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Sample records for technology assessment ota

  1. Assessing Measurement Distances for OTA Testing of Massive MIMO Base Station at 28 GHz

    DEFF Research Database (Denmark)

    Kyösti, Pekka; Fan, Wei; Kyrolainen, Jukka

    2017-01-01

    This paper discusses physical dimensions for a multi probe anechoic chamber based (MPAC) over-the-air (OTA) setup aiming for base station (BS) testing. The target frequency of the simulated massive multiple-input-multiple-output (MIMO) BS arrays is 28 GHz. The assessment is performed with two...... metrics. The first metric is a new power metric based on assumptions of a code book of fixed beams and planar waves. The second one is the multi-user (MU) MIMO sum rate capacity. The intention is to evaluate physical dimensions in metres with respect to different BS array sizes. Simulation results...... indicate that OTA performance of a BS array with maximum dimension of 0.15m could be measured with a setup having measurement distance of approximately 1m...

  2. Melanin index in assessing the treatment efficacy of 1064 nm Q switched Nd-Yag laser in nevus of Ota

    Directory of Open Access Journals (Sweden)

    Gomathy Sethuraman

    2013-01-01

    Full Text Available Background: Q-switched neodymium-yttrium aluminium-garnet (Q switched Nd-Yag laser has been used in the treatment of nevus of Ota in all skin types with variable success rate. Data with an objective assessment parameter to this laser treatment is lacking. Objective: To evaluate the utility of melanin index in assessing the treatment response and also determine the efficacy and safety of the Q-switched Nd-Yag laser (1064-nm in the treatment of nevus of Ota in Fitzpatrick skin types IV and V. Materials and Methods: A total of 35 patients treated with Nd-Yag laser were studied. The objective improvement (pigment clearance was determined by melanin index from two fixed points: A1, 2 cm below the pupil at the mid pupillary line (when the gaze is fixed; A2, the most prominent part of zygoma. The melanin index in these two areas was recorded as M1 and M2, respectively. The subjective clinical improvement was determined by the physician and the patient global assessment score. Results: The mean baseline melanin indices M1 and M2 were 59.54 ± 9.72 and 59.02 ± 9.16, respectively. At the last visit the mean M1 and M2 decreased to 53.8 ± 8.55 (P 50% pigment clearance. Conclusion: The melanin index, a simple non-invasive parameter is useful in assessing the treatment response more objectively. The 1064-nm Q-switched Nd-Yag laser offers good improvement in patients with nevus of Ota in darker skin types IV/V.

  3. Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota

    Science.gov (United States)

    Sethuraman, Gomathy; Sharma, Vinod K; Sreenivas, Vishnubhatla

    2013-01-01

    Background: Q-switched neodymium-yttrium aluminium-garnet (Q switched Nd-Yag) laser has been used in the treatment of nevus of Ota in all skin types with variable success rate. Data with an objective assessment parameter to this laser treatment is lacking. Objective: To evaluate the utility of melanin index in assessing the treatment response and also determine the efficacy and safety of the Q-switched Nd-Yag laser (1064-nm) in the treatment of nevus of Ota in Fitzpatrick skin types IV and V. Materials and Methods: A total of 35 patients treated with Nd-Yag laser were studied. The objective improvement (pigment clearance) was determined by melanin index from two fixed points: A1, 2 cm below the pupil at the mid pupillary line (when the gaze is fixed); A2, the most prominent part of zygoma. The melanin index in these two areas was recorded as M1 and M2, respectively. The subjective clinical improvement was determined by the physician and the patient global assessment score. Results: The mean baseline melanin indices M1 and M2 were 59.54 ± 9.72 and 59.02 ± 9.16, respectively. At the last visit the mean M1 and M2 decreased to 53.8 ± 8.55 (P 50% pigment clearance. Conclusion: The melanin index, a simple non-invasive parameter is useful in assessing the treatment response more objectively. The 1064-nm Q-switched Nd-Yag laser offers good improvement in patients with nevus of Ota in darker skin types IV/V. PMID:24470713

  4. Bilateral Naevus Of OTA

    Directory of Open Access Journals (Sweden)

    Ahmad Qazi Masood

    2001-01-01

    Full Text Available Naevus of Ota is a type of dermal melanocytic naevus characterized by extensive blue patch of dermal melanocytic pigmentation of the sclera and the skin adjacent to the eye. The condition is usually unilateral. Here we report a patient with bilateral naevus of Ota in view of the rarity of this condition.

  5. [Teamwork in the operating theatre: the German Observational Teamwork Assessment for Surgery (OTAS-D) and its first application in Germany].

    Science.gov (United States)

    Passauer-Baierl, S; Chiapponi, C; Bruns, C J; Weigl, M

    2014-12-01

    The quality of surgical teamwork contributes to performance of the operating theatre team, service quality and patient safety in surgery. Observational tools are a feasible and reliable way to capture and evaluate teamwork in the operating theatre (OT). We introduce the German version of the Observational Teamwork Assessment for Surgery (OTAS-D) and present the first observational results from German OTs. Quality of surgical teamwork was assessed with observational teamwork assessment for surgery (OTAS-D). It evaluates five dimensions of OT teamwork: communication, coordination, cooperation/backup behaviour, leadership, and team monitoring/situation awareness. Each dimension is evaluated for each profession (surgical, nursing, and anaesthesia team) as well for each phase of the procedure (pre-, intra-, and post-operative). We observed n = 63 procedures, mainly in abdominal/general and orthopaedic surgery. Additionally, all OT team members scored their individual evaluation of the intra-operative teamwork (standardised 1-item questions). The OTAS-D evaluations showed meaningful results and differences for the OT professions as well as across the different phases of the procedures. Overall, a medium to good level of the OT teamwork was observed. There were no differences in regard to type of surgery (minimally invasive vs. open) or surgical specialties. With an increased coordination of the surgical team we observed a significantly increased cooperation of the nursing team (r = 0.36, p = 0.004). Concerning the OT staffs self-reports, the surgical and nursing teams reported higher scores for quality of surgical teamwork during the procedure than their anaesthesia team members. No significant relationships between observed quality of OT teamwork and self-reports were found. The German version of OTAS-D is a psychometrically robust method to capture the quality of teamwork in operating theatres. It enables the analyses of teamwork between the surgical

  6. Impact of gate-source/drain channel architecture on the performance of an operational transconductance amplifier (OTA)

    Science.gov (United States)

    Kranti, Abhinav; Rashmi; Armstrong, G. Alastair

    2009-11-01

    In this work, we report on the significance of gate-source/drain extension region (also known as underlap design) optimization in double gate (DG) FETs to improve the performance of an operational transconductance amplifier (OTA). It is demonstrated that high values of intrinsic voltage gain (AVO_OTA) > 55 dB and unity gain frequency (fT_OTA) ~ 57 GHz in a folded cascode OTA can be achieved with gate-underlap channel design in 60 nm DG MOSFETs. These values correspond to 15 dB improvement in AVO_OTA and three fold enhancement in fT_OTA over a conventional non-underlap design. OTA performance based on underlap single gate SOI MOSFETs realized in ultra-thin body (UTB) and ultra-thin body BOX (UTBB) technologies is also evaluated. AVO_OTA values exhibited by a DG MOSFET-based OTA are 1.3-1.6 times higher as compared to a conventional UTB/UTBB single gate OTA. fT_OTA values for DG OTA are 10 GHz higher for UTB OTAs whereas a twofold improvement is observed with respect to UTBB OTAs. The simultaneous improvement in AVO_OTA and fT_OTA highlights the usefulness of underlap channel architecture in improving gain-bandwidth trade-off in analog circuit design. Underlap channel OTAs demonstrate high degree of tolerance to misalignment/oversize between front and back gates without compromising the performance, thus relaxing crucial process/technology-dependent parameters to achieve 'idealized' DG MOSFETs. Results show that underlap OTAs designed with a spacer-to-straggle (s/σ) ratio of 3.2 and operated below a bias current (IBIAS) of 80 µA demonstrate optimum performance. The present work provides new opportunities for realizing future ultra-wide band OTA design with underlap DG MOSFETs.

  7. Bilateral familial nevus of Ota.

    Science.gov (United States)

    Goyal, Sunali; Uwaydat, Sami H; Phillips, Paul H; Schaefer, G Bradley

    2014-12-01

    Nevus of Ota is a benign congenital melanocytic lesion found most commonly in people of Asian ancestry. It is associated with an increased risk of glaucoma and uveal melanomas. Most cases are sporadic and unilateral. We present the first reported case of a brother and sister with familial, bilateral nevus of Ota.

  8. Familial nevus of ota

    Directory of Open Access Journals (Sweden)

    Kumari Rashmi

    2006-01-01

    Full Text Available A 23-year-old pregnant woman with an asymptomatic unilateral, bluish, pigmented lesion on her left periocular skin was referred from the obstetrics department for dermatological evaluation. Dermatologic examination revealed unilateral, blue-gray, poorly defined macule on the periorbital skin of the left side of the face mainly over the malar prominence and left temple not crossing the midline, conforming to the maxillary division of trigeminal nerve distribution. The pigmentation was speckled with interspersed dark-brownish elements. Her father, a 47 - year- old man had a similar pigmentation at the same site over the malar prominence of face not extending onto the forehead. Here we report two cases of nevus of Ota occurring in 2 generations of the same family for its rarity.

  9. Assessments of natural radioactivity and determination of heavy metals in soil around industrial dumpsites in Sango-Ota, Ogun state, Nigeria

    Directory of Open Access Journals (Sweden)

    Augustine Kolapo Ademola

    2014-01-01

    Full Text Available The activity concentration of natural radionuclides in soil samples from industrial dumpsites in Sango-Ota were determined using gamma-ray spectrometry with NaI(Tl detector. The mean activity concentration of 226 Ra, 232 Th and 40 K was 3.0 ± 1.2, 33.3 ± 9.8 and 122.1 ± 20.6 Bqkg−1 , respectively. Radium equivalent activities were calculated to assess the hazards arising from the use of the soil sample in agriculture. All the calculated values were lower than the world average. The mean concentration of heavy metals in the soil samples were 33.6, 2.9, 3.8, 2.7, 48.9, 1,5, 34.5 and 0.8 mg l -1 for Cu, Mg, Ca, P, Fe, Pb, Zn and Cd, respectively. The concentrations of Cd, Cu and Pb were higher than the natural permissible range in soil. Therefore, the government should discourage the use of the soil around dumpsites for planting because of the presence of heavy metals in the sites.

  10. Nevus of Ota in children.

    Science.gov (United States)

    Sinha, Smeeta; Cohen, Philip J; Schwartz, Robert A

    2008-07-01

    Nevus of Ota, synonymously termed oculodermal melanosis, is an uncommon dermal melanosis most commonly seen at birth in children of Japanese descent, though it can affect individuals of any age or ethnicity. The disease tends to persist and extend locally, becoming increasingly prominent with age, puberty, and postmenopausal state. Treatment should begin early after diagnosis using multiple sessions of laser photothermolysis to avoid darkening and extension of the lesion. Important associated disorders include ipsilateral glaucoma; intracranial melanocytosis; and rarely cutaneous, ocular, or intracranial melanoma. Recommendations are discussed for managing nevus of Ota in children.

  11. OTA a wide common mode low power

    Directory of Open Access Journals (Sweden)

    Héctor Iván Gómez-Ortiz

    2016-07-01

    Full Text Available This paper presents the design of an operational transconductance amplifier OTA operating in sub-threshold region for low power consumption. Simulations were performed in SYNOPSYS tools program for a 180nm technology. The differential amplifier is supplied with a VDD of 600mV, and has a load capacitance of 15pF. Amplifier gain is 60.08dB with unity-gain frequency of 21.7kHz, and a phase margin greater than 50degrees. Wide common mode operation is achieved by using complementary input differential pairs (NMOS and PMOS showing a range of operation of 500mV.

  12. Gate-all-around OTA`s for rad-hard and high-temperature analog applications

    Energy Technology Data Exchange (ETDEWEB)

    Vandooren, A.; Colinge, J.P. [Univ. of California, Davis, CA (United States). Dept. of Electrical and Computer Engineering; Flandre, D. [Univ. Catholique de Louvain, Louvain-La-Neuve (Belgium). Lab. de Microelectronique

    1999-08-01

    Performance of operational transconductance amplifiers (OTA`s) fabricated in the gate-all-around SOI technology is described at elevated temperature and after total dose irradiation. Design guidelines using two analog parameters (early voltage and transconductance to drain current ratio) are proposed for correct operation in these two different harsh environments. The design methodology using the two analog parameters of interest is proposed and applied to the specific case of the GAA technology. The temperature and dose dependence of the two above design parameters are then presented. Two different OTA architectures are considered: a single-stage amplifier and a folded cascode amplifier. Experimental results obtained separately for each environment are discussed. High-temperature measurements were performed up to 300 C, while total dose measurements were obtained for doses up to 15 Mrad(Si) total dose of gamma rays from a {sup 60}Co source.

  13. A Design of Sigma-Delta ADC Using OTA

    Directory of Open Access Journals (Sweden)

    Miss. Niveditha Yadav M

    2017-06-01

    Full Text Available Sigma-Delta Analog-to-Digital converter (ADC, is widely used in portable electronic products. An operational transconductance amplifier (OTA is one of the most important components of ADC. This paper presents a new design of two stages OTA. The design incorporates Sleep insertion technique and leakage feedback current approach for improving design parameters such as gain, and power as compared to earlier work. The design is simulated in 0.18µm CMOS technology with supply voltage 1.8V.

  14. MIMO Throughput Effectiveness for Basic MIMO OTA Compliance Testing

    Directory of Open Access Journals (Sweden)

    Adoración Marín-Soler

    2012-01-01

    Full Text Available During the March 2011 meeting of the CTIA MIMO OTA Subgroup (MOSG, the members agreed that the subgroup should first determine “what” aspects of a MIMO-capable device require evaluation; then the group should determine “how” to go about making these measurements. In subsequent meetings of MOSG, new yet-unnamed figures of merit were asked for in order to provide a solution to the carriers' requirements for LTE MIMO OTA evaluation. Furthermore, the December 2011 3GPP RAN4 status report on LTE MIMO OTA listed the evaluation of the use of statistical performance analysis in order to minimize test time and help ensure accurate performance assessment as an open issue. This contribution addresses these petitions by providing four new figures of merit, which could serve the purpose of evaluating the operators' top priorities for MIMO OTA compliance testing. The new figures of merit are MIMO Throughput Effectiveness (MTE, MIMO Device Throughput Effectiveness (MDTE, MIMO Throughput Gain (MTG, and MIMO Device Throughput Gain (MDTG. In this paper, MTE is evaluated using the recently available LTE MIMO OTA RR data from 3GPP.

  15. Pruritic acquired nevus of Ota.

    Science.gov (United States)

    Quenan, S; Strueven, V; Saxer, N; Laffitte, E; Kaya, G; Krischer, J; Hafezi, F; Le Gal, F-A

    2013-01-01

    Nevus of Ota is a unilateral, asymptomatic cutaneous and mucosal hyperpigmentation of the face that is congenital or may appear during childhood. We present a case of symptomatic acquired nevus of Ota in an adult, associated with intense pruritus, not described in the literature so far. A 32-year-old woman presented with brownish mottled macules which appeared on her face progressively over 8 days, following the distribution of the first and second divisions of the left trigeminal nerve and partially covering the iris and sclera of the left eye. She reported an intense pruritus in this area. We performed a biopsy on the left forehead, which confirmed the diagnosis of nevus of Ota. Specific stains and immunohistochemistry revealed increased numbers of mast cells. Ophthalmological tests showed acute acquired melanocytosis of the left iris and sclera. The origin of the nevus is still unclear. Several hypotheses suggest a reactivation of melanocytes during their migration from the neural crest. The pruritus reported in our patient may be explained by the increased quantity of mast cells observed in the lesion and/or neuronal stimulation of the ophthalmic and maxillary divisions of the fifth cranial nerve.

  16. Advocacy and technology assessment

    Science.gov (United States)

    Jones, E. M.

    1975-01-01

    A highly structured treatment is presented of adversarial systems as they apply to technology assessment. One approach to the problem of adequate criteria of assessment focuses upon the internal operations of assessment entities; operations include problem perception, problem formulation, selection, utilization, determination, and evaluation. Potential contributions of advocacy as a mode of inquiry in technology are discussed; advocacy is evaluated by representative sets of criteria of adequate assessment which include participant criteria, perspectives criteria, situations criteria, base values criteria, and strategies criteria.

  17. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. [ed.

    1992-01-01

    This year`s Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  18. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. (ed.)

    1992-01-01

    This year's Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  19. Health care technology assessment

    Science.gov (United States)

    Goodman, Clifford

    1994-12-01

    The role of technology in the cost of health care is a primary issue in current debates concerning national health care reform. The broad scope of studies for understanding technological impacts is known as technology assessment. Technology policy makers can improve their decision making by becoming more aware, and taking greater advantage, of key trends in health care technology assessment (HCTA). HCTA is the systematic evaluation of the properties, impacts, and other attributes of health care technologies, including: technical performance; clinical safety and efficacy/effectiveness; cost-effectiveness and other economic attributes; appropriate circumstances/indications for use; and social, legal, ethical, and political impacts. The main purpose of HCTA is to inform technology-related policy making in health care. Among the important trends in HCTA are: (1) proliferation of HCTA groups in the public and private sectors; (2) higher standards for scientific evidence concerning technologies; (3) methodological development in cost analyses, health-related quality of life measurement, and consolidation of available scientific evidence (e.g., meta-analysis); (4) emphasis on improved data on how well technologies work in routine practice and for traditionally under-represented patient groups; (5) development of priority-setting methods; (6) greater reliance on medical informatics to support and disseminate HCTA findings.

  20. Two-Stage Over-the-Air (OTA Test Method for LTE MIMO Device Performance Evaluation

    Directory of Open Access Journals (Sweden)

    Ya Jing

    2012-01-01

    Full Text Available With MIMO technology being adopted by the wireless communication standards LTE and HSPA+, MIMO OTA research has attracted wide interest from both industry and academia. Parallel studies are underway in COST2100, CTIA, and 3GPP RAN WG4. The major test challenge for MIMO OTA is how to create a repeatable scenario which accurately reflects the MIMO antenna radiation performance in a realistic wireless propagation environment. Different MIMO OTA methods differ in the way to reproduce a specified MIMO channel model. This paper introduces a novel, flexible, and cost-effective method for measuring MIMO OTA using a two-stage approach. In the first stage, the antenna pattern is measured in an anechoic chamber using a nonintrusive approach, that is without cabled connections or modifying the device. In the second stage, the antenna pattern is convolved with the chosen channel model in a channel emulator to measure throughput using a cabled connection.

  1. A CMOS OTA for HF filters with programmable transfer function

    NARCIS (Netherlands)

    van de Zwan, Eric J.; Klumperink, Eric A.M.; Seevinck, E.; Seevinck, Evert

    1991-01-01

    A CMOS operational transconductance amplifier (OTA) for programmable HF filters is presented. When used in an OTA-C integrator, the unity-gain frequency phase error remains less than 0.3° for frequencies up to more than one tenth of the OTA bandwidth. The OTA has built-in phase compensation, which

  2. Information Technology Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    The Information Technology Resources Assessment (ITRA) is being published as a companion document to the Department of Energy (DOE) FY 1994--FY 1998 Information Resources Management Long-Range Plan. This document represents a collaborative effort between the Office of Information Resources Management and the Office of Energy Research that was undertaken to achieve, in part, the Technology Strategic Objective of IRM Vision 21. An integral part of this objective, technology forecasting provides an understanding of the information technology horizon and presents a perspective and focus on technologies of particular interest to DOE program activities. Specifically, this document provides site planners with an overview of the status and use of new information technology for their planning consideration.

  3. Technologies for Language Assessment.

    Science.gov (United States)

    Burstein, Jill; And Others

    1996-01-01

    Reviews current and developing technology uses that are relevant to language assessment and discusses examples of recent linguistic applications from the laboratory at the Educational Testing Service. The processes of language test development are described and the functions they serve from the perspective of a large testing organization are…

  4. OTA-Grapes: A Mechanistic Model to Predict Ochratoxin A Risk in Grapes, a Step beyond the Systems Approach

    Directory of Open Access Journals (Sweden)

    Battilani Paola

    2015-08-01

    Full Text Available Ochratoxin A (OTA is a fungal metabolite dangerous for human and animal health due to its nephrotoxic, immunotoxic, mutagenic, teratogenic and carcinogenic effects, classified by the International Agency for Research on Cancer in group 2B, possible human carcinogen. This toxin has been stated as a wine contaminant since 1996. The aim of this study was to develop a conceptual model for the dynamic simulation of the A. carbonarius life cycle in grapes along the growing season, including OTA production in berries. Functions describing the role of weather parameters in each step of the infection cycle were developed and organized in a prototype model called OTA-grapes. Modelling the influence of temperature on OTA production, it emerged that fungal strains can be shared in two different clusters, based on the dynamic of OTA production and according to the optimal temperature. Therefore, two functions were developed, and based on statistical data analysis, it was assumed that the two types of strains contribute equally to the population. Model validation was not possible because of poor OTA contamination data, but relevant differences in OTA-I, the output index of the model, were noticed between low and high risk areas. To our knowledge, this is the first attempt to assess/model A. carbonarius in order to predict the risk of OTA contamination in grapes.

  5. OTA-Grapes: A Mechanistic Model to Predict Ochratoxin A Risk in Grapes, a Step beyond the Systems Approach.

    Science.gov (United States)

    Paola, Battilani; Marco, Camardo Leggieri

    2015-08-06

    Ochratoxin A (OTA) is a fungal metabolite dangerous for human and animal health due to its nephrotoxic, immunotoxic, mutagenic, teratogenic and carcinogenic effects, classified by the International Agency for Research on Cancer in group 2B, possible human carcinogen. This toxin has been stated as a wine contaminant since 1996. The aim of this study was to develop a conceptual model for the dynamic simulation of the A. carbonarius life cycle in grapes along the growing season, including OTA production in berries. Functions describing the role of weather parameters in each step of the infection cycle were developed and organized in a prototype model called OTA-grapes. Modelling the influence of temperature on OTA production, it emerged that fungal strains can be shared in two different clusters, based on the dynamic of OTA production and according to the optimal temperature. Therefore, two functions were developed, and based on statistical data analysis, it was assumed that the two types of strains contribute equally to the population. Model validation was not possible because of poor OTA contamination data, but relevant differences in OTA-I, the output index of the model, were noticed between low and high risk areas. To our knowledge, this is the first attempt to assess/model A. carbonarius in order to predict the risk of OTA contamination in grapes.

  6. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Loken, S.C. [ed.

    1993-01-01

    The emphasis in Information Technology (IT) development has shifted from technology management to information management, and the tools of information management are increasingly at the disposal of end-users, people who deal with information. Moreover, the interactive capabilities of technologies such as hypertext, scientific visualization, virtual reality, video conferencing, and even database management systems have placed in the hands of users a significant amount of discretion over how these resources will be used. The emergence of high-performance networks, as well as network operating systems, improved interoperability, and platform independence of applications will eliminate technical barriers to the use of data, increase the power and range of resources that can be used cooperatively, and open up a wealth of possibilities for new applications. The very scope of these prospects for the immediate future is a problem for the IT planner or administrator. Technology procurement and implementation, integration of new technologies into the existing infrastructure, cost recovery and usage of networks and networked resources, training issues, and security concerns such as data protection and access to experiments are just some of the issues that need to be considered in the emerging IT environment. As managers we must use technology to improve competitiveness. When procuring new systems, we must take advantage of scalable resources. New resources such as distributed file systems can improve access to and efficiency of existing operating systems. In addition, we must assess opportunities to improve information worker productivity and information management through tedmologies such as distributed computational visualization and teleseminar applications.

  7. Photovoltaic technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Backus, C.E.

    1981-01-01

    After a brief review of the history of photovoltaic devices and a discussion of the cost goals set for photovoltaic modules, the status of photovoltaic technology is assessed. Included are discussions of: current applications, present industrial production, low-cost silicon production techniques, energy payback periods for solar cells, advanced materials research and development, concentrator systems, balance-of-system components. Also discussed are some nontechnical aspects, including foreign markets, US government program approach, and industry attitudes and approaches. (LEW)

  8. Nevus of Ota: clinical-ophthalmological findings

    OpenAIRE

    Sebastião Cronemberger; Nassim Calixto; Henrique Leite Freitas

    2011-01-01

    OBJECTIVE: To analyze the clinical and ophthalmological findings of patients with nevus of Ota. METHODS: Retrospective analysis of patients' charts with nevus of Ota. We registered the demographic data, location of the nevus and date of appearance, family history of similar spots, biomicroscopic, gonioscopic, tonometric, ophthalmoscopic and perimetric findings. RESULTS: We included 14 patients, six (43.0%) men and eight (57.0%) women, with a mean age of 21.7±17.5 years. Ten (71%) were mulatt...

  9. BETWEEN EGWU-OTA, TRADITIONAL POLITICAL INSTITUTIONS ...

    African Journals Online (AJOL)

    ethnological field study methodology of interviews, historical analysis and observational ... festivals, Egwu-Ota is performed in the house of the most senior Obi in the ... as music to which people dance in felicitation with the Eze and his first wife.

  10. A High-Swing OTA with wide Linearity for design of self-tunable linear resistor

    Directory of Open Access Journals (Sweden)

    Nikhil Raj

    2015-09-01

    Full Text Available Low power consumption, long battery life and portability are essential requirements of modern health monitoring products. Operational Trans-conductance Amplifier (OTA operating in sub threshold region is an basic building block for low power health monitoring products design. An modified design of OTA which incorporates better linearity and increased output impedance has been discussed in this paper. The proposed OTA uses High-swing improved-Wilson current mirror for low power and low-frequency applications. The achieved linearity is about ± 1.9 volt and unity gain bandwidth (UGB of 342.30 KHz at power supply of 0.9 volt which makes OTA to consume power in range of nanowatts. The proposed lowvoltage OTA implementation in design of self- tunable linear resistor has been presented in this paper. The circuit implementation has been done using standard 0.18 micron technology provided by TSMC on BSIM3v3 level-53 model parameter and verified results through use of ELDO Simulator.

  11. Acquired, bilateral nevus of Ota-like macules (ABNOM) associated with Ota's nevus: case report.

    Science.gov (United States)

    Park, Jung Hun; Lee, Mu Hyoung

    2004-08-01

    Ota's nevus is mongolian spot-like macular blue-black or gray-brown patchy pigmentation that most commonly occurs in areas innervated by the first and second division of the trigeminal nerve. Acquired, bilateral nevus of Ota-like macules (ABNOM) is located bilaterally on the face, appears later in life, is blue-brown or slate-gray in color. It is not accompanied by macules on the ocular and mucosal membranes. There is also debate as to whether ABNOM is part of the Ota's nevus spectrum. We report an interesting case of ABNOM associated with Ota's nevus. A 36-yr-old Korean women visited our clinic with dark bluish patch on the right cheek and right conjunctiva since birth. She also had mottled brownish macules on both forehead and both lower eyelids that have developed 3 yr ago. Skin biopsy specimens taken from the right cheek and left forehead all showed scattered, bipolar or irregular melanocytes in the dermis. We diagnosed lesion on the right cheek area as Ota's nevus and those on both forehead and both lower eyelids as ABNOM by clinical and histologic findings. This case may support the view that ABNOM is a separate entity from bilateral Ota's nevus.

  12. Technology assessment heat pumps

    Energy Technology Data Exchange (ETDEWEB)

    Rudolph, R.; Purper, G. (Battelle-Institut e.V., Frankfurt am Main (Germany, F.R.))

    Technology assessment for an increased application of heat pumps is carried out in four areas: Effects in the economics area, i.e. effects on the economic goals which are defined in the Stability Law, on the goals of the power supply policy which result from the energy programme and its projections, and on the economic structure as a whole. The whole range of social problems concerning the use of heat pumps, i.e. the questions which social groups are affected, how they react, and what consequences are they expected to have on energy conservation as an object of social policy. Consequences in the governmental and administrative sectors, i.e. effects on legislation, administration and government budgets. Effects on the ecological systems; of prime interest in this context are the utilisation of environmental energy, changes in the heat balance, and emmission of pollutants.

  13. A new classification of nevus of Ota

    Institute of Scientific and Technical Information of China (English)

    HUANG Wen-hui; WANG Hong-wei; SUN Qiu-ning; JIN Hong-zhong; LIU Yue-hua; MA Dong-lai; ZUO Ya-gang

    2013-01-01

    Background The nevus of Ota,is a common benign pigmentary dermatosis,mainly involve innervation area of first and second branch of trigeminal nerve.The classification of nevus of Ota was proposed by Tanino,based on 26 cases of nevus of Ota from 1937 to 1940.Studies about its classification are rarely seen in last 70 years,while it is still practical today.Methods Based on the clinical photographs,1079 consecutive patients with nevus of Ota were verified and reclassified according to the innervation areas of the trigeminal nerve branches.Results In these 1079 cases,866 patients were in line with Tanino's classification (80.26%),and 213 patients were not (19.74%).We put forward a new clinical classification (Peking Union Medical College Hospital classification,PUMCH classification) of nevus of Ota based on the innervation area of the trigeminal nerve branches,composed of 5 types and 14 subtypes.The 5 types were as follows:Type Ⅰ-pigmentation maculeses involving the innervation area of one of the three trigeminal nerve branches,of which there were 424 cases (39.3%),comprising 6 subtypes; Type Ⅱ-pigmentation macules involving the innervation area of two branches of the three trigeminal nerve branches,of which there were 221 cases (20.48%),comprising 4 subtypes; Type Ⅲ — pigmentation macules involving the innervation area of all three trigeminal nerve branches,of which there were 361 cases (33.45%),comprising 2 subtypes; Type Ⅳ-bilateral type,in which the pigmentation macules involves the bilateral cheek,of which there were 63 cases (5.84%),comprising 2 subtypes; and Type Ⅴ-complications occurred in the patient,of which there were 10 cases (0.93%).Conclusion The new classification of nevus of Ota is based on the innervation area of the trigeminal nerve branches,and it covers all types of Tanino's classifications; on that basis,some new types and subtypes are brought in and cover almost every clinical condition.

  14. Nevus of Ota: clinical-ophthalmological findings

    Directory of Open Access Journals (Sweden)

    Sebastião Cronemberger

    2011-10-01

    Full Text Available OBJECTIVE: To analyze the clinical and ophthalmological findings of patients with nevus of Ota. METHODS: Retrospective analysis of patients' charts with nevus of Ota. We registered the demographic data, location of the nevus and date of appearance, family history of similar spots, biomicroscopic, gonioscopic, tonometric, ophthalmoscopic and perimetric findings. RESULTS: We included 14 patients, six (43.0% men and eight (57.0% women, with a mean age of 21.7±17.5 years. Ten (71% were mulatto, three (21.4% white and one (7.1% black. Twelve (85.7% patients presented the spots at birth and two in puberty. Nine patients presented conjunctival and episcleral pigmentation in the right eye and five in the left eye. According to Tanino's classification, five (35.7% nevi were class 1, eight (57.1% class 2 and one (7.1% class 3. Heterochromia iridis was found in eight (57.1% patients. Anisocoria was present in three (21.4% patients. Five (35.7% patients presented a suspected glaucomatous cup disc ratio (≥0.7; six (42.9% presented a cup disc ratio ≤ 0.5 and three (21.4%, no cup disc. We found two curious and remarkable findings: a nevus of Ota on the palate of one patient and other on the optic disc associated with a pigmentary mottling of the fundus in another patient. The pigmentary mottling of the fundus was also seen in four more eyes. CONCLUSIONS: The nevus of Ota was frequently present at birth, in mulattos, and classified as Tanino's class 1 and 2. Heterochromia iridis was a common finding. Anisocoria was present in a small percentage of eyes. No patient developed glaucoma or malignancy.

  15. Technology Performance Level Assessment Methodology.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Jesse D.; Bull, Diana L; Malins, Robert Joseph; Costello, Ronan Patrick; Aurelien Babarit; Kim Nielsen; Claudio Bittencourt Ferreira; Ben Kennedy; Kathryn Dykes; Jochem Weber

    2017-04-01

    The technology performance level (TPL) assessments can be applied at all technology development stages and associated technology readiness levels (TRLs). Even, and particularly, at low TRLs the TPL assessment is very effective as it, holistically, considers a wide range of WEC attributes that determine the techno-economic performance potential of the WEC farm when fully developed for commercial operation. The TPL assessment also highlights potential showstoppers at the earliest possible stage of the WEC technology development. Hence, the TPL assessment identifies the technology independent “performance requirements.” In order to achieve a successful solution, the entirety of the performance requirements within the TPL must be considered because, in the end, all the stakeholder needs must be achieved. The basis for performing a TPL assessment comes from the information provided in a dedicated format, the Technical Submission Form (TSF). The TSF requests information from the WEC developer that is required to answer the questions posed in the TPL assessment document.

  16. Comparative study of growth responses and screening of inter-specific OTA production kinetics by A. carbonarius isolated from grapes

    Directory of Open Access Journals (Sweden)

    Iliada eLappa

    2015-05-01

    Full Text Available The aim of this work was to assess OchratoxinA (OTA production of different Aspergillus carbonarius isolates, evaluate their growth profile through different growth measurements, and reveal any underlying correlation between them. Ten different isolates of A. carbonarius isolated from Greek vineyards located in different geographical regions were examined in vitro for their OTA production potential after an incubation period of up to 11 days. All fungal isolates grew on a synthetic grape juice medium (SGM similar to grape composition at optimum conditions of temperature and water activity (25°C and 0.98 aw. Samples for OTA determination were removed at 3, 5, 7, 9 and 11 days of growth and analyzed by HPLC. Based on OTA measurements the isolates were characterized by diverse OTA production ranging from 50-2000 ppb at day 11. The different fungal growth responses (colony diameter, colony area, biomass, biomass dry weight, and colony density have been measured and correlated with toxin production by means of principal components analysis (PCA, confirming satisfactory correlation and explained over 99% of data variability. Leudeking-Piret model was also used to study OTA production with time, revealing a mixed-growth associated trend and pointing a fail-safe model with slightly better prediction through colony area. This approach contributes to the assessment of correlation between mycotoxin production and different methods of fungal growth determination in relation to time.

  17. Comparative study of growth responses and screening of inter-specific OTA production kinetics by A. carbonarius isolated from grapes

    Science.gov (United States)

    Lappa, Iliada K.; Kizis, Dimosthenis; Natskoulis, Pantelis I.; Panagou, Efstathios Z.

    2015-01-01

    The aim of this work was to assess OchratoxinA (OTA) production of different Aspergillus carbonarius isolates, evaluate their growth profile through different growth measurements, and reveal any underlying correlation between them. Ten different isolates of A. carbonarius isolated from Greek vineyards located in different geographical regions were examined in vitro for their OTA production potential after an incubation period of up to 11 days. All fungal isolates grew on a synthetic grape juice medium (SGM) similar to grape composition at optimum conditions of temperature and water activity (25°C and 0.98 aw). Samples for OTA determination were removed at 3, 5, 7, 9, and 11 days of growth and analyzed by HPLC. Based on OTA measurements the isolates were characterized by diverse OTA production ranging from 50 to 2000 ppb at day 11. The different fungal growth responses (colony diameter, colony area, biomass, biomass dry weight, and colony density) have been measured and correlated with toxin production by means of principal components analysis (PCA), confirming satisfactory correlation and explained over 99% of data variability. Leudeking-Piret model was also used to study OTA production with time, revealing a mixed-growth associated trend and pointing a fail-safe model with slightly better prediction through colony area. This approach contributes to the assessment of correlation between mycotoxin production and different methods of fungal growth determination in relation to time. PMID:26074896

  18. Low Power Low Voltage Bulk Driven Balanced OTA

    Directory of Open Access Journals (Sweden)

    Neha Gupta

    2012-01-01

    Full Text Available The last few decades, a great deal of attention has been paid to low-voltage (LV low-power (LP integrated circuits design since the power consumption has become a critical issue. Among many techniques used for the design of LV LP analog circuits, the Bulk-driven principle offers a promising route towards this design for many aspects mainly the simplicity and using the conventional MOS technology to implement these designs. This paper is devoted to the Bulk-driven (BD principle and utilizing this principle to design LV LP building block of Operational Transconductance Amplifier (OTA in standard CMOS processes and supply voltage 0.9V. The simulation results have been carried out by the Spice simulatorusing the 130nm CMOS technology from TSMC.

  19. Low Power Low Voltage Bulk Driven Balanced OTA

    Directory of Open Access Journals (Sweden)

    Neha Gupta

    2011-12-01

    Full Text Available The last few decades, a great deal of attention has been paid to low-voltage (LV low-power (LP integrated circuits design since the power consumption has become a critical issue. Among many techniques used for the design of LV LP analog circuits, the Bulk-driven principle offers a promising route towards this design for many aspects mainly the simplicity and using the conventional MOS technology to implement these designs. This paper is devoted to the Bulk-driven (BD principle and utilizing this principle to design LV LP building block of Operational Trans conductance Amplifier (OTA in standard CMOS processes and supply voltage 0.9 V. The simulation results have been carried out by the Spice simulator using the 130 nm CMOS technology from TSMC.

  20. Low Power Low Voltage Bulk Driven Balanced OTA

    CERN Document Server

    Gupta, Neha; Suthar, Meenakshi; Soni, Priyanka

    2012-01-01

    The last few decades, a great deal of attention has been paid to low-voltage (LV) low-power (LP) integrated circuits design since the power consumption has become a critical issue. Among many techniques used for the design of LV LP analog circuits, the Bulk-driven principle offers a promising route towards this design for many aspects mainly the simplicity and using the conventional MOS technology to implement these designs. This paper is devoted to the Bulk-driven (BD) principle and utilizing this principle to design LV LP building block of Operational Transconductance Amplifier (OTA) in standard CMOS processes and supply voltage 0.9V. The simulation results have been carried out by the Spice simulator using the 130nm CMOS technology from TSMC.

  1. Low Power Folded Cascode OTA

    Directory of Open Access Journals (Sweden)

    Swati Kundra

    2012-03-01

    Full Text Available Low power is one of the key research area in today’s electronic industry. Need of low power has created a major pattern shift in the field of electronics where power dissipation is equally important as area, performance etc. Several low power portable electronic equipments, low voltage design techniques havebeen developed and have driven analog designers to create techniques eg. Self cascode mosfet and stacking technique. For this aim in mind we designed a Folded Cascode using low power techniques and analyzed its various properties through the Spice simulations for 0.13 micron CMOS technology from TSMC and thesupply voltage 1.8V.

  2. Low Power Folded Cascode OTA

    Directory of Open Access Journals (Sweden)

    Swati Kundra

    2012-02-01

    Full Text Available Low power is one of the key research area in today’s electronic industry. Need of low power has created a major pattern shift in the field of electronics where power dissipation is equally important as area, performance etc. Several low power portable electronic equipments, low voltage design techniques have been developed and have driven analog designers to create techniques eg. Self cascode mosfet and stacking technique. For this aim in mind we designed a Folded Cascode using low power techniques and analyzed its various properties through the Spice simulations for 0.13 micron CMOS technology from TSMC and the supply voltage 1.8V.

  3. Lasers and nevus of Ota: a comprehensive review.

    Science.gov (United States)

    Shah, Vidhi V; Bray, Fleta N; Aldahan, Adam S; Mlacker, Stephanie; Nouri, Keyvan

    2016-01-01

    Nevus of Ota is a benign dermal melanocytic nevus that typically affects Asian children and women. The nevus presents as unilateral blue-gray hyperpigmented macules and patches scattered along the first and second divisions of the trigeminal nerve. Individuals with nevus of Ota experience emotional and psychosocial distress related to cosmetic disfigurement and often look for treatment options. Unfortunately, even when treated early, lesions of nevus of Ota are still difficult to treat. The use of lasers for the treatment of nevus of Ota lesions has become helpful in the management of dermal nevi. Currently, Q-switched (QS) lasers have been the most studied and demonstrated positive results for treatment of nevus of Ota. The purpose of this review article is to summarize the clinical efficacy and side effects associated with QS lasers and the treatment of nevus of Ota lesions.

  4. Melter Technologies Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Perez, J.M. Jr. [Pacific Northwest National Lab., Richland, WA (United States); Schumacher, R.F. [Savannah River Technology Center, Aiken, SC (United States); Forsberg, C.W. [Oak Ridge National Lab., TN (United States)

    1996-05-01

    The problem of controlling and disposing of surplus fissile material, in particular plutonium, is being addressed by the US Department of Energy (DOE). Immobilization of plutonium by vitrification has been identified as a promising solution. The Melter Evaluation Activity of DOE`s Plutonium Immobilization Task is responsible for evaluating and selecting the preferred melter technologies for vitrification for each of three immobilization options: Greenfield Facility, Adjunct Melter Facility, and Can-In-Canister. A significant number of melter technologies are available for evaluation as a result of vitrification research and development throughout the international communities for over 20 years. This paper describes an evaluation process which will establish the specific requirements of performance against which candidate melter technologies can be carefully evaluated. Melter technologies that have been identified are also described.

  5. Turbine imaging technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Moursund, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2004-12-01

    The goal of this project was to identify and evaluate imaging technologies for observing juvenile fish within a Kaplan turbine, and specifically that would enable scientists to determine mechanisms of fish injury within an operating turbine unit. This report documents the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. These observations were used to make modifications to dam structures and operations to improve conditions for fish passage while maintaining or improving hydropower production. The physical and hydraulic environment that fish experience as they pass through the hydroelectric plants were studied and the regions with the greatest potential for injury were defined. Biological response data were also studied to determine the probable types of injuries sustained in the turbine intake and what types of injuries are detectable with imaging technologies. The study grouped injury-causing mechanisms into two categories: fluid (pressure/cavitation, shear, turbulence) and mechanical (strike/collision, grinding/pinching, scraping). The physical constraints of the environment, together with the likely types of injuries to fish, provided the parameters needed for a rigorous imaging technology evaluation. Types of technology evaluated included both tracking and imaging systems using acoustic technologies (such as sonar and acoustic tags) and optic technologies (such as pulsed-laser videography, which is high-speed videography using a laser as the flash). Criteria for determining image data quality such as frame rate, target detectability, and resolution were used to quantify the minimum requirements of an imaging sensor.

  6. Emulating Spatial Characteristics of MIMO Channels for OTA Testing

    DEFF Research Database (Denmark)

    Fan, Wei; Carreño, Xavier; Sun, Fan;

    2013-01-01

    This paper discusses over the air (OTA) testing for multiple input multiple output (MIMO) capable terminals with emphasis on channel spatial characteristics emulation. A novel technique to obtain optimum power weights for the OTA probes based on convex optimization is proposed. The proposed...... performance compared with existing techniques in the literature. This improvement is further demonstrated by measurement results in a practical MIMO OTA setup....

  7. Giant Blue Nevus: A New Association to Nevus of Ota.

    Science.gov (United States)

    Medel, Ramón; Vasquez, LuzMaria; Fernandez, Javier; Huguet, Pere; Pamias, Jordi

    2015-01-01

    Nevus of Ota, also known as oculodermal melanocytosis, is a congenital pigmentary condition that can affect structures in the distribution of the ophthalmic and maxillary divisions of the trigeminal cranial nerve. Malignant transformation, although rare, may occur within nevus of Ota and result in uveal, cutaneous, orbital or even dural melanoma. We present a new association of Nevus of Ota complicated with a giant orbital Blue Nevus in a young white male and the management of this tumor.

  8. A Case of Iris Mammillation Associated with Nevus of Ota

    Directory of Open Access Journals (Sweden)

    Onur Polat

    2013-10-01

    Full Text Available Nevus of Ota is characterized by the presence of hyperpigmentation in the skin areas innervated by the first or the second branches of the trigeminal nerve. Women are affected three times as often as men. Although nevus of Ota is a congenital disorder, it can be seen in puberty or adulthood. Herein a case of nevus of Ota was reported accompanying iris heterochromia and rare iris mammillation. Because of the relationship between iris heterochromia and iris mammillation with glaucoma and especially uveal melanoma, all the patients with nevus of Ota should be monitored closely with regular ophthalmologic examination.

  9. Superconducting Technology Assessment

    Science.gov (United States)

    2005-08-01

    of Nb/Al- Nx /NbTiN junctions for SIS mixer applications,” IEEE Trans. Appl. Superconduct., vol. 11, pp. 76–79, Mar. 2001. [48] M. Gurvitch, W. A...Another connector developed by IBM for commercial applications using a dendritic interposer technology. A “beam-on-pad” approach developed by Siemens

  10. Design of Low-Power CMOS OTA Using Bulk-Drive Technique

    Directory of Open Access Journals (Sweden)

    Maryam Ghadiri Modarres

    2015-10-01

    Full Text Available This paper presents the design of low power CMOS- OTA (operational transconductance amplifier using bulk drive (BD technique with broad band. This technique is used for design of low power circuits with broad band for high frequency users, for example communication systems, mobile communication and communication forming of medical electronics. OTA is the base of amplifier .It is a fundamental building part of analog systems. Recently analog designer has been paid to low voltage (LV,low power (LP integrated circuits. Many techniques are used for the design of LV LP circuits, the bulk driven offers principle this designs. This paper suggests a bulk driven OTA in standard CMOS processes and supply voltage 0.8 volt DC. It used of improved wilson current mirror. The simulation results have been carried out by the HSPICE simulator in 180 nm CMOS technology. The open loop gain is enhanced to 17.4dB at unity gain band with (UGB of 26.1 MHZ with sufficient output swing. Power consumption of the OTA is in range of few hundreds of nanowatts (6%.

  11. Characterization and Comparison of Ochratoxin A-Ovalbumin (OTA-OVA) Conjugation by Three Methods

    Institute of Scientific and Technical Information of China (English)

    WANG Xi-chun; BAO Ming; WU Jin-jie; LUO Ying; MA Liang-you; WANG Ying; ZHANG Ai-hua; HE Cheng-hua; ZHANG Hai-bin

    2014-01-01

    In order to generate an antibody against a small hapten molecule, the hapten is cross-linked with carrier protein to make it immunogenic. In this study, the hapten (ochratoxin A, OTA) was coupled to ovalbumin (OVA) by an active ester reaction. To develop a technique for detecting the conjugation, the hapten-protein conjugate (OTA-OVA) was characterized thoroughly by immunoarray technology, ultraviolet (UV) spectroscopy and matrix-assisted laser desorption ionization time-of-lfight mass spectrometry (MALDI-TOF-MS), respectively. The molecular weight of OTA-OVA was 50 350.141 Da, and the molecular weight of OVA was 44 887.506 Da, which were determined by MALDI-TOF-MS, respectively. In OTA-OVA, the molecular coupling ratio was 13:1 by MALDI-TOF-MS while the molecular coupling ratio was 10:1 by UV. In this experiment, UV and MALDI-TOF-MS were selected as the efifcient methods to evaluate the cross-linking effect and calculate the molecular coupling ratio.

  12. Health technology assessment in Finland

    DEFF Research Database (Denmark)

    Mäkelä, Marjukka; Roine, Risto P

    2010-01-01

    Since the 1990s, health policy makers in Finland have been supportive of evidence-based medicine and approaches to implement its results. The Finnish Office for Health Technology Assessment (Finohta) has grown from a small start in 1995 to a medium-sized health technology assessment (HTA) agency......, with special responsibility in providing assessments to underpin national policies in screening. External evaluations enhanced the rapid growth. In the Finnish environment, decision making on health technologies is extremely decentralized, so Finohta has developed some practical tools for implementing HTA...... findings. The Managed Uptake of Medical Methods program links the hospital districts to agree on introduction of technologies. The Ohtanen database provides Finnish-language summaries of major assessments made in other countries....

  13. Assessing Advanced Technology in CENATE

    Energy Technology Data Exchange (ETDEWEB)

    Tallent, Nathan R.; Barker, Kevin J.; Gioiosa, Roberto; Marquez, Andres; Kestor, Gokcen; Song, Shuaiwen; Tumeo, Antonino; Kerbyson, Darren J.; Hoisie, Adolfy

    2016-08-08

    PNNL's Center for Advanced Technology Evaluation (CENATE) is a new U.S. Department of Energy center whose mission is to assess and facilitate access to emerging computing technology. CENATE is assessing a range of advanced technologies, from evolutionary to disruptive. Technologies of interest include the processor socket (homogeneous and accelerated systems), memories (dynamic, static, memory cubes), motherboards, networks (network interface cards and switches), and input/output and storage devices. CENATE is developing a multi-perspective evaluation process based on integrating advanced system instrumentation, performance measurements, and modeling and simulation. We show evaluations of two emerging network technologies: silicon photonics interconnects and the Data Vortex network. CENATE's evaluation also addresses the question of which machine is best for a given workload under certain constraints. We show a performance-power tradeoff analysis of a well-known machine learning application on two systems.

  14. Antenna Pattern Impact on MIMO OTA Testing

    DEFF Research Database (Denmark)

    Fan, Wei; Nielsen, Jesper Ødum; Franek, Ondrej

    2013-01-01

    This paper investigates the impact of the DUT antenna pattern on the test area performance for multi-probe based MIMO OTA setup in terms of received voltage and spatial correlation. The plane wave synthesis (PWS) technique has been proposed for vertical polarization in the literature, where...... the goal is to approximate plane waves with arbitrary directions. The received voltage at the antenna terminal depends on the antenna radiation pattern and the impinging plane waves. A novel closed form technique to reproduce the received voltage with arbitrary incoming plane waves based on trigonometric...... interpolation is presented. The proposed technique provides a closed form solution for the PWS when the probe ring radius is infinite. The proposed technique shows that the impact of the antenna pattern on the induced received voltage accuracy is ruled by Nyquist sampling theory. Furthermore, the impact...

  15. Health Technology Assessment: Definition, History and Outcome. What Is the Responsibility of ISR in This Field?

    Directory of Open Access Journals (Sweden)

    Kourosh Abdollahifard

    2011-05-01

    Full Text Available Definition: New instrumental medical interventions"nlead to new financial problems and some questions"nmust be answered for service receivers and insurance"ncompanies (payers and scientific, academic and"ngovernmental societies and organs about the safety,"nefficiency and cost of these new procedures."nHistory: 1967 - Technology Assessment first used"nin the Subcommittee on Science, Research, and"nDevelopment of the House Science and Astronautics"nCommittee of the U.S. Congress."n1972 - The U.S. Congress created the (The Office of"nTechnology Assessment (OTA by Public Law 92-484."nOTA provide analysis of the complex scientific and"ntechnical issues from 1972 to 1995."n1987 - Scientific Technology Options Assessment"n(STOA-an official organ of the European Parliament"n- started releasing reports partnering with external"nexperts."n1990 - The European Parliamentary Technology"nAssessment Network-EPTA was formally established"nunder the patronage of the President of the European"nParliament to advise parliaments on the possible social,"neconomic and environmental impact of new sciences"nand technologies. For example, working in the future,"nstructures and trends in industrial work and vaccine"ncapacity in the UK."nIn 1973-1975, roots of Health Technology were"nestablished:"nThe U.S. Academy of Sciences published a report that"nexamined the implications of four health technologies:"nin vitro fertilization, choosing the sex of children,"nretardation of aging, and modifying human behavior"nThe National Institutes of Health carried out a rather"ncomprehensive assessment of the totally implantable artificial heart in 1973."nThe Swedish Organization, Spri, carried out a costeffective"nanalysis of the computed tomography (CT"nscanner (the first HTA outside the US."nOutcome: Accelerated improvement in the medical"ndiagnostic field requires independent reliable medical"nand economic scientists for assessment of the costeffectiveness"nof the new procedures

  16. OTA & CCII-Based Control System of Shunt Active Power Filter Using in Three-Phase Three-wire System

    Science.gov (United States)

    Vanichprapa, Sombat; Prapanavarat, Cherdchai; Chipipop, Boonruk

    2008-10-01

    This paper presents the implementation of the OTA (Operational Transconductance Amplifier) & CCII (Second generation Current Conveyor)—based control system of active power filter (APF). The three-phase shunt PWM VSI-APF is used as the power circuit for simple control. This proposed control system using OTA & CCII-based circuits since it has the advantage of its adaptive control, real-time processing and it has wide bandwidth which can work with the high frequency power switches in order to eliminate the higher order of harmonics, moreover, it can be fabricated in one single chip by using CMOS technology. Theoretical analysis, design and simulation results are provided.

  17. Bilateral Ota nevus in a 15 years old patient

    Directory of Open Access Journals (Sweden)

    Savaş Öztürk

    2013-12-01

    Full Text Available Nevus of Ota is a dermal melanocytosis, clinically localizedon skin that is innervated by the first and secondbranches of the trigeminal nerve. It occurs almost entirelyin Asian people. The clinical manifestations are usuallyunilateral; only 5% of cases are bilateral. In this article,due to rarity of the case, a 15-year-old patient, who was diagnosedwith bilateral ota nevus, without having any dermatologicalcomplaints other than cosmetic appearenceand stains in her eyes and around was presented.Key words: Bilateral ota nevus, child, melanocytosis

  18. Data of evolutionary structure change: 1E52A-4OTAE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E52A-4OTAE 1E52 4OTA A E LEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAA...>0 4OTA E 4OTAE -5.197999954223633 -31.14299964904785 19.062000274658203 tion> -0.972000002861023 0.22200000286102295 tion> 1.9988939762115479 2.805737018585205 ...

  19. Data of evolutionary structure change: 1E52B-4OTAE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E52B-4OTAE 1E52 4OTA B E LEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAA...>0 4OTA E 4OTAE -18.371000289916992 -7.144000053405762 1.434999942779541 tion> 0...>-0.4449999928474426 -0.7960000038146973 tion> 1.9984110593795776 2.8052260875701904 ...

  20. Comparison of characteristics of acquired bilateral nevus of Ota-like macules and nevus of Ota according to therapeutic outcome.

    Science.gov (United States)

    Lee, Bangjin; Kim, You Chan; Kang, Won Hyoung; Lee, Eun-So

    2004-08-01

    Both acquired bilateral nevus of Ota-like macules (ABNOM) and nevus of Ota are characterized by the presence of dermal melanocytes. There are no differences in the method of treatment, however, postinflammatory hyperpigmentation (PIH) develops more often in ABNOM than in nevus of Ota following treatment. We investigated the differences in the development of PIH after treatment between ABNOM and nevus of Ota, and the histopathologic differences in the PIH. A total of 82 patients with ABNOM (n=47) and nevus of Ota (n=35) were treated with Q-switched alexandrite laser and followed up 2 weeks and 3 months later. Biopsies were performed on lesional skin before treatment. The distribution and the amount of melanin pigments were visualized with Fontana-Masson stain, and the distribution and the depth of melanocytes were measured by GP-100 (NK1-beteb) stain. Clinically, there was more erythema and PIH in ABNOM than in nevus of Ota. Histopathologically, intradermal melanocytes were clustered in groups and dispersed perivascularly in ABNOM, while melanocytes were scattered evenly throughout the dermis in nevus of Ota. Both groups show that when there is a statistically significant number of melanocytes in the perivascular area, erythema and PIH occur after laser therapy. In conclusion, indirect vessel injury in addition to perivascular clustering melanocytes might be considered the cause of increased PIH after treatment in ABNOM.

  1. Design and Analysis of CMOS Folded Cascode OTA Using Gm/ID Technique

    Directory of Open Access Journals (Sweden)

    Tapsi Singh

    2012-03-01

    Full Text Available This paper deals with the design and analysis of folded cascode operational transconductance amplifier in different regions of operations: strong, weak and moderate inversion region. The folded cascode OTA consists of cascode OTA and cascode gain boosting technique. By using 0.35µm technology, the simulation shows DC gain of 78.42dB with a unity gain bandwidth of 446.07 MHz and power consumption of 412.77µW in strong inversion mode. The moderate inversion mode has a DC gain of 93dB and it provides unity gain bandwidth of 75.64MHz with a power consumption of 23.72µW. In weak inversion mode, it has 76.84dB DC gain with a unity gain bandwidth of 19.46 MHz and a power consumption of 0.1µW.

  2. Augmented Reality Tower Technology Assessment

    Science.gov (United States)

    Reisman, Ronald J.; Brown, David M.

    2009-01-01

    Augmented Reality technology may help improve Air Traffic Control Tower efficiency and safety during low-visibility conditions. This paper presents the assessments of five off-duty controllers who shadow-controlled' with an augmented reality prototype in their own facility. Initial studies indicated unanimous agreement that this technology is potentially beneficial, though the prototype used in the study was not adequate for operational use. Some controllers agreed that augmented reality technology improved situational awareness, had potential to benefit clearance, control, and coordination tasks and duties and could be very useful for acquiring aircraft and weather information, particularly aircraft location, heading, and identification. The strongest objections to the prototype used in this study were directed at aircraft registration errors, unacceptable optical transparency, insufficient display performance in sunlight, inadequate representation of the static environment and insufficient symbology.

  3. Health technology assessment in Singapore.

    Science.gov (United States)

    Pwee, Keng Ho

    2009-07-01

    The Republic of Singapore is an island city-state in Southeast Asia. Its population enjoys good health and the Singapore Ministry of Health's mission is to promote good health and reduce illness, ensure access to good and affordable health care, and pursue medical excellence. This is achieved through a healthcare system that includes both private and public sector elements. The financing philosophy of Singapore's healthcare delivery system is based on individual responsibility and community support. Health care in Singapore is financed by a combination of taxes, employee medical benefits, compulsory health savings, insurance, and out-of-pocket payment. The capability for health technology assessment in Singapore was developed concurrently with its medical device regulation system in the 1990s. The first formal unit with health technology assessment (HTA) functions was established in September 1995. Today, HTA features in decision making for the Standard Drug List, licensing of medical clinics, the Health Service Development Programme, healthcare subsidies, and policy development. The public sector healthcare delivery clusters have also recently started health services research units with HTA functions. Singapore is organizing the 6th Health Technology Assessment International (HTAi) Annual Meeting in June 2009. Bringing this prestigious international conference to Asia for the first time will help raise awareness of HTA in the region.

  4. Health technology assessment in Mexico.

    Science.gov (United States)

    Gómez-Dantés, Octavio; Frenk, Julio

    2009-07-01

    The history of health technology assessment (HTA) in Mexico is examined, starting with the efforts to incorporate this topic into the policy agenda and culminating with the recent creation of a specialized public agency. Information was gathered through a bibliographic search and interviews with actors involved in HTA in Mexico. HTA efforts were developed in Mexico since the mid-1980s with the participation both of academics and of policy makers, a relationship that eventually led to the creation of the Center for Technological Excellence within the Ministry of Health. Institutionalization of HTA in resource-constrained settings requires the development of a critical mass of researchers involved in this field, the implementation of information efforts, and the establishment of strong relationships between HTA experts and policy makers.

  5. Technology Assessment Report: Aqueous Sludge Gasification Technologies

    Science.gov (United States)

    The study reveals that sludge gasification is a potentially suitable alternative to conventional sludge handling and disposal methods. However, very few commercial operations are in existence. The limited pilot, demonstration or commercial application of gasification technology t...

  6. Evaluation and Assessment in Educational Information Technology.

    Science.gov (United States)

    Liu, Leping, Ed.; Johnson, D. LaMont, Ed.; Maddux, Cleborne D., Ed.; Henderson, Norma J., Ed.

    This book contains the following articles on evaluating and assessing educational information technology: (1) "Assessing Learning in the New Age of Information Technology in Education" (Leping Liu, D. LaMont Johnson, Cleborne D. Maddux, and Norma J. Henderson); (2) "Instruments for Assessing the Impact of Technology in Education" (Rhonda…

  7. HVDC power transmission technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Hauth, R.L.; Tatro, P.J.; Railing, B.D. [New England Power Service Co., Westborough, MA (United States); Johnson, B.K.; Stewart, J.R. [Power Technologies, Inc., Schenectady, NY (United States); Fink, J.L.

    1997-04-01

    The purpose of this study was to develop an assessment of the national utility system`s needs for electric transmission during the period 1995-2020 that could be met by future reduced-cost HVDC systems. The assessment was to include an economic evaluation of HVDC as a means for meeting those needs as well as a comparison with competing technologies such as ac transmission with and without Flexible AC Transmission System (FACTS) controllers. The role of force commutated dc converters was to be assumed where appropriate. The assessment begins by identifying the general needs for transmission in the U.S. in the context of a future deregulated power industry. The possible roles for direct current transmission are then postulated in terms of representative scenarios. A few of the scenarios are illustrated with the help of actual U.S. system examples. non-traditional applications as well as traditional applications such as long lines and asynchronous interconnections are discussed. The classical ``break-even distance`` concept for comparing HVDC and ac lines is used to assess the selected scenarios. The impact of reduced-cost converters is reflected in terms of the break-even distance. This report presents a comprehensive review of the functional benefits of HVDC transmission and updated cost data for both ac and dc system components. It also provides some provocative thoughts on how direct current transmission might be applied to better utilize and expand our nation`s increasingly stressed transmission assets.

  8. Technology modernization assessment flexible automation

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, D.W.; Boyd, D.R.; Hansen, N.H.; Hansen, M.A.; Yount, J.A.

    1990-12-01

    The objectives of this report are: to present technology assessment guidelines to be considered in conjunction with defense regulations before an automation project is developed to give examples showing how assessment guidelines may be applied to a current project to present several potential areas where automation might be applied successfully in the depot system. Depots perform primarily repair and remanufacturing operations, with limited small batch manufacturing runs. While certain activities (such as Management Information Systems and warehousing) are directly applicable to either environment, the majority of applications will require combining existing and emerging technologies in different ways, with the special needs of depot remanufacturing environment. Industry generally enjoys the ability to make revisions to its product lines seasonally, followed by batch runs of thousands or more. Depot batch runs are in the tens, at best the hundreds, of parts with a potential for large variation in product mix; reconfiguration may be required on a week-to-week basis. This need for a higher degree of flexibility suggests a higher level of operator interaction, and, in turn, control systems that go beyond the state of the art for less flexible automation and industry in general. This report investigates the benefits and barriers to automation and concludes that, while significant benefits do exist for automation, depots must be prepared to carefully investigate the technical feasibility of each opportunity and the life-cycle costs associated with implementation. Implementation is suggested in two ways: (1) develop an implementation plan for automation technologies based on results of small demonstration automation projects; (2) use phased implementation for both these and later stage automation projects to allow major technical and administrative risk issues to be addressed. 10 refs., 2 figs., 2 tabs. (JF)

  9. Design of new highly linear OTA for OTA-C filters%适用于OTA-C滤波器的高线性OTA的设计

    Institute of Scientific and Technical Information of China (English)

    余国义; 钟建福; 张乐

    2013-01-01

    A highly linear operational trausonductance amphfier (OTA) was designed for OTA-C filters, in which a new multiplier input stage was adopted to get a high linear trans-conductance input range. Structure limitations in conventional common mode feed bark (CMFB) were addressed with a new common mode feedback strategy, in which the outputs of the OTA linearly were compressed before putting them into CMFB circuits. The simulation result shows that the linear divided input voltage is-2~2 V, and with 1 祍 trans-conductance, the OTA gets a DC-gain of 76 dB, common mode rejection ratio (CMRR) of 140 dB, power suppy rejection ratio(PSRR) of 144 dB, under the SMIC. 35 祄 standard complementary metal-oxide semicondouctor (CMOS) process. Based on such OTA, an OTA-C low-pass butterworth filter was designed. The filter's cut-off frequency can alternate from 11 kHz to 419 kHz with 1 pf capacitance load, and when the cut-off frequency is 100 kHz, the filter gets -47 dB total harmonic distortions with 3 Vp-p@100 kHz output.%设计了一种适用于OTA-C滤波器的高线性运算跨导放大器(OTA).该OTA采用新型的乘法器输入级,以获得大的线性跨导输入范围;采用一种新的共模负反馈(CMFB)策略,将主放大器输出电压线性压缩后再引入CMFB电路,以改善传统CMFB结构对OTA输出线性范围的限制.在SMIC.35 μm标准CMOS工艺下仿真,结果显示:输入级的线性跨导差分输入电压范围达到了—2~2 V,等效跨导在1 μS时,直流(DC)开环增益达到了76 dB,共模抑制比(CMRR)为140 dB,电源抑制比(PSRR)为144 dB.基于这种OTA设计了OTA-C二阶低通巴特沃斯滤波器.通过调节OTA的跨导,滤波器在1 pf的负载电容下的截止频率从11 kHz变化至419 kHz;当截止频率为100 kHz时输出为3 Vp-p@100 kHz时的总谐波失真(THD)为—47 dB.

  10. Technology-assisted dietary assessment

    Science.gov (United States)

    Zhu, Fengqing; Mariappan, Anand; Boushey, Carol J.; Kerr, Deb; Lutes, Kyle D.; Ebert, David S.; Delp, Edward J.

    2008-02-01

    Dietary intake provides valuable insights for mounting intervention programs for prevention of disease. With growing concern for adolescent obesity, the need to accurately measure diet becomes imperative. Assessment among adolescents is problematic as this group has irregular eating patterns and have less enthusiasm for recording food intake. Preliminary studies among adolescents suggest that innovative use of technology may improve the accuracy of diet information from young people. In this paper, we propose a novel food record method using a mobile device that will provide an accurate account of daily food and nutrient intake among adolescents. Our approach includes the use of image analysis tools for identification and quantification of food consumption. Images obtained before and after food is consumed can be used to estimate the diet of an individual. In this paper we describe our initial results and indicate the potential of the proposed system.

  11. Bilateral type of nevus of Ota presenting as agminated lentigines.

    Science.gov (United States)

    Kang, Hee Young; Kang, Won Hyoung

    2003-01-01

    We report a 30-year-old female patient with a history of hyperpigmented macules of the face since the age of 7 years. The clinical appearance, brown macules in multiple segmental or grouped patterns, was suggested to be agminated lentigines. However, histologic examination of the pigmented macule revealed scattered melanocytes within the dermis. We diagnosed this lesion as a bilateral type of nevus of Ota presenting as agminated lentigines. The differential diagnosis from acquired bilateral nevus of Ota-like macules was made.

  12. Role of Q-switched ND:YAG laser in nevus of Ota: A study of 25 cases

    Directory of Open Access Journals (Sweden)

    Shivangi Sharma

    2011-01-01

    Full Text Available Background: Nevus of Ota is common condition in Indian patients. The condition is more common in females, with a male-female ratio of 1:4.8. Aim : To evaluate long-term efficacy safety and stability of Q-switched ND:YAG laser in treatment of Nevus of Ota. Design: 6 month follow-up of patients of Nevus of Ota, treated with Q-switched ND:YAG laser Materials and Methods : Twenty-five patients of Nevus of Ota were treated with Q-switched ND:YAG laser for a period of 1 year and 9 months; patient had fitzpatricks skin type 4 and 5; detailed history, clinical examination, ophthalmoscopy, and otoscopy was done in all cases; clinical photographs were taken before and after the completion of treatments. Six-month follow-up was done after the last session. Response to treatment was graded based on physician′s global assessment. Result : More than 70% improvement was seen in 15 patients (60%. Eight patients (32% had moderate and two patients (8% showed mild improvement.

  13. ASSESSMENT OF QUALITY OF INNOVATIVE TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Larisa Alexejevna Ismagilova

    2016-12-01

    Full Text Available We consider the topical issue of implementation of innovative technologies in the aircraft engine building industry. In this industry, products with high reliability requirements are developed and mass-produced. These products combine the latest achievements of science and technology. To make a decision on implementation of innovative technologies, a comprehensive assessment is carried out. It affects the efficiency of the innovations realization. In connection with this, the assessment of quality of innovative technologies is a key aspect in the selection of technological processes for their implementation. Problems concerning assessment of the quality of new technologies and processes of production are considered in the suggested method with respect to new positions. The developed method of assessing the quality of innovative technologies stands out for formed system of the qualimetric characteristics ensuring the effectiveness, efficiency, adaptability of innovative technologies and processes. The feature of suggested system of assessment is that it is based on principles of matching and grouping of quality indicators of innovative technologies and the characteristics of technological processes. The indicators are assessed from the standpoint of feasibility, technologies competiveness and commercial demand of products. In this paper, we discuss the example of implementing the approach of assessing the quality of the innovative technology of high-tech products such as turbine aircraft engine.

  14. The additive influence of nevus flammeus and the nevus of Ota on congenital glaucoma

    Directory of Open Access Journals (Sweden)

    Sihota Ramanjit

    1991-01-01

    Full Text Available Nevus flammeus and nevus of Ota are commonly encountered dermatological conditions, but both individually, are only occasionally associated with glaucoma. The occurrence of isolated nevus flammeus along with nevus of Ota in the same patient is also extremely rare. We are presenting two unusual cases, both having a nevus of Ota, together with nevus flammeus and severe congenital glaucoma.

  15. Modelling in Medical Technology Assessment

    NARCIS (Netherlands)

    B.C. Michel (Bowine)

    1996-01-01

    textabstractHealth care is a rapidly developing field in which new technologies are introduced continuously. Not all new technologies have the same impact however: most represent only small changes in existing technologies, whereas only a few - like organ transplants - really are revolutionary new d

  16. Liquefaction technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-01

    A survey of coal liquefaction technology and analysis of projected relative performance of high potential candidates has been completed and the results are reported here. The key objectives of the study included preparation of a broad survey of the status of liquefaction processes under development, selection of a limited number of high potential process candidates for further study, and an analysis of the relative commercial potential of these candidates. Procedures which contributed to the achievement of the above key goals included definition of the characteristics and development status of known major liquefaction process candidates, development of standardized procedures for assessing technical, environmental, economic and product characteristics for the separate candidates, and development of procedures for selecting and comparing high potential processes. The comparisons were made for three production areas and four marketing areas of the US. In view of the broad scope of the objectives the survey was a limited effort. It used the experience gained during preparation of seven comprehensive conceptual designs/economic evaluations plus comprehensive reviews of the designs, construction and operation of several pilot plants. Results and conclusions must be viewed in the perspective of the information available, how this information was treated, and the full context of the economic comparison results. Comparative economics are presented as ratios; they are not intended to be predictors of absolute values. Because the true cost of constructing and operating large coal conversion facilities will be known only after commercialization, relative values are considered more appropriate. (LTN)

  17. Estimating Discrete Power Angular Spectra in Multiprobe OTA Setups

    DEFF Research Database (Denmark)

    Fan, Wei; Nielsen, Jesper Ødum; Pedersen, Gert Frølund

    2014-01-01

    The letter discusses over-the-air (OTA) testing for multiple-input–multiple-output (MIMO) capable terminals with emphasis on estimating discrete power angular spectrum modeled at the receiver (Rx) side in the test zone. Two techniques based on a uniform circular array (UCA) are proposed to obtain...

  18. Measurement Uncertainty Investigation in the Multi-probe OTA Setups

    DEFF Research Database (Denmark)

    Fan, Wei; Szini, Istvan Janos; Foegelle, M. D.

    2014-01-01

    Extensive efforts are underway to standardize over the air (OTA) testing of the multiple input multiple output (MIMO) capable terminals in COST IC1004, 3GPP RAN4 and CTIA. Due to the ability to reproduce realistic radio propagation environments inside the anechoic chamber and evaluate end user...

  19. Emulating Realistic Bidirectional Spatial Channels for MIMO OTA Testing

    DEFF Research Database (Denmark)

    Fan, Wei; Kyösti, Pekka; Nielsen, Jesper Ødum

    2015-01-01

    This paper discusses over the air (OTA) testing for multiple input multiple output (MIMO) capable terminals with emphasis on modeling bidirectional spatial channel models in multiprobe anechoic chamber (MPAC) setups. In the literature, work on this topic has been mainly focused on how to emulate ...

  20. Nevus of ota associated with nevus of Ito

    Directory of Open Access Journals (Sweden)

    Mukhopadhyay Amiya

    2004-03-01

    Full Text Available Nevus of Ota is a dermal melanocytic nevus seen predominantly in females. It is uncommon in India. Its association with nevus of Ito, another dermal melanocytic nevus, is extremely rare. We report this rare association in a male patient, which is another interesting feature of the present case.

  1. Bilateral nevus of ota with oral mucosal involvement

    Directory of Open Access Journals (Sweden)

    Rathi Sanjay

    2002-01-01

    Full Text Available A 30-year-old female presented with asymptomatic slate brown hyperpigmented diffuse macules on both the cheeks, nose, forehead, eyelids, sclera, conjunctiva and hard palate since early childhood. Nevus of Ota, are in Indian subcontinent, commonly occurs unilaterally on face. This case is being reported for its rarity and extensive involvement.

  2. 3D Channel Model Emulation in a MIMO OTA Setup

    DEFF Research Database (Denmark)

    Fan, Wei; Kyösti, Pekka; Sun, Fan

    2013-01-01

    This paper presents a new channel reconstruction technique for 3D geometry-based channels in a multi-probe based MIMO OTA setup. The proposed method provides a general channel reconstruction framework for any spherical power spectrum. The channel reconstruction is formed as convex optimization...

  3. Social Shaping in Danish Technology Assessment

    DEFF Research Database (Denmark)

    Hansen, Anne Grethe; Clausen, Christian

    2003-01-01

    for technology policy initiatives at the beginning of the new millennium, as prerequisites for socially feasible and desirable technology development and innovation. On the basis of the Danish technology assessments of the 1980s, it is argued that technology assessments and the social shaping perspectives...... in these projects contributed to new insights into the processes of technological change and thus to policy formulation. The social shaping perspective and technology assessment experiences are suggested as important guides to future technology strategies.......The term ‘social shaping of technology’ has been used broadly as a response to techno-economic deterministic understandings of the relations between technology and society. Social shaping has brought together analysts from different backgrounds who share a common interest in the role of social...

  4. Establishment of Health Technology Assessment in Iran

    Directory of Open Access Journals (Sweden)

    Shila Doaee

    2012-06-01

    Full Text Available Objective: Health Technology Assessment (HTA aims at informing healthcare policymakers, managers and practitioners of the "clinical consequences, but also the economic, ethical, and other social implications of the diffusion and use of a specific procedure or technique on medical practice". So considering the policy-oriented nature of HTA that calls for a close integration into the functioning and governance of health systems the present study focuses on executive processes and function of the HTA office of Iran.Materials and methods: Data of this review study were collected through documented sources and observations from 2007 to 2010.Results: Health Technology Assessment began its activities as a secretariat in the Deputy of Health in 2007 and it continues as a Health Technology Assessment Office at the Management of Health Technology Assessment, Standardization, and Tariff at the Deputy of curative affairs of MOHME in the beginning of 2010.14 Technology of modern medical equipment and 8 pharmaceutical medicine are assessed, Now many of measures for HTA establishment  such as cooperation National Institute of Health Research (NIHR, Holding scientific committee meetings, Establishing  the  Master's degree of  health technology assessment ,Building capacities for health technology assessment through education in major universities of the country.Conclusion: pay attention to health technology assessment, selection and application of proper technologies in the frameworks of policy-making and managerial strategies and make efforts to develop it with the support of the governmental in Iran is necessary.

  5. ASSESSMENT OF GALLIUM OXIDE TECHNOLOGY

    Science.gov (United States)

    2017-08-01

    Universe" ...................................... 5 Figure 4: MEA Architecture [60...weight. Figure 4: MEA Architecture [60] 2.2 How Does Ga2O3 Compare to Other Semiconductors? We are paying attention to β-Ga2O3 because of its...growth is possible. • Limited crystal orientation have been demonstrated. • Technology base is narrowly located in Japan . Mainstream technology

  6. Stability of ochratoxin A (OTA) during processing and decaffeination in commercial roasted coffee beans.

    Science.gov (United States)

    Nehad, E A; Farag, M M; Kawther, M S; Abdel-Samed, A K M; Naguib, K

    2005-08-01

    The fate of ochratoxin A (OTA) during the processing of artificially contaminated green coffee beans, the effect of decaffeination on the production of OTA in green and roasted coffee beans, and the effect of caffeine on the growth and OTA production by Aspergillus ochraceus were studied. The data indicated that the roasting, milling and decoction (brewing and Turkish coffee making) processes caused different percentage reductions in OTA. Decaffeinated samples showed a significantly higher concentration of OTA production than the caffeinated ones. A significantly higher percentage of OTA was reduced when the decaffeination process was performed before roasting treatment. Caffeine at 1.0 and 2.0% concentrations completely prevented OTA production and completely inhibited A. ochraceus growth in YES medium after 3-21 days.

  7. Technology for Online Portfolio Assessment Programs

    Science.gov (United States)

    Ferrara, Victoria M.

    2010-01-01

    Portfolio assessment is a valid and reliable method to assess experiential learning. Developing a fully online portfolio assessment program is neither easy nor inexpensive. The institution seeking to take its portfolio assessment program online must make a commitment to its students by offering the technologies most suited to meet students' needs.…

  8. Détermination du niveau de contamination de l'ochratoxine A (OTA dans les fèves de cacao à l'exportation

    Directory of Open Access Journals (Sweden)

    Silué, N.

    2009-01-01

    Full Text Available Determination of Ochratoxin A (OTA Levels in Exported Cocoa. This exported cocoa ochratoxin A contamination assessment target is to answer the legal dispositions and regulations. Three hundred (300 large samples of dried cocoa beans was taken according the Commission Regulation (EC No 401/2006 and OTA was quantified by HPLC analytical methods with extraction and clean-up on immunoaffinity columns. The global result shows that 33 samples out of 300 cocoa samples have levels of OTA above 2 μg/kg that constitutes 11.04% of total cocoa production in Ivory Coast. At the port of Abidjan rejected cocao beans were evaluated to 15.65%, if the maximum authorized levels are fixed to 2 μg/kg. The result for San Pedro port showed lower levels of OTA (only 6.67%. If we consider the Ivorian regulation that the under grade cocoa bean (S/G cannot been exported (the under grade cocoa bean (S/G is the dry cocoa bean of which the mould rate is above 4%, the slated cocoa bean rate is above 8% and the defective rate is also above 6%. At the both ports rejected cocoa beans constitutes 9.50% (11% at Abidjan and 8% at San Pedro. This cocoa beans contamination by OTA can be controlled or reduced by the efficient implementation and vulgarization of the good cocoa production, if we identify the critical points of contamination in the cocoa chain production by ochratoxigen fungi.

  9. ASSESSMENT OF QUALITY OF INNOVATIVE TECHNOLOGIES

    OpenAIRE

    Larisa Alexejevna Ismagilova; Nadegda Aleksandrovna Sukhova

    2016-01-01

    We consider the topical issue of implementation of innovative technologies in the aircraft engine building industry. In this industry, products with high reliability requirements are developed and mass-produced. These products combine the latest achievements of science and technology. To make a decision on implementation of innovative technologies, a comprehensive assessment is carried out. It affects the efficiency of the innovations realization. In connection with this, the assessment of qu...

  10. Life Cycle Assessment of Slurry Management Technologies

    DEFF Research Database (Denmark)

    Wesnæs, Marianne; Wenzel, Henrik; Petersen, Bjørn Molt

    This report contains the results of Life Cycle Assessments of two slurry management technologies - acidification and decentred incineration. The LCA foundation can be used by the contributing companies for evaluating the environmental sustainability of a specific technology from a holistic Life...... Cycle perspective. Through this the companies can evaluate the environmental benefits and disadvantages of introducing a specific technology for slurry management. From a societal perspective the results can contribute to a clarification of which slurry management technologies (or combination...

  11. Orbital malignant melanoma associated with nevus of Ota

    Directory of Open Access Journals (Sweden)

    Cherungottil V Radhadevi

    2013-01-01

    Full Text Available Nevus of Ota (oculodermal melanosis is a dermal melanocytic hamartoma with bluish hyperpigmentation along the first and second branches of the trigeminal nerve. Extracutaneous involvement, especially ocular, has been reported. A 45-year-old male presented with malignant melanoma of the left orbit in association with nevus of Ota. Being locally invasive, a modified exenteration with frontal flap repair was done on left eye. Adjuvant chemotherapy was given after wound healing. All pigmented lesions of the eye require close monitoring to help in the early diagnosis. Since malignant transformation has been reported in oculodermal melanosis, close follow-up and patient education will facilitate early diagnosis and prompt management. This case is reported for its rarity and unusual presentation.

  12. Orbital malignant melanoma associated with nevus of Ota.

    Science.gov (United States)

    Radhadevi, Cherungottil V; Charles, Kakkuzhiyil S; Lathika, Vasu K

    2013-06-01

    Nevus of Ota (oculodermal melanosis) is a dermal melanocytic hamartoma with bluish hyperpigmentation along the first and second branches of the trigeminal nerve. Extracutaneous involvement, especially ocular, has been reported. A 45-year-old male presented with malignant melanoma of the left orbit in association with nevus of Ota. Being locally invasive, a modified exenteration with frontal flap repair was done on left eye. Adjuvant chemotherapy was given after wound healing. All pigmented lesions of the eye require close monitoring to help in the early diagnosis. Since malignant transformation has been reported in oculodermal melanosis, close follow-up and patient education will facilitate early diagnosis and prompt management. This case is reported for its rarity and unusual presentation.

  13. Nevus of Ota: A series of 15 cases

    Directory of Open Access Journals (Sweden)

    Sekar Shanmuga

    2008-01-01

    Full Text Available Background: The nevus of Ota is a dermal nevus characterized by bluish pigmentation in the distribution of the first and the second division of the trigeminal nerve. Aim: Our aim was to study the cutaneous and extracutaneous manifestations of the nevus of Ota. Methods: A total of 15 cases were included in our study. A detailed history, clinical examination along with direct ophthalmoscopy and otoscopy were done for all the cases. Results: Most of the patients (60% had lesions at birth and the majority (86.7 % were females. Five (33.3% patients belonged to Tanino class II. Combined dermal and ocular involvement was observed in 60% of the cases. Conclusion: Tanino class II was the most common type observed in our studies. A few rarer associations such as nevus of Ito and hemangioma were also noted in our patients.

  14. Nevus of ota with buccal mucosal pigmentation: a rare case.

    Science.gov (United States)

    Shetty, Shishir Ram; Subhas, Babu G; Rao, Kumuda Arvind; Castellino, Renita

    2011-01-01

    Nevus of Ota is a condition wherein the typical pattern of the bluish black pigmentation is noticed along with the cutaneous distribution of the trigeminal nerve. This condition is most prevalent in Japanese population but comparatively rare among Indians. We report a case of 23-year-old female presented with unilateral pigmented areas over the skin of forehead, malar area, ear and periorbital area. Blackish-blue pigmented areas were also noticed on the sclera. Brownish-black diffuse pigmented areas were also noticed on the buccal mucosa of the same side. The presence of pigmentation on the skin over pinna and oral pigmentation made our case a rare incidence. Oral pigmentations associated with nevus of Ota especially on the buccal mucosa have rarely been reported in the past.

  15. Nevus of Ota with buccal mucosal pigmentation: A rare case

    Directory of Open Access Journals (Sweden)

    Shishir Ram Shetty

    2011-01-01

    Full Text Available Nevus of Ota is a condition wherein the typical pattern of the bluish black pigmentation is noticed along with the cutaneous distribution of the trigeminal nerve. This condition is most prevalent in Japanese population but comparatively rare among Indians. We report a case of 23-year-old female presented with unilateral pigmented areas over the skin of forehead, malar area, ear and periorbital area. Blackish-blue pigmented areas were also noticed on the sclera. Brownish-black diffuse pigmented areas were also noticed on the buccal mucosa of the same side. The presence of pigmentation on the skin over pinna and oral pigmentation made our case a rare incidence. Oral pigmentations associated with nevus of Ota especially on the buccal mucosa have rarely been reported in the past.

  16. Civil Engineering Technology Needs Assessment.

    Science.gov (United States)

    Oakland Community Coll., Farmington, MI. Office of Institutional Planning and Analysis.

    In 1991, a study was conducted by Oakland Community College (OCC) to evaluate the need for a proposed Civil Engineering Technology program. An initial examination of the literature focused on industry needs and the job market for civil engineering technicians. In order to gather information on local area employers' hiring practices and needs, a…

  17. Knowledge in health technology assessment

    DEFF Research Database (Denmark)

    Tjørnhøj-Thomsen, Tine; Hansen, Helle Ploug

    2011-01-01

    to generate knowledge and evidence about the patient aspects of a given technology. This raises questions about how knowledge is produced in HTA reports and what kind of knowledge is considered relevant. This article uses a Danish HTA on patient education from 2009 as empirical material for a critical...... examination and discussion of knowledge and knowledge production about the patient aspects of HTA....

  18. Wireless technology for ABC Assessment

    DEFF Research Database (Denmark)

    Kristensen, Margit; Kyng, Morten; Christensen, Erika Frischknecht;

      In medical emergency service (EMS) the ABC status (Airway-Breathing-Circulation) of victims is essential in the decision making process regarding prioritizing and treatment. Today's use of information technology does, however, not inform directly about "A" and "B". The parameters are evaluated ...

  19. Informe Final del Proyecto "Ordenamiento Territorial Ambientalmente Sustentable" (OTAS)

    OpenAIRE

    CONTRERAS-ALONSO, Miguel; OPAZO, Daniel; NÚÑEZ-PINO, Cecilia; Ubilla-Bravo, Gerardo

    2005-01-01

    El presente documento resume los principales resultados y propuestas surgidas en el marco del Proyecto Bases para el Ordenamiento Territorial Ambientalmente Sustentable de la Región Metropolitana de Santiago (Proyecto OTAS), el que ha sido una muy importante experiencia de estrecha cooperación entre el Gobierno Regional de la Región Metropolitana de Santiago (GORE RMS), la Agencia de Cooperación Técnica Alemana (GTZ) y la Universidad de Chile. El Proyecto OT...

  20. Intracranial meningeal melanocytoma associated with nevus of Ota.

    Science.gov (United States)

    Pan, Hao; Wang, Handong; Fan, Youwu

    2011-11-01

    We report a rare intracranial meningeal melanocytoma associated with the nevus of Ota. The patient was 36-year-old man with a 2-week history of headache and difficulty in opening his right eye. Physical examination showed a black nevus scattered on the right-hand side of the face, right eyelid ptosis and papilledema. CT scans and MRI showed a tumor in the region of the right cavernous sinus. The tumor was subtotally resected. Histological examination confirmed the diagnosis of melanocytoma.

  1. Technologies Assessing Limb Bradykinesia in Parkinson's Disease.

    Science.gov (United States)

    Hasan, Hasan; Athauda, Dilan S; Foltynie, Thomas; Noyce, Alastair J

    2017-01-01

    The MDS-UPDRS (Movement Disorders Society - Unified Parkinson's Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016. A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016. 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase. Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development.

  2. Benefits and harms of locking plate osteosynthesis in intraarticular (OTA Type C) fractures of the proximal humerus

    DEFF Research Database (Denmark)

    Brorson, Stig; Rasmussen, Jeppe Vejlgaard; Frich, Lars Henrik

    2012-01-01

    INTRODUCTION: Locking plate osteosynthesis of proximal humeral fractures are widely recommended and used, even in complex intraarticular fracture patterns such as AO/OTA Type C fractures. We systematically reviewed clinical studies assessing the benefits and harms of osteosynthesis with angle...... stable plates in AO/OTA Type C fractures of the proximal humerus. METHODS: We conducted an iterative search in PubMed, Embase, Cochrane Library, Web of Science, Cinahl, and PEDro in all languages from 1999 to November 2010. Eligible studies should study the outcome for Type C fractures after primary...... osteosynthesis with locking plate within two weeks of injury, and a follow-up period of six months or more. Patients should be evaluated with the Constant-Murley Score (CS). Two observers extracted data independently. RESULTS: Twelve studies and 282 Type C fractures were included. Results were categorised...

  3. Carbon Capture: A Technology Assessment

    Science.gov (United States)

    2013-10-21

    time. The absence of a significant market for the novel technologies put them at a further disadvantage . This is similar to the situation for CO2...the overall CCS process applied to a power plant or other industrial process. The CO2 produced from carbon in the fossil fuels or biomass feedstock...Air or Oxygen Fossil Fuels; Biomass USEFUL PRODUCTS (e.g., electricity, fuels, chemicals, hydrogen) CO2 CO2 Capture & Compress CO2 Transport CO2

  4. Assessing medical technologies in development; a new paradigm of medical technology assessment

    NARCIS (Netherlands)

    Hummel, J. Marjan; van Rossum, Wouter; Verkerke, Gijsbertus Jacob; Rakhorst, Gerhard

    2000-01-01

    Objective: Our study aims to provide a practical contribution to the field of medical technology assessment within a new paradigm. This paradigm indicates the need for more comprehensive technology assessments in the development stage of a new technology. - Method: We introduce a method, based on

  5. Assessing medical technologies in development - A new paradigm of medical technology assessment

    NARCIS (Netherlands)

    Hummel, MJM; van Rossum, W; Verkerke, GJ; Rakhorst, G

    2000-01-01

    Objective: Our study aims to provide a practical contribution to the field of medical technology assessment within a new paradigm. This paradigm indicates the need for more comprehensive technology assessments in the development stage of a new technology. Method: We introduce a method, based on Saat

  6. Automatization of Student Assessment Using Multimedia Technology.

    Science.gov (United States)

    Taniar, David; Rahayu, Wenny

    Most use of multimedia technology in teaching and learning to date has emphasized the teaching aspect only. An application of multimedia in examinations has been neglected. This paper addresses how multimedia technology can be applied to the automatization of assessment, by proposing a prototype of a multimedia question bank, which is able to…

  7. On Quality Assessment of Learning Technology Specifications

    NARCIS (Netherlands)

    Janssen, José; Berlanga, Adriana; Koper, Rob

    2012-01-01

    Janssen, J., Berlanga, A. J., & Koper, R. (2012). On Quality Assessment of Learning Technology Specifications. In J. C. Ramalho, A. Simões, & R. Queirós (Eds.). Innovations in XML Applications and Metadata Management: Advancing Technologies (pp. 78-95). Hershey, PA, USA: IGI Global. Below file

  8. A Suite of Tools for Technology Assessment

    Science.gov (United States)

    2007-09-01

    Saden, Povinelli & Rosen, 1989). • This was a significant change in emphasis on the part of NASA, where technology had previously viewed as merely...Cost Analysis Symposium, April 13, 2005. A Suite of Tools for Technology Assessment 24 Bibliography - continued: • Sadin, Stanley T.; Povinelli

  9. The internationalization of health technology assessment.

    Science.gov (United States)

    Menon, D; Marshall, D

    1996-01-01

    Health technology assessment as a formalized set of activities has a relatively short history. At its current stage of development, it is clear that it has global dimensions and impact. In this paper we review the history of health technology assessment, its development as a form of health services research, and its "institutionalization." We then identify the reasons for its internationalization, review current international initiatives, and propose actions to be taken to improve cooperation among countries.

  10. Health technology assessment. Evaluation of biomedical innovative technologies.

    Science.gov (United States)

    Turchetti, Giuseppe; Spadoni, Enza; Geisler, Eliezer Elie

    2010-01-01

    This article describes health technology assessment (HTA) as an evaluation tool that applies systematic methods of inquiry to the generation and use of health technologies and new products. The focus of this article is on the contributions of HTA to the management of the new product development effort in the biomedical organization. Critical success factors (CSFs) are listed, and their role in assessing success is defined and explained. One of the conclusions of this article is that HTA is a powerful tool for managers in the biomedical sector, allowing them to better manage their innovation effort in their continuing struggle for competitiveness and survival.

  11. Direct detection of OTA by impedimetric aptasensor based on modified polypyrrole-dendrimers

    Energy Technology Data Exchange (ETDEWEB)

    Mejri-Omrani, Nawel [ICMMO, CNRS, Université Paris-Saclay, Equipe de Chimie Bio-organique et Bio-inorganique, Bâtiment 420, 91405 Orsay (France); BAE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan (France); Université de Carthage, National Institute of Applied Sciences and Technology (INSAT) Laboratoire d' Ecologie et de Technologie Microbiennes (LETMi), 1080 Tunis (Tunisia); Miodek, Anna; Zribi, Becem [ICMMO, CNRS, Université Paris-Saclay, Equipe de Chimie Bio-organique et Bio-inorganique, Bâtiment 420, 91405 Orsay (France); Marrakchi, Mouna [Université de Carthage, National Institute of Applied Sciences and Technology (INSAT) Laboratoire d' Ecologie et de Technologie Microbiennes (LETMi), 1080 Tunis (Tunisia); Université de Tunis El Manar, Higher Institute of Applied Biological Sciences (ISSBAT), 1006 Tunis (Tunisia); Hamdi, Moktar [Université de Carthage, National Institute of Applied Sciences and Technology (INSAT) Laboratoire d' Ecologie et de Technologie Microbiennes (LETMi), 1080 Tunis (Tunisia); Marty, Jean-Louis [BAE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan (France); Korri-Youssoufi, Hafsa, E-mail: hafsa.korri-youssoufi@u-psud.fr [ICMMO, CNRS, Université Paris-Saclay, Equipe de Chimie Bio-organique et Bio-inorganique, Bâtiment 420, 91405 Orsay (France)

    2016-05-12

    Ochratoxin A (OTA) is a carcinogenic mycotoxin that contaminates food such as cereals, wine and beer; therefore it represents a risk for human health. Consequently, the allowed concentration of OTA in food is regulated by governmental organizations and its detection is of major agronomical interest. In the current study we report the development of an electrochemical aptasensor able to directly detect trace OTA without any amplification procedure. This aptasensor was constructed by coating the surface of a gold electrode with a film layer of modified polypyrrole (PPy), which was thereafter covalently bound to polyamidoamine dendrimers of the fourth generation (PAMAM G4). Finally, DNA aptamers that specifically binds OTA were covalently bound to the PAMAM G4 providing the aptasensor, which was characterized by using both Atomic Force Microscopy (AFM) and Surface Plasmon Resonance (SPR) techniques. The study of OTA detection by the constructed electrochemical aptasensor was performed using Electrochemical Impedance Spectroscopy (EIS) and revealed that the presence of OTA led to the modification of the electrical properties of the PPy layer. These modifications could be assigned to conformational changes in the folding of the aptamers upon specific binding of OTA. The aptasensor had a dynamic range of up to 5 μg L{sup −1} of OTA and a detection limit of 2 ng L{sup −1} of OTA, which is below the OTA concentration allowed in food by the European regulations. The efficient detection of OTA by this electrochemical aptasensor provides an unforeseen platform that could be used for the detection of various small molecules through specific aptamer association. - Highlights: • Development of innovative platform for direct and ultra-sensitive toxins detection. • Aptasensor based on modified conductive polypyrrole layer. • We demonstrate the conformation change of aptamer upon toxin binding. • We highlight that detection was obtained by modification of charge of

  12. The social function of technology assessment

    Science.gov (United States)

    Huddle, F. P.

    1972-01-01

    The problem of preserving the uneasy balance between a dynamic society and the equilibrium of man-environment society is discussed. Four sets of activities involved in technology assessment are considered: (1) Technology forecasting is necessary to warn of future dangers and opportunities, for effective timing, and to identify tradeoffs and alternatives. But forecasting is also chancy at best. (2) Social indicators need to be developed for the characterization of social status and measurement of social progress, as well as a better understanding of social needs. (3) With respect to technology assessment, the conflict between profitable directions of innovations and socially desirable directions is described, and a systematic way is needed to determine in advance what is technologically feasible to meet social needs. (4) National goals with respect to scientific and technological developments are also required.

  13. Too many cooks batter technology assessment.

    Science.gov (United States)

    Wagner, M

    1991-12-02

    The bustling activity and interest in technology assessment obscures two growing problems. More than 70 groups, sporting a variety of agendas, are involved in assessing new devices, drugs and procedures; variations in the information they seek or the methods they use sometimes produce findings that conflict or can't be compared.

  14. An environmental assessment system for environmental technologies

    DEFF Research Database (Denmark)

    Clavreul, Julie; Baumeister, Hubert; Christensen, Thomas Højlund

    2014-01-01

    A new model for the environmental assessment of environmental technologies, EASETECH, has been developed. The primary aim of EASETECH is to perform life-cycle assessment (LCA) of complex systems handling heterogeneous material flows. The objectives of this paper are to describe the EASETECH...

  15. An environmental assessment system for environmental technologies

    DEFF Research Database (Denmark)

    Clavreul, Julie; Baumeister, Hubert; Christensen, Thomas Højlund;

    2014-01-01

    A new model for the environmental assessment of environmental technologies, EASETECH, has been developed. The primary aim of EASETECH is to perform life-cycle assessment (LCA) of complex systems handling heterogeneous material flows. The objectives of this paper are to describe the EASETECH...

  16. Assessment and Learning Technologies: An Overview

    Science.gov (United States)

    Farrell, Treasa; Rushby, Nick

    2016-01-01

    Assessment pervades the learning process. This paper provides an overview of the application of technology to support and enhance diagnostic, formative and summative assessment. The focus is on examining how it can replace what already exists, improve the functionality, catalyse a redesign of the process and in some circumstances, make possible…

  17. Spent Nuclear Fuel Alternative Technology Risk Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Perella, V.F.

    1999-11-29

    A Research Reactor Spent Nuclear Fuel Task Team (RRTT) was chartered by the Department of Energy (DOE) Office of Spent Fuel Management with the responsibility to recommend a course of action leading to a final technology selection for the interim management and ultimate disposition of the foreign and domestic aluminum-based research reactor spent nuclear fuel (SNF) under DOE''s jurisdiction. The RRTT evaluated eleven potential SNF management technologies and recommended that two technologies, direct co-disposal and an isotopic dilution alternative, either press and dilute or melt and dilute, be developed in parallel. Based upon that recommendation, the Westinghouse Savannah River Company (WSRC) organized the SNF Alternative Technology Program to further develop the direct co-disposal and melt and dilute technologies and provide a WSRC recommendation to DOE for a preferred SNF alternative management technology. A technology risk assessment was conducted as a first step in this recommendation process to determine if either, or both, of the technologies posed significant risks that would make them unsuitable for further development. This report provides the results of that technology risk assessment.

  18. Nevus of ota with rare palatal involvement: a case report with emphasis on differential diagnosis.

    Science.gov (United States)

    Sharma, Gaurav; Nagpal, Archna

    2011-01-01

    Nevus of Ota, a dermal melanocytic nevus, is rare in the Indian subcontinent. It presents as a brown, blue, or gray patch on the face and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The oral cavity is infrequently involved in nevus of Ota. Only 11 cases have been documented in the English literature. We report a rare case of intraoral nevus of Ota in a 22-year-old male patient. This paper focuses on the differential diagnosis of oral manifestations of nevus of Ota to assist in proper followup to avert malignant transformation.

  19. Nevus of Ota with Rare Palatal Involvement: A Case Report with Emphasis on Differential Diagnosis

    Directory of Open Access Journals (Sweden)

    Gaurav Sharma

    2011-01-01

    Full Text Available Nevus of Ota, a dermal melanocytic nevus, is rare in the Indian subcontinent. It presents as a brown, blue, or gray patch on the face and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The oral cavity is infrequently involved in nevus of Ota. Only 11 cases have been documented in the English literature. We report a rare case of intraoral nevus of Ota in a 22-year-old male patient. This paper focuses on the differential diagnosis of oral manifestations of nevus of Ota to assist in proper followup to avert malignant transformation.

  20. Health technology assessment and thyroid surgery.

    Science.gov (United States)

    Lucchini, R; Sanguinetti, A; Monacelli, M; Triola, R; Avenia, S; Conti, C; Santoprete, S; Avenia, N

    2013-01-01

    The growth of technological innovation, the request for assistance, the rising patient's expectations and the interest of the industry have led to a rise in the cost of health care systems. In this context the role of the National Health System is not to delay the development or adoption of new technologies, but rather to drive the development selecting priorities and promoting its use. Health Technology Assessment (HTA) is a multidisciplinary and multidimensional approach for analyzing the medical-clinical, social, organizational, economic, ethical and legal implications of a technology (devices, drugs, procedures) through the assessment of multiple parameters such as effectiveness, safety, costs of the social and organizational impact. A health technology assessment is a comprehensive, systematic evaluation of the prerequisites for estimating the consequences of using health technology. Main characteristic of HTA is that the problem is tackled using an approach focused on four main elements: - technology; - patient; - organization; - economy. The authors have applied the HTA method for the analysis of the ultrasonic focus dissector on thyroid surgery. They compared the cost of the surgical procedure using the ultrasonic dissector and without it in a case study of 440 patients who underwent thyroidectomy.

  1. Health Technology Assessment and patient safety

    Directory of Open Access Journals (Sweden)

    Andrew Mulcahy

    2005-12-01

    Full Text Available

    Health Technology Assessment (HTA is a process used to evaluate the clinical effectiveness and costeffectiveness of health technologies by a systematic review of clinical, economic, and utilization research.

    Despite widespread investment in patient safety technologies in the U.K., U.S., and elsewhere, little HTA has been done to establish the clinical or cost-effectiveness of these technologies. The HTA and patient safety literature suggests there are four categories of patient safety HTA, including HTA for existing safety technologies, underutilized safety technologies, emerging safety technologies, as well as safety aspects of technologies with a non-safety primary purpose.

    Recent HTA and other research, including a 2002 evidencebased evaluation of patient safety technologies from the U.S. Agency for Health Research and Quality, provide an important foundation for a more comprehensive approach to patient safety HTA. However, HTA programs must address prioritization, methodology, and dissemination challenges introduced by patient safety technologies before significant progress can Te made.

  2. Resumen Ejecutivo del Proyecto "Ordenamiento Territorial Ambientalmente Sustentable" (OTAS)

    OpenAIRE

    CONTRERAS-ALONSO, Miguel; Ubilla-Bravo, Gerardo

    2005-01-01

    El presente informe es el resumen de los principales resultados y propuestas surgidas en el marco del Proyecto Bases para el Ordenamiento Territorial Ambientalmente Sustentable de la Región Metropolitana de Santiago (Proyecto OTAS), el que ha sido una muy importante experiencia de estrecha cooperación entre el Gobierno Regional de la Región Metropolitana de Santiago (GORE RMS), la Agencia de Cooperación Técnica Alemana (GTZ) y la Universidad de Chile. El Pro...

  3. Independent Assessment of Technology Characterizations to Support the Biomass Program Annual State-of-Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, B.

    2011-03-01

    This report discusses an investigation that addressed two thermochemical conversion pathways for the production of liquid fuels and addressed the steps to the process, the technology providers, a method for determining the state of technology and a tool to continuously assess the state of technology. This report summarizes the findings of the investigation as well as recommendations for improvements for future studies.

  4. Status and assessment of photovoltaic technologies

    Science.gov (United States)

    Kazmerski, L. L.

    The history and status of the current photovoltaic technologies are reviewed and evaluated. The problems and strengths of single-crystal, polycrystalline, and amorphous technologies are discussed, compared, and assessed. Single-junction and multiple-junction or tandem cell configurations are evaluated for performance, processing, and engineering criteria. Some emphasis is placed on the emerging thin film options for low cost terrestrial applications. The basic photovoltaic system building block, the solar cell, is discussed along with important module developments and problems. Future technology and research directions are provided for materials, cells, and modules.

  5. Status and assessment of photovoltaic technologies

    Energy Technology Data Exchange (ETDEWEB)

    Kazmerski, L.L. (Solar Energy Research Inst., Golden, CO (USA))

    1989-01-01

    The history and status of the current photovoltaic technologies are reviewed and evaluated. The problems and strengths of single-crystal, polycrystalline, and amorphous technologies are discussed, compared and assessed. Single-junction and multiple-junction or tandem cell configurations are evaluated for performance, processing, and engineering criteria. Some emphasis is placed on the emerging thin film options for low cost terrestrial applications. Discussions centre around the basic photovoltaic system building block, the solar cell, but important module developments and problems are cited. Future technology and research directions are provided for materials, cells, and modules. (author).

  6. Evidence review of technology and dietary assessment.

    Science.gov (United States)

    Long, JoAnn D; Littlefield, Laurel A; Estep, Gary; Martin, Hope; Rogers, Toby J; Boswell, Carol; Shriver, Brent J; Roman-Shriver, Carmen R

    2010-12-01

    Diets high in fruit and vegetable consumption are associated with a decrease in chronic diseases. Dietary factors are linked to 4 of the 10 leading noncommunicable causes of death: cardiovascular disease, some cancers, stroke, and type 2 diabetes. Accurately measuring dietary patterns has many challenges. Dietary intake measurement has traditionally relied on self-report instruments such as 24-hour recall, food record, and food frequency questionnaires to record consumption history. These methods have inherent limitations in detecting small but important changes in fruit and vegetable consumption patterns. Promising advances in technology have made more sophisticated techniques for recording dietary intake possible. Computers and Web-based programs, handheld personal digital assistants with cameras and telephone cards, smart phones, cameras, and video recorders options may reduce the burden of recording what has been consumed. Furthermore, technology-based methods of dietary assessment may provide a higher degree of reliability and validity in visually determining fruit and vegetable consumption, and additional study is warranted. The purpose of this article is to present a review of the evidence on the effectiveness of technology-based methods for dietary assessment, which included fruit and vegetable consumption. One hundred and eighty-seven articles published between 1998 and 2008 were initially identified. Fifteen met the study inclusion criteria and were evaluated by an interdisciplinary team using the Stetler Strength of Evidence Scale. Six technology-based methods for dietary assessment were identified. Findings from validity and reliability testing of technology-based methods are encouraging and need replication. Clinically important features offered through technology may reduce reporting burden and offer behavioral feedback to users. Methodologically sound, empirical research into using technology-based application for dietary assessment in a variety of

  7. A Health Technology Assessment: laparoscopy versus colpoceliotomy.

    Science.gov (United States)

    Damonti, A; Ferrario, L; Morelli, P; Mussi, M; Patregnani, C; Garagiola, E; Foglia, E; Pagani, R; Carminati, R; Porazzi, E

    2015-01-01

    The objective of this paper is the comparison between two different technologies used for the removal of a uterine myoma, a frequent benign tumor: the standard technology currently used, laparoscopy, and an innovative one, colpoceliotomy. It was considered relevant to evaluate the real and the potential effects of the two technologies implementation and, in addition, the consequences that the introduction or exclusion of the innovative technology would have for both the National Health System (NHS) and the entire community. The comparison between these two different technologies, the standard and the innovative one, was conducted using a Health Technology Assessment (HTA). In particular, in order to analyse their differences, a multi-dimensional approach was considered: effectiveness, costs and budget impact analysis data were collected, applying different instruments, such as the Activity Based Costing methodology (ABC), the Cost-Effectiveness Analysis (CEA) and the Budget Impact Analysis (BIA). Organisational, equity and social impact were also evaluated. The results showed that the introduction of colpoceliotomy would provide significant economic savings to the Regional and National Health Service; in particular, a saving of € 453.27 for each surgical procedure. The introduction of the innovative technology, colpoceliotomy, could be considered a valuable tool; one offering many advantages related to less invasiveness and a shorter surgical procedure than the standard technology currently used (laparoscopy).

  8. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik

    2007-01-01

    As a consequence of the EU Water Framwork Directive, more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advenced treatment technologies. This paper describes a holistic assessment...... of sustainability, sand filtration is the most advantageous method based on the technical and environmental assessment due to the low energy consumption and high efficiency with regard to the removal of heavy metals....

  9. Meningeal melanocytoma of Meckel's cave associated with ipsilateral Ota's nevus.

    Science.gov (United States)

    Botticelli, A R; Villani, M; Angiari, P; Peserico, L

    1983-06-15

    A case of meningeal melanocytoma of the left Meckel's cave associated with ipsilateral Ota's nevus in a 43-year-old woman, was studied by light and electron microscopy. The cells of the tumor were characterized by the presence of dendritic cytoplasmic processes, melanosomes and premelanosomes; hence, they were deemed as neoplastic melanocytes. Moreover, the tumor was lacking in histologic and ultrastructural features of pigmented meningioma, melanotic Schwannoma and primary meningeal melanoma. The prolonged clinical course was different from primary and metastatic malignant melanomas of the meninges. The best treatment appears to be radical excision, when possible; otherwise, the local or partial enucleation followed by radiation therapy has been found to be the best curative to date. On the whole, meningeal melanocytoma cannot be considered as entirely benign, given its morphologic patterns that resemble those of uveal melanoma, and its potential for recurrence. The association of this tumor with Ota's nevus is referred to as having a common origin from an arrested migration of melanoblasts at different stages.

  10. Pigment reduction in nevus of Ota following leech therapy

    Science.gov (United States)

    Rastogi, Sanjeev; Chaudhari, Priyanka

    2014-01-01

    Nevus of Ota is a congenital blue-gray color nevus afflicting unilaterally, the area near the eyes. It poses a huge cosmetic concern besides being a potential threat for developing melanoma sometime in the course of the disease. The treatment options are neither many nor promising besides they are too expensive. We have treated a case of nevus of Ota with leech therapy where leech was applied upon the lesion for five times spanned in a period of 2 months. The results in terms of change in the color of lesion were evaluated with the help of serial photographs following every treatment session to mark the level of color changes in the lesion. A substantial reduction in color of the nevus was reported following the completion of the therapy. The results were demonstrated with the photographs. Although, recommended as the classical Ayurvedic management for skin diseases, leech therapy is not reported earlier in such conditions. It proposes a novel approach to deal with such congenital pigment lesions where other options are not promising. PMID:24948864

  11. Pigment reduction in nevus of Ota following leech therapy

    Directory of Open Access Journals (Sweden)

    Sanjeev Rastogi

    2014-01-01

    Full Text Available Nevus of Ota is a congenital blue-gray color nevus afflicting unilaterally, the area near the eyes. It poses a huge cosmetic concern besides being a potential threat for developing melanoma sometime in the course of the disease. The treatment options are neither many nor promising besides they are too expensive. We have treated a case of nevus of Ota with leech therapy where leech was applied upon the lesion for five times spanned in a period of 2 months. The results in terms of change in the color of lesion were evaluated with the help of serial photographs following every treatment session to mark the level of color changes in the lesion. A substantial reduction in color of the nevus was reported following the completion of the therapy. The results were demonstrated with the photographs. Although, recommended as the classical Ayurvedic management for skin diseases, leech therapy is not reported earlier in such conditions. It proposes a novel approach to deal with such congenital pigment lesions where other options are not promising.

  12. Pigment reduction in nevus of Ota following leech therapy.

    Science.gov (United States)

    Rastogi, Sanjeev; Chaudhari, Priyanka

    2014-04-01

    Nevus of Ota is a congenital blue-gray color nevus afflicting unilaterally, the area near the eyes. It poses a huge cosmetic concern besides being a potential threat for developing melanoma sometime in the course of the disease. The treatment options are neither many nor promising besides they are too expensive. We have treated a case of nevus of Ota with leech therapy where leech was applied upon the lesion for five times spanned in a period of 2 months. The results in terms of change in the color of lesion were evaluated with the help of serial photographs following every treatment session to mark the level of color changes in the lesion. A substantial reduction in color of the nevus was reported following the completion of the therapy. The results were demonstrated with the photographs. Although, recommended as the classical Ayurvedic management for skin diseases, leech therapy is not reported earlier in such conditions. It proposes a novel approach to deal with such congenital pigment lesions where other options are not promising.

  13. Test Setup for Anechoic Room based MIMO OTA Testing of LTE Terminals

    DEFF Research Database (Denmark)

    Carreño, Xavier; Fan, Wei; Nielsen, Jesper Ødum;

    2013-01-01

    introduced into, for example, LTE andWiMAX systems. The main purpose of this testing is to validate that the user equipment will have a good performance in real use. CTIA, 3GPP and COST are spending a big effort in standardizing the OTA testing procedure which is much more complex than similar SISO OTA...

  14. Analyzing Reasons for Non-Adoption of Distance Delivery Formats in Occupational Therapy Assistant (OTA) Education

    Science.gov (United States)

    Gergen, Theresa; Roblyer, M. D.

    2013-01-01

    Though distance education formats could help address an urgent need for growth in the occupational therapy assistant (OTA) workforce, distance methods are not as accepted in these programs as they are in other professional and clinical programs. This study investigated whether beliefs and levels of experience of OTA program directors shaped their…

  15. Detection of ochratoxin A (OTA) in coffee using chemiluminescence resonance energy transfer (CRET) aptasensor.

    Science.gov (United States)

    Jo, Eun-Jung; Mun, Hyoyoung; Kim, Su-Ji; Shim, Won-Bo; Kim, Min-Gon

    2016-03-01

    We report a chemiluminescence resonance energy transfer (CRET) aptasensor for the detection of ochratoxin A (OTA) in roasted coffee beans. The aptamer sequences used in this study are 5'-DNAzyme-Linker-OTA aptamer-3'-dabcyl. Dabcyl at the end of the OTA aptamer region plays as a quencher in CRET aptasensor. When hemin and OTA are added, the dabcyl-labeled OTA aptamer approaches to the G-quadruplex-hemin complex by formation of the G-quadruplex-OTA complex. The G-quadruplex-hemin complexes possess horseradish peroxidase (HRP)-like activity, and therefore, the HRP-mimicking DNAzyme (HRPzyme) catalyzes peroxidation in the presence of luminol and H2O2. Resonance energy transfer between luminol (donor) and dabcyl (acceptor) enables quenching of chemiluminescence signals. The signal decreases with increasing the concentration of OTA within the range of 0.1-100ngmL(-1) (limit of detection 0.22ngmL(-1)), and the level of recovery of the respective 1ngmL(-1) and 10ngmL(-1) spiked coffee samples was 71.5% and 93.3%. These results demonstrated the potential of the proposed method for OTA analysis in diverse foods.

  16. Analyzing Reasons for Non-Adoption of Distance Delivery Formats in Occupational Therapy Assistant (OTA) Education

    Science.gov (United States)

    Gergen, Theresa; Roblyer, M. D.

    2013-01-01

    Though distance education formats could help address an urgent need for growth in the occupational therapy assistant (OTA) workforce, distance methods are not as accepted in these programs as they are in other professional and clinical programs. This study investigated whether beliefs and levels of experience of OTA program directors shaped their…

  17. Broadband Satellite Technologies and Markets Assessed

    Science.gov (United States)

    Wallett, Thomas M.

    1999-01-01

    The current usage of broadband (data rate greater than 64 kilobits per second (kbs)) for multimedia network computer applications is increasing, and the need for network communications technologies and systems to support this use is also growing. Satellite technology will likely be an important part of the National Information Infrastructure (NII) and the Global Information Infrastructure (GII) in the next decade. Several candidate communications technologies that may be used to carry a portion of the increased data traffic have been reviewed, and estimates of the future demand for satellite capacity have been made. A study was conducted by the NASA Lewis Research Center to assess the satellite addressable markets for broadband applications. This study effort included four specific milestones: (1) assess the changing nature of broadband applications and their usage, (2) assess broadband satellite and terrestrial technologies, (3) estimate the size of the global satellite addressable market from 2000 to 2010, and (4) identify how the impact of future technology developments could increase the utility of satellite-based transport to serve this market.

  18. Interactive Technology Assessment in the Real World

    NARCIS (Netherlands)

    Marris, Claire; Joly, Pierre-Benoit; Rip, Arie

    2008-01-01

    Participatory Technology Assessment (pTA) initiatives have usually been analyzed as if they existed in a social and political vacuum. This article analyzes the linkages that occur, in both directions, between the microcosm set up by a pTA exercise and the real world outside. This dual-dynamics persp

  19. Community Needs Assessment Office Administration & Technology (OAT).

    Science.gov (United States)

    Pezzoli, J. A.; Lum, Ku'uipo; Meyer, Diane

    The purpose of this survey was to obtain from employers the requisite skills and potential employment demand for office workers on Maui. Of particular interest was: (1) the assessment of various clerical skills and computer software in its relevance to the Office Administration & Technology (OAT) curriculum at Maui Community College; and (2)…

  20. Teacher Learning of Technology Enhanced Formative Assessment

    Science.gov (United States)

    Feldman, Allan; Capobianco, Brenda M.

    2008-01-01

    This study examined the integration of technology enhanced formative assessment (FA) into teachers' practice. Participants were high school physics teachers interested in improving their use of a classroom response system (CRS) to promote FA. Data were collected using interviews, direct classroom observations, and collaborative discussions. The…

  1. Interactive technology assessment and wide reflective equilibrium.

    NARCIS (Netherlands)

    Reuzel, R.P.B.; Wilt, G.J. van der; Have, H.A.M.J. ten; Vries Robbé, P.F. de

    2001-01-01

    Interactive technology assessment (iTA) provides an answer to the ethical problem of normative bias in evaluation research. This normative bias develops when relevant perspectives on the evaluand (the thing being evaluated) are neglected. In iTA this bias is overcome by incorporating different persp

  2. An assessment of information communication technology content ...

    African Journals Online (AJOL)

    An assessment of information communication technology content, context and process dimensions in public health facilities in Machakos and Nairobi ... to lack of support from hospital top management team (χ 9.44, d.f.=4 and p=0.005).

  3. Technology and the issues facing nursing assessment.

    Science.gov (United States)

    Ansell, Helen; Meyer, Alannah; Thompson, Shona

    This article describes an investigation into the use of technology and the issues nurses face undertaking nursing assessment. It reports qualitative, descriptive research involving interviews with ten ward nurses from three hospitals in New Zealand. Thematic analysis of the data revealed three key issues: the impact of technology, the influence of early warning systems and nurse autonomy. Results show how clinical decision making around nursing assessment is influenced by technology and the Early Warning Score. These clinical decisions may not always be informed by critical thinking in complex healthcare environments. The article concludes that nurse autonomy, while supported and endorsed in theory, is frequently in conflict with hospital risk-management policies and the use of prescriptive algorithms.

  4. Biomass Gasification Technology Assessment: Consolidated Report

    Energy Technology Data Exchange (ETDEWEB)

    Worley, M.; Yale, J.

    2012-11-01

    Harris Group Inc. (HGI) was commissioned by the National Renewable Energy Laboratory to assess gasification and tar reforming technologies. Specifically, the assessments focused on gasification and tar reforming technologies that are capable of producing a syngas suitable for further treatment and conversion to liquid fuels. HGI gathered sufficient information to analyze three gasification and tar reforming systems. This report summarizes the equipment, general arrangement of the equipment, operating characteristics, and operating severity for each technology. The order of magnitude capital cost estimates are supported by a basis-of-estimate write-up, which is also included in this report. The report also includes Microsoft Excel workbook models, which can be used to design and price the systems. The models can be used to analyze various operating capacities and pressures. Each model produces a material balance, equipment list, capital cost estimate, equipment drawings and preliminary general arrangement drawings. Example outputs of each model are included in the Appendices.

  5. Impact of Probe Placement Error on MIMO OTA Test Zone Performance

    DEFF Research Database (Denmark)

    Fan, Wei; Nielsen, Jesper Ødum; Carreño, Xavier;

    2012-01-01

    Standardization work for MIMO OTA testing methods is currently ongoing, where a multi-probe anechoic chamber based solution is an important candidate. In this paper, the probes located on an OTA ring are used to synthesize a plane wave field in the center of the OTA ring, and the EM field for each...... probe is obtained using FDTD simulation. This paper investigates the extent to which we can control the field structure inside the test zone where the device under test is located. The focus is on performance deterioration introduced by probe placement error including OTA probe orientation error...... and location mismatch, which are general non-idealities in practical MIMO OTA test systems....

  6. Assessment of Sensor Technologies for Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Korsah, Kofi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vlim, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Britton, Jr, Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wootan, D. W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anheier, Jr, N. C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Diaz, A. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, E. H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chien, H. T. [Argonne National Lab. (ANL), Argonne, IL (United States); Sheen, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Bakhtiari, Sasan [Argonne National Lab. (ANL), Argonne, IL (United States); Gopalsami, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Heifetz, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Tam, S. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Park, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Upadhyaya, B. R. [Univ. of Tennessee, Knoxville, TN (United States); Stanford, A. [Univ. of Tennessee, Knoxville, TN (United States)

    2016-10-01

    Sensors and measurement technologies provide information on processes, support operations and provide indications of component health. They are therefore crucial to plant operations and to commercialization of advanced reactors (AdvRx). This report, developed by a three-laboratory team consisting of Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL), provides an assessment of sensor technologies and a determination of measurement needs for AdvRx. It provides the technical basis for identifying and prioritizing research targets within the instrumentation and control (I&C) Technology Area under the Department of Energy’s (DOE’s) Advanced Reactor Technology (ART) program and contributes to the design and implementation of AdvRx concepts.

  7. Constructive Technology Assessment for HIT development

    DEFF Research Database (Denmark)

    Høstgaard, Anna Marie Balling; Bertelsen, Pernille; Petersen, Lone Stub

    2013-01-01

    Experience and time has shown a need for new evaluation methods for evaluating Health Information Technology (HIT), as summative evaluation methods fail to accommodate the rapid and constant changes in HIT over time and to involve end-users, which has been recognized as an important success factor...... in HIT development. A new evaluation methodology, including an analytical framework, has been developed specifically for HIT development: Constructive Technology Assessment (CTA) for HIT. It offers solutions to both the problems associated with summative technology evaluation and a way to involve end......-users. The CTA methodology is based on a Socio-technical understanding of technological development as an open ended, emergent process. The CTA was used during the EHR development process in the Region of North Jutland where it proved successful inproviding learning and feedback between all relevant groups...

  8. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik

    2007-01-01

    , which includes technical, economic and environmental aspects. The technical and economic assessment is performed on 5 advanced treatment technologies: sand filtration, ozone treatment, UV exclusively for disinfection of pathogenic microorganisms, Membrane Bioreactor (MBR), and UV in combination...... and three advanced treatment methods: sand filtration, ozone treatment and MBR. The technical and economic assessment showed that UV solely for disinfection purposes or ozone treatment are the most advantageous advanved treatment methods if the demands are restricted to pathogenic microorganisms. In terms......As a consequence of the EU Water Framwork Directive, more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advenced treatment technologies. This paper describes a holistic assessment...

  9. Sustainability assessment of advanced wastewater treatment technologies.

    Science.gov (United States)

    Høibye, L; Clauson-Kaas, J; Wenzel, H; Larsen, H F; Jacobsen, B N; Dalgaard, O

    2008-01-01

    As a consequence of the EU Water Framework Directive more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advanced treatment technologies. This paper describes a holistic assessment, which includes technical, economical and environmental aspects. The technical and economical assessment is performed on 5 advanced treatment technologies: sand filtration, ozone treatment, UV exclusively for disinfection of pathogenic microorganisms, membrane bioreactor (MBR) and UV in combination with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances and three advanced treatment methods; sand filtration, ozone treatment and MBR. The technical and economic assessment showed that UV solely for disinfection purposes or ozone treatment is the most advantageous advanced treatment methods if the demands are restricted to pathogenic microorganisms. In terms of sustainability, sand filtration is the most advantageous method based on the technical and environmental assessment due to the low energy consumption and high efficiency with regards to removal of heavy metals.

  10. Technology enhanced peer learning and peer assessment

    DEFF Research Database (Denmark)

    Henriksen, Christian Bugge; Bregnhøj, Henrik; Rosthøj, Susanne

    2016-01-01

    This paper explores the application of learning designs featuring formalised and structured technology enhanced peer learning. These include student produced learning elements, peer review discussions and peer assessment in the BSc/MSc level summer course Restoration of European Ecosystems...... and Freshwaters (REEF), the Master thesis preparation seminars for the Master of Public Health (MPH) and the MOOC course Global Environmental Management (GEM). The application of student produced learning elements and peer review discussions is investigated by analyzing quotes from course evaluations...... and performing focus group interviews. The application of peer assessment is investigated by analyzing the agreement of peer assessment between students assessing the same assignment. Our analyses confirm previous research on the value of peer learning and peer assessment and we argue that there could also...

  11. Technology enhanced peer learning and peer assessment

    Directory of Open Access Journals (Sweden)

    Christian Bugge Henriksen

    2016-11-01

    Full Text Available This paper explores the application of learning designs featuring formalised and structured technology enhanced peer learning. These include student produced learning elements, peer review discussions and peer assessment in the BSc/MSc level summer course Restoration of European Ecosystems and Freshwaters (REEF, the Master thesis preparation seminars for the Master of Public Health (MPH and the MOOC course Global Environmental Management (GEM. The application of student produced learning elements and peer review discussions is investigated by analyzing quotes from course evaluations and performing focus group interviews. The application of peer assessment is investigated by analyzing the agreement of peer assessment between students assessing the same assignment. Our analyses confirm previous research on the value of peer learning and peer assessment and we argue that there could also be a huge benefit from developing learning design patterns that facilitate informal peer learning and reinforce knowledge sharing practices.

  12. Health Technology Assessment: a field still maturing!

    Directory of Open Access Journals (Sweden)

    Renaldo N. Battista

    2005-06-01

    Full Text Available

    With this issue’s focus on Health Technology Assessment (HTA, the Italian Journal of Public Health has tackled an area of growing importance in today’s increasingly complex health care delivery systems.

    As the articles in this issue demonstrate, HTA has grown from a relatively narrow technical focus to a form of policy research underway in dozens of countries. Since its inception just over three decades ago,HTA has evolved through three distinct phases: the machine, the disease and the delivery mode, with the third of these still underway.

    As the focus has shifted from machines to disease conditions to service delivery approaches, HTA has drawn on research and modes of discourse from a growing variety of disciplines. Thus, despite the evolution that continues, HTA remains, at its core, both multidisciplinary and pragmatic, for the strengths of HTA arise from its integration of the efforts of actors in multiple, diverse disciplines with a view to producing knowledge that will assist decision-makers. The machine phase was marked by a focus on the technical performance of health technologies, often embodying innovative approaches to diagnosis or treatment of human illness.

    Given the newness and costliness of many technologies selected for assessment, a significant emphasis was placed on assessing the safety of these devices. Imaging technologies were the subject of assessment in many settings, perhaps in part because devices such as the CT scanner produced remarkable visual results that were heralded as affording breakthroughs in diagnosis and treatment. One need only look through the programs of early HTA conferences to see the emphasis on high cost, infrastructure-intensive health technologies that was the hallmark of the machine period.

  13. Technology Audit: Assessment of Innovative Portfolio

    Directory of Open Access Journals (Sweden)

    Kurushina Viktoria

    2016-01-01

    Full Text Available The article discusses the features of the technological audit performing in the companies of oil and gas sector of Russian economy. To measure the innovations quality level the scale was developed based on the Theory of Inventive Problem Solving and the theory of technological structures. Figures of the innovations quantity by levels, volume and quality of the innovative portfolio are offered for assessment the innovative portfolio quality. The method was tested on an example of oil and gas transporting enterprises. The results of the comparative analysis of innovative portfolio are shown.

  14. In vivo and ex vivo phagocytic potential of macrophages from progeny of breeder hens kept on ochratoxin A (OTA)-contaminated diet.

    Science.gov (United States)

    Zahoor-ul-Hassan; Khan, Muhammad Zargham; Khan, Ahrar; Javed, Ijaz; Noreen, Mnaza

    2012-01-01

    This study aimed to investigate the phagocytic potential of macrophages in progeny of breeder hens kept on an OTA-contaminated diet. For this purpose, 84 White Leghorn (WL) layer breeder hens (40-weeks-of-age) were divided into seven groups (A-G). Hens in Group A were fed a commercial layer ration while those in Groups B-G were kept on a diet amended with 0.1, 0.5, 1.0, 3.0, 5.0, or 10.0 mg OTA/kg, respectively, for up to 3 weeks (n = 12/treatment group; n = 4/time sub-group/treatment group). Fertile eggs were set for hatching on a weekly basis to get the progeny of each week separately. Hatched chicks (n = 10 from each group) were injected with India ink at day 14-of-age to study the in vivo phagocytosis of carbon particles. At day 30, abdominal macrophages were collected from 15 chicks/group and were used to assess their ex vivo/in vitro phagocytic potential against sheep red blood cells (SRBC) as well as for nitrite production upon challenge with lipopolysaccharide (LPS). The phagocytic indices of the reticuloendothelial system of all three sets of progeny (chicks obtained from hens fed OTA for 7, 14, and 21 days) were significantly lower than values seen with Group A chicks. The number of macrophages that were actively phagocytic, the number of SRBC internalized per macrophage, and the extent of nitrite production after stimulation with LPS were each significantly lower in the cells obtained from chicks of breeder hens that had been maintained on the OTA-contaminated diets. The findings of this study clearly showed that there are immunosuppressive effects-in terms of depressed in vivo and in vitro macrophage functionality-in progeny of OTA-fed breeder hens.

  15. PROFESSOR DR. ION PIŞOTA (1925 – 2008

    Directory of Open Access Journals (Sweden)

    Liliana ZAHARIA

    2009-12-01

    Full Text Available Professor Ion Pişota was born on June 6, 1925, in Hrupiştea, a small settlement in Greek Macedonia, from where he and his family came to Romania in 1927, where he got Romanian citizenship. Between 1941 and 1945, he attended the Tulcea Boys High School and later on, in 1947 he entered the Faculty of Geology – Geography at the University of Bucharest, where he continued to excel until 1951, when he graduated. In the fall of 1950, he took up a tutor position in the field of Hydrolgy at the same faculty passing subsequently through all the stages of academic hierarchy until he became, in 1971, a University Professor. Even after he retired, in 1996, he continued his academic activity as a consultant professor within the same department and faculty that he served with passion and devotion for more than 50 years.

  16. Natural-technological risk assessment and management

    Science.gov (United States)

    Burova, Valentina; Frolova, Nina

    2016-04-01

    EM-DAT statistical data on human impact and economic damages in the 1st semester 2015 are the highest since 2011: 41% of disasters were floods, responsible for 39% of economic damage and 7% of events were earthquakes responsible for 59% of total death toll. This suggests that disaster risk assessment and management still need to be improved and stay the principle issue in national and international related programs. The paper investigates the risk assessment and management practice in the Russian Federation at different levels. The method is proposed to identify the territories characterized by integrated natural-technological hazard. The maps of the Russian Federation zoning according to the integrated natural-technological hazard level are presented, as well as the procedure of updating the integrated hazard level taking into account the activity of separate processes. Special attention is paid to data bases on past natural and technological processes consequences, which are used for verification of current hazard estimation. The examples of natural-technological risk zoning for the country and some regions territory are presented. Different output risk indexes: both social and economic, are estimated taking into account requirements of end-users. In order to increase the safety of population of the Russian Federation the trans-boundaries hazards are also taken into account.

  17. [The prevention of Ochratossina A (OTA A) in the wine].

    Science.gov (United States)

    Alonzo, Elena; Cafarella, Nicola; Duplicato, Giovanni; Maugeri, Antonio; Platania, Francesco; Raciti, Claudio; Fardella, Maristella

    2008-01-01

    The expansion of global market has recalled more and more the attention of the researchers on the presence of mycotoxins in the foodstuff. Trying to limit the damages to the health and the correlated economic losses the European Community has legislated fixing more restrictive limits for the presence of mycotoxins in the single food products; and, specifically the limits of presence of Ochratoxin A (OTA A) in the wines have been established by the rule EEC 123 / 2005. With the purpose to prevent the formation of OTA á in the wine (from the grape to the bottled product), has been conducted, a study to compare the different techniques currently used, as the Good Agricultural Practices (BPA), the Good Practices of Manufacture (BPF) and the Good Practices of storage (BPS) with the system of Hazard Analysis Critical Control Points (HACCP), nowadays used only from the begin of the phase of processing of the agricultural products. It results that, concerning the BPAs, the application of the System HACCP on the primary production would bring neither some innovation nor qualitative improvement. The comparison among BPF, BPS and HACCP, confirms, instead, as the HACCP allows to individualize a series of additional critical points worth of attention during the process and maintenance of the grapes. Such result is in agreement with the new community rule 852/2004, which, also because the difficulties in the application of the HACCP to the primary production, confirm the necessity to follow, on the field, the hygienic respect of the sanitary measures (see attached one artt. 5- 6). This involves the necessity of an increasing integration and cooperation among different professional workers (as hygienist and agronomist). That kind of cooperation is already in use (from year 2003), within the "progetto fito", started by the AUSL 3 of Catania, with the coordination of the Service Hygiene Food stuff and Nutrition (SIAN).

  18. Energy Effectiveness Assessment of Composting Technologies

    OpenAIRE

    Plūme, I.

    2006-01-01

    The incorrect biomass composting improperly results in considerable emission of greenhouse gases, loss of effluent and composting heat into environment. The composting heat and gases utilisation is especially suitable for plant enrichment and heating of greenhouses. The mathematical model is worked out for assessment of energy effectiveness and sustainability of biomass composting process. Coefficient of energy effectiveness for traditional litter manure composting technologies is 0.45 and ca...

  19. Use of technology in children's dietary assessment.

    Science.gov (United States)

    Boushey, C J; Kerr, D A; Wright, J; Lutes, K D; Ebert, D S; Delp, E J

    2009-02-01

    Information on dietary intake provides some of the most valuable insights for mounting intervention programmes for the prevention of chronic diseases. With the growing concern about adolescent overweight, the need to accurately measure diet becomes imperative. Assessment among adolescents is problematic as this group has irregular eating patterns and they have less enthusiasm for recording food intake. We used qualitative and quantitative techniques among adolescents to assess their preferences for dietary assessment methods. Dietary assessment methods using technology, for example, a personal digital assistant (PDA) or a disposable camera, were preferred over the pen and paper food record. There was a strong preference for using methods that incorporate technology such as capturing images of food. This suggests that for adolescents, dietary methods that incorporate technology may improve cooperation and accuracy. Current computing technology includes higher resolution images, improved memory capacity and faster processors that allow small mobile devices to process information not previously possible. Our goal is to develop, implement and evaluate a mobile device (for example, PDA, mobile phone) food record that will translate to an accurate account of daily food and nutrient intake among adolescents. This mobile computing device will include digital images, a nutrient database and image analysis for identification and quantification of food consumption. Mobile computing devices provide a unique vehicle for collecting dietary information that reduces the burden on record keepers. Images of food can be marked with a variety of input methods that link the item for image processing and analysis to estimate the amount of food. Images before and after the foods are eaten can estimate the amount of food consumed. The initial stages and potential of this project will be described.

  20. Quercetin protects human peripheral blood mononuclear cells from OTA-induced oxidative stress, genotoxicity, and inflammation.

    Science.gov (United States)

    Periasamy, Ramyaa; Kalal, Iravathy Goud; Krishnaswamy, Rajashree; Viswanadha, VijayaPadma

    2016-07-01

    Ochratoxin A (OTA) is one of the most abundant food-contaminating mycotoxins world wide, and is detrimental to human and animal health. This study evaluated the protective effect of quercetin against OTA-induced cytotoxicity, genotoxicity, and inflammatory response in lymphocytes. Cytotoxicity determined by MTT assay revealed IC20 value of OTA to be 20 µM, which was restored to near control values by pretreatment with quercetin. Oxidative stress parameters such as antioxidant enzymes, LPO and PCC levels indicated that quercetin exerted a protective effect on OTA-induced oxidative stress. Quercetin exerted an antigenotoxic effect on OTA-induced genotoxicity, by significantly reducing the number of structural aberrations in chromosomes and comet parameters like, % olive tail moment from 2.76 ± 0.02 to 0.56 ± 0.02 and % tail DNA from 56.23 ± 2.56 to 12.36 ± 0.56 as determined by comet assay. OTA-induced NO, TNF-α, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role. Our results demonstrate for the first time that quercetin exerts a cytoprotective effect against OTA-induced oxidative stress, genotoxicity, and inflammation in lymphocytes. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 855-865, 2016.

  1. Current Reports: Educating Scientists and Engineers: The View from OTA.

    Science.gov (United States)

    Morgan, Robert P.

    1989-01-01

    Compares two engineering education reports which urge the following needs and emphases: attract and retain minorities, retain students already in engineering school, and allow students to enter the engineering program at various levels. Criticizes the Office of Technology Assessment's report and supplies prescriptions for the future. (MVL)

  2. MIMO OTA Testing in Small Multi-Probe Anechoic Chamber Setups

    DEFF Research Database (Denmark)

    Llorente, Ines Carton; Fan, Wei; Pedersen, Gert F.

    2016-01-01

    OTA testing of MIMO capable terminals is often performed in large anechoic chambers, where planar waves impinging the test area are assumed. Furthermore, reflections from the chamber, and probe coupling are often considered negligible due to the large dimensions of the chamber. This paper...... investigates the feasibility of reducing the physical dimension of 2D multi-probe anechoic chamber setups for MIMO OTA testing, with the purpose of reducing the cost and space of the setup. In the paper, a channel emulation algorithm and chamber compensation technique are proposed for MIMO OTA testing in small...

  3. Verification of Emulated Channels in Multi-Probe Based MIMO OTA Testing Setup

    DEFF Research Database (Denmark)

    Fan, Wei; Carreño, Xavier; Nielsen, Jesper Ødum;

    2013-01-01

    Standardization work for MIMO OTA testing methods is currently ongoing, where a multi-probe anechoic chamber based solution is an important candidate. In this paper, the probes located on an OTA ring are used to synthesize a plane wave field in the center of the OTA ring. This paper investigates...... the extent to which we can approach the synthesized plane wave in practical measurement systems. Both single plane wave with certain AoA and multiple plane waves with different AoAs and power weightings are synthesized and measured. Deviations of the measured plane wave and the simulated plane wave field...

  4. Rail-to-rail low-power fully differential OTA utilizing adaptive biasing and partial feedback

    DEFF Research Database (Denmark)

    Tuan Vu, Cao; Wisland, Dag T.; Lande, Tor Sverre

    A fully differential rail-to-rail Operational Transconductance Amplifier (OTA) with improved DC-gain and reduced power consumption is proposed in this paper. By using the adaptive biasing circuit and two differential inputs, a low stand-by current can be obtained together with reduced power...... consumption. The DC-gain of the proposed OTA is improved by adding a partial feedback loop. A Common-Mode Feedback (CMFB) circuit is required for fully differential rail-to-rail operation. Simulations show that the OTA topology has a low stand-by power consumption of 96μW and a high FoM of 3.84 [(V...

  5. The development of health technology assessment.

    Science.gov (United States)

    Banta, David

    2003-02-01

    The field of health technology assessment (HTA) is still relatively new, but it has shown remarkable growth over the last decade, having spread first from the United States to Europe, and now to the entire world. HTA seeks to couple evidence with decision-making, and thus has similarities to evidence-based health care and evidence-based policy-making. The early history of HTA, beginning around 1975, reveals a first period of synthesising available evidence-principally that dealing with efficacy and cost-effectiveness of health care interventions-so as to put it in a format helpful to health policy-makers, especially those in national governments. From 1985 or so, the focus of the second period was on seeking more effective links with these policy-makers, particularly in Europe. The most recent period, beginning in the late 1990s, has been increasingly devoted to more effective dissemination and implementation in order to influence administrators and clinicians. While early assessments tended to focus on large, expensive, machine-based technologies, the scope has gradually widened to include smaller technologies, 'softer' technologies (such as counselling), and health care needs. Actual assessments have also taken on broader issues, such as organisational, social, and ethical implications. In the Member States of the European Union (EU), HTA activities are increasingly visible, and almost all now have a national focus for HTA associated with the Ministry of Health or its equivalent. Central and Eastern European countries are also developing HTA activities. Most recently, HTA has been highlighted by health policy documents from the European Commission. It seems likely that HTA will in the future be institutionalised in some form as part of EU activities.

  6. Tiger Team Assessment, Energy Technology Engineering Center

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    The Office Special Projects within the Office of Environment, Safety, and Health (EH) has the responsibility to conduct Tiger Team Assessments for the Secretary of Energy. This report presents the assessment of the buildings, facilities, and activities under the DOE/Rockwell Contract No. DE-AM03-76SF00700 for the Energy Technology Engineering Center (ETEC) and of other DOE-owned buildings and facilities at the Santa Susana Field Laboratory (SSFL) site in southeastern Ventura County, California, not covered under Contract No. DE-AM03-76SF00700, but constructed over the years under various other contracts between DOE and Rockwell International. ETEC is an engineering development complex operated for DOE by the Rocketdyne Division of Rockwell International Corporation. ETEC is located within SSFL on land owned by Rockwell. The balance of the SSFL complex is owned and operated by Rocketdyne, with the exception of a 42-acre parcel owned by the National Aeronautics and Space Administration (NASA). The primary mission of ETEC is to provide engineering, testing, and development of components related to liquid metals technology and to conduct applied engineering development of emerging energy technologies.

  7. Technology assessment of wind energy conversion systems

    Energy Technology Data Exchange (ETDEWEB)

    Meier, B. W.; Merson, T. J.

    1980-09-01

    Environmental data for wind energy conversion systems (WECSs) have been generated in support of the Technology Assessment of Solar Energy (TASE) program. Two candidates have been chosen to characterize the WECS that might be deployed if this technology makes a significant contribution to the national energy requirements. One WECS is a large machine of 1.5-MW-rated capacity that can be used by utilities. The other WECS is a small machine that is characteristic of units that might be used to meet residential or small business energy requirements. Energy storage systems are discussed for each machine to address the intermittent nature of wind power. Many types of WECSs are being studied and a brief review of the technology is included to give background for choosing horizontal axis designs for this study. Cost estimates have been made for both large and small systems as required for input to the Strategic Environmental Assessment Simulation (SEAS) computer program. Material requirements, based on current generation WECSs, are discussed and a general discussion of environmental impacts associated with WECS deployment is presented.

  8. ELECTRIC INFRASTRUCTURE TECHNOLOGY, TRAINING, AND ASSESSMENT PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    TREMEL, CHARLES L

    2007-06-28

    The objective of this Electric Infrastructure Technology, Training and Assessment Program was to enhance the reliability of electricity delivery through engineering integration of real-time technologies for wide-area applications enabling timely monitoring and management of grid operations. The technologies developed, integrated, tested and demonstrated will be incorporated into grid operations to assist in the implementation of performance-based protection/preventive measures into the existing electric utility infrastructure. This proactive approach will provide benefits of reduced cost and improved reliability over the typical schedule-based and as needed maintenance programs currently performed by utilities. Historically, utilities have relied on maintenance and inspection programs to diagnose equipment failures and have used the limited circuit isolation devices, such as distribution main circuit breakers to identify abnormal system performance. With respect to reliable problem identification, customer calls to utility service centers are often the sole means for utilities to identify problem occurrences and determine restoration methodologies. Furthermore, monitoring and control functions of equipment and circuits are lacking; thus preventing timely detection and response to customer outages. Finally, the two-way flow of real-time system information is deficient, depriving decision makers of key information required to effectively manage and control current electric grid demands to provide reliable customer service in abnormal situations. This Program focused on advancing technologies and the engineering integration required to incorporate them into the electric grid operations to enhance electrical system reliability and reduce utility operating costs.

  9. A low power 14 bit 51.2 kS/s double-sampling extended counting ADC with a class-AB OTA

    Science.gov (United States)

    Honglei, Chen; Dong, Wu; Yanzhao, Shen; Jun, Xu

    2012-09-01

    A 14 bit 51.2 kS/s extended counting analog to digital converter (EC-ADC) is presented. Two techniques are utilized to reduce its power consumption. First, a double-sampling configuration based on a fully-floating bilinear integrator is proposed to reduce the clock frequency. Second, a class-AB operational transconductance amplifier (OTA) is designed to improve the power efficiency. In addition, the chopping technique is used to eliminate the OTA flicker noise effect. The proposed ADC is fabricated in 0.18 μm CMOS technology with a core area of 0.04 mm2. At a 51.2 kS/s conversion rate, it achieves a 94 dB SFDR and an 11.6 bit ENOB, while consuming only 77 μW from a 1.8 V power supply. The figure of merit is only 0.48 pJ/step.

  10. ['Medical technology assessment'; more than just efficacy].

    Science.gov (United States)

    Buskens, E

    2000-03-25

    'Medical technology assessment' means investigating the developments, costs and effects of medical technologies. Practising physicians increasingly are confronted with consequences of management based on such research results. In order to follow and participate in the discussion they should be aware of this and know the jargon. In policy problems, measures of effect in natural units (e.g. cardiovascular mortality) offer advantages over measures of clinical findings (e.g. decrease of the serum cholesterol levels). Survival in various health states and disorders can be compared by multiplying the number of life years gained by a factor for the quality of life in those years. Costs are usually expressed in monetary terms. These may be calculated as direct medical costs on the basis of fees or actual costs for society. The latter is the case when the balancing is based on a societal perspective. The societal perspective enables a more objective assessment of health effects than when a patient perspective is used. 'Incremental cost effectiveness' expresses where extra expenditures will have maximum effect, and bears higher relevance for policy decisions than mean costs per unit of effect. Immaterial matters are more difficult to assess, but should nevertheless be considered in selecting the policy to be implemented.

  11. Technology Assessment Need: Review on Attractiveness and Competitiveness

    Science.gov (United States)

    Salwa Sait, Siti; Merlinda Muharam, Farrah; Chin, Thoo Ai; Sulaiman, Zuraidah

    2017-06-01

    Technology assessment is crucial in managing technology for the purpose of technology exploitation. With business environment continuously changing, firms have to address this issue critically as technology is considered one of the important elements to evaluate performance and gain competitive advantage. Missteps in deciding the best technology to be developed, employed or maintained would cost the firm overall value. To fulfil the need of finding the appropriate scale to assess suitable technology, this paper summarizes that technology assessment (TA) should cover two main aspects, namely technology attractiveness and competitiveness. These components are seen capable to link the scale suggested towards evaluation of financial and non-financial performance towards competitive advantage.

  12. Assessing the performance of health technology assessment organizations: a framework.

    Science.gov (United States)

    Lafortune, Louise; Farand, Lambert; Mondou, Isabelle; Sicotte, Claude; Battista, Renaldo

    2008-01-01

    In light of growing demands for public accountability, the broadening scope of health technology assessment organizations (HTAOs) activities and their increasing role in decision-making underscore the importance for them to demonstrate their performance. Based on Parson's social action theory, we propose a conceptual model that includes four functions an organization needs to balance to perform well: (i) goal attainment, (ii) production, (iii) adaptation to the environment, and (iv) culture and values maintenance. From a review of the HTA literature, we identify specific dimensions pertaining to the four functions and show how they relate to performance. We compare our model with evaluations reported in the scientific and gray literature to confirm its capacity to accommodate various evaluation designs, contexts of evaluation, and organizational models and perspectives. Our findings reveal the dimensions of performance most often assessed and other important ones that, hitherto, remain unexplored. The model provides a flexible and theoretically grounded tool to assess the performance of HTAOs.

  13. A conceptual framework for energy technology sustainability assessment

    CSIR Research Space (South Africa)

    Musango, Josephine K

    2011-03-01

    Full Text Available the framework of incorporating the system dynamics methodology in energy technology assessment theory and practice within the context of sustainable development. The framework provides for technology sustainability assessment, which, in turn, can guide...

  14. Tool for Military Logistics Planning of Peace Support Operations: The OTAS Planning Tool

    NARCIS (Netherlands)

    Merrienboer, S.A. van

    1998-01-01

    Within the research group Operations Research Studies Army of the TNO Physics and Electronics Laboratory the OTAS planning tool is developed for the Royal Netherlands Armed Forces. This paper gives a general and brief description of the tool.

  15. Unilateral open-angle glaucoma associated with the ipsilateral nevus of ota.

    Science.gov (United States)

    Magarasevic, Lidija; Abazi, Zihret

    2013-01-01

    The nevus of Ota also known as "congenital melanosis bulbi" and "oculodermal melanocytosis" is a blue-gray hyperpigmentation that occurs on the face and eyes. The sclera is involved in two-thirds of cases (causing an increased risk of glaucoma). Women are nearly five times more likely to be affected than men. It is rare among Caucasian people. The nevus of Ota is congenital or acquired. Most cases of the nevus of Ota are unilateral (90%), although pigmentation is present bilaterally in 5%-10%. Ocular abnormalities included pigmentation of the sclera, cornea, retina, and optic disc and cavernous hemangiomas of the optic disc, elevated intraocular pressure, glaucoma, and ocular melanoma. We reported an appearance of unilateral glaucoma in a Caucasian female patient with the acquired, ipsilateral nevus of Ota.

  16. Unilateral Open-Angle Glaucoma Associated with the Ipsilateral Nevus of Ota

    Directory of Open Access Journals (Sweden)

    Lidija Magarasevic

    2013-01-01

    Full Text Available The nevus of Ota also known as “congenital melanosis bulbi” and “oculodermal melanocytosis” is a blue-gray hyperpigmentation that occurs on the face and eyes. The sclera is involved in two-thirds of cases (causing an increased risk of glaucoma. Women are nearly five times more likely to be affected than men. It is rare among Caucasian people. The nevus of Ota is congenital or acquired. Most cases of the nevus of Ota are unilateral (90%, although pigmentation is present bilaterally in 5%–10%. Ocular abnormalities included pigmentation of the sclera, cornea, retina, and optic disc and cavernous hemangiomas of the optic disc, elevated intraocular pressure, glaucoma, and ocular melanoma. We reported an appearance of unilateral glaucoma in a Caucasian female patient with the acquired, ipsilateral nevus of Ota.

  17. Constructive technology assessment of gene expression profiling for breast cancer

    NARCIS (Netherlands)

    Retèl, Valesca Pavlawna

    2011-01-01

    Constructive Technology Assessment (CTA) can be used as a complementary approach to Health Technology Assessment (HTA), especially for the early and dynamic introduction of new technologies in a controlled way. CTA is based on the idea that during the course of technology development, choices are co

  18. Mobile technology for mental health assessment.

    Science.gov (United States)

    Areàn, Patricia A; Hoa Ly, Kien; Andersson, Gerhard

    2016-06-01

    Assessment and outcome monitoring are critical for the effective detection and treatment of mental illness. Traditional methods of capturing social, functional, and behavioral data are limited to the information that patients report back to their health care provider at selected points in time. As a result, these data are not accurate accounts of day-to-day functioning, as they are often influenced by biases in self-report. Mobile technology (mobile applications on smartphones, activity bracelets) has the potential to overcome such problems with traditional assessment and provide information about patient symptoms, behavior, and functioning in real time. Although the use of sensors and apps are widespread, several questions remain in the field regarding the reliability of off-the-shelf apps and sensors, use of these tools by consumers, and provider use of these data in clinical decision-making.

  19. Design of Low-Power CMOS OTA Using Bulk-Drive Technique

    OpenAIRE

    2015-01-01

    This paper presents the design of low power CMOS- OTA (operational transconductance amplifier) using bulk drive (BD) technique with broad band. This technique is used for design of low power circuits with broad band for high frequency users, for example communication systems, mobile communication and communication forming of medical electronics. OTA is the base of amplifier .It is a fundamental building part of analog systems. Recently analog designer has been paid to low voltage (LV),low pow...

  20. [Indirect costs in health technology assessment].

    Science.gov (United States)

    Jakubczyk, Michał; Wrona, Witold; Macioch, Tomasz; Golicki, Dominik; Niewada, Maciej; Hermanowski, Tomasz

    2010-01-01

    In the health technology assessment it is crucial to define the perspective of the analysis. When the societal perspective is chosen it is necessary to include all the costs incurred by the society, also the costs of lost productivity resulting from absence of sick employees from work or their reduced efficiency at work. The aim of this article is to present the notion of indirect costs, their importance in health technology assessment and the methods of calculation. The economic literature has been reviewed for the state of knowledge on indirect costs. Three methods of calculation are described: human capital method, friction cost method or health state valuation. Indirect costs in Western European countries can amount to more than half of total costs attributed to the illness and its treatment. In the literature there is no consensus regarding the proper method of indirect costs calculation. It is necessary to conduct further theoretical and empirical research in the area of indirect costs and enhance discussion among Polish pharmacoeconomists.

  1. RNA-Seq Reveals OTA-Related Gene Transcriptional Changes in Aspergillus carbonarius.

    Science.gov (United States)

    Gerin, Donato; De Miccolis Angelini, Rita M; Pollastro, Stefania; Faretra, Francesco

    2016-01-01

    Ochratoxin A (OTA) is a mycotoxin harmful for animals and humans. Aspergillus carbonarius is the main responsible for OTA contamination of grapes and derived products. Gene transcriptional profiling of 4 A. carbonarius strains was carried out by RNA-Seq analysis to study transcriptome changes associated with OTA production. By comparing OTA inducing (OTAI) vs. non-inducing (OTAN) cultural conditions, a total of 3,705 differentially expressed genes (DEGs) (fold change > |2| and FDR ≤ 0.05) were identified. Several genes involved in primary metabolic processes, with particular regard to carbohydrate and amino acid metabolisms, secondary metabolic processes, transport, response to stress and sporulation were up-regulated by OTAI conditions at all the analysed sampling times (4, 6 and 8 DAI) or starting from 6 DAI. Highly up-regulated DEGs encoding enzymes involved in biosynthesis of secondary metabolites, oxidoreductases, transporters and transcription factors were examined for their potential involvement in OTA biosynthesis and related metabolic pathways. Differential expression of genes encoding polyketide synthases (pks), non-ribosomal peptide synthetases (nrps) and chloroperoxidase (cpo) was validated by RT-qPCR. Among clusters of co-regulated genes involved in SM biosynthesis, one putative OTA-gene cluster, including both pks and nrps genes, was detected in the A. carbonarius genome.

  2. RNA-Seq Reveals OTA-Related Gene Transcriptional Changes in Aspergillus carbonarius.

    Directory of Open Access Journals (Sweden)

    Donato Gerin

    Full Text Available Ochratoxin A (OTA is a mycotoxin harmful for animals and humans. Aspergillus carbonarius is the main responsible for OTA contamination of grapes and derived products. Gene transcriptional profiling of 4 A. carbonarius strains was carried out by RNA-Seq analysis to study transcriptome changes associated with OTA production. By comparing OTA inducing (OTAI vs. non-inducing (OTAN cultural conditions, a total of 3,705 differentially expressed genes (DEGs (fold change > |2| and FDR ≤ 0.05 were identified. Several genes involved in primary metabolic processes, with particular regard to carbohydrate and amino acid metabolisms, secondary metabolic processes, transport, response to stress and sporulation were up-regulated by OTAI conditions at all the analysed sampling times (4, 6 and 8 DAI or starting from 6 DAI. Highly up-regulated DEGs encoding enzymes involved in biosynthesis of secondary metabolites, oxidoreductases, transporters and transcription factors were examined for their potential involvement in OTA biosynthesis and related metabolic pathways. Differential expression of genes encoding polyketide synthases (pks, non-ribosomal peptide synthetases (nrps and chloroperoxidase (cpo was validated by RT-qPCR. Among clusters of co-regulated genes involved in SM biosynthesis, one putative OTA-gene cluster, including both pks and nrps genes, was detected in the A. carbonarius genome.

  3. RNA-Seq Reveals OTA-Related Gene Transcriptional Changes in Aspergillus carbonarius

    Science.gov (United States)

    Gerin, Donato; De Miccolis Angelini, Rita M.; Pollastro, Stefania; Faretra, Francesco

    2016-01-01

    Ochratoxin A (OTA) is a mycotoxin harmful for animals and humans. Aspergillus carbonarius is the main responsible for OTA contamination of grapes and derived products. Gene transcriptional profiling of 4 A. carbonarius strains was carried out by RNA-Seq analysis to study transcriptome changes associated with OTA production. By comparing OTA inducing (OTAI) vs. non-inducing (OTAN) cultural conditions, a total of 3,705 differentially expressed genes (DEGs) (fold change > |2| and FDR ≤ 0.05) were identified. Several genes involved in primary metabolic processes, with particular regard to carbohydrate and amino acid metabolisms, secondary metabolic processes, transport, response to stress and sporulation were up-regulated by OTAI conditions at all the analysed sampling times (4, 6 and 8 DAI) or starting from 6 DAI. Highly up-regulated DEGs encoding enzymes involved in biosynthesis of secondary metabolites, oxidoreductases, transporters and transcription factors were examined for their potential involvement in OTA biosynthesis and related metabolic pathways. Differential expression of genes encoding polyketide synthases (pks), non-ribosomal peptide synthetases (nrps) and chloroperoxidase (cpo) was validated by RT-qPCR. Among clusters of co-regulated genes involved in SM biosynthesis, one putative OTA-gene cluster, including both pks and nrps genes, was detected in the A. carbonarius genome. PMID:26765536

  4. Life cycle assessment of biogas upgrading technologies.

    Science.gov (United States)

    Starr, Katherine; Gabarrell, Xavier; Villalba, Gara; Talens, Laura; Lombardi, Lidia

    2012-05-01

    This article evaluates the life cycle assessment (LCA) of three biogas upgrading technologies. An in-depth study and evaluation was conducted on high pressure water scrubbing (HPWS), as well as alkaline with regeneration (AwR) and bottom ash upgrading (BABIU), which additionally offer carbon storage. AwR and BABIU are two novel technologies that utilize waste from municipal solid waste incinerators - namely bottom ash (BA) and air pollution control residues (APC) - and are able to store CO(2) from biogas through accelerated carbonation processes. These are compared to high pressure water scrubbing (HPWS) which is a widely used technology in Europe. The AwR uses an alkaline solution to remove the CO(2) and then the solution - rich in carbonate and bicarbonate ions - is regenerated through carbonation of APC. The BABIU process directly exposes the gas to the BA to remove and immediately store the CO(2), again by carbonation. It was determined that the AwR process had an 84% higher impact in all LCA categories largely due to the energy intensive production of the alkaline reactants. The BABIU process had the lowest impact in most categories even when compared to five other CO(2) capture technologies on the market. AwR and BABIU have a particularly low impact in the global warming potential category as a result of the immediate storage of the CO(2). For AwR, it was determined that using NaOH instead of KOH improves its environmental performance by 34%. For the BABIU process the use of renewable energies would improve its impact since accounts for 55% of the impact. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Drug delivery system innovation and Health Technology Assessment: Upgrading from Clinical to Technological Assessment.

    Science.gov (United States)

    Panzitta, Michele; Bruno, Giorgio; Giovagnoli, Stefano; Mendicino, Francesca R; Ricci, Maurizio

    2015-11-30

    Health Technology Assessment (HTA) is a multidisciplinary health political instrument that evaluates the consequences, mainly clinical and economical, of a health care technology; the HTA aim is to produce and spread information on scientific and technological innovation for health political decision making process. Drug delivery systems (DDS), such as nanocarriers, are technologically complex but they have pivotal relevance in therapeutic innovation. The HTA process, as commonly applied to conventional drug evaluation, should upgrade to a full pharmaceutical assessment, considering the DDS complexity. This is useful to study more in depth the clinical outcome and to broaden its critical assessment toward pharmaceutical issues affecting the patient and not measured by the current clinical evidence approach. We draw out the expertise necessary to perform the pharmaceutical assessment and we propose a format to evaluate the DDS technological topics such as formulation and mechanism of action, physicochemical characteristics, manufacturing process. We integrated the above-mentioned three points in the Evidence Based Medicine approach, which is data source for any HTA process. In this regard, the introduction of a Pharmaceutics Expert figure in the HTA could be fundamental to grant a more detailed evaluation of medicine product characteristics and performances and to help optimizing DDS features to overcome R&D drawbacks. Some aspects of product development, such as manufacturing processes, should be part of the HTA as innovative manufacturing processes allow new products to reach more effectively patient bedside. HTA so upgraded may encourage resource allocating payers to invest in innovative technologies and providers to focus on innovative material properties and manufacturing processes, thus contributing to bring more medicines in therapy in a sustainable manner.

  6. Technology in Schools: Suggestions, Tools and Guidelines for Assessing Technology in Elementary and Secondary Education.

    Science.gov (United States)

    Ogle, Tom; Branch, Morgan; Canada, Bethann; Christmas, Oren; Clement, John; Fillion, Judith; Goddard, Ed; Loudat, N. Blair; Purwin, Tom; Rogers, Andy; Schmitt, Carl; Vinson, Mike

    This handbook is intended to facilitate the assessment of technology used to support elementary and secondary education in the United States. It is designed to help decision makers and technology users prepare, collect and assess information about whether and how technology is being used in their school systems. To make assessments that will be…

  7. Multiobjective Genetic Algorithms Program for the Optimization of an OTA for Front-End Electronics

    Directory of Open Access Journals (Sweden)

    Abdelghani Dendouga

    2014-01-01

    Full Text Available The design of an interface to a specific sensor induces costs and design time mainly related to the analog part. So to reduce these costs, it should have been standardized like digital electronics. The aim of the present work is the elaboration of a method based on multiobjectives genetic algorithms (MOGAs to allow automated synthesis of analog and mixed systems. This proposed methodology is used to find the optimal dimensional transistor parameters (length and width in order to obtain operational amplifier performances for analog and mixed CMOS-(complementary metal oxide semiconductor- based circuit applications. Six performances are considered in this study, direct current (DC gain, unity-gain bandwidth (GBW, phase margin (PM, power consumption (P, area (A, and slew rate (SR. We used the Matlab optimization toolbox to implement the program. Also, by using variables obtained from genetic algorithms, the operational transconductance amplifier (OTA is simulated by using Cadence Virtuoso Spectre circuit simulator in standard TSMC (Taiwan Semiconductor Manufacturing Company RF 0.18 μm CMOS technology. A good agreement is observed between the program optimization and electric simulation.

  8. High-Precision CMOS Analog Computational Circuits Based on a New Linearly Tunable OTA

    Directory of Open Access Journals (Sweden)

    A. Naderi Saatlo

    2016-06-01

    Full Text Available Implementation of CMOS current-mode analog computational circuits are presented in this paper. A new Linearly Tunable OTA is employed in a modified structure as a basic building block for implementation of the circuits either linear or nonlinear functions. The proposed trans-conductance amplifier provides a constant Gm over a wide range of input voltage which allows the implementation of high precision computational circuits including square rooting, squaring, multiplication and division functions. Layout pattern of the proposed circuit confirms that the circuit can be implemented in 102μm*69μm active area. In order to verify the performance of the circuits, the post layout simulation results are presented through the use of HSPICE and Cadence with TSMC level 49 (BSIM3v3 parameters for 0.18 μm CMOS technology, where under supply voltage of 1.8 V, the maximum relative error of the circuits within 500 µA of input range is about 11 μA (2.2 % error and the THD remains as low as 1.2 % for the worst case. Moreover, the power dissipation of the complete structure is found to be 0.66 mW.

  9. What Do They Understand? Using Technology to Facilitate Formative Assessment

    Science.gov (United States)

    Mitten, Carolyn; Jacobbe, Tim; Jacobbe, Elizabeth

    2017-01-01

    Formative assessment is so important to inform teachers' planning. A discussion of the benefits of using technology to facilitate formative assessment explains how four primary school teachers adopted three different apps to make their formative assessment more meaningful and useful.

  10. Robustness of digital approach to mismatch compensation in analog circuits realized in nanometer technologies

    Science.gov (United States)

    Jaworski, Zbigniew; Wysokiński, Piotr

    2013-07-01

    In this papers, a fully differential operational transconductance amplifier (OTA) implemented in 65 nm CMOS technology is analyzed to determine which component of the calibration circuitry is most susceptible to manufacturing process disturbances and thus impairs robustness of the calibration methodology. The average offset voltage of the OTA can be significantly reduced. It has been shown that effectiveness of the calibration methodology is limited by the offset voltage of the comparator that calculates sign of the OTA offset voltage.

  11. Technology-Based Classroom Assessments: Alternatives to Testing

    Science.gov (United States)

    Salend, Spencer J.

    2009-01-01

    Although many teachers are using new technologies to differentiate instruction and administer tests, educators are also employing a range of technology-based resources and strategies to implement a variety of classroom assessments as alternatives to standardized and teacher-made testing. Technology-based classroom assessments focus on the use of…

  12. Technology-Based Classroom Assessments: Alternatives to Testing

    Science.gov (United States)

    Salend, Spencer J.

    2009-01-01

    Although many teachers are using new technologies to differentiate instruction and administer tests, educators are also employing a range of technology-based resources and strategies to implement a variety of classroom assessments as alternatives to standardized and teacher-made testing. Technology-based classroom assessments focus on the use of…

  13. 75 FR 79354 - Assessment Technology Standards Request for Information (RFI)

    Science.gov (United States)

    2010-12-20

    ..., virtual worlds, mobile devices, and simulations. 3.2.28 Accessibility. How do technology standards ensure... Assessment Technology Standards Request for Information (RFI) AGENCY: Office of Innovation and Improvement, U... pertaining to assessment technology standards. SUMMARY: The purpose of this RFI is to collect...

  14. Differential Cell Sensitivity between OTA and LPS upon Releasing TNF-α

    Directory of Open Access Journals (Sweden)

    Lauy Al-Anati

    2010-06-01

    Full Text Available The release of tumor necrosis factor α (TNF-α by ochratoxin A (OTA was studied in various macrophage and non-macrophage cell lines and compared with E. coli lipopolysaccharide (LPS as a standard TNF-α release agent. Cells were exposed either to 0, 2.5 or 12.5 µmol/L OTA, or to 0.1 µg/mL LPS, for up to 24 h. OTA at 2.5 µmol/L and LPS at 0.1 µg/mL were not toxic to the tested cells as indicated by viability markers. TNF-a was detected in the incubated cell medium of rat Kupffer cells, peritoneal rat macrophages, and the mouse monocyte macrophage cell line J774A.1: TNF-a concentrations were 1,000 pg/mL, 1,560 pg/mL, and 650 pg/mL, respectively, for 2.5 µmol/L OTA exposure and 3,000 pg/mL, 2,600 pg/mL, and 2,115 pg/mL, respectively, for LPS exposure. Rat liver sinusoidal endothelial cells, rat hepatocytes, human HepG2 cells, and mouse L929 cells lacked any cytokine response to OTA, but showed a significant release of TNF-a after LPS exposure, with the exception of HepG2 cells. In non-responsive cell lines, OTA lacked both any activation of NF-κB or the translocation of activated NF-κB to the cell nucleus, i.e., in mouse L929 cells. In J774A.1 cells, OTA mediated TNF-a release via the pRaf/MEK 1/2–NF-κB and p38-NF-κB pathways, whereas LPS used pRaf/MEK 1/2-NF-κB, but not p38-NF-κB pathways. In contrast, in L929 cells, LPS used other pathways to activate NF-κB. Our data indicate that only macrophages and macrophage derived cells respond to OTA and are considered as sources for TNF-a release upon OTA exposure.

  15. Assessing the impact of new technology on complex sociotechnical systems

    CSIR Research Space (South Africa)

    Oosthuizen, R

    2016-08-01

    Full Text Available African Journal of Industrial Engineering Month Year Vol __(_) pp 1-3 ASSESSING THE IMPACT OF NEW TECHNOLOGY ON COMPLEX SOCIOTECHNICAL SYSTEMS R. Oosthuizen & L. Pretorius Department of Engineering and Technology Management University of Pretoria...

  16. Dietary assessment in Africa: Integration with innovative technology ...

    African Journals Online (AJOL)

    Dietary assessment in Africa: Integration with innovative technology. ... African Journal of Food, Agriculture, Nutrition and Development ... an opportunity for exploring the benefits and general acceptance of using technology to improve health.

  17. Space Launch System Upper Stage Technology Assessment

    Science.gov (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy

    2014-01-01

    discussed in light of the various missions. For each mission there are several trajectory options and each will be discussed in terms of delta-v required and transit duration. Each propulsion system will be modeled, sized, and judged based on their applicability to the whole range of beyond LEO missions. Criteria for scoring will include the resulting dry mass of the stage, resulting propellant required, time to destination, and an assessment of key enabling technologies. In addition to the larger metrics, this paper will present the results of several coupled sensitivity studies. The ultimate goals of these tools and studies are to provide NASA with the most mass-, technology-, and cost-effective in-space stage for its future exploration missions.

  18. Treatment of nevus of Ota by the Q-switched alexandrite laser.

    Science.gov (United States)

    Alster, T S; Williams, C M

    1995-07-01

    The Q-switched alexandrite laser (755 nm, 100 nanoseconds) selectively targets and destroys cutaneous pigment such as that found in dermal pigmented lesions and tattoos. The nevus of Ota is a benign dermal melanocytic lesion, which, due to its large size and periocular location, has been notoriously difficult to treat. Utilizing the principles of selective photothermolysis, the alexandrite laser could effect an excellent treatment for nevus of Ota. To report the effectiveness of the Q-switched alexandrite laser in treating nevus of Ota. Seven patients with nevus of Ota were treated with the Q-switched alexandrite laser (755 nm, 100 nanoseconds) with energy densities ranging from 4.75 to 7.0 J/cm2 at 8-12-week intervals. Response to therapy was evaluated through independent observation and rating of sequential photographs by two blinded observers. Histologic examinations of lesional skin biopsies before and after completion of laser treatments were performed. An average of two laser treatments were required to effect an average clinical improvement of 50%. Five patients showed 100% lesional clearance after an average of five treatments. No scarring, textural changes, or pigmentary side effects were observed in treated skin. Histology of laser-irradiated lesions revealed elimination of upper dermal pigmentation without epidermal disruption, and rare melanophages and pigmented spindle cells in the deep reticular dermis. No lesional recurrences were observed up to 1 year following treatment. The Q-switched alexandrite laser can effectively eliminate nevus of Ota without untoward side effects, such as scarring.

  19. DoD Current State for Software Technology Readiness Assessments

    Science.gov (United States)

    2010-04-01

    DoD Current State for Software Technology Readiness Assessments Systems & Software Technology Conference April 2010 Cynthia Dion-Schwarz, Ph.D...DoD Current State for Software Technology Readiness Assessments 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...public release; distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the 22nd Systems and Software Technology Conference (SSTC), 26-29 April

  20. Expanding the applicability of Heallth Technology Assessments

    DEFF Research Database (Denmark)

    Draborg, Eva; Hansen, Helle Ploug

    2012-01-01

    external validity and the effectiveness of a technology in normal daily practice. SR and HTAs favors internal valid trials and thereby proofs of possible cause-effect relationship between a technology and outcomes but at the expense of the wider perspectives of a technology. HTA have a policy...

  1. Assessment of Ga2O3 technology

    Science.gov (United States)

    2016-09-15

    architecture [60]. ....................................................................... 10 Figure 5: Photograph of 4-inch diameter Ga2O3 wafer...breakdown voltages can provide orders of magnitude reduction in system size, cost and weight. Figure 4: A More-Electric Aircraft (MEA) architecture [60...Technology base is narrowly located in Japan . Mainstream technology. Czochralski • Mature technology base. • Crucible-free crystal growth

  2. History of healthcare technology assessment in Japan.

    Science.gov (United States)

    Hisashige, Akinori

    2009-07-01

    There has been a rapid growth of healthcare technology assessment (HTA) activities among health service researchers and physicians in Japan in the younger generation since the mid-1980s. HTA has become visible since the Ministry of Health, Labor, and Welfare (MHLW) set up the several committees related to HTA in the late 1990s. The MHLW had to participate in regulatory and administrative reform, coping with the serious economic stagnation since 1991, following the economic recession in the 1980s. However, HTA has not been developed as expected. The most important failure is that the application of HTA to health policy has been neglected by the MHLW. Only application to clinical practice has been implemented by developing evidence-based clinical practice guidelines. The MHLW had the main aim of containing costs by reducing excess or useless healthcare services through guidelines, rather than to implement a radical reform. Without a central organization for HTA, several researchers have still continued to do HTA studies, but most researchers and physicians promoting HTA have been moved into diverse related areas. Ultimately, increasing efficiency may be the only way of reconciling rising demands for health care with public financing constraints. Therefore, the reconsideration and reorganization of HTA, which covers not only healthcare services but also the healthcare system as a whole, is becoming an urgent matter for healthcare reform.

  3. Life cycle assessment of emerging technologies

    DEFF Research Database (Denmark)

    Valsasina, Lucia; Pizzol, Massimo; Smetana, Sergiy;

    2017-01-01

    Abstract Milk is becoming a key food commodity as population grows and demand increases. The treatment of milk to extend its shelf life is thus an important step in avoiding losses and optimizing resource use. The drawbacks of the most common treatments for shelf stable milk are the loss of nutri......Abstract Milk is becoming a key food commodity as population grows and demand increases. The treatment of milk to extend its shelf life is thus an important step in avoiding losses and optimizing resource use. The drawbacks of the most common treatments for shelf stable milk are the loss...... shelf life. A life cycle assessment was performed comparing this emerging technology to the common thermal treatment: indirect ultra-high temperature sterilisation combined with non-aseptic homogenisation. The results show that high-pressure based processing has a lower environmental burden compared...... to the high-temperature based processing, already at pilot-scale, and this difference is primarily due to the lower electricity consumption. Additionally, upscaling considerations were made using power laws and scenario analysis to simulate future full-scale applications of UHPH. The upscaling shows...

  4. Design of high-order elliptic filter from a versatile mode generic OTA-C structure

    Science.gov (United States)

    Ghosh, K.; Ray, B. N.

    2015-03-01

    A new synthesis methodology for high-order versatile mode programmable Operational transconductance amplifier and capacitor (OTA-C) generic filter structure is proposed. The structure fulfills the three main criteria of high frequency operation i.e it uses (1) less number of components (2) only single ended input OTAs (3) only grounded capacitors. Any nth order transfer function can be realised from it. Elliptic filter is designed from the generic structure using optimisation technique to reduce the number of OTAs. SPICE simulation with BSIM level 53 model and 0.13 μm process confirms the theoretical analysis. Frequency response of third-order and fourth-order elliptic filter is shown as representative set of simulated result. Sensitivity and non-ideal effect of the designed filter are studied.

  5. Detailed study of particle detectors OTA-based CMOS Semi-Gaussian shapers

    Science.gov (United States)

    Noulis, T.; Deradonis, C.; Siskos, S.; Sarrabayrouse, G.

    2007-12-01

    An analysis of readout front-end electronics Semi-Gaussian (S-G) shapers is carried out. An innovative design methodology is proposed and advanced filter design techniques based on Operational Transconductance Amplifiers (OTA) are used. Five CMOS shaper topologies are designed using OTAs and compared in terms of noise performance, total harmonic distortion, dynamic range and power consumption in order to examine which is the most preferable in readout applications. Although all shaper architectures are fully integrated, they exhibit a large peaking time. The results are obtained from SPICE simulations for implementations in a 0.6 μm process of Austria Mikro Systeme (AMS).

  6. Report of rare palatal expression of Nevus of Ota with amendment of Tanino's classification.

    Science.gov (United States)

    Guledgud, Mahima V; Patil, Karthikeya; Srivathsa, Srikanth H; Malleshi, Suchetha N

    2011-01-01

    Nevus of Ota, a benign melanocytic pigmentary disorder with rare malignant transformation potential, affects 0.014-0.034% of the Asian and Black population and has a strong predilection for females. It occurs in the area innervated by the first and second division of the trigeminal nerve. Oral manifestation is rarely noted with only 14 cases reported till date. This report documents a case of Nevus of Ota with the infrequently noted oral involvement, in an Indian lady. Since oral manifestation is not acknowledged in Tanino's classification, the authors propose a modification to the same.

  7. Report of rare palatal expression of Nevus of Ota with amendment of Tanino′s classification

    Directory of Open Access Journals (Sweden)

    Mahima V Guledgud

    2011-01-01

    Full Text Available Nevus of Ota, a benign melanocytic pigmentary disorder with rare malignant transformation potential, affects 0.014-0.034% of the Asian and Black population and has a strong predilection for females. It occurs in the area innervated by the first and second division of the trigeminal nerve. Oral manifestation is rarely noted with only 14 cases reported till date. This report documents a case of Nevus of Ota with the infrequently noted oral involvement, in an Indian lady. Since oral manifestation is not acknowledged in Tanino′s classification, the authors propose a modification to the same.

  8. A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota.

    Science.gov (United States)

    Wen, Xiang; Li, Yong; Jiang, Xian

    2016-01-01

    Different types of Q-switched (QS) lasers have been used successfully to treat nevus of Ota. The purpose of this study was to compare the clinical efficacy and complication of QS alexandrite (QS Alex) laser versus QS neodymium:yttrium aluminum garnet (Nd:YAG) (QS Nd:YAG) laser for bilateral nevus of Ota. Seventeen patients with bilateral nevus of Ota were treated randomly with QS Alex in one half of face and QS Nd:YAG in the other half with an interval of at least 3 months between each. Subjective assessment was made by both patients and dermatologists. Patients were also examined for evidence of complications. All patients experienced improvement (p 0.05). The pain after a short period of laser therapy was more severe for QS Alex than for QS Nd:YAG laser. Vesicles developed in 1 patient after QS Alex therapy. Both QS Alex laser and QS Nd:YAG laser were equally effective at improving bilateral nevus of Ota. Patients tolerate QS Nd:YAG laser better than QS Alex laser.

  9. Recent Advances on OTA Testing for 5G Antenna Systems in Multi-probe Anechoic Chamber Setups

    DEFF Research Database (Denmark)

    Fan, Wei; Pedersen, Gert F.; Kyösti, Pekka

    2017-01-01

    Over-the-air (OTA) testing is seen as an essential method for evaluating 5G antenna systems, since conventional cable testing are no longer applicable. In the paper, we discussed the similarities and discrepancies of OTA testing in the multiprobe anechoic chamber (MPAC) setups for 4G user equipment...

  10. Rapid Technology Assessment Framework for Land Logistics

    Science.gov (United States)

    2015-03-01

    Economy, Environment, Politics SWOT Strengths, Weaknesses, Opportunities, Threats TRL Technology Readiness Level US United States WHO World Health...structures, processes • Contract management Capability Life -Cycle Management (in support of force modernisation and preparedness...commonly based on projections of the global meta-trends across the physical, social and technological environments. Such discussions are numerous

  11. Beyond checklists: toward an ethical-constructive technology assessment

    NARCIS (Netherlands)

    Kiran, Asle; Oudshoorn, Nelly E.J.; Verbeek, Peter P.C.C.

    2015-01-01

    While many technology assessments (TAs) formally conducted by TA organizations in Europe and the USA have examined the implications of new technologies for ‘quantifiable risks’ regarding safety, health or the environment, they have largely ignored the ethical implications of those technologies.

  12. Methodology of constructive technology assessment in health care

    NARCIS (Netherlands)

    Douma, Kirsten F.L.; Karsenberg, Kim; Hummel, Marjan J.M.; Bueno-de-Mesquita, Jolien M.; Harten, van Wim H.

    2007-01-01

    Objectives: Technologies in health care are evolving quickly, with new findings in the area of biotechnological and genetic research being published regularly. A health technology assessment (HTA) is often used to answer the question of whether the new technology should be implemented into clinical

  13. Assessing the degradation of ochratoxin a using a bioassay : the case of contaminated winery wastewater

    OpenAIRE

    2006-01-01

    In vineyards the presence of certain fungi may lead to the production of the mycotoxin ochratoxin A (OTA) and subsequent contamination of grapes and wine. Furthermore, winery wastewaters contaminated with OTA may represent an environmental hazard. Therefore, it is imperative to assess the fate of this mycotoxin in conventional wastewater treatment systems. The aim of the present work was to assess the biological degradation of OTA. Experimental work was carried out in batch experi...

  14. Decision Gate Process for Assessment of a Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna; Hyatt, Mark

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to TRL 6 development level) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, which will reduce life cycle cost and risk, and will increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product is either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  15. New Modes of Constructive Technology Assessment for Developing Countries

    DEFF Research Database (Denmark)

    Christensen, David; Remmen, Arne

    . Technology assessment helps assess the potential positive or negative impacts following in the wake of introducing a new technology of any conceivable type. It has an overall philosophy of reducing the cost of learning in society’s handling of new technologies, anticipating impacts and feeding these insights...... in influencing technological change. In developing countries, technology assessment has received relatively little attention, but recent developments have expressed a ‘call-to-arms’ to tailor flexible approaches by ensuring the involvement of diverse stakeholders and citizens and continual learning among......An old piece of conventional wisdom warns against unsustainable ‘white elephants’ in any attempts at international transferal, adoption or development of technologies in developing countries. After more than half a century of failed attempts to introduce technologies in such settings mostly through...

  16. Assessments of emerging science and technologies: Mapping the landscape

    NARCIS (Netherlands)

    Forsberg, E.M.; Thorstensen, E.; Nielsen, R.O.; Bakker, de E.

    2014-01-01

    This paper presents comparative work from the EST-Frame project on technology appraisal. It focuses on studies of 'advisory domains' (more or less distinct traditions for assessment of technologies, such as risk analysis, foresight and ethical assessments). The purpose of the study was to increase t

  17. Principles of sustainability science to assess alternative energy technologies

    CSIR Research Space (South Africa)

    Brent, AC

    2009-04-01

    Full Text Available , adaptive capacity, and complexity of social-ecological systems to assess the potential of such technologies for increasing the carrying capacity and improving the resilience of social-ecological systems, or to assess the resilience of the technological...

  18. Technology assessment of PACS in Osaka University Hospital.

    Science.gov (United States)

    Inamura, K; Satoh, K; Kondoh, H; Mori, Y; Kozuka, T

    1994-05-01

    This paper describes a methodology of PACS technology assessment and gives examples of the results of measurement of 24 items of PACS-related situations of image diagnosis systems in Osaka University Hospital before a PACS is installed. These data are to be compared with the data which will be measured after PACS is installed in the new Osaka University Hospital, in order to complete our technology assessment. We propose common variables, units, and conditions of measurement, in order to establish a standard method of data comparison between before and after PACS installation in hospitals at large. We designed our PACS taking technology assessment into account. We do not stop the technology assessment at the efficacy evaluation, because PACS must be more than a tool for radiological practice. We extend the technology assessment into the effectiveness evaluation, so that PACS is a part of radiological practice itself, and diagnostic accuracy, economy and efficiency are the results of PACS operation.

  19. Improving Software Guidance for Technology Readiness Assessments (TRA)

    Science.gov (United States)

    2010-04-29

    Systems & Software Technology Conference Improving Software Guidance for Technology Readiness Assessments (TRA) 29 April 2010 Mike Nicol...APR 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Improving Software Guidance for Technology Readiness...Presented at the 22nd Systems and Software Technology Conference (SSTC), 26-29 April 2010, Salt Lake City, UT. 14. ABSTRACT 15. SUBJECT TERMS

  20. Assessing climate change mitigation technology interventions by international institutions

    DEFF Research Database (Denmark)

    de Coninck, Heleen; Puig, Daniel

    2015-01-01

    Accelerating the international use of climate mitigation technologies is key if effortsto curb climate change are to succeed, especially in developing countries, where weakdomestic technological innovation systems constrain the uptake of climate change mitigationtechnologies. Several...... intergovernmental agencies have set up specific programmes to supportthe diffusion of climate mitigation technologies. Using a simplified technological innovationsystem-based framework, this paper aims to systematically review these programmes, with thedual aim of assessing their collective success in promoting...

  1. Assessment of technology generating institutions in biotechnology ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-05-18

    May 18, 2009 ... biotechnology innovation system of South-Eastern. Nigeria. E. N. Ajani, M. C. ... Agricultural biotechnology provides new technological tools and aims to ..... constraints include poor fringe benefit to researchers ( x. = 2.90) ...

  2. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik

    2008-01-01

    with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances...

  3. Challenges for Information Technology Supporting Educational Assessment

    Science.gov (United States)

    Webb, M.; Gibson, D.; Forkosh-Baruch, A.

    2013-01-01

    This article examines the scope for IT-enabled assessments to serve simultaneously both learners and the enterprise of education. The article proposes ways of combining frameworks that come from two different perspectives: 1) a conceptual approach to assessment design for computerized assessment based on evidence-centred design (ECD) and 2) a…

  4. Review on early technology assessments of nanotechnologies in oncology.

    Science.gov (United States)

    Retèl, Valesca P; Hummel, Marjan J M; van Harten, Wim H

    2009-12-01

    Nanotechnology is expected to play an increasingly important role in the diagnostics, prognostics, and management of targeted cancer treatments. While papers have described promising results for nanotechnology in experimental settings, the translation of fundamental research into clinical applications has yet to be widely adopted. In future, policy makers will need to anticipate new developments for clinical implementation and introduce technology assessments. Here we present an overview of the literature on the technology assessments that have already been undertaken on early stage nanotechnology in cancer care, with particular emphasis placed on clinical efficacy, efficiency, logistics, patient-related features and technology dynamics. Owing to the current stage of development of most nanotechnologies, we found only a limited number of publications describing the application of either Health Technology Assessment (HTA) or Constructive Technology Assessment (CTA). In spite of the promising conclusions of most papers concerning the benefits of clinical implementation, actual clinically relevant applications were rarely encountered, and so far only a few publications report application of systematic forms of technology assessment. Most articles consider aspects of environmental safety, regulation and ethics, often mentioning the need to investigate such issues more thoroughly. Evaluation of financial and organizational aspects is often missing. In order to obtain a realistic perspective on the translation and implementation process there is a need for a broad and systematic evaluation of nanotechnologies at early stages of development. Assessment methods taking technology dynamics into account, such as Constructive Technology Assessment (CTA) should be considered for evaluation purposes.

  5. The Contribution of Health Technology Assessment, Health Needs Assessment, and Health Impact Assessment to the Assessment and Translation of Technologies in the Field of Public Health Genomics

    DEFF Research Database (Denmark)

    Rosenkotter, N.; Vondeling, H.; Blancquaert, I.

    2011-01-01

    or to identify infrastructural needs. HIA delivers information on the impact of technologies in a wider scope and promotes informed decision making. HTA, HNA and HIA provide a partly overlapping and partly unique set of methodologies and infrastructure for the translation and assessment of genomic health...... into the impact on public health and health care practice of those technologies that are actually introduced. This paper aims to give an overview of the major assessment instruments in public health [ health technology assessment (HTA), health needs assessment (HNA) and health impact assessment (HIA)] which could......The European Union has named genomics as one of the promising research fields for the development of new health technologies. Major concerns with regard to these fields are, on the one hand, the rather slow and limited translation of new knowledge and, on the other hand, missing insights...

  6. New Modes of Constructive Technology Assessment for Developing Countries

    DEFF Research Database (Denmark)

    Christensen, David; Remmen, Arne

    by a product or process in a developing country. On the other hand are those who design, develop and promote the technological solution. If the latter group is to follow the call for proactively taking in socio-cultural and user knowledge, what methods may be employed? This paper revisits the literature....... Technology assessment helps assess the potential positive or negative impacts following in the wake of introducing a new technology of any conceivable type. It has an overall philosophy of reducing the cost of learning in society’s handling of new technologies, anticipating impacts and feeding these insights...... universities, NGO’s, firms and users/citizens. In addressing this ‘call-to-arms’, this paper: ‐ Identifies how technology assessment principles may be brought into new decision-making arenas outside of its traditional application area of e.g. parliamentary governance systems. R evisits the technology...

  7. Rail-to-rail low-power fully differential OTA utilizing adaptive biasing and partial feedback

    DEFF Research Database (Denmark)

    Tuan Vu, Cao; Wisland, Dag T.; Lande, Tor Sverre

    A fully differential rail-to-rail Operational Transconductance Amplifier (OTA) with improved DC-gain and reduced power consumption is proposed in this paper. By using the adaptive biasing circuit and two differential inputs, a low stand-by current can be obtained together with reduced power consu...

  8. Low Noise Low Power CMOS Telescopic-OTA for Bio-Medical Applications

    Directory of Open Access Journals (Sweden)

    Bellamkonda Saidulu

    2016-10-01

    Full Text Available The preamplifier block is crucial in bio-medical signal processing. The power intensive Operational Transconductance Amplifier (OTA is considered, and the performance of preamplifier is studied. A low noise and low power telescopic OTA is proposed in this work. To reduce the noise contribution in the active load transistors, source degeneration technique is incorporated in the current stealing branch of the OTA. The OTA design optimization is achieved by g m / I d methodology, which helps to determine the device geometrical parameters (W/L ratio. The proposed design was implemented in CMOS 90 nm with bias current and supply voltage of 1.6 µA and 1.2 V, respectively. The post layout simulation results of the proposed amplifier gave a gain of 62 dB with phase margin 57°, CMRR 78 dB, input referred noise 3.2 µVrms, Noise Efficiency Factor (NEF 1.86 and power consumption of 1.92 µW.

  9. Systematic Design and Modeling of a OTA-C Filter for Portable ECG Detection.

    Science.gov (United States)

    Shuenn-Yuh Lee; Chih-Jen Cheng

    2009-02-01

    This study presents a systematic design of the fully differential operational transconductance amplifier-C (OTA-C) filter for a heart activities detection apparatus. Since the linearity and noise of the filter is dependent on the building cell, a precise behavioral model for the real OTA circuit is created. To reduce the influence of coefficient sensitivity and maintain an undistorted biosignal, a fifth-order ladder-type lowpass Butterworth is employed. Based on this topology, a chip fabricated in a 0.18- mum CMOS process is simulated and measured to validate the system estimation. Since the battery life and the integration with the low-voltage digital processor are the most critical requirement for the portable diagnosis device, the OTA-based circuit is operated in the subthreshold region to save power under the supply voltage of 1V. Measurement results show that this low-voltage and low-power filter possesses the HD3 of -48.9 dB, dynamic range (DR) of 50 dB, and power consumption of 453 nW. Therefore, the OTA-C filter can be adopted to eliminate the out-of-band interference of the electrocardiogram (ECG) whose signal bandwidth is located within 250 Hz.

  10. On Probe Weighting for MIMO OTA testing in Anechoic Chamber Setups

    DEFF Research Database (Denmark)

    Fan, Wei; Kyösti, Pekka; Nuutinen, Jukka-Pekka

    2015-01-01

    The multi-probe anechoic chamber method is promising for OTA testing. The reason can be attributed to its potential for enabling evaluating MIMO terminals in realistic environments. The focus of the paper is on investigating how to create desired spatial channel models with the multi-probe anecho...

  11. A Technology Assessment of Personal Computers. Vol. II: Personal Computer Technology, Users, and Uses.

    Science.gov (United States)

    Nilles, Jack M.

    This volume reports on the initial phase of a technology assessment of personal computers. First, technological developments that will influence the rate of diffusion of personal computer technology among the general populace are examined. Then the probable market for personal computers is estimated and analyzed on a functional basis, segregating…

  12. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-01

    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  13. LNG vehicle technology, economics, and safety assessment

    Science.gov (United States)

    Powars, Charles A.; Moyer, Carl B.; Lowell, Douglas D.

    1994-02-01

    Liquid natural gas (LNG) is an attractive transportation fuel because of its high heating value and energy density (i.e., Btu/lb. and Btu/gal.), clean burning characteristics, relatively low cost ($/Btu), and domestic availability. This research evaluated LNG vehicle and refueling system technology, economics, and safety. Prior and current LNG vehicle projects were studied to identify needed technology improvements. Life-cycle cost analyses considered various LNG vehicle and fuel supply options. Safety records, standards, and analysis methods were reviewed. The LNG market niche is centrally fueled heavy-duty fleet vehicles with high fuel consumption. For these applications, fuel cost savings can amortize equipment capital costs.

  14. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  15. 20 Years of Technology and Language Assessment in "Language Learning & Technology"

    Science.gov (United States)

    Chapelle, Carol A.; Voss, Erik

    2016-01-01

    This review article provides an analysis of the research from the last two decades on the theme of technology and second language assessment. Based on an examination of the assessment scholarship published in "Language Learning & Technology" since its launch in 1997, we analyzed the review articles, research articles, book reviews,…

  16. 20 Years of Technology and Language Assessment in "Language Learning & Technology"

    Science.gov (United States)

    Chapelle, Carol A.; Voss, Erik

    2016-01-01

    This review article provides an analysis of the research from the last two decades on the theme of technology and second language assessment. Based on an examination of the assessment scholarship published in "Language Learning & Technology" since its launch in 1997, we analyzed the review articles, research articles, book reviews,…

  17. Superconducting Technology Assessment (NSA, Office of Corporate Assessments)

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — The government, and particularly NSA, has a continuing need for ever-increasing computational power. The Agency is concerned about projected limitations of...

  18. Technology assessments in transportation: survey of recent literature

    Energy Technology Data Exchange (ETDEWEB)

    LaBelle, S.J.

    1980-03-01

    A survey and an evaluation of recent studies of transportation systems done in a technology-assessment framework were undertaken as the basis for a detailed statement of work for a US Department of Energy technology assessment of transportation energy-conservation strategies. Several bibliographies were searched and numerous professionals in the field of technology assessment were contacted regarding current work. Detailed abstracts were prepared for studies judged to be sufficiently broad in coverage of impacts assessed, yet detailed in coverage of all or part of the nation's transportation systems. Some studies were rich in data but not comprehensive in their analytical approach; brief abstracts were prepared for these. An explanation of the criteria used to screen the studies, as well as abstracts of 37 reports, are provided in this compendium of transportation-technology-assessment literature.

  19. Fostering and Assessing Creativity in Technology Education

    Science.gov (United States)

    Buelin-Biesecker, Jennifer Katherine

    2012-01-01

    This study compared the creative outcomes in student work resulting from two pedagogical approaches to creative problem solving activities. A secondary goal was to validate the Consensual Assessment Technique (CAT) as a means of assessing creativity. Linear models for problem solving and design processes serve as the current paradigm in classroom…

  20. Assessment of Technology for Information Services Planning

    Science.gov (United States)

    1979-08-01

    organi- zation, and external services (external timesharing and turnkey computer systems). Areas of impact are specific to the organization. The...timesharing vendors, changing services turnkey systems - potential and problems impacts and trends o distributed data processing technology needed...includes credit cards, automobile loans, personal and real estate loans, and leasing . Service improvements would aim at expediting credit review, payment

  1. Using technology in assessing integrated science and mathematics learning

    Science.gov (United States)

    Berlin, Donna F.; White, Arthur L.

    1995-03-01

    Drawing from current models, research, and science and mathematics education reform documents, this article first defines and/or delimits three broad domains of education: integrated school science and mathematics, assessment, and technology. Based upon this three-tiered discussion, a list of characteristics is then distilled to guide in the development of assessment for integrated school science and mathematics using technology. Two integrated school science and mathematics activities are provided to illustrate the alignment of instruction and assessment and the systematic integration of technology into both.

  2. Systems Engineering Technology Readiness Assessment of Hybrid-Electric Technologies for Tactical Wheeled Vehicles

    Science.gov (United States)

    2014-09-01

    Department of Energy. 2007. Energy Efficiency and Renewable Energy. “Freedom CAR and vehicle technology program; Plug-In hybrid- electric vehicle R&D Plan...ENGINEERING TECHNOLOGY READINESS ASSESSMENT OF HYBRID- ELECTRIC TECHNOLOGIES FOR TACTICAL WHEELED VEHICLES by Eddie E. McCown September 2014 Thesis...HYBRID- ELECTRIC TECHNOLOGIES FOR TACTICAL WHEELED VEHICLES 5. FUNDING NUMBERS 6. AUTHOR(S) Eddie E. McCown 7. PERFORMING ORGANIZATION NAME(S) AND

  3. Study of gene expression and OTA production by Penicillium nordicum during a small-scale seasoning process of salami.

    Science.gov (United States)

    Ferrara, Massimo; Magistà, Donato; Epifani, Filomena; Cervellieri, Salvatore; Lippolis, Vincenzo; Gallo, Antonia; Perrone, Giancarlo; Susca, Antonia

    2016-06-16

    Penicillium nordicum, an important and consistent producer of ochratoxin A (OTA), is a widely distributed contaminant of protein rich food with elevated NaCl. It is usually found on dry-cured meat products and is considered the main species responsible for their contamination by OTA. The aim of this work was to study the gene expression of a polyketide synthase (otapksPN) involved in P. nordicum OTA biosynthesis, and OTA production during a small-scale seasoning process. Fresh pork sausages were surface inoculated with P. nordicum and seasoned for 30days. Gene expression and OTA production were monitored throughout the seasoning process after 4, 5, 6, 7, 10, 14, and 30days. The expression of otapksPN gene was already detected after 4days and increased significantly after 7days of seasoning, reaching the maximum expression level after 10days (1.69×10(4)copies/100mg). Consistently with gene expression monitoring, OTA was detected from the 4th day and its content increased significantly from the 7th day, reaching the maximum level after 10days. In the late stages of the seasoning process, OTA did not increase further and the number of gene copies was progressively reduced after 14 and 30days.

  4. Aspergillus steynii and Aspergillus westerdijkiae as potential risk of OTA contamination in food products in warm climates.

    Science.gov (United States)

    Gil-Serna, Jessica; Patiño, Belén; Cortes, Laura; Gonzalez-Jaen, Maria Teresa; Vazquez, Covadonga

    2015-04-01

    Aspergillus steynii and Aspergillus westerdijkiae are the main ochratoxin A (OTA) producing species of Aspergillus section Circumdati. Due to its recent description, few data are available about the influence of ecophysiological factors on their growth and OTA production profiles. In this work, the effect of temperature (20, 24 and 28 °C) and water activity (aw) (0.928, 0.964 and 0.995) on growth, sporulation and OTA production by these fungi was examined in CYA and media prepared from paprika, green coffee, anise, grapes, maize and barley. Growth was positively affected by the highest temperature and aw values indicating that both species might be expected in warm climates or storage conditions. However, optimal growth conditions showed differences depending on the medium. OTA production was markedly affected by substrate and showed qualitative and quantitative differences. Both species, especially A. steynii, represent a great potential risk of OTA contamination due to their high production in a variety of conditions and substrates, in particular in barley and paprika-based media. Additionally, neither growth nor sporulation did result good indicators of OTA production by A. steynii or A. westerdijkiae; therefore, specific and highly-sensitive detection methods become essential tools for control strategies to reduce OTA risk by these species.

  5. The conceptual and practical challenges to technology categorisation in the preparation of technology needs assessments

    DEFF Research Database (Denmark)

    Nygaard, Ivan; Hansen, Ulrich Elmer

    2015-01-01

    The strong focus in climate negotiations on the transfer and diffusion of technologies as ameans to mitigate and adapt to climate change has entailed various programs to promote the transfer and diffusion of climate technologies, including the Technology Needs Assessment project (TNA). Despite...... a framework for categorizing technologies according to the types of markets and non-markets in which they are diffused. While the framework has contributed to a higher degree of ‘market literacy’ among national stakeholders, four challenges in categorizing technologies have been identified: i) technologies...

  6. History of the international societies in health technology assessment: International Society for Technology Assessment in Health Care and Health Technology Assessment International.

    Science.gov (United States)

    Banta, David; Jonsson, Egon; Childs, Paul

    2009-07-01

    The International Society for Technology Assessment in Health Care (ISTAHC) was formed in 1985. It grew out of the increasing awareness of the international dimensions of health technology assessment (HTA) and the need for new communication methods at the international level. The main function of ISTAHC was to present an annual conference, which gradually grew in size, and also to generally improve in quality from to year. ISTAHC overextended itself financially early in the first decade of the 2000s and had to cease its existence. A new society, Health Technology Assessment international (HTAi), based on many of the same ideas and people, grew up beginning in the year 2003. The two societies have played a large role in making the field of HTA visible to people around the world and providing a forum for discussion on the methods and role of HTA.

  7. Technologies Assessing Limb Bradykinesia in Parkinson’s Disease

    Science.gov (United States)

    Hasan, Hasan; Athauda, Dilan S.; Foltynie, Thomas; Noyce, Alastair J.

    2017-01-01

    Background: The MDS-UPDRS (Movement Disorders Society – Unified Parkinson’s Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. Objective: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016. Methods: A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016. Results: 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase. Conclusion: Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development. PMID:28222539

  8. IMPROVING HOSPITAL LOGISTICS BY RETHINKING TECHNOLOGY ASSESSMENT

    DEFF Research Database (Denmark)

    Jacobsen, Peter; Jørgensen, Pelle Morten Thomas

    2011-01-01

    In order to cope with the future challenges of the health care sector, there is an urging need for improving efficiency at hospitals. The study presents a framework enabling health care managers of improving the in-house logistics. The distinctiveness of the framework is the way in which it relates...... technology, logistics, structure and procedures to efficiency. Changing one factor e.g. technology, initiates an iterative loop focusing on change in the related factors in order to obtain the optimal efficiency. The search for an optimal efficient solution is the driving force of the framework...... at a Danish hospital. The framework is tested on the blood sample logistics between the emergency department and laboratory with the goal of enhancing the efficiency of the emergency department....

  9. Defining the "proven technology" technical criterion in the reactor technology assessment for Malaysia's nuclear power program

    Science.gov (United States)

    Anuar, Nuraslinda; Kahar, Wan Shakirah Wan Abdul; Manan, Jamal Abdul Nasir Abd

    2015-04-01

    Developing countries that are considering the deployment of nuclear power plants (NPPs) in the near future need to perform reactor technology assessment (RTA) in order to select the most suitable reactor design. The International Atomic Energy Agency (IAEA) reported in the Common User Considerations (CUC) document that "proven technology" is one of the most important technical criteria for newcomer countries in performing the RTA. The qualitative description of five desired features for "proven technology" is relatively broad and only provides a general guideline to its characterization. This paper proposes a methodology to define the "proven technology" term according to a specific country's requirements using a three-stage evaluation process. The first evaluation stage screens the available technologies in the market against a predefined minimum Technology Readiness Level (TRL) derived as a condition based on national needs and policy objectives. The result is a list of technology options, which are then assessed in the second evaluation stage against quantitative definitions of CUC desired features for proven technology. The potential technology candidates produced from this evaluation is further narrowed down to obtain a list of proven technology candidates by assessing them against selected risk criteria and the established maximum allowable total score using a scoring matrix. The outcome of this methodology is the proven technology candidates selected using an accurate definition of "proven technology" that fulfills the policy objectives, national needs and risk, and country-specific CUC desired features of the country that performs this assessment. A simplified assessment for Malaysia is carried out to demonstrate and suggest the use of the proposed methodology. In this exercise, ABWR, AP1000, APR1400 and EPR designs assumed the top-ranks of proven technology candidates according to Malaysia's definition of "proven technology".

  10. Illustrating anticipatory life cycle assessment for emerging photovoltaic technologies.

    Science.gov (United States)

    Wender, Ben A; Foley, Rider W; Prado-Lopez, Valentina; Ravikumar, Dwarakanath; Eisenberg, Daniel A; Hottle, Troy A; Sadowski, Jathan; Flanagan, William P; Fisher, Angela; Laurin, Lise; Bates, Matthew E; Linkov, Igor; Seager, Thomas P; Fraser, Matthew P; Guston, David H

    2014-09-16

    Current research policy and strategy documents recommend applying life cycle assessment (LCA) early in research and development (R&D) to guide emerging technologies toward decreased environmental burden. However, existing LCA practices are ill-suited to support these recommendations. Barriers related to data availability, rapid technology change, and isolation of environmental from technical research inhibit application of LCA to developing technologies. Overcoming these challenges requires methodological advances that help identify environmental opportunities prior to large R&D investments. Such an anticipatory approach to LCA requires synthesis of social, environmental, and technical knowledge beyond the capabilities of current practices. This paper introduces a novel framework for anticipatory LCA that incorporates technology forecasting, risk research, social engagement, and comparative impact assessment, then applies this framework to photovoltaic (PV) technologies. These examples illustrate the potential for anticipatory LCA to prioritize research questions and help guide environmentally responsible innovation of emerging technologies.

  11. Quadrennial Technology Review 2015: Technology Assessments--Wind Power

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-10-07

    Wind power has become a mainstream power source in the U.S. electricity portfolio, supplying 4.9% of the nation’s electricity demand in 2014. With more than 65 GW installed across 39 states at the end of 2014, utility-scale wind power is a cost-effective source of low-emissions power generation throughout much of the nation. The United States has significant sustainable land-based and offshore wind resource potential, greater than 10 times current total U.S. electricity consumption. A technical wind resource assessment conducted by the Department of Energy (DOE) in 2009 estimated that the land-based wind energy potential for the contiguous United States is equivalent to 10,500 GW capacity at 80 meters (m) hub and 12,000 GW capacity at 100 meters (m) hub heights, assuming a capacity factor of at least 30%. A subsequent 2010 DOE report estimated the technical offshore wind energy potential to be 4,150 GW. The estimate was calculated from the total offshore area within 50 nautical miles of shore in areas where average annual wind speeds are at least 7 m per second at a hub height of 90 m.

  12. Generating technology assessment. Phase I work plan, Task 1 report

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-15

    A plan of work outlining information to assess electric generating technologies is presented. Projections are made of realistic and understandable engineering and cost assessments of nonnuclear electrical generating technologies. A computer-based method of producing such engineering and cost estimates for use by EIA's Coal and Electric Power Analysis Division is to be developed and implemented. Technologies and processes to be assessed are: all nonnuclear conventional and nonconventional (coal gasification, advanced combustion turbines, atmospheric fluidized bed combustion, fuel cells, geothermal, solar thermal and photovoltaics, biomass conversion to electricity, ocean thermal, wind, and MHD). Engineering specifications recommended for determination are listed. Compatibility of the technologies are to be assessed with EIA models: MEFS, LEAP, and NCM.

  13. Instruments for Assessing the Impact of Technology in Education

    Science.gov (United States)

    Christensen, Rhonda; Knezek, Gerald

    2002-01-01

    Ten years of instrument development are summarized and placed within a framework for assessing the impact of technology in education. Seven well-validated instruments spanning the areas of attitudes, beliefs, skills, competencies, and technology integration proficiencies are presented, along with data analysis examples. These instruments are…

  14. Lifecycle Assessment of Biofuel Production from Wood Pyrolysis Technology

    Science.gov (United States)

    Manyele, S. V.

    2007-01-01

    Due to a stronger dependency on biomass for energy, there is a need for improved technologies in biomass-to-energy conversion in Tanzania. This paper presents a life cycle assessment (LCA) of pyrolysis technology used for conversion of wood and wood waste to liquid biofuel. In particular, a survey of environmental impacts of the process is…

  15. Scenario drafting to anticipate future developments in technology assessment

    NARCIS (Netherlands)

    Retel, V.P.; Joore, M.A.; Rutgers, E.J.; Harten, van W.H.

    2012-01-01

    Background Health Technology Assessment (HTA) information, and in particular cost-effectiveness data is needed to guide decisions, preferably already in early stages of technological development. However, at that moment there is usually a high degree of uncertainty, because evidence is limited and d

  16. Technology needs assessment (TNA) resource document for South Africa

    CSIR Research Space (South Africa)

    Taviv, R

    2007-08-01

    Full Text Available TNA(Technology needs assessment) is a requirement of Article 4.5 of the UNFCCC ‘Technology Transfer’ is a broad set of processes covering the flows of know-how, experience and equipment for mitigating or adapting to climate change amongst different...

  17. Lifecycle Assessment of Biofuel Production from Wood Pyrolysis Technology

    Science.gov (United States)

    Manyele, S. V.

    2007-01-01

    Due to a stronger dependency on biomass for energy, there is a need for improved technologies in biomass-to-energy conversion in Tanzania. This paper presents a life cycle assessment (LCA) of pyrolysis technology used for conversion of wood and wood waste to liquid biofuel. In particular, a survey of environmental impacts of the process is…

  18. Teacher Learning of Technology-Enhanced Formative Assessment

    Science.gov (United States)

    Beatty, Ian D.; Feldman, Allan; Leonard, William J.; Gerace, William J.; St. Cyr, Karen; Lee, Hyunju; Harris, Robby

    2008-01-01

    "Technology-Enhanced Formative Assessment" (TEFA) is an innovative pedagogy for teaching secondary school science or mathematics with "classroom response system" technology. "Teacher Learning of TEFA" (TLT) is a five year research project studying teacher change in the context of an intensive, sustained, on-site professional development (PD)…

  19. New Technologies for Standoff Assessment of Radiological Contamination

    Energy Technology Data Exchange (ETDEWEB)

    Cherepy, N; Stevens, C; Wurtz, R; Sanner, R; Frank, M; Tillotson, T; Hrubesh, L; Dietrich, D; Dignon, J; Soufli, R

    2005-05-06

    Technologies to rapidly quantify surface activity with minimal worker contact would dramatically decrease the radiation dose a radiation worker receives in assessment and cleanup operations, while obtaining a clear image of exactly where dispersed contamination is located. LLNL efforts in the development of the Photochromic Radiation Dosimeter and the Imaging Assessment System will be described. Initial use of these technologies in decontamination and decommissioning of contaminated facilities demonstrates several significant advantages over standard techniques such as survey meters and swipes.

  20. Technologies for Assessing Behavioral and Cognitive Markers of Suicide Risk

    Science.gov (United States)

    2016-10-01

    AWARD NUMBER: W81XWH-15-1-0632 TITLE: Technologies for Assessing Behavioral and Cognitive Markers of Suicide Risk PRINCIPAL INVESTIGATOR: Brian...CONTRACT NUMBER Technologies for Assessing Behavioral and Cognitive Markers of Suicide Risk 5b. GRANT NUMBER W81XWH-15-1-0632 5c. PROGRAM ELEMENT...suicide risk and to evaluate the predictive utility of these markers over a one year period. We propose to achieve these aims by: (a) collecting

  1. Potential Technologies for Assessing Risk Associated with a Mesoscale Forecast

    Science.gov (United States)

    2015-10-01

    the actual model-forecast error—the 500-hPa root-mean-square error (RMSE) height error. Future work should also consider other forecast metrics such...ARL-TN-0708 ● OCT 2015 US Army Research Laboratory Potential Technologies for Assessing Risk Associated with a Mesoscale...OCT 2015 US Army Research Laboratory Potential Technologies for Assessing Risk Associated with a Mesoscale Forecast by Patrick A

  2. Technology assessment of geothermal energy resource development

    Energy Technology Data Exchange (ETDEWEB)

    1975-04-15

    Geothermal state-of-the-art is described including geothermal resources, technology, and institutional, legal, and environmental considerations. The way geothermal energy may evolve in the United States is described; a series of plausible scenarios and the factors and policies which control the rate of growth of the resource are presented. The potential primary and higher order impacts of geothermal energy are explored, including effects on the economy and society, cities and dwellings, environmental, and on institutions affected by it. Numerical and methodological detail is included in appendices. (MHR)

  3. Gender and risk assessment in contraceptive technologies

    NARCIS (Netherlands)

    Kammen, van Jessika; Oudshoorn, Nelly

    2002-01-01

    This paper concerns a comparison of risk assessment practices of contraceptives for women and men. Our analysis shows how the evaluation of health risks of contraceptives does not simply reflect the specific effects of chemical compounds in the human body. Rather, we show how side-effects were rated

  4. Technology assessment for Spaceship Two, space tourism, and private spaceflight

    Science.gov (United States)

    Hancock, Randy

    A seven-step technology assessment was conducted to address questions regarding the significance and likely consequences associated with the introduction of Spaceship Two, space tourism, and private spaceflight. Impacts were assessed across four categories: the Role and Functions of Government, Private Industry Factors, Cultural and Societal Impacts, and the Time Frame in which these impacts were anticipated to occur. The technology assessment findings were compared to the results of expert interviews that addressed the sane four categories. The researcher noted that, while there was overwhelming agreement between the technology assessment's primary impacts and the expert interview responses, there were several differences. The technology assessment and interviewees agreed that the federal government would likely be both a regulator and user of private spaceflight. Both agreed that business partnerships would be key in pursuing private spaceflight. There was also consensus that, as market forces come to bear, ticket prices would drop and a larger market and broader passenger demographic would emerge. The technology assessment and experts agreed that an accident, especially one early in the industry's evolution, could be disastrous. Both agreed that private spaceflight can serve as a inspiration to students and be a positive influence in society, and both agreed that the start of passenger flights should take place in the 2010 - 2012 timeframe. Due to the potentially disastrous consequences of an accident, there was agreement between the technology assessment and experts on the value of flight and ground crew training, driven by insurance carriers and federal mandate. Most differences between the technology assessment's findings and the expert interview responses were due to omission, rather than direct disagreement. However, this was not the case in every instance. The most significant difference between the technology assessment and the experts involved the

  5. Problems of method of technology assessment. A methodological analysis; Methodenprobleme des Technology Assessment; Eine methodologische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, V.

    1993-03-01

    The study undertakes to analyse the theoretical and methodological structure of Technology Assessment (TA). It is based on a survey of TA studies which provided an important condition for theoreticall sound statements on methodological aspects of TA. It was established that the main basic theoretical problems of TA are in the field of dealing with complexity. This is also apparent in the constitution of problems, the most elementary and central approach of TA. Scientifically founded constitution of problems and the corresponding construction of models call for interdisciplinary scientific work. Interdisciplinarity in the TA research process is achieved at the level of virtual networks, these networks being composed of individuals suited to teamwork. The emerging network structures have an objective-organizational and an ideational basis. The objective-organizational basis is mainly the result of team composition and the external affiliations of the team members. The ideational basis of the virtual network is represented by the team members` mode of thinking, which is individually located at a multidisciplinary level. The theoretical `skeleton` of the TA knowledge system, which is represented by process knowledge based linkage structures, can be generated and also processed in connection with the knowledge on types of problems, areas of analysis and procedures to deal with complexity. Within this process, disciplinary knowledge is a necessary but not a sufficient condition. Metatheoretical and metadisciplinary knowledge and the correspondingly processes complexity of models are the basis for the necessary methodological awareness, that allows TA to become designable as a research procedure. (orig./HP) [Deutsch] Die Studie stellt sich die Aufgabe, die theoretische und methodische Struktur des Technology Assessment (TA) zu analysieren. Sie fusst auf Erhebungen, die bei Technology-Assessment-Studien vorgenommen wurden und die wesentliche Voraussetzungen fuer

  6. Measuring and Assessing Application-Specific Technology Readiness

    Directory of Open Access Journals (Sweden)

    Antonino Ardilio

    2015-11-01

    Full Text Available Technology readiness is a crucial issue for decision-makers in technology-driven enterprises, determining whether the technology will or won’t be adopted for use in products or as a process technology. We know that, in some cases, lower technology readiness will be accepted by the users; these could be end-users, but, more often, it will be used in companies. The impact of a too early or too late adopted technology can be huge for companies and can even threaten market position or the existence of the company itself. Research institutes and technology developers, in particular application-oriented research organizations, might be also interested in which parameters or technology attributes should be improved or extended, according to the addressed application field, so that the technology fulfils the market-requested functions and a fast diffusion in the market can be achieved. Existing technology readiness models cover the various usages of the technology. In many cases, they assess the technology’s use in across different industries and application fields. However, the requirements in many fields are mostly different and very specific; thus, evaluation at such a high level can’t conclude whether the technology should be considered and adopted in the applications involved. This paper introduces an approach on how to determine and map the application-specific readiness of technology by decomposing both the application and the technology into its requested functions, as well as dynamically mapping the individual technology performance criteria. The applicability of this model will be demonstrated and discussed by a use case in the area of OLED-technology.

  7. Space-reactor electric systems: subsystem technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R.V.; Bost, D.; Determan, W.R.

    1983-03-29

    This report documents the subsystem technology assessment. For the purpose of this report, five subsystems were defined for a space reactor electric system, and the report is organized around these subsystems: reactor; shielding; primary heat transport; power conversion and processing; and heat rejection. The purpose of the assessment was to determine the current technology status and the technology potentials for different types of the five subsystems. The cost and schedule needed to develop these potentials were estimated, and sets of development-compatible subsystems were identified.

  8. Assessment of Wearable Sensor Technologies for Biosurveillance

    Science.gov (United States)

    2014-11-01

    intelligence (AI) and biometric data, the device captures electrodermal activity in real time to assess emotional states. Using the technique of...Biometric smartwear Hexoskin Breathing rate, volume, cadence, ECG, sleep position, heart rate, and other physiological data Wearable Wellnes...watches. Google Fit’s fitness tracking will display data such as heart rate, or detect whether its wearer has been physically active . Google’s

  9. Phase shifter technology assessment - Prospects and applications

    Science.gov (United States)

    Sokolov, Vladimir

    1991-01-01

    Capabilities and limitations of MMIC phase shifter technology at microwave and millimeter wave frequencies are reviewed. MMIC-based phase arrays make it possible to integrate active elements at the array face, i.e., to incorporate transmit power amplifiers and/or low noise amplifiers at each antenna element. Active elements make it possible to increase power efficiency and reliability and provide graceful degradation. Monolithic integration of the various transmit/receive functions including phase shifting is considered to be feasible through at least the lower millimeter-wave frequency range (about 30-100 GHz). MMIC integration also allows more flexibility in array design including those that are intended for airborne conformal applications.

  10. The conceptual and practical challenges to technology categorisation in the preparation of technology needs assessments

    DEFF Research Database (Denmark)

    Nygaard, Ivan; Hansen, Ulrich Elmer

    2015-01-01

    The strong focus in climate negotiations on the transfer and diffusion of technologies as ameans to mitigate and adapt to climate change has entailed various programs to promote the transfer and diffusion of climate technologies, including the Technology Needs Assessment project (TNA). Despite...... for the challenges in formulating plans of actions for technologies. If, due to a lack of conceptual clarity, it is not clear to countries whether the diffusion of a specific technology should be implemented by a project or by means of an enabling framework, the measures proposed in the action plans may...

  11. Noninvasive imaging technologies for cutaneous wound assessment: A review.

    Science.gov (United States)

    Paul, Dereck W; Ghassemi, Pejhman; Ramella-Roman, Jessica C; Prindeze, Nicholas J; Moffatt, Lauren T; Alkhalil, Abdulnaser; Shupp, Jeffrey W

    2015-01-01

    The ability to phenotype wounds for the purposes of assessing severity, healing potential and treatment is an important function of evidence-based medicine. A variety of optical technologies are currently in development for noninvasive wound assessment. To varying extents, these optical technologies have the potential to supplement traditional clinical wound evaluation and research, by providing detailed information regarding skin components imperceptible to visual inspection. These assessments are achieved through quantitative optical analysis of tissue characteristics including blood flow, collagen remodeling, hemoglobin content, inflammation, temperature, vascular structure, and water content. Technologies that have, to this date, been applied to wound assessment include: near infrared imaging, thermal imaging, optical coherence tomography, orthogonal polarization spectral imaging, fluorescence imaging, laser Doppler imaging, microscopy, spatial frequency domain imaging, photoacoustic detection, and spectral/hyperspectral imaging. We present a review of the technologies in use or development for these purposes with three aims: (1) providing basic explanations of imaging technology concepts, (2) reviewing the wound imaging literature, and (3) providing insight into areas for further application and exploration. Noninvasive imaging is a promising advancement in wound assessment and all technologies require further validation.

  12. Elaboration and validation of an assistive technology assessment questionnaire

    Directory of Open Access Journals (Sweden)

    Fernanda Jorge Guimarães

    2015-06-01

    Full Text Available Assistive Technologies consists of resources, methods, and strategies favoring autonomy and inclusion of elderly and people with disabilities, being scarce in the literature instruments assessing them. A methodology study conducted with a panel of specialists and people with visual impairment, aimed to elaborate and validate a questionnaire to assess educational assistive technology. To consider an item as valid, we used 80% as agreement percentage, and validity and reliability of the questionnaire were calculated. Assistive Technology was characterized in six attributes: objectives, access, clarity, structure and presentation, relevance and efficacy, interactivity, and 19 items were elaborated to compose the questionnaire. From those, 11 obtained percentages higher than 80%, seven were modified and one was excluded. The instrument Cronbach’s alpha was 0,822, guaranteeing validity and reliability of the tool to assess health education Assistive Technology, and therefore, its use is indicated.

  13. Technology Enhanced Formative Assessment for 21st Century Learning

    Science.gov (United States)

    Spector, J. Michael; Ifenthaler, Dirk; Sampson, Demetrios; Yang, Lan; Mukama, Evode; Warusavitarana, Amali; Dona, Kulari Lokuge; Eichhorn, Koos; Fluck, Andrew; Huang, Ronghuai; Bridges, Susan; Lu, Jiingyan; Ren, Youqun; Gui, Xiaoqing; Deneen, Christopher C.; San Diego, Jonathan; Gibson, David C.

    2016-01-01

    This paper is based on the deliberations of the Assessment Working Group at EDUsummIT 2015 in Bangkok, Thailand. All of the members of Thematic Working Group 5 (TWG5) have contributed to this synthesis of potentials, concerns and issues with regard to the role of technology in assessment as, for and of learning in the 21st century. The group…

  14. Utilisation of medical technology assessment in health policy

    NARCIS (Netherlands)

    van den Heuvel, WJA; Wieringh, R; van den Heuvel, LPM

    1997-01-01

    Objective: To assess the contribution of medical technology assessment (MTA) to health policy decision making, the question has to be answered whether MTA is actually being used in decision-making processes and what factors are related to its utilisation. Design: We investigated recent Dutch policy

  15. Voice Assessment of Student Work: Recent Studies and Emerging Technologies

    Science.gov (United States)

    Eckhouse, Barry; Carroll, Rebecca

    2013-01-01

    Although relatively little attention has been given to the voice assessment of student work, at least when compared with more traditional forms of text-based review, the attention it has received strongly points to a promising form of review that has been hampered by the limits of an emerging technology. A fresh review of voice assessment in light…

  16. A Technology Assessment of Personal Computers. Vol. I: Summary.

    Science.gov (United States)

    Nilles, Jack M.

    This volume summarizes the results of a 2-year technology assessment of personal computers. The purpose of this study was to explore possible future modes of growth of the personal computer and related industries, to assess the impacts and consequences of that growth, and to present some of the policy issues and options which may arise as a…

  17. Reactor technology assessment and selection utilizing systems engineering approach

    Science.gov (United States)

    Zolkaffly, Muhammed Zulfakar; Han, Ki-In

    2014-02-01

    The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology.

  18. Emerging frontier technologies for food safety analysis and risk assessment

    Institute of Scientific and Technical Information of China (English)

    DONG Yi-yang; LIU Jia-hui; WANG Sai; CHEN Qi-long; GUO Tian-yang; ZHANG Li-ya; JIN Yong; SU Hai-jia; TAN Tian-wei

    2015-01-01

    Access to security and safe food is a basic human necessity and essential for a sustainable world. To perform hi-end food safety analysis and risk assessment with state of the art technologies is of utmost importance thereof. With applications as exempliifed by microlfuidic immunoassay, aptasensor, direct analysis in real time, high resolution mass spectrometry, benchmark dose and chemical speciifc adjustment factor, this review presents frontier food safety analysis and risk assess-ment technologies, from which both food quality and public health wil beneift undoubtedly in a foreseeable future.

  19. The principles of Health Technology Assessment in laboratory medicine.

    Science.gov (United States)

    Liguori, Giorgio; Belfiore, Patrizia; D'Amora, Maurizio; Liguori, Renato; Plebani, Mario

    2017-01-01

    The Health Technology Assessment (HTA) is a multi-professional and multidisciplinary evaluation approach designed to assess health technology in the broadest sense of the term, from its instruments to the rearranging of its organizational structures. It is by now an established methodology at national and international levels that involves several medical disciplines thanks to its versatility. Laboratory medicine is one of these disciplines. Such specialization was subjected, in recent years, to deep changes even from an organizational standpoint, in order to meet the health needs of the population, making them as effective and cost-effective as possible. In this regard, HTA was the tool used to assess implications in different areas.

  20. Covariance-based Spatial Channel Structure Emulation for MIMO OTA Testing

    DEFF Research Database (Denmark)

    Tsakalaki, Elpiniki; Alrabadi, Osama; Fan, Wei;

    2014-01-01

    The paper presents a general framework for recreating the spatial channel structure in a MIMO over-the-air (OTA) multiprobe anechoic chamber testing setup. The idea is to find the power weights of the spatial taps (antenna probes) that minimize a certain distance between the spatial channel covar...... among the antennas-under-test by considering the whole spatial covariance structure. The simulation results validate the improved performance of the suggested approach in terms of emulation accuracy compared to the key emulation methods proposed in the literature.......The paper presents a general framework for recreating the spatial channel structure in a MIMO over-the-air (OTA) multiprobe anechoic chamber testing setup. The idea is to find the power weights of the spatial taps (antenna probes) that minimize a certain distance between the spatial channel...

  1. Realization of Electronic OTA Amplifiers with Linear and Tunable Transconductance and its Usages in Continuous - Filters

    Directory of Open Access Journals (Sweden)

    Ebrahim Borzabadi

    2012-01-01

    Full Text Available The aim of this paper is the introduction of a CMOS OTA basic block that its transconductance gain can be electronically and linearly tuned. This transconductance is proportional to the square root of the bias current. To achieve the maximum output voltage and create a wide range of linear transconductance the CMOS OTA has been used.Then the variation of the transconductance and its effects on the performance of Continuous-time filters has been considered. The novelty of this paper is to show that how the transconductance of a first-Order filter is transformed to high pass and low pass filters and the transfer function of a second-order filter is transformed into high pass, low pass , band pass and band rejection filters. The performance of the proposed circuit is discussed and confirmed through MATLAB and PSPICE-simulation results.

  2. Treatment of nevus of OTA by Q-switched, frequency doubled, ND: Yag laser

    Directory of Open Access Journals (Sweden)

    National Skin and Hair Care Centre

    2002-01-01

    Full Text Available Nevus of Ota is a dermal melanocytic nevus for which hitherto no effective therapy was available. Lasers have been successfully tried for ablation. But there is no Indian experience till date. Q- Switched, Frequency Doubled, Nd: YAG Laser was installed at our centre an year ago. The first operated case, which has shown near complete pigment dilution, is being presented. The patient underwent three treatments with a minimum of 2 months between sessions. Pre and post therapy photographs were taken and side effects documented. The patient has shown near complete pigment dilution after 3 treatments. Q-Switched, Frequency Doubled, Nd: YAG Laser is effective in treating Nevus of Ota in the Indian skin types. There are no complications noticed till date in our experience.

  3. Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

    Science.gov (United States)

    Vivancos, Ana; Caratú, Ginevra; Matito, Judit; Muñoz, Eva; Ferrer, Berta; Hernández-Losa, Javier; Bodet, Domingo; Pérez-Alea, Mileidys; Cortés, Javier; Garcia-Patos, Vicente; Recio, Juan A

    2016-03-01

    Melanoma presents molecular alterations based on its anatomical location and exposure to environmental factors. Due to its intrinsic genetic heterogeneity, a simple snapshot of a tumor's genetic alterations does not reflect the tumor clonal complexity or specific gene-gene cooperation. Here, we studied the genetic alterations and clonal evolution of a unique patient with a Nevus of Ota that developed into a recurring uveal-like dermal melanoma. The Nevus of Ota and ulterior lesions contained GNAQ mutations were c-KIT positive, and tumors showed an increased RAS pathway activity during progression. Whole-exome sequencing of these lesions revealed the acquisition of BAP1 and TP53 mutations during tumor evolution, thereby unmasking clonal heterogeneity and allowing the identification of cooperating genes within the same tumor. Our results highlight the importance of studying tumor genetic evolution to identify cooperating mechanisms and delineate effective therapies.

  4. On the design of a low-voltage two-stage OTA using bulk-driven and positive feedback techniques

    Science.gov (United States)

    Khameh, Hassan; Shamsi, Hossein

    2012-09-01

    This article presents the design and simulation of a fully differential two-stage operational transconductance amplifier (OTA) in a 0.18 µm CMOS process with a 0.9 V supply voltage. For this purpose, both the bulk-driven and positive feedback techniques are employed. These techniques increase the DC gain by about 18.5 dB without consuming more power and changing the unity-gain bandwidth and phase margin of the OTA.

  5. A low power 14 bit 51.2 kS/s double-sampling extended counting ADC with a class-AB OTA

    Institute of Scientific and Technical Information of China (English)

    Chen Honglei; Wu Dong; Shen Yanzhao; Xu Jun

    2012-01-01

    A 14 bit 51.2 kS/s extended counting analog to digital converter (EC-ADC) is presented.Two techniques are utilized to reduce its power consumption.First,a double-sampling configuration based on a fully-floating bilinear integrator is proposed to reduce the clock frequency.Second,a class-AB operational transconductance amplifier (OTA) is designed to improve the power efficiency.In addition,the chopping technique is used to eliminate the OTA flicker noise effect.The proposed ADC is fabricated in 0.18μm CMOS technology with a core area of 0.04 mm2.At a 51.2 kS/s conversion rate,it achieves a 94 dB SFDR and an 11.6 bit ENOB,while consuming only 77 μW from a 1.8 V power supply.The figure of merit is only 0.48 pJ/step.

  6. A molecular and bioinformatic study on the ochratoxin A (OTA)-producing Aspergillus affinis (section Circumdati).

    Science.gov (United States)

    Davolos, Domenico; Pietrangeli, Biancamaria

    2014-05-01

    Aspergillus affinis (section Circumdati) is a novel ochratoxin A (OTA)-producing species found in submerged riparian decomposing leaves. However, very little is known about its role on the breakdown of plant debris and its ability to degrade carbohydrate polymers. Moreover, its OTA biosynthetic pathway has not yet been explored. In the present paper, we investigated the gene encoding the extracellular alpha-amylase (amyAa) of A. affinis within the evolution of the Aspergillus lineages in relation to the possible use of this enzyme in starch processing. The novel amyAa, despite being related to branches of the Aspergillus species of the sections Terrei and Flavi, formed a distinct phylogenetic branch, which may be of outstanding importance from a biotechnological point of view. Moreover, we identified the polyketide synthase gene (pks) putatively required for the first step of OTA biosynthesis in A. affinis. This otapks was examined in relation to a limited number of orthologous genes available from Aspergillus species of the sections Circumdati and Nigri. Our study highlights the importance of otapks as target genes in the treatment of ochratoxigenic Aspergillus species on a more comprehensive evolutionary basis.

  7. Comparison of acquired bilateral nevus of Ota-like macules in men and women

    Directory of Open Access Journals (Sweden)

    Woo Jin Lee

    2014-01-01

    Full Text Available Background: The clinical and histopathological characteristics of acquired bilateral nevus of Ota-like macules in men are poorly documented due to its rarity. Aims: To compare the clinical and histopathological characteristics of acquired bilateral nevus of Ota-like macules in men with the condition in women. Methods: We studied 11 men and 62 women, all with a clinical diagnosis of acquired bilateral nevus of Ota-like macules. Biopsies were taken from 5 men and 10 women and their clinical and histopathological features were compared. Results: The most frequently affected site in men was the forehead [8 (73% out of 11 patients]. Lesions on the forehead were more common in men than women (P = 0.001. In contrast to women, there was no apparent tendency of the lesions to become more blue with age in men. Concurrent melasma was observed in 14 (23% out of 62 women, but not in men. Extra-facial acquired dermal melanocytosis was noted in 2 (18% out of 11 men and in none of the 62 women. Conclusion: Significant differences were noted between men and women in the appearance of concurrent pigmentary lesions and the distribution of lesions. Extra-facial acquired dermal melanocytosis was noted in men.

  8. ASSESSMENT OF ORGANIZATIONAL AND TECHNOLOGICAL RELIABILITY OF INDUSTRIAL CONSTRUCTION ENTERPRISES

    Directory of Open Access Journals (Sweden)

    Gazaryan Robert Kamoevich

    2012-10-01

    Full Text Available In this article, the procedure of identification of organizational and technological reliability is described. This methodology is applicable both to separate functional areas and to all industrial enterprises. Its objective is to assess the expediency of reorganization. The objective of this scientific research is the substantiation of reorganization of an industrial enterprise. Multivariable models, or convolutions, were used as research methods. According to the RF law, industrial enterprises are divided into four functional areas, each of which is assessed on the basis of multiple criteria. Assessment of organizational and technological reliability requires a multi-parameter model. Its axes correspond to the number of evaluation criteria. The set of criteria designated for the assessment of organizational and technological reliability is identified on the basis of the homogeneity of trend indicators designated for centripetal and centrifugal models. The axes of a multi-parameter model represent real and benchmark values. The unit serves as the benchmark value; it is the maximal value of this parameter. The formula based on average values shall be used to determine the total value of the above parameters. The authors have also generated a model of organizational and technological reliability of industrial enterprises. It is noteworthy that assessment of organizational and technological reliability of an industrial enterprise requires a concentric multi-layer model developed through the application of the convolution method.

  9. Technological and life cycle assessment of organics processing odour control technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bindra, Navin [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Dubey, Brajesh, E-mail: bkdubey@civil.iitkgp.ernet.in [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Environmental Engineering Division, Department of Civil Engineering, Indian Institute of Technology, Kharagpur, West Bengal 721302 (India); Dutta, Animesh [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada)

    2015-09-15

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories. - Highlights: • Assessment of odour control technologies for organics processing facilities. • Comparative life cycle assessment of three odour control technologies was conducted

  10. Technology Assessment Tool - An Application of Systems Engineering to USDOE Technology Proposals

    Energy Technology Data Exchange (ETDEWEB)

    Rynearson, Michael Ardel

    1999-06-01

    This paper discusses the system design for a Technology Assessment (TA) tool that can be used to quantitatively evaluate new and advanced technologies, products, or processes. Key features of the tool include organization of information in an indentured hierarchy; questions and categories derived from the decomposition of technology performance; segregation of life-cycle issues into six assessment categories; and scoring, relative impact, and sensitivity analysis capability. An advantage of the tool's use is its ability to provide decision analysis data, based on incomplete or complete data.

  11. Technology Assessment Tool - An Application of Systems Engineering to USDOE Technology Proposals

    Energy Technology Data Exchange (ETDEWEB)

    Rynearson, Michael Ardel

    1999-06-01

    This paper discusses the system design for a Technology Assessment (TA) tool that can be used to quantitatively evaluate new and advanced technologies, products, or processes. Key features of the tool include organization of information in an indentured hierarchy; questions and categories derived from the decomposition of technology performance; segregation of life-cycle issues into six assessment categories; and scoring, relative impact, and sensitivity analysis capability. An advantage of the tool's use is its ability to provide decision analysis data, based on incomplete or complete data.

  12. Technology Assessment Tool - An Application of Systems Engineering to USDOE Technology Proposals

    Energy Technology Data Exchange (ETDEWEB)

    M. A. Rynearson

    1999-06-01

    This paper discusses the system design of a Technology Assessment (TA) tool that can be used to quantitatively evaluate new and advanced technologies, products, or processes. Key features of the tool include organization of information in an indentured hierarchy; questions and categories derived from the decomposition of technology performance; segregation of life-cycle issues into six assessment categories; and scoring, relative impact, and sensitivity analysis capability. An advantage of the tool's use is its ability to provide decision analysis data, based on incomplete or complete data.

  13. "酒店+OTA"双渠道供应链的销售策略及协调机制研究%Research on Marketing Policy and Coordination Mechanism of"Hotel+OTA"Dual-Channel Supply Chain

    Institute of Scientific and Technical Information of China (English)

    浦徐进; 杜晓东

    2016-01-01

    在"酒店+OTA"双渠道供应链背景下,构建酒店和 OTA 网站之间的 Stacklberg 博弈模型,考察酒店的网站销售价格和网站促销努力的变化逻辑,并设计一个酒店分担 OTA网站促销努力成本的协调机制来改善供应链运作效率.研究发现:酒店房间数、通过前台订房的旅客数量均值等因素将影响酒店的销售策略;相比于集中决策下的情况,分散决策下 OTA网站的促销努力水平和供应链整体利润将降低;合理设计的促销成本分担机制可以实现酒店和 OTA网站双方利润水平的Pareto改进.研究结论将为促进"酒店+OTA"双渠道供应链的良性运作提供决策借鉴.%Considering the "Hotel+OTA"dual-channel supply chain,this paper builds a Stacklberg game model between the hotel and the OTA website,and analyzes the change logic of hotel's sales prices and the OTA website's promotion efforts.A new contract that the hotel shares a part of the OTA website's promotional effort costs is designed to coordinate the whole dual-channel supply chain.This paper also designs channel coordination with which hotel shares the OTA website's promotion effort cost to improve the operating efficiency of supply chain.Results show that:(1)Some factors,such as the number of hotel rooms and the average number of passengers who book at the front desk,will affect the hotel's marketing policy.(2)Compared with the centralized setting,the level of OTA website's promotion effort and the profit of the supply chain will decrease in the decentralized setting.(3 )The promotional cost-sharing mechanism can lead to a Pareto improvement of the profit level of both the hotel and the OTA website. These conclusions can provide decision-making reference for promoting the dual-channel supply chain for a hotel and a website to operate efficiently.

  14. HEALTH TECHNOLOGY ASSESSMENT ON CERVICAL CANCER SCREENING, 2000–2014

    OpenAIRE

    Lahue, Betsy J.; Baginska, Eva; Li, Sophia S.; Parisi, Monika

    2015-01-01

    Objectives: The aim of this study was to conduct a review of health technology assessments (HTAs) in cervical cancer screening to highlight the most common metrics HTA agencies use to evaluate and recommend cervical cancer screening technologies. Methods: The Center for Reviews and Dissemination (CRD), MedLine, and national HTA agency databases were searched using keywords (“cervical cancer screening” OR “cervical cancer” OR “cervical screening”) and “HTA” from January 2000 to October 2014. N...

  15. Nutrition and health technology assessment: when two worlds meet

    OpenAIRE

    Poley, Marten J.

    2015-01-01

    There is a growing recognition that nutrition may have a positive impact on public health and that it may reduce medical expenditures. Yet, such claims need to be substantiated by evidence. This evidence could be delivered by health technology assessment (HTA), which can be thought of as the evaluation of technologies for clinical effectiveness, cost-effectiveness, and ethical, legal, and social impacts. The application of HTA to the field of “nutrition interventions” is recent. So far, HTA a...

  16. Technological Implications for Assessment Ecosystems: Opportunities for Digital Technology to Advance Assessment

    Science.gov (United States)

    Behrens, John T.; DiCerbo, Kristen E.

    2014-01-01

    Background: It would be easy to think the technological shifts in the digital revolution are simple incremental progressions in societal advancement. However, the nature of digital technology is resulting in qualitative differences in nearly all parts of daily life. Purpose: This paper investigates how the new possibilities for understanding,…

  17. Health Monitoring System Technology Assessments: Cost Benefits Analysis

    Science.gov (United States)

    Kent, Renee M.; Murphy, Dennis A.

    2000-01-01

    The subject of sensor-based structural health monitoring is very diverse and encompasses a wide range of activities including initiatives and innovations involving the development of advanced sensor, signal processing, data analysis, and actuation and control technologies. In addition, it embraces the consideration of the availability of low-cost, high-quality contributing technologies, computational utilities, and hardware and software resources that enable the operational realization of robust health monitoring technologies. This report presents a detailed analysis of the cost benefit and other logistics and operational considerations associated with the implementation and utilization of sensor-based technologies for use in aerospace structure health monitoring. The scope of this volume is to assess the economic impact, from an end-user perspective, implementation health monitoring technologies on three structures. It specifically focuses on evaluating the impact on maintaining and supporting these structures with and without health monitoring capability.

  18. Phakomatosis Pigmentovascularis Associated With Sturge–Weber Syndrome, Ota Nevus, and Congenital Glaucoma

    Science.gov (United States)

    Yang, Yangfan; Guo, Xiujuan; Xu, Jiangang; Ye, Yiming; Liu, Xiaoan; Yu, Minbin

    2015-01-01

    Abstract Phakomatosis pigmentovascularis (PPV) is a rare congenital malformation syndrome that is characterized by a combination of capillary abnormalities and dermal melanocytosis. We describe 3 cases of PPV combined with bilateral Sturge–Weber syndrome (SWS), Ota nevus, and congenital glaucoma. Case 1 was a 2-year-old boy. Facial port-wine stains distributed along the 3 branches of his trigeminal nerves, which suggested the existence of SWS. Gray-blue patches were spread over the frontal and temporal areas of bilateral face, waist, buttocks, and thigh. Bilateral triangular alopecia was found on the temporal scalp. The diagnosis of Ota nevus was made by the bilateral scleral malanocystosis. Increased intraocular pressure, enlarged cornea, and pathologic optic disc cupping supported the diagnoses of infantile bilateral glaucoma. Case 2 was a 4-year-old boy. Port-wine stains were found on the face along the 3 branches of the trigeminal nerve and distributed along the trunk, arms, and legs. Mongolian spots spread over his frontal and temporal areas of the bilateral face, waist, buttocks, thigh, abdomen, and back. Infantile glaucoma was found in both eyes. Ota nevus were found in the both eyes. Optic coherent tomography (OCT) scans revealed increased thickness of choroid. Case 3 was a 5-year-old boy. Besides Ota nevus and infantile glaucoma in both eyes, color Doppler ultrasonography showed choroidal hemagioma. OCT scan showed increased choroidal thickness. The bilateral triangular alopecia on the child's temporal scalp was similar to that of Case 1. Cases 1 and 2 presented with port-wine stain patches that were consistent with the characteristic manifestation of PPV type IIb. However, the CMTC of Case 3 met the diagnostic criteria for PPV type Vb. Case 1 was treated with trabeculotomies in both eyes. For Cases 2 and 3, surgical interventions were not considered due to the high risks of antiglaucomatous operation complications. We prescribed them antiglaucoma

  19. Phakomatosis Pigmentovascularis Associated With Sturge-Weber Syndrome, Ota Nevus, and Congenital Glaucoma.

    Science.gov (United States)

    Yang, Yangfan; Guo, Xiujuan; Xu, Jiangang; Ye, Yiming; Liu, Xiaoan; Yu, Minbin

    2015-07-01

    Phakomatosis pigmentovascularis (PPV) is a rare congenital malformation syndrome that is characterized by a combination of capillary abnormalities and dermal melanocytosis.We describe 3 cases of PPV combined with bilateral Sturge-Weber syndrome (SWS), Ota nevus, and congenital glaucoma.Case 1 was a 2-year-old boy. Facial port-wine stains distributed along the 3 branches of his trigeminal nerves, which suggested the existence of SWS. Gray-blue patches were spread over the frontal and temporal areas of bilateral face, waist, buttocks, and thigh. Bilateral triangular alopecia was found on the temporal scalp. The diagnosis of Ota nevus was made by the bilateral scleral malanocystosis. Increased intraocular pressure, enlarged cornea, and pathologic optic disc cupping supported the diagnoses of infantile bilateral glaucoma. Case 2 was a 4-year-old boy. Port-wine stains were found on the face along the 3 branches of the trigeminal nerve and distributed along the trunk, arms, and legs. Mongolian spots spread over his frontal and temporal areas of the bilateral face, waist, buttocks, thigh, abdomen, and back. Infantile glaucoma was found in both eyes. Ota nevus were found in the both eyes. Optic coherent tomography (OCT) scans revealed increased thickness of choroid. Case 3 was a 5-year-old boy. Besides Ota nevus and infantile glaucoma in both eyes, color Doppler ultrasonography showed choroidal hemagioma. OCT scan showed increased choroidal thickness. The bilateral triangular alopecia on the child's temporal scalp was similar to that of Case 1. Cases 1 and 2 presented with port-wine stain patches that were consistent with the characteristic manifestation of PPV type IIb. However, the CMTC of Case 3 met the diagnostic criteria for PPV type Vb.Case 1 was treated with trabeculotomies in both eyes. For Cases 2 and 3, surgical interventions were not considered due to the high risks of antiglaucomatous operation complications. We prescribed them antiglaucoma indications

  20. Design of Biquad Universal Filter Using Operational Transconductance Amplifier in 180nm Technology

    Directory of Open Access Journals (Sweden)

    Rahul Kumar,

    2014-05-01

    Full Text Available This paper presents concept of universal filter using operational transconductance amplifier (OTA.The 0.18μm CMOS process is used for design and simulation. This OTA has basing current of 50μA with supply voltage ±1.25v. The design and simulation of this OTA is done using CADENCE virtuoso environment with UMC 0.18μm technology file. This paper presents a electronically tunable voltage mode universal biquadratic filter with Three input and single output using two single ended OTA and two capacitors. The proposed filter provides low-pass,High-pass,Band-pass and Band-stop by appropriately connecting the input terminals. The natural frequency and the quality factor can be set orthogonally by adjusting the circuit components.Also the natural frequency can be electronically tuned via the bias currents of OTAs.

  1. Guidelines for the assessment and optimization of turboexpansion technologies

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Philipp; Mastandrea, Martin [TECNA Estudios y Proyectos de Ingenieria S.A. (Argentina)

    2004-07-01

    The operating performance of a turbo expansion process depends on several factors among which we find: pressure, temperature and feed stream composition, expected recovery, pressure required for residual gas and products' specifications. The evolution of markets has set the development of several technologies; it is therefore complex, and rather impossible, to establish which of those technologies represents the most suitable choice for certain conditions by simply inspecting the above-mentioned factors. Guidelines for the assessment and optimization of available technologies are presented in this work. Also, relevant matters to be taken into account in the development of different units of a turbo expansion plant are mentioned. (author)

  2. Assessment of a satellite power system and six alternative technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wolsko, T.; Whitfield, R.; Samsa, M.; Habegger, L.S.; Levine, E.; Tanzman, E.

    1981-04-01

    The satellite power system is assessed in comparison to six alternative technologies. The alternatives are: central-station terrestrial photovoltaic systems, conventional coal-fired power plants, coal-gasification/combined-cycle power plants, light water reactor power plants, liquid-metal fast-breeder reactors, and fusion. The comparison is made regarding issues of cost and performance, health and safety, environmental effects, resources, socio-economic factors, and insitutional issues. The criteria for selecting the issues and the alternative technologies are given, and the methodology of the comparison is discussed. Brief descriptions of each of the technologies considered are included. (LEW)

  3. The contribution of health technology assessment, health needs assessment, and health impact assessment to the assessment and translation of technologies in the field of public health genomics.

    Science.gov (United States)

    Rosenkötter, N; Vondeling, H; Blancquaert, I; Mekel, O C L; Kristensen, F B; Brand, A

    2011-01-01

    The European Union has named genomics as one of the promising research fields for the development of new health technologies. Major concerns with regard to these fields are, on the one hand, the rather slow and limited translation of new knowledge and, on the other hand, missing insights into the impact on public health and health care practice of those technologies that are actually introduced. This paper aims to give an overview of the major assessment instruments in public health [health technology assessment (HTA), health needs assessment (HNA) and health impact assessment (HIA)] which could contribute to the systematic translation and assessment of genomic health applications by focussing at population level and on public health policy making. It is shown to what extent HTA, HNA and HIA contribute to translational research by using the continuum of translational research (T1-T4) in genomic medicine as an analytic framework. The selected assessment methodologies predominantly cover 2 to 4 phases within the T1-T4 system. HTA delivers the most complete set of methodologies when assessing health applications. HNA can be used to prioritize areas where genomic health applications are needed or to identify infrastructural needs. HIA delivers information on the impact of technologies in a wider scope and promotes informed decision making. HTA, HNA and HIA provide a partly overlapping and partly unique set of methodologies and infrastructure for the translation and assessment of genomic health applications. They are broad in scope and go beyond the continuum of T1-T4 translational research regarding policy translation.

  4. Review of early assessment models of innovative medical technologies

    DEFF Research Database (Denmark)

    Fasterholdt, Iben; Krahn, Murray D; Kidholm, Kristian

    2017-01-01

    INTRODUCTION: Hospitals increasingly make decisions regarding the early development of and investment in technologies, but a formal evaluation model for assisting hospitals early on in assessing the potential of innovative medical technologies is lacking. This article provides an overview of models...... for early assessment in different health organisations and discusses which models hold most promise for hospital decision makers. METHODS: A scoping review of published studies between 1996 and 2015 was performed using nine databases. The following information was collected: decision context, decision...... problem, and a description of the early assessment model. RESULTS: 2362 articles were identified and 12 studies fulfilled the inclusion criteria. An additional 12 studies were identified and included in the review by searching reference lists. The majority of the 24 early assessment studies were variants...

  5. Sustainability assessment of energy technologies. Towards an integrative framework

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, Armin; Roesch, Christine [Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen (DE). Inst. for Technology Assessment and Systems Analysis (ITAS)

    2011-12-15

    To be able to design and use energy technologies with regard to the needs of sustainable development, sustainability assessments are necessary prior to the respective decisions. However, as is known, they pose methodological problems: from the difficulties of anticipation of future developments via the determination of assessment criteria through to the necessity to define sustainable development accurately enough. In this contribution, we will introduce an integrative sustainability concept which has hardly been discussed in the energy context. We will analyse this concept with respect to deriving general principles for the sustainability assessment of energy technologies. As a case study, we consider in particular the field of the use of grassland for biomass production for energetic purposes. The integrative concept is shown to provide an overall framework to carry out comprehensible and, above all, comparative sustainability assessments. More or less as a by-product, it can be demonstrated that sustainability means also in the energy sector much more than just environmental compatibility. (orig.)

  6. Health technology assessment in Iran: challenges and views.

    Science.gov (United States)

    Olyaeemanesh, Alireza; Doaee, Shila; Mobinizadeh, Mohammadreza; Nedjati, Mina; Aboee, Parisa; Emami-Razavi, Seyed Hassan

    2014-01-01

    Various decisions have been made on technology application at all levels of the health system in different countries around the world. Health technology assessment is considered as one of the best scientific tools at the service of policy- makers. This study attempts to investigate the current challenges of Iran's health technology assessment and provide appropriate strategies to establish and institutionalize this program. This study was carried out in two independent phases. In the first, electronic databases such as Medline (via Pub Med) and Scientific Information Database (SID) were searched to provide a list of challenges of Iran's health technology assessment. The views and opinions of the experts and practitioners on HTA challenges were studied through a questionnaire in the second phase which was then analyzed by SPSS Software version 16. This has been an observational and analytical study with a thematic analysis. In the first phase, seven papers were retrieved; from which, twenty- two HTA challenges in Iran were extracted by the researchers; and they were used as the base for designing a structured questionnaire of the second phase. The views of the experts on the challenges of health technology assessment were categorized as follows: organizational culture, stewardship, stakeholders, health system management, infrastructures and external pressures which were mentioned in more than 60% of the cases and were also common in the views. The identification and prioritization of HTA challenges which were approved by those experts involved in the strategic planning of the Department of Health Technology Assessment will be a step forward in the promotion of an evidence- based policy- making and in the production of comprehensive scientific evidence.

  7. The NICE ADHD health technology assessment: A review and critique

    Directory of Open Access Journals (Sweden)

    Schlander Michael

    2008-01-01

    Full Text Available Abstract Background Health technology assessments (HTAs by the National Institute for Health and Clinical Excellence (NICE enjoy high levels of international attention. The present analysis addresses NICE's appraisal of methylphenidate, atomoxetine and dexamphetamine for attention-deficit/hyperactivity disorder (ADHD in children and adolescents, published in March 2006. Methods A qualitative study of NICE Technology Appraisal No. 98 was done focusing on the >600-page technology assessment report, which aimed at evaluating ADHD treatment strategies by a clinical effectiveness review and an economic analysis using meta-analytical techniques and a cost-effectiveness model. Results The technology assessment was unable to differentiate between the various drugs in terms of efficacy, and its economic model was ultimately driven by cost differences. While the assessment concluded that the economic model "clearly identified an optimal treatment strategy" with first-line dexamphetamine, the NICE appraisal committee subsequently found it impossible to distinguish between the different strategies on grounds of cost-effectiveness. Analyzing the assessment reveals gaps and inconsistencies concerning data selection (ultimately relying on a small number of short-term studies only, data synthesis (pooling of heterogeneous study designs and clinical endpoints, and economic model structure (identifying double-counting of nonresponders as a likely source of bias, alongside further methodological anomalies. Conclusion Many conclusions of the NICE technology assessment rest on shaky grounds. There remains a need for a new, state-of-the-art systematic review of ADHD treatment strategies including economic evaluation, which ideally should address outcomes beyond children's health-related quality of life, such as long-term sequelae of the disorder and caregiver burden.

  8. A prototype catalogue: DOE National Laboratory technologies for infrastructure modernization

    Energy Technology Data Exchange (ETDEWEB)

    Currie, J.W.; Wilfert, G.L.; March, F.

    1990-01-01

    The purpose of this report is to provide the Office of Technology Assessment (OTA) with information about selected technologies under development in the Department of Energy (DOE) through its National Laboratory System and its Program Office operations. The technologies selected are those that have the potential to improve the performance of the nation's public works infrastructure. The product is a relational database that we refer to as a prototype catalogue of technologies.'' The catalogue contains over 100 entries of DOE-supported technologies having potential application to infrastructure-related problems. The work involved conceptualizing an approach, developing a framework for organizing technology information, and collecting samples of readily available data to be put into a prototype catalogue. In developing the catalogue, our objectives were to demonstrate the concept and provide readily available information to OTA. As such, the catalogue represents a preliminary product. The existing database is not exhaustive and likely represents only a fraction of relevant technologies developed by DOE. In addition, the taxonomy we used to classify technologies is based on the judgment of project staff and has received minimal review by individuals who have been involved in the development and testing of the technologies. Finally, end users will likely identify framework changes and additions that will strengthen the catalogue approach. The framework for the catalogue includes four components: a description of the technology, along with potential uses and other pertinent information; identification of the source of the descriptive information; identification of a person or group knowledgeable about the technology; and a classification of the described technology in terms of its type, application, life-cycle use, function, and readiness.

  9. Teknologvurdering, Broer og Brugere (Technology Assessment: Bridges and Users)

    DEFF Research Database (Denmark)

    Munch, Birgitte

    A critique of the scientific approaches grounding Danish technology assessments for beingnon-reflexive upon the consequences of its biased treatment of who and how some countsas ‘users'. Implications and new approaches are outlined in a story of engineering designers conceptualization of ships...

  10. Assessment, Technology and Democratic Education in the Age of Data

    Science.gov (United States)

    Perrotta, Carlo

    2013-01-01

    This paper contends that powerful techniques to manipulate data, enabled by technological and economic developments, can be easily co-opted to serve the restrictive frameworks of hyper-controlling, managerial accountability that characterise current cultures of summative assessment in education. In response to these challenges, research is…

  11. Nutrition and health technology assessment: When two worlds meet

    NARCIS (Netherlands)

    M.J. Poley (Marten)

    2015-01-01

    textabstractThere is a growing recognition that nutrition may have a positive impact on public health and that it may reduce medical expenditures. Yet, such claims need to be substantiated by evidence. This evidence could be delivered by health technology assessment (HTA), which can be thought of as

  12. Integrating ethics in health technology assessment: many ways to Rome

    NARCIS (Netherlands)

    Hofmann, B.; Oortwijn, W.; Lysdahl, K. Bakke; Refolo, P.; Sacchini, D.; Wilt, G.J. van der; Gerhardus, A.

    2015-01-01

    OBJECTIVES: The aim of this study was to identify and discuss appropriate approaches to integrate ethical inquiry in health technology assessment (HTA). METHODS: The key question is how ethics can be integrated in HTA. This is addressed in two steps: by investigating what it means to integrate ethic

  13. Mapping of health technology assessment in selected countries

    NARCIS (Netherlands)

    Oortwijn, W.; Broos, P.; Vondeling, H.; Banta, D.; Todorova, L.

    2013-01-01

    Objectives: The aim of this study was to develop and apply an instrument to map the level of health technology assessment (HTA) development at country level in selected countries. We examined middle-income countries (Argentina, Brazil, India, Indonesia, Malaysia, Mexico, and Russia) and countries we

  14. Condition Assessment Technologies for Water Transmission and Distribution Systems

    Science.gov (United States)

    As part of the U.S. Environmental Protection Agency’s (EPA’s) Aging Water Infrastructure Research Program, this research was conducted to identify and characterize the state of the technology for structural condition assessment of drinking water transmission and distribution syst...

  15. Developmental toxicity testing for safety assessment: new approaches and technologies.

    Science.gov (United States)

    Knudsen, Thomas B; Kavlock, Robert J; Daston, George P; Stedman, Donald; Hixon, Mary; Kim, James H

    2011-10-01

    The ILSI Health and Environmental Sciences Institute's Developmental and Reproductive Toxicology Technical Committee held a 2-day workshop entitled "Developmental Toxicology-New Directions" in April 2009. The fourth session of this workshop focused on new approaches and technologies for the assessment of developmental toxicology. This session provided an overview of the application of genomics technologies for developmental safety assessment, the use of mouse embryonic stem cells to capture data on developmental toxicity pathways, dynamical cell imaging of zebrafish embryos, the use of computation models of development pathways and systems, and finally, high-throughput in vitro approaches being utilized by the EPA ToxCast program. Issues discussed include the challenges of anchoring in vitro predictions to relevant in vivo endpoints and the need to validate pathway-based predictions with targeted studies in whole animals. Currently, there are 10,000 to 30,000 chemicals in world-wide commerce in need of hazard data for assessing potential health risks. The traditional animal study designs for assessing developmental toxicity cannot accommodate the evaluation of this large number of chemicals, requiring that alternative technologies be utilized. Though a daunting task, technologies are being developed and utilized to make that goal reachable. © 2011 Wiley Periodicals, Inc.

  16. Early phase Technology Assessment of nanotechnology in oncology

    NARCIS (Netherlands)

    Retèl, Valesca P.; Hummel, Marjan J.M.; Harten, van Willem H.

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected

  17. Technology assessment of automation trends in the modular home industry

    Science.gov (United States)

    Phil Mitchell; Robert Russell Hurst

    2009-01-01

    This report provides an assessment of technology used in manufacturing modular homes in the United States, and that used in the German prefabricated wooden home industry. It is the first step toward identifying the research needs in automation and manufacturing methods that will facilitate mass customization in the home manufacturing industry. Within the United States...

  18. Reimbursement of pharmaceuticals: Reference pricing versus health technology assessment

    NARCIS (Netherlands)

    M. Drummond (Michael); B. Jönsson (Bengt); F.F.H. Rutten (Frans); T. Stargardt (Tom)

    2011-01-01

    textabstractReference pricing and health technology assessment are policies commonly applied in order to obtain more value for money from pharmaceuticals. This study focussed on decisions about the initial price and reimbursement status of innovative drugs and discussed the consequences for market a

  19. Framework for dementia Quality of Life assessment with Assistive Technology

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth; Prasad, Neeli R.; Prasad, Ramjee

    2010-01-01

    This paper proposes a theoretical framework for a Quality of Life (QOL) evaluation tool that is sensitive, flexible, computerized, and specific to assistive technology (AT) for dementia care. Using the appropriate evaluation tool serves to improve methodologies that are used for AT assessment...

  20. The Post-implementation Assessment of Advanced Technology Utilization

    Directory of Open Access Journals (Sweden)

    Hynek Josef

    2012-09-01

    Full Text Available Efficient utilization of advanced manufacturing technology is usually seen as one of the crucial factors in achieving competitiveness on global markets. On the other hand, there are many problems associated with the advanced technology utilization. These problems could be related to the individual phases of the relevant project life cycle - starting from the early stages of AMT projects preparation and evaluation, through various problems related to the project implementation, its integration within the company environment, up to the issues related to the efficient utilization of the already deployed system. This paper focuses on the final stage of this processwhen the post-implementation assessment should be carried out in order to determine whether all initial expectations and objectives were met and whether all the originally promised benefits were delivered. Typical problems of technology benefits evaluation together with various methods, concepts as well as metrics used in the process of the assessment will be discussed here in particular.

  1. Integration of tablet technologies in the e-laboratory of cytology: a health technology assessment.

    Science.gov (United States)

    Giansanti, Daniele; Pochini, Marco; Giovagnoli, Maria Rosaria

    2014-10-01

    Although tablet systems are becoming a powerful technology, particularly useful in every application of medical imaging, to date no one has investigated the acceptance and performance of this technology in digital cytology. The specific aims of the work were (1) to design a health technology assessment (HTA) tool to assess, in terms of performance and acceptance, the introduction of tablet technologies (wearable, portable, and non portable) in the e-laboratories of cytology and (2) to test the tool in a first significant application of digital cytology. An HTA tool was proposed operating on a domain of five dimensions of investigation comprising the basic information of the product of digital cytology, the perceived subjective quality of images, the assessment of the virtual navigation on the e-slide, the assessment of the information and communication technologies features, and the diagnostic power. Six e-slides regarding studies of cervicovaginal cytology digitalized by means of an Aperio ( www.aperio.com ) scanner and uploaded onto the www.digitalslide.it Web site were used for testing the methodology on three different network connections. Three experts of cytology successfully tested the methodology on seven tablets found suitable for the study in their own standard configuration. Specific indexes furnished by the tool indicated both a high degree of performance and subjective acceptance of the investigated technology. The HTA tool thus could be useful to investigate new tablet technologies in digital cytology and furnish stakeholders with useful information that may help them make decisions involving the healthcare system. From a global point of view the study demonstrates the feasibility of using the tablet technology in digital cytology.

  2. Early phase Technology Assessment of nanotechnology in oncology.

    Science.gov (United States)

    Retèl, Valesca P; Hummel, Marjan J M; van Harten, Willem H

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected to enter the oncology field it is relevant to consider the various aspects involved in especially early TA. This article provides two cases of early assessment of (predecessors of) nanotechnologies: Microarray Analysis and Photodynamic Therapy implementation, which methodology can be extrapolated to other nanotechnologies in oncology. Constructive Technology Assessment (CTA) is used for the introduction of technologies that are still in a dynamic phase of development or in an early stage of diffusion. The selection of studied aspects in CTA is based on: clinical aspects (safety, efficacy, and effectiveness), economic (cost-effectiveness), patient related (QoL, ethical/juridical and psychosocial), organizational aspects (diffusion and adoption) and scenario drafting. The features of the technology and the phase of implementation are decisive for choices and timing of the specific aspects to be studied. A framework was drafted to decide on the relevant aspects. In the first case, early implementation of Microarray Analysis; clinical effectiveness, logistics, patient centeredness and scenario drafting were given priority. Related to the diffusion-phase of Photodynamic Therapy however other aspects were evaluated, such as early cost-effectiveness analysis for possible reimbursement. Often CTA will result in a mixed method design. Especially scenario drafting is a powerful instrument to predict possible developments that can be anticipated upon in the assessment. CTA is appropriate for the study of early implementation of new technologies in oncology. In early TA small series often necessitate a mix of quantitative and qualitative methods. The features of nanotechnology

  3. Human factors assessments of innovative technologies: Robotics sector

    Energy Technology Data Exchange (ETDEWEB)

    Moran, J.B. [Operating Engineers National Hazmat Program, Beaver, WV (United States)

    1997-12-01

    The U.S. Department of Energy (DOE) has funded major environmental technology developments over the past several years. One area that received significant attention is robotics, which has resulted in the development of a wide range of unique robotic systems tailored to the many tasks unique to the DOE complex. These systems are often used in highly hazardous environments, which reduces or eliminates worker exposures. The DOE, concurrent with the technology development initiative, also established and funded a 5-yr cooperative agreement intended to interface with the technology development community-with specific attention to the occupational safety and health aspects associated with individual technologies through human factors and hazard assessments. This program is now in its third year.

  4. Readings in technology assessment. [in relation to social impact and the law

    Science.gov (United States)

    1975-01-01

    Papers are presented which reflect research in the following areas: development of the concept of technology assessment; institutionalization of technology assessment; the interface between law and technology assessment; and assessment case studies. Case studies include hazards of the medical use of X-rays, environmental noise effects in transportation planning, genetic technology, impact of underground coal mining, and aircraft/airport noise abatement.

  5. DECISION ANALYSIS AND TECHNOLOGY ASSESSMENTS FOR METAL AND MASONRY DECONTAMINATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian, Ph.D.

    1999-01-01

    The purpose of this investigation was to conduct a comparative analysis of innovative technologies for the non-aggressive removal of coatings from metal and masonry surfaces and the aggressive removal of one-quarter to one-inch thickness of surface from structural masonry. The technologies tested should be capable of being used in nuclear facilities. Innovative decontamination technologies are being evaluated under standard, non-nuclear conditions at the FIU-HCET technology assessment site in Miami, Florida. This study is being performed to support the OST, the Deactivation and Decommissioning (D&D) Focus Area, and the environmental restoration of DOE facilities throughout the DOE complex by providing objective evaluations of currently available decontamination technologies.

  6. Methods of synthesizing qualitative research studies for health technology assessment.

    Science.gov (United States)

    Ring, Nicola; Jepson, Ruth; Ritchie, Karen

    2011-10-01

    Synthesizing qualitative research is an important means of ensuring the needs, preferences, and experiences of patients are taken into account by service providers and policy makers, but the range of methods available can appear confusing. This study presents the methods for synthesizing qualitative research most used in health research to-date and, specifically those with a potential role in health technology assessment. To identify reviews conducted using the eight main methods for synthesizing qualitative studies, nine electronic databases were searched using key terms including meta-ethnography and synthesis. A summary table groups the identified reviews by their use of the eight methods, highlighting the methods used most generally and specifically in relation to health technology assessment topics. Although there is debate about how best to identify and quality appraise qualitative research for synthesis, 107 reviews were identified using one of the eight main methods. Four methods (meta-ethnography, meta-study, meta-summary, and thematic synthesis) have been most widely used and have a role within health technology assessment. Meta-ethnography is the leading method for synthesizing qualitative health research. Thematic synthesis is also useful for integrating qualitative and quantitative findings. Four other methods (critical interpretive synthesis, grounded theory synthesis, meta-interpretation, and cross-case analysis) have been under-used in health research and their potential in health technology assessments is currently under-developed. Synthesizing individual qualitative studies has becoming increasingly common in recent years. Although this is still an emerging research discipline such an approach is one means of promoting the patient-centeredness of health technology assessments.

  7. Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Turteltaub, K W; Hartman-Siantar, C; Easterly, C; Blakely, W

    2005-10-03

    A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of

  8. Investigation of Non-classical Under lap Design on Linearity of a Folded Cascode Operational Transconductance Amplifier (OTA)

    Science.gov (United States)

    Alam, M. S.; Kranti, A.; Armstrong, G. A.

    2011-08-01

    The significance of optimization of gate-source/drain extension region (also known as a non-classical underlap design) in double gate (DG) silicon-on-insulator (SOI) FETs to improve the linearity performance of a low power folded cascode operational transconductance amplifier (OTA) is described. Based on a new figure-of-merit (FoM) involving AV, linearity, unity gain bandwidth fT and dc power consumption PDC, this article presents guideline for optimum design for underlap spacer s and film thickness Tsi to maximize the performance of OTA. It has been shown that FoM exhibited by an underlap DG MOSFET OTA gives significantly higher value (≅9) compared to a conventional single gate bulk MOSFET OTA. This is due to a combination of both higher fT, and higher gain AV for the same linearity at low power consumption of 360 μW. With gate length scaling, FoM continues to improve, primarily due to higher value of fT. A scaled bulk MOSFET OTA exhibits similar but much smaller enhancement in trend for FoM.

  9. Multiple criteria decision analysis for health technology assessment.

    Science.gov (United States)

    Thokala, Praveen; Duenas, Alejandra

    2012-12-01

    Multicriteria decision analysis (MCDA) has been suggested by some researchers as a method to capture the benefits beyond quality adjusted life-years in a transparent and consistent manner. The objectives of this article were to analyze the possible application of MCDA approaches in health technology assessment and to describe their relative advantages and disadvantages. This article begins with an introduction to the most common types of MCDA models and a critical review of state-of-the-art methods for incorporating multiple criteria in health technology assessment. An overview of MCDA is provided and is compared against the current UK National Institute for Health and Clinical Excellence health technology appraisal process. A generic MCDA modeling approach is described, and the different MCDA modeling approaches are applied to a hypothetical case study. A comparison of the different MCDA approaches is provided, and the generic issues that need consideration before the application of MCDA in health technology assessment are examined. There are general practical issues that might arise from using an MCDA approach, and it is suggested that appropriate care be taken to ensure the success of MCDA techniques in the appraisal process. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  10. Treatment of AO/OTA 31-A3 intertrochanteric femoral fractures with a percutaneous compression plate

    Directory of Open Access Journals (Sweden)

    Fei Luo

    2014-01-01

    Full Text Available OBJECTIVE: AO/OTA 31-A3 intertrochanteric femoral fractures have completely different fracture line directions and biomechanical characteristics compared with other types of intertrochanteric fractures. The choice of the fixation method has been a focus of dispute among orthopedic trauma surgeons. The purpose of this study was to review the outcomes of these fractures treated with a percutaneous compression plate at our institute. METHOD: Seventeen patients with AO/OTA 31-A3 intertrochanteric femoral fractures were treated with a percutaneous compression plate at our institute from January 2010 to December 2011. The clinical data and imaging results were retrospectively analyzed. RESULTS: The medical complication of popliteal vein thrombosis occurred in one patient. Sixteen patients were followed up for 12 to 21 months. Two patients had malunion and mild pain. Fracture collapse occurred in two patients, with one having head penetration. These two patients had moderate pain. There were no occurrences of nonunion or reoperation. The mean Harris hip score obtained during the last follow-up was 84.1 (61-97. Patients with a poor quality of reduction were more likely to have pain results (p = 0.001. A trend existed toward the presence of a poor quality of reduction (p = 0.05 in patients with a collapse of fracture. Patients with poor preoperative mobility were more likely to have a lower Harris hip score (p = 0.000. CONCLUSION: The percutaneous compression plate is an alternative device for the treatment of AO/OTA 31-A3 intertrochanteric femoral fractures. Good fracture reduction and an ideal placement position of the neck screw are important in the success of the device.

  11. Technological and life cycle assessment of organics processing odour control technologies.

    Science.gov (United States)

    Bindra, Navin; Dubey, Brajesh; Dutta, Animesh

    2015-09-15

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories.

  12. The study of the life cycle of technology assessment model

    Institute of Scientific and Technical Information of China (English)

    SHEN Yu-Zhi; HUANG Xun-jiang

    2001-01-01

    The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo-tech. There are so many uncertainties because it is conditioned by a lot of factors, we can not make a rational forecasting by traditional assessment method. So this paper gives a conprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment. We can take it as one foundational index for the decision making of the investment.

  13. Knowledge in health technology assessment: who, what, how?

    Science.gov (United States)

    Tjørnhøj-Thomsen, Tine; Hansen, Helle Ploug

    2011-10-01

    Health systems are placing more and more emphasis on designing and delivering services that are focused on the patient, and there is a growing interest in patient aspects of health policy research and health technology assessment (HTA). Only a few HTA agencies use and invest in scientific methods to generate knowledge and evidence about the patient aspects of a given technology. This raises questions about how knowledge is produced in HTA reports and what kind of knowledge is considered relevant. This article uses a Danish HTA on patient education from 2009 as empirical material for a critical examination and discussion of knowledge and knowledge production about the patient aspects of HTA.

  14. Prioritizing Information Technology Investments: Assessing the Correlations among Technological Readiness, Information Technology Flexibility, and Information Technology Effectiveness

    Science.gov (United States)

    Walter, John T.

    2010-01-01

    Management's dilemma, when allocating financial resources towards the improvement of technological readiness and IT flexibility within their organizations, is to control financial risk and maximize IT effectiveness. Technological readiness is people's propensity to embrace and use technology. Its drivers are optimism, innovativeness, discomfort,…

  15. On Dimensions of OTA Setups for Massive MIMO Base Stations Radiated Testing

    DEFF Research Database (Denmark)

    Kyösti, Pekka; Fan, Wei; Pedersen, Gert F.;

    2016-01-01

    dimensions of the over-the-air (OTA) setups for the performance evaluation of massive multiple-input multiple-output (MIMO) BSs in anechoic chambers with multiple probes. Setup dimension is the major cost factor in the test systems and is thus the key issue to be investigated. The purpose is to determine...... (DoA) estimation algorithm as well as multi-user MIMO sum-rate capacity are investigated to determine the range of the test setup. It was found that the link budget doesn’t support for the measurement distances claimed by the Fraunhofer distance. Most of the utilized metrics, especially the sum rate...

  16. A reconfigurable OTA-C baseband filter with wide digital tuning for GNSS receivers

    Energy Technology Data Exchange (ETDEWEB)

    Pan Wenguang; Gan Yebing [Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029 (China); Ma Chengyan; Ye Tianchun, E-mail: panwenguang@casic.ac.c [Hangzhou Zhongke Microelectronics Co. Ltd, Hangzhou 310053 (China)

    2010-09-15

    The design of a digitally-tunable sixth-order reconfigurable OTA-C filter in a 0.18-{mu}m RFCMOS process is proposed. The filter can be configured as a complex band pass filter or two real low pass filters. An improved digital automatic frequency tuning scheme based on the voltage controlled oscillator technique is adopted to compensate for process variations. An extended tuning range (above 8:1) is obtained by using widely continuously tunable transconductors based on digital techniques. In the complex band pass mode, the bandwidth can be tuned from 3 to 24 MHz and the center frequency from 3 to 16 MHz. (semiconductor integrated circuits)

  17. Single MIMO-OTA and single-grounded-capacitor-based first-order allpass filter design

    Science.gov (United States)

    Psychalinos, C.; Pal, K.; Khanday, F. A.

    2014-12-01

    A novel first-order voltage-mode allpass (AP) filter employing a single multiple-input-multiple-output operational-transconductance-amplifier (MIMO-OTA) and a single grounded capacitor is introduced in this article. Compared to the corresponding already published topologies, the offered benefits are as follows: it employs minimum number of active and passive components; the only capacitor is grounded, which is good for a monolithic integration of an IC; and the absence of any matching condition for its realisability. The performance of the proposed circuit has been evaluated through simulation results, utilising the analogue design environment of Cadence software.

  18. Hanford Tank Farm Vapors Abatement Technology and Vendor Proposals Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Burns, H. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Farrar, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Fink, S. D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-20

    Suspected chemical vapor releases from the Hanford nuclear waste tank system pose concerns for worker exposure. Washington River Protection Solutions (WRPS) contracted the Savannah River National Laboratory (SRNL) to explore abatement technologies and strategies to remediate the vapors emitted through the ventilation system. In response, SRNL conducted an evaluation of technologies to abate, or reduce, vapor emissions to below 10% of the recognized occupational exposure limits (OELs). The evaluation included a review of published literature and a broadly communicated Request for Information to commercial vendors through a Federal Business Opportunities (Fed Biz Opps) web posting. In addition, SRNL conducted a workshop and post-workshop conference calls with interested suppliers (vendors) to assess proposals of relevant technologies. This report reviews applicable technologies and summarizes the approaches proposed by the vendors who participated in the workshop and teleconference interviews. In addition, the report evaluates the estimated performance of the individual technologies for the various classes of chemical compounds present in the Hanford Chemicals of Potential Concern (COPCs) list. Similarly, the report provides a relative evaluation of the vendor proposed approaches against criteria of: technical feasibility (and maturity), design features, operational considerations, secondary waste generation, safety/regulatory, and cost / schedule. These rough order-of-magnitude (ROM) cost estimates are intended to provide a comparison basis between technologies and are not intended to be actual project estimates.

  19. Hanford Tank Farm Vapors Abatement Technology and Vendor Proposals Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Burns, H. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Farrar, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Fink, S. D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-20

    Suspected chemical vapor releases from the Hanford nuclear waste tank system pose concerns for worker exposure. Washington River Protection Solutions (WRPS) contracted the Savannah River National Laboratory (SRNL) to explore abatement technologies and strategies to remediate the vapors emitted through the ventilation system. In response, SRNL conducted an evaluation of technologies to abate, or reduce, vapor emissions to below 10% of the recognized occupational exposure limits (OELs). The evaluation included a review of published literature and a broadly communicated Request for Information to commercial vendors through a Federal Business Opportunities (Fed Biz Opps) web posting. In addition, SRNL conducted a workshop and post-workshop conference calls with interested suppliers (vendors) to assess proposals of relevant technologies. This report reviews applicable technologies and summarizes the approaches proposed by the vendors who participated in the workshop and teleconference interviews. In addition, the report evaluates the estimated performance of the individual technologies for the various classes of chemical compounds present in the Hanford Chemicals of Potential Concern (COPCs) list. Similarly, the report provides a relative evaluation of the vendor proposed approaches against criteria of: technical feasibility (and maturity), design features, operational considerations, secondary waste generation, safety/regulatory, and cost / schedule. These rough order magnitude (ROM) cost estimates are intended to provide a comparison basis between technologies and are not intended to be actual project estimates.

  20. Recent Life Assessment Technology for Existing Steam Turbines

    Science.gov (United States)

    Saito, Kiyoshi; Sakuma, Akira; Fukuda, Masataka

    A large and growing portion of electricity is produced by aging thermal power plants. Although excellent, high quality materials such as CrMoV steel and 12% Cr steel, etc. are used for the steam turbines, various forms of metallurgical degradation, due to creep and fatigue, etc. affect the parts and components during long-term operation at high temperature. Extending the life of steam turbines and ensuring high reliability requires life assessment technology, scheduled repairing, conversion, modification and upgrading of components in order to provide a stable power supply. As the high temperature parts and components of aged steam turbines are mainly metallurgically damaged by creep, fatigue and the interaction of both, life assessment combined with analytical and nondestructive methods is essential for realizing strategic plant life extension. We have developed a life assessment technology that takes material degradation into consideration, and have applied the procedure to more than 650 units and 2500 components since 1983. A rotor bore replication device was developed in 1989 for the purpose of nondestructive observation of creep voids and supporting the validity of life prediction results. This paper describes the technical features and applied experience of recent life assessment technology for existing high temperature steam turbines.

  1. Teacher Learning of Technology-Enhanced Formative Assessment

    CERN Document Server

    Beatty, Ian D; Leonard, William J; Gerace, William J; Cyr, Karen St; Lee, Hyunju; Harris, Robby

    2008-01-01

    Technology-Enhanced Formative Assessment (TEFA) is a pedagogy for teaching with classroom response technology. Teacher Learning of TEFA is a five-year research project studying teacher change, in the context of an intensive professional development program designed to help science and mathematics teachers learn TEFA. First, we provide an overview of the project's participating teachers, its intervention (consisting of the technology, the pedagogy, and the professional development program), and its research design. Then, we present narratives describing the unfolding change process experienced by four teachers. Afterward, we present some preliminary findings of the research, describe a "model for the co-evolution of teacher and pedagogy" that we are developing, and identify general implications for professional development.

  2. Proposal for a state health technology assessment program.

    Science.gov (United States)

    Colmenares, Phil

    2012-08-01

    Evidence suggests that a significant number of medical technologies are of little or no benefit to patients. Under current budgetary pressures, state health care programs cannot afford continued spending on unnecessary medical care without further cuts in enrollment. Limiting coverage of high-tech care only to indications supported by good clinical evidence would help save state health care dollars. However, there is currently no public process to formally evaluate new medical interventions in Wisconsin. In fact, new therapies often are introduced into clinical practice, and covered by state health insurance programs, even when there is weak or questionable evidence of clinical effectiveness. This article proposes the creation of a state Health Technology Assessment program in Wisconsin to systematically evaluate new tests or treatments, and to promote evidence-based coverage decisions. Such a program would help limit wasteful spending on unnecessary technologies, reinforce good clinical practice, and protect patients from the risks of interventions that have not been proven effective.

  3. Technical and economic assessment of energy conversion technologies for MSW

    Energy Technology Data Exchange (ETDEWEB)

    Livingston, W.R.

    2002-07-01

    Thermal processes for municipal solid wastes (MSW) based on pyrolysis and/or gasification that have relevance to the emerging UK market are described in this report, and the results of the technical and economical assessment of these processes are presented. The Mitsui R21 Technology, the Thermoselect Process, the Nippon Steel Waste Melting Process, the Pyropleq Process, and the Compact Power Process are selected for detailed comparison on the basis of the overall technical concept, the energy balance and the requirements for consumables, environmental performance, and the technical and commercial status of the technology. Details are also given of a comparison of the novel thermal technologies with conventional mass burn incineration for MSW.

  4. ECASTAR: Energy Conservation; an Assessment of Systems, Technologies and Requirements

    Science.gov (United States)

    1975-01-01

    A methodology for a systems approach display and assessment of the potential for energy conservation actions and the impacts of those actions was presented. The U.S. economy is divided into four sectors: energy industry, industry, residential/commercial and transportation. Each sector is assessed with respect to energy conservation actions and impacts. The four sectors are combined and three strategies for energy conservation actions for the combined sectors are assessed. The three strategies (national energy conservation, electrification and diversification) represent energy conservation actions for the near term (now to 1985), the mid term (1985 to 2000) and the far term (2000 and beyond). The assessment procedure includes input/output analysis to bridge the flows between the sectors, and net economics and net energetics as performance criteria for the conservation actions. Targets of opportunity for large net energy net energy savings and the application of technology to achieve these savings are discussed.

  5. Implementation of Relevant Methods in Assessing Traffic-Technological Projects

    Directory of Open Access Journals (Sweden)

    Danijela Barić

    2007-09-01

    Full Text Available The assessment of investment traffic-technological projectsmeans a set of activities whose basic aim is to determine the justificationand feasibility of the projects. The decision-makingprocess, including the decision-making on investments is an extremelycomplex process, and the decision-maker has to have avision of the future and make decisions accordingly in a modemand flexible manner. Therefore, the decisions need to be theresult of a planning and research process based on relevant scientificmethods. The work includes the selected, analysed andpresented methods of cost-benefit analysis, methods of multi-criteria decision-making and SWOT (Strengths, Weaknesses,Opportunities, and Threats analysis methods. Regarding thebasic characteristics, the mentioned methods have been compared,the order of their implementation has been determined,and then they have been implemented in assessing the traffic-technological projects of reconstmction with the aim of selectingthe optimal variant solution.

  6. Environmental assessment of solid waste systems and technologies: EASEWASTE

    DEFF Research Database (Denmark)

    Kirkeby, Janus Torsten; Birgisdottir, Harpa; Hansen, Trine Lund

    2006-01-01

    to optimize current waste management systems with respect to environmental achievements and by authorities to Set Guidelines and regulations and to evaluate different strategies for handling of waste. The waste hierarchy has for decades been governing waste management but the ranking of handling approaches......A new model has been developed for evaluating the overall resource consumption and environmental impacts of municipal solid waste management systems by the use of life cycle assessment. The model is named EASEWASTE (Environmental Assessment of Solid Waste Systems and Technologies) and is able...... to compare different waste management strategies, waste treatment methods and waste process technologies. The potential environmental impacts can be traced back to the most important processes and waste fractions that contribute to the relevant impacts. A model like EASEWASTE can be used by waste planners...

  7. Hospital Based Health Technology Assessment: an example from Siena

    Directory of Open Access Journals (Sweden)

    Pietro Manzi

    2015-03-01

    Full Text Available The Health Technology Assessment (HTA has emerged in recent years as a useful tool in healthcare decision-making. It is a multidisciplinary process that summarizes information about the medical, social, economic and ethical issues related to the use of a health technology and provides evidence-based information on how to allocate resources. The experience of Siena University Hospital is an example of multidisciplinary hospital-based HTA. In the present paper we summarize the organization of HTA commission and the assessment methodology of the purchase, rental or sale of medical equipment and medical devices. Furthermore we illustrate the data concerning the commission activities in 2013.http://dx.doi.org/10.7175/fe.v16i1.943

  8. National Wind Technology Center sitewide, Golden, CO: Environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The National Renewable Energy Laboratory (NREL), the nation`s primary solar and renewable energy research laboratory, proposes to expand its wind technology research and development program activities at its National Wind Technology Center (NWTC) near Golden, Colorado. NWTC is an existing wind energy research facility operated by NREL for the US Department of Energy (DOE). Proposed activities include the construction and reuse of buildings and facilities, installation of up to 20 wind turbine test sites, improvements in infrastructure, and subsequent research activities, technology testing, and site operations. In addition to wind turbine test activities, NWTC may be used to support other NREL program activities and small-scale demonstration projects. This document assesses potential consequences to resources within the physical, biological, and human environment, including potential impacts to: air quality, geology and soils, water resources, biological resources, cultural and historic resources, socioeconomic resources, land use, visual resources, noise environment, hazardous materials and waste management, and health and safety conditions. Comment letters were received from several agencies in response to the scoping and predecisional draft reviews. The comments have been incorporated as appropriate into the document with full text of the letters contained in the Appendices. Additionally, information from the Rocky Flats Environmental Technology Site on going sitewide assessment of potential environmental impacts has been reviewed and discussed by representatives of both parties and incorporated into the document as appropriate.

  9. An assessment of acid rock drainage continuous monitoring technology

    Science.gov (United States)

    Fytas, K.; Hadjigeorgiou, J.

    1995-02-01

    In order to assess the magnitude and impact at affected mine sites of acid rock drainage (ARD), fixed-frequency sampling is often employed. This often involves manual sampling, at regular time intervals, of water and solids. It is felt that such sampling does not adequately describe the system evolution. Continuous monitoring offers a viable alternative in that it can better follow the seasonal fluctuations and high-frequency variations that characterize ARD. This paper evaluates existing continuous monitoring technology.

  10. Preliminary technology utilization assessment of the robotic fruit harvester

    Science.gov (United States)

    Wilhelm, J.

    1982-01-01

    The results of an analysis whose purpose was to examine the history and progress of mechanical fruit harvesting, to determine the significance of a robotic fruit tree harvester and to assess the available market for such a product are summarized. Background information that can be used in determining the benefit of a proof of principle demonstration is provided. Such a demonstration could be a major step toward the transfer of this NASA technology.

  11. Zero-emission vehicle technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Woods, T.

    1995-08-01

    This is the final report in the Zero-Emission Vehicle (ZEV) Technology Assessment, performed for NYSERDA by Booz-Allen & Hamilton Inc. Booz-Allen wrote the final report, and performed the following tasks as part of the assessment: assembled a database of key ZEV organizations, their products or services, and plans; described the current state of ZEV technologies; identified barriers to widespread ZEV deployment and projected future ZEV technical capabilities; and estimated the cost of ZEVs from 1998 to 2004. Data for the ZEV Technology Assessment were obtained from several sources, including the following: existing ZEV industry publications and Booz-Allen files; major automotive original equipment manufacturers; independent electric vehicle manufacturers; battery developers and manufacturers; infrastructure and component developers and manufacturers; the U.S. Department of Energy, the California Air Resources Board, and other concerned government agencies; trade associations such as the Electric Power Research Institute and the Electric Transportation Coalition; and public and private consortia. These sources were contacted by phone, mail, or in person. Some site visits of manufacturers also were conducted. Where possible, raw data were analyzed by Booz-Allen staff and/or verified by independent sources. Performance data from standardized test cycles were used as much as possible.

  12. Technology and economic assessment of lactic acid production and uses

    Energy Technology Data Exchange (ETDEWEB)

    Datta, R.; Tsai, S.P.

    1996-03-01

    Lactic acid has been an intermediate-volume specialty chemical (world production {approximately}50,000 tons/yr) used in a wide range of food-processing and industrial applications. Potentially, it can become a very large-volume, commodity-chemical intermediate produced from carbohydrates for feedstocks of biodegradable polymers, oxygenated chemicals, environmentally friendly ``green`` solvents, and other intermediates. In the past, efficient and economical technologies for the recovery and purification of lactic acid from fermentation broths and its conversion to the chemical or polymer intermediates had been the key technology impediments and main process cost centers. Development and deployment of novel separations technologies, such as electrodialysis with bipolar membranes, extractive and catalytic distillations, and chemical conversion, can enable low-cost production with continuous processes in large-scale operations. The emerging technologies can use environmentally sound lactic acid processes to produce environmentally useful products, with attractive process economics. These technology advances and recent product and process commercialization strategies are reviewed and assessed.

  13. Assessing effects of technology usage on mathematics learning

    Science.gov (United States)

    Lynch, Julianne

    2006-12-01

    Computer-based technologies are now commonplace in classrooms, and the integration of these media into the teaching and learning of mathematics is supported by government policy in most developed countries. However, many questions about the impact of computer-based technologies on classroom mathematics learning remain unanswered, and debates about when and how they ought to be used continue. An increasing number of studies seek to identify the effects of technology usage on classroom learning, and at a time when governments are calling for `evidence-based' policy development, many studies applying quasi-scientific methodologies to this field of practice are emerging. By analysing a series of conceptual frameworks for assessing the use of computer-based technologies to support school learning, this article emphasises the value of research into the relationship between technical and conceptual aspects of technology use in mathematics education and beyond, and challenges the usefulness of large-scale, quasi-scientific studies that focus on educational inputs and outputs.

  14. An assessment of desiccant cooling and dehumidification technology

    Energy Technology Data Exchange (ETDEWEB)

    Mei, V.C.; Chen, F.C. (Oak Ridge National Lab., TN (United States)); Lavan, Z. (Illinois Inst. of Tech., Chicago, IL (United States)); Collier, R.K. Jr. (Collier Engineering Services, Merritt Island, FL (United States)); Meckler, G. (Gershon Meckler Associates, P.C., Herndon, VA (United States))

    1992-07-01

    Desiccant systems are heat-actuated cooling and dehumidification technology. With the recent advances in this technology, desiccant systems can now achieve a primary energy coefficient of performance (COP) between 1.3 and 1.5, with potential to go to 1.7 and higher. It is becoming one of the most promising alternatives to conventional cooling systems. Two important and well-known advantages of desiccant cooling systems are that they are CFC free and they can reduce the electricity peak load. Another important but lesser-known advantage of desiccant technology is its potential for energy conservation. The energy impact study in this report indicated that a possible 13% energy saving in residential cooling and 8% in commercial cooling is possible. Great energy saving potential also exists in the industrial sector if industrial waste heat can be used for desiccant regeneration. The latest study on desiccant-integrated building heating, ventilating, and air conditioning (HVAC) systems indicated that the initial cost for the conventional cooling equipment was greatly reduced by using desiccant technology because of downsized compressors, fans, and ductworks. This cost reduction was more than enough to offset the cost of desiccant equipment. Besides, the system operation cost was also reduced. All these indicate that desiccant systems are also cost effective. This study provides an updated state-of-the-art assessment forsiccant technology in the field of desiccant materials, systems, computer models, and theoretical analyses. From this information the technology options were derived and the future research and development needs were identified. Because desiccant technology has already been applied in the commercial building sector with very encouraging results, it is expected that future market breakthroughs will probably start in this sector. A market analysis for the commercial building application is therefore included.

  15. Treatment of 522 patients with Nevus of Ota with Q-switc hed Alexandrite laser

    Institute of Scientific and Technical Information of China (English)

    卢忠; 方丽华; 焦圣; 黄雯; 陈军庞; 王侠生

    2003-01-01

    Objective To evaluate the clinical response of Nevus of Ota to Q-switched Alexandrite laser, and analyze factors that influence the treatment outcome.Methods A total of 522 patients treated with Q-switched Alexandrite laser were included in the study. Single and multiple variate analyses of various factors were per formed. Results Satisfactory result was observed in all patients, none of whom developed scarring. Clinical response was improved with additional treatment sessions. The clin ical response of the 20-27-week treatment interval group was significantly better t han that of the 12-19-week interval group, but showed no significant difference as compared with both the 28-35 and ≥36-week interval group. Zygomatic, bucc al and frontal areas showed better response than ocular and temporal areas. Tre atment session, interval, and fluence were significant factors identified by mul tivariate analysis. Conclusions Q-switched Alexandrite laser is an ideal method for treating Nevus of Ota without injury. The number of treatment sessions is more important than interval or fluence.

  16. Ota City : characterizing output variability from 553 homes with residential PV systems on a distribution feeder.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S.; Miyamoto, Yusuke (Kandenko, Ibaraki, Japan); Nakashima, Eichi (Kandenko, Ibaraki, Japan); Lave, Matthew

    2011-11-01

    This report describes in-depth analysis of photovoltaic (PV) output variability in a high-penetration residential PV installation in the Pal Town neighborhood of Ota City, Japan. Pal Town is a unique test bed of high-penetration PV deployment. A total of 553 homes (approximately 80% of the neighborhood) have grid-connected PV totaling over 2 MW, and all are on a common distribution line. Power output at each house and irradiance at several locations were measured once per second in 2006 and 2007. Analysis of the Ota City data allowed for detailed characterization of distributed PV output variability and a better understanding of how variability scales spatially and temporally. For a highly variable test day, extreme power ramp rates (defined as the 99th percentile) were found to initially decrease with an increase in the number of houses at all timescales, but the reduction became negligible after a certain number of houses. Wavelet analysis resolved the variability reduction due to geographic diversity at various timescales, and the effect of geographic smoothing was found to be much more significant at shorter timescales.

  17. QUALITY ASSESSMENT OF ETHICS ANALYSES FOR HEALTH TECHNOLOGY ASSSESSMENT.

    Science.gov (United States)

    Scott, Anna Mae; Bond, Kenneth; Gutiérrez-Ibarluzea, Iñaki; Hofmann, Björn; Sandman, Lars

    2016-01-01

    Although consideration of ethical issues is recognized as a crucial part of health technology assessment, ethics analysis for HTA is generally perceived as methodologically underdeveloped in comparison to other HTA domains. The aim of our study is (i) to verify existing tools for quality assessment of ethics analyses for HTA, (ii) to consider some arguments for and against the need for quality assessment tools for ethics analyses for HTA, and (iii) to propose a preliminary set of criteria that could be used for assessing the quality of ethics analyses for HTA. We systematically reviewed the literature, reviewed HTA organizations' Web sites, and solicited views from thirty-two experts in the field of ethics for HTA. The database and HTA agency Web site searches yielded 420 references (413 from databases, seven from HTA Web sites). No formal instruments for assessing the quality of ethics analyses for HTA purposes were identified. Thirty-two experts in the field of ethics for HTA from ten countries, who were brought together at two workshops held in Edmonton (Canada) and Cologne (Germany) confirmed the findings from the literature. Generating a quality assessment tool for ethics analyses in HTA would confer considerable benefits, including methodological alignment with other areas of HTA, increase in transparency and transferability of ethics analyses, and provision of common language between the various participants in the HTA process. We propose key characteristics of quality assessment tools for this purpose, which can be applied to ethics analyses for HTA purposes.

  18. A consumer involvement model for health technology assessment in Canada.

    Science.gov (United States)

    Pivik, Jayne; Rode, Elisabeth; Ward, Christopher

    2004-08-01

    Similar to other health policy initiatives, there is a growing movement to involve consumers in decisions affecting their treatment options. Access to treatments can be impacted by decisions made during a health technology assessment (HTA), i.e., the rigorous assessment of medical interventions such as drugs, vaccines, devices, materials, medical and surgical procedures and systems. The purpose of this paper was to empirically assess the interest and potential mechanisms for consumer involvement in HTA by identifying what health consumer organizations consider meaningful involvement, examining current practices internationally and developing a model for involvement based on identified priorities and needs. Canadian health consumer groups representing the largest disease or illness conditions reported a desire for involvement in HTA and provided feedback on mechanisms for facilitating their involvement.

  19. The politics of health technology assessment in Poland.

    Science.gov (United States)

    Ozieranski, Piotr; McKee, Martin; King, Lawrence

    2012-12-01

    First, to identify risks associated with the scientific evaluation of drugs considered for state reimbursement in Poland through exploring strategies of influence employed by multinational drug companies in relation to the Agency for Health Technology Assessment (AHTAPol). Second, to ascertain whether the outcomes of drug evaluation meet the interests of the public payer in reimbursing cost-effective drugs supported by robust pharmacoeconomic evidence. We conducted 109 in-depth semi-structured interviews with a purposive sample of stakeholders involved in the reimbursement process in Poland. We analysed four available documentary sources, including recommendations issued by the AHTAPol. AHTAPol recommendations were an instrumental part of the blame avoidance strategy by political elites. Drug producers utilised direct and indirect strategies of influence. The direct strategies involved building relationships with a circle of health technology assessment analysts and medical experts working for the Agency. The indirect strategies employed leaders of opinion in the medical milieu, patient organisations, and political elites to endorse policy positions favourable to drug companies. The AHTAPol positively recommended an increasing proportion of the drugs it assessed, many of them reported as not cost-effective or supported by dubious pharmacoeconomic evidence. The strategies of influence entail a number of risks that may undermine the scientific evaluation of drugs. Some outcomes of drug evaluation may favour the interests of multinational drug companies over those of the public payer. We suggest that the risks involved in drug evaluation might be mitigated through (1) professionalization of health technology assessment; (2) restriction of job seeking and post public-payer employment; (3) disclosure and management of experts' conflicts of interest; (4) institutionalisation of patient and public involvement; and (5) increased institutional separation of the AHTAPol from

  20. Connected Classroom Technology Facilitates Multiple Components of Formative Assessment Practice

    Science.gov (United States)

    Shirley, Melissa L.; Irving, Karen E.

    2015-02-01

    Formative assessment has been demonstrated to result in increased student achievement across a variety of educational contexts. When using formative assessment strategies, teachers engage students in instructional tasks that allow the teacher to uncover levels of student understanding so that the teacher may change instruction accordingly. Tools that support the implementation of formative assessment strategies are therefore likely to enhance student achievement. Connected classroom technologies (CCTs) include a family of devices that show promise in facilitating formative assessment. By promoting the use of interactive student tasks and providing both teachers and students with rapid and accurate data on student learning, CCT can provide teachers with necessary evidence for making instructional decisions about subsequent lessons. In this study, the experiences of four middle and high school science teachers in their first year of implementing the TI-Navigator™ system, a specific type of CCT, are used to characterize the ways in which CCT supports the goals of effective formative assessment. We present excerpts of participant interviews to demonstrate the alignment of CCT with several main phases of the formative assessment process. CCT was found to support implementation of a variety of instructional tasks that generate evidence of student learning for the teacher. The rapid aggregation and display of student learning evidence provided teachers with robust data on which to base subsequent instructional decisions.

  1. Expanding Health Technology Assessments to Include Effects on the Environment.

    Science.gov (United States)

    Marsh, Kevin; Ganz, Michael L; Hsu, John; Strandberg-Larsen, Martin; Gonzalez, Raquel Palomino; Lund, Niels

    2016-01-01

    There is growing awareness of the impact of human activity on the climate and the need to stem this impact. Public health care decision makers from Sweden and the United Kingdom have started examining environmental impacts when assessing new technologies. This article considers the case for incorporating environmental impacts into the health technology assessment (HTA) process and discusses the associated challenges. Two arguments favor incorporating environmental impacts into HTA: 1) environmental changes could directly affect people's health and 2) policy decision makers have broad mandates and objectives extending beyond health care. Two types of challenges hinder this process. First, the nascent evidence base is insufficient to support the accurate comparison of technologies' environmental impacts. Second, cost-utility analysis, which is favored by many HTA agencies, could capture some of the value of environmental impacts, especially those generating health impacts, but might not be suitable for addressing broader concerns. Both cost-benefit and multicriteria decision analyses are potential methods for evaluating health and environmental outcomes, but are less familiar to health care decision makers. Health care is an important and sizable sector of the economy that could warrant closer policy attention to its impact on the environment. Considerable work is needed to track decision makers' demands, augment the environmental evidence base, and develop robust methods for capturing and incorporating environmental data as part of HTA.

  2. Life cycle assessment of products and technologies. LCA Symposium

    Energy Technology Data Exchange (ETDEWEB)

    Koukkari, H.; Nors, M. (eds.)

    2009-12-15

    VTT Technical Research Centre of Finland organised a Symposium 'Life Cycle Assessment of Products and Technologies' on the 6th of October, 2009. The Symposium gave a good overview of methods, tools and applications of Life Cycle Assessment developed and utilised in several technology fields of VTT. The 12 Symposium papers deal with recent LCA studies on products and technologies. The scope ranges from beverage cups to urban planning, from inventory databases to rating systems. Topical issues relating to climate change concern biorefineries and the overall impacts of the utilisation of biomass. The calculation of carbon footprints is also introduced through paper products and magazines. One example of LCA tools developed at VTT addresses cement manufacturing. VTT's transport emission database, LIPASTO, was introduced in detail. The use of LCA methods and life cycle thinking is described in various contexts: product development in relation to precision instruments; selection of materials and work processes in relation to sediment remediation project; and procedures of sustainability rating through VTT's office building Digitalo. The Climate Bonus project presented a demonstrated ICT support that informs about the greenhouse gas emissions and carbon footprints of households. (orig.)

  3. Gender in health technology assessment: pilot study on agency approaches.

    Science.gov (United States)

    Panteli, Dimitra; Zentner, Annette; Storz-Pfennig, Philipp; Busse, Reinhard

    2011-07-01

    Gender as a social construct is a recognized health determinant. Because best practice in reporting health technology assessment (HTA) clearly specifies the need to appraise a technology's social impact within the target population, the extent to which gender issues are taken into account in HTA production is of interest, not only in light of equitable practices but also for reasons of effectiveness. The aim of this study is to provide a first assessment of the degree of gender sensitivity shown by HTA agencies around the world today. The Web sites of sixty HTA agencies were analyzed. The consideration of gender aspects was specifically looked for in each agency's general mission statement, its priority setting process, and its methodological approach. Additionally, specific gender-oriented initiatives not belonging to any of the aforementioned categories were identified. Of the sixty agencies, less than half mention a commitment to addressing the social implication of health technologies. Only fifteen institutions make information on their priority setting principles available on their Web sites and gender was an issue in two of those cases. Data on methodology were obtainable online from 18 agencies, two of which mentioned gender issues explicitly. Finally, gender-oriented initiatives were identified by thirteen agencies. A gender-sensitive approach is apparently rarely adopted in current HTA production. Exceptional practices and relevant tools do exist and could serve as examples to be promoted by international collaborative networks.

  4. Development and Implementation of Health Technology Assessment: A Policy Study

    Directory of Open Access Journals (Sweden)

    P Abooee

    2013-01-01

    Full Text Available Background: To provide an overview of the development of health technology assessment (HTA in Iran since 2007, and to facilitate further development of HTA and its integration into policy making.Methods: Data of this study were collected through key documents (e.g. literature, laws, and other official documentation and analyzed by experts of opinion in form of qualitative methods.Results: Health technology assessment entered to the political agenda in Iran only in 2007 with a strong impetus of an evidence-based medicine movement with the bellow objectives: Institutionalization of evidence-based decision making in Ministry of Health, Creating an localization for structural HTA in Health system of Iran, Setting up training courses in order to educate capable manpower to full up the capacity of the universities, Establishment of a new field in HTA subject in medical universities for MSc and PhD degree, International communication about HTA through national website and possible participation in international Congress.Conclusion: HTA has been established in the healthcare system of Iran but what is needed is a clear political will to push forward the objectives of HTA in Iran. Similar to other countries, advance the regulation on the adoption of new health technologies to improve not only technical or allocate efficiency, but also health equity.

  5. Environmental assessment of digestate treatment technologies using LCA methodology.

    Science.gov (United States)

    Vázquez-Rowe, Ian; Golkowska, Katarzyna; Lebuf, Viooltje; Vaneeckhaute, Céline; Michels, Evi; Meers, Erik; Benetto, Enrico; Koster, Daniel

    2015-09-01

    The production of biogas from energy crops, organic waste and manure has augmented considerably the amounts of digestate available in Flanders. This has pushed authorities to steadily introduce legislative changes to promote its use as a fertilising agent. There is limited arable land in Flanders, which entails that digestate has to compete with animal manure to be spread. This forces many anaerobic digestion plants to further treat digestate in such a way that it can either be exported or the nitrogen be removed. Nevertheless, the environmental impact of these treatment options is still widely unknown, as well as the influence of these impacts on the sustainability of Flemish anaerobic digestion plants in comparison to other regions where spreading of raw digestate is allowed. Despite important economic aspects that must be considered, the use of Life Cycle Assessment (LCA) is suggested in this study to identify the environmental impacts of spreading digestate directly as compared to four different treatment technologies. Results suggest relevant environmental gains when the digestate mix is treated using the examined conversion technologies prior to spreading, although important trade-offs between impact categories were observed and discussed. The promising results of digestate conversion technologies suggest that further LCA analyses should be performed to delve into, for instance, the appropriateness to shift to nutrient recovery technologies rather than digestate conversion treatments.

  6. Stochastic Technology Choice Model for Consequential Life Cycle Assessment.

    Science.gov (United States)

    Kätelhön, Arne; Bardow, André; Suh, Sangwon

    2016-12-06

    Discussions on Consequential Life Cycle Assessment (CLCA) have relied largely on partial or general equilibrium models. Such models are useful for integrating market effects into CLCA, but also have well-recognized limitations such as the poor granularity of the sectoral definition and the assumption of perfect oversight by all economic agents. Building on the Rectangular-Choice-of-Technology (RCOT) model, this study proposes a new modeling approach for CLCA, the Technology Choice Model (TCM). In this approach, the RCOT model is adapted for its use in CLCA and extended to incorporate parameter uncertainties and suboptimal decisions due to market imperfections and information asymmetry in a stochastic setting. In a case study on rice production, we demonstrate that the proposed approach allows modeling of complex production technology mixes and their expected environmental outcomes under uncertainty, at a high level of detail. Incorporating the effect of production constraints, uncertainty, and suboptimal decisions by economic agents significantly affects technology mixes and associated greenhouse gas (GHG) emissions of the system under study. The case study also shows the model's ability to determine both the average and marginal environmental impacts of a product in response to changes in the quantity of final demand.

  7. Information technologies for global resources management and environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A.P.; Wang, Hua.

    1992-01-01

    Recent advances in computer and communications technologies offer unprecedented opportunities to develop sophisticated information resources management systems for global resources management and environment assessment in an efficient, effective, and systematic manner. In this paper, the emerging global energy and environmental issues are identified. Since satellite-based remote sensing systems are becoming increasingly available and produce massive data collections, the utilization of imaging processing techniques and their applications for regional and global resources management and environmental studies are described. Interoperability and interconnectivity among heterogeneous computer systems are major issues in designing a totally integrated, multimedia-based, information resources management system that operates in a networking environment. Discussions of the future technology trends are focused on a number of emerging information management technologies and communications standards which will aid in achieving seamless system integration and offer user-friendly operations. It can be foreseen that advances in computer and communications technologies, increasingly sophisticated image processing techniques and Geographical Information Systems (GIS), and the development of globally comprehensive data bases will bring global visualization'' onto multimedia desktop computers before the end of this decade.

  8. Information technologies for global resources management and environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A.P.; Wang, Hua

    1992-09-01

    Recent advances in computer and communications technologies offer unprecedented opportunities to develop sophisticated information resources management systems for global resources management and environment assessment in an efficient, effective, and systematic manner. In this paper, the emerging global energy and environmental issues are identified. Since satellite-based remote sensing systems are becoming increasingly available and produce massive data collections, the utilization of imaging processing techniques and their applications for regional and global resources management and environmental studies are described. Interoperability and interconnectivity among heterogeneous computer systems are major issues in designing a totally integrated, multimedia-based, information resources management system that operates in a networking environment. Discussions of the future technology trends are focused on a number of emerging information management technologies and communications standards which will aid in achieving seamless system integration and offer user-friendly operations. It can be foreseen that advances in computer and communications technologies, increasingly sophisticated image processing techniques and Geographical Information Systems (GIS), and the development of globally comprehensive data bases will bring ``global visualization`` onto multimedia desktop computers before the end of this decade.

  9. A Framework for Assessment of Aviation Safety Technology Portfolios

    Science.gov (United States)

    Jones, Sharon M.; Reveley, Mary S.

    2014-01-01

    The programs within NASA's Aeronautics Research Mission Directorate (ARMD) conduct research and development to improve the national air transportation system so that Americans can travel as safely as possible. NASA aviation safety systems analysis personnel support various levels of ARMD management in their fulfillment of system analysis and technology prioritization as defined in the agency's program and project requirements. This paper provides a framework for the assessment of aviation safety research and technology portfolios that includes metrics such as projected impact on current and future safety, technical development risk and implementation risk. The paper also contains methods for presenting portfolio analysis and aviation safety Bayesian Belief Network (BBN) output results to management using bubble charts and quantitative decision analysis techniques.

  10. Finding Qualitative Research Evidence for Health Technology Assessment.

    Science.gov (United States)

    DeJean, Deirdre; Giacomini, Mita; Simeonov, Dorina; Smith, Andrea

    2016-08-01

    Health technology assessment (HTA) agencies increasingly use reviews of qualitative research as evidence for evaluating social, experiential, and ethical aspects of health technologies. We systematically searched three bibliographic databases (MEDLINE, CINAHL, and Social Science Citation Index [SSCI]) using published search filters or "hedges" and our hybrid filter to identify qualitative research studies pertaining to chronic obstructive pulmonary disease and early breast cancer. The search filters were compared in terms of sensitivity, specificity, and precision. Our screening by title and abstract revealed that qualitative research constituted only slightly more than 1% of all published research on each health topic. The performance of the published search filters varied greatly across topics and databases. Compared with existing search filters, our hybrid filter demonstrated a consistently high sensitivity across databases and topics, and minimized the resource-intensive process of sifting through false positives. We identify opportunities for qualitative health researchers to improve the uptake of qualitative research into evidence-informed policy making.

  11. Health technology assessment in Australia: a role for clinical registries?

    Science.gov (United States)

    Scott, Anna Mae

    2016-03-31

    Objective Health technology assessment (HTA) is a process of assessing evidence to inform policy decisions about public subsidy of new drugs and medical procedures. Where evidence is uncertain but the technology itself is promising, funders may recommend funding on an interim basis. It is unknown whether evidence from clinical registries is used to resolve uncertainties identified in interim-funded decisions made by Australian HTA bodies. Therefore, the present study evaluated the role of evidence from clinical registries in resolving evidence uncertainties identified by the Medical Services Advisory Committee (MSAC).Methods All HTAs considered by MSAC between 1998 and 2015 were reviewed and assessments that recommended interim funding were identified. The MSAC website was searched to identify reassessments of these recommendations and sources of evidence used to resolve the uncertainties were identified.Results Of 173 HTA reports considered by MSAC, 17 (10%) contained an interim funding recommendation. Eight recommendations cited uncertainty around safety, 15 cited uncertainty around clinical effectiveness and 13 cited uncertainty around economics (cost-effectiveness and/or budget impact). Of the 17 interim funding recommendations, 11 (65%) have been reassessed. Only two reassessments relied on clinical registry evidence to resolve evidence gaps identified at the time of the interim funding recommendation.Conclusions Clinical registries are underused as a source of evidence for resolving uncertainties around promising new health technologies in Australia. An open dialogue between stakeholders on the role of registries in this context is needed.What is known about the topic? HTA is a process of assessing the evidence to inform policy decisions about public subsidy of new health technologies (e.g. pharmaceuticals, diagnostic tests, medical procedures). Where evidence is uncertain but the technology under evaluation is promising, funders may recommend the funding of

  12. The Health Technology Assessment of companion diagnostics: experience of NICE.

    Science.gov (United States)

    Byron, Sarah K; Crabb, Nick; George, Elisabeth; Marlow, Mirella; Newland, Adrian

    2014-03-15

    Companion diagnostics are used to aid clinical decision making to identify patients who are most likely to respond to treatment. They are becoming increasingly important as more new pharmaceuticals receive licensed indications that require the use of a companion diagnostic to identify the appropriate patient subgroup for treatment. These pharmaceuticals have proven benefit in the treatment of some cancers and other diseases, and also have potential to precisely tailor treatments to the individual in the future. However, the increasing use of companion diagnostics could place a substantial burden on health system resources to provide potentially high volumes of testing. This situation, in part, has led policy makers and Health Technology Assessment (HTA) bodies to review the policies and methods used to make reimbursement decisions for pharmaceuticals requiring companion diagnostics. The assessment of a pharmaceutical alongside the companion diagnostic used in the clinical trials may be relatively straightforward, although there are a number of challenges associated with assessing pharmaceuticals where a range of alternative companion diagnostics are available for use in routine clinical practice. The UK HTA body, the National Institute for Health and Care Excellence (NICE), has developed policy for considering companion diagnostics using its Technology Appraisal and Diagnostics Assessment Programs. Some HTA bodies in other countries have also adapted their policies and methods to accommodate the assessment of companion diagnostics. Here, we provide insight into the HTA of companion diagnostics for reimbursement decisions and how the associated challenges are being addressed, in particular by NICE. See all articles in this CCR Focus section, "The Precision Medicine Conundrum: Approaches to Companion Diagnostic Co-development."

  13. Quality assurance and technology assessment: pieces of a larger puzzle.

    Science.gov (United States)

    McDonald, I G

    2000-01-01

    Increasing integration of health care and health services research has resulted in an overlap between disciplines involved in the evaluation of clinical practice. We have examined the relationships of quality assurance (QA), medical technology assessment (TA), clinical epidemiology (CE) and evidence-based medicine (EBM) from an historical perspective. Clinicians, patients and administrators need local information on effectiveness of routine care. Information from trials alone, efficacy data, will not suffice nor can it be culled from administrative databases designed for other purposes. The current activities of QA should be therefore be expanded to include the study of the effectiveness of interventions in terms of appropriateness of use, patient outcomes and study of the determinants of outcomes, as seen from the perspective of doctors, patients, administrators and policy makers, using data collected during the course of routine patient care. With the assistance of information technology, with methodological support and multidisciplinary cooperation, clinicians can do this as part of a more broadly defined clinical research. Quality assurance and TA both evolved with the objective of studying clinical care but have quite different historical roots, complementary perspectives and objectives, use different methods and involve a different set of practitioners. Quality assurance is a type of 'formative' evaluation conducted in the clinical setting using indicators as flags of process or outcome events of interest, simple surveys and audit studies. Its primary aim is to achieve incremental improvement rather than to simply pass judgement. An important underlying assumption is that health care behaves as a complex dynamic system. Technology assessment, a form of summative evaluation with an orientation towards policy, synthesises information from formal scientific studies of efficacy in the form of clinical trials and studies of cost-effectiveness. For the evaluation

  14. Historical development of health technology assessment in Thailand.

    Science.gov (United States)

    Teerawattananon, Yot; Tantivess, Sripen; Yothasamut, Jomkwan; Kingkaew, Pritaporn; Chaisiri, Kakanang

    2009-07-01

    This study aims to review the development of health technology assessment (HTA), including the socioeconomic context, outputs, and policy utilization in the Thai setting. This study was conducted through extensive document reviews including these published in both domestic and international literature. Evidence suggests that contextual elements of the health system, especially the country's economic status and health financing reforms, as well as their effects on government budgeting for medical and public health services, played an important role in the increasing needs and demands for HTA information among policy makers. In the midst of substantial economic growth during the years 1982 to 1996, several studies reported the rapid diffusion and poor distribution of health technologies, and inequitable access to high-cost technology in public and private hospitals. At the same time, economic analysis and its underpinning concept of efficiency were suggested by groups of scholars and health officials to guide national policy on the investment in health technology equipment. Related research and training programs were subsequently launched. However, none of these HTA units could be institutionalized into national bodies. From 1997 to 2005, an economic recession, followed by the introduction of a universal health coverage plan, triggered the demands for effective measures for cost containment and prioritization of health interventions. This made policy makers and researchers at the Ministry of Public Health (MOPH) pay increasing attention to economic appraisals, and several HTA programs were established in the Ministry. Despite the rising number of Thai health economic publications, a major problem at that period involved the poor quality of studies. Since 2006, economic recovery and demands from different interests to include expensive technologies in the public health benefit package have been crucial factors promoting the role of HTA in national policy decisions

  15. Technology assessment of applied techniques for exploitation of geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    1977-04-01

    Studies were made to elucidate the effects of technological development of natural steam and hot water on the general social and industrial environments. These were followed by studies of enhanced methods for the forecasting of these impacts. The studies included assessments of actual conditions and the preparation of regional models, ranging from rural to urban-fringe situations. The economic implications of geothermal development in various regional situations are discussed, and the models developed provide for the integration of new data and their extrapolation to as yet uncertain situations.

  16. An OTA-C filter for ECG acquisition systems with highly linear range and less passband attenuation

    Science.gov (United States)

    Jihai, Duan; Chuang, Lan; Weilin, Xu; Baolin, Wei

    2015-05-01

    A fifth order operational transconductance amplifier-C (OTA-C) Butterworth type low-pass filter with highly linear range and less passband attenuation is presented for wearable bio-telemetry monitoring applications in a UWB wireless body area network. The source degeneration structure applied in typical small transconductance circuit is improved to provide a highly linear range for the OTA-C filter. Moreover, to reduce the passband attenuation of the filter, a cascode structure is employed as the output stage of the OTA. The OTA-based circuit is operated in weak inversion due to strict power limitation in the biomedical chip. The filter is fabricated in a SMIC 0.18-μm CMOS process. The measured results for the filter have shown a passband gain of -6.2 dB, while the -3-dB frequency is around 276 Hz. For the 0.8 VPP sinusoidal input at 100 Hz, a total harmonic distortion (THD) of -56.8 dB is obtained. An electrocardiogram signal with noise interference is fed into this chip to validate the function of the designed filter. Project supported by the National Natural Science Foundation of China (Nos. 61161003, 61264001, 61166004) and the Guangxi Natural Science Foundation (No. 2013GXNSFAA019333).

  17. Impact of Non-Idealities System on Spatial Correlation in a Multi-Probe Based MIMO OTA Setup

    DEFF Research Database (Denmark)

    Fan, Wei; Nielsen, Jesper Ødum; Carreño, Xavier

    2013-01-01

    . This paper investigates the extent to which we can emulate the channel spatial characteristics inside the test zone where the device under test is located. The focus is on performance deterioration introduced by system non-idealities on spatial correlation emulation in practical MIMO OTA test systems....

  18. Thinking Tools in Computer-Based Assessment: Technology Enhancements in Assessments for Learning

    Science.gov (United States)

    Rosen, Yigal

    2014-01-01

    One of the greatest concerns in schools today is how teachers can bring together assessment and learning in a way that is meaningful for students' thinking skills, while focusing on content standards. Better understanding of how different types of technology based thinking tools can be used for improving classroom teaching and learning,…

  19. Available technology for indirect conversion of coal to methanol and gasoline: a technology and economics assessment. [Technology assessment and comparative evaluation of available processes

    Energy Technology Data Exchange (ETDEWEB)

    Wham, R. M.; Forrester, III, R. C.

    1980-01-01

    The objective of the work was to review and assess the present state of the art of indirect liquid fuels synthesis, with particular emphasis to be placed upon those processes which produce methanol suitable for use as fuel. Following this review, four conceptual designs for indirect conversion of a Western subbituminous coal to methanol and gasoline were prepared. Capital and operating costs for each of the four cases were then estimated. This information was used to calculate the required product selling prices under a base case set of financial ground rules. Results of the methanol production technology assessment and economic assessments of four coal conversion plants are presented.

  20. Waiting for Disasters: A Risk Reduction Assessment of Technological Disasters

    Science.gov (United States)

    Rovins, Jane; Winningham, Sam

    2010-05-01

    This session provides a risk reduction/mitigation assessment of natural hazards causation of technological disasters and possible solution. People use technology in an attempt to not only control their environment but nature itself in order to make them feel safe and productive. Most strategies for managing hazards followed a traditional planning model i.e. study the problem, identify and implement a solution, and move on to the next problem. This approach is often viewed as static model and risk reduction is more of an upward, positive, linear trend. However, technological disasters do not allow risk reduction action to neatly fit this upward, positive, linear trend with actual or potential threats to the environment and society. There are different types of technological disasters, including industrial accidents; pipeline ruptures; accidents at power, water and heat supply systems and other lines of communication; sudden collapse of buildings and mines; air crashes; shipwrecks; automobile and railway accidents to name a few. Natural factors can play an essential role in triggering or magnifying technological disasters. They can result from the direct destruction of given technical objects by a hazardous natural process such as the destruction of an atomic power plant or chemical plant due to an earthquake. Other examples would include the destruction of communications or infrastructure systems by heavy snowfalls, strong winds, avalanches. Events in the past ten years clearly demonstrate that natural disasters and the technological disasters that accompany them are not problems that can be solved in isolation and risk reduction can play an important part. Risk reduction was designed to head off the continuing rising financial and structural tolls from disasters. All Hazard Risk Reduction planning was supposed to include not only natural, but technological, and human-made disasters as well. The subsequent disaster risk reduction (DRR) indicators were to provide the

  1. Offline Chinese handwriting recognition :an assessment of current technology

    Institute of Scientific and Technical Information of China (English)

    Sargur N.Srihari; Xuanshen Yang; Gregory R.Ball

    2007-01-01

    Offline Chinese handwriting recognition (OCHR)is a typically difficult pattern recognition problem.Many authors have presented various approaches to recognizing its different aspects.We present a survey and an assessment of relevant papers appearing in recent publications of relevant conferences and journals,including those appearing in ICDAR,SDIUT,IWFHR,ICPR,PAMI,PR,PRL,SPIE-DRR,and IJDAR.The methods are assessed in the sense that we document their technical approaches,strengths,and weaknesses,as well as the data sets on which they were reportedly tested and on which results were generated.We also identify a list of technology gaps with respect to Chinese handwriting recognition and identify technical approaches that show promise in these areas as well as identify the leading researchers for the applicable topics,discussing difficulties associated with any given approach.

  2. Health Technology Assessment of Magnetic Resonance Imaging in Shanxi Province

    Institute of Scientific and Technical Information of China (English)

    Yueze Liu; Jianwen Cao; Zuxun Lu

    2004-01-01

    Assess the current status of MRI in Shanxi province by health technology assessment method to provide suggestion and guidelines for future government decisions on the procurement and installation of new high-tech medical equipments. All of the 21 hospitals installed MRIs were surveyed.The results showed that 1 ) Diffusion of MRI is consistent with the economic development in different regional districts and hospital levels in Shanxi province. 2) There are better monetary returns of MRI in higher level hospitals than lower level hospitals. 3) Most MRIs in Shanxi province had been running at a loss, and the first class tertiary level hospitals had been making profit from providing MRI services to patients. 4) Better cost-benefit accorded with higher hospital level, more patients serviced etc. 5 ) The biggest investment risk is the initial purchase and installation of MRI. 6) Positive rates and veracity of MRI diagnosis were higher. 7) MRI is a safe equipment.

  3. Simulation Technology Laboratory Building 970 hazards assessment document

    Energy Technology Data Exchange (ETDEWEB)

    Wood, C.L.; Starr, M.D.

    1994-11-01

    The Department of Energy Order 5500.3A requires facility-specific hazards assessments be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with the Simulation Technology Laboratory, Building 970. The entire inventory was screened according to the potential airborne impact to onsite and offsite individuals. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distances at which a postulated facility event will produce consequences exceeding the ERPG-2 and Early Severe Health Effects thresholds are 78 and 46 meters, respectively. The highest emergency classification is a Site Area Emergency. The Emergency Planning Zone is 100 meters.

  4. Radiation safety assessment and development of environmental radiation monitoring technology

    CERN Document Server

    Choi, B H; Kim, S G

    2002-01-01

    The Periodic Safety Review(PSR) of the existing nuclear power plants is required every ten years according to the recently revised atomic energy acts. The PSR of Kori unit 1 and Wolsong unit 1 that have been operating more than ten years is ongoing to comply the regulations. This research project started to develop the techniques necessary for the PSR. The project developed the following four techniques at the first stage for the environmental assessment of the existing plants. 1) Establishment of the assessment technology for contamination and accumulation trends of radionuclides, 2) alarm point setting of environmental radiation monitoring system, 3) Development of Radiation Safety Evaluation Factor for Korean NPP, and 4) the evaluation of radiation monitoring system performance and set-up of alarm/warn set point. A dynamic compartment model to derive a relationship between the release rates of gas phase radionuclides and the concentrations in the environmental samples. The model was validated by comparing ...

  5. GENERALIZED NON INFLAMMATORY SCLERAL THINNING IN A CASE NAEVUS OF OTA

    Directory of Open Access Journals (Sweden)

    Nita

    2015-07-01

    Full Text Available A 30 year old female patient came with redness, pain and watering in her left eye since five days. Past history included sudden loss of vision in right eye two years back following birth of a stillborn ba by due to preeclampsia. On examination she had hyperpigmentation of the face and neck. Both the eyes showed patchy hyperpigmentation all around the limbus. Right eye showed 10 degrees of exotropia with afferent pupillary defect. Intraocular pressure was ra ised to 29 mm of Hg. The Right disc C/D ratio was 0.7 with pallor. The left eye showed signs & symptoms suggestive of acute iridocyclitis with normal IOP. Left visual acuity had dropped to 20/60. Further investigation confirmed the patient had generalised non inflammatory scleral thinning on UBM and associated conductive hearing loss. This is therefore an unusual case of Nevus of ota/Ito.

  6. Analysis of non-rainy attenuation on earth-space path in Ota, Southwest Nigeria

    Science.gov (United States)

    Omotosho, T. V.; Akinwumi, S. A.; Usikalu, M. R.; Ometan, O. O.; Adewusi, M. O.; Abdullah, M.

    2017-05-01

    Propagation effects due to atmospheric gases and tropospheric scintillation requires accurate modelling in the design of satellite communication systems. The combination of the two attenuation phenomena was observed within the period of August 2014 to December 2015. The result of this paper presents the on-going observation and data analysis of non-rainy attenuation on earth-space path in Ota, Southwest Nigeria. Results of clear-sky attenuation vary between 0 dBm and 4.85 dBm in January and February 2015 respectively. While a value of 4.23 dBm and 4.75 dBm were observed in October 2014 and 2015 respectively. The results will be useful for satellite communication system design and will be submitted to ITU-R Study group 3 Databank.

  7. A scientific assessment of a new technology orbital telescope

    Science.gov (United States)

    1995-01-01

    As part of a program designed to test the Alpha chemical laser weapons system in space, the Ballistic Missile Defense Organization (BMDO) developed components of an agile, lightweight, 4-meter telescope, equipped with an advanced active-optics system. BMDO had proposed to make space available in the telescope's focal plane for instrumentation optimized for scientific applications in astrophysics and planetary astronomy for a potential flight mission. Such a flight mission could be undertaken if new or additional sponsorship can be found. Despite this uncertainty, BMDO requested assistance in defining the instrumentation and other design aspects necessary to enhance the scientific value of a pointing and tracking mission. In response to this request, the Space Studies Board established the Task Group on BMDO New Technology Orbital Observatory (TGBNTOO) and charged it to: (1) provide instrumentation, data management, and science-operations advice to BMDO to optimize the scientific value of a 4-meter mission; and (2) support a space studies board assessment of the relative scientific merit of the program. This report deals with the first of these tasks, assisting the Advanced Technology Demonstrator's (ATD's) program scientific potential. Given the potential scientific aspects of the 4-meter telescope, this project is referred to as the New Technology Orbital Telescope (NTOT), or as the ATD/NTOT, to emphasize its dual-use character. The task group's basic conclusion is that the ATD/NTOT mission does have the potential for contributing in a major way to astronomical goals.

  8. Why ethics should be part of health technology assessment.

    Science.gov (United States)

    Hofmann, Bjørn Morten

    2008-01-01

    From the heydays of HTA in the 1970s, it has been argued that ethics should be a part of HTA. Despite more than 30 years with repeated intentions, only few HTA reports include ethical analysis, and there is little agreement on methods for integrating ethics. This poses the question of why it is so important to integrate ethics in HTA? The article analyzes ten arguments for making ethics part of HTA. The validity of the arguments depend on what we mean by "integrating," "ethics," and "HTA." Some of the counterarguments explain why it has taken so long to integrate ethics in HTA and why there are so many ethical approaches. Nevertheless, some of the arguments for making ethics part of HTA appear to be compelling. Health care is a moral endeavor, and the vast potential of technology poses complex moral challenges. A thorough assessment of technology would include reflection on these moral aspects. Ethics provides such a moral reflection. Health technology is a way to improve the life of human individuals. This involves questions of what "the good life" is, and hence ethical issues. Trying to ignore such questions may inflict with the moral foundation of health care: to help people. Additionally, HTA is an evaluation, and as such also a reflection on values. Hence, there is a profound affinity between HTA and ethics. Accordingly, ethics cannot be "integrated" in HTA as ethics is already a constitutive part of HTA. However, ethics can be acknowledged and emphasized.

  9. Technology-Enhanced Formative Assessment: A Research-Based Pedagogy for Teaching Science with Classroom Response Technology

    Science.gov (United States)

    Beatty, Ian D.; Gerace, William J.

    2009-01-01

    "Classroom response systems" (CRSs) are a promising instructional technology, but most literature on CRS use fails to distinguish between technology and pedagogy, to define and justify a pedagogical perspective, or to discriminate between pedagogies. "Technology-enhanced formative assessment" (TEFA) is our pedagogy for CRS-based science…

  10. Evaluation of Policy and Research Interventions in Science and Technology: Consequence Assessment of Regulatory and Technology Transfer Programs

    Science.gov (United States)

    Dias, Mary Beatrice

    2011-01-01

    This research contributes to efforts in assessment studies related to science and technology interventions. The work presented in this thesis focuses on understanding the effects of policies that influence science and technology interventions, and determining the impact of science and technology interventions themselves. Chapter 1 explores how…

  11. A short history of health technology assessment in Germany.

    Science.gov (United States)

    Perleth, Matthias; Gibis, Bernhard; Göhlen, Britta

    2009-07-01

    To provide an overview of the development of health technology assessment (HTA) in Germany since the 1990s. Analysis of key documents (e.g. literature, laws, and other official documentation) and personal experiences. Health technology assessment (HTA) entered the political agenda in Germany only in the mid-1990s, basically as the result of a top-down approach toward more efficiency in health care, but with a strong impetus of an evidence-based medicine movement. Accordingly, HTA became part of several healthcare reform laws since 1997, which led to the establishment of the Federal Joint Committee (G-BA) and the Institute for Quality and Efficiency in Health Care (IQWiG) in 2004. This tandem construction aims at using evidence in decision-making processes for coverage and other decisions. These developments have led to a considerable impact of HTA in Germany. In addition, a broad spectrum of activities at universities and in other organizations, such as the German Institute for Medical Documentation and Information (DIMDI), can be observed that contribute to both teaching and research in HTA. German researchers in the field of HTA are actively involved in international projects, such as EUNetHTA, and contribute to scientific conferences and journals.

  12. Meat Quality Assessment by Electronic Nose (Machine Olfaction Technology

    Directory of Open Access Journals (Sweden)

    Sundar Balasubramanian

    2009-07-01

    Full Text Available Over the last twenty years, newly developed chemical sensor systems (so called “electronic noses” have made odor analyses possible. These systems involve various types of electronic chemical gas sensors with partial specificity, as well as suitable statistical methods enabling the recognition of complex odors. As commercial instruments have become available, a substantial increase in research into the application of electronic noses in the evaluation of volatile compounds in food, cosmetic and other items of everyday life is observed. At present, the commercial gas sensor technologies comprise metal oxide semiconductors, metal oxide semiconductor field effect transistors, organic conducting polymers, and piezoelectric crystal sensors. Further sensors based on fibreoptic, electrochemical and bi-metal principles are still in the developmental stage. Statistical analysis techniques range from simple graphical evaluation to multivariate analysis such as artificial neural network and radial basis function. The introduction of electronic noses into the area of food is envisaged for quality control, process monitoring, freshness evaluation, shelf-life investigation and authenticity assessment. Considerable work has already been carried out on meat, grains, coffee, mushrooms, cheese, sugar, fish, beer and other beverages, as well as on the odor quality evaluation of food packaging material. This paper describes the applications of these systems for meat quality assessment, where fast detection methods are essential for appropriate product management. The results suggest the possibility of using this new technology in meat handling.

  13. Differences among formulary submission guidelines: implications for health technology assessment.

    Science.gov (United States)

    Mauskopf, Josephine; Walter, Jeffrey; Birt, Julie; Bowman, Lee; Copley-Merriman, Catherine; Drummond, Michael

    2011-07-01

    This article provides a detailed understanding of the differences in selected formulary submission guidelines supplied by various health technology assessment (HTA) agencies and indicates how these differences can impact the evidence base used to populate the HTA. Detailed summaries of the recommended methods for evidence generation, organized by topic areas relevant for clinical and economic data, for twelve countries in Europe, North America, and Australia where HTA processes are well developed were prepared. Using these summaries, we provide examples of the likely impact these differences in recommended methods could have on the evidence base used to evaluate new health technologies. Areas where recommendations differed included methodologies for systematic literature reviews (e.g., preferred databases and study designs for inclusion); selection of appropriate comparators; guidance on critical appraisal and synthesis of clinical evidence; appropriate sources for health value measures, resource use, and cost data; and approaches to uncertainty analyses. Performing literature searches that capture all relevant studies and then creating subsets of the literature based on a listing of country-specific requirements could allow for direct comparison of the evidence bases associated with the different guidelines. If the formulary submission guidelines were followed as written, different (although overlapping) bodies of evidence likely would be generated for each country, which could contribute to disparate assessments and recommendations. This comparison of the formulary submission guidelines could contribute to an understanding of why clinical and reimbursement decisions vary across countries.

  14. Open reduction and internal fixation of OTA type C2-C4 fractures of the calcaneus with a triple-plate technique.

    Science.gov (United States)

    Brunner, Alexander; Müller, Jochen; Regazzoni, Pietro; Babst, Reto

    2012-01-01

    The purpose of this study was to present a surgical technique of open reduction and internal fixation of displaced intra-articular calcaneal fractures with 3 AO mini-fragment plates and to evaluate the clinical and radiological outcome of a consecutive group of patients after a mean follow-up of 41.7 months. A series of 54 patients (16 women and 38 men) with 62 calcaneal fractures were treated over a period of 6.5 years. Forty-five patients with 50 calcaneal fractures were completely clinically and radiologically followed up. Clinical follow-up included assessment of range of motion, pain according to a visual analogue scale, the American Orthopaedic Foot and Ankle Society hindfoot score, and the short-form 36 health survey. Radiological follow-up included plain axial and lateral radiographs and measurement of the Böhler's angle and Gissane's angle. Independent Student's t test and paired Student's t test were used alongside the chi-square test to compare clinical and radiological data and score values between different groups of patients. Eleven patients showed breakage of the osteosynthesis material during the healing process and 2 patients sustained deep wound infection requiring revision surgery. At the final follow-up all fractures had healed. The average range of motion was supination 26.4° (range 0° to 50°; SD 11.6°), pronation 15.4° (range 0° to 30°; SD 6.4°), dorsal extension 14.3° (range -10° to 30°; SD 8.0°), and plantarflexion 39.6° (range 20° to 65°; SD 11.7°). Patients with OTA type C4 fractures achieved significantly lower supination (p fracture types. The mean visual analog scale pain score was 3.6 (range 0 to 8; SD 2.3) points, average American Orthopaedic Foot and Ankle Society hindfoot score was 70.8 (range 33 to 100; SD 17.1) points, and the mean short-form 36 score was 60.98 (range 22.9 to 93.0; SD 18.4) points. The mean postoperative Böhler's angle was 28.9° (range 8° to 38°; SD 7.1°), which decreased to 23.6° (range 4

  15. Technology and Economic Assessment of Innovative Field Drainage Technologies in Denmark

    DEFF Research Database (Denmark)

    Gachango, Florence Gathoni

    Intensive agricultural production in most parts of the world especially in the more developed countries continues to mount pressure on water resources thereby threatening the quality of life in the aquatic ecosystems. With stringent standards such as those stipulated in the European Union Water...... proposed as appropriate solutions to this problem in the Danish context. The feasibility of these technologies with regards to their cost-effectiveness in nutrient mitigation, farmers’ adoption behavior, and environmental policy implementation is assessed in this thesis. The thesis comprises of four papers...... based on survey and case-farms data and utilizes a mix of quantitative and qualitative methods to investigate: i) the farmers’ perception of water quality and their adoption behavior with respect to voluntary nutrient reduction technologies, ii) the farmers willingness to adopt constructed wetland...

  16. Virtues, ecological momentary assessment/intervention and smartphone technology.

    Science.gov (United States)

    Runyan, Jason D; Steinke, Ellen G

    2015-01-01

    Virtues, broadly understood as stable and robust dispositions for certain responses across morally relevant situations, have been a growing topic of interest in psychology. A central topic of discussion has been whether studies showing that situations can strongly influence our responses provide evidence against the existence of virtues (as a kind of stable and robust disposition). In this review, we examine reasons for thinking that the prevailing methods for examining situational influences are limited in their ability to test dispositional stability and robustness; or, then, whether virtues exist. We make the case that these limitations can be addressed by aggregating repeated, cross-situational assessments of environmental, psychological and physiological variables within everyday life-a form of assessment often called ecological momentary assessment (EMA, or experience sampling). We, then, examine how advances in smartphone application (app) technology, and their mass adoption, make these mobile devices an unprecedented vehicle for EMA and, thus, the psychological study of virtue. We, additionally, examine how smartphones might be used for virtue development by promoting changes in thought and behavior within daily life; a technique often called ecological momentary intervention (EMI). While EMA/I have become widely employed since the 1980s for the purposes of understanding and promoting change amongst clinical populations, few EMA/I studies have been devoted to understanding or promoting virtues within non-clinical populations. Further, most EMA/I studies have relied on journaling, PDAs, phone calls and/or text messaging systems. We explore how smartphone app technology provides a means of making EMA a more robust psychological method, EMI a more robust way of promoting positive change, and, as a result, opens up new possibilities for studying and promoting virtues.

  17. Virtues, Ecological Momentary Assessment/Intervention and Smartphone Technology

    Directory of Open Access Journals (Sweden)

    Jason D Runyan

    2015-05-01

    Full Text Available Virtues, generally understood as stable and robust dispositions for certain responses across morally relevant situations, have been a growing topic of interest in psychology. A central topic of discussion has been whether the existence of virtues (as a kind of stable and robust disposition is called into question by studies showing that, to a significant degree, an individual’s situation can influence their responses. In this review, we examine reasons for thinking that these kinds of situational studies are limited in their ability to test dispositional stability and robustness; or, then, whether virtues exist. We make the case that these limitations can be addressed by aggregating repeated, cross-situational assessments of environmental, psychological and physiological variables within everyday life—a form of assessment often called ecological momentary assessment (EMA, or experience sampling. We, then, examine how advances in smartphone application (app technology, and their mass adoption, make these mobile devices an unprecedented vehicle for EMA and, thus, the psychological study of virtue. We, additionally, examine how smartphones might be used for virtue development by promoting changes in thought and behavior within daily life; a technique often called ecological momentary intervention (EMI. While EMA/I have become widely employed since the 1980s for the purposes of understanding and promoting change amongst clinical populations, few EMA/I studies have been devoted to understanding or promoting virtues within non-clinical populations. Further, most EMA/I studies have relied on journaling, PDAs, phone calls and/or text messaging systems. We explore how smartphone app technology provides a means of making EMA a more robust psychological method, EMI a more robust way of promoting positive change, and, as a result, opens up new possibilities for studying and promoting virtues.

  18. Cost, Time, and Risk Assessment of Different Wave Energy Converter Technology Development Trajectories: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Jochem W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Laird, Daniel [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Costello, Ronan [Wave Venture; Roberts, Jesse [Sandia National Laboratories; Bull, Diana [Sandia National Laboratories; Babarit, Aurelien [Ecole Centrale de Nantes; Nielsen, Kim [Ramboll; Ferreira, Claudio Bittencourt [DNV-GL; Kennedy, Ben [Wave Venture

    2017-09-14

    This paper presents a comparative assessment of three fundamentally different wave energy converter technology development trajectories. The three technology development trajectories are expressed and visualised as a function of technology readiness levels and technology performance levels. The assessment shows that development trajectories that initially prioritize technology readiness over technology performance are likely to require twice the development time, consume a threefold of the development cost, and are prone to a risk of technical or commercial failure of one order of magnitude higher than those development trajectories that initially prioritize technology performance over technology readiness.

  19. Assessment vs. appraisal of ethical aspects of health technology assessment: can the distinction be upheld?

    Science.gov (United States)

    Sandman, Lars; Heintz, Emelie

    2014-01-01

    An essential component of health technology assessment (HTA) is the assessment of ethical aspects. In some healthcare contexts, tasks are strictly relegated to different expert groups: the HTA-agencies are limited to assessment of the technology and other actors within the health care sector are responsible for appraisal and recommendations. Ethical aspects of health technologies are considered with reference to values or norms in such a way that may be prescriptive, or offer guidance as to how to act or relate to the issue in question. Given this internal prescriptivity, the distinction between assessment and appraisal seems difficult to uphold, unless the scrutiny stops short of a full ethical analysis of the technology. In the present article we analyse the distinction between assessment and appraisal, using as an example ethical aspects of implementation of GPS-bracelets for people with dementia. It is concluded that for HTA-agencies with a strictly delineated assessment role, the question of how to deal with the internal prescriptivity of ethics may be confusing. A full ethical analysis might result in a definite conclusion as to whether the technology in question is ethically acceptable or not, thereby limiting choices for decision-makers, who are required to uphold certain ethical values and norms. At the same time, depending on the exact nature of such a conclusion, different action strategies can be supported. A positive appraisal within HTA could result in a decision on mandatory implementation, or funding of the technology, thereby making it available to patients, or decisions to allow and even encourage the use of the technology (even if someone else will have to fund it). A neutral appraisal, giving no definite answer as to whether implementation is recommended or not, could result in a laissez-faire attitude towards the technology. A negative appraisal could result in a decision to discourage or even prohibit implementation. This paper presents an

  20. Assessment vs. appraisal of ethical aspects of health technology assessment: can the distinction be upheld?

    Directory of Open Access Journals (Sweden)

    Sandman, Lars

    2014-11-01

    Full Text Available [english] An essential component of health technology assessment (HTA is the assessment of ethical aspects. In some healthcare contexts, tasks are strictly relegated to different expert groups: the HTA-agencies are limited to assessment of the technology and other actors within the health care sector are responsible for appraisal and recommendations. Ethical aspects of health technologies are considered with reference to values or norms in such a way that may be prescriptive, or offer guidance as to how to act or relate to the issue in question. Given this internal prescriptivity, the distinction between assessment and appraisal seems difficult to uphold, unless the scrutiny stops short of a full ethical analysis of the technology. In the present article we analyse the distinction between assessment and appraisal, using as an example ethical aspects of implementation of GPS-bracelets for people with dementia. It is concluded that for HTA-agencies with a strictly delineated assessment role, the question of how to deal with the internal prescriptivity of ethics may be confusing. A full ethical analysis might result in a definite conclusion as to whether the technology in question is ethically acceptable or not, thereby limiting choices for decision-makers, who are required to uphold certain ethical values and norms. At the same time, depending on the exact nature of such a conclusion, different action strategies can be supported. A positive appraisal within HTA could result in a decision on implementation, or of the technology, thereby making it available to patients, or decisions to and even the use of the technology (even if someone else will have to fund it. A neutral appraisal, giving no definite answer as to whether implementation is recommended or not, could result in a towards the technology. A negative appraisal could result in a decision to or even implementation. This paper presents an overview of the implications of different outcomes

  1. Scenario drafting to anticipate future developments in technology assessment

    Directory of Open Access Journals (Sweden)

    Retèl Valesca P

    2012-08-01

    Full Text Available Abstract Background Health Technology Assessment (HTA information, and in particular cost-effectiveness data is needed to guide decisions, preferably already in early stages of technological development. However, at that moment there is usually a high degree of uncertainty, because evidence is limited and different development paths are still possible. We developed a multi-parameter framework to assess dynamic aspects of a technology -still in development-, by means of scenario drafting to determine the effects, costs and cost-effectiveness of possible future diffusion patterns. Secondly, we explored the value of this method on the case of the clinical implementation of the 70-gene signature for breast cancer, a gene expression profile for selecting patients who will benefit most from chemotherapy. Methods To incorporate process-uncertainty, ten possible scenarios regarding the introduction of the 70-gene signature were drafted with European experts. Out of 5 most likely scenarios, 3 drivers of diffusion (non-compliance, technical failure, and uptake were quantitatively integrated in a decision-analytical model. For these scenarios, the cost-effectiveness of the 70-gene signature expressed in Incremental Cost-Effectiveness Ratios (ICERs was compared to clinical guidelines, calculated from the past (2005 until the future (2020. Results In 2005 the ICER was €1,9 million/quality-adjusted-life-year (QALY, meaning that the 70-gene signature was not yet cost-effective compared to the current clinical guideline. The ICER for the 70-gene signature improved over time with a range of €1,9 million to €26,145 in 2010 and €1,9 million to €11,123/QALY in 2020 depending on the separate scenario used. From 2010, the 70-gene signature should be cost-effective, based on the combined scenario. The uptake-scenario had strongest influence on the cost-effectiveness. Conclusions When optimal diffusion of a technology is sought, incorporating process

  2. Development of Seismic Safety Assessment Technology for Containment Structure

    Energy Technology Data Exchange (ETDEWEB)

    Jang, J.B.; Suh, Y.P.; Lee, J.R. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This final report is made based on the research results of seismic analysis and seismic margin assessment field, carried out during 3rd stage ('01.4.1{approx}'02.3.31) under financial support of MOST(Ministry of Science and Technology). The objective of this research is to develop the soil - structure interaction analysis technique with high reliability, the main research subjects, performed during 3rd stage are as follows. 1) Preparation of user's guide manual for SSI analysis with high accuracy. 2) Sensitivity analysis of effective shear strain and seismic input motion. 3) Database construction of Hualien earthquake recorded data. (author). 21 refs., 27 figs., 2 tabs.

  3. TECHNOLOGY ASSESSMENT OF TIRE MOULD CLEANING SYSTEMS AND QUALITY FINISHING

    Directory of Open Access Journals (Sweden)

    Cristiano Fragassa

    2016-09-01

    Full Text Available A modern tire merges up to 300 different chemical elements, both organic and inorganic, natural and synthetic. During manufacturing, various processes are present such as mixing, calendering and extrusion, forming dozens of individual parts. Then, moulding and vulcanization inside special moulds provides the tire its final shape. Since the surface quality of moulds strongly affects the quality of tire, mould cleaning is a fundamental aspect of the whole tire production and cleaning techniques are in continuous development. This investigation proposes a global technology assessment of tire mould cleaning systems including uncommon solutions as multi-axis robots for cleaning on board by laser or dry ice, or ultrasonic cleaning which use cavitation. A specific attention is also focused on the industry adoption of spring-vents in moulds and how they are influencing the development the quality of final products.

  4. Development of Seismic Safety Assessment Technology for Containment Structure

    Energy Technology Data Exchange (ETDEWEB)

    Jang, J.B.; Suh, Y.P.; Lee, J.R. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This final report is made based on the research results of seismic analysis and seismic margin assessment field, carried out during 3rd stage ('01.4.1{approx}'02.3.31) under financial support of MOST(Ministry of Science and Technology). The objective of this research is to develop the soil - structure interaction analysis technique with high reliability, the main research subjects, performed during 3rd stage are as follows. 1) Preparation of user's guide manual for SSI analysis with high accuracy. 2) Sensitivity analysis of effective shear strain and seismic input motion. 3) Database construction of Hualien earthquake recorded data. (author). 21 refs., 27 figs., 2 tabs.

  5. ECASTAR: Energy conservation. An assessment of systems, technologies and requirements

    Science.gov (United States)

    1975-01-01

    A methodology was presented for a systems approach to energy conservation actions and their potentials and impacts in the United States. Constraints affecting the approach were ranked, and the most important ones are the present economic and technical conditions. The following unresolved issues were identified: consumptive lifestyles vs. conservation ethic, environmental standards vs. energy conservation, capital availability, decentralization and vertical integration vs. centralization, fuel rich regions vs. fuel poor regions, supply vs. end use conservation, life cycle costing vs. initial cost, mandatory savings vs. voluntary savings, labor intensive vs. capital intensive, price control vs. free market. The following recommendations were made: provide action/impact assessment, establish regional energy centers, improve technology articulation with government, design total energy systems, utilize existing systems approach expertise.

  6. Multipurpose Panel Display Device Investigation. [technology assessment and product development

    Science.gov (United States)

    Sliwa, R.

    1977-01-01

    A multipurpose panel was developed to provide a flexible control and a LED display panel with easily changeable nomenclature for use in applications where panel space is limited, but where a number of similar subsystems must be controlled, or where basic panel nomenclature and functions must be changed rapidly, as in the case of between mission changes of space shuttle payloads. In the first application, panel area limitations are overcome by time sharing a central control panel among several subsystems. In the latter case, entire control panel changes are effected by simply replacing a memory module, thereby reducing the extent of installation and checkout procedures between missions. Several types of control technologies (other than LED's) which show potential in meeting criteria for overcoming limitations of the panel are assessed.

  7. Environmental assessment for the Processing and Environmental Technology Laboratory (PETL)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The U.S. Department of Energy (DOE) has prepared an environmental assessment (EA) on the proposed Processing and Environmental Technology Laboratory (PETC) at Sandia National Laboratories/New Mexico (SNL/NM). This facility is needed to integrate, consolidate, and enhance the materials science and materials process research and development (R&D) currently in progress at SNL/NM. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, an environmental impact statement is not required, and DOE is issuing this Finding of No Significant Impact (FONSI).

  8. Health technology assessment implementation: the politics of ethics.

    Science.gov (United States)

    Callahan, Daniel

    2012-01-01

    Using a 2009 American debate on a federal public health recommendation on mammography screening for women under the age of 50 as a case study, it is argued that public acceptance of health technology assessment (HTA) depends on the ethical acceptability of its recommendations. At the same time, that acceptability cannot be separated from the politics and values of the health care system of which it is part. In the United States, those values display a sharp ideological split between a conservative individual-based ethic and a liberal community-oriented ethic. A clash of this kind cannot be solved by invocation of ethical principles when it is those principles themselves that are in conflict. Inevitably HTA acceptance is threatened by this conflict as is the fate of health care reform.

  9. Indexes system of technological condition assessment of economic branches

    Science.gov (United States)

    Chuvashova, M. N.; Avramchikova, N. T.; Antamoshkin, A. N.

    2015-10-01

    The increased level of innovative production process, connected with the current trends, points out the necessity of economic diversification of the whole national economy as well as regional economies in order to increase competitiveness and stable development. Russian regional economies are characterized with local directive of development and innovative processes have evident local vector. Intensive development of Siberian regional economies, which depends on oil and mining industries, considerably falls behind the world indicators according to the GRP output per head. To improve the quality of economic space the authors have suggested a new scientific approach, which allows qualitative assessment inside the economic space of resource-based regions, based on principles of high technological modes development inside economic branches taking into account density, regular enterprise distribution and connectivity of commercial organizations as well as secures innovative development of regional economy and its competitiveness. In this context it is necessary to develop a modern system of indexes, characterizing the structure of economic branches in accordance with present technological modes and at the same time the dynamics of appropriate structural shifts in regional economies of this type.

  10. Japanese technology assessment: Computer science, opto- and microelectronics mechatronics, biotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Brandin, D.; Wieder, H.; Spicer, W.; Nevins, J.; Oxender, D.

    1986-01-01

    The series studies Japanese research and development in four high-technology areas - computer science, opto and microelectronics, mechatronics (a term created by the Japanese to describe the union of mechanical and electronic engineering to produce the next generation of machines, robots, and the like), and biotechnology. The evaluations were conducted by panels of U.S. scientists - chosen from academia, government, and industry - actively involved in research in areas of expertise. The studies were prepared for the purpose of aiding the U.S. response to Japan's technological challenge. The main focus of the assessments is on the current status and long-term direction and emphasis of Japanese research and development. Other aspects covered include evolution of the state of the art; identification of Japanese researchers, R and D organizations, and resources; and comparative U.S. efforts. The general time frame of the studies corresponds to future industrial applications and potential commercial impacts spanning approximately the next two decades.

  11. Flightdeck Automation Problems (FLAP) Model for Safety Technology Portfolio Assessment

    Science.gov (United States)

    Ancel, Ersin; Shih, Ann T.

    2014-01-01

    NASA's Aviation Safety Program (AvSP) develops and advances methodologies and technologies to improve air transportation safety. The Safety Analysis and Integration Team (SAIT) conducts a safety technology portfolio assessment (PA) to analyze the program content, to examine the benefits and risks of products with respect to program goals, and to support programmatic decision making. The PA process includes systematic identification of current and future safety risks as well as tracking several quantitative and qualitative metrics to ensure the program goals are addressing prominent safety risks accurately and effectively. One of the metrics within the PA process involves using quantitative aviation safety models to gauge the impact of the safety products. This paper demonstrates the role of aviation safety modeling by providing model outputs and evaluating a sample of portfolio elements using the Flightdeck Automation Problems (FLAP) model. The model enables not only ranking of the quantitative relative risk reduction impact of all portfolio elements, but also highlighting the areas with high potential impact via sensitivity and gap analyses in support of the program office. Although the model outputs are preliminary and products are notional, the process shown in this paper is essential to a comprehensive PA of NASA's safety products in the current program and future programs/projects.

  12. Life cycle impact assessment of various waste conversion technologies.

    Science.gov (United States)

    Khoo, Hsien H

    2009-06-01

    Advanced thermal treatment technologies utilizing pyrolysis or gasification, as well as a combined approach, are introduced as sustainable methods to treat wastes in Singapore. Eight different technologies are evaluated: pyrolysis-gasification of MSW; pyrolysis of MSW; thermal cracking gasification of granulated MSW; combined pyrolysis, gasification and oxidation of MSW; steam gasification of wood; circulating fluidized bed (CFB) gasification of organic wastes; gasification of RDF; and the gasification of tyres. Life cycle assessment is carried out to determine the environmental impacts of the various waste conversion systems including global warming potential, acidification potential, terrestrial eutrophication and ozone photochemical formation. The normalization and weighting results, calculated according to Singapore national emission inventories, showed that the two highest impacts are from thermal cracking gasification of granulated MSW and the gasification of RDF; and the least are from the steam gasification of wood and the pyrolysis-gasification of MSW. A simplified life cycle cost comparison showed that the two most costs-effective waste conversion systems are the CFB gasification of organic waste and the combined pyrolysis, gasification and oxidation of MSW. The least favorable - highest environmental impact as well as highest costs - are the thermal cracking gasification of granulated MSW and the gasification of tyres.

  13. Enhancing Teachers' Technological Knowledge and Assessment Practices to Enhance Student Learning in Technology: A Two-year Classroom Study

    Science.gov (United States)

    Moreland, Judy; Jones, Alister; Northover, Ann

    2001-02-01

    This paper reports on a two-year classroom investigation of primary school (Years 1-8) technology education. The first year of the project explored emerging classroom practices in technology. In the second year intervention strategies were developed to enhance teaching, learning and assessment practices. Findings from the first year revealed that assessment was often seen in terms of social and managerial aspects, such as teamwork, turn taking and co-operative skills, rather than procedural and conceptual technological aspects. Existing formative interactions with students distorted the learning away from the procedural and conceptual aspects of the subject. The second year explored the development of teachers' technological knowledge in order to enhance formative assessment practices in technology, to inform classroom practice in technology, and to enhance student learning. Intervention strategies were designed to enhance the development of procedural, conceptual, societal and technical aspects of technology for teachers and students. The results from this intervention were very positive. This paper highlights the importance of developing teacher expertise pertaining to broad concepts of technology, detailed concepts in different technological areas and general pedagogical knowledge. The findings from this research therefore have implications for thinking about teaching, learning and assessment in technology.

  14. Health Technology Assessment and vaccine: new needs and opportunities?

    Directory of Open Access Journals (Sweden)

    Giuseppe La Torre

    2007-03-01

    Full Text Available Health Technology Assessment (HTA can represent an innovative and effective approach to supply decisionmakers with a valid instrument to improve the allocation of resources in the field of vaccines. We proposed a HTA approach for considering the introduction of a new vaccine that could potentially have a great impact on the population’s health, using as an example the vaccine against Human Papilloma Virus (HPV. This approach could be of great interest when the decision making process involves choices regarding new vaccines. We developed a HTA approach for assessing all of the aspects involved in the introduction of vaccines against HPV in Italy, considering the following issues: - epidemiological evaluation of HPV infection and related pathologies through the consultation of data banks and the scientific literature; - evaluation of health care resources utilisation by people suffering from the infection/ related diseases, through the consultation of hospital archives; - systematic review and meta-analysis of randomised clinical trials on HPV vaccination effectiveness and safety; - mathematical modelling and economic evaluation of the vaccination using a cost-effectiveness analysis; - evaluation of the impact of vaccination on the Health System [organisational aspects, vaccine surveillance, relationship between different decisional levels (national, regional]; - analysis of the ethical, social (acceptability, availability, accessibility, information and legislative aspects of vaccination. A HTA report on the new vaccine could represent an new important tool to support the choice of decision makers in order to better inform the allocation of economic resources and maximize healthcare services, since it takes into account not only the burden and the epidemiology of the disease, and the economic evaluation of different scenarios, but also the social, legal and bioethical aspects. For HTA to support the introduction of new technologies, and new

  15. Comparative evaluation by lifecycle and risk assessment of agrobiological and technological routes of production

    NARCIS (Netherlands)

    Moll, H.C.; Schoot Uiterkamp, A.J.M.

    1997-01-01

    The application of lifecycle and risk assessment methodologies for environmental assessment of agricultural products is growing and produces interesting results. This allows comparisons between agricultural and technological routes of production. An evaluation of such assessments provides increased

  16. A prototype catalogue: DOE National Laboratory technologies for infrastructure modernization. Letter report made publicly available December 1992

    Energy Technology Data Exchange (ETDEWEB)

    Currie, J.W.; Wilfert, G.L.; March, F.

    1990-01-01

    The purpose of this report is to provide the Office of Technology Assessment (OTA) with information about selected technologies under development in the Department of Energy (DOE) through its National Laboratory System and its Program Office operations. The technologies selected are those that have the potential to improve the performance of the nation`s public works infrastructure. The product is a relational database that we refer to as a ``prototype catalogue of technologies.`` The catalogue contains over 100 entries of DOE-supported technologies having potential application to infrastructure-related problems. The work involved conceptualizing an approach, developing a framework for organizing technology information, and collecting samples of readily available data to be put into a prototype catalogue. In developing the catalogue, our objectives were to demonstrate the concept and provide readily available information to OTA. As such, the catalogue represents a preliminary product. The existing database is not exhaustive and likely represents only a fraction of relevant technologies developed by DOE. In addition, the taxonomy we used to classify technologies is based on the judgment of project staff and has received minimal review by individuals who have been involved in the development and testing of the technologies. Finally, end users will likely identify framework changes and additions that will strengthen the catalogue approach. The framework for the catalogue includes four components: a description of the technology, along with potential uses and other pertinent information; identification of the source of the descriptive information; identification of a person or group knowledgeable about the technology; and a classification of the described technology in terms of its type, application, life-cycle use, function, and readiness.

  17. Biogas upgrading technologies:Energetic analysis and environmental impact assessment

    Institute of Scientific and Technical Information of China (English)

    Yajing Xu; Ying Huang; Bin Wu; Xiangping Zhang; Suojiang Zhang

    2015-01-01

    Biogas upgrading for removing CO2 and other trace components from raw biogas is a necessary step before the biogas to be used as a vehicle fuel or supplied to the natural gas grid. In this work, three technologies for biogas upgrading, i.e., pressured water scrubbing (PWS), monoethanolamine aqueous scrubbing (MAS) and ionic liquid scrubbing (ILS), are studied and assessed in terms of their energy consumption and environmental impacts with the process simulation and green degree method. A non-random-two-liquid and Henry's law property method for a CO2 separation system with ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([bmim][Tf2N]) is established and verified with experimental data. The assessment results indicate that the specific energy consumption of ILS and PWS is almost the same and much less than that of MAS. High purity CO2 product can be obtained by MAS and ILS methods, whereas no pure CO2 is recovered with the PWS. For the environmental aspect, ILS has the highest green degree production value, while MAS and PWS produce serious environmental impacts.

  18. Integrating ethics in health technology assessment: many ways to Rome.

    Science.gov (United States)

    Hofmann, Björn; Oortwijn, Wija; Bakke Lysdahl, Kristin; Refolo, Pietro; Sacchini, Dario; van der Wilt, Gert Jan; Gerhardus, Ansgar

    2015-01-01

    The aim of this study was to identify and discuss appropriate approaches to integrate ethical inquiry in health technology assessment (HTA). The key question is how ethics can be integrated in HTA. This is addressed in two steps: by investigating what it means to integrate ethics in HTA, and by assessing how suitable the various methods in ethics are to be integrated in HTA according to these meanings of integration. In the first step, we found that integrating ethics can mean that ethics is (a) subsumed under or (b) combined with other parts of the HTA process; that it can be (c) coordinated with other parts; or that (d) ethics actively interacts and changes other parts of the HTA process. For the second step, we found that the various methods in ethics have different merits with respect to the four conceptions of integration in HTA. Traditional approaches in moral philosophy tend to be most suited to be subsumed or combined, while processual approaches being close to the HTA or implementation process appear to be most suited to coordinated and interactive types of integration. The article provides a guide for choosing the ethics approach that appears most appropriate for the goals and process of a particular HTA.

  19. Assessing the Role of Technology Adoption in China's Growth Performance

    DEFF Research Database (Denmark)

    Wirz, Nadja

    to what extent these productivity increases can be explained by technology-adoption theory. In less developed countries, the key element behind technological progress is technology adoption, the process of copying technological knowledge invented throughout the world. To uncover a measure of China...

  20. Developing an Instrument for Assessing Students' Concepts of the Nature of Technology

    Science.gov (United States)

    Liou, Pey-Yan

    2015-01-01

    Background: The nature of technology has been rarely discussed despite the fact that technology plays an essential role in modern society. It is important to discuss students' concepts of the nature of technology, and further to advance their technological literacy and adaptation to modern society. There is a need to assess high school students'…

  1. Technology assessment in Australia : the case for a formal agency to improve advice to policy makers

    NARCIS (Netherlands)

    Russell, A. Wendy; Vanclay, Frank M.; Salisbury, Janet G.; Aslin, Heather J.

    The pace and reach of technological change has led to calls for better technology policy and governance to improve social outcomes. Technology assessment can provide information and processes to improve technology policy. Having conducted a review of international best practice, we established a set

  2. Electronically tunable voltage-mode universal filter with single-input five-output using simple OTAs

    Science.gov (United States)

    Kumngern, Montree; Suwanjan, Peerawut; Dejhan, Kobchai

    2013-08-01

    This article presents a new electronically tunable voltage-mode universal biquadratic filter with single-input five-output using simple operational transconductance amplifiers (OTAs) and grounded capacitors. The proposed configuration provides low-pass, band-pass, high-pass, band-stop and all-pass voltage responses at a high-impedance input terminal that enables easy cascading in voltage-mode. The natural frequency and the quality factor can be set orthogonally by adjusting the circuit components. The natural frequency can also be controlled electronically by adjusting the bias currents of the OTAs. For realising all the five standard filtering functions, no critical-matching conditions are imposed and all the incremental parameter sensitivities are low. Experimental and simulation results that confirm the theoretical predictions are given.

  3. Psychometric evaluation of a new assessment of the ability to manage technology in everyday life.

    Science.gov (United States)

    Malinowsky, Camilla; Nygård, Louise; Kottorp, Anders

    2011-03-01

    Technology increasingly influences the everyday lives of most people, and the ability to manage technology can be seen as a prerequisite for participation in everyday occupations. However, knowledge of the ability and skills required for management of technology is sparse. This study aimed to validate a new observation-based assessment, the Management of Everyday Technology Assessment (META). The META has been developed to assess the ability to manage technology in everyday life. A sample of 116 older adults with and without cognitive impairment were observed and interviewed by the use of the META when managing their everyday technology at home. The results indicate that the META demonstrates acceptable person response validity and technology goodness-of-fit. Additionally, the META can separate individuals with higher ability from individuals with lower ability to manage everyday technology. The META can be seen as a complement to existing ADL assessment techniques and is planned to be used in both research and practice.

  4. 78 FR 49287 - Environmental Assessment for Potential Lease Issuance and Marine Hydrokinetic Technology Testing...

    Science.gov (United States)

    2013-08-13

    ... well as identification of important environmental issues associated with data collection and technology... Bureau of Ocean Energy Management Environmental Assessment for Potential Lease Issuance and Marine Hydrokinetic Technology Testing Offshore Florida AGENCY: Bureau of Ocean Energy Management (BOEM),...

  5. Assessment of Gari Processing Technologies in Oja-Iya Area of ...

    African Journals Online (AJOL)

    Assessment of Gari Processing Technologies in Oja-Iya Area of Ilorin Metropolis. ... Journal of Agricultural Research and Development ... Large scale gari processing was largely unsuccessful in the area because of lack of modern technology, ...

  6. Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification.

    Science.gov (United States)

    Mukhopadhyay, Amiya Kumar

    2013-07-01

    Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino's classification to incorporate the nevus of Ito into the classification for the Ota's nevus may be appropriate.

  7. Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification

    Science.gov (United States)

    Mukhopadhyay, Amiya Kumar

    2013-01-01

    Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino's classification to incorporate the nevus of Ito into the classification for the Ota's nevus may be appropriate. PMID:23918999

  8. Why Portfolio Assessment is Introduced to Inner Mongolia University of Science and Technology

    Institute of Scientific and Technical Information of China (English)

    潘若芸

    2004-01-01

    The concept of portfolio assessment derived from the field of fine arts. It has been proven an effective learning and assessment tool. In Inner Mongolia University of Science and Technology, the traditional assessment is still used. After analysing the benefits and disadvantages, the author is eager to introduce it to Inner Mongolia University of Science and Technology. The problems are also predicted.

  9. 1st International Ocean Technology Congress on EEZ Resources : Technology Assessment

    CERN Document Server

    Champ, Michael

    1990-01-01

    Today western nations consume annually only a small percentage of their resources from the sea, despite the proclamation of Exclusive Economic Zones (EEZ) by many. In contrast, most Pacific Basin Countries obtain more than a quarter of their annual needs from the ocean. Determination of greater rewards from the development of marine resources is markedly inhibited by the limited technical abilities available to locate and assess them. Knowledge of Exclusive Economic Zone resources is schematic and generalised, and a detailed understanding of the geology and processes relating to the economic use of the seafloor is both fragmentary and very basic. Technology for mapping the mineral resources of continental shelves and ocean areas, except in active offshore hydrocarbon provinces, has been largely developed in pursuit of scientific objectives and competence to rapidly appraise economic potential is limited. Similarly, the capability to characterise and evaluate the other resources of the seas is rudimentary. The...

  10. Quadrennial Technology Review 2015: Technology Assessments--Marine and Hydrokinetic Power

    Energy Technology Data Exchange (ETDEWEB)

    Sam Baldwin, Gilbert Bindewald, Austin Brown, Charles Chen, Kerry Cheung, Corrie Clark, Joe Cresko,

    2015-10-07

    Marine and hydrokinetic (MHK) technologies convert the energy of waves, tides, and river and ocean currents into electricity. With more than 50% of the U.S. population living within 50 miles of the nation’s coasts, MHK technologies hold significant potential to supply renewable electricity to consumers in coastal load centers, particularly in the near term in areas with high costs of electricity and longer term in high resource areas in close proximity to major coastal load centers. MHK resource assessments identify a total U.S. technical resource potential of approximately 1250–1850 terawatt-hours (TWh) of generation per year from ocean wave, ocean current, ocean tidal, and river current energy. Of this, the U.S. continental technical resource potential is approximately 500–750 TWh/year. For context, roughly 90,000 homes can be powered by 1 TWh of electricity generation each year. A cost-effective MHK industry could provide a substantial amount of electricity for the nation owing in large part to its unique advantages as a source of energy, including its vast resource potential, its close proximity to major coastal load centers, and its long-term predictability and near-term forecastability.

  11. Methods for assessment of innovative medical technologies during early stages of development.

    OpenAIRE

    Hagen, Anja; Schönermark, Matthias P.; Lühmann, Dagmar; Neumann, Ulrike; Bartelmes, Marc

    2009-01-01

    Conventional Health Technology Assessment (HTA) is usually conducted at a point in time at which the development of the respective technology may no longer be influenced. By this time developers and/or purchasers may have misinvested resources. Thus the demand for Technology Assessment (TA) which incorporates appropriate methods during early development stages of a technology becomes apparent. Against this health political background, the present report describes methods for a development-acc...

  12. Large Artery Stiffness Assessment Using SphygmoCor Technology

    Science.gov (United States)

    Butlin, Mark; Qasem, Ahmad

    2017-01-01

    Large artery stiffness assessment has been an integral part of the SphygmoCor technology since 1998. Aortic stiffness is approximated with non-invasive measurement of carotid-femoral pulse wave velocity, with improvements made with time to make the assessment procedure quicker and more user independent. Also standard in the devices is the ability to reliably calculate the central aortic waveform shape from a peripheral pressure waveform from either the brachial or radial artery. This waveform contains much information beyond peak and trough (systolic and diastolic pressure). Relative waveform features such as the augmentation index, wave reflection magnitude, reflection time index, and subendocardial viability ratio are parameters that are influenced by the stiffness of systemic arteries. This article briefly describes these parameters related to large artery stiffness and provides reference to validation and repeatability studies relative to the clinical use of the SphygmoCor devices. It is beyond the scope to review here the 424 original research articles that have employed SphygmoCor devices in measuring arterial stiffness. Instead, the method of measurement across the devices is described, including tonometry, volumetric displacement through cuff placement around limbs, and ambulatory monitoring. Key population and subpopulation studies are cited where the average stiffness parameter progression with age and gender, as measured by SphygmoCor devices, is quantified in the healthy and general population. Finally, with reference to guidelines from working groups on arterial stiffness and hypertension, the clinical utility of large artery stiffness measurement is discussed in the context of the arterial stiffness parameters provided by the SphygmoCor systems. PMID:28229053

  13. Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.

    Science.gov (United States)

    Trufant, Joshua W; Brenn, Thomas; Fletcher, Christopher D M; Virata, Andrew R; Cook, Deborah L; Bosenberg, Marcus W

    2009-12-01

    Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features. The psammomatous variety is associated with Carney complex, a multiple neoplasia syndrome with spotty skin pigmentation. We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis. Case 1 involves a 40-year-old woman with a 1.8-cm, deeply pigmented, trigeminal nerve mass and pigmentation of the maxillary sinus mucosa and bone. Case 2 involves a 53-year-old woman with a 1.5-cm mass adjacent to the clavicle. Microscopically, both masses consist of partially encapsulated epithelioid and spindle cells with abundant melanin pigment, arising in association with peripheral nerves. Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma. No psammoma bodies are noted, and neither patient exhibits any additional features of Carney complex. Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases. Distinguishing this nerve sheath tumor from malignant melanoma can be difficult but is of great clinical importance due to differences in prognosis and treatment.

  14. An Empirical Assessment of Science Teachers' Intentions toward Technology Integration

    Science.gov (United States)

    Wu, Weishen; Chang, Huey-Por; Guo, Chorng-Jee

    2008-01-01

    Building upon three theoretical paradigms (technology acceptance model, social cognitive theory, and task-technology fit), the present study aims to investigate the relationship among intrinsic and extrinsic factors influencing science teachers' intentions toward teaching with information technology (IT). A sample of 226 middle school science…

  15. Assessing Pre-Service Teachers' Information and Communication Technologies Knowledge

    Science.gov (United States)

    Kovalik, Cindy; Kuo, Chia-Ling; Karpinski, Aryn

    2013-01-01

    The impact of a redesigned educational technology course on preservice teachers' knowledge and skills with regard to information and communications technology as defined by ISTE's National Educational Technology Standards for Teachers (NETS-T) was investigated in this study. Two changes were made to the course: (1) a commercially available…

  16. Assessing Pre-Service Teachers' Information and Communication Technologies Knowledge

    Science.gov (United States)

    Kovalik, Cindy; Kuo, Chia-Ling; Karpinski, Aryn

    2013-01-01

    The impact of a redesigned educational technology course on preservice teachers' knowledge and skills with regard to information and communications technology as defined by ISTE's National Educational Technology Standards for Teachers (NETS-T) was investigated in this study. Two changes were made to the course: (1) a commercially available…

  17. 1:1 Technology and Computerized State Assessments

    Science.gov (United States)

    Medlin, Shane A.

    2016-01-01

    American students in the 21st century are growing up with Internet accessible technology available at their fingertips. Considering this and the continued pressure to compete in a global society, The United States' Department of Education's National Education Technology Plan (NETP) (2010) calls for educators to leverage technology in order to…

  18. [The Health Technology Assessment Engine of the Academic Hospital of Udine: first appraisal].

    Science.gov (United States)

    Vidale, Claudia

    2014-01-01

    The Health Technology Assessment Engine (HTAE) of the Academic Hospital of Udine aggregates about one hundred of health technology assessment websites. It was born thanks to Google technology in 2008 and after about four years of testing it became public for everybody from the Homepage of the Italian Society of Health Technology Assessment (SIHTA). In this paper the first results obtained with this resource are reported. The role of the scientific librarian is examined not only as a support specialist in bibliographic search but also as a creative expert in managing new technologies for the community.

  19. [Health research and health technology assessment in Chile].

    Science.gov (United States)

    Espinoza, Manuel Antonio; Cabieses, Báltica; Paraje, Guillermo

    2014-01-01

    Health research is considered an essential element for the improvement of population health and it has been recommended that a share of the national health budget should be allocated to develop this field. Chile has undertaken efforts in the last decades in order to improve the governmental structure created to promote the development of health research, which has increased human resources and funding opportunities. On the other hand, the sustained economic growth of Chile in the last decades suggests that the health expenditure will maintain its increasing trend in the following years. This additional funding could be used to improve coverage of current activities performed in the health system, but also to address the incorporation of new strategies. More recently, health technology assessment (HTA) has been proposed as a process to support decisions about allocation of resources based on scientific evidence. This paper examines the relationship between the development of health research and the HTA process. First, it presents a brief diagnosis of the situation of health research in Chile. Second, it reviews the conceptual basis and the methods that account for the relationship between a HTA process and the development of health research. In particular, it emphasizes the relevance of identifying information gaps where funding additional research can be considered a good use of public resources. Finally, it discusses the challenges and possible courses of action that Chile could take in order to guarantee the continuous improvement of an articulated structure for health research and HTA.

  20. [Citizen participation in the context of health technology assessment].

    Science.gov (United States)

    Freile-Gutiérrez, Berenice

    2014-01-01

    Citizen participation is important in all economic sectors of the democratic world, as it is also in the field of health. This is due to the significant value of life and therefore enjoying this in a healthy condition. This paper seeks to provide an overview of public participation in the context of Health Technology Assessments (HTA), covering from conceptualization to practical experiences. Within the existing literature, the definitions and methodological aspects of the topic discussed are reviewed, as well as how citizen participation in HTA agencies is manifested, presenting barriers as well as enablers for public involvement. In the Chilean case, where there are no public participation experiences in the context of HTA, a review of these initiatives in the health care sector is performed. In light with the studies examined, it is concluded that there is much to advance in the concreteness of citizen participation in HTA's agencies; efforts at institutional level as well as from community organizations are needed. This review can be useful as an antecedent for countries that are considering incorporating HTA in the future.

  1. Interview: Health technology assessment in Asia: an emerging trend.

    Science.gov (United States)

    Yang, Bong-min

    2012-05-01

    Bong-min Yang, PhD (in economics), is Professor and former Dean of the School of Public Health at the Seoul National University, South Korea. Professor Yang has led research and written many papers in health economics and healthcare systems in Korea and Asia. His recent research and publications focus on the field of economic evaluation and outcomes research. He played a key role in the introduction of a formal health technology assessment system within Korean healthcare. He is currently serving as Executive Director, Institute of Health and Environment, Seoul National University. In addition to his research and publications, Professor Yang is Associate Editor for Journal of Comparative Effectiveness Research, is co-editor-in-chief for Value in Health Regional Issues, and is currently chair of the Management Advisory Board of Value in Health and a member of the editorial board of the Journal of Medical Economics. He has been a policy consultant to China, Japan, Indonesia, Hong Kong, Malaysia, Taiwan, Thailand and India. He has also worked as a short-term consultant at the WHO, ADB, UNDP and the World Bank. For the Korean government, he served as Chairperson of the Health Insurance Reform Committee, and Chairperson of the Drug Pricing and Reimbursement Committee. He is currently serving as Chair of the International Society of Pharmacoeconomics and Outcomes Research-Asia Consortium, and a member of the Board of Directors of the International Society of Pharmacoeconomics and Outcomes Research.

  2. Subgroup analyses of clinical effectiveness to support health technology assessments.

    Science.gov (United States)

    Paget, Marie-Ange; Chuang-Stein, Christy; Fletcher, Christine; Reid, Carol

    2011-01-01

    Subgroup analysis is an integral part of access and reimbursement dossiers, in particular health technology assessment (HTA), and their HTA recommendations are often limited to subpopulations. HTA recommendations for subpopulations are not always clear and without controversies. In this paper, we review several HTA guidelines regarding subgroup analyses. We describe good statistical principles for subgroup analyses of clinical effectiveness to support HTAs and include case examples where HTA recommendations were given to subpopulations only. Unlike regulatory submissions, pharmaceutical statisticians in most companies have had limited involvement in the planning, design and preparation of HTA/payers submissions. We hope to change this by highlighting how pharmaceutical statisticians should contribute to payers' submissions. This includes early engagement in reimbursement strategy discussions to influence the design, analysis and interpretation of phase III randomized clinical trials as well as meta-analyses/network meta-analyses. The focus on this paper is on subgroup analyses relating to clinical effectiveness as we believe this is the first key step of statistical involvement and influence in the preparation of HTA and reimbursement submissions.

  3. Reimbursement of pharmaceuticals: reference pricing versus health technology assessment.

    Science.gov (United States)

    Drummond, Michael; Jönsson, Bengt; Rutten, Frans; Stargardt, Tom

    2011-06-01

    Reference pricing and health technology assessment are policies commonly applied in order to obtain more value for money from pharmaceuticals. This study focussed on decisions about the initial price and reimbursement status of innovative drugs and discussed the consequences for market access and cost. Four countries were studied: Germany, The Netherlands, Sweden and the United Kingdom. These countries have operated one, or both, of the two policies at certain points in time, sometimes in parallel. Drugs in four groups were considered: cholesterol-lowering agents, insulin analogues, biologic drugs for rheumatoid arthritis and "atypical" drugs for schizophrenia. Compared with HTA, reference pricing is a relatively blunt instrument for obtaining value for money from pharmaceuticals. Thus, its role in making reimbursement decisions should be limited to drugs which are therapeutically equivalent. HTA is a superior strategy for obtaining value for money because it addresses not only price but also the appropriate indications for the use of the drug and the relation between additional value and additional costs. However, given the relatively higher costs of conducting HTAs, the most efficient approach might be a combination of both policies.

  4. Use of wearable technology for performance assessment: a validation study.

    Science.gov (United States)

    Papi, Enrica; Osei-Kuffour, Denise; Chen, Yen-Ming A; McGregor, Alison H

    2015-07-01

    The prevalence of osteoarthritis is increasing globally but current compliance with rehabilitation remains poor. This study explores whether wearable sensors can be used to provide objective measures of performance with a view to using them as motivators to aid compliance to osteoarthritis rehabilitation. More specifically, the use of a novel attachable wearable sensor integrated into clothing and inertial measurement units located in two different positions, at the waist and thigh pocket, was investigated. Fourteen healthy volunteers were asked to complete exercises adapted from a knee osteoarthritis rehabilitation programme whilst wearing the three sensors including five times sit-to-stand test, treadmill walking at slow, preferred and fast speeds. The performances of the three sensors were validated against a motion capture system and an instrumented treadmill. The systems showed a high correlation (r(2) > 0.7) and agreement (mean difference range: -0.02-0.03 m, 0.005-0.68 s) with gold standards. The novel attachable wearable sensor was able to monitor exercise tasks as well as the inertial measurement units (ICC > 0.95). Results also suggested that a functional placement (e.g., situated in a pocket) is a valid position for performance monitoring. This study shows the potential use of wearable technologies for assessing subject performance during exercise and suggests functional solutions to enhance acceptance.

  5. Assessment of conducting polymer applications in power equipment technology

    Energy Technology Data Exchange (ETDEWEB)

    Schoch, K.F. Jr.; Bennett, A.I.; Burghardt, R.R.; Cookson, A.H.; Kennedy, W.N.; Oommen, T.V.; Saunders, H.E.; Smith, J.D.B.; Voshall, R.E. (Westinghouse Electric Corp., Pittsburgh, PA (USA)); Fort, E.M. (Westinghouse Electric Corp., Orlando, FL (USA)); Robbins, B. (Reynolds Metals Co., Richmond, VA (USA))

    1991-05-01

    This report describes for the first time the state-of-the-art in conducting polymer technology specifically relating to electric power apparatus for transmission, distribution and generation. Thirty-two new applications in power equipment are proposed and assessed. The areas of the proposed applications include solid dielectric cable, oil-filled cable, capacitors, transformers, rotating machines, bushings, surge supressors, vacuum interrupters, gas-insulated equipment, and miscellaneous applications. The best applications will result in improved reliability and efficiency, design innovations, and simpler manufacturing procedures by taking advantage of the particular characteristics of conducting polymers. These characteristics include good control of conductivity over a range of 10{sup {minus}8} to 10{sup 3} S/cm, compatibility with organic compounds, simple preparation and development of anisotropic conductivity by polymer orientation. The proposed applications were evaluated according to technical impact, probability of success, economic impact, and time frame for implementation. The state-of-the-art of conducting polymers is also reviewed and areas requiring further research for these applications are discussed. Because of substantial recent progress is developing more practical conducting polymer materials, now is an excellent time to pursue the additional research needed. 37 refs., 16 figs., 15 tabs.

  6. Assessment of basic research needs for greenhouse gas control technologies

    Energy Technology Data Exchange (ETDEWEB)

    Benson, S.M.; Chandler, W.; Edmonds, J.; Houghton, J.; Levine, M.; Bates, L.; Chum, H.; Dooley, J.; Grether, D.; Logan, J.; Wiltsee, G.; Wright, L.

    1998-09-01

    This paper is an outgrowth of an effort undertaken by the Department of Energy's Office of Energy Research to assess the fundamental research needs to support a national program in carbon management. Five topics were identified as areas where carbon management strategies and technologies might be developed: (1) capture of carbon dioxide, decarbonization strategies, and carbon dioxide disposal and utilization; (2) hydrogen development and fuel cells; (3) enhancement of the natural carbon cycle; (4) biomass production and utilization; and (5) improvement of the efficiency of energy production, conversion, and utilization. Within each of these general areas, experts came together to identify targets of opportunity for fundamental research likely to lead to the development of mid- to long-term solutions for stabilizing or decreasing carbon dioxide and other greenhouse gases in the atmosphere. Basic research to support the options outlined above are far reaching-from understanding natural global processes such as the ocean and terrestrial carbon cycles to development of new materials and concepts for chemical separation. Examples of fundamental research needs are described in this paper.

  7. Evaluation of pressure sensing concepts: A technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, R.L.; Thacker, L.H.

    1993-09-01

    Advanced distributed control systems for electric power plants will require more accurate and reliable pressure gauges than those now installed. Future developments in power plant control systems are expected to use digital/optical networks rather than the analog/electric data transmission used in existing plants. Many pressure transmitters now installed use oil filling to separate process fluids from the gauge mechanism and are subject to insidious failures when the oil leaks. Testing and maintenance of pressure channels occupy a disproportionately large amount of effort to restore their accuracy and verify their operability. These and similar concerns have prompted an assessment of a broad spectrum of sensor technologies to aid in selecting the most likely candidates for adaptation to power plant applications. Ten representative conventional and thirty innovational pressure sensors are described and compared. Particular emphasis is focused on two categories: Silicon-integrated pressure sensors and fiber-optic sensors, and both of these categories are discussed in detail. Additional attractive concepts include variable reluctance gauges and resonant structure gauges that may not require oil buffering from the process fluid.

  8. Technology assessment in Non-PTA countries: an overview of recent developments in Europe

    OpenAIRE

    Boavida, Nuno; António B. Moniz

    2015-01-01

    Paper based on the text to be published in Moniz, A.B. and Okuwada, K. (2016), Technology Assessment in Japan and Europe, Karlsruhe, KIT Scientific Publishing This work aims to describe the latest developments in European countries or regions that lack a structure to develop Parliamentary Technology Assessment activities (named non-PTA). They are countries or regions where parliamentary-oriented technology assessment activities have not yet resulted in a formal structure, but where these a...

  9. Technology and Economic Assessment of Innovative Field Drainage Technologies in Denmark

    DEFF Research Database (Denmark)

    Gachango, Florence Gathoni

    technologies, and their willingness and extent of trading-off the existing farm management nutrient reduction measures with constructed wetland technology, iii) the cost-effectiveness of surface flow constructed wetlands, and iv) the strategies of incorporating the filter technologies into policy measures....... Overall, the findings in this thesis indicate a potential for integration of the filter technologies into nutrient reduction measures....

  10. Assessment and evaluation of technologies for environmental restoration. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Uzochukwu, G.A.

    1999-01-15

    Nuclear and commercial non-nuclear technologies that have the potential of meeting the environmental restoration objectives of the Department of Energy are being evaluated. A detailed comparison of innovative technologies available will be performed to determine the safest and most economical technology for meeting these objectives. Information derived from this effort will be matched with the multi-objective of the environmental restoration effort to ensure that the best, most economical, and the safest technologies are used in decision making at USDOE-SRS. Technology-related variables will be developed and the resulting data formatted and computerized for multimedia systems. The multimedia system will be made available to technology developers and evaluators to ensure that the safest and most economical technologies are developed for use at SRS and other DOE sites.

  11. Assessment and evaluation of technologies for environmental restoration. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Uzochukwu, G. A. [North Carolina A and T State Univ., Greensboro, NC (United States)

    2000-06-30

    Nuclear and commercial non-nuclear technologies that have the potential of meeting the environmental restoration objectives of the Department of Energy are being evaluated. A detailed comparison of innovative technologies available will be performed to determine the safest and most economical technology for meeting these objectives. Information derived from this effort will be matched with the multi-objective of the environmental restoration effort to ensure that the best, most economical, and the safest technologies are used in decision making at USDOE-SRS. Technology-related variables will be developed and the resulting data formatted and computerized for multimedia systems. The multimedia system will be made available to technology developers and evaluators to ensure that the safest and most economical technologies are developed for use at SRS and other DOE sites.

  12. Health technology assessment in the Balkans: opportunities for a balanced drug assessment system.

    Science.gov (United States)

    Dankó, Dávid; Petrova, Guenka

    2014-11-02

    Countries in the Balkan region use pharmaco-economic data for decisions about the inclusion of new pharmaceuticals into their positive drug lists, but no predefined frameworks are used and resources for health technology assessment (HTA) are limited. The goal of this analysis is to investigate into possible development directions for the HTA system in the region, and provide some practical recommendations for a sustainable model. For this purpose, the main factors currently influencing HTA in Balkan countries are briefly presented, and possible development strategies are compared. A resource-saving balanced assessment approach is proposed. It is aligned with available resources and capabilities, and helps access to new pharmaceuticals while ensuring the transparency of decision-making processes and the stability of the pharmaceutical budget.

  13. Maternal-Fetal Cancer Risk Assessment of Ochratoxin A during Pregnancy

    Directory of Open Access Journals (Sweden)

    Chit Shing Jackson Woo

    2016-03-01

    Full Text Available Increasing evidence has demonstrated that in utero exposure to environmental chemicals may interfere with fetal development and increase the risk of disease and cancer development later in life. Ochratoxin A (OTA has been proven to induce diverse toxic effects including teratogenicity, carcinogenicity, immunotoxicity and potential endocrine disruption. Due to the continuous and widespread occurrence of OTA as a potential contaminant of staple foods, there is increasing concern of in utero exposure of fetus to this mycotoxin. In this study, maternal-fetal risk assessment of OTA during pregnancy was conducted using the benchmark dose approach for genotoxic carcinogens. The daily intake of OTA for Egyptian pregnant women was estimated based on their serum OTA level using the refined Klaassen equation for pregnancy. Fetal exposure level was also estimated based on the maternal data. Comparison between the estimated daily exposure and the negligible cancer risk intake (NCRI, and the calculation of margin of exposure (MOE implicated that OTA exposure from dietary intake would be of low health concern for this general subpopulation of Egyptian women. This subpopulation of pregnant women was generally estimated not to be in high-risk for toxicity induced by OTA.

  14. Maternal-Fetal Cancer Risk Assessment of Ochratoxin A during Pregnancy.

    Science.gov (United States)

    Woo, Chit Shing Jackson; El-Nezami, Hani

    2016-03-23

    Increasing evidence has demonstrated that in utero exposure to environmental chemicals may interfere with fetal development and increase the risk of disease and cancer development later in life. Ochratoxin A (OTA) has been proven to induce diverse toxic effects including teratogenicity, carcinogenicity, immunotoxicity and potential endocrine disruption. Due to the continuous and widespread occurrence of OTA as a potential contaminant of staple foods, there is increasing concern of in utero exposure of fetus to this mycotoxin. In this study, maternal-fetal risk assessment of OTA during pregnancy was conducted using the benchmark dose approach for genotoxic carcinogens. The daily intake of OTA for Egyptian pregnant women was estimated based on their serum OTA level using the refined Klaassen equation for pregnancy. Fetal exposure level was also estimated based on the maternal data. Comparison between the estimated daily exposure and the negligible cancer risk intake (NCRI), and the calculation of margin of exposure (MOE) implicated that OTA exposure from dietary intake would be of low health concern for this general subpopulation of Egyptian women. This subpopulation of pregnant women was generally estimated not to be in high-risk for toxicity induced by OTA.

  15. Health risk assessment of ochratoxin A for all age-sex strata in a market economy.

    Science.gov (United States)

    Kuiper-Goodman, T; Hilts, C; Billiard, S M; Kiparissis, Y; Richard, I D K; Hayward, S

    2010-02-01

    In order to manage risk of ochratoxin A (OTA) in foods, we re-evaluated the tolerable daily intake (TDI), derived the negligible cancer risk intake (NCRI), and conducted a probabilistic risk assessment. A new approach was developed to derive 'usual' probabilistic exposure in the presence of highly variable occurrence data, such as encountered with low levels of OTA. Canadian occurrence data were used for various raw food commodities or finished foods and were combined with US Department of Agriculture (USDA) food consumption data, which included data on infants and young children. Both variability and uncertainty in input data were considered in the resulting exposure estimates for various age/sex strata. Most people were exposed to OTA on a daily basis. Mean adjusted exposures for all age-sex groups were generally below the NCRI of 4 ng OTA kg bw(-1), except for 1-4-year-olds as a result of their lower body weight. For children, the major contributors of OTA were wheat-based foods followed by oats, rice, and raisins. Beer, coffee, and wine also contributed to total OTA exposure in older individuals. Predicted exposure to OTA decreased when European Commission maximum limits were applied to the occurrence data. The impact on risk for regular eaters of specific commodities was also examined.

  16. Maternal-Fetal Cancer Risk Assessment of Ochratoxin A during Pregnancy

    Science.gov (United States)

    Woo, Chit Shing Jackson; El-Nezami, Hani

    2016-01-01

    Increasing evidence has demonstrated that in utero exposure to environmental chemicals may interfere with fetal development and increase the risk of disease and cancer development later in life. Ochratoxin A (OTA) has been proven to induce diverse toxic effects including teratogenicity, carcinogenicity, immunotoxicity and potential endocrine disruption. Due to the continuous and widespread occurrence of OTA as a potential contaminant of staple foods, there is increasing concern of in utero exposure of fetus to this mycotoxin. In this study, maternal-fetal risk assessment of OTA during pregnancy was conducted using the benchmark dose approach for genotoxic carcinogens. The daily intake of OTA for Egyptian pregnant women was estimated based on their serum OTA level using the refined Klaassen equation for pregnancy. Fetal exposure level was also estimated based on the maternal data. Comparison between the estimated daily exposure and the negligible cancer risk intake (NCRI), and the calculation of margin of exposure (MOE) implicated that OTA exposure from dietary intake would be of low health concern for this general subpopulation of Egyptian women. This subpopulation of pregnant women was generally estimated not to be in high-risk for toxicity induced by OTA. PMID:27023600

  17. Translation, cultural adaptation and content re-validation of the observational teamwork assessment for surgery tool.

    Science.gov (United States)

    Amaya Arias, Ana Carolina; Barajas, Rocío; Eslava-Schmalbach, Javier H; Wheelock, Ana; Gaitán Duarte, Hernando; Hull, Louise; Sevdalis, Nick

    2014-12-01

    Background. Poor teamwork and nontechnical skill performance are increasingly recognized as important contributing factors to errors and adverse events in the operating room. Assessment of these safety critical skills is important to facilitate improvement, however there are no tools available to assess these safety skills in Latin America. This study aimed to translate, culturally adapt and content validate the Observational Teamwork Assessment for Surgery (OTAS) tool for use in Latin America. Methods. A multi-phase, multi-method study was conducted: Phase 1: translation and back-translation; Phase 2: content validity assessed via expert consensus; Phase 3: inter-rater reliability assessed via real-time observation in 98 general surgical procedures using OTAS-S. Results. The first change in OTAS-S, was to distinguish between the surgical nurses and scrub technicians (both OR team members are captured in the nursing sub-team in the original OTAS). OTAS-S consists of 168 exemplar behaviors: 60/114 identical to the exemplars listed in the original OTAS tool, 48/114 original exemplars underwent minor modifications, 13 were duplicated (to account for the additional sub-team distinguished in OTAS-S), 6 original exemplars were removed, and 47 new exemplar behaviors were added. Inter-observer agreement was substantial (KW = 0.602; IC: 0.581-0.620). The calculated KW by phase, behaviors and teams were between 0.534 and 0.678. Conclusions. The study provides a content validated teamwork assessment tool for use within Colombian operating rooms and potentially Latin-American. OTAS-S can be used to assess the quality of teamwork in ORs, facilitate structured debriefing and thus improve patient safety and reduce team-related errors.

  18. Decision Gate Process for Assessment of a NASA Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna L.; Hyatt, Mark J.

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to Technology Readiness Level (TRL) 6) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, to reduce life cycle cost and risk, and to increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product was either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  19. Propulsion Technology Assessment: Science & Enabling Technologies to Explore the Interstellar Medium

    Science.gov (United States)

    Hopkins, Randall C.; Thomas, Herbert D.; Wiegmann, Bruce M.; Heaton, Andrew F.; Johnson, Les; Baysinger, Michael F.; Beers, Benjamin R.

    2015-01-01

    As part of a larger effort led by the Keck Institute for Space Studies at the California Institute of Technology, the Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a study to assess what low-thrust advanced propulsion system candidates, existing and near term, could deliver a small, Voyager-like satellite to our solar system's heliopause, approximately 100 AU from the center of the sun, within 10 years and within a 2025 to 2035 launch window. The advanced propulsion system trade study consisted of three candidates, including a Magnetically Shielded Miniature (MaSMi) Hall thruster, a solar sail and an electric sail. Two aerial densities, and thus characteristic accelerations, 0.426 mm/s2 and 0.664 mm/s2, were analyzed for the solar sail option in order understand the impact of near and long term development of this technology. Similarly, two characteristic accelerations, 1 mm/s2 and 2 mm/s2, were also analyzed for the electric sail option in addition to tether quantities of 10 and 20, respectively, and individual tether length of 20 km. A second analysis was conducted to determine what existing solid rocket motor kick stage(s) would be required to provide additional thrust at various points in the trajectory, assuming an earth departure characteristic energy capability provided by a Space Launch System (SLS) Block 1B vehicle architecture carrying an 8.4 meter payload fairing. Two trajectory profiles were considered, including an escape trajectory using a Jupiter gravity assist (E-Ju), and an escape trajectory first performing a Jupiter gravity assist followed by an Oberth maneuver around the sun and an optional Saturn gravity assist (E-Ju-Su-Sa). The Oberth maneuver would need to be performed very close to the sun, wherein this study assumed a perihelion distance of approximately 11 solar radii, or 0.05 AU, away from the surface. The heat shield technology required to perform this type of ambitious maneuver was assumed to be

  20. Propulsion Technology Assessment: Science and Enabling Technologies to Explore the Interstellar Medium

    Science.gov (United States)

    Hopkins, Randall C.; Thomas, Herbert D.; Wiegmann, Bruce M.; Heaton, Andrew F.; Johnson, Les; Baysinger, Michael F.; Beers, Benjamin R.

    2016-01-01

    Led by the Keck Institute for Space Studies at the California Institute of Technology, the Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a study to assess what low-thrust advanced propulsion system candidates, existing and near term, could deliver a small, Voyager-like satellite to our solar system's heliopause, approximately 100 AU from the center of the sun, within 10 years and within a 2025-2035 launch window. The advanced propulsion system trade study consisted of three candidates, including a Magnetically Shielded Miniature (MaSMi) Hall thruster, a solar sail and an electric sail. Two aerial densities, and thus characteristic accelerations, 0.426 mm/sq s and 0.664 mm/sq s were analyzed for the solar sail option in order understand the impact of near and long term development of this technology. Similarly, two characteristic accelerations, 1 mm/s2 and 2 mm/sq s, were also analyzed for the electric sail option in addition to tether quantities of 10 and 20, respectively, and individual tether length of 20 km. A second analysis was conducted to determine what existing solid rocket motor kick stage(s) would be required to provide additional thrust at various points in the trajectory, assuming an earth departure characteristic energy capability provided by a Space Launch System (SLS) Block 1B vehicle architecture carrying an 8.4 meter payload fairing. Two trajectory profiles were considered, including an escape trajectory using a Jupiter gravity assist (E-Ju), and an escape trajectory first performing a Jupiter gravity assist followed by an Oberth maneuver around the sun and an optional Saturn gravity assist (E-Ju-Su-Sa). The Oberth maneuver would need to be performed very close to the sun, wherein this study assumed a perihelion distance of approximately 11 solar radii, or 0.05 AU, away from the surface. The heat shield technology required to perform this type of ambitious maneuver was assumed to be similar to that of NASA

  1. Propulsion Technology Assessment: Science and Enabling Technologies to Explore the Interstellar Medium

    Science.gov (United States)

    Hopkins, Randall C.; Thomas, Herbert D.; Wiegmann, Bruce M.; Heaton, Andrew F.; Johnson, Les; Baysinger, Michael F.; Beers, Benjamin R.

    2016-01-01

    As part of a larger effort led by the Keck Institute for Space Studies at the California Institute of Technology, the Advanced Concepts Office at NASA’s George C. Marshall Space Flight Center conducted a study to assess what low-thrust advanced propulsion system candidates, existing and near term, could deliver a small, Voyager-like satellite to our solar system’s heliopause, approximately 100 AU from the center of the sun, within 10 years and within a 2025 to 2035 launch window. The advanced propulsion system trade study consisted of three candidates, including a Magnetically Shielded Miniature (MaSMi) Hall thruster, a solar sail and an electric sail. Two aerial densities, and thus characteristic accelerations, 0.426 mm/s(exp 2) and 0.664 mm/s(exp 2), were analyzed for the solar sail option in order understand the impact of near and long term development of this technology. Similarly, two characteristic accelerations, 1 mm/s(exp 2) and 2 mm/s(exp 2), were also analyzed for the electric sail option in addition to tether quantities of 10 and 20, respectively, and individual tether length of 20 km. A second analysis was conducted to determine what existing solid rocket motor kick stage(s) would be required to provide additional thrust at various points in the trajectory, assuming an earth departure characteristic energy capability provided by a Space Launch System (SLS) Block 1B vehicle architecture carrying an 8.4 meter payload fairing. Two trajectory profiles were considered, including an escape trajectory using a Jupiter gravity assist (E-Ju), and an escape trajectory first performing a Jupiter gravity assist followed by an Oberth maneuver around the sun and an optional Saturn gravity assist (E-Ju-Su-Sa). The Oberth maneuver would need to be performed very close to the sun, wherein this study assumed a perihelion distance of approximately 11 solar radii, or 0.05 AU, away from the surface. The heat shield technology required to perform this type of ambitious

  2. Assessing the Role of Technology Adoption in China's Growth Performance

    DEFF Research Database (Denmark)

    Wirz, Nadja

    China has experienced a period of tremendous economic growth in recent years. In an attempt to explain this development, several existing growth-accounting studies reveal that impressively high rates of productivity growth have been at the heart of China's performance. This study investigates...... to what extent these productivity increases can be explained by technology-adoption theory. In less developed countries, the key element behind technological progress is technology adoption, the process of copying technological knowledge invented throughout the world. To uncover a measure of China...

  3. Involving patient in the early stages of health technology assessment (HTA): a study protocol

    OpenAIRE

    Gagnon, Marie-Pierre; Candas, Bernard; Desmartis, Marie; Gagnon, Johanne; Roche, Daniel La; Rhainds, Marc; Coulombe, Martin; Dipankui, Mylène Tantchou; Légaré, France

    2014-01-01

    Background Public and patient involvement in the different stages of the health technology assessment (HTA) process is increasingly encouraged. The selection of topics for assessment, which includes identifying and prioritizing HTA questions, is a constant challenge for HTA agencies because the number of technologies requiring an assessment exceeds the resources available. Public and patient involvement in these early stages of HTA could make assessments more relevant and acceptable to them. ...

  4. Trust, technology affordances and feedback in peer assessments in MOOCs

    DEFF Research Database (Denmark)

    Ringtved, Ulla Lunde; Milligan, Sandra

    2015-01-01

    The preliminary findings in the automated peer assessments in the assessment framework in a MOOC are discussed here. We discuss whether,the assessment frame work underpins pedagogical approaches including feedback and collaboration between the participants. The empirical foundation is research...... on data from a recent MOOC from Melbourne University titled “Teaching and assessing 21st century skills”....

  5. Trust, technology affordances and feedback in peer assessments in MOOCs

    DEFF Research Database (Denmark)

    Ringtved, Ulla Lunde; Milligan, Sandra

    2015-01-01

    The preliminary findings in the automated peer assessments in the assessment framework in a MOOC are discussed here. We discuss whether,the assessment frame work underpins pedagogical approaches including feedback and collaboration between the participants. The empirical foundation is research...... on data from a recent MOOC from Melbourne University titled “Teaching and assessing 21st century skills”....

  6. Natural hazards and technological risk in Russia: the relation assessment

    Directory of Open Access Journals (Sweden)

    E. Petrova

    2005-01-01

    Full Text Available Almost every natural disaster is accompanied by some sort of technological one. A number of studies also show a correlation between technological disasters and various global processes such as solar disturbances, geophysical field variation etc. In this study we attempted to ascertain and codify the relationship between different types of technological disasters and natural hazards. Two types of natural hazards were found, based on their genesis, distribution in time, and impact pattern on the technosphere. Solar and geomagnetic disturbances generally affect technological risk through the failure of automatic machinery and the reduction of operator reliability. They increase the probability of transport accidents, fires, and catastrophic toxic emissions. These types of technological disasters are widely prevalent throughout Russia and in all federal regions. Geological, climatic, hydrological, and other natural hazardous processes increase technological risk through direct mechanical impacts. Their occurrence in space and time depends on the character of the natural process and the specific regional environment. The total number and proportion of technological disasters in federal regions results mainly from the concentration of industrial units and their type, as well as the local natural and social environment. Temporal changes in the number of technological disasters of different groups depend on the prevailing type of natural processes.

  7. Assessing personal disposition of individuals towards technology adoption

    Directory of Open Access Journals (Sweden)

    Irbha Magotra

    2016-06-01

    Full Text Available The present study has attempted to explore personal disposition of individuals towards technology adoption through the development of an index named as Technology Adoption Index. For developing the index, exploratory factor analysis approach has been employed on the sample of 1201 responses collected from the residents of 12 different cities in India. Accordingly, the results of the index have indicated significant role of seven personal traits, namely, optimism, innovativeness, self-efficacy, risk taking propensity, habit, social influence and psychological resilience while manifesting personal disposition of individuals towards technology adoption, i.e., the technology adoption propensity of the individuals. Further, an attempt has also been made to explore the socio-economic characteristics of the individuals possessing distinct level of personal disposition towards technology adoption. Accordingly, the results have unveiled that the personal disposition of the individuals towards technology adoption increases with enhancement in their income and qualification but decreases with enhancement in their age. As a measurement tool, Technology Adoption Index can be used as ready-recknor by practitioners for the identification of technology adoption propensity of the individuals. This will facilitate organizations in developing and designing new products and services which can be readily accepted by the individuals.

  8. Validating the Technology Proficiency Self-Assessment Questionnaire for 21st Century Learning (TPSA C-21)

    Science.gov (United States)

    Christensen, Rhonda; Knezek, Gerald

    2017-01-01

    Accurately measuring levels of technology proficiency in current and future classroom teachers are an important first step toward enhancing comfort level and confidence in integrating technology into the educational environment. The original Technology Proficiency Self-Assessment (TPSA) survey has maintained respectable psychometric properties for…

  9. Assistive Technology Approaches for Large-Scale Assessment: Perceptions of Teachers of Students with Visual Impairments

    Science.gov (United States)

    Johnstone, Christopher; Thurlow, Martha; Altman, Jason; Timmons, Joe; Kato, Kentaro

    2009-01-01

    Assistive technology approaches to aid students with visual impairments are becoming commonplace in schools. These approaches, however, present challenges for assessment because students' level of access to different technologies may vary by school district and state. To better understand what assistive technology tools are used in reading…

  10. Validating the Technology Proficiency Self-Assessment Questionnaire for 21st Century Learning (TPSA C-21)

    Science.gov (United States)

    Christensen, Rhonda; Knezek, Gerald

    2017-01-01

    Accurately measuring levels of technology proficiency in current and future classroom teachers are an important first step toward enhancing comfort level and confidence in integrating technology into the educational environment. The original Technology Proficiency Self-Assessment (TPSA) survey has maintained respectable psychometric properties for…

  11. Assessing security technology's impact: old tools for new problems.

    Science.gov (United States)

    Kreissl, Reinhard

    2014-09-01

    The general idea developed in this paper from a sociological perspective is that some of the foundational categories on which the debate about privacy, security and technology rests are blurring. This process is a consequence of a blurring of physical and digital worlds. In order to define limits for legitimate use of intrusive digital technologies, one has to refer to binary distinctions such as private versus public, human versus technical, security versus insecurity to draw differences determining limits for the use of surveillance technologies. These distinctions developed in the physical world and are rooted in a cultural understanding of pre-digital culture. Attempts to capture the problems emerging with the implementation of security technologies using legal reasoning encounter a number of problems since law is by definition oriented backwards, adapting new developments to existing traditions, whereas the intrusion of new technologies in the physical world produces changes and creates fundamentally new problems.

  12. Global Assessment of Hydrogen Technologies - Task 1 Report Technology Evaluation of Hydrogen Light Duty Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Fouad, Fouad H.; Peters, Robert W.; Sisiopiku, Virginia P.; Sullivan Andrew J.; Rousseau, Aymeric

    2007-12-01

    This task analyzes the candidate hydrogen-fueled vehicles for near-term use in the Southeastern U.S. The purpose of this work is to assess their potential in terms of efficiency and performance. This report compares conventional, hybrid electric vehicles (HEV) with gasoline and hydrogen-fueled internal combustion engines (ICEs) as well as fuel cell and fuel cell hybrids from a technology as well as fuel economy point of view. All the vehicles have been simulated using the Powertrain System Analysis Toolkit (PSAT). First, some background information is provided on recent American automotive market trends and consequences. Moreover, available options are presented for introducing cleaner and more economical vehicles in the market in the future. In this study, analysis of various candidate hydrogen-fueled vehicles is performed using PSAT and, thus, a brief description of PSAT features and capabilities are provided. Detailed information on the simulation analysis performed is also offered, including methodology assumptions, fuel economic results, and conclusions from the findings.

  13. Assessment and characterisation of yeast-based products intended to mitigate ochratoxin exposure using in vitro and in vivo models.

    Science.gov (United States)

    Pfohl-Leszkowicz, A; Hadjeba-Medjdoub, K; Ballet, N; Schrickx, J; Fink-Gremmels, J

    2015-01-01

    The aim of this paper was to evaluate the capacity of several yeast-based products, derived from baker's and brewer's yeasts, to sequester the mycotoxin ochratoxin A (OTA) and to decrease its rate of absorption and DNA adduct formation in vivo. The experimental protocol included in vitro binding studies using isotherm models, in vivo chicken experiments, in which the serum and tissue concentrations of OTA were analysed in the absence and presence of the test compounds, and the profile of OTA-derived metabolites and their associated DNA adducts were determined. Additionally in vitro cell culture studies (HK2 cells) were applied to assess further the effects for yeast cell product enriched with glutathione (GSH) or selenium. Results of the in vitro binding assay in a buffer system indicated the ability of the yeast-based products, as sequester of OTA, albeit at a different level. In the in vitro experiments in chickens, decreased serum and tissue concentrations of treated animals confirmed that yeast-based products are able to prevent the absorption of OTA. A comparison of the binding affinity in a standard in vitro binding assay with the results obtained in an in vivo chicken experiment, however, showed a poor correlation and resulted in a different ranking of the products. More importantly, we could show that yeast-based products actively modulate the biotransformation of OTA in vivo as well as in vitro in a cell culture model. This effect seems to be attributable to residual enzymatic activities in the yeast-based products. An enrichment of yeast cell wall products with GSH or selenium further modulated the profile of the generated OTA metabolites and the associated pattern of OTA-induced DNA adducts by increasing the conversion of OTA into less toxic metabolites such as OTA, OTB and 4-OH-OTA. A reduced absorption and DNA adduct formation was particularly observed with GSH-enriched yeast, whereas selenium-enriched yeasts could counteract the OTA-induced decrease

  14. What Can You Learn in Three Minutes? Critical Reflection on an Assessment Task that Embeds Technology

    Science.gov (United States)

    Brown, Natalie Ruth

    2009-01-01

    Purpose: The purpose of this paper is to critically examine an assessment task, undertaken by pre-service science teachers, that integrates the use of technology (in this case digital video-recorders and video-editing software) whilst scaffolding skill development. The embedding of technology into the assessment task is purposeful, aiming to…

  15. Vocal Sight-Reading Assessment: Technological Advances, Student Perceptions, and Instructional Implications

    Science.gov (United States)

    Henry, Michele

    2015-01-01

    This study investigated choral singers' comfort level using computer technology for vocal sight-reading assessment. High school choral singers (N = 138) attending a summer music camp completed a computer-based sight-reading assessment and accompanying pre- and posttest surveys on their musical backgrounds and perceptions about technology. A large…

  16. Stop looking up the ladder: analyzing the impact of participatory technology assessment from a network perspective

    NARCIS (Netherlands)

    Loeber, A.; Griessler, E.; Versteeg, W.

    2011-01-01

    Alongside the gradual increase in use of participatory technology assessment (PTA), a tool to democratize decision-making on controversial technologies, a growing body of literature on how to assess the impact of PTA has developed. A distinction can be made between two generations of impact assessme

  17. Study design for concurrent development, assessment, and implementation of new diagnostic imaging technology

    NARCIS (Netherlands)

    M.G.M. Hunink (Myriam); G.P. Krestin (Gabriel)

    2002-01-01

    textabstractWith current constraints on health care resources and emphasis on value for money, new diagnostic imaging technologies must be assessed and their value demonstrated. The state of the art in the field of diagnostic imaging technology assessment advocates a hierarchical

  18. The Impact of the Technology Used in Formative Assessment: The Case of Spelling

    Science.gov (United States)

    Vásquez, Andrea; Nussbaum, Miguel; Sciarresi, Enzo; Martínez, Tomás; Barahona, Camila; Strasser, Katherine

    2017-01-01

    This study demonstrates how the technology used to assist formative assessment in spelling can have an impact on learning. Formative assessment represents a set of student-centered practices, the results of which are not always optimal. Furthermore, different technologies are better suited to certain tasks than to others. The study follows a…

  19. The Impact of the Technology Used in Formative Assessment: The Case of Spelling

    Science.gov (United States)

    Vásquez, Andrea; Nussbaum, Miguel; Sciarresi, Enzo; Martínez, Tomás; Barahona, Camila; Strasser, Katherine

    2017-01-01

    This study demonstrates how the technology used to assist formative assessment in spelling can have an impact on learning. Formative assessment represents a set of student-centered practices, the results of which are not always optimal. Furthermore, different technologies are better suited to certain tasks than to others. The study follows a…

  20. ECITE: A Testbed for Assessment of Technology Interoperability and Integration wiht Architecture Components

    Science.gov (United States)

    Graves, S. J.; Keiser, K.; Law, E.; Yang, C. P.; Djorgovski, S. G.

    2016-12-01

    ECITE (EarthCube Integration and Testing Environment) is providing both cloud-based computational testing resources and an Assessment Framework for Technology Interoperability and Integration. NSF's EarthCube program is funding the development of cyberinfrastructure building block components as technologies to address Earth science research problems. These EarthCube building blocks need to support integration and interoperability objectives to work towards a coherent cyberinfrastructure architecture for the program. ECITE is being developed to provide capabilities to test and assess the interoperability and integration across funded EarthCube technology projects. EarthCube defined criteria for interoperability and integration are applied to use cases coordinating science problems with technology solutions. The Assessment Framework facilitates planning, execution and documentation of the technology assessments for review by the EarthCube community. This presentation will describe the components of ECITE and examine the methodology of cross walking between science and technology use cases.

  1. Bridges between science, society and policy technology assessment : methods and impacts

    CERN Document Server

    Ladikas, Miltos

    2004-01-01

    This book summarises the results of the project TAMI (Technology Assessment in Europe; between Method and Impact). This was a two-year project that brought together the main institutes of technology assessment in Europe, both parliamentary and non-parliamentary. TAMI created a structured dialogue between technology assessment experts and policymakers on current methodologies and their impact on policymaking. The TAMI team explored and assessed the whole spectrum of methodologies from the "classical" to the "interactive/participatory" and "communicative," identified good practices in project implementation and set the stage for impact evaluation based on objective criteria. Finally this report offers a series of policy recommendations based on the findings of the project. Science, Society and Policy, are three areas that technology assessment functions within and works for; this book is an attempt to improve the interaction amongst them for a more socially and economically sustainable Science and Technology p...

  2. Uncertainties related to the identification of the marginal energy technology in consequential life cycle assessments

    DEFF Research Database (Denmark)

    Mathiesen, B.V.; Münster, Marie; Fruergaard, Thilde

    2009-01-01

    When performing life cycle assessment (LCA) assumptions regarding the energy use are often decisive for the outcome. In this paper, current approaches of identifying marginal electricity and heat technologies for consequential LCAs are challenged. The identification of marginal energy technologies...... is examined from three angles: The marginal electricity technology is identified in Danish historical and potential future energy systems. The methods of identifying and using marginal electricity and heat technologies in key LCA studies are analysed. Finally, the differences in applying energy system...

  3. Assessing Expectations: Towards a Toolbox for an Ethics of Emerging Technologies.

    Science.gov (United States)

    Lucivero, Federica; Swierstra, Tsjalling; Boenink, Marianne

    2011-08-01

    In recent years, several authors have argued that the desirability of novel technologies should be assessed early, when they are still emerging. Such an ethical assessment of emerging technologies is by definition focused on an elusive object. Usually promises, expectations, and visions of the technology are taken as a starting point. As Nordmann and Rip have pointed out in a recent article, however, ethicists should not take for granted the plausibility of such expectations and visions. In this paper, we explore how the quality of expectations on emerging technologies might be assessed when engaging in a reflection on the desirability of emerging technologies. We propose that an assessment of expectations' plausibility should focus on statements on technological feasibility, societal usability, and desirability of the expected technology. Whereas the feasibility statement and, to a lesser extent, the usability statements are frequently quite futuristic, the claims on desirability, by contrast, often display a conservative stance towards the future. Assessing the quality of expectations and visions on behalf of emerging technologies requires, then, a careful and well-directed use of both skepticism and imagination. We conclude with a brief overview of the tools and methods ethicists could use to assess claims made on behalf of emerging technologies and improve the ethical reflection on them.

  4. Some implications of the technology assessment function for the effective public decision-making process

    Science.gov (United States)

    Mayo, L. H.

    1971-01-01

    A preliminary provisional assessment of the prospects for the establishment of an adequate technology assessment function and the implications of the assessment function for the public decision process are presented. Effects of the technology assessment function on each phase of the public decision process and briefly explored. Significant implications during the next decade are projected with respect to the following phases: invention and development of alternative means (technological configurations); evaluation, selection and promotion of preferred courses of action; and modification of statutory scheme or social action program as an outcome of continuing monitoring and appraisal.

  5. An Assessment of Petroleum Technology Development Fund (Ptdf ...

    African Journals Online (AJOL)

    Journal Home > Vol 5 (2008) > ... The importance of indigenous technological training and skill development in ... of providing scholarships, bursaries, training or education in petroleum in any of the higher institutions in Nigeria and abroad.

  6. Technology Assessment of Dust Suppression Techniques Applied During Structural Demolition

    Energy Technology Data Exchange (ETDEWEB)

    Boudreaux, J.F.; Ebadian, M.A.; Williams, P.T.; Dua, S.K.

    1998-10-20

    Hanford, Fernald, Savannah River, and other sites are currently reviewing technologies that can be implemented to demolish buildings in a cost-effective manner. In order to demolish a structure properly and, at the same time, minimize the amount of dust generated from a given technology, an evaluation must be conducted to choose the most appropriate dust suppression technology given site-specific conditions. Thus, the purpose of this research, which was carried out at the Hemispheric Center for Environmental Technology (HCET) at Florida International University, was to conduct an experimental study of dust aerosol abatement (dust suppression) methods as applied to nuclear D and D. This experimental study targeted the problem of dust suppression during the demolition of nuclear facilities. The resulting data were employed to assist in the development of mathematical correlations that can be applied to predict dust generation during structural demolition.

  7. Red Team Operations to Assess Information Technology Vulnerabilities

    NARCIS (Netherlands)

    Veltman, M.; Parker, R.L.

    1999-01-01

    All Information and Communication Technology (ICT) systems have vulnerabilities. Weaknesses in these systems are introduced either during the specification, implementation or operational phase. Leaving aside these introduced vulnerabilities are intentional or unintentional, the fact remains that the

  8. Technology Needs Assessment in the Home Garden Systems

    Directory of Open Access Journals (Sweden)

    Allan Thomas

    2016-07-01

    Full Text Available The study was conducted in the four districts of Kerala covering a sample size of 208 homegardens using multi-stage stratified random sampling technique representing the three major agro climatic zones viz. lowland (problem zone, highland and midland. The primary objective of the study was to identify the technology needs of the homegarden farmers. Maximum technology need was reported for unexploited and under exploited horticultural tree crops which was on par with fruit tree crops (mango and jack and followed by beverage crops. Processing, value addition and storage requirements were immediate technology needs of the homegarden farmers. Drainage and soil amendment technologies were reported to be important for Alappuzha homegarden farmers.

  9. Prediction technologies for assessment of climate change impacts

    Science.gov (United States)

    Temperatures, precipitation, and weather patterns are changing, in response to increasing carbon dioxide in the atmosphere. With these relatively rapid changes, existing soil erosion prediction technologies that rely upon climate stationarity are potentially becoming less reliable. This is especiall...

  10. EVALUATION OF CURRENT SUSTAINABILITY ASSESSMENT OF BIOBASED TECHNOLOGY

    Science.gov (United States)

    Sustainable technology is driven by economic competitiveness, government policies and public pressure. The claim of inherent cleanliness for biotechnology is too simplistic. Each application of biotechnology must be evaluated for suitable characteristics of sustainability. The ...

  11. A Conceptual Decision Methodology for High Technology Transfer Assessment.

    Science.gov (United States)

    1982-05-01

    review and provide input within given time periods on selected technologies. The basic industrial export control mechanism continues to be centered in...Department of Commerce is the center of the export control system, it is by no means predominate in the control of all exports. True, it is a key...Department of State endorsed the venture as, "in the national interest." The technology was promised during the Nixon- Pompidou Summit in the Azores. Without

  12. NASA Langley Systems Analysis & Concepts Directorate Technology Assessment/Portfolio Analysis

    Science.gov (United States)

    Cavanaugh, Stephen; Chytka, Trina; Arcara, Phil; Jones, Sharon; Stanley, Doug; Wilhite, Alan W.

    2006-01-01

    Systems analysis develops and documents candidate mission and architectures, associated system concepts, enabling capabilities and investment strategies to achieve NASA s strategic objectives. The technology assessment process connects the mission and architectures to the investment strategies. In order to successfully implement a technology assessment, there is a need to collect, manipulate, analyze, document, and disseminate technology-related information. Information must be collected and organized on the wide variety of potentially applicable technologies, including: previous research results, key technical parameters and characteristics, technology readiness levels, relationships to other technologies, costs, and potential barriers and risks. This information must be manipulated to facilitate planning and documentation. An assessment is included of the programmatic and technical risks associated with each technology task as well as potential risk mitigation plans. Risks are assessed and tracked in terms of likelihood of the risk occurring and consequences of the risk if it does occur. The risk assessments take into account cost, schedule, and technical risk dimensions. Assessment data must be simplified for presentation to decision makers. The Systems Analysis and Concepts Directorate (SACD) at NASA Langley Research Center has a wealth of experience in performing Technology Assessment and Portfolio Analysis as this has been a business line since 1978.

  13. Assessment of Technologies for Noncryogenic Hybrid Electric Propulsion

    Science.gov (United States)

    Dever, Timothy P.; Duffy, Kirsten P.; Provenza, Andrew J.; Loyselle, Patricia L.; Choi, Benjamin B.; Morrison, Carlos R.; Lowe, Angela M.

    2015-01-01

    The Subsonic Fixed Wing Project of NASA's Fundamental Aeronautics Program is researching aircraft propulsion technologies that will lower noise, emissions, and fuel burn. One promising technology is noncryogenic electric propulsion, which could be either hybrid electric propulsion or turboelectric propulsion. Reducing dependence on the turbine engine would certainly reduce emissions. However, the weight of the electricmotor- related components that would have to be added would adversely impact the benefits of the smaller turbine engine. Therefore, research needs to be done to improve component efficiencies and reduce component weights. This study projects technology improvements expected in the next 15 and 30 years, including motor-related technologies, power electronics, and energy-storage-related technologies. Motor efficiency and power density could be increased through the use of better conductors, insulators, magnets, bearings, structural materials, and thermal management. Energy storage could be accomplished through batteries, flywheels, or supercapacitors, all of which expect significant energy density growth over the next few decades. A first-order approximation of the cumulative effect of each technology improvement shows that motor power density could be improved from 3 hp/lb, the state of the art, to 8 hp/lb in 15 years and 16 hp/lb in 30 years.

  14. Development of the public information and communication technology assessment tool.

    Science.gov (United States)

    Ripat, Jacquie; Watzke, James; Birch, Gary

    2008-09-01

    Public information and communication technologies, such as information kiosks, automated banking machines and ticket dispensers, allow people to access services in a convenient and timely manner. However, the development of these technologies has occurred largely without consideration of access by people with disabilities. Inaccessible technical features make operation of a public technology difficult and barriers in the environment create navigational challenges, limiting the opportunity of people with disabilities to use these devices and access the services they provide. This paper describes the development of a tool that individuals, disability advocacy groups, business owners, healthcare providers, and urban planners can use to evaluate the accessibility of public technologies and the surrounding environment. Evaluation results can then be used to develop recommendations and advocate for technical and environmental changes to improve access. Tool development consisted of a review of the literature and key Canadian Standards Association documents, task analysis, and consultation with accessibility experts. Studies of content validity, tool usability, inter-rater and test-retest reliability were conducted in sites across Canada. Accessibility experts verified the content validity of the tool. The current version of the tool has incorporated the findings of a usability study. Initial testing indicated excellent agreement for inter-rater and test-retest reliability scores. Social exclusion can arise when public technologies are not accessible. This newly developed instrument provides detailed information that can be used to advocate for more accessible and inclusive public information and communication technologies.

  15. A model for technology assessment and commercialization for innovative disruptive technologies

    Energy Technology Data Exchange (ETDEWEB)

    KASSICIEH, SULEIMAN K.; WALSH, STEVE; MCWHORTER,PAUL J.; CUMMINGS JR.,JOHN C.; WILLIAMS,W. DAVID; ROMIG JR.,ALTON D.

    2000-05-17

    Disruptive technologies are scientific discoveries that break through the usual product technology capabilities and provide a basis for a new competitive paradigm as described by Anderson and Tushman [1990], Tushman and Rosenkopf [1992], and Bower and Christensen [1995]. Discontinuous innovations are products/processes/services that provide exponential improvements in the value received by the customer much in the same vein as Walsh [1996], Lynn, Morone and Paulson [1996], and Veryzer [1998]. For more on definitions of disruptive technologies and discontinuous innovations, see Walsh and Linton [1999] who provide a number of definitions for disruptive technologies and discontinuous innovations. Disruptive technologies and discontinuous innovations present a unique challenge and opportunity for R and D organizations seeking to build their commercialization efforts and to reinvent the corporation. These technologies do not have a proven path from scientific discovery to mass production and therefore require novel approaches. These critically important technologies are the wellspring of wealth creation and new competency generation but are not readily accepted by the corporate community. They are alternatively embraced and eschewed by the commercial community. They are finally accepted when the technology has already affected the industry or when the technological horse has already flown out of the hanger. Many firms, especially larger firms, seem reluctant to familiarize themselves with these technologies quickly. The trend seems to be that these firms prefer to react to a proven disruptive technology that has changed the product market paradigm. If true, then there is cause for concern. This paper will review the literature on disruptive technologies presenting a model of the progression from scientific idea to mass production for disruptive technologies contrasted to the more copious incremental technologies. The paper will then describe Sandia National Laboratories

  16. Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus.

    Science.gov (United States)

    Gerami, Pedram; Pouryazdanparast, Pedram; Vemula, Swapna; Bastian, Boris C

    2010-05-01

    Nevus of Ota is a variant of congenital nevus, which is morphologically paucicellular and resembles a common blue nevus. Although nevus of Ota is a risk factor for uveal melanoma in white people, the development of cutaneous melanoma within nevus of Ota is a very rare occurrence with only a few reported cases. We present a case of a long-standing nevus of Ota, with radiologic imaging demonstrating a large retro-orbital mass and a biopsy showing melanoma. The histopathology of the eye exenteration specimen illustrated various stages of melanocytic progression including areas resembling a nevus of Ota, blue nevus, cellular blue nevus, and melanoma. There was heterogeneity in the overtly malignant sections with some areas displaying expansile nodules of blander appearing spindled cells, whereas other areas were composed of epithelioid cells with higher mitotic counts and zones of necrosis. The extensive lesion also infiltrated the soft tissue and bone. We performed gene mutation analysis for GNAQ, BRAF, NRAS, and KIT and fluorescence in situ hybridization (FISH) targeting commonly altered chromosomal loci in melanoma and comparative genomic hybridization (CGH). Copy number changes typical of melanoma were identified by both FISH and CGH in the morphologically malignant areas illustrating the relationship of tumor progression and the progressive acquisition of genetic aberrations.

  17. Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

    Directory of Open Access Journals (Sweden)

    Amiya Kumar Mukhopadhyay

    2013-01-01

    Full Text Available Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino′s classification to incorporate the nevus of Ito into the classification for the Ota′s nevus may be appropriate.

  18. Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota.

    Science.gov (United States)

    Navas, Marta; Pascual, José M; Fraga, Javier; Pedrosa, Manuel; Shakur, Sophia; Carrasco, Rodrigo; Martínez, Pedro; Manzanares, Rafael; de Sola, Rafael García

    2009-10-01

    Solitary primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of lesions ranging from well-differentiated melanocytoma to melanoma. The association of a meningeal melanocytoma with an ipsilateral nevus of Ota is extremely rare, with only six cases reported in the literature to date. Only a minority of melanocytic tumors correspond to lesions of intermediate-grade malignancy, whose biological behavior and outcome remain undetermined. We report a new case of a 25-year-old man with a giant fronto-temporal intracranial meningeal melanocytoma associated with a congenital nevus of Ota, who suffered an acute neurological deterioration requiring an emergent surgical procedure. Despite total removal of the lesion, the patient did not recover from the operation due to a malignant infarct of the right hemisphere. The lesion showed no histological criteria of malignancy but did exhibit an elevated (8%) MIB-1/Ki-67 cell proliferative index, which suggested an intermediate-grade melanocytoma. In addition, its metabolic profile, determined by in vivo proton magnetic resonance spectroscopy (MRS), was similar to that observed in most high-grade gliomas. To our knowledge, this is the first case of a meningeal melanocytoma of intermediate grade associated with a nevus of Ota reported in the literature. Only two additional intermediate-grade melanocytomas showing an elevated MIB-1/Ki-67 labeling index have been previously reported. The MIB-1/Ki-67 labeling index may have potential prognostic value in helping the clinician to predict an aggressive clinical behavior and/or malignant progression for primary melanocytic neoplasms of the CNS.

  19. Implementation of fuzzy system using different voltages of OTA for JNK pathway leading to cell survival/ death

    Directory of Open Access Journals (Sweden)

    Shruti Jain

    2015-06-01

    Full Text Available In this paper a well defined method for the design of JNK pathway for epidermal growth factor/ insulin using fuzzy system using operational transconductance amplifier was discussed. Fuzzy system includes fuzzification of the input variables, application of the fuzzy operator (AND or OR in the antecedent, implication from the antecedent to the consequent, aggregation of the consequents across the rules, and defuzzfication. Fuzzy system with various electrical parameters for different voltages of OTA with different membership function was found. Results with 3V were the best.

  20. SEMICONDUCTOR INTEGRATED CIRCUITS: A reconfigurable OTA-C baseband filter with wide digital tuning for GNSS receivers

    Science.gov (United States)

    Wenguang, Pan; Chengyan, Ma; Yebing, Gan; Tianchun, Ye

    2010-09-01

    The design of a digitally-tunable sixth-order reconfigurable OTA-C filter in a 0.18-μm RFCMOS process is proposed. The filter can be configured as a complex band pass filter or two real low pass filters. An improved digital automatic frequency tuning scheme based on the voltage controlled oscillator technique is adopted to compensate for process variations. An extended tuning range (above 8:1) is obtained by using widely continuously tunable transcon-ductors based on digital techniques. In the complex band pass mode, the bandwidth can be tuned from 3 to 24 MHz and the center frequency from 3 to 16 MHz.