WorldWideScience

Sample records for technology corporation ptc

  1. Agile machining and inspection thrust area team-on-machine probing / compatibility assessment of Parametric Technology Corporation (PTC) pro/CMM DMIS with Zeiss DMISEngine.

    Energy Technology Data Exchange (ETDEWEB)

    Wade, James Rokwel; Tomlinson, Kurt; Bryce, Edwin Anthony

    2008-09-01

    The charter goal of the Agile Machining and Inspection Thrust Area Team is to identify technical requirements, within the nuclear weapons complex (NWC), for Agile Machining and Inspection capabilities. During FY 2008, the team identified Parametric Technology Corporation (PTC) Pro/CMM as a software tool for use in off-line programming of probing routines--used for measurement--for machining and turning centers. The probing routine would be used for in-process verification of part geometry. The same Pro/CMM program used on the machine tool could also be employed for program validation / part verification using a coordinate measuring machine (CMM). Funding was provided to determine the compatibility of the Pro/CMM probing program with CMM software (Zeiss DMISEngine).

  2. PTC

    African Journals Online (AJOL)

    Ruqaiya Hussain

    2013-07-25

    Jul 25, 2013 ... of PTC taste sensitivity among some Muslim populations of North India, as till now no detailed information is available. .... provided the basis for a new, integrative investigation of PTC .... This trait is of genetic, epidemiologic and evolutionary interest .... ABO blood group, PTC taste ability, and red-green color.

  3. PTC

    African Journals Online (AJOL)

    Ruqaiya Hussain

    2013-07-25

    Jul 25, 2013 ... adopted as per the sorting technique of serial dilutions of. Harris and Kalmus [16] .... ABO blood group, PTC taste ability, and red-green color · blindness. Biol Bull .... related to coffee as a dietary source of niacin. Chem Senses.

  4. The New Heat Treatment Technology of A356 Aluminium Alloy Prepared by Ptc

    Science.gov (United States)

    Zhang, Lianyong; Jiang, Yanhua; Ma, Zhuang; Wang, Wenkui

    Phase Transition Cooling (PTC), using the absorbed latent heat during the melting of phase transition cooling medium to cool and solidify alloys in the process of casting, is a new casting technology. Specimens of A356 casting aluminum alloy were prepared by this method in the paper. The new heat treatment process (cast and then aging directly without solid solution) of A356 alloy was performed. For comparison, the conventional T6 heat treatment (solution and then aging treatment) was performed too. The mechanical properties of A356 alloy with different heat treatments were measured by tensile strength testing methods and microstructures of the alloy with different heat treatment process were investigated by optical microscopy (OM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-rays diffraction (XRD) and transmission electron microscopy (TEM) too. The results show that ultimate tensile strength (UTS) of A356 alloy with the new heat treatment process is much higher than that with conventional heat treatment while the elongations with the two heat treatment processes are very close. This is due to the grain refinement obtained after PTC processing.

  5. MINERGY CORPORATION GLASS FURNACE TECHNOLOGY EVALUATION: INNOVATION TECHNOLOGY EVALUATION REPORT

    Science.gov (United States)

    This report presents performance and economic data for a U.S. Environmental Protection Agency (EPA) Superfund Innovative Technology Evaluation (SITE) Program demonstration of the Minergy Corporation (Minergy) Glass Furnace Technology (GFT). The demonstration evaluated the techno...

  6. Designing Corporate Databases to Support Technology Innovation

    Science.gov (United States)

    Gultz, Michael Jarett

    2012-01-01

    Based on a review of the existing literature on database design, this study proposed a unified database model to support corporate technology innovation. This study assessed potential support for the model based on the opinions of 200 technology industry executives, including Chief Information Officers, Chief Knowledge Officers and Chief Learning…

  7. Emerging technologies and corporate culture at Microsoft: a methodological note.

    Science.gov (United States)

    Klein, David; Schmeling, James; Blanck, Peter

    2005-01-01

    This article explores factors important in the study and examination of corporate culture and change. The particular focus is on the technological methods used to conduct a study of accessible technology and corporate culture at Microsoft Corporation. Reasons for particular approaches are explained. Advantages and challenges of emerging technologies that store and retrieve information in the study of corporate culture are reviewed.

  8. 75 FR 39044 - Unisys Corporation, Technology Business Segment, Unisys Information Technology Division, Formerly...

    Science.gov (United States)

    2010-07-07

    ... Employment and Training Administration Unisys Corporation, Technology Business Segment, Unisys Information... of Unisys Corporation, Technology Business Segment, Unisys Information Technology Division, formerly..., Michigan location of Unisys Corporation, Technology Business Segment, Unisys Information...

  9. Corporate environmental management and information technology

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.

    2001-01-01

    for mapping information technology. Using this framework it focuses on the use of information technology in corporate environmental management, describes the market for standard environmental management information systems and implementation experiences from one large international company....... software, the Internet, computer networks, telecommunications devices, etc. Information technology also has an impact on how companies perform environmental management. This paper looks at the relations between corporate environmental management and information technology. First it presents a framework......Information technology has changed, is changing and will continue to change the face of business as we further enter the Information Society. Today it would be difficult for a company to function effectively without the aid of various information technologies such as accounting software, production...

  10. Corporate environmental management and information technology

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.

    2001-01-01

    for mapping information technology. Using this framework it focuses on the use of information technology in corporate environmental management, describes the market for standard environmental management information systems and implementation experiences from one large international company....... software, the Internet, computer networks, telecommunications devices, etc. Information technology also has an impact on how companies perform environmental management. This paper looks at the relations between corporate environmental management and information technology. First it presents a framework......Information technology has changed, is changing and will continue to change the face of business as we further enter the Information Society. Today it would be difficult for a company to function effectively without the aid of various information technologies such as accounting software, production...

  11. Corporate Environmental Management and Information Technology

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.

    2000-01-01

    Information technology has changed, is changing and will continue to change the face of business as we further enter the Information Society. Today it would be difficult for a company to function effectively without the aid of various information technologies such as accounting software, producti...... framework for the use of information technology in corporate environmental management (CEM), describes the market for standard environmental management information systems solutions, what main functionalities are available and what main trends are visible....

  12. Corporate Environmental Management and Information Technology

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.

    2000-01-01

    framework for the use of information technology in corporate environmental management (CEM), describes the market for standard environmental management information systems solutions, what main functionalities are available and what main trends are visible....... software, the internet, computer networks, telecommunications devices, etc. Information technology also has an impact on how companies perform environmental management. This paper explores the relations between environmental management and information technology in general terms. It offers a classification......Information technology has changed, is changing and will continue to change the face of business as we further enter the Information Society. Today it would be difficult for a company to function effectively without the aid of various information technologies such as accounting software, production...

  13. Voice input/output capabilities at Perception Technology Corporation

    Science.gov (United States)

    Ferber, Leon A.

    1977-01-01

    Condensed resumes of key company personnel at the Perception Technology Corporation are presented. The staff possesses recognition, speech synthesis, speaker authentication, and language identification. Hardware and software engineers' capabilities are included.

  14. 76 FR 5834 - International Business Machines Corporation, Global Technology Services Business Unit, Integrated...

    Science.gov (United States)

    2011-02-02

    ... Employment and Training Administration International Business Machines Corporation, Global Technology Services Business Unit, Integrated Technology Services, Cost and Expense Team, Payroll, Travel and Mobility... Business Machines Corporation, Global Technology Services Business Unit, Integrated Technology...

  15. 75 FR 20388 - International Business Machines Corporation, Global Technology Services Business Unit, Integrated...

    Science.gov (United States)

    2010-04-19

    ... Employment and Training Administration International Business Machines Corporation, Global Technology Services Business Unit, Integrated Technology Services, Cost and Expense Team, Working From Various States..., applicable to workers of International Business Machines Corporation, Global Technology Services...

  16. GENERAL ENVIRONMENTAL CORPORATION; CURE ELECTROCOAGULATION TECHNOLOGY: INNOVATIVE TECHNOLOGY EVALUATION REPORT

    Science.gov (United States)

    The CURE electrocoagulation technology was demonstrated under the Superfund Innovative Technology Evaluation (SITE) program at the U.S. Department of Energy (DOE) Rocky Flats Environmental Technology Site (RFETS), where water from the solar evaporation ponds (SEPs) was contaminat...

  17. The dual role of external corporate venturing in technological exploration

    DEFF Research Database (Denmark)

    Li, Ying; van de Vrande, Vareska; Vanhaverbeke, Wim

    2009-01-01

    ("exploration from partners" or "EFP"). There has been little insight on how external corporate venturing may affect the exploratory learning beyond the venturing partnerships ("exploration beyond partners" or "EBP"). We claim that prior venturing relations have a dual role: First, the innovation firm can learn...... from knowledge embedded in its partners. Second, it can also learn from through its partners about knowledge developed by other firms or organizations with whom the innovating firm had no external venturing relations before. In this paper, we are interested how external corporate venturing partnerships......Innovating firms can not only explore new technologies from its innovation partners, but also explore new technologies from the organizations to which the innovating firm has had no prior relationships. Prior studies have mostly focused on a firm's exploratory learning from its venturing partners...

  18. 78 FR 1265 - Dana Holding Corporation; Power Technologies Group Division; Including On-Site Leased Workers...

    Science.gov (United States)

    2013-01-08

    ... Employment and Training Administration Dana Holding Corporation; Power Technologies Group Division; Including... Technologies Group Division, Milwaukee, Wisconsin (subject firm). The worker group includes on-site leased... Company, Power Technologies Group Division, Milwaukee, Wisconsin, who were engaged in employment...

  19. 76 FR 66327 - Iron Mountain Information Management, Inc., Corporate Service Group, Information Technology (IT...

    Science.gov (United States)

    2011-10-26

    ..., Information Technology (IT) Division, Including On-Site Leased Workers From TEK Systems, Professional... Technology (IT) Division, including on-site leased workers from TEK Systems, Professional Alternative... Management, Inc., Corporate Service Group, Information Technology (IT) Division. The Department...

  20. The Importance of Localized Related Variety for International Diversification of Corporate Technology

    DEFF Research Database (Denmark)

    Dettmann, Eva; Lacasa, Iciar Dominguez; Günther, Jutta;

    2016-01-01

    The importance of localized related variety for international diversification of corporate technology, Regional Studies. Internationalization of research and development has increased substantially in recent years. This paper analyses the determinants of spatial distribution of foreign technologi......The importance of localized related variety for international diversification of corporate technology, Regional Studies. Internationalization of research and development has increased substantially in recent years. This paper analyses the determinants of spatial distribution of foreign...... technological activities. The estimations show that this is the case in regions characterized by a high overall technological strength. This suggests that related variety facilitates technological diversifications of foreign corporations in regions at the top of the geographic hierarchy...

  1. High-pressure xenon detector development at Constellation Technology Corporation

    Energy Technology Data Exchange (ETDEWEB)

    Austin, Robert A. [Constellation Technology Corporation, 7887 Bryan Dairy Road, Suite 100, Largo, FL 33777 (United States)], E-mail: austin@contech.com

    2007-08-21

    Xenon-filled ionization detectors, due to their high atomic number fill gas (Z=54), moderate densities ({approx}0.3-0.5 g/cm{sup 3}) and good energy resolution (2-4% at 662 keV), fill an important niche between more familiar technologies such as NaI(Tl) scintillators and germanium detectors. Until recently, difficulties with obtaining sufficient xenon purity, reducing microphonic sensitivity, and developing low-noise electronics compatible with small ionization signals have hampered the development of this nuclear detection field. Constellation Technology Corporation, whose experience with xenon detectors goes back to the mid 1990s, has made significant progress in these areas and has developed a commercial line of detectors with active volumes ranging from small (35 g Xe) to large (1400 g Xe). Current applications for Constellation's detectors are principally in the area of defense (Unmanned Aerial Vehicles and Advanced Spectroscopic Portals), but as awareness of this technology grows, it will surely find applications in a much expanded range of fields.

  2. High-pressure xenon detector development at Constellation Technology Corporation

    Science.gov (United States)

    Austin, Robert A.

    2007-08-01

    Xenon-filled ionization detectors, due to their high atomic number fill gas ( Z=54), moderate densities (˜0.3-0.5 g/cm 3) and good energy resolution (2-4% at 662 keV), fill an important niche between more familiar technologies such as NaI(Tl) scintillators and germanium detectors. Until recently, difficulties with obtaining sufficient xenon purity, reducing microphonic sensitivity, and developing low-noise electronics compatible with small ionization signals have hampered the development of this nuclear detection field. Constellation Technology Corporation, whose experience with xenon detectors goes back to the mid 1990s, has made significant progress in these areas and has developed a commercial line of detectors with active volumes ranging from small (35 g Xe) to large (1400 g Xe). Current applications for Constellation's detectors are principally in the area of defense (Unmanned Aerial Vehicles and Advanced Spectroscopic Portals), but as awareness of this technology grows, it will surely find applications in a much expanded range of fields.

  3. MAD-X PTC Integration

    CERN Document Server

    Schmidt, Frank; Goddard, B; Jacquet, D; Kain, V; Lamont, M; Mertens, V; Uythoven, J; Wenninger, J

    2005-01-01

    MAD-X is CERN's successor for MAD8, a program for accelerator design with a long history. MAD-X is a modular, better maintainable re-write of MAD8 with data structures written in `C'. Early on in the design of MAD-X we relied on the fact that older or doubtful modules could be replaced by new modules using the PTC code by E. Forest. Both codes remain independent entities but are linked via a converter to the MAD-X data structures. PTC is used for symplectic tracking of smaller machines and transfer line using better defined physical models of the elements and taking into account of how the elements are placed in the tunnel. The matching of the LHC will profit form the fact that the high order nonlinear parameters are provided by a PTC Normal Form analysis.

  4. 78 FR 52998 - Waiver to Space Exploration Technologies Corporation of Acceptable Risk Limit for Launch

    Science.gov (United States)

    2013-08-27

    ... TRANSPORTATION Federal Aviation Administration Waiver to Space Exploration Technologies Corporation of Acceptable...) by Space Exploration Technologies Corporation (SpaceX) to waive a limit that the risk to the public... questions concerning this waiver, contact Charles P. Brinkman, Licensing Program Lead, Commercial...

  5. 77 FR 51064 - Dana Holding Corporation, Power Technologies Group Division, Including On-Site Leased Workers...

    Science.gov (United States)

    2012-08-23

    ... Employment and Training Administration Dana Holding Corporation, Power Technologies Group Division, Including... Holding Corporation, Power Technologies Group Division, Milwaukee, Wisconsin (subject firm). The negative... competitive articles) in 2011 and 2012, loss of business with a firm that employed a worker group eligible...

  6. TECHNOLOGY EVALUATION REPORT: SILICATE TECHNOLOGY CORPORATION - SOLIDIFICATION/STABILIZATION OF PCP AND INORGANIC CONTAMINANTS IN SOILS - SELMA, CA

    Science.gov (United States)

    This Technolgy Evaluation Report evaluates the solidification/stabilization process of Silicate Technology Corporation (STC) for the on-site treatment of contaminated soil The STC immobilization technology uses a proprietary product (FMS Silicate) to chemically stabilize and ...

  7. The Importance of Localized Related Variety for International Diversification of Corporate Technology

    DEFF Research Database (Denmark)

    Dettmann, Eva; Lacasa, Iciar Dominguez; Günther, Jutta

    2016-01-01

    The importance of localized related variety for international diversification of corporate technology, Regional Studies. Internationalization of research and development has increased substantially in recent years. This paper analyses the determinants of spatial distribution of foreign technologi......The importance of localized related variety for international diversification of corporate technology, Regional Studies. Internationalization of research and development has increased substantially in recent years. This paper analyses the determinants of spatial distribution of foreign...... technological activities across 96 regions in Germany. It identifies foreign technological activities by applying the cross-border ownership concept to patent applications. The main proposition is that regions with higher related variety of technological activities between sectors attract more foreign...... technological activities. The estimations show that this is the case in regions characterized by a high overall technological strength. This suggests that related variety facilitates technological diversifications of foreign corporations in regions at the top of the geographic hierarchy...

  8. Design principles for corporate venture transition processes in established technology firms

    NARCIS (Netherlands)

    Burg, van J.C.; Jager, de S.; Reymen, I.M.M.J.; Cloodt, M.

    2012-01-01

    Corporate venturing has become a well known approach towards new business development and strategic renewal for established technology firms. However, without an effectively designed process for aligning and integrating a corporate venture in the established business, the firm increases the risk of

  9. 77 FR 74520 - Encore Clean Energy, Inc., Energy & Engine Technology Corp., Equity Media Holdings Corporation...

    Science.gov (United States)

    2012-12-14

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Encore Clean Energy, Inc., Energy & Engine Technology Corp., Equity Media Holdings Corporation, eTotalSource, Inc., Extensions, Inc., Firepond, Inc., and GNC Energy Corporation; Order Withdrawing...

  10. Design principles for corporate venture transition processes in established technology firms

    NARCIS (Netherlands)

    Burg, van J.C.; Jager, de S.; Reymen, I.M.M.J.; Cloodt, M.

    2012-01-01

    Corporate venturing has become a well known approach towards new business development and strategic renewal for established technology firms. However, without an effectively designed process for aligning and integrating a corporate venture in the established business, the firm increases the risk of

  11. Security Risks and Modern Cyber Security Technologies for Corporate Networks

    CERN Document Server

    Gharibi, Wajeb

    2011-01-01

    This article aims to highlight current trends on the market of corporate antivirus solutions. Brief overview of modern security threats that can destroy IT environment is provided as well as a typical structure and features of antivirus suits for corporate users presented on the market. The general requirements for corporate products are determined according to the last report from av-comparatives.org [1]. The detailed analysis of new features is provided based on an overview of products available on the market nowadays. At the end, an enumeration of modern trends in antivirus industry for corporate users completes this article. Finally, the main goal of this article is to stress an attention about new trends suggested by AV vendors in their solutions in order to protect customers against newest security threats.

  12. Research of corporate social responsibility in an energy efficient technologies development section

    Directory of Open Access Journals (Sweden)

    Lyashenko O.

    2013-06-01

    Full Text Available The article considered the concept of corporate social responsibility (CSR and its components. The Jevons paradox is examined, the mechanism of rebound effect on the example of energy efficient technologies is analyzed.

  13. Technological Innovation, Corporate R&D Alliances and Organizational Learning

    Science.gov (United States)

    1995-01-01

    transaction cost economics, a learning pe.rspective of innovation, corporate organizational learning strategies, including an integrated view of the research...CONSISTENT WITH TRANSACTION COSTS AND LEARNING THEORIES, AND TRANSNATIONAL GOVERNMENT POLICIES. Transaction Cost Theory Transaction costs theory originated...self-interest seeking with guile." (Williamson, 1975,9). As an explanation of why firms innovate and form alliances, transaction cost theory has

  14. 49 CFR 236.1031 - Previously approved PTC systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Previously approved PTC systems. 236.1031 Section... Train Control Systems § 236.1031 Previously approved PTC systems. (a) Any PTC system fully implemented and operational prior to March 16, 2010, may receive PTC System Certification if the applicable PTC...

  15. Partners in Technology: The University, the Public School, and the Corporation.

    Science.gov (United States)

    Leavy, Rebecca S.; Wallace, Mildred

    1995-01-01

    Discusses the need for technology instruction in teacher education programs and describes a partnership among Western Kentucky University, four corporations, and three school districts that provided a technology center for Western Kentucky's College of Education. Roles of the participants are explained and the impact of the Kentucky Education…

  16. The Impact of High School Principal's Technology Leadership on the Sustainability of Corporate Sponsored Information Communication Technology Curriculum

    Science.gov (United States)

    Gottwig, Bruce Ryan

    2013-01-01

    The proliferation of information communication technology (ICT) has placed educational institutions in the forefront in educating and training students as skilled consumers, engineers, and technicians of this widely used technology. Corporations that develop and use ICT are continually building a skilled workforce; however, because of the growth…

  17. PERCEPTION OF TASTE OF PHENYLTHIOUREA (PTC).

    Science.gov (United States)

    Examining 213 students of the first year at the faculty (3/4 women), 24.88% were found nontasting PTC . The differences between sexes are not...represented. With a quinine control test among nontasting, a small correlation to PTC was established. The results are in agreement with literature data. (Author)

  18. Phenylthiocarbamide (PTC) Tasting and Reported Depression.

    Science.gov (United States)

    Whittemore, Paul B.

    1986-01-01

    The phenylthiocarbamide (PTC) taste test was investigated for its potential as a genetically based biological marker for depression. Results indicated PTC tasters reported significantly higher levels of depression on the Beck Depression Inventory (BDI) than nontasters and they scored higher on 5 of the 21 items. (Author/BL)

  19. E-Mentoring: Technology, Trust, and Frequency in Corporate E-Mentoring Relationships

    Science.gov (United States)

    Godwin, Shannon G.

    2011-01-01

    Electronic mentoring through asynchronous methods using technologies such as e-mail or the Internet is used in the education industry whereby undergraduate and graduate students can be matched with either university professors or career professionals. However, corporate organizations with mentoring initiatives predominantly use traditional…

  20. 77 FR 13326 - Carpenter Technology Corporation and Latrobe Specialty Metals, Inc.; Analysis of Proposed...

    Science.gov (United States)

    2012-03-06

    ... Carpenter Technology Corporation and Latrobe Specialty Metals, Inc.; Analysis of Proposed Agreement... section below. Write ``Carpenter Latrobe, File No. 111 0207'' on your comment, and file your comment... receive it on or before March 29, 2012. Write ``Carpenter Latrobe, File No. 111 0207'' on your...

  1. 75 FR 65517 - Western Digital Technologies, Inc., Corporate Headquarters/Hard Drive Development Division, Lake...

    Science.gov (United States)

    2010-10-25

    ... Employment and Training Administration Western Digital Technologies, Inc., Corporate Headquarters/Hard Drive Development Division, Lake Forest, CA; Notice of Affirmative Determination Regarding Application for... determination was issued on August 5, 2010 and published in the Federal Register on August 23, 2010 (75 FR...

  2. 78 FR 43093 - Sensient Technologies Corporation; Withdrawal of Color Additive Petition

    Science.gov (United States)

    2013-07-19

    ... Technologies Corporation; Withdrawal of Color Additive Petition AGENCY: Food and Drug Administration, HHS... withdrawal, without prejudice to a future filing, of a color additive petition (CAP 8C0261) proposing that the color additive regulations be amended to provide for the safe use of External D&C Violet No. 2...

  3. Superconducting Technology Assessment (NSA, Office of Corporate Assessments)

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — The government, and particularly NSA, has a continuing need for ever-increasing computational power. The Agency is concerned about projected limitations of...

  4. PTC thermistor protects multiloaded power supplies

    Science.gov (United States)

    Leverone, H.; Mandell, N.

    1964-01-01

    A PTC /Positive-Temperature-Coefficient/ thermistor placed in series with each branch load of a multiload circuit prevents power loss in parallel branches. This thermistor may be used in any circuit requiring current limiting or intended overload resetting.

  5. Advances in MAD-X using PTC

    CERN Document Server

    Skowronski, P K; Forest, E

    2007-01-01

    For the last few years the MAD-X program makes use of the Polymorphic Tracking Code (PTC) to perform calculations related to beamdynamics in the nonlinear regime. An important new feature is the extension of the matching module to allow fitting of non-linear parameters to any order. Moreover, calculations can now be performed with parameter dependence defined in the MAD-X input. In addition, the user can access the PTC routines for the placement of a magnet with arbitrary position and orientation. This facilitates the design of non-standard lattices, in particular since a 3D visualization of a lattice is now available. For the LHC studies during commissioning it is of special interest that one has access to within the thick PTC elements which allows e.g. to find PTC Twiss parameters at any point in the ring.

  6. APPLICATION OF TECHNOLOGY BENCHMARKING (CORPORATE INTELLIGENCE IN THE MANAGEMENT OF ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Alexander L. Barannikov

    2014-01-01

    Full Text Available About technology benchmarking (corporate intelligence in the management of organization Benchmarking is an important part of the management of organization. It is aimed at study of the successful experience of various organizations and, first of all competitors, in order to improve on the basis of the information received by its own management and production of competitive products using a variety of sources. In the benchmarking directly use the instruments of corporate intelligence, which main purpose is information support of the activities of organizations.

  7. Ethnography of Corporeality: A Carnal Move in Educational Technology Research

    Science.gov (United States)

    Enriquez-Gibson, Judith

    2016-01-01

    Despite the increasing focus on non-dualistic and materialist approaches in education technology studies, the materiality of the body has not been adequately examined. Because of the heavy orientation towards affordance, interaction, participation, inclusion and access at the interface or between various spatial and liminal settings, the subject's…

  8. 49 CFR 236.1011 - PTC Implementation Plan content requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC Implementation Plan content requirements. 236... Positive Train Control Systems § 236.1011 PTC Implementation Plan content requirements. Link to an...) How the PTC railroad intends to comply with §§ 236.1009(c) and (d); (3) How the PTC system will...

  9. 2016 Wind Technologies Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-08-08

    Wind power capacity in the United States experienced strong growth in 2016. Recent and projected near-term growth is supported by the industry’s primary federal incentive—the production tax credit (PTC)—as well as a myriad of state-level policies. Wind additions have also been driven by improvements in the cost and performance of wind power technologies, yielding low power sales prices for utility, corporate, and other purchasers.

  10. Corporate governance and the adoption of health information technology within integrated delivery systems.

    Science.gov (United States)

    Baird, Aaron; Furukawa, Michael F; Rahman, Bushra; Schneller, Eugene S

    2014-01-01

    Although several previous studies have found "system affiliation" to be a significant and positive predictor of health information technology (IT) adoption, little is known about the association between corporate governance practices and adoption of IT within U.S. integrated delivery systems (IDSs). Rooted in agency theory and corporate governance research, this study examines the association between corporate governance practices (centralization of IT decision rights and strategic alignment between business and IT strategy) and IT adoption, standardization, and innovation within IDSs. Cross-sectional, retrospective analyses using data from the 2011 Health Information and Management Systems Society Analytics Database on adoption within IDSs (N = 485) is used to analyze the correlation between two corporate governance constructs (centralization of IT decision rights and strategic alignment) and three IT constructs (adoption, standardization, and innovation) for clinical and supply chain IT. Multivariate fractional logit, probit, and negative binomial regressions are applied. Multivariate regressions controlling for IDS and market characteristics find that measures of IT adoption, IT standardization, and innovative IT adoption are significantly associated with centralization of IT decision rights and strategic alignment. Specifically, centralization of IT decision rights is associated with 22% higher adoption of Bar Coding for Materials Management and 30%-35% fewer IT vendors for Clinical Data Repositories and Materials Management Information Systems. A combination of centralization and clinical IT strategic alignment is associated with 50% higher Computerized Physician Order Entry adoption, and centralization along with supply chain IT strategic alignment is significantly negatively correlated with Radio Frequency Identification adoption : Although IT adoption and standardization are likely to benefit from corporate governance practices within IDSs, innovation is

  11. Environmental impact assessment: chemical explosive fracturing project, Petroleum Technology Corporation, Leslie, Letcher and Perry counties, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Tonnessen, K.A.

    1977-05-19

    This review of the plans for a gas stimulation program by chemical explosive fracturing (CEF) in the Devonian shales of Letcher, Leslie and Perry counties, Kentucky also includes an assessment of the environmental consequences of the proposed project. This document was prepared at the request of the Nevada Operations Office of the Energy Research and Development Administration, and is intended to provide the information and data required for the preparation of an environmental assessment of the construction and testing program. This report was compiled from material provided by the Petroleum Technology Corporation of Redmond, Washington, Kentucky-West Virginia Gas Transmission Corporation of Prestonsburg, Kentucky and the State of Kentucky Bureau of Mines and Minerals during site visits in October, 1976.

  12. Pt/C Fuel Cell Catalyst Degradation

    DEFF Research Database (Denmark)

    Zana, Alessandro

    This thesis investigates the degradation behavior of Pt/C catalysts under simulated automotive conditions. By using the “tool box” synthesis method the Pt loading has been changed from low to high Pt loadings, therefore permitting to study the role of Pt on the degradation of high surface area (H...

  13. Pt/C Fuel Cell Catalyst Degradation

    DEFF Research Database (Denmark)

    Zana, Alessandro

    This thesis investigates the degradation behavior of Pt/C catalysts under simulated automotive conditions. By using the “tool box” synthesis method the Pt loading has been changed from low to high Pt loadings, therefore permitting to study the role of Pt on the degradation of high surface area (H...

  14. 49 CFR 236.1027 - PTC system exclusions.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC system exclusions. 236.1027 Section 236.1027... Systems § 236.1027 PTC system exclusions. (a) The requirements of this subpart apply to each office... PTC system. For purposes of this section, “office automation system” means any centralized or...

  15. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, C. LEE COOK DIVISION, DOVER CORPORATION, STATIC PAC (TM) SYSTEM, PHASE II REPORT

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Static Pac System, Phase II, natural gas reciprocating compressor rod packing manufactured by the C. Lee Cook Division, Dover Corporation. The Static Pac System is designed to seal th...

  16. Fitting mixture distributions to phenylthiocarbamide (PTC) sensitivity.

    OpenAIRE

    Jones, P N; G.J. McLachlan

    1991-01-01

    A technique for fitting mixture distributions to phenylthiocarbamide (PTC) sensitivity is described. Under the assumptions of Hardy-Weinberg equilibrium, a mixture of three normal components is postulated for the observed distribution, with the mixing parameters corresponding to the proportions of the three genotypes associated with two alleles A and a acting at a single locus. The corresponding genotypes AA, Aa, and aa are then considered to have separate means and variances. This paper is c...

  17. Information technology -- Telecommunications and information exchange between systems -- Corporate telecommunication networks -- Signalling interworking between QSIG and H.323 -- Generic functional protocol for the support of supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2001-01-01

    Information technology -- Telecommunications and information exchange between systems -- Corporate telecommunication networks -- Signalling interworking between QSIG and H.323 -- Generic functional protocol for the support of supplementary services

  18. Development of molten carbonate fuel cell technology at M-C Power Corporation

    Energy Technology Data Exchange (ETDEWEB)

    Dilger, D. [M-C Power Corp., Burr Ridge, IL (United States)

    1996-04-01

    M-C Power Corporation was founded in 1987 with the mission to further develop and subsequently commercialize molten carbonate fuel cells (MCFC). The technology chosen for commercialization was initially developed by the Institute of Gas technology (IGT). At the center of this MCFC technology is the Internally Manifolded Heat EXchange (IMHEX) separator plate design. The IMHEX technology design provides several functions within one component assembly. These functions include integrating the gas manifold structure into the fuel cell stack, separating the fuel gas stream from the oxidant gas stream, providing the required electrical contact between cells to achieve desired power output, and removing excess heat generated in the electrochemical process. Development of this MCFC technology from lab-scale sizes too a commercial area size of 1m{sup 2} has focused our efforts an demonstrating feasibility and evolutionary progress. The development effort will culminate in a proof-of-concept- 250kW power plant demonstration in 1996. The remainder of our commercialization program focuses upon lowering the costs associated with the MCFC power plant system in low production volumes.

  19. Applying Internet-based Technologies to Teaching Corporate Finance and Investments

    Directory of Open Access Journals (Sweden)

    Zhuoming “Joe” Peng

    2006-01-01

    Full Text Available Finance faculty are increasingly encouraged to use internet-based technologies in teaching. This paper examines students’ perceptions of finance faculty who use internet-based technologies and the impact on their learning experiences in undergraduate introductory corporate finance, investments, and MBA investments courses. The results suggest that offering all course materials online may enhance students’ learning experiences, however, the technologies may be best thought of as teaching tools. A better methodology for a finance course delivery may be that of in-classroom interactions between an instructor and the students while all the pertinent course materials are available online throughout the semester. There is a statistically significant difference between MBA (Master of Business Administration students and undergraduate business students in terms of their desire to use the internet for learning finance. Consistent with previous research, results indicate that it may not be common practice among faculty to use internet-based technologies, and that assistant professors tend to use technologies in teaching more often than their higher-ranked colleagues do.

  20. The Impact of High School Principal's Technology Leadership on the Sustainability of Corporate Sponsored Information Communication Technology Curriculum

    Science.gov (United States)

    Gottwig, Bruce Ryan

    2013-01-01

    The proliferation of information communication technology (ICT) has placed educational institutions in the forefront in educating and training students as skilled consumers, engineers, and technicians of this widely used technology. Corporations that develop and use ICT are continually building a skilled workforce; however, because of the growth…

  1. 49 CFR 236.1015 - PTC Safety Plan content requirements and PTC System Certification.

    Science.gov (United States)

    2010-10-01

    ... vendor or supplier to be addressed during the life-cycle of the PTC system, including maximum threshold...) A description of the safety assurance concepts that are to be used for system development, including... System Certification. 236.1015 Section 236.1015 Transportation Other Regulations Relating to...

  2. How Adults Learn from Self-Paced, Technology-Based Corporate Training: New Focus for Learners, New Focus for Designers

    Science.gov (United States)

    Dobrovolny, Jackie

    2006-01-01

    "How" do adults learn from self-paced, technology-based corporate training, which they select based on its relevance to their current employment responsibilities? Specifically, "how" do adults use the following learning strategies: prior experience, reflection, metacognition, conversations, generative learning strategies, and authentic…

  3. Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

    Science.gov (United States)

    Camp, Darius; Haitian He, Billy; Li, Sally; Althaus, Irene W; Holtz, Alexander M; Allen, Benjamin L; Charron, Frédéric; van Meyel, Donald J

    2014-10-01

    Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). Hh binding to Ptc is also proposed to sequester the ligand, limiting its spatial range of activity. In Drosophila, Interference hedgehog (Ihog) and Brother of ihog (Boi) are two conserved and redundant transmembrane proteins that are essential for Hh pathway activation. How Ihog and Boi activate signaling in response to Hh remains unknown; each can bind both Hh and Ptc and so it has been proposed that they are essential for both Hh reception and sequestration. Using genetic epistasis we established here that Ihog and Boi, and their orthologs in mice, act upstream or at the level of Ptc to allow Hh signal transduction. In the Drosophila developing wing model we found that it is through Hh pathway activation that Ihog and Boi maintain the boundary between the anterior and posterior compartments. We dissociated the contributions of Ptc from those of Ihog/Boi and, surprisingly, found that cells expressing Ptc can retain and sequester the Hh ligand without Ihog and Boi, but that Ihog and Boi cannot do so without Ptc. Together, these results reinforce the central role for Ptc in Hh binding in vivo and demonstrate that, although Ihog and Boi are dispensable for Hh sequestration, they are essential for pathway activation because they allow Hh to inhibit Ptc and thereby relieve its repression of Smo.

  4. Integrated assessment technology in management of competition efficiency in business corporations

    Directory of Open Access Journals (Sweden)

    Savel’eva Nadezhda

    2017-01-01

    Full Text Available To date, the banking sector is subsidized. the state co-finances players in the domestic banking sector against the background of reduced availability of foreign debt financing. on the one hand is an additional source of competitive advantages, on the other hand, the question is how commercial banks use their capabilities. In a fast growing sector of banking services, increased competition, rapid growth in the breadth and richness of banking service range it is necessary to use the entire arsenal of marketing tools that determine the competitiveness of services and effectiveness of company. The economic importance of technologies development for integrated assessment of competition efficiency is that banks have to be able to use different methods of competition for adaptation to ambient conditions changes and ensure competitive success. The article describes an integrated assessment approach to effectiveness of management of price and non-price competition in business corporations based on sample of banking market. The technology that proposed in article helps to identify the main target segments of consumers, investigate the influence and perception factors of price and non-price competition to the banking service consumers; to form the main ways and directions in management of competition efficiency; to evaluate the effectiveness of interventions.

  5. Threshold distributions of phenylthiocarbamide (PTC) in the Chinese population.

    Science.gov (United States)

    Guo, S W; Shen, F M; Wang, Y D; Zheng, C J

    1998-11-30

    The ability to taste phenylthiocarbamide (PTC) is a well-documented Mendelian trait. Mapping and cloning the gene(s) responsible for the PTC tasting ability would help to delineate the molecular basis for the variations in PTC tasting ability in humans and to shed new light on taste chemosensory functions. In view of the spectacular successes in genome science, the positional cloning strategy seems to be a feasible approach to the isolation of the gene(s) underlying the PTC tasting ability. As a first step toward mapping the gene(s), we collected PTC taste threshold data on 106 individuals, most of them being university students, in Shanghai, China. Using various parametric and nonparametric statistical methods, we have found that the data set is best described by a bimodal distribution. The frequency of PTC nontasters is estimated to be 10%. This is consistent with the view that the PTC nontasting ability follows a recessive mode of inheritance. Several authors had previously reported PTC data on Chinese living outside China. Our data are, to our knowledge, the first ever collected from the Chinese population within China.

  6. Integration of market pull and technology push in the corporate front end and innovation management - Insights from the German software industry

    DEFF Research Database (Denmark)

    Brem, Alexander; Voigt, K.-I.

    2009-01-01

    will be introduced as to how market pull and technology push activities within the corporate technology and innovation management can be integrated. Hence, the purpose of the paper is to introduce a theory-based conceptual framework that can be used in today’s corporate environment. In this context, technology......Within the framework of this paper, an extensive literature overview of technology and innovation management aspects on market pull and technology push will be given. The existing classification of market pull and technology push will be particularly shown and called into question by suggesting...

  7. Information-communication technologies in formation of corporate culture of higher school

    Directory of Open Access Journals (Sweden)

    Алла Борисовна Денисова

    2012-06-01

    Full Text Available The corporate culture of high school possesses a powerful educational potential and it is a condition of formation of readiness and successful adaptation of the graduating student in his life after studies to environment. The corporate culture is formed by means of all forms of student's activity, but is the most effective in nonlearning sphere. To be modern and actual, the nonlearning activity, directed on formation of the corporate competence of students, demands making a system of technical and informational support.

  8. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma.

    Science.gov (United States)

    Henderson, Ying C; Shellenberger, Thomas D; Williams, Michelle D; El-Naggar, Adel K; Fredrick, Mitchell J; Cieply, Kathleen M; Clayman, Gary L

    2009-01-15

    Papillary thyroid carcinoma (PTC), the most common thyroid malignancy, usually possesses BRAF mutation or rearranged in translation (RET)/PTC rearrangements. PTC usually possesses BRAF mutation or RET/PTC rearrangements. The mutation status of patients with recurrent PTC has never been characterized in a large population. Mutation status was determined in a cohort of 54 patients with recurrent PTC and analyzed for clinicopathologic relationships. BRAF and ras mutations were determined by PCR and sequencing of genomic DNA. RET/PTC rearrangements were analyzed by reverse transcription-PCR. BRAF mutation in exon 15 (V600E) was found in 42/54 (77.8%) recurrent PTC patients. The RET/PTC rearrangements were detected in 9 of 54 (16.7%) patients. In addition, 5 of 54 (9.3%) recurrent PTC patients had both a BRAF mutation and a RET/PTC rearrangement. The prevalence of tumors with dual mutations found in the recurrent population far exceeds the frequency historically reported for patients with primary PTC. Patients with dual mutations were significantly older (80% older than 45 years) than patients with a BRAF mutation alone (38% older than 45 years). Recurrent PTC is significantly associated with a predominant BRAF mutation. RET/PTC rearrangements, although commonly associated with primary PTCs in younger patients, are uncommonly found in recurrent PTC patients. In addition, the incidence of dual mutations was higher in patients with recurrent PTC than in those primary PTC, as reported by others.

  9. Overexpression of wild-type c-RET and zero prevalence of RET/PTC rearrangements are associated with papillary thyroid cancer (PTC) in Kuwait.

    Science.gov (United States)

    El-Abdallah, Abir A; Junaid, Thamradeen A

    2011-02-01

    Papillary thyroid carcinoma (PTC) is common in Kuwait. The activation of the RET oncogene by DNA rearrangement (RET/PTC) is known to have an important role in PTC carcinogenesis. However, the real frequency of the RET/PTC expression in PTC is variable between different studies. This study seeks to determine the prevalence of RET/PTC and to analyze the RET oncogene expression associated with PTC in Kuwait. RET expression and DNA rearrangements (RET/PTC 1, RET/PTC 2 and RET/PTC 3) were studied by RT-PCR in different thyroid diseases. Results were confirmed by the Southern blot and by immunohistochemistry. Quantitative real-time PCR was used to determine the level of RET mRNA expression in PTCs. Wild-type (nonrearranged) c-RET oncogene was overexpressed in 60% of PTC cases and absent in follicular thyroid carcinoma (FTC), anaplastic thyroid carcinoma (ATC), follicular adenomas (FA) or normal thyroid. No RET/PTC rearrangement was detected in any sample. The c-RET expression in Hashimoto's thyroiditis and multinodular goiter was limited to follicular cells with PTC-like nuclear changes. The overexpression of wild-type c-RET is a characteristic molecular event of PTCs in Kuwait. The prevalence of RET/PTC is zero and among the lowest recorded in the world. Copyright © 2010 Elsevier Inc. All rights reserved.

  10. Synthesis and Reactions of Five-Membered Heterocycles Using Phase Transfer Catalyst (PTC Techniques

    Directory of Open Access Journals (Sweden)

    Ahmed M. El-Sayed

    2014-01-01

    Full Text Available Phase transfer catalysts (PTCs have been widely used for the synthesis of organic compounds particularly in both liquid-liquid and solid-liquid heterogeneous reaction mixtures. They are known to accelerate reaction rates by facilitating formation of interphase transfer of species and making reactions between reagents in two immiscible phases possible. Application of PTC instead of traditional technologies for industrial processes of organic synthesis provides substantial benefits for the environment. On the basis of numerous reports it is evident that phase-transfer catalysis is the most efficient way for generation and reactions of many active intermediates. In this review we report various uses of PTC in syntheses and reactions of five-membered heterocycles compounds and their multifused rings.

  11. The rise of the prosumer: an analysis of self-service technology adoption in a corporate context

    Directory of Open Access Journals (Sweden)

    Eoghan National University of Ireland

    2017-01-01

    Full Text Available The adoption of self-service technology (SST has been well researched in consumer contexts but, despite the existing body of work, few studies have investigated in detail the specific determinants for user satisfaction in a corporate context. This study attempts to address this deficit. The goal of our work is to examine employees’ perception of SST. To do this, four dimensions of the SSTQUAL quality scale namely (a functionality; (b security; (c design and (d customization were adapted to collect data from 182 knowledge workers in a financial services multi-national organization. The findings lead to the following insights. First respondents believe that SSTs can perform the task required in a timely and straightforward manner. They also feel that transactions are safe and secure. However, we learned that, although essential to user satisfaction, respondents have concerns regarding the design and customization of the technology. They believe that the technology employed is not user centric. Furthermore, respondents are not pleased with the layouts or aesthetics of the technology and they feel that the features are not personalized for their specific requirements. The study is important for many reasons. First, it expands the discussion on SST adoption by focusing on the corporate context thus contributing to the body of knowledge in the domain. Second, it captures and analyses real world empirical data and helps bridge the gap between theory and practice. Finally, the findings can help service providers to create effective user driven solutions.

  12. Corporate Venturing

    DEFF Research Database (Denmark)

    Vintergaard, Christian

    From the perspective of Austrian economics, this paper develops a conceptual understanding ofhow corporate venture managers recognize and discover opportunities in a network environment.In an effort to create a better understanding of who is involved in process, this paper reports onthe development...... path of an entrepreneurial opportunity of the Danish corporate venture capitalist,Danfoss A/S. This paper distinguishes itself from previous research done on entrepreneurialopportunities by creating a holistic and conceptual framework, which broadens and expands theperception of the market participants...... involved in recognition and discovery. Consequently thepaper offers insight to a diversified group of actors who mix and match technological and marketcapabilities in a constant process of recognition and discovery.Key words: Corporate venturing, entrepreneurship, discovery, networks, opportunities,recognition....

  13. Molecular characteristics of papillary thyroid carcinomas without BRAF mutation or RET/PTC rearrangement: relationship with clinico-pathological features.

    Science.gov (United States)

    Durand, Stéphanie; Ferraro-Peyret, Carole; Joufre, Mireille; Chave, Annie; Borson-Chazot, Françoise; Selmi-Ruby, Samia; Rousset, Bernard

    2009-06-01

    About 60-70% of papillary thyroid carcinomas (PTC) present a BRAF(T1799A) gene mutation or a rearrangement of RET gene (RET/PTC). In this study, we examined whether PTC without BRAF(T1799A) mutation and without RET/PTC rearrangement named PTC-ga(-) were distinguishable from PTC-ga(+) (with one or the other gene alteration) on the basis of gene expression characteristics. We analyzed the mutational state of 116 PTC and we compared gene expression profiles of PTC-ga(+) and PTC-ga(-) from data of a 200 gene macroarray and quantitative PCR. Seventy five PTC were PTC-ga(+) and 41 were PTC-ga(-). Unsupervised analyses of macroarray data by hierarchical clustering led to a complete segregation of PTC-ga(+) and PTC-ga(-). In a series of 42 genes previously recognized as PTC 'marker' genes, 22 were found to be expressed at a comparable level in PTC-ga(-) and normal tissue. Thyroid-specific genes, TPO, TG, DIO1, and DIO2 were under-expressed in PTC-ga(+) but expressed at a normal level in PTC-ga(-). A few genes including DUOX1 and DUOX2 were selectively dys-regulated in PTC-ga(-). Tumor grade of PTC-ga(-) was lower than that of PTC-ga(+). There was a strong association between the mutational state and histiotype of PTC; 81% of PTC follicular variants were corresponded to PTC-ga(-), whereas 84% of PTC of classical form were PTC-ga(+). In conclusion, we show that PTC without BRAF(T1799A) mutation or RET/PTC rearrangement, mainly corresponding to follicular variants, maintain a thyroid differentiation expression level close to that of normal tissue and should be of better prognosis than PTC with one or the other gene alteration.

  14. Corporate Responsibility

    DEFF Research Database (Denmark)

    Waddock, Sandra; Rasche, Andreas

    2015-01-01

    We define and discuss the concept of corporate responsibility. We suggest that corporate responsibility has some unique characteristics, which makes it different from earlier conceptions of corporate social responsibility. Our discussion further shows commonalities and differences between corporate...... responsibility and related concepts, such as corporate citizenship and business ethics. We also outline some ways in which corporations have implemented corporate responsibility in practice....

  15. Assessment of RET/PTC1 and RET/PTC3 rearrangements in fine-needle aspiration biopsy specimens collected from patients with Hashimoto's thyroiditis

    Directory of Open Access Journals (Sweden)

    Cyniak-Magierska Anna

    2011-01-01

    Full Text Available Abstract Background RET/PTC rearrangements are the most frequent molecular changes in papillary thyroid carcinoma (PTC. So far, 15 main RET/PTC rearrangements have been described, among which RET/PTC1 and RET/PTC3 are the most common in PTC - especially in radiation-induced tumours. RET/PTC1 and RET/PTC3 are the result of intrachromosomal paracentric inversions in chromosome 10, where RET and the activating genes (H4 and ELE1, respectively are located. Recently, RET/PTC rearrangements have been shown not only in PTC but also in benign thyroid lesions, including Hashimoto's thyroiditis (HT. The aim of study was an assessment of RET/PTC1 and RET/PTC3 rearrangements in patients with Hashimoto's thyroiditis. Materials and methods Thyroid aspirates, eligible for the study, were obtained from 26 patients with Hashimoto's thyroiditis by fine-needle aspiration biopsy (FNAB. Each aspirate was smeared for conventional cytology, while its remaining part was immediately washed out of the needle. The cells, obtained from the needle, were used in further investigation. Total RNA from FNAB was extracted by use of an RNeasy Micro Kit, based on modified Chomczynski and Sacchi's method and reverse transcription (RT-PCR was done. Quantitative evaluation of RET/PTC1 and RET/PTC3 rearrangements by real-time PCR was performed by an ABI PRISM® 7500 Sequence Detection System. In the study, PTC tissues with known RET/PTC1 and RET/PTC3 rearrangements served as a reference standard (calibrator, while β-actin gene was used as endogenous control. Results Amplification reactions were done in triplicate for each examined sample. No RET/PTC1 and RET/PTC3 rearrangements were found in the examined samples. Conclusions Our results indicate that RET/PTC1 and RET/PTC3 rearrangements in Hashimoto's thyroiditis, if any, are rather rare events and further investigations should be conducted in order to determine molecular changes, connecting Hashimoto's thyroiditis with PTC.

  16. Case Studies of Reading in a High Technology Corporation. Reading Competencies and Practices. Technical Report #2.

    Science.gov (United States)

    Kirsch, Irwin; Guthrie, John

    Individuals in 14 job categories at the Analytical Instrument Division of the Hewlett-Packard Corporation were observed and interviewed for six months to determine their reading practices at work and in leisure settings. The individuals ranged from a research chemist and a printed circuit designer, to a quality assurance inspector and a mechanical…

  17. A Framework to Support Global Corporate M-Learning: Learner Initiative and Technology Acceptance across Cultures

    Science.gov (United States)

    Farrell, Wendy

    2015-01-01

    Corporations are growing more and more international and accordingly need to train and develop an increasingly diverse and dispersed employee based. M-learning seems like it may be the solution if it can cross cultures. Learner initiative has been shown to be a disadvantage of distant learning environments, which would include m-learning.…

  18. DETERMINANTS OF THE CHOICE OF MARKETING CHANNELS BY CORPORATE CLIENTS: AN ANALYSIS OF THE INFORMATION TECHNOLOGY SECTOR

    Directory of Open Access Journals (Sweden)

    Guilherme Soares

    2012-12-01

    Full Text Available Based on a survey of 505 corporate clients from the information technology industry, this study uses a logit statistical model to analyze whether such factors as loyalty, trust, client importance, intimacy between customer and supplier and the cost of changing suppliers may affect the choice of the marketing channel used by the client. The results show that the greater intimacy between a supplier and a corporate client is a determining factor for the client’s preference for being served by the manufacturer rather than an intermediary. In contrast, clients’ perception of their own importance to the supplier is not very relevant to their preference for being served directly by the manufacturer, and the other factors were not identified as (statistically important determinants of the choice of the marketing channel. These results suggest that the real advantage of the direct sales channel over the indirect sales channel lies in its ability to strengthen the client-manufacturer relationship, thereby contributing to the development of solutions that better serve the needs of corporate clients.

  19. Navigating the management of follicular variant papillary thyroid carcinoma subtypes: a classic PTC comparison.

    Science.gov (United States)

    Finnerty, Brendan M; Kleiman, David A; Scognamiglio, Theresa; Aronova, Anna; Beninato, Toni; Fahey, Thomas J; Zarnegar, Rasa

    2015-04-01

    There are three subtypes of follicular variant papillary thyroid carcinoma (fvPTC): completely encapsulated, well circumscribed, and infiltrative. While infiltrative tumors are more aggressive than completely encapsulated, controversy exists regarding management of fvPTC subtypes. We compared the clinicopathologic features of fvPTC subtypes to those of classic PTC (cPTC) to help guide fvPTC management, using cPTC as a reference. A retrospective review was performed on 316 patients with PTC treated at a single institution from 2004 to 2011. There were 197 cPTC and 119 fvPTC tumors, including completely encapsulated (n = 46), well circumscribed (n = 46), and infiltrative (n = 27). Clinicopathologic data were compared between groups. fvPTC patients had larger tumors than cPTC patients (1.6 cm vs. 1.2 cm, p = 0.001), but age, sex, and family history did not differ. Thirty-one percent of cPTC tumors had extrathyroidal extension compared to 0 % of completely encapsulated, 0 % of well-circumscribed, and 52 % of infiltrative fvPTC tumors (p management algorithm for fvPTC.

  20. Going Corporate

    CERN Document Server

    Kadre, Shailendra

    2011-01-01

    Going Corporate: A Geek's Guide shows technology workers how to gain the understanding and skills necessary for becoming an effective, promotable manager or sought-after consultant or freelancer. Technology professionals typically dive deeply into small pieces of technology - like lines of code or the design of a circuit. As a result, they may have trouble seeing the bigger picture and how their work supports an organization's goals. But ignoring or dismissing the business or operational aspects of projects and products can lead to career stagnation. In fact, understanding the larger business

  1. Analysis of economic indicators for GPS technologies application in Agricultural Corporation Belgrade (PKB)

    OpenAIRE

    Marković, Dragan; Krstić, Dragan; Simonović, Vojislav; Marković, Ivana

    2012-01-01

    This paper examined the level of savings in the application of modern technical systems for satellite guidance and control over performing agricultural operations throughout the season. The exemplary property was Agricultural Corporation Belgrade (PKB), which covers about 21.000 hectares of arable land. The effects of plot shape and direction of movement of tractor-attachment units in calculating the savings from reduced overlapping of adjacent passes were studied. The analysis was carried ou...

  2. ENVIRONMENTAL TECHNOLOGY VERIFICATION: TEST REPORT OF CONTROL OF BIOAEROSOLS IN HLVAC SYSTEMS: AEOLUS CORPORATION SYNTHETIC MINIPLEAT V-CELL, SMV-M13-2424

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Synthetic Minipleat V-Cell, SMV-M13-2424 air filter for dust and bioaerosol filtration manufactured by Aeolus Corporation. The pressure drop across the filter was 77 Pa clean and 348 ...

  3. ENVIRONMENTAL TECHNOLOGY VERIFICATION: TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS: AEOLUS CORPORATION SYNTHETIC MINIPLEAT V-CELL, SMV-M14-2424

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Synthetic Minipleat V-Cell, SMV-M14-2424 air filter for dust and bioaerosol filtration manufactured by Aeolus Corporation. The pressure drop across the filter was 104 Pa clean and 348...

  4. Application of Derrick Corporation's stack sizer technology for slimes reduction in 6 inch clean coal hydrocyclone circuits

    Energy Technology Data Exchange (ETDEWEB)

    Brodzik, P.

    2009-04-15

    The article discusses the successful introduction of Derrick Corporation's Stack Sizer technology for removing minus 200 mesh slimes from 6-inch coal hydrocyclone underflow prior to froth flotation or dewatering by screen bowl centrifuges. In 2006, the James River Coal Company selected the Stack Sizer fitted with Derrick 150 micron and 100 micron urethane screen panels for removal of the minus 100 mesh high ash clay fraction from the clean coal spiral product circuits. After this application proved successful, Derrick Corporation introduced new 75 micron urethane screen panels for use on the Stack Sizer. Evaluation of feed slurry to flotation cells and screen bowl centrifuges showed significant amounts of minus 75 micron that could potentially be removed by efficient screening technology. Removal of the minus 75 micron fraction was sought to reduce ash and moisture content of the final clean coal product. Full-scale lab tests confirmed that the Stack Sizer fitted with Derrick 75 micron urethane screen panels consistently reduced the minus 75 micron percentage in coal slurry from 6-inch clean coal hydrocyclone underflow that is approximately 15 to 20% solid by-weight and 30 to 60% minus 75 micron to a clean coal fraction that is approximately 13 to 16% minus 75 micron. As a result total ash is reduced from approximately 36 to 38% in the hydrocyclone underflow to 14 to 16% in the oversize product fraction form the Stack Sizers. 1 fig., 2 tabs., 5 photos.

  5. MAD-X/PTC lattice design for DAPHNE at Frascati

    CERN Document Server

    Forest, Etienne; Schmidt, Frank

    2006-01-01

    In absence of a program that takes as an input the desired or known location of the magnets in the tunnel, accelerator designers have been using MAD that looks at a ring as a sequence of magnets without a connection to the tunnel. In many simple examples that is just fine, but once more complicated structures are treated one is bound to play tricks with MAD. Here PTC comes to the rescue. It is shown how pieces of this machine that exist in MADX format are used in PTC to create this double ring, as found on the accelerator floor, with a proper survey in the forward and backward direction. Special elements have been implemented in MAD-X to allow the full PTC description of the machine.

  6. Application of New Electrolyte Model to Phase Transfer Catalyst (PTC) Systems

    DEFF Research Database (Denmark)

    2015-01-01

    Abstract Phase transfer catalyst (PTC) is used to transfer the desirable active form of an anion from the aqueous phase to organic phase where the reaction occurs. One of major challenges for process design of the PTC system is to establish a reliable thermodynamic model capable of describing phase...... in PTC systems, thereby, extending the application range of the PTC-system model. The solubility of PTC in organic solvents, which is a key factor for strategy of PTC and solvent selection, has been calculated using the e-NRTL-SAC model....

  7. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, ANEST IWATA CORPORATION W400-LV SPRAY GUN

    Science.gov (United States)

    Under EPA’s Environmental Technology Verification program, which provides objective and scientific third party analysis of new technology that can benefit the environment, the pollution prevention capabilities of a high transfer efficiency liquid spray gun was tested. This ...

  8. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, ANEST IWATA CORPORATION W400-LV SPRAY GUN

    Science.gov (United States)

    Under EPA’s Environmental Technology Verification program, which provides objective and scientific third party analysis of new technology that can benefit the environment, the pollution prevention capabilities of a high transfer efficiency liquid spray gun was tested. This ...

  9. 78 FR 23472 - Amendments to Existing Validated End-User Authorizations: CSMC Technologies Corporation in the...

    Science.gov (United States)

    2013-04-19

    ... include commodities, software, and technology, except those controlled for missile technology or crime... information against the VEU authorization criteria. Given the nature of the review, and in light of...

  10. [RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma].

    Science.gov (United States)

    Zhang, X; Su, X; Chen, W C; Li, Y; Yang, Z Y; Deng, W Z; Deng, T C; Yang, A K

    2017-06-07

    Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Clinicopathological parameters, lifestyle, and thyroid hormone levels were collected. RET/PTC rearrangements were detected by TaqMan PCR and verified by Sanger sequencing.Data were analyzed with SPSS software, including chi-square test, Fisher's exact test, Mann-Whitney U test, Student's t-test, and Logistic regression. Results:RET/PTC rearrangements were not found in all paracancerous normal thyroid tissues, and were detected in 23.68% (27/114) of PTC. Further analysis revealed no correlation between RET/PTC rearrangement and thyroid function, clinicopathologic parameters, and lifestyle in the total PTC group or in the subgroup of patients with concomitant diseases (including Hashimoto's thyroiditis and nodular goiter). But in the subgroup of PTC without concomitant disease, RET/PTC rearrangement was associated with tumor multifocal (P=0.018), and RET/PTC-positive PTC patients had an increased risk of tumor multifocal (OR=5.57, 95% CI 1.39-22.33). It was also found that RET/PTC rearrangement was associated with an abnormal increase in TSH level of one month after surgery (P= 0.037). Conclusion: Nodular goiter and Hashimoto 's thyroiditis may be a confounding factor in PTC. RET/PTC rearrangement may play an important role in the occurrence of thyroid carcinoma multifocal after exclusion of this confounding factor.

  11. Teaching the Business of Instructional Technology: A Collaborative Corporate/Academic Partnership.

    Science.gov (United States)

    Kapp, Karl M.; Phillips, Timothy L.

    2003-01-01

    Describes a program developed at Bloomsburg University (Pennsylvania) to prepare graduate students to be technologically savvy and to teach them the business aspects of instructional technology and electronic learning. Discusses partnerships with instructional technology professionals; collaborative student projects; a request for proposal…

  12. Next Slide Please: The Magical, Scientific and Corporate Discourses of Visual Projection Technologies

    Science.gov (United States)

    Eisenhauer, Jennifer F.

    2006-01-01

    This article examines the cultural history of slide projection technologies by focusing upon how such technologies acquire cultural meaning. The meanings acquired by these technologies emerge in areas as diverse as public and domestic entertainment, religion, science, and education. I identify three important discursive shifts impacting the…

  13. Environmental management maturity of local and multinational high-technology corporations located in Brazil: the role of business internationalization in pollution prevention

    Directory of Open Access Journals (Sweden)

    Giovanna Maialle

    2016-06-01

    Full Text Available Abstract This paper identifies and characterizes the environmental maturity level of local and multinational high-technology corporations located in Brazil. This characterization is achieved by discussing the adoption of environmental management practices and considering aspects of the productive process stage. An eight-case study was conducted through data triangulation using interviews with employees in diverse organizational areas, direct observations and secondary data. The results indicate the differences in environmental positioning among the studied corporations with a predominance of preventive practices, i.e., an emphasis on eco-efficiency and compliance with legislation. It was also noted that environmental concerns in the corporations are related to internationalization and, in some cases, to the pressure exerted by corporations that represent the brand of the products produced in Brazil. Moreover, the adoption of environmental practices based on the productive process stage supported the environmental maturity classifications of the studied companies.

  14. OUTSOURCING AS AN EFFICIENT TECHNOLOGY FOR CONSOLIDATION OF CAPITAL PARTNERS OF THE CORPORATION

    Directory of Open Access Journals (Sweden)

    Yermolenko V. V.

    2015-04-01

    Full Text Available The article examines the traditional concept of outsourcing from the perspective of the characteristics of a public Corporation of the knowledge economy and building competitiveness. The author notes essential narrow interpretation of traditional outsourcing and examines a new, broader understanding of how the mobilization of intellectual and human capital, third party outsourcers for the benefit of the Corporation. Formation of the sector of the knowledge economy in Russia actualizes the importance of joint and coordinated problem solving connections intellectual, human and other intangible capital partners, who are provided with a number of activities as part of the mega business process associated with the production of intellectual goods and services. According to the authors, the development of outsourcing leads to a network form of business organization and mega business process is transformed into a network conglomerate, the capital of which is "adapting" to each other with the formation of a harmonious configuration of material and immaterial capital. Such configuration of capital we call capitulorum, as a new instrument for the realization of development strategy

  15. SYNTHESIS OF ACRYLIC ESTERS IN PTC: KINETICS AND ECOLOGICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    G.Torosyan

    2013-06-01

    Full Text Available The synthesis of esters of acrylic acids, which are applied for synthesis of polymeric materials by phase transfer catalysis were discussed (PTC, which is very useful for reduction of reaction consumption of materials and power.This method has substantial advantages including high speed of the process, soft condition of reaction and reduced pollution.

  16. SMOKING INCLINED GROUPS ACCORDING TO THE PHENOTYPE OF THE PTC GENE.

    Science.gov (United States)

    Khukhunaishvili, R; Tskvitinidze, S; Koridze, M; Nagervadze, M; Chelidze, N

    2016-09-01

    The ability to sense phenylthiocarbamide (PTC) bitterness represents a well-known and convenient genetic marker for human populations and biomedical studies. Two basic phenotypes can be dichotomized by PTC sensitivity: PTC-sensitive or "tester" and PTC-insensitive or "non-tester". The majority of the population (approximately 70%) belong to the PTC-sensitive phenotype, while the remaining 30% are PTC-insensitive. The distribution of PTC sensitivities varies by consumption of alcohol, bitter coffee and cigarettes. This study was conducted among randomly selected 90 cigarette smokers living in the Ajara Region of Georgia. Our results indicate that PTC-insensitive phenotypes are correlated with cigarette consumption and should be considered as an important genetic proxy for cigarette use. This marker may prove very useful for identifying adolescents who might benefit from a focused smoking prevention intervention.

  17. The integration of corporate social responsibility into the strategy of technology-intensive firms: a case study

    Directory of Open Access Journals (Sweden)

    Miha Škerlavaj

    2010-06-01

    Full Text Available This paper presents a new perspective which calls for an integration of ethics and corporate social responsibility (CSR into the company strategy as a source of competitive advantages. The research question we pose is how a company can successfully carry out this integration of CSR into its strategic management, for which a model that includes three stages – introduction, implementation and generalization of CSR – is presented. Based on an exploratory case study within a Spanish technology-intensive firm (Indra, we show the way this company has developed and implemented an explicit plan for the integration of ethical values and CSR initiatives into its corporate and business strategies. Although this company has established its own methodology in order to develop and implement CSR plans, it fits in essence to our three-stage model of CSR integration. In general, our analyses show a beneficial impact of the development and implementation of CSR plan for this technology-intensive company. In particular, it seems that the CSR plan enables companies to improve its’ internal and external (competitive context through a better exploration and exploitation of knowledge, its stable relationships with stakeholders and the development and improvement of intangible resources such as reputation or social capital. It is also shown that there are important factors to consider in order this process can successfully carried out, such as organizational culture, human resource practices or knowledge management systems. Future research will need to engage in largerscale confirmatory as well as longitudinal studies of the impact of CSR implementation for company performance.

  18. Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.

    Science.gov (United States)

    Unger, K; Malisch, E; Thomas, G; Braselmann, H; Walch, A; Jackl, G; Lewis, P; Lengfelder, E; Bogdanova, T; Wienberg, J; Zitzelsberger, H

    2008-07-31

    The aim of this study is to investigate additional genetic alterations in papillary thyroid carcinomas (PTCs) with known RET/PTC rearrangements. We applied array-based comparative genomic hybridization (array CGH) to 33 PTC (20 PTC from adults, 13 post-Chernobyl PTC from children) with known RET/PTC status. Principal component analysis and hierarchical cluster analysis identified cases with similar aberration patterns. Significant deviations between tumour-groups were obtained by statistical testing (Fisher's exact test in combination with Benjamini-Hochberg FDR-controlling procedure). FISH analysis on FFPE sections was applied to validate the array CGH data. Deletions were found more frequently in RET/PTC-positive and RET/PTC-negative tumours than amplifications. Specific aberration signatures were identified that discriminated between RET/PTC-positive and RET/PTC-negative cases (aberrations on chromosomes 1p, 3q, 4p, 7p, 9p/q, 10q, 12q, 13q and 21q). In addition, childhood and adult RET/PTC-positive cases differ significantly for a deletion on the distal part of chromosome 1p. There are additional alterations in RET/PTC-positive tumours, which may act as modifiers of RET activation. In contrast, alterations in RET/PTC-negative tumours indicate alternative routes of tumour development. The data presented serve as a starting point for further studies on gene expression and function of genes identified in this study.

  19. Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model.

    Science.gov (United States)

    Moosajee, Mariya; Tracey-White, Dhani; Smart, Matthew; Weetall, Marla; Torriano, Simona; Kalatzis, Vasiliki; da Cruz, Lyndon; Coffey, Peter; Webster, Andrew R; Welch, Ellen

    2016-08-15

    Choroideremia (CHM) is an X-linked chorioretinal dystrophy that is caused by mutations within a single gene, CHM Currently no effective treatment exists for these patients. Since over 30% of patients harbour nonsense mutations in CHM, nonsense suppression therapy using translational readthrough inducing drugs may provide functional rescue of REP1, thus attenuating progressive sight loss. Here, we employed two CHM model systems to systematically test the efficacy and safety of ataluren (PTC124) and its novel analog PTC-414: (1) the chm(ru848) zebrafish, the only nonsense mutation animal model of CHM harbouring a TAA nonsense mutation, and (2) a primary human fibroblast cell line from a CHM patient harbouring a TAG nonsense mutation. PTC124 or PTC-414 treatment of chm(ru848) embryos led to a ∼2.0-fold increase in survival, prevented the onset of retinal degeneration with reduced oxidative stress and apoptosis, increased rep1 protein by 23.1% (PTC124) and 17.2% (PTC-414) and restored biochemical function as confirmed through in vitro prenylation assays (98 ± 2% [PTC124] and 68 ± 5% [PTC-414]). In CHM(Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC124 (42 ± 5%) or PTC-414 (36 ± 11%), although an increase in REP1 protein was not detected in these cells, in contrast to the zebrafish model. This comprehensive study on the use of PTC124 and PTC-414 as successful nonsense suppression agents for the treatment of CHM highlights the translational potential of these drugs for inherited retinal disease. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  20. Towards a Guideline for Design of a Corporate Entrepreneurship Function for Business Development in Medium-Sized Technology-Based Companies

    NARCIS (Netherlands)

    Uittenbogaard, Boaz; Broens, Lute; Groen, Aard J.

    2005-01-01

    The speed with which global high-technology markets evolve makes companies recognize that an effective innovation process is the best way to guarantee competitiveness. However, when (medium-sized) companies then wish to set up a corporate entrepreneurship function to enhance business development pro

  1. H.E. Professor Wang Liheng, Minister of Aviation of the People's Republic of China, President, China Aerospace Science & Technology Corporation

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    H. E. Professor Wang Liheng, Minister of Aviation, and President, China Aerospace Science & Technology Corporation, People's Republic of China (2nd from left) with (from left to right) Professor Hans Hofer, Professor Roger Cashmore, Research Director for Collider Programmes, Professor Samuel C. C. Ting, CERN and Professor Lei Gang, Secretary to the Minister, September 2001.

  2. Corporate Entrepreneurship

    DEFF Research Database (Denmark)

    Lassen, Astrid Heidemann

    2006-01-01

    The recognition of the importance of entrepreneurial dynamics in corporate context is increasingly acknowledged in both entrepreneurship and strategic management literature, as firms today face a reality in which frame-breaking innovation is an important element of survival. From this understanding......, the concept of Strategic Entrepreneurship (SE) has arisen, arguing a logic of focusing on the intersections between the two fields. This paper sets out to explore the SE construct empirically. Through seven case studies evolving around radical technological innovations, evidence is found of the importance...

  3. Visualization technology in neuropsychological research: A case study on corporal imaginary

    Directory of Open Access Journals (Sweden)

    Heidi Figueroa Sarriera

    2013-11-01

    Full Text Available Psychology, as a discipline, adopts a dualistic imaginary of the body: as a porous yet closed boundary. Therefore, accessing the "truth" of the subject requires all sorts of techniques and tools. The psychological discourse often considers these devices in exteriority of the subject. As a counterpoint, I propose that the artifacts are a constituent part of the corporal imaginary. The argument compares the Skinner Air Crib and Gesell’s Laboratory, two inventions of the mid-twentieth century, and a XXI century neuropsychological research about the location of the self. In the first two cases, the body is constructed as a porous barrier that participates within hygienic parameters, both operating and optimizing individual performance and military metaphors that has shaped social policy practices. The discussion of the neuropsychological research, as a case study, does not intend to question the results of the research from the neuropsychological field. It points towards those understandings and assumptions that reveal the connection of the neuropsychological discourse with its cultural context. Special attention is paid to gender construction, ways of mediating scientific knowledge, the hybridity between the neuropsychological reductionism of the scientific framing and the entertainment industry; as well as to the new forms of identity formation and the complementarity of the visuals and performance in the contemporary scene. 

  4. Corporate Branding and Corporate Reputation

    DEFF Research Database (Denmark)

    Karmark, Esben

    2013-01-01

    Corporate branding has been seen as developing in “waves”. This chapter explores the links between corporate branding and corporate reputation as they emerge in the context of three waves of corporate branding. It highlights the way in which the two constructs have related to each other through o...... for corporate brands and corporate communication.......Corporate branding has been seen as developing in “waves”. This chapter explores the links between corporate branding and corporate reputation as they emerge in the context of three waves of corporate branding. It highlights the way in which the two constructs have related to each other through...... organizational culture and identity, and how, although characterized by parallel developments, new ideas and models from a “third” wave of corporate branding challenge prevailing assumptions of corporate reputation particularly in terms of the assumptions that reputations emerge from authentic and transparent...

  5. RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Romei, Cristina; Elisei, Rossella

    2012-01-01

    Thyroid carcinoma is the most frequent endocrine cancer accounting for 5-10% of thyroid nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all thyroid carcinoma. Although much is known about its epidemiology, pathogenesis, clinical, and biological behavior, the only documented risk factor for PTC is the ionizing radiation exposure. Rearrangements of the Rearranged during Transfection (RET) proto-oncogene are found in PTC and have been shown to play a pathogenic role. The first RET rearrangement, named RET/PTC, was discovered in 1987. This rearrangement constitutively activates the transcription of the RET tyrosine-kinase domain in follicular cell, thus triggering the signaling along the MAPK pathway and an uncontrolled proliferation. Up to now, 13 different types of RET/PTC rearrangements have been reported but the two most common are RET/PTC1 and RET/PTC3. Ionizing radiations are responsible for the generation of RET/PTC rearrangements, as supported by in vitro studies and by the evidence that RET/PTC, and particularly RET/PTC3, are highly prevalent in radiation induced PTC. However, many thyroid tumors without any history of radiation exposure harbor similar RET rearrangements. The overall prevalence of RET/PTC rearrangements varies from 20 to 70% of PTCs and they are more frequent in childhood than in adulthood thyroid cancer. Controversial data have been reported on the relationship between RET/PTC rearrangements and the PTC prognosis. RET/PTC3 is usually associated with a more aggressive phenotype and in particular with a greater tumor size, the solid variant, and a more advanced stage at diagnosis which are all poor prognostic factors. In contrast, RET/PTC1 rearrangement does not correlate with any clinical-pathological characteristics of PTC. Moreover, the RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the

  6. PHENYLTHIOCARBAMIDE (PTC) TASTER STATUS IN SOUTH INDIAN ADULT MEDICAL STUDENTS

    OpenAIRE

    Sachin Rathod; Pallavi Jawale; Suresh Babu Kondaveeti; Chitra Pillai

    2016-01-01

    BACKGROUND The objective of this study was to determine Phenylthiocarbamide (PTC) taster status in adults who are studying medicine and its relationship with anthropometric variables such as Body Mass Index (BMI), Body Fat Percentage (BFP) and pleasantness of sugar, salt, and fat. A total of 112 subjects rated the intensity of Phenylthiocarbamide and sodium chloride (NaCl) solutions using the labelled magnitude scale. For pleasantness evaluation, it was used with concentrated l...

  7. ENVIORNMENTAL TECHNOLOGY VERIFICATION REPORT: ANEST IWATA CORPORATION LPH400-LV HVLP SPRAY GUN

    Science.gov (United States)

    This Enviornmental Technology Verification reports on the characteristics of a paint spray gun. The research showed that the spray gun provided absolute and relative increases in transfer efficiency over the base line and provided a reduction in the use of paint.

  8. ENVIORNMENTAL TECHNOLOGY VERIFICATION REPORT: ANEST IWATA CORPORATION LPH400-LV HVLP SPRAY GUN

    Science.gov (United States)

    This Enviornmental Technology Verification reports on the characteristics of a paint spray gun. The research showed that the spray gun provided absolute and relative increases in transfer efficiency over the base line and provided a reduction in the use of paint.

  9. Mathematics for the Workplace. Applications from Machine Tool Technology (Michelin Tire Corporation). A Teacher's Guide.

    Science.gov (United States)

    Wallace, Johnny M.; Stewart, Grover

    This module presents a real-world context in which mathematics skills (geometry and trigonometry) are used as part of a daily routine. The context is the machine tool technology field, and the module aims to help students develop the ability to analyze diagrams in order to make mathematical computations. The modules, which features applications…

  10. The corporate shaping of GM crops as a technology for the poor

    NARCIS (Netherlands)

    Glover, D.

    2010-01-01

    Genetically modified (GM, transgenic) crops are often invoked in debates about poverty, hunger, and agricultural development. The framing of GM crops as a 'pro-poor' and environmentally sustainable technology was partly a creation of the biotechnology industry, but cannot be explained as merely a cy

  11. The corporate shaping of GM crops as a technology for the poor

    NARCIS (Netherlands)

    Glover, D.

    2010-01-01

    Genetically modified (GM, transgenic) crops are often invoked in debates about poverty, hunger, and agricultural development. The framing of GM crops as a 'pro-poor' and environmentally sustainable technology was partly a creation of the biotechnology industry, but cannot be explained as merely a

  12. PTC-6 vacuum system: WallWalker{trademark} and Blastrac{reg_sign} shot blast cleaning system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The LTC Americas, Inc. wall decontamination technology consisted of two pneumatic hand-held tools: (1) a roto-peen scaler that used star cutters and (2) a 3-piston hammer with reciprocating bits. The hand-held tools were used in conjunction with the LTC PTC-6 vacuum system which captured dust and debris as the wall decontamination took place. Recommendations for improved worker safety and health during use of the PTC-6 vacuum system with hand-held tools include: (1) keeping all hoses and lines as orderly as possible in compliance with good housekeeping requirements; (2) ergonomic training to include techniques in lifting, bending, stooping, twisting, etc.; (3) use of a clamping system to hold hoses to the vacuum system; (4) a safety line on the air line connections; (5) use of a mechanical lifting system for waste drum removal; and (6) the use of ergonomically designed tools.

  13. 31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

    CERN Multimedia

    Raphaël Piguet

    2011-01-01

    31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

  14. Corporate Law and Corporate Governance

    OpenAIRE

    Roberta Romano

    1998-01-01

    We have seen a revival in interest in corporate law and corporate governance since the 1980s, as researchers applied the tools of the new institutional economics and modern corporate finance to analyze the new transactions emerging in the 1980s takeover wave. This article focuses on three mechanisms of corporate governance to illustrate the analytical usefulness of transaction cost economics for corporate law. They are the board of directors; relational investing, a form of block ownership in...

  15. [Oncogenes RET/PTC and mechanisms of their involvement in thyroid cancerogenesis].

    Science.gov (United States)

    Voskoboĭnyk, L H

    2009-01-01

    Papillary thyroid carcinomas are the most common type of thyroid oncopathology, and are rather often associated with the expression of RET/PTC oncogens. The first oncogen RET/PTC1 was isolated more than 20 years ago. Now 13 different forms of RET/PTC are known, and 12 different partner-genes are described, that could be involved in formation of RET/PTC oncogenes. The most common of them are RET/PTC1 and RET/PTC3 forms. The great majority of oncogens RET/PTC, except for two--ELKS-RET and HOOK3-RET, have been founded in radioaction-induced thyroid tumors. There is an opinion that the key role in development of papillary thyroid carcinomas belongs to RET/PTC oncogens. The data about different types of RET/PTC oncogens, factors, that lead to their formation have been described in the present review. Also different mechanisms of activation of transduction pathways and gene's expression in thyroid cells after RET/PTC induction have been presented.

  16. Antecedents of Behavioral Intention to Use Mobile Telecommunication Services: Effects of Corporate Social Responsibility and Technology Acceptance

    Directory of Open Access Journals (Sweden)

    Sanghoon Lee

    2015-08-01

    Full Text Available The concepts of corporate social responsibility (CSR and user experience have been identified as core determinants of the success of service providers. Accordingly, practitioners and researchers have investigated the effects of service providers’ CSR and user experience on behavioral intention to use a particular service. Based on the importance of these concepts, the current study integrates subjective dimensions of CSR with the technology acceptance model (TAM to explore whether the CSR efforts of mobile telecommunication services providers and the service acceptance of their customers have significant effects on behavioral intention to use a service. We apply structural equation modeling and find that two factors from the TAM (i.e., usefulness and ease of use as well as economic, social, and environmental responsibility are significantly related to customer attitude and satisfaction. Moreover, our results show that there are significantly positive relationships between customer attitude and behavioral intention to use a service, as well as between customer satisfaction and intention. Practical and theoretical implications along with notable limitations of the current study are presented.

  17. Evaluation of the Acceptance of Audience Response System by Corporations Using the Technology Acceptance Model

    Science.gov (United States)

    Chu, Hsing-Hui; Lu, Ta-Jung; Wann, Jong-Wen

    The purpose of this research is to explore enterprises' acceptance of Audience Response System (ARS) using Technology Acceptance Model (TAM). The findings show that (1) IT characteristics and facilitating conditions could be external variables of TAM. (2) The degree of E-business has positive significant correlation with behavioral intention of employees. (3) TAM is a good model to predict and explain IT acceptance. (4) Demographic variables, industry and firm characteristics have no significant correlation with ARS acceptance. The results provide useful information to managers and ARS providers that (1) ARS providers should focus more on creating different usages to enhance interactivity and employees' using intention. (2) Managers should pay attention to build sound internal facilitating conditions for introducing IT. (3) According to the degree of E-business, managers should set up strategic stages of introducing IT. (4) Providers should increase product promotion and also leverage academic and government to promote ARS.

  18. Strategies for Corporate Global Expansion of Pakistani Companies in the Age of Technology

    Directory of Open Access Journals (Sweden)

    Jawaid Ahmed Qureshi

    2015-04-01

    Full Text Available This study intends to meticulously probe about the applications of cutting-edge strategies of globally expanding companies operative in several industrial sectors of Pakistan. Many companies craft and execute various strategies to globalize their operations and networks in several continents, which can not only benefit them but add value in the domestic cum global economy. Many researchers expounded that along with many other factors, capacity-building and competitive edges of business provide these companies the competitive strengths to excel in their global operations. Regarding such strengths, advancement in technology inclusive of research in business R&D (Research & Development, and marketing and business research, process design, automation, and e-commerce play a decisive role in providing them the core competitive edges that they leverage to advance their growth and expansion in the global market. This paper employs hybrid research techniques including qualitative and quantitative research. Semi-structured interviews have been taken for qualitative enquiry and structured survey has been undertaken for quantitative enquiry. The samples are drawn from multiple populations pertaining top-five export sectors of Pakistan by applying convenience sampling procedures for interviews and proportionate stratified sampling articulated with systematic sampling for survey. The findings uncover that after turning as retrenched domestic entities, many of the companies in Pakistan prefer global expansion. They usually resume from export operations in various countries especially where they develop a network of business associates, and then gradually move to open subsidiaries abroad. They avail technological edges to upgrade their processes, plants, products

  19. The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.

    Science.gov (United States)

    Rusciano, Maria Rosaria; Salzano, Marcella; Monaco, Sara; Sapio, Maria Rosaria; Illario, Maddalena; De Falco, Valentina; Santoro, Massimo; Campiglia, Pietro; Pastore, Lucio; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario

    2010-03-01

    RET/papillary thyroid carcinoma (PTC), TRK-T, or activating mutations of Ras and BRaf are frequent genetic alterations in PTC, all leading to the activation of the extracellular-regulated kinase (Erk) cascade. The aim of this study was to investigate the role of calmodulin-dependent kinase II (CaMKII) in the signal transduction leading to Erk activation in PTC cells. In normal thyroid cells, CaMKII and Erk were in the inactive form in the absence of stimulation. In primary PTC cultures and in PTC cell lines harboring the oncogenes RET/PTC-1 or BRaf(V600E), CaMKII was active also in the absence of any stimulation. Inhibition of calmodulin or phospholipase C (PLC) attenuated the level of CaMKII activation. Expression of recombinant RET/PTC-3, BRaf(V600E), or Ras(V12) induced CaMKII activation. Inhibition of CaMKII attenuated Erk activation and DNA synthesis in thyroid papillary carcinoma (TPC-1), a cell line harboring RET/PTC-1, suggesting that CaMKII is a component of the Erk signal cascade in this cell line. In conclusion, PTCs contain an active PLC/Ca(2+)/calmodulin-dependent signal inducing constitutive activation of CaMKII. This kinase is activated by BRaf(V600E), oncogenic Ras, and by RET/PTC. CaMKII participates to the activation of the Erk pathway by oncogenic Ras and RET/PTC and contributes to their signal output, thus modulating tumor cell proliferation.

  20. Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC-like nuclear alterations in Hashimoto's thyroiditis.

    Science.gov (United States)

    Zhang, K E; Ge, Shu-Jian; Lin, Xiao-Yan; Lv, Bei-Bei; Cao, Zhi-Xin; Li, Jia-Mei; Xu, Jia-Wen; Wang, Qiang-Xiu

    2016-03-01

    Intercellular adhesion molecule 1 (ICAM-1) is important in the progression of inflammatory responses. Recently, increased levels of ICAM-1 have been reported in a number of types of malignancy. The present study aimed to investigate ICAM-1 expression in papillary thyroid cancer (PTC) and in Hashimoto's thyroiditis (HT) with PTC-like nuclear alterations, and to assess the predictive value of ICAM-1 in thyroid lesions. ICAM-1 expression was retrospectively investigated in 132 consecutive cases of PTC, 72 cases of HT, 10 of follicular cancer, 15 of follicular adenoma, 16 of nodular goiter and 8 samples of normal thyroid tissue using immunohistochemical analyses, and in 42 PTC patients using western blotting. ICAM-1 expression was not detected in normal follicular cells, follicular lesions (adenoma and cancer) and benign nodular hyperplasia, but was frequently overexpressed in PTC cells. ICAM-1 overexpression was associated with extra-thyroidal invasion and lymph node metastasis; no association was found with age, gender, tumor size, multifocality, pathological stage, recurrence or distant metastasis. ICAM-1 expression in HT patients with PTC-like nuclear alterations was significantly higher than that in HT cases with non-PTC-like features. Compared with antibodies against cytokeratin 19, galectin-3 and Hector Battifora mesothelial-1, ICAM-1 was the most sensitive marker for the detection of PTC-like features in HT. These findings demonstrate that ICAM-1 expression is upregulated in PTC and in HT with PTC-like nuclear alterations. This feature may be an important factor in the progression of cancer of the thyroid gland.

  1. The mechanism of technological diversification promoting corporate performance%技术多元化促进企业绩效的机理研究

    Institute of Scientific and Technical Information of China (English)

    何郁冰

    2011-01-01

    技术多元化影响着企业产品创新战略的选择与绩效,但是既有文献并未对技术多元化影响企业绩效的机制进行研究,也较缺乏基于中国企业的实证分析.基于最新理论研究并结合实地调研结果,本研究从产品创新战略角度探讨了技术多元化对企业绩效的中介机制问题.研究结果发现,产品创新战略在技术多元化影响企业经营绩效过程中起完全中介作用,在技术多元化影响企业创新绩效过程中起部分中介作用.%Technological diversification has a impact on the choice of company' s product innovation strategy and its performance, however the existing literatures have not analyzed on how the mechanism of technological diversification impacts corporate performance; in the meantime, the relative empirical analysis based on Chinese companies are also lack.Based on the latest theoretical research and the results of on site research, the mediative mechanism betwee corporate technological diversification and its performance is studied from a angle of product innovation strategy.The empirical results suggest that poruct innovation strategy has completely played a mediative role in the impact of corporate technological diversification on its business performance, but only has played a partially mediative role in the impact of corporate technological diversification on its innovation performance.

  2. 2014 Wind Technologies Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Daghouth, Naim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hoen, Ben [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mills, Andrew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hamachi LaCommare, Kristina [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Millstein, Dev [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hansen, Dana [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Porter, Kevin [Exeter Associates, Columbia, MD (United States); Widiss, Rebecca [Exeter Associates, Columbia, MD (United States); Buckley, Michael [Exeter Associates, Columbia, MD (United States); Oteri, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United States); Smith, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tegen, Suzanne [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-08-06

    Wind power capacity additions in the United States rebounded in 2014, and continued growth through 2016 is anticipated. Recent and projected near-term growth is supported by the industry’s primary federal incentive—the production tax credit (PTC)—which is available for projects that began construction by the end of 2014. Wind additions are also being driven by recent improvements in the cost and performance of wind power technologies, which have resulted in the lowest power sales prices ever seen in the U.S. wind sector. Growing corporate demand for wind energy and state-level policies play important roles as well. Expectations for continued technological advancements and cost reductions may further boost future growth. At the same time, the prospects for growth beyond 2016 are uncertain. The PTC has expired, and its renewal remains in question. Continued low natural gas prices, modest electricity demand growth, and limited near-term demand from state renewables portfolio standards (RPS) have also put a damper on growth expectations. These trends, in combination with increasingly global supply chains, have limited the growth of domestic manufacturing of wind equipment. What they mean for wind power additions through the end of the decade and beyond will be dictated in part by future natural gas prices, fossil plant retirements, and policy decisions.

  3. Corporate Awakening

    DEFF Research Database (Denmark)

    LaFrance, Julie; Lehmann, Martin

    2005-01-01

    Predominantly since the 1992 Rio Summit, corporations have been increasingly pursuing partnerships with public institutions including governments, international organisations and NGOs that aim to contribute to sustainable development activities. Partnerships have become more common as corporation...... public-private partnerships. These theoretical perspectives are used to gain a deeper understanding of the corporate drivers that motivated TOTAL S.A. to approach UNESCO for cooperation on community development programs in Myanmar.......Predominantly since the 1992 Rio Summit, corporations have been increasingly pursuing partnerships with public institutions including governments, international organisations and NGOs that aim to contribute to sustainable development activities. Partnerships have become more common as corporations...... react to mounting pressure from corporate stakeholders, civil society and government on the responsible nature of their business practices. The corporate awakening towards a broader role of business in society and the trend of corporations embracing partnerships has led many to question the driving...

  4. Rand Corporation

    Science.gov (United States)

    ... Toggle Search Site-wide Search Search RAND RAND Corporation Provides Objective Research Services and Public Policy Analysis ... on Twitter Share on LinkedIn About The RAND Corporation is a research organization that develops solutions to ...

  5. Corporate Schooling Meets Corporate Media: Standards, Testing, and Technophilia

    Science.gov (United States)

    Saltman, Kenneth J.

    2016-01-01

    Educational publishing corporations and media corporations in the United States have been converging, especially through the promotion of standardization, testing, and for-profit educational technologies. Media and technology companies--including News Corp, Apple, and Microsoft--have significantly expanded their presence in public schools to sell…

  6. Concomitant RAS, RET/PTC, or BRAF mutations in advanced stage of papillary thyroid carcinoma.

    Science.gov (United States)

    Zou, Minjing; Baitei, Essa Y; Alzahrani, Ali S; BinHumaid, Faisal S; Alkhafaji, Dania; Al-Rijjal, Roua A; Meyer, Brian F; Shi, Yufei

    2014-08-01

    RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We sought to examine the prognostic value of concomitant mutations in PTC. We investigated 88 PTC for concomitant mutations. Mutation in BRAF exon 15, KRAS, NRAS, and HRAS were studied by polymerase chain reaction (PCR)-sequencing of tumor DNA; RET/PTC rearrangement was determined by reverse transcription (RT)-PCR-sequencing of tumor cDNA. BRAF(V600E) was detected in 39 of 82 classic PTC (CPTC) and in all three tall-cell variants (49%, 42/85). KRAS mutation (p.Q61R and p.S65N) was detected in two CPTC (2%, 2/88) and NRAS(Q61R) in one CPTC and two follicular variant PTC (FVPTC; 3%, 3/88). KRAS(S65N) was identified for the first time in thyroid cancer and could activate mitogen-associated protein kinase (MAPK). RET/PTC-1 was detected in nine CPTC, one tall-cell variant, and two FVPTC. Concomitant BRAF(V600E) and KRAS, or BRAF(V600E) and RET/PTC-1 mutations were found in two CPTC, and six CPTC and one tall-cell variant, respectively. In total, 11 concomitant mutations were found in 88 PTC samples (13%), and most of them were in the advanced stage of disease (8/11, 73%; pPTC and are associated with poor prognosis. The concomitant mutations may represent intratumor heterogeneity and could exert a gene dosage effect to promote disease progression. KRAS(S65N) can constitutively activate the MAPK pathway.

  7. Corporate Governance

    OpenAIRE

    International Finance Corporation; UN Global Compact

    2017-01-01

    Corporate citizenship - a commitment to ethical behavior in business strategy, operations, and culture - has been on the periphery of corporate governance and board leadership, linked mainly to corporate reputation. However, in today’s globalized and interconnected world, investors, creditors, and other stakeholders have come to recognize that environmental, social, and governance responsi...

  8. PENGENDALIAN MESIN HOIST HANGER DALAM PROSES PTC/ED MENGGUNAKAN PLC OMRON

    Directory of Open Access Journals (Sweden)

    Wahyudi Wahyudi

    2012-02-01

    Full Text Available The development of technology demands efficient and work speed, so it needs a system which can handleseveral things.This problem can be covered with PLC (Programmable Logic Control that can integrateseveral self standing component to be an integrated control system and can be changed the configurationwithout change all instrument. Modify the ladder program can alter system of PLC. This paper showsHoist Hanger system in PTC/ED (Pre Treatment Chemical/Electrocoat Dispotition process that controlledby PLC. Above input from limit switch, sensor, or the other input, PLC system drives the motorrelay Hoist Hanger machine. That cause the motor relay Hoist Hanger change its condition, so the movingof Hoist Hanger machine will be suitable with PLC program.

  9. Regulation of Protein Kinase B Tyrosine Phosphorylation by Thyroid-Specific Oncogenic RET/PTC Kinases

    National Research Council Canada - National Science Library

    Jung, Hye Sook; Kim, Dong Wook; Jo, Young Suk; Chung, Hyo Kyun; Song, Jung Hun; Park, Jong Sun; Park, Ki Cheol; Park, Su Hyeon; Hwang, Jung Hwan; Jo, Ki-Won; Shong, Minho

    2005-01-01

    Papillary thyroid carcinoma (PTC) is a heterogenous disorder characterized by unique gene rearrangements and gene mutations that activate signaling pathways responsible for cellular transformation, survival, and antiapoptosis...

  10. PTC MathCAD and Workgroup Manager: Implementation in a Multi-Org System

    Science.gov (United States)

    Jones, Corey

    2015-01-01

    In this presentation, the presenter will review what was done at Kennedy Space Center to deploy and implement PTC MathCAD and PTC Workgroup Manager in a multi-org system. During the presentation the presenter will explain how they configured PTC Windchill to create custom soft-types and object initialization rules for their custom numbering scheme and why they choose these methods. This presentation will also include how to modify the EPM default soft-type file in the PTC Windchill server codebase folder. The presenter will also go over the code used in a start up script to initiate PTC MathCAD and PTC Workgroup Manager in the proper order, and also set up the environment variables when running both PTC Workgroup Manager and PTC Creo. The configuration.ini file the presenter used will also be reviewed to show you how to set up the PTC Workgroup Manager and customized it to their user community. This presentation will be of interest to administrators trying to create a similar set-up in either a single org or multiple org system deployment. The big take away will be ideas and best practices learned through implementing this system, and the lessons learned what to do and not to do when setting up this configuration. Attendees will be exposed to several different sets of code used and that worked well and will hear some limitations on what the software can accomplish when configured this way.

  11. Preparation of Polyacrylate-based Conductive Coatings and Its PTC Effect

    Institute of Scientific and Technical Information of China (English)

    XIONG Chuan-xi; HU Hui-rong; ZHOU Zhi-yong; ZHANG Yi; DONG Li-jie

    2004-01-01

    Polyacrylate- based conductive coatings were prepared from polyacrylate emulsion as matrix andcarbon black (CB) whose surface was treated with titanate coupling agent as conducting particles. One kind oforganic crystal was added to study its effects on the electrical conductivity and PTC ( positive temperature coeffi-cient ) effect of the conductive coatings. Experimental results show that the coatings containing only polyacrylateemulsion and CB exhibit an excellent electrical conductivity but bad PTC effect, and when organic crystal is added,PTC effect is characterized and can increase by 2 orders of magtitude. The critical transformation temperature ofpolyacrylate emulsion/CB PTC composites is decided by melting point of organic crystals.

  12. Corporate attributes and corporate accruals

    National Research Council Canada - National Science Library

    Md Shamimul Hasan; Normah Omar; Rashidah Abdul Rahman; Syed Zabid Hossain

    2016-01-01

    ... (discretionary accruals) in Bangladesh. The behaviour of corporate accruals is explained by corporate attributes such as asset size, turnover, earnings per share, number of shareholders, year of listing, international link of audit firm...

  13. Design criteria for stable Pt/C fuel cell catalysts.

    Science.gov (United States)

    Meier, Josef C; Galeano, Carolina; Katsounaros, Ioannis; Witte, Jonathon; Bongard, Hans J; Topalov, Angel A; Baldizzone, Claudio; Mezzavilla, Stefano; Schüth, Ferdi; Mayrhofer, Karl J J

    2014-01-01

    Platinum and Pt alloy nanoparticles supported on carbon are the state of the art electrocatalysts in proton exchange membrane fuel cells. To develop a better understanding on how material design can influence the degradation processes on the nanoscale, three specific Pt/C catalysts with different structural characteristics were investigated in depth: a conventional Pt/Vulcan catalyst with a particle size of 3-4 nm and two Pt@HGS catalysts with different particle size, 1-2 nm and 3-4 nm. Specifically, Pt@HGS corresponds to platinum nanoparticles incorporated and confined within the pore structure of the nanostructured carbon support, i.e., hollow graphitic spheres (HGS). All three materials are characterized by the same platinum loading, so that the differences in their performance can be correlated to the structural characteristics of each material. The comparison of the activity and stability behavior of the three catalysts, as obtained from thin film rotating disk electrode measurements and identical location electron microscopy, is also extended to commercial materials and used as a basis for a discussion of general fuel cell catalyst design principles. Namely, the effects of particle size, inter-particle distance, certain support characteristics and thermal treatment on the catalyst performance and in particular the catalyst stability are evaluated. Based on our results, a set of design criteria for more stable and active Pt/C and Pt-alloy/C materials is suggested.

  14. Modeling of PEM fuel cell Pt/C catalyst degradation

    Science.gov (United States)

    Bi, Wu; Fuller, Thomas F.

    Pt/C catalyst degradation remains as one of the primary limitations for practical applications of proton exchange membrane (PEM) fuel cells. Pt catalyst degradation mechanisms with the typically observed Pt nanoparticle growth behaviors have not been completely understood and predicted. In this work, a physics-based Pt/C catalyst degradation model is proposed with a simplified bi-modal particle size distribution. The following catalyst degradation processes were considered: (1) dissolution of Pt and subsequent electrochemical deposition on Pt nanoparticles in cathode; (2) diffusion of Pt ions in the membrane electrode assembly (MEA); and (3) Pt ion chemical reduction in membrane by hydrogen permeating through the membrane from the negative electrode. Catalyst coarsening with Pt nanoparticle growth was clearly demonstrated by Pt mass exchange between small and large particles through Pt dissolution and Pt ion deposition. However, the model is not adequate to predict well the catalyst degradation rates including Pt nanoparticle growth, catalyst surface area loss and cathode Pt mass loss. Additional catalyst degradation processes such as new Pt cluster formation on carbon support and neighboring Pt clusters coarsening was proposed for further simulative investigation.

  15. Design criteria for stable Pt/C fuel cell catalysts

    Directory of Open Access Journals (Sweden)

    Josef C. Meier

    2014-01-01

    Full Text Available Platinum and Pt alloy nanoparticles supported on carbon are the state of the art electrocatalysts in proton exchange membrane fuel cells. To develop a better understanding on how material design can influence the degradation processes on the nanoscale, three specific Pt/C catalysts with different structural characteristics were investigated in depth: a conventional Pt/Vulcan catalyst with a particle size of 3–4 nm and two Pt@HGS catalysts with different particle size, 1–2 nm and 3–4 nm. Specifically, Pt@HGS corresponds to platinum nanoparticles incorporated and confined within the pore structure of the nanostructured carbon support, i.e., hollow graphitic spheres (HGS. All three materials are characterized by the same platinum loading, so that the differences in their performance can be correlated to the structural characteristics of each material. The comparison of the activity and stability behavior of the three catalysts, as obtained from thin film rotating disk electrode measurements and identical location electron microscopy, is also extended to commercial materials and used as a basis for a discussion of general fuel cell catalyst design principles. Namely, the effects of particle size, inter-particle distance, certain support characteristics and thermal treatment on the catalyst performance and in particular the catalyst stability are evaluated. Based on our results, a set of design criteria for more stable and active Pt/C and Pt-alloy/C materials is suggested.

  16. Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

    Science.gov (United States)

    Merritt, Robert B.; Bierwert, Lou Ann; Slatko, Barton; Weiner, Michael P.; Ingram, Jessica; Sciarra, Kristianna; Weiner, Evan

    2008-01-01

    First reported in the early 1930s, variation in the ability to taste phenylthiocarbamide (PTC) has since become one of the most widely studied of all human genetic traits. Guo and Reed (2001) provide an excellent review of work on this polymorphism prior to the identification and sequencing of the PTC gene by Kim et al. (2003), and Wooding (2006)…

  17. 49 CFR 236.1029 - PTC system use and en route failures.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC system use and en route failures. 236.1029..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control Systems § 236.1029 PTC system use and en route failures. (a) When any safety-critical...

  18. Relationship of Phenylthiocarbamide (PTC) Taster Status to Olfactory and Gustatory Function in Patients with Chemosensory Disturbances.

    Science.gov (United States)

    Doty, Richard L; De Fonte, Tatiana Prosini

    2016-10-01

    Poor sensitivity to the bitter taste of phenylthiocarbamide (PTC) and related substances has been associated with a number of diseases. We determined, in patients with chemosensory dysfunction from multiple etiologies, whether PTC "tasters" (n = 511) exhibit less smell and taste dysfunction than their non-PTC-tasting counterparts (n = 432) on a comprehensive battery of olfactory and gustatory tests. The proportion of tasters (54%) in our study population was much lower than that calculated from 11 North American population studies (76.5%; P PTC tasters (P PTC tasting status was unrelated to scores on the olfactory tests (which included tests of odor identification, detection threshold, and odor memory/discrimination), tasters significantly outperformed nontasters on suprathreshold identification and intensity taste tests employing both bitter (caffeine) and nonbitter (sucrose, citric acid, sodium chloride) tasting stimuli. Regardless of PTC taster status, women outperformed men on the taste tests. Our findings suggest the possibility that the T2R38 gene may protect against significant olfactory dysfunction, but once such dysfunction becomes manifest at a level where professional help is sought, such protection is not evident. However, other hypotheses for this phenomenon are possible. This study demonstrates that patients with chemosensory disturbances who are PTC tasters outperform their non-PTC taster counterparts in both identifying and perceiving the intensity of a range of suprathreshold tastants, including ones that do not taste bitter. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Effectiveness of different formulations of Endo-PTC to promote root canal cleaning.

    Science.gov (United States)

    Rodrigues, Evaldo; Albergaria, Sílvio; Barbosa, Gabriela L R; Santoro, Mariana; Pacheco, Paulo; Leal Silva, Emmanuel João Nogueira

    2015-01-01

    Endo-PTC are used during endodontic treatment; however, until now no study evaluated the cleaning of dentin walls after use of different Endo-PTC formulations. The aim of this study was to assess qualitatively, by means of scanning electron microscopy (SEM) images, the cleaning of dentin walls of root canals after chemomechanical preparation (CMP) using Endo-PTC cream and Endo-PTC light associated to 2.5% sodium hypochlorite and 17% ethylenediamine tetraacetate (EDTA). Forty single-rooted human maxillary central incisors with straight canals and fully formed apex were selected. The specimens were randomly divided into four groups depending on the type of Endo-PTC and the final rinse with 17% EDTA. After CMP, all specimens were sectioned and processed for observation of the apical thirds by using SEM. Three calibrated evaluators attributed scores to each specimen. The differences between irrigation protocols were analyzed with Kruskal-Wallis test followed by Bonferroni adjustment for multiple comparisons. The significance level was set at α = 0.05. The use of Endo-PTC cream or Endo-PTC light did not influence the smear-layer (SL) removal (P > 0.05). When EDTA were used, it was obtained the best cleaning results with no significant difference between the substances (P PTC formulation.

  20. Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

    Science.gov (United States)

    Merritt, Robert B.; Bierwert, Lou Ann; Slatko, Barton; Weiner, Michael P.; Ingram, Jessica; Sciarra, Kristianna; Weiner, Evan

    2008-01-01

    First reported in the early 1930s, variation in the ability to taste phenylthiocarbamide (PTC) has since become one of the most widely studied of all human genetic traits. Guo and Reed (2001) provide an excellent review of work on this polymorphism prior to the identification and sequencing of the PTC gene by Kim et al. (2003), and Wooding (2006)…

  1. Corporate Awakening

    DEFF Research Database (Denmark)

    LaFrance, Julie; Lehmann, Martin

    2004-01-01

    Predominantly since the 1992 Rio Summit, corporations have been increasingly pursuing partnerships with public institutions including governments, international organisations and NGOs that aim to contribute to sustainable development activities. Both the business community and public organisations...... are recognizing the potential benefits of public-private partnerships for furthering the Millennium Development Goals while having a positive impact on business. Partnerships have become more common as corporations react to mounting pressure from corporate stakeholders, civil society and government...... on the responsible nature of their business practices. The accountability of corporations has moved beyond the traditional obligations of addressing shareholder demands and today, corporations must be accountable to society and all stakeholders affected by global development. The corporate awakening towards...

  2. Corporate Foundations

    DEFF Research Database (Denmark)

    Herlin, Heidi; Thusgaard Pedersen, Janni

    2013-01-01

    This paper aims to explore the potential of Danish corporate foundations as boundary organizations facilitating relationships between their founding companies and non-governmental organizations (NGOs). Hitherto, research has been silent about the role of corporate foundations in relation to cross......-sector partnerships. The results of this paper are based on interviews, participant observations, and organizational documents from a 19-month empirical study of a Danish corporate foundation. Findings suggest that corporate foundations have potential to act as boundary organizations and facilitate collaborative...... action between business and NGOs through convening, translation, collaboration, and mediation. Our study provides valuable insights into the tri-part relationship of company foundation NGO by discussing the implications of corporate foundations taking an active role in the realm of corporate social...

  3. Estimating the recombination frequency for the PTC-Kell linkage.

    Science.gov (United States)

    Anne-Spence, M; Falk, C T; Neiswanger, K; Field, L L; Marazita, M L; Allen, F H; Siervogel, R M; Roche, A F; Crandall, B F; Sparkes, R S

    1984-01-01

    Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of theta was 0.05. These two new data sets give a combined maximum likelihood estimate of theta m = f = 0.28. Estimating the recombination frequency for the sexes separately gave theta m = 0.29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies.

  4. Optimization study of using PTC for human body heating dissipation

    Directory of Open Access Journals (Sweden)

    Tiberiu Adrian SALAORU

    2014-06-01

    Full Text Available A better knowledge of the human body heat loses mechanisms is important for both diminishing the number of deaths during the surgical procedures of the patients under effect of full anaesthesia and increasing the efficiency of the Heating, Ventilation and Air Conditioning (HVAC systems. For these studies it is necessary to manufacture a human body mannequin having its surface temperature maintained on a value close to the real human body temperature. A number of PTC (Positive Temperature Coefficient thermistors placed on the entire external surface of the mannequin can be used for this purpose. This paper presents a study of the transient heating regime and the stability of the maintained temperature, performed on these devices.

  5. Influence of γ-ray Irradiation on the PTC Effect of EPDM/Carbon Black Composite

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ Introduction The positive temperature coefficient(PTC) effect is characterized by an increase of resistivity with an elevated temperature.The PTC effect of carbon black(CB) filled polymers is useful for self-regulation heaters,over-current protectors,sensors,etc.Much work has been done on the PTC effect of the carbon black filled crystalline polymer composite[1-4],whereas carbon black filled amorphous polymers have not drawn researchers much attention because the PTC effect in these composites is small or cannot be detected[5-7].In this work,the influence of γ-ray irradiation on the PTC effect of CB filled amorphous ethylene-propylene-diene terpolymer(EPDM) composites was studied.

  6. The Analysis on Corporate Technology Innovation Efficiency and Innovation Strategy%企业技术创新效率评估及战略选择

    Institute of Scientific and Technical Information of China (English)

    黄颖; 王勉

    2012-01-01

    技术创新是企业优化资源配置、突破发展瓶颈、提高自身竞争力、实现企业持续发展的重要手段.技术创新效率的研究有利于引导企业关注创新的实际效果,避免创新不足和创新过剩所带来的风险.企业技术创新涉及技术、市场、客户等诸多要素,必须借助创新效率评估模型:区分技术创新和企业核心业务的关联度,明确创新涉及的要素,定性判断创新项目的可行性;利用市场调查等手段,对创新预算以及创新效果经过定量核算.综合利用定性和定量方法,科学、全面地衡量企业的创新效率,且具有良好的可操作性.在创新战略上,需要以企业为主体,强化企业的技术创新主导地位,强化政府的监督、管理功能,提高创新效率.%Technology innovation is critical to corporate competency. It can optimize corporate resources, break the bottleneck, and maintain the sustainable development. The research on technology innovation efficiency can promote the focus on application results; avoid the risk of excessive or insufficient innovation. The technology innovation includes technology, market, customer and other aspects. This paper presents one model to evaluate innovation efficiency. This model measures the correlation between technology innovation and corporate core business. Then it defines the related innovation factors, evaluates the feasibility of innovation project. By the methods of market investigation, it also calculates the budgets and results. By quantity and quality analysis, this model can measure the innovation efficiency well. The innovation strategies are driven by corporate inner motivation, and strengthen the government supervision, enhance the innovation efficiency.

  7. Corporate Taxation and Corporate Governance

    DEFF Research Database (Denmark)

    Köthenbürger, Marko; Stimmelmayr, Michael

    2009-01-01

    interests between shareholders and managers. We set up an agency model and analyze the crucial issue in corporate taxation of whether the normal return on investment should be exempted from taxation. The findings suggest that the divergence of interests may be intensified and welfare reduced...... if the corporate tax system exempts the normal return on investment from taxation. The optimal system may well use the full return on investment as a tax base. Hence, tax systems such as an Allowance for Corporate Equity (ACE) or a Cash-flow tax do not have the familiar efficiency-enhancing effects in the presence......The effects of corporate taxation on firm behavior have been extensively discussed in the neoclassical model of firm behavior which abstracts from agency problems. As emphasized by the corporate governance literature, corporate investment behavior is however crucially influenced by diverging...

  8. Corporate Taxation and Corporate Governance

    DEFF Research Database (Denmark)

    Köthenbürger, Marko; Stimmelmayr, Michael

    2009-01-01

    The effects of corporate taxation on firm behavior have been extensively discussed in the neoclassical model of firm behavior which abstracts from agency problems. As emphasized by the corporate governance literature, corporate investment behavior is however crucially influenced by diverging...... interests between shareholders and managers. We set up an agency model and analyze the crucial issue in corporate taxation of whether the normal return on investment should be exempted from taxation. The findings suggest that the divergence of interests may be intensified and welfare reduced...... if the corporate tax system exempts the normal return on investment from taxation. The optimal system may well use the full return on investment as a tax base. Hence, tax systems such as an Allowance for Corporate Equity (ACE) or a Cash-flow tax do not have the familiar efficiency-enhancing effects in the presence...

  9. 49 CFR 236.1013 - PTC Development Plan and Notice of Product Intent content requirements and Type Approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC Development Plan and Notice of Product Intent... TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control Systems § 236.1013 PTC Development Plan and Notice of Product Intent content requirements and Type Approval. (a) For a PTC system to...

  10. Corporate Language and Corporate Talk

    DEFF Research Database (Denmark)

    Zølner, Mette

    2013-01-01

    the geographical borders by the medium of common corporate values for knowledge management, collection of data and analysis in these studies inspired by approach of ground theory and presents a usefulness of distinguishing between corporate language and talks to enable the headquarters learning. Also it concludes...

  11. RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint.

    Science.gov (United States)

    Marotta, Vincenzo; Guerra, Anna; Sapio, Maria Rosaria; Vitale, Mario

    2011-10-01

    Cytological examination of fine needle aspiration biopsy is the primary means for distinguishing benign from malignant nodules. However, as inconclusive cytology is very frequent, the introduction of molecular markers in the preoperative diagnosis of thyroid nodules has been proposed in recent years. In this article, we review the clinical implications of preoperative detection of rearrangements of the RET gene (RET/papillary thyroid carcinoma (PTC)) in thyroid nodules. The prevalence of RET/PTC in PTC depends on the histological subtypes, geographical factors, radiation exposure, and detection method. Initially, RET/PTC was considered an exclusive PTC hallmark and later it was also found sporadically in benign thyroid lesions. More recently, the very sensitive detection methods, interphase fluorescence in situ hybridization (FISH) and Southern blot on RT-PCR amplicons, demonstrated that the oligoclonal occurrence of RET rearrangement in benign thyroid lesions is not a rare event and suggested that it could be associated with a faster enlargement in benign nodules. For this reason, RET/PTC cannot be considered as an absolute marker of PTC, and its diagnostic application must be limited to assays able to distinguish between clonal and oligoclonal expression. Detection of RET/PTC by quantitative assays will be useful for diagnostic purposes in cytology specimens when a precise cutoff will be fixed in a clinical setting. Until that time, less sensitive RET/PTC detection methods and FISH analysis remain the most appropriate means to refine inconclusive cytology. Future studies with a long follow-up will further clarify the clinical significance of low level of RET rearrangements in benign nodules.

  12. [Pooled Analysis of RET/PTC Gene Rearrangement Rate in Sporadic and Radiogenic Thyroid Papillary Carcinoma].

    Science.gov (United States)

    Ushenkova, L N; Koterov, A N; Biryukov, A P

    2015-01-01

    The database of publications on molecular epidemiology of RET/PTC rearrangements in sporadic and radiogenic thyroid papillary carcinoma has been formed (197 sources at the end of 2014; coverage of 100%). Based on this database a pooled analysis of data on the rates of RET/PTC1, RET/PTC3 and RET/PTC in total was conducted. Statistical approach involves a simple pooling, as well as calculations on the models of random and fixed effects. Since almost all the strata were characterized by heterogeneity, simple pooling and random effect models were adequate. Calculations using both models led to almost identical results. For rates of RET/PTC1, RET/PTC3 and RET/PTC in total with respect to formed carcinoma striations the following values (pooling, in %) were obtained: sporadic, total--13.2; 8.9; 21.2; sporadic, adults--13.3; 9.9; 21.1; sporadic, children--22.4; 17.5; 44.5; radiogenic, total--20.9; 20.3; 40.4; radiotherapy (exposure in childhood)--31.1; 11.8; 42.5; children affected after the Chernobyl accident--19.9; 23.6; 46.1; radiological incidents (exposure in adulthood)--19.9; 7.7; 18.4. Statistically proven is the reliability of differences of carcinoma indicators for children compared with adults (both sporadic and radiogenic tumors) and for radiogenic cancer compared with sporadic. The greatest increase in rate after irradiation was found for RET/PTC1, previously characterized in vitro as one of radiogenic types of RET/PTC.

  13. The Characteristics and Applied Limits for the Test Code ASME PTC6 and ASME PTC46%发电设备性能试验规程ASME PTC6与ASME PTC46的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    王兴平

    2003-01-01

    对美国机械工程师协会汽轮机及全厂性试验规程ASME PTC6与ASME PTC46的目的、方法、边界条件等作了分析论述,着重介绍了ASME PTC46的特点和方法,并根据国内的实际情况,并提出了实际应用方面的建议.表1参4

  14. 公司科技体制机制改革问题探讨%Issues Related to Reform of Corporate Technological Structuring Mechanism

    Institute of Scientific and Technical Information of China (English)

    赵明

    2016-01-01

    The reform of structuring mechanism of the State-owned enterprises is now under the critical stage. From the angle of the State, the reform should be focused on classiifed management of enterprises, return to the economic nature, establishment of modern corporate system, adoption of mixed ownership and capital diversiifcation, and implementation of market-based corporate system for business management. The reform of technological restructuring mechanism should be focused on such areas as promoting marketization of technological sector, establishing the stimulation mechanism for innovation and increase of efifciency, and making full use of employees’ internal enthusiasm for innovation. The reform of restructuring mechanism of CNPC aims at further integration and restructuring of non-listed service businesses, such as engineering technology, engineering construction and equipment manufacturing, while striving for oil and gas industrial development. Those businesses will be brought under corporate system and mixed ownerships and listed on the stock market at an appropriate time for marketization. There are some options for the reform of corporate technological structuring mechanism, such as continual implementation of the two-way mixed management pattern, corporate management system suitable for the headquarters and service enterprises and establishment of the mechanism for operating technological research unit on a company basis.%国企体制机制改革进入关键时期,从国家层面看,改革重点是企业分类管理,回归经济本质,建立现代企业制度,走混合所有、资本多元化道路,实现市场化公司制经营管理;科技体制机制改革主要是推进科技领域市场化,建立搞活人才创新创效激励机制,充分发挥万众创新的内在积极性。中国石油天然气集团公司体制机制改革的重点方向,将是在努力发展油气产业同时,进一步对未上市的工程技术、工程建

  15. Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis.

    Science.gov (United States)

    Wilschanski, M; Miller, L L; Shoseyov, D; Blau, H; Rivlin, J; Aviram, M; Cohen, M; Armoni, S; Yaakov, Y; Pugatsch, T; Pugatch, T; Cohen-Cymberknoh, M; Miller, N L; Reha, A; Northcutt, V J; Hirawat, S; Donnelly, K; Elfring, G L; Ajayi, T; Kerem, E

    2011-07-01

    In a subset of patients with cystic fibrosis (CF), nonsense mutations (premature stop codons) disrupt production of full-length, functional CF transmembrane conductance regulator (CFTR). Ataluren (PTC124) allows ribosomal readthrough of premature stop codons in mRNA. We evaluated drug activity and safety in patients with nonsense mutation CF who took ataluren three times daily (morning, midday and evening) for 12 weeks at either a lower dose (4, 4 and 8 mg·kg(-1)) or higher dose (10, 10 and 20 mg·kg(-1)). The study enrolled 19 patients (10 males and nine females aged 19-57 yrs; dose: lower 12, higher seven) with a classic CF phenotype, at least one CFTR nonsense mutation allele, and an abnormal nasal total chloride transport. Both ataluren doses were similarly active, improving total chloride transport with a combined mean change of -5.4 mV (pataluren administration produced time-dependent improvements in CFTR activity and clinical parameters with generally good tolerability.

  16. PHENYLTHIOCARBAMIDE (PTC TASTER STATUS IN SOUTH INDIAN ADULT MEDICAL STUDENTS

    Directory of Open Access Journals (Sweden)

    Sachin Rathod

    2016-06-01

    Full Text Available BACKGROUND The objective of this study was to determine Phenylthiocarbamide (PTC taster status in adults who are studying medicine and its relationship with anthropometric variables such as Body Mass Index (BMI, Body Fat Percentage (BFP and pleasantness of sugar, salt, and fat. A total of 112 subjects rated the intensity of Phenylthiocarbamide and sodium chloride (NaCl solutions using the labelled magnitude scale. For pleasantness evaluation, it was used with concentrated lemon juice (sugar and mashed potato (salt and fat. The subjects were classified as non-tasters (n=32, medium-tasters (n=31 and super-tasters (n=49. In this study, no relationship was found between phenylthiocarbamide taster status and age, sex, weight, body mass index, and pleasantness. Although genetic markers may influence the degree of liking of certain foods, one must consider that the mechanisms influencing eating behaviour in humans are complex, and that psychological, social, and economic factors play a key role in response to food.

  17. Corporate entrepreneurship

    DEFF Research Database (Denmark)

    Christensen, Karina

    2005-01-01

    Corporate entreprenørskab kan blive svaret på, hvordan Danmark fremmer en mere videnintensiv produktion. Begrebet er blevet anvendt til at forklare forskellige organisatoriske fænomener alt fra strategi over ledelse i al almindelighed til innovation, hvilket har medført en mangfoldighed af begreber...... og perspektiver, som har skabt stor uklarhed omkring corporate entreprenørskab. Med henblik på at skabe fundamentet for et fælles fodslag redegøres der i denne artikel for corporate entreprenørskabsbegrebet ud fra forskellige perspektiver. Der gives i artiklen endvidere et overblik ved hjælp af en...... model, der indeholder intraprenørskab og exoprenørskab, samt fire organisatoriske perspektiver: corporate venturing, interne ressourcer, internationalisering og eksterne netværk....

  18. Corporate Foresight at Cisco

    DEFF Research Database (Denmark)

    Rohrbeck, René; Bøe-Lillegraven, Siri

    Cisco Systems traditional innovation model is challenged. It is no longer possible to simply scout for promising start-ups, integrate them and grow them globally to succeed. This case describes the challenge faced by Cisco to create a comprehensive and systematic strategic foresight system...... that shall be tied into technology strategy and corporate business development. The case elaborates on the process and the best practices in the introduction of the Cisco Technology Radar approach....

  19. Corporate Responsibility

    OpenAIRE

    World Bank

    2004-01-01

    Appeals to corporate responsibility often simply take for granted that businesses have ethical responsibilities that go beyond just respecting the law. This paper addresses arguments to the effect that businesses have no such responsibilities. The interesting claim is not that businesses have no ethical responsibility at all but that their primal responsibility is to increase their profits. The extent to which there is reason to take such arguments seriously delineates the limits of corporate...

  20. [Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates].

    Science.gov (United States)

    Guerra, Anna; Carrano, Mario; Angrisani, Elisabetta; Vitale, Mario

    2013-01-01

    Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.

  1. Examining corporate governance and corporate tax management

    Directory of Open Access Journals (Sweden)

    Martin Surya Mulyadi

    2014-07-01

    Full Text Available Taxation play an essential role both in a country and in a corporation. For a country it is one of the primary income source, while for the corporation taxes will reduce corporate net income. To minimize the tax payment, corporation conduct a corporate tax management. According to some of previous research, there is a correlation between corporate governance and corporate tax management. While there are many corporate governance proxies could be used in corporate governance research, in this research we are focusing on three: number of board, number of independent board and board compensation. We measure corporate tax management by using effective tax rate (GAAP ETR and current ETR are used in this research. By using several other control variables, we run the regression and conduct the statistical analysis to examine the correlation between corporate governance and corporate tax management. Our result show that corporate governance have a significant correlation to corporate tax management.

  2. A Study on Prevalence of Phenyl Thiocarbamide (PTC) Taste Blindness Among Obese Individuals.

    Science.gov (United States)

    Veluswami, Deepika; Meena, B Ambigai; Latha, S; Fathima, I Gayathri; Soundariya, K; Selvi, K Senthamil

    2015-05-01

    Taste blindness to the phenylthiocarbamide (PTC) is an inherited trait that is shown to influence our food and dietary preferences which in turn influence our body weight. Obesity is a global epidemic issue known to be on rise among the developing countries. Relating taste perception to obesity, the present study was undertaken to assess the prevalence of phenylthiocarbamide (PTC) taste blindness among obese individuals. Three hundred and fifty individuals of age group 20-40 y were recruited from the local community for the present cross sectional study. Anthropometric measurements were taken and BMI was calculated. Subjects were classified as underweight, normal, overweight and obese based on their BMI. Normal, overweight and obese individuals were then asked to taste the commercially available PTC test papers and classified as non tasters and tasters of PTC. Out of 350 individuals, mean age group of 30±6.02 y, based on their BMI they were divided into 4 groups, Group A-underweight (16%), Group B-normal (35%), Group C-overweight (28%) and Group D-obese (21%) individuals. In group B, 28% were non tasters of PTC and 65% were tasters. In group C, 82% were non tasters and 13% were tasters and in Group D, 81% were non tasters and 19% were tasters of PTC. The PTC non taster phenotype individuals showed higher BMI as compared with the tasters' phenotype. Exploring the novel connections between taste perception and obesity would help us to gain a control over the global epidemic-Obesity, which is the crux factor for various other health problems. The study advocates the usage of PTC tasting as a reliable indicator of weight gain susceptibility.

  3. Preparation of Pt/C Catalyst with Solid Phase Reaction Method

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Pt/C catalyst was prepared with solid phase reaction method (Pt/C(S)) for the first time. Its performances were compared with that prepared by the traditional liquid phase reaction method. The results demonstrate that the electrocatalytic activity of Pt/C catalyst with solid phase reaction method for methanol oxidation is higher than that with liquid phase reaction method. XRD and TEM measurements indicate that the Pt/C(S) possesses low crystalline extent and small particle size.

  4. Telecommunications--Asia, Americas, Pacific: PTC '86. "Evolution of the Digital Pacific." Proceedings of the Annual Meeting of the Pacific Telecommunications Council (8th, Honolulu, Hawaii, January 12-15, 1986).

    Science.gov (United States)

    Wedemeyer, Dan J., Ed.; Pennings, Anthony J., Ed.

    The eighth Annual Pacific Telecommunications Conference (PTC) proceedings contain 61 papers related to the conference theme, "Evolution of the Digital Pacific." These papers look at the ramifications of future technological breakthroughs and transitional needs. The first two days of the conference focused on state-of-the-art developments…

  5. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - BAGHOUSE FILTRATION PRODUCTS - BASF CORPORATION AX/BA-14/9-SAXP FILTER SAMPLE

    Science.gov (United States)

    Baghouse filtration products (BFPs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the mean outlet particle concentration for the filter fabric as a function of th...

  6. Transcriptional control of Shh/Ptc1 signaling in embryonic development.

    Science.gov (United States)

    Lin, Shi-Lung; Chang, Shin-Ju E; Ying, Shao-Yao

    2006-02-15

    In vivo profiling of signal-directed gene expression patterns is a major bottleneck in studying developmental biology. A signal molecule initiates its specific gene expression pattern through the activation of certain transcription factor (TF); however, tissue heterogeneity often masks this pattern due to intercellular complexity of other signal transduction pathways. To decipher the synergistic regulation of signal-directed gene expression in the tissue level, we report here a unique transcriptional responsive element (TRE) existing in the 5'-upstream promoter regions (5'-UPR) of the genes responding to the Shh/Ptc1 signal transduction pathway during feather placode development in chicken embryos. By locating the TRE homologue and its interactive TF, we were able to reveal the gene expression pattern of the Shh/Ptc1 signaling. We firstly demonstrated that homology profiling of the 5'-UPR of the genes, Gli1, TGF-beta2 and Msx2, responding to the Shh/Ptc1 signaling showed a more than 70% conserved region. Computer alignment of the consensus sequences in the conserved region revealed a 37-nucleotide TRE sequence, containing two regulatory elements homologous to human and mouse Gli-binding sites. Activation of this newly identified Shh/Ptc1-responsive TRE by active Smo signaling in chicken hepatoepithelial carcinoma cells elicited a strong synergistic expression of the Shh/Ptc1-downstream genes. Based on previous bioinformatics and the present experimental findings, we successfully established an in vivo signaling model for the Shh/Ptc1-directed embryonic feather morphogenesis.

  7. Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation.

    Science.gov (United States)

    Jeong, Woo-Jin; Mo, Ji-Hun; Park, Min Woo; Choi, Ik Joon; An, Soo-Youn; Jeon, Eun-Hee; Ahn, Soon-Hyun

    2011-09-01

    Sunitinib, a multi-targeted tyrosine kinase inhibitor, is frequently incorporated into the management of papillary thyroid carcinoma refractory to standard therapies. Although clinical trials are in progress, the mechanism of action in papillary thyroid carcinomas is not clear, especially regarding the effect on BRAF mutation. We investigated the effect of sunitinib on papillary thyroid carcinoma cells harboring RET/PTC rearrangement and BRAF mutation using TPC-1M, SNU-790, and B-cPAP cell lines. Cell growth of papillary thyroid cancer cells with RET/PTC rearrangement was effectively inhibited at low doses of sunitinib (IC50=0.658 μM), whereas that of BRAF mutated cells required higher doses. Immunoblotting revealed effective blocking of MEK/ERK pathway in RET/PTC rearrangement cells, but not in BRAF mutated cells. Cell cycle analysis showed G1 arrest in RET/PTC rearrangement cells. In vivo orthotopic thyroid cancer mouse model demonstrated statistically significant tumor growth inhibition by sunitinib in RET/PTC rearrangement cancer cells. We conclude that sunitinib effectively inhibits RET/PTC rearrangement cells but not BRAF mutated cells. These data suggest that sunitinib exerts its effect by inhibiting the upstream MAPK signaling cascade. These findings support the unsatisfactory treatment outcomes of sunitinib in many already ongoing clinical trials compared to other tyrosine kinase inhibitors. Clinical application of sunitinib should be directed accordingly.

  8. Corporate Governance

    Directory of Open Access Journals (Sweden)

    Dragoș-Mihail Daghie

    2011-05-01

    Full Text Available The purpose of this study is to analyze and understand the recently introduced form of managementof a company limited by shares. The Law no. 441/2006, which fundamentally amended Company Law,created this form of controlling the company, the corporate governance, but the legislation does not explicitlydefine what it wants to achieve through this instrument. This topic is recent in research as the theme ofgerman-roman commercial law systems (in French corporate governance system was introduced in 1966 andin Romania in 2006 but in terms of Anglo-Saxon law, the topic has been addressed years since 1776 (AdamSmith: The Wealth of Nations The concept of corporate governance would like, as a result, to establish somerules that companies must comply in order to achieve effective governance, transparent and beneficial forboth shareholders and for the minority. Corporate governance is a key element with an aim at improvingefficiency and economic growth in full accordance with the increase of investors’ confidence. Corporategovernance assumes a series of relationship between the company management, leadership, shareholders andthe other people concerned. Also corporate governance provides for that structure by means of which thecompany’s targets are set out and the means to achieve them and also the manner how to monitor such.

  9. CORPORATE GOVERNANCE

    Directory of Open Access Journals (Sweden)

    Dan Alexandru SITARU

    2009-10-01

    Full Text Available The work is aimed to examine the issues “corporate governance” involves, with the goal set to clarify the meanings of such notion, and to provide an overall image of the positive effects arising implementing the corporate governance principles. The first section includes a series of definitions for the purpose of explaining and outlining the concept of “corporate governance”, subsequently giving a definition that appears adequate to us, from the legal standpoint pre eminently. The second section has for purpose to state the corporate governance Principles, and briefly examine the same. Its purpose also includes concretely illustrating the efficient operation methods for a “corporation”, as well as the main dilemmas, and the existing solutions for the same within the internal structure of a joint stock company to adopt, and subject itself to, such principles. Finally, the last section of the work underlines the corporate governance importance, and states the goals to be attained for purposes of securing effective, balanced, and not in the last place profitable management.

  10. Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC.

    Science.gov (United States)

    Hu, Jianxia; Li, Chengqian; Liu, Chongkai; Zhao, Shihua; Wang, Yangang; Fu, Zhengju

    2017-01-01

    The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low, it is essential to develop novel diagnostic and prognostic biomarkers for PTC. To explore the expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues and plasma and their associations with the clinical characteristics of PTC. We investigated the expressions of miR-940, miR-15a, miR-16 and IL-23 in plasma and thyroid tissues of PTC, nodular goiter and healthy people with qRT-PCR, and further analyzed the associations between their levels and the clinical characteristics of PTC. Level of IL-23 expression was higher while levels of miR-940, miR-15a and miR-16 expression in the PTC tissues were lower compared with the nodular goiter tissues and perineoplastic thyroid tissues. And the levels of miR-940, miR-15a, miR-16 and IL-23 expression in the PTC tissues were associated with some clinical characteristics of PTC, including bilateral tumor, multicentricity, extrallyroidal invasion, cervical lymph node metastasis, distant metastasis and clinical advanced stages (III/IV). Expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues might be useful biomarkers and promising targets in the diagnosis of papillary thyroid carcinoma.

  11. Corporate Entrepreneurship

    DEFF Research Database (Denmark)

    Lassen, Astrid Heidemann

    Corporate entrepreneurship is often highlighted as being more relevant than ever, as a viable means for existing organizations to pursue creative new solutions to the complex challenges facing firms today. This includes continuously exploring and exploiting previously unexploited opportunities, a...... entrepreneurship and innovation, and identifying management practices supportive of these particular innovation processes.......Corporate entrepreneurship is often highlighted as being more relevant than ever, as a viable means for existing organizations to pursue creative new solutions to the complex challenges facing firms today. This includes continuously exploring and exploiting previously unexploited opportunities......, and thereby moving the organization to a new state of being. In spite of a general consensus on a strong interlinkage between the concepts of innovation and corporate entrepreneurship, the nature of this linkage is rarely addressed directly. This has made further research in the two areas problematic, mainly...

  12. Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.

    Science.gov (United States)

    George, Jonathan R; Henderson, Ying C; Williams, Michelle D; Roberts, Dianna B; Hei, Hu; Lai, Stephen Y; Clayman, Gary L

    2015-12-01

    Papillary thyroid carcinoma (PTC) carrying the BRAF mutation has been reported to be associated with high recurrence and potentially increased mortality. PTC carrying the TERT promoter mutation has been associated with older age, recurrence, and aggressive disease. The objective of this study was to determine the association of BRAF and TERT promoter gene alterations with recurrence and survival in a high-risk population. Genomic DNA was analyzed for the BRAF mutation from 256 persistent/recurrent PTC (p/rPTC; 202 new, 54 previously reported) and for the TERT promoter mutation and polymorphism (242 p/rPTC). Two-tailed Fisher exact tests or the Pearson χ(2) test were performed for the associations between mutations and other variables. Overall and disease-free survivals were compared by log rank tests on Kaplan-Meier plots and by Cox regression analysis. TERT promoter constructs were tested in PTC cell lines to determine their activities in these cells. BRAF V600E mutation was identified in 235 of 256 (91.8%), TERT promoter mutation at -124 was detected in 77 of 242 (31.8%), and TERT promoter polymorphism at -245 was found in 113 of 242 (46.7%) p/rPTC patients. A significant difference in survival was found in p/rPTC patients with the TERT promoter mutation, which also displayed increased activity in vitro as compared to the nonmutated promoter sequence. No association was noted between the BRAF mutation or TERT promoter polymorphism and recurrence or survival. A drawback of our study could be the limited number of patients with nonmutated BRAF (21 of 256 [8.2%]). Mutation in the TERT promoter, but not in BRAF, was associated with decreased survival in 19 (24.7%) p/rPTC patients who died of disease and in 38 (49.4%) p/rPTC patients who died at last contact. The presence or absence of the BRAF mutation and TERT promoter polymorphism, however, was not significantly correlated with survival.

  13. Corporate responsibility

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint

    2007-01-01

    Is it legitimate for a business to concentrate on profits under respect for the law and ethical custom? On the one hand, there seems to be good reasons for claiming that a corporation has a duty to act for the benefit of all its stakeholders. On the other hand, this seems to dissolve the notion...... to this paradox as Goodpaster, namely that a corporation is the instrument of the shareholders only, but that shareholders still have an obligation to act ethically responsibly. To this, I add discussion of Friedman's claim that this responsibility consists in increasing profits. I show that most of his arguments...

  14. Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae.

    Science.gov (United States)

    Sharmin, Dilruba; Sasano, Yu; Sugiyama, Minetaka; Harashima, Satoshi

    2015-04-01

    The phosphorylation status of cellular proteins results from an equilibrium between the activities of protein kinases and protein phosphatases (PPases). Reversible protein phosphorylation is an important aspect of signal transduction that regulate many biological processes in eukaryotic cells. The Saccharomyces cerevisiae genome encodes 40 PPases, including seven members of the protein phosphatase 2C subfamily (PTC1 to PTC7). In contrast to other PPases, the cellular roles of PTCs have not been investigated in detail. Here, we sought to determine the cellular role of PTC6 in S. cerevisiae with disruption of PTC genes. We found that cells with Δptc6 disruption were tolerant to the cell wall-damaging agents Congo red (CR) and calcofluor white (CFW); however, cells with simultaneous disruption of PTC1 and PTC6 were very sensitive to these agents. Thus, simultaneous disruption of PTC1 and PTC6 gave a synergistic response to cell wall damaging agents. The level of phosphorylated Slt2 increased significantly after CR treatment in Δptc1 cells and more so in Δptcptc6 cells; therefore, deletion of PTC6 enhanced Slt2 phosphorylation in the Δptc1 disruptant. The level of transcription of KDX1 upon exposure to CR increased to a greater extent in the Δptcptc6 double disruptant than the Δptc1 single disruptant. The Δptcptc6 double disruptant cells showed normal vacuole formation under standard growth conditions, but fragmented vacuoles were present in the presence of CR or CFW. Our analyses indicate that S. cerevisiae PTC6 participates in the negative regulation of Slt2 phosphorylation and vacuole morphogenesis under cell wall stress conditions.

  15. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

    Energy Technology Data Exchange (ETDEWEB)

    Auld, Douglas S.; Lovell, Scott; Thorne, Natasha; Lea, Wendy A.; Maloney, David J.; Shen, Min; Rai, Ganesha; Battaile, Kevin P.; Thomas, Craig J.; Simeonov, Anton; Hanzlik, Robert P.; Inglese, James (NIH); (Kansas); (HWMRI)

    2010-04-07

    Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 Ataluren; (3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid) discovered in an FLuc-based assay targeting nonsense codon suppression, is an unusually potent FLuc-inhibitor. Paradoxically, PTC124 and related analogs increase cellular FLuc activity levels by posttranslational stabilization. In this study, we show that FLuc inhibition and stabilization is the result of an inhibitory product formed during the FLuc-catalyzed reaction between its natural substrate, ATP, and PTC124. A 2.0 {angstrom} cocrystal structure revealed the inhibitor to be the acyl-AMP mixed-anhydride adduct PTC124-AMP, which was subsequently synthesized and shown to be a high-affinity multisubstrate adduct inhibitor (MAI; KD = 120 pM) of FLuc. Biochemical assays, liquid chromatography/mass spectrometry, and near-attack conformer modeling demonstrate that formation of this novel MAI is absolutely dependent upon the precise positioning and reactivity of a key meta-carboxylate of PTC124 within the FLuc active site. We also demonstrate that the inhibitory activity of PTC124-AMP is relieved by free coenzyme A, a component present at high concentrations in luciferase detection reagents used for cell-based assays. This explains why PTC124 can appear to increase, instead of inhibit, FLuc activity in cell-based reporter gene assays. To our knowledge, this is an unusual example in which the 'off-target' effect of a small molecule is mediated by an MAI mechanism.

  16. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

    Science.gov (United States)

    Auld, Douglas S.; Lovell, Scott; Thorne, Natasha; Lea, Wendy A.; Maloney, David J.; Shen, Min; Rai, Ganesha; Battaile, Kevin P.; Thomas, Craig J.; Simeonov, Anton; Hanzlik, Robert P.; Inglese, James

    2010-01-01

    Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren; (3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid) discovered in an FLuc-based assay targeting nonsense codon suppression, is an unusually potent FLuc-inhibitor. Paradoxically, PTC124 and related analogs increase cellular FLuc activity levels by posttranslational stabilization. In this study, we show that FLuc inhibition and stabilization is the result of an inhibitory product formed during the FLuc-catalyzed reaction between its natural substrate, ATP, and PTC124. A 2.0 Å cocrystal structure revealed the inhibitor to be the acyl-AMP mixed-anhydride adduct PTC124-AMP, which was subsequently synthesized and shown to be a high-affinity multisubstrate adduct inhibitor (MAI; KD = 120 pM) of FLuc. Biochemical assays, liquid chromatography/mass spectrometry, and near-attack conformer modeling demonstrate that formation of this novel MAI is absolutely dependent upon the precise positioning and reactivity of a key meta-carboxylate of PTC124 within the FLuc active site. We also demonstrate that the inhibitory activity of PTC124-AMP is relieved by free coenzyme A, a component present at high concentrations in luciferase detection reagents used for cell-based assays. This explains why PTC124 can appear to increase, instead of inhibit, FLuc activity in cell-based reporter gene assays. To our knowledge, this is an unusual example in which the “off-target” effect of a small molecule is mediated by an MAI mechanism. PMID:20194791

  17. High growth rate of benign thyroid nodules bearing RET/PTC rearrangements.

    Science.gov (United States)

    Sapio, Maria Rosaria; Guerra, Anna; Marotta, Vincenzo; Campanile, Elisabetta; Formisano, Raffaele; Deandrea, Maurilio; Motta, Manuela; Limone, Paolo Piero; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario

    2011-06-01

    Benign thyroid nodules display a broad range of behaviors from a stationary size to a progressive growth. The RET/PTC oncogene has been documented in a fraction of benign thyroid nodules, besides papillary thyroid carcinomas, and it might therefore influence their growth. The aim of the present work was to evaluate whether RET/PTC in benign thyroid nodules associates with a different nodular growth rate. In this prospective multicentric study, 125 subjects with benign nodules were included. RET rearrangements were analyzed in cytology samples; clinical and ultrasonographic nodule characteristics were assessed at the start and at the end of the study. RET/PTC was present in 19 nodules. The difference between the mean baseline nodular volume of the RET/PTC- and RET/PTC+ nodules was not significant. After 36 months of follow-up, the RET/PTC+ group (n = 16) reached a volume higher than the RET/PTC- group (n = 90) (5.04 ± 2.67 vs. 3.04 ± 2.26 ml; P = 0.0028). We calculated the monthly change of nodule volumes as a percentage of baseline. After a mean follow-up of 36.6 months, the monthly volume increase of nodules bearing a RET rearrangement was 4.3-fold that of nodules with wild-type RET (1.83 ± 1.2 vs. 0.43 ± 1.0% of baseline volume; P < 0.0001). Benign thyroid nodules bearing RET rearrangements grow more rapidly than those with wild-type RET. Searching for RET rearrangements in benign thyroid nodules might be useful to the clinician in choosing the more appropriate and timely therapeutic option.

  18. Corporate Governance and Corporate Creditworthiness

    Directory of Open Access Journals (Sweden)

    Dror Parnes

    2011-12-01

    Full Text Available We examine the relation between corporate governance and bankruptcy risk as an underlying force affecting a bond’s yield. The level of corporate governance is captured by the G-index, along with the explicit groups of governance provisions. We estimate bankruptcy risk by Z-score, by cash-flow-score, by O-score, through Merton structural model default probabilities, and by S&P credit ratings. After addressing endogeneity and while controlling for firm-specific factors, based on the four objective methodologies we find that corporate governance is inversely related to bankruptcy risk. Yet, rating agencies take a mixed approach towards this association likely because of the conflicting impact of different governance provisions.

  19. Characterization and vectorization of siRNA targeting RET/PTC1 in human papillary thyroid carcinoma cells

    Directory of Open Access Journals (Sweden)

    Massade L.

    2011-10-01

    Full Text Available RET/PTC1 fusion oncogene is the most common genetic alteration identified to date in thyroid papillary carcinomas (PTC and represents a good target for small interfering RNA (siRNA. Our aim was: i to target the RET/PTC1 oncogene by siRNAs, ii to assess the knockdown effects on cell growth and cell cycle regulation and iii to vectorize it in order to protect it from degradation. Methods. Human cell lines expressing RET/PTC1 were transfected by siRNA RET/PTC1, inhibition of the oncogene expression was assessed by qRT-PCR and by Western blot. Conjugation of siRNA RET/PTC1 to squalene was performed by coupling it to squalene. In vivo studies are performed in nude mice. Conclusion. In this short communication, we report the main published results obtained during last years.

  20. Dynamics of reflection of corporal potential of teenagers under act of employments on the offered technology of fitness.

    Directory of Open Access Journals (Sweden)

    Kibal'nik Oksana Yakovlevna

    2011-09-01

    Full Text Available The main point of presented fitness-technologies conception is in natural combination of modern trends and means of health-improving fitness and theoretical knowledge of its use. The aim of the work is efficiency assessment of developed technologies. The effect of these technologies on the level of teenagers self-realisation of their own physical experience and peculiarities of their life prospects design was studied. It was proved that under the effect of experiment factor the quantity of teenagers, who more positively conceive No. 1, show confidence in goals achievement, are ready to overcome misfortune due to their possibilities and self-activity, is increased.

  1. Structural and electronic properties of bulk and low-index surfaces of zincblende PtC

    Science.gov (United States)

    Gokhan Sensoy, Mehmet; Toffoli, Daniele; Ustunel, Hande

    2017-03-01

    Transition metal carbides have been extensively used in diverse applications over the past decade. Their versatility is in part thanks to their unique bonding, which displays a mixture of ionic, metallic and covalent character. While the bulk structure of zincblende (ZB) PtC has been investigated several times, a detailed understanding of the electronic and structural properties of its low-index surfaces is lacking. In this work, we present an ab initio investigation of the properties of five crystallographic ZB PtC surfaces (Pt/C-terminated PtC(1 0 0), PtC(1 1 0) and Pt/C-terminated PtC(1 1 1)). Upon geometry optimization, both polar and nonpolar surfaces undergo a mild interlayer relaxation, without extensive reconstructions. Calculated vacancy formation energies indicate facile C removal on the (1 1 1) surface while Pt-vacancy formation is endothermic. Finally, atomic O adsorption energies on all surfaces reveal a high affinity of the C-terminated surfaces towards this species.

  2. Activity improvement of Pt/C catalysts by adding CeO2 nanoparticles

    Institute of Scientific and Technical Information of China (English)

    YANG Yuying; ZHANG Ziyu; HU Zhongai

    2011-01-01

    Carbon-supported platinum catalysts were prepared by NaBH4 reduction of metal precursors and the CeO2 nanoparticles were prepared by citric acid sol-gel method. The structure and morphology of two kinds of nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM), respectively. The Pt particles were uniformly dispersed on the carbon surface and showed the rod-like morphology. The CeO2 was spherical in shape. The appropriate amount of CeO2 nanoparticles was added into Pt/C systems to improve activity of the catalysts. Several electrochemical techniques such as cyclic voltammogram (CV), chronoamperometry (I-t)and electrochemical impedance spectroscopy (EIS) were used to investigate the properties of CeO2-Pt/C catalysts for methanol electrooxidation in 1 mol/L CH3OH+0.5H2SO4 aqueous solutions. The results revealed that compared with Pt/C catalysts CeO2-pt/C exhibited a higher activity and stability for methanol electro-oxidation. Moreover, the effect of CeO2 content on the activity of Pt/C catalysts was discussed in detail.

  3. Evaluation of Annual Modis Ptc Data for Deforestation and Forest Degradation Analysis

    Science.gov (United States)

    Gao, Y.; Ghilardi, A.; Mas, J. F.; Paneque-Galvez, J.; Skutsch, M.

    2016-06-01

    Anthropogenic land-cover change, e.g. deforestation and forest degradation cause carbon emissions. To estimate deforestation and forest degradation, it is important to have reliable data on forest cover. In this analysis, we evaluated annual MODIS Percent Tree Cover (PTC) data for the detection of forest change including deforestation, forest degradation, reforestation and revegetation. The annual MODIS PTC data (2000 - 2010) were pre-processed by applying quality layer. Based on the PTC values of the annual MODIS data, forest change maps were produced and assessed by comparing with the data from visual interpretation of SPOT-5 images. The assessment was applied to two case-studies: Ayuquila Basin and Monarch Reserve. Results show that the detected deforestation patches by visual interpretation are roughly 4 times in quantity more than those by MODIS PTC data, which can be partially due to the much higher spatial resolution of SPOT-5, being able to pick up small deforestation patches. This analysis found poor spatial overlapping for both case-studies. Possible reasons for the discrepancy in quantity and spatial coincidence were provided. It is necessary to refine the methodology for forest change detection by PTC images; also to refine the validation data in terms of data periods and forest change categories to ensure a better assessment.

  4. Permission to contact (PTC)--a strategy to enhance patient engagement in translational research.

    Science.gov (United States)

    Cheah, Stefanie; O'Donoghue, Sheila; Daudt, Helena; Dee, Simon; LeBlanc, Jodi; Braun, Lauren; Barnes, Rebecca; Vercauteren, Suzanne; Boone, Robert H; Watson, Peter H

    2013-08-01

    Improving patient recruitment and consent to participate in clinical studies is an important issue. The process of consent involves three steps: patient referral for contact, the preliminary interview to determine patient interest, and the informed consent discussion. We hypothesized that putting the first step of the consent process into a 'Permission to Contact' (PTC) platform would improve patient engagement, would improve the efficiency of the other steps of the process, and would be acceptable to diverse patient groups. To test this hypothesis, four PTC platforms were established in three types of outpatient health clinics (cancer, cardiac, maternal health) in different British Columbia health centers. Each began as a research project where clinic personnel were engaged, clinic flow processes were mapped, and a design for each PTC was derived by consensus. All patients at these clinics were asked for 'permission to be contacted for future research purposes.' Patient approach and permission response rates were assessed and operational costs were estimated. Overall permission rates were high for all projects, but ranged from 94% of 'cancer' patients to 80% of 'congenital heart' patients who were approached (pPTC platform is a feasible mechanism to engage patients in research programs such as biobanking. It is well supported by clinic staff and receives high engagement and acceptance from patients. Patient-approach rates vary in different clinics, likely due to both clinic and PTC process factors, but this strategy provides an efficient means of engaging patients in research and sets the stage for enhanced enrollment into translational research programs.

  5. RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas.

    Science.gov (United States)

    de Vries, Margriet M; Celestino, Ricardo; Castro, Patricia; Eloy, Catarina; Máximo, Valdemar; van der Wal, Jacqueline E; Plukker, John T M; Links, Thera P; Hofstra, Robert M W; Sobrinho-Simões, Manuel; Soares, Paula

    2012-11-01

    The molecular alterations underlying follicular Hürthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hürthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. We investigated a series of 20 follicular Hürthle cell tumours [17 FHCCs and three follicular Hürthle cell adenomas (FHCAs)]. RET/PTC rearrangements were found in 33% of FHCAs and in 38% of FHCCs. All RET/PTC-positive FHCCs had a solid pattern of growth. PAX8/PPARG rearrangement was present in 27% of the FHCCs which displayed, in most cases, a follicular architecture. NRAS mutation was detected in one FHCC. An FHCC with a solid/microfollicular growth pattern scored positive for both RET/PTC and PAX8/PPARG rearrangement. Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment. © 2012 Blackwell Publishing Limited.

  6. Structural and electronic properties of bulk and low-index surfaces of zincblende PtC.

    Science.gov (United States)

    Sensoy, Mehmet Gokhan; Toffoli, Daniele; Ustunel, Hande

    2017-03-29

    Transition metal carbides have been extensively used in diverse applications over the past decade. Their versatility is in part thanks to their unique bonding, which displays a mixture of ionic, metallic and covalent character. While the bulk structure of zincblende (ZB) PtC has been investigated several times, a detailed understanding of the electronic and structural properties of its low-index surfaces is lacking. In this work, we present an ab initio investigation of the properties of five crystallographic ZB PtC surfaces (Pt/C-terminated PtC(1 0 0), PtC(1 1 0) and Pt/C-terminated PtC(1 1 1)). Upon geometry optimization, both polar and nonpolar surfaces undergo a mild interlayer relaxation, without extensive reconstructions. Calculated vacancy formation energies indicate facile C removal on the (1 1 1) surface while Pt-vacancy formation is endothermic. Finally, atomic O adsorption energies on all surfaces reveal a high affinity of the C-terminated surfaces towards this species.

  7. Performance Characteristics of PTC Elements for an Electric Vehicle Heating System

    Directory of Open Access Journals (Sweden)

    Yoon Hyuk Shin

    2016-10-01

    Full Text Available A high-voltage positive temperature coefficient (PTC heater has a simple structure and a swift response. Therefore, for cabin heating in electric vehicles (EVs, such heaters are used either on their own or with a heat pump system. In this study, the sintering process in the manufacturing of PTC elements for an EV heating system was improved to enhance surface uniformity. The electrode production process entailing thin-film sputtering deposition was applied to ensure the high heating performance of PTC elements and reduce the electrode thickness. The allowable voltage and surface heat temperature of the high-voltage PTC elements with thin-film electrodes were 800 V and 172 °C, respectively. The electrode layer thickness was uniform at approximately 3.8 μm or less, approximately 69% less electrode materials were required compared to that before process improvement. Furthermore, a heater for the EV heating system was manufactured using the developed high-voltage PTC elements to verify performance and reliability.

  8. 3rd August 2010 - CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt, signing the guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1008148 11: H. von Dewitz in the ATLAS Visitor centre with Collaboration member M. Hauschild (left) and Former IT Department Head W. von Rüden (right) CERN-HI-1008148 18 : Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid (left) in the ATLAS Visitor centre with Collaboration member M. Hauschild. CERN-HI-1008148: in the ATLAS visitor centre, from left to right: Former IT Department Head W. von Rüden; ATLAS Collaboration P. Mättig; CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt; Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid; H. von Dewitz; ATLAS Collaboration member M. Hauschild.

  9. A novel RET/PTC variant detected in a pediatric patient with papillary thyroid cancer without ionization history.

    Science.gov (United States)

    Halkova, Tereza; Dvorakova, Sarka; Vaclavikova, Eliska; Sykorova, Vlasta; Vcelak, Josef; Sykorova, Pavla; Vlcek, Petr; Reboun, Martin; Katra, Rami; Kodetova, Daniela; Schrumpf, Melanie; van Wezel, Tom; Morreau, Hans; Bendlova, Bela

    2015-12-01

    Papillary thyroid carcinoma (PTC) is the most frequent type of thyroid cancer. Its development is often caused by the formation of RET/PTC fused genes. RET/PTC1 is the most prevalent form, where exon 1 of CCDC6 gene is fused with the intracellular portion of RET protooncogene starting with exon 12. We have discovered a novel RET/PTC1 variant which we have named RET/PTC1ex9 in metastatic PTC of 8-year-old boy. RET/PTC1ex9 detection was performed by real-time polymerase chain reaction with melting curve analysis and subsequent Sanger and next-generation sequencing. A fusion of exon 1 of CCDC6 with exon 9 of extracellular domain of RET followed by exon 12 of RET was revealed. This is the first RET/PTC variant among PTC cases that contain the extracellular part of RET. This observation could be probably explained by incorrect splicing of RET due to the somatic 32-bp deletion in exon-intron 11 boundary of RET. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. STUDY ON THE OPTIMIZATION OF IGBT THERMAL MANAGEMENT FOR PTC HEATER

    Directory of Open Access Journals (Sweden)

    J. W. JEONG

    2015-12-01

    Full Text Available It is essential to optimize HVAC (Heating, Ventilation and Air-Conditioning system for a thermal plant or an electric vehicle since it has a significant effect on the thermal efficiency. PTC (positive temperature coefficient heaters are often used for a heating system and the power module of the PTC heaters, IGBT (insulated gate bipolar mode transistor, requires thermal management. In this study, in order to maximize the cooling performance for IGBT, a novel method that uses forced convection inside the HVAC duct with heat sinks was developed. In addition, heat sinks were optimized in terms of IGBT junction temperature and heat sink weight by 3-dimensional CFD (Computational Fluid Dynamics simulation. The results show that the junction temperature of IGBT for 5.6kW PTC heater can be maintained at about 335K.

  11. Design of a Low-Frequency Oscillator with PTC Memristor and an Inductor

    Science.gov (United States)

    Rajamani, Vetriveeran; Yang, Changju; Kim, Hyongsuk; Chua, Leon

    An electronic oscillator circuit is designed by connecting an inductor in series with a locally-active PTC Memristor and a battery. The PTC Memristor is locally active on the negative resistance region of its DC VM-IM curve. A DC operating point Q is chosen on the locally-active region of the PTC Memristor and a small-signal equivalent circuit at Q is derived via Taylor series. The small-signal admittance YCM(s; V ) of the composite one-port in Fig. 1 is derived using the small-signal equivalent circuit at Q, in series with an inductor whose value is chosen such that YCM(iω0; V ) = 0 at some s = iω0. The sinusoidal oscillation computed numerically from this circuit is shown to emerge from a supercritical Hopf bifurcation.

  12. Multiplex minisequencing screening for PTC genotype associated with bitter taste perception.

    Science.gov (United States)

    Sagong, Borum; Bae, Jae Woong; Rhyu, Mee Ra; Kim, Un-Kyung; Ye, Mi-Kyung

    2014-03-01

    Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In this study, we developed a tool for genotyping of these SNPs in the TAS2R38 gene using SNaPshot minisequencing and investigated the accuracy of the tool in 100 subjects who were genotyped by Sanger sequencing. The minor allele frequencies of the three SNPs were 0.39, and these genotypes corresponded to those determined by direct sequencing. In conclusion, we successfully developed a precise and rapid genetic tool for analysis of PTC genotype associated with bitter taste perception.

  13. Assessing RET/PTC in thyroid nodule fine-needle aspirates: the FISH point of view.

    Science.gov (United States)

    Caria, Paola; Dettori, Tinuccia; Frau, Daniela V; Borghero, Angela; Cappai, Antonello; Riola, Alessia; Lai, Maria L; Boi, Francesco; Calò, Piergiorgio; Nicolosi, Angelo; Mariotti, Stefano; Vanni, Roberta

    2013-08-01

    RET/PTC rearrangement and BRAF(V600E) mutation are the two prevalent molecular alterations associated with papillary thyroid carcinoma (PTC), and their identification is increasingly being used as an adjunct to cytology in diagnosing PTC. However, there are caveats associated with the use of the molecular approach in fine-needle aspiration (FNA), particularly for RET/PTC, that should be taken into consideration. It has been claimed that a clonal or sporadic presence of this abnormality in follicular cells can distinguish between malignant and benign nodules. Nevertheless, the most commonly used PCR-based techniques lack the capacity to quantify the number of abnormal cells. Because fluorescence in situ hybridization (FISH) is the most sensitive method for detecting gene rearrangement in a single cell, we compared results from FISH and conventional RT-PCR obtained in FNA of a large cohort of consecutive patients with suspicious nodules and investigated the feasibility of setting a FISH-FNA threshold capable of distinguishing non-clonal from clonal molecular events. For this purpose, a home brew break-apart probe, able to recognize the physical breakage of RET, was designed. While a ≥3% FISH signal for broken RET was sufficient to distinguish nodules with abnormal follicular cells, only samples with a ≥6.8% break-apart FISH signal also exhibited positive RT-PCR results. On histological analysis, all nodules meeting the ≥6.8% threshold proved to be malignant. These data corroborate the power of FISH when compared with RT-PCR in quantifying the presence of RET/PTC in FNA and validate the RT-PCR efficiency in detecting clonal RET/PTC alterations.

  14. Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

    Science.gov (United States)

    Pibiri, Ivana; Lentini, Laura; Melfi, Raffaella; Gallucci, Giulia; Pace, Andrea; Spinello, Angelo; Barone, Giampaolo; Di Leonardo, Aldo

    2015-08-28

    Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat these diseases is to promote the translational readthrough of premature stop codons by small molecules aiming to restore the full-length protein. The compound PTC124 (Ataluren) was reported to promote the readthrough of the premature UGA stop codon, although its activity was questioned. The potential interaction of PTC124 with mutated mRNA was recently suggested by molecular dynamics (MD) studies highlighting the importance of H-bonding and stacking π-π interactions. To improve the readthrough activity we changed the fluorine number and position in the PTC124 fluoroaryl moiety. The readthrough ability of these PTC124 derivatives was tested in human cells harboring reporter plasmids with premature stop codons in H2BGFP and FLuc genes as well as in cystic fibrosis (CF) IB3.1 cells with a nonsense mutation. Maintaining low toxicity, three of these molecules showed higher efficacy than PTC124 in the readthrough of the UGA premature stop codon and in recovering the expression of the CFTR protein in IB3.1 cells from cystic fibrosis patient. Molecular dynamics simulations performed with mutated CFTR mRNA fragments and active or inactive derivatives are in agreement with the suggested interaction of PTC124 with mRNA. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  15. Essential PTC Mathcad Prime 3.0 a guide for new and current users

    CERN Document Server

    Maxfield, Brent

    2013-01-01

    Learn how to use PTC Mathcad Prime 3.0, one of the world's leading tools for technical computing, in the context of engineering, science, and math applications. Quickly harness the power of Mathcad to solve simple and complex problems. Essential PTC Mathcad is perfect for college students and first-time users as well as for experienced Mathcad users who are moving to Prime 3.0. The book introduces the most powerful functions and features of the new Prime 3.0 software and teaches how to apply them to create comprehensive calculations for any quantitative subject. Examples from several fields

  16. Steady-state solution of the PTC thermistor problem using a quadratic spline finite element method

    Directory of Open Access Journals (Sweden)

    Bahadir A. R.

    2002-01-01

    Full Text Available The problem of heat transfer in a Positive Temperature Coefficient (PTC thermistor, which may form one element of an electric circuit, is solved numerically by a finite element method. The approach used is based on Galerkin finite element using quadratic splines as shape functions. The resulting system of ordinary differential equations is solved by the finite difference method. Comparison is made with numerical and analytical solutions and the accuracy of the computed solutions indicates that the method is well suited for the solution of the PTC thermistor problem.

  17. Study on "two-circle" Structure for Corporate Technological Innovation%企业自主创新内驱动力的“二环结构”研究

    Institute of Scientific and Technical Information of China (English)

    杜靖

    2012-01-01

    企业是自主创新的主体,只有创新内驱动力充足企业才可能进行自主创新。在企业自主创新的内驱动力中,包含着核心驱动力和内部驱动力。各种内驱动力起着不同的交互作用,企业家的创新精神与创新的企业文化是企业自主创新的核心驱动力,创新的投资收益、资源、成功期望、失败风险是企业自主创新的内部驱动力。在此基础上,对企业自主创新内驱动力的结构进行研究,提出了企业自主创新内驱动力的"二环结构",以获取最为有效的企业自主创新内驱动力,从而推动企业自主创新成功。%Enterprise is the main body for independent technological innovation,but only when it has sufficient driving forces in technological innovation,independent technological innovation can be carried out.Corporate internal driving forces include core driving forces,internal driving forces.Different internal driving forces play different interactive roles.Enterpriser's innovative mind and innovative corporate culture are the core driving forces for corporate independent innovation;innovative investment benefit,resources,successful expectations,and failure-risk are the internal driving forces for corporate independent innovation.On this basis,this paper studies the structure of internal driving forces for corporate independent innovation,puts forward the "two-circle" structure for corporate independent innovation to obtain the most effective the structure of internal driving forces for corporate independent innovation to make the corporate independent innovation succeed.

  18. RET/PTC Rearrangements Are Associated with Elevated Postoperative TSH Levels and Multifocal Lesions in Papillary Thyroid Cancer without Concomitant Thyroid Benign Disease.

    Science.gov (United States)

    Su, Xuan; He, Caiyun; Ma, Jiangjun; Tang, Tao; Zhang, Xiao; Ye, Zulu; Long, Yakang; Shao, Qiong; Shao, Jianyong; Yang, Ankui

    2016-01-01

    RET/PTC rearrangements, resulting in aberrant activity of the RET protein tyrosine kinase receptor, occur exclusively in papillary thyroid cancer (PTC). In this study, we examined the association between RET/PTC rearrangements and thyroid hormone homeostasis, and explored whether concomitant diseases such as nodular goiter and Hashimoto's thyroiditis influenced this association. A total of 114 patients diagnosed with PTC were enrolled in this study. Thyroid hormone levels, clinicopathological parameters and lifestyle were obtained through medical records and surgical pathology reports. RET/PTC rearrangements were detected using TaqMan RT-PCR and validated by direct sequencing. No RET/PTC rearrangements were detected in benign thyroid tissues. RET/PTC rearrangements were detected in 23.68% (27/114) of PTC tissues. No association between thyroid function, clinicopathological parameters and lifestyle was observed either in total thyroid cancer patients or the subgroup of patients with concomitant disease. In the subgroup of PTC patients without concomitant disease, RET/PTC rearrangement was associated with multifocal cancer (P = 0.018). RET/PTC rearrangement was also correlated with higher TSH levels at one month post-surgery (P = 0.037). Based on likelihood-ratio regression analysis, the RET/PTC-positive PTC cases showed an increased risk of multifocal cancers in the thyroid gland (OR = 5.57, 95% CI, 1.39-22.33). Our findings suggest that concomitant diseases such as nodular goiter and Hashimoto's thyroiditis in PTC may be a confounding factor when examining the effects of RET/PTC rearrangements. Excluding the potential effect of this confounding factor showed that RET/PTC may confer an increased risk for the development of multifocal cancers in the thyroid gland. Aberrantly increased post-operative levels of TSH were also associated with RET/PTC rearrangement. Together, our data provides useful information for the treatment of papillary thyroid cancer.

  19. Corporate Fictions

    DEFF Research Database (Denmark)

    Staunæs, Dorthe; Søndergaard, D. M.

    2006-01-01

    The article describes a particular strategy of communication called a social science fiction. The strategy was taken up following an empirical research project on gender and management, in order to communicate results to the company's managers and Human Resource Staff. The research results showed...... fiction was the kind of narrative therapy, which aims to reconfigure the problem in focus by a process of externalisation that allows a reconstruction and retelling of the issue. The article describes how three cultural mechanisms in the company were condensed into three imaginary figures: Mr. Corporate...

  20. Corporate Foresight

    DEFF Research Database (Denmark)

    Rohrbeck, René; Gemünden, Hans Georg

    2011-01-01

    Although in the last three decades much knowledge has been produced on how best to conduct foresight exercises, but little is known on how foresight should be integrated with the innovation effort of a company. Drawing on empirical evidence from 19 case studies and 107 interviews, we identify three...... roles that corporate foresight should play to maximize the innovation capacity of a firm: (1) the strategist role, which explores new business fields; (2) the initiator role, which increases the number of innovation concepts and ideas; and (3) the opponent role, which challenges innovation projects...

  1. Corporate Fictions

    DEFF Research Database (Denmark)

    Staunæs, Dorthe; Søndergaard, D. M.

    2006-01-01

    The article describes a particular strategy of communication called a social science fiction. The strategy was taken up following an empirical research project on gender and management, in order to communicate results to the company's managers and Human Resource Staff. The research results showed...... fiction was the kind of narrative therapy, which aims to reconfigure the problem in focus by a process of externalisation that allows a reconstruction and retelling of the issue. The article describes how three cultural mechanisms in the company were condensed into three imaginary figures: Mr. Corporate...

  2. Corporate Foresight

    DEFF Research Database (Denmark)

    Rohrbeck, René; Gemünden, Hans Georg

    2011-01-01

    Although in the last three decades much knowledge has been produced on how best to conduct foresight exercises, but little is known on how foresight should be integrated with the innovation effort of a company. Drawing on empirical evidence from 19 case studies and 107 interviews, we identify three...... roles that corporate foresight should play to maximize the innovation capacity of a firm: (1) the strategist role, which explores new business fields; (2) the initiator role, which increases the number of innovation concepts and ideas; and (3) the opponent role, which challenges innovation projects...

  3. 外部治理对企业技术创新影响的理论分析%The Theoretical Analysis of the Effect of External Governance on Corporate Technology Innovation

    Institute of Scientific and Technical Information of China (English)

    周颖生; 史宝娟

    2012-01-01

    With the deeper and deeper openness of the world economy and the emerging systems of complex products, the relationship between the corporate and the external environment is becoming closer and closer. Depending on this , this article analysises the effects of factors of external governance on corporate technology innovation, giving the advices that the corporate should recognize the important effect and the positive and neg- ative factors to make good use of the effect of external governance mechanisms on corporate technology innovation.%归纳了外部治理所包含的10个具体的因素,并结合物理学的力学模型分析了外部治理的10个要素对企业技术创新的影响,然后,提出了考虑中间作用的企业技术创新动力机制模型,因此建议企业要识别其中的积极因素与消极因素,更好的发挥其对企业技术创新的作用。

  4. Hydrogenation of fructose to 2,5-dimethyltetrahydrofuran using a sulfur poisoned Pt/C catalyst

    Science.gov (United States)

    In order to expand the number of biobased chemicals available, fructose has been hydrogenated to 2,5-dimethyltetrahydrofuran using a sulfided Pt/C catalyst. The reaction was carried out in a stirred reactor at 10.3 MPa H2 and 175°C which allowed a 10% fructose solution to be converted in about 2 h. ...

  5. Mediation as Problem-Solving Scene in the Light of PTC

    Directory of Open Access Journals (Sweden)

    Viktor Németh

    2014-05-01

    Full Text Available Mediation does not only mean a specific procedure or protocol but the related attitude, mindset as well. This perspective gives opportunity to demonstrate the problem in a different way than previously. In the present study, the Participatory Theory of Communication (PTC appears as a framework which makes the communication of participants of the mediation interpretable and transparent.

  6. Implications of a PTC Extension on U.S. Wind Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.; Steinberg, D.; Mendelsohn, M.; Zinaman, O.; James, T.; Porro, G.; Hand, M.; Mai, T.; Logan, J.; Heeter, J.; Bird, L.

    2014-04-01

    This analysis explores the potential effects of wind production tax credit expiration and various extension scenarios on future wind deployment with the Regional Energy Deployment System (ReEDS), a model of the U.S. electricity sector. The analysis does not estimate the potential implications on government tax revenue associated with the PTC. Key findings include: Under a scenario in which the PTC is not extended and all other policies remain unchanged, wind capacity additions are expected to be between 3 and 5 GW per year from 2013-2020; PTC extension options that ramp-down from the current level to zero-credit by year-end 2022 appear to be insufficient to support deployment at the recent historical average; Extending the PTC at its historical level may provide the best opportunity to support deployment consistent with recent levels across a range of potential market conditions; it therefore may also provide the best opportunity to sustain wind power installation and manufacturing sector at current levels.

  7. Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells.

    Science.gov (United States)

    Califano, D; Monaco, C; de Vita, G; D'Alessio, A; Dathan, N A; Possenti, R; Vecchio, G; Fusco, A; Santoro, M; de Franciscis, V

    1995-07-06

    The expression of the receptor-like tyrosine kinase RET is associated with tumors, tissues or cell lines of neural crest origin. In addition RET products (Ret) are involved in determining cell fate during the differentiation of the enteric nervous system and during renal organogenesis. However, as yet, no direct evidence exists to indicate that the Ret kinase activity might interfere in a specific way with cellular differentiation, or proliferation, of a neural crest derived cell line. By using two constitutively activated forms of RET (RET/PTC1 and RET/PTC3) in transient transfection experiments, we have obtained evidence that active RET could reprogramme the gene expression pattern in the rat pheochromocytoma PC12 cell line. Transcription driven by gene promoters, such as NGFI-A and vgf, which belong, respectively, to primary and delayed response genes to nerve growth factor (NGF), and by the neuron-specific enolase (NSE) promoter, is rapidly induced by the expression of activated RET oncogenes. This induction is not elicited in other non neural derived cell types tested. We also demonstrate that endogenous ras activity is required for RET induction of these neural markers. Finally, in the RET/PTC transfected PC12 cells, NGF is unable to induce further their transcription. This suggests that RET/PTC could share an intracellular signalling pathway with the NGF-receptor.

  8. High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence.

    Science.gov (United States)

    Winkelströter, Lizziane K; Bom, Vinícius Leite Pedro; de Castro, Patrícia Alves; Ramalho, Leandra Naira Zambelli; Goldman, Maria Helena S; Brown, Neil Andrew; Rajendran, Ranjith; Ramage, Gordon; Bovier, Elodie; Dos Reis, Thaila Fernanda; Savoldi, Marcela; Hagiwara, Daisuke; Goldman, Gustavo H

    2015-04-01

    Aspergillus fumigatus is a fungal pathogen that is capable of adapting to different host niches and to avoid host defenses. An enhanced understanding of how, and which, A. fumigatus signal transduction pathways are engaged in the regulation of these processes is essential for the development of improved disease control strategies. Protein phosphatases are central to numerous signal transduction pathways. To comprehend the functions of protein phosphatases in A. fumigatus, 32 phosphatase catalytic subunit encoding genes were identified. We have recognized PtcB as one of the phosphatases involved in the high osmolarity glycerol response (HOG) pathway. The ΔptcB mutant has both increased phosphorylation of the p38 MAPK (SakA) and expression of osmo-dependent genes. The ΔptcB strain was more sensitive to cell wall damaging agents, had increased chitin and β-1,3-glucan, and impaired biofilm formation. The ΔptcB strain was avirulent in a murine model of invasive pulmonary aspergillosis. These results stress the importance of the HOG pathway in the regulation of pathogenicity determinants and virulence in A. fumigatus.

  9. 49 CFR 236.1006 - Equipping locomotives operating in PTC territory.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Equipping locomotives operating in PTC territory. 236.1006 Section 236.1006 Transportation Other Regulations Relating to Transportation (Continued... territory. (a) Except as provided in paragraph (b) of this section, each train operating on any...

  10. Catalytic Liquefaction of Humin Substances from Sugar Biorefineries with Pt/C in 2-Propanol

    NARCIS (Netherlands)

    Wang, Y.; Agarwal, S.; Heeres, H. J.

    The catalytic liquefaction of humins, the solid byproduct from the conversion of C6 sugars (glucose, fructose) to S-hydroxymethylfurfural (HMF) and levulinic acid (LA), using a supported Pt/C catalyst in isopropanol (IPA) as the solvent was investigated. At bench mark conditions (400 degrees C, 7 h,

  11. When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

    Science.gov (United States)

    Shalev, Moran; Baasov, Timor

    2014-08-01

    Aminoglycosides (AGs) are highly potent antibacterial agents, which are known to exert their deleterious effects on bacterial cells by interfering with the translation process, leading to aberrant protein synthesis that usually results in cell death. Nearly 45 years ago, AGs were shown to induce read-through activity in prokaryotic systems by selectively encoding tRNA molecules at premature termination codon (PTC) positions; resulting in the generation of full length functional proteins. However, only in the last 20 years this ability has been demonstrated in eukaryotic systems, highlighting their potential as therapeutic agents to treat PTC induced genetic disorders. Despite the great potential, AGs use in these manners is quite restricted due to relatively high toxicity values observed upon their administration. Over the last few years several synthetic derivatives were developed to overcome some of the enhanced toxicity issues, while in parallel showed significantly improved PTC suppression activity in various in-vitro, ex-vivo and in-vivo models of a variety of different diseases models underling by PTC mutations. Although these derivatives hold great promise to serve as therapeutic candidates they also demonstrate the necessity to further understand the molecular mechanisms of which AGs confer their biological activity in eukaryotic cells for further rational drug design. Recent achievements in structural research shed light on AGs mechanism of action and opened a new avenue in the development of new and improved therapeutic derivatives. The following manuscript highlights these accomplishments and summarizes their contributions to the state of art rational drug design.

  12. RET/PTC rearrangement is prevalent in follicular Hurthle cell carcinomas

    NARCIS (Netherlands)

    de Vries, Margriet M.; Celestino, Ricardo; Castro, Patricia; Eloy, Catarina; Maximo, Valdemar; van der Wal, Jacqueline E.; Plukker, John T. M.; Links, Thera P.; Hofstra, Robert M. W.; Sobrinho-Simoes, Manuel; Soares, Paula

    2012-01-01

    Aims: The molecular alterations underlying follicular Hurthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hurthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. Methods and result

  13. PTC 2005: Pulaski Technical College's Strategic Plan for Serving Central Arkansas.

    Science.gov (United States)

    Johnson, Mark

    Intended as a long-range agenda for Arkansas' Pulaski Technical College (PTC), this plan describes the planning process used at the college, sets forth college goals through the year 2005, and reviews strategies to help the college achieve its goals. Following introductory sections, the educational and training needs of Central Arkansas are…

  14. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.

    Science.gov (United States)

    Gu, Yulu; Liu, Xiaoli; Yu, Yaqin; Shi, Jieping; Ai, Lizhe; Sun, Hui; Kanu, Joseph Sam; Wang, Chong; Liu, Yawen

    2014-01-01

    Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions and is related to invasion and metastasis of malignancy. The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. In this study, we want to investigate whether ATM polymorphisms are associated with gender-specific metastasis of PTC. 358 PTC patients in Northern China, including 109 males and 249 females, were included in our study. Four ATM single nucleotide polymorphisms (SNPs) were genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). Association between genotypes and the gender-specific risk of metastasis was assessed by odds ratios (OR) and 95% confidence intervals (CI) under the unconditional logistic regression analysis. Significant associations were observed between rs189037 and metastasis of PTC in females under different models of inheritance (codominant model: OR = 0.15, 95% CI 0.04-0.56, P = 0.01 for GA versus GG and OR = 0.08, 95% CI 0.01-0.74, P = 0.03 for AA versus GG, resp.; dominant model: OR = 0.49, 95% CI 0.25-0.98, P = 0.04; overdominant model: OR = 0.47, 95% CI 0.25-0.89, P = 0.02). However, no association remained significant after Bonferroni correction. Our findings suggest a possible association between ATM rs189037 polymorphisms and metastasis in female PTCs.

  15. High-Throughput Screening for Readthrough Modulators of CFTR PTC Mutations.

    Science.gov (United States)

    Liang, Feng; Shang, Haibo; Jordan, Nikole J; Wong, Eric; Mercadante, Dayna; Saltz, Josef; Mahiou, Jerome; Bihler, Hermann J; Mense, Martin

    2017-02-01

    Cystic fibrosis (CF) is a hereditary disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). A large number of nearly 2000 reported mutations, including the premature termination codon (PTC) mutations, urgently require new and personalized medicines. We have developed cell-based assays for readthrough modulators of CFTR PTC mutations (or nonsense mutation suppressors), based on the trafficking and surface expression of CFTR. Approximately 85,000 compounds have been screened for two PTC mutations (Y122X and W1282X). The hit rates at the threshold of 50% greater than vehicle response are 2% and 1.4% for CFTR Y122X and CFTR W1282X, respectively. The overlap of the two hit sets at this stringent hit threshold is relatively small. Only ~28% of the hits from the W1282X screen were also hits in the Y122X screen. The overlap increases to ~50% if compounds are included that in the second screen achieve only a less stringent hit criterion, that is, horseradish peroxidase (HRP) activity greater than three standard deviations above the mean of the vehicle. Our data suggest that personalization may not need to address individual genotypes, but that patients with different CFTR PTC mutations could benefit from the same medicines.

  16. The Management Mechanism Design of Corporate Entrepreneurship

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The corporate entrepreneurship has become an important part in the business mana gement as well as a worldwide fashion. Traditional management idealism, organiza tion structure, management technology and enterprise culture have influenced the further step of the whole process to some extent. Therefore, manager should sea rch for the plausible management mechanism with an aim to support the corporate entrepreneurship. It includes strengthening the corporate risk-taking, setting up motivation mechanism for...

  17. 标杆学习对企业主流与新流创新的影响%The Impact of Benchmarking on Corporate Mainstream and Newstream Technology Innovation

    Institute of Scientific and Technical Information of China (English)

    方金城; 朱斌

    2016-01-01

    标杆学习对企业主流与新流技术创新均具有促进作用,但不同类型的标杆学习对两种技术创新具有不同的影响效应与作用机理。竞争性标杆学习和功能性标杆学习,分别通过以直接影响为主和间接影响为主的综合作用路径,正向促进企业主流技术创新;两类标杆学习对企业新流技术创新的促进效应均通过间接影响路径起作用。组织惯例更新在标杆学习影响企业主流技术创新中起部分中介作用,而在标杆学习影响企业新流技术创新中则起完全中介作用。%Benchmarking can promote corporate mainstream and newstream technology innovation;but different types of benchmarking present diverse effects with different mechanisms. Competitive benchmarking and functional benchmarking positively promote enterprises’mainstream technology innovation by comprehensive acting paths based on direct influence and indirect influence,respectively. The promotion effects of these two types of benchmarking on corporate newstream technology innovation are both through indirect path. Organizational routine update plays partial intermediary role in influencing corporate mainstream technology innovation by benchmarking, while it plays complete intermediary role in influencing corporate mainstream technology innovation by benchmarking.

  18. MIR141 expression differentiates Hashimoto Thyroiditis from PTC and benign thyrocytes in Irish archival thyroid tissues

    Directory of Open Access Journals (Sweden)

    Emma R Dorris

    2012-09-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs approximately 22 nucleotides in length that function as regulators of gene expression. Dysregulation of miRNAs has been associated with initiation and progression of oncogenesis in humans. Our group has previously described a unique miRNA expression signature, including the MIR200 family member MIR141, which can differentiate papillary thyroid cancer (PTC cell lines from a control thyroid cell line. An investigation into the expression of MIR141 in a series of archival thyroid malignancies (n=140; classic PTC, follicular variant PTC, follicular thyroid carcinoma (FTC, Hashimoto thyroiditis (HT, or control thyrocytes was performed. Each cohort had a minimum of 20 validated samples surgically excised within the period 1980 - 2009. A subset of the HT and cPTC cohorts (n=3 were also analysed for expression of TGFβR1, a key member of the TGFβ pathway and known target of MIR141. Laser capture microdissection was used to specifically dissect target cells from formalin-fixed paraffin-embedded archival tissue. Thyrocyte- and lymphocyte-specific markers (TSHR and LSP1 respectively confirmed the integrity of cell populations in the HT cohort. RNA was extracted and quantitative RT-PCR was performed using comparative CT (ΔΔCT analysis. Statistically significant (p<0.05 differential expression profiles of MIR141 were found between tissue types. HT samples displayed significant downregulation of MIR141 compared to both classic PTC and control thyrocytes. Furthermore, TGFβR1 expression was detected in cPTC samples but not in HT thyrocytes. It is postulated that the down-regulation of this miRNA is due, at least in part, to its involvement in regulating the TGFβ pathway. This pathway is exquisitely involved in T-cell autoimmunity and has previously been linked with HT. In conclusion, HT epithelium can be distinguished from cPTC epithelium and control epithelium based on the relative expression of MIR141.

  19. Upregulation of Shh and Ptc1 in hyperoxia‑induced acute lung injury in neonatal rats.

    Science.gov (United States)

    Dang, Hongxing; Wang, Shaohua; Yang, Lin; Fang, Fang; Xu, Feng

    2012-08-01

    The aim of the present study was to observe the expression of sonic hedgehog (Shh) and Ptc signaling molecules in the lungs of newborn rats exposed to prolonged hyperoxia, and to explore the role of the SHH signaling pathway in hyperoxia‑induced lung injury. Newborn Sprague-Dawley rat pups were placed in chambers containing room air or oxygen above 95% for 14 days following birth. The rats were sacrificed after 3, 7 or 14 days and their lungs were removed. Sections were fixed and subjected to hematoxylin and eosin (H&E) staining. Shh and Ptc1 were quantitated by immunohistochemistry. The total RNA and protein were also extracted from lung tissue; real-time PCR (RT-PCR) and western blot analysis were utilized to assess the mRNA and protein expression of Shh and Ptc1. H&E staining demonstrated significant histomorphological changes in the hyperoxia‑exposed lungs at 3, 7 and 14 days of age. The results of the immunohistochemistry, RT-PCR and western blot analysis demonstrated that the expression of Shh was significantly higher in the hyperoxia-exposed lungs at 3, 7 and 14 days, while Ptc1 was significantly elevated at 7 and 14 days. Exposure of the neonatal rat lung to prolonged hyperoxia resulted in acute lung injury and histomorphological changes. Shh and Ptc1 were upregulated in a time-dependent manner in the course of hyperoxia-induced lung injury. The SHH signal pathway may be involved in the pathogenesis of hyperoxia-induced lung injury. This is the first evidence that in vivo hyperoxia induces activation of the SHH signal transduction pathway in newborn lung.

  20. Use of a combined SpO₂/PtcCO₂ sensor in the delivery room.

    Science.gov (United States)

    Rubortone, Serena Antonia; De Carolis, Maria Pia; Lacerenza, Serafina; Bersani, Iliana; Occhipinti, Federica; Romagnoli, Costantino

    2012-01-01

    Arterial oxygen saturation (SaO(2)) and partial arterial pressure of carbon dioxide (PaCO(2)) are important respiratory parameters in critically ill neonates. A sensor combining a pulse oximeter with the Stow-Severinghaus electrode, required for the measurement of peripheral oxygen saturation (SpO(2)) and transcutaneous partial pressure of carbon dioxide (PtcCO(2)), respectively, has been recently used in neonatal clinical practice (TOSCA(500Ò)Radiometer). We evaluated TOSCA usability and reliability in the delivery room (DR), throughout three different periods, on term, late-preterm, and preterm neonates. During the first period (period A), 30 healthy term neonates were simultaneously monitored with both TOSCA and a MASIMO pulse oximeter. During the second period (period B), 10 healthy late-preterm neonates were monitored with both TOSCA and a transcutaneous device measuring PtcCO(2) (TINA(Ò) TCM3, Radiometer). During the third period (period C), 15 preterm neonates were monitored with TOSCA and MASIMO after birth, during stabilization, and during transport to the neonatal intensive care unit (NICU). Blood gas analyses were performed to compare transcutaneous and blood gas values. TOSCA resulted easily and safely usable in the DR, allowing reliable noninvasive SaO(2) estimation. Since PtcCO(2) measurements with TOSCA required at least 10 min to be stable and reliable, this parameter was not useful during the early resuscitation immediately after birth. Moreover, PtcCO(2) levels were less precise if compared to the conventional transcutaneous monitoring. However, PtcCO(2) measurement by TOSCA was useful as trend-monitoring after stabilization and during transport to NICU.

  1. Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

    Science.gov (United States)

    Auld, Douglas S.; Thorne, Natasha; Maguire, William F.; Inglese, James

    2009-01-01

    High-throughput screening (HTS) assays used in drug discovery frequently use reporter enzymes such as firefly luciferase (FLuc) as indicators of target activity. An important caveat to consider, however, is that compounds can directly affect the reporter, leading to nonspecific but highly reproducible assay signal modulation. In rare cases, this activity appears counterintuitive; for example, some FLuc inhibitors, acting through posttranslational Fluc reporter stabilization, appear to activate gene expression. Previous efforts to characterize molecules that influence luciferase activity identified a subset of 3,5-diaryl-oxadiazole-containing compounds as FLuc inhibitors. Here, we evaluate a number of compounds with this structural motif for activity against FLuc. One such compound is PTC124 {3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid}, a molecule originally identified in a cell-based FLuc assay as having nonsense codon suppression activity [Welch EM, et al., Nature (2007) 447:87–91]. We find that the potency of FLuc inhibition for the tested compounds strictly correlates with their activity in a FLuc reporter cell-based nonsense codon assay, with PTC124 emerging as the most potent FLuc inhibitor (IC50 = 7 ± 1 nM). However, these compounds, including PTC124, fail to show nonsense codon suppression activity when Renilla reniformis luciferase (RLuc) is used as a reporter and are inactive against the RLuc enzyme. This suggests that the initial discovery of PTC124 may have been biased by its direct effect on the FLuc reporter, implicating firefly luciferase as a molecular target of PTC124. Our results demonstrate the value of understanding potential interactions between reporter enzymes and chemical compounds and emphasize the importance of implementing the appropriate control assays before interpreting HTS results. PMID:19208811

  2. Corporate ethic policy

    OpenAIRE

    Хадарцева, Лариса; Кайтмазов, Владимир

    2014-01-01

    The article deals with the general concept of business ethics, a corporate code of ethics and corporate social responsibility. Corporations take pains to promote sustainability through codes of ethics and their efforts are positively received by consumers.

  3. Nanostructured electrocatalyst for fuel cells : silica templated synthesis of Pt/C composites.

    Energy Technology Data Exchange (ETDEWEB)

    Stechel, Ellen Beth; Switzer, Elise E.; Fujimoto, Cy H.; Atanassov, Plamen Borissov; Cornelius, Christopher James; Hibbs, Michael R.

    2007-09-01

    Platinum-based electrocatalysts are currently required for state-of-the-art fuel cells and represent a significant portion of the overall fuel cell cost. If fuel cell technology is to become competitive with other energy conversion technologies, improve the utilization of precious metal catalysts is essential. A primary focus of this work is on creating enhanced nanostructured materials which improve precious-metal utilization. The goal is to engineer superior electrocatalytic materials through the synthesis, development and investigation of novel templated open frame structures synthesized in an aerosol-based approach. Bulk templating methods for both Pt/C and Pt-Ru composites are evaluated in this study and are found to be limited due to the fact that the nanostructure is not maintained throughout the entire sample. Therefore, an accurate examination of structural effects was previously impossible. An aerosol-based templating method of synthesizing nanostructured Pt-Ru electrocatalysts has been developed wherein the effects of structure can be related to electrocatalytic performance. The aerosol-based templating method developed in this work is extremely versatile as it can be conveniently modified to synthesize alternative materials for other systems. The synthesis method was able to be extended to nanostructured Pt-Sn for ethanol oxidation in alkaline media. Nanostructured Pt-Sn electrocatalysts were evaluated in a unique approach tailored to electrocatalytic studies in alkaline media. At low temperatures, nanostructured Pt-Sn electrocatalysts were found to have significantly higher ethanol oxidation activity than a comparable nanostructured Pt catalyst. At higher temperatures, the oxygen-containing species contribution likely provided by Sn is insignificant due to a more oxidized Pt surface. The importance of the surface coverage of oxygen-containing species in the reaction mechanism is established in these studies. The investigations in this work present

  4. DOE/Industrial Technologies Program DOE Award Number DE-FG36-05GO15099 Plant Wide Energy Efficiency Assessment Pilgrims Pride Corporation – Mt Pleasant Facility

    Energy Technology Data Exchange (ETDEWEB)

    Paper, Riyaz; Dooley, Bill; Turpish, William J; Symonds, Mark; Carswell, Needham

    2007-04-13

    The U. S. Department of Energy’s (DOE) Industrial Technologies Program (ITP), through Oak Ridge National Laboratory, is supporting plant wide energy efficiency assessments that will lead to substantial improvements in industrial efficiency, waste reduction, productivity, and global competitiveness in industries identified in ITP’s Industries of the Future. The stated goal of the assessments is to develop a comprehensive strategy at manufacturing locations that will significantly increase plant productivity, profitability, and energy efficiency, and reduce environmental emissions. ITP awarded a contract to Pilgrim’s Pride Corporation to conduct a plant wide energy efficiency assessment for their Mt Pleasant Facility in Mt Pleasant, Texas. Pilgrim’s Pride Corporation is the largest poultry company in the U.S. and Mexico producing nearly 9 billion pounds of poultry per year. Pilgrim's Pride products are sold to foodservice, retail and frozen entrée customers. Pilgrim's Pride owns and operates 37 chicken processing plants (34 in the U.S. and three in Mexico), 12 prepared foods plants and one turkey processing plant. Thirty-five feed mills and 49 hatcheries support these plants. Pilgrim's Pride is ranked number 382 on 2006's FORTUNE 500 list and net sales were $7.4 billion. In Mt. Pleasant, Texas, Pilgrim's Pride operates one of the largest prepared foods plants in the United States, with the capability of producing 2,000 different products and the capacity to turn out more than 7 million pounds of finished goods per week. The facility is divided into distinct departments: East Kill, West Kill, Prepared Foods, Protein Conversion, Wastewater Treatment, and Truck Shop. Facility processes include killing, eviscerating, refrigeration, baking, frying, and protein conversion. Pilgrim’s Pride formed a team to complete the plant wide energy efficiency assessment. The scope of work for this project was to: provide the analysis of departmental

  5. Managing Corporate Reputation Through Corporate Branding

    DEFF Research Database (Denmark)

    Schultz, Majken; Hatch, Mary Jo; Adams, Nick

    2012-01-01

    This article, which concentrates on symbolic management by explaining the role of corporate branding in managing corporate reputation, using Novo Nordisk as a case study, presents three perspectives on corporate branding: the marketing perspective, the organisational perspective and the co......-creation perspective. The three perspectives reviewed show the possibility of developing a multidisciplinary conceptualisation of corporate branding. They all offer insights important to managing organisations as corporate brands in a multi-stakeholder context and thus to the likelihood that corporate branding...... is a way to influence corporate reputation. The Novo Nordisk management believes the data indicate that corporate branding influenced reputation more than the other way around. Formal brand management practices may work considerably better when they complement rather than try to control existing forces...

  6. Managing Corporate Reputation Through Corporate Branding

    DEFF Research Database (Denmark)

    Schultz, Majken; Hatch, Mary Jo; Adams, Nick

    2012-01-01

    -creation perspective. The three perspectives reviewed show the possibility of developing a multidisciplinary conceptualisation of corporate branding. They all offer insights important to managing organisations as corporate brands in a multi-stakeholder context and thus to the likelihood that corporate branding......This article, which concentrates on symbolic management by explaining the role of corporate branding in managing corporate reputation, using Novo Nordisk as a case study, presents three perspectives on corporate branding: the marketing perspective, the organisational perspective and the co...... is a way to influence corporate reputation. The Novo Nordisk management believes the data indicate that corporate branding influenced reputation more than the other way around. Formal brand management practices may work considerably better when they complement rather than try to control existing forces...

  7. Advanced turbine technology applications program, (ATTAP): An overview of complementary activities on ceramic materials within the Allied-Signal Corporation and the General Motors Corporation which provide synergistic benefits to the ATTAP program, 1988--1992

    Energy Technology Data Exchange (ETDEWEB)

    1989-04-01

    A significant level of Research and Development and product development activities on ceramic materials is being carried on by the General Motors Corporation and the Allied-Signal Corporation, the parent companies of the ATTAP contractors, Allison Gas Turbine Division and Garrett Auxiliary Power Division, respectively. In continuing the automotive gas turbine program with both Allison and Garrett in the application of high temperature structural materials in advanced automotive gas turbine engines it was the intention of the Department of Energy to not only provide encouragement to these companies to continue their activities on ceramic materials which are providing important synergistic benefits to ATTAP but also to signal the developing US ceramics industry of a continuing commitment to this program by important elements of the gas turbine industry and the automotive industry. 5 figs.

  8. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

    Directory of Open Access Journals (Sweden)

    Asier González

    Full Text Available Ptc6 is one of the seven components (Ptc1-Ptc7 of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+. Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.

  9. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Science.gov (United States)

    2010-10-01

    ... Third-Party Assessment of PTC System Safety Verification and Validation F Appendix F to Part 236... F to Part 236—Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System... independent third-party assessment of PTC system safety verification and validation pursuant to subpart H or I...

  10. Corporate governance in a networked age

    NARCIS (Netherlands)

    Vermeulen, Erik

    2015-01-01

    In a networked and digital age, we need to rethink the structure of the modern corporation. In order to survive and grow, corporations must operate with a new set of assumptions and principles in order to remain relevant, competitive, and successful. Consider the growing number of technology startup

  11. Corporate Social Communication and Corporate Social Performance

    OpenAIRE

    Ziggers, Gerrit Willem

    2013-01-01

    The purpose of this paper is to provide firms in the food and agricultural sector a model that enables them to assess their corporate social initiatives in conjunction with their stakeholders. Building on the concepts of corporate social responsibility (CSR), corporate social performance (CSP) and the relational view the paper argues that firms can improve the results of their corporate social initiatives by setting up a dialogue with their stakeholders and to relate this to their internal or...

  12. Water Stewardship and Corporate Sustainability

    Directory of Open Access Journals (Sweden)

    Peter JONES

    2014-12-01

    Full Text Available The aim of this paper is to provide an exploratory review of the extent to which some of the world’s leading companies are publicly addressing water stewardship as part of their corporate sustainability strategies. The paper begins with an outline of the growing importance of corporate sustainability and water stewardship. The paper draws its empirical material from the most recent information on sustainability posted on the top twelve ‘Consumer Superbrands’ corporate websites. The findings reveal that a majority of the selected companies address a number of elements concerning water stewardship as part of their more general approach to corporate sustainability. However corporate commitments to water stewardship can be interpreted as being driven as much by business imperatives as by any concerns for environmental sustainability or a desire to maintain the viability and integrity of natural ecosystems. More critically the authors suggest that the selected companies’ commitments to water stewardship are framed within existing business models focused on technological improvements in eco-efficiency and continuing economic growth. The paper provides an accessible review of the water stewardship issues being pursued by some of the world’s leading companies and as such it will interest academics, students, political commentators and business managers interested in water stewardship and corporate sustainability.

  13. The use of PTC and RFA as treatment alternatives with low procedural morbidity in non-small cell lung cancer.

    Science.gov (United States)

    Choe, Yeong Hun; Kim, So Ri; Lee, Kyung Sun; Lee, Ka Young; Park, Seoung Ju; Jin, Gong Yong; Lee, Yong Chul

    2009-07-01

    Minimally invasive percutaneous ablative therapies for treating lung cancers are currently being studied as treatment alternatives. This present study investigated the efficacies of percutaneous thoracic cryotherapy (PTC) and radiofrequency ablation (RFA) on clinical courses of pulmonary malignant tumours, especially in the setting of non-surgical candidates. Sixty-five patients with lung malignancy underwent sixty-seven sessions of RFA and nine sessions of PTC. We evaluated the results of RFA and PTC including efficacies, local progression rate, survival rate, and complications. Twenty-nine patients (43.3%) treated with RFA and six patients (66.7%) with PTC attained complete ablation. In small-sized lung mass (3 cm), complete ablation rate of RFA and PTC was increased to 76.2% and 85.7%, respectively. Additionally, we have found that the complete ablation group had significantly higher survival duration and progression free survival duration compared with the partial ablation group. Moreover, the complication profile was acceptable and the pain associated with the procedures disappeared within 1 day; 42 patients (62.7%) after RFA and all patients after PTC. This study provides evidence for the use of PTC and RFA as treatment alternatives with low procedural morbidity in the management of inoperable pulmonary malignant tumours, although the current study is limited by the small sample size and the short follow-up period.

  14. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells.

    Science.gov (United States)

    Mayr, Christian; Wagner, Andrej; Loeffelberger, Magdalena; Bruckner, Daniela; Jakab, Martin; Berr, Frieder; Di Fazio, Pietro; Ocker, Matthias; Neureiter, Daniel; Pichler, Martin; Kiesslich, Tobias

    2016-01-05

    BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and is up-regulated in biliary tract cancer (BTC), contributing to aggressive clinical features. In this study we investigated the cytotoxic effects of PTC-209, a recently developed inhibitor of BMI1, in BTC cells. PTC-209 reduced overall viability in BTC cell lines in a dose-dependent fashion (0.04 - 20 µM). Treatment with PTC-209 led to slightly enhanced caspase activity and stop of cell proliferation. Cell cycle analysis revealed that PTC-209 caused cell cycle arrest at the G1/S checkpoint. A comprehensive investigation of expression changes of cell cycle-related genes showed that PTC-209 caused significant down-regulation of cell cycle-promoting genes as well as of genes that contribute to DNA synthesis initiation and DNA repair, respectively. This was accompanied by significantly elevated mRNA levels of cell cycle inhibitors. In addition, PTC-209 reduced sphere formation and, in a cell line-dependent manner, aldehyde dehydrogease-1 positive cells. We conclude that PTC-209 might be a promising drug for future in vitro and in vivo studies in BTC.

  15. ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells

    Directory of Open Access Journals (Sweden)

    Aherne Sinead

    2008-05-01

    Full Text Available Abstract Background Hashimoto Thyroiditis (H.T. is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD and thyroid neoplasia. The purpose of this study was to observe the immunogenic effect exposure to H.T. and control lymphocyte supernatant would have on normal (Nthy-ori and ret/PTC-1 (TPC-1 expressing thyroid cell line models. Results A 2 × 2 matrix comprising Nthy-ori and TPC-1 cell lines and H.T. and control lymphocyte supernatant was designed and utilised as follows; activated lymphocytic supernatant from a H.T. and normal control were co-cultured with a cell line derived from normal thyroid (Nthy-ori and also a cell line derived from a papillary thyroid carcinoma that endogenously expresses ret/PTC-1 (TPC-1. The co-cultures were harvested at 0, 6 and 18 hour time points. Gene expression analysis was performed on RNA extracted from thyrocytes using TaqMan® Immune profiling Low-Density Arrays (Applied Biosystems, CA, USA comprising gene expression markers for 93 immune related targets plus 3 endogenous controls. Stimulation of the normal thyroid cell line model with activated T cell supernatant from the H.T. donor yielded global up-regulation of immune targets when compared with control supernatant stimulation. In particular, a cohort of targets (granzyme B, CD3, CD25, CD152, CD45 associated with cytotoxic cell death; T cell receptor (TCR and T cell signaling were up-regulated in the normal cell line model. When the ret/PTC-1 expressing thyroid cell line was co-cultured with H.T. lymphocyte supernatant, in comparison to control supernatant stimulation, down-regulation of the same subset of immune targets was seen. Conclusion Co-culturing H.T. lymphocyte supernatant with a normal thyroid cell line model leads to over-expression of a subset of targets which could contribute to the pathogenesis of H

  16. [The correlation between BRAF mutations, RET/PTC rearrangements and platelet-derived growth factor B expression in papillary thyroid carcinomas].

    Science.gov (United States)

    Wang, Ping; Wang, Yan-gang; Zhao, Wen-juan; Fu, Yu-dong; Wang, Luan; Wang, Fang; Zhao, Shi-hua

    2012-12-01

    To investigate the prevalence of BRAF T1799A mutation and RET/PTC rearrangement in Qingdao and detect the expression of platelet-derived growth factor B (PDGF-B) in order to investigate the correlation between gene mutation and PDGF-B. Fresh tissue from 48 papillary thyroid carcinomas (PTC) patients was examined for BRAF mutation RET rearrangements (RET/PTC1 and RET/PTC3) by PCR, followed by direct-sequence analysis. The expression of PDGF was analyzed by immunohistochemistry. Among the 48 patients, 14 (29.2%) were micro PTC; 18 (37.5%) had BRAF T1799A mutations and 23(47.9%) had RET/PTC rearrangement. There were 17 (35.4%) cases of RET/PTC1 and 6 (12.5%) of RET/PTC3, with no multiple rearrangements. Both BRAF T1799A mutation and RET/PTC rearrangement were present in 6 (12.5%) cases of non-micro PTC. The level of PDGF-B expression in BRAF T1799A positive was higher than that in the negative, and the level of PDGF-B expression in RET/PTC3 was higher than that in RET/PTC1 (P PTC rearrangement is higher in Qingdao. BRAF T1799A mutation and RET/PTC3 rearrangement in patients suggests a poorer prognosis than the negative one. The BRAF T1799A mutation and RET/PTC3 rearrangement may strengthen the expression of PDGF-B. Both variations suggest a poor prognosis.

  17. HDPE/EPDM/CB复合物的PTC效应%PTC Effect in HDPE/EPDM/CB Composites

    Institute of Scientific and Technical Information of China (English)

    赫秀娟; 陈欣方; 王丽杰; 刘志城

    2001-01-01

    Polymer positive temperature coefficient(PTC) material comprising conductive particles,e.g.carbon black (CB),dispersed in polymer matrix is suitable for use as electrical devices such as circuit overcurrent protection device,self-regulation heaters,sensors,etc..In this paper,the PTC effect of carbon black filled polyethylene and ethylene-propylene-diene terpolymer blends was studied.Effects of raw material ratio and type of carbon black were investigated.The distribution of CB in polymer matrix and the function of crystallites on PTC effect were discussed.

  18. 上市公司的科技投入对公司绩效的贡献度研究%Research on the Contribution of Science and Technology Investment to Company Performance of Listing Corporation

    Institute of Scientific and Technical Information of China (English)

    罗声明

    2014-01-01

    科技创新是经济发展、社会进步的动力源泉,坚定发展自主创新是我国上市公司提高核心竞争能力的必由之路。本文以科学地评价科技投入对我国上市公司绩效的贡献度为核心研究内容,遴选了 R&D 科技投入和其它科技投入及其派生指标作为科技投入的表征变量,遴选了产品销售收入、净利润、净资产收益率、每股收益率及其增长率作为公司绩效的表征变量,并通过相关分析和回归分析展开了实证分析。实证分析的结论表明,科技投入和我国上市公司绩效之间存在一定的关联,但影响作用并不明显。针对这一实际问题,本文给出了相应的政策建议,以期让科技投入更好地促进上市公司绩效的提升。%Technology innovation is the source of economic development and social progress . Independent innovation is the route which can improve the core competition ability of listing corporation .In this paper ,the contribution of science and technology investment was researched for company performance of listing corporation . R&D investment and other investment have been selected as the variables which can express science and technology investment ,and four variables are also selected to express company performance of listing corpo-ration such as product sales revenue ,net profit , return on net assets ,and earnings per share .Empirical analysis show that there is a cer-tain correlation between science and technology investment and listing corporation performance ,but the effect is not obvious .According to this problem , corresponding policy recommendations have been given in order to make science and technology investment to better promote the listing corporation performance .

  19. The Corporate Secretary

    OpenAIRE

    International Finance Corporation

    2016-01-01

    This Handbook offers a concise and practical description of how corporate secretaries might carry out their role to improve governance in their organizations. It can also serve as a guidance tool for both International Finance Corporation (IFC) clients and advisory staff to clarify the potentially expansive duties of corporate secretaries and to help them assist corporate secretaries in un...

  20. Information and Corporate Cultures.

    Science.gov (United States)

    Drake, Miriam A.

    1984-01-01

    This paper defines "corporate culture" (set of values and beliefs shared by people working in an organization which represents employees' collective judgments about future) and discusses importance of corporate culture, nature of corporate cultures in business and academia, and role of information in shaping present and future corporate cultures.…

  1. Realizing Corporate Responsibility

    DEFF Research Database (Denmark)

    Girschik, Verena

    This doctoral dissertation aims to understand how companies realize corporate responsibility - both how they perform corporate responsibility in particular local contexts and how they negotiate understandings of what corporate responsibility means. It builds on an inductive case study of the Danish...... in this dissertation unfold distinct yet interdependent processes of positioning and framing that constitute new ways of performing and understanding corporate responsibility....

  2. Electrochemical characterisation of Pt/C suspensions for the reduction of oxygen

    Energy Technology Data Exchange (ETDEWEB)

    Benitez, R.; Chaparro, A.M.; Daza, L. [Dep. Combustibles Fosiles, CIEMAT, Av. Complutense, 22, 28040 Madrid (Spain)

    2005-10-10

    Electrodes based on carbon-supported platinum electrocatalysts (Pt/C) have been studied in aqueous electrolyte electrochemical cells. The electrodes are prepared from suspensions of commercial Pt/C catalyst, deposited onto a carbon-covered Pt disk. Three deposition methods have been used, impregnation, spray and electrospray. The utilisation of Pt, i.e. the amount of Pt that really participates in the electrochemical reaction, was determined for each preparation method from measurements of the mass of Pt deposited on the electrode, and of the electroactive area of Pt. Higher utilisation rates are found on electrodes prepared by the impregnation method. The activity towards oxygen reduction in aqueous electrolyte was studied with the rotating electrode at different temperatures. (author)

  3. A PTC Optimization and Control Surface Interference Study HSR Airframe Technical Review

    Science.gov (United States)

    Hicks, Raymond; Cliff, Susan; Rimlinger, Mark; Murman, Scott; Reuther, James

    1999-01-01

    This report considers the effect of canard and horizontal tail vertical position on the aerodynamic characteristics of the PTC configuration without nacelles and diverters. This analysis is followed by three optimization studies using canard and tail incidence as design variables in the first problem followed by an optimization run with canard and tail incidence and wing camber design variables and finally an optimization run with canard incidence and wing camber. The first problem was run at fixed lift while the other two problems were run at fixed angle of attack. The final investigation reported here will show data from a component buildup study using the PTC configuration. This final study will show the aerodynamic interference between the canard, wing and horizontal tail.

  4. Ultrasound assisted PTC catalyzed saponification of vegetable oils using aqueous alkali.

    Science.gov (United States)

    Bhatkhande, B S; Samant, S D

    1998-03-01

    A few vegetable oils were saponified using aqueous KOH and different PTCs at room temperature in the presence of ultrasound. The extent of saponification was studied using the saponification value as a reference. Optimizations of various parameters such as time, selection of PTC, quantity of PTC, quantity of KOH and quantity of water were carried out using soyabean oil as a sample oil under sonication with stirring. To study the effect of ultrasound, the saponification was also carried out at 35 +/- 2 degrees C under different conditions, namely stirring, sonication, stirring and sonication, and heating at 100 degrees C. It was found that the heterogeneous liquid-liquid phase saponification of different vegetable oils using aq. KOH/CTAB was remarkably accelerated at 35 +/- 2 degrees C in the presence of ultrasound along with stirring.

  5. Fabrication and Characterization of High-activity Pt/C Electrocatalysts for Oxygen Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Borami; Kim, Joung Woon; Hwang, Seung Jun; Yoo, Sung Jong; Cho, Eun Ae; Lim, Tae Hoon; Kim, Soo Kil [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

    2010-06-15

    A 20 wt % Pt/C is fabricated and characterized for use as the cathode catalyst in a polymer electrolyte membrane fuel cell (PEMFC). By using the polyol method, the fabrication process is optimized by modifying the carbon addition sequence and precursor mixing conditions. The crystallographic structure, particle size, dispersion, and activity toward oxygen reduction of the as-prepared catalysts are compared with those of commercial Pt/C catalysts. The most effective catalyst is obtained by ultrasonic treatment of ethylene glycol-carbon mixture and immediate mixing of this mixture with a Pt precursor at the beginning of the synthesis. The catalyst exhibits very uniform particle size distribution without agglomeration. The mass activities of the as-prepared catalyst are 13.4 mA/mgPt and 51.0 mA/mgPt at 0.9 V and 0.85 V, respectively, which are about 1.7 times higher than those of commercial catalysts.

  6. Whether the Information Investment can Improve the Technology Efficiency of Industrial Listing Corporation%信息技术投资是否提高了工业上市公司的技术效率?

    Institute of Scientific and Technical Information of China (English)

    刘飞

    2014-01-01

    This paper analyzes the impact of information technology investments on its technical efficiency of China's Industrial List-ing Corporation between 2000 and 2012 . The panel Stochastic Frontier (PSFA) models and the translog production function , are used to calculated the technical efficiency of listing corporation . Moreover , it analyzed the influence factors of information technology investment on technical efficiency by Panel Data model . Results indicate that information technology investment are not to enhance the efficiency of Indus-trial Listing Corporation . However , enterprise governance , scale , industry , regional and other factors can significantly affect the efficien-cy of technology . This shows that China's Industrial Listing Corporation may be excessive investment in information technology , or did not play its role through effective management . Therefore , at the micro level , the integration of informatization and industrialization is not in-creasing investment in information technology , but to improve the management level , give full play to the role of information technology in-vestment .%本文分析了我国工业上市公司2000~2012年间信息技术投资对其技术效率的影响。采用面板随机前沿(PSFA )模型,通过超越对数生产函数,计算了上市公司的技术效率,并用面板数据模型分析了信息技术投资等因素对技术效率的影响。结果发现信息技术投资并没有给工业上市公司带来效率提升,而企业公司治理、规模、行业、地域等因素却对技术效率具有显著的影响。这说明我国工业上市公司可能存在信息技术投资过度,或者没有通过有效地管理发挥其作用。因此,在微观层面上,信息化与工业化融合并不是不断增加信息技术投资,而是要提高管理水平,充分发挥信息技术投资的作用。

  7. Technological change and corporate governance

    OpenAIRE

    Brockoff, Klaus

    2005-01-01

    Texto en inglés. Abstract en español e inglés. Los sistemas configuradores del "Gobierno Corporativo" de las empresas constituyen, sin duda, un elemento de competítividad empresarial y entre países ya que viene determinado por la legislación de cada país. Brockhoff plantea en este trabajo la grave interreladón entre el espacio que facilita las normativas reguladoras del "Gobierno de la corporación" y las exigencias de poder adaptarse estratégicamente a los cambios tecnológicos. La falta...

  8. Materials for damping the PTC-induced thermal fluctuations of the cold-head

    Science.gov (United States)

    Catarino, I.; Martins, D.; Sudiwala, R.

    2015-12-01

    The cold head on mechanical Pulse Tube Cryocoolers (PTCs) is subject to substantially less mechanical vibration and electromagnetic interference compared to that typically found in Gifford MacMahon coolers. However, thermal fluctuations at the PTC frequency are still present at the cold-head, typically at a level of 200 mK peak-to-peak at 1.4 Hz for a Cryomech Model PT405 cooler running at 4 K. It is highly desirable to damp out these fluctuations if PTCs are to be used successfully for running systems sensitive to such thermal fluctuations, for example, bolometeric detectors. We report here the characterization over the temperature range 2.5 K to 6 K of two materials, GOS (Gd2O2S) and GAP (GdAlO3), for use as low-pass thermal filters. These materials have antiferromagnetic transitions at around 4 K giving rise to an enhanced heat capacity and have a high thermal conductance. These are two highly desirable properties for thermal dampers in this application. Those materials were fired as ceramic discs to be tested as thermal dumpers. Thermal filter assemblies with discs of diameter 75 mm and thickness 2.5 mm and 1.6 mm (GOS and GAP, respectively) mounted in a PTC show thermal attenuation levels of x0.12 (GOS) and x0.11 (GAP) at 0.01Hz with a clean-side temperature of 4 K; the PTC induced fluctuations at 1.48 Hz are damped completely to within the noise limits (0.2 mK) of the thermometers. Experimentally determined thermal conductance and heat capacity data are reported. For this system, with a PTC cold-head (dirty-side) temperature of 3.3 K, a clean-side power dissipation of up to 30 mW is realized before its temperature rises above 4.2 K.

  9. RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.

    Science.gov (United States)

    Qiu, Jie; Zhang, Wenwei; Xia, Qingsheng; Liu, Fuxue; Li, Li; Zhao, Shuwei; Gao, Xian; Zang, Chuanshan; Ge, Ruifeng; Sun, Yan

    2016-02-01

    The study aims to uncover molecular mechanisms of PTC (papillary thyroid carcinoma) progression and provide therapeutic biomarkers. The paired tumor and control tissues were obtained from 5 PTC patients. RNA was extracted and cDNA libraries were constructed. RNA-sequencing (RNA-seq) was performed on the Illumina HiSeq2000 platform using paired-end method. After preprocessing of the RNA-seq data, gene expression value was calculated by RPKM. Then the differentially expressed genes (DEGs) were identified with edgeR. Functional enrichment and protein-protein interaction (PPI) network analyses were conducted for the DEGs. Module analysis of the PPI network was also performed. Transcription factors (TFs) of DEGs were predicted. A cohort of 496 up-regulated DEGs mainly correlating with the ECM degradation pathways, and 440 down-regulated DEGs predominantly enriching in transmembrane transport process were identified. Hub nodes in the PPI network were RRM2 and a set of collagens (COL1A1, COL3A1 and COL5A1), which were also remarkable in module 3 and module 5, respectively. Genes in module 3 were associated with cell cycle pathways, while in module 5 were related to ECM degradation pathways. PLAU, PSG1 and EGR2 were the crucial TFs with higher transcriptional activity in PTC than in control. Several genes including COL1A1, COL3A1, RRM2, PLAU, and EGR2 might be used as biomarkers of PTC therapy. Among them, COL1A1 and COL3A1 might exert their functions via involving in ECM degradation pathway, while RRM2 through cell cycle pathway. PLAU might be an active TF, whereas EGR2 might be a tumor suppressor. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Electrochemical Behavior of Mitoxantrone and Its Determination at a Pt/C Implanted Modified Microelectrode

    Institute of Scientific and Technical Information of China (English)

    QIAN Yong-gui; SUN Zi-jie; HU Jing-bo; LU Yi-qiang; LI Qi-long

    2004-01-01

    In a 0.02 mol/L Na2HPO4-KH2PO4(PBS) buffer solution(pH=6.82), the electrochemical behavior of mitoxantrone was studied by linear-sweep voltammetry and cyclic voltammetry at a Pt/C ion implantation modified microelectrode. A sensitive reduction peak was observed. The peak potential was -0.72 V(vs.SCE), the peak current was proportional to the concentration of mitoxantrone within the ranges of 7.0×10-8-9.0×10-7 mol/L and 1.0×10-6-2.4×10-5 mol/L, with a detection limit of 4.0×10-8 mol/L. The linear correlation coefficients were 0.9994 and 0.9992, respectively. This method has been applied to the direct determination of mitoxantrone in simulated urine. The recoveries were in the range from 96.2% to 105.9%. The reduction process was a quasi-reversible one with adsorptive characteristics at the Pt/C microelectrode. The electrode reaction rate constant ks and the electron transfer coefficient α of the system were determined to be 4.5 and 0.65 s-1, respectively. The experiments showed that Pt element had surely been implanted into the surface of the carbon fiber, and the atomic Pt improved the electrocatalytic activity. The Pt/C microelectrode had a good stability and reproducibility.

  11. Polyol synthesis of nanosized Pt/C electrocatalysts assisted by pulse microwave activation

    Energy Technology Data Exchange (ETDEWEB)

    Lebegue, E.; Baranton, S.; Coutanceau, C. [Laboratoire de Catalyse en Chimie Organique (LACCO), UMR 6503 CNRS, Universite de Poitiers, 40 av recteur Pineau, F-86000 Poitiers (France)

    2011-02-01

    A polyol process assisted by pulse microwave activation was used to prepare efficient Pt/C electrocatalysts for PEMFC applications with reducing cost. Catalysts from pulsed microwave method were compared with a catalyst issued from a classical method, in terms of active surface area, platinum loading and activity towards the oxygen reduction reaction. A design of experiments (DOE derived from the Taguchi method) has been implemented to optimize experimental parameters only related to pulse microwave activation, the intrinsic synthesis parameters (concentration of platinum salt, platinum/carbon weight ratio and pH) being kept constant. Controlled parameters were duration of microwave pulse, maximum temperature and total duration of the synthesis. Considered responses were catalyst active surface area and the Pt/C loading. An optimized configuration of synthesis parameter was proposed. The confirmation experiment revealed a trend in agreement with that expected. Three catalysts (two from pulsed microwave synthesis method and one prepared by the classical method) were characterized by transmission electron microscopy, cyclic voltammetry and CO stripping. Catalysts from pulsed microwave method display higher characteristics than the one prepared by the classical method. The Pt/C catalyst from the confirmation experiment displays the highest catalytic activity toward oxygen reduction reaction. (author)

  12. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis

    DEFF Research Database (Denmark)

    Wirtschafter, A; Schmidt, R; Rosen, D

    1997-01-01

    -polymerase chain reaction (RT-PCR) assay, we found messenger RNA (mRNA) expression for the RET/PTC1 and RET/PTC3 oncogenes in 95% of the Hashimoto's patients studied. All Hashimoto's patients presenting without histopathologic evidence of papillary thyroid cancer showed molecular genetic evidence of cancer......Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology. Patients afflicted with Hashimoto's have a higher risk of thyroid malignancies such as papillary thyroid carcinoma. In the present study, we investigated the frequency of papillary thyroid carcinoma...... specific genes in patients diagnosed with Hashimoto's disease. The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells. Using a sensitive and specific reverse transcriptase...

  13. PAX8/PPARG and RET/PTC rearrangement detection is feasible in routine air dried fine needle aspiration (FNA) smears

    DEFF Research Database (Denmark)

    Ferraz, Carolina; Rehfeld, Christian; Krogdahl, Annelise;

    2012-01-01

    Background: The diagnostic limitations of fine needle aspiration (FNA), like the "indeterminate" category, can be partially overcome by molecular analysis. As PAX8/PPARG and RET/PTC rearrangements have been detected in follicular carcinomas (FTC) and papillary carcinomas (PTC), their detection...... as generally not suitable for testing these rearrangements in a clinical setting. Therefore, the objective of the present study was to investigate the feasibility of extracting RNA from routine-air-dried FNA smears for the detection of these rearrangements with RT-PCR. Methods: A new method for RNA extraction......). Similarly, RET/PTC was found in 3 of 96 FFPEs and in 4 of 96 FNAs. Two of 21 PTC samples and 3 of 42 FA samples carried this rearrangement. Conclusion: These data are the first to show the feasibility of extracting RNA from routine air dried FNA smears for the detection of PAX8/PPARG and RET...

  14. Quantitative shear wave elastography as a prognostic implication of papillary thyroid carcinoma (PTC): elasticity index can predict extrathyroidal extension (ETE).

    Science.gov (United States)

    Park, Yun Joo; Kim, Jeong-Ah; Son, Eun Ju; Youk, Ji Hyun; Park, Cheong Soo

    2013-08-01

    To investigate whether the quantitative elasticity index of shear wave elastography (SWE) can predict extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) preoperatively. A total of 208 patients with pathology confirmed PTC whom underwent SWE during preoperative staging US between April 2011 to June 2012 were included.SWE indices of E mean, E max, E min of the index malignancy, the ratios between E mean of the lesion and parenchyma (E ratio-P), and muscle (E ratio-M), and grayscale US findings, including ETE, multifocality, bilaterality, and central and lateral lymph node (LN) metastasis were evaluated. The correlations of SWE indices and grayscale US findings with pathologic prognostic factors of PTC were analyzed by Chi square or Fisher's exact test, and multivariate regression analysis. ETE was associated with E mean, E max, E min, and E ratio-M (P = 0.005, 0.009, 0.016 and PTC.

  15. Corporate Social Responsibility: Consumer Behavior, Corporate Strategy, and Public Policy

    National Research Council Canada - National Science Library

    Kreng, Victor B; Huang, May-Yao

    2011-01-01

    ... as "the consumers' impression of the corporation itself, corporate product marketing, and the services provided by the corporation". Corporate image is thus the consumers' subjective overall assessment of the corporation. Some marketing experts believe that the role corporations play in the wider society will help build their corporate image. ...

  16. Comparison of C4d detection on erythrocytes and PTC-C4d to histological signs of antibody-mediated rejection in kidney transplantation.

    Science.gov (United States)

    Haidar, F; Kisserli, A; Tabary, T; McGregor, B; Noel, L H; Réveil, B; Toupance, O; Rieu, P; Thervet, E; Legendre, C; Morelon, E; Issa, N; Cohen, J H M

    2012-06-01

    C4d on erythrocytes (EC4d), C4d peritubular capillary deposition (PTC-C4d) staining and histology were compared in a cross-sectional cohort of 146 renal allograft biopsies (132 patients). EC4d levels paralleled PTC-C4d staining, but were more predictive of peritubular capillaritis (PTC). Donor-specific antibodies (DSA), PTC-C4d, EC4d and PTC were analyzed in an independent longitudinal follow-up cohort (96 biopsies, 76 patients). Seventy-six samples were PTC and EC4d concordant, 11 positive and 65 negative, 7 PTC-EC4d+ and 13 PTC+EC4d-. EC4d levels were related to DSA occurrence. With ABMR defined by PTC and DSA, all apparently discordant patients, EC4d negative, were correctly reassigned comparing EC4d level curves with rejection kinetics, with positive EC4d samples predating biopsy or late biopsies compared with ABMR flare-ups. All EC4d-positive patients without PTC or DSA had permanent high EC4d levels unrelated to rejection. EC4d was more abundant in PTC-positive (mean = 108.5%± 3.4; n = 50) than PTC-negative samples (mean = 88.1%± 1.3; n= 96; p PTC-C4d and EC4d for PTC were, respectively, 75%, 79%; 64%, 76% (p < 0.05); 28%, 46% (p < 0.05) and 93%, 94%. Values were similar for DSA. A noninvasive blood test, EC4d, and particularly longitudinally monitoring EC4d levels, may increase surrogate ABMR testing options. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

  17. IS and Organization for Online Corporate Reputation Management

    OpenAIRE

    Alberto Francesconi; Claudia Dossena

    2012-01-01

    According to the Resource Based View, corporate reputation is seen as a core resource and a major factor in gaining competitive advantage. Thanks to the development of Web-based technologies, stakeholders can easily spread their own perspective about an organization, its products, services, brands, members, and so forth, affecting its corporate reputation. This work examines the Web side of corporate reputation conceptualized as ‘online corporate reputation’ and the exploitation of IT (On...

  18. A type 2C protein phosphatase FgPtc3 is involved in cell wall integrity, lipid metabolism, and virulence in Fusarium graminearum.

    Directory of Open Access Journals (Sweden)

    Jinhua Jiang

    Full Text Available Type 2C protein phosphatases (PP2Cs play important roles in regulating many biological processes in eukaryotes. Currently, little is known about functions of PP2Cs in filamentous fungi. The causal agent of wheat head blight, Fusarium graminearum, contains seven putative PP2C genes, FgPTC1, -3, -5, -5R, -6, -7 and -7R. In order to investigate roles of these PP2Cs, we constructed deletion mutants for all seven PP2C genes in this study. The FgPTC3 deletion mutant (ΔFgPtc3-8 exhibited reduced aerial hyphae formation and deoxynivalenol (DON production, but increased production of conidia. The mutant showed increased resistance to osmotic stress and cell wall-damaging agents on potato dextrose agar plates. Pathogencity assays showed that ΔFgPtc3-8 is unable to infect flowering wheat head. All of the defects were restored when ΔFgPtc3-8 was complemented with the wild-type FgPTC3 gene. Additionally, the FgPTC3 partially rescued growth defect of a yeast PTC1 deletion mutant under various stress conditions. Ultrastructural and histochemical analyses showed that conidia of ΔFgPtc3-8 contained an unusually high number of large lipid droplets. Furthermore, the mutant accumulated a higher basal level of glycerol than the wild-type progenitor. Quantitative real-time PCR assays showed that basal expression of FgOS2, FgSLT2 and FgMKK1 in the mutant was significantly higher than that in the wild-type strain. Serial analysis of gene expression in ΔFgPtc3-8 revealed that FgPTC3 is associated with various metabolic pathways. In contrast to the FgPTC3 mutant, the deletion mutants of FgPTC1, FgPTC5, FgPTC5R, FgPTC6, FgPTC7 or FgPTC7R did not show aberrant phenotypic features when grown on PDA medium or inoculated on wheat head. These results indicate FgPtc3 is the key PP2C that plays a critical role in a variety of cellular and biological functions, including cell wall integrity, lipid and secondary metabolisms, and virulence in F. graminearum.

  19. [RET/PTC Gene Rearrangements in the Sporadic and Radiogenic Thyroid Tumors: Molecular Genetics, Radiobiology and Molecular Epidemiology].

    Science.gov (United States)

    Ushenkova, L N; Koterov, A N; Biryukov, A P

    2015-01-01

    A review of molecular genetic, radiobiological and molecular epidemiological studies of gene (chromosome) rearrangements RET/PTC in the cells of the thyroid gland as well as the laws in relation to radiation exposure in vitro, in vivo and human populations identified with them are submitted. The data on the c-RET gene and its chimeric constructs with the gene-donors (RET/PTC rearrangements) are considered. The information about the history of the RET/PTC discovery, their types, carcinogenic potential and specificity both to tumor and non-tumor thyroid disease especially for papillary thyroid carcinoma are provided. The data (seven studies) on the induction of RET/PTC after irradiation of tumor and normal thyroid cells in vitro and mice are reviewed. The mechanisms of RET/PTC induction may be associated with DNA double strand breaks and oxidative stress. Some information (three publications) about the possibility of RET/PTC induction by low doses of radiation with low LET (to 0.1 Gy) is given and it is concluded that their potential evidentiary is generally weak. The achievements in the molecular epidemiology of RET/PTC frequency for exposed and unexposed cohorts are stated. At the same time it is noted that, despite the vast array. of data accumulated from 30 countries of the world and more than 20 years of research, the formed provisions are weakly confirmed statistically and have no base corresponding to the canons of evidence-based medicine. The possibility of use of the RET/PTC presence or their frequencies as markers of the papillary thyroid carcinomas and, specifically, their radiogenic forms, is considered. In the first case the answer may be positive, while in the second, the situation is characterized by uncertainty. Based to the above mentioned we came to a conclusion about the need of a pooled or meta-analysis of the totality of the published data.

  20. Concomitant BRAF(V600E) mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma.

    Science.gov (United States)

    Guerra, Anna; Zeppa, Pio; Bifulco, Maurizio; Vitale, Mario

    2014-02-01

    The tyrosine kinase receptors/RAS/RAF/MAPK cascade is a site of mutational events associated with thyroid carcinogenesis. Some studies suggest the reciprocal exclusion of different oncogenes in the mitogen-activated protein kinase cascade, whereas others suggest that BRAF mutations and RET rearrangements can simultaneously occur in sporadic cases. The aim of this study was to determine the prevalence of concomitant BRAF(V600E) mutation and RET/PTC rearrangements in the same tumor and its association with some clinicopathological features. The percentage of mutant BRAF alleles and the presence of RET/PTC rearrangements were determined by means of pyrosequencing and Southern blot analysis of reverse transcription polymerase chain reaction products in a series of 72 conventional papillary thyroid carcinomas (PTCs). Then, the associations between clinicopathological characteristics and mutation status were assessed. BRAF(V600E) alleles were present in 32 out of 72 PTCs (44.4%) in the range of 5.1-44.7% of total BRAF alleles. RET/PTC was present in 26 tumors (36.1%). Concomitant subclonal BRAF and RET/PTC were demonstrated in 14 PTCs (19.4%), and none of the oncogenes was detected in 22 tumors (30.5%). Only BRAF(V600E) was associated with a more advanced tumor staging. The present study demonstrates that concomitant BRAF mutation and RET/PTC rearrangement is a frequent event in PTC.

  1. Corporate governance and government owned corporations in Queensland

    National Research Council Canada - National Science Library

    MCDONOUGH, Darryl D

    1998-01-01

    ...) - principles of corporate governance applicable to government owned corporations - history of corporatisation - objectives and features of the Government Owned Corporations Act 1993 - categorisation...

  2. Corporate communications and stakeholder management

    Directory of Open Access Journals (Sweden)

    Đorđević Mira

    2010-01-01

    Full Text Available Corporate communications represent a modern communications discipline used by businesses across the globe to communicate with key stakeholders. Chief executive officers and executive management teams strive to create, protect and advance corporate reputation through corporate communications. Further, by communicating with key stakeholders the company adequately prepares for good news and future problems. With the benefit of technology and greater transparency, corporations of the future will continue to use corporate communications approaches to advance their business. Company's reputation derives from the way stakeholders perceive the organization, how they think, feel or act towards it. It is therefore vital that organizations interested in developing and building their reputational capital; pay careful attention to the way they are perceived and that they manage the relationships with their various stakeholders like a strategic resource. Stakeholders represent both opportunity and threat for the organizations. For instance, if an institution has a good reputation with stakeholders they may provide the organization more latitude to operate. On the other hand a poor reputation may result in creating the legislative that can make it more difficult for an institution to operate.

  3. Corporate Bonds in Denmark

    DEFF Research Database (Denmark)

    Tell, Michael

    2015-01-01

    Corporate financing is the choice between capital generated by the corporation and capital from external investors. However, since the financial crisis shook the markets in 2007–2008, financing opportunities through the classical means of financing have decreased. As a result, corporations have...... to think in alternative ways such as issuing corporate bonds. A market for corporate bonds exists in countries such as Norway, Germany, France, the United Kingdom and the United States, while Denmark is still behind in this trend. Some large Danish corporations have instead used foreign corporate bonds...... markets. However, NASDAQ OMX has introduced the First North Bond Market in December 2012 and new regulatory framework came into place in 2014, which may contribute to a Danish based corporate bond market. The purpose of this article is to present the regulatory changes in Denmark in relation to corporate...

  4. ASME power test code ptc 4.1 for steam generators; Codigo de pruebas de potencia ASME ptc 4.1 para generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Plauchu Alcantara, Jorge Alberto [Plauchu Consultores, Morelia, Michoacan (Mexico)

    2001-07-01

    This presentation is oriented towards those who in this subject have experience in the design and equipment specification, plant projects, factory and field testing, operation or result analyses. An important fraction of the national energy supply, approximately 13%, is applied to the steam generation in the different aspects of the industrial activity, in the electrical industry of public service and in the commercial and services sector. The development of the national programs of energy efficiency verifies this when dedicating to this use of the energy important projects, some of them with support of the USAID. The measurement of the energy utilization or the efficiency of steam generators (or boilers) is made applying some procedure agreed by the parts and the one of greater acceptance and best known in Mexico and internationally is the ASME Power Test Code PTC 4.1 for Steam Generators. The purpose and formality in the determination of efficiency and of steam generation capacity behavior, thermal basic regime or fulfillment of guarantees, radically changes the exigencies of strict attachment to the PTC 4.1 This definition will determine the importance of the test method selected, the deviations and convened exceptions, the influence of the precision and the measurement errors, the consideration of auxiliary equipment, etc. An interpretation or incorrect application of the Test Code has lead and will lead to results and nonreliable decisions. [Spanish] Esta exposicion se orienta a quienes en este tema cuenta con experiencia en diseno y especificacion de equipo, proyecto de planta, pruebas en fabrica y campo, operacion o analisis de resultados. Una fraccion importante de la oferta nacional de energia, 13% aproximadamente, se aplica a la generacion de vapor en diferentes giros de actividad industrial, en la industria electrica, de servicio publico y en el sector de servicios y comercial. El desarrollo de los programas nacionales de eficiencia energetica comprueba

  5. Research on the Effects of the Corporate Social Capital on Technology Innovation Performance%企业社会资本对技术创新绩效的影响研究

    Institute of Scientific and Technical Information of China (English)

    朱霞; 路正南

    2014-01-01

    significant positive impact on technology innovation performance, absorptive capacity plays a role of incomplete intermediate variable between corporate social capital and technological innovation performance, in the large and medium-scale enterprises, the relationship among corporate social capital, absorptive capability and technological innovation performance is not significant, in the small and micro-scale enterprises, absorptive capacity does not have sign-ificant regulating effect on the corporate social capital and technological innovation performance.

  6. Concept of JINR Corporate Information System

    Science.gov (United States)

    Filozova, I. A.; Bashashin, M. V.; Korenkov, V. V.; Kuniaev, S. V.; Musulmanbekov, G.; Semenov, R. N.; Shestakova, G. V.; Strizh, T. A.; Ustenko, P. V.; Zaikina, T. N.

    2016-09-01

    The article presents the concept of JINR Corporate Information System (JINR CIS). Special attention is given to the information support of scientific researches - Current Research Information System as a part of the corporate information system. The objectives of such a system are focused on ensuring an effective implementation and research by using the modern information technology, computer technology and automation, creation, development and integration of digital resources on a common conceptual framework. The project assumes continuous system development, introduction the new information technologies to ensure the technological system relevance.

  7. RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

    Directory of Open Access Journals (Sweden)

    Giuliana Cassinelli

    2009-01-01

    Full Text Available Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma (PTC. We have previously shown that, in human primary thyrocytes, RET/PTC1 induces a transcriptional program including the MET proto-oncogene. In PTCs, β-catenin is frequently mislocated to the cytoplasm nucleus. We investigated the interplay between Ret/ptc1 signaling and Met in regulating the proinvasive phenotype and β-catenin localization in cellular models of human PTC. Here, we show that Met protein is expressed and is constitutively active in human thyrocytes exogenously expressing RET/PTC1 as well as a mutant (Y451F devoid of the main Ret/ptc1 multidocking site. Both in transformed thyrocytes and in the human PTC cell line TPC-1, Ret/ptc1-Y451-dependent signaling and Met cooperated to promote a proinvasive phenotype. Accordingly, gene/functional silencing of either RET/PTC1 or MET abrogated early branching morphogenesis in TPC-1 cells. The same effect was obtained by blocking the common downstream effector Akt. Y451 of Ret/ptc1 was required to promote proliferation and nuclear translocation of β-catenin, suggesting that these oncogene-driven effects are Met-independent. Pharmacologic inhibition of Ret/ptc1 and Met tyrosine kinases by the multitarget small molecule RPI-1 blocked cell proliferation and invasive ability and dislocated β-catenin from the nucleus. Altogether, these results support that Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes β-catenin transcriptional activity to drive thyrocyte neoplastic transformation. Such molecular network, promoting disease initiation and acquisition of a proinvasive phenotype, highlights new options to design multitarget therapeutic strategies for PTCs.

  8. Online Privacy as a Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Pollach, Irene

    2011-01-01

    Information technology and the Internet have added a new stakeholder concern to the corporate social responsibility agenda: online privacy. While theory suggests that online privacy is a corporate social responsibility, only very few studies in the business ethics literature have connected...... these two. Based on a study of corporate social responsibility disclosures, this article contributes to the existing literature by exploring whether and how the largest IT companies embrace online privacy as a corporate social responsibility. The findings indicate that only a small proportion...... of approaches to addressing privacy was found, which suggests that no institutionalization of privacy practices has taken place yet. The study therefore indicates that online privacy is rather new on the corporate social responsibility agenda, currently playing only a minor role....

  9. Fostering Corporate Entrepreneurship

    African Journals Online (AJOL)

    ). The choice of using a strategy for corporate entrepreneurship as a primary means of .... Corporate venturing is a means of planning for organizational ambiguity in .... Multidiscipline teamwork approach, Long time horizon, Volunteer program.

  10. Corporate Consumer Contact API

    Data.gov (United States)

    General Services Administration — The data in the Corporate Consumer Contact API is based on the content you can find in the Corporate Consumer Contact listing in the Consumer Action Handbook (PDF)....

  11. Fortune 500 Corporate Headquarters

    Data.gov (United States)

    Department of Homeland Security — Large Corporate Headquarters in the United States This database is composed of 'an annual list of the 500 largest industrial corporations in the U.S., published by...

  12. High TPOAb Levels (>1300 IU/mL) Indicate Multifocal PTC in Hashimoto's Thyroiditis Patients and Support Total Thyroidectomy.

    Science.gov (United States)

    Dong, Shuai; Xia, Qing; Wu, Yi-Jun

    2015-07-01

    We aimed to identify whether thyroid peroxidase antibodies (TPOAb) are indicative of multifocal papillary thyroid cancer (PTC) in Hashimoto's thyroiditis (HT) patients and may help to determine necessity for total thyroidectomy. Retrospective cohort study. Teaching hospital. A total of 808 consecutive patients with HT alone or with HT and unifocal or multifocal PTC were included. Preoperative thyroid function tests, TPOAb determination, preoperative ultrasonography, intraoperative frozen biopsy, and postoperative routine pathologic examination to confirm thyroid nodules were performed for all patients. Patients with nodules or malignancy potential on ultrasound and fine-needle aspiration cytology were included. Patients with hyperthyroidism, concomitant chronic disease, a history of other malignant tumors, or history of major diseases were excluded. All patients underwent surgery, and HT and PTC were confirmed by postoperative pathologic results. No significant differences were found in age and sex between groups (P > .05). TPOAb ≤1300 IU/mL were more prevalent in the HT + unifocal PTC group than in the other groups (99.57% vs 15.52% and 60.75%, P 1300 IU/mL were more prevalent in the HT + multifocal PTC group than in the other groups (84.48% vs 0.43% and 39.25%; P PTC group had higher percentages of patients with elevated thyroid-stimulating hormone and positive central lymph node (LN) metastasis (elevated thyroid-stimulating hormone: 8.7% vs 3.2% and 6.5%, P = .008; positive central LN metastasis: 74.57% vs 67.38% and 0%, P 1300 IU/mL) are definitive indicators of multifocal PTC in HT patients, which may support surgical treatment with total thyroidectomy. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  13. Corporate Business Diplomacy

    DEFF Research Database (Denmark)

    Søndergaard, Mikael

    2014-01-01

    This article illustrates the interdisciplinary nature of the field of corporate business diplomacy using examples from academic disciplines, such as economics and political science, which can contribute to the understanding of corporate business diplomacy. Examples also show that corporate business...... diplomacy can complement business theories such as stakeholder theory and agency theory. Examples from practice show that in a broad sense, corporate business diplomacy is concerned with managing external stakeholders, while in a narrow sense, it is concerned with managing internal stakeholders...

  14. 25 CFR 227.6 - Corporations and corporate information.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Corporations and corporate information. 227.6 Section 227... § 227.6 Corporations and corporate information. (a) If the applicant for a lease is a corporation, it... the lands are located, evidence showing compliance with the corporation laws thereof. Statements...

  15. 25 CFR 213.14 - Corporations and corporate information.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Corporations and corporate information. 213.14 Section... Corporations and corporate information. If the applicant for a lease is a corporation, it shall file evidence..., evidence showing compliance with the corporation laws thereof. Statements of changes in officers...

  16. Corporate communications impact on corporate image and corporate competitiveness

    OpenAIRE

    Valentina Pirić

    2008-01-01

    The subject of this paper is an analysis of the impact of corporate communications and of the intensity of their application on a company’s image management, and an emphasis of the role that a company’s image plays as one of the fundamental sources of its competitiveness in contemporary market conditions. Through review and analysis of theoretical contributions, the paper shows how corporate communications integrate management, organization and the marketing communication dimension at the lev...

  17. BRAF V600E mutation in prognostication of papillary thyroid cancer (PTC) recurrence.

    Science.gov (United States)

    Czarniecka, Agnieszka; Oczko-Wojciechowska, Małgorzata; Barczyński, Marcin

    2016-10-01

    Papillary thyroid cancer (PTC) offers excellent prognosis, however relapse risk or persistent disease is related to ~30%. Currently, attention is paid to the possibility of patient group selection of different risk of unfavorable outcome to match a particular therapeutic approach. Therefore, interest in new prognostic and predictive markers known preoperatively is observed. BRAF V600E mutation is such a marker. Many studies analyzing the prevalence of the mutation and its relationship with other clinico-pathological risk factors were reported but with controversial conclusions. The prognostic significance of BRAF mutation was confirmed by some single centre studies, a few meta-analyses and a large multicenter retrospective international study. They confirmed a correlation between the mutation and the risk of recurrence. The strongest argument against using BRAF mutation as an independent prognostic and predictive factor in PTC is its high prevalence (30-80%). At present it seems that BRAF mutation is one of the factors influencing the prognosis and it should be analyzed in correlation with other prognostic factors. The most recent ATA recommendations do not indicate a routine application of BRAF status for initial risk stratification in differentiated thyroid cancer due to a lack of evident confirmation of a direct influence of mutation on the increase in relapse risk. However, ATA demonstrates the continuous risk scale for the relapse risk assessment, considering BRAF and/or TERT status. At present, researchers are working on determining the role of BRAF mutation in patients from a low-risk group and its correlations with others molecular events. Currently, BRAF mutation cannot be used as a single, independent predictive factor. However, its usefulness in the context of other molecular and clinico-pathological risk factors cannot be excluded. They may be used to make modern prognostic scales of relapse risk and be applied to individualized diagnostic and

  18. Evolution of Corporate Essence

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2016-01-01

    , it offers a legal framework where public benefit is more important than profits. As a corporate entity, Public Benefit Corporation already exists in numerous jurisdictions and those jurisdictions that do not yet facilitate creation of this corporate form should most definitely consider it....

  19. Reinventing Corporate Communications.

    Science.gov (United States)

    Toth, Elizabeth L.; Trujillo, Nick

    1987-01-01

    Urges a "re-inventing" of corporate communications in today's organizations, and provides information about how corporations can change in new and positive ways during the current "information age." Discusses specific public relations and organizational communication concepts essential for a comprehensive understanding of corporate communications…

  20. A COMPETITIVE MODEL BASED IN FREE SOFTWARE TOOLS FOR THE TECHNOLOGICAL MANAGEMENT OF ORGANIZATIONS - THE PROMOTION OF THE CORPORATIVE KNOWLEDGE AND THE TECHNOLOGICAL INNOVATION IN A TECHNOLOGICAL UNDERGRADUATE COURSE

    OpenAIRE

    Rubens Araújo de Oliveira; Mário Lucio Roloff

    2007-01-01

    This article presents the thematic of the technological management, where the research is focused on the choice of the best technological free software tools for the promotion of the knowledge management. This article evidences the hypothesis that it is possible to adopt the knowledge management with the union and customization of the free software tools. In such a way, any organization can act in the technological management and apply the politics of knowledge management, either to a micro-c...

  1. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC.

    Science.gov (United States)

    Occhi, Gianluca; Barollo, Susi; Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco; Scaroni, Carla; Mian, Caterina

    2015-10-13

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAFV600E may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice.

  2. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

    Science.gov (United States)

    Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco; Scaroni, Carla; Mian, Caterina

    2015-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAFV600E may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice. PMID:26392334

  3. DNA sequence analysis of the composite plasmid pTC conferring virulence and antimicrobial resistance for porcine enterotoxigenic Escherichia coli.

    Science.gov (United States)

    Fekete, Péter Z; Brzuszkiewicz, Elzbieta; Blum-Oehler, Gabriele; Olasz, Ferenc; Szabó, Mónika; Gottschalk, Gerhard; Hacker, Jörg; Nagy, Béla

    2012-01-01

    In this study the plasmid pTC, a 90 kb self-conjugative virulence plasmid of the porcine enterotoxigenic Escherichia coli (ETEC) strain EC2173 encoding the STa and STb heat-stable enterotoxins and tetracycline resistance, has been sequenced in two steps. As a result we identified five main distinct regions of pTC: (i) the maintenance region responsible for the extreme stability of the plasmid, (ii) the TSL (toxin-specific locus comprising the estA and estB genes) which is unique and characteristic for pTC, (iii) a Tn10 transposon, encoding tetracycline resistance, (iv) the tra (plasmid transfer) region, and (v) the colE1-like origin of replication. It is concluded that pTC is a self-transmissible composite plasmid harbouring antibiotic resistance and virulence genes. pTC belongs to a group of large conjugative E. coli plasmids represented by NR1 with a widespread tra backbone which might have evolved from a common ancestor. This is the first report of a completely sequenced animal ETEC virulence plasmid containing an antimicrobial resistance locus, thereby representing a selection advantage for spread of pathogenicity in the presence of antimicrobials leading to increased disease potential. Copyright © 2011. Published by Elsevier GmbH.

  4. Top Executive Succession in Chinese Corporations

    Institute of Scientific and Technical Information of China (English)

    FENG Tian-li; JING Run-tian; WANG Guo-feng

    2006-01-01

    Top executive succession is one of the most crucial events in the life of any firm.Based on the database of Chinese Entrepreneur Survey System, this research firstly reports new factors that influence the likelihood of succession in Chinese corporations, which may not exist in western companies, then tests previous western research result in Chinese information technology(IT) industry and traditional industry. The results are hopefully to enlighten the reform of corporations during the period of China transitional economy.

  5. Methanol electro-oxidation on Pt/C modified by polyaniline nanofibers for DMFC applications

    Energy Technology Data Exchange (ETDEWEB)

    Zhiani, Mohammad; Rezaei, Behzad; Jalili, Jalal [Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111 (Iran)

    2010-09-15

    In the present study, in order to achieve an inexpensive tolerable anode catalyst for direct methanol fuel cell applications, a composite of polyaniline nanofibers and Pt/C nano-particles, identified by PANI/Pt/C, was prepared by in-situ electropolymerization of aniline and trifluoromethane sulfonic acid on glassy carbon. The effect of synthesized PANI nanofibers in methanol electrooxidation reaction was compared by bare Pt/C by different electrochemical methods such as; cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Scanning electron microscopy (SEM) was also employed to morphological study of the modified catalyst layer. The test results reveal that introduction of PANI nanofibers within catalyst layer improves the catalyst activity in methanol oxidation, hinders and prevents catalyst from more poisoning by intermediate products of methanol oxidation and improves the mechanical properties of the catalyst layer. SEM images also indicate that PANI nanofibers placed between platinum particles and anchor platinum particles and alleviate the Pt migration during methanol electrooxidation. (author)

  6. Increase of a group of PTC(+) transcripts by curcumin through inhibition of the NMD pathway.

    Science.gov (United States)

    Feng, Dairong; Su, Ruey-Chyi; Zou, Liping; Triggs-Raine, Barbara; Huang, Shangzhi; Xie, Jiuyong

    2015-08-01

    Nonsense-mediated mRNA decay (NMD), an mRNA surveillance mechanism, eliminates premature termination codon-containing (PTC⁺) transcripts. For instance, it maintains the homeostasis of splicing factors and degrades aberrant transcripts of human genetic disease genes. Here we examine the inhibitory effect on the NMD pathway and consequent increase of PTC+ transcripts by the dietary compound curcumin. We have found that several PTC⁺ transcripts including that of serine/arginine-rich splicing factor 1 (SRSF1) were specifically increased in cells by curcumin. We also observed a similar curcumin effect on the PTC⁺ mutant transcript from a Tay-Sachs-causing HEXA allele or from a beta-globin reporter gene. The curcumin effect was accompanied by significantly reduced expression of the NMD factors UPF1, 2, 3A and 3B. Consistently, in chromatin immunoprecipitation assays, curcumin specifically reduced the occupancy of acetyl-histone H3 and RNA polymerase II at the promoter region (-376 to -247nt) of human UPF1, in a time- and dosage-dependent way. Importantly, knocking down UPF1 abolished or substantially reduced the difference of PTC(+) transcript levels between control and curcumin-treated cells. The disrupted curcumin effect was efficiently rescued by expression of exogenous Myc-UPF1 in the knockdown cells. Together, our data demonstrate that a group of PTC⁺ transcripts are stabilized by a dietary compound curcumin through the inhibition of UPF factor expression and the NMD pathway.

  7. Taste Quality Confusions: Influences of Age, Smoking, PTC Taster Status, and other Subject Characteristics.

    Science.gov (United States)

    Doty, Richard L; Chen, Jonathan H; Overend, Jane

    2017-01-01

    Many persons misidentify the quality of taste stimuli, a phenomenon termed "taste confusion." In this study of 1000 persons, we examined the influences of age, sex, causes of chemosensory disturbances, and genetically determined phenylthiocarbamide (PTC) taster status on taste quality confusions for four tastants (sucrose, citric acid, sodium chloride, caffeine). Overall, sour-bitter confusions were most common (19.3%), followed by bitter-sour (11.4%), salty-bitter (7.3%), salty-sour (7.0%), bitter-salty (3.5%), bitter-sweet (3.4), and sour-salty (2.4%) confusions. Confusions for sweet were PTC tasters had fewer confusions than non-tasters except for salty-bitter confusions. Confusions typically increased monotonically with age. Current smokers exhibited more sour-bitter confusions than never smokers (48.9% vs. 32.2%), whereas past smokers had more bitter-sour confusions than never smokers (23.8% vs. 14.2%). Previous head trauma was associated with higher bitter-salty and salty-bitter confusions relative to those of some other etiologies. This study demonstrates, for the first time, that multiple subject factors influence taste confusions and, along with literature accounts, supports the view that there are both biological and psychological determinants of taste quality confusions.

  8. Effects of corporate governance on corporate reputation

    OpenAIRE

    López González, Eva

    2015-01-01

    One of the most critical strategic and enduring assets that a corporation may possess is good reputation. The positive impact of corporate reputation on firm performance has been analyzed and documented for ages. Intangible assets like reputation are increasing their importance in companies as sources of sustainable advantages. Organizations used to look for tangible assets as the drivers of these advantages, but nowadays intangible ones are getting much more weight in this sense. This is wh...

  9. CORPORATE GOVERNANCE RELATION WITH CORPORATE SUSTAINABILITY

    OpenAIRE

    ISSAM MF SALTAJI

    2013-01-01

    Sustainability is targeted in this article to be integrated with corporate governance presenting its importance in business world not as obligation, but as a tool be adopted. Economic challenges push companies to think twice before making decisions. Corporate governance is a success key for companies through improving performance and gain mistrust of investors serving business sustainability. Objectives direction has been changed from concentrating on shareholders’ benefits to maintain sustai...

  10. CORPORATE GOVERNANCE RELATION WITH CORPORATE SUSTAINABILITY

    OpenAIRE

    ISSAM MF SALTAJI

    2013-01-01

    Sustainability is targeted in this article to be integrated with corporate governance presenting its importance in business world not as obligation, but as a tool be adopted. Economic challenges push companies to think twice before making decisions. Corporate governance is a success key for companies through improving performance and gain mistrust of investors serving business sustainability. Objectives direction has been changed from concentrating on shareholders’ benefits to maintain sustai...

  11. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.

    Science.gov (United States)

    Mao, Feifei; Yang, Xiaofeng; Fu, Lin; Lv, Xiangdong; Zhang, Zhao; Wu, Wenqing; Yang, Siqi; Zhou, Zhaocai; Zhang, Lei; Zhao, Yun

    2014-08-08

    The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments that derive from adjacent cell populations. The anterior/posterior (A/P) boundaries, which are critical to maintaining the position of organizers, are established by a complex mechanism involving Hh signaling. Here, we uncover the regulation of ptc in the Hh signaling pathway by two subunits of mediator complex, Kto and Skd, which can also regulate boundary location. Collectively, we provide further evidence that Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Inflammatory mediators, tumor necrosis factor-α and interferon-γ, induce EMT in human PTC cell lines.

    Science.gov (United States)

    Lv, Nannan; Gao, Yun; Guan, Haixia; Wu, Dan; Ding, Shuangning; Teng, Weiping; Shan, Zhongyan

    2015-10-01

    Inflammatory mediators, tumor necrosis factor (TNF)-α and interferon (IFN)-γ, promote adverse outcomes in numerous types of cancer; however, their role in papillary thyroid cancer (PTC) remains unclear. The aim of the present study was to investigate the influence of TNF-α and IFN-γ on the migration, invasion and epithelial-mesenchymal transition (EMT) of the three PTC cell lines, TPC-1, BCPAP and K1. The effect of TNF-α and IFN-γ on cell migration and invasion was assessed by wound-healing and Transwell assays. In addition, the mRNA and protein expression levels of the EMT makers, E-cadherin, N-cadherin and vimentin, were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunoblot analysis. The wound-healing and Transwell experiments revealed that TNF-α and IFN-γ increased the migratory and invasive behavior of PTC cells (PPTC cells.

  13. Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment.

    Science.gov (United States)

    Bolomsky, Arnold; Schlangen, Karin; Schreiner, Wolfgang; Zojer, Niklas; Ludwig, Heinz

    2016-03-02

    The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, we investigated PTC-209, a novel small molecule inhibitor of BMI-1, for its activity in MM. BMI-1 expression was analysed in human MM cell lines and primary MM cells by using publically available gene expression profiling (GEP) data. The anti-MM activity of PTC-209 was investigated by viability testing, cell cycle analysis, annexin V and 7-AAD staining, quantification of cleaved poly(ADP-ribose) polymerase (PARP), JC-1 as well as colony formation assays. Deregulation of central myeloma growth and survival genes was studied by quantitative PCR and flow cytometry, respectively. In addition, the impact of PTC-209 on in vitro osteoclast, osteoblast and tube formation was analysed. We confirmed overexpression of BMI-1 in MM patients by using publically available GEP datasets. Of note, BMI-1 expression was further increased at relapse which translated into significantly shorter overall survival in relapsed/refractory patients treated with bortezomib or dexamethasone. Treatment with PTC-209 significantly decreased viable cell numbers in human MM cell lines, induced a G1 cell cycle arrest, promoted apoptosis and demonstrated synergistic activity with pomalidomide and carfilzomib. The anti-MM activity of PTC-209 was accompanied by a significant decrease of cyclin D1 (CCND1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC) expression as well as upregulation of cyclin-dependent kinase inhibitor 1A (CDKN1A) and cyclin-dependent kinase inhibitor 1B (CDKN1B). We also observed upregulation of NOXA (up to 3.6 ± 1.2-fold induction, P = 0.009) and subsequent downregulation of myeloid cell leukemia 1 (MCL-1) protein levels, which likely mediates the apoptotic effects of PTC-209

  14. Corporate environmentalism and environmental innovation.

    Science.gov (United States)

    Chang, Ching-Hsing; Sam, Abdoul G

    2015-04-15

    Several papers have explored the effect of tighter environmental standards on environmental innovation. While mandatory regulation remains the central tenet of US environmental policy, the regulatory landscape has changed since the early 1990s with the increased recourse by federal and state agencies to corporate environmentalism--voluntary pollution prevention (P2) by firms--to achieve environmental improvements. We therefore estimate the effects of voluntary P2 activities on the patenting of environmental technologies by a sample of manufacturing firms. With our panel data of 352 firms over the 1991-2000 period, we adopt an instrumental variable Poisson framework to account for the count nature of patents and the endogeneity of the P2 adoption decision. Our results indicate that the adoption of voluntary P2 activities in the manufacturing sector has led to a statistically and economically significant increase in the number of environmental patents, suggesting that corporate environmentalism can act as a catalyst for investments in cleaner technologies. Our findings are internationally relevant given the increasing ubiquity of corporate environmentalism in both developed and developing economies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. CORPORATE GOVERNANCE IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Ciprian Apostol

    2015-09-01

    Full Text Available The objective of the research was focused on measuring the performance level of corporate governance in Romania. This is carried out by evaluating the importance level given to the principles of corporate governance in the Romanian economy, while the practices of transparency and dissemination of companies’ information in the selected sample were monitored. To achieve the objectives of the study, we need to examine the Corporate Governance Code of the Bucharest Stock Exchange. Sample companies were selected and their information from the “Comply or Explain” Statements was analyzed.The research method is a non-participating observation—based on the information from the “Comply or Explain” Statement to determine whether companies are applying corporate governance and transparency elements. The research results highlight the progress of Romanian companies in the process of exercising to the principles of corporate governance, becoming internationally recognized, and integrating into the Corporate Governance Code of the Bucharest Stock Exchange.

  16. The Corporate Marketing Department

    DEFF Research Database (Denmark)

    Ritter, Thomas; Eggert, Andreas; Münkhoff, Eva

    it can best add value to the firm. Based on a qualitative study among B2B companies, we develop a conceptual framework highlighting the various parental roles through which corporate marketing can contribute to overall firm and business unit performance. In addition, we identify five gaps that restrain......Corporate marketing has been downsized or eliminated in many firms. At the same time, firms that still own a corporate marketing department struggle with organizing and positioning their commercial front‐end. The question arises whether firms need a corporate marketing department, and if so, how...... successful outcomes of corporate marketing activities. In sum, our framework provides important insights on how to successfully organize corporate marketing activities....

  17. 25 CFR 226.8 - Corporation and corporate information.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Corporation and corporate information. 226.8 Section 226... RESERVATION LANDS FOR OIL AND GAS MINING Leasing Procedure, Rental and Royalty § 226.8 Corporation and corporate information. (a) If the applicant for a lease is a corporation, it shall file evidence...

  18. 76 FR 59170 - Hartford Financial Services, Inc., Corporate/EIT/CTO Database Management Division, Hartford, CT...

    Science.gov (United States)

    2011-09-23

    ... Employment and Training Administration Hartford Financial Services, Inc., Corporate/EIT/CTO Database...) applicable to workers and former workers Hartford Financial Services, Inc., Corporate/EIT/CTO Database... services. Specifically, the workers provide information technology support for the firm's...

  19. Corporate governance in Malaysia

    National Research Council Canada - National Science Library

    SINGAM, Kamini

    2003-01-01

    ... governance in Malaysia - the ownership structure, composition and operation of Malaysian companies in Malaysia - the nature of shareholder control and protection made available in the Malaysian corporate...

  20. Genetic characterization of the CcpA-dependent, cellobiose-specific PTS system comprising CelB, PtcB and PtcA that transports lactose in Lactococcus lactis IL1403.

    Science.gov (United States)

    Aleksandrzak-Piekarczyk, Tamara; Polak, Jolanta; Jezierska, Beata; Renault, Pierre; Bardowski, Jacek

    2011-01-31

    Lactose metabolism is one of the most important areas of research on Lactic Acid Bacteria (LAB). In rapidly acidifying industrial Lactococcus lactis strains, lactose is transported by a lactose-specific phosphotransferase system (PTS) encoded by a plasmid. However, an alternative lactose catabolic pathway was evidenced in the plasmid-cured, and thus initially lactose-negative L. lactis IL1403. We showed that in this strain the chromosomally-encoded cellobiose-specific PTS system comprising the celB, ptcB and ptcA genes is also able to transport lactose. By expression studies in the wild type IL1403 strain and IBB550, its ccpA-deficient derivative, we demonstrated that celB, ptcB and ptcA are tightly regulated by the general catabolite repression system, whereas celB additionally requires the presence of cellobiose to be fully induced. The comparison of expression levels of sugar catabolic genes indicated that the efficiency of CcpA-mediated catabolic repression depends on conservation of the cre sequence, and that in the case of perfect matching with the cre consensus, CcpA still drives a strong repression even under non-repressing conditions.

  1. Corporate Social Responsibility, Reputation, and Moral Communication

    DEFF Research Database (Denmark)

    Schultz, Friederike

    2013-01-01

    Conditions and notions of corporate reputation underwent in the last years a fundamental change. Economic and technological processes of globalization, modernization, and rationalization enforced the institutionalization of corporate social responsibility (CSR) in the corporate world. It is often...... assumed, that CSR positively affects corporate reputation and leads to financial benefits, although empirical evidence and an appropriate conceptualization of reputation are often missing. This chapter discusses the relation between CSR and reputation by taking a meta-perspective: it presents...... and critically discusses insights from instrumental perspectives and from political-normative perspectives (legitimacy, business ethics). It alternatively develops a constructivist communication view on CSR, building on the “communication constitutes organizations” perspective and a non-dualist turn. It argues...

  2. Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: testing the evidence for an endophenotypic marker.

    Science.gov (United States)

    Brewer, Warrick J; Lin, Ashleigh; Moberg, Paul J; Smutzer, Gregory; Nelson, Barnaby; Yung, Alison R; Pantelis, Christos; McGorry, Patrick D; Turetsky, Bruce I; Wood, Stephen J

    2012-08-30

    Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Corporate Governance Country Assessment : Malaysia

    OpenAIRE

    World Bank

    2012-01-01

    This report assesses Ghana s corporate governance policy framework. It highlights recent improvements in corporate governance regulation, makes policy recommendations, and provides investors with a benchmark against which to measure corporate governance in Ghana. It is an update of the 2005 Corporate Governance ROSC. Good corporate governance enhances investor trust, helps to protects mino...

  4. Modifications and Modeling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. Data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  5. Recent Updates to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIP, provided by Idaho National Laboratory (1NL), is the subject of the first round of experimentation. This presentation details the physical changes made to the FSP-PTC and the current test program.

  6. PTC/NTC Behavior of PVDF Composites Filled with GF and CF

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-lei; ZHANG Guo; LI Ji-xin; LI Zhuo-shi; LIU Zhan-fang; LIU Xiu-qi

    2008-01-01

    Conductive polyvinylidene fluoride(PVDF) matrix composites filled with graphited fiber(GF) or carbon fiber(CF) were prepared by the melt-mixing method.The breakage and length distribution of the fibers in the polymer matrix were studied by scanning electron microscope(SEM) and optical microscope(OM) observations,respectively.The differences in the positive temperature coefficient(PTC) effects of the composites were mainly attributed to inter-fiber contact ability.The elimination of the negative temperature coefficient(NTC) effect for CF/PVDF composite was because of an increase in the viscosity of the polymer matrix.With the same filler content,CF could be more effective,to eliminate the NTC effect when compared with GF.Addition of 2% CF(mass fraction) in the PVDF composite with 7% GF(mass fraction) could effectively eliminate the NTC phenomenon of the composite.

  7. Nickel-doped ceria nanoparticles for promoting catalytic activity of Pt/C for ethanol electrooxidation

    Science.gov (United States)

    Tan, Qiang; Du, Chunyu; Sun, Yongrong; Du, Lei; Yin, Geping; Gao, Yunzhi

    2014-10-01

    This paper reports the facile synthesis of monodispersed nickel-doped ceria nanoparticles by a thermal decomposition method, which is used to promote catalytic properties of Pt/C. The Pt/Ni-doped CeO2/C catalyst obtained exhibits remarkably high activity and stability towards the ethanol electrooxidation in acidic media. This is attributed to higher oxygen releasing capacity and stronger interaction of Ni-doped CeO2 with Pt than pure CeO2 nanoparticles that contribute positively to the removal of poisoning intermediates. We believe that the design concept and synthetic strategy of metal doped oxides used for fuel cell catalysts can be potentially extended to other catalytic fields.

  8. Modifications and Modeling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. Data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  9. PTC simulations, stochastic optimization and safety strategies for groundwater pumping management: case study of the Hersonissos Coastal Aquifer in Crete

    Science.gov (United States)

    Stratis, P. N.; Dokou, Z. A.; Karatzas, G. P.; Papadopoulou, E. P.; Saridakis, Y. G.

    2016-06-01

    Recently, the well-known Princeton Transport Code (PTC), a groundwater flow and contaminant transport simulator, has been coupled with the ALgorithm of Pattern EXtraction (ALOPEX), a real-time stochastic optimization method, to provide a freshwater pumping management tool for coastal aquifers, aiming in preventing saltwater intrusion. In our previous work (Proceedings of INASE/CSCC-WHH 2015, Recent Advances in Environmental and Earth Sciences and Economics, pp 329-334, 2015), the PTC-ALOPEX approach was used in studying the saltwater contamination problem for the coastal aquifer at Hersonissos, Crete. Extending these results, in the present study the PTC-ALOPEX approach is equipped with a nodal safety strategy that effectively controls saltwater front's advancement inside the aquifer. In cooperation with an appropriate penalty system, the performance of PTC-ALOPEX algorithm is studied considering several pumping and weather condition scenarios. This study also establishes pumping/well scenarios that ensure the needed volume of fresh water to the local community without risking saltwater contamination.

  10. Successful Strategies for Rapidly Upgrading PTC Windchill 9.1 to Windchill 10.1 on a Light Budget

    Science.gov (United States)

    Shearrow, Charles A.

    2013-01-01

    Topics covered include: The Frugal Times Historical Upgrade Process; Planning for Possible Constraints; PTC Compatibility Matrix; In-Place Upgrade Process; Pre-Upgrade Activities; Upgrade Activities; Post Upgrade Activities; Results of the Upgrade; Tips for an Upgrade On a Shoestring Budget.

  11. Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India.

    Science.gov (United States)

    Hussain, Ruqaiya; Shah, Ahsana; Afzal, Mohammad

    2014-04-01

    The ability to taste Phenylthiocarbamide (PTC), a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place. Unrelated, healthy individuals of both sexes (Male-403, Female-418) belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus. The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2)= 11.92, df = 5, P = 0.036). There were more females among tasters (67.94%) than males (64.76%). This observation was statistically significant (χ(2) = 14.79, df = 5, P = 0.011). The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.

  12. Development of latent fingermarks on surfaces submerged in water: Optimization studies for phase transfer catalyst (PTC) based reagents.

    Science.gov (United States)

    Jasuja, O P; Kumar, Parveen; Singh, Gagandeep

    2015-09-01

    The use of a phase transfer catalyst (PTC) based reagent for the development of latent fingermarks is relatively a recent one and therefore a thorough evaluation is required before making any suggestion for its use in the routine fingermark development protocol. In the present study, non-porous surfaces including the sticky side of adhesive tapes loaded with latent fingermarks (eccrine, groomed and natural fingermarks) were submerged in water for different times and were treated with a PTC based reagent to develop fingermarks. The PTC based reagent was able to develop latent fingermarks on various surfaces submerged in water for different time intervals. The proposed method has been compared with standard methods like superglue fuming, small particle reagent and gentian violet (for adhesive tapes). The results have shown that the duration of submersion and the method selected for visualization have influences on the quality of developed fingermarks. The performance of the PTC technique against conventional methods was evaluated and compared thoroughly as a part of the optimization studies for the reagent. Copyright © 2015 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

  13. The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas.

    Science.gov (United States)

    Cetta, F; Chiappetta, G; Melillo, R M; Petracci, M; Montalto, G; Santoro, M; Fusco, A

    1998-03-01

    Familial adenomatous polyposis (FAP) is caused by germ-line mutations of the apc gene, and it is associated with an increased risk of developing papillary thyroid carcinomas. We have previously reported that a significant fraction of sporadic human papillary thyroid carcinomas is characterized by gene rearrangements affecting the ret protooncogene. These rearrangements generate chimeric transforming oncogenes designated ret/ptc. By a combined immunohistochemical and RT-PCR approach, we analyzed, for ret/ptc oncogene activation, papillary thyroid carcinomas occurred in two FAP kindreds, both showing typical apc gene mutations. Kindred 1 had seven members affected by FAP, and among these, three patients showed papillary thyroid carcinomas. Kindred 2 had two patients, mother and daughter, affected by colonic polyposis; the 20-yr-old daughter showed also a papillary carcinoma. Here we report that ret/ptc1 oncogene was activated in two of the three papillary carcinomas of FAP kindred 1 and in the papillary carcinoma of FAP kindred 2. These findings document that loss of function of apc coexists with gain of function of ret in some papillary thyroid carcinomas, suggesting that ret/ptc1 oncogene activation could be a progression step in the development of FAP-associated thyroid tumors.

  14. PTC simulations, stochastic optimization and safety strategies for groundwater pumping management: case study of the Hersonissos Coastal Aquifer in Crete

    Science.gov (United States)

    Stratis, P. N.; Dokou, Z. A.; Karatzas, G. P.; Papadopoulou, E. P.; Saridakis, Y. G.

    2017-09-01

    Recently, the well-known Princeton Transport Code (PTC), a groundwater flow and contaminant transport simulator, has been coupled with the ALgorithm of Pattern EXtraction (ALOPEX), a real-time stochastic optimization method, to provide a freshwater pumping management tool for coastal aquifers, aiming in preventing saltwater intrusion. In our previous work (Proceedings of INASE/CSCC-WHH 2015, Recent Advances in Environmental and Earth Sciences and Economics, pp 329-334, 2015), the PTC-ALOPEX approach was used in studying the saltwater contamination problem for the coastal aquifer at Hersonissos, Crete. Extending these results, in the present study the PTC-ALOPEX approach is equipped with a nodal safety strategy that effectively controls saltwater front's advancement inside the aquifer. In cooperation with an appropriate penalty system, the performance of PTC-ALOPEX algorithm is studied considering several pumping and weather condition scenarios. This study also establishes pumping/well scenarios that ensure the needed volume of fresh water to the local community without risking saltwater contamination.

  15. Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC Among Some Muslim Populations of Uttar Pradesh, India.

    Directory of Open Access Journals (Sweden)

    Ruqaiya Hussain

    2015-04-01

    Full Text Available The ability to taste Phenylthiocarbamide (PTC, a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place.Unrelated, healthy individuals of both sexes (Male-403, Female-418 belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus.The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2= 11.92, df = 5, P = 0.036. There were more females among tasters (67.94% than males (64.76%. This observation was statistically significant (χ(2 = 14.79, df = 5, P = 0.011.The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.

  16. Expanding educational access and opportunities: The globalization and foreign direct investment of multinational corporations and their influence on STEM, project-based learning and the national science and technology fair in schools in Costa Rica

    Science.gov (United States)

    Valdez, Joaquin G.

    The purpose of this qualitative study was to examine the influence of globalization and the foreign direct investment (FDI) of multinational corporations (MNCs) on the curriculum in schools in Costa Rica. The study focused primarily on Science, Technology, Engineering and Mathematics (STEM), Project-Based Learning (PBL), 21st century skills, and the national science and technology fair. The high influx of MNCs such as Intel has changed the global and educational culture of the country increasing the number of knowledge-based workers in Costa Rica. As a result, policy changes have been instituted in education to mirror the demands of sustaining the country's global economy. This study was supported by the creation of three research questions that would attempt to answer 1) the extent that teachers implementing STEM curriculum trace their practices back to policy, globalization, and multinational corporations as well as the extent to which the economic growth of Costa Rica and STEM education are related, 2) how mandating the national science and technology fair has influenced 21st century skills through project-based learning and the use of technology by teachers and its impact on curriculum and instruction, and 3) how has the national science and technology fair policy changed the value of STEM education for students, teachers, and educational leaders. To further understand the outcome of this study, four theoretical frameworks were applied that included, Spring's theory of world educational culture, Friedman's world flatteners, Wagner's 21st century skills and partnerships for 21st century skills, and Slough and Milam's STEM project-based learning theoretical framework. Each framework was applied to support the changes to the educational system; survival skills necessary to compete in the global job market; application of 21st century skills in the classroom and in the science projects students created. A research team comprised of 14 doctoral students, led by Dr

  17. Understanding Corporate Culture.

    Science.gov (United States)

    Cluff, Gary A.

    1988-01-01

    Considers concept of corporate culture and discusses several values which can be considered when assessing corporate culture, and the "compatibility scales" used to measure them. Included are discussions of employee attitudes, work atmosphere, internal communications, management style, employment opportunity, stability, business ethics, corporate…

  18. Corporate Bankruptcy Tourists

    NARCIS (Netherlands)

    Couwenberg, Oscar; Lubben, Stephen J.

    2015-01-01

    Foreign corporations facing financial distress have a choice: resructure in their home jurisdiction or file for bankruptcy in the United States. And some number of foreign corporations do file bankruptcy petitions in the United States. But besides the occasional anecdotal account, how frequently thi

  19. Efficiency in Corporate Takeovers

    NARCIS (Netherlands)

    Y. Dai (Yun)

    2014-01-01

    markdownabstractCorporate takeover is a very important economic activity that generates profound consequences on many classes of market participants. The great financing needs and transaction costs directly change the wealth of both shareholders and creditors. The corporate restructuring induced by

  20. Corporate Media Governance

    NARCIS (Netherlands)

    Kempen, Petrus Cornelis

    2011-01-01

    The media can make or break a reputation. This being said, it seems to be essential for companies, governments and institutions to pay specific attention to corporate media management in their daily operations. However, this thesis shows that they often neglect to pay adequate attention to corporate

  1. Corporate Bankruptcy Tourists

    NARCIS (Netherlands)

    Couwenberg, Oscar; Lubben, Stephen J.

    2015-01-01

    Foreign corporations facing financial distress have a choice: resructure in their home jurisdiction or file for bankruptcy in the United States. And some number of foreign corporations do file bankruptcy petitions in the United States. But besides the occasional anecdotal account, how frequently

  2. Corporate Media Governance

    NARCIS (Netherlands)

    Kempen, Petrus Cornelis

    2011-01-01

    The media can make or break a reputation. This being said, it seems to be essential for companies, governments and institutions to pay specific attention to corporate media management in their daily operations. However, this thesis shows that they often neglect to pay adequate attention to corporate

  3. Corporate Crime and Restitution.

    Science.gov (United States)

    Abel, Charles F.

    1985-01-01

    Articulates need, nature, and form of a restitutionary approach to corporate crime. Considers small, in-prison production-oriented programs; residential in-community programs, and nonresidential in-community programs for individual offenders; also considers lump sum and continuous payments for corporations to make restitution. (NRB)

  4. Reinventing Corporate Communications.

    Science.gov (United States)

    Toth, Elizabeth L.; Trujillo, Nick

    1987-01-01

    Urges a "re-inventing" of corporate communications in today's organizations, and provides information about how corporations can change in new and positive ways during the current "information age." Discusses specific public relations and organizational communication concepts essential for a comprehensive understanding of…

  5. Corporation as climate ambassador

    DEFF Research Database (Denmark)

    Trapp, Leila

    2012-01-01

    At a time when corporations are addressing increasingly complex, global corporate social responsibility (CSR) issues, this study examines and evaluates the strategies used in Vattenfall’s challenging and innovative CSR campaign which aimed at establishing the energy company as a credible climate...

  6. Institutional conditions of corporate citizenship

    NARCIS (Netherlands)

    Jeurissen, R.J.M.

    2004-01-01

    Exploring the concept of citizenship from the history of political philosophy provides suggestions about what corporate citizenship could mean. The metaphor of corporate citizenship suggests an institutional approach to corporate social responsibility. Citizenship is a social role, characterized by

  7. Institutional conditions of corporate citizenship

    NARCIS (Netherlands)

    Jeurissen, R.J.M.

    2004-01-01

    Exploring the concept of citizenship from the history of political philosophy provides suggestions about what corporate citizenship could mean. The metaphor of corporate citizenship suggests an institutional approach to corporate social responsibility. Citizenship is a social role, characterized by

  8. CORPORATE GOVERNANCE TERHADAP KINERJA PERUSAHAAN

    Directory of Open Access Journals (Sweden)

    Herman Darwis

    2017-03-01

    Full Text Available The research aimed to provide empirical evidence that corporate governance implementation,managerial ownership, institutional ownership, board of executive, and independent executiveaffected corporate performance. Population of the research was companies listed at IndonesianStock Exchange (ISX between 2006 – 2008; sampling method used was purposive sampling as well asmultiple regression analysis. The result showed the implementation of GCG affected corporate performance.This meant that if the listed companies at BEI and have been surveyed by IICG implement agood corporate governance, the performance would increase. The higher corporate governance wasmeasured by corporate governance index perception, the higher corporate obedience and result ina good corporate performance. Institutional ownership affected corporate performance. The greaterinstitutional share ownership, the better corporate performance. The result showed that controlfunction from the ownership did determine improving corporate performance. Managerial ownership,board of commissioner, and commissioner independent did not affect corporate.

  9. Corporate Language Policies

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    This paper offers a review of literature dealing with language policies in general and corporate language policies in particular. Based on a discussion of various definitions of these concepts within two research traditions, i.e. sociolinguistics and international management, a three......-level definition of corporate language policies is presented, emphasising that a corporate language policy is a context-specific policy about language use. The three-level definition is based on the argument that in order to acquire a complete understanding of what corporate language policies involve, one needs...... to consider three progressive questions; 1) what is a policy? 2) what is a language policy?, and ultimately, 3) what is a corporate language policy?...

  10. Corporate Language Policies

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    2015-01-01

    This paper offers a review of literature dealing with language policies in general and corporate language policies in particular. Based on a discussion of various definitions of these concepts within two research traditions, i.e. sociolinguistics and international management, a three......-level definition of corporate language policies is presented, emphasising that a corporate language policy is a context-specific policy about language use. The three-level definition is based on the argument that in order to acquire a complete understanding of what corporate language policies involve, one needs...... to consider three progressive questions; 1) what is a policy? 2) what is a language policy?, and ultimately, 3) what is a corporate language policy?...

  11. THEORIES OF CORPORATE GOVERNANCE

    Directory of Open Access Journals (Sweden)

    Sorin Nicolae BORLEA

    2013-03-01

    Full Text Available This study attempts to provide a theoretical framework for the corporate governance debate. The review of various corporate governance theories enhances the major objective of corporate governance which is maximizing the value for shareholders by ensuring good social and environment performances. The theories of corporate governance are rooted in agency theory with the theory of moral hazard’s implications, further developing within stewardship theory and stakeholder theory and evolving at resource dependence theory, transaction cost theory and political theory. Later, to these theories was added ethics theory, information asymmetry theory or the theory of efficient markets. These theories are defined based on the causes and effects of variables such as: the configuration of the board of directors, audit committee, independence of managers, the role of top management and their social relations beyond the legal regulatory framework. Effective corporate governance requires applying a combination

  12. Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells

    Energy Technology Data Exchange (ETDEWEB)

    Abou-El-Ardat, Khalil, E-mail: kabouela@sckcen.be [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Monsieurs, Pieter [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); Anastasov, Natasa; Atkinson, Mike [Department of Radiation Sciences, Helmholtz Zentrum Muenchen, Munich (Germany); Derradji, Hanane [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); De Meyer, Tim [Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Department of Applied Mathematics, Biometrics and Process Control, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Bekaert, Sofie [Clinical Research Center, Faculty for Medicine and Health Sciences, Universiteit Gent, 185 De Pintelaan, 9000 Ghent (Belgium); Van Criekinge, Wim [Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); and others

    2012-03-01

    The high doses of radiation received in the wake of the Chernobyl incident and the atomic bombing of Hiroshima and Nagasaki have been linked to the increased appearance of thyroid cancer in the children living in the vicinity of the site. However, the data gathered on the effect of low doses of radiation on the thyroid remain limited. We have examined the genome wide transcriptional response of a culture of TPC-1 human cell line of papillary thyroid carcinoma origin with a RET/PTC1 translocation to various doses (0.0625, 0.5, and 4 Gy) of X-rays and compared it to response of thyroids with a RET/PTC3 translocation and against wild-type mouse thyroids irradiated with the same doses using Affymetrix microarrays. We have found considerable overlap at a high dose of 4 Gy in both RET/PTC-positive systems but no common genes at 62.5 mGy. In addition, the response of RET/PTC-positive system at all doses was distinct from the response of wild-type thyroids with both systems signaling down different pathways. Analysis of the response of microRNAs in TPC-1 cells revealed a radiation-responsive signature of microRNAs in addition to dose-responsive microRNAs. Our results point to the fact that a low dose of X-rays seems to have a significant proliferative effect on normal thyroids. This observation should be studied further as opposed to its effect on RET/PTC-positive thyroids which was subtle, anti-proliferative and system-dependent.

  13. PTC bitter taste genetic polymorphism, food choices, physical growth in body height and body fat related traits among adolescent girls from Kangra Valley, Himachal Pradesh (India).

    Science.gov (United States)

    Sharma, Krishan; Kaur, Goga Kirandeep

    2014-01-01

    Bitter sensitivity among individuals and ethnic groups is partly due to polymorphic bitter taste receptor genes (TAS2Rs). PTC/PROP bitter taste responsiveness at locus TAS2R38 is a well-established index of individual variation in oral sensation that has been linked with predicting food liking and consumption. Previous studies suggest that the relationship between PTC/PROP and anthropometric traits remains controversial. To explore the role of TAS2R38 locus in taste choices, adolescent growth trend for body height, weight and fat patterning among girls and to evaluate their growth status. Cross-sectional data on 210 girls ranging in age from 11-18 years were collected from Palampur in the Kangra valley of Himachal Pradesh. The proportion of PTC non-tasters was 19.52%. PTC tasters and non-tasters had some differences in their food choices and preferences. More sensitive PTC tasters had a low preference for raw cruciferous vegetables and bitter tasting foods (like bitter gourd) and beverages, while they had higher preference for sweet-tasting foods (p < 0.05). PTC tasters overtook their PTC non-taster counterparts from age 14 through 16 years in having higher mean average skinfold, percentage body fat, fat mass index and fat-free mass index. PTC non-tasters had higher mean stature than tasters through all age groups. PTC tasters had slightly higher mean body weight than tasters at age 11, but in later years the advantage was lost; the total gain among non-tasters through adolescence was higher (78.20%) than tasters (66.92%). PTC thresholds significantly and negatively correlated with body height. TAS2R38 locus seems to have a role in food tastes, choices and preferences. Perceived bitterness of PTC/PROP thresholds were significantly and negatively correlated with body height and fat-free mass. These results, thus, tentatively suggest that the PTC non-taster gene may help in better absorption of calcium than its counter taster allele. Studies on differences in

  14. A lack of premature termination codon read-through efficacy of PTC124 (Ataluren in a diverse array of reporter assays.

    Directory of Open Access Journals (Sweden)

    Stuart P McElroy

    Full Text Available The drug molecule PTC124 (Ataluren has been described as a read-through agent, capable of suppressing premature termination codons (PTCs and restoring functional protein production from genes disrupted by nonsense mutations. Following the discovery of PTC124 there was some controversy regarding its mechanism of action with two reports attributing its activity to an off-target effect on the Firefly luciferase (FLuc reporter used in the development of the molecule. Despite questions remaining as to its mechanism of action, development of PTC124 continued into the clinic and it is being actively pursued as a potential nonsense mutation therapy. To thoroughly test the ability of PTC124 to read through nonsense mutations, we conducted a detailed assessment comparing the efficacy of PTC124 with the classical aminoglycoside antibiotic read-through agent geneticin (G418 across a diverse range of in vitro reporter assays. We can confirm the off-target FLuc activity of PTC124 but found that, while G418 exhibits varying activity in every read-through assay, there is no evidence of activity for PTC124.

  15. An examination of associations between the inability to taste phenylthiocarbamide (PTC) and clinical characteristics and trait markers in first-episode, nonaffective psychotic disorders.

    Science.gov (United States)

    Compton, Michael T; Ionescu, Dawn F; Broussard, Beth; Cristofaro, Sarah L; Johnson, Stephanie; Haggard, Patrick J; Potts, Amy A; Wan, Claire Ramsay; Walker, Elaine F

    2013-08-30

    Research findings are mixed as to whether or not the inability to taste phenylthiocarbamide (PTC) might represent an endophenotypic trait marker for schizophrenia. We hypothesized associations between PTC-tasting status and select clinical characteristics and trait markers in patients with psychotic disorders that, if present, would provide support for the inability to taste PTC as a trait marker. In a first-episode psychosis sample (n=93), we measured PTC tasting, family history of psychosis, age at onset of prodrome and psychosis, severity of positive and negative symptoms, global impairment in functioning, neurological soft signs, and four neurocognitive domains (verbal learning/memory, visual learning/memory, verbal working memory, and spatial working memory). Associations between PTC-non-tasting and clinical/neurocognitive variables were examined with χ(2) tests and independent samples t tests. Among participants, 67.7% tasted PTC in comparison to a strip of control paper, and 25.8% were non-tasters. Tasters and non-tasters did not show statistically significant differences with respect to family history, age at onset, severity of symptoms, neurological soft signs, or the four neurocognitive domains. In conjunction with other findings, it is unlikely that PTC-non-tasting is a trait marker of schizophrenia, though a conclusive study is warranted. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  16. A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays.

    Science.gov (United States)

    McElroy, Stuart P; Nomura, Toshifumi; Torrie, Leah S; Warbrick, Emma; Gartner, Ulrike; Wood, Gavin; McLean, W H Irwin

    2013-01-01

    The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring functional protein production from genes disrupted by nonsense mutations. Following the discovery of PTC124 there was some controversy regarding its mechanism of action with two reports attributing its activity to an off-target effect on the Firefly luciferase (FLuc) reporter used in the development of the molecule. Despite questions remaining as to its mechanism of action, development of PTC124 continued into the clinic and it is being actively pursued as a potential nonsense mutation therapy. To thoroughly test the ability of PTC124 to read through nonsense mutations, we conducted a detailed assessment comparing the efficacy of PTC124 with the classical aminoglycoside antibiotic read-through agent geneticin (G418) across a diverse range of in vitro reporter assays. We can confirm the off-target FLuc activity of PTC124 but found that, while G418 exhibits varying activity in every read-through assay, there is no evidence of activity for PTC124.

  17. Corporate Blogging For Dummies

    CERN Document Server

    Karr, Douglas

    2010-01-01

    Establish a successful corporate blog to reach your customers. Corporate blogs require careful planning and attention to legal and corporate policies in order for them to be productive and effective. This fun, friendly, and practical guide walks you through using blogging as a first line of communication to customers and explains how to protect your company and employees through privacy, disclosure, and moderation policies. Blogging guru Douglas Karr demonstrates how blogs are an ideal way to offer a conversational and approachable relationship with customers. You'll discover how to prepare, e

  18. Strategic corporate sustainability

    DEFF Research Database (Denmark)

    Grewatsch, Sylvia; Rohrbeck, René; Madsen, Henning

    This paper aims to advance the understanding of the circumstances under which corporate sustainability (CS) pays off. On the basis of a review of 129 major papers from both the sustainability and general management literature, we discuss the development of the research field. In addition we discuss...... antecedents and outcomes. To overcome this limitation we propose an integrated typology which may facilitate more research on the link between corporate sustainability performance (CSP) and corporate financial performance (CFP). Our expectation is that the strategy type might play a moderating or mediating...

  19. Corporate Social Behaviour

    DEFF Research Database (Denmark)

    Neergaard, Peter; Rahbek Pedersen, Esben

    2003-01-01

    , human rights and environmental protection. Without a common point of reference in national regulation, managers in multinational enterprises now have to develop their own codes of corporate social behaviour. This has created a growing market for private standards within the field of environmental...... management systems, social accountability, corporate citizenship, occupational health and safety and so forth. However, both the idea of government regulation and the literature acclaiming corporate self-regulation should be met with some scepticism. This paper offers a short assessment of the potentials...

  20. Strategic corporate sustainability

    DEFF Research Database (Denmark)

    Grewatsch, Sylvia; Rohrbeck, René; Madsen, Henning

    This paper aims to advance the understanding of the circumstances under which corporate sustainability (CS) pays off. On the basis of a review of 129 major papers from both the sustainability and general management literature, we discuss the development of the research field. In addition we discuss...... antecedents and outcomes. To overcome this limitation we propose an integrated typology which may facilitate more research on the link between corporate sustainability performance (CSP) and corporate financial performance (CFP). Our expectation is that the strategy type might play a moderating or mediating...

  1. Corporate Features and Faith-Based Academies

    Science.gov (United States)

    Green, Elizabeth

    2009-01-01

    This article forms an introductory exploration into the relationship between corporate features and religious values in Academies sponsored by a Christian foundation. This is a theme which arose from research comprising the ethnography of a City Technology College (CTC) with a Christian ethos. The Christian foundation which sponsors the CTC also…

  2. Prevalence of RET/PTC expression in papillary thyroid carcinoma and its correlation with prognostic factors in a north Indian population.

    Science.gov (United States)

    Mishra, A; Agrawal, V; Krishnani, N; Mishra, S K

    2009-01-01

    The prevalence of Rearranged during Transfection/Papillary Thyroid Carcinoma (RET/PTC) rearrangement in papillary thyroid carcinoma (PTC) varies in different geographic regions and its prognostic significance remains unclear. The aim of this study was to recognize the prevalence of RET/PTC expression in PTC from the endemically iodine-deficient region in Northern India and to correlate the expression with the clinicopathologic prognostic factors. Retrospective. Archival tissue used. Immunohistochemistry was performed to look for activated RET protein expression in 50 cases of PTC. No patient had any history of prior irradiation. Chi-square method, Student t test, and binary regression method. A P value of PTC (47.5%), followed by tumors with poorly differentiated areas (25%) and follicular variant (16.7%). RET expression was more prevalent in young patients (45.5 vs. 35.3%), females (43.3 vs. 40.0%), small tumors (33.3 vs. 26.7%), multicentric tumors (36.8 vs. 33.3%), tumors with extrathyroidal invasion (38.9 vs. 32.4%), and regional lymphadenopathy (55.2 vs. 22.2%), while it was less in cases with distant metastases (20 vs. 43.9%). There was no significant correlation of immunoreactivity with any prognostic factor. However, when the cases having immunoreactivity within histiocytes (n=26) and histiocytes + tumor tissue (n=28) were considered, then the expression was significantly more in cases with lymphadenopathy (P values=.009, in both instances). However, the exact clinical significance of RET/PTC positive histiocytes remained unexplained. Prevalence of RET/PTC in our study was consistent with the reported prevalence from other geographic areas. There was no significant correlation with the clinicopathologic factors. However, uniform techniques of detection and large international collaborative studies could clear the uncertainties regarding the prognostic importance of RET/PTC.

  3. 78 FR 52982 - Experian, Experian US Headquarters: Corporate Departments (Finance, HRMD, Contracts, Corporate...

    Science.gov (United States)

    2013-08-27

    ... Employment and Training Administration Experian, Experian US Headquarters: Corporate Departments (Finance...), Experian, Experian US Headquarters: Corporate Departments (finance, HRMD, Contracts, Corporate Marketing...: Corporate Departments (finance, HRMD, Contracts, Corporate Marketing, Global Corporate Systems, Legal...

  4. Promotion effect of manganese oxide on the electrocatalytic activity of Pt/C for methanol oxidation in acid medium

    Energy Technology Data Exchange (ETDEWEB)

    Abdel Hameed, R.M., E-mail: randa311eg@yahoo.com [Chemistry Department, Faculty of Science, Cairo University, Giza (Egypt); Fetohi, Amani E.; Amin, R.S.; El-Khatib, K.M. [Chemical Engineering Department, National Research Center, Dokki, Giza (Egypt)

    2015-12-30

    Graphical abstract: Physical and electrochemical properties of Pt/C, Pt–MnO{sub 2}/C-1 and Pt–MnO{sub 2}/C-2 electrocatalysts. - Highlights: • Adding MnO{sub 2} to Pt/C improved the dispersion of Pt nanoparticles. • The existence of MnO{sub 2} improved the kinetics of methanol oxidation reaction. • R{sub ct} value of Pt–MnO{sub 2}/C was about 10 times as low as that at Pt/C. • The removal of CO{sub ads} poisoning species was facilitated at Pt–MnO{sub 2}/C. - Abstract: The modification of Pt/C by incorporating metal oxides for electrocatalytic oxidation of methanol has gained major attention because of the efficiency loss during the course of long-time operation. This work describes the preparation of Pt–MnO{sub 2}/C electrocatalysts through a chemical route using ethylene glycol or a mixture of ethylene glycol and sodium borohydride as a reducing agent. The crystallite structure and particle size of synthesized electrocatalysts are determined using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The addition of MnO{sub 2} improves the dispersion of Pt nanoparticles. The electrocatalytic activity of Pt–MnO{sub 2}/C towards methanol oxidation in H{sub 2}SO{sub 4} solution is investigated using cyclic voltammetry and electrochemical impedance spectroscopy. The onset potential value of methanol oxidation peak is negatively shifted by 169 mV when MnO{sub 2} is introduced to Pt/C. Moreover, the charge transfer resistance value at Pt–MnO{sub 2}/C is about 10 times as low as that at Pt/C. Chronoamperometry and chronopotentiometry show that CO tolerance is greatly improved at Pt–MnO{sub 2}/C. The increased electrocatalytic activity and enhanced ability to clean platinum surface elect manganese oxide as a suitable promoter for the anode performance in direct methanol fuel cells (DMFCs).

  5. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Kampf, Constance

    2007-01-01

    Understanding Corporate Social Responsibility (CSR) as having explicit policies and implicit norms situated in cultural systems highlights the connections between institutional and cultural structures of nation states and business' commitment to CSR as reflected in the strategies used to communic...

  6. Corporate Social Responsibility

    National Research Council Canada - National Science Library

    Suhaimi Ishak; Mohamad Naimi Mohamad Nor

    2017-01-01

    .... In Malaysia, based on the Malaysian Code on Corporate Governance (MCCG), (2007; 2012) clearly stated the role and responsibility of the board of directors toward the risk management activities...

  7. The corporate security professional

    DEFF Research Database (Denmark)

    Petersen, Karen Lund

    2013-01-01

    In our age of globalization and complex threat environments, every business is called upon to manage security. This tendency is reflected in the fact that a wide range of businesses increasingly think about security in broad terms and strive to translate national security concerns into corporate...... speech. This article argues that the profession of the security manager has become central for understanding how the relationship between national and corporate security is currently negotiated. The national security background of most private sector security managers makes the corporate security...... professional inside the company a powerful hybrid agent. By zooming in on the profession and the practice of national security inside companies, the article raises questions about where to draw the line between corporate security and national security along with the political consequences of the constitution...

  8. Measuring Corporate Sustainability Performance

    Directory of Open Access Journals (Sweden)

    Eugen Nicolăescu

    2015-01-01

    Full Text Available The aim of the present study is to examine and evaluate the evolving character of sustainability management in corporations, the significance of environmental protection and sustainability, and barriers to carrying out an incorporated and strategic firm-wide advance of social responsibility. In the present paper, we focus on the contribution of sustainability undertakings towards enhancing corporate performance, the financial involvements of sustainability position and operation, and the chief function of values in corporate policy. Our paper contributes to the literature by supplying proof of elements that lead to the triumph of business patterns for sustainable development, processes through which stakeholders are affecting corporate sustainability conduct, and the link between economic growth and the environment.

  9. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Kampf, Constance

    2007-01-01

    Understanding Corporate Social Responsibility (CSR) as having explicit policies and implicit norms situated in cultural systems highlights the connections between institutional and cultural structures of nation states and business' commitment to CSR as reflected in the strategies used...

  10. Corporate Governance and Shareholder Litigation

    OpenAIRE

    Kalchev, Georgi

    2009-01-01

    The probability for shareholder litigation is studied and how corporate governance characteristics and other factors explain it. Shareholder litigation results from failure of corporate governance. Thus a better quality of corporate governance is hypothesized to decrease the litigation probability. Corporate governance index is constructed based on principal components. It is found to be a significant predictor of shareholder litigation.

  11. Corporate risk management : an overview

    NARCIS (Netherlands)

    Oosterhof, Casper M.

    2001-01-01

    Corporate risk management and hedging are important activities within financial as well as non-financial corporations. Under the assumptions of Modigliani and Miller [1958], corporate risk management is a redundant activity. However, the existence of market imperfections can explain the corporate us

  12. Corporate Governance Country Assessment : Brazil

    OpenAIRE

    World Bank

    2005-01-01

    This report assesses Brazil's corporate governance policy framework. It highlights recent improvements in corporate governance regulation, makes policy recommendations, and provides investors with a benchmark against which to measure corporate governance in Brazil. It is an update of the 2005 corporate governance Report on the Observance of Standards and Codes (ROSC). Brazil's experience o...

  13. Tax planning in corporation

    OpenAIRE

    Nevodnicheva, Yulia

    2010-01-01

    This thesis "Tax planning in corporation" puts brain to legal entity income tax and it is looking for possible solutions in tax planning in corporation. The first part deals with the tax theory, the other part is the theory of tax planning, comparison of tax regimes and tax policy and tax revenue by optimizing both internationally and in the local aspect. The last part discusses options for optimizing tax

  14. China Petrochemical Corporation

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    China Petrochemical Corporation (Sinopec Group) is a super-large petroleum and petrochemical enterprise group, established in July 1998 on the basis of the former China Petrochemical Corporation. Sinopec Group is a state-owned company solely invested by the state, function ing as a state-authorized investment organization in which the state holds the controlling share. Headquartered in Beijing, Sinopec Group has a registered capital of 182 billion yuan. The board chairman of Sinopec Group is its legal representative.

  15. The Corporations Act 2001

    OpenAIRE

    Bostock, Tom

    2002-01-01

    The author outlines reforms made in Australia in the area of company law with an analysis of the Corporations Act 2001, which along with the Australian Securities and Investments Commission Act 2001 comprises Corporations legislation in Australia. Article by Tom Bostock (a partner in the law firm Mallesons Stephen Jaques, Melbourne, Australia). Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by...

  16. A Detailed Strategy for Managing Corporation Cyber War Security

    Directory of Open Access Journals (Sweden)

    Walid Al-Ahmad

    2015-05-01

    Full Text Available Modern corporations depend heavily on information and communication technologies and are becoming increasingly interconnected locally and internationally. This interconnectedness and dependency on information technology make corporations vulnerable to cyber attacks. Corporate managers therefore need to understand the growing cyber war threats and implement appropriate strategies to mitigate the risks. This research work is an attempt to develop a generic and detailed strategy to assist corporations in managing the cyber war security. The implementation of such a strategy will definitely lead to a more secure business environment and as a result will attract foreign investments to the Arab countries in the Middle East. Such a strategy can be considered as a first step toward protecting corporations from cyber war threats in an effective manner.

  17. Corporate Risk Disclosure and Corporate Governance

    Directory of Open Access Journals (Sweden)

    Kaouthar Lajili

    2009-12-01

    Full Text Available To date, research which integrates corporate governance and risk management has been limited. Yet, risk exposure and management are increasingly becoming the core function of modern business enterprises in various sectors and industries domestically and globally. Risk identification and management are crucial in any business strategy design and implementation. From the investors’ point of view, knowledge of the risk profile, risk appetite and risk management are key elements in making sound portfolio investment decisions. This paper examines the relationships between corporate governance mechanisms and risk disclosure behavior using a sample of Canadian publicly-traded companies (TSX 230. Results show that Canadian public companies are more likely to disclose risk management information over and above the mandatory risk disclosures, if they are larger in size and if their boards of directors have more independent members. Minority voting control ownership structures appear to negatively impact risk disclosure and CEO incentive compensation shows mixed results. The paper concludes that more research is needed to further assess the impact of various governance mechanisms on corporate risk management and disclosure behavior.

  18. 企业绿色技术创新驱动绿色发展探析%The Exploration of Corporate Green Technology Innovation Drive Green Development

    Institute of Scientific and Technical Information of China (English)

    王旭; 秦书生; 王宽

    2014-01-01

    文章基于党的十八大提出的大力推进生态文明建设战略,从推进绿色发展加快生态文明建设的思路出发,对企业绿色技术驱动绿色发展问题进行了研究。文章运用宏观与微观相结合、理论和实践相统一的研究方法,在阐明了企业绿色技术创新是推进绿色发展的必然选择的基础上,从宏观和微观两个层面提出了绿色技术创新驱动绿色发展的途径和方法。从微观层面指出了企业绿色技术创新驱动绿色发展的基本途径,即企业在生产方式上,要通过开发利用绿色技术,建造绿色企业,发展绿色生产等措施以实现企业绿色技术创新;在技术运用上,要大力开发清洁生产技术和资源化技术,以推进企业绿色技术创新成果转化;从宏观层面给出了企业绿色技术创新驱动绿色发展的对策建议,即在宏观保障上,积极建构有利于企业绿色技术创新的社会舆论、政策制度和市场体系,以保障企业绿色技术驱动绿色发展的实施。%This paper based on the strategy to promote the construction of ecological civilization which is proposed at the 18th congress of the Chinese communist party. The paper from the idea of promoting green development to accelerate the construction of ecological civilization aimed at searching green technology drive green development method. The paper trying to analysis enterprise green technology innovation is the inevitable choice to promote green development using the researching method with combine the macro and micro, theory and practice level. From the micro level, in order to achieve enterprise green technology innovation the basic method measures are as follows: firstly, at the mode of production, developing green technology, building green enterprise and develop green production. Secondly, at the technology using, develop clean production technologies, research resources technology which is trying to

  19. 接枝炭黑/聚乙烯导电复合材料正电阻温度系数(PTC)效应研究%Study on PTC Characteristics in Grafting Carbon Black/Polyethylene Conductive Composites

    Institute of Scientific and Technical Information of China (English)

    李勇; 路庆华

    2001-01-01

    用接枝炭黑作导电粒子研究了在聚乙烯基材中的正(电阻)温度系数(PTC)效应。结果发现,甲基丙烯酸甲酯接枝的炭黑在高密度聚乙烯中能表现出较好的PTC效应。从实验现象分析,接枝炭黑的PTC效应是结晶熔融和体积膨胀双重变化共同作用的结果。%Composites based on grafting carbon black/polyethylene were prepared to study the positivetemperature coefficients properties. The effects of various grafting CB for conductive particles in the PTCcomposites were investigated. It showed that PTC properties of MMA-g-CB/HDPE composites were im-proved. The mechanism of PTC effects in the grafting carbon black/polyethylene are the results of crystalmelting and volume expandsion.

  20. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  1. Capabilities and Testing of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2007-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, is currently undergoing testing in the Early Flight Fission Test Facility (EFF-TF). Sodium potassium (NaK), which was used in the SNAP-10A fission reactor, was selected as the primary coolant. Basic circuit components include: simulated reactor core, NaK to gas heat exchanger, electromagnetic (EM) liquid metal pump, liquid metal flowmeter, load/drain reservoir, expansion reservoir, test section, and instrumentation. Operation of the circuit is based around a 37-pin partial-array core (pin and flow path dimensions are the same as those in a full core), designed to operate at 33 kWt. NaK flow rates of greater than 1 kg/sec may be achieved, depending upon the power applied to the EM pump. The heat exchanger provides for the removal of thermal energy from the circuit, simulating the presence of an energy conversion system. The presence of the test section increases the versatility of the circuit. A second liquid metal pump, an energy conversion system, and highly instrumented thermal simulators are all being considered for inclusion within the test section. This paper summarizes the capabilities and ongoing testing of the Fission Surface Power Primary Test Circuit (FSP-PTC).

  2. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  3. Enhancement of anodic oxidation of formic acid on palladium decorated Pt/C catalyst

    Science.gov (United States)

    Wu, Yan Ni; Liao, Shi Jun; Su, Yun Lan; Zeng, Jian Huang; Dang, Dai

    A palladium decorated Pt/C catalyst, Pt@Pd/C, is prepared by a colloidal approach with a small amount of platinum as core. It is found that the catalyst shows excellent activity towards anodic oxidation of formic acid at room temperature and its activity is 60% higher than that of Pd/C. Decoration of palladium shell on the platinum core is supported by XPS results. Due to the use of platinum as core, active components are dispersed very well and the particle sizes are smaller than those of Pd/C. The cyclic voltammetry measurement clearly shows synthetic electro-oxidation effects of formic acid on Pt@Pd/C. It is speculated that the high performance of Pt@Pd/C may result from the unique core-shell structure and synergistic effect of Pt and Pd at the interface. The preparation method for Pt@Pd/C reported in this work will provide additional options for the design of catalysts for direct formic acid fuel cell (DFAFC).

  4. Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

    Directory of Open Access Journals (Sweden)

    Arnold Bolomsky

    2016-03-01

    Full Text Available Abstract Background The polycomb complex protein BMI-1 (BMI-1 is a putative oncogene reported to be overexpressed in multiple myeloma (MM. Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, we investigated PTC-209, a novel small molecule inhibitor of BMI-1, for its activity in MM. Methods BMI-1 expression was analysed in human MM cell lines and primary MM cells by using publically available gene expression profiling (GEP data. The anti-MM activity of PTC-209 was investigated by viability testing, cell cycle analysis, annexin V and 7-AAD staining, quantification of cleaved poly(ADP-ribose polymerase (PARP, JC-1 as well as colony formation assays. Deregulation of central myeloma growth and survival genes was studied by quantitative PCR and flow cytometry, respectively. In addition, the impact of PTC-209 on in vitro osteoclast, osteoblast and tube formation was analysed. Results We confirmed overexpression of BMI-1 in MM patients by using publically available GEP datasets. Of note, BMI-1 expression was further increased at relapse which translated into significantly shorter overall survival in relapsed/refractory patients treated with bortezomib or dexamethasone. Treatment with PTC-209 significantly decreased viable cell numbers in human MM cell lines, induced a G1 cell cycle arrest, promoted apoptosis and demonstrated synergistic activity with pomalidomide and carfilzomib. The anti-MM activity of PTC-209 was accompanied by a significant decrease of cyclin D1 (CCND1 and v-myc avian myelocytomatosis viral oncogene homolog (MYC expression as well as upregulation of cyclin-dependent kinase inhibitor 1A (CDKN1A and cyclin-dependent kinase inhibitor 1B (CDKN1B. We also observed upregulation of NOXA (up to 3.6 ± 1.2-fold induction, P = 0.009 and subsequent downregulation of myeloid cell leukemia 1 (MCL-1 protein levels, which likely

  5. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

    OpenAIRE

    Occhi, Gianluca; Barollo, Susi; Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco

    2015-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expressio...

  6. Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning.

    Science.gov (United States)

    Hammond, Katherine L; Whitfield, Tanya T

    2009-09-01

    In zebrafish, Hedgehog (Hh) signalling is required to specify posterior otic identity. This presents a conundrum, as the nearest source of Hh to the developing inner ear is the ventral midline, in the notochord and floorplate. How can a source of Hh that is ostensibly constant with respect to the anteroposterior axis of the otic vesicle specify posterior otic identity? One possibility is that localised inhibition of Hh signalling is involved. Here we show that genes coding for three inhibitors of Hh signalling, su(fu), dzip1 and hip, are expressed in and around the developing otic vesicle. su(fu) and dzip1 are ubiquitously expressed and unaffected by Hh levels. The expression of hip, however, is positively regulated by Hh signalling and has a complex, dynamic pattern. It is detectable in the neural tube, otic vesicle, statoacoustic ganglion, brain, fin buds, mouth, somites, pronephros and branchial arches. These expression domains bear some similarity, but are not identical, to those of ptc1, a Hh receptor gene that is also positively regulated by Hh signalling. In the neural tube, for instance, hip is expressed in a subset of the ptc1 expression domain, while in other regions, including the otic vesicle, hip and ptc1 expression domains differ. Significantly, we find that initial expression of hip is higher in and adjacent to anterior otic regions, while ptc1 expression becomes progressively restricted to the posterior of the ear. Hip-mediated inhibition of Hh signalling may therefore be important in restricting the effects of Hh to posterior regions of the developing inner ear.

  7. Army Business Transformation: The Utility of Using Corporate Business Models within the Institutional Army

    National Research Council Canada - National Science Library

    Bailer, Jr., John J

    2007-01-01

    .... Through a survey of the literature of published corporate business plans and models, military reports, Army depot case studies, and comparative analysis of emerging computer software technology...

  8. Characteristics and Applied Limits for the Test Code ASME PTC 6.2 of Steam Turbine Performance%汽轮机性能试验规程ASME PTC6.2的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    刘利; 张敏

    2011-01-01

    对美国机械工程师学会制定的试验规程ASME PTC 6.2中蒸汽轮机的试验特点和试验方法等(联合循环)进行了系统阐述.ASME PTC 6.2规程具有边界条件、二元加法修正法等特点,适用于各种形式联合循环中汽轮机性能试验.将ASME PTC 6.2、ASME PTC 6和ASME PTC 46规程进行了比较分析,指出了规程的适用范围,得出了相关结论.

  9. Identification of a PTC-containing DlRan transcript and its differential expression during somatic embryogenesis in Dimocarpus longan.

    Science.gov (United States)

    Fang, Zhi-Zhen; Lai, Cheng-Chun; Zhang, Ya-Ling; Lin, Yu-Ling; Lai, Zhong-Xiong

    2013-10-15

    RAN (Ras-related nuclear protein) plays crucial roles in multiple cellular processes in yeast, animals and plants. Here we present a DlRan gene and its alternative splicing transcripts containing premature terminator codons (PTCs), identified from embryogenic cultures in longan. Multiple alignment and splicing pattern analyses indicated that DlRan-1 transcript harboring PTC was the consequence of alternative splicing. The accumulation of DlRan PTC-containing transcripts increased significantly when the embryogenic calli were treated with the translation inhibitor, cycloheximide, indicating that DlRan-1 may be targeted by NMD. The analysis of expression profiles of DlRan transcripts revealed that differential expression levels of the alternative spliced DlRan transcripts occurred during the development of embryogenic callus, globular-shaped embryos, and cotyledon-shaped embryos, respectively, in the longan somatic embryogenesis, and were in consistent with the embryo development in corresponding wild-type transcripts. The present work offers evidence to speculate that the alternatively spliced PTC-containing transcripts can be functional and may shed light on expression regulation of DlRan during development of the longan somatic embryos. © 2013 Elsevier B.V. All rights reserved.

  10. Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.

    Science.gov (United States)

    Bolze, Florian; Mocek, Sabine; Zimmermann, Anika; Klingenspor, Martin

    2017-04-21

    In rare cases, monogenetic obesity is caused by nonsense mutations in genes regulating energy balance. A key factor herein is the leptin receptor. Here, we focus on leptin receptor nonsense variants causing obesity, namely the human W31X, murine Y333X and rat Y763X mutations, and explored their susceptibilities to aminoglycoside and PTC124 mediated translational read-through in vitro. In a luciferase based assay, all mutations - when analysed within the mouse receptor - were prone to aminoglycoside mediated nonsense suppression with the highest susceptibility for W31X, followed by Y763X and Y333X. For the latter, the corresponding rodent models appear valuable for in vivo experiments. When W31X was studied in the human receptor, its superior read-through susceptibility - initially observed in the mouse receptor - was eliminated, likely due to the different nucleotide context surrounding the mutation in the two orthologues. The impact of the surrounding context on the read-through opens the possibility to discover novel sequence elements influencing nonsense suppression. As an alternative to toxic aminoglycosides, PTC124 was indicated as a superior nonsense suppressor but inconsistent data concerning its read-through activity are reported. PTC124 failed to rescue W31X as well as different nonsense mutated luciferase reporters, thus, challenging its ability to induce translational read-through.

  11. The correlation between BRAF mutations, RET/PTC rearrangements and platelet-derived growth factor B expression in papillary thyroid carcinomas

    Institute of Scientific and Technical Information of China (English)

    王萍

    2013-01-01

    Objective To investigate the prevalence of BRAF T1799A mutation and RET/PTC rearrangement in Qingdao and detect the expression of platelet-derived growth factor B(PDGF-B) in order to investigate the correlation

  12. Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance.

    Science.gov (United States)

    Moberg, Paul J; McGue, Colleen; Kanes, Stephen J; Roalf, David R; Balderston, Catherine C; Gur, Raquel E; Kohler, Christian G; Turetsky, Bruce I

    2007-02-01

    The inability to taste phenylthiocarbamide (PTC; "taste-blindness") has been associated with a number of medical and neurological illnesses not typically related to taste. We examined PTC sensitivity in 67 schizophrenia patients, 30 healthy controls, and 30 first-degree relatives to determine whether taster status could represent a simple vulnerability marker. A higher prevalence of non-tasters was seen in patients and family members relative to healthy controls. Among patients, non-tasters exhibited increased levels of negative and first-rank symptoms as well as poorer right nostril odor identification skills relative to PTC tasters. These differences were not explained by age, sex, education, smoking, or intensity differences. Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles.

  13. Innovation activity of corporations in emerging economies

    Directory of Open Access Journals (Sweden)

    Soboleva Ekaterina N.

    2016-01-01

    Full Text Available The paper considers macro parameters of corporation innovation activity in the BRICS countries. The authors determine transnational corporation behavior strategies in the context of creating and transferring new knowledge, where developed countries (the USA, European countries and Japan play an important role and take a leading position in this process. Companies from emerging economies focus on using and adopting innovations. The reason for this is that knowledge “is coded” specifically, consequently the participants of its exchange have to be in similar intellectual space. Nevertheless, the market-leading corporations from the BRICS countries join the world chains of innovation creation, building their networks to satisfy their branches needs concerning technological decisions and personnel training

  14. Corporate Strategy And The Social Networking Phenomena

    Directory of Open Access Journals (Sweden)

    Robert L. Johnson

    2011-11-01

    Full Text Available The Social Networking (SN phenomena has developed relatively overnight and is continuing to develop at an exponential pace. It allows for innovative new methods of disseminating and collecting information in ways never before dreamed possible by corporate executives. The rise of Social Networking is becoming a disruptive technology for traditional marketing and advertising medium such as radio, television, web page, and print media, creating new business opportunities for the entrepreneur within organizations of any size, and allowing lucrative treasure troves of corporate intelligence about how the customers feel about one’s or a competitor’s products or services. It means new executive leadership skills are now needed to take advantage of these new tools and developing corporate strategies. Those that do this well will be the winners in the market five years from now.

  15. Benefícios do uso de tecnologia de informação para o desempenho empresarial Benefits from the use of information technology for corporate performance

    Directory of Open Access Journals (Sweden)

    Alberto Luiz Albertin

    2008-04-01

    Full Text Available A tecnologia de informação (TI é um dos componentes mais importantes do ambiente empresarial atual, oferecendo grandes oportunidades para as empresas que têm sucesso no aproveitamento de seus benefícios. Este artigo apresenta as dimensões do uso de TI e a relação entre os benefícios oferecidos pelo uso de TI e o desempenho empresarial, tendo como base a estrutura de benefícios de TI no desempenho empresarial. A metodologia utilizada é o estudo de caso numa empresa líder de seu setor, com investimento significativo em TI e que, a partir do estudo, passou a utilizar tal instrumento para a avaliação e acompanhamento dos gastos e investimentos nessa tecnologia. A contribuição do artigo é a identificação dos benefícios oferecidos pela TI e a relação com o desempenho empresarial, fornecendo subsídios importantes para a sua administração.Information technology (IT has been considered one of the most important components in the current business environment, offering opportunities for companies that successfully take advantage of its benefits. The main purpose of this article is to present the IT usage dimensions and the relationship between the benefits offered by using information technology and business performance, based on the structure of its benefits in business performance. The used methodology is a case study in a leading company that has a significant IT investment, and which, as a result of this study, started using this tool for evaluating and monitoring its costs and investments in this technology. The contribution is the identification of the benefits offered by the use of IT and the relationship with business performance, offering important insights to its management.

  16. Advanced stimulation technology deployment program: Unocal Corporation, Dakota and Mesaverde formations, Rincon Unit, San Juan Basin. Topical report, June 1995-February 1996

    Energy Technology Data Exchange (ETDEWEB)

    Wright, C.A.; Weijers, L.; Minner, W.A.

    1996-06-01

    Pinnacle Technologies successfully deployed AST to numerous engineers from Unocal. Unocal estimated an 11% reduction in completion costs after implementing AST on their hydraulic fracture treatments in the Rincon Unit, New Mexico, resulting in a total cost savings of $850,000 on 25 wells. Despite the poorer geology of the newly completed wells, well productivity was equivalent to the older wells with `conventional` fracture treatment designs. Pressure build-up tests also confirmed the improved fracture treatment results: propped fractures of AST-treatments appeared at least twice as long as fractures from conventional treatments, even though completion costs have been reduced.

  17. APL: a corporate strategy.

    Science.gov (United States)

    Fox, J; Nyatanga, L; Ringer, C; Greaves, J

    1992-06-01

    This paper is based on, and summarises, papers read at the second annual international conference of Nurse Education Tomorrow held at the University of Durham (UK) September 1991. To this end this paper will offer: Some Accreditation of Prior Learning (APL) definition and process as reflected in the literature available. A distinction will be made between APL and Accreditation of Prior Experiential Learning (APEL) although the procedures and processes for assessing them will be shown to be the same. A brief outline of corporate strategy, as it applies to APL, will be given to form the basis for logical demonstration of how Derbyshire Institute of Health and Community Studies has employed such a corporate strategy. Insights developed and gained from APL research currently being undertaken through the college of nursing and midwifery will be used to inform the development and nature of corporate strategy. A flowchart of the operationalisation of the corporate strategy is offered as an integrative summary of how all the APL ideas have had a positive cumulative effect. The paper finishes by highlighting the possible strengths and limitations of APL corporate strategy.

  18. PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model

    Science.gov (United States)

    Du, Ming; Liu, Xiaoli; Welch, Ellen M.; Hirawat, Samit; Peltz, Stuart W.; Bedwell, David M.

    2008-01-01

    Nonsense mutations inactivate gene function and are the underlying cause of a large percentage of the individual cases of many genetic disorders. PTC124 is an orally bioavailable compound that promotes readthrough of premature translation termination codons, suggesting that it may have the potential to treat genetic diseases caused by nonsense mutations. Using a mouse model for cystic fibrosis (CF), we show that s.c. injection or oral administration of PTC124 to Cftr−/− mice expressing a human CFTR-G542X transgene suppressed the G542X nonsense mutation and restored a significant amount of human (h)CFTR protein and function. Translational readthrough of the premature stop codon was demonstrated in this mouse model in two ways. First, immunofluorescence staining showed that PTC124 treatment resulted in the appearance of hCFTR protein at the apical surface of intestinal glands in Cftr−/− hCFTR-G542X mice. In addition, functional assays demonstrated that PTC124 treatment restored 24–29% of the average cAMP-stimulated transepithelial chloride currents observed in wild-type mice. These results indicate that PTC124 can effectively suppress the hCFTR-G542X nonsense mutation in vivo. In light of its oral bioavailability, safety toxicology profile in animal studies, and efficacy with other nonsense alleles, PTC124 has the potential to be an important therapeutic agent for the treatment of inherited diseases caused by nonsense mutations. PMID:18272502

  19. Toward a rationale for the PTC124 (Ataluren) promoted readthrough of premature stop codons: a computational approach and GFP-reporter cell-based assay.

    Science.gov (United States)

    Lentini, Laura; Melfi, Raffaella; Di Leonardo, Aldo; Spinello, Angelo; Barone, Giampaolo; Pace, Andrea; Palumbo Piccionello, Antonio; Pibiri, Ivana

    2014-03-03

    The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in the CF transmembrane regulator (CFTR) gene. PTC124 (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-benzoic acid), also known as Ataluren, is a small molecule that has been suggested to allow PTC readthrough even though its target has yet to be identified. In the lack of a general consensus about its mechanism of action, we experimentally tested the ability of PTC124 to promote the readthrough of premature termination codons by using a new reporter. The reporter vector was based on a plasmid harboring the H2B histone coding sequence fused in frame with the green fluorescent protein (GFP) cDNA, and a TGA stop codon was introduced in the H2B-GFP gene by site-directed mutagenesis. Additionally, an unprecedented computational study on the putative supramolecular interaction between PTC124 and an 11-codon (33-nucleotides) sequence corresponding to a CFTR mRNA fragment containing a central UGA nonsense mutation showed a specific interaction between PTC124 and the UGA codon. Altogether, the H2B-GFP-opal based assay and the molecular dynamics (MD) simulation support the hypothesis that PTC124 is able to promote the specific readthrough of internal TGA premature stop codons.

  20. Corporate governance and liquidity

    DEFF Research Database (Denmark)

    Farooq, Omar; Derrabi, Mohamed; Naciri, Monir

    2012-01-01

    This paper examines the impact of corporate governance mechanisms on liquidity in the MENA region, i.e. Morocco, Egypt, Saudi Arabia, United Arab Emirates, Jordan, Kuwait, and Bahrain. Using turnover as a proxy for liquidity, we document significant difference in liquidity between the pre......- and the post-crisis periods in the MENA region. In addition, our results show that bulk of this reduction in turnover can be explained due to weaknesses of corporate governance mechanisms. For example, that dividend payout ratio and choice of auditors – proxies for agency problems – can explain the entire...... difference in liquidity between the two periods. Furthermore, our results indicate that more than 50% of this difference between the two periods can be explained by operational and informational complexity of a firm – proxy for transparency. We argue that poor corporate governance mechanisms increase...

  1. Corporate dentistry in 2032?

    Science.gov (United States)

    Watson, Michael

    2012-07-01

    During the last 20 years, there has been considerable growth in the number of dental practices owned by corporate bodies. At present, well over 800 practices are owned by such bodies and they employ over 3000 dentists. This paper describes the factors that have led to this growth and explores the advantages and disadvantages of 'corporate' dentistry for patients, dentists, and the dental team. It then considers how and why dental practice may change over the next 20 years and concludes that by 2032 the small one-dentist practice may well be in the past. It is likely that smaller practices will have to work in some form of association if they are to survive. Although their current model is unstable, corporates are likely to adapt to a changing environment. By 2032, in some cases, dentistry may well be taken out of its conventional setting, into supermarkets or a school environment.

  2. Corporate governance and liquidity

    DEFF Research Database (Denmark)

    Farooq, Omar; Derrabi, Mohamed; Naciri, Monir

    2012-01-01

    This paper examines the impact of corporate governance mechanisms on liquidity in the MENA region, i.e. Morocco, Egypt, Saudi Arabia, United Arab Emirates, Jordan, Kuwait, and Bahrain. Using turnover as a proxy for liquidity, we document significant difference in liquidity between the pre......- and the post-crisis periods in the MENA region. In addition, our results show that bulk of this reduction in turnover can be explained due to weaknesses of corporate governance mechanisms. For example, that dividend payout ratio and choice of auditors – proxies for agency problems – can explain the entire...... difference in liquidity between the two periods. Furthermore, our results indicate that more than 50% of this difference between the two periods can be explained by operational and informational complexity of a firm – proxy for transparency. We argue that poor corporate governance mechanisms increase...

  3. Iranian Corporations and Corporate Social Responsibility

    Directory of Open Access Journals (Sweden)

    Hadi Chapardar

    2011-10-01

    Full Text Available Comparative studies have demonstrated that the themes for corporate social responsibility (CSR initiatives are different among nations and geographic regions based on their cultural, political, legal, social, and economic contexts. In this research, which was conducted on 56 corporations from IMI100 (100 Iranian companies with highest annual sales, ranked by Industrial Management Institute or IMI, CSR themes in priority have been identified. Data collected from a semistructured questionnaire and some complementary interviews were analyzed against the results of a reference study over 100 companies from developed countries. The resulted themes, some of which may have several subthemes, were developed in three economic, environmental, and social categories. Beside these qualitative findings, two indices are constructed for indicating the “importance” of and “contribution” to each theme. The results and discussions are supposed to help business leaders, international companies inside Iran, governmental authorities, and researchers to improve CSR discussions and practices in the country where CSR undergoes a less structured platform.

  4. [Dose-Response Dependences for Frequency of RET/PTC Gene Rearrangements in Papillary Thyroid Carcinoma after Irradiation. Simple Pooling Analysis of Molecular Epidemiological Data].

    Science.gov (United States)

    Koterov, A N; Ushenkova, L N; Biryukov, A P

    2016-01-01

    On the basis of all possible publications on the theme included in the previously formed base of sources on molecular epidemiology of RET/PTC rearrangements in thyroid papillary carcinoma a pooled analysis ("simple pooling data") on determination of the dose-effect dependences for RET/PTC frequency in radiogenic carcinomas of various irradiated groups was performed. (They are groups subjected to radiotherapeutic exposure, residents near the Chernobyl nuclear power plant (CNPP) and victims of nuclear bombing). The tendency to Pearson linear correlation (r = 0.746; p = 0.148) between the frequency of RET/PTC and the estimated dose on thyroid in the regions affected by the CNPP accident was revealed. But this tendency was recognized to be random owing to abnormally low values of the indicator for the most contaminated Gomel region. The method tentatively called "case-control" showed reliable differences in thyroid dose values for carcinomas with RET/PTC and without those. The versatility of changes was found: the lack of RET/PTC for radiotherapeutic impacts was associated with higher doses, whereas in case of the CNPP accident and for nuclear bombing victims it was the opposite. Probably, in the first case the "cellular cleaning" phenomenon after exposure to very high doses took place. Search of direct Pearson correlations between average/median thyroid doses on groups and RET/PTC frequency in carcinomas of these groups showed a high reliability for the dose-effect dependences- at the continuous dose scale (for RET/PTC in total and RET/PTC1 respectively: r = 0.830; p = 0.002 and r = 0.906; p = 0.0003); while there was no significant correlation received for RET/PTC3. When using the weighting least square regression analysis (proceeding from the number of carcinomas in samples), the specified regularities remained. Attempts to influence the strength of correlation by exception ofthe data of all the samples connected with the accident on the CNPP did not significantly

  5. Jaarboek corporate governance 2011-2012

    NARCIS (Netherlands)

    Lückerath – Rovers, M.; Bier, B.; Kaptein, M.; Paape, L.

    2011-01-01

    In dit eerste Jaarboek Corporate Governance worden uiteenlopende aspecten van Corporate Governance nader besproken door toonaangevende schrijvers uit verschillende disciplines. Inclusief actuele corporate governance code.

  6. Jaarboek corporate governance 2011-2012

    NARCIS (Netherlands)

    Lückerath – Rovers, M.; Bier, B.; Kaptein, M.; Paape, L.

    2011-01-01

    In dit eerste Jaarboek Corporate Governance worden uiteenlopende aspecten van Corporate Governance nader besproken door toonaangevende schrijvers uit verschillende disciplines. Inclusief actuele corporate governance code.

  7. Corporate Social Responsibility of Multinational Oil Corporations to ...

    African Journals Online (AJOL)

    Corporate Social Responsibility of Multinational Oil Corporations to Host ... adopting partnership strategies as a means of contributing to community development, ... community development partnership (CDPs) initiatives' undertaken by Exxon ...

  8. Study on Science and Technology of Modern Corporate Finance and Traditional Financial Theory%现代财务学的科技特质与传统理财思想研究

    Institute of Scientific and Technical Information of China (English)

    常华兵

    2015-01-01

    The evident deviation has arisen between science and technology of modern corporate finance and traditional fi-nancial theory,which is indifferent principle of righteousness,running wild tool reason,fictitious wealth formation.At the same time of improving precision to make policy,people foremost finance is far away and the requirements of the era of sus-tainable development is going against.We must draw nutrition from soil of traditional financial theory to correct science and technology financial theory,including to reshape the financial ethics,bring ecology and environment into finance accounting system,set up new profit distribution model,the focus of financial theory research and service should be shifted to the real economy.%现代财务学的科技特质与传统理财思想之间已出现了明显分野,表现为“义”原则的淡漠、工具理性的横决、财富形态趋向虚拟化等,在提高了决策精度的同时也让人本财务远离而去,违背了可持续发展的时代要求。修正现代财务学框架,必须从传统理财思想的土壤中汲取营养,包括重塑财务学伦理规范,将生态环境耗费纳入财务核算系统,建立利益分配新模式,财务理论研究和服务的重点应转向实体经济等。

  9. Corporate Identity as a Factor of Corporate Security

    Directory of Open Access Journals (Sweden)

    Elena B. Perelygina

    2011-01-01

    Full Text Available Forming-upof the corporate identity is based on cognitive, affective and conative elements of corporate culture. The group as an entity choosing goals and values ensures a certain response to standards and values of corporate culture within the parameters of its social responsibility. Corporate security as security of community and cooperation acts as a form of organizational and ethical approach to developing socially responsible attitude of government and business.

  10. CORPORATE IDENTITY AS A FACTOR OF CORPORATE SECURITY

    OpenAIRE

    Perelygina, Elena B.

    2011-01-01

    Forming-up of the corporate identity is based on cognitive, affective and conative elements of corporate culture. The group as an entity choosing goals and values ensures a certain response to standards and values of corporate culture within the parameters of its social responsibility. Corporate security as security of community and cooperation acts as a form of organizational and ethical approach to developing socially responsible attitude of government and business.

  11. ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout.

    Science.gov (United States)

    Tuttle, R Michael; Lukes, Yvonne; Onstad, Lynn; Lushnikov, Eugeni; Abrosimov, Alexander; Troshin, Vladislav; Tsyb, Anatoli; Davis, Scott; Kopecky, Kenneth J; Francis, Gary

    2008-08-01

    Ionizing radiation is the strongest risk factor known for the development of thyroid neoplasia. While previous studies have demonstrated a high prevalence of ret/papillary thyroid cancer (PTC) activation in cohorts of patients developing thyroid nodules after childhood exposure to ionizing radiation, no study has directly compared ret/PTC activation with individual estimates of radiation dose to the thyroid. This study combines individual thyroid dosimetry data with molecular analysis of surgically removed thyroid nodules in order to determine if ret/PTC activation in thyroid nodules is associated with increasing estimated radiation dose from Chernobyl. This pilot study included adults and children diagnosed with PTC (n = 76) and children diagnosed with follicular adenomas (n = 24) during May 1986 through December 1999, who were living in the Bryansk Oblast of the Russian Federation at the time of the Chernobyl accident, who had paraffin-embedded thyroid surgical samples available and for whom an individual dose to the thyroid could be estimated. The frequency of ret/PTC activation was determined using RT-PCR analysis. Individual radiation doses to the thyroid were estimated using a semiempirical model, and data were collected by detailed interview, primarily of the participant's mother. ret/PTC oncogene activation was detected in 23.8% (5/21) and 14.5% (8/55) of the childhood and adult PTC cases, respectively, and 8.3% (2/24) of the follicular adenoma cases. No statistically significant differences were noted in age at the time of exposure or diagnosis, gender, latency period, or estimated radiation dose between PTC patients with or without ret/PTC activation. Further, no significant dose-response relationship was detected among PTC patients with ret/PTC activation. Factors other than individual thyroid radiation doses may influence the development and subsequent detection of ret/PTC oncogene activation in radiation related PTC arising in the Bryansk Oblast of the

  12. Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT-3 by thyroid oncogenic kinase RET/PTC

    Directory of Open Access Journals (Sweden)

    Kim Dong Wook

    2008-05-01

    Full Text Available Abstract Background RET/PTC (rearranged in transformation/papillary thyroid carcinomas gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although it has been established that RET/PTC kinase plays a crucial role in intracellular signaling pathways that regulate cellular transformation, growth, and proliferation in thyroid epithelial cells, the upstream signaling that leads to the activation of RET/PTC is largely unknown. Based on the observation of high levels of PLD expression in human papillary thyroid cancer tissues, we investigated whether PLD plays a role in the regulating the RET/PTC-induced STAT3 activation. Methods Cancer tissue samples were obtained from papillary thyroid cancer patients (n = 6. The expression level of PLD was examined using immunohistochemistry and western blotting. Direct interaction between RET/PTC and PLD was analyzed by co-immunoprecipitation assay. PLD activity was assessed by measuring the formation of [3H]phosphatidylbutanol, the product of PLD-mediated transphosphatidylation, in the presence of n-butanol. The transcriptional activity of STAT3 was assessed by m67 luciferase reporter assay. Results In human papillary thyroid cancer, the expression levels of PLD2 protein were higher than those in the corresponding paired normal tissues. PLD and RET/PTC could be co-immunoprecipitated from cells where each protein was over-expressed. In addition, the activation of PLD by pervanadate triggered phosphorylation of tyrosine 705 residue on STAT-3, and its phosphorylation was dramatically higher in TPC-1 cells (from papillary carcinoma that have an endogenous RET/PTC1 than in ARO cells (from anaplastic carcinoma without alteration of total STAT-3 expression. Moreover, the RET/PTC-mediated transcriptional activation of STAT-3 was synergistically increased by over-expression of PLD, whereas the PLD activity as a lipid hydrolyzing enzyme was not affected by RET/PTC

  13. The integration of corporate governance in corporate social responsibility disclosures

    NARCIS (Netherlands)

    Kolk, A.; Pinkse, J.

    2010-01-01

    In recent years, not only has attention to corporate governance increased but also the notion has broadened considerably, and started to cover some aspects traditionally seen as being part of corporate social responsibility (CSR). CSR, corporate governance and their interlink seem particularly relev

  14. The integration of corporate governance in corporate social responsibility disclosures

    NARCIS (Netherlands)

    Kolk, A.; Pinkse, J.

    2010-01-01

    In recent years, not only has attention to corporate governance increased but also the notion has broadened considerably, and started to cover some aspects traditionally seen as being part of corporate social responsibility (CSR). CSR, corporate governance and their interlink seem particularly relev

  15. The integration of corporate governance in corporate social responsibility disclosures

    NARCIS (Netherlands)

    Kolk, A.; Pinkse, J.

    2010-01-01

    In recent years, not only has attention to corporate governance increased but also the notion has broadened considerably, and started to cover some aspects traditionally seen as being part of corporate social responsibility (CSR). CSR, corporate governance and their interlink seem particularly

  16. Hubungan Corporate Governance, Corporate Social Responsibilities dan Corporate Financial Performance Dalam Satu Continuum

    Directory of Open Access Journals (Sweden)

    Etty Murwaningsari

    2009-01-01

    Full Text Available This research aims to identify the influence of Good Corporate Governance, represented by institutional ownership and managerial ownership, on Corporate Social Responsibility and Corporate Financial Performance, and also to observe the possible influence of Corporate Social Responsibility on Corporate Financial Performance. This research examines 126 manufacturing companies which are listed in Indonesian Stock Exchange (ISX and have issued an audited financial statement for 2006. The statistical method used to test the hypothesis is Path Analysis. The result suggests that Good Corporate Governance influences both the disclosure of Corporate Social Responsibility and Corporate Financial Performance and that Corporate Social Responsibility significantly influences Corporate Financial Performance. The result also suggests that CEO Tenure, the controlling variable, holds a significant influence on the disclosure of Corporate Social Responsibility. Yet, there is no strong evidence to support the type of industries as an influencing factor of Corporate Social Responsibility. Furthermore, we found that the latter condition would also apply when we analyze the influence of Corporate Secretary and Nomination and Remuneration Committee on Corporate Financial Performance. Abstract in Bahasa Indonesia: Penelitian ini bertujuan untuk mengidentifikasi pengaruh antara struktur Coorporate Governance yang diproksikan sebagai kepemilikan institusional, kepemilikan manajerial terhadap corporate social responsibility dan corporate social responsibility terhadap corporate financial performance. Penelitian menggunakan data sekunder dari laporan tahunan 2006 perusahaan publik yang terdapat di Pusat Referensi Pasar Modal (PRPM Bursa Efek Indonesia (BEI. Sampel dalam penelitian ini sebanyak 126 perusahaan. Melalui pendekatan analisa jalur (path analysis menunjukkan Good Corporate Governance yaitu kepemilikan managerial dan institusional mempunyai pengaruh terhadap

  17. Corporate Social Responsibility in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    This doctoral dissertation examines the business-development relations in Afghanistan by focusing on Corporate Social Responsibility (CSR) and other related practices from corporations in the Afghan mobile telecommunications industry. More concretely, the study aims to explore the characteristics...

  18. 76 FR 68747 - Hess Corporation

    Science.gov (United States)

    2011-11-07

    ...] Hess Corporation v. PJM Interconnection, L.L.C.; Notice of Petition for Declaratory Order and Complaint... 385.212, Hess Corporation (Complainant) filed a Petition for Declaratory Order requesting that...

  19. Application of the Peroxotitanium Complex (PTC) for Flexible Dye Sensitized Solar Cells (DSSC)%过氧化钛配合物(PTC)体系在柔性染料敏化太阳能电池中的应用

    Institute of Scientific and Technical Information of China (English)

    张阳; 曾庆慧; 只金芳

    2009-01-01

    The anatase TiO_2 sol prepared from Peroxotitanium Complex (PTC) at low temperature was used as the additive for photo-anode of flexible dye sensitized solar cells (DSSC). It is found that the photoelectric performance of DSSC was obviously increased by 50 % with the addition of TiO_2 sol. Furthermore, we investigated the effects of the sol content and reaction time on the pho-toelectric performance. It is proved that there is an optimal addition value for the DSSC application. When the content (volume) of PTC sol is 10% and refluxing time reaches to 9 h, the best photo-electric performance is obtained.%本文利用水性过氧化钛配合物(peoxotitanium complex:PTC)前驱体可低温合成锐钛矿TiO_2溶胶的特性,将其用作柔性染料敏化太阳能电池(DSSC)中的光阳极材料的成膜助剂.研究发现:加入基于PTC制得的TiO_2溶胶可以明显提高DSSC的光电转换性能,在制备DSSC的浆料中加入10%(体积分数)的基于PTC制得的TiO_2溶胶后,电池的光电效率可以提升50%.我们进一步研究了光电转换效率的影响因素,结果表明,溶胶的加入量和反应时间均有一最佳值,当基于PTC的TiO_2溶胶添加量为10%,反应时间为9 h,所得到电池的光电性能最好.

  20. Of Corporate Bondage

    Science.gov (United States)

    Ridgeway, James

    1975-01-01

    "While it is entirely possible that the university will continue to function as an essential arm of the giant agribusiness and energy corporations, there are, nevertheless, a wealth of opportunities for it to direct its energies to more useful purposes." The author traces universities' past involvement noting alternatives in energy and agriculture…

  1. Corporate Stakeholding and Globalism

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2016-01-01

    Most corporations consider their stakeholders to be those, who can be defined in a relatively narrow periphery. Customers, workers, investors, authorities, neighbours, suppliers and various interest groups, for instance NGOs. However, during the last decades, phenomena such as the financial crisis...

  2. Corporate governance through codes

    NARCIS (Netherlands)

    Haxhi, I.; Aguilera, R.V.; Vodosek, M.; den Hartog, D.; McNett, J.M.

    2014-01-01

    The UK's 1992 Cadbury Report defines corporate governance (CG) as the system by which businesses are directed and controlled. CG codes are a set of best practices designed to address deficiencies in the formal contracts and institutions by suggesting prescriptions on the preferred role and compositi

  3. Trends in corporate greening

    DEFF Research Database (Denmark)

    Madsen, Henning; Ulhøi, John Parm

    The concept of corporate environmental management has existed for the last two to three decades. Many companies have fully or partly adopted the concept in their efforts to eliminate or reduce the impacts on the natural environment caused by their business activities. The question is, however, if...

  4. Essential Corporate Bankruptcy Law

    NARCIS (Netherlands)

    Couwenberg, Oscar; Lubben, Stephen J.

    2015-01-01

    This article begins from a simple observation: Chapter 11 of the United States Bankruptcy Code is the global standard for corporate restructuring, but at the same time it is a far more complex procedure than most jurisdictions seem to require. This observation begs the question what parts of a

  5. Corporate Climate Change

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The American Chamber of Commerce, the People's Republic of China (AmCham-China) and the American Chamber of Commerce in Shanghai recently released "American Corporate Experience in a Changing China: Insights From AmCham Business Climate Surveys, 1999-2005." Excerpts of the report follow:

  6. Contractual Corporate Governance

    NARCIS (Netherlands)

    Goergen, M.; Renneboog, L.D.R.

    2008-01-01

    Companies have the choice to deviate from their national corporate governance standards by opting into another system. They can do so via contractual devices – such as cross-border mergers and acquisitions, (re)incorporations, and cross-listings – which enable firms to choose their preferred level

  7. Corporate strategies: organizational structure.

    Science.gov (United States)

    Howe, R C; Oestreicher, V

    1988-06-01

    In previous installments of this series, the authors outlined factors that influence corporation information system strategies. The factor that appears to be most significant is centralization vs. decentralization. This article presents examples of organizational structures, roles and responsibilities for either approach.

  8. Corporate governance through codes

    NARCIS (Netherlands)

    Haxhi, I.; Aguilera, R.V.; Vodosek, M.; den Hartog, D.; McNett, J.M.

    2014-01-01

    The UK's 1992 Cadbury Report defines corporate governance (CG) as the system by which businesses are directed and controlled. CG codes are a set of best practices designed to address deficiencies in the formal contracts and institutions by suggesting prescriptions on the preferred role and

  9. Corporate social responsibility

    OpenAIRE

    Arsić, Zoran

    2011-01-01

    Corporate Social Responsibility (CSR) is a concept whereby companies integrate social and environmental concerns in their business operations and in their interaction with their stakeholders on a voluntary basis. Definition emphasizes three basic characteristics of CSR. CSR is voluntary concept, it covers environmental issues and interaction with stakeholders, not only shareholders, is taken into account.

  10. The Politicization of Corporations

    DEFF Research Database (Denmark)

    Garsten, Christina; Sörbom, Adrienne

    This paper departs from an interest in the involvement of business leaders in the sphere of politics, in the broad sense. At a general level, we are seeing a proliferation of usages of non-market corporate strategies, such as testimony, lobbying, interlocking of positions and other means to influ......This paper departs from an interest in the involvement of business leaders in the sphere of politics, in the broad sense. At a general level, we are seeing a proliferation of usages of non-market corporate strategies, such as testimony, lobbying, interlocking of positions and other means...... to influence policymakers at all levels of government and international institutions as an adjunct to the firm’s market strategies. This paper brings to the fore the role of corporations in the World Economic Forum (WEF), and how firms act through the WEF to advance their interests, financial as well...... as political. What is the role of business in the WEF, and how do business corporations advance their interests through the WEF? Empirically we depart from ethnographic field studies of the World Economic Forum, drawing on observations from WEF-events and interviews with participants and organizers. We propose...

  11. Corporate information management guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    At the request of the Department of Energy`s (DOE) Information Management (IM) Council, IM representatives from nearly all Headquarters (HQ) organizations have been meeting over the past year as the Corporate Guidance Group (CGG) to develop useful and sound corporate information management (IM) guidance. The ability of the Department`s IM community to develop such unified guidance continues to be critical to the success of future Departmental IM planning processes and the establishment of a well-coordinated IM environment between Headquarters and field organizations. This report, with 26 specific corporate IM guidance items documented and unanimously agreed to, as well as 12 items recommended for further development and 3 items deferred for future consideration, represents a highly successful effort by the IM community. The effort has proven that the diverse DOE organizations can put aside individual preferences and work together towards a common and mutually beneficial goal. In examining most areas and issues associated with information management in the Department, they have developed specific, far-reaching, and useful guidance. The IM representatives recommend that the documented guidance items provided in this report and approved by the DOE IM Council be followed by all IM organizations. The representatives also strongly recommend that the guidance process developed by the CGG be the single process for developing corporate IM guidance.

  12. Determination and Analysis on Taste-Blindness Gene Frequency to Phenylthiocarbamide(PTC)%苯硫脲(PTC)味盲基因频率的测定与分析

    Institute of Scientific and Technical Information of China (English)

    赵淑娟; 庞有志; 杨又兵; 郭晓红

    2005-01-01

    目的测定河南省汉族青少年苯硫脲(PTC)味盲基因频率.方法采用阈值法测定219名汉族青少年对PTC的尝味敏感性.结果味盲率为8.22%,味盲基因频率为0.2867,尝味基因频率为0.7133.结论尝味能力与民族、地理位置以及某些疾病有关.

  13. Report from AmSECT’s International Consortium for Evidence-Based Perfusion: American Society of ExtraCorporeal Technology Standards and Guidelines for Perfusion Practice: 2013

    Science.gov (United States)

    Baker, Robert A.; Bronson, Shahna L.; Dickinson, Timothy A.; Fitzgerald, David C.; Likosky, Donald S.; Mellas, Nicholas B.; Shann, Kenneth G.

    2013-01-01

    Abstract: One of the roles of a professional society is to develop standards and guidelines of practice as an instrument to guide safe and effective patient care. The American Society of Extracorporeal Technology (AmSECT) first published its Essentials for Perfusion Practice, Clinical Function: Conduct of Extracorporeal Circulation in 1993. The International Consortium for Evidence-Based Perfusion (ICEBP), a committee within AmSECT, was tasked with updating this document in 2010. The aim of this report is to describe the method of development and content of AmSECT’s new professional standards and guidelines. The ICEBP committee independently evaluated and provided input regarding the current “Essentials and Guidelines.” Structural changes were made to the entire document, and a draft document was developed, presented, and circulated to the AmSECT Board of Directors and broader membership for comment. Informed by these reviews, a revised document was then presented to the Society for a membership vote. The final document consists of 15 areas of practice covered by 50 Standards and 38 Guidelines (see Appendix 1) with the first standard focusing on the development of institutional protocols to support their implementation and use. A majority of the membership voted to accept the document (81.2% of the voting membership accepting, 18.8% rejecting). After an audit of the balloting process by AmSECT’s Ethics Committee, the results were reported to the membership and the document was officially adopted on July 24, 2013. The Standards and Guidelines will serve as a useful guide for cardiac surgical teams that wish to develop institution-specific standards and guidelines to improve the reliability, safety, and effectiveness of adult cardiopulmonary bypass. The ICEBP recognizes that the development of a Standards and Guidelines statement alone will not change care. Safe, reliable, and effective care will be best served through the development and implementation of

  14. Behavioral corporate governance : four empirical studies

    NARCIS (Netherlands)

    van der Laan, G.

    2009-01-01

    This thesis consists of studies of corporate governance from a behavioral perspective. The chapters are about trust between chief executive officers (CEOs) and board chairpersons, asymmetric effects of corporate social responsibility on corporate financial performance, compliance with corporate

  15. Corporal Punishment and the Schools.

    Science.gov (United States)

    Bauer, Gordon B.; And Others

    1990-01-01

    In order to understand and evaluate the continued prevalence of corporal punishment in school systems, this article reviews the following topics: (1) historical issues; (2) current demographics and correlates; (3) the effectiveness of corporal punishment in school settings; (4) myths; (5) alternatives to corporal punishment; and (6) social policy.…

  16. De Ratio van Corporate Governance

    NARCIS (Netherlands)

    A. de Jong (Abe)

    2006-01-01

    textabstractAbe de Jong (1970) is Professor in Corporate Finance and Corporate Governance at RSM Erasmus University. He obtained a PhD in finance at Tilburg University (1999). His research and teaching interests are in the area of empirical corporate finance and include capital structure choice,

  17. Corporate governance and public corruption

    OpenAIRE

    Cusolito, Ana

    2010-01-01

    Corporate governance in the private sector and corruption are important for economic development and private sector development. This paper investigates how corporate governance in private-sector media companies can affect public corruption. The analytical framework, based on models of corporate governance, identifies two channels through which media ownership concentration affects corrupt...

  18. Corporate Governance Country Assessment : Moldova

    OpenAIRE

    World Bank

    2004-01-01

    This report provides an assessment of Moldova's corporate governance framework-its legal and policy framework, as well as enforcement and compliance practices. The report makes policy recommendations where appropriate, and provides investors with a benchmark to compare corporate governance with the 1999 OECD Principles of Corporate Governance. Moldova is beginning to upgrade its legal and ...

  19. UNLIMITED I, On the corporate training revolution

    Directory of Open Access Journals (Sweden)

    Leandro Adolfo Viltard

    2017-09-01

    Full Text Available The unlimited is a borderless territory where the whole world is inmerse. In this study, it is shown that the unlimited is present in education and, specifically, in the corporate educational arena. Helped by technology and automation, disruptive leaders are challenging the way things are done, the way we think and, in addtion, what we are. After performing a documentation analysis, conclusions are that big problems –as education- need cheap and scaled technology; leadership and organizations must evolve to less human intervention; education and training need a rethought; Eduaction-2-Employment (E2E is key for unemployment; and that new educational structures, delivery methods, pedagogical approaches and advanced Learning Management Systems (LMS are observed proposing huge transformations in the corporate educational arena. This is a qualitative investigation with a not experimental and transversal research design.

  20. Iodine regulates G2/M progression induced by CCL21/CCR7 interaction in primary cultures of papillary thyroid cancer cells with RET/PTC expression.

    Science.gov (United States)

    Zhang, You-Yuan; Liu, Ze-Bing; Ye, Xuan-Guang; Ren, Wei-Min

    2016-10-01

    Treatment with high iodine concentrations can delay oncogenic activation effects, reduce cell growth and return thyroid-specific gene and protein expression levels to normal. During rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) 3 activation, excess iodine can act as a protective agent in thyroid follicular cells. The chemokine receptor CCR7 serves a critical role in lymphocyte trafficking into and within lymph nodes, the preferential metastatic site for PTC. However, the potential associations between chemokine (C‑C motif) ligand 21 (CCL21)/C‑C chemokine receptor type 7 (CCR7) interaction and iodine concentrations in primary cultures of PTC with RET/PTC expression remain unclear. Proliferation assays of primary cultures of PTC cells with RET/PTC1 and RET/PTC3 expression indicated that CCR7 activation by its specific ligand, CCL21, was associated with significantly increased cell proliferation. Flow cytometry data indicated that CCL21/CCR7 interaction significantly increased the fraction of cells in the G2/M phase of the cell cycle. Western blotting indicated that CCL21/CCR7 interaction significantly upregulated cyclin A, cyclin B1 and cyclin‑dependent kinase 1 (CDK1) expression. Western blotting determined that CCL21/CCR7 interaction significantly enhanced the levels of phosphorylated extracellular signal‑regulated kinase (P‑ERK). Co-immunoprecipitation confirmed that there was interaction between P‑ERK and cyclin A, cyclin B1 or CDK1, particularly in the presence of CCL21. Sodium iodide (NaI, 10-5 M) significantly abolished the effects of exogenous CCL21. These results suggest that CCL21/CCR7 interaction contributes to G2/M progression of RET/PTC‑expressing cells via the ERK pathway in association with 10‑5 M NaI.

  1. Direct Determination of the Ionization Energies of PtC, PtO, and PtO2 with VUVRadiation

    Energy Technology Data Exchange (ETDEWEB)

    Citir, Murat; Metz, Ricardo B.; Belau, Leonid; Ahmed, Musahid

    2008-07-21

    Photoionization efficiency curves were measured for gas-phase PtC, PtO, and PtO2 using tunable vacuum ultraviolet (VUV) radiation at the Advanced Light Source. The molecules were prepared by laser ablation of a platinum tube, followed by reaction with CH4 or N2O and supersonic expansion. These measurements providethe first directly measured ionization energy for PtC, IE(PtC) = 9.45 +- 0.05 eV. The direct measurement also gives greatly improved ionization energies for the platinum oxides, IE(PtO) = 10.0 +- 0.1 eV and IE(PtO2) = 11.35 +- 0.05 eV. The ionization energy connects the dissociation energies of the neutral and cation, leading to greatly improved 0 K bond dissociation energies for the neutrals: D0(Pt-C) = 5.95 +- 0.07 eV, D0(Pt-O)= 4.30 +- 0.12 eV, and D0(OPt-O) = 4.41 +- 0.13 eV, as well as enthalpies of formation for the gas-phase molecules Delta H0 f,0(PtC(g)) = 701 +- 7 kJ/mol, Delta H0f,0(PtO(g)) = 396 +- 12 kJ/mol, and Delta H0f,0(PtO2(g)) = 218 +- 11 kJ/mol. Much of the error in previous Knudsen cell measurements of platinum oxide bond dissociation energies is due to the use of thermodynamic second law extrapolations. Third law values calculated using statistical mechanical thermodynamic functions are in much better agreement with values obtained from ionization energies and ion energetics. These experiments demonstrate that laser ablation production with direct VUV ionization measurements is a versatile tool to measure ionization energies and bond dissociation energies for catalytically interesting species such as metal oxides and carbides.

  2. Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics.

    Science.gov (United States)

    Pelizzo, M R; Pennelli, G; Zane, M; Galuppini, F; Colletti, P M; Merante Boschin, I; Rubello, D

    2015-08-01

    We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620. This mutation has pathogenetic significance and was considered responsible for the various tumours of the HNPCC spectrum. In particular, in the same kindred, spanning 5 generations, there were 5 members with colorectal cancer, 4 with endometrial cancer, 3 with gastric and 2 with breast cancer. The second case is a 34-year-old man with typical HNPCC syndrome with colonic resection for colon cancer at age 21. The patient underwent total thyroidectomy with central and lateral node dissection in 2010, at age 34, with a histological diagnosis of PTC with nodal metastases (pT4N1b). Molecular genetic analysis showed a germ-line mutation of the MSH2 gene (thymine insertion at position 907). This mutation had pathogenetic significance and was considered responsible for HNPCC development. Two similar cases have been reported: a 39-year-old woman, and a 44-year-old woman, affected by HNPCC syndrome, with anaplastic thyroid carcinoma and undifferentiated thyroid carcinoma, respectively. We reviewed the Lynch syndrome literature on the history, genetics and expanding tumour spectrum of this condition. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  3. Establishment of the system of innovative management of global corporations

    Directory of Open Access Journals (Sweden)

    Yevhen Panchenko

    2011-06-01

    Full Text Available There have been highlighted the relevant issues of system establishment of the innovative management of global corporations and generalized the experience of the leading world corporations in the achievement and keeping leading positions on the highly technological segments of the global market. It shows the significance of the creative personal qualities of managers in the generation and implementation of effective innovative solutions in the global business, grounds the categorical and functional imperatives of the innovative development of global corporations. In the context of formation of the new knowledge economy there were highlighted contradictions and available instruments of reinforcement of leading positions among the leading global corporations in the innovative sphere. There was paid attention to the implementation of the new concepts of global corporations’ leadership of BRIC countries, in particular, Chinese highly technological companies. There has been made a conclusion about global institutionalization of the innovative activity.

  4. Investigations on CERN PSB Beam Dynamics with Strong Direct Space Charge Effects Using the PTC-Orbit Code

    CERN Document Server

    Forte, V; Carli, C; Martini, M; Metral, E; Mikulec, B; Schmidt, F; Molodozhentsev, A

    2013-01-01

    The CERN PS Booster (PSB) has the largest space charge tune spread in the LHC injector chain. As part of the LHC Injectors Upgrade (LIU) project, the machine will be upgraded. Space charge and resonances are serious is- sues for the good quality of the beam at injection energy. Consequently simulations are needed to track the beam in the machine taking into account space charge effects: PTC-ORBIT has been used as tracking code. This paper presents simulation results that are compared with mea-surements for machine performances evaluation and code- benchmarking purposes.

  5. Corporate Social Responsibility in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    This doctoral dissertation examines the business-development relations in Afghanistan by focusing on Corporate Social Responsibility (CSR) and other related practices from corporations in the Afghan mobile telecommunications industry. More concretely, the study aims to explore the characteristics...... provides a relevant empirical focus that can enrich the theoretical debates about CSR in developing countries. The study thereby stresses on the importance of context, and integrates both the societal and corporate dimensions to study CSR by corporations in the Afghan mobile telecommunications industry...... in Afghanistan, and a study of secondary data from the corporations, Afghan state institutions, civil society and other relevant actors....

  6. The Design of Intelligent Corporate E-commerce System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The paper shows how to design and implement an inte ll igent e-commerce system for medium or small enterprises. The corporate intranet is connected with Internet, which constitutes the hardware of the system. The s ystem adopts modern voice-identification technology for user authentication to enable secure access to key databases and thus enhance the security of system da tabases. The software system consists of four modules: 1. Corporate website and advertisement information system, intending for updati...

  7. New Product Development. Engineering and Commerce Students Join Forces with a Corporate Sponsor.

    Science.gov (United States)

    Audet, Josee; Pegna, Joseph

    2001-01-01

    Mechanical engineering and business student teams developed new products using a corporate sponsor's technology in a simulated business setting. Students learned about product development and venture start-up, and the sponsor gained new applications for its patented technology. (SK)

  8. New Product Development. Engineering and Commerce Students Join Forces with a Corporate Sponsor.

    Science.gov (United States)

    Audet, Josee; Pegna, Joseph

    2001-01-01

    Mechanical engineering and business student teams developed new products using a corporate sponsor's technology in a simulated business setting. Students learned about product development and venture start-up, and the sponsor gained new applications for its patented technology. (SK)

  9. PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally

    Science.gov (United States)

    Graci, Jason D.; Jung, Stephen P.; Pichardo, John; Tong, Xiao; Gu, Zhengxian

    2016-01-01

    PTC725 is a small molecule NS4B-targeting inhibitor of hepatitis C virus (HCV) genotype (gt) 1 RNA replication that lacks activity against HCV gt2. We analyzed the Los Alamos HCV sequence database to predict susceptible/resistant HCV gt's according to the prevalence of known resistance-conferring amino acids in the NS4B protein. Our analysis predicted that HCV gt3 would be highly susceptible to the activity of PTC725. Indeed, PTC725 was shown to be active against a gt3 subgenomic replicon with a 50% effective concentration of ∼5 nM. De novo resistance selection identified mutations encoding amino acid substitutions mapping to the first predicted transmembrane region of NS4B, a finding consistent with results for PTC725 and other NS4B-targeting compounds against HCV gt1. This is the first report of the activity of an NS4B targeting compound against HCV gt3. In addition, we have identified previously unreported amino acid substitutions selected by PTC725 treatment which further demonstrate that these compounds target the NS4B first transmembrane region. PMID:27620477

  10. The Risk of Relapse in Papillary Thyroid Cancer (PTC) in the Context of BRAFV600E Mutation Status and Other Prognostic Factors.

    Science.gov (United States)

    Czarniecka, Agnieszka; Kowal, Monika; Rusinek, Dagmara; Krajewska, Jolanta; Jarzab, Michal; Stobiecka, Ewa; Chmielik, Ewa; Zembala-Nozynska, Ewa; Poltorak, Stanislaw; Sacher, Aleksander; Maciejewski, Adam; Zebracka-Gala, Jadwiga; Lange, Dariusz; Oczko-Wojciechowska, Malgorzata; Handkiewicz-Junak, Daria; Jarzab, Barbara

    2015-01-01

    The risk of over-treatment in low-advanced PTC stages has prompted clinicians to search for new reliable prognostic factors. The presence of BRAF mutation, the most frequent molecular event in PTC, seems to be a good candidate. However, there is still lack of randomised trials and its significance has been proved by retrospective analyses, involving a large group of patients. The question arises whether this factor is useful in smaller populations, characterised for specialised centres. Thus, the aim of the study was to evaluate the use of BRAF mutation as a potential predictive marker in PTC patients. 233 PTC subjects treated between 2004-2006, were retrospectively analysed. Stage pT1 was diagnosed in 64.8% patients and lymph node metastases in 30.9%. Median follow-up was 7.5 years. BRAFV600E mutation was assessed postoperatively in all cases. BRAF V600E mutation was found in 54.5%. It was more frequent in patients > 45 years (p=0.0001), and associated with larger tumour size (p=0.004). Patients with tumours PTC recurrence is mainly related to the presence of lymph node metastases and extrathyroidal invasion, whereas no impact of BRAF V600E mutation has been demonstrated.

  11. Corporate volunteering - motivation for voluntary work

    Directory of Open Access Journals (Sweden)

    Debora Azevedo

    2008-07-01

    Full Text Available Nowadays, when the welfare state is a responsibility of the entire society, organizations in the private sector assume co-responsibility for social issues. They are also pressured by the challenges presented by technological advances and the globalization , involving new parameters and requirements for quality. In this context, the concept of Corporate Social Responsibility (RSC emerges as an option for solutions to the issues related to the company and the whole community. Among the actions of the RSC is the Corporate Volunteering-program, which aims to promote / encourage employes to do voluntary work. A central issue when talking about volunteering is the withdrawal of these (SILVA and FEITOSA, 2002; TEODÓSIO, 1999 and, in accordance with the Community Solidarity (1997, one of the possible causes for the withdrawal is the lack of clarity as to the motives and expectations that lead the person to volunteer themselves. This study uses qualitative research and triangulation of feedback from volunteers, coordinators of volunteers and social organizations, to present a framework from which it is possible to analyze the various motivations for the volunteer work. Key words: Corporate Volunteering program. Volunteering. Corporate social responsibility.

  12. Design of Customized Corporate E-Learning

    Directory of Open Access Journals (Sweden)

    Tor Atle Hjeltnes

    2009-10-01

    Full Text Available Today's educational institutions deal increasingly with external commercial organizations in connection with e-learning deliveries. Production and delivery of e-learning to corporations is different from both traditional campus education and online distance education for independent online students. This study discusses challenges related to e-learning production and delivery for corporate customers. Consequently we have identified appropriate guiding principles that should contribute to the specification of amodel for design of customized corporate e-learning. We place particular emphasis on collaboration and stakeholder involvement, formative evaluation, utilization of technological opportunities, and relevant training for all parties involved. Moreover, we propose to benefit from concurrent design principles to achieve effective and efficient multidisciplinary collaboration in the design process. The study is based on primary data from two different projects where an educational institution offers e-learning for external corporate customers. In addition we collect secondary data from available research literature on e-learning and supplementary data from colleagues with long experience in this field.

  13. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Liempd, Dennis van; Warming-Rasmussen, Bent; Abild-Nielsen, Jens

    2007-01-01

    Målet med denne artikel er at klargøre, at der findes forskellige teoretiske tilgange til ansvarlig leverandørstyring og Corporate Social Responsibility (i det følgende kaldt CSR). Endvidere er det målet at belyse, at området er i kraftig udvikling og forventes at få øget betydning for revisor i...... ansvarlig leverandørstyring og CSR. I artiklen konkluderes følgende: - at udviklingen i Corporate Social Responsibility indikerer, at etik er den mest betydende faktor (driver); (jf. afsnit 1)- at etik som primær driver vil betyde, at virksomheden vil gå ud over lovens minimumkrav, og stræbe efter de...

  14. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Liempd, Dennis van; Warming-Rasmussen, Bent; Abild-Nielsen, Jens

    2007-01-01

    Målet med denne artikel er at klargøre, at der findes forskellige teoretiske tilgange til ansvarlig leverandørstyring og Corporate Social Responsibility (i det følgende kaldt CSR). Endvidere er det målet at belyse, at området er i kraftig udvikling og forventes at få øget betydning for revisor i...... ansvarlig leverandørstyring og CSR. I artiklen konkluderes følgende: - at udviklingen i Corporate Social Responsibility indikerer, at etik er den mest betydende faktor (driver); (jf. afsnit 1)- at etik som primær driver vil betyde, at virksomheden vil gå ud over lovens minimumkrav, og stræbe efter de...

  15. A new corporate governance

    Directory of Open Access Journals (Sweden)

    Ion Bucur

    2015-12-01

    Full Text Available The issue of corporate governance has become increasingly important as globalisation has begun to accelerate and the economic and financial turmoil have intensified. Post-crisis context has imposed the need to expand the prospects for analysis over governance and companies, as well as the need to identify new ways of administration and resource management. From this perspective, the author aims to highlight the conditions, factors and events that have generated profound changes within the business environment, while the analysis is focusing on contemporary changes in the systems of corporate governance and economic mutations, especially in terms of the companies. The establishment of new governance rules is demanding a theoretical approach based on new methodological requirements which are needed to reform theoretical foundations and to promote creative and effective shapes and governance systems.

  16. Corporate creativity and innovation

    OpenAIRE

    Ericsson, Camilla; Dahlby, Tove

    2009-01-01

    This essay discusses organizational culture and focus on corporate creativity and innovation. The aim is to see which organizational factors that foster creativity and innovation in organizations. The essay will provide answer on how organizational culture can encourage creativity and innovation and how organizations can promote the rise of a creative work environment. The research design of this essay is a qualitative case study with interviews at Gotland Energi AB (GEAB). The interviews pro...

  17. Corporate Governance Communication

    OpenAIRE

    Gnecchi, Flavio

    2006-01-01

    The recognised critical importance of corporate governance, and the attention that it is paid today, can be ascribed to several factors: sensational financial scandals (and the repercussions they have had for securities and financial markets), the exponential development of stock option policies, the information asymmetry that can be noted in practically every company, The different requests for information of the various categories of stakeholders, combine to strengthen the decision to adopt...

  18. Corporate Social Responsibility

    OpenAIRE

    Priesterová, Lucia

    2008-01-01

    The main goal of this Diploma thesis is to find out, on the basis of research, how the companies from Czech and Slovak Republic perceive and apply in praxis the concept of corporate social responsibility. The work consists of theoretical and practical part. The theoretical part is included in the first three chapters. The first chapter defines the term CSR and illustrates the historical development of social responsibility. The second chapter presents various theories and approaches in the ar...

  19. Insights into the binding of Phenyltiocarbamide (PTC agonist to its target human TAS2R38 bitter receptor.

    Directory of Open Access Journals (Sweden)

    Xevi Biarnés

    Full Text Available Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs. Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38 by means of structural bioinformatics and molecular docking. The predictions are validated by site-directed mutagenesis experiments that involve specific residues located in the putative binding site and trans-membrane (TM helices 6 and 7 putatively involved in receptor activation. Based on our measurements, we suggest that (i residue N103 participates actively in PTC binding, in line with previous computational studies. (ii W99, M100 and S259 contribute to define the size and shape of the binding cavity. (iii W99 and M100, along with F255 and V296, play a key role for receptor activation, providing insights on bitter taste receptor activation not emerging from the previously reported computational models.

  20. Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor.

    Science.gov (United States)

    Biarnés, Xevi; Marchiori, Alessandro; Giorgetti, Alejandro; Lanzara, Carmela; Gasparini, Paolo; Carloni, Paolo; Born, Stephan; Brockhoff, Anne; Behrens, Maik; Meyerhof, Wolfgang

    2010-08-25

    Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38) by means of structural bioinformatics and molecular docking. The predictions are validated by site-directed mutagenesis experiments that involve specific residues located in the putative binding site and trans-membrane (TM) helices 6 and 7 putatively involved in receptor activation. Based on our measurements, we suggest that (i) residue N103 participates actively in PTC binding, in line with previous computational studies. (ii) W99, M100 and S259 contribute to define the size and shape of the binding cavity. (iii) W99 and M100, along with F255 and V296, play a key role for receptor activation, providing insights on bitter taste receptor activation not emerging from the previously reported computational models.

  1. Implementing a Corporate Weblog for SAP

    Science.gov (United States)

    Broß, Justus; Quasthoff, Matthias; MacNiven, Sean; Zimmermann, Jürgen; Meinel, Christoph

    After web 2.0 technologies experienced a phenomenal expansion and high acceptance among private users, considerations are now intensified to assess whether they can be equally applicable, beneficially employed and meaningfully implemented in an entrepreneurial context. The fast-paced rise of social software like weblogs or wikis and the resulting new form of communication via the Internet is however observed ambiguously in the corporate environment. This is why the particular choice of the platform or technology to be implemented in this field is strongly dependent on its future business case and field of deployment and should therefore be carefully considered beforehand, as this paper strongly suggests.

  2. Paradoxes in corporate theories of technological innovations

    DEFF Research Database (Denmark)

    Ulhøi, John Parm; Holm(ORG), Claus

    1996-01-01

    Artiklen har været præsenteret ved ovennævnte konference. Artiklen analyserer nogle tilsyneladende paradokser, der optræder inden for de virksomhedsrelaterede teorier om innovationsledelse. Løsningen heraf fremtræder som nogle af de centrale opgaver at få løst i den kommende tid. Der pointeres im...

  3. Oracle Corporation 1-2

    CERN Document Server

    CERN. Geneva

    2005-01-01

    During these sessions, Tom Kyte of Oracle Corporation will cover the following topics:# The Tools Tom uses, # The Top 5 things done wrong over and over again, # Building test cases, # Oracle 10g "cool features" Speaker Bio:Tom Kyte is the Vice President, Core Technologies for Oracle Government, Education and Healthcare. Before starting at Oracle, Tom Kyte worked as a systems integrator building large-scale, heterogeneous databases and applications, mostly for military and government customers. He spends a great deal of his time working with the Oracle database and, more specifically, working with people who are working with the Oracle database. Tom Kyte is the Tom behind the AskTom web site, answering people's questions about the Oracle database and its tools (http://asktom.oracle.com/). He is also the author of the AskTom column in http://www.oracle.com/technology/oramag/oracle/current.html Oracle Magazine, and the author of Expert One-on-One Oracle (Apress, 2003), Beginning Oracle Programming (Wrox Press, 2...

  4. Detection of PAX8/PPARG and RET/PTC Rearrangements Is Feasible in Routine Air-Dried Fine Needle Aspiration Smears

    DEFF Research Database (Denmark)

    Ferraz, Carolina; Rehfeld, Christian; Krogdahl, Annelise;

    2012-01-01

    Background: The diagnostic limitations of fine needle aspiration (FNA), like the indeterminate category, can be partially overcome by molecular analysis. As PAX8/PPARG and RET/PTC rearrangements have been detected in follicular thyroid carcinomas (FTCs) and papillary thyroid carcinomas (PTCs...... as generally not suitable for testing these rearrangements in a clinical setting. Therefore, the objective of the present study was to investigate the feasibility of extracting RNA from routine air-dried FNA smears for the detection of these rearrangements with real-time polymerase chain reaction (RT......-PCR). Methods: A new method for RNA extraction from routine air-dried FNA smears was established, which allowed analysis for the presence of four variants of PAX8/PPARG and RET/PTC 1 and RET/PTC 3, which were analyzed in 106 routine FNA smears and the corresponding surgically obtained FFPE tissues using real...

  5. EUV mask pilot line at Intel Corporation

    Science.gov (United States)

    Stivers, Alan R.; Yan, Pei-Yang; Zhang, Guojing; Liang, Ted; Shu, Emily Y.; Tejnil, Edita; Lieberman, Barry; Nagpal, Rajesh; Hsia, Kangmin; Penn, Michael; Lo, Fu-Chang

    2004-12-01

    The introduction of extreme ultraviolet (EUV) lithography into high volume manufacturing requires the development of a new mask technology. In support of this, Intel Corporation has established a pilot line devoted to encountering and eliminating barriers to manufacturability of EUV masks. It concentrates on EUV-specific process modules and makes use of the captive standard photomask fabrication capability of Intel Corporation. The goal of the pilot line is to accelerate EUV mask development to intersect the 32nm technology node. This requires EUV mask technology to be comparable to standard photomask technology by the beginning of the silicon wafer process development phase for that technology node. The pilot line embodies Intel's strategy to lead EUV mask development in the areas of the mask patterning process, mask fabrication tools, the starting material (blanks) and the understanding of process interdependencies. The patterning process includes all steps from blank defect inspection through final pattern inspection and repair. We have specified and ordered the EUV-specific tools and most will be installed in 2004. We have worked with International Sematech and others to provide for the next generation of EUV-specific mask tools. Our process of record is run repeatedly to ensure its robustness. This primes the supply chain and collects information needed for blank improvement.

  6. Essays on banking, corporate bankruptcy, and corporate finance

    OpenAIRE

    von Schedvin, E.L.

    2012-01-01

    This thesis consists of four chapters that empirical explore issues related to bank credit supply, corporate bankruptcy risk, and firms’ leverage decisions. The first chapter explores the role of contractual externalities in loan contracts. The second chapter evaluates the extent trade credit chains between corporate firms lead to propagation of corporate failures. The third chapter explores non-linear relationships between firm failure and leverage, earnings, and liquidity. The final chapter...

  7. Are Corporate Carbon Management Practices Reducing Corporate Carbon Emissions?

    OpenAIRE

    Doda, B; Gennaoli, C; Gouldson, A; Grover, D.; Sullivan, R.

    2016-01-01

    This paper is the first large scale, quantitative study of the impact of corporate carbon management practices on corporate greenhouse gas (GHG) emissions. Using data for 2009 and 2010 from the Carbon Disclosure Project survey, we find little compelling evidence that commonly adopted management practices are reducing emissions. This finding is unexpected and we propose three possible explanations for it. First, it may be because corporate carbon data and management practice information have n...

  8. Corporate Reputation and Corporate Social Responsibility : CSR for Higher Reputation

    OpenAIRE

    北見, 幸一

    2008-01-01

    There is an increased recognition of importance of corporate reputation and corporate social responsibility. The purpose of this paper is to consider the relationship between corporate reputation and CSR. In this study, the high reputation companies and the low reputation companies were picked up. According to this research, the high reputation companies sent more information about CSR to stake holders, and CSR communication was more positively done than the low reputation companies.

  9. 2015 Wind Technologies Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Electricity Markets and Policy Group; Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Electricity Markets and Policy Group; Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Darghouth, Naim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hoen, Ben [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mills, Andrew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rand, Joe [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Millstein, Dev [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Porter, Kevin [Exeter Associates, Columbia, MD (United States); Widiss, Rebecca [Exeter Associates, Columbia, MD (United States); Oteri, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tegen, Suzanne [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tian, Tian [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-08-03

    Annual wind power capacity additions in the United States surged in 2015 and are projected to continue at a rapid clip in the coming five years. Recent and projected near-term growth is supported by the industry’s primary federal incentive—the production tax credit (PTC)—having been extended for several years (though with a phase-down schedule, described further on pages 68-69), as well as a myriad of state-level policies. Wind additions are also being driven by improvements in the cost and performance of wind power technologies, yielding low power sales prices for utility, corporate, and other purchasers. At the same time, the prospects for growth beyond the current PTC cycle remain uncertain: growth could be blunted by declining federal tax support, expectations for low natural gas prices, and modest electricity demand growth. This annual report—now in its tenth year—provides a detailed overview of developments and trends in the U.S. wind power market, with a particular focus on 2015. The report begins with an overview of key installation-related trends: trends in U.S. wind power capacity growth; how that growth compares to other countries and generation sources; the amount and percentage of wind energy in individual states; the status of offshore wind power development; and the quantity of proposed wind power capacity in various interconnection queues in the United States. Next, the report covers an array of wind power industry trends: developments in turbine manufacturer market share; manufacturing and supply-chain developments; wind turbine and component imports into and exports from the United States; project financing developments; and trends among wind power project owners and power purchasers. The report then turns to a summary of wind turbine technology trends: turbine size, hub height, rotor diameter, specific power, and IEC Class. After that, the report discusses wind power performance, cost, and pricing trends. In so doing, it describes

  10. Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.

    Science.gov (United States)

    Rossi, Martina; Buratto, Mattia; Tagliati, Federico; Rossi, Roberta; Lupo, Sabrina; Trasforini, Giorgio; Lanza, Giovanni; Franceschetti, Paola; Bruni, Stefania; Degli Uberti, Ettore; Zatelli, Maria Chiara

    2015-02-01

    A molecular profile including BRAF and RAS mutations as well as RET/PTC rearrangement evaluation has been proposed to provide an accurate presurgical assessment of thyroid nodules and to reduce the number of unnecessary diagnostic surgeries, sparing patients' health and saving healthcare resources. However, the application of such molecular analyses may provide different results among different centers and populations in real-life settings. Our aims were to evaluate the diagnostic utility of assessing the presence of BRAF and RAS mutations and RET/PTC1 and RET/PTC3 rearrangements in all cytological categories in an Italian group of thyroid nodule patients assessed prospectively, and to understand whether and which mutation testing might be helpful in cytologically indeterminate nodules. A total of 911 patients were submitted to ultrasound and fine-needle aspiration biopsy examination. Cytological evaluation was performed in parallel with molecular testing and compared to pathological results in 940 thyroid nodules, including 140 indeterminate lesions. BRAF mutation testing provided the best contribution to cancer diagnosis, allowing the disease to be detected at an early stage, and identifying indeterminate nodules in which diagnostic lobectomy could be spared. On the contrary, RAS and RET/PTC analysis did not further increase diagnostic sensitivity for thyroid cancer. In addition, we found RET/PTC rearrangements in benign lesions, indicating that this molecular marker might not be useful for the detection of thyroid cancer. BRAF(V600E) mutation analysis is superior to RAS point mutations and evaluation of RET/PTC rearrangements in the diagnosis of thyroid cancer, even in indeterminate lesions.

  11. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from INCL patients

    Science.gov (United States)

    Sarkar, Chinmoy; Zhang, Zhongjian; Mukherjee, Anil B.

    2011-01-01

    Infantile neuronal ceroid lipofuscinosis (INCL), a lethal hereditary neurodegenerative lysosomal storage disorder, affects mostly children. It is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. Nonsense mutations in a gene generate premature termination codons producing truncated, nonfunctional or deleterious proteins. PPT1 nonsense-mutations account for approximately 31% of INCL patients in the US. Currently, there is no effective treatment for this disease. While aminoglycosides such as gentamycin suppress nonsense mutations, inherent toxicity of aminoglycosides prohibits chronic use in patients. PTC124 is a non-toxic compound that induces ribosomal read-through of premature termination codons. We sought to determine whether PTC124-treatment of cultured cells from INCL patients carrying nonsense mutations in the PPT1 gene would correct PPT1 enzyme-deficiency with beneficial effects. Our results showed that PTC124-treatment of cultured cells from INCL patients carrying PPT1 nonsense-mutations induced PPT1 enzymatic activity in a dose- and time-dependent manner. This low level of PPT1 enzyme activity induced by PTC124 is virtually identical to that induced by gentamycin-treatment. Even though only a modest increase in PPT1 activity was achieved by PTC124-treatment of INCL cells, this treatment reduced the levels of thioester (constituent of ceroid) load. Our results suggest that PTC124-treatment induces PPT1 enzymatic activity in cultured cells from INCL patients carrying PPT1 nonsense-mutations, and this modest enzymatic activity has demonstrable beneficial effects on these cells. The clinical relevance of these effects may be tested in animal models of INCL carrying nonsense mutations in the PPT1 gene. PMID:21704547

  12. Differential expression profiling of circulation microRNAs in PTC patients with non-131I and 131I-avid lungs metastases: a pilot study.

    Science.gov (United States)

    Qiu, Zhong-Ling; Shen, Chen-Tian; Song, Hong-Jun; Wei, Wei-Jun; Luo, Quan-Yong

    2015-05-01

    Loss of the ability to concentrate (131)I is one of the important causes of radioiodine-refractory disease in papillary thyroid carcinoma (PTC). Recent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of many cancers. The aim of the current study was to identify differential expression profiling of circulation miRNAs in PTC patients with non-(131)I and (131)I-avid lungs metastases. The expressions of miRNAs were examined using miRNA microarray chip. The most significantly changed miRNAs from microarray were verified by using qRT-PCR. The potential miRNAs regulating target genes and their preliminary biological functions were forecasted by Bioinformatic analysis. Compared to (131)I-avid lung metastases, 13 kinds of significantly differential serum miRNAs including 5 upregulated miRNAs (miR-1249, miR-106a, miR-503, miR-34c-5p, miR-1281) and 8 downregulated miRNAs (miR-1915, miR-2861, miR-3196, miR-500, miR-572, miR-33b, miR-554, miR-18a) in PTC patients with non-(131) I-avid lung metastases were identified. Bioinformatic analysis demonstrated that miR-106a was the core miRNA regulating 193 genes in the network. The results of validation confirmed the up-regulation of miR-106a in non-(131)I-avid lungs metastatic PTC patients. Differentially expressed serum miRNA profiles between PTC patients with non-(131)I and (131)I-avid lungs metastases were analyzed. These findings in our present study could represent new clues for the diagnostic and therapeutic strategy in PTC patients with non-(131)I-avid metastatic disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Code of Sustainable Practice in Occupational and Environmental Health and Safety for Corporations.

    Science.gov (United States)

    Castleman, Barry; Allen, Barbara; Barca, Stefania; Bohme, Susanna Rankin; Henry, Emmanuel; Kaur, Amarjit; Massard-Guilbaud, Genvieve; Melling, Joseph; Menendez-Navarro, Alfredo; Renfrew, Daniel; Santiago, Myrna; Sellers, Christopher; Tweedale, Geoffrey; Zalik, Anna; Zavestoski, Stephen

    2008-01-01

    At a conference held at Stony Brook University in December 2007, "Dangerous Trade: Histories of Industrial Hazard across a Globalizing World," participants endorsed a Code of Sustainable Practice in Occupational and Environmental Health and Safety for Corporations. The Code outlines practices that would ensure corporations enact the highest health and environmentally protective measures in all the locations in which they operate. Corporations should observe international guidelines on occupational exposure to air contaminants, plant safety, air and water pollutant releases, hazardous waste disposal practices, remediation of polluted sites, public disclosure of toxic releases, product hazard labeling, sale of products for specific uses, storage and transport of toxic intermediates and products, corporate safety and health auditing, and corporate environmental auditing. Protective measures in all locations should be consonant with the most protective measures applied anywhere in the world, and should apply to the corporations' subsidiaries, contractors, suppliers, distributors, and licensees of technology. Key words: corporations, sustainability, environmental protection, occupational health, code of practice.

  14. The Dynamics of Corporate Brand Charisma

    DEFF Research Database (Denmark)

    Hatch, Mary Jo; Schultz, Majken

    2013-01-01

    's theory of the routinization of charisma. The study took place in the relatively unusual context of a truncated rollout of a formal corporate branding program, which allowed us to study the processes by which brand charisma was routinized. Findings indicate the important intermediary role played by middle......This article describes how Carlsberg Group's IT unit (CIT) made use of Carlsberg's corporate brand to develop its identity following centralization and downsizing of the IT function. Our observations suggested using the concept of brand charisma and thereafter we framed our analysis with Weber...... managers who selected and systematized the set of brand beliefs taken up within the CIT project, and how employees accommodated these beliefs to their everyday work life. Accommodation was found to take place within four subdomains of activity: subculture, communication, technology, and hierarchical...

  15. Retro-Innovation and Corporate Social Responsibility

    Directory of Open Access Journals (Sweden)

    Loucanova Erika

    2015-11-01

    Full Text Available The paper deals with the retro-innovation and their importance to corporate social responsibility (CSR. Corporate social responsibility is a process with the aim to encourage a positive impact through activities on the environment, consumers, employees, communities, and all other stakeholders of the public sphere. The accelerated rate of technological and social change influences on the society. The main social problems are symptoms of future shock. Retro-innovation trend is emerging against an accelerating backdrop of “datafication”. New products are designed to connect customers with the past in ways that are nostalgic, interactive and environmental. CSR thanks to the retroinnovation encourages has a positive impact on the all stakeholders and eliminates the future shock.

  16. Water Stewardship and Corporate Sustainability

    OpenAIRE

    Jones, Peter; Comfort, Daphne; David HILLIER

    2014-01-01

    The aim of this paper is to provide an exploratory review of the extent to which some of the world’s leading companies are publicly addressing water stewardship as part of their corporate sustainability strategies. The paper begins with an outline of the growing importance of corporate sustainability and water stewardship. The paper draws its empirical material from the most recent information on sustainability posted on the top twelve ‘Consumer Superbrands’ corporate websites. The findings r...

  17. Measuring instruments of corporate reputation

    OpenAIRE

    Damir Grgić

    2008-01-01

    The subject of this paper is focused on the instruments for the measurement of corporate reputation. Recent research of the elements which influence the success of a company shows a growing interest in intangible values. Corporate reputation itself has been identified as one of the key intangible assets which create the company’s added value. Understanding of the importance of corporate reputation has been determined as a significant component of the company’s competitiveness, that is, of its...

  18. The Institutions of Corporate Governance

    OpenAIRE

    Roe, Mark J.

    2004-01-01

    In this review piece, I outline the institutions of corporate governance decision-making in the large public firm in the wealthy West. By corporate governance, I mean the relationships at the top of the firm - the board of directors, the senior managers, and the stockholders. By institutions I mean those repeated mechanisms that allocate authority among the three and that affect, modulate, and control the decisions made at the top of the firm. Core corporate governance institutions respon...

  19. THE SOUND OF CORPORATE GOVERNANCE

    Directory of Open Access Journals (Sweden)

    DUMITRASCU LUMINITA MIHAELA

    2012-07-01

    Full Text Available The paper explores the corporate governance and corporate social responsibility in music industry, by reviewing the literature and investigating the aspects in the context of a sample made by top companies in this domain. The paper spotlighting the mutual connections between corporate governance and corporate social responsibility. The research methodology used consists in investigate the corporate governance codes. It’s about a qualitative interpretive research methodology that was adopted. The findings suggest the intercorelation of corporate governance with corporate social responsibility. The main contribution of the author consists in the fact that the added value of this paper and the original contribution leads in the intercorelation of these two aspects of corporate governance and corporate social responsibility, the findings beeing interesting, implying that recent preoccupation with corporate governance in music industry is starting to be equable by some attention to social responsibility aspects, with growing appreciation of their interdependencies. Previous literature has researched corporate governance and corporate social responsibility independently. Due to this fact, this paper is considering them jointly. The paper is important for both practical and theoretical aspects: for managers and also can serve as the basis for future research on this topic. The current paper is realized in the doctoral program entitled “PhD in Economics at the Standards of European Knowledge- DoEsEc”, scientific coordinator Prof. PhD Niculae Feleaga, Institution: The Academy of Economic Studies Bucharest, Faculty of Accounting and Management Informatic System, Department of International Accounting, period of research 2009-2012.

  20. Strategic Leadership of Corporate Sustainability

    DEFF Research Database (Denmark)

    Strand, Robert

    2014-01-01

    ? What effects do corporate sustainability TMT positions have at their organizations? We consider these questions through strategic leadership and neoinstitutional theoretical frameworks. Through the latter, we also engage with Weberian considerations of bureaucracy. We find that the reasons why......Strategic leadership and corporate sustainability have recently come together in conspicuously explicit fashion through the emergence of top management team (TMT) positions with dedicated corporate sustainability responsibilities. These TMT positions, commonly referred to as 'Chief Sustainability...

  1. Trends in Corporate Communication Strategies

    OpenAIRE

    Constantin Milosteanu; Ionel Scaunasu; Alina Cornescu; Nicolae Popovic

    2011-01-01

    When business strategy is correlated with corporate communication strategy, this is reflected in the position and image of the organization on the market, leading to higher sales and increased profitability. The major changes caused by globalization, coupled with the new dynamic of the markets where consumers have access to more information in less time, require new forms of corporate communication. The new corporate communication concept involves major challenges for managers and can help de...

  2. Trends in Corporate Communication Strategies

    OpenAIRE

    Constantin Milosteanu; Ionel Scaunasu; Alina Cornescu; Nicolae Popovic

    2011-01-01

    When business strategy is correlated with corporate communication strategy, this is reflected in the position and image of the organization on the market, leading to higher sales and increased profitability. The major changes caused by globalization, coupled with the new dynamic of the markets where consumers have access to more information in less time, require new forms of corporate communication. The new corporate communication concept involves major challenges for managers and can help de...

  3. Corporate social responsibility in Ukraine

    OpenAIRE

    Polyakova, E.

    2013-01-01

    In the article are considered essence of corporate social responsibility and terms necessary for realization of social activity management subjects. Hikes over are brought to realization of corporate social responsibility, meaningfulness of large and middle business is certain in becoming of social responsibility of enterprises. It is set that exactly midsize business must come forward as a main motor of economic development of Ukraine. Becoming features and modern state of corporate social r...

  4. State ownership and corporate governance

    OpenAIRE

    Pargendler, Mariana

    2012-01-01

    State ownership of publicly-traded corporations remains pervasive around the world, and has been increasing in recent years. Existing literature focuses on the implications of government ownership for corporate governance and performance at the firm level. This Article, by contrast, explores the different but equally important question of whether the presence of the state as a shareholder can impose negative externalities on the corporate law regime available to the private sec...

  5. CORPORATE GOVERNANCE TERHADAP KINERJA PERUSAHAAN

    OpenAIRE

    Herman Darwis

    2017-01-01

    The research aimed to provide empirical evidence that corporate governance implementation,managerial ownership, institutional ownership, board of executive, and independent executiveaffected corporate performance. Population of the research was companies listed at IndonesianStock Exchange (ISX) between 2006 – 2008; sampling method used was purposive sampling as well asmultiple regression analysis. The result showed the implementation of GCG affected corporate performance.This meant that if th...

  6. Corporate Governance Disclosure in Malaysia

    OpenAIRE

    ONG, Wei Jiin

    2006-01-01

    This research provides evidence on corporate governance disclosure in Malaysia based on a sample of 25 Malaysian public listed companies on the Kuala Lumpur Composite Index (KLCI) in the year 1998 and 2005 that are listed on the Bursa Malaysia. The purpose of this dissertation is to examine whether after the launch of the Malaysian Code on Corporate Governance (HLFC, 2000) following the 1997/98 financial crisis, corporate governance in Malaysia has improved in terms of disclosure information ...

  7. Inter-Corporeity

    Directory of Open Access Journals (Sweden)

    Algis Mickūnas

    2011-02-01

    Full Text Available The essay explicates the phenomenological problematic of intersubjectivity on the level of bodily interaction with the world and with others. On this level, the concept of visibility is transformed in terms of the primacy of bodily “I can” and the kinaesthetic awareness that pervades all perceptual fields. In addition, the investigations into kinaesthetic awareness lead to the understanding that one’s own bodily action is extended as well as varied by the kinaesthetic activities of others and thus form an inter-corporeal field wherein visibility is located. Such an extended awareness is the bodily counterpart of transcendental domain. 

  8. To Change Corporate Culture

    Institute of Scientific and Technical Information of China (English)

    尹雁

    2007-01-01

    1. Analysis of Culture and Managing change 1.1 The Two Varies of Models 1.1.1 Five-step model According to ’five-step model’, the progress of change could be divided into five stages. Firstly, manager needs to think why a culture change is necessary. Possibly due to the signals from the environment in which the company locate in, managers find the operating principles or routines are not in line with the change of the market. These elements have threatened the corporation. On this occasion, managers could start to analyze what kind of culture the organization possesses.

  9. Peculiarities of Corporate Governance Methodology

    Directory of Open Access Journals (Sweden)

    Victoria Vladimirovna Prokhorova

    2016-04-01

    Full Text Available This work is devoted to the study of the quality and identification of priorities of institutional investors in corporate governance in Russia. The authors conclude that the main task of the corporate governance system is to create favorable conditions for broad attraction of foreign investments in Russian companies and to increase the role of shareholders in strategic management. At present, the companies from developed countries achieve higher economic performance through the introduction of modern methods of corporate governance. The adoption of the new Code of Corporate Governance in the Russian Federation in 2014 will create an opportunity to improve the efficiency of Russian companies and to conduct their activities in accordance with international standards through the introduction of modern corporate governance practices, including ensuring transparency of activities for investors. At the same time, despite significant improvements in corporate governance practices of Russian companies, the level of its quality in comparison with foreign countries remains low. The article highlights both positive and negative trends in the Russian practice of corporate governance. One of the effective corporate governance methods is to ensure feedback between Russian companies and institutional investors. The article presents the results of a survey of opinions of investors that allow to identify the main factors of corporate governance that motivate them to take investment decisions on the Russian market.

  10. Corporate Accounting Policy Efficiency Improvement

    Directory of Open Access Journals (Sweden)

    Elena K. Vorobei

    2013-01-01

    Full Text Available The article is focused on the issues of efficient use of different methods of tax accounting for the optimization of income tax expenses and their consolidation in corporate accounting policy. The article makes reasoned conclusions, concerning optimal selection of depreciation methods for tax and bookkeeping accounting and their consolidation in corporate accounting policy and consolidation of optimal methods of cost recovery in production, considering business environment. The impact of the selected methods on corporate income tax rates and corporate property tax rates was traced and tax recovery was estimated.

  11. Peculiarities of Corporate Governance Methodology

    National Research Council Canada - National Science Library

    Victoria Vladimirovna Prokhorova

    2016-01-01

    ... of shareholders in strategic management. At present, the companies from developed countries achieve higher economic performance through the introduction of modern methods of corporate governance...

  12. Creditor Governance and Corporate Policies

    DEFF Research Database (Denmark)

    Arnold, Marc; Westermann, Ramona

    This paper analyzes the impact of debt covenant renegotiations on corporate policies. We develop a structural model of a levered firm that can renegotiate debt both at investment and in corporate distress. Covenant renegotiation at investment disciplines equity holders in their financing...... and investment decisions and, hence, mitigates the agency cost of debt. Our model explains the empirical intensity and patterns of the occurrence of debt renegotiation. We also quantify the role of debt covenant renegotiations as a governance channel on corporate financial policies and on the value of corporate...

  13. On the teaching of the relationship between genes and taste-blindness of phenylthiocarbamide(PTC)%对"基因和苯硫脲(PTC)味盲的关系"的教学探讨

    Institute of Scientific and Technical Information of China (English)

    王苏豫

    2010-01-01

    以"基因和苯硫脲(PTC)味盲的关系"的教学为例,对研究性学习的教学内容和方法进行了初步探讨.针对基因和苯硫脲味盲的关系的研究,从问题的提出、假设的形成和实验所涉及的实验试剂的配制、试剂浓度、尝味方法多方面引导学生进行讨论,力图通过生物学教学中真实的科学研究过程,提高学生的生物科学素养.

  14. Visual analysis and exploration of complex corporate shareholder networks

    Science.gov (United States)

    Tekušová, Tatiana; Kohlhammer, Jörn

    2008-01-01

    The analysis of large corporate shareholder network structures is an important task in corporate governance, in financing, and in financial investment domains. In a modern economy, large structures of cross-corporation, cross-border shareholder relationships exist, forming complex networks. These networks are often difficult to analyze with traditional approaches. An efficient visualization of the networks helps to reveal the interdependent shareholding formations and the controlling patterns. In this paper, we propose an effective visualization tool that supports the financial analyst in understanding complex shareholding networks. We develop an interactive visual analysis system by combining state-of-the-art visualization technologies with economic analysis methods. Our system is capable to reveal patterns in large corporate shareholder networks, allows the visual identification of the ultimate shareholders, and supports the visual analysis of integrated cash flow and control rights. We apply our system on an extensive real-world database of shareholder relationships, showing its usefulness for effective visual analysis.

  15. The effects of BRAF gene mutation on PTC lymph node metastasis in central region%BRAF基因突变对甲状腺乳头状癌(PTC)中央区淋巴结转移的影响

    Institute of Scientific and Technical Information of China (English)

    于景超; 秦华东; 石铁锋; 石臣磊

    2015-01-01

    目的:探讨BRAF基因突变对甲状腺乳头状癌(PTC)中央区淋巴结转移的相关性因素,着重研究BRAF基因突变中不同肿瘤直径对PTC的影响.方法:回顾性分析本院甲状腺外科2011年10月-2013年10月2年间手术切除的136例PTC病例,分析BRAF基因突变与相关因素之间的关系.结果:PTC中BRAF基因突变率为69.85% (95/136).BRAF基因突变阳性者颈部中央区淋巴结转移率为34.74%(33/95),BRAF基因突变阴性者中央区淋巴结转移率为12.2% (5/41),两者统计学差异具有相关性(p<0.05).肿瘤直径大于2cm时BRAF基因突变率为90.48%(19/21),直径小于等于2cm时BRAF基因突变率为66.09%(76/115),两者统计学差异具有相关性(P<0.05).结论:BRAF基因突变与PTC中央区淋巴结转移存在相关性.对于术前检测BRAF突变阳性的病例,当肿瘤直径大于2cm时应该常规清扫该中央区淋巴脂肪组织.

  16. KETERKAITAN WHITE COLLAR CRIME DENGAN CORPORATE CRIME

    OpenAIRE

    R. Dyatmiko Soemodihardjo

    2003-01-01

    White collar crime is a crime that carried out by respected persons, whereas corporate crime is a crime that related to corporation. White collar crime and crime corporate are always related to economic crime. White collar crime can be committed by corporation, that is why a kind of crime emerges namely corporate crime.

  17. Rise of a New Corporate Vehicle

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2014-01-01

    So-called Public Benefit Corporations do not bring any revolutionary amendments to the way the traditional corporations are. But they represent a shift in the way our corporate mind and mentality is evolving. Despite the deficiencies in legislation, it must be acknowledged that this new corporate...... vehicle indicates that for some corporations public benefit objectives become more important than profits....

  18. Corporate citizenship: Statoil.

    Science.gov (United States)

    Fjell, Olav

    2003-01-01

    Open markets alone do not guarantee equitable and sustainable development. Income disparities are growing both within and between countries to the extent that the marginalization of the poor has become a key challenge of globalization. To meet this challenge, the global community must address the governance gap between global finance/economics and local or national politics in world affairs. This article discusses how globalization is shaping Statoil's approach to corporate citizenship. The Norwegian firm, with 17,000 workers in some 25 countries, is one of the major net sellers of crude oil and supplies Europe with natural gas. Statoil maintains that corporations can contribute to global governance by conducting business in a manner that is ethical, economically viable, environmentally sound, and socially responsible. This contribution can be achieved through development partnerships with national governments, multilateral institutions, and nongovernmental organizations. Norway's Statoil ASA is one of the world's largest net sellers of crude oil and a major supplier of natural gas to Europe. It is the leading Scandinavian retailer of petroleum and other oil products. Statoil employs approximately 17,000 workers and operates in 25 countries.

  19. Business Development Corporation, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Jasek, S.

    1995-12-31

    Business Development Corporation, Inc., is a company specializing in opportunity seeking and business development activities in the {open_quotes}new{close_quotes} post communist Central and Eastern Europe, with particular emphasis on the Republics of Poland and Slovakia. The company currently focuses its expertise on strategic investing and business development between Central Europe and the United States of America. In Poland and Slovakia, the company specializes in developing large scale energy and environmental {open_quotes}infrastructure{close_quotes} development projects on the federal, state, and local level. In addition, the company assists large state owned industries in the transformation and privatization process. Business Development Corporation has assisted and continues to assist in projects of national importance. The staff of experts advise numerous large Polish and Slovak companies, most owned or in the process of privatization, on matters of restructuring, finance, capital structure, strategic parternships or investors, mergers, acquisitions and joint ventures with U.S. based firms. The company also assists and advises on a variety of environmental and energy matters in the public and private sector.

  20. Multilevel corporate environmental responsibility.

    Science.gov (United States)

    Karassin, Orr; Bar-Haim, Aviad

    2016-12-01

    The multilevel empirical study of the antecedents of corporate social responsibility (CSR) has been identified as "the first knowledge gap" in CSR research. Based on an extensive literature review, the present study outlines a conceptual multilevel model of CSR, then designs and empirically validates an operational multilevel model of the principal driving factors affecting corporate environmental responsibility (CER), as a measure of CSR. Both conceptual and operational models incorporate three levels of analysis: institutional, organizational, and individual. The multilevel nature of the design allows for the assessment of the relative importance of the levels and of their components in the achievement of CER. Unweighted least squares (ULS) regression analysis reveals that the institutional-level variables have medium relationships with CER, some variables having a negative effect. The organizational level is revealed as having strong and positive significant relationships with CER, with organizational culture and managers' attitudes and behaviors as significant driving forces. The study demonstrates the importance of multilevel analysis in improving the understanding of CSR drivers, relative to single level models, even if the significance of specific drivers and levels may vary by context.

  1. How Corporate Governance Affects Strategy of Corporations : - Lessons from Enron Corporation -

    OpenAIRE

    Ahmed, Hameed; Najam, Ali

    2006-01-01

    Corporate governance is a subject of academic and professional debate. It has and it will continue to be a topic under scrutiny for subsequent deliberations since there are many different research dimensions and contexts associated with it. However, it has been observed that the linkage between corporate governance and strategy of a corporation remains as an untapped area with considerable avenues of research. This paper tends to explore this linkage, using Enron scandal as backdrop. In the a...

  2. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER PALL CORPORATION WPM-1 MICROFILTRATION SYSTEM AT PITTSBURGH, PA - NSF 00/09/EPADW395

    Science.gov (United States)

    Verification testing of the Pall Corporation WPM-1 Microfiltration Pilot System was conducted from February 3 to March 5, 1999. The Pall WPM-1 membrane is a hollow fiber type microfiltration membrane made of polyvinylidenefluoride (PVDF). It has a 0.1 micrometer ( m) nominal por...

  3. PengaruhCorporate GovernanceTerhadap Hubungan Corporate Social ResponsibilityDan Nilai Perusahaan

    OpenAIRE

    2012-01-01

    2012 PengaruhCorporate GovernanceTerhadap Hubungan Corporate Social ResponsibilityDan Nilai Perusahaan Effect of Corporate Governance onthe Relationship of Corporate Social Responsibility and Firm Value Herlina Samsi Mushar Mustafa Grace T. Pontoh Penelitian ini bertujuan untuk mengetahui pengaruh corporate governance terhadap hubungan corporate social responsibility dan nilai perusahaan. Data penelitian ini diperoleh dari laporan keberlanjutan, lapor...

  4. Corporate Social Responsibility for Sustainability

    Directory of Open Access Journals (Sweden)

    Wojciech Przychodzeń

    2014-06-01

    Full Text Available Purpose: The purpose of this paper is to is to provide insights on implementing corporate social responsibility for sustainability (CSRS concept and show how it differs from basic corporate social responsibility (CSR. Methodology: The paper discusses major issues with references to existing literature and real business cases from S&P500 consumer discretionary sector. Findings: The main fi nding of this paper is that CSRS could provide the company with a competitive advantage as a growing number of consumers become more sustainable conscious. It could also help to overcome the increasing consumers’ skepticism towards corporate social responsibility practices. Finally, it can also be seen as a step forward in defi ning what types of corporate activities are associated with desirable social and environmental gains. Research limitations: Our sample was restricted to the U.S. fi rms from the consumer discretionary sector. Therefore, conclusions should not be generalized to other markets. Our study is based on the analysis of environmental and social responsibility statements and assumes that they accurately represent corporate commitment in majority of the cases. Practical implications: CSRS offers corporations the opportunity to use their unique skills, culture, values, resources, and management capabilities to lead social progress by making sustainability part of its internal corporate logic. Originality: The paper raises the importance of the different conditions necessary for making sustainable development concept an important part of corporate strategy.

  5. Corporate Governance, CSR og menneskerettigheder

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2005-01-01

    Artiklen diskuterer om der findes en forbindelse mellem Corporate Governance og Corporate Social Responsibility i forhold til menneskerettigheder. Det konkluderes, at en sådan forbindelse findes, i hvert fald i forhold til arbejdstagerrettigheder og dele af forholdet til eksterne stakeholdere. Me...

  6. Corporate Architecture and Limited Liability

    NARCIS (Netherlands)

    Couwenberg, Oscar

    2007-01-01

    Abstract This paper studies the effect of limited liability on corporate architecture. Corporate architecture refers to the use of governance instruments within the firm to control the behavior of employees. Four general instruments are defined that form the basis of the firm as a governance arrange

  7. Internal communication in corporate groups

    OpenAIRE

    Grzesik, Katarzyna

    2015-01-01

    This chapter is dedicated to internal communication in corporate groups. It discusses internal communication systems operating in the explored corporate groups and their significance for effective human resources management in those organisations. The chapter presents both the theoretical analysis based on the results of literature studies, and empirical research carried out in the explored groups. Narodowe Centrum Nauki Katarzyna Grzesik

  8. The Banning of Corporal Punishment.

    Science.gov (United States)

    Cryan, John R.

    1995-01-01

    Presents the 1985 resolution of the Association for Childhood Education International (ACEI) for participation in the interdisciplinary effort to ban corporal punishment. Discusses distinctions between discipline and child abuse. Reports medical and psychological effects of physical punishment, and relationships between school corporal punishment…

  9. Corporal Punishment and Child Adjustment

    Science.gov (United States)

    Aucoin, Katherine J.; Frick, Paul J.; Bodin, S. Doug

    2006-01-01

    The association between corporal punishment and children's emotional and behavioral functioning was studied in a sample of 98 non-referred children with a mean age of 12.35 (SD=1.72) recruited from two school systems in the southeastern United States. Children were divided into those who had experienced no corporal punishment over approximately a…

  10. Sinopec International Petroleum Service Corporation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Established in December 2003, Sinopec international Petroleum Service Corporation (SIPSC) is a fullyowned subsidiary of China Petrochemical Corporation (Sinopec Group). The company is mainly engaged in contracting international petroleum service projects and providing technical services, and is responsible for uniform management, coordination and organization of contracted international projects and labor service cooperation performed by Sinopec's upstream subsidiaries.

  11. A Profile of Corporate Contributions.

    Science.gov (United States)

    Smith, Hayden W.

    The extent and distribution of charitable contributions by corporations were studied. In addition to a history of giving from 1936 to 1981, information is presented on corporate contributions in 1977 in terms of the distribution of companies (1) by size of contributions, (2) by contributions as percentage of net income, (3) by industry, and (4) by…

  12. Constructing corporate identities on websites

    DEFF Research Database (Denmark)

    Bøilerehauge, Dorrit

    2007-01-01

    En analyse og diskussion af hvorledes internationale virksomheder konstruerer deres identitet på deres corporate websites.......En analyse og diskussion af hvorledes internationale virksomheder konstruerer deres identitet på deres corporate websites....

  13. Studies on Dutch Housing Corporations

    NARCIS (Netherlands)

    Veenstra, Jacob

    2016-01-01

    One third of all dwellings in the Netherlands is owned by housing corporations. These are privately governed institutions executing a public task (social housing). Recently, corporations have received negative attention due to various incidents (such as fraud and excessive risk-taking). This put pre

  14. A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation

    Science.gov (United States)

    Goldmann, Tobias; Overlack, Nora; Möller, Fabian; Belakhov, Valery; van Wyk, Michiel; Baasov, Timor; Wolfrum, Uwe; Nagel-Wolfrum, Kerstin

    2012-01-01

    Translational read-through-inducing drugs (TRIDs) promote read-through of nonsense mutations, placing them in the spotlight of current gene-based therapeutic research. Here, we compare for the first time the relative efficacies of new-generation aminoglycosides NB30, NB54 and the chemical compound PTC124 on retinal toxicity and read-through efficacy of a nonsense mutation in the USH1C gene, which encodes the scaffold protein harmonin. This mutation causes the human Usher syndrome, the most common form of inherited deaf-blindness. We quantify read-through efficacy of the TRIDs in cell culture and show the restoration of harmonin function. We do not observe significant differences in the read-through efficacy of the TRIDs in retinal cultures; however, we show an excellent biocompatibility in retinal cultures with read-through versus toxicity evidently superior for NB54 and PTC124. In addition, in vivo administration of NB54 and PTC124 induced recovery of the full-length harmonin a1 with the same efficacy. The high biocompatibilities combined with the sustained read-through efficacies of these drugs emphasize the potential of NB54 and PTC124 in treating nonsense mutation-based retinal disorders. PMID:23027640

  15. 78 FR 66318 - Securities Investor Protection Corporation

    Science.gov (United States)

    2013-11-05

    ... COMMISSION 17 CFR Part 300 Securities Investor Protection Corporation AGENCY: Securities and Exchange Commission. ACTION: Proposed rule. SUMMARY: The Securities Investor Protection Corporation (``SIPC'') filed a..., the Options Clearing Corporation (``OCC'') proposed, and the Commission approved, a rule change...

  16. Corporate Support of Education: Some Strings Attached

    Science.gov (United States)

    Malott, Robert H.

    1978-01-01

    Corporate self-interest should guide corporate giving. Managers of publicly held corporations have the right, the capability, and the obligation to establish a philosophical screen to use in determining how shareholders' money is to be donated. (Author/MLF)

  17. Corporate Support of Education: Some Strings Attached

    Science.gov (United States)

    Malott, Robert H.

    1978-01-01

    Corporate self-interest should guide corporate giving. Managers of publicly held corporations have the right, the capability, and the obligation to establish a philosophical screen to use in determining how shareholders' money is to be donated. (Author/MLF)

  18. Corporate Foresight and Strategic Decisions

    DEFF Research Database (Denmark)

    Gomez Portaleoni, Claudio; Marinova, Svetla Trifonova; Ul-Haq, Rehan

    The investigation of the future of an organization has always captivated the attention of academics and business managers. Presently, the aspiration to entrench future-relevant insights into management practices is a must. Companies that have made attempts to use corporate foresight have generally...... dealt successfully with internal information sharing processes that in most cases have prepared them for the challenges of the future. Corporate Foresights and Strategic Decisions investigates the relationships between corporate foresight and management decision-making processes in organizations....... It provides an extensive analysis of extant theories of corporate foresight and strategic management, brings in new notions and insights, and presents an in-depth case study exploration of corporate foresight of a European bank. The understanding of organizational future is influenced by the perceived...

  19. The State of the Corporation

    DEFF Research Database (Denmark)

    Hein Jessen, Mathias

    and the corporation, seeing that the state is itself a corporate entity, albeit one which has achieved a privileged position in our political understanding as the repository of sovereignty and the sole legitimate claimant to political authority and allegiance. The state has throughout history governed social life......Today it has become commonplace to claim the demise of the power of the democratic nation-state due to globalization, neoliberal policies and the increasing power of transnational entities (UN, EU, IMF, WTO, World Bank) and multinational corporations. This view, however, prevalent in both public...... discourse and political debates, rests on a misguided conception of the state and on a sharp demarcation between the state and the corporation. This demarcation – between state and corporation and the political and the economic – is fundamental to the functioning of state power and to the existing political...

  20. Conservatism in Corporate Valuation

    DEFF Research Database (Denmark)

    Bach, Christian

    overestimate the cost of risk. This "error" more than offsets yet another "error", committed when using analyst's forecasts of long-term growth which are 3-4 times higher than what can be considered reasonable. Using the CCAPM approach to valuation, the results imply that investors are very conservative...... in their valuation of long-term value generation and very conservative in risk adjusting future value generation.......Using a CCAPM based risk adjustment model, consistent with general asset pricing theory, I perform corporate valuations of a large sample of stocks listed on NYSE, AMEX and NASDAQ. The model is different from the standard CAPM model in the sense that it discounts forecasted residual income for risk...