WorldWideScience

Sample records for technology asc borrows

  1. Advanced Stirling Convertor (ASC) Technology Maturation

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Scott; Collins, Josh; Wilson, Kyle

    2016-01-01

    The Advanced Stirling Convertor (ASC) development effort was initiated by NASA Glenn Research Center with contractor Sunpower, Inc., to develop high-efficiency thermal-to-electric power conversion technology for NASA Radioisotope Power Systems (RPSs). Early successful performance demonstrations led to the expansion of the project as well as adoption of the technology by the Department of Energy (DOE) and system integration contractor Lockheed Martin Space Systems Company as part of the Advanced Stirling Radioisotope Generator (ASRG) flight project. The ASRG integrates a pair of ASCs to convert the heat from a pair of General Purpose Heat Source (GPHS) modules into electrical power. The expanded NASA ASC effort included development of several generations of ASC prototypes or engineering units to help prepare the ASC technology and Sunpower for flight implementation. Sunpower later had two parallel contracts allowing the last of the NASA engineering units called ASC-E3 to serve as pathfinders for the ASC-F flight convertors being built for DOE. The ASC-E3 convertors utilized the ASC-F flight specifications and were built using the ASC-F design and process documentation. Shortly after the first ASC-F pair achieved initial operation, due to budget constraints, the DOE ASRG flight development contract was terminated. NASA continues to invest in the development of Stirling RPS technology including continued production of the ASC-E3 convertors, seven of which have been delivered with one additional unit in production. Starting in fiscal year 2015, Stirling Convertor Technology Maturation has been reorganized as an element of the RPS Stirling Cycle Technology Development (SCTD) Project and long-term plans for continued Stirling technology advancement are in reformulation. This paper provides a status on the ASC project, an overview of advancements made in the design and production of the ASC at Sunpower, and a summary of acceptance tests, reliability tests, and tactical

  2. Advanced Stirling Convertor (ASC)--From Technology Development to Future Flight Product

    Science.gov (United States)

    Wong, Wayne A.; Wood, J. Gary; Wilson, Kyle

    2008-01-01

    The Advanced Stirling Convertor (ASC) is being developed by Sunpower Inc. under contract to NASA s Glenn Research Center (GRC) with critical technology support tasks led by GRC. The ASC development, funded by NASA s Science Mission Directorate, started in 2003 as one of 10 competitively awarded contracts that were intended to address the power conversion needs of future Radioisotope Power Systems (RPS). The ASC technology has since evolved through progressive convertor builds and successful testing to demonstrate high conversion efficiency (38 percent), low mass (1.3 kg), hermetic sealing, launch vibration simulation, EMI characterization, and is undergoing extended operation. The GRC and Sunpower team recently delivered two ASC-E convertors to the Department of Energy (DOE) and Lockheed Martin Space Systems Company for integration onto the Advanced Stirling Radioisotope Generator Engineering Unit (ASRG EU) plus one spare. The design of the next build, called the ASC-E2, has recently been initiated and is based on the heritage ASC-E with design refinements to increase reliability margin and offer higher temperature operation and improve performance. The ASC enables RPS system specific power of about 7 to 8 W/kg. This paper provides a chronology of ASC development to date and summarizes technical achievements including advancements toward flight implementation of the technology on ASRG by as early as 2013.

  3. Advanced Stirling Convertor (ASC) - From Technology Development to Future Flight Product

    Science.gov (United States)

    Wong, Wayne A.; Wood, J. Gary; Wilson, Kyle

    2008-01-01

    The Advanced Stirling Convertor (ASC) is being developed by Sunpower, Inc. under contract to NASA s Glenn Research Center (GRC) with critical technology support tasks lead by GRC. The ASC development, funded by NASA s Science Mission Directorate, started in 2003 as one of 10 competitively awarded contracts that were to address future Radioisotope Power System (RPS) advanced power conversion needs. The ASC technology has since evolved through progressive convertor builds and successful testing to demonstrate high conversion efficiency (38 %), low mass (1.3 kg), hermetic sealing, launch vibration simulation, EMI characterization, and is undergoing extended operation. The GRC and Sunpower team recently delivered three ASC-E machines to the Department of Energy (DOE) and Lockheed Martin Space Systems Company, two units for integration onto the Advanced Stirling Radioisotope Generator Engineering Unit (ASRG EU) plus one spare. The design has recently been initiated for the ASC-E2, an evolution from the ASC-E that substitutes higher temperature materials enabling improved performance and higher reliability margins. This paper summarizes the history and status of the ASC project and discusses plans for this technology which enables RPS specific power of 8 W/kg for future NASA missions.

  4. Emerging Technologies: Something Borrowed, Something New

    Science.gov (United States)

    Heinhorst, Sabine; Cannon, Gordon

    1999-04-01

    The cover of the July 16, 1998 issue of Nature features a remarkable new "smart material" that can be used to print electronically on a variety of surfaces, including paper, plastic, and metal. The electrophoretic ink developed in J. Jacobson's lab at the Massachusetts Institute of Technology consists of liquid with dispersed, oppositely charged black and white microparticles that are contained in microcapsules. Application of a potential results in migration of the microparticles to opposite sides of the microcapsule, thereby generating either a white or black image that depends on the direction of the potential. Unlike liquid crystal displays, the image generated with electrophoretic ink is stable even after the power has been turned off. Cost and resolution of this new technology compare favorably with most other electronic image display systems currently in use or under development. Promising applications for electrophoretic ink in the future may range from street signs to electronic books (Comiskey et al., Vol. 394, pp 253-255; "News and Views" commentary by R. Wisnieff on pp 225-227).

  5. ASC-1

    DEFF Research Database (Denmark)

    Jakimoski, Goce; Khajuria, Samant

    2011-01-01

    The goal of the modes of operation for authenticated encryption is to achieve faster encryption and message authentication by performing both the encryption and the message authentication in a single pass as opposed to the traditional encrypt-then-mac approach, which requires two passes....... Unfortunately, the use of a block cipher as a building block limits the performance of the authenticated encryption schemes to at most one message block per block cipher evaluation. In this paper, we propose the authenticated encryption scheme ASC-1 (Authenticating Stream Cipher One). Similarly to LEX, ASC-1...... uses leak extraction from diÆerent AES rounds to compute the key material that is XOR-ed with the message to compute the ciphertext. Unlike LEX, the ASC-1 operates in a CFB fashion to compute an authentication tag over the encrypted message. We argue that ASC-1 is secure by reducingits (IND-CCA , INT...

  6. ASC-1

    DEFF Research Database (Denmark)

    Jakimoski, Goce; Khajuria, Samant

    2011-01-01

    The goal of the modes of operation for authenticated encryption is to achieve faster encryption and message authentication by performing both the encryption and the message authentication in a single pass as opposed to the traditional encrypt-then-mac approach, which requires two passes. Unfortun......The goal of the modes of operation for authenticated encryption is to achieve faster encryption and message authentication by performing both the encryption and the message authentication in a single pass as opposed to the traditional encrypt-then-mac approach, which requires two passes...... uses leak extraction from diÆerent AES rounds to compute the key material that is XOR-ed with the message to compute the ciphertext. Unlike LEX, the ASC-1 operates in a CFB fashion to compute an authentication tag over the encrypted message. We argue that ASC-1 is secure by reducingits (IND-CCA , INT...

  7. Pathfinding the Flight Advanced Stirling Convertor Design with the ASC-E3

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Kyle; Smith, Eddie; Collins, Josh

    2012-01-01

    The Advanced Stirling Convertor (ASC) was initially developed by Sunpower, Inc. under contract to NASA Glenn Research Center (GRC) as a technology development project. The ASC technology fulfills NASA's need for high efficiency power convertors for future Radioisotope Power Systems (RPS). Early successful technology demonstrations between 2003 to 2005 eventually led to the expansion of the project including the decision in 2006 to use the ASC technology on the Advanced Stirling Radioisotope Generator (ASRG). Sunpower has delivered 22 ASC convertors of progressively mature designs to date to GRC. Currently, Sunpower with support from GRC, Lockheed Martin Space System Company (LMSSC), and the Department of Energy (DOE) is developing the flight ASC-F in parallel with the ASC-E3 pathfinders. Sunpower will deliver four pairs of ASC-E3 convertors to GRC which will be used for extended operation reliability assessment, independent validation and verification testing, system interaction tests, and to support LMSSC controller verification. The ASC-E3 and -F convertors are being built to the same design and processing documentation and the same product specification. The initial two pairs of ASC-E3 are built before the flight units and will validate design and processing changes prior to implementation on the ASC-F flight convertors. This paper provides a summary on development of the ASC technology and the status of the ASC-E3 build and how they serve the vital pathfinder role ahead of the flight build for ASRG. The ASRG is part of two of the three candidate missions being considered for selection for the Discovery 12 mission.

  8. ASC Champ Orbit Model

    DEFF Research Database (Denmark)

    Riis, Troels; Jørgensen, John Leif

    1999-01-01

    This documents describes a test of the implementation of the ASC orbit model for the Champ satellite.......This documents describes a test of the implementation of the ASC orbit model for the Champ satellite....

  9. Advanced Stirling Convertor (ASC) Development for NASA RPS

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Scott; Collins, Josh

    2014-01-01

    Sunpower's Advanced Stirling Convertor (ASC) initiated development under contract to the NASA Glenn Research Center (GRC) and after a series of successful demonstrations, the ASC began transitioning from a technology development project to flight development project. The ASC has very high power conversion efficiency making it attractive for future Radioisotope Power Systems (RPS) in order to make best use of the low plutonium-238 fuel inventory in the U.S. In recent years, the ASC became part of the NASA-Department of Energy Advanced Stirling Radioisotope Generator (ASRG) Integrated Project. Sunpower held two parallel contracts to produce ASC convertors, one with the Department of Energy/Lockheed Martin to produce the ASC-F flight convertors, and one with NASA GRC for the production of ASC-E3 engineering units, the initial units of which served as production pathfinders. The integrated ASC technical team successfully overcame various technical challenges that led to the completion and delivery of the first two pairs of flight-like ASC-E3 by 2013. However, in late Fall 2013, the DOE initiated termination of the Lockheed Martin ASRG flight development contract driven primarily by budget constraints. NASA continues to recognize the importance of high efficiency ASC power conversion for RPS and continues investment in the technology including the continuation of ASC-E3 production at Sunpower and the assembly of the ASRG Engineering Unit #2. This paper provides a summary of ASC technical accomplishments, overview of tests at GRC, plans for continued ASC production at Sunpower, and status of Stirling technology development.

  10. Survey of Medical Literature Borrowed from the National Lending Library for Science and Technology *

    Science.gov (United States)

    Wood, David N.; Bower, Cathryn A.

    1969-01-01

    This paper reports the results of a four-week questionnaire survey carried out at the National Lending Library (N.L.L.), Great Britian, to discover which types of organizations were the principal users of medical literature, what types of literature were used, and which were the main sources of references to medical publications. Industrial organizations and universities accounted for the majority (62 percent) of the loans, most of which were English-language periodicals published since 1960. For the whole sample, citation lists in periodical articles were the principal sources of references, although for literature published in the last fifteen months, abstracting and indexing journals were the main sources. Of the latter, Index Medicus proved to be the most fruitful source of references. By asking whether the item requested was really useful to their work, a measure of the reliability of the different sources of references was obtained. Appendixes include the questionnaire, a list of the most frequently borrowed journals, and a list of abstracting and indexing journals used as sources of references. PMID:5782264

  11. THE ANALYSIS OF ENGLISH LOAN AND BORROWING WORDS USED BY INFORMATION AND TECHNOLOGY WRITERS IN THESIS ABSTRACTS

    Directory of Open Access Journals (Sweden)

    Luh Mas Ariyati

    2014-11-01

    Full Text Available An analysis on a field of linguistics that is English loan words can cause problems, such as problems of spelling and pronunciation, or even the change in meaning of the English borrowed words. This research is expected to give contribution to the society in general should be aware of the practical use of English loan words in Indonesian. In particular, the IT people can spell and write all the English borrowed words correctly in their writing in accordance with the rules of EYD, especially in formal writing. For EFL teachers and students, this study is aimed to explain practical inputs in teaching ESP writing, loan words, and the development of loan words in relation to linguistics, particularly loan words, such as definitions of loan words, patterns of borrowing and reasons for borrowing. Furthermore, the Indonesian lexicologist, can use the findings of the study to develop the glosarium into comprehensive IT dictionary deriving from English words including how to spell and pronounce them correctly.

  12. Chinese Borrowings in English

    Institute of Scientific and Technical Information of China (English)

    JU Li-li

    2014-01-01

    There are eight types of English word formation, which are widely used nowadays in English. Among them, Borrowings, as one of widely used types of English word formation, has drawn people's attention because many English words are borrowed from other languages, such as German, Latin. This article aims to demonstrate Chinese Borrowings in English from two aspects.

  13. 77 FR 25168 - Appraisal Subcommittee (ASC); ASC Rules of Operation; Amended

    Science.gov (United States)

    2012-04-27

    ... Federal Housing Finance Agency. The ASC Rules of Operation serve as corporate bylaws outlining the ASC's... amended numerous provisions in Title XI. The ASC Rules of Operation serve as corporate bylaws outlining...

  14. Ambulatory Surgical Center (ASC) Payment System

    Data.gov (United States)

    U.S. Department of Health & Human Services — This file contains a summary of service utilization by ASC supplier and is derived from 2011 ASC line item level data, updated through June 2012, that is, line...

  15. Ambulatory Surgical Center (ASC) Payment System

    Data.gov (United States)

    U.S. Department of Health & Human Services — This file contains a summary of service utilization by ASC supplier and is derived from 2011 ASC line item level data, updated through June 2012, that is, line items...

  16. A Splice Variant of ASC Regulates IL-1β Release and Aggregates Differently from Intact ASC

    Directory of Open Access Journals (Sweden)

    Kazuhiko Matsushita

    2009-01-01

    Full Text Available The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD and caspase recruit domain (CARD, respectively, and exon 2 encodes a proline and glycine-rich (PGR domain. Here, we identified a variant ASC protein (vASC lacking the PGR domain that was smaller than full length ASC (fASC derived from fully transcribed mRNA and searched for differences in biochemical and biological nature. Both fASC and vASC were found to activate procaspase-1 to a similar degree, but the efficiency of IL-1β excretion was significantly higher for vASC. There was also a marked structural difference observed in the fibrous aggregates formed by fASC and vASC. These results suggest that although the PGR domain is dispensable for procaspase-1 activation, it plays an important role in the regulation of the molecular structure and activity of ASC.

  17. ASC-PROBA Interface Control Document

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Finn E;

    1999-01-01

    This document describes the Advanced Stellar Compass (ASC) and defines the interfaces between the instrument and the PROBA satellite. The ASC is a highly advanced and autonomous Stellar Reference Unit designed, developed and produced by the Space Instrumentation Group of the Department of Automat...

  18. 7 CFR 1789.153 - Borrower funding.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Borrower funding. 1789.153 Section 1789.153... Consultant Services Funded by Borrowers-General § 1789.153 Borrower funding. Borrowers shall use their general funds for the purposes of funding consultant services hereunder. Borrowers may not use...

  19. Linguistic Borrowing in Chicano Literature.

    Science.gov (United States)

    Chavez, Eliverio

    1989-01-01

    A preliminary investigation was conducted to determine the extent of linguistic borrowing in Chicano literature. The findings indicate the use of loanwords, loanblends, and loanshifts, but no examples of hybrid creation and grammatical borrowing. The use of loans correlates with characters marked by negative social qualities, which expresses a…

  20. Borrowing brainpower - sharing insecurities

    DEFF Research Database (Denmark)

    Wegener, Charlotte; Meier, Ninna; Ingerslev, Karen

    2016-01-01

    Academic writing is a vital, yet complex skill that must be developed within a doctoral training process. In addition, becoming an academic researcher is a journey of changing sense of self and identity. Through analysis of a group session, we show how the feedback of peers addresses questions...... of structure and writing style along with wider issues of researcher identity. Thus, peer learning is demonstrated as a process of simultaneously building a text and an identity as scholarly researcher. The paper advocates ‘borrowing brainpower’ from peers in order to write better texts and, at the same time......, ‘share insecurities’ during the development of the researcher identity. Based on a distributed notion of peer learning and identity, we point to the need for further research into the everyday activities of doctoral writing groups in order to understand the dynamic relationship between production of text...

  1. Evaluation of replacement protocols and modifications to TCP to enhance ASC Wide Area Network performance.

    Energy Technology Data Exchange (ETDEWEB)

    Romero, Randy L. Jr.

    2004-09-01

    Historically, TCP/IP has been the protocol suite used to transfer data throughout the Advanced Simulation and Computing (ASC) community. However, TCP was developed many years ago for an environment very different from the ASC Wide Area Network (WAN) of today. There have been numerous publications that hint of better performance if modifications were made to the TCP algorithms or a different protocol was used to transfer data across a high bandwidth, high delay WAN. Since Sandia National Laboratories wants to maximize the ASC WAN performance to support the Thor's Hammer supercomputer, there is strong interest in evaluating modifications to the TCP protocol and in evaluating alternatives to TCP, such as SCTP, to determine if they provide improved performance. Therefore, the goal of this project is to test, evaluate, compare, and report protocol technologies that enhance the performance of the ASC WAN.

  2. 75 FR 80813 - Appraisal Subcommittee (ASC); ASC Rules of Operation; Amended

    Science.gov (United States)

    2010-12-23

    ... and Urban Development. (See section 1.02 (4)). Section 3.02. General Powers. The affairs, business and... ASC's powers shall include those set forth in section 1106 of Title XI (12 U.S.C. 3335). The..., ] disapprove or veto. The matter shall be approved or disapproved by a majority vote of the ASC members...

  3. ASC-ATDM Performance Portability Requirements for 2015-2019

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Harold C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Computing Research Center; Trott, Christian Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Computing Research Center

    2015-03-01

    This report outlines the research, development, and support requirements for the Advanced Simulation and Computing (ASC ) Advanced Technology, Development, and Mitigation (ATDM) Performance Portability (a.k.a., Kokkos) project for 2015 - 2019 . The research and development (R&D) goal for Kokkos (v2) has been to create and demonstrate a thread - parallel programming model a nd standard C++ library - based implementation that enables performance portability across diverse manycore architectures such as multicore CPU, Intel Xeon Phi, and NVIDIA Kepler GPU. This R&D goal has been achieved for algorithms that use data parallel pat terns including parallel - for, parallel - reduce, and parallel - scan. Current R&D is focusing on hierarchical parallel patterns such as a directed acyclic graph (DAG) of asynchronous tasks where each task contain s nested data parallel algorithms. This five y ear plan includes R&D required to f ully and performance portably exploit thread parallelism across current and anticipated next generation platforms (NGP). The Kokkos library is being evaluated by many projects exploring algorithm s and code design for NGP. Some production libraries and applications such as Trilinos and LAMMPS have already committed to Kokkos as their foundation for manycore parallelism an d performance portability. These five year requirements includes support required for current and antic ipated ASC projects to be effective and productive in their use of Kokkos on NGP. The greatest risk to the success of Kokkos and ASC projects relying upon Kokkos is a lack of staffing resources to support Kokkos to the degree needed by these ASC projects. This support includes up - to - date tutorials, documentation, multi - platform (hardware and software stack) testing, minor feature enhancements, thread - scalable algorithm consulting, and managing collaborative R&D.

  4. Construction of library self-service borrowing and returning book system based on RFID technology%基于RFID技术的图书馆自助借还书系统建设研究

    Institute of Scientific and Technical Information of China (English)

    张永新; 靳玲

    2015-01-01

    按照“全军一个馆”总目标和提升图书管理借阅服务水平要求,提出了一种新的图书盘点方法;采用基于RFID技术的硬件设备和软件系统,构建了图书馆自助借还书系统。该系统有效解决了图书盘点效率和保密要求之间的矛盾,建成后的系统稳定性好、使用方便,大大提升了图书流通效率和图书管理水平。%According to the general objective for‘one library in the army wide’and the demand of enhancing the book management and service level of borrowing, this article proposes a new method for making an inventory of books, which employs the hardware equipment and software system based on RFID technology to construct a system of library self-service borrowing and returning book. This system can overcome effectively the contradiction between the book inventory efficiency and security demand, and the constructed system is of good system stability and easy to use, thus greatly boost the efficiency of book circulation and level of book ma na ge me nt.

  5. 7 CFR 1730.22 - Borrower analysis.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Borrower analysis. 1730.22 Section 1730.22... Borrower analysis. (a) Each borrower shall periodically analyze and document its security, operations and... any, the borrower's written analysis would also include a review of the operator's performance...

  6. The AscSimulationMode command

    DEFF Research Database (Denmark)

    Jørgensen, John Leif

    1998-01-01

    Complex instruments like the ASC may be quite difficult to test in closed loops. This problem is augmented by the fact, that no direct stimulation of the CHU is possible that will render the full performance, noise-spectrum and real-timeliness with high fidelity. In order to circumvent this impasse...

  7. The Phonological Assimilation of Borrowing.

    Science.gov (United States)

    Suleiman, Saleh M.

    Linguistic borrowing from English to Jordanian Arabic at the lexical level is described, focusing on phonology and the extent to which Jordanian Arabic has affected the phonetic structure of English loans assimilated partially or completely into it. Conspicuous distinctive sound features in the two languages that may affect non-native speakers'…

  8. ASC Trilab L2 Codesign Milestone 2015

    Energy Technology Data Exchange (ETDEWEB)

    Trott, Christian Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hammond, Simon David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dinge, Dennis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Edwards, Harold C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rajan, Mahesh [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    For the FY15 ASC L2 Trilab Codesign milestone Sandia National Laboratories performed two main studies. The first study investigated three topics (performance, cross-platform portability and programmer productivity) when using OpenMP directives and the RAJA and Kokkos programming models available from LLNL and SNL respectively. The focus of this first study was the LULESH mini-application developed and maintained by LLNL. In the coming sections of the report the reader will find performance comparisons (and a demonstration of portability) for a variety of mini-application implementations produced during this study with varying levels of optimization. Of note is that the implementations utilized including optimizations across a number of programming models to help ensure claims that Kokkos can provide native-class application performance are valid. The second study performed during FY15 is a performance assessment of the MiniAero mini-application developed by Sandia. This mini-application was developed by the SIERRA Thermal-Fluid team at Sandia for the purposes of learning the Kokkos programming model and so is available in only a single implementation. For this report we studied its performance and scaling on a number of machines with the intent of providing insight into potential performance issues that may be experienced when similar algorithms are deployed on the forthcoming Trinity ASC ATS platform.

  9. Does structural-typological similarity affect borrowability?: A quantitative study on affix borrowing

    NARCIS (Netherlands)

    F. Seifart

    2015-01-01

    This study addresses the question whether the borrowability of linguistic forms, in particular affixes, is constrained by structural properties of the donor and recipient languages involved. According to some claims, structural similarity favors affix borrowing. On some accounts, structural compatib

  10. Does structural-typological similarity affect borrowability?: A quantitative study on affix borrowing

    NARCIS (Netherlands)

    F. Seifart

    2014-01-01

    This study addresses the question whether the borrowability of linguistic forms, in particular affixes, is constrained by structural properties of the donor and recipient languages involved. According to some claims, structural similarity favors affix borrowing. On some accounts, structural compatib

  11. 7 CFR 4279.108 - Eligible borrowers.

    Science.gov (United States)

    2010-01-01

    ... services, or other activities that will: (1) Provide employment; (2) Improve the economic or environmental... anaerobic digesters for the purpose of energy generation). (b) Citizenship. Individual borrowers must...

  12. Behaviour of the disease resistance gene Asc in protoplasts of Lycopersicon esculentum mill

    NARCIS (Netherlands)

    Moussatos, V.; Witsenboer, H.; Hille, J.; Gilchrist, D.

    1993-01-01

    Action of Asc, a single dominant Mendelian gene controlling disease response at the whole plant level, was detected at the level of individual cells. Protoplasts, freshly isolated from resistant (Asc/Asc) and susceptible (asc/asc) tomato isolines, were differentially sensitive to AAL toxin as observ

  13. 34 CFR 682.604 - Processing the borrower's loan proceeds and counseling borrowers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Processing the borrower's loan proceeds and counseling...'s loan proceeds and counseling borrowers. (a) General. (1) This section establishes rules governing a school's processing of a borrower's Stafford or PLUS loan proceeds, and for counseling...

  14. 34 CFR 685.304 - Counseling borrowers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Counseling borrowers. 685.304 Section 685.304 Education... Direct Loan Program Schools § 685.304 Counseling borrowers. (a) Entrance counseling. (1) Except as provided in paragraph (a)(8) of this section, a school must ensure that entrance counseling is...

  15. 13 CFR 120.912 - Borrowed contributions.

    Science.gov (United States)

    2010-01-01

    ... borrow its cash contribution from the CDC or a third party. If any of the contribution is borrowed, the interest rate must be reasonable. If the loan is secured by any of the Project assets, the loan must be subordinate to the liens securing the 504 Loan, and the loan may not be repaid at a faster rate than the...

  16. Advanced Stirling Converter (ASC) Phase III Progress Update

    Science.gov (United States)

    Wood, J. Gary; Wilson, Kyle; Buffalino, Andrew; Frye, Patrick; Matejczyk, Dan; Penswick, L. B.

    2007-01-01

    Progress in the development of the Advanced Stirling Convertor (ASC) is presented here. The ASC is being developed under contact with the NASA Glenn Research Center and is supported by the Science Mission Directorate for potential use in future radioisotope power systems having significantly increased efficiency and higher specific power compared to the current thermoelectric systems. Phase II of the effort successfully demonstrated very high conversion efficiency and also demonstrated the low mass capability of the ASC design. The non-hermetic ASC-1 converters demonstrated during Phase II employ superalloy heater heads designed for greater than 14 years life at 850 °C operation. Phase III, which is reported on here, includes the fabrication of multiple next generation hermetic ASC-2 units. Phase III also includes the development of multiple lower-temperature (650 °C hot end) convertors based on the basic ASC design and designated as ASC-0 units. Multiple converters are being built for extended life testing at NASA GRC.

  17. USDA-ASCS 1936-1939 Air Photos

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data set is a digital version of aerial photographs taken during the 1936-1939 time frame for the USDA-ASCS. These photos were originally recorded at a scale of...

  18. Artificial Loading of ASC Specks with Cytosolic Antigens.

    Directory of Open Access Journals (Sweden)

    Ali Can Sahillioğlu

    Full Text Available Inflammasome complexes form upon interaction of Nod Like Receptor (NLR proteins with pathogen associated molecular patterns (PAPMS inside the cytosol. Stimulation of a subset of inflammasome receptors including NLRP3, NLRC4 and AIM2 triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck. The ASC speck is thought to be the platform of inflammasome activity, but the reason why a supramolecular complex is preferred against oligomeric platforms remains elusive. We observed that a set of cytosolic proteins, including the model antigen ovalbumin, tend to co-aggregate on the ASC speck. We suggest that co-aggregation of antigenic proteins on the ASC speck during intracellular infection might be instrumental in antigen presentation.

  19. Aquaculture Stewardship Council (ASC) ontwikkeltraject meerval : een inventarisatie

    NARCIS (Netherlands)

    Poelman, M.; Rothuis, A.J.; Bosma, R.H.

    2012-01-01

    Om een Aquaculture Stewardship Council (ASC) gecertificeerd product te krijgen is een standaard nodig, waaraan getoetst kan worden. Deze standaard geeft certificeerders een referentiekader. Pas als een standaard aanwezig is, kunnen producten gecertificeerd worden.

  20. The Astrobiology in Secondary Classrooms (ASC) curriculum: focusing upon diverse students and teachers.

    Science.gov (United States)

    Arino de la Rubia, Leigh S

    2012-09-01

    The Minority Institution Astrobiology Collaborative (MIAC) began working with the NASA Goddard Center for Astrobiology in 2003 to develop curriculum materials for high school chemistry and Earth science classes based on astrobiology concepts. The Astrobiology in Secondary Classrooms (ASC) modules emphasize interdisciplinary connections in astronomy, biology, chemistry, geoscience, physics, mathematics, and ethics through hands-on activities that address national educational standards. Field-testing of the Astrobiology in Secondary Classrooms materials occurred over three years in eight U.S. locations, each with populations that are underrepresented in the career fields of science, technology, engineering, and mathematics. Analysis of the educational research upon the high school students participating in the ASC project showed statistically significant increases in students' perceived knowledge and science reasoning. The curriculum is in its final stages, preparing for review to become a NASA educational product.

  1. Role of local borrowing in Croatia

    Directory of Open Access Journals (Sweden)

    Saša Drezgić

    2005-06-01

    Full Text Available Local government borrowing is one of the most important instruments of financing local public investments. Although theoretical findings and practical experiences provide a proof of its efficiency, there are reasons to be cautious. It is about the possibility of local public government fiscal activity to jeopardise macroeconomic stability, especially by excessive deficit financing. Therefore, there is a need for regulative constraint. The paper deals with international experience and tries to draw some applicable conclusions for Croatian regulation of local borrowing. Local borrowing in Croatia has been seriously limited and its potentials are underutilised. Constraints were imposed primarily because of the fiscal consolidation goals. However, there is still room for the local borrowing and for exploiting its advantages. The Paper offers some proposals.

  2. Environment - Borrow Area for Temporary Levee

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — This data represents the location of a borrow site for construction materials used in temporary levee building during flood events. The footprint of these areas have...

  3. CRSMP Potential Offshore Borrow Sites 2012

    Data.gov (United States)

    California Department of Resources — Offshore borrow sites as identified originally in the California Shoreline Database compiled by Noble Consultants (Jon Moore). Later updates to the dataset by the...

  4. CRSMP Potential Offshore Borrow Sites 2012

    Data.gov (United States)

    California Department of Resources — Offshore borrow sites as identified originally in the California Shoreline Database compiled by Noble Consultants (Jon Moore). Later updates to the dataset by the...

  5. Local government borrowing practice in Croatia

    Directory of Open Access Journals (Sweden)

    Anto Bajo

    2010-12-01

    Full Text Available The purpose of this paper is to analyze local government units’ borrowing in Croatia. Throughout the paper, we present the financial positions of local government units according to the size and structure of their gross and net debts, analyze borrowing conditions with commercial banks and the state development bank and discuss potential opportunities for and constraints on the issue of municipal bonds. Croatian local government units are not overindebted but do use guarantees to avoid central government borrowing restrictions.Sources of potential financial instability and risks to the creditworthiness of local government units can be found in the financial operations of utility companies. Inaugurating a credit rating system would improve control of adherence to budgetary constraints and determination of priorities for approving local government units’ borrowing.

  6. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan : ASC software quality engineering practices Version 3.0.

    Energy Technology Data Exchange (ETDEWEB)

    Turgeon, Jennifer L.; Minana, Molly A.; Hackney, Patricia; Pilch, Martin M.

    2009-01-01

    The purpose of the Sandia National Laboratories (SNL) Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. Quality is defined in the US Department of Energy/National Nuclear Security Agency (DOE/NNSA) Quality Criteria, Revision 10 (QC-1) as 'conformance to customer requirements and expectations'. This quality plan defines the SNL ASC Program software quality engineering (SQE) practices and provides a mapping of these practices to the SNL Corporate Process Requirement (CPR) 001.3.6; 'Corporate Software Engineering Excellence'. This plan also identifies ASC management's and the software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals. This SNL ASC Software Quality Plan establishes the signatories commitments to improving software products by applying cost-effective SQE practices. This plan enumerates the SQE practices that comprise the development of SNL ASC's software products and explains the project teams opportunities for tailoring and implementing the practices.

  7. Cultivating Borrowed Futures: The Politics of Neoliberal Loanwords in South Korean Cross-National Policy Borrowing

    Science.gov (United States)

    Sung, Youl-Kwan

    2011-01-01

    This paper examines the politics of policy-borrowing in Korean education. I use the term "loanwords" as a metaphor for the practice in some Korean educational sectors of using borrowed English-origin educational rhetoric to create actual policy reform. I argue that discourses of choice and diversity, as loanwords, are initially bifurcated into…

  8. Engineering a bilayered hydrogel to control ASC differentiation.

    Science.gov (United States)

    Natesan, Shanmugasundaram; Zamora, David O; Suggs, Laura J; Christy, Robert J

    2012-05-25

    Natural polymers over the years have gained more importance because of their host biocompatibility and ability to interact with cells in vitro and in vivo. An area of research that holds promise in regenerative medicine is the combinatorial use of novel biomaterials and stem cells. A fundamental strategy in the field of tissue engineering is the use of three-dimensional scaffold (e.g., decellularized extracellular matrix, hydrogels, micro/nano particles) for directing cell function. This technology has evolved from the discovery that cells need a substrate upon which they can adhere, proliferate, and express their differentiated cellular phenotype and function. More recently, it has also been determined that cells not only use these substrates for adherence, but also interact and take cues from the matrix substrate (e.g., extracellular matrix, ECM). Therefore, the cells and scaffolds have a reciprocal connection that serves to control tissue development, organization, and ultimate function. Adipose-derived stem cells (ASCs) are mesenchymal, non-hematopoetic stem cells present in adipose tissue that can exhibit multi-lineage differentiation and serve as a readily available source of cells (i.e. pre-vascular endothelia and pericytes). Our hypothesis is that adipose-derived stem cells can be directed toward differing phenotypes simultaneously by simply co-culturing them in bilayered matrices. Our laboratory is focused on dermal wound healing. To this end, we created a single composite matrix from the natural biomaterials, fibrin, collagen, and chitosan that can mimic the characteristics and functions of a dermal-specific wound healing ECM environment.

  9. Area C borrow Site Habitat Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sackschewsky, Michael R.; Downs, Janelle L.

    2009-12-04

    A habitat quality assessment was performed within selected portions of the proposed Area C Borrow Source. The previously identified Bitterbrush / Indian ricegrass stabilized dune element occurrence was determined to be better described as a sagebrush /needle-and-thread grass element occurrence of fair to good quality. A new habitat polygon is suggested adjacent to this element occurrence, which would also be sagebrush/needle-and-thread grass, but of poor quality. The proposed site of initial borrow site development was found to be a very low quality community dominated by cheatgrass.

  10. Area C borrow Site Habitat Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sackschewsky, Michael R.; Downs, Janelle L.

    2009-12-04

    A habitat quality assessment was performed within selected portions of the proposed Area C Borrow Source. The previously identified Bitterbrush / Indian ricegrass stabilized dune element occurrence was determined to be better described as a sagebrush /needle-and-thread grass element occurrence of fair to good quality. A new habitat polygon is suggested adjacent to this element occurrence, which would also be sagebrush/needle-and-thread grass, but of poor quality. The proposed site of initial borrow site development was found to be a very low quality community dominated by cheatgrass.

  11. Overview of ASC Capability Computing System Governance Model

    Energy Technology Data Exchange (ETDEWEB)

    Doebling, Scott W. [Los Alamos National Laboratory

    2012-07-11

    This document contains a description of the Advanced Simulation and Computing Program's Capability Computing System Governance Model. Objectives of the Governance Model are to ensure that the capability system resources are allocated on a priority-driven basis according to the Program requirements; and to utilize ASC Capability Systems for the large capability jobs for which they were designed and procured.

  12. Evaluating the Performance of Albanian Savings and Credit (ASC Union

    Directory of Open Access Journals (Sweden)

    Jonida Bou Dib (Lekocaj

    2013-04-01

    Full Text Available This research paper aimed to evaluate the role of ASC Union through three main poles:its performance in relation to outreach, its financial sustainability, and its welfare impact.It was based mainly on a descriptive study and focused on an accurate event, trying toanswer questions such as: what, where, how, who and when, through the use of differentinformation and already existing theories. Moreover, a triangulated methodologycombining interviews, questionnaires and observations was applied in order to analyze themicrocredit impacts.From the outreach angle, it was found that ASC Union's outreach has shown anincrement over the period of study with different rates of growth from 2003 to 2010 onaverage by 14.7%. On the other hand, the operational sustainability measured by returnon assets and return on equity showed instability over the period of the study, making theASC Union financial sustainability doubtful. In summary, the members confirmed thatASC Union helped them to improve their activities and income, where 87 out of 100farmers confirmed that their income increased in the last 3 years, while 31 farmers out of100, respectively 8, 9 and 10 year-old-members, proclaimed that using the micro-loanhelped them to expand their activities, while 56 farmers confirmed that microcredithelped them not only in improving their income and activity, but also their productionincrement and activity expansion.

  13. 42 CFR 416.164 - Scope of ASC services.

    Science.gov (United States)

    2010-10-01

    ... surgical procedure under § 416.166 include, but are not limited to— (1) Nursing, technician, and related... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM AMBULATORY SURGICAL SERVICES Coverage, Scope of ASC Services, and...

  14. The Borrowers: Issues in Using Previously Composed Text.

    Science.gov (United States)

    Begoray, Deborah L.

    1996-01-01

    Offers observations about the borrowing of written texts within a corporation called Cerebellum Inc. Attempts by doing so to initiate a dialog about the culturally constructed concept of plagiarism and the practice of borrowing from other people's work. (TB)

  15. 34 CFR 682.201 - Eligible borrowers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Eligible borrowers. 682.201 Section 682.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General Provisions § 682.201...

  16. New Directions in Policy Borrowing Research

    Science.gov (United States)

    Steiner-Khamsi, Gita

    2016-01-01

    Research on policy borrowing is a well-established research area of comparative education. Over the past 20 years or so it gained prominence among globalization scholars. Of great interest is not so much the question of which reforms "travel" internationally, and which ones are homebound, but rather why traveling reforms resonate in a…

  17. 5 CFR 4101.104 - Prohibited borrowing.

    Science.gov (United States)

    2010-01-01

    ... shall submit to his or her immediate supervisor, the ethics liaison in his or her office, and the DAEO... 4101.104 Administrative Personnel FARM CREDIT ADMINISTRATION SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE FARM CREDIT ADMINISTRATION § 4101.104 Prohibited borrowing. (a) Prohibition...

  18. 7 CFR 1773.4 - Borrower responsibilities.

    Science.gov (United States)

    2010-01-01

    ... in § 1773.21. (1) An annual auditor's report, report on compliance and on internal control over... the findings and recommendations in the auditor's report, report on compliance and on internal control.... (f) Submission of auditor's report. The borrower must submit to RUS the required auditor's...

  19. Borrowing constraints, multiple equilibria and monetary policy

    NARCIS (Netherlands)

    Assenza, T.

    2007-01-01

    The appealing feature of Kiyotaki and Moore's Financial Accelerator model (Kiyotaki and Moore, 1997, 2002) is the linkage of asset price changes and borrowing constraints. This framework therefore is the natural vehicle to explore the net worth channel of the monetary transmission mechanism. In the

  20. Borrowing constraints, multiple equilibria and monetary policy

    NARCIS (Netherlands)

    Assenza, T.

    2007-01-01

    The appealing feature of Kiyotaki and Moore's Financial Accelerator model (Kiyotaki and Moore, 1997, 2002) is the linkage of asset price changes and borrowing constraints. This framework therefore is the natural vehicle to explore the net worth channel of the monetary transmission mechanism. In the

  1. 7 CFR 761.102 - Borrower recordkeeping, reporting, and supervision.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Borrower recordkeeping, reporting, and supervision. 761.102 Section 761.102 Agriculture Regulations of the Department of Agriculture (Continued) FARM... Credit § 761.102 Borrower recordkeeping, reporting, and supervision. (a) A borrower must...

  2. 12 CFR 615.5250 - Disclosure requirements for borrower stock.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Disclosure requirements for borrower stock. 615.5250 Section 615.5250 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND... Disclosure requirements for borrower stock. (a) For sales of borrower stock, which for this subpart...

  3. Reciprocal Borrowing Patterns in the North Suburban Library System.

    Science.gov (United States)

    Able Consultants, DeKalb, IL.

    During a 5-day period in 1990, a total of 1,401 reciprocal borrowers in the North Suburban Library System (NSLS) received questionnaires asking about their choice of library and other aspects of borrowing behavior to provide data on the reciprocal borrowing characteristics and patterns within the system. This survey was designed to identify the…

  4. 76 FR 27668 - ASC Machine Tools, Inc., Spokane Valley, WA; Notice of Negative Determination on Reconsideration

    Science.gov (United States)

    2011-05-12

    ... Employment and Training Administration ASC Machine Tools, Inc., Spokane Valley, WA; Notice of Negative... Regarding Application for Reconsideration for the workers and former workers of ASC Machine Tools, Inc... adjustment assistance for workers and former workers of ASC Machine Tools, Inc., Spokane Valley,...

  5. Recognition of English and German Borrowings in the Russian Language (Based on Lexical Borrowings in the Field of Economics)

    Science.gov (United States)

    Ashrapova, Alsu; Alendeeva, Svetlana

    2014-01-01

    This article is the result of a study of the influence of English and German on the Russian language during the English learning based on lexical borrowings in the field of economics. This paper discusses the use and recognition of borrowings from the English and German languages by Russian native speakers. The use of lexical borrowings from…

  6. Solidification of Spent Ion Exchange Resin Using ASC Cement

    Institute of Scientific and Technical Information of China (English)

    周耀中; 云桂春; 叶裕才

    2002-01-01

    Ion exchange resins (IERs) have been widely used in nuclear facilities. However, the spent radioactive IERs result in major quantities of low and intermediate level radioactive wastes. This article describes a laboratory experimental study on solidification processing of IERs using a new type of cement named ASC cement. The strength of the cementation matrix is in the range of 18-20 MPa (28 d); the loading of the spent IER in the cement-resin matrix is over 45% and leaching rates of 137Cs, 90Sr and 60Co are 7.92×10-5, 5.7×10-6, and 1.19×10-8 cm/d. The results show that ASC cement can be a preferable cementation material for immobilization of radioactive spent IER.

  7. Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan. Part 2, Mappings for the ASC software quality engineering practices. Version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Molly A.; Heaphy, Robert; Sturtevant, Judith E.; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Forsythe, Christi A.; Schofield, Joseph Richard, Jr.; Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2005-01-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR 1.3.2 and 1.3.6 and to a Department of Energy document, 'ASCI Software Quality Engineering: Goals, Principles, and Guidelines'. This document also identifies ASC management and software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  8. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1: ASC software quality engineering practices, Version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Minana, Molly A.; Hackney, Patricia; Forsythe, Christi A.; Schofield, Joseph Richard, Jr. (,; .); Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR 1.3.2 and 1.3.6 and to a Department of Energy document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines. This document also identifies ASC management and software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  9. Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan. Part 2, Mappings for the ASC software quality engineering practices. Version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Molly A.; Heaphy, Robert; Sturtevant, Judith E.; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Forsythe, Christi A.; Schofield, Joseph Richard, Jr.; Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2005-01-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR 1.3.2 and 1.3.6 and to a Department of Energy document, 'ASCI Software Quality Engineering: Goals, Principles, and Guidelines'. This document also identifies ASC management and software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  10. Sandia National Laboratories Advanced Simulation and Computing (ASC) : appraisal method for the implementation of the ASC software quality engineering practices: Version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Turgeon, Jennifer; Minana, Molly A.

    2008-02-01

    This document provides a guide to the process of conducting software appraisals under the Sandia National Laboratories (SNL) ASC Program. The goal of this document is to describe a common methodology for planning, conducting, and reporting results of software appraisals thereby enabling: development of an objective baseline on implementation of the software quality engineering (SQE) practices identified in the ASC Software Quality Plan across the ASC Program; feedback from project teams on SQE opportunities for improvement; identification of strengths and opportunities for improvement for individual project teams; guidance to the ASC Program on the focus of future SQE activities Document contents include process descriptions, templates to promote consistent conduct of appraisals, and an explanation of the relationship of this procedure to the SNL ASC software program.

  11. Studying borrower level risk characteristics of education loan in India

    Directory of Open Access Journals (Sweden)

    Arindam Bandyopadhyay

    2016-09-01

    Full Text Available This paper empirically investigates the granular level risk of education loan using a cross section of data from 5000 borrowers obtained from four major public sector banks in India. The findings suggest that education loan defaults are mainly influenced by security, borrower margin, and repayment periods. The presence of guarantor or co-borrower and collateral significantly reduce default loss rates. The socioeconomic characteristics of borrowers and their regional locations also act as important factors associated with education loan defaults. The results suggest that by segmenting borrowers by probability of default and loss given default in a multidimensional scale, banks can adopt better risk mitigation and pricing strategies to resolve borrower problems.

  12. Finance Companies and Small Business Borrowers: An Empirical Investigation

    OpenAIRE

    Haynes, George; Watts, Myles

    1996-01-01

    Finance companies have been perceived as isolated and insignificant lenders, attracting high risk borrowers and charging these borrowers relatively high prices. Using the 1988 National Survey of Small Business Finance, this study examines the relationship between finance companies and other lenders, describes the characteristics of borrowers attracted to finance companies and assesses whether finance companies charge higher loan prices and impose more stringent collateral requirements on thei...

  13. CRSMP Potential Coastal and Upland Borrow Sites 2012

    Data.gov (United States)

    California Department of Resources — Upland debris basins and coastal borrow sites as identified originally in the California Shoreline Database compiled by Noble Consultants (Jon Moore). Later updates...

  14. Comparison of Effects of Mechanical Stretching on Osteogenic Potential of ASCs and BMSCs

    Institute of Scientific and Technical Information of China (English)

    Brian E. Grottkau; Xingmei Yang; Liang Zhang; Ling Ye; Yunfeng Lin

    2013-01-01

    Mechanical forces play critical roles in the development and remodeling processes of bone. As an alternative cell source for bone engineering, adipose-derived stem cells (ASCs) should be fully investigated for their responses to mechanical stress. Similarly, the osteogenic potential, stimulated by mechanical stress, should be compared with bone marrow stromal cells (BMSCs), which have been clinically used for bone tissue engineering. In this study, ASCs and BMSCs were osteogenic-induced for 48 hours, and then subjected to uniaxial mechanical stretching for 2 or 6 hours. Cell orientation, osteogenic regulatory genes, osteogenic genes and ALP activities were measured and compared between ASCs and BMSCs. ASCs could align in a perpendicular way to the direction of stretching stress, while BMSCs did not present a specific alignment. Both 2 and 6 hours mechanical stretching could enhance the mRNA expression of Osx and Runx2 in BMSCs and ASCs, while OCN mRNA only increased in ASCs after 6 hours mechanical loading. Mechanical stretching enhanced the BMP-2 mRNA expression in ASCs, while only after 6 hours of mechanical loading significantly increased the BMP-2 gene expression in BMSCs. Significant differences only exist between ASCs and BMSCs loaded at 2 hours of mechanical stretching. It is concluded that ASCs are more rapid responders to mechanical stress, and have greater potential than BMSCs in osteogenesis when stimulated by mechanical stretching, indicating their usefulness for bone study in a rat model.

  15. Environmental Loss Characterization of an Advanced Stirling Convertor (ASC-E2) Insulation Package Using a Mock Heater Head

    Science.gov (United States)

    Schifer, Nicholas A.; Briggs, Maxwell H.

    2012-01-01

    The U.S. Department of Energy (DOE) and Lockheed Martin Space Systems Company (LMSSC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. This generator would use two highefficiency Advanced Stirling Convertors (ASCs), developed by Sunpower Inc. and NASA Glenn Research Center (GRC). As part of ground testing of these ASCs, different operating conditions are used to simulate expected mission conditions. These conditions require achieving a specified electrical power output for a given net heat input. While electrical power output can be precisely quantified, thermal power input to the Stirling cycle cannot be directly measured. In an effort to improve net heat input predictions, the Mock Heater Head was developed with the same relative thermal paths as a convertor using a conducting rod to represent the Stirling cycle and tested to provide a direct comparison to numerical and empirical models used to predict convertor net heat input. The Mock Heater Head also served as the pathfinder for a higher fidelity version of validation test hardware, known as the Thermal Standard. This paper describes how the Mock Heater Head was tested and utilized to validate a process for the Thermal Standard.

  16. 7 CFR 1724.30 - Borrowers' requirements-engineering services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Borrowers' requirements-engineering services. 1724.30... PROCEDURES Engineering Services § 1724.30 Borrowers' requirements—engineering services. The provisions of... instruments pertaining to the engineering details required by RUS. (e) Additional requirements related...

  17. Lexical Borrowing from Chinese Languages in Malaysian English

    Science.gov (United States)

    Imm, Tan Siew

    2009-01-01

    This paper explores how contact between English and Chinese has resulted in the incorporation of Chinese borrowings into the lexicon of Malaysian English (ME). Using a corpus-based approach, this study analyses a comprehensive range of borrowed features extracted from the Malaysian English Newspaper Corpus (MEN Corpus). Based on the contexts of…

  18. 12 CFR 617.7010 - May borrower rights be waived?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false May borrower rights be waived? 617.7010 Section 617.7010 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS General § 617... to distressed loan restructuring, credit reviews, and the right of first refusal when a loan...

  19. 24 CFR 891.600 - Responsibilities of Borrower.

    Science.gov (United States)

    2010-04-01

    ... fair housing marketing plan and all Federal, State, or local fair housing and equal opportunity... Handicapped-Section 8 Assistance § 891.600 Responsibilities of Borrower. (a) Marketing. (1) The Borrower must commence and continue diligent marketing activities not later than 90 days before the anticipated date...

  20. Education Policy Borrowing and Cultural Scripts for Teaching in China

    Science.gov (United States)

    Tan, Charlene

    2015-01-01

    China's recent education reforms are a result of selective policy borrowing from "the West". Although comparativists have highlighted the importance of cultural context in policy borrowing in China, what remains relatively under-explored is the epistemological basis for cultural views that mediate policy transfer. This article argues…

  1. Lexical Borrowings in the ESL Classrooms in Malaysia

    Science.gov (United States)

    Thirusanku, Jantmary; Yunus, Melor Md

    2013-01-01

    This paper attempts to show the use of lexical borrowings in ten teaching materials used by the English as Second Language (ESL) teachers in the ESL classrooms in the National Secondary Schools in the Klang district in Selangor, Malaysia. It also discusses the general and pedagogical implications involved in using lexical borrowings. This paper…

  2. Sobre prestamos y clasificaciones linguisticas (Regarding Borrowing and Linguistic Classification).

    Science.gov (United States)

    Key, Mary Ritchie

    1988-01-01

    This article explores the traditionally accepted etymologies of several lexical borrowings in the indigenous languages of the Americas within the framework of comparative linguistics and linguistic classification. The first section presents a general discussion of the problem of tracing lexical borrowings in this context. The section features a…

  3. GRAMEEN BANK BORROWER VIABILITY: FINDINGS FROM FIELD SURVEYS

    OpenAIRE

    1989-01-01

    Bangladesh Bank and Mahabub Hossain survey of Grameen Bank borrowers is examined. It is observed that the borrowers have gained substantially in Income following the use of credit. Income gain, however, is not sufficient to repay credit under the stipulated terms.

  4. Compelling Untruths: Content Borrowing and Vivid False Memories

    Science.gov (United States)

    Lampinen, James Michael; Meier, Christopher R.; Arnal, Jack D.; Leding, Juliana K.

    2005-01-01

    False memories are sometimes accompanied by surprisingly vivid experiential detail that makes them difficult to distinguish from actual memories. Such strikingly real false memories may be produced by a process called content borrowing in which details from presented items are errantly borrowed to corroborate the occurrence of the false memory…

  5. 34 CFR 685.206 - Borrower responsibilities and defenses.

    Science.gov (United States)

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Borrower Provisions... eligible to receive assistance under title IV of the Act. (iii) Updating reports to credit bureaus to which the Secretary previously made adverse credit reports with regard to the borrower's Direct Loan....

  6. A Survey of Reciprocal Borrowers at Nichols Library, Naperville, Illinois.

    Science.gov (United States)

    Strack, Nancy C.

    This paper presents results of a survey that examined the spending activities of patrons from other libraries while in Naperville (Illinois) using their reciprocal borrowing privileges at Nichols Library, the local public library. Results of a questionnaire from 100 of the 7,540 registered reciprocal borrowers provide information on: home…

  7. An Analysis of Direct Reciprocal Borrowing among Quebec University Libraries

    Science.gov (United States)

    Duy, Joanna C.; Lariviere, Vincent

    2013-01-01

    An analysis of Quebec academic libraries' direct reciprocal borrowing statistics from 2005 to 2010 reveals that the physical distance separating universities plays an important role in determining the amount of direct reciprocal borrowing activity conducted between institutions. Significant statistical correlations were also seen between the…

  8. The semantics of English Borrowings in Arabic Media Language: The case of Arab Gulf States Newspapers

    Directory of Open Access Journals (Sweden)

    Anwar A. H. Al-Athwary

    2016-07-01

    Full Text Available The present paper investigates the semantics of English loanwords in Arabic media language (AML. The loanword data are collected from a number of Arab Gulf states newspapers (AGSNs. They  are analyzed semantically from the points of view of semantic change, semantic domains, and the phenomenon of synonymy resulting from lexical borrowing. The semantic analysis has revealed that AML borrowings from English occur in fifteen distinctive semantic domains. Domains that are related to terms of technical and scientific nature are found ranking much higher (9% - 18% than those domains containing nontechnical elements (1% - 8% with the computer and technology category (18% is the most dominant domain. Almost all common mechanisms of semantic change (extension, restriction, amelioration, pejoration, and metaphorical extension are found at work in the context of AML borrowings. The tendency of semantic change in the overwhelming majority of AML borrowings is towards restriction.  Factors like need, semantic similarity, and factors of social and psychological considerations (e.g. prestige, taboo seem to be the potent factors at interplay in semantic change. The first two, i.e. need and semantic similarity, are the most common reasons in most types of semantic change. The problem of synonymy lies in those loanwords that have “Arabic equivalents” in the language. The study claims that this phenomenon could be attributed to the two simultaneous processes of lexical borrowing and?ištiqa:q (the modern efforts of deriving equivalent neologisms.Keywords: loanwords, semantic change, semantic domains, synonymy, Arabic media language

  9. Visualization on supercomputing platform level II ASC milestone (3537-1B) results from Sandia.

    Energy Technology Data Exchange (ETDEWEB)

    Geveci, Berk (Kitware, Inc., Clifton Park, NY); Fabian, Nathan; Marion, Patrick (Kitware, Inc., Clifton Park, NY); Moreland, Kenneth D.

    2010-09-01

    This report provides documentation for the completion of the Sandia portion of the ASC Level II Visualization on the platform milestone. This ASC Level II milestone is a joint milestone between Sandia National Laboratories and Los Alamos National Laboratories. This milestone contains functionality required for performing visualization directly on a supercomputing platform, which is necessary for peta-scale visualization. Sandia's contribution concerns in-situ visualization, running a visualization in tandem with a solver. Visualization and analysis of petascale data is limited by several factors which must be addressed as ACES delivers the Cielo platform. Two primary difficulties are: (1) Performance of interactive rendering, which is most computationally intensive portion of the visualization process. For terascale platforms, commodity clusters with graphics processors(GPUs) have been used for interactive rendering. For petascale platforms, visualization and rendering may be able to run efficiently on the supercomputer platform itself. (2) I/O bandwidth, which limits how much information can be written to disk. If we simply analyze the sparse information that is saved to disk we miss the opportunity to analyze the rich information produced every timestep by the simulation. For the first issue, we are pursuing in-situ analysis, in which simulations are coupled directly with analysis libraries at runtime. This milestone will evaluate the visualization and rendering performance of current and next generation supercomputers in contrast to GPU-based visualization clusters, and evaluate the performance of common analysis libraries coupled with the simulation that analyze and write data to disk during a running simulation. This milestone will explore, evaluate and advance the maturity level of these technologies and their applicability to problems of interest to the ASC program. Scientific simulation on parallel supercomputers is traditionally performed in four

  10. Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.

    Science.gov (United States)

    Kim, Geun Hyang; Park, Keunhee; Yeom, Seon-Yong; Lee, Kyung Jin; Kim, Gukhan; Ko, Jesang; Rhee, Dong-Kwon; Kim, Young Hoon; Lee, Hye Kyung; Kim, Hae Won; Oh, Goo Taeg; Lee, Ki-Up; Lee, Jae W; Kim, Seung-Whan

    2009-07-01

    Activating signal cointegrator-2 (ASC-2) functions as a transcriptional coactivator of many nuclear receptors and also plays important roles in the physiology of the liver and pancreas by interacting with liver X receptors (LXRs), which antagonize the development of atherosclerosis. This study was undertaken to establish the specific function of ASC-2 in macrophages and atherogenesis. Intriguingly, ASC-2 was more highly expressed in macrophages than in the liver and pancreas. To inhibit LXR-specific activity of ASC-2, we used DN2, which contains the C-terminal LXXLL motif of ASC-2 and thereby acts as an LXR-specific, dominant-negative mutant of ASC-2. In DN2-overexpressing transgenic macrophages, cellular cholesterol content was higher and cholesterol efflux lower than in control macrophages. DN2 reduced LXR ligand-dependent increases in the levels of ABCA1, ABCG1, and apolipoprotein E (apoE) transcripts as well as the activity of luciferase reporters driven by the LXR response elements (LXREs) of ABCA1, ABCG1, and apoE genes. These inhibitory effects of DN2 were reversed by overexpression of ASC-2. Chromatin immunoprecipitation analysis demonstrated that ASC-2 was recruited to the LXREs of the ABCA1, ABCG1, and apoE genes in a ligand-dependent manner and that DN2 interfered with the recruitment of ASC-2 to these LXREs. Furthermore, low-density lipoprotein receptor (LDLR)-null mice receiving bone marrow transplantation from DN2-transgenic mice showed accelerated atherogenesis when administered a high-fat diet. Taken together, these results indicate that suppression of the LXR-specific activity of ASC-2 results in both defective cholesterol metabolism in macrophages and accelerated atherogenesis, suggesting that ASC-2 is an antiatherogenic coactivator of LXRs in macrophages.

  11. Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC

    Directory of Open Access Journals (Sweden)

    Sabine Stöckl

    2013-05-01

    Full Text Available Background: Mesenchymal stem cells (MSC are promising tools for tissue-engineering and musculoskeletal regeneration. They reside within various tissues, like adipose tissue, periosteum, synovia, muscle, dermis, blood and bone marrow, latter being the most common tissue used for MSC isolation. A promising alternative source for MSC is adipose tissue due to better availability and higher yield of MSC in comparison to bone marrow. A drawback is the yet fragmentary knowledge of adipose-derived stem cell (ASC physiology in order to make them a safe tool for in vivo application. Methods/Results: Here, we identified Sox9 as a highly expressed and crucial transcription factor in undifferentiated rat ASC (rASC. In comparison to rat bone marrow-derived stem cells (rBMSC, mRNA and protein levels of Sox9 were significantly higher in rASC. To study the role of Sox9 in detail, we silenced Sox9 with shRNA in rASC and examined proliferation, apoptosis and the expression of osteogenic differentiation markers. Our results clearly point to a difference in the expression profile of osteogenic marker genes between undifferentiated rASC and rBMSC in early passages. Sox9 silencing induced the expression of osteocalcin, Vegfα and Mmp13, and decreased rASC proliferation accompanied with an induction of p21 and cyclin D1 expression and delayed S-phase entry. Conclusions: We suggest a pro-proliferative role for Sox9 in undifferentiated rASC which may explain the higher proliferation rate of rASC compared to rBMSC. Moreover, we propose an osteogenic differentiation delaying role of Sox9 in rASC which suggests that Sox9 expression is needed to maintain rASC in an undifferentiated, proliferative state.

  12. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan part 2 mappings for the ASC software quality engineering practices, version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Heaphy, Robert; Sturtevant, Judith E.; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Minana, Molly A.; Hackney, Patricia; Forsythe, Christi A.; Schofield, Joseph Richard, Jr. (,; .); Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR001.3.2 and CPR001.3.6 and to a Department of Energy document, ''ASCI Software Quality Engineering: Goals, Principles, and Guidelines''. This document also identifies ASC management and software project teams' responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  13. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan part 2 mappings for the ASC software quality engineering practices, version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Heaphy, Robert; Sturtevant, Judith E.; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Minana, Molly A.; Hackney, Patricia; Forsythe, Christi A.; Schofield, Joseph Richard, Jr. (,; .); Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR001.3.2 and CPR001.3.6 and to a Department of Energy document, ''ASCI Software Quality Engineering: Goals, Principles, and Guidelines''. This document also identifies ASC management and software project teams' responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  14. The Future of Sovereign Borrowing in Europe

    DEFF Research Database (Denmark)

    the sovereign bonds of safe-haven countries have come under close scrutiny or lost some of their prime ratings. Yet crisis countries have seen dramatic downgrades of their sovereign debt ratings so that they face soaring risk spreads and unsustainably high financing costs (or even a loss of access to bond......In March 2013 around 130 participants from academia, banking and finance, governments and central banking gathered at the premises of the OeNB in Vienna for a conference jointly organized by the European Money and Finance Forum SUERF, the OeNB and the Austrian Society for Bank Research to discuss...... “The Future of Sovereign Borrowing.” The financial, economic and sovereign debt crisis has fundamentally changed the rules of the game in sovereign debt markets, particularly in the euro area, but also beyond its borders. Sovereign bonds are no longer widely perceived as ‘risk-free’ assets. Even...

  15. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1 : ASC software quality engineering practices version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Minana, Molly A.; Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Forsythe, Christi A.; Schofield, Joseph Richard, Jr.; Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2005-01-01

    The purpose of the Sandia National Laboratories (SNL) Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. Quality is defined in DOE/AL Quality Criteria (QC-1) as conformance to customer requirements and expectations. This quality plan defines the ASC program software quality practices and provides mappings of these practices to the SNL Corporate Process Requirements (CPR 1.3.2 and CPR 1.3.6) and the Department of Energy (DOE) document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines (GP&G). This quality plan identifies ASC management and software project teams' responsibilities for cost-effective software engineering quality practices. The SNL ASC Software Quality Plan establishes the signatories commitment to improving software products by applying cost-effective software engineering quality practices. This document explains the project teams opportunities for tailoring and implementing the practices; enumerates the practices that compose the development of SNL ASC's software products; and includes a sample assessment checklist that was developed based upon the practices in this document.

  16. Specification of the ASC to be used on the PRC satellite (HITSAT)

    DEFF Research Database (Denmark)

    Jørgensen, Finn E; Thuesen, Gøsta; Kilsgaard, Søren;

    1999-01-01

    The document describes the technical specifications of the ASC Star Tracker and the requirements for the equipment onboard the satellite HITSAT .......The document describes the technical specifications of the ASC Star Tracker and the requirements for the equipment onboard the satellite HITSAT ....

  17. 75 FR 65516 - ASC Machine Tools, Inc., Spokane Valley, WA; Notice of Affirmative Determination Regarding...

    Science.gov (United States)

    2010-10-25

    ... Employment and Training Administration ASC Machine Tools, Inc., Spokane Valley, WA; Notice of Affirmative... apply for Trade Adjustment Assistance (TAA) applicable to workers and former workers of ASC Machine Tools, Inc., Spokane Valley, Washington (the subject firm). The Notice of negative determination...

  18. Technology Maturity is Technology Superiority

    Science.gov (United States)

    2008-09-09

    Dominant Air Power: Design For Tomorrow…Deliver Today 2 TECHNOLOGY MATURITY CONFERENCE • ONE DEFINITION OF MATURITY – GOOD JUDGEMENT COMES FROM...EXPERIENCE—EXPERIENCE COMES FROM BAD JUDGEMENT Dominant Air Power: Design For Tomorrow…Deliver Today 3 TECHNOLOGY MATURITY CONFERENCE • THIS WILL BE A...2008 TECHNOLOGY MATURITY CONFERENCE “ TECHNOLOGY MATURITY IS TECHNOLOGY SUPERIORITY” Aeronautical Systems Center Dr. Tom Christian ASC/EN, WPAFB OH

  19. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC regulates inflammasomes

    Directory of Open Access Journals (Sweden)

    Rojanasakul Yon

    2010-05-01

    Full Text Available Abstract Background The apoptotic speck-like protein containing a caspase recruitment domain (ASC is the essential adaptor protein for caspase 1 mediated interleukin (IL-1β and IL-18 processing in inflammasomes. It bridges activated Nod like receptors (NLRs, which are a family of cytosolic pattern recognition receptors of the innate immune system, with caspase 1, resulting in caspase 1 activation and subsequent processing of caspase 1 substrates. Hence, macrophages from ASC deficient mice are impaired in their ability to produce bioactive IL-1β. Furthermore, we recently showed that ASC translocates from the nucleus to the cytosol in response to inflammatory stimulation in order to promote an inflammasome response, which triggers IL-1β processing and secretion. However, the precise regulation of inflammasomes at the level of ASC is still not completely understood. In this study we identified and characterized three novel ASC isoforms for their ability to function as an inflammasome adaptor. Methods To establish the ability of ASC and ASC isoforms as functional inflammasome adaptors, IL-1β processing and secretion was investigated by ELISA in inflammasome reconstitution assays, stable expression in THP-1 and J774A1 cells, and by restoring the lack of endogenous ASC in mouse RAW264.7 macrophages. In addition, the localization of ASC and ASC isoforms was determined by immunofluorescence staining. Results The three novel ASC isoforms, ASC-b, ASC-c and ASC-d display unique and distinct capabilities to each other and to full length ASC in respect to their function as an inflammasome adaptor, with one of the isoforms even showing an inhibitory effect. Consistently, only the activating isoforms of ASC, ASC and ASC-b, co-localized with NLRP3 and caspase 1, while the inhibitory isoform ASC-c, co-localized only with caspase 1, but not with NLRP3. ASC-d did not co-localize with NLRP3 or with caspase 1 and consistently lacked the ability to function as an

  20. Participatory Savings And Borrowing For Start-Up And ...

    African Journals Online (AJOL)

    Journal of Agriculture and Social Research (JASR) ... Participatory Savings And Borrowing For Start-Up And Recapitalization Needs: Farmers ... be considered for more loans whenever they meet up with the conditions for such new contracts.

  1. Medical Terminology Borrowed into Romanian from Latin through German

    Directory of Open Access Journals (Sweden)

    Rodica Teodora BIRIŞ

    2011-01-01

    Full Text Available In this article, I have researched the Latin borrowings in medicine that have entered the Romanian language through German. These borrowings constitute a complex image of the linguistic interferences from the lexical – semantic field.The Romanian language is a “hospitable” language, which easily assimilates borrowings from other languages, and one of its main features is the ease with which it absorbs Latin neologisms, especially at the end of the 18th and the beginning of the 19th centuries, when important sectors of literary Romanian’s vocabulary were enriched with Latin terms.In this article we focused our attention on the Latin borrowings in the field of medicine.

  2. 7 CFR 1724.20 - Borrowers' requirements-architectural services.

    Science.gov (United States)

    2010-01-01

    ... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN... source of financing. (a) Each borrower shall select a qualified architect to perform the architectural services required for the design and construction management of headquarters facilities. The selection...

  3. 12 CFR 220.103 - Borrowing of securities.

    Science.gov (United States)

    2010-01-01

    ... delivery of such securities in the case of short sales, failure to receive securities he is required to... occurred or is in immediate prospect. The provision does not authorize a broker to borrow securities...

  4. Composition-dependent structural changes and antitumor activity of ASC-DP/DSPE-PEG nanoparticles.

    Science.gov (United States)

    Higashi, Kenjirou; Mibu, Fusako; Saito, Kengo; Limwikrant, Waree; Yamamoto, Keiji; Moribe, Kunikazu

    2017-03-01

    Ascorbyl 2,6-dipalmitate (ASC-DP) and distearoyl phosphatidylethanolamine polyethylene glycol 2000 (DSPE-PEG) formed stable nanoparticles at a molar ratio of less than or equal to 2:1 after dispersing the solvent-evaporated film in water. The mean particle sizes measured by dynamic light scattering were within the range of ca. 100-160nm. Composition-dependent changes of the ASC-DP and DSPE-PEG molecular states within the film were analyzed by wide-angle X-ray diffraction and infrared (IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. Transmission electron microscopy (TEM) of nanoparticles revealed that ASC-DP/DSPE-PEG changed from a micelle to a disk and tubular structure as the molar ratio increased. Quantitative solution-state (1)H NMR measurements elucidated the structure of nanoparticle in water; the core could be composed of ASC-DP and hydrophobic acyl chains of DSPE, whereas the hydrophilic PEG chains of DSPE-PEG on the surface form the hydration shell to stabilize the nanoparticle dispersion in water. Cytotoxicity of ASC-DP against cancer cell lines was observed by using ASC-DP/DSPE-PEG nanoparticles, and no cytotoxicity against normal cells was found. Thus, the ASC-DP/DSPE-PEG formulation, with tumor cell specific cytotoxicity, can be applicable for cancer monotherapy or in combination with other anticancer drugs. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. ASC Predictive Science Academic Alliance Program Verification and Validation Whitepaper

    Energy Technology Data Exchange (ETDEWEB)

    Klein, R; Graziani, F; Trucano, T

    2006-03-31

    The purpose of this whitepaper is to provide a framework for understanding the role that verification and validation (V&V) are expected to play in successful ASC Predictive Science Academic Alliance (PSAA) Centers and projects. V&V have been emphasized in the recent specification of the PSAA (NNSA, 2006): (1) The resulting simulation models lend themselves to practical verification and validation methodologies and strategies that should include the integrated use of experimental and/or observational data as a key part of model and sub-model validation, as well as demonstrations of numerical convergence and accuracy for code verification. (2) Verification, validation and prediction methodologies and results must be much more strongly emphasized as research topics and demonstrated via the proposed simulations. (3) It is mandatory that proposals address the following two topics: (a) Predictability in science & engineering; and (b) Verification & validation strategies for large-scale simulations, including quantification of uncertainty and numerical convergence. We especially call attention to the explicit coupling of computational predictability and V&V in the third bullet above. In this whitepaper we emphasize this coupling, and provide concentrated guidance for addressing item 2. The whitepaper has two main components. First, we provide a brief and high-level tutorial on V&V that emphasizes critical elements of the program. Second, we state a set of V&V-related requirements that successful PSAA proposals must address.

  6. Testing the Nonce Borrowing Hypothesis: Counter-Evidence from English-Origin Verbs in Welsh

    Science.gov (United States)

    Stammers, Jonathan R.; Deuchar, Margaret

    2012-01-01

    According to the nonce borrowing hypothesis (NBH), "[n]once borrowings pattern exactly like their native counterparts in the (unmixed) recipient language" (Poplack & Meechan, 1998a, p. 137). Nonce borrowings (Sankoff, Poplack & Vanniarajan, 1990, p. 74) are "lone other-language items" which differ from established borrowings in terms of frequency…

  7. The English-Slovene language contact: borrowing of personal names

    Directory of Open Access Journals (Sweden)

    Eva Sicherl

    2015-12-01

    Full Text Available The article aims to shed some light on the growing tendency of Slovene native speakers towards borrowing English personal names when naming new-born children. Some historical overview of the borrowing of English personal names into Slovene is given, starting with lists compiled from 1931 onwards, established from the data supplied by the Statistical Office of the Republic of Slovenia (SURS. The phenomenon of borrowing personal names is discussed from the point of view of pragmatic borrowing as advocated by G. Andersen (2014, taking into account the traditional distinction between necessary loans on the one hand and luxury loans on the other. The article illustrates how in the case of personal names, ‘exoticisms’ (e.g. Alex, Liam, Kevin, Kim, Ian, Vanessa, Adrian, Ella, Emma, Patrick, Nick, Alan, Lucas, listed among the most popular 200 first names in the 2001–2013 period compete with name forms that have been adapted and nativised long ago (e.g. Patrik, or are currently being introduced for the first time into Slovene. In these recent borrowings, the foreign forms undergo some adaptation, but at the same time, unlike other anglicisms, show the tendency to resist complete adaptation, particularly in terms of spelling and pronunciation. Such pragmatically borrowed items carry significant sociolinguistic signals about the borrowers’ attitudes, and these are briefly commented on.

  8. Immunomagnetic Separation of Fat Depot-Specific Sca1high Adipose-Derived Stem Cells (Ascs)

    Science.gov (United States)

    Barnes, Richard H; Chun, Tae-Hwa

    2016-01-01

    The isolation of adipose-derived stem cells (ASCs) is an important method in the field of adipose tissue biology, adipogenesis, and extracellular matrix (ECM) remodeling. In vivo, ECM-rich environment consisting of fibrillar collagens provides a structural support to adipose tissues during the progression and regression of obesity. Physiological ECM remodeling mediated by matrix metalloproteinases (MMPs) plays a major role in regulating adipose tissue size and function1, 2. The loss of physiological collagenolytic ECM remodeling may lead to excessive collagen accumulation (tissue fibrosis), macrophage infiltration, and ultimately, a loss of metabolic homeostasis including insulin resistance3, 4. When a phenotypic change of the adipose tissue is observed in gene-targeted mouse models, isolating primary ASCs from fat depots for in vitro studies is an effective approach to define the role of the specific gene in regulating the function of ASCs. In the following, we define an immunomagnetic separation of Sca1high ASCs. PMID:27583550

  9. Methylation mediated silencing of TMS1/ASC gene in prostate cancer

    Directory of Open Access Journals (Sweden)

    Gopisetty Gopal

    2006-07-01

    Full Text Available Abstract Background Transcriptional silencing associated with aberrant promoter methylation has been established as an alternate pathway for the development of cancer by inactivating tumor suppressor genes. TMS1 (Target of Methylation induced Silencing, also known as ASC (Apoptosis Speck like protein containing a CARD is a tumor suppressor gene which encodes for a CARD (caspase recruitment domain containing regulatory protein and has been shown to promote apoptosis directly and by activation of downstream caspases. This study describes the methylation induced silencing of TMS1/ASC gene in prostate cancer cell lines. We also examined the prevalence of TMS1/ASC gene methylation in prostate cancer tissue samples in an effort to correlate race and clinico-pathological features with TMS1/ASC gene methylation. Results Loss of TMS1/ASC gene expression associated with complete methylation of the promoter region was observed in LNCaP cells. Gene expression was restored by a demethylating agent, 5-aza-2'deoxycytidine, but not by a histone deacetylase inhibitor, Trichostatin A. Chromatin Immunoprecipitation (ChIP assay showed enrichment of MBD3 (methyl binding domain protein 3 to a higher degree than commonly associated MBDs and MeCP2. We evaluated the methylation pattern in 66 prostate cancer and 34 benign prostatic hyperplasia tissue samples. TMS1/ASC gene methylation was more prevalent in prostate cancer cases than controls in White patients (OR 7.6, p 0.002 while no difference between the cases and controls was seen in Black patients (OR 1.1, p 0.91. Conclusion Our study demonstrates that methylation-mediated silencing of TMS1/ASC is a frequent event in prostate cancer, thus identifying a new potential diagnostic and prognostic marker for the treatment of the disease. Racial differences in TMS1/ASC methylation patterns implicate the probable role of molecular markers in determining in susceptibility to prostate cancer in different ethnic groups.

  10. Overall accuracy of cervical cytology and clinicopathological significance of LSIL cells in ASC-H cytology.

    Science.gov (United States)

    Kim, S H; Lee, J M; Yun, H G; Park, U S; Hwang, S U; Pyo, J-S; Sohn, J H

    2017-02-01

    The aims of this study were (i) to investigate the diagnostic accuracy of Papanicolaou (Pap) smears and (ii) to evaluate the clinicopathological significance of the presence of low-grade squamous intraepithelial lesion (LSIL) cells in atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (HSIL) (ASC-H) cytology. We retrospectively reviewed paired cytological and histological findings from 3141 patients. ASC-H cytology was classified as either ASC-H or LSIL with some features suggestive of the presence of a concurrent HSIL (LSIL-H). Clinicopathological characteristics were evaluated through a retrospective study and meta-analysis. The accuracy of the cytological diagnosis was 93.7% (2942 of 3141 cases). The positive predictive value (PPV) of ASC-H for cervical intraepithelial neoplasia grade 2 or worse (CIN 2+ ) was 51.4%. In cases of LSIL-H, CIN 2+ histology was more prevalent in the pre-menopausal period (19-44 years) than in peri- and postmenopausal periods (older than 45 years) (P = 0.024). There was no difference in the ability of LSIL-H and ASC-H to predict CIN 2+. The Pap smear is a good cervical cancer screening method. Although there was no difference in the predictive value for CIN 2+ between LSIL-H and ASC-H, the presence of definite LSIL cells was more predictive of CIN 2+ in younger patients than in older patients. © 2016 John Wiley & Sons Ltd.

  11. Load Calculation of the American Criterion ASCE74%浅析美国规范ASCE74中的荷载计算

    Institute of Scientific and Technical Information of China (English)

    薛英

    2012-01-01

      在国际工程标书中,美国输电线路结构荷载导则《Guidelines for Electrical Transmission Line Structural Loading》(ASCE74-2009)经常是被业主青睐和采用的标准。本文结合工程实际介绍了ASCE74中,线路在大风工况、覆冰工况、安装维护以及断线等工况下的荷载计算,可供国际工程投标及设计使用。%  The requirements of(ASCE 74-2009) have been adopted in many international transmission line projects. The article introduced the basic requirements for extreme wind, ice and wind loading, construction&maintenance and for longitudinal load in ASCE74, which may be taken as the reference for the tender documents and design.

  12. Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

    Directory of Open Access Journals (Sweden)

    Zeynep Tosuner

    2017-01-01

    Full Text Available Aims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A and minichromosome maintenance protein 2 (MCM2 in abnormal interpreted smears. Settings and Design: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A and minichromosome maintenance protein 2 (MCM2 has been considered to have tight association with high grade intraepithelial lesions. Materials and Methods: A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells-undetermined significance (ASC-US, atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H, low grade squamous intraepithelial lesion (LSIL, and high grade squamous intraepithelial lesion (HSIL were included in our study. Results and Conclusions: ProEx C was positive in 14 of HSILs (100%, 3 of 19 LSILs (16%, 2 of 4 ASC-Hs, and none of ASC-USs (0%. The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.

  13. A Linguistic Study of Borrowings from English to Urdu

    Directory of Open Access Journals (Sweden)

    Muhammad Aslam Sipra

    2013-01-01

    Full Text Available This paper discusses how English came into contact with Urdu language. Moreover, it outlines factors involved in borrowing from English to Urdu. It substantiates the influence of English on Urdu and demonstrates the conscious and unconscious shift of vocabulary items from one language to another during the interaction between speakers speaking different languages under any circumstances. The present study also unravels how people came across English in the Sub-continent. Pre-partition and post partition attitude of the people of the subcontinent towards English and the influence of English on Urdu are also bespoken.Keywords: Language, borrowing, influence, English, loan words, Urdu, contact

  14. The customers borrowing behavior during the financial crisis

    Directory of Open Access Journals (Sweden)

    Alina LUCA (BRĂTUCU

    2013-05-01

    Full Text Available The global financial crisis determined the transition of the Romanian banking system from excess of liquidity to deficit, namely from an aggressive lending activity to a significant reduction of credit growth rate. In our country, the high indebtedness rate, especially in foreign currencies, is the main vulnerable spot of the population sector. The main objective of this paperwork is to analyze factors that influence the customers in their decision to borrow in foreign currencies or in Ron. In this matter, it was used a regional econometric model for panel data in order to see Romania’s customers borrowing preferences and to analyze if the crises have changed their behavior.

  15. Scared away? Discouraged borrowers and Capital market information

    DEFF Research Database (Denmark)

    Christensen, Jesper Lindgaard; Hain, Daniel S.

    2014-01-01

    of discouraged borrowers. Implications Implications entail missed opportunities for firms, which in turn is likely to have deterrent effects on overall investments and economic growth. Financial institutions will miss out on business opportunities but will also have difficulties in fine-tuning their credit......We do the first study on discouraged borrowers in Denmark to firstly investigate the extent of this phenome-non in Denmark. Secondly, we test if characteristics of firms (age, size, innovativeness, industry) impact their likelihood of being discouraged from entering the capital markets. Thirdly...

  16. Scared away? Discouraged borrowers and Capital market information

    DEFF Research Database (Denmark)

    Christensen, Jesper Lindgaard; Hain, Daniel S.

    2014-01-01

    We do the first study on discouraged borrowers in Denmark to firstly investigate the extent of this phenome-non in Denmark. Secondly, we test if characteristics of firms (age, size, innovativeness, industry) impact their likelihood of being discouraged from entering the capital markets. Thirdly......, and most importantly, we test if the self-perception of firms regarding their near-future development is a stronger predictor of discouragement than objective firm characteristics. Prior Work; Earlier studies call for more empirical work on the extent and scale of discouraged borrowers, especially...

  17. Languages in Contact: A Bibliographical Guide to Linguistic Borrowings between English and Spanish

    Science.gov (United States)

    Fraser, Howard M.

    1975-01-01

    This bibliography on cross-cultural, Spanish/English linguistic borrowing consists of 185 items, virtually all of which are annotated. The bibliography is preceded by a discussion of the linguistic communities and the classification of borrowings. (KM)

  18. Linking Consumer Debt and Consumer Expenditures: Do Borrowers Spend Money Differently?

    Science.gov (United States)

    Fan, Jessie X.

    2000-01-01

    Data from 5,174 households were analyzed to investigate differences in spending patterns between households who borrow money and those who do not. Findings indicate that borrowers spend less money on necessities and more on luxury commodities. (JOW)

  19. Cross-Linguistic Transfer and Borrowing in Bilinguals

    Science.gov (United States)

    Marian, Viorica; Kaushanskaya, Margarita

    2007-01-01

    Cross-linguistic borrowing (overt use of words from the other language) and transfer (use of semantic or syntactic structures from the other language without active switching to that language) were examined during language production in Russian-English bilinguals. Grammatical category (noun/verb) and level of concreteness were found to influence…

  20. 12 CFR 618.8310 - Lists of borrowers and stockholders.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Lists of borrowers and stockholders. 618.8310 Section 618.8310 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM GENERAL PROVISIONS... after receipt of a written request by a stockholder, each Farm Credit bank or association must provide...

  1. Constraints on morphological borrowing: evidence from Latin America

    NARCIS (Netherlands)

    Bakker, D.; Hekking, E.

    2012-01-01

    In this article, we discuss the borrowing of morphology from Spanish by three unrelated and typologically diffferent American-Indian languages: Quechua, Guarani and Otomi. On the basis of three corpora of spontaneous speech produced by a sizeable number of informants, we will suggest that there are

  2. 12 CFR 615.5260 - Retirement of eligible borrower stock.

    Science.gov (United States)

    2010-01-01

    ... Section 615.5260 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL... equities for which such eligible borrower stock is exchanged in connection with a merger, consolidation, or... merger, consolidation or other reorganization or a transfer of territory. (2) Retirement in the...

  3. 24 CFR 891.740 - Responsibilities of Borrower.

    Science.gov (United States)

    2010-04-01

    ... homeless in the same housing market. (2) Marketing must be done in accordance with the HUD-approved affirmative fair housing marketing plan and all fair housing and equal opportunity requirements. The purpose...) Marketing. (1) The Borrower must commence and continue diligent marketing activities not later than 90...

  4. 12 CFR 615.5030 - Borrowings from commercial banks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Borrowings from commercial banks. 615.5030 Section 615.5030 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL... commercial banks. (a) Each System bank board, by resolution, shall authorize all commercial bank...

  5. 34 CFR 674.42 - Contact with the borrower.

    Science.gov (United States)

    2010-07-01

    ... indebtedness of students who have obtained Perkins loans for attendance at the institution or in the borrower's... stated interest rate on the loan. (5) The repayment schedule for all loans covered by the disclosure... institution. As an alternative, in the case of a student enrolled in a correspondence program or a study...

  6. Empathy from a nursing perspective: Moving beyond borrowed theory.

    Science.gov (United States)

    Walker, K M; Alligood, M R

    2001-06-01

    Empathy is a concept deeply rooted in and central to professional nursing. Although viewed as an important concept, little consensus exists in the professional literature about either the definition or the application of the concept to nursing practice. This article will compare two theories of empathy, one borrowed from Kohut's self-psychology model and one derived from King's Interacting Systems nursing framework. The two theories are examined to clarify issues pertaining to the concept of empathy and to identify the contributions and limitations of borrowed theory as the basis for nursing practice. The article explores similarities and difference in the two views of empathy and highlights the necessity of developing nursing science from theory based in nursing which reflects the very unique nature of nursing practice. Nursing as a profession is distinct and unique, and borrowed theory must be questioned for its fit and applicability to the profession. The article concludes that empathy is a nursing phenomenon needing to be studied from a nursing perspective. The results of continued use of borrowed theory pertaining to empathy is discussed including the delay and misdirection of ongoing activity to develop the concept of empathy.

  7. Living on borrowed time: experiences in palliative care.

    NARCIS (Netherlands)

    Groot, M.M.; Derksen, E.W.C.; Crul, B.J.P.; Grol, R.P.T.M.; Vernooij-Dassen, M.J.F.J.

    2007-01-01

    OBJECTIVE: To gain insight into the experiences of a palliative care patient and her husband who were living on borrowed time. METHODS: A qualitative single case design was used. Systematic content analysis of the interview data, obtained in an in-depth semi-structured interview, from the husband an

  8. Cross-National Policy Borrowing: Understanding Reception and Translation

    Science.gov (United States)

    Steiner-Khamsi, Gita

    2014-01-01

    The article examines two key concepts in research on policy borrowing and lending that are often used to explain why and how educational reforms travel across national boundaries: reception and translation. The studies on reception analyse the political, economic, and cultural reasons that account for the attractiveness of a reform from elsewhere.…

  9. Leasing versus Borrowing: Evaluating Alternative Forms of Consumer Credit.

    Science.gov (United States)

    Nunnally, Bennie H., Jr.; Plath, D. Anthony

    1989-01-01

    Presents a straightforward method for evaluating lease versus borrow (buy) decisions illustrated with actual financing cost data reported to new car purchasers. States that individuals should consider after-tax cash flows associated with alternative arrangements, time in which cash flow occurs, and opportunity cost of capital to identify the least…

  10. Cross-Linguistic Transfer and Borrowing in Bilinguals

    Science.gov (United States)

    Marian, Viorica; Kaushanskaya, Margarita

    2007-01-01

    Cross-linguistic borrowing (overt use of words from the other language) and transfer (use of semantic or syntactic structures from the other language without active switching to that language) were examined during language production in Russian-English bilinguals. Grammatical category (noun/verb) and level of concreteness were found to influence…

  11. 7 CFR 1779.75 - Defaults by borrower.

    Science.gov (United States)

    2010-01-01

    ...) Lender notification to Agency. The lender must notify the Agency when a borrower is 30 days past due on a payment, has not met its responsibilities of providing the required financial statements, or is otherwise...) must strengthen the loan and be in the best financial interest of the lender and the Agency. Some...

  12. 7 CFR 3575.75 - Defaults by borrower.

    Science.gov (United States)

    2010-01-01

    ... not met its responsibilities of providing the required financial statements, or is otherwise in...) must strengthen the loan and be in the best financial interest of the lender and the Agency. Some of... AGRICULTURE GENERAL Community Programs Guaranteed Loans § 3575.75 Defaults by borrower. (a)...

  13. 75 FR 10411 - Borrower Rights; Effective Interest Rates; Effective Date

    Science.gov (United States)

    2010-03-08

    ... 12 CFR Part 617 RIN 3052-AC45 Borrower Rights; Effective Interest Rates; Effective Date AGENCY: Farm Credit Administration. ACTION: Notice of effective date. SUMMARY: The Farm Credit Administration (FCA or... efficient manner. In accordance with 12 U.S.C. 2252, the effective date of the final rule is 30 days...

  14. 75 FR 59865 - Short-Term Borrowings Disclosure

    Science.gov (United States)

    2010-09-28

    ... registrant to provide, in a separately captioned subsection of Management's Discussion and Analysis of... the terminology contained in the proposed short-term borrowings disclosure requirement. In a companion... liquidity and capital resources in Management's Discussion and Analysis of Financial Condition and...

  15. Trade credit, collateral liquidation and borrowing constraints

    NARCIS (Netherlands)

    Fabbri, D.; Menichini, A.M.C.

    2009-01-01

    The paper proposes a model of collateralized bank and trade credit. Firms use a two-input technology. Assuming that the supplier is better able to extract value from existing assets and has an information advantage over other creditors, the paper derives a series of predictions. (1) Financially

  16. 12 CFR 617.7015 - What happens to borrower rights when a loan is sold?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What happens to borrower rights when a loan is sold? 617.7015 Section 617.7015 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS General § 617.7015 What happens to borrower rights when a loan is sold? (a) What...

  17. 7 CFR 3560.405 - Borrower organizational structure or ownership interest changes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Borrower organizational structure or ownership... Servicing § 3560.405 Borrower organizational structure or ownership interest changes. (a) General. The requirements of this section apply to changes in a borrower entity's organizational structure or to a change in...

  18. The Metaphor of Borrowing: Implications for the Theory of Language Evolution. A Response to Henriette Walter.

    Science.gov (United States)

    Gardner-Chloros, Penelope

    1999-01-01

    Discusses a previous article on linguistic borrowing in the French language and argues that the metaphor "borrowing" (with its linguistic equivalents in French and German) is approximate. Suggests because the family tree model has been discredited as has the notion of a standard language, borrowings are merely the "tip of the iceberg" in the…

  19. 12 CFR 615.5040 - Borrowings from financial institutions other than commercial banks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Borrowings from financial institutions other... § 615.5040 Borrowings from financial institutions other than commercial banks. The Farm Credit banks may borrow from other financial institutions, such as insurance companies, Federal agencies, or...

  20. 7 CFR 1710.251 - Construction work plans-distribution borrowers.

    Science.gov (United States)

    2010-01-01

    ...) Transmission and substation facilities required to support the distribution system; (6) Distribution equipment... 7 Agriculture 11 2010-01-01 2010-01-01 false Construction work plans-distribution borrowers. 1710...—distribution borrowers. (a) All distribution borrowers must maintain a current CWP approved by their board...

  1. 7 CFR 1780.47 - Borrower accounting methods, management reporting and audits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Borrower accounting methods, management reporting and... Grant Application Processing § 1780.47 Borrower accounting methods, management reporting and audits. (a) Borrowers are required to provide RUS an annual audit or financial statements. (b) Method of accounting and...

  2. Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC.

    Science.gov (United States)

    Mellor, Liliana F; Steward, Andrew J; Nordberg, Rachel C; Taylor, Michael A; Loboa, Elizabeth G

    2017-04-01

    Cartilage tissue engineering is a growing field due to the lack of regenerative capacity of native tissue. The use of bioreactors for cartilage tissue engineering is common, but the results are controversial. Some studies suggest that microgravity bioreactors are ideal for chondrogenesis, while others show that mimicking hydrostatic pressure is crucial for cartilage formation. A parallel study comparing the effects of loading and unloading on chondrogenesis has not been performed. The goal of this study was to evaluate chondrogenesis of human adipose-derived stem cells (hASC) under two different mechanical stimuli relative to static culture: microgravity and cyclic hydrostatic pressure (CHP). Pellets of hASC were cultured for 14 d under simulated microgravity using a rotating wall vessel bioreactor or under CHP (7.5 MPa, 1 Hz, 4 h · d-1) using a hydrostatic pressure vessel. We found that CHP increased mRNA expression of Aggrecan, Sox9, and Collagen II, caused a threefold increase in sulfated glycosaminoglycan production, and resulted in stronger vimentin staining intensity and organization relative to microgravity. In addition, Wnt-signaling patterns were altered in a manner that suggests that simulated microgravity decreases chondrogenic differentiation when compared to CHP. Our goal was to compare chondrogenic differentiation of hASC using a microgravity bioreactor and a hydrostatic pressure vessel, two commonly used bioreactors in cartilage tissue engineering. Our results indicate that CHP promotes hASC chondrogenesis and that microgravity may inhibit hASC chondrogenesis. Our findings further suggest that cartilage formation and regeneration might be compromised in space due to the lack of mechanical loading.Mellor LF, Steward AJ, Nordberg RC, Taylor MA, Loboa EG. Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC. Aerosp Med Hum Perform. 2017; 88(4):377-384.

  3. ASC-H in Pap test- definitive categorization of cytomorphological spectrum

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2006-05-01

    Full Text Available Abstract Objective The American Society for Colposcopy and Cervical Pathology (ASCCP guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The purpose of this study was to evaluate association of various cytomorphological patterns of ASC-H with various clinical scenarios. Methods We reviewed SurePath™ (TriPath Imaging, Inc. Burlington, NC, USA cervical smears interpreted as ASC-H in 161 women (mean age, 37 {15 to 78} years, over 24 months (2002 to 2003. HPVT (Digene, Hybrid Capture® II HPV test, Digene Corporation, Gaithersburg, MD, USA was performed in 20% of cases (33/161 and biopsy results were available in 54 cases (19 with and 35 without HPVT. Results HPVT was positive in 64% (21/33 cases, and negative in 36% (12/33 cases. In the follow-up biopsies of 71% (15/21 of cases with positive HPVT, 27% showed HPV changes or CIN1, 27% showed CIN2-3, and 46% were negative for epithelial abnormality. Follow-up biopsies from cases with negative HPVT (33%, 4/12 cases, 8% showed CIN1 and 25% were negative for any epithelial abnormality. Six cytomorphological patterns of ASC-H correlated with different clinical categories in relation to HPVT and biopsy results. 35% (19 out of 54 ASC-H cases in which biopsy results were available could be interpreted definitively as HSIL by cytopathology, 11% (6/54 cases as LSIL with cyanophilic atypical parakeratotic pattern, and 31% (17/54 cases as reactive, with HPV status. The interpretation had to be continued as ASC-H in 22% (12/54 cases. Conclusion ASC-H demonstrated a spectrum of cytomorphological patterns. Some of these patterns in liquid-based cervical smears may be more specifically interpreted as LSIL, HSIL, or benign if HPV status is known.

  4. Fundamentals of civil engineering an introduction to the ASCE body of knowledge

    CERN Document Server

    McCuen, Richard H; Wong, Melanie K

    2011-01-01

    While the ASCE Body of Knowledge (BOK2) is the codified source for all technical and non-technical information necessary for those seeking to attain licensure in civil engineering, recent graduates have notoriously been lacking in the non-technical aspects even as they excel in the technical. Fundamentals of Civil Engineering: An Introduction to the ASCE Body of Knowledge addresses this shortfall and helps budding engineers develop the knowledge, skills, and attitudes suggested and implied by the BOK2. Written as a resource for all of the non-technical outcomes not specifically covered in the

  5. MicroASC instrument onboard Juno spacecraft utilizing inertially controlled imaging

    DEFF Research Database (Denmark)

    Pedersen, David Arge Klevang; Jørgensen, Andreas Härstedt; Benn, Mathias

    2016-01-01

    This contribution describes the post-processing of the raw image data acquired by the microASC instrument during the Earth-fly-by of the Juno spacecraft. The images show a unique view of the Earth and Moon system as seen from afar. The procedure utilizes attitude measurements and inter......-calibration of the Camera Head Units of the microASC system to trigger the image capturing. The triggering is synchronized with the inertial attitude and rotational phase of the sensor acquiring the images. This is essentially works as inertially controlled imaging facilitating image acquisition from unexplored...

  6. The Big Australian Speech Corpus (The Big ASC)

    NARCIS (Netherlands)

    Wagner, M.; Tran, D.; Togneri, R.; Rose, P.; Powers, D.M.; Onslow, M.; Loakes, D.E.; Lewis, T.W.; Kuratate, T.; Kinoshita, Y.; Kemp, N.; Ishihara, S.; Ingram, J.C.; Hajek, J.T.; Grayden, D.B.; Goecke, R.; Fletcher, J.M.; Estival, D.; Epps, J.R.; Dale, R.; Cutler, A.; Cox, F.M.; Chetty, G.; Cassidy, S.; Butcher, A.R.; Burnham, D.; Bird, S.; Best, C.T.; Bennamoun, M.; Arciuli, J.; Ambikairajah, E.

    2011-01-01

    Under an ARC Linkage Infrastructure, Equipment and Facilities (LIEF) grant, speech science and technology experts from across Australia have joined forces to organise the recording of audio-visual (AV) speech data from representative speakers of Australian English in all capital cities and some regi

  7. The role and importance of the enterprise`s borrowed capital

    Directory of Open Access Journals (Sweden)

    Dombrovska Sofiіa Oleksiyivna

    2016-06-01

    Full Text Available The paper presents scientific views of researches regarding the definition of “borrowed capital”. The basic functions of borrowed capital have been submitted, its classification on various grounds is highlighted. The article describes the features of borrowed capital, its advantages and disadvantages, considers management system of borrowed capital and problems of domestic enterprises in modern conditions of economic relations. The author proposed the main directions of the management improving of borrowed capital. The information will be useful for specialists in the field of financial management.

  8. Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma

    NARCIS (Netherlands)

    Liu, W.; Luo, Y.; Dunn, J.H.; Norris, D.A.; Dinarello, C.A.; Fujita, M.

    2013-01-01

    Apoptosis-associated Speck-like protein containing a CARD (caspase recruitment domain) (ASC) was originally named because it triggered apoptosis in certain tumors. More recently, however, ASC was found to be a central adaptor protein of inflammasome, which mediates the secretion of protumorigenic

  9. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

    Science.gov (United States)

    Domiciano, Talita P.; Wakita, Daiko; Jones, Heather D.; Crother, Timothy R.; Verri, Waldiceu A.; Arditi, Moshe; Shimada, Kenichi

    2017-01-01

    Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique protease, caspase-1, which is activated by various protein platforms called inflammasomes. Data suggests a key role for mitochondrial reactive oxygen species for inflammasome activation. Flavonoids constitute a group of naturally occurring polyphenolic molecules with many biological activities, including antioxidant effects. In this study, we investigated the effect of three flavonoids, quercetin (QUC), naringenin, and silymarim on inflammasome activation. We found that QUC inhibits IL-1β secretion by both the NLRP3 and AIM2 inflammasome in a dose dependent manner, but not the NLRC4 inflammasome. QUC inhibition of the inflammasome was still observed in Atg16l1 knockout macrophages, indicating that QUC’s effect was autophagy independent. Since QUC inhibited both NLRP3 and AIM2 inflammasomes but not NLRC4, we assessed ASC speck formation. QUC reduced ASC speck formation and ASC oligomerization compared with controls. Additionally, QUC inhibited IL-1β in Cryopyrin-Associated Periodic Syndromes (CAPS) macrophages, where NLRP3 inflammasome is constitutively activated. In conclusion, QUC inhibits both the NLRP3 and AIM2 inflammasome by preventing ASC oligomerization and may be a potential therapeutic candidate for Kawasaki disease vasculitis and other IL-1 mediated inflammatory diseases. PMID:28148962

  10. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.

    Science.gov (United States)

    Domiciano, Talita P; Wakita, Daiko; Jones, Heather D; Crother, Timothy R; Verri, Waldiceu A; Arditi, Moshe; Shimada, Kenichi

    2017-02-02

    Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique protease, caspase-1, which is activated by various protein platforms called inflammasomes. Data suggests a key role for mitochondrial reactive oxygen species for inflammasome activation. Flavonoids constitute a group of naturally occurring polyphenolic molecules with many biological activities, including antioxidant effects. In this study, we investigated the effect of three flavonoids, quercetin (QUC), naringenin, and silymarim on inflammasome activation. We found that QUC inhibits IL-1β secretion by both the NLRP3 and AIM2 inflammasome in a dose dependent manner, but not the NLRC4 inflammasome. QUC inhibition of the inflammasome was still observed in Atg16l1 knockout macrophages, indicating that QUC's effect was autophagy independent. Since QUC inhibited both NLRP3 and AIM2 inflammasomes but not NLRC4, we assessed ASC speck formation. QUC reduced ASC speck formation and ASC oligomerization compared with controls. Additionally, QUC inhibited IL-1β in Cryopyrin-Associated Periodic Syndromes (CAPS) macrophages, where NLRP3 inflammasome is constitutively activated. In conclusion, QUC inhibits both the NLRP3 and AIM2 inflammasome by preventing ASC oligomerization and may be a potential therapeutic candidate for Kawasaki disease vasculitis and other IL-1 mediated inflammatory diseases.

  11. The standardized psychometric assessment of altered states of consciousness (ASCs) in humans.

    Science.gov (United States)

    Dittrich, A

    1998-07-01

    The APZ questionnaire was developed in order to explore hypotheses on ASCs. First -- in a series of 11 experiments using different induction methods on N = 393 healthy subjects -- the hypothesis was tested that ASCs have major dimensions in common irrespective of the mode of their induction. In the International Study on Altered States of Consciousness (ISASC) the external validity of the experimental results was assessed. The ISASC was carried out on a total of N = 1133 subjects in six countries. The main results of the experimental studies were corroborated in the field studies. The results can be summarized as follows: the common denominator of ASCs is described by three oblique dimensions, designated as "Oceanic Boundlessness (OSE)", "Dread of Ego Dissolution (AIA)" and "Visionary Restructuralization (VUS)". The reliability and validity of the scales are satisfactory. Tested versions of the APZ scales are available in English (UK, USA), German, Italian and Portuguese. Psychometrically as yet untested versions exist in Dutch, Finnish, French, Greek, Spanish and Russian. The APZ questionnaire has become the international standard for the assessment of ASCs, thus helping to integrate research. A psychometrically improved version exists in German (OAV questionnaire). The BETA questionnaire, which measures the dimensions "Vigilance Reduction (VIR)" and "Auditive Alteration (AVE)" is also available in German. These dimensions are most likely etiology-dependent.

  12. 18 CFR Appendix 1 to Part 301 - ASC Utility Filing Template

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false ASC Utility Filing Template 1 Appendix 1 to Part 301 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS FOR FEDERAL POWER MARKETING ADMINISTRATIONS AVERAGE SYSTEM...

  13. ASC Computational Environment (ACE) requirements version 8.0 final report.

    Energy Technology Data Exchange (ETDEWEB)

    Larzelere, Alex R. (Exagrid Engineering, Alexandria, VA); Sturtevant, Judith E.

    2006-11-01

    A decision was made early in the Tri-Lab Usage Model process, that the collection of the user requirements be separated from the document describing capabilities of the user environment. The purpose in developing the requirements as a separate document was to allow the requirements to take on a higher-level view of user requirements for ASC platforms in general. In other words, a separate ASC user requirement document could capture requirements in a way that was not focused on ''how'' the requirements would be fulfilled. The intent of doing this was to create a set of user requirements that were not linked to any particular computational platform. The idea was that user requirements would endure from one ASC platform user environment to another. The hope was that capturing the requirements in this way would assist in creating stable user environments even though the particular platforms would be evolving and changing. In order to clearly make the separation, the Tri-lab S&CS program decided to create a new title for the requirements. The user requirements became known as the ASC Computational Environment (ACE) Requirements.

  14. Fairness based channel borrowing strategy in multimedia LEO satellite communications

    Institute of Scientific and Technical Information of China (English)

    HUANG Fei; XU Hui; WU Shiqi

    2007-01-01

    A novel bandwidth allocation strategy along with a connection admission control technique was proposed to improve the utilization of network resources.It provides the network with better quality-of-service (QoS) guarantees,such as new call blocking probability (CBP) and handoff call dropping probability (CDP) in multimedia low earth orbit (LEO) satellite networks.Simulation results show that,compared with other bandwidth allocation schemes,the proposed scheme offers very low call dropping probability for real-time connections while,at the same time,keeping resource utilization high.Finally we discussed the fairness for the borrowed nonreal-time connections under three different channel borrowing methods.

  15. Mimesis, Memory, and Borrowed Materials: A Portfolio of Compositions

    OpenAIRE

    Bunce, Guy

    2013-01-01

    This thesis consists of a portfolio of nine musical compositions with accompanying recordings and commentary. The works included range from solo chamber music to large ensemble and explore the notions of mimesis, memory, and borrowed materials in musical composition. The commentary begins by providing a framework and historical context to the portfolio and in particular explores mimesis as an æsthetic device across the centuries and art forms. Music for amateurs and multiple tempi are then pr...

  16. Composite PLGA/AgNpPGA/AscH nanospheres with combined osteoinductive, antioxidative, and antimicrobial activities.

    Science.gov (United States)

    Stevanović, Magdalena; Uskoković, Vuk; Filipović, Miloš; Škapin, Srečo D; Uskoković, Dragan

    2013-09-25

    The global rise in the resistance of pathogens to conventional antibiotics has created an intensive search for alternative materials with antimicrobial properties. This study is performed with an intention to investigate the combined effects of poly(l-glutamic acid)-capped silver nanoparticles (AgNpPGA) and ascorbic acid (AscH) encapsulated within freeze-dried poly(lactide-co-glycolide) (PLGA) nanospheres to obtain a nanomaterial with simultaneous osteoinductive, antioxidative, and prolonged antimicrobial properties. The influence of PLGA/AgNpPGA/AscH particles on (i) viability and superoxide production of human umbilical vein endothelial cells in vitro, (ii) morphology and expression of osteogenic markers in osteoblastic MC3T3-E1 cells in vitro, and (iii) antimicrobial activity against a Gram-positive bacterium, methicillin-resistant Staphylococcus aureus, and a Gram-negative bacterium, Escherichia coli, was investigated. PLGA/AgNpPGA/AscH nanoparticles showed a superior and extended antibacterial activity against both types of bacteria. The nanoparticles appeared to be capable of delivering ascorbate to the cells, which was evidenced by the significant decrease in the level of superoxides in human umbilical vein endothelial cells and which could have a therapeutic potential in preventing oxidative stress. PLGA/AgNpPGA/AscH nanoparticles had a positive effect on MC3T3-E1 osteoblastic cells in vitro, promoting: (i) an intimate contact with the cells and preservation of their healthy morphologies; (ii) unreduced cell viability; and (iii) multiple-fold upregulation of two osteogenic markers: osteocalcin and type I procollagen. It is concluded that PLGA/AgNpPGA/AscH nanospheres present a promising new material for the treatment of infections and use in wound dressings and other prophylactic applications.

  17. Study of ASC in Cervical Exfoliated Cytology%宫颈脱落细胞学中 ASC 的研究与分析

    Institute of Scientific and Technical Information of China (English)

    张志兴

    2015-01-01

    Objective To investigate the significance of thinprep cytoligic test (TCT) in the diagnosis of atypical squamous cells.Methods A retrospective analysis was conducted among TCT samples from which those with atypical squamous cells were diag-nosed from July 2012 till July 2014.Results Of all 349 cases, 152 were HPV-positive, and 44.7% were diagnosed with cervical intraepithelial neoplasia or cervical cancer; among 197 cases of HPV-negative patients, 8 cases of patients were with cervical intraepi-thelial neoplasia or cervical cancer.since atypical squamous cells were correlated with age, women older than 40 years old composed the main part of ASC.Conclusion TCT was meaningful for an early detection of cervical lesions and cervical cancer.Increasing awareness of ASC and attention to patients may avoid delay in diagnosis and treatment of cervical lesions.%目的:探讨薄层液基细胞学检测(Thinprep cytoligic test, TCT)在诊断非典型鳞状细胞的意义。方法回顾性分析某医院2012年7月至2014年7月期间 TCT 标本中诊断为非典型鳞状细胞患者的结局。结果349例宫颈非典型鳞状细胞中,152例患者 HPV 阳性,44.7%存在宫颈上皮内瘤变或宫颈癌;197例 HPV 阴性患者中,8例患者存在宫颈上皮内瘤变或宫颈癌。同时非典型鳞状细胞的诊断与年龄存在相关性,年龄在40岁以上的妇女被诊断为 ASC 的人数较多。结论宫颈 TCT 及 HPV 筛查对于宫颈癌前病变及宫颈癌的早期发现有重要价值。应提高对 ASC 认识及对患者重视,以免耽误宫颈病变的诊断和治疗。

  18. Networks uncover hidden lexical borrowing in Indo-European language evolution

    Science.gov (United States)

    Nelson-Sathi, Shijulal; List, Johann-Mattis; Geisler, Hans; Fangerau, Heiner; Gray, Russell D.; Martin, William; Dagan, Tal

    2011-01-01

    Language evolution is traditionally described in terms of family trees with ancestral languages splitting into descendent languages. However, it has long been recognized that language evolution also entails horizontal components, most commonly through lexical borrowing. For example, the English language was heavily influenced by Old Norse and Old French; eight per cent of its basic vocabulary is borrowed. Borrowing is a distinctly non-tree-like process—akin to horizontal gene transfer in genome evolution—that cannot be recovered by phylogenetic trees. Here, we infer the frequency of hidden borrowing among 2346 cognates (etymologically related words) of basic vocabulary distributed across 84 Indo-European languages. The dataset includes 124 (5%) known borrowings. Applying the uniformitarian principle to inventory dynamics in past and present basic vocabularies, we find that 1373 (61%) of the cognates have been affected by borrowing during their history. Our approach correctly identified 117 (94%) known borrowings. Reconstructed phylogenetic networks that capture both vertical and horizontal components of evolutionary history reveal that, on average, eight per cent of the words of basic vocabulary in each Indo-European language were involved in borrowing during evolution. Basic vocabulary is often assumed to be relatively resistant to borrowing. Our results indicate that the impact of borrowing is far more widespread than previously thought. PMID:21106583

  19. Networks uncover hidden lexical borrowing in Indo-European language evolution.

    Science.gov (United States)

    Nelson-Sathi, Shijulal; List, Johann-Mattis; Geisler, Hans; Fangerau, Heiner; Gray, Russell D; Martin, William; Dagan, Tal

    2011-06-22

    Language evolution is traditionally described in terms of family trees with ancestral languages splitting into descendent languages. However, it has long been recognized that language evolution also entails horizontal components, most commonly through lexical borrowing. For example, the English language was heavily influenced by Old Norse and Old French; eight per cent of its basic vocabulary is borrowed. Borrowing is a distinctly non-tree-like process--akin to horizontal gene transfer in genome evolution--that cannot be recovered by phylogenetic trees. Here, we infer the frequency of hidden borrowing among 2346 cognates (etymologically related words) of basic vocabulary distributed across 84 Indo-European languages. The dataset includes 124 (5%) known borrowings. Applying the uniformitarian principle to inventory dynamics in past and present basic vocabularies, we find that 1373 (61%) of the cognates have been affected by borrowing during their history. Our approach correctly identified 117 (94%) known borrowings. Reconstructed phylogenetic networks that capture both vertical and horizontal components of evolutionary history reveal that, on average, eight per cent of the words of basic vocabulary in each Indo-European language were involved in borrowing during evolution. Basic vocabulary is often assumed to be relatively resistant to borrowing. Our results indicate that the impact of borrowing is far more widespread than previously thought.

  20. Ascídias (Tnicata, Ascidiacea) do Espírito Santo, Brasil

    OpenAIRE

    Gamba, Gustavo Antunes

    2013-01-01

    Resumo: De acordo com o banco de dados The World Register of Marine Species existem em torno de 2900 espécies de ascídias descritas. No Brasil, o conhecimento sobre a fauna desses animais é ainda insuficiente, com muitas espécies de ascídias ainda não conhecidas. Acredita-se que existam aproximadamente 130 espécies válidas no país, mas aproximadamente 100 estão atualmente registradas. O Espírito Santo é um dos vários estados brasileiros para o qual pouco se conhece a fauna desse táxon, pois o...

  1. Checklist das ascídias (Tunicata, Ascidiacea) do Estado de São Paulo, Brasil

    OpenAIRE

    Rocha,Rosana Moreira da; Dias,Gustavo Muniz; Lotufo,Tito Monteiro da Cruz

    2011-01-01

    Ascídias são organismos marinhos que, em sua maioria, vivem fixados a substratos consolidados desde as regiões costeiras até às grandes profundidades. Apesar de serem cordados, apresentam um plano corporal adulto muito modificado em função de seu hábito de vida. O Estado de São Paulo é o que apresenta o melhor conhecimento da fauna de ascídias, tanto em termos de sua biodiversidade como em aspectos ecológicos. No estado, a região do município de São Sebastião foi a mais estudada em função da ...

  2. ASC Tri-lab Co-design Level 2 Milestone Report 2015

    Energy Technology Data Exchange (ETDEWEB)

    Hornung, Rich [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jones, Holger [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Keasler, Jeff [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Neely, Rob [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pearce, Olga [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hammond, Si [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trott, Christian [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Rob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bergen, Ben [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Payne, Josh [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Womeldorff, Geoff [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-23

    In 2015, the three Department of Energy (DOE) National Laboratories that make up the Advanced Sci- enti c Computing (ASC) Program (Sandia, Lawrence Livermore, and Los Alamos) collaboratively explored performance portability programming environments in the context of several ASC co-design proxy applica- tions as part of a tri-lab L2 milestone executed by the co-design teams at each laboratory. The programming environments that were studied included Kokkos (developed at Sandia), RAJA (LLNL), and Legion (Stan- ford University). The proxy apps studied included: miniAero, LULESH, CoMD, Kripke, and SNAP. These programming models and proxy-apps are described herein. Each lab focused on a particular combination of abstractions and proxy apps, with the goal of assessing performance portability using those. Performance portability was determined by: a) the ability to run a single application source code on multiple advanced architectures, b) comparing runtime performance between \

  3. Precautionary Borrowing and the Credit Card Debt Puzzle

    DEFF Research Database (Denmark)

    Druedahl, Jeppe; Jørgensen, Casper Nordal

    2015-01-01

    This paper addresses the credit card debt puzzle using a generalization of the buffer-stock consumption model with long-term revolving debt contracts. Closely resembling actual US credit card law, we assume that card issuers can always deny their cardholders access to new debt, but that they cannot...... to simultaneously hold positive gross debt and positive gross assets even though the interest rate on the debt is much higher than the return rate on the assets. Including a risk of being excluded from new borrowing which is positively correlated with unemployment, we are able to simultaneously explain...

  4. Borrowing constraints and complex dynamics in an OLG framework

    DEFF Research Database (Denmark)

    Assenza, Tiziana; Agliari, Anna; Delli Gatti, Domenico

    2009-01-01

    In this paper we model an OLG economy à la Kiyotaki and Moore whose novel feature is the role of money as a store of value and of bequest as a source of funds to be "invested" in landholding. The dynamics generated by the model are generally characterized by irregular cyclical trajectories and, u......, under special configuration of the parameters, a strange attractor appears. In this setting, an expansionary monetary policy may have a stabilizing role due to the interaction between money holding and the accumulation of borrowers' net worth....

  5. Borrowings - a source of innovation in the class of interjections

    DEFF Research Database (Denmark)

    Sauciuc, Gabriela-Alina

    2006-01-01

    The present article is part of a larger project investigating the various types of linguistic change that affected and might affect the word class traditionally known under the label of interjection. The results of our research, as outlined here, concern the inter-linguistic mobility of units, i.......e., borrowings, which in the source language can be (but not necessarily) interjections, and which are still categorized - or re-categorized - as interjections in the target language. The inventory of interjections which constituted the corpus of the present study is therefore collected mainly from normative...

  6. Tying loan interest rates to borrowers' CDS spreads

    OpenAIRE

    Ivanov, Ivan T.; Santos, Joao A. C.; Vo, Thu

    2014-01-01

    We investigate how the introduction of market-based pricing, the practice of tying loan interest rates to credit default swaps, has affected borrowing costs. We find that CDS-based loans are associated with lower interest rates, both at origination and during the life of the loan. Our results also indicate that banks simplify the covenant structure of market-based pricing loans, suggesting that the decline in the cost of bank debt is explained, at least in part, by a reduction in monitoring c...

  7. ASC-H诊断的临床指导意义

    Institute of Scientific and Technical Information of China (English)

    白合尼莎·阿不都热西提; 迪丽努尔·吐尔逊

    2007-01-01

    目的 分析不除外高度上皮内病变的不典型鳞状上皮细胞(ASC-H)在宫颈病变中的诊断意义.方法 ASC-H病例行阴道镜检查并取活检,结果作对照分析.结果 细胞学诊断的40例ASCH病例中,33例有病理对照,其中有20例病理结果显示慢性宫颈炎,3例LSIL(低度鳞状上皮内病变)、8例HSIL(高度鳞状上皮内病变)、1例鳞状细胞癌(SCC)、1例息肉(polyp).结论 ASC-H有预示CIN2和CIN3的阳性价值.

  8. Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner.

    Directory of Open Access Journals (Sweden)

    Jung-Eun Koo

    Full Text Available Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium, which escapes from the endo/phagosome and replicates in the host cytoplasm. O. tsutsugamushi infection induces production of pro-inflammatory mediators including interleukin-1β (IL-1β, which is secreted mainly from macrophages upon cytosolic stimuli by activating cysteine protease caspase-1 within a complex called the inflammasome, and is a key player in initiating and maintaining the inflammatory response. However, the mechanism for IL-1β maturation upon O. tsutsugamushi infection has not been identified. In this study, we show that IL-1 receptor signaling is required for efficient host protection from O. tsutsugamushi infection. Live Orientia, but not heat- or UV-inactivated Orientia, activates the inflammasome through active bacterial uptake and endo/phagosomal maturation. Furthermore, Orientia-stimulated secretion of IL-1β and activation of caspase-1 are ASC- and caspase-1- dependent since IL-1β production was impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3-, Nlrc4- and Aim2-deficient macrophages. Therefore, live O. tsutsugamushi triggers ASC inflammasome activation leading to IL-1β production, which is a critical innate immune response for effective host defense.

  9. A Comparison of ASCE and FAO56 Reference Evapotranspiration at Different Subdaily Timescales: a Numerical Study

    Directory of Open Access Journals (Sweden)

    Farzin Parchami-Araghi

    2017-01-01

    Full Text Available Introduction: Subdaily estimates of reference evapotranspiration (ETo are needed in many applications such as dynamic agro-hydrological modeling. The ASCE and FAO56 Penman–Monteith models (ASCE-PM and FAO56-PM, respectively has received favorable acceptance and application over much of the world, including the United States, for establishing a reference evapotranspiration (ETo index as a function of weather parameters. In the past several years various studies have evaluated ASCE-PM and FAO56-PM models for calculating the commonest hourly or 15-min ETo either by comparing them with lysimetric measurements or by comparison with one another (2, 3, 5, 9, 10, 11, 16, 17, 19. In this study, sub-daily ET o estimates made by the ASCE-PM and FAO56-PM models at different timescales (1-360 min were compared through conduction of a computational experiment, using a daily to sub-daily disaggregation framework developed by Parchami-Araghi et al. (14. Materials and Methods: Daily and sub-daily weather data at different timescales (1-360 min were generated via a daily-to-sub-daily weather data disaggregation framework developed by Parchami-Araghi et al. (14, using long-term (59 years daily weather data obtained from Abadan synoptic weather station. Daily/sub-daily net long wave radiation (Rnl was estimated through 6 different approaches, including using two different criteria for identifying the daytime/nighttime periods : 1 the standard criteria implemented in both ASCE-PM and FAO56-PM models and 2 criterion of actual time of sunset and sunrise in combination with 1 estimation of clear-sky radiation (Rso based on the standard approach implemented in both ASCE-PM and FAO56-PM models (1st and 2nd Rnl estimation approaches, respectively, 2 integral of the Rso estimates derived via a physically based solar radiation model developed by Yang et al. (25, YNG model, for one-second time-steps (3rd and 4th Rnl estimation approaches, respectively, and 3 integral of

  10. The Astrobiology in Secondary Classroom (ASC) Curriculum Development Project: Focusing Upon Diverse Students and Teachers in the Pilot Testing Process

    Science.gov (United States)

    Butler, J.; Arino de La Rubia, L.; Gary, T.; Kuner, S.; Ceballos, R. M.; Pfiffner, S.; Brown, S.

    2010-04-01

    The ASC curriculum guide is designed to address the learning styles present in diverse classrooms by incorporating research-based teaching strategies that increase participation of underrepresented groups in STEM fields.

  11. Lexical borrowing by Khoekhoegowab from Cape Dutch and Afrikaans

    Directory of Open Access Journals (Sweden)

    Wilfrid Haacke

    2015-02-01

    Full Text Available The present article instantiates types of lexical borrowing from Afrikaans and Dutch in Namibian Khoekhoegowab (also known as “Nama”/“Damara”, but occasionally also refers to borrowings in the opposite direction. Where evidence allows, loans are traced back beyond Afrikaans to the era of Cape Dutch and contemporary interethnic contacts. Various categories ranging from adoptions to phonologically integrated loans, hybrids and calques are presented and, where possible, historical inferences are offered. The high degree of translational equivalence between Khoekhoe serial verbs and Afrikaans compound verbs leads to the consideration of some grammatical aspects including replication and relexification. Finally, reference is made to a parallel between Afrikaans and “Khoekhoe Afrikaans” syntax pointed out by den Besten (2013: Afrikaans circumlocutions like ek / sy wat Anna is (Khoekhoe: Anna.ta / Anna.s are literal equivalents of the underlying phrasal structures of Khoekhoe surface nouns #stem.pgn# in first, second or third person, as accounted for by the “desentential hypothesis” (Haacke 2006.  

  12. New therapy with ASC-J9® to suppress the prostatitis via altering the cytokine CCL2 signals.

    Science.gov (United States)

    Lin, Shin-Jen; Chou, Fu-Ju; Lin, Chang-Yi; Chang, Hong-Chiang; Yeh, Shuyuan; Chang, Chawnshang

    2016-10-11

    Prostatitis is a common disease contributing to 8% of all urologist visits. Yet the etiology and effective treatment remain to be further elucidated. Using a non-obese diabetes mouse model that can be induced by autoimmune response for the spontaneous development of prostatitis, we found that injection of the ASC-J9® at 75 mg/Kg body weight/48 hours led to significantly suppressed prostatitis that was accompanied with reduction of lymphocyte infiltration with reduced CD4+ T cells in prostate. In vitro studies with a co-culture system also confirmed that ASC-J9® treatment could suppress the CD4+ T cell migration to prostate stromal cells. Mechanisms dissection indicated that ASC-J9® can suppress CD4+ T cell migration via decreasing the cytokine CCL2 in vitro and in vivo, and restoring CCL2 could interrupt the ASC-J9® suppressed CD4+ T cell migration. Together, results from in vivo and in vitro studies suggest that ASC-J9® can suppress prostatitis by altering the autoimmune response induced by CD4+ T cell recruitment, and using ASC-J9® may help us to develop a potential new therapy to battle the prostatitis with little side effects.

  13. Engineering anatomically shaped vascularized bone grafts with hASCs and 3D-printed PCL scaffolds.

    Science.gov (United States)

    Temple, Joshua P; Hutton, Daphne L; Hung, Ben P; Huri, Pinar Yilgor; Cook, Colin A; Kondragunta, Renu; Jia, Xiaofeng; Grayson, Warren L

    2014-12-01

    The treatment of large craniomaxillofacial bone defects is clinically challenging due to the limited availability of transplantable autologous bone grafts and the complex geometry of the bones. The ability to regenerate new bone tissues that faithfully replicate the anatomy would revolutionize treatment options. Advances in the field of bone tissue engineering over the past few decades offer promising new treatment alternatives using biocompatible scaffold materials and autologous cells. This approach combined with recent advances in three-dimensional (3D) printing technologies may soon allow the generation of large, bioartificial bone grafts with custom, patient-specific architecture. In this study, we use a custom-built 3D printer to develop anatomically shaped polycaprolactone (PCL) scaffolds with varying internal porosities. These scaffolds are assessed for their ability to support induction of human adipose-derived stem cells (hASCs) to form vasculature and bone, two essential components of functional bone tissue. The development of functional tissues is assessed in vitro and in vivo. Finally, we demonstrate the ability to print large mandibular and maxillary bone scaffolds that replicate fine details extracted from patient's computed tomography scans. The findings of this study illustrate the capabilities and potential of 3D printed scaffolds to be used for engineering autologous, anatomically shaped, vascularized bone grafts.

  14. Students' Behaviors and Views of Paraphrasing and Inappropriate Textual Borrowing in an EFL Academic Setting

    Science.gov (United States)

    Liao, Ming-Tzu; Tseng, Chiung-Ying

    2010-01-01

    This study examines skillful EFL writers' and less skillful writers' EFL performance and perceptions of paraphrasing and inappropriate text borrowing, the extent to which their performance matches perceptions, and the factors behind their problematic text borrowing. Ninety-five postgraduates and undergraduates in Taiwan accomplished a paraphrasing…

  15. The Social Correlates of Lexical Borrowing in Spanish in New York City

    Science.gov (United States)

    Varra, Rachel Marie

    2013-01-01

    This dissertation investigates lexical borrowing in Spanish in New York. English-origin lexical material was extracted from a stratified sample of 146 Spanish-speaking informants of different ages, national origins, classes, etc., living in New York City. ANOVAs and Pearson correlations determined whether lexical borrowing frequency and the type…

  16. Education Policy Borrowing in China: Has the West Wind Overpowered the East Wind?

    Science.gov (United States)

    Tan, Charlene; Chua, Catherine S. K.

    2015-01-01

    Recent education reform in China reflects the global trend of education policy borrowing from Anglophone countries such as the USA. The reform in China essentially advocates shifting from knowledge reproduction and didacticism to knowledge construction by students through a learner-centredness approach. Aware of the trend of borrowing policy from…

  17. The Orbis Cascade Merger and Its Impact on Patron-Initiated Borrowing

    Science.gov (United States)

    Munson, Doris M.; Milton, Suzanne

    2009-01-01

    In 2000, Eastern Washington University became part of the Cascade Consortium and participated in consortial borrowing through the Cascade Union Catalog. In 2003, the Orbis and Cascade consortia merged into the Orbis Cascade Alliance, which manages the Summit Union Catalog. Since 2000, Cascade or Summit consortial borrowing has increased while…

  18. Qualified to Lead? A Comparative, Contextual and Cultural View of Educational Policy Borrowing

    Science.gov (United States)

    Harris, Alma; Jones, Michelle; Adams, Donnie

    2016-01-01

    Background: Around the globe, education policy borrowing remains pervasive and prevalent. The strategies, interventions and innovations of education systems that perform well, in international assessments, are enthusiastically borrowed and copied in the anticipation of similar educational performance and outcomes. Purpose: This purpose of the…

  19. Moroccan Arabic borrowed circumfix from Berber: investigating morphological categories in a language contact situation

    Directory of Open Access Journals (Sweden)

    Georgia Zellou

    2011-12-01

    Full Text Available Moroccan Arabic (MA has a derivational noun circumfix /ta-...-t/ that is borrowed from the neighboring Berber languages. This circumfix is highly productive on native MA noun stems but not productive on borrowed Berber stems (which are rare in MA. This pattern of productivity is taken to be evidence in support of direct borrowing of morphology (c.f. Steinkruger and Seifart 2009 and against a theory where borrowed morphology enters a language as part of unanalyzed complex forms which later spread to native stems (c.f. Thomason and Kaufman 1988; Thomason 2001; furthermore, it challenges the principle of a "borrowability hierarchy" (c.f. Haugen 1950 where lexical morphemes are borrowed before grammatical morphemes. Additionally, the prefixal portion of the MA circumfix, ta-, is a complex (presumably unanalyzed form from the Berber /t-/ feminine + /a-/ absolute state. Moreover, the morpheme in MA has been borrowed as a derivational morpheme while the primary functions of the donor morphemes in Berber are inflectional. This case of a borrowed circumfix is examined as an instance which does not conform to traditional typologies of language change through contact patterns and how the boundaries between morphological categories (i.e. inflectional/derivational are transformed in a language contact situation.

  20. 22 CFR 201.62 - Responsibilities of borrower/grantee and of supplier.

    Science.gov (United States)

    2010-04-01

    ... supplier. 201.62 Section 201.62 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES.../grantee and of supplier. (a) Responsibilities of borrower/grantee. The borrower/grantee shall: (1) When... price, including transportation cost, for the commodity. (b) Responsibility of supplier. In...

  1. How Culture Matters in Educational Borrowing? Chinese Teachers' Dilemmas in a Global Era

    Science.gov (United States)

    Liu, Sheng-nan; Feng, Da-ming

    2015-01-01

    Educational borrowing may cause numerous dilemmas that emerge from cross-cultural differences among teachers in the globalization. Through the case study on the flipped classroom introduced from the United States into Chinese middle schools, this article presents an examination of dilemmas that teachers encountered during educational borrowing in…

  2. 12 CFR 617.7005 - When may electronic communications be used in the borrower rights process?

    Science.gov (United States)

    2010-01-01

    ... borrower rights process? Qualified lenders may use, with the parties' agreement, electronic commerce (E-commerce), including electronic communications for borrower rights disclosures. Part 609 of this chapter... 12 Banks and Banking 6 2010-01-01 2010-01-01 false When may electronic communications be used...

  3. 7 CFR 1781.21 - Borrower accounting methods, management, reporting, and audits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Borrower accounting methods, management, reporting... DEVELOPMENT (RCD) LOANS AND WATERSHED (WS) LOANS AND ADVANCES § 1781.21 Borrower accounting methods, management, reporting, and audits. These activities will be handled in accordance with the provisions of...

  4. 7 CFR 1942.128 - Borrower accounting methods, management reports and audits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Borrower accounting methods, management reports and audits. 1942.128 Section 1942.128 Agriculture Regulations of the Department of Agriculture (Continued... Rescue and Other Small Community Facilities Projects § 1942.128 Borrower accounting methods, management...

  5. Education Policy Borrowing in China: Has the West Wind Overpowered the East Wind?

    Science.gov (United States)

    Tan, Charlene; Chua, Catherine S. K.

    2015-01-01

    Recent education reform in China reflects the global trend of education policy borrowing from Anglophone countries such as the USA. The reform in China essentially advocates shifting from knowledge reproduction and didacticism to knowledge construction by students through a learner-centredness approach. Aware of the trend of borrowing policy from…

  6. A Step into an eco-Compatible Future: Iron- and Cobalt-catalyzed Borrowing Hydrogen Transformation.

    Science.gov (United States)

    Quintard, Adrien; Rodriguez, Jean

    2016-01-01

    Living on borrowed hydrogen: Recent developments in iron- and cobalt-catalyzed borrowing hydrogen have shown that economically reliable catalysts can be used in this type of waste-free reactions. By using well-defined inexpensive catalysts, known reactions can now be run efficiently without the necessary use of noble metals; however, in addition new types of reactivity can also be discovered.

  7. Does Discretion in Lending Increase Bank Risk? Borrower Self-Selection and Loan Officer Capture Effects

    NARCIS (Netherlands)

    Gropp, R.; Grundl, C.; Guttler, A.

    2012-01-01

    In this paper we analyze whether discretionary lending increases bank risk. We use a panel dataset of matched bank and borrower data. It offers the chief advantages that we can directly identify soft information in banks’ lending decisions and that we observe ex post defaults of borrowers.Consistent

  8. Does Discretion in Lending Increase Bank Risk? Borrower Self-Selection and Loan Officer Capture Effects

    NARCIS (Netherlands)

    Gropp, R.; Grundl, C.; Guttler, A.

    2012-01-01

    Abstract: In this paper we analyze whether discretionary lending increases bank risk. We use a panel dataset of matched bank and borrower data. It offers the chief advantages that we can directly identify soft information in banks’ lending decisions and that we observe ex post defaults of borrowers.

  9. 13 CFR 123.506 - How much can you borrow under the Military Reservist EIDL Program?

    Science.gov (United States)

    2010-01-01

    ... Military Reservist EIDL Program? 123.506 Section 123.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Military Reservist Economic Injury Disaster Loans § 123.506 How much can you borrow under the Military Reservist EIDL Program? You can borrow an amount equal to the...

  10. Reciprocal Cross-School Attraction in Domestic Educational Policy Borrowing: An Initial Conceptualization

    Science.gov (United States)

    Barmeier, Henry

    2012-01-01

    This article presents a novel theoretical framework for the study of educational policy borrowing at the sub-national level. Prior theorizing on educational policy transfer, and on policy "borrowing" in particular, has focused on cross-national processes. In this article the author uses the existing cross-national models of Phillips and…

  11. Borrowing Strength with Non-Exchangeable Priors over Subpopulations

    Science.gov (United States)

    Leon-Novelo, L.G.; Bekele, B. Nebiyou; Müller, P.; Quintana, F.; Wathen, K.

    2017-01-01

    Summary We introduce a non-parametric Bayesian model for a phase II clinical trial with patients presenting different subtypes of the disease under study. The objective is to estimate the success probability of an experimental therapy for each subtype. We consider the case when small sample sizes require extensive borrowing of information across subtypes, but the subtypes are not a priori exchangeable. The lack of a priori exchangeability hinders the straightforward use of traditional hierarchical models to implement borrowing of strength across disease subtypes. We introduce instead a random partition model for the set of disease subtypes. This is a variation of the product partition model that allows us to model a non-exchangeable prior structure. Like a hierarchical model, the proposed clustering approach considers all observations, across all disease subtypes, to estimate individual success probabilities. But in contrast to standard hierarchical models, the model considers disease subtypes a priori non-exchangeable. This implies that when assessing the success probability for a particular type our model borrows more information from the outcome of the patients sharing the same prognosis than from the others. Our data arises from a phase II clinical trial of patients with sarcoma, a rare type of cancer affecting connective or supportive tissues and soft tissue (e.g., cartilage and fat). Each patient presents one subtype of the disease and subtypes are grouped by good, intermediate, and poor prognosis. The prior model should respect the varying prognosis across disease subtypes. The practical motivation for the proposed approach is that the number of accrued patients within each disease subtype is small. Thus it is not possible to carry out a clinical study of possible new therapies for rare conditions, because it would be impossible to plan for sufficiently large sample size to achieve the desired power. We carry out a simulation study to compare the proposed

  12. Understanding Indonesian People Borrowing Money from Banks and Non-Banking Institutions

    Directory of Open Access Journals (Sweden)

    Roro Hindun

    2016-12-01

    Full Text Available People’s borrowing behaviours are influenced by the need to fulfil their basic needs which always change in maintaining their lifestyles. This thesis analyzes the tendency of Indonesians to borrowing money, either from banks or non-banking institutions. This research was carried out using quantitative data analysis with secondary data from the Indonesian Family Life Survey panel data versions 3 and 4. The data was analyzed using STATA 12.0 software. The results of the study show that the significant factors that affect people’s behaviour in borrowing from either banks or non-banking institutions are amount of debt, assets, income, and location; while the insignificant factors are age, religion, and number of householders.   Keywords: money borrowing, borrowing behaviour, debt, IFLS, STATA

  13. Environmental impacts of phosphogypsum vs. borrow pits in roadfill construction.

    Science.gov (United States)

    Martin, D F; Dooris, P M; Sumpter, D

    2001-01-01

    A comparison was performed of the environmental impacts of using phosphogypsum versus conventional fill materials (e.g., from borrow pits) for road construction. The study compared a hypothetical roadway with an actual roadway in Florida; the two facilities differed only in that phosphogypsum was employed as fill material instead of conventional materials. The effect of the two construction approaches on the plant and animal communities was considered, as was the impact on the surface and ground water. A summary was made of the comparative impacts, and a comparison matrix was constructed using integral numbers to depict impacts ranging from -5 (most impact) to 0 (none) to + 5, showing most benefit of the part of the project on a given resource. Values were subjective, based upon investigators' experience. Four categories (plant and animal communities, water quality, water resources, and air quality) were considered. The cumulative total was +12 for phosphogypsum and -6 for conventional fill material.

  14. Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells.

    Science.gov (United States)

    Verderio, Paolo; Pandolfi, Laura; Mazzucchelli, Serena; Marinozzi, Maria Rosaria; Vanna, Renzo; Gramatica, Furio; Corsi, Fabio; Colombo, Miriam; Morasso, Carlo; Prosperi, Davide

    2014-08-04

    Among polymeric nanoparticles designed for cancer therapy, PLGA nanoparticles have become one of the most popular polymeric devices for chemotherapeutic-based nanoformulations against several kinds of malignant diseases. Promising properties, including long-circulation time, enhanced tumor localization, interference with "multidrug" resistance effects, and environmental biodegradability, often result in an improvement of the drug bioavailability and effectiveness. In the present work, we have synthesized 1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one (ASC-J9) and developed uniform ASC-J9-loaded PLGA nanoparticles of about 120 nm, which have been prepared by a single-emulsion process. Structural and morphological features of the nanoformulation were analyzed, followed by an accurate evaluation of the in vitro drug release kinetics, which exhibited Fickian law diffusion over 10 days. The intracellular degradation of ASC-J9-bearing nanoparticles within estrogen-dependent MCF-7 breast cancer cells was correlated to a time- and dose-dependent activity of the released drug. A cellular growth inhibition associated with a specific cell cycle G2/M blocking effect caused by ASC-J9 release inside the cytosol allowed us to put forward a hypothesis on the action mechanism of this nanosystem, which led to the final cell apoptosis. Our study was accomplished using Annexin V-based cell death analysis, MTT assessment of proliferation, radical scavenging activity, and intracellular ROS evaluation. Moreover, the intracellular localization of nanoformulated ASC-J9 was confirmed by a Raman optical imaging experiment designed ad hoc. PLGA nanoparticles and ASC-J9 proved also to be safe for a healthy embryo fibroblast cell line (3T3-L1), suggesting a possible clinical translation of this potential nanochemotherapeutic to expand the inherently poor bioavailability of hydrophobic ASC-J9 that could be proposed for the treatment of malignant breast cancer.

  15. 34 CFR 682.412 - Consequences of the failure of a borrower or student to establish eligibility.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Consequences of the failure of a borrower or student to... § 682.412 Consequences of the failure of a borrower or student to establish eligibility. (a) The lender... borrowed, without the lender or school's knowledge at the time the loan was made, provided false...

  16. Optimizing the ASC WAN: evaluating network performance tools for comparing transport protocols.

    Energy Technology Data Exchange (ETDEWEB)

    Lydick, Christopher L.

    2007-07-01

    The Advanced Simulation & Computing Wide Area Network (ASC WAN), which is a high delay-bandwidth network connection between US Department of Energy National Laboratories, is constantly being examined and evaluated for efficiency. One of the current transport-layer protocols which is used, TCP, was developed for traffic demands which are different from that on the ASC WAN. The Stream Control Transport Protocol (SCTP), on the other hand, has shown characteristics which make it more appealing to networks such as these. Most important, before considering a replacement for TCP on any network, a testing tool that performs well against certain criteria needs to be found. In order to try to find such a tool, two popular networking tools (Netperf v.2.4.3 & v.2.4.6 (OpenSS7 STREAMS), and Iperf v.2.0.6) were tested. These tools implement both TCP and SCTP and were evaluated using four metrics: (1) How effectively can the tool reach a throughput near the bandwidth? (2) How much of the CPU does the tool utilize during operation? (3) Is the tool freely and widely available? And, (4) Is the tool actively developed? Following the analysis of those tools, this paper goes further into explaining some recommendations and ideas for future work.

  17. University of Utah ASC site review. August 24-25, 2006

    Energy Technology Data Exchange (ETDEWEB)

    Hertel, Eugene S., Jr. (.,; .)

    2007-02-01

    This report is a review of progress made by the Center for the Simulation of Accidental Fires and Explosions (C-SAFE) at the University of Utah, during the ninth year (Fiscal 2006) of its existence as an activity funded by the Department of Energy's Advanced Simulation and Computing Program (ASC). The ten-member Review Team composed of the TST and AST spent two days (August 24-25, 2006) at the University, reviewing formal presentations and demonstrations by the C-SAFE researchers and conferring privately. The Review Team found that the C-SAFE project administrators and staff had prepared well for the review. C-SAFE management and staff openly shared extensive answers to unexpected questions and the advance materials were well prepared and very informative. We believe that the time devoted to the review was used effectively and hope that the recommendations included in this 2006 report will provide helpful guidance to C-SAFE personnel and ASC managers.

  18. Aeroacoustics research in Europe: The CEAS-ASC report on 2014 highlights

    Science.gov (United States)

    Detandt, Yves

    2015-11-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. Each year the committee highlights some of the research and development projects in Europe. This paper is the 2014 issue of this collection of Aeroacoustic Highlights, compiled from informations submitted to the CEAS-ASC. The contributions are classified in different topics; the first categories being related to specific aeroacoustic challenges (airframe noise, fan and jet noise, helicopter noise, aircraft interior noise) and two last sections are respectively devoted to recent improvements and emerging techniques and to general advances in aeroacoustics. For each section, the present paper focus on accomplished projects, providing the state of the art in each research category in 2014. A number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights funded by national programmes or by industry.

  19. Comparison of lysimeter based and calculated ASCE reference evapotranspiration in a subhumid climate

    Science.gov (United States)

    Nolz, Reinhard; Cepuder, Peter; Eitzinger, Josef

    2016-04-01

    The standardized form of the well-known FAO Penman-Monteith equation, published by the Environmental and Water Resources Institute of the American Society of Civil Engineers (ASCE-EWRI), is recommended as a standard procedure for calculating reference evapotranspiration (ET ref) and subsequently plant water requirements. Applied and validated under different climatic conditions it generally achieved good results compared to other methods. However, several studies documented deviations between measured and calculated reference evapotranspiration depending on environmental and weather conditions. Therefore, it seems generally advisable to evaluate the model under local environmental conditions. In this study, reference evapotranspiration was determined at a subhumid site in northeastern Austria from 2005 to 2010 using a large weighing lysimeter (ET lys). The measured data were compared with ET ref calculations. Daily values differed slightly during a year, at which ET ref was generally overestimated at small values, whereas it was rather underestimated when ET was large, which is supported also by other studies. In our case, advection of sensible heat proved to have an impact, but it could not explain the differences exclusively. Obviously, there were also other influences, such as seasonal varying surface resistance or albedo. Generally, the ASCE-EWRI equation for daily time steps performed best at average weather conditions. The outcomes should help to correctly interpret ET ref data in the region and in similar environments and improve knowledge on the dynamics of influencing factors causing deviations.

  20. U.S. Dental School Deans’ Perceptions of the Rising Cost of Dental Education and Borrowing Pressures on Dental Students: Report of Survey Results.

    Science.gov (United States)

    McAllister, Dora Elías; Garrison, Gwen E; Feldman, Cecile A; Anderson, Eugene L; Cook, Bryan J; Valachovic, Richard W

    2015-06-01

    This report presents findings from a survey of U.S. dental school deans designed to capture their perceptions regarding the rising cost of dental education and its impact on borrowing by dental students to finance their education. The survey included questions about factors influencing the cost of dental education, concerns about dental student borrowing, and financial awareness resources for students. The survey was distributed to the deans of all 63 U.S. dental schools in January 2013; 42 deans responded, for a 67% response rate. The results indicate that, according to the responding deans, new clinical technologies, technology costs, and central university taxes are the main factors that contribute to the increasing cost of dental education. Coupled with reduced state appropriations at public dental schools and declines in private giving at all dental schools, dental school deans face a perplexing set of financial management challenges. Tuition and fees are a primary source of revenue for all dental schools; however, many deans do not have total control over the cost of attending their schools since tuition and fees are often tied to mandates and policies from the parent university and the state legislature. The findings of this study indicate that U.S. dental school deans are aware of and concerned about the impact of increases in tuition and fees on dental student debt and that they are using a variety of strategies to address the growth in dental student borrowing.

  1. The role of colposcopy and typization of human papillomavirus in further diagnostic proceedings in patients with ASC-US cytological finding of the uterine cervix

    Directory of Open Access Journals (Sweden)

    Živadinović Radomir

    2009-01-01

    Full Text Available Background/Aim. Bethesda system of classification of cytological findings was introduced in 2001 two subcategories in the category of atypical squamous cells (ASC findings: ASC of undetermined significance (ASC-US and ASC which cannot exclude high-grade intraepithelial lesions (ASC-H. The aim of our study was to assess a possible association of these two subcategories with pathologic biopsy finding and to find out the best further diagnostic proceedings. Methods. At the Clinic of Gynecology and Obstetrics, Niš 130 patients with ASC findings were analyzed. Colposcopy was performed in all study participants. Patients with pathological colposcopic findings underwent cervical biopsy. In 10 patients with pathologic histologic and 15 with benign findings human papilloma virus (HPV typization was done using the Hybrid Capture method. Results. Patients with ASC-H finding had significantly more pathologic biopsies compared with patients with ASC-US finding (57.84: 20.72. Conclusion. Colposcopy was exhibited somewhat higher sensitivity compared to HPV typization (94.7 : 90, but lower sensitivity (79.27 : 86.6. The usage of HPV typization in the triage of patients with ASC cytologic smear induces statistically significant reduction of unnecessary percentage of cervical biopsies.

  2. Atypical squamous cells, cannot exclude high grade squamous intraepithelial (ASC-H in HIV-positive women

    Directory of Open Access Journals (Sweden)

    Michelow Pam

    2010-01-01

    Full Text Available Objective: South Africa has very high rates of both HIV infection and cervical pathology. The management of ASC-H is colposcopy and directed biopsy, but with so many women diagnosed with HSIL and a dearth of colposcopy centres in South Africa, women with cytologic diagnosis of ASC-H may not be prioritized for colposcopy. The aim of this study was to determine if HIV-positive women with a cytologic diagnosis of ASC-H should undergo immediate colposcopy or whether colposcopy can be delayed, within the context of an underfunded health care setting with so many competing health needs. Materials and Methods: A computer database search was performed from the archives of an NGO-administered clinic that offers comprehensive HIV care. All women with a cytologic diagnosis of ASC-H on cervical smears from September 2005 until August 2009 were identified. Histologic follow up was sought in all patients. Results: A total of 2111 cervical smears were performed and 41 diagnosed as ASC-H (1.94%. No histologic follow up data was available in 15 cases. Follow up histologic results were as follows: three negative (11.5%, five koilocytosis and/ or CIN1 (19.2%, ten CIN2 (38.5% and eight CIN3 (30.8%. There were no cases of invasive carcinoma on follow up. Conclusion: The current appropriate management of HIV-positive women in low-resource settings with a diagnosis of ASC-H on cervical smear is colposcopy, despite the costs involved. In the future and if cost-effective in developing nations, use of novel markers may help select which HIV-positive women can be managed conservatively and which ones referred for more active treatment. More research in this regard is warranted.

  3. Ouateres ou veces? Emprunt ou etymologie? ("Ouateres" or "Veces"? Borrowing or Etymology?).

    Science.gov (United States)

    Calvet, Louis-Jean

    1989-01-01

    The variety of terms used by different cultures for bathroom facilities not only illustrates the problems language poses for travelers but also opens a discussion of the distinction between linguistic borrowing and etymology. (MSE)

  4. Federal Outer Continental Shelf (OCS) Sand and Gravel Borrow Areas (Lease Areas)

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — Federal outer Continental Shelf (OCS) Sand and Gravel Borrow Areas (Lease Areas) are polygons which are maintained by the Bureau of Ocean Energy Management (BOEM),...

  5. On lexical borrowings from the Catalan, Galician and Basque languages in Spanish political speech

    Directory of Open Access Journals (Sweden)

    А О Уржумцева

    2009-06-01

    Full Text Available The article explores and classifies Spanish borrowings (such as certain toponyms, anthroponyms, and precedent text fragments from official provincial languages of Spain (Catalan, Galician, Basque in political speech of this country.

  6. 7 CFR 1724.70 - Standard forms of contracts for borrowers.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND... construction, procurement, engineering services, and architectural services financed by a loan made or... required to use in the planning, design, and construction of their electric systems. Borrowers are...

  7. Open Technology Development: Roadmap Plan

    Science.gov (United States)

    2006-04-01

    Linux Apache MySql (PHP/ Perl /Python) integrated services. This standardized "stack" of open source technologies enables robust web based information...ACTD Office • Sue Payton, AS&C Office • LTG Robert M. Shea, Joint Staff, J-6 • David Scantling, OSD, Business Transformation Office • Fritz

  8. Post-processing V&V level II ASC milestone (2360) results.

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Elmer; Karelitz, David B.; Brunner, Thomas A.; Trucano, Timothy Guy; Moreland, Kenneth D.; Weirs, V. Gregory; Shead, Timothy M.

    2007-09-01

    The 9/30/2007 ASC Level 2 Post-Processing V&V Milestone (Milestone 2360) contains functionality required by the user community for certain verification and validation tasks. These capabilities include loading of edge and face data on an Exodus mesh, run-time computation of an exact solution to a verification problem, delivery of results data from the server to the client, computation of an integral-based error metric, simultaneous loading of simulation and test data, and comparison of that data using visual and quantitative methods. The capabilities were tested extensively by performing a typical ALEGRA HEDP verification task. In addition, a number of stretch criteria were met including completion of a verification task on a 13 million element mesh.

  9. Sliding and Rocking of Unanchored Components and Structures: Chapter 7.6 ASCE 4 Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    S. R. Jensen

    2011-04-01

    Chapter 7.6 of ASCE 4-Rev 2, Seismic Analysis of Safety-Related Nuclear Structures: Standard and Commentary, provides updated guidance for analysis of rocking and sliding of unanchored structures and components subjected to seismic load. This guidance includes provisions both for simplified approximate energy-based approaches, and for detailed probabilistic time history analysis using nonlinear methods. Factors to be applied to the analytical results are also provided with the intent of ensuring achievement of the 80% non-exceedence probability target of the standard. The present paper surveys the published literature supporting these provisions. The results of available testing and analysis are compared to results produced by both simplified and probabilistic approaches. In addition, adequacy of the standard's provisions for analysis methods and factors is assessed. A comparison is made between the achieved level of conservatism and the standard's non-exceedence probability target.

  10. Evaluation and Validation of Organic Materials for Advanced Stirling Convertors (ASCs): Overview

    Science.gov (United States)

    Shin, Euy-Sik Eugene

    2015-01-01

    Various organic materials are used as essential parts in Stirling Convertors for their unique properties and functionalities such as bonding, potting, sealing, thread locking, insulation, and lubrication. More efficient Advanced Stirling Convertors (ASC) are being developed for future space applications especially with a long mission cycle, sometimes up to 17 years, such as deep space exploration or lunar surface power or Mars rovers, and others. Thus, performance, durability, and reliability of those organics should be critically evaluated in every possible material-process-fabrication-service environment relations based on their mission specifications. In general, thermal stability, radiation hardness, outgassing, and material compatibility of the selected organics have been systematically evaluated while their process and fabrication conditions and procedures were being optimized. Service environment-simulated long term aging tests up to 4 years were performed as a function of temperature for durability assessment of the most critical organic material systems.

  11. The Cost of Collateralized Borrowing in the Colombian Money Market: Does Connectedness Matter?

    OpenAIRE

    Constanza Martínez; Carlos León

    2014-01-01

    Under the view that the market is a weighted and directed network (Barabási, 2003), this document is a first attempt to model the Colombian money market within a spatial econometrics framework. By estimating two standard spatial econometric models, we study the cost of collateralized borrowing (i.e. sell/buy backs) among Colombian financial institutions, and its relationship with the effects induced by traditional variables (leverage, size and borrowing levels), and by spatial variables resul...

  12. Economic analysis of technological innovations to improve sustainability of pangasius production in Vietnam

    NARCIS (Netherlands)

    Ngoc, Pham Thi Anh

    2016-01-01

    In response to increasing concerns about sustainable production, a growing number of European customers expect seafood products to be certified, for example by the Aquaculture Stewardship Council (ASC) certification. Water purification technologies such as Recirculating Aquaculture Systems (RAS) cou

  13. Economic analysis of technological innovations to improve sustainability of pangasius production in Vietnam

    NARCIS (Netherlands)

    Ngoc, Pham Thi Anh

    2016-01-01

    In response to increasing concerns about sustainable production, a growing number of European customers expect seafood products to be certified, for example by the Aquaculture Stewardship Council (ASC) certification. Water purification technologies such as Recirculating Aquaculture Systems (RAS) cou

  14. Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

    Science.gov (United States)

    Lee, Hye Eun; Yang, Gabsik; Kim, Nam Doo; Jeong, Seongkeun; Jung, Yunjin; Choi, Jae Young; Park, Hyun Ho; Lee, Joo Young

    2016-01-01

    Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of various metabolic diseases including gouty arthritis. We investigated whether an orally administrable inhibitor of NLRP3 inflammasome was effective for alleviating the pathological symptoms of gouty arthritis and what was the underlying mechanism. In primary mouse macrophages, caffeic acid phenethyl ester(CAPE) blocked caspase-1 activation and IL-1β production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation. In mouse gouty arthritis models, oral administration of CAPE suppressed MSU crystals-induced caspase-1 activation and IL-1β production in the air pouch exudates and the foot tissues, correlating with attenuation of inflammatory symptoms. CAPE directly associated with ASC as shown by SPR analysis and co-precipitation, resulting in blockade of NLRP3-ASC interaction induced by MSU crystals. Our findings provide a novel regulatory mechanism by which small molecules harness the activation of NLRP3 inflammasome by presenting ASC as a new target. Furthermore, the results suggest the preventive or therapeutic strategy for NLRP3-related inflammatory diseases such as gouty arthritis using orally available small molecules. PMID:27934918

  15. To treat or not to treat; the clinical dilemma of atypical squamous cells of undetermined significance (ASC-US)

    NARCIS (Netherlands)

    Bie, R.P. de; Massuger, L.F.A.G.; Dongen, R.A. van; Snijders, M.P.; Bulten, J.; Melchers, W.J.G.; Bekkers, R.L.M.

    2011-01-01

    OBJECTIVE: Management of patients diagnosed on cervical smears with twice consecutively atypical squamous cells of undetermined significance (ASC-US) remains a clinical dilemma. We describe a follow-up of aggressive vs. less aggressive colposcopic treatment in order to determine which treatment is p

  16. The Asc locus for resistance to Alternaria stem canker in tomato does not encode the enzyme aspartate carbamoyltransferase

    NARCIS (Netherlands)

    Overduin, Bert; Hogenhout, Saskia A.; Biezen, Erik A. van der; Haring, Michel A.; Nijkamp, H. John J.; Hille, Jacques

    1993-01-01

    The fungal disease resistance locus Alternaria stem canker (Asc) in tomato has been suggested to encode the enzyme aspartate carbamoyltransferase (ACTase). To test this hypothesis a segment of the tomato ACTase gene was amplified by the polymerase chain reaction (PCR) using degenerate primers. The P

  17. Molecular genetic characterisation of the Asc locus of tomato conferring resistance to the fungal pathogen Alternaria alternata f. sp. lycopersici

    NARCIS (Netherlands)

    Biezen, E.A. van der; Overduin, B.; Kneppers, T.J.A.; Mesbah, L.A.; Nijkamp, H.J.J.; Hille, J.

    1994-01-01

    The Alternaria stem canker disease of tomato is caused by the fungal pathogen Alternaria alternata f. sp. lycopersici and its host-selective AAL-toxins. Resistance to the pathogen and insensitivity to the toxins are conferred by the Asc locus on chromosome 3L. Sensitivity to AAL-toxins is a relative

  18. Human adipose stromal cells (ASC for the regeneration of injured cartilage display genetic stability after in vitro culture expansion.

    Directory of Open Access Journals (Sweden)

    Simona Neri

    Full Text Available Mesenchymal stromal cells are emerging as an extremely promising therapeutic agent for tissue regeneration due to their multi-potency, immune-modulation and secretome activities, but safety remains one of the main concerns, particularly when in vitro manipulation, such as cell expansion, is performed before clinical application. Indeed, it is well documented that in vitro expansion reduces replicative potential and some multi-potency and promotes cell senescence. Furthermore, during in vitro aging there is a decrease in DNA synthesis and repair efficiency thus leading to DNA damage accumulation and possibly inducing genomic instability. The European Research Project ADIPOA aims at validating an innovative cell-based therapy where autologous adipose stromal cells (ASCs are injected in the diseased articulation to activate regeneration of the cartilage. The primary objective of this paper was to assess the safety of cultured ASCs. The maintenance of genetic integrity was evaluated during in vitro culture by karyotype and microsatellite instability analysis. In addition, RT-PCR array-based evaluation of the expression of genes related to DNA damage signaling pathways was performed. Finally, the senescence and replicative potential of cultured cells was evaluated by telomere length and telomerase activity assessment, whereas anchorage-independent clone development was tested in vitro by soft agar growth. We found that cultured ASCs do not show genetic alterations and replicative senescence during the period of observation, nor anchorage-independent growth, supporting an argument for the safety of ASCs for clinical use.

  19. Expressions of ASC and caspase-1 but not AIM2 are disrupted in chronic HBV infected patients

    Directory of Open Access Journals (Sweden)

    Gholamhossein Hassanshahi

    2014-08-01

    Full Text Available Objective: To determine the mRNA levels of absent in melanoma 2 (AIM2, apoptosis-associated speck like protein containing a caspase recruitment domain (ASC and caspase-1 in the peripheral blood mononuclear cells of chronic hepatitis B virus (CHB infected patients. Methods: This study was conducted on 60 CHB patients and 60 healthy controls and the mRNA levels of AIM2, ASC and caspase-1 were examined in parallel with beta-actin (as housekeeping gene using real-time polymerase chain reaction technique. Results: Our results indicated that expression of ASC and caspase-1 but not AIM2 were significantly decreased in peripheral blood mononuclear cells isolated from CHB patients compared to healthy controls. Conclusions: According to our results, it is likely that CHB patients are unable to firmly express ASC and caspase-1 genes and in turn properly activate IL1β and IL-18 subsequent to hepatitis B virus infection. Thus, these results propose a mechanism which almost partially may describe a reasonable fact that why the infection is sustained in the CHB patients.

  20. Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.

    Science.gov (United States)

    Lee, Hye Eun; Yang, Gabsik; Kim, Nam Doo; Jeong, Seongkeun; Jung, Yunjin; Choi, Jae Young; Park, Hyun Ho; Lee, Joo Young

    2016-12-09

    Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of various metabolic diseases including gouty arthritis. We investigated whether an orally administrable inhibitor of NLRP3 inflammasome was effective for alleviating the pathological symptoms of gouty arthritis and what was the underlying mechanism. In primary mouse macrophages, caffeic acid phenethyl ester(CAPE) blocked caspase-1 activation and IL-1β production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation. In mouse gouty arthritis models, oral administration of CAPE suppressed MSU crystals-induced caspase-1 activation and IL-1β production in the air pouch exudates and the foot tissues, correlating with attenuation of inflammatory symptoms. CAPE directly associated with ASC as shown by SPR analysis and co-precipitation, resulting in blockade of NLRP3-ASC interaction induced by MSU crystals. Our findings provide a novel regulatory mechanism by which small molecules harness the activation of NLRP3 inflammasome by presenting ASC as a new target. Furthermore, the results suggest the preventive or therapeutic strategy for NLRP3-related inflammatory diseases such as gouty arthritis using orally available small molecules.

  1. Genetic and physical analysis of a YAC contig spanning the fungal disease resistance locus Asc of tomato (Lycopersicon esculentum)

    NARCIS (Netherlands)

    Mesbah, L.A.; Kneppers, T.J.A.; Takken, F.L.W.; Laurent, P.; Hille, J.; Nijkamp, H.J.J.

    1998-01-01

    The Alternaria stem canker disease of tomato is caused by the necrotrophic fungal pathogen Alternaria alternata f. sp. lycopersici (AAL). The fungus produces AAL toxins that kill the plant tissue. Resistance to the fungus segregates as a single locus, called Asc, and has been genetically mapped on c

  2. 42 CFR 413.118 - Payment for facility services related to covered ASC surgical procedures performed in hospitals...

    Science.gov (United States)

    2010-10-01

    ... ASC surgical procedures performed in hospitals on an outpatient basis. 413.118 Section 413.118 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING FACILITIES Specific Categories of Costs §...

  3. To treat or not to treat; the clinical dilemma of atypical squamous cells of undetermined significance (ASC-US)

    NARCIS (Netherlands)

    Bie, R.P. de; Massuger, L.F.A.G.; Dongen, R.A. van; Snijders, M.P.; Bulten, J.; Melchers, W.J.G.; Bekkers, R.L.M.

    2011-01-01

    OBJECTIVE: Management of patients diagnosed on cervical smears with twice consecutively atypical squamous cells of undetermined significance (ASC-US) remains a clinical dilemma. We describe a follow-up of aggressive vs. less aggressive colposcopic treatment in order to determine which treatment is p

  4. Lexical Borrowing in the Qur’ān

    Directory of Open Access Journals (Sweden)

    Catherine Pennacchio

    2012-04-01

    Full Text Available The last study offering an exhaustive presentation of loanwords in the Qur’ān is Arthur Jeffery’s The Foreign Vocabulary of the Qur’ān (1938. This lexicon comprises the 275 foreign words (not including proper nouns found in the Qur’ān. It compiles previous studies dealing with lexical borrowing – a topic at the heart of the Oriental research in an era when it focused on the origins of Islam. The quantity of sources mentioned in Jeffery’s study was somewhat detrimental: throughout the past century, The Foreign Vocabulary of the Qur’ān was considered a conclusive work whereas the author’s intention simply was to collect everything written on the subject. It was meant to be a starting point for further studies but no additional research was undertaken in the field. Though outdated, these studies cannot be ignored. This article examines the problematic aspects of Jeffery’s work. The list and the hypotheses on the origins of the loanwords need to be revised and updated along two lines: first, they need to include new linguistic knowledge, in particular in Ugaritic and in North Arabian and South Arabian epigraphy, which was in its early stages in 1938; second, they need to be placed in their political and socio-cultural contexts. This renewal in research is important since the loanwords in the Qur’ān constitute the historical traces of the ancient contacts between the Arab populations and their neighbors. These loanwords contribute to a better understanding of the Qur’ānic text and, generally, of the beginnings of the Arabic language.

  5. Chestnut Ridge Borrow Area Waste Pile work plan

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R. (Oak Ridge Y-12 Plant, TN (United States))

    1991-08-01

    The US Department of Energy (DOE), through its contractor Martin Marietta Energy Systems, Inc., has constructed a storage facility, the Chestnut Ridge Borrow Area Waste Pile (CRBAWP), for mercury-contaminated soil excavated from the Oak Ridge Civic Center properties and the Oak Ridge Sewer Line Beltway. Excavation of the soil from the Civic Center began in September 1984 and was completed in early 1985. Similar soils from other areas of the city were added to the pile until 1987. Approximately 3000 yd{sup 3} are stored at the present time. An Interim Status RCRA permit was initially sought for this facility. Samples from the waste pile passed the Extraction Procedure Toxicity Test (EP Tox). The Tennessee Department of Health and Environment (now the Tennessee Department of Conservation-TDC) denied the permit based on their conclusion that the waste was not a RCRA-regulated waste. On September 25, 1990 the Toxicity Characteristic Leaching Procedure (TCLP) superseded the EP Tox test. TCLP tests are not proposed to satisfy a request by TDC and to make a final determination of the nature of the soils in order to close the CRBAWP as a solid waste disposal facility under Tennessee State rule 1200-1-7-.04. The objectives of this work are to summarize existing site information and detail actions necessary to sample and characterize soils from the waste pile as hazardous or nonhazardous per the Toxicity Characteristic Leaching Procedure (TCLP). Within the scope of this plan, a site investigation will be discussed; a field sampling plan will be described in terms of sampling locations, procedures, and quality assurance; and ancillary activities such as waste management, data management, and health and safety will be outlines. 15 refs., 7 figs., 2 tabs.

  6. ASC provides a potential link between depression and inflammatory disorders: A clinical study of depressed Iranian medical students.

    Science.gov (United States)

    Momeni, Mohammad; Ghorban, Khodayar; Dadmanesh, Maryam; Khodadadi, Hassan; Bidaki, Reza; Kazemi Arababadi, Mohammad; Kennedy, Derek

    2016-01-01

    Background and aims AIM2 is a component of inflammasomes which can activate caspase-1 via an adaptor protein (ASC) after pathogen-associated molecular pattern (PAMP) or danger-associated molecular pattern (DAMP) recognition. Activation of caspase-1 is a trigger for the induction of IL-1 and IL-18 which are important pro-inflammatory cytokines. Furthermore, IL-1β, which can regulate inflammatory responses, has also been associated with depression. Previous studies revealed that patients suffering from depression may also have altered immune responses, but the mechanisms underlying this correlation are unclear. Thus, the aim of this study was to determine the mRNA levels of AIM2 and ASC in the peripheral blood mononuclear cells (PBMCs) isolated from Iranian medical students suffering from depression. Materials and methods The participants used for the study included 38 Iranian medical students diagnosed with depression and 43 non-depressed students as a control group. The mRNA levels of AIM2 and ASC were evaluated by quantitative real-time polymerase chain reaction (PCR) using β-actin as a housekeeping gene for the normalization of expression. Results The results showed that mRNA levels of AIM2 were similar in both groups. However, ASC levels were significantly increased in PBMCs isolated from individuals with elevated depressive symptoms when compared to non-depressed participants. Conclusions Based on the current results, it appears that ASC transcript expression may be a surrogate marker for depression and may represent a link between depression and the altered immune responses observed in these categories of individuals with elevated depressive symptoms.

  7. Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.

    Science.gov (United States)

    Tang, Sheau-Chung; Yeh, Jih-I; Hung, Sung-Jen; Hsiao, Yu-Ping; Liu, Fu-Tong; Yang, Jen-Hung

    2016-03-01

    AHAs (α-hydroxy acids), including glycolic acid (GA), have been widely used in cosmetic products and superficial chemical peels. Inflammasome complex has been shown to play critical roles in inflammatory pathways in human keratinocytes. However, the anti-inflammatory mechanism of GA is still unknown. The aim of this study is to investigate the relationship between the expression of the inflammasome complex and epigenetic modification to elucidate the molecular mechanism of the anti-inflammatory effect of GA in HaCaT cells. We evaluated NLRP3, NLRC4, AIM2, and ASC inflammasome complex gene expression on real-time polymerase chain reaction (PCR). Methylation changes were detected in these genes following treatment with DNA methyltransferase (DNMT) inhibitor 5-aza-2'-deoxycytidine (5-Aza) with or without the addition of GA using methylation-specific PCR (MSP). GA inhibited the expressions of these inflammasome complex genes, and the decreases in the expressions of mRNA were reversed by 5-Aza treatment. Methylation was detected in NLRC4 and ASC on MSP, but not in NLRP3 or AIM2. GA decreased NLRC4 and ASC gene expression by increasing not only DNA methyltransferase 3B (DNMT-3B) protein level, but also total DNMT activity. Furthermore, silencing of DNMT-3B (shDNMT-3B) increased the expressions of NLRC4 and ASC. Our data demonstrated that GA treatment induces hypermethylation of promoters of NLRC4 and ASC genes, which may subsequently lead to the hindering of the assembly of the inflammasome complex in HaCaT cells. These results highlight the anti-inflammatory potential of GA-containing cosmetic agents in human skin cells and demonstrate for the first time the role of aberrant hypermethylation in this process.

  8. Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns.

    Science.gov (United States)

    Nalbantoglu, S; Tanyolac, B; Berdeli, A

    2013-01-01

    The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of the most common autoinflammatory disorder, familial Mediterranean fever (FMF). Pyrin, the protein product of the FMF gene MEFV, interacts with the inflammasome complex adaptor protein ASC/PYCARD (apoptosis-associated speck-like protein with a CARD). Pyrin and ASC can both function as either inducers or suppressors of the cellular inflammatory response. We aimed to characterize ASC-induced gene expression profiles in FMF patients with different MEFV mutation patterns. A total of 165 Caucasian patients with clinical and molecular FMF diagnoses were enrolled in the study. ASC gene expression was quantified by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). ASC mRNA expression was increased in the MEFV mutation-positive group compared to the mutation-negative group (p = 0.001). The fold changes of ASC expression in the M694V homozygous (p = 0.02), M694V heterozygous (p = 0.012), compound heterozygous (p = 0.002), and R202Q/P369S/R408Q (p = 0.00) groups relative to the MEFV mutation-negative group were +2.4, +2.7, +3, and +3.4, respectively. qRT-PCR did not reveal a significant difference in ASC mRNA expression levels among the MEFV mutation-positive groups (p > 0.05). ASC mRNA expression was up-regulated in patients carrying MEFV mutations independent of mutation type. There was no significant relationship between specific MEFV genotypes and the level of ASC expression in the patient group analysed. Thus, the findings of this work may suggest a crucial relationship between mutant MEFV/pyrin and remarkable ASC up-regulation in FMF inflammation.

  9. Borrowing of strength and study weights in multivariate and network meta-analysis.

    Science.gov (United States)

    Jackson, Dan; White, Ian R; Price, Malcolm; Copas, John; Riley, Richard D

    2015-11-06

    Multivariate and network meta-analysis have the potential for the estimated mean of one effect to borrow strength from the data on other effects of interest. The extent of this borrowing of strength is usually assessed informally. We present new mathematical definitions of 'borrowing of strength'. Our main proposal is based on a decomposition of the score statistic, which we show can be interpreted as comparing the precision of estimates from the multivariate and univariate models. Our definition of borrowing of strength therefore emulates the usual informal assessment. We also derive a method for calculating study weights, which we embed into the same framework as our borrowing of strength statistics, so that percentage study weights can accompany the results from multivariate and network meta-analyses as they do in conventional univariate meta-analyses. Our proposals are illustrated using three meta-analyses involving correlated effects for multiple outcomes, multiple risk factor associations and multiple treatments (network meta-analysis). © The Author(s) 2015.

  10. Syntheses, structure and intercalation properties of low-dimensional phenylarsonates, A(HO3AsC6H5)(H2O3AsC6H5) (A = Tl, Na, K and Rb)

    Indian Academy of Sciences (India)

    Bonthu Krishna Kishore Reddy; K Prabhakara Rao; K Vidyasagar

    2006-01-01

    Four new low-dimensional phenylarsonates, A(HO3AsC6H5)(H2O3AsC6H5) (A = Tl(1), Na(2), K(3) and Rb(4)), have been synthesized and characterized by X-ray diffraction, spectroscopic and thermal studies. They crystallize in triclinic unit cells and have approximately planar arrangement of A+ ions, coordinated to oxygen atoms of phenylarsonates, on both sides. Structure of thallium phenylarsonate as determined by single crystal X-ray diffraction, is one-dimensional, whereas those of alkalimetal analogues are two-dimensional. Successful intercalation reactions of compounds 1 and 2 with primary -alkyl amines have been demonstrated.

  11. The Role of Wellbeing and Wellness: A Positive Psychological Model in Supporting Young People With ASCs

    Directory of Open Access Journals (Sweden)

    Irina Roncaglia

    2017-04-01

    Full Text Available In the last 10 years sport psychology expanded its applicability in a variety of fields which have helped to address some of the challenges related to high level performance and sport competition. When we talk about performance in its wider sense, sport psychology is able to help develop a better understanding on how strategies can be adopted in improving general human performance levels. This includes increasing the knowledge of key concepts such as motivation, self-confidence and resilience. Furthermore performance in its wider sense helps in the understanding of the impact of stress and arousal and how these can affect both positively and negatively performance levels including appreciating individual differences as well as dynamics between groups of individuals. In this paper performance rather than solely be related to the field of competitive or professional sport has been discussed in people with ASCs and aims to explore how by adopting a positive psychological model in the formulation of individual assessments and subsequent interventions have led to improvement in individual skills, participation, engagement and ultimately quality of life. Positive psychological principles, such as the role of wellbeing and wellness, the PERMA Model has increased our understanding of human potentials, performance and wellbeing. The aim of this paper is to present and reflect on the applicability and benefits of adopting sport psychology models, the PERMA model and positive psychological principles in special education and care settings with the presentation and discussion of their theoretical and some practical implementation in two case studies.

  12. Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.

    Science.gov (United States)

    Kumar, Mukesh; Roe, Kelsey; Orillo, Beverly; Muruve, Daniel A; Nerurkar, Vivek R; Gale, Michael; Verma, Saguna

    2013-04-01

    West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. The WNV-induced innate immune response, including production of antiviral cytokines, is critical for controlling virus infection. The adaptor protein ASC mediates a critical step in innate immune signaling by bridging the interaction between the pathogen recognition receptors and caspase 1 in inflammasome complexes, but its role in WNV immunopathogenesis is not defined. Here, we demonstrate that ASC is essential for interleukin-1β (IL-1β) production and development of effective host immunity against WNV. ASC-deficient mice exhibited increased susceptibility to WNV infection, and reduced survival was associated with enhanced virus replication in the peripheral tissues and central nervous system (CNS). Infection of cultured bone marrow-derived dendritic cells showed that ASC was essential for the activation of caspase 1, a key component of inflammasome assembly. ASC(-/-) mice exhibited attenuated levels of proinflammatory cytokines in the serum. Intriguingly, infected ASC(-/-) mice also displayed reduced levels of alpha interferon (IFN-α) and IgM in the serum, indicating the overall protective role of ASC in restricting WNV infection. However, brains from ASC(-/-) mice displayed unrestrained inflammation, including elevated levels of proinflammatory cytokines and chemokines, such as IFN-γ, CCL2, and CCL5, which correlated with more pronounced activation of the astrocytes, enhanced infiltration of peripheral immune cells in the CNS, and increased neuronal cell death. Collectively, our data provide new insights into the role of ASC as an essential modulator of inflammasome-dependent and -independent immune responses to effectively control WNV infection.

  13. First borrowing period at Ottoman Empire (1854-1876: Budget policies and consequences

    Directory of Open Access Journals (Sweden)

    Seda Ozekicioglu

    2010-10-01

    Full Text Available The financial troubles of Ottoman Empire which started in 16th century reached its ultimate point in 19th century. The Ottoman Empire searching to get rid of these troubles directed towards making some reform activities during the Tanzimat Era. Some of the money needed for these reform activities was met via the external borrowings which the Ottoman Empire had applied reluctantly and then could not preclude. During the period of 1854-1876 which was included in the Tanzimat Era and called as the first borrowing period, the Ottoman Empire signed 15 external borrowing agreements totally. However, the loans received as a result of these agreements were not used properly and then the budget deficit could not be settled. At the end of these developments, a financial bankruptcy was experienced in the Ottoman Empire in 1876.

  14. Does Consumer Confidence Forecast Household Saving and Borrowing Behavior? Evidence for Poland.

    Science.gov (United States)

    Kłopocka, Aneta Maria

    2017-01-01

    Consumer confidence plays an important role in households' decision-making processes. This study investigates the effects of consumer confidence on household saving and borrowing behavior that are unsatisfactorily considered in previous discussions. The questions of interest are first, whether indexes of consumer confidence have any predictive power on their own for future household saving and borrowing rates, and second, whether they contain information about future household saving and borrowing rates aside from the information contained in other available indicators. In addition to aggregate confidence indicators, their components are used to provide more precise information. Overall, the multiple linear regression analysis (OLS technique) of Polish time-series data gives positive answers to both questions. This finding supports the recommendation of combining the strengths of objective indicators (such as economic fundamentals) and subjective indicators (such as consumer confidence) to improve household financial behavior forecasts.

  15. How culture matters in educational borrowing? Chinese teachers’ dilemmas in a global era

    Directory of Open Access Journals (Sweden)

    Sheng-nan Liu

    2015-12-01

    Full Text Available Educational borrowing may cause numerous dilemmas that emerge from cross-cultural differences among teachers in the globalization. Through the case study on the flipped classroom introduced from the United States into Chinese middle schools, this article presents an examination of dilemmas that teachers encountered during educational borrowing in the global era. Based on the theoretical literature on cultural-historical activity theory, the study used interviews, field observations, and documents from six secondary schools in mainland China for one and a half years to understand comprehensively the dilemmas that teachers encountered when implementing the flipped classroom. The findings indicate that understandings of knowledge production, transmission, and the goal of education in mainland China differ from those in the west, which is the main reason for the teacher dilemmas. Because of the diversity in social culture, we suggest that teachers should be more culturally sensitive and improve compatibility in the process of educational borrowing.

  16. Completion Report for Multi-Site Incentive MRT 2779 Implement ASC Tripod Initiative by 30SEP08

    Energy Technology Data Exchange (ETDEWEB)

    East, D; Cerutti, J; Noe, J; Cupps, K; Loncaric, J; Sturtevant, J

    2008-09-22

    This report provides documentation and evidence for the completion of the deployment of the Tripod common operating system (TripodOS, also known as and generally referred to below as TOSS). Background documents for TOSS are provided in Appendices A and B, including the initial TOSS proposal accepted by ASC HQ and Executives in July 2007 and a Governance Model defined by a Tri-Lab working group in September 2007. Appendix C contains a document that clarifies the intent and requirements for the completion criteria associated with MRT 2779. The deployment of TOSS is a Multi-Site Incentive from the ASC FY08-09 Implementation Plan due at the end of Quarter 4 in FY08.

  17. Multifunctional nanocrystalline calcium phosphates loaded with Tetracycline antibiotic combined with human adipose derived mesenchymal stromal stem cells (hASCs).

    Science.gov (United States)

    Marycz, K; Pazik, R; Zawisza, K; Wiglusz, K; Maredziak, M; Sobierajska, P; Wiglusz, R J

    2016-12-01

    Osteoconductive drug delivery system composed of nanocrystalline calcium phosphates (Ca10(PO4)6(OH)2/β-Ca3(PO4)2) co-doped with Yb(3+)/Er(3+) ions loaded with Tetracycline antibiotic (TC) was developed. Their effect on human adipose derived mesenchymal stromal stem cells (hASCs) as a potential reconstructive biomaterial for bone tissue regeneration was studied. The XRD and TEM measurements were used in order to determine the crystal structure and morphology of the final products. The characteristics of nanocomposites with the TC and hASCs as potential regenerative materials as well as the antimicrobial activity of the nanoparticles against: Staphylococcus aureus ATCC 25923 as a model of the Gram-positive bacteria, Escherichia coli ATCC 8739 of the Gram-negative bacteria, were shown. These combinations can be a promising material for theranostic due to its regenerative, antimicrobial and fluorescent properties.

  18. Asc-1, PAT2 and P2RX5 are novel cell surface markers for white, beige and brown adipocytes

    OpenAIRE

    Ussar, Siegfried; Lee, Kevin Y.; Dankel, Simon N.; Boucher, Jeremie; Haering, Max-Felix; Kleinridders, Andre; Thomou, Thomas; Xue, Ruidan; Macotela, Yazmin; Cypess, Aaron M.; Tseng, Yu-Hua; Mellgren, Gunnar; Kahn, C. Ronald

    2014-01-01

    White, beige and brown adipocytes are developmentally and functionally distinct but often occur mixed together within individual depots. To target white, beige and brown adipocytes for diagnostic or therapeutic purposes, a better understanding of the cell surface properties of these cell types is essential. Using a combination of in silico, in vitro and in vivo methods, we have identified three new cell surface markers of adipose cell types. The amino acid transporter Asc-1 is a white adipocy...

  19. Fluorescent immortalized human adipose derived stromal cells (hASCs-TS/GFP+) for studying cell drug delivery mediated by microvesicles.

    Science.gov (United States)

    Coccè, Valentina; Balducci, Luigi; Falchetti, Maria Laura; Pascucci, Luisa; Ciusani, Emilio; Brini, Anna Teresa; Sisto, Francesca; Piovani, Giovanna; Alessandri, Giulio; Parati, Eugenio; Cabeza, Laura; Pessina, Augusto

    2017-03-27

    A new tool for the drug delivery is based on the use of Mesenchymal Stromal Cells (MSCs) loaded in vitro with anti-cancer drugs. Unfortunately, the restricted lifespan of MSCs represents a significant limitation to produce them in high amounts and for long time studies. Immortalized MSCs from adipose tissue (hASC) have been generated as good source of cells with stable features. These cells could improve the development of standardized procedures for both in vitro and preclinical studies. Furthermore they facilitate procedures for preparing large amounts of secretome containing microvesicles (MVs). We used human adipose tissue derived MSCs immortalized with hTERT+SV40 (TS) genes and transfected with GFP (hASCs-TS/GFP+). This line was investigate for its ability to uptake and release anticancer drugs. Microvesicles associated to paclitaxel (MVs/PTX) were isolated, quantified, and tested on pancreatic cancer cells. The line hASCs-TS/GFP+ maintained the main mesenchymal characters and was able to uptake and release, in active form, both paclitaxel and gemcitabine. From paclitaxel loaded hASCs-TS/GFP+ cells were isolated microvesicles in sufficient amount to inhibit "in vitro" the proliferation of pancreatic tumor cells. Our study suggests that human immortalized MSCs could be used for a large scale production of cells for mediated drug delivery. Moreover, the secretion of drug-associated MVs could represent a new way for producing new drug formulation by "biogenesis". In the context of the "advanced cell therapy procedure", the MVs/PTX production would be less resource and time consuming and it could possibly contribute to simplification of GMP procedures. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  20. ASCS online fault detection and isolation based on an improved MPCA

    Science.gov (United States)

    Peng, Jianxin; Liu, Haiou; Hu, Yuhui; Xi, Junqiang; Chen, Huiyan

    2014-09-01

    Multi-way principal component analysis (MPCA) has received considerable attention and been widely used in process monitoring. A traditional MPCA algorithm unfolds multiple batches of historical data into a two-dimensional matrix and cut the matrix along the time axis to form subspaces. However, low efficiency of subspaces and difficult fault isolation are the common disadvantages for the principal component model. This paper presents a new subspace construction method based on kernel density estimation function that can effectively reduce the storage amount of the subspace information. The MPCA model and the knowledge base are built based on the new subspace. Then, fault detection and isolation with the squared prediction error (SPE) statistic and the Hotelling ( T 2) statistic are also realized in process monitoring. When a fault occurs, fault isolation based on the SPE statistic is achieved by residual contribution analysis of different variables. For fault isolation of subspace based on the T 2 statistic, the relationship between the statistic indicator and state variables is constructed, and the constraint conditions are presented to check the validity of fault isolation. Then, to improve the robustness of fault isolation to unexpected disturbances, the statistic method is adopted to set the relation between single subspace and multiple subspaces to increase the corrective rate of fault isolation. Finally fault detection and isolation based on the improved MPCA is used to monitor the automatic shift control system (ASCS) to prove the correctness and effectiveness of the algorithm. The research proposes a new subspace construction method to reduce the required storage capacity and to prove the robustness of the principal component model, and sets the relationship between the state variables and fault detection indicators for fault isolation.

  1. ASCS Online Fault Detection and Isolation Based on an Improved MPCA

    Institute of Scientific and Technical Information of China (English)

    PENG Jianxin; LIU Haiou; HU Yuhui; XI Junqiang; CHEN Huiyan

    2014-01-01

    Multi-way principal component analysis (MPCA) has received considerable attention and been widely used in process monitoring. A traditional MPCA algorithm unfolds multiple batches of historical data into a two-dimensional matrix and cut the matrix along the time axis to form subspaces. However, low efficiency of subspaces and difficult fault isolation are the common disadvantages for the principal component model. This paper presents a new subspace construction method based on kernel density estimation function that can effectively reduce the storage amount of the subspace information. The MPCA model and the knowledge base are built based on the new subspace. Then, fault detection and isolation with the squared prediction error (SPE) statistic and the Hotelling (T2) statistic are also realized in process monitoring. When a fault occurs, fault isolation based on the SPE statistic is achieved by residual contribution analysis of different variables. For fault isolation of subspace based on the T2 statistic, the relationship between the statistic indicator and state variables is constructed, and the constraint conditions are presented to check the validity of fault isolation. Then, to improve the robustness of fault isolation to unexpected disturbances, the statistic method is adopted to set the relation between single subspace and multiple subspaces to increase the corrective rate of fault isolation. Finally fault detection and isolation based on the improved MPCA is used to monitor the automatic shift control system (ASCS) to prove the correctness and effectiveness of the algorithm. The research proposes a new subspace construction method to reduce the required storage capacity and to prove the robustness of the principal component model, and sets the relationship between the state variables and fault detection indicators for fault isolation.

  2. 12 CFR 617.7605 - How should System institutions document whether the borrower had the financial resources to avoid...

    Science.gov (United States)

    2010-01-01

    ... How should System institutions document whether the borrower had the financial resources to avoid... 12 Banks and Banking 6 2010-01-01 2010-01-01 false How should System institutions document whether the borrower had the financial resources to avoid foreclosure? 617.7605 Section 617.7605 Banks...

  3. Changes of tolerance of China's English language policy from the aspect of English borrowing into Chinese

    Institute of Scientific and Technical Information of China (English)

    唐弢

    2012-01-01

    In recent years, because of the 'open-door' policy and the increasing role of English as a global language, increasing numbers of English words have been absorbed into Chinese by both direct and indirect borrowing. This article is explored to discuss the way of English borrowing into Chinese and how the changes of China's English language policy have been made.

  4. 7 CFR Appendix A to Subpart C of... - Model Form of Loan Contract for Electric Distribution Borrowers

    Science.gov (United States)

    2010-01-01

    ... or similar power pricing agreement between the Borrower and a power supplier. “Electric System” shall... RUS Commitment. If the RUS Note calls for a prepayment penalty or premium, such amount shall be paid... (premium, if any) or interest on its Notes, if the Borrower is otherwise in default hereunder or if, after...

  5. Land Cover Information for the Upper Colorado River Basin in Maurer et al. (2002) Climate Data resolution (nlcd_UCRB_Maurer_resolution.asc)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — nlcd_UCRB_Maurer_resolution.asc is an Esri ASCII grid representing land cover information for the Upper Colorado River Basin. The 2011 National Land Cover Database...

  6. Hydrologic Soil Group for the Upper Colorado River Basin in Maurer et al. (2002) Climate Data resolution (hsg_UCRB_Maurer_resolution.asc)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — hsg_UCRB_Maurer_resolution.asc is an Esri ASCII grid representing the hydrologic soil group (HSG) for the Upper Colorado River Basin. The HSG for an area is...

  7. Available Water Capacity for the Upper Colorado River Basin in Maurer et al. (2002) Climate Data resolution (awc_UCRB_Maurer_resolution.asc)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — awc_UCRB_Maurer_resolution.asc is an Esri ASCII grid representing the available water capacity (AWC) for the Upper Colorado River Basin. AWC is the amount of water...

  8. Overland Flow Direction Information for the Upper Colorado River Basin in Maurer et al. (2002) Climate Data resolution (overland_flow_direction_UCRB_Maurer_resolution.asc)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — overland_flow_direction_UCRB_Maurer_resolution.asc is an Esri ASCII grid representing overland flow direction in the Upper Colorado River Basin using the D8...

  9. Draft Genome Sequence of Heavy Metal-Resistant Cupriavidus alkaliphilus ASC-732T, Isolated from Agave Rhizosphere in the Northeast of Mexico

    Science.gov (United States)

    Rojas-Rojas, Fernando Uriel; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T. B. K.; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Woyke, Tanja; Shapiro, Nicole

    2016-01-01

    Cupriavidus alkaliphilus ASC-732T was isolated from the rhizosphere of agave plant growing in alkaline soils in San Carlos, Tamaulipas, Mexico. The species is able to grow in the presence of arsenic, zinc, and copper. The genome sequence of strain ASC-732T is 6,125,055 bp with 5,586 genes and an average G+C content of 67.81%. PMID:27660789

  10. Draft Genome Sequence of Heavy Metal-Resistant Cupriavidus alkaliphilus ASC-732T, Isolated from Agave Rhizosphere in the Northeast of Mexico.

    Science.gov (United States)

    Rojas-Rojas, Fernando Uriel; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T B K; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Woyke, Tanja; Shapiro, Nicole; Ibarra, J Antonio; Estrada-de Los Santos, Paulina

    2016-09-22

    Cupriavidus alkaliphilus ASC-732(T) was isolated from the rhizosphere of agave plant growing in alkaline soils in San Carlos, Tamaulipas, Mexico. The species is able to grow in the presence of arsenic, zinc, and copper. The genome sequence of strain ASC-732(T) is 6,125,055 bp with 5,586 genes and an average G+C content of 67.81%.

  11. Developing an Interlibrary Loan Borrowing Policy for Evergreen Valley College Library Patrons. Governance and Management.

    Science.gov (United States)

    Poehlmann, Ruth I.

    The increased use of interlibrary loan (ILL) services at the Evergreen Valley College (EVC) library which resulted from joining OCLC automated Interlibrary Loan subsystem in 1979 led to the development of an Interlibrary Loan Borrowing Policy by the EVC library staff. The policy is designed to explain to library patrons the limitations on…

  12. Advanced Degrees of Debt: Analyzing the Patterns and Determinants of Graduate Student Borrowing

    Science.gov (United States)

    Belasco, Andrew S.; Trivette, Michael J.; Webber, Karen L.

    2014-01-01

    Despite record student debt and the growing importance of graduate education, little is known about what drives graduate student borrowing. In response to that research gap, this study draws on several national data sources to analyze the patterns and predictors of education-related debt among graduate students specifically. Adjusted Wald tests…

  13. 34 CFR 682.202 - Permissible charges by lenders to borrowers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Permissible charges by lenders to borrowers. 682.202 Section 682.202 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General...

  14. Borrowings, Derivational Morphology, and Perceived Productivity in English, 1300-1600

    Science.gov (United States)

    Palmer, Chris C.

    2009-01-01

    This dissertation examines how borrowed derivational morphemes such as "-age," "-ity," "-cion," and "-ment" became productive in the English language, particularly in the fourteenth through sixteenth centuries. It endeavors to expand our current understanding of morphological productivity as a historical phenomenon--to account for not only…

  15. Word Prosody in Loanword Phonology: Focus on Japanese Borrowings into Taiwanese Southern Min

    Science.gov (United States)

    Tu, Jung-yueh

    2013-01-01

    This study investigates the adaptation of word prosody in loanword phonology. First, it explicates several influential loanword theories and reviews some representative cases of prosodic adaptation from different languages. Then, it turns to the focus on the prosodic adaptation of Japanese borrowings into Taiwanese Southern Min (TSM or Taiwanese).…

  16. Is the Tanzanian Ngoni Language Threatened? A Survey of Lexical Borrowing from Swahili

    Science.gov (United States)

    Rosendal, Tove; Mapunda, Gastor

    2014-01-01

    Tanzania's post-independence language policy has promoted Swahili as a means of achieving national and linguistic unity. This policy has affected the Ngoni language in south-western Tanzania. Today, Swahili has permeated communication all over Tanzania, even in rural and remote areas. This paper discusses lexical borrowing and especially…

  17. Negative Borrowing in an Indigenous-Language Shift to the Dominant National Language

    Science.gov (United States)

    Dorian, Nancy C.

    2006-01-01

    Receding languages in contact with an expanding language are susceptible to various forms of transfer, including covert transfer or negative borrowing, the elimination of features not shared by the expanding language. Retention of two Scottish Gaelic grammatical features with English parallels and of two grammatical features without English…

  18. 12 CFR 618.8320 - Data regarding borrowers and loan applicants.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Data regarding borrowers and loan applicants. 618.8320 Section 618.8320 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM GENERAL... association shall hold in strict confidence all information regarding the character, credit standing,...

  19. 7 CFR 1717.158 - Mergers with borrowers who prepaid RUS loans.

    Science.gov (United States)

    2010-01-01

    ... has prepaid RUS debt at a discount pursuant to 7 CFR part 1786, and whose eligibility for future RUS... 7 Agriculture 11 2010-01-01 2010-01-01 false Mergers with borrowers who prepaid RUS loans. 1717.158 Section 1717.158 Agriculture Regulations of the Department of Agriculture (Continued)...

  20. 7 CFR 1710.252 - Construction work plans-power supply borrowers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Construction work plans-power supply borrowers. 1710... LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.252 Construction work plans..., environmental and other studies and plans needed to support the construction of facilities, when such cost...

  1. Floodplain restoration with flood control: fish habitat value of levee borrow pits

    Science.gov (United States)

    Earthen flood control levees are often built using soil excavated from borrow pits lying parallel to and riverward of the finished levee. After construction, these pits can provide valuable floodplain habitats, and their value is well established along corridors of larger rivers. However, levee bo...

  2. Borrowing and Working of Low-Income Students: The Impact of a Summer Transition Program

    Science.gov (United States)

    De La Rosa, Mari Luna

    2012-01-01

    This study focuses on how low-income students determine employment and student loan borrowing options before they begin college, as part of the final stages of their college choice process. More specifically, this study asks, "during a six-week summer transition program, what choices are made by low-income students with employment or borrowing…

  3. 7 CFR 1710.303 - Power cost studies-power supply borrowers.

    Science.gov (United States)

    2010-01-01

    ... this section. (Approved by the Office of Management and Budget under control number 0572-0032) ... AND GUARANTEES Long-Range Financial Forecasts § 1710.303 Power cost studies—power supply borrowers. (a... forecast required by § 1710.302. (b) A power cost study shall include the following basic elements: (1)...

  4. On the rationality of borrowers' behaviour: comparing risk-attitudes of homeowners

    NARCIS (Netherlands)

    Neuteboom, P.

    2008-01-01

    Though time and depth of cycles differed from one European country to another, mortgage markets have grown in size, expanded in product variation and improved borrowers' accessibility to mortgage credit. However, this expanding range of mortgage opportunities significantly increases the search and

  5. 38 CFR 36.4309 - Transfer of title by borrower or maturity by demand or acceleration.

    Science.gov (United States)

    2010-07-01

    ...; (iii) A transfer by devise, descent, or operation of law on the death of a joint tenant or tenant by... option to purchase; (v) A transfer to a relative resulting from the death of a borrower; (vi) A transfer... reinstatement of the loan would adversely affect the dignity of the lien or be otherwise precluded by law. A...

  6. Direct Loans: A Better Way To Borrow. William D. Ford Federal Direct Loan Program.

    Science.gov (United States)

    Department of Education, Washington, DC. Student Financial Assistance.

    The Web site http://www.ed.gov/DirectLoan/ provides information on the William D. Ford Federal Direct Loan Program for both professionals and borrowers. For professionals, it provides information on conferences, promissory notes, regulations, laws, and relevant links, as well as technical assistance, and other publications and guides. For…

  7. Consumption-based learning about brand quality : Essays on how private labels share and borrow reputation

    NARCIS (Netherlands)

    Szymanowski, M.G.

    2009-01-01

    CONSUMPTION-BASED LEARNING ABOUT BRAND QUALITY: ESSAYS ON HOW PRIVATE LABELS SHARE AND BORROW REPUTATION is a collection of essays exploring the process of consumer cross-brand learning in the context of brands belonging to retailers: the so-called private labels. Private labels have gradually grown

  8. Going the Extra Mile: Designing a Delivery Service for Remote Borrowers

    Science.gov (United States)

    Long, Dallas

    2009-01-01

    This article documents the development of delivery services of library materials to remote borrowers at Milner Library, Illinois State University. Responding to a university mandate and guidelines for distance learning authored by the Association of College and Research Libraries, the Access Services librarians at Milner Library investigated the…

  9. Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

    NARCIS (Netherlands)

    Mutti, F.G.; Knaus, T.; Scrutton, N.S.; Breuer, M.; Turner, N.J.

    2015-01-01

    α-Chiral amines are key intermediates for the synthesis of a plethora of chemical compounds at industrial scale. We present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows for the efficient and environmentally benign production of enantiopure amines. The met

  10. PROBLEMS OF DEBT POLICY OF UKRAINE IN THE EXTERNAL BORROWING MARKET AND SOLUTIONS

    Directory of Open Access Journals (Sweden)

    R. Rudyk

    2014-06-01

    Full Text Available Under conditions of formation and functioning of a market economy the role and importance of such component of public finances as public debt enhances. The sustainable economic development of Ukraine is impossible without the use of mechanism of external public borrowings giving rise to the external public debt.

  11. Child Bilingualism in an Immigrant Society: Implications of Borrowing in the Hebrew 'Language of Games.'

    Science.gov (United States)

    Bar-Adon, Aaron

    The first waves of immigrants arriving in Palestine were faced with the problem of forming a new culture and creating a new language, actually, reviving Hebrew, an ancient language. The children were faced with creating their own traditions, games, and folklore; in so doing, through straight borrowing, spontaneous translation (loan translation),…

  12. Lexical Borrowing in the Speech of First-Generation Hungarian Immigrants in Australia

    Directory of Open Access Journals (Sweden)

    Anikó Hatoss

    2016-09-01

    Full Text Available This article reports findings of a sociolinguistic project which investigated language contact phenomena in the speech of first-generation Hungarian Australians living in Sydney. The research aimed to identify and analyze English lexical items borrowed into the spoken Hungarian of first-generation Hungarian–English bilinguals. This research had a mixed methods approach including a quantitative element (count of lexical manifestations by categories such as part of speech and a qualitative element in which the various lexical manifestations have been subjected to a linguistic analysis. The Hungarian National Corpus was used as a reference guide to determine the status of these phenomena in the lexicon of Standard Hungarian. The data were collected through semi-structured sociolinguistic interviews with 22 Hungarian Australians living in Sydney. The findings demonstrate that (a first-generation Hungarians are highly creative language users and integrate a large number of English lexical items into their speech. Most lexical borrowings belong to the derivational blends with the highest proportion of the nominal group. Lexical borrowings from English are morphologically integrated with Hungarian-derivational suffixes and inflectional case markings. This research provides original empirical data to better understand the various inter-language lexical manifestations in Hungarian–English bilingual contexts. The study adds to the relatively small body of research on Hungarian–English bilingualism in diasporic context and contributes to understanding lexical borrowing from a contact linguistic perspective.

  13. 75 FR 17303 - Section 108 Community Development Loan Guarantee Program: Participation of States as Borrowers...

    Science.gov (United States)

    2010-04-06

    ... URBAN DEVELOPMENT 24 CFR Part 570 RIN 2506-AC28 Section 108 Community Development Loan Guarantee Program: Participation of States as Borrowers Pursuant to Section 222 of the Omnibus Appropriations Act, 2009 AGENCY: Office of the Assistant Secretary for Community Planning and Development, HUD. ACTION: Final...

  14. 25 CFR 103.26 - What must the borrower supply the lender in its loan application?

    Science.gov (United States)

    2010-04-01

    ... cash flow statements; (i) A detailed list of all proposed collateral for the loan, including asset... eligibility under the Program; (c) A statement signed by the borrower, indicating that it is not delinquent on... balance sheets and operating statements for the preceding 3 years, or so much of that period that the...

  15. An empirical analysis of borrowing behaviour of higher education students in the Netherlands

    NARCIS (Netherlands)

    Oosterbeek, H.; van den Broek, A.

    2009-01-01

    Many higher education students combine their study with a job on the side instead of taking up a loan. This paper examines the factors underlying this apparently myopic behaviour. We find that standard economic factors explain observed borrowing decisions to some extent. Students with easier access

  16. 7 CFR 1724.10 - Standard forms of contracts for borrowers.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND..., engineering services, and architectural services financed by a loan made or guaranteed by RUS. This part... how borrowers are required to use RUS standard forms of contracts for engineering and architectural...

  17. Complexities and Dynamics of Korean Graduate Students' Textual Borrowing in Academic Writing

    Science.gov (United States)

    Rhee, Eunsook Ha

    2010-01-01

    Academic writing in U.S. higher education often involves textual borrowing, referred to as the integration and documentation of reading sources and carried out with summaries, quotes, and paraphrases. Second language (L2) English students are likely to use sources inappropriately and consequentially are accused of plagiarism based on university…

  18. The Ghosts of Higher Education Reform: On the Organisational Processes Surrounding Policy Borrowing

    Science.gov (United States)

    Brøgger, Katja

    2014-01-01

    The Bologna Process is one of the most extensive examples of policy borrowing processes. Based on qualitative data, this article argues in favour of studying part of this process as "global smallness", centring on the organisational effects of the implementation of a globalised curriculum. Through Derrida's notion on hauntology,…

  19. 34 CFR 682.301 - Eligibility of borrowers for interest benefits on Stafford and Consolidation loans.

    Science.gov (United States)

    2010-07-01

    ... the student, must submit a statement to the lender pursuant to § 682.603. The student must qualify for... benefits on a Stafford loan, a borrower must demonstrate financial need in accordance with Part F of the... financial need if that organization— (i) Has as its primary objective the promotion of ideals and...

  20. 7 CFR Appendix A to Subpart B of... - Model Form of Mortgage for Electric Distribution Borrowers

    Science.gov (United States)

    2010-01-01

    ... 3.09Preservation of Corporate Existence and Franchises SECTION 3.10Limitations on Consolidations and... it necessary to borrow money for its corporate purposes and to issue its promissory notes and other... Finance Corporation, the National Bank for Cooperatives and the St. Paul Bank for Cooperatives other than...

  1. EXTERNAL BORROWING – A SOLUTION IN OVERCOMING THE CURRENT ECONOMIC CRISIS?

    Directory of Open Access Journals (Sweden)

    Maria Pascal (căs. Andriescu

    2010-06-01

    Full Text Available The government decisions to call, in recent years, more and more reimbursable financing gave birth to fierce reactions among politicians and economy specialists. The present article aims to analyze how the external borrowing may be a solution to overcome the difficult situation where we are.

  2. Mixed Messages: The Problem of Class in Mary Norton's "Borrowers" Series

    Science.gov (United States)

    Travis, Madelyn

    2007-01-01

    Scholars have posited various theories as to which sector of society Mary Norton's Borrowers most closely reflect, from exploitative aristocrats to helpless victims. Through social and literary contextualization, this article highlights the ways in which Norton represents social class in the series and explores the competing ideologies embedded in…

  3. Borrowing of the International Monetary Fund during the global financial and economic crisis

    Directory of Open Access Journals (Sweden)

    Gnjatović Dragana

    2015-01-01

    Full Text Available The paper analyses the rapid growth of borrowing of the International Monetary Fund during the global financial and economic crisis. According to the Articles of Agreement of the IMF, the basis of its financial resources consists of its own funds created from paid-in capital (quotas by the Member States. Only if it appears to be that those resources are not sufficient for its ongoing financial operations, the Fund has a possibility to borrow. However, due to the large growth of demand for the Fund's resources induced by the global financial and economic crisis since 2008, the dominant position in the structure of its financial resources has been overtaken by borrowing on bilateral and multilateral grounds. The aim of this paper is to examine the reasons why borrowing has by far overgrown the role of supplementary source of the IMF resources during the crisis. The paper starts from the hypothesis that the reasons are of institutional nature since the very method of decision making on overall quota increase did not leave any room for a rapid reaction. Namely, the IMF could only respond quickly and effectively to the sharply increased demand of the Member States hit by the crisis by relying on borrowing. The one hundred percent increase in credit potential of the Fund, its scale unprecedented in the seventy-year long history of the IMF operations, would not have been possible had it waited for the realization of the decision on general quotas increase within their, fourteenth in the row, review.

  4. 25 CFR 103.27 - Can the borrower get help preparing its loan application or putting its loan funds to use?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can the borrower get help preparing its loan application or putting its loan funds to use? 103.27 Section 103.27 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT... Relating to Borrowers § 103.27 Can the borrower get help preparing its loan application or putting its...

  5. Clinical significance of detection of HPV feedback on patients with cervical cytology ASC-H%对宫颈细胞学ASC-H患者进行反馈性HPV检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    林文毅; 陈颖; 王世凤; 胡志敏; 赖娜; 王敏

    2015-01-01

    Objective: To discuss the clinical significance of HPV (human papilloma virus)-detection in women with cervical ASC-H (atypical squamous cell cannotexclude high-grade squamous intraepithelial lesion). Methods: Retrospective analysis of the HPV-feedback test and histopathological findings in 197 cases of patients with ASC-H from June 2012 to June 2014. Results: Collected 197 cases of ASC-H patients diagnosed through cervical cytology in our hospital from June 2012 to June 2014. 124 cases gave the feedback tests of HPV and cervical tissue examination results, who were female, aged 25-63 years, with an average age of about 46 years old;clinical manifestations include cervical erosion,the real bleeding,physical examinations and others. 92 cases with the HPV positive, including histopathological findings as inflammation and 22 normal cases,accounting for about 23.91%, 15 cases with the low level of cervical intraepithelial neoplasia (CINI) ,accounting for about 16.3% , 45 cases with advanced differentiation of cervical intraepithelial neoplasia (cervical intraepithelial neopsia. CINII/CINIII), 10 cases with carcinoma, accounted for 59.78%, 32 cases of HPV negative, including histopathological findings as inflammation and 23 cases of normal, accounting for about 71.88%,8 cases with the low level of cervical intraepithelial neoplasia (CINI),accounting for about 25%,1 case with advanced differentiation of cervical intraepithelial neoplasia (CINII), accounting for about 3.12%, CINIII and squamous cell carcinoma were detected negatively. Thus the HPV detection has higher predictive value for lesions in high grade cervical intraepithelial cancer , risk of high-grade cervical intraepithelial lesion in HPV positive ASC-H patients were higher than the negative group (P< 0.05). Conclusion HPV feedback inspection in all ASC-H patients is very useful. Treatments could be provided more reasonable and personalized, while excessive examinations and treatments could be avoided and the

  6. Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H cannot be ruled out

    Directory of Open Access Journals (Sweden)

    Andréa Cytryn

    Full Text Available CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS into ASC-US (undetermined significance and ASC-H (high-grade intraepithelial lesion cannot be ruled out. The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55% and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764. Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83; P = 0.2786998. There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.

  7. Some Opinion on the Term of ASC-US in Cervical Cytological Test%关于子宫颈细胞学检查ASC-US术语的几点认识

    Institute of Scientific and Technical Information of China (English)

    李晴; 黄美娥; 古晓红; 麦凤珍; 刘植华

    2007-01-01

    子宫颈脱落细胞学检查被认为是医学史上最成功的早期癌症筛查方法之一。1988年美国阴道镜和细胞病理协会(ASCCP)修改了宫颈/阴道细胞病理学诊断方式,废除“巴氏五级分类法”,推出描述性诊断报告方式(Thebe—thesda system,TBS),由此,报告中出现了一种“不能明确诊断意义的不典型鳞状上皮细胞(ASC-US)”的术语。目前对ASC—US的临床意义有多种释义,在临床工作中可能出现一些认识误区。现对我院2005年子宫颈脱落细胞学检查筛查出的ASC-US病例资料进行分析,

  8. Clay hydration and crystal growth in expansive anhydritic claystone. The Ascó Power Plant case

    Science.gov (United States)

    Alonso, Eduardo; Ramon, Anna

    2015-04-01

    A large power plant directly founded on a hard claystone experienced, soon after the construction of the foundation slabs, a continuous heave developing at decreasing rate, which has been active for the last 35 years. When undisturbed (i.e., at some depth, in the range of several meters) Ascó claystone exhibits high unconfined compressive strengths (30-40 MPa). In high quality cores the rock has a massive aspect and discontinuities are difficult to observe. The rock has a Tertiary origin and horizontal layers at spacing of 1-4 m could be identified. Whitish seams of gypsum, bassanite or anhydrite are also observed within the reddish rock matrix. Minerals identified in deep cores are quartz (10%), calcite and dolomite (50-70%), clay minerals (10-20%) and gypsum and anhydrite (2-20%). Among the clay minerals, illite dominates (10%). Smectite or smectite-interbedded minerals do not amount in general to more than 5%. The undisturbed rock has a low porosity (6-11%) and low water content (2-5%). Because of the presence of hydrated sulphates, water content and degree of saturation (Sr=0.8-0.9 was found) are somewhat uncertain. However, high suctions were found in recovered cores. This rock changes into a weathered material at shallow depths. Mineralogy is not much affected but porosity increases to 22-29% and water content increases to 10-19%. Strength drops to small values (soil like) and a lower "in situ" suction has been measured (0.4-7.1 MPa). The added pore volume of the weathered material, if compared with the deep rock, is filled with water. The heave of the station was attributed to the hydration of undisturbed rock under the building slabs of the power plant. In fact, large excavations preceded the layout of foundations. As a result, atmospheric water had an easy access to the intact rock. The installation of a compacted soil fill around the buildings allowed the presence of a permanent water table which could infiltrate into the rock. Piezometric data provided

  9. Low-frequency, low-magnitude vibrations (LFLM enhances chondrogenic differentiation potential of human adipose derived mesenchymal stromal stem cells (hASCs

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-02-01

    Full Text Available The aim of this study was to evaluate if low-frequency, low-magnitude vibrations (LFLM could enhance chondrogenic differentiation potential of human adipose derived mesenchymal stem cells (hASCs with simultaneous inhibition of their adipogenic properties for biomedical purposes. We developed a prototype device that induces low-magnitude (0.3 g low-frequency vibrations with the following frequencies: 25, 35 and 45 Hz. Afterwards, we used human adipose derived mesenchymal stem cell (hASCS, to investigate their cellular response to the mechanical signals. We have also evaluated hASCs morphological and proliferative activity changes in response to each frequency. Induction of chondrogenesis in hASCs, under the influence of a 35 Hz signal leads to most effective and stable cartilaginous tissue formation through highest secretion of Bone Morphogenetic Protein 2 (BMP-2, and Collagen type II, with low concentration of Collagen type I. These results correlated well with appropriate gene expression level. Simultaneously, we observed significant up-regulation of α3, α4, β1 and β3 integrins in chondroblast progenitor cells treated with 35 Hz vibrations, as well as Sox-9. Interestingly, we noticed that application of 35 Hz frequencies significantly inhibited adipogenesis of hASCs. The obtained results suggest that application of LFLM vibrations together with stem cell therapy might be a promising tool in cartilage regeneration.

  10. Agent or Borrower? An Incentive of Moral Hazard with China Commercial Guarantee Company

    Directory of Open Access Journals (Sweden)

    Feng He

    2014-01-01

    Full Text Available This paper studies the behavior of commercial guarantee company in the game theory framework. Different payoff structures with guarantee company behavior for banks, borrowers, and the guarantors are formed in the presence of credit rationing. We derived and explained the surviving rule of different types of guarantee companies, and we further conclude the condition in which guarantee companies are likely to be involved in a moral hazard problem. We conclude that, in the presence of regulatory arbitrage opportunity, the guarantee company has incentive to switch its role from bank agent to the borrower, being a second-hand lender. When the macroeconomic risk is high, the switching of this role will transfer the risk back to the banks.

  11. The Political Economy of Sovereign Borrowing: Explaining the Policy Choices of Highly Indebted Governments

    OpenAIRE

    Stephen B. Kaplan; Kaj Thomsson

    2014-01-01

    In newly democratized and developing countries, political economy theory expects politicians to use budget defcits to engineer an election-timed boom, known as the political business cycle. In this paper, we challenge this view by incorporating the Önancial constraints faced by government into an electoral political framework. Debtor governments must often borrow from foreign creditors to fund their domestic spending. Employing a formal model, we show theoretically that the extent of ownershi...

  12. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  13. An Analysis on Borrowing Behavior of Rural Households in Vientiane Municipality: Case Study of Four Villages

    Directory of Open Access Journals (Sweden)

    Chansathith Chaleunsinh

    2015-03-01

    Full Text Available Since the late 1990s the savings groups have been introduced in the villages of Laos. This movement has offered new borrowing opportunities for the rural people. Based on household survey using a structured questionnaire in four study villages (N=684 in Vientiane Municipality during 2007–08 we analyzed the role and performance of the savings group in rural financial markets, especially focusing on who borrows, from which sources, and for what purposes by comparing the savings group with informal and formal lenders. Two major findings are as follows. First, three types of lenders (savings groups, formal and informal lenders have their own particular features, and thereby loan purposes differ significantly. Formal banks offer loans exclusively for production purposes, while informal lenders do for coping with emergencies. Savings groups fall between them. Second, though poor households are reluctant to be a savings group member, once they participate in they actively obtain loans from it. In contrast, though rich households actively participate in the group, they obtain loans less from it. Group members claim that the primary purpose of joining the savings group is to cope with emergencies. When the members obtain loans from the savings group, however, nearly 40% of the loans are used for production purposes, mainly in agriculture. There exists a change between saving purposes and borrowing ones. It is assumed that in villages with the higher loan credit for production purposes, the savings groups show favorable performance, and thus a rapid growth.

  14. 美国输电线路风荷载计算介绍%Introduction of Wind Load Computation of Transmission Line in ASCE74-2009

    Institute of Scientific and Technical Information of China (English)

    王振华

    2012-01-01

    了解《美国输电线路结构荷载指南》( ASCE74-2009)对从事涉外工程和提高工程师设计水平都有着重要意义.风荷载是输电线路设计的控制荷载,了解ASCE74-2009风荷载计算方法非常有必要.本文介绍了ASCE74-2009输电线路风荷载的计算方法,并对基本风速、风压高度变化系数、体型系数、风荷载调整系数、地形影响因子和斜向风荷载计算方法及其计算参数进行了说明.%It is very important to comprehend 《 Guidelines for electrical transmission line structural loading》 (ASCE74-2009) for overseas projects and improve the design level of engineer. Wind load is the control load for transmission line, so it is necessary to master wind load computation method of ASCE74-2009. Wind load computation formulas for transmission line of ASCE74-2009 are introduced in this paper. The computation parameters of basic wind speed, height variation factor of wind pressure, shape factor, wind load factor, topographic factor and yawed wind load computation method are illustrated in detail.

  15. Differential expression of specific FGF ligands and receptor isoforms during osteogenic differentiation of mouse Adipose-derived Stem Cells (mASCs) recapitulates the in vivo osteogenic pattern.

    Science.gov (United States)

    Quarto, Natalina; Longaker, Michael T

    2008-11-15

    The ability of Adipose-derived Stem Cells (ASCs) to differentiate into various tissues in vitro and in vivo, a function known as "stem cell plasticity", makes them an appealing cell source for tissue engineering. Our laboratory is particularly focused on the potential role of adipose tissue as a readily available postnatal source of osteoprogenitor. Fibroblast growth factors (FGF) and their receptors (FGFR) are important regulators of osteogenesis. The goal of this study was to elucidate how changes in temporal expression patterns of individual components of the fibroblast growth factor (FGF) signaling axis correlate with osteogenic differentiation of mASCs. Our results indicate that FGF ligand genes, such as Fgf-2, -4, -8, and -18, displayed a differential and dynamic profile during mouse ASC (mASC) osteogenesis. Fgf-2 transcript was down-regulated, while Fgf-18 transcript level was strongly up-regulated. Interestingly, a drift in the ratio of different FGF-2 protein forms, with translation favoring the HMWFGF-2 forms, occurred during osteogenic differentiation, whereas, the expression of LMWFGF-2 form was down-regulated. This finding shares similarity with a previous study suggesting that preferential expression of the HMWFGF-2 forms is associated with a more osteogenic differentiated state of calvarial osteoblast. Moreover, a differential expression of Fgf Receptor 1 and 2 resembling that previously found in in vivo osteogenic study was observed. Thus, mASCs undergoing osteogenesis recapitulate the in vivo osteogenic differentiation expression pattern of FGF ligands and receptors of calvarial mesenchymal cells during their own osteogenic differentiation. Indeed, this observation further validates ASCs as a suitable resource for skeletal tissue engineering.

  16. A Comparative Study on the Book Recognition Modes of Auto-self Borrow and Return System%自助借还书系统图书识别模式分析

    Institute of Scientific and Technical Information of China (English)

    龚胜泉

    2012-01-01

    自助借还书系统的使用能有效延长图书馆的借还书时间、降低图书馆工作人员的劳动强度。传统的条形码与RFID两种图书识别模式自助借还书系统在实际使用中存在着一些问题。本文针对这些问题,在介绍ColorBit标签的基本识别原理的基础上,提出将ColorBit图书识别标签技术应用于自助借还书系统以克服传统图书识别模式自助借还系统的不足,并提出了该模式下自助借还系统的基本流程方案。%Auto-self borrow and return system could extend borrow and return service hours of library,and reduce the labor intensity of librarians,but auto-self borrow and return system based on traditional barcode and RFID recognition modes have some disadvantages.To solve the problems,on the basis of introducing the recognition fundament of CorlorBit label,this paper raises the method of applying CorlorBit label technology into auto-self borrow and return system.At the end of this paper,the basic work flow of system is presented.

  17. Gaia16asc, Gaia16ase, Gaia16asj and Gaia16ask candidate supernovae near galaxies confirmed by Mercator/Maia imaging

    Science.gov (United States)

    Blanco-Cuaresma, S.; Semaan, T.; Roelens, M.; Palaversa, L.; Mowlavi, N.; Eyer, L.

    2016-07-01

    We report confirmation of Gaia Science Alerts transients Gaia16asc, Gaia16ase, Gaia16asj and Gaia16ask. Images were obtained in G and R bands of the Maia instrument mounted to the Flemish 1.2m Mercator telescope at Roque de los Muchachos observatory, La Palma, Canary Islands, Spain, on 2016 July 02 - 04. These new sources are supernovae candidates near galaxies and they are not visible in archival 2MASS and DSS images: Gaia16asc, Gaia16ase, Gaia16asj and Gaia16ask.

  18. Iceland's Language Technology: Policy versus Practice

    Science.gov (United States)

    Hilmarsson-Dunn, Amanda M.; Kristinsson, Ari P.

    2009-01-01

    Iceland's language policies are purist and protectionist, aiming to maintain the grammatical system and basic vocabulary of Icelandic as it has been for a thousand years and to keep the language free of foreign (English) borrowings. In order to use Icelandic in the domain of information technology, there has been a major investment in language…

  19. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2016-01-01

    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  20. Overexpression of the tomato asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B-1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp lycopersici in Nicotiana umbratica plants

    NARCIS (Netherlands)

    Brandwagt, BF; Kneppers, TJA; Nijkamp, HJJ; Hille, J

    2002-01-01

    The sphinganine-analog mycotoxins (SAMs) fumonisin B-1 and AAL toxins are inhibitors of eukaryotic sphinganine N-acyltransferase in vitro. Treatment of eukaryotes with SAMs generally results in an accumulation of sphingoid base precursors and a depletion of complex sphingolipids. The asc,asc genotyp

  1. Overexpression of the Tomato Asc-1 Gene Mediates High Insensitivity to AAL Toxins and Fumonisin B1 in Tomato Hairy Roots and Confers Resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica Plants

    NARCIS (Netherlands)

    Brandwagt, Bas F.; Kneppers, Tarcies J.A.; Nijkamp, H. John J.; Hille, Jacques

    2002-01-01

    The sphinganine-analog mycotoxins (SAMs) fumonisin B1 and AAL toxins are inhibitors of eukaryotic sphinganine N-acyltransferase in vitro. Treatment of eukaryotes with SAMs generally results in an accumulation of sphingoid base precursors and a depletion of complex sphingolipids. The asc,asc genotype

  2. Borrow or Serve? An Economic Analysis of Options for Financing a Medical School Education.

    Science.gov (United States)

    Marcu, Mircea I; Kellermann, Arthur L; Hunter, Christine; Curtis, Jerri; Rice, Charles; Wilensky, Gail R

    2017-07-01

    To understand the long-term economic implications of key pathways for financing a medical school education. The authors calculated the net present value (NPV) of cash flow over a 30-year career for a 2013 matriculant associated with (1) self-financing, (2) federally guaranteed loans, (3) the Public Service Loan Forgiveness program, (4) the National Health Service Corps, (5) the Armed Forces Health Professions Scholarship Program, and (6) matriculation at the Uniformed Services University of the Health Sciences. They calculated the NPV for students pursuing one of four specialties in two cities with divergent tax policies. Borrowers were assumed to have a median level of debt ($180,000), and conservative projections of inflation, discount rates, and income growth were employed. Sensitivity analyses examined different discount and income growth rates, alternative repayment strategies, and various lengths of public-sector service by scholarship recipients. For those wealthy enough to pay cash or fortunate enough to secure a no-strings scholarship, self-financing produced the highest NPV in almost every scenario. Borrowers start practice $300,000 to $400,000 behind their peers who secure a national service scholarship, but those who enter a highly paid specialty, such as orthopedic surgery, overtake their national service counterparts 4 to 11 years after residency. Those in lower-paid specialties take much longer. Borrowers who enter primary care never close the gap. Over time, the value of a medical degree offsets the high up-front cost. Debt avoidance confers substantial economic benefits, particularly for students interested in primary care.

  3. Alumina-entrapped Ag catalyzed nitro compounds coupled with alcohols using borrowing hydrogen methodology.

    Science.gov (United States)

    Liu, Huihui; Chuah, Gaik Khuan; Jaenicke, Stephan

    2015-06-14

    Supported silver catalysts were reported for the first time to be able to catalyze the coupling reaction between nitroarenes and alcohols via the borrowing hydrogen scheme. The recyclable, non-leaching catalyst is synthesized by the entrapment method, which allows entrapping of silver nanoparticles in an alumina matrix. Alcohols, acting as the reducing agents for nitro-groups, alkylated the resultant amines smoothly over these silver catalysts giving a yield of >98% towards the N-substituted amines. In this process, multiple steps were realized in one-pot over a single catalyst with very high efficiency. It offers another clean and economic way to achieve amination of alcohols.

  4. Convex Duality in Portfolio Optimization under Constraints and with Higher Interest Rate for Borrowing

    Institute of Scientific and Technical Information of China (English)

    雷耀斌; 吴让泉

    2001-01-01

    We study the stochastic control problem of maximizing expected utility from terminal wealth and/or consumption, when the portfolio is constrained to take values in a given closed, convex subset of Ra, and in the presence of a higher interest rate for borrowing. The setting is that of a continuous-time, Ito process model for the underlying asset prices. The solution of the unconstrained problem is given. In addition to the original constrained optimization problem, a so-called combined dual problem is introduced. Finally, the existence question of optimal processes for both the dual and the primal problem is settled.

  5. Borrowing to cope with adverse health events: liquidity constraints, insurance coverage, and unsecured debt.

    Science.gov (United States)

    Babiarz, Patryk; Widdows, Richard; Yilmazer, Tansel

    2013-10-01

    This article uses data from the Health and Retirement Study for 1998-2010 to investigate whether households respond to the financial stress caused by health problems by increasing their unsecured debt. Results show both the probability of having unsecured debt and the amount of debt increase after an adverse health event among households with low financial assets, who are uninsured, or who have less generous health insurance. The effect of health problems on borrowing is caused by both medical expenditures and disruptions to the income stream. Unsecured debt seems to remain on some households' balance sheets for an extended period.

  6. ANALYSIS OF INFLUENCE OF FINANCIAL SOCIAL LEARNING OPPORTUNITIES ON LOAN REPAYMENT BEHAVIOUR OF COOPERATOR BORROWERS IN ABIA STATE, NIGERIA

    Directory of Open Access Journals (Sweden)

    Christopher Ogbonna EMEROLE

    2014-12-01

    Full Text Available This study on analysis of influence of financial social learning opportunities on loan repayment behavior of cooperator borrowers was carried out in Abia State, Nigeria. It was the objectives of the study to relate social learning financial opportunities in cooperative societies and member borrowers budgeting and timely repayment of loans; and determine demographic, social learning and financial factors that influenced loan repayment by cooperator borrowers. Two-stage random sampling technique was used in selecting first, two of the three agricultural zones; and second two registered farmers’ multi-purpose agricultural cooperative societies. This was followed by purposive selection from registers of the chosen cooperative societies sixty cooperators who currently were repaying loans borrowed. Descriptive and inferential statistical techniques were used in analyzing the gathered cross sectional data. Results suggest important relationships between financial social learning opportunities in cooperative societies and borrowers’ budgeting and timely loan repayment behaviours. Attendance to meetings, discussions with fellow cooperators and meaningful observation on financial behaviour of members of cooperative societies had significant positive influences on conduct and performance loan beneficiaries. The number of times beneficiaries attended meeting since after loan(s were received; number of times they discussed loan matters with members before loan(s were received; and number of times they discussed loan repayment strategies with other cooperators after loans were received had positive influences on loan repayment behaviour of cooperator borrowers. Cooperator(s should participate in all union activities to truly belong and reap the benefits of being a member

  7. The effect of magnetic stimulation on the osteogenic and chondrogenic differentiation of human stem cells derived from the adipose tissue (hASCs)

    Energy Technology Data Exchange (ETDEWEB)

    Lima, João; Gonçalves, Ana I.; Rodrigues, Márcia T.; Reis, Rui L. [3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães (Portugal); ICVS/3Bs–PT Government Associate Laboratory, Braga/Guimarães (Portugal); Gomes, Manuela E., E-mail: megomes@dep.uminho.pt [3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães (Portugal); ICVS/3Bs–PT Government Associate Laboratory, Braga/Guimarães (Portugal)

    2015-11-01

    The use of magnetic nanoparticles (MNPs) towards the musculoskeletal tissues has been the focus of many studies, regarding MNPs ability to promote and direct cellular stimulation and orient tissue responses. This is thought to be mainly achieved by mechano-responsive pathways, which can induce changes in cell behavior, including the processes of proliferation and differentiation, in response to external mechanical stimuli. Thus, the application of MNP-based strategies in tissue engineering may hold potential to propose novel solutions for cell therapy on bone and cartilage strategies to accomplish tissue regeneration. The present work aims at studying the influence of MNPs on the osteogenic and chondrogenic differentiation of human adipose derived stem cells (hASCs). MNPs were incorporated in hASCs and cultured in medium supplemented for osteogenic and chondrogenic differentiation. Cultures were maintained up to 28 days with/without an external magnetic stimulus provided by a magnetic bioreactor, to determine if the MNPs alone could affect the osteogenic or chondrogenic phenotype of the hASCs. Results indicate that the incorporation of MNPs does not negatively affect the viability nor the proliferation of hASCs. Furthermore, Alizarin Red staining evidences an enhancement in extracellular (ECM) mineralization under the influence of an external magnetic field. Although not as evident as for osteogenic differentiation, Toluidine blue and Safranin-O stainings also suggest the presence of a cartilage-like ECM with glycosaminoglycans and proteoglycans under the magnetic stimulus provided. Thus, MNPs incorporated in hASCs under the influence of an external magnetic field have the potential to induce differentiation towards the osteogenic and chondrogenic lineages. - Highlights: • Cellular viability was not negatively influenced by the nanoparticles. • Chondrogenic medium influences more the synthesis of cartilage-like ECM than MNPs. • Synergetic effect among

  8. The effect of magnetic stimulation on the osteogenic and chondrogenic differentiation of human stem cells derived from the adipose tissue (hASCs)

    Science.gov (United States)

    Lima, João; Gonçalves, Ana I.; Rodrigues, Márcia T.; Reis, Rui L.; Gomes, Manuela E.

    2015-11-01

    The use of magnetic nanoparticles (MNPs) towards the musculoskeletal tissues has been the focus of many studies, regarding MNPs ability to promote and direct cellular stimulation and orient tissue responses. This is thought to be mainly achieved by mechano-responsive pathways, which can induce changes in cell behavior, including the processes of proliferation and differentiation, in response to external mechanical stimuli. Thus, the application of MNP-based strategies in tissue engineering may hold potential to propose novel solutions for cell therapy on bone and cartilage strategies to accomplish tissue regeneration. The present work aims at studying the influence of MNPs on the osteogenic and chondrogenic differentiation of human adipose derived stem cells (hASCs). MNPs were incorporated in hASCs and cultured in medium supplemented for osteogenic and chondrogenic differentiation. Cultures were maintained up to 28 days with/without an external magnetic stimulus provided by a magnetic bioreactor, to determine if the MNPs alone could affect the osteogenic or chondrogenic phenotype of the hASCs. Results indicate that the incorporation of MNPs does not negatively affect the viability nor the proliferation of hASCs. Furthermore, Alizarin Red staining evidences an enhancement in extracellular (ECM) mineralization under the influence of an external magnetic field. Although not as evident as for osteogenic differentiation, Toluidine blue and Safranin-O stainings also suggest the presence of a cartilage-like ECM with glycosaminoglycans and proteoglycans under the magnetic stimulus provided. Thus, MNPs incorporated in hASCs under the influence of an external magnetic field have the potential to induce differentiation towards the osteogenic and chondrogenic lineages.

  9. Environmental impact of non-certified versus certified (ASC) intensive Pangasius aquaculture in Vietnam, a comparison based on a statistically supported LCA.

    Science.gov (United States)

    Nhu, Trang T; Schaubroeck, Thomas; Henriksson, Patrik J G; Bosma, Roel; Sorgeloos, Patrick; Dewulf, Jo

    2016-12-01

    Pangasius production in Vietnam is widely known as a success story in aquaculture, the fastest growing global food system because of its tremendous expansion by volume, value and the number of international markets to which Pangasius has been exported in recent years. While certification schemes are becoming significant features of international fish trade and marketing, an increasing number of Pangasius producers have followed at least one of the certification schemes recognised by international markets to incorporate environmental and social sustainability practices in aquaculture, typically the Pangasius Aquaculture Dialogue (PAD) scheme certified by the Aquaculture Stewardship Council (ASC). An assessment of the environmental benefit of applying certification schemes on Pangasius production, however, is still needed. This article compared the environmental impact of ASC-certified versus non-ASC certified intensive Pangasius aquaculture, using a statistically supported LCA. We focused on both resource-related (water, land and total resources) and emissions-related (global warming, acidification, freshwater and marine eutrophication) categories. The ASC certification scheme was shown to be a good approach for determining adequate environmental sustainability, especially concerning emissions-related categories, in Pangasius production. However, the non-ASC certified farms, due to the large spread, the impact (e.g., water resources and freshwater eutrophication) was possibly lower for a certain farm. However, this result was not generally prominent. Further improvements in intensive Pangasius production to inspire certification schemes are proposed, e.g., making the implementation of certification schemes more affordable, well-oriented and facilitated; reducing consumed feed amounts and of the incorporated share in fishmeal, especially domestic fishmeal, etc. However, their implementation should be vetted with key stakeholders to assess their feasibility. Copyright

  10. Assessment of 25 kW free-piston Stirling technology alternatives for solar applications

    Science.gov (United States)

    Erbeznik, Raymond M.; White, Maurice A.; Penswick, L. B.; Neely, Ronald E.; Ritter, Darren C.; Wallace, David A.

    The final design, construction, and testing of a 25-kW free-piston advanced Stirling conversion system (ASCS) are examined. The final design of the free-piston hydraulic ASCS consists of five subsystems: heat transport subsystem (solar receiver and pool boiler), free-piston hydraulic Stirling engine, hydraulic subsystem, cooling subsystem, and electrical and control subsystem. Advantages and disadvantages are identified for each technology alternative. Technology alternatives considered are gas bearings vs flexure bearings, stationary magnet linear alternator vs moving magnetic linear alternator, and seven different control options. Component designs are generated using available in-house procedures to meet the requirements of the free-piston Stirling convertor configurations.

  11. CAN THE MUSLIM WORLD BORROW FROM INDONESIAN CONSTITUTIONAL REFORM? A Comparative Constitutional Approach

    Directory of Open Access Journals (Sweden)

    Nadirsyah Hosen

    2007-06-01

    Full Text Available This paper attempts to analytically examine the possibility of constitutional borrowing for the Muslim world regardless the differences in history, system, culture, language, and cha­racteristics. It discusses this issue by looking at the arguments put forth by the oppo­nents of comparative cons­titutional interpre­tation and their counter arguments. It will consider materials from Canada, USA, South Africa, Singapore, Malaysia, and Hungary, taking the position that constitutional borrowing can be justified. The paper argues that the 1999-2002 Indonesian constitutional reform should be taken into account by other Muslim countries in undertaking their constitutional reform. The substantive approach of the Shari‘ah that has been used in Indonesia has shown that Muslim world can reform its constitutions without the “assistance” of Western foreign policy. Indo­nesian constitutional reform has demonstrated that Islamic constitutionalism comes from within Islamic teaching and the Islamic community itself; it is a home grown product.

  12. Covariate-adjusted borrowing of historical control data in randomized clinical trials.

    Science.gov (United States)

    Han, Baoguang; Zhan, Jia; John Zhong, Z; Liu, Dawei; Lindborg, Stacy

    2017-07-01

    The borrowing of historical control data can be an efficient way to improve the treatment effect estimate of the current control group in a randomized clinical trial. When the historical and current control data are consistent, the borrowing of historical data can increase power and reduce Type I error rate. However, when these 2 sources of data are inconsistent, it may result in a combination of biased estimates, reduced power, and inflation of Type I error rate. In some situations, inconsistency between historical and current control data may be caused by a systematic variation in the measured baseline prognostic factors, which can be appropriately addressed through statistical modeling. In this paper, we propose a Bayesian hierarchical model that can incorporate patient-level baseline covariates to enhance the appropriateness of the exchangeability assumption between current and historical control data. The performance of the proposed method is shown through simulation studies, and its application to a clinical trial design for amyotrophic lateral sclerosis is described. The proposed method is developed for scenarios involving multiple imbalanced prognostic factors and thus has meaningful implications for clinical trials evaluating new treatments for heterogeneous diseases such as amyotrophic lateral sclerosis. Copyright © 2017 John Wiley & Sons, Ltd.

  13. CLASSIFICATION OF GROUND BEETLES (COLEOPTERA, CARABIDAE IN SPECIES AND GENERA USING ASC-ANALYSIS OF THEIR IMAGES

    Directory of Open Access Journals (Sweden)

    Lutsenko Y. V.

    2016-09-01

    considered the further possibility of using the method of ASC- analysis to classify insects, not only in species but also in genera, orders, thereby increasing the reliability of determination of ground beetles, which will be done in this article. A numerical example is given. We also have gained a successful experience of solving such problems in other subject areas. This article can be considered as a continuation of the series of works dedicated to governmental use of the automated system-cognitive analysis (ASC-analysis and its software tools – the system of "Eidos"

  14. Impacto da estocagem sobre atividade antioxidante e teor de ácido ascórbico em sucos e refrescos de tangerina

    Directory of Open Access Journals (Sweden)

    Carolina Ferraz Figueiredo Moreira

    2012-12-01

    Full Text Available OBJETIVO: Objetivou-se avaliar a estabilidade do ácido ascórbico em suco in natura de tangerina cultivar Ponkan sob diferentes condições de armazenamento, e em 13 amostras de bebidas industrializadas de tangerina, bem como a estabilidade da atividade antioxidante no suco in natura. MÉTODOS: O suco in natura de tangerina foi armazenado em três temperaturas: ambiente, refrigeração e congelamento. Amostras de tangerinas foram armazenadas sob refrigeração. Treze marcas de bebidas industrializadas de tangerina foram adquiridas e mantidas sob refrigeração. Foram determinados o teor de ácido ascórbico pelo método titulométrico de Tillmans (Association of Official Analytical Chemists e a atividade antioxidante por meio da capacidade sequestradora do radical 2,2-difenil-1-picril-hidrazila. RESULTADOS: O suco in natura apresentou teor médio de ácido ascórbico de 32,40mg/100mL; a taxa de redução deste nutriente foi maior em temperatura de estocagem mais elevada. A atividade antioxidante média foi de 89,74% de inibição do radical 2,2-difenil-1-picril-hidrazila, apresentando variações de até 4,26% durante o armazenamento. Nas bebidas industrializadas, o teor médio de ácido ascórbico variou entre 1,01 e 10,72mg/100mL, com perdas de até 82,76%. Com base na legislação brasileira, seis marcas de bebidas industrializadas apresentaram não conformidades em relação à declaração do teor de ácido ascórbico nos rótulos. CONCLUSÃO: O suco de tangerina cultivar Ponkan apresenta elevada atividade antioxidante, inclusive durante o armazenamento. Observou-se superioridade nutricional do suco fresco em comparação às bebidas industrializadas, considerando o teor de ácido ascórbico e sua estabilidade. Adicionalmente, os dados obtidos apontam para a necessidade de maior fiscalização em relação à rotulagem nutricional.

  15. The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.

    Directory of Open Access Journals (Sweden)

    Fabio Carrilho Galvão

    Full Text Available The putative eukaryotic translation initiation factor 5A (eIF5A is a highly conserved protein among archaea and eukaryotes that has recently been implicated in the elongation step of translation. eIF5A undergoes an essential and conserved posttranslational modification at a specific lysine to generate the residue hypusine. The enzymes deoxyhypusine synthase (Dys1 and deoxyhypusine hydroxylase (Lia1 catalyze this two-step modification process. Although several Saccharomyces cerevisiae eIF5A mutants have importantly contributed to the study of eIF5A function, no conditional mutant of Dys1 has been described so far. In this study, we generated and characterized the dys1-1 mutant, which showed a strong depletion of mutated Dys1 protein, resulting in more than 2-fold decrease in hypusine levels relative to the wild type. The dys1-1 mutant demonstrated a defect in total protein synthesis, a defect in polysome profile indicative of a translation elongation defect and a reduced association of eIF5A with polysomes. The growth phenotype of dys1-1 mutant is severe, growing only in the presence of 1 M sorbitol, an osmotic stabilizer. Although this phenotype is characteristic of Pkc1 cell wall integrity mutants, the sorbitol requirement from dys1-1 is not associated with cell lysis. We observed that the dys1-1 genetically interacts with the sole yeast protein kinase C (Pkc1 and Asc1, a component of the 40S ribosomal subunit. The dys1-1 mutant was synthetically lethal in combination with asc1Δ and overexpression of TIF51A (eIF5A or DYS1 is toxic for an asc1Δ strain. Moreover, eIF5A is more associated with translating ribosomes in the absence of Asc1 in the cell. Finally, analysis of the sensitivity to cell wall-perturbing compounds revealed a more similar behavior of the dys1-1 and asc1Δ mutants in comparison with the pkc1Δ mutant. These data suggest a correlated role for eIF5A and Asc1 in coordinating the translational control of a subset of m

  16. The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.

    Science.gov (United States)

    Galvão, Fabio Carrilho; Rossi, Danuza; Silveira, Wagner da Silva; Valentini, Sandro Roberto; Zanelli, Cleslei Fernando

    2013-01-01

    The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein among archaea and eukaryotes that has recently been implicated in the elongation step of translation. eIF5A undergoes an essential and conserved posttranslational modification at a specific lysine to generate the residue hypusine. The enzymes deoxyhypusine synthase (Dys1) and deoxyhypusine hydroxylase (Lia1) catalyze this two-step modification process. Although several Saccharomyces cerevisiae eIF5A mutants have importantly contributed to the study of eIF5A function, no conditional mutant of Dys1 has been described so far. In this study, we generated and characterized the dys1-1 mutant, which showed a strong depletion of mutated Dys1 protein, resulting in more than 2-fold decrease in hypusine levels relative to the wild type. The dys1-1 mutant demonstrated a defect in total protein synthesis, a defect in polysome profile indicative of a translation elongation defect and a reduced association of eIF5A with polysomes. The growth phenotype of dys1-1 mutant is severe, growing only in the presence of 1 M sorbitol, an osmotic stabilizer. Although this phenotype is characteristic of Pkc1 cell wall integrity mutants, the sorbitol requirement from dys1-1 is not associated with cell lysis. We observed that the dys1-1 genetically interacts with the sole yeast protein kinase C (Pkc1) and Asc1, a component of the 40S ribosomal subunit. The dys1-1 mutant was synthetically lethal in combination with asc1Δ and overexpression of TIF51A (eIF5A) or DYS1 is toxic for an asc1Δ strain. Moreover, eIF5A is more associated with translating ribosomes in the absence of Asc1 in the cell. Finally, analysis of the sensitivity to cell wall-perturbing compounds revealed a more similar behavior of the dys1-1 and asc1Δ mutants in comparison with the pkc1Δ mutant. These data suggest a correlated role for eIF5A and Asc1 in coordinating the translational control of a subset of mRNAs associated with cell

  17. ADAPTIVE SYNTHESIS OF INTELLIGENT MEASUREMENT SYSTEMS WITH THE USE OF ASC-ANALYSIS AND "EIDOS" SYSTEM. SYSTEM IDENTIFICATION IN ECONOMETRICS, BIOMETRICS, ECOLOGY, PEDAGOGY, PSYCHOLOGY AND MEDICINE

    Directory of Open Access Journals (Sweden)

    Lutsenko Y. V.

    2016-02-01

    Full Text Available The article proposes using the automated system-cognitive analysis (ASC-analysis and its software tool, which is the system called "Eidos" for synthesis and application of adaptive intelligent measuring systems to measure values of parameters of objects, and for system state identification of complex multivariable nonlinear dynamic systems. The article briefly describes the mathematical method of ASC-analysis, implemented in the software tool – universal cognitive analytical system named "Eidos-X++". The mathematical method of ASC-analysis is based on system theory of information (STI which was created in the conditions of implementation of program ideas of generalizations of all the concepts of mathematics, in particularly, the information theory based on the set theory, through a total replacement of the concept of “many” with the more general concept of system and detailed tracking of all the consequences of this replacement. Due to the mathematical method, which is the basis of ASC-analysis, this method is nonparametric and allows you to process comparably tens and hundreds of thousands of gradations of factors and future conditions of the control object (class in incomplete (fragmented, noisy data numeric and non-numeric nature which are measured in different units of measurement. We provide a detailed numerical example of the application of ASC-analysis and the system of "Eidos-X++" as a synthesis of systemic-cognitive model, providing a multiparameter typization of the states of complex systems, and system identification of their states, as well as for making decisions about managing the impact of changing the composition of the control object to get its quality (level of consistency maximally increased at minimum cost. For a numerical example of a complex system we have selected the team of the company, and its component – employees and applicants (staff. However, it must be noted that this example should be considered even wider

  18. 7 CFR Exhibit A to Subpart A of... - Notice to FmHA or its successor agency under Public Law 103-354 Borrowers

    Science.gov (United States)

    2010-01-01

    ... Part 1951—Notice to FmHA or its successor agency under Public Law 103-354 Borrowers FmHA or its successor agency under Public Law 103-354 borrowers with farmer program and community program loan types... statements through their local FmHA or its successor agency under Public Law 103-354 office....

  19. En Francais dans le texte: etude des emprunts francais en anglo-americain (In French in the Text: Study of French Borrowing in Anglo-American).

    Science.gov (United States)

    Otman, Gabriel

    1989-01-01

    Analysis of the linguistic borrowing from French of American newspapers looks at the areas where vocabulary is borrowed and stereotypes are perpetuated. The alterations made in French expressions, as a result of ignorance or in order to suit American habits, are examined. (MSE)

  20. 7 CFR Appendix C to Subpart C of... - FSA-2514, Notice of Availability of Loan Servicing to Borrowers Who Are in Non-Monetary Default

    Science.gov (United States)

    2010-01-01

    ... Borrowers Who Are in Non-Monetary Default C Appendix C to Subpart C of Part 766 Agriculture Regulations of... PROGRAMS DIRECT LOAN SERVICING-SPECIAL Loan Servicing Programs Pt. 766, Subpt. C, App. C Appendix C to Subpart C of Part 766—FSA-2514, Notice of Availability of Loan Servicing to Borrowers Who Are in...

  1. 7 CFR Exhibit B-2 to Subpart B of... - Letter for Notifying Applicants, Lenders and Holders and Borrowers of Unfavorable Decision...

    Science.gov (United States)

    2010-01-01

    ... and Borrowers of Unfavorable Decision Reached at the Meeting B Exhibit B-2 to Subpart B of Part 1900... REGULATIONS GENERAL Adverse Decisions and Administrative Appeals Pt. 1900, Subpt. B, Exh. B-2 Exhibit B-2 to Subpart B of Part 1900—Letter for Notifying Applicants, Lenders and Holders and Borrowers of...

  2. 7 CFR Exhibit B-1 to Subpart B of... - Letter for Notifying Applicants, Lender, Holders and Borrowers of Adverse Decisions Where the...

    Science.gov (United States)

    2010-01-01

    ... Borrowers of Adverse Decisions Where the Decision Is Appealable B Exhibit B-1 to Subpart B of Part 1900... REGULATIONS GENERAL Adverse Decisions and Administrative Appeals Pt. 1900, Subpt. B, Exh. B-1 Exhibit B-1 to Subpart B of Part 1900—Letter for Notifying Applicants, Lender, Holders and Borrowers of Adverse...

  3. 7 CFR 1717.657 - Investments above the 15 percent level by certain borrowers not exempt under § 1717.656(a).

    Science.gov (United States)

    2010-01-01

    ... AND PROCEDURES COMMON TO INSURED AND GUARANTEED ELECTRIC LOANS Investments, Loans, and Guarantees by Electric Borrowers § 1717.657 Investments above the 15 percent level by certain borrowers not exempt under... required to perform for the entire amount of the guarantee. These risks will be considered along with...

  4. The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons

    Science.gov (United States)

    Ehmsen, Jeffrey T.; Liu, Yong; Wang, Yue; Paladugu, Nikhil; Johnson, Anna E.; Rothstein, Jeffrey D.; du Lac, Sascha; Mattson, Mark P.; Höke, Ahmet

    2016-01-01

    SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutamatergic neurotransmission. We find that SLC7A10 is substantially enriched in a subset of astrocytes of the caudal brain and spinal cord in a distribution corresponding with high densities of glycinergic inhibitory synapses. Accordingly, we find that spinal cord glycine levels are significantly reduced in Slc7a10-null mice and spontaneous glycinergic postsynaptic currents in motor neurons show substantially diminished amplitudes, demonstrating an essential role for SLC7A10 in glycinergic inhibitory function in the central nervous system. These observations establish the etiology of sustained myoclonus (sudden involuntary muscle movements) and early postnatal lethality characteristic of Slc7a10-null mice, and implicate SLC7A10 as a candidate gene and auto-antibody target in human hyperekplexia and stiff person syndrome, respectively. PMID:27759100

  5. Transcriptional signature of human adipose tissue-derived stem cells (hASCs) preconditioned for chondrogenesis in hypoxic conditions

    Energy Technology Data Exchange (ETDEWEB)

    Pilgaard, L.; Lund, P.; Duroux, M. [Laboratory for Stem Cell Research, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg (Denmark); Lockstone, H.; Taylor, J. [Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, OX3 7BN (United Kingdom); Emmersen, J.; Fink, T. [Laboratory for Stem Cell Research, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg (Denmark); Ragoussis, J. [Genomics, Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, OX3 7BN (United Kingdom); Zachar, V., E-mail: vlaz@hst.aau.dk [Laboratory for Stem Cell Research, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg (Denmark)

    2009-07-01

    Hypoxia is an important factor involved in the control of stem cells. To obtain a better insight into the phenotypical changes brought about by hypoxic preconditioning prior to chondrogenic differentiation; we have investigated growth, colony-forming and chondrogenic capacity, and global transcriptional responses of six adipose tissue-derived stem cell lines expanded at oxygen concentrations ranging from ambient to 1%. The assessment of cell proliferation and colony-forming potential revealed that the hypoxic conditions corresponding to 1% oxygen played a major role. The chondrogenic inducibility, examined by high-density pellet model, however, did not improve on hypoxic preconditioning. While the microarray analysis revealed a distinctive inter-donor variability, the exposure to 1% hypoxia superseded the biological variability and produced a specific expression profile with 2581 significantly regulated genes and substantial functional enrichment in the pathways of cell proliferation and apoptosis. Additionally, exposure to 1% oxygen resulted in upregulation of factors related to angiogenesis and cell growth. In particular, leptin (LEP), the key regulator of body weight and food intake was found to be highly upregulated. In conclusion, the results of this investigation demonstrate the significance of donor demographics and the importance of further studies into the use of regulated oxygen tension as a tool for preparation of ASCs in order to exploit their full potential.

  6. Observing Strategies Used by Children When Selecting Books to Browse, Read or Borrow

    Directory of Open Access Journals (Sweden)

    Syahranah A. Raqi

    2008-06-01

    Full Text Available This paper described 1. the investigation undertaken to trace the strategies used by children in selecting books to borrow, use or browse in two children’s public libraries, and 2. map the information seeking patterns adopted by the selected children. The sample comprised 43 children who used the Bayan Budiman Children’s Library, Petaling Jaya and the Kuala Lumpur Children’s Library. The children were randomly chosen, aged between 7 and 12 and comprised those who entered the library with the observed behaviour of selecting books to browse, use or borrow. Two stages were used to collect data; 1. observing the children’s behavior as they enter the library to the point when they pick up a book to browse, read or borrow for fifteen to twenty minutes and 2. interviewing those selected with a semi-structure questionnaire. Belkin, et al’s (1993 information search strategy (ISS dimensions were used to transcribe children’s browsing and selecting behavior. Based on the observations and interviews respondent’s behaviour was mapped to illustrate the children’s choosing process. The findings indicated that 1. browsing was the most popular method used when choosing a book combined with various strategies such as looking for a book by an author or series, finding a book by subjects, visually or physically scanning and recognizing the physical composition of the book; 2. children based their selection on the storyline, illustrations, cover designs and typography of the books; and 3. the searching behaviour is likely to be non-linear in nature. The majority of the children faced no problems in choosing or locating a book as most are regular visitors. A few indicated being overwhelmed by the library’s large collection or, face initial confusion before they started to browse and interact with resources. Children used visual cues rather from textual information when searching for books, inferring that children libraries need to be supported with

  7. Network protocol changes can improve DisCom WAN performance : evaluating TCP modifications and SCTP in the ASC tri-lab environment.

    Energy Technology Data Exchange (ETDEWEB)

    Tolendino, Lawrence F.; Hu, Tan Chang

    2005-06-01

    The Advanced Simulation and Computing (ASC) Distance Computing (DisCom) Wide Area Network (WAN) is a high performance, long distance network environment that is based on the ubiquitous TCP/IP protocol set. However, the Transmission Control Protocol (TCP) and the algorithms that govern its operation were defined almost two decades ago for a network environment vastly different from the DisCom WAN. In this paper we explore and evaluate possible modifications to TCP that purport to improve TCP performance in environments like the DisCom WAN. We also examine a much newer protocol, SCTP (Stream Control Transmission Protocol) that claims to provide reliable network transport while also implementing multi-streaming, multi-homing capabilities that are appealing in the DisCom high performance network environment. We provide performance comparisons and recommendations for continued development that will lead to network communications protocol implementations capable of supporting the coming ASC Petaflop computing environments.

  8. A Public Choice Approach to the Unequal Treatment of Securities Market Participants and Home Borrowers

    Directory of Open Access Journals (Sweden)

    Jonathan Macey

    2017-01-01

    Full Text Available This article contrasts the protections provided to participants in U.S. securities markets with the protections provided to participants in the U.S. mortgage markets. Participants in securities markets purchase and sell equity and debt securities. Participants in the mortgage markets borrow money to buy homes, using those homes as collateral for the mortgage loans they receive. Even after Dodd-Frank, participants in securities markets are afforded significantly higher levels of protection than participants in mortgage markets. The doctrine of suitability is a prime example of this inequity. Exploring possible explanations for this odd asymmetry of treatment, I conclude that interest group politics is to blame for the anomaly.

  9. Conversion of alcohols to enantiopure amines through dual enzyme hydrogen-borrowing cascades

    Science.gov (United States)

    Mutti, Francesco G.; Knaus, Tanja; Scrutton, Nigel S.; Breuer, Michael; Turner, Nicholas J.

    2016-01-01

    α-Chiral amines are key intermediates for the synthesis of a plethora of chemical compounds on industrial scale. Here we present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows for the efficient and environmentally benign production of enantiopure amines. The method relies on the combination of an alcohol dehydrogenase (ADHs from Aromatoleum sp., Lactobacillus sp. and Bacillus sp.) enzyme operating in tandem with an amine dehydrogenase (AmDHs engineered from Bacillus sp.) to aminate a structurally diverse range of aromatic and aliphatic alcohols (up to 96% conversion and 99% enantiomeric excess). Furthermore, primary alcohols are aminated with high conversion (up to 99%). This redox self-sufficient network possesses high atom efficiency, sourcing nitrogen from ammonium and generating water as the sole by-product. PMID:26404833

  10. Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

    Science.gov (United States)

    Mutti, Francesco G; Knaus, Tanja; Scrutton, Nigel S; Breuer, Michael; Turner, Nicholas J

    2015-09-25

    α-Chiral amines are key intermediates for the synthesis of a plethora of chemical compounds at industrial scale. We present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows for the efficient and environmentally benign production of enantiopure amines. The method relies on a combination of two enzymes: an alcohol dehydrogenase (from Aromatoleum sp., Lactobacillus sp., or Bacillus sp.) operating in tandem with an amine dehydrogenase (engineered from Bacillus sp.) to aminate a structurally diverse range of aromatic and aliphatic alcohols, yielding up to 96% conversion and 99% enantiomeric excess. Primary alcohols were aminated with high conversion (up to 99%). This redox self-sufficient cascade possesses high atom efficiency, sourcing nitrogen from ammonium and generating water as the sole by-product.

  11. Networks of lexical borrowing and lateral gene transfer in language and genome evolution.

    Science.gov (United States)

    List, Johann-Mattis; Nelson-Sathi, Shijulal; Geisler, Hans; Martin, William

    2014-02-01

    Like biological species, languages change over time. As noted by Darwin, there are many parallels between language evolution and biological evolution. Insights into these parallels have also undergone change in the past 150 years. Just like genes, words change over time, and language evolution can be likened to genome evolution accordingly, but what kind of evolution? There are fundamental differences between eukaryotic and prokaryotic evolution. In the former, natural variation entails the gradual accumulation of minor mutations in alleles. In the latter, lateral gene transfer is an integral mechanism of natural variation. The study of language evolution using biological methods has attracted much interest of late, most approaches focusing on language tree construction. These approaches may underestimate the important role that borrowing plays in language evolution. Network approaches that were originally designed to study lateral gene transfer may provide more realistic insights into the complexities of language evolution.

  12. Borrowed knowledge chaos theory and the challenge of learning across disciplines

    CERN Document Server

    Kellert, Stephen H

    2009-01-01

    What happens to scientific knowledge when researchers outside the natural sciences bring elements of the latest trend across disciplinary boundaries for their own purposes? Researchers in fields from anthropology to family therapy and traffic planning employ the concepts, methods, and results of chaos theory to harness the disciplinary prestige of the natural sciences, to motivate methodological change or conceptual reorganization within their home discipline, and to justify public policies and aesthetic judgments.Using the recent explosion in the use (and abuse) of chaos theory, Borrowed Knowledge and the Challenge of Learning across Disciplines examines the relationship between science and other disciplines as well as the place of scientific knowledge within our broader culture. Stephen H. Kellert's detailed investigation of the myriad uses of chaos theory reveals serious problems that can arise in the interchange between science and other knowledge-making pursuits, as well as opportunities for constructive...

  13. Reflections on Asia: Borrowing Lessons from the Humanities in Social Science Coursework

    Directory of Open Access Journals (Sweden)

    Howard Sanborn

    2017-07-01

    Full Text Available What lessons can political science classes borrow from the humanities? This paper presents the results of a multi-year study on teaching about Asia as part of a general education program. Given the challenges of meeting common learning outcomes while also teaching discipline-specific lessons, political science courses often underperformed in assessments when compared to benchmark expectations. While our initial conclusion—that a greater focus on multimodal assignments would promote deeper learning and reflection—proved unfounded, explicitly emphasizing students’ reflection on their own process of democratic engagement, in comparison to that of their counterparts in Asia, did seem to address the shortcomings of the previous approaches by giving students context and guidance in their understanding of how democracy works at home and abroad. Data from reflective essays, collected over two years, provide evidence for this finding.

  14. Maurice Gee's Brilliant Borrowings of Maurice Gee and Significant Others: Realism and Postmodernism in Gee's Books for Children and Adults

    Science.gov (United States)

    van Rij, Vivien

    2013-01-01

    This paper examines the work of one of New Zealand's most acclaimed writers, Maurice Gee, and the use of his children's fiction as an experimental ground for postmodernist techniques further developed in his writing for adults. In particular, it considers Gee's borrowings of his own and others' non-fictional and fictional material, to produce…

  15. Screening in new credit markets: can individual lenders infer borrower creditworthiness in peer-to-peer lending?

    NARCIS (Netherlands)

    Iyer, R.; Khwaja, A.I.; Luttmer, E.F.P.; Shue, K.

    2009-01-01

    The current banking crisis highlights the challenges faced in the traditional lending model, particularly in terms of screening smaller borrowers. The recent growth in online peer-to-peer lending marketplaces offers opportunities to examine different lending models that rely on screening by multiple

  16. Thoughts on Library Books Online Borrow%图书馆在线借书问题的思考

    Institute of Scientific and Technical Information of China (English)

    曹静

    2011-01-01

    文章针对在线借阅图书这一问题,首先,建立0—1整数规划的数学模型,给出了在线借阅图书系统最优购置图书以及最优分配图书的具体方案;其次,在假定在线图书馆每一年借阅图书的比例保持不变的前提下预测出了图书借阅量;最后,根据调查数据,应用具体的算例对此模型进行了检验.%As for library books online borrow, first, the paper advances the mathematical model based on the 0-1 integer programming, and the system suggests the optimal books online borrow the best optimal distribution; secondly, it predicates the volumes of the books online borrow, supposing there is no change of ratio in books online borrowing; finally, according to the survey data, the application of concrete examples of this model is tested.

  17. 7 CFR Appendix C to Subpart B of... - Statement, Certification, and Agreement of Borrower's President of Board of Directors Regarding...

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Statement, Certification, and Agreement of Borrower's President of Board of Directors Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(d) C Appendix C to... INSURED TELEPHONE LOANS Lien Accommodations and Subordination Policy Pt. 1744, Subpt. B, App. C Appendix...

  18. Efecto de la densidad de siembra y la adición de ácido ascórbico en el cultivo de Osteoglossum bicirrhosum

    Directory of Open Access Journals (Sweden)

    Carolina Cuaical T.

    2013-11-01

    Full Text Available Objetivo. Evaluar el efecto de la densidad de siembra y la adición de ácido ascórbico en la alimentación de alevinos de O. bicirrhosum, cultivados en jaulas. Materiales y métodos. Se incluyeron 396 alevinos y se distribuyeron en nueve tratamientos, resultado de la combinación de los niveles del factor densidad de siembra: 1pez/5 L; 1pez/10 L y 1pez/15 L y los niveles de ácido ascórbico: 0; 500 y 1000 mg/kg. Los datos obtenidos se evaluaron mediante el análisis de varianza del diseño factorial 32. Resultados. La densidad de siembra presentó diferencias estadísticas significativas en el incremento de peso. Las variables incremento de longitud y tasa de crecimiento específico no presentaron diferencias estadísticas. En cuanto a la conversión alimenticia aparente, se demostraron diferencias significativas en los dos factores: La densidad de 1pez/10 L indicó la mejor conversión con un valor de 1.50, asimismo, la inclusión de 1000 mg de ácido ascórbico por Kg de alimento mostró los mejores promedios con 1.55. En la sobrevivencia se precisaron diferencias estadísticas entre los tratamientos de la densidad de 1pez/5 L, siendo mejores aquellos que incluyeron ácido ascórbico en la dieta. Conclusiones. La densidad de 1pez/10 L registró el mayor incremento de peso con 31.83 g en 87 días. La sobrevivencia general fue del 96%, lo que demuestra la eficiencia del sistema de cultivo utilizado, al tiempo que actúa de manera positiva en el desarrollo de esta especie.

  19. ASC-J9 Suppresses Castration-Resistant Prostate Cancer Growth through Degradation of Full-length and Splice Variant Androgen Receptors

    Directory of Open Access Journals (Sweden)

    Shinichi Yamashita

    2012-01-01

    Full Text Available Early studies suggested androgen receptor (AR splice variants might contribute to the progression of prostate cancer (PCa into castration resistance. However, the therapeutic strategy to target these AR splice variants still remains unresolved. Through tissue survey of tumors from the same patients before and after castration resistance, we found that the expression of AR3, a major AR splice variant that lacks the AR ligand-binding domain, was substantially increased after castration resistance development. The currently used antiandrogen, Casodex, showed little growth suppression in CWR22Rv1 cells. Importantly, we found that AR degradation enhancer ASC-J9 could degrade both full-length (fAR and AR3 in CWR22Rv1 cells as well as in C4-2 and C81 cells with addition of AR3. The consequences of such degradation of both fAR and AR3 might then result in the inhibition of AR transcriptional activity and cell growth in vitro. More importantly, suppression of AR3 specifically by short-hairpin AR3 or degradation of AR3 by ASC-J9 resulted in suppression of AR transcriptional activity and cell growth in CWR22Rv1-fARKD (fAR knockdown cells in which DHT failed to induce, suggesting the importance of targeting AR3. Finally, we demonstrated the in vivo therapeutic effects of ASC-J9 by showing the inhibition of PCa growth using the xenografted model of CWR22Rv1 cells orthotopically implanted into castrated nude mice with undetectable serum testosterone. These results suggested that targeting both fAR- and AR3-mediated PCa growth by ASC-J9 may represent the novel therapeutic approach to suppress castration-resistant PCa. Successful clinical trials targeting both fAR and AR3 may help us to battle castration-resistant PCa in the future.

  20. Jet Formation Mechanism Contrast Between ASC and LSC%环型与线型聚能装药射流成型机理对比

    Institute of Scientific and Technical Information of China (English)

    傅磊; 王伟力; 吕进; 李永胜

    2014-01-01

    Asymmetry exists during the process of jet formation of Annular shaped charge (ASC) liner, and the existing theo-ry on the linear shaped charge (LSC) jet formation cannot be used directly. DNYA 3D software was used to simulate the jet formation process of ASC and LSC with the structure of same section. Through contrast, the slug and jet parameter charac-teristics of ASC were analyzed, and it might provide reference to the theoretical research and engineering application.%环型聚能装药药型罩2侧在挤压汇聚形成射流过程中存在不对称性,不能完全套用线型聚能装药射流成型的现有理论。利用DYNA3D软件对相同剖面结构的环型、线型聚能装药射流成型过程进行数值模拟,通过比较分析得出了环型聚能装药形成杵体及射流参数的分布特性,为进一步理论研究及工程应用提供参考。

  1. Problems and prospects of modern methods of business analysis in the process of assessment of solvency of borrowers

    Directory of Open Access Journals (Sweden)

    Aptekar Saveliy S.

    2013-03-01

    Full Text Available The goal of the article is a comparative analysis of modern methods of business analysis in the process of assessment of solvency of borrowers of Ukrainian commercial banks, study of prospects and problems of the use of methods in the credit process. In the result of the study the article systemises and considers the conduct of the credit process of Ukrainian commercial banks. It becomes clear from result of the study that it is impossible to obtain a single assessment of solvency of a borrower with generalisation of numerical and non-numerical data. Assessment of qualified analysts is required for a justified assessment of solvency apart from information represented in numbers. Improvement of approaches to assessment of solvency of borrowers and adaptation of the existing foreign experience in this field to specific features of formation of solvency of Ukrainian borrowers are important tasks for the Ukrainian banking system. Prospects of further studies in this direction are establishment of importance of the conduct of business analysis and its key role in assessment of solvency of borrowers as a main instrument of minimisation of the credit risk. Improvement of this sphere of analytical work in Ukrainian banks should be carried out in the following main directions: study and analysis of qualitative indicators of business activity; analysis of main sections of the business plan; expansion of the composition of indicators of the financial analysis for obtaining information; conduct of analysis of possible sources of repayment of loan liabilities; and active use of analysis of cash flows of an enterprise.

  2. An Analysis of MENG's Hexagon View Borrowing Theory%试析孟氏六边形借景理法

    Institute of Scientific and Technical Information of China (English)

    顾孟潮

    2014-01-01

    被《园冶》作者计成称为“园林之最要者的”“借景”则是最能体现中国人习惯、生活,即追求“诗意栖居”的华夏意匠。孟氏六边形借景理法是借鉴古今园林经验创制的借景理法新篇,它源于《园冶》又高于《园冶》。作者从理法由来、理法创新、设计思维、环境艺术4个角度论述孟氏借景理法的理论价值和实践意义,指出它将促进园林设计理论和实践水平整体提升。%"View borrowing", which is considered “the most important element in gardens” by JI Chen, the author of Yuan Ye, is the best reflection of Chinese people's way of life, which is the pursuit for a poetic living. MENG’s Hexagon View Borrowing Theory is an innovative garden design theory based on the reference of ancient and modern garden design experience. It derives fromYuan Ye but it is more than justYuan Ye. The author tries to discuss the theoretical value and practical significance of MENG’s view borrowing theory from the aspects of the origin of view borrowing method, the innovation of view borrowing method, design thinking and environmental art, pointing out that it is beneficial for the improvement of the theory and practice of garden design.

  3. Anglicisms in the Romanian business and technology vocabulary

    Science.gov (United States)

    Todea, L.; Demarcsek, R.

    2016-08-01

    Multinational companies in Romania have imposed the use of the predominant language, in most cases - English, in professional communication. In contexts related to workplace communication, the main motivation for foreign borrowings is the need to denote concepts and activities. The article focuses on the English language as a wide source for a great number of innovations both at the lexical and the morphological level in the Romanian vocabulary related to business and technology. The aim of the paper is to demonstrate that Romanian language displays a natural disposition towards adopting and adapting foreign words, especially borrowed English terms, in the field of computer science and business without endangering its identity.

  4. The Accuracy of p16/Ki-67 and HPV Test in the Detection of CIN2/3 in Women Diagnosed with ASC-US or LSIL.

    Directory of Open Access Journals (Sweden)

    Júlio C Possati-Resende

    Full Text Available The objective of this study was to compare the accuracies of double staining for p16/Ki-67 and the molecular test for high-risk HPV (hr-HPV to identify high-grade cervical intraepithelial neoplasia (CIN2/CIN3 in women with cervical cytology of atypical squamous cells of undetermined significance (ASC-US and low-grade squamous intraepithelial lesion (LSIL. Data were collected from 201 women who underwent cervical cytology screening in the Barretos Cancer Hospital and their results were categorized as ASC-US (n=96 or LSIL (n=105. All patients underwent colposcopy with or without cervical biopsy for diagnosis of CIN2/CIN3. The hr-HPV test (Cobas 4800 test and immunocytochemistry were performed to detect biomarkers p16/Ki-67 (CINtec PLUS test. Two samples (1 ASC-US/1 LSIL were excluded from the analysis due to inconclusive results of the histologic examination. There were 8 cases of CIN2/CIN3 among 95 women with ASC-US (8.4%, and 23 cases of CIN2/CIN3 among 104 women with LSIL (22.1%. In the group of women with ASC-US, the sensitivity and specificity in diagnosing CIN2/CIN3 were 87.5% and 79.5% for the HPV test and 62.5% and 93.1% for p16/Ki-67. Among women with LSIL, the sensitivity and specificity in the diagnosis of CIN2/CIN3 were 87% and 34.7% for the HPV test and 69.6% and 75.3% for immunocytochemistry. Superior performance was observed for p16/Ki-67 double staining, especially among women under 30 for whom the test had an area under the ROC curve of 0.762 (p30 years. In younger women (≤30 years with LSIL, p16/Ki-67 had greater accuracy in identifying precursor lesions. Among women >30 years diagnosed with LSIL, the two methods showed similar performance.

  5. Report of experiments and evidence for ASC L2 milestone 4467 : demonstration of a legacy application's path to exascale.

    Energy Technology Data Exchange (ETDEWEB)

    Curry, Matthew L.; Ferreira, Kurt Brian; Pedretti, Kevin Thomas Tauke; Leung, Vitus Joseph; Moreland, Kenneth D.; Lofstead, Gerald Fredrick, II; Gentile, Ann C. (Sandia National Laboratories, Livermore, CA); Klundt, Ruth Ann; Ward, H. Lee; Laros, James H., III; Hemmert, Karl Scott; Fabian, Nathan D.; Levenhagen, Michael J.; Barrett, Brian W.; Brightwell, Ronald Brian; Barrett, Richard; Wheeler, Kyle Bruce; Kelly, Suzanne Marie; Rodrigues, Arun F.; Brandt, James M. (Sandia National Laboratories, Livermore, CA); Thompson, David (Sandia National Laboratories, Livermore, CA); VanDyke, John P.; Oldfield, Ron A.; Tucker, Thomas (Open Grid Computing, Inc., Austin, TX); Vaughan, Courtenay Thomas

    2012-03-01

    This report documents thirteen of Sandia's contributions to the Computational Systems and Software Environment (CSSE) within the Advanced Simulation and Computing (ASC) program between fiscal years 2009 and 2012. It describes their impact on ASC applications. Most contributions are implemented in lower software levels allowing for application improvement without source code changes. Improvements are identified in such areas as reduced run time, characterizing power usage, and Input/Output (I/O). Other experiments are more forward looking, demonstrating potential bottlenecks using mini-application versions of the legacy codes and simulating their network activity on Exascale-class hardware. The purpose of this report is to prove that the team has completed milestone 4467-Demonstration of a Legacy Application's Path to Exascale. Cielo is expected to be the last capability system on which existing ASC codes can run without significant modifications. This assertion will be tested to determine where the breaking point is for an existing highly scalable application. The goal is to stretch the performance boundaries of the application by applying recent CSSE RD in areas such as resilience, power, I/O, visualization services, SMARTMAP, lightweight LWKs, virtualization, simulation, and feedback loops. Dedicated system time reservations and/or CCC allocations will be used to quantify the impact of system-level changes to extend the life and performance of the ASC code base. Finally, a simulation of anticipated exascale-class hardware will be performed using SST to supplement the calculations. Determine where the breaking point is for an existing highly scalable application: Chapter 15 presented the CSSE work that sought to identify the breaking point in two ASC legacy applications-Charon and CTH. Their mini-app versions were also employed to complete the task. There is no single breaking point as more than one issue was found with the two codes. The results were

  6. ELECTRONIC VOTING AS A FORM OF THE ELECTORAL INFORMATION AND COMMUNICATION TECHNOLOGIES: FOREIGN AND DOMESTIC EXPERIENCE

    OpenAIRE

    2015-01-01

    Electronic voting is considered in the context of information and communication technologies used during the electoral process. The foreign experience in implementing the e-voting technologies and prospects of its borrowings for use in Ukraine is analized. The basic advantages and disadvantages of electronic voting is underlined.

  7. ASC Weekly News Notes

    Energy Technology Data Exchange (ETDEWEB)

    Womble, David E.

    2016-05-01

    Unified collision operator demonstrated for both radiation transport and PIC-DSMC. A side-by-side comparison between the DSMC method and the radiation transport method was conducted for photon attenuation in the atmosphere over 2 kilometers in physical distance with a reduction of photon density of six orders of magnitude. Both DSMC and traditional radiation transport agreed with theory to two digits. This indicates that PIC-DSMC operators can be unified with the radiation transport collision operators into a single code base and that physics kernels can remain unique to the actual collision pairs. This simulation example provides an initial validation of the unified collision theory approach that will later be implemented into EMPIRE.

  8. Ecological succession and its impact on malaria vectors and their predators in borrow pits in western Ethiopia.

    Science.gov (United States)

    Kiszewski, Anthony E; Teffera, Zelalem; Wondafrash, Melaku; Ravesi, Michael; Pollack, Richard J

    2014-12-01

    Soil pits excavated for home construction are important larval habitats for malaria vectors in certain parts of Africa. Borrow pits in diverse stages of ecological succession in a maize-farming region of Western Ethiopia were surveyed to assess the relationships between stage of succession and the structure and composition of invertebrate and plant communities, with particular attention to Anopheles gambiae s.l. and An. coustani, the primary local malaria vectors. An array of 82 borrow pits was identified in a multi-lobed drainage basin in the community of Woktola. Each pit was evaluated on its physical features and by faunal and floral surveys during August, 2011, at the height of the longer rainy season (kiremt). Anopheles gambiae s.l. and An. coustani were the sole immature anophelines collected, often coexisting with Culex spp. Sedges were the most common plants within these pits, and included Cyperus elegantulus, C. flavescens, C. erectus and C. assimilis. The legume Smithia abyssinica, Nile grass (Acroceras macrum), cutgrass (Leersia hexandra), clover (Trifolium spp.), and the edible herb Centella asiatica, were also common in these habitats. No plant species in particular was strongly and consistently predictive of the presence or absence of mosquito immatures, particularly with regard to An. coustani. The presence of An.gambiae s.l. immatures in borrow pit habitats was negatively correlated with the presence of backswimmers (Notonectidae) (Z = -2.34, P = 0.019). Young (freshly excavated) borrow pits more likely contained immature An. gambiae s.l. (Z =-2.86, P=0.004). Ecological succession was apparent in older pits, and as they aged, they became less likely to serve as habitats for An. gambiae s.l. (Z=0.26, P=0.796), and more likely to support An. coustani (Z=0.728, P=0.007). As borrow pits age they become less suitable for An. gambiae s.l. breeding and more likely to harbor An. coustani. The abundance of notonectids in habitats was a negative indicator for

  9. Efeitos do ácido ascórbico nos biomarcadores de estresse oxidativo em nadadores de elite

    Directory of Open Access Journals (Sweden)

    Monike Garlipp-Picchi

    2013-12-01

    Full Text Available OBJETIVO: O objetivo do estudo foi verificar os efeitos da oferta de vitamina C através de um suplemento alimentar e dieta rica em ácido ascórbico (AA no estresse oxidativo induzido pelo exercício. MÉTODOS: A amostra foi composta por 13 nadadores de elite (seis homens e sete mulheres com idades entre 18 e 26 anos. Os mesmos atletas foram submetidos a sessão de exercício agudo em três fases, com diferentes tratamentos: controle (C, dieta rica em AA (D e suplemento de AA (S, nas quais amostras de sangue foram colhidas antes, imediatamente após e 24 horas depois do exercício. Para comparação entre as fases e etapas foi utilizado o modelo de regressão linear com efeitos mistos. RESULTADOS: O consumo alimentar habitual de antioxidantes não foi diferente entre as fases, apenas a ingestão de AA foi maior na fase D e S em relação à fase C. O uso de dieta rica em AA favoreceu uma menor peroxidação lipídica, devido aos menores valores de hidroperóxidos lipídicos (FOX, diminuição da peroxidação após exercício, pela diminuição de substâncias reativas ao ácido tiobarbitúrico (TBARS e aumento dos níveis de vitamina C logo após o exercício. O uso de suplemento de AA também conteve a peroxidação lipídica após exercício e aumentou o poder antioxidante, devido aos maiores níveis de glutationa reduzida (GSH. Sem adição de AA os nadadores tiveram um maior dano hepático, pois apresentaram maiores níveis de transaminase-glutâmico-oxalacética (TGO, menores níveis de antioxidantes (vitamina C e GSH e aumento do ácido úrico. CONCLUSÃO: Assim, as mudanças observadas com a adição de AA à dieta de nadadores sugerem um importante papel deste micronutriente na defesa contra o estresse oxidativo induzido pelo exercício.

  10. Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K McVaugh Antocianinas, ácido ascórbico, polifenóis totais e atividade antioxidante na casca do camu-camu (Myrciaria dubia (H.B.K McVaugh

    Directory of Open Access Journals (Sweden)

    Juan Edson Villanueva-Tiburcio

    2010-05-01

    Full Text Available Este trabajo fue realizado en la UNAS, Tingo María, Perú. Los objetivos fueron evaluar el contenido de antocianinas, ácido ascórbico, y polifenoles totales, en la cáscara fresca y seca de camu-camu (Myrciaria dubia (H.B.K McVaugh en diferentes estados de madurez; evaluar la actividad antioxidante en la cáscara seca, usando diferentes tipos de radicales (DPPH, ABTS+ y Peroxilo y correlacionar el valor de ácido ascórbico y polifenoles totales con la actividad antioxidante. La extracción fue realizada en medio acuoso, y los resultados de las evaluaciones de cada experimento fueron analizados por un diseño completamente al azar (DCA, según la prueba de t-student (p A pesquisa foi realizada na UNAS em Tingo Maria, Peru, teve como objetivos: avaliar o teor de antocianinas, ácido ascórbico e polifenóis totais, na casca fresca e na casca seca do camu-camu (Myrciaria dubia (HBK McVaugh em diferentes tempos de maturação; avaliar a atividade antioxidante na casca seca utilizando diferentes tipos de radicais (DPPH, ABTS+ e Peroxilo e correlacionar o teor de ácido ascórbico e polifenóis totais com a atividade antioxidante. A extraç��o foi realizada em meio aquoso, os resultados das avaliações de cada experiência são analisados no delineamento inteiramente casualizado (DIC, pelo teste de t-student (p < 0,05. O extrato da casca da amostra madura fresca apresentou as concentrações mais elevadas de ácido ascórbico e de antocianinas em relação a meio madura e verde, com 21,95 mg.g-1 de casca e 46,42 mg.L-1 de cianidin-3-glucosídeo, respectivamente, enquanto que o extrato da casca seca meio madura apresentou o maior teor de ácido ascórbico em relação a madura e verde (53,49 mg.g-1 e de polifenóis totais: 7,70 mg Ác. Gálico/g. A maior atividade antioxidante foi encontrada no extrato da casca seca da amostra meio madura com IC50 = 46,20; 20,25 e 8,30 μg.mL-1, em comparação com DPPH radical, ABTS+ e Perox

  11. Research on: A. Reclamation of borrow pits and denuded lands; B. Biochemical aspects of mycorrhizae of forest trees

    Energy Technology Data Exchange (ETDEWEB)

    Marx, D.H. (comp.)

    1990-12-01

    This report furnishes a list of compiled and ongoing studies and a list of publications which resulted from the research accomplished by Institute scientists and other collaborators. The research accomplished can be placed in four categories: I. Research on borrow pit rehabilitation with 12 publications; II. Research on artificial regeneration of southern pines with 34 publications; III. Research on artificial regeneration of eastern hardwoods with 16 publications; and IV. Cooperative research with the University of Georgia on biochemical aspects of mycorrhizae with 5 publications. Major accomplishments of this research are: 1. Procedures to successfully reclaim borrow pits with sludge, subsoiling and seedlings with specific mycorrhizae. 2. Protocols to successfully artificially regenerate southern pines (particularly ling leaf pine) and certain eastern hardwoods. 3. Basic understanding of the biochemistry of mycorrhizae and the discovery of a new pathway for sucrose utilization in plants. 67 refs.

  12. The Financial Consequences of Too Many Men: Sex Ratio Effects on Saving, Borrowing, and Spending

    Science.gov (United States)

    Griskevicius, Vladas; Tybur, Joshua M.; Ackerman, Joshua M.; Delton, Andrew W.; Robertson, Theresa E.; White, Andrew E.

    2012-01-01

    The ratio of males to females in a population is an important factor in determining behavior in animals. We propose that sex ratio also has pervasive effects in humans, such as by influencing economic decisions. Using both historical data and experiments, we examined how sex ratio influences saving, borrowing, and spending in the United States. Findings show that male-biased sex ratios (an abundance of men) lead men to discount the future and desire immediate rewards. Male-biased sex ratios decreased men’s desire to save for the future and increased their willingness to incur debt for immediate expenditures. Sex ratio appears to influence behavior by increasing the intensity of same-sex competition for mates. Accordingly, a scarcity of women led people to expect men to spend more money during courtship, such as by paying more for engagement rings. These findings demonstrate experimentally that sex ratio influences human decision making in ways consistent with evolutionary biological theory. Implications for sex ratio effects across cultures are discussed. PMID:21767031

  13. The financial consequences of too many men: sex ratio effects on saving, borrowing, and spending.

    Science.gov (United States)

    Griskevicius, Vladas; Tybur, Joshua M; Ackerman, Joshua M; Delton, Andrew W; Robertson, Theresa E; White, Andrew E

    2012-01-01

    The ratio of males to females in a population is an important factor in determining behavior in animals. We propose that sex ratio also has pervasive effects in humans, such as by influencing economic decisions. Using both historical data and experiments, we examined how sex ratio influences saving, borrowing, and spending in the United States. Findings show that male-biased sex ratios (an abundance of men) lead men to discount the future and desire immediate rewards. Male-biased sex ratios decreased men's desire to save for the future and increased their willingness to incur debt for immediate expenditures. Sex ratio appears to influence behavior by increasing the intensity of same-sex competition for mates. Accordingly, a scarcity of women led people to expect men to spend more money during courtship, such as by paying more for engagement rings. These findings demonstrate experimentally that sex ratio influences human decision making in ways consistent with evolutionary biological theory. Implications for sex ratio effects across cultures are discussed.

  14. Fiscal determinants of government borrowing costs: do we have only ourselves to blame?

    Directory of Open Access Journals (Sweden)

    Josip Funda

    2013-06-01

    Full Text Available The global financial crisis and the problems in peripheral EU countries resulted in increased attention to fiscal developments and their impact on borrowing costs for both public and private sector. Existing theoretical literature suggests that worsening of current and expected budget balances as well as an increase of public debt lead to a rise in short and long term interest rates for sovereign debtors. However, empirical results are inconclusive, especially for emerging market countries. This paper analyzes the factors that determine the dynamics of government bond spreads, with special emphasis on fiscal indicators. The survey covered 17 European countries, of which 9 are developed and 8 are emerging market economies, all of them members of the EU except Croatia. The empirical part of the paper employs dynamic panel data method and uses the Arellano and Bond estimator to get consistent estimates of parameters of interest. The results show that in the period 2004-2011 fiscal balance and public debt projections had a significant impact on the differences in government bond yields for emerging market countries, with the effect being much stronger during the period after the onset of financial crises. On the other hand, it seems that sovereign spread dynamics in developed countries is driven mostly by the global market sentiment.

  15. The Impact of Central Bank Liquidity Infusions on Banks with High Level of Foreign Borrowing during the Crisis

    OpenAIRE

    Sokolov, V.

    2012-01-01

    Using data on foreign borrowing, I identify Russian banks that were affected by the sudden stop of external financing caused by the Lehman Brothers' collapse. Applying the difference-in-difference method, I compare these "affected" banks to "unaffected" ones and find that the Russian Central Bank's (CBR) anti-crisis financial assistance primarily went to the former group. Tracing the impact of the CBR's liquidity infusions on banks' portfolio allocation decisions, I find that banks used CBR f...

  16. hESC expansion and stemness are independent of connexin forty-three-mediated intercellular communication between hESCs and hASC feeder cells.

    Directory of Open Access Journals (Sweden)

    Jin-Su Kim

    Full Text Available BACKGROUND: Human embryonic stem cells (hESCs are a promising and powerful source of cells for applications in regenerative medicine, tissue engineering, cell-based therapies, and drug discovery. Many researchers have employed conventional culture techniques using feeder cells to expand hESCs in significant numbers, although feeder-free culture techniques have recently been developed. In regard to stem cell expansion, gap junctional intercellular communication (GJIC is thought to play an important role in hESC survival and differentiation. Indeed, it has been reported that hESC-hESC communication through connexin 43 (Cx43, one of the major gap junctional proteins is crucial for the maintenance of hESC stemness during expansion. However, the role of GJIC between hESCs and feeder cells is unclear and has not yet been reported. METHODOLOGY/PRINCIPAL FINDINGS: This study therefore examined whether a direct Cx43-mediated interaction between hESCs and human adipose-derived stem cells (hASCs influences the maintenance of hESC stemness. Over 10 passages, hESCs cultured on a layer of Cx43-downregulated hASC feeder cells showed normal morphology, proliferation (colony growth, and stemness, as assessed by alkaline phosphatase (AP, OCT4 (POU5F1-Human gene Nomenclature Database, SOX2, and NANOG expression. CONCLUSIONS/SIGNIFICANCE: These results demonstrate that Cx43-mediated GJIC between hESCs and hASC feeder cells is not an important factor for the conservation of hESC stemness and expansion.

  17. Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.

    Science.gov (United States)

    Gomes, Marco Tulio R; Campos, Priscila C; Oliveira, Fernanda S; Corsetti, Patricia P; Bortoluci, Karina R; Cunha, Larissa D; Zamboni, Dario S; Oliveira, Sergio C

    2013-04-01

    Pathogens are detected by innate immune receptors that, upon activation, orchestrate an appropriate immune response. Recent studies revealed the intracellular signaling cascades involved in the TLR-initiated immune response to Brucella abortus infection. However, no report has elucidated the role of inflammasome receptors in Brucella recognition. Therefore, we decided to investigate the function of NLRC4, NLRP3, and AIM2 in sensing Brucella. In this study, we showed that NLRC4 is not required to induce caspase-1 activation and further secretion of IL-1β by B. abortus in macrophages. In contrast, we determined that AIM2, which senses Brucella DNA, and NLRP3 are partially required for caspase-1 activation and IL-1β secretion. Additionally, mitochondrial reactive oxygen species induced by Brucella were implicated in IL-1β production. Furthermore, AIM2, NLRP3, ASC, and caspase-1 knockout mice were more susceptible to B. abortus infection than were wild-type animals, suggesting that multiple ASC-dependent inflammasomes contribute to host protection against infection. This protective effect is due to the inflammatory response caused by IL-1β and IL-18 rather than pyroptosis, because we observed augmented bacterial burden in IL-1R and IL-18 knockout mice. Finally, we determined that bacterial type IV secretion system VirB and live, but not heat-killed, Brucella are required for full inflammasome activation in macrophages during infection. Taken together, our results indicate that Brucella is sensed by ASC inflammasomes that collectively orchestrate a robust caspase-1 activation and proinflammatory response.

  18. Environmental assessment for the expansion and operation of the Central Shops Borrow Pit at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Department of Energy (DOE) prepared this Environmental Assessment (EA) to assess the potential environmental impacts of the proposed expansion and operation of an existing borrow pit at the Savannah River Site (SRS), located near Aiken, South Carolina. A borrow pit is defined as an excavated area where material has been dug for use as fill at another location. The proposed action would entail the areal enlargement, continued operation, and eventual close-out of the established facility known as the Central Shops Borrow Pit. Operations at SRS supporting waste site closure and the construction and maintenance of site facilities and infrastructure require readily available suitable soil for use as fill material. With the recent depletion of the other existing on-site sources for such material, DOE proposes to expand the existing facility. The National Environmental Policy Act requires the assessment of environmental consequences of Federal actions that may affect the quality of the human environment. Based on the potential for impacts described herein, DOE will either publish a Finding of No Significant Impact or prepare an Environmental Impact Statement (EIS).

  19. A Two-stage Damage Detection Method with Application to the Phase I ASCE SHM Benchmark Building%基于ASCE SHM Benchmark模型的两阶段结构损伤识别方法

    Institute of Scientific and Technical Information of China (English)

    刘朝; 雷鹰

    2011-01-01

    Recently,a new method has been proposed by the authors for detecting structural local damage under limited input and output measurements. This method can be extended to detect structural local damage in complex structures based on substructure approach. In this paper, based on this structural damage detection and localization method, a two-stage damage detection strategy is developed with application to the ASCE SHM benchmark building to test its efficacy and provide a systemic solution to the Phase Ⅰbenchmark problem far damage detection. In the first stage, an 8-DOF identification model is used to identify the floors and directions ( X or Y) in which damages are present. Then,the detection is focused on the floors where damage occurs. A substructure approach is utilized for damage localization in the second stage. A 12-DOF identification model is used for the substructure containing the damaged structural floors to identify the exact locations of damage. Structural parameters and the unknown inputs are identified by a recursive algorithm based on sequential application of the Kalman extended estimator for the extended state vector and the least squares estimation for the unknown inputs. Only a limited number of measured acceleration responses of the benchmark structure subject to unmeasured excitation inputs are utilized. Damage detection results indicate that the new method can detect and localize various damage patterns of the benchmark problems with good accuracy.%近年来,一种激励未知和输出部分已知条件下结构局部损伤识别的新方法得以提出,这种方法能基于子结构思想进行复杂结构的局部损伤识别,基于此方法,提出两阶段的损伤识别策略,并将其应用于第1阶段ASCESHM benchmark模型的case4的4种损伤识别,以检验此方法的有效性.在第1阶段,提出8-DOF的损伤模型以进行损伤层的定位;第2阶段,利用子结构的思想,提出12-DOF的损伤模型,在包含损伤层的

  20. The Problems of Application of the Social Role of Promotion and Borrowed Terminology in the Urban Trading Networks and the Media

    Directory of Open Access Journals (Sweden)

    Dalija Kemeklienė

    2011-04-01

    Full Text Available Nowadays advertising is of significant importance. Radio and television programmes, newspapers and magazines, various texts, even streets and shops are hardly imaginable without advertising. Advertising forms individuals’ as well as public attitude to many things in life. Besides it influences the person’s behavior and way of thinking. Advertising is inseparable part of the market; it helps create new working places, increases income and discloses positive qualities of manufactured products.However to create the correct, attractive and emotional body of the advert is not easy at all. Every person involved in advertising should be aware of that. In advertising texts vocabulary rules change, loanwords pushed, their standardisation and codification are noticed. In the period of integrating into the European Union, more new technological terms are used in the Lithuanian language. The language is being operated in virtual environment. New varieties of the language are being discovered - advertisement language and -communicative language. The problems of the usage of borrowed words also appear in the language.

  1. Should LSIL with ASC-H (LSIL-H in cervical smears be an independent category? A study on SurePath™ specimens with review of literature

    Directory of Open Access Journals (Sweden)

    Shidham Vinod

    2007-01-01

    Full Text Available Background: Cervical smears exhibiting unequivocal features of ′low grade squamous intraepithelial lesion′ (LSIL are occasionally also admixed with some cells suspicious for, but not diagnostic of, ′high grade squamous intraepithelial lesion′ (HSIL. Only a few studies, mostly reported as abstracts, have evaluated this concurrence. In this study, we evaluate the current evidence that favors a distinct category for "LSIL, cannot exclude HSIL" (LSIL-H, and suggest a management algorithm based on combinations of current ASCCP guidelines for related interpretations. Methods: We studied SurePath™ preparations of cervical specimens from various institutions during one year period. Cytohisto correlation was performed in cases with cervical biopsies submitted to our institution. The status of HPV DNA testing was also noted in some LSIL-H cases with biopsy results. Results: Out of 77,979 cases 1,970 interpreted as LSIL (1,523, LSIL-H (146, ′atypical squamous cells, cannot exclude HSIL′ (ASC-H (109, and HSIL (192 were selected. Concurrent biopsy results were available in 40% (Total 792 cases: 557 LSIL, 88 LSIL-H, 38 ASCH, and 109 HSIL. Biopsy results were grouped into A . negative for dysplasia (ND, B . low grade (HPV, CIN1, CIN1 with HPV, and C . high grade (CIN 2 and above. The positive predictive values for various biopsy results in relation to initial cytopathologic interpretation were: a . LSIL: (557 cases: ND 32% (179, low grade- 58% (323, high grade- 10% (55; b . LSIL-H: (88 cases: ND 24% (21, low grade- 43% (38, high grade- 33% (29; c . ASCH: (38 cases: ND 32% (12, low grade- 37% (14, high grade- 31% (12; d . HSIL (109 cases: ND 5% (6, low grade 26% (28, high grade 69% (75. The patterns of cervical biopsy results in cases reported as LSIL-H were compared with that observed in cases with LSIL, ASC-H, and HSIL. 94% (32 of 34 of LSIL-H were positive for high risk (HR HPV, 1 was negative for HR HPV but positive for low risk (LR, and 1 LSIL

  2. Hepatotoxicidad por exposición a plomo y su protección con tiamina y ácido ascórbico

    OpenAIRE

    Y. Alcaraz-Contreras; A. L. Pérez-Medina; A. G. Cárdenas-Pérez; M. A. Vázquez-Guevara; E. Durán-Castro; M. A. Deveze-Álvarez; M Martínez-Alfaro; X. S. Ramírez-Gómez

    2012-01-01

    En este trabajo se determinó el efecto hepatoprotector de tiamina y ácido ascórbico en ratas intoxicadas por plomo, en un esquema de dosis administradas como terapia individual y combinada. Los parámetros evaluados fueron: 1) marcadores de daño hepático (alanina aminotransferasa, aspartato aminotransferasa, fosfatasa alcalina) y 2) análisis histológico de cortes hepáticos. La administración de antioxidantes produjo disminución de los niveles de las enzimas evaluadas. A nivel histológico, se o...

  3. Contenido de osmoprotectores, ácido ascórbico y ascorbato peroxidasa en hojas de frijol sometidas a estrés por sequía

    OpenAIRE

    Teresa Susana Herrera Flores; Joaquín Ortíz Cereceres; Adriana Delgado Alvarado; Jorge Alberto Acosta Galleros

    2014-01-01

    La acumulación de osmoprotectores en plantas que se encuentran en condiciones de estrés por sequía, le permiten contrarrestar el efecto negativo que le provoca dichas condición ambiental. En el presente trabajo se estudió la respuesta bioquímica de plantas de frijol con base en la acumulación de carbohidratos solubles, almidón, ácido ascórbico, así como la actividad de la enzima ascorbato peroxidasa, en las hojas simples y en las dos primeras hojas trifolioladas de la variedad resistente, Pin...

  4. Impacto da estocagem sobre atividade antioxidante e teor de ácido ascórbico em sucos e refrescos de tangerina

    OpenAIRE

    Carolina Ferraz Figueiredo Moreira; Maria Lúcia Mendes Lopes; Vera Lúcia Valente-Mesquita

    2012-01-01

    OBJETIVO: Objetivou-se avaliar a estabilidade do ácido ascórbico em suco in natura de tangerina cultivar Ponkan sob diferentes condições de armazenamento, e em 13 amostras de bebidas industrializadas de tangerina, bem como a estabilidade da atividade antioxidante no suco in natura. MÉTODOS: O suco in natura de tangerina foi armazenado em três temperaturas: ambiente, refrigeração e congelamento. Amostras de tangerinas foram armazenadas sob refrigeração. Treze marcas de bebidas industrializadas...

  5. Propuesta de adaptación del documento ASCE/SEI31-03 “Evaluación Sísmica De Edificaciones Existentes”

    OpenAIRE

    López Palomino, Paulo Marcelo

    2014-01-01

    En este documento se presenta una propuesta de adaptación de la norma ASCE/SEI31-03 “Seismic Evaluation of Existing Buildings” de la American Society of Civil Engineers, para proporcionar una metodología de evaluación de edificaciones existentes en Colombia. Dicha metodología contiene el procedimiento de evaluación de edificaciones de diversos sistemas estructurales con materiales como: madera, mampostería, acero y concreto reforzado; también determina y analiza progresivamente y con compleji...

  6. Should LSIL with ASC-H (LSIL-H in cervical smears be an independent category? A study on SurePath™ specimens with review of literature

    Directory of Open Access Journals (Sweden)

    Shidham Vinod B

    2007-03-01

    Full Text Available Abstract Background Cervical smears exhibiting unequivocal features of 'low grade squamous intraepithelial lesion' (LSIL are occasionally also admixed with some cells suspicious for, but not diagnostic of, 'high grade squamous intraepithelial lesion' (HSIL. Only a few studies, mostly reported as abstracts, have evaluated this concurrence. In this study, we evaluate the current evidence that favors a distinct category for "LSIL, cannot exclude HSIL" (LSIL-H, and suggest a management algorithm based on combinations of current ASCCP guidelines for related interpretations. Methods We studied SurePath™ preparations of cervical specimens from various institutions during one year period. Cytohisto correlation was performed in cases with cervical biopsies submitted to our institution. The status of HPV DNA testing was also noted in some LSIL-H cases with biopsy results. Results Out of 77,979 cases 1,970 interpreted as LSIL (1,523, LSIL-H (146, 'atypical squamous cells, cannot exclude HSIL' (ASC-H (109, and HSIL (192 were selected. Concurrent biopsy results were available in 40% (Total 792 cases: 557 LSIL, 88 LSIL-H, 38 ASCH, and 109 HSIL. Biopsy results were grouped into A. negative for dysplasia (ND, B. low grade (HPV, CIN1, CIN1 with HPV, and C. high grade (CIN 2 and above. The positive predictive values for various biopsy results in relation to initial cytopathologic interpretation were: a. LSIL: (557 cases: ND 32% (179, low grade- 58% (323, high grade- 10% (55; b. LSIL-H: (88 cases: ND 24% (21, low grade- 43% (38, high grade- 33% (29; c. ASCH: (38 cases: ND 32% (12, low grade- 37% (14, high grade- 31% (12; d. HSIL (109 cases: ND 5% (6, low grade 26% (28, high grade 69% (75. The patterns of cervical biopsy results in cases reported as LSIL-H were compared with that observed in cases with LSIL, ASC-H, and HSIL. 94% (32 of 34 of LSIL-H were positive for high risk (HR HPV, 1 was negative for HR HPV but positive for low risk (LR, and 1 LSIL-H was

  7. Evaluación comparativa del ácido ascórbico y del tocoferol sobre la fertilidad de semen de gallo

    OpenAIRE

    Cumpa G., Marcial; Universidad Nacional Agraria La Molina (Perú).; Pomahuali, Joel; ,

    2016-01-01

    El presente trabajo de investigación se realizó en el Banco Nacional de Semen y la Unidad Experimental de Avicultura de la Universidad Nacional Agraria La Molina. Los objetivos de este estudio fueron evaluar comparativamente al ácido ascórbico y tocoferol sobre la fertilidad del semen refrigerado a 5°C de gallo. Se utilizaron 28 gallinas reproductoras de postura de 25 semanas de edad de las líneas Hy Line Brown y 6 gallos cruzados adultos de 30 meses de edad. Se establecieron 4 tratamientos d...

  8. Katakana variants yield better English pronunciation : Japanese-naive native American English speakers' perception of vowel length as stress in the recognition of Japanese borrowed English

    OpenAIRE

    Anthony, Mark

    2003-01-01

    An experiment was made to determine whether native American English speakers perceive vowel length in Japanese borrowed English words as stress. Native speakers of American English were asked to identify spoken tokens of words of both Japanese borrowed English and Japanese variants in which the vowel length had been altered. Significantly more variants were identified, establishing a perceptual link between Japanese vowel length and English stress, although identification of vowel-length vari...

  9. Toward a typology of health-related informal credit: an exploration of borrowing practices for paying for health care by the poor in Cambodia

    Directory of Open Access Journals (Sweden)

    Ir Por

    2012-11-01

    Full Text Available Abstract Background Borrowing money is a common strategy to cope with health care costs. The impact of borrowing on households can be severe, leading to indebtedness and further impoverishment. However, the available literature on borrowing practices for health is limited. We explore borrowing practices for paying for health care by the poor in Cambodia and provide a typology, associated conditions, and the extent of the phenomenon. Methods In addition to a semi-structured literature review, in-depth interviews were conducted with representatives of 47 households with health-related debt and 19 managers of formal or informal credit schemes. Results A large proportion of Cambodians, especially the poor, resort to borrowing to meet the cost of health care. Because of limited cash flow and access to formal creditors, the majority take out loans with high interest rates from informal money lenders. The most common type of informal credit is locally known as Changkar and consists of five kinds of loans: short-term loans, medium-term loans, seasonal loans, loans for an unspecified period, and loans with repayment in labour, each with different lending and repayment conditions and interest rates. Conclusion This study suggests the importance of informal credit for coping with the cost of treatment and its potentially negative impact on the livelihood of Cambodian people. We provide directions for further studies on financial protection interventions to mitigate harmful borrowing practices to pay for health care in Cambodia.

  10. HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian

    1999-03-30

    A vendor was selected for the diamond wire technology demonstration scheduled for this summer at Princeton Plasma Physics Laboratory (PPPL). A team consisting of personnel from FIU-HCET, PPPL, and AEA Technology reviewed the submitted bids. FIU-HCET will contract this vendor. At the SRS Ninth ICT teleconference, the ICT team discussed the status of the following demonstrations: LRAD; x-ray, K-edge; Strippable Coatings; Thermal Spray Vitrification; Cutting/Shearing/Dismantlement/Size Reduction; and Electrets. The LRAD demo is complete, and the x-ray/K-edge, Strippable Coatings, and Electrets demos are ongoing. The Asbestos and Thermal Spray Vitrification demos require more laboratory testing. The Cutting/Shearing/Dismantlement/Size Reduction demo is undergoing procurement. Five FIU-HCET staff members took the 1S0 14000 environmental auditor training course February 22-26, 1999, given by ASC. The test plan for the Facility Dismantlement Technology Assessment is finished and ready for internal review.

  11. Tracing lexical borrowings in the Balkans Albanian loan-words in the Serbian speech of Prizren

    Directory of Open Access Journals (Sweden)

    Petrović Snežana

    2003-01-01

    Full Text Available During the past centuries the city of Prizren has persisted as a unique multiethnic and multicultural environment atypical even for the Balkans, well-known for its ethnic, linguistic, cultural and religious diversity. Various nations used to live and pass through Prizren in the course of more than six centuries – the Serbs Turks, Albanians, Aromanians, Greeks and others – leaving their specific marks, visible on the city itself as well as the life and the mentality of its inhabitants. One of the most vivid testimonies to this long-term coexistence can be seen in vernaculars of the local population. This paper presents some Albanian loan-words from the Serbian speech of Prizren hitherto not registered (or not recognised as such in the respective etymological dictionaries and linguistic studies. The aim of this work is to offer their etymological analysis, through an investigation of the ways and mechanisms of lexical borrowing in the limited area of this town and to observe this phenomenon in a broader Balkan perspective. Analyzed are the following words: bajmak m., adj. indecl. "with bow legs (of man or horse", cub adj. indecl. "short; short-tailed", cub m., adj. indecl. "robber, outlaw", ćul adj. indecl. "soaking wet", điza f. "kind of crumbly cheese", glistra f. "worm", korse, korsem, krsem adv. "perhaps, as if", kulme n., kuljma f. "top of the roof", ljajka f. "lie", ljaper m. "idler", ljočka f. "darling, sweetheart", ljum adj. indecl. "dear", ljunga f. "boil; swelling", putarka f. "salted and dried caviar", ravš adv. "flat", roktar m. "servant, attendant", škret adj. "lonely, deserted, empty", škrum adj. indecl. "dry as ashes".

  12. Ácido ascórbico como agente redutor para determinação de fósforo por colorimetria

    Directory of Open Access Journals (Sweden)

    Lenio da Silva Santos

    2014-06-01

    Full Text Available Em muitos laboratórios de análises de solos, o ácido 1-Amino-2-naftol-4-sulfônico (ANS é usado como agente redutor para determinação do P por espectrometria de UV/Visível. Porém, devido aos riscos à saúde dos laboratoristas, uma alternativa é o uso do ácido ascórbico (AA. Entretanto, modificações no protocolo de análise podem induzir a variações nos resultados, havendo a necessidade de padronizá-las e calibrá-las. O objetivo do trabalho foi avaliar o ANS e AA nos extratos de Mehlich-1 e 3 nos intervalos de 15, 30, 45, 60 e 120min de reação. Não houve diferença na concentração de P determinado com ambos redutores quando comparados dentro de cada extrator. O ácido ascórbico pode substituir a solução ANS para determinação de P e o intervalo de tempo de reação sugerido para a quantificação colorimétrica é de 30 a 60min, para ambos redutores.

  13. Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells.

    Science.gov (United States)

    Naji, Abderrahim; Muzembo, Basilua André; Yagyu, Ken-Ichi; Baba, Nobuyasu; Deschaseaux, Frédéric; Sensebé, Luc; Suganuma, Narufumi

    2016-05-19

    The biological effects of indium-tin-oxide (ITO) are of considerable importance because workers exposed to indium compounds have been diagnosed with interstitial lung disease or pulmonary alveolar proteinosis; however, the pathophysiology of these diseases is undefined. Here, mice intraperitoneally inoculated with ITO-nanoparticles (ITO-NPs) resulted in peritonitis dependent in NLRP3 inflammasome, with neutrophils recruitment and interleukin-1β (IL-1β) production. Withal peritoneal macrophages exposed ex vivo to ITO-NPs caused IL-1β secretion and cytolysis. Further, alveolar macrophages exposed to ITO-NPs in vitro showed ITO-NP endocytosis and production of tumor necrosis factor-α (TNF-α) and IL-1β, ensued cell death by cytolysis. This cell death was RIPK1-independent but caspase1-dependent, and thus identified as pyroptosis. Endocytosis of ITO-NPs by activated THP-1 cells induced pyroptosis with IL-1β/TNF-α production and cytolysis, but not in activated THP-1 cells with knockdown of NLRP3, ASC, or caspase1. However, exposing activated THP-1 cells with NLRP3 or ASC knockdown to ITO-NPs resulted in cell death but without cytolysis, with deficiency in IL-1β/TNF-α, and revealing features of apoptosis. While, mesenchymal stem cells (MSCs) co-cultured with macrophages impaired both inflammation and cell death induced by ITO-NPs. Together, our findings provide crucial insights to the pathophysiology of respiratory diseases caused by ITO particles, and identify MSCs as a potent therapeutic.

  14. Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study

    Science.gov (United States)

    Pratta, Anne-Sophie; Abbassi, Nacira; Fabre, Hugo; Rodriguez, Fanny; Debard, Cyrille; Adobati, Jacqueline; Boucher, Fabien; Mallein-Gerin, Frédéric; Auxenfans, Céline; Damour, Odile; Mojallal, Ali

    2017-01-01

    Adipose-derived stem/stromal cells (ASCs) reside in the stromal vascular fraction (SVF) of adipose tissue (AT) and can be easily isolated. However, extraction of the SVF from lipoaspirate is a critical step in generating ASC, and semiautomated devices have been developed to enhance the efficacy and reproducibility of the outcomes and to decrease manipulation and contamination. In this study, we compared the reference method used in our lab for SVF isolation from lipoaspirate, with three medical devices: GID SVF-1™, Puregraft™, and Stem.pras®. Cell yield and their viability were evaluated as well as their phenotype with flow cytometry. Further on, we determined their proliferative potential using population doublings (PD), PD time (PDT), and clonogenicity assay (CFU-F). Finally, we checked their genetic stability using RT-qPCR for TERT mRNA assay and karyotyping as well as their multilineage potential including adipogenic, chondrogenic, and osteogenic differentiation. Our results demonstrate that all the devices allow the production of SVF cells with consistent yield and viability, in less time than the reference method. Expanded cells from the four methods showed no significant differences in terms of phenotype, proliferation capabilities, differentiation abilities, and genetic stability.

  15. Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Jonathan Rodriguez

    2017-01-01

    Full Text Available Adipose-derived stem/stromal cells (ASCs reside in the stromal vascular fraction (SVF of adipose tissue (AT and can be easily isolated. However, extraction of the SVF from lipoaspirate is a critical step in generating ASC, and semiautomated devices have been developed to enhance the efficacy and reproducibility of the outcomes and to decrease manipulation and contamination. In this study, we compared the reference method used in our lab for SVF isolation from lipoaspirate, with three medical devices: GID SVF-1™, Puregraft™, and Stem.pras®. Cell yield and their viability were evaluated as well as their phenotype with flow cytometry. Further on, we determined their proliferative potential using population doublings (PD, PD time (PDT, and clonogenicity assay (CFU-F. Finally, we checked their genetic stability using RT-qPCR for TERT mRNA assay and karyotyping as well as their multilineage potential including adipogenic, chondrogenic, and osteogenic differentiation. Our results demonstrate that all the devices allow the production of SVF cells with consistent yield and viability, in less time than the reference method. Expanded cells from the four methods showed no significant differences in terms of phenotype, proliferation capabilities, differentiation abilities, and genetic stability.

  16. ASC-J9(®) suppresses castration resistant prostate cancer progression via degrading the enzalutamide-induced androgen receptor mutant AR-F876L.

    Science.gov (United States)

    Wang, Ronghao; Lin, Wanying; Lin, Changyi; Li, Lei; Sun, Yin; Chang, Chawnshang

    2016-08-28

    Androgen deprivation therapy (ADT) with the newly developed powerful anti-androgen enzalutamide (Enz, also known as MDV3100) has promising therapeutic effects to suppress castration resistant prostate cancer (CRPC) and extending patients' lives an extra 4.8 months. However, most Enz therapy eventually fails with the development of Enz resistance. The detailed mechanisms how CRPC develops Enz resistance remain unclear and may involve multiple mechanisms. Among them, the induction of the androgen receptor (AR) mutant AR-F876L in some CRPC patients may represent one driving force that confers Enz resistance. Here, we demonstrate that the AR degradation enhancer, ASC-J9(®), not only degrades wild-type AR, but also has the ability to target AR-F876L. The consequence of suppressing AR-F876L may then abrogate AR-F876L mediated CRPC cell proliferation and metastasis. Thus, developing ASC-J9(®) as a new therapeutic approach may represent a novel therapy to better suppress CRPC that has already developed Enz resistance.

  17. The APTIMA HPV assay versus the Hybrid Capture 2 test in triage of women with ASC-US or LSIL cervical cytology: a meta-analysis of the diagnostic accuracy.

    Science.gov (United States)

    Arbyn, Marc; Roelens, Jolien; Cuschieri, Kate; Cuzick, Jack; Szarewski, Ann; Ratnam, Sam; Reuschenbach, Miriam; Belinson, Suzanne; Belinson, Jerome L; Monsonego, Joseph

    2013-01-01

    Testing for DNA of 13 high-risk HPV types with the Hybrid Capture 2 (HC2) test has consistently been shown to perform better in triage of women with cervical cytology results showing atypical squamous cells of undetermined significance (ASC-US) but often not in triage of low-grade squamous intraepithelial lesions (LSIL) detected in cervical cancer screening. In a meta-analysis, we compared the accuracy of the APTIMA HPV test, which identifies RNA of 14 high-risk HPV types, to HC2 for the triage of women with ASC-US or LSIL. Literature search-targeted studies where the accuracy of APTIMA HPV and HC2 for detection of underlying CIN2/3+ was assessed concomitantly including verification of all cases of ASC-US and LSIL. HSROC (Hierarchical Summary ROC) curve regression was used to compute the pooled absolute and relative sensitivity and specificity. Eight studies, comprising 1,839 ASC-US and 1,887 LSIL cases, were retrieved. The pooled sensitivity and specificity of APTIMA to triage ASC-US to detect underlying CIN3 or worse was 96.2% (95% CI = 91.7-98.3%) and 54.9% (95% CI = 43.5-65.9%), respectively. APTIMA and HC2 showed similar pooled sensitivity; however, the specificity of the former was significantly higher (ratio: 1.19; 95% CI = 1.08-1.31 for CIN2+). The pooled sensitivity and specificity of APTIMA to triage LSIL were 96.7% (95% CI = 91.4-98.9%) and 38.7% (95% CI = 30.5-47.6%) for CIN3+. APTIMA was as sensitive as HC2 but more specific (ratio: 1.35; 95% CI = 1.11-1.66). Results were similar for detection of CIN2 or worse. In both triage of ASC-US and LSIL, APTIMA is as sensitive but more specific than HC2 for detecting cervical precancer.

  18. Decrease-radix design principle for carrying/borrowing free multi-valued and application in ternary optical computer

    Institute of Scientific and Technical Information of China (English)

    YAN JunYong; JIN Yi; ZUO KaiZhong

    2008-01-01

    In this paper a new theory referred to as the decrease-radix design (DRD) is proposed,which is found in the research of logic units of ternary (tri-valued) optical computer.Based on the theory proposed,the principles and the regulations of the DRD for making operation units of multi-valued operation with carrying/borrowing free are also presented.The research work has come to the following important conclusion:let D be a special state contained in n physical informative states,then one may figure out any multi-valued processors within n(n×n) carrying/borrowing free n-valued units by the composition some of n×n×(n-1) simplest basic operating units according to the regulations of DRD proposed in this paper.The detailed systematic way of our design regulations is highlighted step by step in the paper with an example of design of a tri-valued logic optical operating unit.The real architecture,the procedure,and the experimental results of our sample in tri-valued logic operating unit are given.Finally,a re-constructible model of ternary logical optical processor is introduced.The theory proposed in the paper has laid down a solid foundation for the design of re-constructible carrying/borrowing free operating units in ternary optical computers and can be widely used as the designing reference in a variety of multi-valued logic operating units.

  19. IFRS COMPLIANCE REGARDING INFORMATION DISCLOSED BY COMPANIES IN CONSOLIDATED FINANCIAL STATEMENTS - CASE STUDY ON IAS 23 BORROWING COSTS APPLICABILITY-

    Directory of Open Access Journals (Sweden)

    Dragu Ioana - Maria

    2011-07-01

    Full Text Available This paper concentrates on information disclosure regarding IAS 23, being included in accounting research field. It comprises an empirical study on the correlation between information published by companies in consolidated financial statements with respect to borrowing cost policies and a series of variables that characterize a firm. The objectives of this paper involve estimating and establishing an econometric model in which is assumed that disclosure index for information required by IAS 23 depends on certain elements in the form of country of origin, sales, total assets, debt ratio, ROA and ROE. International accounting literature presents a series of studies on the subject of compliance with IAS disclosure requirements. Similar with this paper, various authors considered annual reports as starting point for data gathering in their reasearch on disclosure phenomena. The criteria used for data gathering, processing and analysing have been previously used in a successful manner by important scientists who published in accounting field. The methodology used involves Disclosure Index computation, as well as SPSS data processing, analysis and interpretation of results. Results show that the model is valid, meaning that there is correlation between information disclosure with respect to IAS 23 and the analyzed variables. According to our estimated econometric model, most of the variables maintain a certain influence on disclosure as we can observe a significant correlation level between the studied elements. This research contributes to the development of both accounting field and international accounting literature, by studying borrowing costs disclosed information in relation to certain elements that best characterize the activity of a company. Although an empirical paper, it concentrates also on accounting practices, as it uses real data extracted from annual reports and consolidated financial statements. The importance of this research relies

  20. Restricción alimentaria en pollo de engorda para la prevención del síndrome ascítico y su efecto en el ingreso neto

    OpenAIRE

    Israel Salinas; Eliseo Sosa; Arturo Pro; Carlos M. Becerril; Juan M. Cuca; Roberto García

    2004-01-01

    Se realizaron dos experimentos con pollos de engorda para evaluar el efecto de la restricción alimentaria (RA) en la prevención del síndrome ascítico y en el ingreso neto. Se determinó la ganancia de peso corporal (GP), consumo de alimento (CA), eficiencia alimentaria (EA), mortalidad total y por síndrome ascítico (MSA). En el Experimento 2 se evaluó el rendimiento de la canal y el porcentaje de grasa abdominal. El diseño experimental fue completamente al azar con mediciones repetidas de siet...

  1. THE EFFECTS OF 2008 GLOBAL ECONOMIC CRISIS ON BORROWING RATES OF MANUFACTURING COMPANIES: PRE-CRISIS AND CRISIS COMPARISON

    OpenAIRE

    Dömbekci, Berna

    2014-01-01

    The global economic crisis of 2008 has affected more or less every country. Governments have to take special precautions to ease the severe effects of the crisis in their financial and real sectors. The interest rate is an important indicator of economic stability and should be maintained at a level where the economic agents do not decide to postpone their growth plans. For this reason, this article will focus on the effects of the 2008 global economic crisis on the borrowing rates of Turkish...

  2. Related Variety, Unrelated Variety and Technological Breakthroughs: An analysis of US State-Level Patenting

    NARCIS (Netherlands)

    Castaldi, C.; Frenken, K.; Los, B.

    2015-01-01

    Castaldi C., Frenken K. and Los B. Related variety, unrelated variety and technological breakthroughs: an analysis of US state-level patenting, Regional Studies. This paper investigates how variety affects the innovation output of a region. Borrowing arguments from theories of recombinant innovation

  3. 新准则借款费用资本化会计处理的思考%Some Issues About Capitalization of Borrowing Costs Under New Standards

    Institute of Scientific and Technical Information of China (English)

    叶丹

    2012-01-01

    The Enterprise Accounting Standards,which was issued in February 2006,completed the borrowing costs and formulated the Enterprise Accounting Standards No. 17 - Borrowing Costs,which had a greater impact on corporate accounting. This article,based on the relevant provisions under the new borrowing cost standards,simply analyzed the changes between the old and new standards and the problems in the implementation process of new borrowing cost standards,and then came up with some suggestions on how to improve the borrowing costs guidelines.%财政部颁布的《企业会计准则》对借款费用部分进行了修整,制定了《企业会计准则第17号——借款费用》,这对企业的会计核算产生了较大影响。文章立足新《借款费用准则》中的相关规定,简单分析了新旧准则的变化,对新《借款费用准则》在执行过程中所存在的问题进行的分析,进而就如何完善《借款费用准则》提出了相应的建议。

  4. The factors of the lack of reimbursement of the microfinance institutions: Empirical evidence in the case of the Tunisian micro- borrowers

    Directory of Open Access Journals (Sweden)

    Mighri Zohair

    2013-05-01

    Full Text Available This research studies the relevance of explanatory factors of the lack of reimbursement in microfinance conceived on the side of the socio-economic and demographic characteristics of the micro-borrowers. In fact, these factors have generally been little discussed in the literature. This research, falls under this objective to explore the context of the microfinance as regards lack of reimbursement and to find solutions to minimize this risk of insolvency. In other words, the issue is connected to the identification of the influence of the characteristics specific to the micro-borrowers on the probability so that an individual carries out a lack of reimbursement.To study the determinants of the reimbursement rate of the micro-borrowers, this paper is divided into three principal parts. First of all, on the basis of the theoretical framework, we will focus ourselves particularly, on the explanatory factors of the lack of reimbursement in microfinance which are related to the particular characteristics of the micro-borrowers, and we will try also to formulate the fundamental assumptions of our research. Then, we will discuss our sample and our results of estimates in order to treat our fundamental question of research. At this level, we will try to empirically analyze the validity of the assumptions by the presentation and the analysis of the principal results, in order to identify the explanatory factors of the lack of reimbursement on the side of the micro-borrowers.

  5. DoD Electronic Data Interchange (EDI) Convention. ASC X12 Transaction Set 858 Personal Property Shipment Information (Version 003010)

    Science.gov (United States)

    1993-04-01

    technology , data must be transferred between a user database and an EDI translator. The first step to designing that data transfer, or "interface," is...nil Eusdemene loop start L0*500 n/I Etitleamuit mb-loop Mart Ll 0000480O000**40000 n/i Moble homme and emsm codt paid SE*4200001 nil Transaction. set

  6. Do ideal ascético ao ideal estético: a evolução histórica da Anorexia Nervosa

    Directory of Open Access Journals (Sweden)

    Cybelle Weinberg

    2010-06-01

    Full Text Available O estudo da anorexia nervosa sob uma perspectiva histórica visa contribuir para a investigação daquilo que se configura como influência cultural na gênese e manutenção do quadro, além de questionar posições segundo as quais a anorexia nervosa seria um "mal da modernidade" ou decorrente de um único fator. Uma análise da vida das santas da Idade Média, por exemplo, mostra quanto o comportamento perseverante as aproxima das anoréxicas de hoje, ainda que a motivação e os ideais (ascético nas primeiras e estético nas últimas sejam diferentes.

  7. Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.

    Science.gov (United States)

    Wu, Qiong; Liu, Ming-Chao; Yang, Jun; Wang, Jiu-Feng; Zhu, Yao-Hong

    2015-12-11

    Escherichia coli is a major environmental pathogen causing bovine mastitis, which leads to mammary tissue damage and cell death. We explored the effects of the probiotic Lactobacillus rhamnosus GR-1 on ameliorating E. coli-induced inflammation and cell damage in primary bovine mammary epithelial cells (BMECs). Increased Toll-like receptor 4 (TLR4), NOD1, and NOD2 mRNA expression was observed following E. coli challenge, but this increase was attenuated by L. rhamnosus GR-1 pretreatment. Immunofluorescence and Western blot analyses revealed that L. rhamnosus GR-1 pretreatment decreased the E. coli-induced increases in the expression of the NOD-like receptor family member pyrin domain-containing protein 3 (NLRP3) and the serine protease caspase 1. However, expression of the adaptor protein apoptosis-associated speck-like protein (ASC, encoded by the Pycard gene) was decreased during E. coli infection, even with L. rhamnosus GR-1 pretreatment. Pretreatment with L. rhamnosus GR-1 counteracted the E. coli-induced increases in interleukin-1β (IL-1β), -6, -8, and -18 and tumor necrosis factor alpha mRNA expression but upregulated IL-10 mRNA expression. Our data indicate that L. rhamnosus GR-1 reduces the adhesion of E. coli to BMECs, subsequently ameliorating E. coli-induced disruption of cellular morphology and ultrastructure and limiting detrimental inflammatory responses, partly via promoting TLR2 and NOD1 synergism and attenuating ASC-independent NLRP3 inflammasome activation. Although the residual pathogenic activity of L. rhamnosus, the dosage regimen, and the means of probiotic supplementation in cattle remain undefined, our data enhance our understanding of the mechanism of action of this candidate probiotic, allowing for development of specific probiotic-based therapies and strategies for preventing pathogenic infection of the bovine mammary gland. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  8. Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC adipocytes.

    Directory of Open Access Journals (Sweden)

    Darwin V Lee

    Full Text Available Fibroblast growth factor 21 (FGF21 has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by which FGF21 exerts its metabolic effects, we developed a human in vitro model of adipocytes to examine crosstalk between FGF21 and insulin signaling. Human adipose stem cell-derived (hASC adipocytes were acutely treated with FGF21 alone, insulin alone, or in combination. Insulin signaling under these conditions was assessed by measuring tyrosine phosphorylation of insulin receptor (InsR, insulin receptor substrate-1 (IRS-1, and serine 473 phosphorylation of Akt, followed by a functional assay using 14C-2-deoxyglucose [14C]-2DG to measure glucose uptake in these cells. FGF21 alone caused a modest increase of glucose uptake, but treatment with FGF21 in combination with insulin had a synergistic effect on glucose uptake in these cells. The presence of FGF21 also effectively lowered the insulin concentration required to achieve the same level of glucose uptake compared to the absence of FGF21 by 10-fold. This acute effect of FGF21 on insulin signaling was not due to IR, IGF-1R, or IRS-1 activation. Moreover, we observed a substantial increase in basal S473-Akt phosphorylation by FGF21 alone, in contrast to the minimal shift in basal glucose uptake. Taken together, our data demonstrate that acute co-treatment of hASC-adipocytes with FGF21 and insulin can result in a synergistic improvement in glucose uptake. These effects were shown to occur at or downstream of Akt, or separate from the canonical insulin signaling pathway.

  9. TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection.

    Directory of Open Access Journals (Sweden)

    Jesus Segovia

    Full Text Available Human respiratory syncytial virus (RSV constitute highly pathogenic virus that cause severe respiratory diseases in newborn, children, elderly and immuno-compromised individuals. Airway inflammation is a critical regulator of disease outcome in RSV infected hosts. Although "controlled" inflammation is required for virus clearance, aberrant and exaggerated inflammation during RSV infection results in development of inflammatory diseases like pneumonia and bronchiolitis. Interleukin-1β (IL-1β plays an important role in inflammation by orchestrating the pro-inflammatory response. IL-1β is synthesized as an immature pro-IL-1β form. It is cleaved by activated caspase-1 to yield mature IL-1β that is secreted extracellularly. Activation of caspase-1 is mediated by a multi-protein complex known as the inflammasome. Although RSV infection results in IL-1β release, the mechanism is unknown. Here in, we have characterized the mechanism of IL-1β secretion following RSV infection. Our study revealed that NLRP3/ASC inflammasome activation is crucial for IL-1β production during RSV infection. Further studies illustrated that prior to inflammasome formation; the "first signal" constitutes activation of toll-like receptor-2 (TLR2/MyD88/NF-κB pathway. TLR2/MyD88/NF-κB signaling is required for pro-IL-1β and NLRP3 gene expression during RSV infection. Following expression of these genes, two "second signals" are essential for triggering inflammasome activation. Intracellular reactive oxygen species (ROS and potassium (K(+ efflux due to stimulation of ATP-sensitive ion channel promote inflammasome activation following RSV infection. Thus, our studies have underscored the requirement of TLR2/MyD88/NF-κB pathway (first signal and ROS/potassium efflux (second signal for NLRP3/ASC inflammasome formation, leading to caspase-1 activation and subsequent IL-1β release during RSV infection.

  10. Borrower Decision Support Model for Online Lending%网络借贷借款人决策辅助模型

    Institute of Scientific and Technical Information of China (English)

    陈冬宇; 李伟军; 丁婕

    2012-01-01

    In order to assist an effective decision for the online lending borrower, we apply Logistic regression in to calculate the probability for the securing a loan. Based on the Logistic regression of the data from PPdai. com, we build new kinds of tools for decision makers to help the borrower to quantify her strategic options to get loans. In the training set of the prediction model, the comprehensive prediction rate reached 89.6% and the comprehensive prediction rate in validation set is 85.8%. Such result indicates that our model is valid.%为了辅助网络借贷借款人进行有效决策,将逻辑回归算法应用于网络借贷成功满标率的研究.在对PPdai平台的借贷数据进行Logistic回归的基础上,构建了一个决策辅助工具,通过在不同借贷指标下对借贷成功满标的预测,帮助借款人选择自己的借贷标准,以便更成功地获得贷款.实验结果表明,该预测模型训练集综合预测率达到89.6%,验证集综合预测率为85.8%,说明该模型是有效的.

  11. 英汉习语翻译中的框架借用%Frame Borrowing in English Idioms Translation

    Institute of Scientific and Technical Information of China (English)

    张小奎

    2012-01-01

    认知框架是基于文化约定俗成的知识构型,连接多个认知域的知识网络并与某个特定的语言形式相关联,从而建立概念与概念之间相对应的模式。习语是语言的核心与精华,具有强烈的文化特点;这种文化差异反映在认知层面,则表现为框架的巨大差异。在习语翻译中,如果能够将源语文化中的框架构型成功的转换到目的语中,就为跨文化交际和翻译打下坚实的基础。框架借用视角下英汉习语翻译的策略主要包括"直接借用源语的框架结构,保留源语的喻体形象","借用目的语相似的框架,寻求相应的喻体形象","借用译入语里有着相似喻义的不同框架"和"‘零’框架借用"。对框架借用的应用研究有助于提高英汉习语的翻译实践水平。%Cognitive frames are culturally - conventionalized configurations. They combine the knowledge networks of mul- tiple cognitive domains within a certain language and establish a correlation model between concepts and concepts. Idioms are the core of a certain language that is culturally characterized. The great cultural differences are reflected as the huge frame differences by and large from the viewpoint of cognitive linguistics. It would lay a solid foundation for the better understanding of cultural communication and translation, should the frame configurations in the source language be trans- formed maximally into the target language in the courses of idiom translation. Judging from the viewpoint of frame borrowing, the strategies for idiom translation include "borrow the original frame into the target language, keeping the original images in the source language", "borrow a similar frame from the target language, seeking for the equivalent images in the target language", "borrow a different frame from the target language that shares the common image connotation"and "zero borrowing". The study on frame borrowing is greatly

  12. Effectiveness of two strategies to follow-up ASC-US and LSIL screening results in The Netherlands using repeat cytology with or without additional hrHPV testing: a retrospective cohort study

    NARCIS (Netherlands)

    Siebers, A.G.; Arbyn, M.; Melchers, W.J.; Kemenade, F.J. van; Vedder, J.E.; Linden, H. van der; Ballegooijen, M. van; Bekkers, R.L.; Bulten, J.

    2014-01-01

    PURPOSE: The purpose of the study was to assess the effectiveness of repeat cytology with and without additional high-risk human papilloma virus (hrHPV) testing after atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion (ASC-US/LSIL) screening results.

  13. Factores asociados a displasia, en mujeres con diagnóstico citológico de atipias de células escamosas de significado indeterminado (ASC-US

    Directory of Open Access Journals (Sweden)

    Jorge Luis Monroy Díaz

    2011-01-01

    Full Text Available Objetivo: Identificar los factores asociados a displasia en mujeres que asisten al Hospital Central de la Policía Nacional o diferentes dispensarios cuya citología cervicovaginal presentaba, atipias de células escamosas de significado indeterminado (ASC-US.

  14. Primary study on the isolation,culture and identification of rat ASCs%大鼠脂肪干细胞的分离培养及鉴定的初步研究

    Institute of Scientific and Technical Information of China (English)

    雷蕙嘉; 孙建军; 彭本刚; 张宁; 朱思翔

    2011-01-01

    目的 探讨大鼠脂肪干细胞(adipose-derived stem cells,ASCs)分离、培养及纯化方法,并对其表面标志进行鉴定.方法 以Wistar大鼠为研究对象,取其腹股沟皮下脂肪组织,经冲洗、剪碎成浆状后,以Ⅱ型胶原酶消化.消化液经滤网过滤后,离心悬浮细胞,并接种于培养瓶内.经差速贴壁法纯化细胞.以免疫荧光方法对其表面标志CD44,CD29及CD106,CD34进行鉴定.激光共聚焦显微镜下观察评估.结果 原代培养的ASCs呈星型或多角型,经传代后的ASCs形态比较均一,呈长梭形,漩涡样生长.冻存复苏后的ASCs仍保持较好的活力,存活率较高.经差速贴壁法可获得较纯的ASCs.免疫荧光检测ASCs表面标志鉴定结果显示CD44,CD29阳性表达,CD106,CD34阴性表达.结论 本研究进一步改进的了ASCs分离培养及纯化方法,为ASCs最终应用于临床提供了有意义的实验依据.%Objective  To investigate the isolation ,cell culture and purification of adipose-derived stem cells (ASCs) from rats and to identify their surfacse markers .Methods  Wister rats were selected and adipose tissues were obtained from the inguinalregion .The tissues were washed extensively ,minced into small pieces and digested with collagenase type Ⅱ .The digested mixture was then passed through a cell strainer and was centrifuged .The pellet of ASCs was then suspended and seeded in a plastic cellculture bottle .The cells were purified by the method of differential speed of adherence .The cell surface markers of CD 44 ,CD 29 ,CD 106 and CD 34 were identified by immuno fluore scence and analyzed by a confocal laser scan microscopy system .Results  The primary cultured ASCs grew into large and stellate-shaped cells .A fter severalpassage ,confluent ASCs showed a spindle-shaped ,fibroblast-like morphology and grew as a whirlpool .ASC maintained better viability and displayed the higher survivalrate after cryopreservation .Relatively pure ASCs were

  15. Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+ using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US in Catalonia, Spain

    Directory of Open Access Journals (Sweden)

    Ibáñez Raquel

    2012-01-01

    Full Text Available Abstract Background A protocol for cervical cancer screening among sexually active women 25 to 65 years of age was introduced in 2006 in Catalonia, Spain to increase coverage and to recommend a 3-year-interval between screening cytology. In addition, Human Papillomavirus (HPV was offered as a triage test for women with a diagnosis of atypical squamous cells of undetermined significance (ASC-US. HPV testing was recommended within 3 months of ASC-US diagnosis. According to protocol, HPV negative women were referred to regular screening including a cytological exam every 3 years while HPV positive women were referred to colposcopy and closer follow-up. We evaluated the implementation of the protocol and the prediction of HPV testing as a triage tool for cervical intraepithelial lesions grade two or worse (CIN2+ in women with a cytological diagnosis of ASC-US. Methods During 2007-08 a total of 611 women from five reference laboratories in Catalonia with a novel diagnosis of ASC-US were referred for high risk HPV (hrHPV triage using high risk Hybrid Capture version 2. Using routine record linkage data, women were followed for 3 years to evaluate hrHPV testing efficacy for predicting CIN2+ cases. Logistic regression analysis was used to estimate the odds ratio for CIN2 +. Results Among the 611 women diagnosed with ASC-US, 493 (80.7% had at least one follow-up visit during the study period. hrHPV was detected in 48.3% of the women at study entry (mean age 35.2 years. hrHPV positivity decreased with increasing age from 72.6% among women younger than 25 years to 31.6% in women older than 54 years (p At the end of the 3 years follow-up period, 37 women with a diagnosis of CIN2+ (18 CIN2, 16 CIN3, 2 cancers, and 1 with high squamous intraepithelial lesions -HSIL were identified and all but one had a hrHPV positive test at study entry. Sensitivity to detect CIN2+ of hrHPV was 97.2% (95%confidence interval (CI = 85.5-99.9 and specificity was 68.3% (95%CI

  16. An Overview of English Loanwords from Perspective of Their Borrowing Process, Formation and Sources%An Overview of English Loanwords from Perspective of Their Borrowing Process,Formation and Sources

    Institute of Scientific and Technical Information of China (English)

    孙韬

    2016-01-01

    As an integrated imported part and orthography adapted from the receiving language, loanwords in English are derived from a donor language and a recipient language by specific methods. This essay is a tentative study of the structural features of English loanwords with an aim to help English learners have a better understanding of their formation, different categories and changes of English loanwords. What's more, the translation of loanwords and internal formalization are also taken into consideration for the purpose of interpreting how they are formed and what they mean as well. By analyzing the structural features of English vocabulary, the transliteration and main sources of borrowing are interpreted to remind the English learners to have a rational attitude towards the loanwords.

  17. High-resolution global grids of revised Priestley–Taylor and Hargreaves–Samani coefficients for assessing ASCE-standardized reference crop evapotranspiration and solar radiation

    Directory of Open Access Journals (Sweden)

    V. G. Aschonitis

    2017-08-01

    Full Text Available The objective of the study is to provide global grids (0.5° of revised annual coefficients for the Priestley–Taylor (P-T and Hargreaves–Samani (H-S evapotranspiration methods after calibration based on the ASCE (American Society of Civil Engineers-standardized Penman–Monteith method (the ASCE method includes two reference crops: short-clipped grass and tall alfalfa. The analysis also includes the development of a global grid of revised annual coefficients for solar radiation (Rs estimations using the respective Rs formula of H-S. The analysis was based on global gridded climatic data of the period 1950–2000. The method for deriving annual coefficients of the P-T and H-S methods was based on partial weighted averages (PWAs of their mean monthly values. This method estimates the annual values considering the amplitude of the parameter under investigation (ETo and Rs giving more weight to the monthly coefficients of the months with higher ETo values (or Rs values for the case of the H-S radiation formula. The method also eliminates the effect of unreasonably high or low monthly coefficients that may occur during periods where ETo and Rs fall below a specific threshold. The new coefficients were validated based on data from 140 stations located in various climatic zones of the USA and Australia with expanded observations up to 2016. The validation procedure for ETo estimations of the short reference crop showed that the P-T and H-S methods with the new revised coefficients outperformed the standard methods reducing the estimated root mean square error (RMSE in ETo values by 40 and 25 %, respectively. The estimations of Rs using the H-S formula with revised coefficients reduced the RMSE by 28 % in comparison to the standard H-S formula. Finally, a raster database was built consisting of (a global maps for the mean monthly ETo values estimated by ASCE-standardized method for both reference crops, (b global maps for the revised annual

  18. Proceedings of the Conference on Graduate Student Research in Engineering and Technology Education (Minneapolis, Minnesota, May 22, 2008)

    Science.gov (United States)

    National Center for Engineering and Technology Education, 2008

    2008-01-01

    As part of the usual end of year meeting that has been a feature of the National Center for Engineering and Technology Education (NCETE) project, a conference intending to provide a forum for young voices in an outside of the Center was organized. The basic model for the gathering was borrowed from track and field. This was to be an intellectual…

  19. Government borrowing and the long-term interest rate: Application of an extended loanable funds model to the Slovak Republic

    Directory of Open Access Journals (Sweden)

    Hsing Yu

    2010-01-01

    Full Text Available Extending the open-economy loanable funds model, this paper finds that more government borrowing as a percent of GDP leads to a higher government bond yield, that a higher real money market rate, a higher expected inflation rate, a higher EU government bond yield, or a decrease in the Slovak nominal effective exchange rate would increase the Slovak government bond yield, and that the positive coefficient of the percent change in real GDP is insignificant at the 10% level. When the standard closedeconomy or open-economy loanable funds model is considered, except that the positive coefficient of the ratio of the net capital inflow to GDP is insignificant at the 10% level, other results are similar.

  20. Loss-Averse Inventory and Borrowing Decisions with Constraints on Working Capital in Fashion and Textiles Industry

    Directory of Open Access Journals (Sweden)

    Lijun Ma

    2013-01-01

    Full Text Available Traditional inventory models focus on operational decisions and inventory control. Quite few models consider the financial constraint and decision bias such as loss aversion, which are the reality in today's business environment, especially for the fashion and textiles industry. In this paper we study the inventory control problem for a loss-averse retailer with financial constraint for operations in a periodic review setting in a finite horizon. We characterize the optimal inventory control policies with self-financing or with borrowing as capital-dependent base-stock policies. We demonstrate with numerical examples that the optimal base-stock level is nonincreasing in the accumulated wealth and the loss-aversion indicator.

  1. Slovene Normative Guides and Borrowing of Greek-Latin Elements: From Tradition to Prestige and towards the User

    Directory of Open Access Journals (Sweden)

    Helena Dobrovoljc

    2016-12-01

    Full Text Available In the normative Slovene tradition, the borrowing of proper names from the Latin and Greek world was treated as exclusionist and often accompanied by contradictory instructions for common language users, who belonged to various levels of social differentiation. By contrast, the fund of common nouns underwent a relatively quick phonetic adaptation. An exception is the individual expressions which are treated in our language community as prestigious, i.e. intellectual, and are thus preserved as direct quotations. It is due to the aforementioned factors in codifying the Latin-Greek lexicon and names that the contemporary standard language norm lacks uniformity. The article presents the existing principles of Slovenisation illustrated by a selected group of words, and the experiences which await us in the future.

  2. 7 CFR 1950.104 - Borrower owing FmHA or its successor agency under Public Law 103-354 loans which are secured by...

    Science.gov (United States)

    2010-01-01

    ... Public Law 103-354 loans which are secured by real estate. 1950.104 Section 1950.104 Agriculture... owing FmHA or its successor agency under Public Law 103-354 loans which are secured by real estate... borrowers with FmHA or its successor agency under Public Law 103-354 loans secured by real estate who...

  3. Educational Borrowing as Negotiation: Re-Examining the Influence of the American Black Industrial Education Model on British Colonial Education in Africa

    Science.gov (United States)

    Yamada, Shoko

    2008-01-01

    This study explores the extent to which American educational ideas made an impact on policy-making and practice of education in British African colonies between the two World Wars. The analysis re-examines the apparent "borrowing" of American black industrial education models for application in Africa. It is argued that, while the view…

  4. Educational Borrowing as Negotiation: Re-Examining the Influence of the American Black Industrial Education Model on British Colonial Education in Africa

    Science.gov (United States)

    Yamada, Shoko

    2008-01-01

    This study explores the extent to which American educational ideas made an impact on policy-making and practice of education in British African colonies between the two World Wars. The analysis re-examines the apparent "borrowing" of American black industrial education models for application in Africa. It is argued that, while the view that…

  5. Direct Student Loans: Additional Steps Would Increase Borrowers' Awareness of Electronic Debiting and Reduce Federal Administrative Costs. Report to the Honorable James M. Jeffords, U.S. Senate.

    Science.gov (United States)

    Ashby, Cornelia M.

    In November 1999, the U.S. Department of Education began offering a 0.25% interest rate reduction to borrowers under the Direct Loan program who agree to have their monthly loan payments automatically withdrawn from a bank account through its electronic debit account (EDA) program. The Department of Education submitted a justification to the…

  6. Sediment Transport and Infilling of a Borrow Pit on an Energetic Sandy Ebb Tidal Delta Offshore of Hilton Head Island, South Carolina

    Science.gov (United States)

    Wren, A.; Xu, K.; Ma, Y.; Sanger, D.; Van Dolah, R.

    2014-12-01

    Bottom-mounted instrumentation was deployed at two sites on an ebb tidal delta to measure hydrodynamics, sediment transport, and seabed elevation. One site ('borrow site') was 2 km offshore and used as a dredging site for beach nourishment of nearby Hilton Head Island in South Carolina, and the other site ('reference site') was 10 km offshore and not directly impacted by the dredging. In-situ time-series data were collected during two periods after the dredging: March 15 - June 12, 2012('spring') and August 18 - November 18, 2012 ('fall'). At the reference site directional wave spectra and upper water column current velocities were measured, as well as high-resolution current velocity profiles and suspended sediment concentration profiles in the Bottom Boundary Layer (BBL). Seabed elevation and small-scale seabed changes were also measured. At the borrow site seabed elevation and near-bed wave and current velocities were collected using an Acoustic Doppler Velocimeter. Throughout both deployments bottom wave orbital velocities ranged from 0 - 110 m/s at the reference site. Wave orbital velocities were much lower at the borrow site ranging from 10-20 cm/s, as wave energy was dissipated on the extensive and rough sand banks before reaching the borrow site. Suspended sediment concentrations increased throughout the BBL when orbital velocities increased to approximately 20 cm/s. Sediment grain size and critical shear stresses were similar at both sites, therefore, re-suspension due to waves was less frequent at the borrow site. However, sediment concentrations were highly correlated with the tidal cycle at both sites. Semidiurnal tidal currents were similar at the two sites, typically ranging from 0 - 50 cm/s in the BBL. Maximum currents exceeded the critical shear stress and measured suspended sediment concentrations increased during the first hours of the tidal cycle when the tide switched to flood tide. Results indicate waves contributed more to sediment mobility at

  7. Does the ThinPrep Imaging System increase the detection of high-risk HPV-positive ASC-US and AGUS? The Women and Infants Hospital experience with over 200,000 cervical cytology cases

    Directory of Open Access Journals (Sweden)

    Quddus M

    2009-01-01

    Full Text Available Background: Published reports have demonstrated that introduction of the ThinPrep Imaging System (Imager to the cytology screening services has increased the detection rate of high-grade squamous intraepithelial lesions (HSILs. In accordance with recent clinical treatment guidelines, patients with atypical squamous or glandular cells of undetermined significance (ASC-US or AGUS are often tested for high-risk HPV infection using the Hybrid Capture HPV DNA test. We took the opportunity to investigate whether the Imager had resulted in any significant differences in our diagnostic categories, as well as whether the Imager increased the detection of high-risk HPV-DNA-positive (HRHPV+ ASC-US or AGUS. Materials and Methods: Cytology cases with the diagnosis of ASC-US and AGUS were retrieved from the archival files of our institution during periods of 11 months prior to and 11 months after the introduction of the Imager. The total number of cases in each category was correlated with results of reflex high-risk HPV DNA testing when the latter were available. All AGUS diagnoses were correlated with subsequent biopsy follow-up. Statistical analyses were performed using the chi-Square test with Yate′s Correction and Fisher′s Exact test. Results: A total of 108,371 and 104,555 of ThinPrep ® Pap Test (TPPT cases were reviewed during 11 months pre- and post-imager introduction. The ASC-US rate was 5.4% in the pre-Imager and 5.3% in the post-Imager period. The HPV reflex test was 38% and 34% positive respectively in the pre- and post-Imager period ( P >0.124. Similarly, 0.14% and 0.12% AGUS were found in the pre- and post-Imager period. The positive HPV reflex test was 14% versus 23% ( P = 0.1690. The abnormal biopsy follow-up rate in the AGUS category was increased from 20.9% in the pre-Imager period to 31% in the post-Imager period ( P = 0.1471. The ASCUS/SIL ratios were 1.9 and 1.6 respectively. Conclusions: The ASC-US and AGUS rates did not change

  8. What language shall I borrow? The poetry of Rainer Maria Rilke and the care of souls.

    Science.gov (United States)

    Jones, Logan C

    2004-01-01

    This article suggests that the reality of the world is socially constructed through the words and narratives chosen and used. These social constructions may be from science and technology, business and economics, or poetry and metaphors, and as such each shapes a different world. The work of the poet Rainer Maria Rilke is used to illustrate how the power of words and images shape and form the world. The implications of the use of language for the care of souls are discussed.

  9. ATP Induces IL-1β Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis

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    Killen García

    2016-01-01

    Full Text Available Neisseria gonorrhoeae (Ngo has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1β secretion of infected human monocyte-derived macrophages (MDM. Here, we investigate the role of adenosine triphosphate (ATP in production and release of IL-1β in Ngo-infected MDM. We found that the exposure of Ngo-infected MDM to ATP increases IL-1β levels about ten times compared with unexposed Ngo-infected MDM (P0.05 and caspase-1 (CASP1, P>0.05. In addition, ATP was not able to modify caspase-1 activity in Ngo-infected MDM but was able to increase pyroptosis (P>0.01. Notably ATP treatment defined an increase of positive staining for IL-1β with a distinctive intracellular pattern of distribution. Collectively, these data demonstrate that ATP induces IL-1β secretion by a mechanism not related to the NLRP3/ASC/caspase-1 axis and likely is acting at the level of vesicle trafficking or pore formation.

  10. ATP Induces IL-1β Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis

    Science.gov (United States)

    García, Killen; Escobar, Gisselle; Mendoza, Pablo; Beltran, Caroll; Perez, Claudio; Vernal, Rolando; Acuña-Castillo, Claudio

    2016-01-01

    Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1β secretion of infected human monocyte-derived macrophages (MDM). Here, we investigate the role of adenosine triphosphate (ATP) in production and release of IL-1β in Ngo-infected MDM. We found that the exposure of Ngo-infected MDM to ATP increases IL-1β levels about ten times compared with unexposed Ngo-infected MDM (P 0.05) and caspase-1 (CASP1, P > 0.05). In addition, ATP was not able to modify caspase-1 activity in Ngo-infected MDM but was able to increase pyroptosis (P > 0.01). Notably ATP treatment defined an increase of positive staining for IL-1β with a distinctive intracellular pattern of distribution. Collectively, these data demonstrate that ATP induces IL-1β secretion by a mechanism not related to the NLRP3/ASC/caspase-1 axis and likely is acting at the level of vesicle trafficking or pore formation. PMID:27803513

  11. Restricción alimenticia y salbutamol en el control del síndrome ascítico en pollos de engorda: 1. comportamiento productivo y características de la canal

    OpenAIRE

    González, Juan M.; Maria Elena Suárez; Arturo Pro; Carlos López

    2000-01-01

    El síndrome ascítico es una de las causas de mayor mortalidad en pollos de engorda, afectando también sus características productivas. Se estableció un experimento para medir el efecto combinado de restricción alimenticia (0 ó 25 % menos del consumo normal) y salbutamol (0 ó 2 mg kg-1) en la incidencia del síndrome ascítico, comportamiento productivo y características de la canal de pollos de engorda. La restricción alimenticia fue del día 7 al 21 de edad y el salbutamol se adicionó al alimen...

  12. Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs: An experimental and in silico study

    Directory of Open Access Journals (Sweden)

    Abdorrahim Absalan

    2017-03-01

    Full Text Available Objective(s: To investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. In addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (TIPs using in silico studies. Materials and Methods: Human adipose derived stem cells (hASCs were studied under treatments with 2.5 µM/ml cinnamaldehyde, 0.1 µg/ml eugenol, 0.01% DMSO or any additive. The expression of TERT, AKT1 and DKC1 genes and the telomere length were assessed over 48-hr treatment. In addition, docking study was conducted to show probable ways through which phytochemicals interact with TIPs. Results: Treated and untreated hASCs had undetectable TERT expression, but they did affect the AKT1 and DKC1 expression levels (CI=0.95; P

  13. Quantificação de compostos fenólicos e ácido ascórbico em frutos e polpas congeladas de acerola, caju, goiaba e morango

    Directory of Open Access Journals (Sweden)

    Juliana Mesquita Freire

    2013-12-01

    Full Text Available O crescente interesse da população pela promoção da saúde vem despertando a atenção dos consumidores por alimentos ricos em antioxidantes, combinado com a praticidade do consumo de sucos de frutos processados. O presente trabalho objetivou quantificar e avaliar a capacidade antioxidante de compostos fenólicos e ácido ascórbico em frutas in natura e polpas congeladas. As frutas in natura e polpas congeladas obtidas na região de Lavras - MG foram submetidas à quantificação de compostos fenólicos e ácido ascórbico e os respectivos extratos acetônico-etanólico e acetônico-metanólico. Foram determinadas suas atividades antioxidantes pelos métodos radicalares DPPH e ABTS. O extrato acetônico-metanólico foi mais efetivo para extrair os compostos antioxidantes das amostras. Apenas as polpas congeladas de acerola apresentaram uma redução do teor de compostos fenólicos em relação ao fruto. Para o teor de ácido ascórbico, houve uma redução nas polpas congeladas de acerola e goiaba. As amostras de acerola apresentaram os maiores teores de compostos fenólicos, ácido ascórbico e atividade antioxidante em relação aos demais frutos analisados.

  14. Clinical performance of hybrid capture 2 human papillomavirus testing for recurrent high-grade cervical/vaginal intraepithelial neoplasm in patients with an ASC-US Papanicolaou test result during long-term posttherapy follow-up monitoring.

    Science.gov (United States)

    De Vivar, Andrea Diaz; Dawlett, Marilyn; Wang, Jian-Ping; Jack, Annie; Gong, Yun; Staerkel, Gregg; Guo, Ming

    2015-02-01

    Women who have been treated for high-grade cervical or vaginal intraepithelial neoplasia (CIN or VAIN) or invasive carcinoma are at risk for recurrent/persistent disease and require long-term monitoring. The role of human papillomavirus (HPV) testing in this setting is unclear. To evaluate the clinical performance of the Hybrid Capture 2 (HC2) HPV test for recurrent/residual high-grade CIN or VAIN in patients with a posttherapy abnormal squamous cells of undetermined significance (ASC-US) Papanicolaou test result. We reviewed the follow-up data on 100 patients who had an ASC-US Papanicolaou test and HC2 HPV results after treatment for high-grade CIN/VAIN or carcinoma. Human papillomavirus genotyping was performed for women with a negative HC2 result whose follow-up biopsy revealed CIN/VAIN 2+. The patients' mean age was 47 years. The HC2 test result was positive in 33% of the patients. Follow-up biopsy was available for 17 of these patients (52%) and for 25 of the 67 patients (37%) with a negative HC2 result. A total of 5 of the patients (29%) with a positive HC2 result and 2 of the patients (8%) with a negative HC2 result had CIN/VAIN 3 on follow-up biopsy, a statistically insignificant difference (P = .10). Human papillomavirus 16/18 genotypes were detected in the CIN/VAIN 2+ lesions of 5 patients with a negative HC2 result. HC2 yielded a false-negative rate of 8% for CIN 3. HC2 testing therefore may not be sufficient for triage of patients with an ASC-US Papanicolaou test result. Patients with ASC-US during long-term posttherapy follow-up need close monitoring, with colposcopic evaluation if clinically indicated.

  15. A survey of the wetlands and floodplains of the borrow area and wetland/shorebird complex for the remedial action at the chemical plant area of the Weldon Spring Site

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.; Yin, S.; Hlohowskyj, I.

    1995-02-01

    The US Department of Energy is conducting cleanup operations at the Weldon Spring site, St. Charles, Missouri, that will include development of a 77-ha (191-acre) soil borrow area. Eight wetlands, including riverine and palustrine emergent wetland types and totaling 0.9 ha (2.2 acres), will be eliminated during excavation of the borrow area. A 23-ha (57-acre) wetland/shorebird complex will be created at the Busch Conservation Area. The complex will include 2 ha (5 acres) of palustrine emergent wetland as mitigation for wetland losses in the borrow area.

  16. Ascite neoplásica: efeito da solução aquosa de fenol, ácido acético e glicerina sobre o tumor ascítico de Ehrlich

    Directory of Open Access Journals (Sweden)

    Saad-Hossne Rogério

    2003-01-01

    Full Text Available OBJETIVO: Verificar o efeito da solução composta por fenol, ácido acético e glicerina sobre o tumor ascítico de Ehrlich. MÉTODOS: Utilizou-se 283 camundongos divididos em 2 protocolos (animais portadores e não portadores de tumor procedendo-se a injeção de 0,25 ml, 0,10 ml e 0,05 ml da solução teste e 0,25 ml de solução salina, o sacrifício foi realizado após 3 e 6 dias do tratamento, analisando, a seguir, a contagem diferencial de células presentes no líquido ascítico. RESULTADOS: Observou-se que nos animais portadores de tumor houve uma redução significante do número de células tumorais e aumento do número de células inflamatórias, nos animais sem tumor observou-se influxo de células inflamatórias para a cavidade peritoneal. CONCLUSÃO: A solução proposta causa, in vivo, a diminuição do número de células tumorais e aumento do número de células inflamatórias no líquido ascítico.

  17. Polyurethane/Polylactide-Blend Films Doped with Zinc Ions for the Growth and Expansion of Human Olfactory Ensheathing Cells (OECs and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs for Regenerative Medicine Applications

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-04-01

    Full Text Available Polymeric biomaterials based on polyurethane and polylactide blends are promising candidates for regenerative medicine applications as biocompatible, bioresorbable carriers. In current research we showed that 80/20 polyurethane/polylactide blends (PU/PLDL with confirmed biological properties in vitro may be further improved by the addition of ZnO nanoparticles for the delivery of bioactive zinc oxide for cells. The PU/PLDL blends were doped with different concentrations of ZnO (0.001%, 0.01%, 0.05% and undertaken for in vitro biological evaluation using human adipose stromal stem cells (ASCs and olfactory ensheathing cells (OECs. The addition of 0.001% of ZnO to the biomaterials positively influenced the morphology, proliferation, and phenotype of cells cultured on the scaffolds. Moreover, the analysis of oxidative stress markers revealed that 0.001% of ZnO added to the material decreased the stress level in both cell lines. In addition, the levels of neural-specific genes were upregulated in OECs when cultured on sample 0.001 ZnO, while the apoptosis-related genes were downregulated in OECs and ASCs in the same group. Therefore, we showed that PU/PLDL blends doped with 0.001% of ZnO exert beneficial influence on ASCs and OECs in vitro and they may be considered for future applications in the field of regenerative medicine.

  18. The Effect of Age on Osteogenic and Adipogenic Differentiation Potential of Human Adipose Derived Stromal Stem Cells (hASCs and the Impact of Stress Factors in the Course of the Differentiation Process

    Directory of Open Access Journals (Sweden)

    Katarzyna Kornicka

    2015-01-01

    Full Text Available Human adipose tissue is a great source of autologous mesenchymal stem cells (hASCs, which are recognized for their vast therapeutic applications. Their ability to self-renew and differentiate into several lineages makes them a promising tool for cell-based therapies in different types of degenerative diseases. Thus it is crucial to evaluate age-related changes in hASCs, as the elderly are a group that will benefit most from their considerable potential. In this study we investigated the effect of donor age on growth kinetics, cellular senescence marker levels, and osteogenic and adipogenic potential of hASCs. It also has been known that, during life, organisms accumulate oxidative damage that negatively affects cell metabolism. Taking this into consideration, we evaluated the levels of nitric oxide, reactive oxygen species, and superoxide dismutase activity. We observed that ROS and NO increase with aging, while SOD activity is significantly reduced. Moreover cells obtained from older patients displayed senescence associated features, for example, β-galactosidase activity, enlarged morphology, and p53 protein upregulation. All of those characteristics seem to contribute to decreased proliferation potential of those cells. Our results suggest that due to aging some cellular modification may be required before applying aged cells efficiently in therapies such as tissue engineering and regenerative medicine.

  19. Suscetibilidade de linhagens de frangos de corte à síndrome ascítica Ascites syndrome effects in different commercial broilers

    Directory of Open Access Journals (Sweden)

    Manoel Garcia Neto

    2004-08-01

    Full Text Available O objetivo deste trabalho foi estudar a suscetibilidade à síndrome ascítica de machos e fêmeas em linhagens comerciais de frango de corte. Todas as aves receberam ração ad libitum com 3.050 kcal/ME. Foram comparadas as linhagens comerciais representadas pela Cobb, Hubbard e Ross, machos e fêmeas. O delineamento utilizado foi o inteiramente casualizado, em esquema fatorial. As aves foram aleatoriamente alojadas em um galpão experimental de 8x76 m, com 18 boxes de 3x3,5 m cada e 100 aves por divisão, num total de 1.800 aves. Os resultados revelaram que a incidência de ascite independe da linhagem comercial dos frangos de corte, entretanto, os machos foram mais suscetíveis.The objective of this work was to verify the incidence of ascites in males and females on commercial lines of broilers. All birds received ration ad libitum with 3,050 kcal/ME. The commercial lines Cobb, Hubbard and Ross, males and females, were compared. A factorial design was used with three replications per treatment. A total of 1,800 birds were housed at random in an experimental shed of 8x76 m, with 18 compartments of 3x3.5 m each and 100 birds per division. The results showed that the incidence of ascites was independent of the commercial broiler line, however, males were more susceptible.

  20. QUANTITATIVE MEASUREMENT OF THE SIMILARITIES AND DIFFERENCES OF CLONES OF GRAPES USING CONTOURS OF LEAVES WITH THE USE OF ASC-ANALYSIS AND "EIDOS" SYSTEM

    Directory of Open Access Journals (Sweden)

    Lutsenko Y. V.

    2016-02-01

    Full Text Available The article discusses the application of automated system-cognitive analysis (ASC-analysis, its mathematical model is a system of information theory and implements, its software tools – intellectual system called "Eidos" for solving one of the important tasks of ampelography: to quantify the similarities and differences of different clones of grapes using contours of the leaves. To solve this task we perform the following steps: 1 digitization of scanned images of the leaves and creation their mathematical models; 2 formation mathematical models of specific leaves with the application of information theory; 3 modeling the generalized images of leaves of different clones on the basis of specific leaves (multiparameter typing; 4 verification of the model by identifying specific leaf images with generic clones, i.e., classes (system identification; 5 quantification of the similarities and differences of the clones, i.e. cluster-constructive analysis of generalized images of leaves of various clones. The specific shape of the contour of the leaf is regarded as noise information on the clone to which it relates, including information about the true shape of a leaf of this clone (clean signal and noise, which distort the real shape, due to the random influence of the environment. Software tools of ASA-analysis which is intellectual "Eidos" system provides the noise suppression and the detection of a signal about the true shape of a leaf of each clone on the basis of a number of noisy concrete examples of the leaves of this clone. This creates a single image of the shape of the leaf of each clone, independent of their specific implementations, i.e. "Eidos" of these images (in the sense of Plato - the prototype or archetype (in the Jungian sense of the images

  1. 探讨英语中的外来语%The Analysis of Loan Words or Borrowing Words in English

    Institute of Scientific and Technical Information of China (English)

    谢利君

    2010-01-01

    A well-known fact about English is that it shows an impression of vividness and similarity, which is not only because America itself is composed of many major nations, but because it has borrowed a great many words from other languages in the process of its formation and development. Loan words reflect the different cultural connection, enrich English vocabulary and show the contents of new things more accurately, visually and directly, thus it makes English more internationalized.%英语词汇总是给人一种生动和似曾相识的印象.一方面的原因是美国是由世界各主要民族组成的,另一个原因是英语在其形成和发展过程中大量借用了其他民族的语言.外来语反映了不同的文化联系,丰富了英语词汇,更加准确、形象和直观地反映新事物的内容,使英语更加国际化.了解英语外来语的发展过程、成因和来源地,有利于加强对英语的理解.

  2. Analysis of sediment, water, and biological samples from the Bay Farm Borrow Area, San Francisco Bay, California

    Energy Technology Data Exchange (ETDEWEB)

    Thom, R.M.; Lefkovitz, L.F. (Battelle/Marine Sciences Lab., Sequim, WA (United States))

    1991-08-01

    The Bay Farm Borrow Area (BFBA) of San Francisco Bay, California, is under consideration as a dredged-material disposal site by the US Army Corps of Engineers (USACE). As part of the analysis of the site, information is required on the quality of benthic biota, sediment, and water in the BFBA. The objective of this report was to provide data on infauna communities, sediment, and water chemistry from samples collected from the BFBA. The samples were collected, and the data will be analyzed by Science Applications International (SAIC). A total of four samples for sediment chemistry, four samples for water chemistry, and 7 samples for infauna communities were analyzed by the Battelle/Marine Sciences Laboratory (MSL). Water analyses included tests for dissolved organic carbon, total suspended solids, four metals, butyltins, polychlorinated biphenyls (PCBs), chlorinated pesticides, polynuclear aromatic hydrocarbons (PAHs), four phenols, and total phenol. Sediment samples were analyzed for percent solids, total organic carbon, total oil and grease, total petroleum hydrocarbons, grain size, 10 metals, butyltins, PCBs, chlorinated pesticides, PAHs, four phenols, and total phenol. The data along with controls and spike recovery analyses, are presented in tables, and the results are discussed in the text. The quality assurance/quality control criteria were met for the analyses as were the detection limits specified by the sponsor.

  3. The English Borrowings and the Indonesian-English Codeswitching in Two Collections of Blog Short-Stories

    Directory of Open Access Journals (Sweden)

    Anna Marietta da Silva

    2013-01-01

    Full Text Available If one has ever read fiction works by prominent Indonesian authors from 1920‟s Abdul Muis, and Marah Rusli, 1930‟s Sutan Takdir Alisjahbana and Armijn Pane, 1945‟s Chairil Anwar and Achdiat K. Mihardja, 1950-1960‟s Pramoedya Ananta Toer, W. S. Rendra, and N. H. Dini, 1960-1970‟s Taufik Ismail, Goenawan Moehammad, and Sapardi Djoko Darmono, and compared their work with those of the 1990‟s Hilman Sriwijaya and Ayu Utami, and the 2000‟s Hirata, one must have found many differences among the works. More obvious distinction will be discovered if all of the works previously mentioned are contrasted with those of 2000‟s teen writers like Arunita, Mentari, Andries, and recently Dika, especially in terms of style and vocabulary. The most recent teen fictions have employed much colloquial Indonesian or Malay-Betawi dialect (Djenar, 2008, and English lexical items. This study shows that in Dika‟s blog short-stories alone, English borrowings and Indonesian-English code-switching were commonly found. English seems to be the third language after the colloquial and standard Indonesian with which the author thinks

  4. Resource sharing in libraries concepts, products, technologies, and trends

    CERN Document Server

    Breeding, Marshall

    2014-01-01

    Supplementing your local collection through resource sharing is a smart way to ensure your library has the resources to satisfy the needs of your users. Marshall Breeding's new Library Technology Report explores technologies and strategies for sharing resources, helping you streamline workflows and improve resource-sharing services by covering key strategies like interlibrary loan, consortial borrowing, document delivery, and shared collections. You'll also learn about such trends and services as:OCLC WorldCat Resource Sharing, and other systems that facilitate cooperative, reciprocal lendingS

  5. 试论外来语对英语的影响%A Tentative Study of the influence of the borrowing words on English

    Institute of Scientific and Technical Information of China (English)

    邓雨露

    2014-01-01

    As we all know, English, the internationalized language, has been widely used all around the world. It is its great inclusiveness and flexibility that make it become a vigorous language with a lot of words borrowed from other countries. The borrowings not only enrich the vocabulary of English, make the English expression more vivid and adequate, but also have great in-fluence on the usage of English. This thesis takes borrowing as the subject and starts with the main causing factor, the category, focusing on the changes on the vocabulary, grammar and pronunciation of English.%众所周知,英语,作为一门国际化的语言,在世界各国被广泛使用。它的宽容和灵活性,使它大量吸收外来词汇,从而具有了顽强的生命力。外来词汇极大地丰富了英语,使英语表达起来更加生动和贴切,并且对英语的使用方法也产生了很大影响。本文从外来语的成因,分类开始,将重点介绍英语外来语对英语词汇,语法和语音产生的影响。

  6. 炼油企业借用商业储备原油探讨%An Examination of the Borrowing Crude Oil by Oil of Commercial Refineries

    Institute of Scientific and Technical Information of China (English)

    施雷

    2012-01-01

    As one of the operation modes of commercial reserves of crude oil, the borrowing of commercial reserves of crude oil can help refineries to mitigate the shortage of crude oil supply, ease financial burden, save finance costs and reduce the costs of crude oil procurement. tion should be paid to making right decisions menting effective precautions against risks. In practice, when borrowing commercial reserves of crude oil, atten- on borrowing and returning times, applying price tools and imple-%借用商业储备原油作为商业储备原油的运作模式之一,有利于炼油企业解决原油供应紧张、减轻资金压力、节省财务费用、降低原油采购成本。在具体运作上,借用商业储备原油要注意把握借还时机、利用价格工具、有效防控风险。

  7. Development of a Prototype Model to Establish an Economic Earthwork Plan that Includes the Selection of a Dump Site/Borrow Pit

    Directory of Open Access Journals (Sweden)

    Seung Hak Lee

    2017-01-01

    Full Text Available Earthwork in road construction projects is the major activity that accounts for about 20%–30% of the total construction cost, and the internal/external hauling plan is the key factor for determining the successful completion of the project. However, the hauling plan at the site, which includes the selection of the dump site and borrow pit, is usually determined by the site manager’s subjective and empirical discretion alone. Therefore, this study has developed a prototype model that provides the optimal internal/external hauling plan. It includes the determination of the most economical dump sites and borrow pits (location and number among other candidate sites as well. The transshipment problem theory is incorporated into the optimized algorithm with the consideration of various factors affecting earthwork cost. Direct costs from an optimized transport based on an existing model against another from this model were compared to prove its feasibility. As a result, the reduction of earthwork cost including the dump site/borrow pits reached 4%–8%. This result implies that this prototype model would also be useful in reducing both the earthwork cost and the occurrence of exhaust gas from earthwork equipment by providing optimized transportation paths.

  8. 约束国债借款的理论机制分析——基于当前借款约束模型的研究趋势追踪%Analysis on Mechanism of Government Borrowing Constraint --A Research Based on Present-value Borrowing Constraint Model

    Institute of Scientific and Technical Information of China (English)

    何代欣

    2011-01-01

    Oversized scale of government debt is a financial problem troubling various countries. Are there theoretical mechanisms of government borrowing constraint to guide the debt scale and resolve the debt risk? This study finds that government borrowing constraint contains at least three key factors: fiscal imbalance can be effectively measured; creditors' expectations need to be taken into account; government debt must be converged. Micro-expectation and stock of wealth are the basis for government debt borrowing, and debt convergence and relevant economic variable effect are the major causes of debt scale's change. It's concluded that the borrowing constraint mechanism based on present-value borrowing constraint model is a powerful measure for the sustainability of government debt scale.%国债规模过大是一直困扰各国政府的财政难题。是否存在国债借款约束的理论机制,用以指导债务规模,化解债务风险?研究发现,国债借款约束至少包含三个关键方面:财政收支不平衡可以有效测量、债权方的预期有必要予以考虑、国债规膜必须收敛。微观预期和财富状况是国债借款的基础,而债务收敛和相关经济变量作用是债务规模变化的主要诱因。结论认为,以当前借款约束模型为基础的国债借款约束机制是衡量国债规模可持续性的有力工具。

  9. Advanced Stirling Technology Development at NASA Glenn Research Center

    Science.gov (United States)

    Shaltens, Richard K.; Wong, Wayne A.

    2007-01-01

    The NASA Glenn Research Center has been developing advanced energy-conversion technologies for use with both radioisotope power systems and fission surface power systems for many decades. Under NASA's Science Mission Directorate, Planetary Science Theme, Technology Program, Glenn is developing the next generation of advanced Stirling convertors (ASCs) for use in the Department of Energy/Lockheed Martin Advanced Stirling Radioisotope Generator (ASRG). The next-generation power-conversion technologies require high efficiency and high specific power (watts electric per kilogram) to meet future mission requirements to use less of the Department of Energy's plutonium-fueled general-purpose heat source modules and reduce system mass. Important goals include long-life (greater than 14-yr) reliability and scalability so that these systems can be considered for a variety of future applications and missions including outer-planet missions and continual operation on the surface of Mars. This paper provides an update of the history and status of the ASC being developed for Glenn by Sunpower Inc. of Athens, Ohio.

  10. INTELLIGENT MANAGEMENT OF THE QUALITY OF SYSTEMS BY SOLVING A GENERALIZED ASSIGNMENT PROBLEM WITH THE USE OF ASC-ANALYSIS AND "EIDOS-X++" SYSTEM

    Directory of Open Access Journals (Sweden)

    Lutsenko Y. V.

    2015-05-01

    decision-making process for selections, i.e. 2nd task, has been implemented in the ASC-analysis and in the system called "Eidos" X++". The article also provides a simplified numerical example of the proposed approach with the selection of staff members

  11. A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

    Directory of Open Access Journals (Sweden)

    Ying Zheng

    2011-04-01

    Full Text Available A type III secretion system (T3SS in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent cell death and caspase-1 activation occur in Yersinia-infected macrophages. One pathway of cell death and caspase-1 activation in macrophages requires the effector YopJ. YopJ is an acetyltransferase that inactivates MAPK kinases and IKKβ to cause TLR4-dependent apoptosis in naïve macrophages. A YopJ isoform in Y. pestis KIM (YopJ(KIM has two amino acid substitutions, F177L and K206E, not present in YopJ proteins of Y. pseudotuberculosis and Y. pestis CO92. As compared to other YopJ isoforms, YopJ(KIM causes increased apoptosis, caspase-1 activation, and secretion of IL-1β in Yersinia-infected macrophages. The molecular basis for increased apoptosis and activation of caspase-1 by YopJ(KIM in Yersinia-infected macrophages was studied. Site directed mutagenesis showed that the F177L and K206E substitutions in YopJ(KIM were important for enhanced apoptosis, caspase-1 activation, and IL-1β secretion. As compared to YopJ(CO92, YopJ(KIM displayed an enhanced capacity to inhibit phosphorylation of IκB-α in macrophages and to bind IKKβ in vitro. YopJ(KIM also showed a moderately increased ability to inhibit phosphorylation of MAPKs. Increased caspase-1 cleavage and IL-1β secretion occurred in IKKβ-deficient macrophages infected with Y. pestis expressing YopJ(CO92, confirming that the NF-κB pathway can negatively regulate inflammasome activation. K+ efflux, NLRP3 and ASC were important for secretion of IL-1β in response to Y. pestis KIM infection as shown using macrophages lacking inflammasome components or by the addition of exogenous KCl. These data show that caspase-1 is activated in naïve macrophages in response to infection with a pathogen that inhibits IKKβ and MAPK kinases and induces TLR4-dependent apoptosis. This pro

  12. THE APPLICATION OF ASC-ANALYSIS TO DETERMINE RATIONAL DESIGN FEATURES AND PARAMETERS OF THE MODES RELATIVE TO THE SCREW DRUMS FOR MIXING ANIMAL FEED

    Directory of Open Access Journals (Sweden)

    Marchenko A. Y.

    2016-06-01

    Full Text Available The authors have developed and manufactured a large number of different designs of relative helical drums for mixing animal feed. We have conducted 749 field experiments with the drums of the 10 different designs with different parameters modes of operation. In all experiments, we measured the quality of the feed mixture. However, directly based on empirical data, rational choice of design features and parameters of the operation modes of the reels is not possible. For this, you must first develop a model reflecting these empirical data. The construction of meaningful analytical models of different types of drums is a difficult and demanding scientific task, the complexity of which is due to the large variety and complexity of forms of drums and their mode of usage, a large number of diverse physical factors affecting the processes in the drum. As a consequence, the development of analytical models associated with a large number of simplifying assumptions that reduce their versatility and reliability. Therefore, it is important to search of a mathematical method and software tools provide a quick and simple for the user to identify and influence the design of the drum and the parameters of the operating modes on the quality of the feed mixture directly on the basis of empirical (experimental data. The work proposes a solution to this problem with the use of a new universal innovative method of artificial intelligence: automated system-cognitive analysis (ASC-analysis and its programmatic Toolkit – universal cognitive analytical system called "Eidos". In the system of "Eidos" we have implemented a software interface that provides direct input into the system large amounts of empirical data from Excel file. Created on their basis in the system of "Eidos" system-cognitive model allows the visual form to reflect the effect of the structure of the drum and the parameters of the operating modes on the quality of the resulting feed mixture and to

  13. 现代汉语借词现象研究%The Study of Lexical Borrowing in Modern Chinese

    Institute of Scientific and Technical Information of China (English)

    师文杰

    2006-01-01

    随着现代汉语中外来词汇数量的不断增加,现代汉语借词现象得到学者们的关注.笔者主要研究了英语缩略字母词被借用到现代汉语这一语言现象以及学者们对英语缩略字母词的讨论和争议.国家语言文字委员会针对这一现象制定出了相关法律.笔者认为:随着国际交流的不断增加,语言之间的相互影响也会日益明显突出,汉语也会不同程度地影响其他语言;这为语言研究者,尤其是社会语言学研究者带来了新的研究领域和课题.%Borrowed lettered words have been increasing in modern Chinese with China's opening to the outsideworld and English language used more extensively and frequently in cross-cultural communication,which brought about a series of heated argument among scholars and language specialists whose viewpoints and attitudes to this language phenomenon vary from one to another.The paper presents an objective analysis of the arguments on lettered word,concluding that languages are interactive,mutually influencing and ever changing,which provides more research resources for linguists and brings more challenges for language commissions.

  14. Describing the organisational culture of a selection of community pharmacies using a tool borrowed from social science.

    Science.gov (United States)

    Scahill, Shane; Harrison, Jeff; Carswell, Peter

    2010-02-01

    To describe the dimensions of organisational culture within a selection of community pharmacies. Community pharmacy in the New Zealand primary care sector which is partially government funded and currently undergoing major reform. Community pharmacy is under pressure to take on new roles, integrate within the wider primary care team and deliver the expectations of contemporary health policy. The mixed methods approach of concept mapping was undertaken with 10 representatives from six community pharmacies selected as case sites. The process was split into three parts (a) face to face brainstorming to generate statements describing culture, followed by (b) statement reduction, piloting and approval of statement list by participants, followed by (c) sorting the statements into 'like' groups. Multidimensional scaling analysis of participant sorting allows the development of discrete clusters of statements that describe aspects of organizational culture. A set of 105 statements were generated at the brainstorming meeting. Eight clusters of organisational culture resulted from participant sorting: leadership and staff management; valuing each other and the team; free thinking, fun and open to challenge; trusted behaviour; customer relations; focus on external integration; providing systematic advice; embracing innovation. Community pharmacy is under pressure to take on new roles and deliver and there is some evidence organisational culture of pharmacy may be a barrier. Our paper outlines the development of a survey instrument for describing organisational culture through Concept mapping, a tool borrowed from social sciences. This tool can be used for exploration of aspects of culture that may be important in the change management process for improving the effectiveness of community pharmacy as expected by contemporary primary health care policy.

  15. DETECTION OF REPORTS FALSIFICATION PROVIDED TO A BANK BY A BORROWER USING THE METHOD OF DYNAMIC PARAMETERS ANALYSIS

    Directory of Open Access Journals (Sweden)

    M. S. Lyuft

    2015-01-01

    Full Text Available Summary. The main stop-factors in a landing were formed in the article according to the procedure of the European Bank for Reconstruction and Development by the means of questioning the leading Russian banks that finance small-scale business. It is given the description of this method, also it is identified the main weaknesses of the EBRD methodology. There is a description of the main methods of the borrowing company’s analytical balance and thereupon it is made the conclusion about the necessity of the analysis of the balance’s principal factors across time. The analysis of indicators and factors in the dynamics enables us to see trends in the development of the company, and to identify deviations in the coefficients. Either materiality or difference from normal values of these coefficients may indicate the factors of the borrowers’ misconduct, and in particular it gives evidence concerning falsification of reports provided to a bank. There are stages of information processing for falsification’s detection, excluding the interest from decision-makers about the possibility of lending in the results of a transaction. The formula that determinates the value of net profit falsification has been made on basis of dynamic parameters of the analytical balance and the connection with the administrative profit-and-loss report. Further, the article provides the second method of a determination of the net profit falsification already based on data of the parameters in dynamics namely business profitability rate. The process of calculation Payment To Income - payment to income - an indicator, in order to obtain good data on who falsify net income. Are key strengths of this method of identifying and conclusions paragraph article.

  16. Uso do ácido ascórbico no controle do escurecimento do pericarpo de lichia Use of ascorbic acid in the control of browning in the pericarp of lychees

    Directory of Open Access Journals (Sweden)

    Danieele Fabíola Pereira da Silva

    2010-06-01

    Full Text Available Um dos maiores problemas na pós-colheita da lichia é o escurecimento do pericarpo, o qual tem sido atribuído à degradação da antocianina. O objetivo do trabalho foi avaliar o efeito de diferentes doses de ácido ascórbico na prevenção do escurecimento do pericarpo e na manutenção da qualidade pós-colheita de lichia. Frutos de lichieira 'Bengal' com o pericarpo completamente vermelho foram imersos em solução com diferentes doses de ácido ascórbico (0; 5; 10; 15 e 30 mM, por 5 minutos. Após secagem à temperatura ambiente, foram acondicionados em bandejas de poliestireno, armazenados em câmara fria a 5 ± 1,2°C e 90 ± 5% de UR e avaliados a cada 4 dias, durante 12 dias. Observou-se que a perda de massa fresca foi maior nos frutos não tratados com ácido ascórbico. Independentemente da dose, o ácido ascórbico teve pouco efeito na retenção da cor vermelha do pericarpo de lichia. A atividade das enzimas polifenoloxidase e peroxidase no pericarpo foi maior com as menores doses de ácido ascórbico (0; 5 e 10 mM, entretanto observou-se escurecimento a partir do quarto dia no pericarpo dos frutos tratados com este ácido. O ácido ascórbico também não foi eficiente na manutenção da qualidade interna dos frutos.One of the biggest problems in postharvest of lychees is the pericarp browning, which has been attributed to anthocyanins degradation. The purpose of this work was to evaluate the effect of different doses of ascorbic acid to prevent pericarp browning and on the maintenance of postharvest quality of lychees. Fruits of 'Bengal' lychee with completely red pericarp were immersed in solution with different doses of ascorbic acid (0, 5, 10, 15 and 30 mM for 5 minutes. After dried, the fruits were packed in polystyrene trays, stored in cold chamber at 5 ± 1,2°C e 90 ± 5% de RH and evaluated every other 4 days for 12 days. It was observed that the loss of fresh weight was higher in non-treated with ascorbic acid

  17. A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte

    Directory of Open Access Journals (Sweden)

    Letizia Mezzasoma

    2017-01-01

    Full Text Available Interleukin-1β (IL-1β is a pleiotropic cytokine and a crucial mediator of inflammatory and immune responses. IL-1β processing and release are tightly controlled by complex pathways such as NF-kB/ERK1/2, to produce pro-IL-1β, and NALP3/ASC/Caspase-1 inflammasome, to produce the active secreted protein. Dysregulation of both IL-1β and its related pathways is involved in inflammatory/autoimmune disorders and in a wide range of other diseases. Identifying molecules modulating their expression is a crucial need to develop new therapeutic agents. IL-1β is a strong regulator of Brain Natriuretic Peptide (BNP, a hormone involved in cardiovascular homeostasis by guanylyl cyclase Natriuretic Peptide Receptor (NPR-1. An emerging role of BNP in inflammation and immunity, although proposed, remains largely unexplored. Here, we newly demonstrated that, in human THP-1 monocytes, LPS/ATP-induced IL-1β secretion is strongly inhibited by BNP/NPR-1/cGMP axis at all the molecular mechanisms that tightly control its production and release, NF-kB, ERK 1/2, and all the elements of NALP3/ASC/Caspase-1 inflammasome cascade, and that NALP3 inflammasome inhibition is directly related to BNP deregulatory effect on NF-kB/ERK 1/2 activation. Our findings reveal a novel potent anti-inflammatory and immunomodulatory role for BNP and open new alleys of investigation for a possible employment of this endogenous agent in the treatment of inflammatory/immune-related and IL-1β/NF-kB/ERK1/2/NALP3/ASC/Caspase-1-associated diseases.

  18. Comparison of the clinical performance of an HPV mRNA test and an HPV DNA test in triage of atypical squamous cells of undetermined significance (ASC-US)

    DEFF Research Database (Denmark)

    Waldstrom, M; Ornskov, D

    2012-01-01

    The effect of triaging women with atypical squamous cells of undetermined significance (ASC-US) with human papillomavirus (HPV) DNA testing has been well documented. New tests detecting HPV E6/E7 mRNA are emerging, claiming to be more specific for detecting high-grade disease. We evaluated...... the clinical performance of two HPV tests: the Linear Array HPV genotyping test (LA) detecting HPV DNA from 37 oncogenic and non-oncogenic HPV types and the Aptima HPV assay detecting E6/E7 mRNA from 14 oncogenic HPV types....

  19. Efectos de recubrimientos de almidón de yuca, ácido ascórbico, n-acetil-cisteína en la calidad del plátano (musa paradisiaca)

    OpenAIRE

    Palacín Beltrán, José Roberto

    2012-01-01

    El efecto de recubrimientos funcionales sobre la calidad de frutos de plátano Hartón (Musa paradisiaca) fue evaluado en la etapa de poscosecha. Las soluciones fueron preparadas a partir de almidón de yuca comercial (Maniot esculenta) 50 g/L, como plastificantes se usaron glicerol 30 g/L y polietilen glicol@600® 6 g/L, se adicionaron como antipardeantes, ácido ascórbico (AC) 6 g/L, (correspondiente al tratamiento 1 @ tr 1), N@acetil@cisteína (NAC) 8 g/L (concer...

  20. Efeitos do reiki na evolução do granuloma induzido através da inoculação do BCG em hamsters e do tumor ascítico de Ehrlich induzido em camundongos

    OpenAIRE

    2008-01-01

    Estudaram-se os efeitos da influência do Reiki na evolução do granuloma induzido experimentalmente pela inoculação do BCG no coxim plantar de hamsters, assim como os efeitos da mesma terapia em camundongos portadores do tumor ascítico de Ehrlich in vivo e in vitro. No modelo de inflamação granulomatosa crônica, utilizou-se 40 hamsters machos, os quais após serem inoculados com BCG no dia 0 no coxim da pata posterior direita, foram separados em dois grupos contendo 20 animais em cada. Um grupo...

  1. Efeito do ácido ascórbico em massa de pão na presença do ácido tânico - doi: 10.4025/actascitechnol.v32i2.5290

    Directory of Open Access Journals (Sweden)

    Ana Leticia Gomes Saraiva

    2010-07-01

    Full Text Available Pães de farinha de trigo com adição do agente oxidante ácido ascórbico foram elaborados, tentando-se encontrar a concentração de ácido tânico que melhor retivesse o ácido ascórbico, sem afetar significativamente as características reológicas e os principais atributos sensoriais do pão. Os pães foram elaborados com a formulação de pão-padrão. Na primeira etapa, determinou-se a concentração de ácido ascórbico que melhor proporcionasse estabilidade à massa de pão-padrão (300 ppm. Na etapa seguinte, foram utilizadas na formulação da massa-padrão três concentrações diferentes de ácido tânico: 0,10; 0,20 e 0,30%, com a finalidade de se verificar a concentração que melhor retivesse o ácido ascórbico. Os pães foram elaborados com a formulação-padrão. Após o resfriamento dos pães, foi avaliada a retenção de ácido ascórbico, presente no pão de acordo com a concentração previamente determinada. Os resultados indicaram que o pão elaborado com a massa de pão-padrão (300 ppm de ácido ascórbico apresentou concentração de ácido ascórbico de 41,50 mg 100 g-1 de pão.

  2. Tax Incentives and Borrowing

    DEFF Research Database (Denmark)

    Alan, Sule; Leth-Petersen, Søren; Munk-Nielsen, Anders

    2016-01-01

    We estimate the effect of a Danish 1987 tax reform, which reduced the tax rate applied to interest deductions from 73% to 50% for households with high incomes, but less for households with middle or low incomes. Using high quality panel data we find that households responded to the reduced tax su...

  3. Tax Incentives and Borrowing

    DEFF Research Database (Denmark)

    Alan, Sule; Leth-Petersen, Søren; Munk-Nielsen, Anders

    2016-01-01

    We estimate the effect of a Danish 1987 tax reform, which reduced the tax rate applied to interest deductions from 73% to 50% for households with high incomes, but less for households with middle or low incomes. Using high quality panel data we find that households responded to the reduced tax...... subsidy by lowering interest payments and we find that the responsiveness to the tax subsidy varies by the initial level of interest payments....

  4. Borrowed Quantifiers in Dunhuang Medical Volume%敦煌医籍中的借用名量词

    Institute of Scientific and Technical Information of China (English)

    王亚丽

    2011-01-01

    敦煌医籍尤其医方类卷子涉及的量词颇多,且部分卷子不见于传世古籍,作为研究量词的极为宝贵的第一手资料,具有极高的语料价值。通过考察敦煌医籍中的23个借用名量词,发现借用名量词大多相对稳定,但时代的变化使一部分量词称量范围扩大或缩小,或者出现新的量词。障为医籍的特殊性,出现了同时代别的文献少见或未见的量词,或者剐的文献中已有的量词但在医籍中称量对象不同。因而或可作修正旧说确立新说之用,或可更为全面地反映唐五代及唐五代以前的量词用法。%There are many quantifiers in Dunhuang medical books, especially in medical and formulae volumes and some volumes is not seen in the ancient masterpieces, for studying quantifiers and having great linguistic value. thus making them extreme valuable first-hand information There were 23 borrowed qualifiers in Dunhuang medical hooks and most of them were stable; however, the some of their weighing scope expanded or reduced due to chan ging time and some new qualifiers also appeared. Due to the special nature of medical books, there were some quali- fiers barely seen of scarcely seen in the contemporary literature or some qualifiers appeared in other literature but shared different weighing objects in medical books. Therefore, they can be either corrected to form new theory or to completely reflect qualifiers usage in and before Tang and Five Dynasties.

  5. Evaluation of Bajo Blanco Sandbar as a Potential Beach Nourishment Borrow Site for Eroding Beaches in Rincon, Puerto Rico

    Science.gov (United States)

    Rojas, C. A.; Canals, M.

    2016-02-01

    The municipality of Rincón, Puerto Rico is recognized for its world-class surfing beaches. Unfortunately, the coast from Punta Higüero to Punta Cadena in Rincón is experiencing long-term erosion (Thieler 2007), which has caused the destruction of many beachfront homes and hotels and had negative impacts on the local tourism-driven economy. The purpose of this project is to evaluate whether the nearby Bajo Blanco sandbar, located just offshore of these eroded beaches, could be used as a possible beach nourishment borrow site. A high-resolution bathymetric survey of Bajo Blanco sandbar was conducted along with a grain size analysis to compare the grain size distribution of the Bajo Blanco sandbar with the sediment properties of the eroded beaches. It was found that the sediment from Bajo Blanco is finer yet may be suitable as beach fill material for these beaches according to Dean's overfill ratio. Compatibility analysis suggests a total volume of sandbar sediment of approximately 685,555 cubic meters to allow successful beach equilibrium. To evaluate the potential effects of the sand extraction on the nearshore wave climate, numerical simulations were performed using the spectral wave model of the USACE Coastal Modeling System (CMS-Wave). Wave model results for several dredging scenarios suggest that wave energy flux concentrates around the shoal causing an increase in wave height at the northern and southern edges of the shoal. Therefore, conservation of energy leads to a reduction of wave energy flux shoreward of the shoal, causing a shadow of reduced wave height. In addition, the Tres Palmas Marine reserve is located just north of Bajo Blanco sandbar and features some of the healthiest Elkorn Corals in the Caribbean. To avoid excessive sedimentation of these reefs during dredging activities, the Particle Tracking Module (PTM), integrated in the Surface-water Modeling System (SMS), was used to evaluate the Lagrangian particle transport processes along Bajo

  6. OPTIMAL INVESTMENT CONSUMPTION MODEL WITH A HIGHER INTEREST RATE FOR BORROWING%高贷款利率的最优消费投资模型

    Institute of Scientific and Technical Information of China (English)

    费为银; 吴让泉

    2000-01-01

    This paper considers a consumption and investment decision problem with a higher in terest rate for borrowing as well as the dividend rate. Wealth is divided into a riskless asset and risky asset with logrithmic Brownian motion price fluctuations. The stochastic control problem of maximizating expected utility from terminal wealth and consumption is studied. Equivalent conditions for optimality are obtained. By using duality methods ,the existence of optimal portfolio consumption is proved ,and the explicit solutions leading to feedback formulae are derived for deteministic coefficients.

  7. The role of lenders' trust in determining borrowing conditions for sovereign debt: An analysis of one-period government bonds with default risk

    OpenAIRE

    Guo, Yanling

    2015-01-01

    In this paper, the author considers the sovereign debt in the form of one-period government bonds with default risk, which can be purchased by and traded among domestic and foreign investors. She shows that the weight assigned to the lenders' interest by the borrowing government at the time of debt repayment, which captures the lenders' trust in the government's propensity to repay the debt and is denoted as », also determines the default risk: a higher » means a lower default risk ceteris pa...

  8. Formal Variability of Terms in the Sphere of Network Technologies

    Directory of Open Access Journals (Sweden)

    Roman Viktorovich Deniko

    2015-09-01

    Full Text Available The article addresses the problem of formal variability of terms in the sphere of network terminology in the Russian language. The research is based on data from the Internet communication in the sphere of network technologies. Such formal variability types as graphical, phonemic, word building and complex (graphic and phonetic, morphologic and accentual are discussed in this article. The authors reveal the reasons for graphic variability of foreign origin terms making up the international terminological fund. These reasons cover such aspects as the use of graphics of source language and recipient language; the presence or absence of hyphenation, etc. It is determined that the phonemic variants of terms appear as a result of oral or written borrowings. The existence of such variants is also connected with the stage of their adaptation in the Russian language after borrowing. In this case the variants are related with soft or hard pronunciation of consonants. There are also some cases of phonemic variability on the graphic level. The complex variability is regarded as a part of active processes taking place in the modern Russian language, and these processes involve both native and foreign origin terms. The particular attention is paid to the word-building variants – word-building affixes the variability of which is peculiar of network technologies. The results of the research show that the variability of professional units belonging to the network technologies sublanguage is caused by the active process of borrowing of specialpurpose vocabulary into the Russian language. The process is due to the intensification of intercultural communication in the professional spheres.

  9. Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H Cytological Lesions with Proved CIN2+

    Directory of Open Access Journals (Sweden)

    Jean-Christophe Noël

    2015-01-01

    Full Text Available Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+. However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV screening. This study aims to evaluate the performance of the high-risk HPV hybrid capture II detection kit (HCII which is considered as a “gold standard technique” in a series of 100 women having proved both cytological lesions of atypical squamous cells-cannot exclude an HSIL (ASC-H or high-grade squamous intraepithelial lesion (HSIL and histological lesions of CIN2+. The clinical sensitivity of HCII in women with a cytological diagnosis of ASC-H/HSIL and a diagnosis of CIN2+ is high but not absolute and estimated at 96% (95,6% and 100% of women with a diagnosis of CIN2/3 or invasive squamous cell carcinoma, resp.. These data although they are infrequent must be clearly referred before to start an HPV primary screening of CIN2+ especially with HCII methodology.

  10. Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses

    Science.gov (United States)

    Nawrocka, Daria; Kornicka, Katarzyna; Śmieszek, Agnieszka

    2017-01-01

    Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)—the first-line cells exposed to dietary compounds. In the conducted research, we showed that in vitro application of Spirulina platensis contributes to the restoration of ASCs’ and IECs’ morphology and function through the reduction of cellular oxidative stress and inflammation. Enhanced viability, suppressed senescence, and improved proliferation of ASCs and IECs isolated from metabolic syndrome-affected individuals were evident following exposition to Spirulina. A protective effect of the investigated extract against mitochondrial dysfunction and degeneration was also observed. Moreover, our data demonstrate that Spirulina extract effectively suppressed LPS-induced inflammatory responses in macrophages. In vivo studies showed that horses fed with a diet based on Spirulina platensis supplementation lost weight and their insulin sensitivity improved. Thus, our results indicate the engagement of Spirulina platensis nourishing as an interesting alternative approach for supporting the conventional treatment of equine metabolic syndrome. PMID:28771165

  11. A Discussion on Collateral Obligation about Borrowing Contract of Readers%读者借阅合同中的附随义务探析

    Institute of Scientific and Technical Information of China (English)

    孙强

    2015-01-01

    The collateral obligation about borrowing contract of readers occurs in the development process and a certain period after the termination of this contract, in accordance with the principle of honesty and to maintain each other's interests, and belong to the burden outside payment obligation payed by the party. It include prior contract obligation, collateral obligation in performing the contract , post contract obligation. Combining with readers' borrowing contract I discussed three types of obligations their respective connotation and containing content, and analyzed the responsibility in violation of three types obligations.%读者借阅合同中的附随义务发生于读者借阅合同发展进程中及终止后的一定时期,是依照诚实信用原则为维护对方利益,由当事人负担的给付义务以外的义务,包括先合同义务、合同履行中的附随义务、后合同义务.文章结合读者借阅合同对三类义务各自内涵及包含内容作了探讨,并对违反三类义务所产生的责任承担作了分析.

  12. Actividad antioxidante, compuestos fenólicos y ácido ascórbico de frutillas en dos sistemas de producción Antioxidant activity, phenolic compounds and ascorbic acid content in strawberries from two crop production systems

    Directory of Open Access Journals (Sweden)

    Rufino Fernando F Cantillano

    2012-12-01

    Full Text Available El objetivo de este trabajo fue determinar la influencia del sistema de producción y del período de almacenamiento de frutillas sobre la pérdida de masa, compuestos fenólicos totales, antocianinas totales, ácido ascórbico (vitamina C, actividad antioxidante y sus correlaciones. En este experimento fueron utilizadas frutillas 'Camarosa' y 'Camino Real' con madurez comercial, procedentes de cultivos en sistemas de producción orgánico y convencional, localizados en el municipio de Pelotas-RS. Los frutos fueron almacenados durante 0, 2, 5 y 8 días a 1ºC y 90-95% de HR. En general, el contenido de fenoles totales, de antocianinas totales y la actividad antioxidante aumentaron durante el almacenamiento refrigerado, mientras que los contenidos de ácido ascórbico y de masa fresca disminuyeron significativamente. Los contenidos de fenoles totales y de antocianinas totales presentaron correlación positiva con la actividad antioxidante, siendo la correlación con el contenido de ácido ascórbico negativa. Las frutillas producidas en sistema orgánico y conservadas durante cinco días, mostraron mayores valores de actividad antioxidante. Después de ocho días de almacenamiento a 1ºC, los frutos del sistema de producción orgánico presentaron menor degradación de antocianinas y de ácido ascórbico que los frutos del sistema de producción convencional.The aim of this study was to determine the influence of the crop production system and storage period on weight loss, total phenolic content, total anthocyanin content, ascorbic acid (vitamin C content, and antioxidant activity in strawberries, as well as their correlations. For this experiment, strawberry fruits of 'Camarosa' and 'Camino Real' at commercial maturity from both organic and conventional crop production systems located in Pelotas, Brazil, were used. The fruits were cold stored for 0, 2, 5, and 8 days at 1ºC and 90-95% RH. In general the total phenolic, total anthocyanin levels

  13. State and socio-demographic group variation in out-of-pocket expenditure, borrowings and Janani Suraksha Yojana (JSY programme use for birth deliveries in India

    Directory of Open Access Journals (Sweden)

    Modugu Hanimi Reddy

    2012-12-01

    Full Text Available Abstract Background High out-of-pocket-expenditure (OOPE deters families from seeking skilled/institutional care. ‘Janani Suraksha Yojana (JSY, a conditional cash transfer programme launched in 2005 to mitigate OOPE and to promote institutional deliveries among the poor, is part of Government of India’s efforts to achieve Millennium Development Goals (MDGs 4 and 5. The objective of this study is to estimate variations in OOPE for normal/caesarean-section deliveries, JSY-programme use and delivery associated borrowings - by states and union territories, and socio-demographic profiling of families, in India. Methods Secondary analysis of data from the District Level Household Survey (DLHS-3, 2007–08. Mean and median OOPE, percentage use of JSY and percentage of families needing to borrow money to pay for delivery associated expenditure was estimated for institutional and home deliveries. Results Half (52% of all deliveries in India occurred at home in 2007/08. OOPE for women having institutional deliveries remained high, with considerable variation between states and union territories. Mean OOPE (SD of a normal delivery in public and private institution respectively in India were Rs. 1,624 and Rs. 4,458 and for a caesarean-section it was Rs. 5,935 and Rs. 14,276 respectively. There was considerable state-level variation in use of the JSY programme for normal deliveries (15% nationally; ranging from 0% in Goa to 43% in Madhya Pradesh and the percentage of families having to borrow money to pay for a caesarean-section in a private institution (47% nationally; ranging from 7% in Goa to 69% in Bihar. Increased literacy and wealth were associated with a higher likelihood of an institutional delivery, higher OOPE but no major variations in use of the JSY. Conclusions Our study highlights the ongoing high OOPE and impoverishing impact of institutional care for deliveries in India. Supporting families in financial planning for maternity care

  14. Filmes plásticos e ácido ascórbico na qualidade de araticum minimamente processado Plastic packaging film and ascorbic acid treatment on the quality of fresh cut araticum

    Directory of Open Access Journals (Sweden)

    Manoel Soares Soares Júnior

    2007-12-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos do ácido ascórbico e do tipo de filme plástico como embalagem na qualidade do araticum minimamente processado e mantido sob refrigeração. O ácido ascórbico não evitou o escurecimento do araticum minimamente processado. Independentemente do tipo de embalagem, a acidez titulável aumentou com o tempo. A embalagem de policloreto de vinila ou polietileno de baixa densidade promoveu uma significativa perda de massa se comparada com a a laminada a vácuo. A embalagem laminada a vácuo propiciou vida-de-prateleira mais longa ao produto, o qual permaneceu com aparência adequada e qualidade comercial até o sétimo dia do armazenamento. A vida-de-prateleira dos demais tratamentos alcançou somente três dias.This study was aimed at evaluating the effect of ascorbic acid and type of plastic packaging film on the quality of refrigerated fresh cut araticum. Ascorbic acid did not prevent fresh cut araticum from darkening. Regardless of the type of plastic packaging, the fruit titrable acidity increased with time. Packing with polyvynil chloride or with low density polyethylene promoted a significant mass loss compared to laminate vacuum packaging. Laminate vacuum packaging increased the shelf life of the product up 7 days, maintaining its commercial quality and appearance. The shelf life of the other treatments reached 3 days only.

  15. Avaliação da interferência do ácido ascórbico na detecção da glicosúria Evaluation of ascorbic acid interference in the detection of glycosuria

    Directory of Open Access Journals (Sweden)

    Jaime Murilo Fernandes Costa

    2012-02-01

    Full Text Available INTRODUÇÃO: O ácido ascórbico (vitamina C é comumente ingerido como suplemento vitamínico. É uma vitamina hidrossolúvel, excretada pela urina e pode interferir nos ensaios laboratoriais, como nas reações de oxirredução para detecção da glicosúria. OBJETIVO: Este trabalho tem como objetivo avaliar a interferência do ácido ascórbico na detecção de glicosúria pelo método de química seca por meio do uso de tiras reagentes. MATERIAIS E MÉTODOS: Amostras de urina foram avaliadas no analisador da marca Clinitek Atlas (Siemens Healthcare Diagnostics Inc., EUA. Foram selecionadas quatro amostras de urina com diferentes concentrações de glicose: 100 mg/dl, 250 mg/dl, 500 mg/dl e 1.000 mg/dl. Para cada concentração de glicose foram criadas cinco alíquotas, adicionando-se uma solução de ácido ascórbico 200 mg/dl, suficiente para obter uma concentração final de ácido ascórbico de 20 mg/dl no primeiro tubo, de 50 mg/dl no segundo tubo, de 270 mg/dl no terceiro tubo, de 1.000 mg/dl no quarto tubo e de 2.000 mg/dl no quinto tubo. Após essa adição, as amostras foram novamente avaliadas no analisador Clinitek Atlas. RESULTADOS: Nas amostras com concentração de 20 mg/dl de ácido, não se evidenciou interferência. Nas concentrações iguais e acima de 50 mg/dl, a interferência do ácido ascórbico se fez presente, sendo que o fato foi caracterizado pelos resultados falso negativos para detecção da glicose urinária. CONCLUSÃO: Os resultados demonstraram a interferência do ácido ascórbico no método da química seca (tiras reagentes, subestimando o nível de glicose urinária.INTRODUCTION: Ascorbic acid (vitamin C is commonly used as a vitamin supplement. It is a water soluble vitamin, which is excreted through urine and may interfere in laboratory tests as well as redox reactions for urinary glucose detection. OBJECTIVE: This study aims to assess ascorbic acid interference in glycosuria detection by dry chemistry

  16. INCOME INEQUALITY AND HOUSEHOLD BORROWING---Does the Motivation of Household Borrowing for Social Status Exist%收入不平等与家庭借贷行为*--家庭为追求社会地位而借贷的动机真的存在吗

    Institute of Scientific and Technical Information of China (English)

    郭新华; 刘辉; 伍再华

    2016-01-01

    本文利用中国家庭金融调查(CHFS)2011年度的调查数据,考察了收入不平等对家庭借贷行为的影响,并验证了家庭是否存在为追求社会地位而借贷的动机。研究表明:(1)收入不平等并不是影响家庭是否借贷的主要因素,但是对家庭的负债规模存在十分显著的抑制作用;(2)收入不平等的扩大并不会促使中低收入家庭寻求借贷或提升家庭负债规模,我国家庭并不存在为了追求更高的社会地位而进行借贷的动机;(3)收入不平等的扩大有利于高收入家庭获得更多的正规金融借贷,中低收入家庭则会较多地依赖于非正规金融借贷;(4)户主的人口统计学特征、家庭经济特征以及家庭所处地区特征均是影响家庭借贷行为的重要因素,在正规金融和非正规金融市场上,影响家庭借贷行为的因素存在较明显的差异。%Using the data of 2011 China Household Finance Survey (CHFS),this paper investigates the effect of income inequality on household debt and verifies the existence of household�s motivation bor-rowing for social status in China.Our research results show as follows:(1)Income inequality is not a ma-jor factor whether the household to borrow or not,but it can cause the inhibition of the scale in debt. (2)The broaden of income inequality does not make low-income families attempt to seek loans or enhance the size of household debt.Chinese family has no motives for pursuing a higher social status to borrow. (3)The broaden of income inequality benefits the high-income families to get more formal financial bor-rowing.Low-income families will be more dependent on the informal financial borrowing. (4)The demo-graphic characteristics of the head of household,economic characteristics of households and their locations are the important factors that affect household borrowing behavior,and there are more obvious differences between factors that influence the formal

  17. THE USE OF ENGLISH-LOAN WORDS IN THE INFORMATION TECHNOLOGY DOMAIN

    Directory of Open Access Journals (Sweden)

    Abrudan Caciora Simona Veronica

    2015-07-01

    Full Text Available This paper examines the phenomenon of linguistic borrowings in general and the use of anglicisms in particular, in the contexts of globalization and the progress made in different domains, especially in the Information Technology domain. Borrowing is the phenomenon which undertakes the word transmission process from one language into another among the connected communities. The language that lends is the donor or the borrower language, and the language that borrows is known as the receptor or the borrowing language. Anglicisms are the English-loan words that are present in many European languages. The phenomenon of globalisation is the main topic of several contradictory and polarization discussions and undoubtedly globalisation is necessary and it is a fact in today’s world but the question is: what will be the long-term language consequences? There might be two situations: the consequences may be positive, such as ease of communication and perception, language economics and also negative: not understanding anglicisms resulting in disturbed communication, rejection of anglicisms, loss of semantic diversity of your own language, less and less possibilities of expressing yourself in your own language. We can mention that responsible for the impact of English is the prestige associated with this language. This language is generally held in highest regard by the younger generation of Romanians, who are easily influenced by the television, radio, movies, and other media that are supplied by British and American entertainment, which are considered to be trendy and cool. Each of those resources has influenced the Romanian population on numerous levels, creating new words and phrases in the Romanian language. In order to illustrate and discuss the pertinent or, on the contrary, the unjustified use of English-loan words in the field of Information Technology, the study will focus on a selection of articles published in the electronic Romanian issues

  18. Catalytic enantioselective amination of alcohols by the use of borrowing hydrogen methodology: cooperative catalysis by iridium and a chiral phosphoric acid.

    Science.gov (United States)

    Zhang, Yao; Lim, Ching-Si; Sim, Derek Sui Boon; Pan, Hui-Jie; Zhao, Yu

    2014-01-27

    The catalytic asymmetric reduction of ketimines has been explored extensively for the synthesis of chiral amines, with reductants ranging from Hantzsch esters, silanes, and formic acid to H2 gas. Alternatively, the amination of alcohols by the use of borrowing hydrogen methodology has proven a highly atom economical and green method for the production of amines without an external reductant, as the alcohol substrate serves as the H2 donor. A catalytic enantioselective variant of this process for the synthesis of chiral amines, however, was not known. We have examined various transition-metal complexes supported by chiral ligands known for asymmetric hydrogenation reactions, in combination with chiral Brønsted acids, which proved essential for the formation of the imine intermediate and the transfer-hydrogenation step. Our studies led to an asymmetric amination of alcohols to provide access to a wide range of chiral amines with good to excellent enantioselectivity.

  19. Policy Borrowing and Transfer, and Policy Convergence: Justifications for the Adoption of the Bologna Process in the CEMAC Region and the Cameroonian Higher Education System through the LMD Reform

    Science.gov (United States)

    Eta, Elizabeth Agbor

    2015-01-01

    The borrowing and transfer of policies, ideas and practices from one system to another may in part explain the convergence of educational systems. Using text documents as research material, this paper examines the adoption and transfer of Bologna Process (BP) ideas in the Economic and Monetary Community of Central Africa (CEMAC) and in the…

  20. Policy Borrowing and Transfer, and Policy Convergence: Justifications for the Adoption of the Bologna Process in the CEMAC Region and the Cameroonian Higher Education System through the LMD Reform

    Science.gov (United States)

    Eta, Elizabeth Agbor

    2015-01-01

    The borrowing and transfer of policies, ideas and practices from one system to another may in part explain the convergence of educational systems. Using text documents as research material, this paper examines the adoption and transfer of Bologna Process (BP) ideas in the Economic and Monetary Community of Central Africa (CEMAC) and in the…

  1. Keep Floating; Rising interest rates have upset many floating rate borrowers. But it doesn't make sense to switch to a fixed rate now as rates are expected to plunge

    National Research Council Canada - National Science Library

    Sushmita Choudhury

    2006-01-01

    .... If there is anybody smiling through all this it is the fixed rate borrowers. They don't have to worry about rising interest rates because everything in their loan is fixed-the interest rate, the EMI and the term...

  2. Three essays on resource economics. Demand systems for energy forecasting: Practical considerations for estimating a generalized logit model, To borrow or not to borrow: A variation on the MacDougal-Kemp theme, and, Valuing reduced risk for households with children or the retired

    Science.gov (United States)

    Weng, Weifeng

    This thesis presents papers on three areas of study within resource and environmental economics. "Demand Systems For Energy Forecasting" provides some practical considerations for estimating a Generalized Logit model. The main reason for using this demand system for energy and other factors is that the derived price elasticities are robust when expenditure shares are small. The primary objective of the paper is to determine the best form of the cross-price weights, and a simple inverse function of the expenditure share is selected. A second objective is to demonstrate that the estimated elasticities are sensitive to the units specified for the prices, and to show how price scales can be estimated as part of the model. "To Borrow or Not to Borrow: A Variation on the MacDougal-Kemp Theme" studies the impact of international capital movements on the conditional convergence of economies differing from each other only in initial wealth. We found that in assets, income, consumption and utility, convergence obtains, with and only with, the absence of international capital movement. When a rich country invests in a poor country, the balance of debt increases forever. Asset ownership is increased in all periods for the lender, and asset ownership of the borrower is deceased. Also, capital investment decreases the lender's utility for early periods, but increases it forever after a cross-over point. In contrast, the borrower's utility increases for early periods, but then decreases forever. "Valuing Reduced Risk for Households with Children or the Retired" presents a theoretical model of how families value risk and then exams family automobile purchases to impute the average Value of a Statistical Life (VSL) for each type of family. Data for fatal accidents are used to estimate survival rates for individuals in different types of accidents, and the probabilities of having accidents for different types of vehicle. These models are used to determine standardized risks for

  3. Efeito do tratamento térmico na concentração de carotenóides, compostos fenólicos, ácido ascórbico e capacidade antioxidante do suco de tangerina murcote Effect of thermal treatment on the carotenoid, phenolic compound and ascorbic acid concentrations, and the antioxidant capacity of murcott tangerine juice

    National Research Council Canada - National Science Library

    André de Souza Dutra; Angela Aparecida Lemos Furtado; Sidney Pacheco; João Oiano Neto

    2012-01-01

    ... relação ao teor de carotenóides totais, ao perfil de carotenóides (luteína, zeaxantina, β-criptoxantina e β-caroteno), aos compostos fenólicos totais, ao ácido ascórbico e à capacidade antioxidante...

  4. Supporting Technology at GRC to Mitigate Risk as Stirling Power Conversion Transitions to Flight

    Science.gov (United States)

    Schreiber, Jeffrey G.; Thieme, Lanny G.; Wong, Wayne A.

    2009-01-01

    Stirling power conversion technology has been reaching more advanced levels of maturity during its development for space power applications. The current effort is in support of the Advanced Stirling Radioisotope Generator (ASRG), which is being developed by the U.S. Department of Energy (DOE), Lockheed Martin Space Systems Company (LMSSC), Sunpower Inc., and the NASA Glenn Research Center (GRC). This generator would use two high-efficiency Advanced Stirling Convertors (ASCs) to convert thermal energy from a radioisotope heat source into electricity. Of paramount importance is the reliability of the power system and as a part of this, the Stirling power convertors. GRC has established a supporting technology effort with tasks in the areas of reliability, convertor testing, high-temperature materials, structures, advanced analysis, organics, and permanent magnets. The project utilizes the matrix system at GRC to make use of resident experts in each of the aforementioned fields. Each task is intended to reduce risk and enhance reliability of the convertor as this technology transitions toward flight status. This paper will provide an overview of each task, outline the recent efforts and accomplishments, and show how they mitigate risk and impact the reliability of the ASC s and ultimately, the ASRG.

  5. 植被客土层对黄土边坡降雨人渗影响试验研究%Study on the Influence of Vegetation Borrowed Soil on Rainfall Infiltration of Loess Slope

    Institute of Scientific and Technical Information of China (English)

    李守升

    2011-01-01

    降雨入渗使得非饱和土边坡内含水量增大,进而使土的抗剪强度降低,这是降雨诱发浅层边坡失稳的重要原因之一.在适用于黄土地区的Green-Ampt入渗模型的基础上提出了考虑客土层的入渗模型,并分析了客土对入渗性能的影响.结果表明:客土配比对湿润锋深度和累积入渗量均有较大影响;客土渗透系数对湿润锋深度和累积入渗量都有明显影响,而客土饱和体积含水量只对累积入渗量有较小影响;在模型分析的基础上提出了客土配比所满足的条件.%Rainfall filtration makes water content in unsaturated soil slope increased and the shear resistance of soil decreased, which is one of the major reasons of shadow slope instability caused by rainfall.In this paper,based on Green-Ampt model applicable for loess area, the filtration model of loess slope considering borrowed soil layer is advanced and the influence of borrowed soil on slope filtration is analyzed.The result shows that borrowed soil proportion has larger influence on wetting front depth and accumulated filtration capacity, which are significantly affected by the filtration coefficient of borrowed soil, but little affected by saturated water content.Therefore, the requirements for borrowed soil proportion are put forward based on model analysis.

  6. Should ascitis volume and anthropometric measurements be estimated in hospitalized alcoholic cirrotics? ¿Es conveniente estimar el volumen ascítico y las medidas antropométricas en pacientes hospitalizados cirróticos?

    Directory of Open Access Journals (Sweden)

    E. M. Silva

    2012-12-01

    Full Text Available Introduction: Ascitis and undernutrition are frequent complications of cirrhosis, however ascitis volume and anthropometric assessment are not routinely documented or considered in prognostic evaluation. In a homogeneous cohort followed during two years these variables were scrutinized, aiming to ascertain relevance for longterm outcome. Methods: Population (N = 25, all males with alcoholic cirrhosis was recruited among patients hospitalized for uncomplicated ascitis. Exclusion criteria were refractory or tense ascitis, cancer, spontaneous bacterial peritonitis, bleeding varices and critical illness. Measurements included ultrasonographically estimated ascitis volume, dry body mass index/BMI , upper arm anthropometrics, hematologic counts and liver function tests. Results: Population (age 48.3 ± 11.3 years, BMI 21.1± 3.5 kg/m², serum albumin 2.5 ± 0.8 g/dL was mostly in the Child-Pugh C category (77.8% but clinically stable. During the follow-up period of 22.6 ±3.8 months, additional hospitalizations numbered 1.7 ± 1.0 and more than one quarter succumbed. Admission ascitis volume corresponded to 7.1 ± 3.6 L and dry BMI to 18.3 ± 3.5 kg/m². Child Pugh index was relevant for both mortality and rehospitalization. Nevertheless, similar matches for mortality were documented with ascitis volume and dry BMI, and arm circumference below the 5th percentile was highly significantly associated with rehospitalization. Conclusions: A greater association than hitherto acknowledged, between ascitis volume and anthropometric measurements from one side, and long-term rehospitalization and mortality from the other, was demonstrated in male stable alcoholic cirrhotics. Further studies with alcoholic and other modalities of cirrhosis including women are recommended.Introducción: Ascitis y desnutrición son complicaciones frecuentes de la cirrosis, pero el volumen ascítico y la evaluación antropométrica no son como rutina documentadas o consideradas

  7. Determination by HPLC of ascorbic acid and tocopherols in fruits / Determinação de ácido ascórbico e tocoferóis em frutas por CLAE

    Directory of Open Access Journals (Sweden)

    Rui Carlos Zambiazi

    2010-07-01

    cido ascórbico e de tocoferóis, de seleções de pitanga (Eugenia uniflora L., butiá (Butiá capitata, amora-preta (Rubus spp, mirtilo (Vaccium ashei Reade, nêspera (Eribrotia japônica, jambolão (Eugenia jambolana, araçá roxo (Psidium rufum, physalis (Physalis peruviana, pêra (Pyrus communis e pêssegos (Prunus persica. As frutas utilizadas foram das safras 2006/2007/2008, obtidas na região de Pelotas/RS. A análise dos tocoferóis foi realizada segundo Rodrigues-Amaya (1999, e do ácido ascórbico segundo Vinci, Botre e Ruggieri (1995. A identificação e quantificação dos tocoferóis e do ácido ascórbico foi realizada em um sistema de cromatografia liquída de alta eficiência (CLAE, utilizando detector de fluorescência para os tocoferóis (excitação em 290 nm e emissão em 330 nm e detector de UV-Visível para o ácido ascórbico (254 nm. A amora-preta cv. Tupy apresentou maior teor de tocoferóis (8,251 µg.g-1 de fruta quando comparado ao conteúdo das demais frutas. Na pêra e nos pêssegos cv. Sensação e cv. Granada não identificou-se a presença de tocoferóis. As concentrações de ácido ascórbico variaram de 9,291 mg.g-1 para o physalis à 0,013 mg.g-1 para o jambolão. Conclui-se que as frutas são boas fontes destes compostos bioativos.

  8. Uso de própolis e ácido ascórbico na criopreservação do sêmen caprino Use of propolis and ascorbic acid on goat semen cryopreservation

    Directory of Open Access Journals (Sweden)

    Erick Fonseca de Castilho

    2009-12-01

    Full Text Available Os objetivos neste estudo foram verificar se a própolis e o ácido ascórbico têm efeito sobre a integridade da membrana plasmática dos espermatozoides de caprinos e investigar o potencial desses antioxidantes no uso de meios diluidores de criopreservação de sêmen caprino. Foram utilizados cinco bodes adultos das raças Alpina (n = 2 e Saanen (n = 3. Após a coleta de sêmen, realizaram-se o exame físico do sêmen e morfológico dos espermatozoides, o teste supravital e o teste hiposmótico. Em seguida, o sêmen fresco foi diluído com o diluidor Bioxcell® (controle; Bioxcell® + 0,25% de extrato liofilizado de própolis; Bioxcell® + 0,5% de extrato liofilizado de própolis; Bioxcell® + 0,05% de ácido ascórbico; ou Bioxcell® + 0,25% de ácido ascórbico. Após as diluições finais, foram avaliados a motilidade e o vigor espermático obtidos com cada diluidor e posteriormente o sêmen foi submetido a envase, resfriamento e congelamento. No sêmen fresco, os aspectos físicos e morfológicos e os resultados dos testes supravital e hiposmótico não diferiram entre os animais nem entre raças. As médias gerais de motilidade e vigor espermático e dos testes supravital e hiposmótico obtidos logo após o descongelamento e após 3 horas de teste de termorresistência diferiram entre si, de modo que o diluidor contendo ácido ascórbico e o controle foram similares e superiores àqueles contendo própolis. O ácido ascórbico mantém a integridade estrutural da membrana dos espermatozoides durante o processo de criopreservação, bem como sua viabilidade após o teste de termorresistência, e pode ser uma alternativa na composição de diluentes para criopreservação de sêmen caprino; a própolis não é eficaz na manutenção da integridade e da viabilidade espermática pós-descongelamento e é tóxica aos espermatozoides nas concentrações de 0,25 e 0,5%.The objectives of this study were to verify whether propolis and ascorbic

  9. Progress and goals for INMM ASC N15 consensus standard ""Administrative practices for the determination and reporting of results of non-destructive assay measurements of nuclear material in situ for safeguards nuclear criticality safety and other purposes

    Energy Technology Data Exchange (ETDEWEB)

    Bracken, David S [Los Alamos National Laboratory; Lamb, Frank W [UNWIN CORPORATION

    2009-01-01

    This paper will discuss the goals and progress to date on the development of INMM Accredited Standard Committee (ASC) N15 consensus standard Administrative Practices for the Determination and Reporting of Results of Non-Destructive Assay Measurements of Nuclear Material in situ for Safeguards, Nuclear Criticality Safety, and Other Purposes. This standard will define administrative practices in the areas of data generation and reporting of NDA assay of holdup deposits with consideration of the stakeholders of the reported results. These stakeholders may include nuclear material accounting and safeguards, nuclear criticality safety, waste management, health physics, facility characterization, authorization basis, radiation safety, and site licensing authorities. Stakeholder input will be solicited from interested parties and incorporated during the development of the document. Currently only one consensus standard exists that explicitly deals with NDA holdup measurements: ASTM C1455 Standard Test Method for Nondestructive Assay of Special Nuclear Material Holdup Using Gamma-Ray Spectroscopic Methods. The ASTM International standard emphasizes the activities involved in actually making measurements, and was developed by safeguards and NDA experts. This new INMM ASC N15 standard will complement the existing ASTM international standard. One of the largest driving factors for writing this new standard was the recent emphasis on in situ NDA measurements by the safeguards community due to the Defense Nuclear Facility Safety Board (DNFSB) recommendation 2007-1 on in situ NDA measurements. Specifically, DNFSB recommendation 2007-1 referenced the lack of programmatic requirements for accurate in situ measurements and the use of measurement results for compliance with safety based requirements. That being the case, this paper will also discuss the progress made on the Implementation Plan for Defense Nuclear Facilities Safety Board Recommendation 2007-1 Safety-Related In Situ

  10. Integrating Information and Communication Technology in the Classroom:

    Directory of Open Access Journals (Sweden)

    Bastien Sasseville

    2004-06-01

    Full Text Available The discourse about information technology is often overlooked by researchers and scholars as a means of understanding the recent process of computerization in education. The research explores this phenomenon through a comparative discourse analysis of primary and secondary school teachers and promoters of ICT integration. The results show that promoters tend to view ICT as a way of transforming education whereas teachers see it only as a means to an end. The former's vision is borrowed from a prospective current of thought, a vision of social changes based on technological advances; the latter's considers only the needs of the students and the practical ways to respond to them. The research shows that teachers are not opposed to ICT integration; they're interested in effective ways to implement learning. The organizational context into which ICT is integrated is also a major impediment when it comes to changing the teacher's practice.

  11. CHP Technologies

    Science.gov (United States)

    Learn about CHP technologies, including reciprocating engines, combustion turbines, steam turbines, microturbines, fuel cells, and waste heat to power. Access the Catalog of CHP Technologies and the Biomass CHP Catalog of Technologies.

  12. Assistive Technology

    Science.gov (United States)

    ... Page Resize Text Printer Friendly Online Chat Assistive Technology Assistive technology (AT) is any service or tool that helps ... be difficult or impossible. For older adults, such technology may be a walker to improve mobility or ...

  13. Equine Metabolic Syndrome Affects Viability, Senescence, and Stress Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New Insight into EqASCs Isolated from EMS Horses in the Context of Their Aging.

    Science.gov (United States)

    Marycz, Krzysztof; Kornicka, Katarzyna; Basinska, Katarzyna; Czyrek, Aleksandra

    2016-01-01

    Currently, equine metabolic syndrome (EMS), an endocrine disease linked to insulin resistance, affects an increasing number of horses. However, little is known about the effect of EMS on mesenchymal stem cells that reside in adipose tissue (ASC). Thus it is crucial to evaluate the viability and growth kinetics of these cells, particularly in terms of their application in regenerative medicine. In this study, we investigated the proliferative capacity, morphological features, and accumulation of oxidative stress factors in mesenchymal stem cells isolated from healthy animals (ASCN) and horses suffering from EMS (ASCEMS). ASCEMS displayed senescent phenotype associated with β-galactosidase accumulation, enlarged cell bodies and nuclei, increased apoptosis, and reduced heterochromatin architecture. Moreover, we observed increased amounts of nitric oxide (NO) and reactive oxygen species (ROS) in these cells, accompanied by reduced superoxide dismutase (SOD) activity. We also found in ASCEMS an elevated number of impaired mitochondria, characterized by membrane raptures, disarrayed cristae, and vacuole formation. Our results suggest that the toxic compounds, accumulating in the mitochondria under oxidative stress, lead to alternations in their morphology and may be partially responsible for the senescent phenotype and decreased proliferation potential of ASCEMS.

  14. 大学生乙肝病毒携带者群体心理健康教育的思考与对策%Attempts on strategies towards college AsC psychological counseling

    Institute of Scientific and Technical Information of China (English)

    俞丽琴; 余辉; 胡志红

    2011-01-01

    大学生中的乙肝病毒携带者(AsC)存在多种心理压力,严重影响着他们的身心健康.通过加强校园文化建设、完善医学课程体系、宣传国家政策法规、主动关爱学生等各项有针对性的心理健康教育指导,帮助大学生中的乙肝病毒携带者解除心理压力、促进身心健康.%The psychological stress on college AsC students is significantly influencing their physical and emotional states, which calls for considerable attention and care from related parties.A follow-up counseling needs to be launched to help relieve their psychological stress and live a healthier life, and methods include enriching school culture, perfecting curriculum system, publicizing policies and taking good care of students affected.

  15. Equine Metabolic Syndrome Affects Viability, Senescence, and Stress Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New Insight into EqASCs Isolated from EMS Horses in the Context of Their Aging

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-01-01

    Full Text Available Currently, equine metabolic syndrome (EMS, an endocrine disease linked to insulin resistance, affects an increasing number of horses. However, little is known about the effect of EMS on mesenchymal stem cells that reside in adipose tissue (ASC. Thus it is crucial to evaluate the viability and growth kinetics of these cells, particularly in terms of their application in regenerative medicine. In this study, we investigated the proliferative capacity, morphological features, and accumulation of oxidative stress factors in mesenchymal stem cells isolated from healthy animals (ASCN and horses suffering from EMS (ASCEMS. ASCEMS displayed senescent phenotype associated with β-galactosidase accumulation, enlarged cell bodies and nuclei, increased apoptosis, and reduced heterochromatin architecture. Moreover, we observed increased amounts of nitric oxide (NO and reactive oxygen species (ROS in these cells, accompanied by reduced superoxide dismutase (SOD activity. We also found in ASCEMS an elevated number of impaired mitochondria, characterized by membrane raptures, disarrayed cristae, and vacuole formation. Our results suggest that the toxic compounds, accumulating in the mitochondria under oxidative stress, lead to alternations in their morphology and may be partially responsible for the senescent phenotype and decreased proliferation potential of ASCEMS.

  16. Research on High Efficiency Channel Borrowing Algorithm in Wireless Mobile Communication System%无线移动通信系统中的高效信道借用算法研究

    Institute of Scientific and Technical Information of China (English)

    秦好亮; 曹达仲

    2001-01-01

    本文将固定信道分配(Fixed Channel Assignment)和动态信道分配(Dynamic Channel Assignment)相结合,提出了一种高效信道借用算法HEBCA(High Efficiency Channel Borrowing Algorithm).它利用预期信道可用率(Expected FutureChannel Availahility Rate)衡量信道借用对周围小区的影响,针对信道借用发生和信道借用结束设计了两种重排操作.计算机仿真表明,本算法的阻塞概率低于BDCL(Borrowing with Directional Channel Locking),对改善FCA在业务量低端的性能很有帮助.本算法的信道重排比率(Channel Reallocation Ratto)也明显低于BDCL.

  17. Understanding rapid internationalization of new low-technology ventures from emerging economies

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2012-01-01

    This theory-building study makes an attempt to advance the field of international entrepreneurship that is (i) fragmented and suffers from theoretical paucity, as well as from coverage bias by focusing mostly on high-technology international new ventures from developed economies and (ii) that needs...... to borrow more actively from other disciplines in order for the international entrepreneurship theory to emerge. In this endeavour, the study draws from the institutional theory in order to explore the process of rapid internationalization of new ventures from emerging economies....

  18. Adoção de Cidadãos Presos e Formação de Professores para a Prisão: Ações de Fraternidade Política e Direitos, aproximando a extensão universitária da ASCES e da UFPE no agreste pernambucano. Adoption of inmates and teacher training for prison: Actions of political fraternity and human rights approaching university extension to ASCES and UFPE in the rural area of Pernambuco state, Brazil

    Directory of Open Access Journals (Sweden)

    Jordão, Maria Perpétua S. D.

    2014-08-01

    Full Text Available Este artigo trata de analisar como dois projetos extensionistas – Adoção Jurídica de Cidadãos Presos (ASCES e Formação de Professores para o Sistema Penitenciário (UFPE – possibilitam desde 2001 (ASCES e 2009 (UFPE ações articuladas de cidadania e direitos humanos em uma unidade prisional do agreste de Pernambuco, Brasil. O trabalho foi articulado a partir da participação de professores da ASCES em Grupo de Pesquisa da UFPE-CNPq e da percepção de como a integração das atividades institucionais poderiam melhorar os resultados e incluir um número maior de docentes, discentes e beneficiados, os reclusos e educadores do Sistema Penitenciário. As ações são realizadas quinzenalmente na unidade prisional, envolvendo ampla participação da sociedade civil; os trabalhos são apresentados em forma de encontros de formação com os professores, palestras e debates com os detentos e atividades mediadas por elementos lúdicos: imagens, fotografias, filmes, documentários, músicas, poesias. Os estudantes das duas instituições se integram sem competição, os professores recebem formação continuada e as atividades lúdicas com os detentos quebram a rotina da prisão e estimulam os detentos a se manter nas salas de aula, reduzindo a evasão. A atividade é utilizada como carga horária de estágio para os alunos da ASCES e como atividades complementares para os estudantes de Pedagogia, e permitem às duas instituições contribuir para a melhoria da qualidade de ensino na prisão. Essa atividade também estimula o convívio de estudantes de instituições distintas, incluindo estudantes de instituições que, inclusive, não são parceiras dos projetos, atraindo a participação de muitos voluntários e ex-alunos da ASCES e da Faculdade de Filosofia, Ciências e Letras de Caruaru (FAFICA. A fraternidade política aparece como referencial teórico no trabalho com os docentes e no estímulo às relações entre os sujeitos envolvidos

  19. The Design of Medical Consumable Filing System Based on RFID Technology

    Institute of Scientific and Technical Information of China (English)

    WU Min; ZHONG Tian-ping; TANG Li-ming; QIN Xian; HUANG Ya-ping

    2015-01-01

    Objective: With the modern information technology, much management problems in the records of medical equipment and hospital supplies have been solved to achieve a comprehensive, real-time and accurate management. Methods: The import BARCODE file archiving system, in order to borrow and return series operation of the automatic identification, set the expiration of contracts, licenses and time of alarms. Results: The efficiency and accuracy of data entry, and mobile data collection terminal data processing in real time. Conclusion: Based on RFID technology for medical equipment supplies the file system to the radio channel as a transmission media, the target for non-contact automatic identification technology, medical equipment, supplies, intelligent file management and information technology.

  20. The Problems and Countermeasures of Open-shelf Book Borrowing Service in Colleges and Universities%高校图书馆开架借阅服务的问题及对策

    Institute of Scientific and Technical Information of China (English)

    郭小燕

    2012-01-01

    The open-shelf book borrowing service in the library has become the main way in service for readers. Carrying out open-shelf book borrowing system, not only is convenient for readers to use literature in the library, but also can improve the utilization rate of the literature. By analyzing the phenomenon in open-shelf book borrowing service, such as disorder of shelf, stain and loss of books, this paper has put forward the corresponding solutions.%开架借阅服务已成为图书馆为读者服务的主要方式.实行开架借阅,不仅方便读者利用馆藏文献,而且提高了馆藏文献的利用率.文章通过对开架借阅服务中出现的乱架、污损、丢失等现象的分析,提出了相应的解决办法.

  1. Influência da embalagem de atmosfera modificada e do tratamento com cálcio na cinética de degradação de ácido ascórbico e perda de massa em goiabas (Psidium guajava L.

    Directory of Open Access Journals (Sweden)

    YAMASHITA Fábio

    2000-01-01

    Full Text Available Goiabas de mesa (var. Pedro Sato no estádio verde maturo foram armazenadas a 8°C (85-95% UR por 49 dias. Uma parte das amostras foi tratada com solução de cloreto de cálcio 2% (p/v e o restante permaneceu sem tratamento. Posteriormente, foram embaladas individualmente em dois tipos de embalagem de atmosfera modificada (CryovacÒ PD-900 e CryovacÒ PD-961. Goiabas sem embalagem e não tratadas com cálcio, mantidas à mesma temperatura de 8°C serviram como controle. Foram realizadas análises de perda de massa, acidez titulável, teores de sólidos solúveis totais e ácido ascórbico. Os frutos embalados apresentaram taxas de perda de massa menores que os sem embalagem (p<0,05. Os frutos tratados com cálcio não apresentaram diferença na taxa de degradação de ácido ascórbico em relação aos não tratados e os frutos embalados com PD-900 apresentaram retenção de ácido ascórbico maior. Após 4 semanas, as goiabas sem embalagem apresentaram-se impróprias para consumo, devido ao murchamento e ataque de fungos, enquanto que as embaladas estavam em bom estado. Após a sexta semana, apenas os frutos embalados com PD-900 sem tratamento com cálcio estavam próprios para consumo. A embalagem de atmosfera modificada reduziu a perda de massa e ácido ascórbico e prolongou a vida-de-prateleira do produto. O emprego de cálcio não afetou as características analisadas.

  2. Globalization & technology

    DEFF Research Database (Denmark)

    Narula, Rajneesh

    Technology and globalization are interdependent processes. Globalization has a fundamental influence on the creation and diffusion of technology, which, in turn, affects the interdependence of firms and locations. This volume examines the international aspect of this interdependence at two levels...

  3. Living Technology

    DEFF Research Database (Denmark)

    2010-01-01

    This book is aimed at anyone who is interested in learning more about living technology, whether coming from business, the government, policy centers, academia, or anywhere else. Its purpose is to help people to learn what living technology is, what it might develop into, and how it might impact...... our lives. The phrase 'living technology' was coined to refer to technology that is alive as well as technology that is useful because it shares the fundamental properties of living systems. In particular, the invention of this phrase was called for to describe the trend of our technology becoming...... increasingly life-like or literally alive. Still, the phrase has different interpretations depending on how one views what life is. This book presents nineteen perspectives on living technology. Taken together, the interviews convey the collective wisdom on living technology's power and promise, as well as its...

  4. Living Technology

    DEFF Research Database (Denmark)

    2010-01-01

    This book is aimed at anyone who is interested in learning more about living technology, whether coming from business, the government, policy centers, academia, or anywhere else. Its purpose is to help people to learn what living technology is, what it might develop into, and how it might impact...... our lives. The phrase 'living technology' was coined to refer to technology that is alive as well as technology that is useful because it shares the fundamental properties of living systems. In particular, the invention of this phrase was called for to describe the trend of our technology becoming...... increasingly life-like or literally alive. Still, the phrase has different interpretations depending on how one views what life is. This book presents nineteen perspectives on living technology. Taken together, the interviews convey the collective wisdom on living technology's power and promise, as well as its...

  5. A Study of Loanwords in Chinese Borrowed From Japanese Based on the Memetic Theory%基于模因论的日语借词研究

    Institute of Scientific and Technical Information of China (English)

    李清萍

    2015-01-01

    As a new theory to explain cultural evolution based on Darwin's evolution theory, memetics provides a different perspective to explain language development rules. When studying the causes of existence as well as current development of loanwords in Chinese borrowed from Japanese, it can be found that memes with high transmitting ability in loanwords have been retained in Chinese. Meanwhile those memes failing to conform to Chinese cultural mentality as well as language habits tend to be eliminated due to their limited reduplication and transmission. Starting with memetics, this paper analyzes types and causes of loanwords memes in Chinese, then followed by further investigation on the popularity and disappearance of loanwords on the basis of the theory of strong and weak memes.%模因论是基于新达尔文进化论观点解释文化进化规律的新理论,为解释语言发展规律提供了新视角。从模因论点的角度探究汉语中日语借词的产生途径以及发展现状,可以发现:日语借词中传播能力强的模因在汉语中得以保留,不符合汉民族文化心理和汉语发展规律的日语借词模因,则由于复制和传播较少而在模因竞争中被淘汰。文章从模因论入手,分析了汉语中日语借词的模因形式及成因,并从强弱模因论的角度对日语借词的流行和消亡进行了探讨。

  6. Emerging Technologies

    OpenAIRE

    Salgar, S. M.

    2004-01-01

    Phenomenal advancements have taken place in the field of Information and communication technologies in the last decade. Spectacular and innovative changes are expected to take place in these fields in coming decade. Networking technologies are going through a sea change. This paper enumerates the likely networking technologies which are emerging, particularly WLANs. Most of the personal communication in the country will be through cellular/ mobile technologies, which are also covered in the p...

  7. Soulful Technologies

    DEFF Research Database (Denmark)

    Fausing, Bent

    2010-01-01

    or anthropomorphism is important for the branding of new technology. Technology is seen as creating a techno-transcendence towards a more qualified humanity which is in contact with fundamental human values like intuition, vision, and sensing; all the qualities that technology, industrialization, and rationalization...

  8. Technology Tiers

    DEFF Research Database (Denmark)

    Karlsson, Christer

    2015-01-01

    A technology tier is a level in a product system: final product, system, subsystem, component, or part. As a concept, it contrasts traditional “vertical” special technologies (for example, mechanics and electronics) and focuses “horizontal” feature technologies such as product characteristics...

  9. Technology Tiers

    DEFF Research Database (Denmark)

    Karlsson, Christer

    2015-01-01

    A technology tier is a level in a product system: final product, system, subsystem, component, or part. As a concept, it contrasts traditional “vertical” special technologies (for example, mechanics and electronics) and focuses “horizontal” feature technologies such as product characteristics...

  10. Assistive Technologies

    Science.gov (United States)

    Auat Cheein, Fernando A., Ed.

    2012-01-01

    This book offers the reader new achievements within the Assistive Technology field made by worldwide experts, covering aspects such as assistive technology focused on teaching and education, mobility, communication and social interactivity, among others. Each chapter included in this book covers one particular aspect of Assistive Technology that…

  11. Efeito do ácido ascórbico em massa de pão na presença do ácido tânico = Effect of ascorbic acid in bread dough in the presence of tannic acid

    Directory of Open Access Journals (Sweden)

    Ana Leticia Gomes Saraiva

    2010-07-01

    Full Text Available Pães de farinha de trigo com adição do agente oxidante ácido ascórbico foram elaborados, tentando-se encontrar a concentração de ácido tânico que melhor retivesse o ácido ascórbico, sem afetar significativamente as características reológicas e os principaisatributos sensoriais do pão. Os pães foram elaborados com a formulação de pão-padrão. Na primeira etapa, determinou-se a concentração de ácido ascórbico que melhor proporcionasse estabilidade à massa de pão-padrão (300 ppm. Na etapa seguinte, foramutilizadas na formulação da massa-padrão três concentrações diferentes de ácido tânico: 0,10; 0,20 e 0,30%, com a finalidade de se verificar a concentração que melhor retivesse o ácido ascórbico. Os pães foram elaborados com a formulação-padrão. Após o resfriamentodos pães, foi avaliada a retenção de ácido ascórbico, presente no pão de acordo com a concentração previamente determinada. Os resultados indicaram que o pão elaborado com a massa de pão-padrão (300 ppm de ácido ascórbico apresentou concentração de ácido ascórbico de 41,50 mg 100 g-1 de pão.Wheat flour breads with the addition of oxidizing agent ascorbic acid were elaborated trying to find the concentrations of tannic acid that best retained the ascorbic acid without significantly affecting the rheologic characteristics and main sensorial attributes of bread. Inthe first stage, the concentration of ascorbic acid that best provided stability to the dough (300 ppm was determined. In the following stage, three different concentrations of tannic acid were used: 0.10, 0.20 and 0.30%, with the purpose of verifying the ascorbic acid retention in the dough. The breads were elaborated with the standard formulation. After the elaboration of the breads, the ascorbic acid retention was evaluated in the previously determined concentration. The results showed that the bread elaborated with standard dough (300 ppm of ascorbic acid, presented

  12. Sensemaking technologies

    DEFF Research Database (Denmark)

    Madsen, Charlotte Øland

    Research scope: The scope of the project is to study technological implementation processes by using Weick's sensemaking concept (Weick, 1995). The purpose of using a social constructivist approach to investigate technological implementation processes is to find out how new technologies transform......, Orlikowski 2000). Viewing the use of technology as a process of enactment opens up for investigating the social processes of interpreting new technology into the organisation (Orlikowski 2000). The scope of the PhD project will therefore be to gain a deeper understanding of how the enactment of new...... & Brass, 1990; Kling 1991; Orlikowski 2000). It also demonstrates that technology is a flexible variable adapted to the organisation's needs, culture, climate and management philosophy, thus leading to different uses and outcomes of the same technology in different organisations (Barley 1986; 1990...

  13. Appropriate Technology as Indian Technology.

    Science.gov (United States)

    Barry, Tom

    1979-01-01

    Describes the mounting enthusiasm of Indian communities for appropriate technology as an inexpensive means of providing much needed energy and job opportunities. Describes the development of several appropriate technology projects, and the goals and activities of groups involved in utilizing low scale solar technology for economic development on…

  14. Are Students Borrowing Too Much?

    Science.gov (United States)

    Keynes, John Mainyard

    1995-01-01

    Increasing student costs and shrinking financial aid are causing college students to take on higher debt levels. While the situation is still manageable, educational planners must address the problem by monitoring student debt, raise funds for endowed scholarships, stabilize expenditures, provide better financial counseling to students, encourage…

  15. Síndrome ascítica em frangos de corte: uma revisão sobre a fisiologia, avaliação e perspectivas Ascitic syndrome in broiler chickens: a review about physiology, evaluation and perspectives

    Directory of Open Access Journals (Sweden)

    Millor Fernandes do Rosário

    2004-12-01

    Full Text Available Os programas de melhoramento genético de frangos de corte que buscam máxima velocidade de ganho de peso, alta eficiência alimentar, alta viabilidade, maior rendimento de carcaça e menor deposição de gordura podem desencadear algumas síndromes fisiológicas, dentre as quais destacam-se o estresse calórico, a morte súbita e a ascite. A ascite se enquadra no conceito das síndromes multifatoriais, uma vez que sua manifestação ocorre quando certos fatores genéticos e ambientais atuam em conjunto determinando o processo. As limitações anatômica e fisiológica da circulação sanguínea nos pulmões provocam a síndrome de hipertensão pulmonar (PHS; esta pode provocar grande acúmulo de fluido na cavidade abdominal, quadro este denominado de ascite. Ocorre redução da eficiência da circulação sangüínea, levando as aves à morte por hipóxia, predominantemente no período entre 30 e 40 dias de idade. Uma vez desencadeado o processo ascítico, a ave dificilmente é aproveitada no abate já que a mesma restringe o consumo de alimento, ganhando menos peso. Adicionalmente, a carcaça apresenta aumento do volume da cavidade abdominal e conseqüente congestão dos órgãos internos. A descrição da fisiologia, medidas de avaliação e perspectivas são apresentadas neste trabalho.Poultry genetic breeding programs which look for maximum weight gain, improved feed conversion, high viability, high carcass yield and low fat deposition may cause some physiologic syndromes, for example caloric stress, sudden death and ascites. Ascites is framed in concept of the multifactorial syndromes, once its manifestation happens when certain genetic and environment factors act together, determining the process. Anatomical and physiological limitations in blood circulation in the lungs give rise to pulmonary hypertension syndrome (PHS, producing great fluid accumulation in abdominal cavity, which is denominated ascites. Ascites causes reduction of blood

  16. Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes.

    Science.gov (United States)

    Knaus, Tanja; Mutti, Francesco G; Humphreys, Luke D; Turner, Nicholas J; Scrutton, Nigel S

    2015-01-07

    Ene-reductases (ERs) are flavin dependent enzymes that catalyze the asymmetric reduction of activated carbon-carbon double bonds. In particular, α,β-unsaturated carbonyl compounds (e.g. enals and enones) as well as nitroalkenes are rapidly reduced. Conversely, α,β-unsaturated esters are poorly accepted substrates whereas free carboxylic acids are not converted at all. The only exceptions are α,β-unsaturated diacids, diesters as well as esters bearing an electron-withdrawing group in α- or β-position. Here, we present an alternative approach that has a general applicability for directly obtaining diverse chiral α-substituted carboxylic acids. This approach combines two enzyme classes, namely ERs and aldehyde dehydrogenases (Ald-DHs), in a concurrent reductive-oxidative biocatalytic cascade. This strategy has several advantages as the starting material is an α-substituted α,β-unsaturated aldehyde, a class of compounds extremely reactive for the reduction of the alkene moiety. Furthermore no external hydride source from a sacrificial substrate (e.g. glucose, formate) is required since the hydride for the first reductive step is liberated in the second oxidative step. Such a process is defined as a hydrogen-borrowing cascade. This methodology has wide applicability as it was successfully applied to the synthesis of chiral substituted hydrocinnamic acids, aliphatic acids, heterocycles and even acetylated amino acids with elevated yield, chemo- and stereo-selectivity. A systematic methodology for optimizing the hydrogen-borrowing two-enzyme synthesis of α-chiral substituted carboxylic acids was developed. This systematic methodology has general applicability for the development of diverse hydrogen-borrowing processes that possess the highest atom efficiency and the lowest environmental impact.

  17. Sensemaking technologies

    DEFF Research Database (Denmark)

    Madsen, Charlotte Øland

    & Brass, 1990; Kling 1991; Orlikowski 2000). It also demonstrates that technology is a flexible variable adapted to the organisation's needs, culture, climate and management philosophy, thus leading to different uses and outcomes of the same technology in different organisations (Barley 1986; 1990......, Orlikowski 2000). Viewing the use of technology as a process of enactment opens up for investigating the social processes of interpreting new technology into the organisation (Orlikowski 2000). The scope of the PhD project will therefore be to gain a deeper understanding of how the enactment of new...

  18. Chemistry Technology

    Data.gov (United States)

    Federal Laboratory Consortium — Chemistry technology experts at NCATS engage in a variety of innovative translational research activities, including:Design of bioactive small molecules.Development...

  19. Efeito de diferentes processamentos sobre o teor de ácido ascórbico em suco de laranja utilizado na elaboração de bolo, pudim e geléia Effect of different processing methods on ascorbic acid content in orange juice used to make cakes, puddings and jelly

    Directory of Open Access Journals (Sweden)

    Patricia Teixeira da Silva

    2006-09-01

    Full Text Available Este estudo teve por objetivo avaliar a estabilidade do ácido ascórbico em suco de laranja cv. "Pêra" utilizado como ingrediente na elaboração de bolos, pudins e geléia. Os bolos e os pudins foram assados em forno convencional e de microondas, e a geléia foi elaborada em tacho aberto. Estas preparações foram submetidas a análises para determinação dos teores de ácido ascórbico e de sólidos solúveis totais, da acidez total titulável e do pH. Os teores de ácido ascórbico em bolos e pudins, quando comparados ao do suco de laranja in natura apresentaram redução de, respectivamente, 76,09% e 41,76%, quando assados em forno de microondas, e de 84,21% e 46,71%, quando assados em forno convencional. A geléia de laranja apresentou redução de 24,86% no teor de ácido ascórbico em relação ao suco de laranja in natura. A cocção de bolos e pudins realizada em forno de microondas proporcionou maior retenção do ácido ascórbico, quando comparada àquela realizada em forno convencional. Estas preparações apresentaram perda superior à da geléia, elaborada em tacho aberto. Foi observado, também, que os bolos perderam mais ácido ascórbico do que os pudins, em ambos os métodos de cocção avaliados.The aim of this study is to analyze the stability of ascorbic acid in orange juice cv. "Pera" used as an ingredient to prepare cakes, puddings and jelly. Cakes and puddings were baked in conventional and microwave ovens and the jelly was prepared in a pan without a lid. Ascorbic acid content, total soluble solids, total tritatable acidity and the pH were determined in all prepared foods. The AA content in cakes and puddings, when compared to the content of orange juice in natura had a reduction of 76.09% and 41.76%, respectively when baked in a microwave oven and of 84.21% and 46.71%, when baked in a conventional oven. Orange jelly showed a reduction of 24.76% in the ascorbic acid content related to orange juice in natura

  20. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-05-01

    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.