, neuropsiquiátricas, gastrointestinales, entre otras menos frecuentes. El 6,6 % de la serie presentó salidas temporales del tratamiento por efecto adverso distinto de la anemia y 4 pacientes, salidas definitivas del estudio, tres por anemia hemolítica severa y uno con hipertiroidismo no controlable. CONCLUSIONES: la terapia combinada interferón alfa 2b recombinante más ribavirina resulta segura, donde el mayor número de casos presentó síndrome seudogripal como efecto adverso más frecuente. Las manifestaciones hematológicas asociadas a las salidas definitivas del estudio permitieron recomendar seguimiento estricto de la hemoglobina y profundizar en el diagnóstico y tratamiento de los principales efectos adversos presentes en otros sistemas y asociados a esta terapia.

  17. A terapia comunitária como um novo instrumento de cuidado para saúde mental do idoso La terapia comunitaria como un nuevo instrumento de cuidado para la salud mental del anciano The communitarian therapy as a new instrument of care for elderly mental health

    Directory of Open Access Journals (Sweden)

    Ianine Alves da Rocha

    2009-10-01

    Full Text Available A Terapia Comunitária vem surgindo como uma nova tecnologia de cuidado nos programas de inserção e apoio à saúde mental da população. Esta pesquisa exploratória tem como objetivo identificar o número de grupos de terapia comunitária com idosos no município de João Pessoa - PB, conhecer os principais temas apresentados pelos idosos e as estratégias utilizadas para o enfrentamento das dificuldades e revelar depoimentos relacionados à melhoria da qualidade de vida dos idosos. Os dados foram coletados nas fichas de registro das terapias, analisado numa abordagem quantitativa. Os resultados demonstraram que o problema mais freqüente nos idoso é o estresse, a estratégia de enfrentamento mais utilizada é a espiritualidade. A Terapia Comunitária vem contribuindo para saúde mental do idoso.La Terapia Comunitaria viene surgiendo como una nueva tecnología de cuidado en los programas de inserción y apoyo a la salud mental de la población como un todo. Esta investigación de carácter exploratorio tiene como objetivos: identificar el número de grupos de terapia comunitaria con ancianos en el municipio de João Pessoa, Paraíba, Brasil, conocer los principales temas que presentan los ancianos, así como las estrategias utilizadas para el enfrentamiento de las dificultades revelando las expresiones verbales relativas a la mejoría de la calidad de vida de los ancianos. Los datos fueron levantados en fichas de registro de las terapias, y analizados desde una perspectiva de abordaje cuantitativa. Los resultados demostraron que el problema más frecuente en los ancianos es el estrés, y la estrategia de enfrentamiento más utilizada es la espiritualidad. La Terapia Comunitaria viene contribuyendo para la mejora de la salud mental del anciano.The Communitarian Therapy comes appearing as a new technology of care in the programs of insertion and support to the mental health of the population. This exploratory research aims to identify the

  18. Factores de riesgo de neumonía nosocomial en terapia intensiva. Hospital “Dr. Ernesto Guevara”

    Directory of Open Access Journals (Sweden)

    Yadira Santiesteban Escalona

    2015-11-01

    Full Text Available Se realizó un estudio analítico, de tipo caso control pareados 1:2, para determinar los factores de riesgo de neumonía nosocomial en pacientes ingresados en terapia intensiva del Hospital “Dr. Ernesto Guevara de la Serna” de Las Tunas, en el período de enero de 2010 a diciembre de 2011. El universo fue de 1035 pacientes ingresados en terapia intensiva (UCI, en dicho período, de ellos constituyeron la muestra, denominada “casos”, 56 pacientes que desarrollaron Neumonía Nosocomial durante su estadía en UCI. Para el “control” de los factores de confusión, por cada caso, se parearon dos pacientes sin diagnóstico de neumonía. La información se obtuvo de fuentes secundarias (historias clínicas. A los casos y a los controles se les llenó una planilla de vaciamiento de datos con las variables analizadas. Los datos se procesaron utilizando el paquete de programas estadísticos Epinfo, versión 6. Para el estudio de los factores de riesgo se realizaron análisis univariados, evaluándose: ODDS RATIO, intervalo de confianza y probabilidad. Resultaron ser factores de riesgo para presentar neumonía nosocomial: la intubación endotraqueal, los trastornos de conciencia, el aislamiento de bacilos no fermentadores, citrobacter diversus y/o klebsiella ssp., haber requerido neurocirugía, el uso de tratamiento antibiótico previo, antiácidos anti H2, nutrición parenteral y la estadía en UCI mayor de siete días.

  19. Empleo de la terapia láser en la reparación ósea periapical

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    MARÍA I. GARRIGÓ ANDREU

    1997-06-01

    Full Text Available El efecto bioestimulante de la radiación láser de baja potencia en el tejido óseo, se ha comprobado en cultivos de células y animales de experimentación. El objetivo de esta investigación fue evaluar dicho efecto en la reparación ósea periapical. Se atendieron 40 pacientes que presentaban procesos periapicales crónicos, a los que se les realizó tratamiento pulpo radicular y láser. Para la terapia láser, se útilizó la técnica puntual en el área lesionada y laserpuntura, con depósitos energéticos de 15 J/cm² y 7 J/cm², respectivamente. Los resultados obtenidos demuestran que existió aceleración en los procesos de reparación ósea periapical al utilizar la terapia láser, pues en el 67,5 % de los pacientes atendidos, la misma ocurrió en un período menor a 6 meses después de iniciado el tratamiento.The biostimulant effect of low energy laser radiation on the bone tissue has been tested in cell cultures and experimental animals. The objective of our investigation was to evaluate this effect on the periapical bone reparation. 40 patients received attention and underwent radicular, pulpar, and laser treatment. The acupuncture points technique in the injured area and the laserpuncture were used as part of the laser terapy with energetic depots of 15 J/cm² and 7 J/cm², respectively. The results show that the processes of periapical bone reparation were accelerated, since in 67.5 % of these patients it took place in less than 6 months.

  20. Anormalidades metabólicas en pacientes con infección por VIH

    OpenAIRE

    Rodríguez Carranza, Sandra I.; Aguilar Salinas, Carlos A.

    2004-01-01

    La terapia antirretroviral altamente activa (TARAA) en pacientes con infección por virus de inmunodeficiencia humana (VIH) disminuyó la morbimortalidad del padecimiento, sin embargo, sus efectos sobre el metabolismo de lipoproteínas, carbohidratos y tejido adiposo son causa frecuente de consulta y en el futuro de morbimortalidad. Nuestro objetivo es describir el estado actual del conocimiento sobre la epidemiología, fisiopatología, diagnóstico y tratamiento de estas complicaciones. Se incluye...

  1. Daño medular espinal: tratamiento y posibles usos de la terapia celular

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    Penélope Mantilla F

    2017-12-01

    Full Text Available El daño medular espinal, representa la principal causa de parálisis (total o parcial, que se acompaña de secuelas irreversibles y de gran impacto negativo para el paciente, entorno familiar y laboral. Con el advenimiento y avances en tecnología, técnicas de inmunohistoquímica, citología y bioingeniería, se han podido desarrollar numerosos estudios a nivel experimental, dirigidos a la recuperación de la función vertebro-espinal, con una inmensa gama de resultados, que sirven de asiento a futuras investigaciones en seres humanos. En su mayoría, evalúan funciones motoras y sensitivas durante las 3 fases de la lesión espinal. Para ello se emplean técnicas de implantación de células madre (de origen alogénico, autólogo o xenogénico a través de la inyección intratecal o directa en parénquima nervioso. Los resultados a nivel experimental son alentadores; sin embargo, aún queda mucho por dilucidar en torno a la formación de la cicatriz glial, de los factores inductores que se expresan y su repercusión en humanos. Las directrices actuales en el tratamiento de la lesión espinal, incluyen desde mejoras en las técnicas de inmovilización y traslado pre-hospitalario del paciente lesionado espinal, pasando por el empleo de fármacos (Esteroides, Lazaroides, Calcio antagonistas, diuréticos osmóticos, etc., hasta el uso de estimulación cortical, epidural y nanoimplantes medulares, así como la aplicación de exoesqueletos y de la Terapia Celular. En este artículo se reúnen los resultados de la revisión de estudios con más de 21mil publicaciones (hasta octubre del 2017, donde se han empleado células madre para tratar la lesión medular espinal (traumática.

  2. Análisis y descripción de una base de datos de Terapia Ocupacional: NARIC

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    Casal Acción B

    2005-09-01

    Full Text Available RESUMENNARIC –National Rehabilitation Information Center- agrupa en su portal gran cantidad de información sobre discapacidad y terapia ocupacional. Está organizada en tres secciones de las cuales nos centraremos en Researchers, dividida a su vez en tres: REHABDATA, NIDRR y Naric Knowledgebase.REHABDATA es una base de datos que recoge resúmenes e información bibliográfica relacionada con la investigación en terapia ocupacional desde 1956 hasta la actualidad. Permite seis formas de búsqueda: avanzada, en los campos de los registros, por los términos del tesauro, por títulos de revista y por editor.El National Institute on Disability and Rehabilitation Research (NIDRR financia trabajos de investigación relacionados con incapacidad. A través de esta sección se recuperan mediante diferentes interfaces las referencias de todos estos trabajos.Knowledgebase es una base de datos que cuenta con cuatro tipos de recursos: Organizaciones y servicios, publicaciones periódicas, bases de datos y directorios, y recursos de Internet. La información se divide en cinco apartados: búsqueda simple, avanzada, y tres directorios.ABSTRACTNARIC –National Rehabilitation Information Center- groups in its web great amount of information on disability and occupational therapy. It is organized in three sections of which we will be centered in Researchers, divided as well in three: REHABDATA, NIDRR and Naric KnowledgebaseREHABDATA is a database that gathers summaries and bibliographical information related to the investigation in occupational therapy from 1956 to the present time. It allows six search forms: advanced, in the fields of the records, by the terms of the thesaurus, titles of magazine and publisher.The National Institute on Disability and Rehabilitation Research (NIDRR finances works of investigation related to disability. Through this section the references from all these works are retrieved by different interfaces.Knowledgebase is a database

  3. Efectos del ibandronato sobre el metabolismo óseo y el perfil de riesgo cardiovascular en mujeres con osteoporosis postmenopáusica tratadas previamente con raloxifeno

    OpenAIRE

    Ferrer Piquer, Marta

    2015-01-01

    “Efectos del ibandronato sobre el metabolismo óseo y el perfil de riesgo cardiovascular en mujeres con osteoporosis postmenopáusica tratadas previamente con raloxifeno” La osteoporosis postmenopáusica es un problema sanitario mundial, dado que las fracturas por fragilidad suponen un aumento importante de morbimortalidad así como del coste económico. En los últimos años se han desarrollado nuevas terapias para el tratamiento de la osteoporosis, siendo por el momento los SERMs y los bi...

  4. Therapy with {sup 90}Y microspheres: radiation protection in new medical therapies; Terapia con microesferas de {sup 90}Y: proteccion radiologica en nuevas terapias medicas

    Energy Technology Data Exchange (ETDEWEB)

    Rojo, Ana; Puerta, Nancy, E-mail: arojo@arn.gob.ar [Autoridad Regulatoria Nuclear (ARN), Buenos Aires (Argentina)

    2013-07-01

    Primary liver cancer is one of the most frequent in the world and with a low cure rate. Radioembolization using 90y spheres is a promising treatment of this pathology and involves the percutaneous vascular application of radioisotope-labeled the order of Micron size particles. The advantages of this technique include the permit administered high doses of radiation to small volumes with low relative toxicity, offer the possibility of treating all the liver including microscopic tumors, and finally, the feasibility of combined with other therapies. Radiation protection in new medical therapies requires justification and optimization, as requirements for their implementation. The application of the principle of optimization in the context of the protection of the patient must be the minimum that it can be reasonably reached compatible with the required doses of treatment dose to healthy tissue. With {sup 90}Y microspheres therapy this optimization applies to the activity of 90y which is administered to the patient, and estimation methods are postulated. in this work are analyzed comparatively these methods, described the early physicists, equations and the limitations of each. Finally, it is concluded that the optimal method to be implemented for the evaluation of the activity of {sup 90}Y manage must be based in a voxel dosimetric model specific for each patient, however, the partitional method may be a good alternative if you don't have the tools to apply the method.

  5. Tratamiento de un caso de pedofilia desde la terapia de aceptación y compromiso (ACT

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    Rafael Jiménez Díaz

    2016-09-01

    Full Text Available En este artículo se expone un caso clínico de pedofilia en el que la conducta (masturbación con cierto contenido mental tenía consecuencias tanto positivas como negativas para el cliente. Debido a este conflicto, cuando el cliente experimentaba deseos pedófilos, intentaba controlarlos o evitarlos, empeorando paradójicamente el problema debido a las consecuencias negativas adicionales que el acto de control llevaba consigo, como mostrará el análisis funcional. Como tratamiento se aplicó la terapia de aceptación y compromiso (ACT con el objetivo de que el cliente saliera del círculo vicioso de lucha y rendición respecto a la conducta pedófila mediante la aceptación de sus eventos privados, ya que esta aceptación está al servicio de acciones valiosas. Por último, se propone que la ACT muestra potencial en el tratamiento de este tipo de problemas, ya que, en el caso tratado, produce una disminución del sufrimiento subjetivo experimentado por el cliente y la realización de conductas encaminadas a sus propios valores personales.

  6. La terapia integral conductual de pareja (IBCT). Descripción, técnicas y aplicación

    OpenAIRE

    Barraca, J.

    2013-01-01

    La Terapia Integral Conductual de Pareja (IBCT) es una intervención evolucionada desde la terapia conductual de pareja que desarrollaran Jacobson y Margolin en los añossetenta. Este nuevo modelo de trabajo se inscribe dentro de las terapias de conducta de tercera generación y, como tal, pone un énfasis especial en el concepto de aceptación, que se desarrolla de forma característica y propia para el entorno de la pareja. La terapia aporta una formulación de los problemas de par...

  7. Terapia neural como tratamiento contra el dolor en la displasia mamaria cíclica de grado II Neural therapy as pain-relief treatment in grade III cyclic breast dysplasia

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    Orlando R Expósito Reyes

    2007-09-01

    Full Text Available De enero a diciembre de 2004 se realizó un estudio experimental del tipo ensayo clínico de fase II, controlado y monocéntrico, cuyo objetivo fue evaluar la eficacia de la terapia neural en el tratamiento del dolor como manifestación de la displasia mamaria cíclica de grado II en comparación con la terapéutica convencional. Se estudiaron 240 pacientes, que fueron divididos en 4 grupos según el tipo de tratamiento: con terapia neural (grupo I, con vitamina E (grupo II, con progesterona (grupo III y con antiinflamatorios no esteroideos (grupo IV. Se observó mejoría del dolor en más de 60 % del grupo I y fue similar con el uso de la progesterona. Con los antiinflamatorios no esteroideos y la vitamina E hubo diferencias significativas. Se obtuvieron resultados satisfactorios con el empleo de la terapia neural con procaína al 1 %, por lo que pudimos considerarla eficaz en la terapéutica de esta manifestaciónA controlled monocentered experimental study of phase II clinical assay type was carried out from January to December, 2004 to evaluate the effectiveness of neural therapy in treating pain as manifestation of grade II cyclic breast dysplasia in comparison to the conventional therapy. Two hundred and forty patients were studied. They were divided into 4 groups according to the type of treatment: neural therapy (group I; vitamin E (group II; progesterone (group III; and non-steroidal anti-inflammatory drugs (group IV. Pain relief was observed in over 60 % of patients in group I, a result similar to that of group III (progesterone. There were significant differences in groups treated with non-steroidal anti-inflammatory drugs and Vitamin E. The use of neural therapy based on 1% procaine yielded satisfactory results, so we considered it as an effective therapy for pain relief in grade II breast dysplasia

  8. Methodology to administer therapeutic dose of I-131; Metodologia para administrar dosis terapeutica de I-131

    Energy Technology Data Exchange (ETDEWEB)

    Basteris M, J.; Gomez D, R. [Universidad Autonoma de Yucatan, Facultad de Medicina, Merida, Yucatan (Mexico)

    2007-07-01

    The present work suggests the use of measures guided to eliminate the resulting chronic sialoadenitis of the treatment of the thyroid cancer with Iodine-131, as well as the use of citric fruits to stimulate the salivation, the post-dose administration of liquids to accelerate the gastric emptying avoiding the secondary effects as the vomit is included. (Author)

  9. Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide

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    Rocío Gamboa

    2006-10-01

    Full Text Available Antecedentes: Los estudios sobre riesgo de enfermedad tuberculosa (ET en artritis reumatoide (AR en pacientes no usuarios de terapia biológica son controversiales. Objetivo: Evaluar AR como factor de riesgo independiente para ET. Diseño: Estudio de cohortes no concurrente. Lugar: Red asistencial Hospital Guillermo Almenara Irigoyen, Lima-Perú, hospital docente. Participantes: Pacientes con AR no usuarios de terapia biológica. Intervenciones: Una cohorte de pacientes con AR no usuarios de terapia biológica (cumplimiento de criterios 1987 del ACR fue pareada por edad y género con una cohorte control (pacientes con trastornos no inmunológicos. Se realizó una entrevista personal. El seguimiento para la cohorte AR se inició en el diagnostico de AR y culminó en el momento de la entrevista o en el diagnóstico de ET (los controles fueron seguidos el mismo periodo de tiempo. Se calculó la densidad de incidencia (DI para ET en cada cohorte y el riesgo relativo (RR. La probabilidad de ET de acuerdo al tiempo de enfermedad fue comparada mediante curvas de Kaplan Meier. Se aplicó un modelo de Cox para ajustar drogas y patologías predisponentes (hazard ratio -HR. Principales medidas de resultados: Enfermedad tuberculosa en pacientes con artritis reumatoide. Resultados: La cohorte AR y los controles (667 y 664 pacientes, respectivamente tuvieron 6 940,75 y 6 666,53 personas-año de seguimiento. La edad al diagnóstico de AR fue 46,65 años. Un 29,7% de 195 pacientes AR fueron PPD positivos. Quince pacientes AR y ocho controles desarrollaron ET (DI de 216,1/100 000 y 122,1/100 000 personas/año. El RR para TBC fue 1,8 (IC 95% = 0,8-4,2 y luego del ajuste para drogas y comorbilidades predisponentes de ET, el HR fue 1,69 (IC 95%=0,26-10,93. No hubo diferencia al comparar las curvas de Kaplan Meier (p=0,19. Conclusiones: La incidencia de ET entre los pacientes con AR fue mayor que en los pacientes sin dicha condición; sin embargo, esta diferencia no

  10. Identificazione delle specie batteriche della placca subgengivale quale fattore di rischio per patologie parodontali in donne con variazioni ormonali fisiologiche e parafisiologiche

    OpenAIRE

    Privitera, Salvatore

    2014-01-01

    I principali obiettivi di questo studio sono stati quelli di valutare le implicazioni della menopausa sulla salute orale, nelle pazienti in trattamento con TOS (terapia ormonale sostitutiva) o meno, con particolare riferimento a modificazioni quali-quantitative dei principali batteri patogeni parodontali, che possono portare ad alterazioni dell equilibrio omeostatico del microbiota a favore di alcune specie più frequentemente coinvolte nell eziopatogenesi delle parodontopatie. A tal fine,...

  11. Cuidado paliativo e enfermeiros de terapia intensiva: sentimentos que ficam

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    Natyele Rippel Silveira

    Full Text Available RESUMO Objetivo: conhecer os sentimentos dos enfermeiros acerca dos cuidados paliativos em unidades de terapia intensiva de adultos. Método: estudo qualitativo, cujo referencial teórico adotado foi o das Representações Sociais, realizado com 30 enfermeiros do estado de Santa Catarina incluídos por amostragem Bola de Neve. Os dados foram coletados por meio de entrevistas semiestruturadas realizadas de abril a agosto de 2015, organizados e analisados por meio do Discurso do Sujeito Coletivo. Resultados: os resultados apontaram como ideias centrais estão relacionadas aos sentimentos de conforto, frustração, insegurança e angústia, além do sentimento de que a formação e atuação profissional estão voltados para o curativo. Conclusão: as representações sociais dos enfermeiros acerca dos sentimentos relacionados aos cuidados paliativos estão representadas principalmente por sentimentos negativos, provavelmente consequentes ao contexto em que se dá o cuidado.

  12. Manejo de conductos radiculares con curvatura marcada

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    Jorge Mario Nuñez Duran

    2013-10-01

    Full Text Available Las variaciones anatómicas en dientes con conductos que poseen dilaceraciones hacen del tratamiento de endodonciaun reto o una complicación relativa, en donde el clínico debe desarrollar toda su habilidad y el uso de instrumentosespeciales que faciliten u optimicen la terapia de conductos radiculares. La toma de radiografías previas con diferentesangulaciones y el estudio minucioso de ellas, darán una ayuda fundamental para conocer más detalladamente estacomplicación anatómica, que en algunos casos es muy frecuente. El uso de instrumental más flexible y resistentepermite llegar con mayor precisión y seguridad a la parte apical sin que se corra el riesgo de fracturar los instrumentos,limpiándolos y modelándolos en toda su extensión para poder obturarlos de una manera correcta.El uso de limas de menor calibre, precurvadas, permite acceder a la porción dilacerada de la raíz. Este es un métodoeficaz para prevenir la perdida de longitud de trabajo y evitar así las perforaciones de las raíces durante la preparación.Dentro de los errores más comunes durante la instrumentación de los conductos está la perdida de longitud detrabajo, junto con la transportación del foramen apical, ya sea de manera externa o interna. En el presente artículose menciona el uso de nuevas y mejores técnicas usadas para poder evitar este tipo de errores y se muestra un casoclínico del manejo de un molar superior con una curvatura de 40 grados que fue preparado y obturado exitosamentecon el sistema Protaper (Dentsply- maillefer.

  13. A terapia comunitária em um centro de atenção psicossocial: (desatando pontos relevantes La terapia comunitaria en los centros de atención psicosocial: (desatando nudos relevantes Community therapy at psychosocial care centers: (disconnecting relevant points

    Directory of Open Access Journals (Sweden)

    Maria de Oliveira Ferreira Filha

    2010-06-01

    Full Text Available Este estudo objetiva descrever a implantação da Terapia Comunitária (TC em um Centro de Atenção Psicossocial (CAPS, identificar problemas vivenciados por usuários e familiares e estratégias de enfrentamento, além de analisar a contribuição da Terapia Comunitária para inclusão social do usuário. Consiste num estudo predominantemente qualitativo desenvolvido em um Centro de Atenção Psicossocial. O material foi produzido em 12 rodas de Terapia tendo sido utilizadas a técnica de entrevista semi-estruturada e as fichas de avaliação da TC. Os resultados evidenciaram como problemas principais: conflitos familiares, insônia e abandono. Várias estratégias de enfrentamento foram mencionadas: apoio familiar, crença religiosa e ajuda profissional. Comprovou-se que a participação dos usuários tem contribuído para a inclusão social destes ao relatarem mudanças de comportamento nos relacionamentos interpessoais. A experiência tem mostrado ótimos resultados, pois o estudo trabalha uma abordagem que contempla aspectos sociais ainda negligenciados.Este estudio tiene por objetivo describir la implantación de la Terapia Comunitaria (TC en un Centro de Atención Psico-social (CAPS, identificar problemas vivenciados por los usuarios y sus familiares y las estrategias de enfrentamiento, además de analizar la contribución de la Terapia Comunitaria para la inclusión social del usuario. Es un estudio predominantemente cualitativo desarrollado en un Centro de Atención Psico-social. El material fue elaborado a partir de la realización de 12 ruedas de Terapia, y se utilizaron la técnica de entrevista semi-estructurada y las fichas de evaluación de la Terapia Comunitaria. Los resultados evidenciaron problemas como: conflictos familiares, insomnio y abandono. Se mencionaron varias estrategias de enfrentamiento: apoyo familiar, fe religiosa, ayuda profesional. Se comprobó que la participación de los usuarios contribuyó para la inclusi

  14. La terapia láser de baja potencia en la medicina cubana Low potency laser therapy in Cuban medicine

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    Adel Hernández Díaz

    2008-06-01

    Full Text Available El surgimiento y desarrollo del láser fue posible gracias a los avances previamente logrados en otras disciplinas científicas en el pasado siglo. Desde el punto de vista práctico puede ser considerado como un haz estrecho de luz monocromática y coherente que puede encontrarse en el rango visible, infrarrojo o ultravioleta del espectro de las radiaciones electromagnéticas. Motivados por la incorporación de los equipos láser de producción nacional en las salas de rehabilitación de los policlínicos universitarios de la atención primaria y otros centros de salud del país, nos dimos a la tarea de realizar este trabajo, cuyo objetivo fundamental es presentar las distintas aplicaciones del láser de baja potencia en la medicina, y los equipos láser cubanos disponibles en la red nacional de salud pública. Además se muestran los efectos terapéuticos de la radiación láser y los mecanismos internos para lograrlos, y se detallan ampliamente las contraindicaciones de la terapia. Este tipo de tratamiento ofrece muchas posibilidades de ayuda terapéutica y permite ser utilizado con éxito en patologías de diversas especialidades. La terapia láser constituye un tratamiento de primera línea para muchas de las afecciones con que acuden los pacientes a consulta médica.The appearance and development of laser was possible thanks to the advances previously attained in other scientific disciplines in the last century. From the practical point of view, it may be considered as a narrow monochromatic and coherent beam of light that may be found in the visible infrared or ultraviolet range of the spectrum of electromagnetic radiations. Motivated by the introduction of the laser equipment of national production into the rehabilitation wards of the teaching polyclinics and other health centres of the country, we made this paper aimed at presenting the different applications of low potency laser in the medical sphere, as well as the Cuban laser

  15. Proyecto de intervención enfermera con musicoterapia en la cura de heridas vasculares.

    OpenAIRE

    Maté Lázaro, Mireia

    2017-01-01

    En la actualidad, los pacientes con herida vascular tienen que convivir diariamente con el dolor. El manejo óptimo del dolor es uno de los retos principales para los profesionales de enfermería. Diversos son los tratamientos existentes para la resistencia al dolor y disminución de la ansiedad, pero cada vez se apuesta más por terapias complementarias, como puede ser la Música. Varias investigaciones han demostrado la eficacia de la Música como tratamiento. El objetivo de este estudio es ex...

  16. Trastorno de espectro autista de alto funcionamiento y su relación con la familia

    OpenAIRE

    González Villafáñez, María Felisa

    2014-01-01

    El objetivo de este trabajo consiste en analizar las dificultades que tienen los adolescentes con Trastorno del Espectro Autista de Alto Funcionamiento (TEA-AF), en sus relaciones sociales y familiares. Este análisis ha requerido la revisión de las diversas definiciones y teorías explicativas del citado trastorno. A su vez también se describen las terapias conocidas hasta hoy para crear un programa de apoyo a los familiares (padres, hermanos, abuelos…) que se relacionan con dicho adolescente....

  17. Cultura de seguridad del paciente en la prestación de servicios profesionales de Terapia Ocupacional

    Directory of Open Access Journals (Sweden)

    Olga Peñas Felizzola

    2017-01-01

    Full Text Available Objetivo: Caracterizar el ambiente de seguridad del paciente en un servicio de Terapia Ocupacional donde se desarrollan actividades docentes y asistenciales para el programa de la Universidad Nacional de Colombia. Materiales y m étodos : Estudio descriptivo transversal, con aplicación de la Encuesta sobre clima de seguridad del paciente en servicios del área de la salud (versión para Colombia, adaptada y en formato electrónico, a tres terapeutas ocupacionales vinculadas durante 2013 a 2015 en un escenario docente asistencial de la Universidad Nacional de Colombia. Consulta de reportes y estadísticas del servicio correspondientes al periodo de análisis. Resultados: Entre los hallazgos de la encuesta resaltan el subregistro de eventos, aunque no haya una percepción punitiva frente a su reporte; se percibe comunicación abierta, con necesidad de mejorar la retroalimentación ante los errores; considerable rotación e insuficiencia de personal; se aprecia apoyo institucional al tema; y se evalúa como positivo el aprendizaje organizacional y mejoramiento continuo del servicio. Conclusiones: En términos globales, las profesionales valoran bien el ambiente de seguridad del paciente en el servicio analizado, pero debe trabajarse en pro de los aspectos claves que eviden - ciaron debilidades en las categorías analizadas, donde preocupa la aparente falta de registro de eventos y la consiguiente debilidad para establecer medidas correctivas. Además, es importante capitalizar estas experiencias y procesos sobre gestión de la calidad y seguridad del paciente, articulando con las actividades de formación y docencia que también se llevan a cabo allí.

  18. Studio preliminare sul possibile utilizzo del sistema Uro-Quick per l’esecuzione rapida di antibiogrammi su ceppi provenienti da reparti di terapia intensiva

    Directory of Open Access Journals (Sweden)

    Elisabetta Pezzati

    2005-06-01

    Full Text Available L’Uro-Quick, un sistema automatizzato ampiamente utilizzato per lo screening delle batteriurie sui campioni d’urina, è stato precedentemente impiegato per la valutazione della sensibilità agli antibiotici negli uropatogeni e per l’identificazione di resistenze ben caratterizzate veicolate da diverse specie batteriche. In questo studio sono stati esaminati utilizzando la metodica classica Kirby-Bauer per la determinazione dell’antibiotico sensibilità patogeni isolati durante il periodo settembre 2003 - marzo 2004 in reparti di terapia intensiva di un grande ospedale italiano e i risultati sono stati confrontati con quelli ottenuti con il nuovo sistema rapido Uro-Quick. L’antibiotico (in concentrazione appropriata è stato introdotto in una cuvetta Uro-Quick contenente 2 ml di Mueller-Hinton brodo, successivamente sono stati addizionati 0.5 ml di sospensione del ceppo da saggiare (5x105 CFU/ml. Una cuvetta priva di farmaco è stata utilizzata come controllo. Dopo 3 o 5 ore di incubazione (per i ceppi Gram-negativi o Gram-positivi rispettivamente i risultati sono stati interpretati nel seguente modo: l’assenza di sviluppo indicava sensibilità, mentre una curva di crescita analoga a quella del controllo rappresentava un ceppo resistente. I microrganismi Gram-negativi sono stati saggiati con ciprofloxacina (CIP, ampicillina (AM, piperacillina (PIP, aztreonam (ATM, amoxicillina-clavulanato (AMC, piperacillina/tazobactam (TZP, imipenem (IPM, ceftazidime (CAZ, cefotaxime (CTX, cefepime (CFP, cefuroxime (CXM, ceftriaxone (CRO, amikacina (AN, gentamicina (GM e trimethoprim-sulfametossazolo (SXT. I Gram-positivi, invece, sono stati saggiati con ciprofloxacina (CIP, clindamicina (CM, eritromicina (E, rifampicina (RA, ampicillina (AM, penicillina (P, oxacillina (OXA, imipenem (IPM, gentamicina (GM, streptomicina (S, tetraciclina (TE, trimethoprim – sulfametazolo (SXT, vancomicina (VA e linezolid (LZD. Sono stati esaminati 197 ceppi Gram

  19. Cambios en el tono muscular en dos niños con parálisis cerebral espástica mediante la hipoterapia: reporte de casos

    OpenAIRE

    Rodríguez Laiseca, Yasmín Andrea; Lerma Castaño, Piedad Rocío

    2015-01-01

    Introducción: Estudios previos han demostrado que la hipoterapia como terapia complementaria mejora la función motora gruesa en niños con parálisis cerebral. Sin embargo la evidencia no es concluyente. Objetivo: Determinar los cambios en el tono muscular de dos pacientes con parálisis cerebral tipo cuadriparesia espástica mediante la hipoterapia. Descripción del caso: El estudio se llevó a cabo con dos sujetos de género masculino de dos años de edad, con diagnóstico de parálisis cerebral tipo...

  20. Evaluación de los niveles plasmáticos de hepcidina en pacientes con anemia ferropénica y cáncer colorectal

    OpenAIRE

    Vila Montañés, María

    2017-01-01

    RESUMEN TESIS DOCTORAL TITULO: “Evaluación de los niveles plasmáticos de hepcidina en pacientes con anemia ferropénica y cáncer colorectal.” AUTOR: María Vila Montañés INTRODUCCIÓN El objetivo general de este trabajo fue determinar los niveles plasmáticos de hepcidina y su posible relación con el tratamiento con hierro intravenoso. El hierro es una terapia clave en el manejo de la anemia preoperatoria en los pacientes con cáncer colorectal. La anemia preoperatoria es una en...

  1. Efectividad de la acupuntura con tachuela en afectados por epicondilitis

    Directory of Open Access Journals (Sweden)

    Mercedes Gay Muguercia

    2014-06-01

    Full Text Available Se realizó una intervención terapéutica en 20 pacientes con epicondilitis, remitidos de la consulta de Ortopedia al Departamento de Medicina Natural Tradicional del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, de septiembre a diciembre de 2012, con vistas a determinar la efectividad de la acupuntura con tachuela en ellos. Los afectados fueron valorados y, de forma aleatoria, se les distribuyó en 2 grupos de 10 integrantes cada uno: el de estudio, que recibió acupuntura (agujas de 0,2 mm de forma permanente en los puntos Ashi y en el IG-11, y el de control, tratado convencionalmente con antiinflamatorios y analgésicos. Luego de aplicadas las terapias, los pacientes fueron valorados a los 5, 10 y 15 días, teniendo en cuenta el cuadro clínico dado por dolor, inflamación e impotencia funcional. La regresión de los síntomas se evaluó por la escala visual analógica, y se obtuvo una efectividad marcada del tratamiento con acupuntura en relación con el medicamentoso

  2. Calidad de la dieta "antes y durante" un tratamiento de pérdida de peso basado en dieta mediterránea, terapia conductual y educación nutricional

    OpenAIRE

    Eva María Morales-Falo; Carmen Sánchez-Moreno; Alberto Esteban; Juan José Alburquerque; Marta Garaulet

    2013-01-01

    Introducción: El método de pérdida de peso (dieta mediterránea, terapia de comportamiento y educación nutricional) ha mostrado ser efectivo en el tratamiento de la obesidad. Objetivo: El objetivo del presente trabajo es evaluar y comparar la calidad de las dietas ingeridas antes y durante el tratamiento mediante el Índice de Alimentación Saludable (IAS) y su relación con diferentes variables. Materiales y métodos: La muestra fue de 392 pacientes (330 mujeres, 62 hombres), edad 39,3 ± 11,5 año...

  3. Avances en terapia insulínica en la diabetes mellitus tipo 1: Aciertos y desaciertos Advances in insulin-therapy in type 1 diabetes mellitus: Success and failures

    Directory of Open Access Journals (Sweden)

    Tania Mayvel Espinosa Reyes

    2007-04-01

    Full Text Available La historia del desarrollo del tratamiento farmacológico de la diabetes tuvo un capítulo esencial en el descubrimiento de la insulina y su introducción como t