WorldWideScience

Sample records for technologies 3rd edition

  1. Introducing ZBrush 3rd Edition

    CERN Document Server

    Keller, Eric

    2012-01-01

    Learn ZBrush inside and out with this updated new edition Get totally comfortable sculpting in a digital environment with the latest edition of this bestselling beginner's guide to ZBrush. Fully updated for the newest version of the software, ZBrush 4R3, this book dispels any fears you might have about the difficulty of using ZBrush and soon has you creating realistic, cartoon, and organic models with flair. Learn all the essentials, as you complete fun tutorials on painting, meshes, organic scripting, hard surface sculpting, lighting, rendering, and more. Introduces you to ZBrush, the sculpt

  2. Veterinary Microbiology, 3rd Edition

    Science.gov (United States)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  3. Building java programs (3rd edition)

    CERN Document Server

    Reges, Stuart

    2013-01-01

    Building Java Programs: A Back to Basics Approach, Third Edition, introduces novice programmers to basic constructs and common pitfalls by emphasizing the essentials of procedural programming, problem solving, and algorithmic reasoning. By using objects early to solve interesting problems and defining objects later in the course, Building Java Programs develops programming knowledge for a broad audience. NEW! This edition is available with MyProgrammingLab, an innovative online homework and assessment tool. Through the power of practice and immediate personalized feedback, MyProgrammingLab helps students fully grasp the logic, semantics, and syntax of programming. Note: If you are purchasing the standalone text or electronic version, MyProgrammingLab does not come automatically packaged with the text. To purchase MyProgrammingLab, please visit: myprogramminglab.com or you can purchase a package of the physical text + MyProgrammingLab by searching the Pearson Higher Education web site. MyProgrammi...

  4. Alaska Highway bibliography, 3rd edition

    DEFF Research Database (Denmark)

    Prange, Laurie

    . The military need for the Alaska Highway and Canol pipeline declined at the end of World War II. In 1946, Canada officially accepted responsibility for maintaining and developing the Yukon portion of the Alaska Highway. The Alaska Highway affected both First Nations and non-First Nations peoples immediately...... the 1920s and 1930s a small but vocal group of “builders” began to campaign for a highway, either a coastal or inland route, to improve the northwest’s economic base. With the impending threat of war in the late 1930s, there was an increasing awareness by the American and Canadian governments....... The impacts included an increased awareness of the world outside of the Yukon, imported ideas and technology, improved health care, highway transportation, telecommunications, and the development of more mining and tourist-related industries....

  5. Alaska Highway bibliography, 3rd edition

    DEFF Research Database (Denmark)

    Prange, Laurie

    Since the early 20th century various schemes were considered for the construction of roads, trails or railways 71 to link the Yukon, northern British Columbia and Alaska to the “outside.” These schemes were motivated by economic interests, including mining, lumber and tourism concerns. During the....... The impacts included an increased awareness of the world outside of the Yukon, imported ideas and technology, improved health care, highway transportation, telecommunications, and the development of more mining and tourist-related industries....... land route to Alaska for defence purposes. The military was not interested in developing or planning a highway for the civilian needs of the future. The chosen route ran from Edmonton to Whitehorse, then on to Fairbanks. The U.S. Army and U.S. Public Roads Administration (PRA) roughed out a “pioneer...

  6. TIES for Dummies 3rd Edition (Technology Identification, Evaluation, and Selection) Basic how to's to implement the TIES method

    Science.gov (United States)

    Kirby, Michelle R.

    2002-01-01

    The TIES method is a forecasting environment whereby the decision-maker has the ability to easily assess and trade-off the impact of various technologies without sophisticated and time-consuming mathematical formulations. TIES provides a methodical approach where technically feasible alternatives can be identified with accuracy and speed to reduce design cycle time, and subsequently, life cycle costs, and was achieved through the use of various probabilistic methods, such as Response Surface Methodology and Monte Carlo Simulations. Furthermore, structured and systematic techniques are utilized from other fields to identify possible concepts and evaluation criteria by which comparisons can be made. This objective is achieved by employing the use of Morphological Matrices and Multi-Attribute Decision Making techniques. Through the execution of each step, a family of design alternatives for a given set of customer requirements can be identified and assessed subjectively or objectively. This methodology allows for more information (knowledge) to be brought into the earlier phases of the design process and will have direct implications on the affordability of the system. The increased knowledge allows for optimum allocation of company resources and quantitative justification for program decisions. Finally, the TIES method provided novel results and quantitative justification to facilitate decision making in the early stages of design so as to produce affordable and quality products.

  7. 3rd International Conference on Multimedia Technology

    CERN Document Server

    Yang, Jian; Jiao, Feng

    2014-01-01

    Proceedings of the 3rd International Conference on Multimedia Technology (ICMT2013) focuses on both the theory and applications of multimedia technology. The recent advances, new research findings and applications in the fields of theoretical, experimental and applied image & video processing and multimedia technology presented at the conference are brought together in this book. It will serve as a valuable reference for scientists and engineers working in multimedia and related fields. Prof. Aly A. Farag works at the University of Louisville, USA; Prof. Jian Yang works at Tsinghua University, China; Dr. Feng Jiao works at Nanjing University of Information Science & Technology, China.

  8. 3rd International Conference on Robot Intelligence Technology and Applications

    CERN Document Server

    Yang, Weimin; Jo, Jun; Sincak, Peter; Myung, Hyun

    2015-01-01

    This book covers all aspects of robot intelligence from perception at sensor level and reasoning at cognitive level to behavior planning at execution level for each low level segment of the machine. It also presents the technologies for cognitive reasoning, social interaction with humans, behavior generation, ability to cooperate with other robots, ambience awareness, and an artificial genome that can be passed on to other robots. These technologies are to materialize cognitive intelligence, social intelligence, behavioral intelligence, collective intelligence, ambient intelligence and genetic intelligence. The book aims at serving researchers and practitioners with a timely dissemination of the recent progress on robot intelligence technology and its applications, based on a collection of papers presented at the 3rd International Conference on Robot Intelligence Technology and Applications (RiTA), held in Beijing, China, November 6 - 8, 2014. For better readability, this edition has the total 74 papers group...

  9. Radar principles for the nonspecialist, 3rd edition

    CERN Document Server

    Toomay, John

    2004-01-01

    Radar Principles for the Non-specialist, Third Edition continues its popular tradition: to distill the very complex technology of radar into its fundamentals, tying them to the laws of nature on one end and to the most modern and complex systems on the other. It starts with electromagnetic propagation, describes a radar of the utmost simplicity, and derives the radar range equation from that simple radar. Once the range equation is available, the book attacks the meaning of each term in it, moving through antennas, detection and tracking, radar cross-section, waveforms andsignal proces

  10. Explanatory Supplement to the Astronomical Almanac (3rd Edition)

    Science.gov (United States)

    Urban, Sean E.; Seidelmann, P. K.

    2014-01-01

    Publications and software from the the Astronomical Applications Department of the US Naval Observatory (USNO) are used throughout the world, not only in the Department of Defense for safe navigation, but by many people including other navigators, astronomers, aerospace engineers, and geodesists. Products such as The Nautical Almanac, The Astronomical Almanac, and the Multiyear Interactive Computer Almanac (MICA) are regarded as international standards. To maintain credibility, it is imperative that the methodologies employed and the data used are well documented. "The Explanatory Supplement to the Astronomical Almanac" (hereafter, "The ES") is a major source of such documentation. It is a comprehensive reference book on positional astronomy, covering the theories and algorithms used to produce The Astronomical Almanac, an annual publication produced jointly by the Nautical Almanac Office of USNO and Her Majesty's Nautical Almanac Office (HMNAO). The first edition of The ES appeared in 1961, and the second followed in 1992. Several major changes have taken place in fundamental astronomy since the second edition was published. Advances in radio observations allowed the celestial reference frame to be tied to extragalactic radio sources, thus the International Celestial Reference System replaced the FK5 system. The success of ESA's Hipparcos satellite dramatically altered observational astrometry. Improvements in Earth orientation observations lead to new precession and nutation theories. Additionally, a new positional paradigm, no longer tied to the ecliptic and equinox, was accepted. Largely because of these changes, staff at USNO and HMNAO decided the time was right for the next edition of The ES. The third edition is now available; it is a complete revision of the 1992 book. Along with subjects covered in the previous two editions, the book also contains descriptions of the major advancements in positional astronomy over the last 20 years, some of which are

  11. Pediatric Dentistry: A Clinical Approach, 3rd Edition

    DEFF Research Database (Denmark)

    and updated new edition, with an increased focus on evidence based care •Includes three new chapters on genetics, child abuse and neglected children, and ethics •Pedodontic endodontics is now covered by two chapters – one on primary teeth and one on young permanent teeth •Features a companion website...

  12. Mathematics in Early Years Education. 3rd Edition

    Science.gov (United States)

    Montague-Smith, Ann; Price, Alison

    2012-01-01

    This third edition of the best-selling "Mathematics in Nursery Education" provides an accessible introduction to the teaching of mathematics in the early years. Covering all areas of mathematics learning--number and counting, calculation, pattern, shape, measures and data handling--it summarises the research findings and underlying key concepts…

  13. 3rd International Conference on Computer & Communication Technologies

    CERN Document Server

    Bhateja, Vikrant; Raju, K; Janakiramaiah, B

    2017-01-01

    The book is a compilation of high-quality scientific papers presented at the 3rd International Conference on Computer & Communication Technologies (IC3T 2016). The individual papers address cutting-edge technologies and applications of soft computing, artificial intelligence and communication. In addition, a variety of further topics are discussed, which include data mining, machine intelligence, fuzzy computing, sensor networks, signal and image processing, human-computer interaction, web intelligence, etc. As such, it offers readers a valuable and unique resource.

  14. Semiconductor Material and Device Characterization, 3rd Edition

    Science.gov (United States)

    Schroder, Dieter K.

    2005-12-01

    Semiconductor Material and Device Characterizationis the only book on the market devoted to the characterization techniques used by the modern semiconductor industry to measure diverse semiconductor materials and devices. It covers the full range of electrical and optical characterization methods while thoroughly treating the more specialized chemical and physical techniques. In the third edition, Professor Schroder has rewritten parts of each chapter and added two new chapters (Charge Based Measurements and Failure Analysis and Reliability), redrawn and updated most figures, and included new problems and approximately 100 new references. * New end of chapter problems * Outdated figures have been redone and replaced with current data * Up-to-date bibliography with over 1400 references * Professor Schroder is recognized as the authority in the field of semiconductor characterization

  15. 3rd International Conference on Intelligent Technologies and Engineering Systems

    CERN Document Server

    2016-01-01

    This book includes the original, peer reviewed research from the 3rd International Conference on Intelligent Technologies and Engineering Systems (ICITES2014), held in December, 2014 at Cheng Shiu University in Kaohsiung, Taiwan. Topics covered include: Automation and robotics, fiber optics and laser technologies, network and communication systems, micro and nano technologies, and solar and power systems. This book also Explores emerging technologies and their application in a broad range of engineering disciplines Examines fiber optics and laser technologies Covers biomedical, electrical, industrial, and mechanical systems Discusses multimedia systems and applications, computer vision and image & video signal processing.

  16. The Handbook of Research Impact Assessment. 3rd Edition - Revised

    Science.gov (United States)

    1995-02-01

    34 DIABETOLOGIA 1994, Vol 37, Iss SI, pp A176-A176 Hartz-AJ Gottlieb-MS Kuhn -EM Rimm-AA, "The Relationship Between Adjusted Hospital Mortality and the...Results of Peer-Review," HEALTH SERVICES RESEARCH 1993, Vol 27, Iss 6, pp 765-777 Hartz-AJ Kuhn -EM Kayser-KL Pryor-DP Green-R Rimm-AA, "Assessing...211-219 Latour -B, "The Impact of Science Studies on Political-Philosophy," SCIENCE TECHNOLOGY & HUMAN VALUES 1991, Vol 16, Iss 1, pp 3-19 Lauer-G

  17. Iowa Acceleration Scale Manual: A Guide for Whole-Grade Acceleration K-8. (3rd Edition, Manual)

    Science.gov (United States)

    Assouline, Susan G.; Colangelo, Nicholas; Lupkowski-Shoplik, Ann; Forstadt, Leslie; Lipscomb, Jonathon

    2009-01-01

    Feedback from years of nationwide use has resulted in a 3rd Edition of this unique, systematic, and objective guide to considering and implementing academic acceleration. Developed and tested by the Belin-Blank Center at the University of Iowa, the IAS ensures that acceleration decisions are systematic, thoughtful, well reasoned, and defensible.…

  18. Specifications and Construction Methods for Asphalt Concrete and Other Plant-Mix Types, 3rd Edition.

    Science.gov (United States)

    Asphalt Inst., College Park, MD.

    The purpose of this publication is to assist engineers in the analysis, design and control of paving projects that use asphalt concrete and other asphalt plant-mixes. The scope of this new third edition has been enlarged, and changes necessitated by advances in asphalt technology have been incorporated. Chapters I and II and Appendices A and B…

  19. 3rd International Conference on Photonics, Optics and Laser Technology

    CERN Document Server

    Raposo, Maria

    2016-01-01

    The book provides a collection of selected papers presented to the third International Conference on Photonics, Optics and Laser Technology PHOTOPTICS 2015, covering the three main conference scientific areas of “Optics”, “Photonics” and “Lasers”. The selected papers, in two classes full and short, result from a double blind review carried out by the conference program committee members which are highly qualified experts in conference topic areas.

  20. A procedure for safety assessment of components with cracks - Handbook. 3rd revised edition

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, P.; Bergman, M.; Brickstad, B.; Dahlberg, L.; Nilsson, F.; Sattari-Far, I. [SAQ Kontroll AB, Stockholm (Sweden)

    1999-12-01

    given objectives, the handbook contains solutions for the stress intensity factor and the limit load for a number of crack geometries of importance for applications. It also contains rules for defect characterization, recommendations for estimation of residual stresses, material data for nuclear applications and a safety evaluation system. To ensure conservatism, the procedure with the given solutions of the stress intensity factor and the limit load has been validated. Predictions of the procedure were compared with the actual outcome of full scale experiments reported in the literature. The first edition of the handbook was released in 1990 and the second in 1991. This third edition has been extensively revised. A new safety evaluation system has been introduced. The conservatism in the method for assessment of secondary stresses has been reduced. The solutions for the stress intensity factor and the limit load, the recommendations for estimation of residual stresses and the given material data for nuclear applications have been updated. A modern Windows based PC-program SACC has been developed which can perform the assessments described in this handbook including calculation of crack growth due to stress corrosion and fatigue. The program also has an option which enables assessment of cracks according to the 1995 edition of the ASME Boiler and Pressure Vessel Code, Section XI. Appendices A, C and H for assessment of cracks in ferritic pressure vessels, austenitic piping and ferritic piping, respectively.

  1. Psychometric properties and validation of Portuguese version of Ages & Stages Questionnaires (3rd edition): 9, 18 and 30 Questionnaires.

    Science.gov (United States)

    Lopes, Sónia; Graça, Patrícia; Teixeira, Salete; Serrano, Ana Maria; Squires, Jane

    2015-09-01

    The essential underlying foundations of Early Intervention (EI), in which parents/family play a critical role in their child's development, leads us to conclude that their contribution assessing early detection of problems is fundamental. The Ages & Stages Questionnaires (ASQ) is a standardized screening instrument that has been successfully studied in different countries and cultures. Translate and study the psychometrics proprieties of the Portuguese version of the 9, 18 and 30month questionnaires of the Ages and Stages Questionnaires, 3rd edition (ASQ-3). Cross-sectional study. Validity and reliability were studied in a sample of 234 parents of children within 9, 18 and 30months. The results indicated that the questionnaires had good internal consistency, strong agreement between observers and between observations with two weeks interval, and strong Pearson product-moment correlation coefficients between the overall and the total for each domain. The cutoff points (i.e. 2 standard deviations below the mean domain score), that identifies children who should receive further referral for more comprehensive assessment, were close to those determined in the original ASQ-3 psychometric studies. Cronbach's alpha ranging from .42 to .70 and Pearson's r values varies from .22 to .60. Although some weaknesses were noted in psychometric qualities analysis, it can be concluded that the ASQ-PT of 9, 18 and 30months of age fulfills the requirements of a screening tool validated for the Portuguese population. To allow the early identification of children with developmental problems. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications

    CERN Document Server

    Koziel, Slawomir; Kacprzyk, Janusz; Leifsson, Leifur; Ören, Tuncer

    2015-01-01

    This book includes extended and revised versions of a set of selected papers from the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2013) which was co-organized by the Reykjavik University (RU) and sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC). SIMULTECH 2013 was held in cooperation with the ACM SIGSIM - Special Interest Group (SIG) on SImulation and Modeling (SIM), Movimento Italiano Modellazione e Simulazione (MIMOS) and AIS Special Interest Group on Modeling and Simulation (AIS SIGMAS) and technically co-sponsored by the Society for Modeling & Simulation International (SCS), Liophant Simulation, Simulation Team and International Federation for Information Processing (IFIP). This proceedings brings together researchers, engineers, applied mathematicians and practitioners working in the advances and applications in the field of system simulation.

  3. Methodology Guidelines on Life Cycle Assessment of Photovoltaic Electricity: 3rd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Frischknecht, Rolf; Heath, Garvin; Raugei, Marco; Sinha, Parikhit; de Wild-Scholten, Mariska

    2016-01-01

    Life Cycle Assessment (LCA) is a structured, comprehensive method of quantifying material- and energy-flows and their associated emissions caused in the life cycle of goods and services. The ISO 14040 and 14044 standards provide the framework for LCA. However, this framework leaves the individual practitioner with a range of choices that can affect the results and thus the conclusions of an LCA study. The current IEA guidelines were developed to provide guidance on assuring consistency, balance, and quality to enhance the credibility and reliability of the results from LCAs on photovoltaic (PV) electricity generation systems. The guidelines represent a consensus among the authors - PV LCA experts in North America, Europe, and Asia - for assumptions made on PV performance, decisions on process input and emissions allocation, methods of analysis, and reporting of the results. Guidance is given on PV-specific parameters used as inputs in LCA and on choices and assumptions in life cycle inventory (LCI) data analysis and on implementation of modeling approaches. A consistent approach towards system modeling, the functional unit, the system boundaries, water use modeling and the allocation aspects enhances the credibility of PV electricity LCA studies and enables balanced LCA-based comparisons of different electricity producing technologies. The document discusses metrics like greenhouse gas emissions (GHG), cumulative energy demand (CED), acidification potential (AP), ozone depletion potential (ODP), human toxicity, ecotoxicity and ionizing radiation. Guidance is given for the definition of the energy payback time (EPBT), the nonrenewable energy payback time (NREPBT), and the impact mitigation potentials (IMP). The indicator energy return on investment (EROI) is described in a separate International Energy Agency (IEA) PV Power Systems (PVPS) Task 12 report (Raugei et al. 2015). The guidelines on the reporting and communication of the results serve the need for

  4. ic-cmtp3: 3rd International Conference on Competitive Materials and Technology Processes

    Science.gov (United States)

    2016-04-01

    Competitiveness is one of the most important factors in our lives and it plays a key role in the efficiency both of organizations and societies. The more scientifically advanced and prepared organizations develop more competitive materials with better physical, chemical, and biological properties, and the leading companies apply more competitive equipment and technological processes. The aims of the 3rd International Conference on Competitive Materials and Technology Processes (ic-cmtp3), and the 1st International Symposium on Innovative Carbons and Carbon Based Materials (is-icbm1) and the 1st International Symposium on Innovative Construction Materials (is-icm1) organized alongside are the following: —Promote new methods and results of scientific research in the fields of material, biological, environmental and technological sciences; —Exchange information between the theoretical and applied sciences as well as technical and technological implementations; —Promote communication and collaboration between the scientists, researchers and engineers of different nations, countries and continents. Among the major fields of interest are advanced and innovative materials with competitive characteristics, including mechanical, physical, chemical, biological, medical and thermal, properties and extreme dynamic strength. Their crystalline, nano - and micro-structures, phase transformations as well as details of their technological processes, tests and measurements are also in the focus of the ic-cmtp3 conference and the is-scbm1 and is-icm1 symposia. Multidisciplinary applications of material science and the technological problems encountered in sectors like ceramics, glasses, thin films, aerospace, automotive and marine industries, electronics, energy, construction materials, medicine, biosciences and environmental sciences are of particular interest. In accordance with the program of the ic-cmtp3 conference and is-icbm1 and is-icm1 symposia we have received more

  5. 3rd ACIS International Conference on Applied Computing and Information Technology

    CERN Document Server

    2016-01-01

    This edited book presents scientific results of the 3nd International Conference on Applied Computing and Information Technology (ACIT 2015) which was held on July 12-16, 2015 in Okayama, Japan. The aim of this conference was to bring together researchers and scientists, businessmen and entrepreneurs, teachers, engineers, computer users, and students to discuss the numerous fields of computer science and to share their experiences and exchange new ideas and information in a meaningful way. Research results about all aspects (theory, applications and tools) of computer and information science, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.

  6. PREFACE: 3rd Iberian Meeting on Aerosol Science and Technology (RICTA 2015)

    Science.gov (United States)

    Orza, J. A. G.; Costa, M. J.

    2015-12-01

    The Third Iberian Meeting on Aerosol Science and Technology (RICTA 2015) was held in the city of Elche (province of Alicante, Spain) from 29 June to 1 July 2015, at Centro de Congresos Ciutat d'Elx. This event was organized and hosted by the Statistical and Computational Physics Laboratory (SCOLAb) of Universidad Miguel Hernández under the auspices of AECyTA, the Spanish Association for Aerosol Science and Technology Research. As in previous editions, the participation of young researchers was especially welcome, with the organization of the VI Summer School on Aerosol Science and Technology and awards for the best poster and PhD thesis, in recognition of outstanding research or presentations focusing on aerosols, during the early stage of their scientific career. RICTA 2015 aims to present the latest research and advances on the field of aerosols, as well as fostering interaction among the Portuguese and Spanish communities. The meeting gathered over 70 participants from 7 different countries, covering a wide range of aerosol science and technology. It included invited lectures, keynote talks, and several specialized sessions on different issues related to atmospheric aerosols, radiation, instrumentation, fundamental aerosol science, bioaerosols and health effects. The editors would like to express their sincere gratitude to all the participants, in particular, those who contributed to this special issue by submitting their papers to convey the current science discussed at RICTA 2015. In this special issue a series of peer-reviewed papers that cover a wide range of topics are presented: aerosol formation, emission, as well as aerosol composition in terms of physical and optical properties, spatial/temporal distribution of aerosol parameters, aerosol modeling and atmospheric effects, as well as instrumentation devoted to aerosol measurements. Finally, we also thank the referees for their valuable revision of these papers.

  7. “Patenting Bioprinting Technologies in the US and Europe– The 5th element in the 3rd dimension"

    DEFF Research Database (Denmark)

    Minssen, Timo; Mimler, Marc

    2017-01-01

    of bioprinting- inventions are being patented or would be- protectable under European and US patent laws. Rather than focusing on the highly relevant questions that 3D printing poses for patent infringement doctrines and research exemptions , this paper concentrates on the question of patentable subject matter......, “Patenting Bioprinting Technologies in the US and Europe– The 5th element in the 3rd dimension", Working Paper, forthcoming in: RM Ballardini, M Norrgård & J Partanen (red), 3D printing, Intellectual Property and Innovation – Insights from Law and Technology. Wolters Klu. Available at https...

  8. “Patenting Bioprinting Technologies in the US and Europe– The 5th element in the 3rd dimension"

    DEFF Research Database (Denmark)

    Minssen, Timo; Mimler, Marc

    2017-01-01

    of bioprinting- inventions are being patented or would be- protectable under European and US patent laws. Rather than focusing on the highly relevant questions that 3D printing poses for patent infringement doctrines and research exemptions , this paper concentrates on the question of patentable subject matter......, “Patenting Bioprinting Technologies in the US and Europe– The 5th element in the 3rd dimension", Working Paper, forthcoming in: RM Ballardini, M Norrgård & J Partanen (red), 3D printing, Intellectual Property and Innovation – Insights from Law and Technology. Wolters Klu. Available at SSRN: https://ssrn.com/abstract=...

  9. 《牛津高阶英汉双解词典》第3版与第4版编纂的比较研究%The Differences between the 3rd Edition and the 4th Edition of Oxford Advanced Learner's English-Chinese Dictionary in Compilation

    Institute of Scientific and Technical Information of China (English)

    秦勇

    2003-01-01

    This paper is to analyze the differences between the 3rd edition and 4th edition of Oxford Advanced Learner's English- Chinese Dictionary (hereafter referred to as ALECD3 and ALECD4). By making comparison between the two dictionaries in the learner's and compiler's perspectives, it highlights the priority of the 4th edition in content and compilation. Following a brief introduction in Part 1,Part 2 examines the innovations the 3rd edition has made in verb - pattern scheme, compounds, entries,examples,adjectives and appendices from the learner's perspective. Part3 holds a theoretical discussion of prescription and description in the 4th edition.

  10. Metabolic engineering of E.coli for the production of a precursor to artemisinin, an anti-malarial drug [Chapter 25 in Manual of Industrial Microbiology and Biotechnology, 3rd edition

    Energy Technology Data Exchange (ETDEWEB)

    Petzold, Christopher; Keasling, Jay

    2011-07-18

    This document is Chapter 25 in the Manual of Industrial Microbiology and Biotechnology, 3rd edition. Topics covered include: Incorporation of Amorpha-4,11-Diene Biosynthetic Pathway into E. coli; Amorpha-4,11-Diene Pathway Optimization; "-Omics" Analyses for Increased Amorpha-4,11-Diene Production; Biosynthetic Oxidation of Amorpha-4,11-Diene.

  11. Implications of Technology for Teaching and Learning. Annual Professional Education Seminar of Central States Colleges and Universities (3rd, November, 1967).

    Science.gov (United States)

    Woodruff, Asahel; Froyen, Len

    This report of the proceedings of the 3rd Annual Professional Education Seminar of the Central States Colleges and Universities centers upon the implications of technology for teaching and learning and contains addresses delivered, including "Some Concerns Related to Technology in Education," by Len Froyen; and "Implications of Technology for…

  12. Grand challenges in technology enhanced learning outcomes of the 3rd Alpine Rendez-Vous

    CERN Document Server

    Fischer, Frank; Sutherland, Rosamund; Zirn, Lena

    2014-01-01

    This book presents a key piece of the vision and strategy developed in STELLAR. It sets out a new mid-term agenda by defining Grand Challenges for research and development in technology-enhanced learning. Other than mere technology prizes, STELLAR Grand Challenges deal with problems at the interface of social and technical sciences. They pose problems that can be solved only in interdisciplinary collaboration. The descriptions of the Grand Challenge Problems were sent out to a number of stakeholders from industry, academia, and policy-making who responded with insightful, creative and critical comments bringing in their specific perspectives. This book will inspire everyone interested in TEL and its neighboring disciplines in their future projects. All of the listed problems, first hints with respect to the approach, measurable success indicators and funding sources are outlined. The challenges focus on what noted experts regard as important upcoming, pending, and innovative fields of research, the solution o...

  13. 走向学习、认知与技术研究的深度融合——《教育传播与技术研究手册(第三版)》第三部分述评%Toward Further Integration of Research on Learning,Cognition and Technology:A Review on Part Ⅲ ofSummary and Comment on Part Ⅲ of Handbook of Research on Educational Communication and Technology(3rd edition)

    Institute of Scientific and Technical Information of China (English)

    赵健

    2010-01-01

    对J.Michael Spector,M.David Merrill,Jeroen Van Merrienboer and Marcy P.Driscoll主编的Handbook of Research on Educational Communications and Technology(3rd Ed.)[,Lawrence Erlbaum 2008年出版]第三部分"技术"专题的述评,共分四个部分:第一部分是对16章内容的简要介绍,在介绍中兼顾了不同技术的发展脉络,从中探知不同技术的发展、研究状况与前景;第二部分在对比该手册第二版"技术"部分的基础上,概括了技术研究主题的延续与变化;第三部分从"硬技术"、"软技术"到"设计技术"的发展视角,评述教育技术的发展轨迹;第四部分评述了当代教育技术发展的重要特征是学习、认知和技术以学习者为中心的进一步融合.

  14. Selected Abstracts of the 3rd Edition of Transport of High Risk Infants; Oxford (UK; August 31st-September 2nd, 2017

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-08-01

    Full Text Available Selected Abstracts of the 3rd Edition of Transport of High Risk Infants; Oxford (UK; August 31st-September 2nd, 2017ABS 1. MORTALITY RATE IN 23-30 WEEKS PRE­MATURE BORN IN LEVEL 2 HOSPITAL IN COMPARISON TO THOSE BORN IN TERTIARY-CARE HOSPITAL • J.P. Doray, J.L. DorayABS 2. THE QUEBEC AEROMEDICAL EXPERIENCE: EVACUATION OF NEONATES FROM AREAS IN EXTREME WEATHER CONDITIONS – IN­NOVATIONS IN SAFETY AND EFFICIENCY • É. Notebaert, J. Provencher, R. Bernier, S. Côté, S. KindABS 3. NASAL HIGH FLOW SUPPORT DURING NEONATAL RETRIEVAL IN VICTORIA, AUSTRALIA • V. Abraham, C. Roberts, B. Manley, L. Owen, M. Stewart, P. DavisABS 4. NEONATAL TRANSPORT TO AND FROM A REGIONAL LEVEL 2 CENTRE • C. Moore, M. Cassidy, M. Byrne, A. Bowden, J. Franta, I. Farombi, J. FitzsimonsABS 5. PASSIVE THERAPEUTIC HYPOTHERMIA DURING AMBULANCE AND HELICOPTER SECONDARY NEONATAL TRANSPORT IN NEONATES WITH HYPOXIC BRAIN INJURY: 10-YEARS RETROSPECTIVE SURVEY • M. Leben, M. Nolimal, I. Vidmar, S. GrosekABS 6. STABILIZATION OF CRITICALLY ILL NEW­BORNS: PREVENTION OF ACUTE KIDNEY INJURY • A. Babintseva, Y. Hodovanets, L. AgafonovaABS 7. TRANSPORT OF THE SURGICAL NEONATES • R. Pejaver, A. Poveidein, D. Winterbank-Scott, C. Keys, N. GuptaABS 8. AUDIT OF VENTILATED NEONATAL TRANS­FERS IN NORTHERN IRELAND FROM 1ST JANUARY 2017 UNTIL 1ST MAY 2017 • R. Moore, S. KnoxABS 9. “HUB AND SPOKE” ECMO IN NEONATES WITH MECONIUM ASPIRATION SYNDROME: A PRELIMINARY REPORT • N. Doglioni, D. Fichera, F. Zanella, M. Padalino, V. Vida, G. Stellin, P. Lago, D. TrevisanutoABS 10. INTRA-HOSPITAL TRANSPORTATION OF EX­TREMELY PRETERM INFANTS AND INCI­DENCE OF INTRAVENTRICULAR HAEMOR­RHAGES • N. Wadström, M. Breindahl, B. Hallberg, B. SkiöldABS 11. RISK OF POSTNATAL TRANSPORT AND OUT­COME OF LATE PRETERM INFANTS BORN AT NON-TERTIARY CENTRES: A RETRO­SPEC­TIVE COHORT STUDY • N. Doglioni, L. Salmaso, P. Facchin, D. TrevisanutoABS 12. COMPARING THREE METHODS OF THERA

  15. Delivery technologies for genome editing.

    Science.gov (United States)

    Yin, Hao; Kauffman, Kevin J; Anderson, Daniel G

    2017-03-24

    With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials.

  16. Technology Catalogue. First edition

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    The Department of Energy`s Office of Environmental Restoration and Waste Management (EM) is responsible for remediating its contaminated sites and managing its waste inventory in a safe and efficient manner. EM`s Office of Technology Development (OTD) supports applied research and demonstration efforts to develop and transfer innovative, cost-effective technologies to its site clean-up and waste management programs within EM`s Office of Environmental Restoration and Office of Waste Management. The purpose of the Technology Catalogue is to provide performance data on OTD-developed technologies to scientists and engineers assessing and recommending technical solutions within the Department`s clean-up and waste management programs, as well as to industry, other federal and state agencies, and the academic community. OTD`s applied research and demonstration activities are conducted in programs referred to as Integrated Demonstrations (IDs) and Integrated Programs (IPs). The IDs test and evaluate.systems, consisting of coupled technologies, at specific sites to address generic problems, such as the sensing, treatment, and disposal of buried waste containers. The IPs support applied research activities in specific applications areas, such as in situ remediation, efficient separations processes, and site characterization. The Technology Catalogue is a means for communicating the status. of the development of these innovative technologies. The FY93 Technology Catalogue features technologies successfully demonstrated in the field through IDs and sufficiently mature to be used in the near-term. Technologies from the following IDs are featured in the FY93 Technology Catalogue: Buried Waste ID (Idaho National Engineering Laboratory, Idaho); Mixed Waste Landfill ID (Sandia National Laboratories, New Mexico); Underground Storage Tank ID (Hanford, Washington); Volatile organic compound (VOC) Arid ID (Richland, Washington); and VOC Non-Arid ID (Savannah River Site, South Carolina).

  17. Technology catalogue. Second edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    The Department of Energy`s (DOE`s) Office of Environmental Management (EM) is responsible for remediating DOE contaminated sites and managing the DOE waste inventory in a safe and efficient manner. EM`s Office of Technology Development (OTD) supports applied research and demonstration efforts to develop and transfer innovative, cost-effective technologies to its site clean-up and waste-management programs within EM. The purpose of the Technology Catalogue is to: (a) provide performance data on OTD-developed technologies to scientists and engineers responsible for preparing Remedial Investigation/Feasibility Studies (RI/FSs) and other compliance documents for the DOE`s clean-up and waste-management programs; and (b) identify partnering and commercialization opportunities with industry, other federal and state agencies, and the academic community.

  18. 3rd annual biomass energy systems conference

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The main objectives of the 3rd Annual Biomass Energy Systems Conference were (1) to review the latest research findings in the clean fuels from biomass field, (2) to summarize the present engineering and economic status of Biomass Energy Systems, (3) to encourage interaction and information exchange among people working or interested in the field, and (4) to identify and discuss existing problems relating to ongoing research and explore opportunities for future research. Abstracts for each paper presented were edited separately. (DC)

  19. Hydrogen utilization international clean energy system technology (WE-NET). Subtask 5. Development of technology of hydrogen transportation/storage (3rd edition, development of liquid hydrogen storage equipment, report on results of Air Liquide); Suiso riyo kokusai clean energy system gijutsu (WE-NET). Subtask 5. Suiso yuso chozo gijutsu no kaihatsu (daisanpen ekitai suiso chozo setsubi no kaihatsu Air Liquide sha seika hokoku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    In the fiscal 1995 study, items were searched which are keys to the design of a liquid hydrogen tanker of a capacity of 200,000m{sup 3}. Among those, the basic concepts were summarized which are necessary for the design of a liquid hydrogen tanker in terms of safety, and the extraporation of the existing low temperature technology into the large liquid hydrogen tank was studied. When adopting safety conditions of IGC Code applied to LNG to the liquid hydrogen tanker, it is necessary to limit the discharge amount of hydrogen to 3 kg/s. When considering safety at fire, for keeping safety of the same level as that of the LNG tanker, it is not appropriate to adopt the conventional vacuum insulation liquid hydrogen tank. In the fiscal 1995 study, 7 kinds of concept of the insulation structure were assumed, and it was concluded that BOR of 0.04-0.23/d was obtained. Also in fiscal 1996, the large liquid hydrogen tank was studied. For insulation of the large liquid hydrogen tank, the structure is most promising where AEROSIL bag or homogeneous AEROSIL is substituted for a forming heat insulating material of 4 design, but further study is needed for selection of the optimum heat insulating structure. 9 figs., 6 tabs.

  20. 3rd IDPASC School

    CERN Document Server

    Lectures on particle physics, astrophysics and cosmology

    2015-01-01

    This volume gathers the content of the courses held at the Third IDPASC School, which took place in San Martiño Pinario, Hospederia and Seminario Maior, in the city of Santiago de Compostela, Galiza, Spain, from January 21st to February 2nd, 2013. This school is the annual joint program of the International Doctorate Network in Particle Physics, Astrophysics, and Cosmology (IDPASC).   The purpose of the school series is to present doctoral students from different universities and laboratories in Europe and beyond with a broad range of the latest results and current state of the art in the fields of Particle Physics, Astrophysics, and Cosmology, and to further introduce them to both the questions now posed by the potentials of physics and to challenges connected with current and future experiments – in particular, with the newly available energy ranges.   Following these guidelines, the content of this third edition of the IDPASC School was jointly planned by the Academic Council and by the network’s In...

  1. Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities, 3rd edition.

    Science.gov (United States)

    Gelband, Hellen; Sankaranarayanan, Rengaswamy; Gauvreau, Cindy L; Horton, Susan; Anderson, Benjamin O; Bray, Freddie; Cleary, James; Dare, Anna J; Denny, Lynette; Gospodarowicz, Mary K; Gupta, Sumit; Howard, Scott C; Jaffray, David A; Knaul, Felicia; Levin, Carol; Rabeneck, Linda; Rajaraman, Preetha; Sullivan, Terrence; Trimble, Edward L; Jha, Prabhat

    2016-05-21

    Investments in cancer control--prevention, detection, diagnosis, surgery, other treatment, and palliative care--are increasingly needed in low-income and particularly in middle-income countries, where most of the world's cancer deaths occur without treatment or palliation. To help countries expand locally appropriate services, Cancer (the third volume of nine in Disease Control Priorities, 3rd edition) developed an essential package of potentially cost-effective measures for countries to consider and adapt. Interventions included in the package are: prevention of tobacco-related cancer and virus-related liver and cervical cancers; diagnosis and treatment of early breast cancer, cervical cancer, and selected childhood cancers; and widespread availability of palliative care, including opioids. These interventions would cost an additional US$20 billion per year worldwide, constituting 3% of total public spending on health in low-income and middle-income countries. With implementation of an appropriately tailored package, most countries could substantially reduce suffering and premature death from cancer before 2030, with even greater improvements in later decades.

  2. Caution required for handling genome editing technology.

    Science.gov (United States)

    Araki, Motoko; Nojima, Kumie; Ishii, Tetsuya

    2014-05-01

    Genome-editing technology, although a robust tool for genetic engineering, is creating indistinct regulatory boundaries between naturally occurring and modified organisms. However, researchers must act with caution in research and development to avoid misleading society. Furthermore, appropriate regulations should be proactively discussed and established for handling genome-editing technology.

  3. A Beginning. Revised 3rd Edition.

    Science.gov (United States)

    Healy, Mary K.; Root, Phyllis

    This document contains a selection of materials focusing on man acting to know, preserve, and improve his environment. The booklet is divided into three parts. Part one presents a listing of objectives. They reflect a need for all to become aware of the problems that plague our environment. Furthermore, they indicate that the ecological…

  4. DDN New User Guide, 3rd Edition

    Science.gov (United States)

    1993-04-05

    incomplete or incorrect address is returned to the sender with an error message. If a mail message is undeliverable due to network or machine problems, most... mail programs try to resend it several times before returning it to the sender . Many mail programs allow you to use a local text editor to revise or...username and password. These may be entered in either upper or lowercase. After a successful login, InfoMail notifies user of mail in his " Inbox ." INBOX

  5. Introduction to Surgical Technology. Third Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Bushey, Vicki; Hildebrand, Bob; Hildebrand, Dinah; Johnson, Dave; Sikes, John; Tahah, Ann; Walker, Susan; Zielsdorf, Lani

    These teacher and student editions provide instructional materials for an introduction to surgical technology course. Introductory materials in the teacher edition include information on use, instructional/task analysis, academic and workplace skill classifications and definitions, related academic and workplace skill list, and crosswalk to…

  6. The commercialization of genome-editing technologies.

    Science.gov (United States)

    Brinegar, Katelyn; K Yetisen, Ali; Choi, Sun; Vallillo, Emily; Ruiz-Esparza, Guillermo U; Prabhakar, Anand M; Khademhosseini, Ali; Yun, Seok-Hyun

    2017-11-01

    The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.

  7. The 3rd International Symposium on Avian Brood Parasitism

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    正Invited participants on the 3rd International Symposium on Avian Brood Parasitism, sponsored by Hainan Normal University (HNU), China, Norwegian University of Science and Technology (NTNU), Norway, the Research Council of Norway, and China Ornithological Society (COS).

  8. 深圳天麓三区种植屋面施工技术%Shenzhen Tianlu 3rd Zone planted roof construction technology

    Institute of Scientific and Technical Information of China (English)

    石伟国

    2011-01-01

    In Shenzhen Tianlu 3rd Zone Rhine Castle project, basement roof is designed as the sky garden, and it is planted roof above the waterproof layer. This paper introduces the waterproof design scheme, waterproof material characteristics, roof greening, and construction process of the planted roof.%深圳天麓三区莱茵堡项目地下室顶板设计为空中花园,防水层上为种植屋面.介绍该种植屋面防水设计方案、防水材料特点、屋面绿化及种植屋面的施工工艺.

  9. Emerging technologies planning guide, 1993 edition

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    Information system technology enhancements during the next five years are expected to provide some of the most significant individual and organization work improvements ever made in the office environment. This guide is an aid to planning these technologies and assessing their roles in improving the effectiveness of Headquarters programs. Their implementation will cost-effectively support Departmental operations and the National Energy Strategy. At the hear of this process is an understanding of the relationship which exists between technology introduction and the planning, budgeting and acquisition process. The 1993 edition of this guide covers the 1993--1997 time frame.

  10. Technology Roadmap: Wind Energy. 2013 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The IEA Wind Power Technology Roadmap 2013 Edition recognises the very significant progress made since the first edition was published in 2009. The technology continues to improve rapidly, and costs of generation from land-based wind installations continue to fall. Wind power is now being deployed in countries with good resources without any dedicated financial incentives. The 2013 Edition targets an increased share (15% to 18%) of global electricity to be provided by wind power in 2050, compared to 12% in the original roadmap of 2009. However, increasing levels of low-cost wind still require predictable, supportive regulatory environments and appropriate market designs. The challenges of integrating higher levels of variable wind power into the grid need to be addressed. For offshore wind, much remains to be done to develop appropriate large-scale systems and to reduce costs. The 2013 Wind Power Roadmap also provides updated analysis on the barriers that exist for the technology and suggests ways to address them, including legal and regulatory recommendations.

  11. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  12. Lecture Notes in Statistics. 3rd Semester

    DEFF Research Database (Denmark)

    The lecture note is prepared to meet the requirements of the curriculum for the 3rd smester course in statistics at the Aarhus School of Business.......The lecture note is prepared to meet the requirements of the curriculum for the 3rd smester course in statistics at the Aarhus School of Business....

  13. Lecture Notes in Statistics. 3rd Semester

    DEFF Research Database (Denmark)

    The lecture note is prepared to meet the requirements of the curriculum for the 3rd smester course in statistics at the Aarhus School of Business.......The lecture note is prepared to meet the requirements of the curriculum for the 3rd smester course in statistics at the Aarhus School of Business....

  14. 3rd International Conference on Ecosystem Assessment Management

    CERN Document Server

    Ma, Sheng-Quan; Cao, Hu-hua; Ecosystem Assessment and Fuzzy Systems Management

    2014-01-01

    “Ecosystem Assessment and Fuzzy Systems Management” is the edited outcome of the 3rd International Conference on Ecosystem Assessment Management (ICEAM) and the Workshop on the Construction of an Early Warning Platform for Eco-tourism (WCEWPE) in Hainan on May 5-12, 2013, Haikou, China. The 3rd ICEAM and the WCEWPE, built on the success of previous conferences, are major Symposiums for scientists, engineers and logistic management researchers presenting their the latest achievements, developments and applications in all areas of Ecosystem Assessment Management, Early Warning Platform for Eco-tourism and fuzziology. It aims to strengthen relations between industry research laboratories and universities, and to create a primary symposium for world scientists. The book, containing 47 papers, is divided into five parts: “Ecosystem Assessment, Management and Information”; “Intelligent Algorithm, Fuzzy Optimization and Engineering Application”; “Spatial Data Analysis and Intelligent Information Proces...

  15. Medical-Surgical Nursing Luckmann J , Sorensen K C Medical-Surgical Nursing 3rd edition W B Saunders 2126pp ţ39.50 0-7216-5815-6.

    Science.gov (United States)

    1988-01-09

    While reviewing Joan Luckmann and Karen Sorensen's latest edition, I was reminded of an old tutor who when presented with a hefty study or project by one his students used to throw it on his desk, wait for effect, and then comment 'Hmmm...about the right weight.' This edition, like its predecessor, is not only hefty but 'the right weight' in the sense that the old tutor always meant - its range and scope of content. The sheer volume of content remains impressive indeed.

  16. Lecture Notes in Statistics. 3rd Semester

    DEFF Research Database (Denmark)

    The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models.......The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models....

  17. Lecture Notes in Statistics. 3rd Semester

    DEFF Research Database (Denmark)

    The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models.......The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models....

  18. Microstructure and Performance Control Technology of the 3rd Generation Auto Sheet Steels%第3代汽车钢的组织与性能调控技术

    Institute of Scientific and Technical Information of China (English)

    董瀚; 曹文全; 时捷; 王存宇; 王毛球; 翁宇庆

    2011-01-01

    介绍了第3代汽车钢的基础研究与工业试制工作.对国内外高性能汽车钢进行了回顾总结,在以"多相(Multi-phase)、亚稳(Meta-stable)、多尺度(Multi-scale)"(简称M3)为特征的组织调控理论的指导下,提出了高强塑积第3代汽车钢的超细晶基体与亚稳相的组织调控思路,采用了新型中锰合金化和逆转变奥氏体(Austenite Reverted Transformation,ART)退火的技术思路.详细介绍了第3代汽车钢的基础研究进展及工业试制结果,内容包括奥氏体逆转变退火机制,超细铁素体与亚稳奥氏体的双相形成规律,高强塑积汽车钢的力学行为及其强塑化机制,第3代汽车钢的工业试制流程及其服役性能和在汽车上应用技术与前景.本研究结果形成了以高强度和高塑性为特征的高塑积第3代汽车钢的原型钢技术,为汽车轻量化与碰撞安全性能的提高奠定了材料技术基础.%The fundamental research and industry trials of the 3rd generation automobile steels was introduced. Motivitated by the theory of microstructure control characterized by Multi-phase, Meta-stable and Multi-scale(called M3 simply), summary and review of the home and abroad automobile steels were carried out, which led to the idea microstructure controlling characterized by ultrafine grained matrix and metastable austenite phase and the approaches of medium manganese alloying and austenite reverted transformation annealing for the research and development of the 3rd generation automobile steel. The fundamental research and industry trials were introduced in details, which included the mechanism of austenite reverted transformation, microstructure evolution of the ultrafine grained ferrite and austenite dualphase structure, mechanical behaviors and ductility-enhancing mechanism, industry trial process, service performance and application technologies and prospects of the 3rd generation steels. It was concluded that this study forms the

  19. 3rd Semester and Master's Thesis Ideas

    DEFF Research Database (Denmark)

    Clausen, Johan

    The following pages contain a list of project ideas proposed by the scientific staff at the department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalouge may form the basis for long and short candidate projects as well as regular 3rd s...

  20. Analysis of the Practice Guideline for the Treatment of Patients with Major Depressive Disorder in APA, 3rd Edition%美国精神病协会抑郁障碍患者治疗实践指南(第三版)解析

    Institute of Scientific and Technical Information of China (English)

    王学义; 李凝

    2012-01-01

    The American Psychiatric Association (APA) made the new practice guideline for the treatment of patients with major depressive disorder, and the practice guideline for the treatment of patients with major depressive disorder, 3rd edition has been published in October 2010. The new guideline mainly consists of three parts( A,B and C) .adding the newest evidence-based medical evidences and treatment ideas. Part A involves the treatment advice;part B involves the background and assessment among the data presented; part C involves the problems to be resolved in the future researches. Every part has been given some analyses.%美国精神病协会(APA)于2010年10月出版了《抑郁障碍患者治疗实践指南,第3版》.新版指南增加了最新的循证医学证据和治疗理念,由三部分(A、B、C)组成.A部分是治疗建议,B部分是背景资料和现有证据评价,C部分是未来研究的问题.每部分均作了相应的的解读.

  1. Modern Genome Editing Technologies in Huntington's Disease Research.

    Science.gov (United States)

    Malankhanova, Tuyana B; Malakhova, Anastasia A; Medvedev, Sergey P; Zakian, Suren M

    2017-01-01

    The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study NgAgo human diseases at the cellular and molecular levels. Gene editing tools like ZFN, TALEN, CRISPR-based systems, NgAgo and SGN can introduce different modifications. In gene sequences and regulate gene expression in different types of cells including induced pluripotent stem cells (iPSCs). These tools can be successfully used for Huntington's disease (HD) modeling, for example, to generate isogenic cell lines bearing different numbers of CAG repeats or to correct the mutation causing the disease. This review presents common genome editing technologies and summarizes the progress made in using them in HD and other hereditary diseases. Furthermore, we will discuss prospects and limitations of genome editing in understanding HD pathology.

  2. Genome editing: a robust technology for human stem cells.

    Science.gov (United States)

    Chandrasekaran, Arun Pandian; Song, Minjung; Ramakrishna, Suresh

    2017-09-01

    Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells.

  3. Resource Guide to Careers in Toxicology, 3rd Edition.

    Science.gov (United States)

    Society of Toxicology, Reston, VA.

    This resource guide was prepared by the Tox 90's Educational Issues Task Force of the Society of Toxicology. The introduction provides information on the Society of Toxicology and financial support for graduate students in toxicology. Other sections include career opportunities in toxicology, academic and postdoctoral programs in toxicology, and…

  4. Diagnosis and Fault-tolerant Control, 3rd Edition

    DEFF Research Database (Denmark)

    Blanke, Mogens; Kinnaert, Michel; Lunze, Jan;

    The book presents effective model-based analysis and design methods for fault diagnosis and fault-tolerant control. Architectural and structural models are used to analyse the propagation of the fault through the process, to test the fault detectability and to find the redundancies in the process...

  5. Legal Concepts in Sport: A Primer. 3rd Edition

    Science.gov (United States)

    Carpenter, Linda Jean

    2008-01-01

    When most people think of legal issues in sport, they think about negligence. However, most professionals will face a much broader range of issues. For instance, topics such as sexual harassment, corporal punishment, drug testing, transportation, and hazing are all of special importance today. Also anti-discrimination laws and the concepts…

  6. Machining Data Handbook. 3rd Edition. Volume 2

    Science.gov (United States)

    1980-01-01

    Hobbing 7.1 i TMERA FEDrPER IMT:" NUBE REVOLUJTION HOB HSS TOOL MATERIAL HR- CONDITION OFHNUME OF jSPED MAEI. NESSur WORKPIECE I 1m AS 80 15 8 1 1- 2 I...Shaping 7.3 DIAMETRAL IROTARY FEED NUBE ITH per cuter CUTTER HSS TOOL MAEILHARD- NUMDITEO POTC stroke SPEED MATERIAL MATEIALNESS CODUTOSO -7- (411 P.D

  7. Performance Indicators for Microfinance Institutions: Technical Guide: 3rd edition

    OpenAIRE

    Damian von Stauffenberg; Tor Jansson; Naomi Kenyon; María-Cruz Barluenga-Badiola

    2003-01-01

    This technical guide highlights 14 of the most commonly used indicators published by the Roundtable Group and illustrates how they are used. It provides some explanation and analysis of the indicators for those who are interested in understanding their application as well as weaknesses. For each indicator, the Guide presents the proposed definition, interprets its meaning, identifies potential pitfalls in its use, and provides benchmark values for 32 Latin American microfinance institutions c...

  8. Guidelines for chemical peeling in Japan (3rd edition).

    Science.gov (United States)

    2012-04-01

    Chemical peeling may be defined as the therapies, procedures and techniques used for the treatment of certain cutaneous diseases or conditions, and for aesthetic improvement. The procedures include the application of one or more chemical agents to the skin. Chemical peeling has been very popular in both medical and aesthetic fields. Because neither its scientific background is well understood nor a systematic approach established, medical and social problems have taken place. This prompted us to establish and distribute a standard guideline of care for chemical peeling. Previous guidelines such as the 2001 and 2004 versions included minimum standards of care such as indications, chemicals, applications, and any associated precautions, including post-peeling care. The principles in this updated version of chemical peeling are as follows: (i) chemical peeling should be performed under the strict technical control and responsibility of a physician; (ii) the physician should have sufficient knowledge of the structure and physiology of the skin and subcutaneous tissues, and understand the mechanisms of wound-healing induced by chemical peeling; (iii) the physician should be board-certified in an appropriate specialty such as dermatology; and (iv) the ultimate judgment regarding the appropriateness of any specific chemical peeling procedure must be made by the physician while considering all standard therapeutic protocols, which should be presented to each individual patient. Keeping these concepts in mind, this new version of the guidelines includes a more scientific and detailed approach from the viewpoint of evidence-based medicine.

  9. Thermal radiation heat transfer (3rd revised and enlarged edition)

    Science.gov (United States)

    Siegel, Robert; Howell, John R.

    1992-01-01

    This book first reviews the overall aspects and background information related to thermal radiation heat transfer and incorporates new general information, advances in analytical and computational techniques, and new reference material. Coverage focuses on radiation from opaque surfaces, radiation interchange between various types of surfaces enclosing a vacuum or transparent medium, and radiation including the effects of partially transmitting media, such as combustion gases, soot, or windows. Boundary conditions and multiple layers are discussed with information on radiation in materials with nonunity refractive indices.

  10. Airfield construction (3rd revised and enlarged edition)

    Science.gov (United States)

    Goretskii, Leonid I.; Boguslavskii, Adol'f. M.; Serebrenikov, Vadim A.; Barzdo, V. I.; Leshchitskaia, T. P.; Polosin-Nikitin, S. M.

    The principal engineering aspects of airfield construction are discussed. In particular, attention is given to the fundamental principles and organizational aspects of airfield construction; excavation work and airfield layout; construction of drainage systems; foundations and pavements; and quality control and safety engineering. The discussion also covers the operation of various support plants, including concrete production and mixing, production of asphalt-concrete mixtures and organic binders, production of structural steel and reinforced concrete components, and operation of stone quarries and gravel pits.

  11. Field Trials of Health Interventions, 3rd edition

    OpenAIRE

    Smith, Peter G; Richard H. Morrow; David A Ross

    2015-01-01

    Before new interventions can be used in disease control programmes, it is essential that they are carefully evaluated in “field trials”, which may be complex and expensive undertakings. Descriptions of the detailed procedures and methods used in trials that have been conducted in the past have generally not been published. As a consequence, those planning such trials have few guidelines available and little access to previously accumulated knowledge. In this book the practical issues of trial...

  12. Legal Concepts in Sport: A Primer. 3rd Edition

    Science.gov (United States)

    Carpenter, Linda Jean

    2008-01-01

    When most people think of legal issues in sport, they think about negligence. However, most professionals will face a much broader range of issues. For instance, topics such as sexual harassment, corporal punishment, drug testing, transportation, and hazing are all of special importance today. Also anti-discrimination laws and the concepts…

  13. Fact book on aging in British Columbia, 3rd Edition

    OpenAIRE

    Gutman, Gloria M.; Andrew V. Wister; Carriere, Yves; Tredwell, Susannah

    2000-01-01

    Table of ContentsForeword; 1. Size of the Elderly Population; 1.1 Past Trends and Future Growth; 1.2 Population Aging Within the Older Population Itself; 1.3 Median Age of the Population; 2. Sex Ratio; 3. Mortality; 3.1 Trends in Life Expectancy; 3.2 Deaths and Mortality Rates; 3.3 Causes of Death; 3.4 Cancer; 4. Marital Status; 5. Geographic Distribution and Mobility; 5.1 The Older Population of B.C. in Relation to Other Provinces; 5.2 Rural-Urban Distribution; 5.3 Geographic Distribution Wi...

  14. 3rd MeTrApp Conference

    CERN Document Server

    Lovasz, Erwin-Christian; Hüsing, Mathias

    2015-01-01

    This volume deals with topics such as mechanism and machine design, biomechanics and medical engineering, gears, mechanical transmissions, mechatronics, computational and experimental methods, dynamics of mechanisms and machines, micromechanisms and microactuators, and history of mechanisms and transmissions. Following MeTrApp 2011 and 2013, held under the auspices of the IFToMM, these proceedings of the 3rd Conference on Mechanisms, Transmissions and Applications offer a platform for original research presentations for researchers, scientists, industry experts and students in the fields of mechanisms and transmissions with special emphasis on industrial applications in order to stimulate the exchange of new and innovative ideas.

  15. 3rd International Workshop on Computational Engineering

    CERN Document Server

    Bischoff, Manfred; Schäfer, Michael

    2015-01-01

    This book presents selected papers from the 3rd International Workshop on Computational Engineering held in Stuttgart from October 6 to 10, 2014, bringing together innovative contributions from related fields with computer science and mathematics as an important technical basis among others. The workshop discussed the state of the art and the further evolution of numerical techniques for simulation in engineering and science. We focus on current trends in numerical simulation in science and engineering, new requirements arising from rapidly increasing parallelism in computer architectures, and novel mathematical approaches. Accordingly, the chapters of the book particularly focus on parallel algorithms and performance optimization, coupled systems, and complex applications and optimization.

  16. 3rd Conference on Ignition Systems for Gasoline Engines

    CERN Document Server

    Sens, Marc

    2017-01-01

    The volume includes selected and reviewed papers from the 3rd Conference on Ignition Systems for Gasoline Engines in Berlin in November 2016. Experts from industry and universities discuss in their papers the challenges to ignition systems in providing reliable, precise ignition in the light of a wide spread in mixture quality, high exhaust gas recirculation rates and high cylinder pressures. Classic spark plug ignition as well as alternative ignition systems are assessed, the ignition system being one of the key technologies to further optimizing the gasoline engine.

  17. Classificação da Organização Mundial da Saúde para os tumores dos tecidos hematopoético e linfoide, 4ª edição, 2008: principais modificações introduzidas em relação à 3ª edição, 2001 World Health Organization classification of tumors of hematopoietic and lymphoid tissues, 4th edition, 2008: major changes from the 3rd edition, 2001

    Directory of Open Access Journals (Sweden)

    Maria Claudia Nogueira Zerbini

    2011-02-01

    Full Text Available A Classificação da Organização Mundial da Saúde (OMS para os tumores do tecido hematopoético e linfoide (4ª edição, 2008¹ representa uma atualização da 3ª edição, 2001². Apresentamos a seguir um resumo dessas alterações nos grupos das doenças mieloproliferativas, mileodisplásicas, leucemias mieloides agudas, neoplasias de células precursoras B e T, e neoplasias de células B, T e NK maduras. O entendimento das alterações genético-moleculares e os resultados alcançados com propostas terapêuticas inovadoras nesses grupos de doenças demandam constante reavaliação de sua classificação, justificando as alterações importantes aqui discutidas1,3-5.The World Health Organization (WHO Classification of tumors of hematopoietic and lymphoid tissues (4th edition, 2008¹ presents an updated version of the 3rd edition published in 2001². A summary of these changes relates to the groups of chronic myeloproliferative disorders, myelodisplasia, acute myeloid leukemias, neoplasms of precursor B and T cells and neoplasms derived of mature B, T and NK cells. A better understanding of molecular genetic changes and results achieved with innovative therapeutic approaches in these groups of diseases requires constant reassessment of the classifications, supporting the major changes discussed here, including interesting comments from literature1, 3-5.

  18. 3rd International Conference Nanotechnology and Nanomaterials

    CERN Document Server

    Yatsenko, Leonid

    2016-01-01

    This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 3rd International Science and Practice Conference Nanotechnology and Nanomaterials (NANO2015) held in Lviv, Ukraine on August 26-30, 2015. The International Conference was organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), Ivan Franko National University of Lviv (Ukraine), University of Turin (Italy), Pierre and Marie Curie University (France), and European Profiles A.E. (Greece). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications. Presents cutting-edge advances in nanocomposites and carbon and silicon-based nanomaterials for a wide range of engine...

  19. AAV Vectorization of DSB-mediated Gene Editing Technologies.

    Science.gov (United States)

    Moser, Rachel J; Hirsch, Matthew L

    2016-01-01

    Recent work both at the bench and the bedside demonstrate zinc-finger nucleases (ZFNs), CRISPR/Cas9, and other programmable site-specific endonuclease technologies are being successfully utilized within and alongside AAV vectors to induce therapeutically relevant levels of directed gene editing within the human chromosome. Studies from past decades acknowledge that AAV vector genomes are enhanced substrates for homology-directed repair in the presence or absence of targeted DNA damage within the host genome. Additionally, AAV vectors are currently the most efficient format for in vivo gene delivery with no vector related complications in >100 clinical trials for diverse diseases. At the same time, advancements in the design of custom-engineered site-specific endonucleases and the utilization of elucidated endonuclease formats have resulted in efficient and facile genetic engineering for basic science and for clinical therapies. AAV vectors and gene editing technologies are an obvious marriage, using AAV for the delivery of repair substrate and/or a gene encoding a designer endonuclease; however, while efficient delivery and enhanced gene targeting by vector genomes are advantageous, other attributes of AAV vectors are less desirable for gene editing technologies. This review summarizes the various roles that AAV vectors play in gene editing technologies and provides insight into its trending applications for the treatment of genetic diseases.

  20. Using Technology with Classroom Instruction that Works. Second Edition

    Science.gov (United States)

    Kuhn, Matt; Hubbell, Elizabeth R.; Pitler, Howard

    2012-01-01

    If you've upgraded to the second edition of the landmark book "Classroom Instruction That Works," you need this companion guide to help you use technology to support research-based instruction. The authors follow the revised Instructional Planning Guide that makes it easier for you to know when to emphasize each of the instructional strategies,…

  1. Power Technologies Energy Data Book - Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2006-08-01

    This report, prepared by NREL's Strategic Energy Analysis Center, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, and conversion factors.

  2. 3rd International Conference on Nanotechnologies and Biomedical Engineering

    CERN Document Server

    Tiginyanu, Ion

    2016-01-01

    This volume presents the proceedings of the 3rd International Conference on Nanotechnologies and Biomedical Engineering which was held on September 23-26, 2015 in Chisinau, Republic of Moldova. ICNBME-2015 continues the series of International Conferences in the field of nanotechnologies and biomedical engineering. It aims at bringing together scientists and engineers dealing with fundamental and applied research for reporting on the latest theoretical developments and applications involved in the fields. Topics include Nanotechnologies and nanomaterials Plasmonics and metamaterials Bio-micro/nano technologies Biomaterials Biosensors and sensors systems Biomedical instrumentation Biomedical signal processing Biomedical imaging and image processing Molecular, cellular and tissue engineering Clinical engineering, health technology management and assessment; Health informatics, e-health and telemedicine Biomedical engineering education Nuclear and radiation safety and security Innovations and technology transfer...

  3. Biodetection Technologies for First Responders: 2014 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Ozanich, Richard M.; Baird, Cheryl L.; Bartholomew, Rachel A.; Colburn, Heather A.; Straub, Tim M.; Bruckner-Lea, Cindy J.

    2014-03-28

    This report summarizes commercially-available, hand-portable technologies that can be used by first responders in the field. This is not meant to be an exhaustive list, nor an endorsement of any technology described herein. Rather, this report is meant to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use. Information listed in this report is primarily vendor-provided; however, where possible it has been supplemented with additional information obtained from publications, reports, and websites. Manufacturers were given the chance to review summaries of their technologies from August through November 2013 to verify the accuracy of technical specifications, available references, and pricing.

  4. Genome-editing Technologies for Gene and Cell Therapy

    Science.gov (United States)

    Maeder, Morgan L; Gersbach, Charles A

    2016-01-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed. PMID:26755333

  5. Genome-editing Technologies for Gene and Cell Therapy.

    Science.gov (United States)

    Maeder, Morgan L; Gersbach, Charles A

    2016-03-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed.

  6. Genome-Editing Technologies: Principles and Applications.

    Science.gov (United States)

    Gaj, Thomas; Sirk, Shannon J; Shui, Sai-Lan; Liu, Jia

    2016-12-01

    Targeted nucleases have provided researchers with the ability to manipulate virtually any genomic sequence, enabling the facile creation of isogenic cell lines and animal models for the study of human disease, and promoting exciting new possibilities for human gene therapy. Here we review three foundational technologies-clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs). We discuss the engineering advances that facilitated their development and highlight several achievements in genome engineering that were made possible by these tools. We also consider artificial transcription factors, illustrating how this technology can complement targeted nucleases for synthetic biology and gene therapy.

  7. 3rd Symposium on Space Optical Instruments and Applications

    CERN Document Server

    Zhang, Guangjun

    2017-01-01

    This volume contains selected and expanded contributions presented at the 3rd Symposium on Space Optical Instruments and Applications in Beijing, China June 28 – 29, 2016. This conference series is organised by the Sino-Holland Space Optical Instruments Laboratory, a cooperation platform between China and the Netherlands. The symposium focused on key technological problems of optical instruments and their applications in a space context. It covered the latest developments, experiments and results regarding theory, instrumentation and applications in space optics. The book is split across five topical sections. The first section covers space optical remote sensing system design, the second advanced optical system design, the third remote sensor calibration and measurement. Remote sensing data processing and information extraction is then presented, followed by a final section on remote sensing data applications. .

  8. 3rd International Conference on Computational Mathematics and Computational Geometry

    CERN Document Server

    Ravindran, Anton

    2016-01-01

    This volume presents original research contributed to the 3rd Annual International Conference on Computational Mathematics and Computational Geometry (CMCGS 2014), organized and administered by Global Science and Technology Forum (GSTF). Computational Mathematics and Computational Geometry are closely related subjects, but are often studied by separate communities and published in different venues. This volume is unique in its combination of these topics. After the conference, which took place in Singapore, selected contributions chosen for this volume and peer-reviewed. The section on Computational Mathematics contains papers that are concerned with developing new and efficient numerical algorithms for mathematical sciences or scientific computing. They also cover analysis of such algorithms to assess accuracy and reliability. The parts of this project that are related to Computational Geometry aim to develop effective and efficient algorithms for geometrical applications such as representation and computati...

  9. Progress in Genome Editing Technology and Its Application in Plants

    OpenAIRE

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, pr...

  10. Genome-Editing Technologies for Enhancing Plant Disease Resistance

    Science.gov (United States)

    Andolfo, Giuseppe; Iovieno, Paolo; Frusciante, Luigi; Ercolano, Maria R.

    2016-01-01

    One of the greatest challenges for agricultural science in the 21st century is to improve yield stability through the progressive development of superior cultivars. The increasing numbers of infectious plant diseases that are caused by plant-pathogens make it ever more necessary to develop new strategies for plant disease resistance breeding. Targeted genome engineering allows the introduction of precise modifications directly into a commercial variety, offering a viable alternative to traditional breeding methods. Genome editing is a powerful tool for modifying crucial players in the plant immunity system. In this work, we propose and discuss genome-editing strategies and targets for improving resistance to phytopathogens. First of all, we present the opportunities to rewrite the effector-target sequence for avoiding effector-target molecular interaction and also to modify effector-target promoters for increasing the expression of target genes involved in the resistance process. In addition, we describe potential approaches for obtaining synthetic R-genes through genome-editing technologies (GETs). Finally, we illustrate a genome editing flowchart to modify the pathogen recognition sites and engineer an R-gene that mounts resistance to some phylogenetically divergent pathogens. GETs potentially mark the beginning of a new era, in which synthetic biology affords a basis for obtaining a reinforced plant defense system. Nowadays it is conceivable that by modulating the function of the major plant immunity players, we will be able to improve crop performance for a sustainable agriculture. PMID:27990151

  11. Newer Gene Editing Technologies toward HIV Gene Therapy

    Directory of Open Access Journals (Sweden)

    Premlata Shankar

    2013-11-01

    Full Text Available Despite the great success of highly active antiretroviral therapy (HAART in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called “Berlin patient” who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  12. Newer gene editing technologies toward HIV gene therapy.

    Science.gov (United States)

    Manjunath, N; Yi, Guohua; Dang, Ying; Shankar, Premlata

    2013-11-14

    Despite the great success of highly active antiretroviral therapy (HAART) in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called "Berlin patient" who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  13. 3rd August 2010 - CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt, signing the guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1008148 11: H. von Dewitz in the ATLAS Visitor centre with Collaboration member M. Hauschild (left) and Former IT Department Head W. von Rüden (right) CERN-HI-1008148 18 : Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid (left) in the ATLAS Visitor centre with Collaboration member M. Hauschild. CERN-HI-1008148: in the ATLAS visitor centre, from left to right: Former IT Department Head W. von Rüden; ATLAS Collaboration P. Mättig; CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt; Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid; H. von Dewitz; ATLAS Collaboration member M. Hauschild.

  14. Developing Product Lines with 3rd-party components

    NARCIS (Netherlands)

    De Jonge, M.

    2007-01-01

    The trends toward product line development and toward adopting more 3rd-party software are hard to combine. The reason is that productlines demand fine control over the software (e.g., for diversity management), while 3rd-party software (almost by definition) provides only little or no control. A

  15. Research progress of genome editing and derivative technologies in plants.

    Science.gov (United States)

    Qiwei, Shan; Caixia, Gao

    2015-10-01

    Genome editing technologies using engineered nucleases have been widely used in many model organisms. Genome editing with sequence-specific nuclease (SSN) creates DNA double-strand breaks (DSBs) in the genomic target sites that are primarily repaired by the non-homologous end joining (NHEJ) or homologous recombination (HR) pathways, which can be employed to achieve targeted genome modifications such as gene mutations, insertions, replacements or chromosome rearrangements. There are three major SSNs─zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) system. In contrast to ZFN and TALEN, which require substantial protein engineering to each DNA target, the CRISPR/Cas9 system requires only a change in the guide RNA. For this reason, the CRISPR/Cas9 system is a simple, inexpensive and versatile tool for genome engineering. Furthermore, a modified version of the CRISPR/Cas9 system has been developed to recruit heterologous domains that can regulate endogenous gene expression, such as activation, depression and epigenetic regulation. In this review, we summarize the development and applications of genome editing technologies for basic research and biotechnology, as well as highlight challenges and future directions, with particular emphasis on plants.

  16. The EDIT school trains future experts in detector technologies

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    The Excellence in Detectors and Instrumentation Technologies (EDIT) School has just taken place for the first time. The enthusiastic feedback from the organizers and the participants shows how the School’s format is just the right formula for today’s young researchers specializing in experimental physics. To mark the importance of the event, Rolf Heuer dedicated the School to Georges Charpak.   Rolf Heuer and Pier Oddone visit Building 154, which hosted some of the EDIT School laboratory activities. Like many other branches of science, today’s particle physics relies on very complex instruments to provide the performance that unresolved questions require. When we say ‘particle physics’ we actually mean a whole lot of different specializations that young researchers choose to pursue when they are at university. “In the present situation, it might very well happen that an experimental particle physicist at the end of his/her studies has ne...

  17. 3rd Developers@CERN Forum

    CERN Document Server

    CERN. Geneva

    2017-01-01

    It's about U and I !   The Developers@CERN Forum is an event by developers, for developers, aimed at promoting knowledge and experience sharing. This edition will take place at the IT Amphitheatre, on the 13th, 14th and 15th of February afternoons. It will consist of a series of short presentations and workshops. The topic for this conference will be Frontend & User interfaces. Have you got an idea for a presentation or workshop? Then, tell us about it (deadline on 27th of January). Registration will open in November. Please subscribe to developers-forum-announce@cern.ch mailing list for further information. This event will be made by developers for developers. We are counting on your presence, but also on your contributions! To learn more about the initiative, read the CERN Bulletin article. Organization You can get in touch us at developers-forum-organizers@cern.ch.

  18. A Celebration for Chinese Auto Elite——The 3rd China International Bus Competition

    Institute of Scientific and Technical Information of China (English)

    Li Yinghong; Sun Yongjian

    2007-01-01

    @@ The awarding ceremony of the 3rd China International Bus Competition (CIBC) was held in Beijing on April 18, 2007. The competition was jointly sponsored by the Urban Vehicle Expert Committee of the Scientific and Technology Committee, the Ministry of Construction, China Highway Academy Passenger Car Branch, China Road Transportation Association, China Urban Traffic Association and China Travel Vehicle and Ship Association.

  19. CRISPR/Cas9 technology for targeted genome editing

    Directory of Open Access Journals (Sweden)

    Lomov N. A.

    2015-08-01

    Full Text Available CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats are the segments of prokaryotic DNA containing short repeats in its nucleotide sequence. Today we know that this is a bacterial protection system against viral DNA. The molecular components of CRISPR/Cas9 system have been used for a gene editing in eukaryotes since 2013. But as any other method it also has the limitations and drawbacks. Here we are going to review the history of CRISPR biology and to discuss the possibilities that this new technology provides to researchers as well as the prospects for its use in the medical research and treatment.

  20. The 3rd colloquium on process simulation. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Jokilaakso, A. [ed.

    1996-12-31

    The presentations collected in this volume were presented at the 3rd Colloquium on Process Simulation held at Helsinki University of Technology, Espoo, Finland, June 12-14, 1996. In the more developed industrial nations, the processes for producing chemicals, energy, and materials encounter environmental concern and laws which challenge engineers to develop the processes towards more efficient, economical and safe operation. This necessitates more thorough understanding of the processes and phenomena involved. Formerly, the development of the processes was largely based on trial and error, whereas today, the development of computer performance together with the diversification of modelling software enables simulation of the processes. The increased capacity and possibilities for modelling the processes brought by the improved hardware and software, have generated a strong demand for more accurate mathematical descriptions of the processes. Especially, the coupling of computational fluid dynamics and chemical kinetics, combustion, and thermodynamics is of current interest in process oriented technology. This colloquium attempts to give examples of modelling efforts in operation in different universities, research institutes and companies. Furthermore, the aim of this colloquium is to offer an annual opportunity to the researchers to come together and discuss their common problems and the state of their investigations

  1. 3rd Annual Workshop on Inverse Problem

    CERN Document Server

    2015-01-01

    This proceeding volume is based on papers presented on the Third Annual Workshop on Inverse Problems which was organized by the Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, and took place in May 2013 in Stockholm. The purpose of this workshop was to present new analytical developments and numerical techniques for solution of inverse problems for a wide range of applications in acoustics, electromagnetics, optical fibers, medical imaging, geophysics, etc. The contributions in this volume reflect these themes and will be beneficial to researchers who are working in the area of applied inverse problems.

  2. Academic Training: 3rd Term - 01 April - 30 June 2005

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004 - 2005 ACADEMIC TRAINING PROGRAMME 3rd Term - 01 April - 30 June 2005 REGULAR LECTURE PROGRAMME Monte Carlo generators fot the LHC by T. Sjostrand / CERN-PH 4, 5, 6, 7 April The LHC machine experiment interface by S. Tapprogge / Univ. Gutenberg, Mainz, D R. Assmann, CERN-AB, E. Tsesmelis and D. Macina / CERN-TS 18, 19, 20, 21, 22 April Cosmology for particle physicists by S. Carroll / Univ. of Chicago, USA 9, 10, 11, 12, 13 May The ITER projects: technological challenges by P. Bruzzone / EPFL CRPP, Zürich, CH J. Lister / EPFL CRPP, Lausanne, CH 30, 31 May, 1, 2, 3 June String theory by C. Johnson / Univ. of Southern California, USA 6, 7, 8, 9, 10 June Small may be beautiful By M. Davier / LAL, Orsay, F. T. Soldner / ILL, Grenoble, F. 13, 14, 15, 16, 17 June Climate change and challenges for the environment by C. Schluchter / Univ. Bern. CH 20, 21, 22 June LECTURE SERIES FOR POSTGRADUATE STUDENTS Particle detectors - principles and techniques by C. Joram, L. Ropelewski, M. Moll, C. ...

  3. 3rd international conference, LDIC 2012

    CERN Document Server

    Scholz-Reiter, Bernd; Thoben, Klaus-Dieter

    2013-01-01

    The volume comprises the proceedings of the third International Conference on Dynamics in Logistics LDIC 2012. The scope of the conference targeted the identification, analysis, and description of the dynamics of logistic processes and networks. The spectrum ranged from the modeling and planning of processes and innovative methods like autonomous control and knowledge management to the new technologies provided by radio frequency identification, mobile communication, and networking. The growing dynamics in the area of logistics poses completely new challenges: Logistic processes and networks must rapidly and flexibly adapt to continuously changing conditions. LDIC 2012 provided a venue for researchers from academia and industry interested in the technical advances in dynamics in logistics. The conference addressed research in logistics from a wide range of fields, e.g. engineering, computer science and operations research. The volume consists of two invited papers and of 49 contributed papers divided into var...

  4. 3rd International Conference of Serviceology

    CERN Document Server

    Spohrer, James; Kwan, Stephen; Takenaka, Takeshi

    2017-01-01

    Services are key activities in a globalized economy and they also underlie the quality of life of local residents. The advanced work presented in this book was selected from the proceedings of the Third International Conference on Serviceology (ICServ2015), held July 7–9, 2015, in San Jose, CA, USA. The conference was supported by the Society for Serviceology. The society was established in 2012 in Japan to explore the scientific systematization of services and to promote technological developments for solutions to industrial issues. This book provides a useful general guide to the state of the art in the theory and practice of services. It can also serve as a valuable reference book for researchers in a wide range of fields from engineering to marketing and economics.

  5. 3rd International symposium on ambient intelligence

    CERN Document Server

    Tapia, Dante I; Novais, Paulo; ISAmI 2012; Ambient Intelligence : Software and Applications

    2012-01-01

    Ambient Intelligence (AmI) is a recent paradigm emerging from Artificial Intelligence (AI), where computers are used as proactive tools assisting people with their day-to-day activities, making everyone’s life more comfortable. Another main concern of AmI originates from the human computer interaction domain and focuses on offering ways to interact with systems in a more natural way by means user friendly interfaces. This field is evolving quickly as can be witnessed by the emerging natural language and gesture based types of interaction. The inclusion of computational power and communication technologies in everyday objects is growing and their embedding into our environments should be as invisible as possible. In order for AmI to be successful, human interaction with computing power and embedded systems in the surroundings should be smooth and happen without people actually noticing it. The only awareness people should have arises from AmI: more safety, comfort and wellbeing, emerging in a natural and inh...

  6. Intelligent Technologies for Interactive Entertainment

    NARCIS (Netherlands)

    Nijholt, A.; Reidsma, D.; Hondorp, G.H.W.

    2009-01-01

    These are the proceedings of the 3rd International Conference on Intelligent Technologies for Interactive Entertainment (INTETAIN 09). The first edition of this conference, organised in Madonna di Campiglio, saw the gathering of a diverse audience with broad and varied interests. With presentations

  7. PREFACE: 3rd International Symposium ''Optics and its Applications''

    Science.gov (United States)

    Calvo, M. L.; Dolganova, I. N.; Gevorgyan, N.; Guzman, A.; Papoyan, A.; Sarkisyan, H.; Yurchenko, S.

    2016-01-01

    The SPIE.FOCUS Armenia: 3rd International Symposium ''Optics and its Applications'' (OPTICS-2015) http://rau.am/optics2015/ was held in Yerevan, Armenia, in the period October 1 - 5, 2015. The symposium was organized by the International Society for Optics and Photonics (SPIE), the Armenian SPIE student chapter with collaboration of the Armenian TC of ICO, the Russian-Armenian University (RAU), the Institute for Physical Research of National Academy of Sciences of Armenia (IPR of NAS), the Greek-Armenian industrial company LT-PYRKAL, and the Yerevan State University (YSU). The Symposium was co-organized by the SPIE & OSA student chapters of BMSTU, the Armenian OSA student chapter, and the SPIE student chapters of Lund University and Wroclaw University of Technology. The symposium OPTICS-2015 was dedicated to the International Year of Light and Light-Based Technologies. OPTICS-2015 was devoted to modern topics and optical technologies such as: optical properties of nanostructures, silicon photonics, quantum optics, singular optics & its applications, laser spectroscopy, strong field optics, biomedical optics, nonlinear & ultrafast optics, photonics & fiber optics, and mathematical methods in optics. OPTICS-2015 was attended by 100 scientists and students representing 17 countries: Armenia, China, Czech Republic, France, Georgia, Germany, India, Iran, Italy, Latvia, Mexico, Poland, Russia, Saudi Arabia, Sweden, Ukraine, and USA. Such a broad international community confirmed the important mission of science to be a uniting force between different countries, religions, and nations. We hope that OPTICS-2015 inspired and motivated students and young scientists to work in optics and in science in general. The present volume of Journal of Physics: Conference Series includes proceedings of the symposium covering various aspects of modern problems in optics. We are grateful to all people who were involved in the organization process. We gratefully acknowledge support from

  8. 3rd Workshop on Semantic Ambient Media Experience (SAME) - In Conjunction with AmI-2010

    Science.gov (United States)

    Lugmayr, Artur; Stockleben, Bjoern; Kaario, Juha; Pogorelc, Bogdan; Risse, Thomas

    The SAME workshop takes place for the 3rd time in 2010, and it's theme in this year was creating the business value-creation, vision, media theories and technology for ambient media. SAME differs from other workshops due to its interactive and creative touch and going beyond simple powerpoint presentations. Several results will be published by AMEA - the AMbient Media Association (www.ambientmediaassociation.org.

  9. Impressions from the 3rd Nordcode Seminar & Workshop

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Boelskifte, Per; Hansen, Claus Thorp

    2005-01-01

    This paper summarises the purpose and contents of the 3rd Nordcode Seminar and Workshop. First, the workshop assignments are described. Second, the paper briefly presents the topics of the keynote speeches and all presentations of the working papers that took place in the seminar....

  10. 3rd Session of the Sant Cugat Forum on Astrophysics

    CERN Document Server

    Gravitational wave astrophysics

    2015-01-01

    This book offers review chapters written by invited speakers of the 3rd Session of the Sant Cugat Forum on Astrophysics — Gravitational Waves Astrophysics. All chapters have been peer reviewed. The book goes beyond normal conference proceedings in that it provides a wide panorama of the astrophysics of gravitational waves and serves as a reference work for researchers in the field.

  11. 3rd Semester and Master’s Thesis Ideas 2011

    DEFF Research Database (Denmark)

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester p...

  12. 3rd Semester and Master’s Thesis Ideas 2012

    DEFF Research Database (Denmark)

    Clausen, Johan

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester p...

  13. 3rd Semester and Master’s Thesis Ideas 2013

    DEFF Research Database (Denmark)

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd seme...

  14. 3rd International Caricature Art Competition, Beijing, China

    OpenAIRE

    Mumberson, Stephen

    2016-01-01

    One of ten medal winners of the 3rd International Caricature Art Competition, Beijing,China on the theme Dachuan Xia -Chinese Cartoonist,Illustrator and Academic. I was one of only two European artists selected and the only British artist selected. The fellow winners came from Turkey, Egypt, Iran and China. The competition was organized by RedManArt, Beijing,China

  15. Minutes of the 3rd World Integrative Medicine Congress

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ With its mottos of Inheritance,Innovation,Harmonization,and Development,the 3rd World Integrative Medicine Congress has been held in Guangzhou,China from September 22 to 24,2007,sponsored by the Chinese Association of Integrative Medicine and co-organized by Guangdong Provincial Academy of Chinese Medical Sciences.

  16. [The application of CRISPR/Cas9 genome editing technology in cancer research].

    Science.gov (United States)

    Wang, Dayong; Ma, Ning; Hui, Yang; Gao, Xu

    2016-01-01

    The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease) genome editing technology has become more and more popular in gene editing because of its simple design and easy operation. Using the CRISPR/Cas9 system, researchers can perform site-directed genome modification at the base level. Moreover, it has been widely used in genome editing in multiple species and related cancer research. In this review, we summarize the application of the CRISPR/Cas9 system in cancer research based on the latest research progresses as well as our understanding of cancer research and genome editing techniques.

  17. Progress in Genome Editing Technology and Its Application in Plants

    Science.gov (United States)

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, protein-dependent DNA cleavage systems (i.e., zinc-finger nucleases, ZFN, and transcription activator-like effector nucleases, TALEN), RNA-dependent DNA cleavage systems (i.e., clustered regularly interspaced short palindromic repeats-CRISPR associated proteins, CRISPR-Cas9, CRISPR-Cpf1, and CRISPR-C2c1), and RNA-dependent RNA cleavage systems (i.e., RNA interference, RNAi, and CRISPR-C2c2). All these techniques can lead to double-stranded (DSB) or single-stranded breaks (SSB), and result in either random mutations via non-homologous end-joining (NHEJ) or targeted mutation via homologous recombination (HR). Thus, site-directed mutagenesis can be induced via targeted gene knock-out, knock-in, or replacement to modify specific characteristics including morphology-modification, resistance-enhancement, and physiological mechanism-improvement along with plant growth and development. In this paper, an non-comprehensive review on the development of different GETs as applied to plants is presented. PMID:28261237

  18. Progress in Genome Editing Technology and Its Application in Plants.

    Science.gov (United States)

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, protein-dependent DNA cleavage systems (i.e., zinc-finger nucleases, ZFN, and transcription activator-like effector nucleases, TALEN), RNA-dependent DNA cleavage systems (i.e., clustered regularly interspaced short palindromic repeats-CRISPR associated proteins, CRISPR-Cas9, CRISPR-Cpf1, and CRISPR-C2c1), and RNA-dependent RNA cleavage systems (i.e., RNA interference, RNAi, and CRISPR-C2c2). All these techniques can lead to double-stranded (DSB) or single-stranded breaks (SSB), and result in either random mutations via non-homologous end-joining (NHEJ) or targeted mutation via homologous recombination (HR). Thus, site-directed mutagenesis can be induced via targeted gene knock-out, knock-in, or replacement to modify specific characteristics including morphology-modification, resistance-enhancement, and physiological mechanism-improvement along with plant growth and development. In this paper, an non-comprehensive review on the development of different GETs as applied to plants is presented.

  19. JPRS Report, Science and Technology Japan, 3rd Microelectronics Symposium

    Science.gov (United States)

    2007-11-02

    Cu system Alcosink, with characteristics equivalent to those of A1 20 3 , has already been marketed . However, special care is necessary in the...copper film and to improve the adhesion strength of the copper film. The thickness was adjusted to 5 pm by an Ni-P marketed bath (pH 6.5, 70°C). The AlN...ZnS layer was realized by controlling the air valve and shutter with a computer. N,. 4P C’ 0*C Figure 3. Schematic Diagram of Metallo-Organic Molecular

  20. 3rd Active Flow and Combustion Control Conference

    CERN Document Server

    2015-01-01

    The book reports on the latest theoretical and experimental advances in the  field of active flow and combustion control. It covers new developments in actuator technology and sensing, in robust and optimal open- and closed-loop control, as well as in model reduction for control. It collects contributions presented during the third edition of the Active Flow and Combustion Control conference, held in September 10-12, 2014 at the Technische Universität Berlin (Germany). This conference, as well as the research presented in the book, have been supported by the collaborative research center SFB 1029 -Substantial efficiency increase in gas turbines through direct use of coupled unsteady combustion and flow dynamics, funded by the DFG (German Research Foundation).

  1. Organizational Knowledge Communication – a Nascent 3rd Order Disciplinarity

    DEFF Research Database (Denmark)

    Kastberg, Peter

    2014-01-01

    to Organizational Knowledge Communication, i.e., organization studies, communication theory and Knowledge Management, respectively. In their synthesis the three trajectories form a disciplinary triple helix, a triple helix which, in turn, gives rise to Organizational Knowledge Communication as a novel, 3rd order...... visible, becomes a disciplinarity. I theoretically present an example of such a punctual integration and point to some of the immediate research promises that it holds. This theoretical account ends by describing Organizational Knowledge Communication as a nascent 3rd order disciplinarity.......There is an emerging tendency that the organizational communication functions of larger companies enter into a symbiotic relationship with the companies’ Knowledge Management function. A tendency this journal has labelled Organizational Knowledge Communication. This should come as no surprise...

  2. Anatomy and Physiology. Module Set II: Major Body Systems. Teacher Edition [and] Student Edition. Surgical Technology.

    Science.gov (United States)

    Hilley, Robert

    This document, which is the second part of a two-part set of modules on anatomy and physiology for future surgical technicians, contains the teacher and student editions of an introduction to anatomy and physiology that consists of modules on the following body systems: integumentary system; skeletal system; muscular system; nervous system;…

  3. Nice observatory measurements of double stars (3rd series)

    Science.gov (United States)

    Thorel, J.-C.

    2000-12-01

    We present recent measurements of visual double stars made at the Nice Observatory (3rd series). We also report the discovery of a new double star: JCT 4. Moreover we give a more precise position of the double star DOO 35. Table 1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html

  4. 3rd International Multidisciplinary Microscopy and Microanalysis Congress

    CERN Document Server

    Oral, Zehra

    2017-01-01

    The 3rd International Multidisciplinary Microscopy Congress (InterM2015), held from 19 to 23 October 2015, focused on the latest developments concerning applications of microscopy in the biological, physical and chemical sciences at all dimensional scales, advances in instrumentation, techniques in and educational materials on microscopy. These proceedings gather 17 peer-reviewed technical papers submitted by leading academic and research institutions from nine countries and representing some of the most cutting-edge research available.

  5. 3rd grade English language learners making sense of sound

    OpenAIRE

    Suarez, Enrique; Otero, Valerie

    2012-01-01

    Despite the extensive body of research that supports scientific inquiry and argumentation as cornerstones of physics learning, these strategies continue to be virtually absent in most classrooms, especially those that involve students who are learning English as a second language. This study presents results from an investigation of 3rd grade students' discourse about how length and tension affect the sound produced by a string. These students came from a variety of language backgrounds, and ...

  6. Strategies of Qualitative Inquiry. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  7. 3rd Workshop on "Combinations of Intelligent Methods and Applications"

    CERN Document Server

    Palade, Vasile

    2013-01-01

    The combination of different intelligent methods is a very active research area in Artificial Intelligence (AI). The aim is to create integrated or hybrid methods that benefit from each of their components.  The 3rd Workshop on “Combinations of Intelligent Methods and Applications” (CIMA 2012) was intended to become a forum for exchanging experience and ideas among researchers and practitioners who are dealing with combining intelligent methods either based on first principles or in the context of specific applications. CIMA 2012 was held in conjunction with the 22nd European Conference on Artificial Intelligence (ECAI 2012).This volume includes revised versions of the papers presented at CIMA 2012.  .

  8. 3rd International Conference on Movement, Health and Exercise 2016

    CERN Document Server

    Cheong, Jadeera; Usman, Juliana; Ahmad, Mohd; Razman, Rizal; Selvanayagam, Victor

    2017-01-01

    This volume presents the proceedings of the 3rd International Conference on Movement, Health and Exercise 2016 (MoHE2016). The conference was jointly organized by the Biomedical Engineering Department and Sports Centre, University of Malaya. It was held in Malacca, from 28-30 September 2016. MoHE 2016 provided a good opportunity for speakers and participants to actively discuss about recent developments in a wide range of topics in the area of sports and exercise science. In total, 83 presenters and 140 participants took part in this successful conference. .

  9. Preface to Special Topic: Invited Papers of the 3rd International Conference on Ultrafast Structural Dynamics.

    Science.gov (United States)

    Johnson, S L

    2016-03-01

    The ability to visualize the real-time dynamics of atomic, magnetic, and electronic structure is widely recognized in many fields as a key element underpinning many important processes in chemistry, materials science, and biology. The need for an improved understanding of such processes becomes acute as energy conversion processes on fast time scales become increasingly relevant to problems in science and technology. This special issue, containing invited papers from participants at the 3rd International Conference on Ultrafast Structural Dynamics held June 10-12, 2015 in Zurich, Switzerland, discusses several recent developments in this area.

  10. Preface to Special Topic: Invited Papers of the 3rd International Conference on Ultrafast Structural Dynamics

    Directory of Open Access Journals (Sweden)

    S. L. Johnson

    2016-03-01

    Full Text Available The ability to visualize the real-time dynamics of atomic, magnetic, and electronic structure is widely recognized in many fields as a key element underpinning many important processes in chemistry, materials science, and biology. The need for an improved understanding of such processes becomes acute as energy conversion processes on fast time scales become increasingly relevant to problems in science and technology. This special issue, containing invited papers from participants at the 3rd International Conference on Ultrafast Structural Dynamics held June 10–12, 2015 in Zurich, Switzerland, discusses several recent developments in this area.

  11. 3rd International Conference on X-ray Technique

    Science.gov (United States)

    Potrakhov, N. N.; Gryaznov, A. Yu; Lisenkov, A. A.; Kostrin, D. K.

    2017-02-01

    In this preface a brief history, modern aspects and future tendencies in development of the X-ray technique as seen from the 3rd International Conference on X-ray Technique that was held on 24-25 November 2016 in Saint Petersburg, Russia are described On 24-25 November 2016 in Saint Petersburg on the basis of Saint Petersburg State Electrotechnical University “LETI” n. a. V. I. Ulyanov (Lenin) was held the 3rd International Conference on X-ray Technique. The tradition to hold a similar conference in our country was laid in Soviet times. The last of them, the All-Union Conference on the Prospects of X-ray Tubes and Equipment was organized and held more than a quarter century ago - on 21-23 November 1999, at the initiative and under the leadership of the chief engineer of the Leningrad association of electronic industry “Svetlana” Borovsky Alexander Ivanovich and the chief of special design bureau of X-ray devices of “Svetlana” Shchukin Gennady Anatolievich. The most active part in the organization and work of the conference played members of the department of X-ray and electron beam instruments of Leningrad Electrotechnical Institute “LETI” (the former name of Saint Petersburg State Electrotechnical University “LETI”), represented by head of the department professor Ivanov Stanislav Alekseevich.

  12. Microstructure Modeling of 3rd Generation Disk Alloys

    Science.gov (United States)

    Jou, Herng-Jeng

    2010-01-01

    The objective of this program is to model, validate, and predict the precipitation microstructure evolution, using PrecipiCalc (QuesTek Innovations LLC) software, for 3rd generation Ni-based gas turbine disc superalloys during processing and service, with a set of logical and consistent experiments and characterizations. Furthermore, within this program, the originally research-oriented microstructure simulation tool will be further improved and implemented to be a useful and user-friendly engineering tool. In this report, the key accomplishment achieved during the second year (2008) of the program is summarized. The activities of this year include final selection of multicomponent thermodynamics and mobility databases, precipitate surface energy determination from nucleation experiment, multiscale comparison of predicted versus measured intragrain precipitation microstructure in quench samples showing good agreement, isothermal coarsening experiment and interaction of grain boundary and intergrain precipitates, primary microstructure of subsolvus treatment, and finally the software implementation plan for the third year of the project. In the following year, the calibrated models and simulation tools will be validated against an independently developed experimental data set, with actual disc heat treatment process conditions. Furthermore, software integration and implementation will be developed to provide material engineers valuable information in order to optimize the processing of the 3rd generation gas turbine disc alloys.

  13. Designing a 3rd generation, authenticatable attribute measurement system

    Energy Technology Data Exchange (ETDEWEB)

    Thron, Jonathan [Los Alamos National Laboratory; Karpius, Peter [Los Alamos National Laboratory; Santi, Peter [Los Alamos National Laboratory; Smith, Morag [Los Alamos National Laboratory; Vo, Duc [Los Alamos National Laboratory; Williams, Richard [Los Alamos National Laboratory

    2009-01-01

    Attribute measurement systems (AMS) are designed to measure potentially sensitive items containing Special Nuclear Materials to determine if the items possess attributes which fall within an agreed-upon range. Such systems could be used in a treaty to inspect and verify the identity of items in storage without revealing any sensitive information associated with the item. An AMS needs to satisfy two constraints: the host party needs to be sure that none of their sensitive information is released, while the inspecting party wants to have confidence that the limited amount of information they see accurately reflects the properties of the item being measured. The former involves 'certifying' the system and the latter 'authenticating' it. Previous work into designing and building AMS systems have focused more on the questions of certifiability than on the questions of authentication - although a few approaches have been investigated. The next step is to build a 3rd generation AMS which (1) makes the appropriate measurements, (2) can be certified, and (3) can be authenticated (the three generations). This paper will discuss the ideas, options, and process of producing a design for a 3rd generation AMS.

  14. Newer Gene Editing Technologies toward HIV Gene Therapy

    OpenAIRE

    2013-01-01

    Despite the great success of highly active antiretroviral therapy (HAART) in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called “Berlin patient” who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realist...

  15. Key Success Factors of 3rd Generation Mobile Network Services for M-Commerce in Malaysia

    Directory of Open Access Journals (Sweden)

    Saravanan Muthaiyah

    2004-01-01

    Full Text Available While there has been a great deal of excitement in view of M-commerce, very little is actually known about conditions and critical success factors for successful introduction of the 3rd generation mobile network services here in Malaysia. This study investigates the factors for successful diffusion of 3G network services and their role in advancing an interactive marketplace. 3G which simply means 3rd generation mobile communications technology has been widely discussed by many telecommunications service providers. It was launched by the International Telecommunication Union (ITU some 13 years ago. 3G is viewed as an enabler of M-Commerce here in Malaysia. However, true success of this technology depends on various factors. The objective of this study is to investigate significant key enablers of 3G deployment and adoption in Malaysia. An insight into the critical factors to be considered for the deployment of 3G technology in Malaysia and experiences of other countries will be used as a benchmark to understand the mitigating factors of 3G deployment. Critical factors such as cost to of service, interoperability of standards, insufficiency of mobile services or content and deficiency of the laws will be discussed in this study. The study also discusses diffusion barriers and drivers for the rapid service diffusion of 3G mobile networks.

  16. Application of genome editing technologies to the study and treatment of hematological disease.

    Science.gov (United States)

    Pellagatti, Andrea; Dolatshad, Hamid; Yip, Bon Ham; Valletta, Simona; Boultwood, Jacqueline

    2016-01-01

    Genome editing technologies have advanced significantly over the past few years, providing a fast and effective tool to precisely manipulate the genome at specific locations. The three commonly used genome editing technologies are Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Cas9 (CRISPR/Cas9) system. ZFNs and TALENs consist of endonucleases fused to a DNA-binding domain, while the CRISPR/Cas9 system uses guide RNAs to target the bacterial Cas9 endonuclease to the desired genomic location. The double-strand breaks made by these endonucleases are repaired in the cells either by non-homologous end joining, resulting in the introduction of insertions/deletions, or, if a repair template is provided, by homology directed repair. The ZFNs, TALENs and CRISPR/Cas9 systems take advantage of these repair mechanisms for targeted genome modification and have been successfully used to manipulate the genome in human cells. These genome editing tools can be used to investigate gene function, to discover new therapeutic targets, and to develop disease models. Moreover, these genome editing technologies have great potential in gene therapy. Here, we review the latest advances in the application of genome editing technology to the study and treatment of hematological disorders.

  17. PREFACE: 3rd International Conference of Mechanical Engineering Research (ICMER 2015)

    Science.gov (United States)

    Mamat, Riazalman; Rahman, Mustafizur; Mohd. Zuki Nik Mohamed, Nik; Che Ghani, Saiful Anwar; Harun, Wan Sharuzi Wan

    2015-12-01

    The 3rd ICMER2015 is the continuity of the NCMER2010. The year 2010 represents a significant milestone in the history for Faculty of Mechanical Engineering, Universiti Malaysia Pahang (UMP) Malaysia with the organization of the first and second national level conferences (1st and 2nd NCMER) at UMP on May 26-27 and Dec 3-4 2010. The Faculty then changed the name from National Conference on Mechanical Engineering Research (NCMER) to International Conference on Mechanical Engineering Research (ICMER) in 2011 and this year, 2015 is our 3rd ICMER. These proceedings contain the selected scientific manuscripts submitted to the conference. It is with great pleasure to welcome you to the "International Conference on Mechanical Engineering Research (ICMER2015)" that is held at Zenith Hotel, Kuantan, Malaysia. The call for papers attracted submissions of over two hundred abstracts from twelve different countries including Japan, Iran, China, Kuwait, Indonesia, Norway, Philippines, Morocco, Germany, UAE and more. The scientific papers published in these proceedings have been revised and approved by the technical committee of the 3rd ICMER2015. All of the papers exhibit clear, concise, and precise expositions that appeal to a broad international readership interested in mechanical engineering, combustion, metallurgy, materials science as well as in manufacturing and biomechanics. The reports present original ideas or results of general significance supported by clear reasoning and compelling evidence, and employ methods, theories and practices relevant to the research. The authors clearly state the questions and the significance of their research to theory and practice, describe how the research contributes to new knowledge, and provide tables and figures that meaningfully add to the narrative. In this edition of ICMER representatives attending are from academia, industry, governmental and private sectors. The plenary and invited speakers will present, discuss, promote and

  18. PREFACE: 3rd Workshop on Theory, Modelling and Computational Methods for Semiconductors (TMCSIII)

    Science.gov (United States)

    Califano, Marco; Migliorato, Max; Probert, Matt

    2012-05-01

    These conference proceedings contain the written papers of the contributions presented at the 3rd International Conference on Theory, Modelling and Computational Methods for Semiconductor materials and nanostructures. The conference was held at the School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK on 18-20 January 2012. The previous conferences in this series took place in 2010 at St William's College, York and in 2008 at the University of Manchester, UK. The development of high-speed computer architectures is finally allowing the routine use of accurate methods for calculating the structural, thermodynamic, vibrational, optical and electronic properties of semiconductors and their hetero- and nano-structures. The scope of this conference embraces modelling, theory and the use of sophisticated computational tools in semiconductor science and technology, where there is substantial potential for time-saving in R&D. Theoretical approaches represented in this meeting included: Density Functional Theory, Tight Binding, Semiempirical Pseudopotential Methods, Effective Mass Models, Empirical Potential Methods and Multiscale Approaches. Topics included, but were not limited to: Optical and Transport Properties of Quantum Nanostructures including Colloids and Nanotubes, Plasmonics, Magnetic Semiconductors, Graphene, Lasers, Photonic Structures, Photovoltaic and Electronic Devices. This workshop ran for three days, with the objective of bringing together UK and international leading experts in the theoretical modelling of Group IV, III-V and II-VI semiconductors, as well as students, postdocs and early-career researchers. The first day focused on providing an introduction and overview of this vast field, aimed particularly at students, with several lectures given by recognised experts in various theoretical approaches. The following two days showcased some of the best theoretical research carried out in the UK in this field, with several

  19. 3rd Workshop on Branching Processes and their Applications

    CERN Document Server

    González, Miguel; Gutiérrez, Cristina; Martínez, Rodrigo; Minuesa, Carmen; Molina, Manuel; Mota, Manuel; Ramos, Alfonso; WBPA15

    2016-01-01

    This volume gathers papers originally presented at the 3rd Workshop on Branching Processes and their Applications (WBPA15), which was held from 7 to 10 April 2015 in Badajoz, Spain (http://branching.unex.es/wbpa15/index.htm). The papers address a broad range of theoretical and practical aspects of branching process theory. Further, they amply demonstrate that the theoretical research in this area remains vital and topical, as well as the relevance of branching concepts in the development of theoretical approaches to solving new problems in applied fields such as Epidemiology, Biology, Genetics, and, of course, Population Dynamics. The topics covered can broadly be classified into the following areas: 1. Coalescent Branching Processes 2. Branching Random Walks 3. Population Growth Models in Varying and Random Environments 4. Size/Density/Resource-Dependent Branching Models 5. Age-Dependent Branching Models 6. Special Branching Models 7. Applications in Epidemiology 8. Applications in Biology and Genetics Offer...

  20. Report from the 3rd Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2010-02-01

    Full Text Available Academic and industrial users are increasingly facing the challenge of petabytes of data, but managing and analyzing such large data sets still remains a daunting task. Both the database and the map/reduce communities worldwide are working on addressing these issues. The 3rdExtremely Large Databases workshop was organized to examine the needs of scientific communities beginning to face these issues, to reach out to European communities working on extremely large scale data challenges, and to brainstorm possible solutions. The science benchmark that emerged from the 2nd workshop in this series was also debated. This paper is the final report of the discussions and activities at this workshop.

  1. 3rd grade English language learners making sense of sound

    Science.gov (United States)

    Suarez, Enrique; Otero, Valerie

    2013-01-01

    Despite the extensive body of research that supports scientific inquiry and argumentation as cornerstones of physics learning, these strategies continue to be virtually absent in most classrooms, especially those that involve students who are learning English as a second language. This study presents results from an investigation of 3rd grade students' discourse about how length and tension affect the sound produced by a string. These students came from a variety of language backgrounds, and all were learning English as a second language. Our results demonstrate varying levels, and uses, of experiential, imaginative, and mechanistic reasoning strategies. Using specific examples from students' discourse, we will demonstrate some of the productive aspects of working within multiple language frameworks for making sense of physics. Conjectures will be made about how to utilize physics as a context for English Language Learners to further conceptual understanding, while developing their competence in the English language.

  2. 3rd grade English language learners making sense of sound

    CERN Document Server

    Suarez, Enrique

    2012-01-01

    Despite the extensive body of research that supports scientific inquiry and argumentation as cornerstones of physics learning, these strategies continue to be virtually absent in most classrooms, especially those that involve students who are learning English as a second language. This study presents results from an investigation of 3rd grade students' discourse about how length and tension affect the sound produced by a string. These students came from a variety of language backgrounds, and all were learning English as a second language. Our results demonstrate varying levels, and uses, of experiential, imaginative, and mechanistic reasoning strategies. Using specific examples from students' discourse, we will demonstrate some of the productive aspects of working within multiple language frameworks for making sense of physics. Conjectures will be made about how to utilize physics as a context for English Language Learners to further conceptual understanding, while developing their competence in the English l...

  3. 3rd Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2014-01-01

    This book is based on the research papers presented in the 3rd Computer Science On-line Conference 2014 (CSOC 2014).   The conference is intended to provide an international forum for discussions on the latest high-quality research results in all areas related to Computer Science. The topics addressed are the theoretical aspects and applications of Artificial Intelligences, Computer Science, Informatics and Software Engineering.   The authors provide new approaches and methods to real-world problems, and in particular, exploratory research that describes novel approaches in their field. Particular emphasis is laid on modern trends in selected fields of interest. New algorithms or methods in a variety of fields are also presented.   This book is divided into three sections and covers topics including Artificial Intelligence, Computer Science and Software Engineering. Each section consists of new theoretical contributions and applications which can be used for the further development of knowledge of everybod...

  4. 3rd International Workshop on Turbulent Spray Combustion

    CERN Document Server

    Gutheil, Eva

    2014-01-01

    This book reflects the results of the 2nd and 3rd International Workshops on Turbulent Spray Combustion. The focus is on progress in experiments and numerical simulations for two-phase flows, with emphasis on spray combustion. Knowledge of the dominant phenomena and their interactions allows development of predictive models and their use in combustor and gas turbine design. Experts and young researchers present the state-of-the-art results, report on the latest developments and exchange ideas in the areas of experiments, modelling and simulation of reactive multiphase flows. The first chapter reflects on flame structure, auto-ignition and atomization with reference to well-characterized burners, to be implemented by modellers with relative ease. The second chapter presents an overview of first simulation results on target test cases, developed at the occasion of the 1st International Workshop on Turbulent Spray Combustion. In the third chapter, evaporation rate modelling aspects are covered, while the fourth ...

  5. 3rd International Symposium for Intelligent Transportation and Smart City

    CERN Document Server

    Xie, Xiongyao; Sun, Jian; Ma, Limin; Chen, Yinong; ITASC

    2017-01-01

    This book presents research advances in intelligent transportation and smart cities in detail, mainly focusing on green traffic and urban utility tunnels, presented at the 3rd International Symposium for Intelligent Transportation and Smart City (ITASC) held at Tongji University, Shanghai, on May 19–20, 2017. It discusses a number of hot topics, such as the 2BMW system (Bus, Bike, Metro and Walking), transportation safety and environmental protection, urban utility design and application, as well as the application of BIM (Building Information Modeling) in city design. By connecting the theory and applications of intelligent transportation in smart cities, it enhances traffic efficiency and quality. The book gathers numerous selected papers and lectures, including contributions from respected scholars and the latest engineering advances, to provide guidance to researchers in the field of transportation and urban planning at universities and in related industries. The first conference in the ITASC series sta...

  6. Delivery and therapeutic applications of gene editing technologies ZFNs, TALENs, and CRISPR/Cas9.

    Science.gov (United States)

    LaFountaine, Justin S; Fathe, Kristin; Smyth, Hugh D C

    2015-10-15

    In recent years, several new genome editing technologies have been developed. Of these the zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 RNA-guided endonuclease system are the most widely described. Each of these technologies utilizes restriction enzymes to introduce a DNA double stranded break at a targeted location with the guide of homologous binding proteins or RNA. Such targeting is viewed as a significant advancement compared to current gene therapy methods that lack such specificity. Proof-of-concept studies have been performed to treat multiple disorders, including in vivo experiments in mammals and even early phase human trials. Careful consideration and investigation of delivery strategies will be required so that the therapeutic potential for gene editing is achieved. In this review, the mechanisms of each of these gene editing technologies and evidence of therapeutic potential will be briefly described and a comprehensive list of past studies will be provided. The pharmaceutical approaches of each of these technologies are discussed along with the current delivery obstacles. The topics and information reviewed herein provide an outline of the groundbreaking research that is being performed, but also highlights the potential for progress yet to be made using these gene editing technologies.

  7. The CRISPR-Cas9 technology: Closer to the ultimate toolkit for targeted genome editing.

    Science.gov (United States)

    Quétier, Francis

    2016-01-01

    The first period of plant genome editing was based on Agrobacterium; chemical mutagenesis by EMS (ethyl methanesulfonate) and ionizing radiations; each of these technologies led to randomly distributed genome modifications. The second period is associated with the discoveries of homing and meganuclease enzymes during the 80s and 90s, which were then engineered to provide efficient tools for targeted editing. From 2006 to 2012, a few crop plants were successfully and precisely modified using zinc-finger nucleases. A third wave of improvement in genome editing, which led to a dramatic decrease in off-target events, was achieved in 2009-2011 with the TALEN technology. The latest revolution surfaced in 2013 with the CRISPR-Cas9 system, whose high efficiency and technical ease of use is really impressive; scientists can use in-house kits or commercially available kits; the only two requirements are to carefully choose the location of the DNA double strand breaks to be induced and then to order an oligonucleotide. While this close-to- ultimate toolkit for targeted editing of genomes represents dramatic scientific progress which allows the development of more complex useful agronomic traits through synthetic biology, the social acceptance of genome editing remains regularly questioned by anti-GMO citizens and organizations.

  8. Integrate Web 2.0 Technology to Facilitate Online Professional Community: EMI Special Editing Experiences

    Science.gov (United States)

    Tu, Chih-Hsiung; Blocher, Michael; Ntoruru, Joshua

    2008-01-01

    This article reports on the collaborative journal review of an online professional community that was established to prepare this special edition for publication. The focus is on how Web 2.0 technology can be used to support a professional journal review community and to enhance active social interaction among reviewers. The theme of this special…

  9. Investigation and Analysis on the Dynamic Characteristics of the Core Journals of Science and Technology in China%我国科技核心期刊动态性调查与分析

    Institute of Scientific and Technical Information of China (English)

    何荣利; 李戈

    2001-01-01

    Based on the 2nd and 3rd editions of A Guide to Core Journals of China, this article makes an investigation on the change of the number, the variety and the ranking of the core journals of science and technology which are on the same subject. The basic dynamic characteristics of the core journals of science and technology in China are described.

  10. The Third International Genomic Medicine Conference (3rd IGMC, 2015: overall activities and outcome highlights

    Directory of Open Access Journals (Sweden)

    Muhammad Abu-Elmagd

    2016-10-01

    Full Text Available Abstract The Third International Genomic Medicine Conference (3rd IGMC was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA. This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1st IGMC, 2011 followed by the second International Genomic Medicine Conference (2nd IGMC, 2013. The 3rd IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.

  11. The Third International Genomic Medicine Conference (3rd IGMC, 2015): overall activities and outcome highlights.

    Science.gov (United States)

    Abu-Elmagd, Muhammad; Assidi, Mourad; Dallol, Ashraf; Buhmeida, Abdelbaset; Pushparaj, Peter Natesan; Kalamegam, Gauthaman; Al-Hamzi, Emad; Shay, Jerry W; Scherer, Stephen W; Agarwal, Ashok; Budowle, Bruce; Gari, Mamdooh; Chaudhary, Adeel; Abuzenadah, Adel; Al-Qahtani, Mohammed

    2016-10-17

    The Third International Genomic Medicine Conference (3(rd) IGMC) was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR) at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA). This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1(st) IGMC, 2011) followed by the second International Genomic Medicine Conference (2(nd) IGMC, 2013). The 3(rd) IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.

  12. [Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities].

    Science.gov (United States)

    Xiangyu, Fan; Yanping, Lin; Guojian, Liao; Jianping, Xie

    2015-12-01

    Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.

  13. 3rd Course of the International School of Advanced Geodesy

    CERN Document Server

    Sansò, Fernando

    1985-01-01

    During the period April 25th to May 10th, 1984 the 3rd Course of the International School of Advanced Geodesy entitled "Optimization and Design of Geodetic Networks" took place in Erice. The main subject of the course is clear from the title and consisted mainly of that particular branch of network analysis, which results from applying general concepts of mathematical optimization to the design of geodetic networks. As al­ ways when dealing with optimization problems, there is an a-priori choice of the risk (or gain) function which should be minimized (or maximized) according to the specific interest of the "designer", which might be either of a scientific or of an economic nature or even of both. These aspects have been reviewed in an intro­ ductory lecture in which the particular needs arising in a geodetic context and their analytical representations are examined. Subsequently the main body of the optimization problem, which has been conven­ tionally divided into zero, first, second and third order desi...

  14. The 3rd irradiation test plan of DUPIC fuel

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Myung Seung; Song, K. C.; Park, J. H. and others

    2001-05-01

    The objective of the 3rd irradiation test of DUPIC fuel at the HANARO is to estimate the in-core behaviour of a DUPIC pellet that is irradiated up to more than average burnup of CANDU fuel. The irradiation of DUPIC fuel is planned to start at May 21, 2001, and will be continued at least for 8 months. The burnup of DUPIC fuel through this irradiation test is thought to be more than 7,000 MWd/tHE. The DUPIC irradiation rig instrumented with three SPN detectors will be used to accumulate the experience for the instrumented irradiation and to estimate the burnup of irradiated DUPIC fuel more accurately. Under normal operating condition, the maximum linear power of DUPIC fuel was estimated as 55.06 kW/m, and the centerline temperature of a pellet was calculated as 2510 deg C. In order to assess the integrity of DUPIC fuel under the accident condition postulated at the HANARO, safety analyses on the locked rotor and reactivity insertion accidents were carried out. The maximum centerline temperature of DUPIC fuel was estimated 2590 deg C and 2094 deg C for each accident, respectively. From the results of the safety analysis, the integrity of DUPIC fuel during the HANARO irradiation test will be secured. The irradiated DUPIC fuel will be transported to the IMEF. The post-irradiation examinations are planned to be performed at the PIEF and IMEF.

  15. Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy.

    Science.gov (United States)

    Gori, Jennifer L; Hsu, Patrick D; Maeder, Morgan L; Shen, Shen; Welstead, G Grant; Bumcrot, David

    2015-07-01

    Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated 9 (Cas9) technology is revolutionizing the study of gene function and likely will give rise to an entire new class of therapeutics for a wide range of diseases. Achieving this goal requires not only characterization of the technology for efficacy and specificity but also optimization of its delivery to the target cells for each disease indication. In this review we survey the various methods by which the CRISPR-Cas9 components have been delivered to cells and highlight some of the more clinically relevant approaches. Additionally, we discuss the methods available for assessing the specificity of Cas9 editing; an important safety consideration for development of the technology.

  16. Robotics-Control Technology. Technology Learning Activity. Teacher Edition. Technology Education Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the materials required for presenting an 8-day competency-based technology learning activity (TLA) designed to introduce students in grades 6-10 to advances and career opportunities in the field of robotics-control technology. The guide uses hands-on exploratory experiences into which activities to help students develop…

  17. 3rd Joint Dutch-Brazil School on Theoretical Physics

    CERN Document Server

    2015-01-01

    The Joint Dutch-Brazil School on Theoretical Physics is now in its third edition with previous schools in 2007 and 2011. This edition of the school will feature minicourses by Nima Arkani-Hamed (IAS Princeton), Jan de Boer (University of Amsterdam) and Cumrun Vafa (Harvard University), as well as student presentations. The school is jointly organized with the Dutch Research School of Theoretical Physics (DRSTP) and is intended for graduate students and researchers in the field of high-energy theoretical physics. There is no registration fee and limited funds are available for local and travel support of participants. This school in São Paulo will be preceded by the XVIII J. A. Swieca School in Campos de Jordão.

  18. Frisbee - the first artificial cervical disc of 3RD generation

    Directory of Open Access Journals (Sweden)

    Karin Büttner-Janz

    2014-03-01

    Full Text Available OBJECTIVE: The current cervical disc arthroplasty is limited by postoperative facet joint arthritis, heterotopic ossification and segmental kyphosis. The total Frisbee disc, which has an upper convex/concave non-spherical surface and a lower flat sliding surface, is a new approach for improved outcomes. Prior to clinical application, safety and suitability tests are required. METHODS: The Frisbee is the first 3rd generation disc according to a new classification of total disc because it can precisely mimic the segmental ROM, including the soft limitation of axial rotation. The ISO 18192-1 test was carried out to determine the rate of wear debris. A FE model was used to assess the safety of prosthetic components. In the sagittal plane several variables to determine the most favorable lordotic angle were evaluated. RESULTS: Two angled prosthetic plates are safer than one sliding angled core to prevent the displacement. The lordosis of 7° of the Frisbee leads to kyphosis of no more than 2° without reduction of the ROM. The wear rate of the Frisbee is five times smaller compared to an FDA-approved disc with a spherical sliding surface. CONCLUSIONS: Based on the test results, the clinical application of Frisbee can now be studied. The postoperative kyphosis observed with other devices is not an issue with the Frisbee design. Physiological ROM is combined with the significant reduction of wear debris. For these reasons the Frisbee has the potential to provide a better balanced segmental loading reducing the degeneration of the joint surface and heterotopic ossification.

  19. Bifurcation of limit cycles in 3rd-order Z2 Hamiltonian planar vector fields with 3rd-order perturbations

    Science.gov (United States)

    Yu, Pei; Han, Maoan

    2013-04-01

    In this paper, we show that a Z2-equivariant 3rd-order Hamiltonian planar vector fields with 3rd-order symmetric perturbations can have at least 10 limit cycles. The method combines the general perturbation to the vector field and the perturbation to the Hamiltonian function. The Melnikov function is evaluated near the center of vector field, as well as near homoclinic and heteroclinic orbits.

  20. 3rd International Doctoral Symposium on Applied Computation and Security Systems

    CERN Document Server

    Saeed, Khalid; Cortesi, Agostino; Chaki, Nabendu

    2017-01-01

    This book presents extended versions of papers originally presented and discussed at the 3rd International Doctoral Symposium on Applied Computation and Security Systems (ACSS 2016) held from August 12 to 14, 2016 in Kolkata, India. The symposium was jointly organized by the AGH University of Science & Technology, Cracow, Poland; Ca’ Foscari University, Venice, Italy; and the University of Calcutta, India. The book is divided into two volumes, Volumes 3 and 4, and presents dissertation works in the areas of Image Processing, Biometrics-based Authentication, Soft Computing, Data Mining, Next-Generation Networking and Network Security, Remote Healthcare, Communications, Embedded Systems, Software Engineering and Service Engineering. The first two volumes of the book published the works presented at the ACSS 2015, which was held from May 23 to 25, 2015 in Kolkata, India.

  1. 3rd International Asia Conference on Informatics in Control, Automation and Robotics

    CERN Document Server

    Informatics in Control, Automation and Robotics

    2012-01-01

    Session 2 includes 110 papers selected from 2011 3rd International Asia Conference on Informatics in Control, Automation and Robotics (CAR 2011), held on December 24-25, 2011, Shenzhen, China.   As we all know, the ever growing technology in robotics and automation will help build a better human society. This session will provide a unique opportunity for the academic and industrial communities to address new challenges, share solutions, and discuss research directions for the future. Robotics research emphasizes intelligence and adaptability to cope with unstructured environments. Automation research emphasizes efficiency, productivity, quality, and reliability, focusing on systems that operate autonomously. The main focus of this session is on the autonomous acquisition of semantic information in intelligent robots and systems, as well as the use of semantic knowledge to guide further acquisition of information.

  2. 3rd international KES conference on Smart Education and Smart e-Learning

    CERN Document Server

    Howlett, Robert; Jain, Lakhmi

    2016-01-01

    This book contains the contributions presented at the 3rd international KES conference on Smart Education and Smart e-Learning, which took place in Puerto de la Cruz, Tenerife, Spain, June 15-17, 2016. It contains a total of 56 peer-reviewed book chapters that are grouped into several parts: Part 1 - Smart University: Conceptual Modeling, Part 2 – Smart Education: Research and Case Studies, Part 3 – Smart e-Learning, Part 4 – Smart Education: Software and Hardware Systems, and Part 5 – Smart Technology as a Resource to Improve Education and Professional Training. We believe that the book will serve as a useful source of research data and valuable information for faculty, scholars, Ph.D. students, administrators, and practitioners - those who are interested in innovative areas of smart education and smart e-learning. .

  3. Application of CRISPR technology in genome editing in agriculture -swine

    Science.gov (United States)

    Decades of selective breeding in agricultural species has led to the derivation of stronger and fitter animals with improved production traits. However, often co-segregating with beneficial traits are less desirable traits. With the plethora of genome data and annotation, has come the technology t...

  4. ASPHALT FOR OFF-STREET PAVING AND PLAY AREAS, 3RD EDITION.

    Science.gov (United States)

    Asphalt Inst., College Park, MD.

    THIS PAMPHLET DISCUSSES THE ALTERNATIVE METHODS, APPLICATIONS, AND TECHNICAL CONSIDERATIONS FOR OFF-STREET PAVING AND PLAY AREAS. OFF-STREET PAVING INCLUDES--(1) ASPHALT-PAVED PARKING AREAS, (2) ROOF DECK PARKING AREAS, (3) ASPHALT-PAVED DRIVEWAYS, (4) ASPHALT-PAVED SERVICE STATION LOTS, AND (5) SIDEWALKS. THE DISCUSSION OF PLAY AREAS…

  5. Kids at Hope: Every Child Can Succeed, No Exceptions! 3rd Edition

    Science.gov (United States)

    Carlos, John P.; Miller, Rick

    2010-01-01

    "Kids at Hope" inspires, empowers, and transforms families, youth serving organizations and entire communities to create an environment where all children experience success. This book contains the following chapters: (1) The Visit Universal Truths I & II; (2) The Classroom (A Celebration of Success); (3) What Makes a Difference?; (4) No…

  6. An introduction to Kolmogorov complexity and its applications. - 3rd edition

    NARCIS (Netherlands)

    Li, M.; Vitányi, P.

    2008-01-01

    Written by two experts in the field, this book is ideal for advanced undergraduate students, graduate students, and researchers in all fields of science. It is self-contained: it contains the basic requirements from mathematics, probability theory, statistics, information theory, and computer scienc

  7. An introduction to Kolmogorov complexity and its applications. - 3rd edition

    NARCIS (Netherlands)

    Li, M.; Vitányi, P.

    2008-01-01

    Written by two experts in the field, this book is ideal for advanced undergraduate students, graduate students, and researchers in all fields of science. It is self-contained: it contains the basic requirements from mathematics, probability theory, statistics, information theory, and computer

  8. SCHOOL LIGHTING APPLICATION DATA. EXCERPTS FROM THE IES LIGHTING HANDBOOK, 3RD EDITION.

    Science.gov (United States)

    Illuminating Engineering Society, New York, NY.

    THIS PUBLICATION REGARDING SCHOOL LIGHTING WAS PREPARED AS A USEFUL ADDITION TO THE AMERICAN STANDARD GUIDE FOR SCHOOL LIGHTING. THE MATERIAL HAS BEEN EXTRACTED FROM THE IES LIGHTING HANDBOOK TO INCLUDE A MORE DETAILED TREATMENT OF SUBJECTS TO WHICH THE DESIGNER MUST GIVE IMPORTANT CONSIDERATION. THERE IS A MORE EXTENSIVE TREATMENT OF REFLECTED…

  9. Honors Programs at Smaller Colleges. 3rd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Schuman, Samuel

    2011-01-01

    This monograph focuses upon areas of special concern to those working with honors at smaller colleges and universities: mission, recruitment, facilities, administration, budget, and curriculum. In each area, the author makes some general suggestions about overall operating principles, note specific issues that can lead to difficulties, and suggest…

  10. Andrology 3rd edition- E. Nieschlag, H.M. Behre, S. Nieschlag (eds)

    Institute of Scientific and Technical Information of China (English)

    Andreas Meinhardt

    2010-01-01

    @@ Andrology is a young and emerging discipline whose growing eminence was recently acknowledged in Germany where it attained the stature of a clinical subspecialty. This recognition, in turn, has acted as a catalyst for the re-examination and reclassification of the discipline in many countries.

  11. Teaching Elementary Mathematics: A Resource for Field Experiences. 3rd Edition

    Science.gov (United States)

    Smith, Nancy L.

    2006-01-01

    This book is a hands-on field manual for elementary school teachers. It features a range of activities that offer opportunities for reflection while enhancing student field experiences, through observation and practicum. The first section of the book provides activities that focus on collecting information about the school and its resources, and…

  12. Craftsman/NSTA Young Inventors Awards Program Teacher's Guide. 3rd Edition.

    Science.gov (United States)

    Frankovits, Nick; Luton, L. Grant; Evans, Gay

    This guide introduces the Craftsman/NSTA Young Inventors Award Program and includes information on competitions, science activities, and tips on how to facilitate invention programs. Sections include the following: (1) "Introducing the Craftsman/NSTA Young Inventors Awards Program"; (2) "Teaching Invention"; (3) "Young…

  13. An introduction to Kolmogorov complexity and its applications. - 3rd edition

    NARCIS (Netherlands)

    Li, M.; Vitányi, P.

    2008-01-01

    Written by two experts in the field, this book is ideal for advanced undergraduate students, graduate students, and researchers in all fields of science. It is self-contained: it contains the basic requirements from mathematics, probability theory, statistics, information theory, and computer scienc

  14. Resources Related to Children and Their Families Affected by Alcohol and Other Drugs. 3rd Edition.

    Science.gov (United States)

    Melner, Joan; Shackelford, Jo; Hargrove, Elisabeth; Daulton, Deb

    This document identifies resources that serve young children and their families affected by alcohol and other drug use. The resources are organized into three sections: National Training and Information Resources, State Programs and Agencies, and Federal Funding Sources. Information on locating grant funds from federal agencies, private…

  15. MOPAC Manual: A General Molecular Orbital Package. 3rd Edition, 2nd Version

    Science.gov (United States)

    1986-06-01

    NLLSQ DCART - PRINT DETAILS OF WORKING IN DCART DEBUG - DEBUG OPTION TURNED ON DEBUGPULAY PRINT DETAILS OF WORKING IN PULAY DENOUT - DENSITY MATRIX...produced when a key-word is used, e.g. COMPFG. - 15 - KEY-WORDS Page 2-8 DENOUT The density matrix at the end of the calculation is to be output in a form...suitable for input in another job. If an automatic dump due to the time being exceeded occurs during the current run then DENOUT is invoked

  16. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    Directory of Open Access Journals (Sweden)

    Atsuo Kawahara

    2016-05-01

    Full Text Available The zebrafish (Danio rerio is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR associated protein 9 (Cas9 system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  17. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish.

    Science.gov (United States)

    Kawahara, Atsuo; Hisano, Yu; Ota, Satoshi; Taimatsu, Kiyohito

    2016-05-13

    The zebrafish (Danio rerio) is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs) at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  18. Targeted plant genome editing via the CRISPR/Cas9 technology.

    Science.gov (United States)

    Li, Jian-Feng; Zhang, Dandan; Sheen, Jen

    2015-01-01

    Targeted modification of plant genome is key for elucidating and manipulating gene functions in basic and applied plant research. The CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated protein (Cas) technology is emerging as a powerful genome editing tool in diverse organisms. This technology utilizes an easily reprogrammable guide RNA (gRNA) to guide Streptococcus pyogenes Cas9 endonuclease to generate a DNA double-strand break (DSB) within an intended genomic sequence and subsequently stimulate chromosomal mutagenesis or homologous recombination near the DSB site through cellular DNA repair machineries. In this chapter, we describe the detailed procedure to design, construct, and evaluate dual gRNAs for plant codon-optimized Cas9 (pcoCas9)-mediated genome editing using Arabidopsis thaliana and Nicotiana benthamiana protoplasts as model cellular systems. We also discuss strategies to apply the CRISPR/Cas9 system to generating targeted genome modifications in whole plants.

  19. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    OpenAIRE

    Atsuo Kawahara; Yu Hisano; Satoshi Ota; Kiyohito Taimatsu

    2016-01-01

    The zebrafish (Danio rerio) is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system, have allowed researchers to generate diverse genomic modifications in whole animals and i...

  20. Reference Guide to Non-combustion Technologies for Remediation of Persistent Organic Pollutants in Soil, Second Edition - 2010

    Science.gov (United States)

    This report is the second edition of the U.S. Environmental Protection Agency's (US EPA's) 2005 report and provides a high level summary of information on the applicability of existing and emerging noncombustion technologies for the remediation of...

  1. Exercises in statistics for HA & HA(dat.) & BSc(B), 3rd semester

    DEFF Research Database (Denmark)

    The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business.......The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business....

  2. Editing the epigenome: technologies for programmable transcription and epigenetic modulation.

    Science.gov (United States)

    Thakore, Pratiksha I; Black, Joshua B; Hilton, Isaac B; Gersbach, Charles A

    2016-02-01

    Gene regulation is a complex and tightly controlled process that defines cell identity, health and disease, and response to pharmacologic and environmental signals. Recently developed DNA-targeting platforms, including zinc finger proteins, transcription activator-like effectors (TALEs) and the clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 system, have enabled the recruitment of transcriptional modulators and epigenome-modifying factors to any genomic site, leading to new insights into the function of epigenetic marks in gene expression. Additionally, custom transcriptional and epigenetic regulation is facilitating refined control over cell function and decision making. The unique properties of the CRISPR-Cas9 system have created new opportunities for high-throughput genetic screens and multiplexing targets to manipulate complex gene expression patterns. This Review summarizes recent technological developments in this area and their application to biomedical challenges. We also discuss remaining limitations and necessary future directions for this field.

  3. Effectively utilising a 3rd party 3D visualization component in a discrete event simulation environment for Joint Command and Control (JC2)

    CSIR Research Space (South Africa)

    Ramadeen, P

    2009-09-01

    Full Text Available A 3rd party 3-dimensional visualization tool (developed by the Council for Scientific and Industrial Research (CSIR)) is being used to visualize and assist with the development of a synthetic environment for joint command and control technology...

  4. Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

    Science.gov (United States)

    Liu, Tang; Shen, Jacson K; Li, Zhihong; Choy, Edwin; Hornicek, Francis J; Duan, Zhenfeng

    2016-04-01

    Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area.

  5. 20 September 2013 - Ambassador Z. Akram , Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva (3rd) with Mechanical and Materials Engineering Group Leader F. Bertinelli, Head of International Relations R. Voss, CMS Collaboration, Quaid-i-Azam University H. Hoorani, Permanent Mission First Secretary U. Iqbal Jadoon and LHC Consolidation, Industrial Services, Technology Department JP. Tock in front of the lift to the LHC tunnel at Point 1. Site Manager M. Décombaz on the back.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    20 September 2013 - Ambassador Z. Akram , Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva (3rd) with Mechanical and Materials Engineering Group Leader F. Bertinelli, Head of International Relations R. Voss, CMS Collaboration, Quaid-i-Azam University H. Hoorani, Permanent Mission First Secretary U. Iqbal Jadoon and LHC Consolidation, Industrial Services, Technology Department JP. Tock in front of the lift to the LHC tunnel at Point 1. Site Manager M. Décombaz on the back.

  6. The 2001 activities and the 3rd workshop of the human resources development project in FNCA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    In 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The 3rd Workshop on Human Resources Development in the Nuclear Field was held on October 29 to November 1, at the Nuclear Training Center of KAERI. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The secretariat for the Human Resources Development Project is provided by the Nuclear Training Center of the Korea Atomic Energy Research Institute and the Nuclear Technology and Education Center of the Japan Atomic Energy Research Institute. This report consists of presentation papers and materials at the Workshop as In-Workshop Activity, a document of project review on Human Resources Development for the fourth Coordinators Meeting of FNCA at Tokyo on March, 2002, a letter of proposal from the Project Leader of Japan to the project leaders of the participating countries, and training materials of participating countries as Outside-Workshop Activity. (author)

  7. Cis-, intra-, subgenesis, genome editing as modern technologies for modifying the crop genomes (review

    Directory of Open Access Journals (Sweden)

    Н. Е. Волкова

    2016-02-01

    Full Text Available Purpose. Reviewing the literature on modern technologies of genetic modification of crop genomes. Results. The current state of genetically modified plants creation is analyzed. The information on cis-, intra- and subgenic plants and their comparison with transgenic crops is given. Examples of cis- and intragenesis application for improving characteristics of crops are provided. Such state-of-the-art technology of crop genome modification as genome editing is considered. Conclusions. Technologies for producing cis-, intra-, subgenic plants are rapidly developing and resulting in crops of the 21st century that can solve the problem of food provision for a constantly growing world population with the least contrary to the public interest.

  8. Energy Technology Roadmaps: A Guide to Development and Implementation. 2014 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-01

    New low-carbon technologies show clear potential for transforming the global energy system, but a key challenge remains: what steps do governments and industry need to take to ensure their development and deployment? Roadmapping, used for decades in technology-intensive industries, is a useful tool to help address complicated issues strategically at the national, regional and global levels. To help turn political statements and analytical work into concrete action, the International Energy Agency (IEA) is developing a series of global roadmaps devoted to low-carbon energy technologies. Drawing upon the extensive IEA experience, this guide is aimed at providing countries and companies with the context, information and tools needed to design, manage and implement an effective energy technology roadmap process relevant to their own local circumstances and objectives. This edition of the Energy Technology Roadmaps: a guide to development and implementation includes more detailed guidance on how to identify key stakeholders, develop a technology baseline and development of indicators to help track progress against roadmap milestones. The IEA hopes that this guide and the examples and references it offers, together with the new IEA How2Guides, which provide technology-specific guidance, will help national and local policy makers and industry to develop strategies that accelerate the deployment of low-carbon energy technologies worldwide.

  9. The 3rd-order nonlinearity of bacteriorhodopsin by four-wave mixing

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The 3rd-order nonlinear optical susceptibility X(3) and the response time of the light-transducing biomolecule bacteriorhodopsin were measured with the four-wave mixing technique and a picosecond frequency-doubled Nd:YAG laser(532nm).The X(3) and the response time measured are 10-9 esu and 20 ps,respectively.The possible mechanism for generating the 3rd-order nonlinear optical susceptibility X(3) and response time were discussed.

  10. 3rd International Conference on NeuroRehabilitation

    CERN Document Server

    González-Vargas, José; Azorín, José; Akay, Metin; Pons, José

    2017-01-01

    The book reports on advanced topics in the areas of neurorehabilitation research and practice. It focuses on new methods for interfacing the human nervous system with electronic and mechatronic systems to restore or compensate impaired neural functions. Importantly, the book merges different perspectives, such as the clinical, neurophysiological, and bioengineering ones, to promote, feed and encourage collaborations between clinicians, neuroscientists and engineers. Based on the 2016 International Conference on Neurorehabilitation (ICNR 2016) held on October 18-21, 2016, in Segovia, Spain, this book covers various aspects of neurorehabilitation research and practice, including new insights into biomechanics, brain physiology, neuroplasticity, and brain damages and diseases, as well as innovative methods and technologies for studying and/or recovering brain function, from data mining to interface technologies and neuroprosthetics. In this way, it offers a concise, yet comprehensive reference guide to neurosurg...

  11. 3rd International Conference on High Performance Scientific Computing

    CERN Document Server

    Kostina, Ekaterina; Phu, Hoang; Rannacher, Rolf

    2008-01-01

    This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site loca...

  12. 3rd International Conference on Sustainable Design and Manufacturing

    CERN Document Server

    Howlett, Robert; Liu, Ying; Theobald, Peter

    2016-01-01

    This volumes consists of 59 peer-reviewed papers, presented at the International Conference on Sustainable Design and Manufacturing (SDM-16) held in Chania, Crete Greece in April 2016. Leading-edge research into sustainable design and manufacturing aims to enable the manufacturing industry to grow by adopting more advanced technologies, and at the same time improve its sustainability by reducing its environmental impact. SDM-16 covers a wide range of topics from sustainable product design and service innovation, sustainable process and technology for the manufacturing of sustainable products, sustainable manufacturing systems and enterprises, decision support for sustainability, and the study of societal impact of sustainability including research for circular economy. Application areas are wide and varied. The book will provide an excellent overview of the latest research and development in the area of Sustainable Design and Manufacturing.

  13. Radiographic findings on 3rd molars removed in 20-year-old men.

    Science.gov (United States)

    Rajasuo, Ari; Peltola, Jaakko; Ventä, Irja; Murtomaa, Heikki

    2003-10-01

    In this study we assess radiographic findings characteristic of mandibular 3rd molars that had required either routine or surgical extraction. X-ray findings relating to acute pericoronitis were also examined. The material was collected by investigating patient records and rotational panoramic radiographs of 20-year-old Finnish male conscripts (n = 738) treated during military service because of 3rd-molar-related problems. The follicle around the crown of mandibular 3rd molars with acute pericoronitis was enlarged in 19% of cases and in 13% of chronic symptom-free pericoronitis cases (not statistically significant difference). Mandibular 3rd molars extracted surgically were more often mesially inclined than those extracted routinely (61% vs. 23%; P pericoronitis [around 27% vs. 39% of the teeth routinely extracted (OR 0.5, 95% CI 0.3-0.8)]. In 86% of cases the space between 2nd molar and ramus of the mandible was narrower than the 3rd molar extracted surgically, whereas this was 62% in routine extraction cases (P < 0.001). We conclude that there are some typical 3rd-molar findings in rotational panoramic radiographs that show a need for surgical extraction.

  14. Survey of K-3rd-Grade Teachers' Knowledge of Ear Infections and Willingness to Participate in Prevention Programs

    Science.gov (United States)

    Danhauer, Jeffrey L.; Johnson, Carole E.; Caudle, Abby T.

    2011-01-01

    Purpose: Ear infections are prevalent in kindergarten through 3rd-grade (K-3rd) children and can affect their performance at school. Chewing gum, when administered by parents and teachers, can help prevent ear infections in children. This pilot study surveyed K-3rd-grade teachers in the Santa Barbara School Districts to assess their knowledge…

  15. File list: InP.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lar.50.AllAg.3rd_instar dm3 Input control Larvae 3rd instar SRX287726,SRX331369...87917,SRX287921,SRX288023,SRX467107,SRX016172,SRX016173 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Lar.50.AllAg.3rd_instar.bed ...

  16. File list: Oth.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lar.20.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX318781,SRX31878...1403,SRX495243 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.20.AllAg.3rd_instar.bed ...

  17. File list: Unc.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lar.50.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX022335,SRX032124,SRX032123,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.50.AllAg.3rd_instar.bed ...

  18. File list: InP.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lar.20.AllAg.3rd_instar dm3 Input control Larvae 3rd instar SRX467108,SRX287726...67103,SRX288024,SRX288023,SRX104976,SRX016172,SRX467107,SRX016173 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Lar.20.AllAg.3rd_instar.bed ...

  19. File list: InP.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Pol.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lar.20.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.20.AllAg.3rd_instar.bed ...

  1. File list: ALL.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lar.10.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX104963,SRX104968,...SRX287718,SRX022334,SRX104976,SRX467107,SRX013086,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.10.AllAg.3rd_instar.bed ...

  2. File list: Oth.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lar.50.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX318781,SRX31878...5306 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.50.AllAg.3rd_instar.bed ...

  3. File list: InP.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lar.10.AllAg.3rd_instar dm3 Input control Larvae 3rd instar SRX016172,SRX016173...87701,SRX287922,SRX467104,SRX287918,SRX287718,SRX104976,SRX467107 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Lar.10.AllAg.3rd_instar.bed ...

  4. File list: Unc.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lar.10.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX032124,SRX032123,SRX022335,SRX022334,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.10.AllAg.3rd_instar.bed ...

  5. File list: Oth.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lar.10.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX104963,SRX10497...4971,SRX331403 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.10.AllAg.3rd_instar.bed ...

  6. File list: Oth.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lar.05.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX104964,SRX10496...1403,SRX495243 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.05.AllAg.3rd_instar.bed ...

  7. File list: ALL.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lar.20.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX1038029,SRX103803...SRX013082,SRX467107,SRX016173,SRX215499,SRX495243,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.20.AllAg.3rd_instar.bed ...

  8. File list: ALL.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lar.05.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX104964,SRX104963,...SRX287718,SRX331401,SRX287658,SRX331366,SRX287906,SRX287678 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.05.AllAg.3rd_instar.bed ...

  9. File list: Pol.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lar.10.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.10.AllAg.3rd_instar.bed ...

  10. File list: Unc.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lar.20.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX022335,SRX032124,SRX022334,SRX032123,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.20.AllAg.3rd_instar.bed ...

  11. File list: Pol.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lar.05.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287907,SRX28790...8,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.05.AllAg.3rd_instar.bed ...

  12. File list: Pol.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lar.50.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.50.AllAg.3rd_instar.bed ...

  13. File list: ALL.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lar.50.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX1038029,SRX103803...SRX467060,SRX495306,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.50.AllAg.3rd_instar.bed ...

  14. File list: Unc.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lar.05.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038031,SRX103802...9,SRX1038032,SRX1038030,SRX022335,SRX022334,SRX032124,SRX013058,SRX032123 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.05.AllAg.3rd_instar.bed ...

  15. 3rd ENRI International Workshop on ATM/CNS

    CERN Document Server

    2014-01-01

    The Electronic Navigation Research Institute (ENRI) held its third International Workshop on ATM / CNS in 2013 with the theme of "Drafting the future sky". There is worldwide activity taking place in the research and development of modern air traffic management (ATM) and its enabling technologies in Communication, Navigation and Surveillance (CNS). Pioneering work is necessary to contribute to the global harmonization of air traffic management and control. At this workshop, leading experts in  research, industry and academia from around the world met to share their ideas and approaches on ATM/CNS related topics.

  16. 3rd International Conference on Applied Mathematics and Approximation Theory

    CERN Document Server

    Duman, Oktay

    2016-01-01

    This special volume is a collection of outstanding theoretical articles presented at the conference AMAT 2015, held in Ankara, Turkey from May 28-31, 2015, at TOBB University of Economics and Technology. The collection is suitable for a range of applications: from researchers and practitioners of applied and computational mathematics, to students in graduate-level seminars. Furthermore it will be a useful resource for all science libraries. This book includes 27 self-contained and expertly-refereed chapters that provide numerous insights into the latest developments at the intersection of applied and computational mathematics, engineering, and statistics.

  17. China Satellite Navigation Conference (CSNC) 2012 Proceedings : The 3rd China Satellite Navigation Conference

    CERN Document Server

    Liu, Jingnan; Yang, Yuanxi; Fan, Shiwei

    2012-01-01

    Proceedings of the 3rd China Satellite Navigation Conference (CSNC2012) presents selected research papers from CSNC2012, held on 15-19 May in Guanzhou, China. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou system especially. They are divided into 9 topics to match the corresponding sessions in CSNC2012, which broadly covered key topics in GNSS. Readers can learn about the BeiDou system and keep abreast of the latest advances in GNSS techniques and applications. SUN Jiadong is the Chief Designer of the Compass/BeiDou system, and the Academician of Chinese Academy of Sciences; LIU Jingnan is a professor at Wuhan University, and the Academician of Chinese Academy of Engineering; YANG Yuanxi is a professor at China National Administration of GNSS and Applications, and the Academician of Chinese Academy of Sciences; FAN Shiwei öis a researcher on satellite navigation.

  18. 3rd International Conference on Opto-Electronics and Applied Optics

    CERN Document Server

    Chakrabarti, Satyajit; Reehal, Haricharan; Lakshminarayanan, Vasudevan

    2017-01-01

    The Proceedings of 3rd International Conference on Opto-Electronics and Applied Optics, OPTRONIX 2016 is an effort to promote and present the research works by scientists and researchers including students in India and abroad in the area of Green Photonics and other related areas as well as to raise awareness about the recent trends of research and development in the area of the related fields. The book has been organized in such a way that it will be easier for the readers to go through and find out the topic of their interests. The first part includes the Keynote addresses by Rajesh Gupta, Department of Energy Science and Engineering, Indian Institute of Technology, Bombay; P.T. Ajith Kumar, President and Leading Scientist Light Logics Holography and Optics, Crescent Hill, Trivandrum, Kerala; and K.K. Ghosh, Institute of Engineering & Management, Kolkata, India.  The second part focuses on the Plenary and Invited Talks given by eminent scientists namely, Vasudevan Lakshminarayanan, University of Wate...

  19. Combining Induced Pluripotent Stem Cells and Genome Editing Technologies for Clinical Applications.

    Science.gov (United States)

    Chang, Chia-Yu; Ting, Hsiao-Chien; Su, Hong-Lin; Jeng, Jing-Ren

    2017-02-17

    In this review, we introduce current developments in induced pluripotent stem cells (iPSCs), site-specific nuclease (SSN)-mediated genome editing tools, and the combined application of these two novel technologies in biomedical research and therapeutic trials. The sustainable pluripotent property of iPSCs in vitro not only provides unlimited cell sources for basic research but also benefits precision medicines for human diseases. In addition, rapidly evolving SSN tools efficiently tailor genetic manipulations for exploring gene functions and can be utilized to correct genetic defects of congenital diseases in the near future. Combining iPSC and SSN technologies will create new reliable human disease models with isogenic backgrounds in vitro and provide new solutions for cell replacement and precise therapies.

  20. Extending CRISPR-Cas9 Technology from Genome Editing to Transcriptional Engineering in the Genus Clostridium

    Science.gov (United States)

    Bruder, Mark R.; Pyne, Michael E.; Moo-Young, Murray

    2016-01-01

    ABSTRACT The discovery and exploitation of the prokaryotic adaptive immunity system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins have revolutionized genetic engineering. CRISPR-Cas tools have enabled extensive genome editing as well as efficient modulation of the transcriptional program in a multitude of organisms. Progress in the development of genetic engineering tools for the genus Clostridium has lagged behind that of many other prokaryotes, presenting the CRISPR-Cas technology an opportunity to resolve a long-existing issue. Here, we applied the Streptococcus pyogenes type II CRISPR-Cas9 (SpCRISPR-Cas9) system for genome editing in Clostridium acetobutylicum DSM792. We further explored the utility of the SpCRISPR-Cas9 machinery for gene-specific transcriptional repression. For proof-of-concept demonstration, a plasmid-encoded fluorescent protein gene was used for transcriptional repression in C. acetobutylicum. Subsequently, we targeted the carbon catabolite repression (CCR) system of C. acetobutylicum through transcriptional repression of the hprK gene encoding HPr kinase/phosphorylase, leading to the coutilization of glucose and xylose, which are two abundant carbon sources from lignocellulosic feedstocks. Similar approaches based on SpCRISPR-Cas9 for genome editing and transcriptional repression were also demonstrated in Clostridium pasteurianum ATCC 6013. As such, this work lays a foundation for the derivation of clostridial strains for industrial purposes. IMPORTANCE After recognizing the industrial potential of Clostridium for decades, methods for the genetic manipulation of these anaerobic bacteria are still underdeveloped. This study reports the implementation of CRISPR-Cas technology for genome editing and transcriptional regulation in Clostridium acetobutylicum, which is arguably the most common industrial clostridial strain. The developed genetic tools enable simpler, more reliable

  1. 3rd International Winter School and Conference on Network Science

    CERN Document Server

    Barzel, Baruch; Puzis, Rami

    2017-01-01

    This book contains original research chapters related to the interdisciplinary field of complex networks spanning biological and environmental networks, social, technological, and economic networks. Many natural phenomena can be modeled as networks where nodes are the primitive compounds and links represent their interactions, similarities, or distances of sorts. Complex networks have an enormous impact on research in various fields like biology, social sciences, engineering, and cyber-security to name a few. The topology of a network often encompasses important information on the functionality and dynamics of the system or the phenomenon it represents. Network science is an emerging interdisciplinary discipline that provides tools and insights to researchers in a variety of domains. NetSci-X is the central winter conference within the field and brings together leading researchers and innovators to connect, meet, and establish interdisciplinary channels for collaboration. It is the largest and best known even...

  2. Fabrication of DUPIC fuel for the 3rd irradiation test

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woong Ki; Kim, S. S.; Lee, J. W. and others

    2001-09-01

    In this project, based on the simulated DUPIC fuel fabrication experiment and DUPIC fuel characterization experiment at PIEF, DUPIC fuel manufacturing technologies and processes have been developed at DFDF(DUPIC Fuel Development Facility, IMEF M6). DUPIC fuel has been fabricated for the irradiation test at a research reactor. SIMFUEL and DUPIC fuel fabricated using spent PWR fuel were successfully irradiated at HANARO reactor. In this study, DUPIC fuel pellets and mini-elements were manufactured in March 2001 for the third irradiation test to closely investigate the dynamic characteristics of DUPIC fuel at a reactor core for long period. As a result of the experiment, 15 DUPIC pellets with 10.194 10.312 g/cm{sup 3} of sintered density, 3.53 {delta}9.48 {mu}m of averaged grain size, and less than Ra 0.81 {mu}m of surface roughness satisfying the specifications of DUPIC fuel for the third irradiation test have been remotely fabricated at hot cell. 5 DUPIC pellets were loaded in a mini-element made of Zircaloy-4. The soundness of the weld of the mini-elements has been evaluated by microstructural test, helium leak test, and X-ray inspection. Three DUPIC mini-elements are currently under the third irradiation test at HANARO reactor.

  3. Microstructure Modeling of 3rd Generation Disk Alloy

    Science.gov (United States)

    Jou, Herng-Jeng

    2008-01-01

    The objective of this initiative, funded by NASA's Aviation Safety Program, is to model, validate, and predict, with high fidelity, the microstructural evolution of third-generation high-refractory Ni-based disc superalloys during heat treating and service conditions. This initiative is a natural extension of the DARPA-AIM (Accelerated Insertion of Materials) initiative with GE/Pratt-Whitney and with other process simulation tools. Strong collaboration with the NASA Glenn Research Center (GRC) is a key component of this initiative and the focus of this program is on industrially relevant disk alloys and heat treatment processes identified by GRC. Employing QuesTek s Computational Materials Dynamics technology and PrecipiCalc precipitation simulator, physics-based models are being used to achieve high predictive accuracy and precision. Combining these models with experimental data and probabilistic analysis, "virtual alloy design" can be performed. The predicted microstructures can be optimized to promote desirable features and concurrently eliminate nondesirable phases that can limit the reliability and durability of the alloys. The well-calibrated and well-integrated software tools that are being applied under the proposed program will help gas turbine disk alloy manufacturers, processing facilities, and NASA, to efficiently and effectively improve the performance of current and future disk materials.

  4. PREFACE: 3rd International Symposium on Functional Materials 2009 (ISFM 2009) 3rd International Symposium on Functional Materials 2009 (ISFM 2009)

    Science.gov (United States)

    Kiwon, Kim; Li, Lu; Taehyun, Nam; Jouhyeon, Ahn

    2010-05-01

    The 3rd International Symposium on Functional Materials 2009 (ISFM 2009) and its preconference, Advances in Functional Materials 2009 (AFM 2009), were successfully held in the Republic of Korea from 15-18 June 2009 and in the People's Republic of China from 8-12 June 2009, respectively. The two conferences attracted over 300 oral and poster presentations from over 12 countries including Australia, Canada, China, Germany, Japan, India, Israel, Korea, The Netherlands, Thailand, the UK and the USA. In the two conferences, eight keynote lectures were delivered by S Miyazaki, S A Akbar, D J Singh, C Suryanarayana, M~Greenblatt, H Zhang, T Sato and J Ding. This topical issue of Physica Scripta contains papers presented at the ISFM 2009 and AFM 2009. Keyan Li from Dalian University, People's Republic of China, presents some empirical formulae to estimate the elastic moduli of rocksalt-, zincblende- and chalcopyrite-structured crystals, on the basis of electronegativities of bonded atoms in the crystallographic frame. Min-Jung Kim from Hanyang University, Korea, reports on the preparation and characterization of carboxyl functionalization of magnetite nanoparticles for oligonucleotide immobilization. F Yan from the National University of Singapore studies the fabrication of Bi(Fe0.5Sc0.5)O3-PbTiO3 (BSF-PT) thin films by pulsed laser deposition, and the enhanced magnetic moment with respect to BiFeO3-PbTiO3. Dong-Gil Lee from Pusan National University, Korea, reports on the sterilization of enteropathogenic Escherichia coli using nanofiber TiO2 films prepared by the electrostatic spray method. Sang-Eun Park from the Korea Institute of Science and Technology reports on the study of encapsulated Fe3O4 nanoparticles with a silica thin layer with a reversible capacity of about 363 mAhg-1. Other researchers report on many other exiting achievements in the fields of ferromagnetic materials, magneto-optical materials, thermoelectric materials, shape memory materials, fuel-cell and

  5. 3rd International Conference on Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    1. Introduction 'Turbulent Mixing and Beyond' (TMB) is the programme established for scientists, by scientists. It is merit-based, and is shaped by requirements of academic credentials, and novelty and quality of information. The goals of this programme are to expose the generic problem of non-equilibrium turbulent processes to a wide scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in application of novel approaches in a broad range of phenomena, in which the turbulent processes occur, and to have a potential impact on technology. The programme was founded in 2007 with the support of the international scientific community and of the US National Science Foundation, the US Air Force Office of the Scientific Research and its European Office for Research and Development in the UK, the UNESCO-IAEA International Centre for Theoretical Physics in Italy, the Commissariat l'Energie Atomique in France, the US Department of Energy and the Department of Energy National Laboratories, the Institute for Laser Engineering in Japan, and the University of Chicago in the USA. The International Conference on Turbulent Mixing and Beyond provides opportunities to bring together researchers from the areas, which include but are not limited to, fluid dynamics, plasmas, high energy density physics, astrophysics, material science, combustion, atmospheric and earth sciences, nonlinear and statistical physics, applied mathematics, probability and statistics, data processing and computations, optics and communications, and to have their attention focused on the long-standing formidable task of non-equilibrium turbulent processes. 2. Non-equilibrium turbulent processes Non-equilibrium turbulent processes play a key role in a wide variety of phenomena, ranging from astrophysical to atomistic scales, under either high or low energy density conditions. Inertial confinement and magnetic fusion, light-matter interaction and

  6. The Role of Training and Promotion to Increase The 3rd Party Funds Indonesian Islamic Banking

    Directory of Open Access Journals (Sweden)

    Rahmat Hidayat

    2014-03-01

    Full Text Available Objective – This study aims to determine whether the role of training is much larger than the promotion in raising third-party funds in Islamic banks in Indonesia given the cost of the training is spent is greater than the cost of promotion. This study empirically examines the relationship and impact of training and promotion to raise funds for a 3rd party in Indonesia Islamic banks.Methods – This study uses secondary data Islamic commercial banks in the form of panel (time-series and cross-section of Bank Indonesia data from 2010 until 2012. There are two independent variables training cost (X1 and promotion cost (X2 and one dependent variable is 3rd-party funds (Y. The analysis technique used path analysis to examine the role of training and the promotion of financial performance (The 3rd Party Funds.Result – Simultaneously, training and promotion gives an effect by 52%, and partially or individual training gives an insignificant negative effect, while the promotion has a significant positive impact on financial performance (financial-party funds on Islamic banking.Conclusion – The role of promotion is higher in raising The 3rd Party Funds than training. Keywords : Cost, Training, Promotion, The 3rd Party Funds 

  7. Collaborative study for the establishment of the 3rd international standard for neomycin.

    Science.gov (United States)

    Rautmann, G; Daas, A; Buchheit, K-H

    2013-01-01

    An international collaborative study was organised to establish the World Health Organization (WHO) 3(rd) International Standard (IS) for neomycin. Ten laboratories from different countries participated in the collaborative study. The potency of the candidate material, a freeze-dried preparation, was estimated by microbiological assays with sensitive micro-organisms. To ensure continuity between consecutive batches, the 2(nd) IS for neomycin was used as a standard. Based on the results of the study, the 3(rd) IS for neomycin was adopted at the meeting of the WHO Expert Committee on Biological Standardization (ECBS) in 2012 with an assigned potency of 19,050 IU per vial. The 3(rd) IS for neomycin is available from the European Directorate for the Quality of Medicines & HealthCare (EDQM).

  8. The 3rd International Conference on Continental Earthquakes, Mechanism, Prediction, Emergency Management & Insurance

    Institute of Scientific and Technical Information of China (English)

    Dr.HuangJing

    2004-01-01

    The 3rd International Conference on Continental Earthquakes, Mechanism, Prediction, Emergency Management & Insurance (the 3rd ICCE) was held on July 9-14, 2004 in Beijing, China. The ICCE has been held every decade since it was launched over twenty years ago. The first ICCE, with the title """"International Symposium on Continental Seismicity and Earthquake Prediction""""(ISCSEP), had international sponsorship and was supported by e.g., UNESCO and hosted by the Seismological Society of China (SSC)in Beijing in 1982. In 1992 in response to the initiatives from the UN's International Decade for Natural Disaster Reduction (IDNDR),

  9. PREFACE: 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech 2015)

    Science.gov (United States)

    Refsnes, Magne, Prof; Gusev, Alexander, Dr; Godymchuk, Anna, Dr; Bogdan, Anna

    2015-11-01

    The 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech2015) was held on 21-22 May 2015 in Tambov, Russia, and was jointly organized by Tambov Derzhavin State University (Russia), the Norwegian Institute of Public Health (Norway), the National University of Science and Technology MISiS (Russia), Tomsk Polytechnic University (Russia) and Tomsk State University. The conference gathered experienced and young researchers, post-docs and students, working in the fieldof nanotechnologies, nanomedicine, nano(eco)toxicology and risk assessment of nanomaterials, in order to facilitate the aggregation and sharing of interests and results for better collaboration and visibility of activity. The goal of Nanobiotech2015 was to bring researchers and practitioners together to share the latest knowledge on nanotechnology-specific risks to occupational and environmental health and assessing how to reduce these potential risks. The main objective of the conference is to identify, systematize and solve current scientific problems inthe sphere of nanobiotechnologies, nanomedicine and nanotoxicology, in order to join forces todetermine prospective areas and compose working groups of interested co-workers for carrying out interdisciplinary research projects. The topics of Nanobiotech2015 were: (1) Nanotechnologies in pharmaceutics and medicine; (2) Sources and mechanisms of nanoparticle release into the environment; (3) Ecological and biological effects of nanoparticles; (4) (Eco)toxicology of nanomaterials; (5) Methods for detection of nanoparticles in the environment and in biological objects; and (6) Physico-chemical properties of nanoparticles in the environment. We want to thank the Organizing Committee, the universities and sponsors supporting the conference,and everyone who contributed to the organization of this meeting, for their contribution towards the conference and for their contributions to these

  10. Making Classroom Assessment Work. Third Edition

    Science.gov (United States)

    Davies, Anne

    2011-01-01

    3rd Edition! When should we assess, and when should we evaluate? What might be the results of evaluating too early or too much? How do we know if we are evaluating the right things? How do we know what makes sense for the learner and for the course? These questions are at the heart of "Making Classroom Assessment Work." This book combines powerful…

  11. Litigating for change: proceedings from the 3rd Symposium on HIV, Law and Human Rights. Introduction.

    Science.gov (United States)

    2011-10-01

    From 9-10 June 2011, the 3rd Symposium on HIV, Law and Human Rights took place in Toronto, drawing over 150 participants from across Canada. The event built on the success of the two previous Symposia and brought together policymakers, legal professionals, health researchers, students, activists, community organizations and people living with HIV or from communities particularly affected by HIV.

  12. Guangxi Pingguo Aluminum Alumina 3rd Phase Project to Put Into Production

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>In April,the handover ceremony was held for the first completed sub-project of the 3rd phase of 900,000-ton alumina project of China Alu- minum Guangxi Company (Pingguo Aluminum in short),standing for the commencement of

  13. The 3rd World Integrative Medicine Congress Was Held in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 3rd World Integrative Medicine Congress was held in Guangzhou,China,from September 22 to 24,2007,sponsored by the Chinese Association of the Integrative Medicine and co-organized by Guangdong Provincial Hospital of Chinese Medicine,Guangdong Integrative Medicine Association and Guangdong Provincial Academy of Chinese Medical Sciences.

  14. Time use of Hellene 3rd and 4th graders during a school day

    NARCIS (Netherlands)

    Vleioras, Georgios

    2010-01-01

    Using data from the time diaries of 164 Hellene 3rd and 4th graders interviewed in their homes in March 2007, individual differences in time-use patterns were investigated. The participants rested for 9 hours 10 minutes, and spent 57.0%, 21.7%, and 5.0% of their waking time on school-related

  15. A 3rd Order Low Power Switched Current Sigma-Delta Modulator

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Herald Holger; Bogason, Gudmundur

    1996-01-01

    This paper presents a 3rd order switched current Sigma-Delta modulator. The Sigma-Delta modulator operates at a sampling rate of 600kHz and the signal band is 5.5kHz, i.e. an oversampling factor of 54.5 is used. Multiple input signals are used to reduce the internal signal swings which results...

  16. Summary of the 3rd LHC Crab Cavity Workshop (LHC-CC09)

    CERN Document Server

    Zimmermann, Frank; Koutchouk, Jean-Pierre; Delayen, Jean; Pierini, Paolo; Ciapala, Edmond; McIntosh, Peter; Giovannozzi, Massimo; Brüning, Oliver; Collier, Paul; Funakoshi, Yoshihiro

    2010-01-01

    The 3rd workshop on crab compensation for the LHC luminosity upgrade (LHC-CC09) was held September 16-18, 2008 at CERN, Geneva, Switzerland. The workshop was organized by joint collaboration of CERN, EUCARD, KEK and US-LARP. Approximately 50 workshop participants from 3 continents and several institutions discussed the future strategy of implementing crab cavities in the LHC

  17. Time use of Hellene 3rd and 4th graders during a school day

    NARCIS (Netherlands)

    Vleioras, Georgios

    2010-01-01

    Using data from the time diaries of 164 Hellene 3rd and 4th graders interviewed in their homes in March 2007, individual differences in time-use patterns were investigated. The participants rested for 9 hours 10 minutes, and spent 57.0%, 21.7%, and 5.0% of their waking time on school-related activit

  18. Time use of Hellene 3rd and 4th graders during a school day

    NARCIS (Netherlands)

    Vleioras, Georgios

    2010-01-01

    Using data from the time diaries of 164 Hellene 3rd and 4th graders interviewed in their homes in March 2007, individual differences in time-use patterns were investigated. The participants rested for 9 hours 10 minutes, and spent 57.0%, 21.7%, and 5.0% of their waking time on school-related activit

  19. The 3rd China Standardization Forum Held in Urumqi, Xinjiang Uygur Autonomous Region

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ On Aug. 14th-15th, the 3rd China Standardization Forum, hosted by Standardization Administration of China(SAC), sponsored by China Association for Standardization (CAS) and associated by the Bureau of Quality &Technical Supervision of Xinjiang Uygur Autonomous Region of the People's Republic of China, was held in Urumqi, Xinjiang.

  20. Using Food as a Tool to Teach Science to 3rd Grade Students in Appalachian Ohio

    Science.gov (United States)

    Duffrin, Melani W.; Hovland, Jana; Carraway-Stage, Virginia; McLeod, Sara; Duffrin, Christopher; Phillips, Sharon; Rivera, David; Saum, Diana; Johanson, George; Graham, Annette; Lee, Tammy; Bosse, Michael; Berryman, Darlene

    2010-01-01

    The Food, Math, and Science Teaching Enhancement Resource (FoodMASTER) Initiative is a compilation of programs aimed at using food as a tool to teach mathematics and science. In 2007 to 2008, a foods curriculum developed by professionals in nutrition and education was implemented in 10 3rd-grade classrooms in Appalachian Ohio; teachers in these…

  1. Participants to the 3rd HEP Information Resources Summit, 6-7 May 2009

    CERN Multimedia

    Fermilab, Photo Service

    2009-01-01

    The broad theme of the 3rd HEP Information Resources Summit was "Collaboration between Information Services." As HEP increasingly borders fields such as instrumentation and astrophysics, it was discussed what potential interrelationships and communication this group have to serve this broader research community seamlessly.

  2. Starting Young: Massachusetts Birth-3rd Grade Policies That Support Children's Literacy Development

    Science.gov (United States)

    Cook, Shayna; Bornfreund, Laura

    2015-01-01

    Massachusetts is one of a handful of states that is often recognized as a leader in public education, and for good reason. The Commonwealth consistently outperforms most states on national reading and math tests and often leads the pack in education innovations. "Starting Young: Massachusetts Birth-3rd Grade Policies that Support Children's…

  3. Choice for All: Proceedings of the International Conference of the Association for the Advancement of Rehabilitation Technology = Choix pour tous: Conference internationale pour le developpement de la technologie en readaptation (3rd, Montreal, Quebec, Canada, June 25-30, 1988). ICAART Volume III.

    Science.gov (United States)

    RESNA: Association for the Advancement of Rehabilitation Technology, Washington, DC.

    These proceedings were composed of 290 papers, submitted by 700 authors from 15 countries, in the field of rehabilitation engineering and technology. Of the 290 papers, 13 are written in French. Papers are generally two to four pages in length, and are organized within the following areas of rehabilitation technology: service delivery practice (15…

  4. FOREWORD: 3rd International Workshop on New Computational Methods for Inverse Problems (NCMIP 2013)

    Science.gov (United States)

    Blanc-Féraud, Laure; Joubert, Pierre-Yves

    2013-10-01

    Conference logo This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 3rd International Workshop on New Computational Methods for Inverse Problems, NCMIP 2013 (http://www.farman.ens-cachan.fr/NCMIP_2013.html). This workshop took place at Ecole Normale Supérieure de Cachan, in Cachan, France, on 22 May 2013, at the initiative of Institut Farman. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of the ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 (http://www.farman.ens-cachan.fr/NCMIP_2012.html). The NCMIP Workshop focused on recent advances in the resolution of inverse problems. Indeed inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational

  5. SESAME — A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    Å°lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ˜133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  6. SESAME - A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    U˝Lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ~133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  7. 3rd May 2009 - Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, visiting ATLAS experimental area, LHC tunnel and CERN Control Centre with CERN Director-General R. Heuer, Collaboration Spokesperson F. Gianotti and Beams Department Head P. Collier.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    090506101-08: signature of the guest book and exchange of gifts; 090506109 + 46-64: Japanese Ambassador to the United Nations Office S. Kitajima, Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer, Non Member-State relations Adviser J. Ellis and ATLAS Collaboration Spokesperson F. Gianotti visiting the LHC tunnel at Point 1; 090506110-11 + 28-45: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda and his delegation visiting ATLAS experimental area with CERN Japanese users and Management; 090506112 + 86-94: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer and Japanese users in front of an LHC superconducting magnet; sLHC Project Leader also present. 090506113-19: Arrival of Japanese Min...

  8. The loss of student idealism in the 3rd-year clinical clerkships.

    Science.gov (United States)

    Griffith, C H; Wilson, J F

    2001-03-01

    The purpose of this study was to specify how student attitudes toward different types of patients and the profession change during clinical rotations. A questionnaire was given to all medical students prior to 3rd-year rotations regarding their attitudes toward the medical profession and patient types. It was given again after students completed their 16-week medicine-surgery clerkship. Eighty-eight of 96 students responded to pre- and posttests. Students became less idealistic toward two patient groups: the elderly and people with chronic pain. After clerkship, students believed a greater percentage of the elderly were demented (26% increasing to 35%, p = .09 and that a greater percentage of patients with chronic pain are drug seekers (15% increasing to 24%, p = .004). The authors conclude that in the 3rd year of medical school students become less idealistic toward elderly patients, those with chronic pain, and the profession.

  9. Conference report: the 3rd Global CRO Council for Bioanalysis at the International Reid Bioanalytical Forum.

    Science.gov (United States)

    Breda, Massimo; Garofolo, Fabio; Caturla, Maria Cruz; Couerbe, Philippe; Maltas, John; White, Peter; Struwe, Petra; Sangster, Timothy; Riches, Suzanne; Hillier, Jim; Garofolo, Wei; Zimmerman, Thomas; Pawula, Maria; Collins, Eileen; Schoutsen, Dick; Wieling, Jaap; Green, Rachel; Houghton, Richard; Jeanbaptiste, Bernard; Claassen, Quinton; Harter, Tammy; Seymour, Mark

    2011-12-01

    The 3rd Global CRO Council Closed Forum was held on the 3rd and 4th July 2011 in Guildford, United Kingdom, in conjunction with the 19th International Reid Bioanalytical Forum. In attendance were 21 senior-level representatives from 19 CROs on behalf of nine European countries and, for many of the attendees, this occasion was the first time that they had participated in a GCC meeting. Therefore, this closed forum was an opportunity to increase awareness of the aim of the GCC and how it works, share information about bioanalytical regulations and audit findings from different agencies, their policies and procedures and also to discuss some topics of interest and aim to develop ideas and provide recommendations for bioanalytical practices at future GCC meetings in Europe.

  10. [Complications of multiple pregnancy in the 2nd and 3rd trimesters].

    Science.gov (United States)

    Poniedziałek-Czajkowska, E; Leszczyńska-Gorzelak, B; Oleszczuk, J

    2000-11-01

    Multiple pregnancy contributes to higher maternal and fetal risks than a single one. Complications typical only for multiple pregnancy such as PROM with preterm delivery, intrauterine death or IUGR of one of twins can occur during 2nd and 3rd trimester. Treatment in such situations is usually difficult and often controversial because of simultaneous presence of an alive and/or healthy fetus and possible risk for mother. The paper presents such situations and possible ways of treatment.

  11. Meet Cambodia's Needs——The 3rd China Auto International Exhibition Tour

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The 3rd China Auto International Exhibition Tour in 2005 gathered 39 well-known Chinese home brands,traveled across the Indo-China Peninsula and finally arrived at Phnom Penh,the capital of Cambodia.The Chinese automobiles got warm welcome from the local people due to the low price and good quality of the Chinese automobiles and living standard of this developing country.

  12. Insights from the 3rd World Congress on Integrated Computational Materials Engineering

    Science.gov (United States)

    Howe, D.; Goodlet, B.; Weaver, J.; Spanos, G.

    2016-05-01

    The 3rd World Congress on Integrated Computational Materials Engineering (ICME) was a forum for presenting the "state-of-the-art" in the ICME discipline, as well as for charting a path for future community efforts. The event concluded with in an interactive panel-led discussion that addressed such topics as integrating efforts between experimental and computational scientists, uncertainty quantification, and identifying the greatest challenges for future workforce preparation. This article is a summary of this discussion and the thoughts presented.

  13. Risk factors for 3rd and 4th degree perineal tear.

    Science.gov (United States)

    Eskandar, O; Shet, D

    2009-02-01

    We reviewed 3,038 deliveries at our hospital, over a period of 2 years (2005 and 2006) to identify risk factors for 3rd and 4th degree perineal tear. We used the hospital database and labour ward registry book and reviewed patients' record notes. After excluding elective and emergency caesarean sections, 2,278 women had delivered vaginally, from which 36 patients had 3rd/4th degree perineal tears as defined by the RCOG Green top guidelines No 29 (2007). A total of 2,242 women who delivered vaginally without 3rd/4th degree perineal tears were used as controls in this study. The rate of 3rd/4th degree perineal tear was 1.18% for all deliveries and 1.58% for vaginal deliveries. Occiptoposterior position during delivery (OR: 69.8), primigravida (OR: 5.8), and high birth weight (OR: 1.19) are risk factors for anal sphincter tear. However, induction of labour (OR: 0.71), use of medio-lateral episiotomy (OR: 0.35), epidural analgesia (OR: 0.88) and instrumental delivery of occipitoanterior position (OR: 0.77) reduced the risk of severe perineal tear. Primipara and occipitoposterior position (OP) during delivery are the only statistically significant risks for the occurrence of severe perineal damage. High birth weight is a risk factor but it is not statistically significant. Instrumental delivery of OP position is a highly statistically significant risk factor. On the other hand, induction of labour (IOL), epidural analgesia and instrumental delivery for occipitoanterior position are protective factors against anal sphincter injury, although they did not reach statistical significance.

  14. 学习模式及其应用——《教育传播与技术研究手册(第三版)》第四部分述评%Learning Models and Its Application:Review on Part IV of Handbook of Research on Educational Communications and Technology (3rd Version)

    Institute of Scientific and Technical Information of China (English)

    焦建利; 何秋琳; 詹春青

    2010-01-01

    概要介绍并评述了J.Michael Spector,M.David Merrill,Jeroen van Merrienboer和Marcy P.Driscoll主编的[Handbook of Research on Educational Communication and Technology (Third edidon),Lawrence Erlbaum Associates2008年出版]第四部分"学习模式",共分为四个部分:在人类认知结构与基于技术的教学部分,回顾了人类认知结构的进化基础和认知负荷理论提出的五条教学原理;在九种面向学校内外的学习通用模式部分,分析了教育传播与技术视角下的九种学习通用模式;在模式特定领域与专业中的应用部分,讨论了各种模式在阅读、数学、科学、法律以及医学五个领域的应用;最后对教育传播与技术学习模式研究基础的特点及各学习模式之间的关系进行了讨论、总结和展望.

  15. Fiscal 1999 achievement report on regional consortium research and development project. Regional consortium research field (Development of super-devices for medical equipment by 3-dimensional microstructure machining technology - 3rd year); 1999 nendo micro sanjigen kako gijutsu ni yoru iryo kikiyo super device no kaihatsu seika hokokusho (dai 3 nendo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    In the development of micromechanisms, a highly efficient micromotor capable of outputting 25g/cm is developed, in which a DC motor, 4mm in diameter and 12.5mm in length, and a deceleration mechanism are combined. A technology is established of manufacturing microtubes 0.1mm in internal diameter of various materials for use with medical equipment. A direct cam screw type discharge mechanism for minute amounts is developed. It is now foreseen that a cartridge (air pressurized) discharge mechanism and a tube pump will be commercialized. A microjoint is developed with a built-in micro check valve for medicine flow channels. A microfilter is developed using a polypropylene hollow yarn membrane. A microsensor is developed, which responds to a 0.01-second change in flow rate at an error rate of {+-}3% or less. A microcomputer control system is test-produced. Newly developed devices are integrated for the test production of a portable device for sustained infusion of medicine, and the product is found to be superior to the existing systems. Also described are the utilization of various micromachining techniques. (NEDO)

  16. Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities, 3rd edition.

    Science.gov (United States)

    Patel, Vikram; Chisholm, Dan; Parikh, Rachana; Charlson, Fiona J; Degenhardt, Louisa; Dua, Tarun; Ferrari, Alize J; Hyman, Steve; Laxminarayan, Ramanan; Levin, Carol; Lund, Crick; Medina Mora, María Elena; Petersen, Inge; Scott, James; Shidhaye, Rahul; Vijayakumar, Lakshmi; Thornicroft, Graham; Whiteford, Harvey

    2016-04-16

    The burden of mental, neurological, and substance use (MNS) disorders increased by 41% between 1990 and 2010 and now accounts for one in every 10 lost years of health globally. This sobering statistic does not take into account the substantial excess mortality associated with these disorders or the social and economic consequences of MNS disorders on affected persons, their caregivers, and society. A wide variety of effective interventions, including drugs, psychological treatments, and social interventions, can prevent and treat MNS disorders. At the population-level platform of service delivery, best practices include legislative measures to restrict access to means of self-harm or suicide and to reduce the availability of and demand for alcohol. At the community-level platform, best practices include life-skills training in schools to build social and emotional competencies. At the health-care-level platform, we identify three delivery channels. Two of these delivery channels are especially relevant from a public health perspective: self-management (eg, web-based psychological therapy for depression and anxiety disorders) and primary care and community outreach (eg, non-specialist health worker delivering psychological and pharmacological management of selected disorders). The third delivery channel, hospital care, which includes specialist services for MNS disorders and first-level hospitals providing other types of services (such as general medicine, HIV, or paediatric care), play an important part for a smaller proportion of cases with severe, refractory, or emergency presentations and for the integration of mental health care in other health-care channels, respectively. The costs of providing a significantly scaled up package of specified cost-effective interventions for prioritised MNS disorders in low-income and lower-middle-income countries is estimated at US$3-4 per head of population per year. Since a substantial proportion of MNS disorders run a chronic and disabling course and adversely affect household welfare, intervention costs should largely be met by government through increased resource allocation and financial protection measures (rather than leaving households to pay out-of-pocket). Moreover, a policy of moving towards universal public finance can also be expected to lead to a far more equitable allocation of public health resources across income groups. Despite this evidence, less than 1% of development assistance for health and government spending on health in low-income and middle-income countries is allocated to the care of people with these disorders. Achieving the health gains associated with prioritised interventions will require not just financial resources, but committed and sustained efforts to address a range of other barriers (such as paucity of human resources, weak governance, and stigma). Ultimately, the goal is to massively increase opportunities for people with MNS disorders to access services without the prospect of discrimination or impoverishment and with the hope of attaining optimal health and social outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Extraction-Separation Performance and Dynamic Modeling of Orion Test Vehicles with Adams Simulation: 3rd Edition

    Science.gov (United States)

    Varela, Jose G.; Reddy, Satish; Moeller, Enrique; Anderson, Keith

    2017-01-01

    NASA's Orion Capsule Parachute Assembly System (CPAS) Project is now in the qualification phase of testing, and the Adams simulation has continued to evolve to model the complex dynamics experienced during the test article extraction and separation phases of flight. The ability to initiate tests near the upper altitude limit of the Orion parachute deployment envelope requires extractions from the aircraft at 35,000 ft-MSL. Engineering development phase testing of the Parachute Test Vehicle (PTV) carried by the Carriage Platform Separation System (CPSS) at altitude resulted in test support equipment hardware failures due to increased energy caused by higher true airspeeds. As a result, hardware modifications became a necessity requiring ground static testing of the textile components to be conducted and a new ground dynamic test of the extraction system to be devised. Force-displacement curves from static tests were incorporated into the Adams simulations, allowing prediction of loads, velocities and margins encountered during both flight and ground dynamic tests. The Adams simulation was then further refined by fine tuning the damping terms to match the peak loads recorded in the ground dynamic tests. The failure observed in flight testing was successfully replicated in ground testing and true safety margins of the textile components were revealed. A multi-loop energy modulator was then incorporated into the system level Adams simulation model and the effect on improving test margins be properly evaluated leading to high confidence ground verification testing of the final design solution.

  18. Construct Validity of the Chinese Version of the Psycho-Educational Profile-3rd Edition (CPEP-3)

    Science.gov (United States)

    Shek, Daniel Tan Lei; Yu, Lu

    2014-01-01

    Objective behavioral assessment of autism spectrum disorder (ASD) in early childhood is essential for guiding appropriate treatment and intervention. In contrast to Western societies, validated measures of ASD are very limited in different Chinese contexts. The present study attempted to examine the construct validity of the Chinese version of…

  19. Organic Structures from Spectra, 3rd Edition (by L. D. Field, S. Sternhell, and J. R. Kalman)

    Science.gov (United States)

    Rosan, Alan M.

    2002-11-01

    This excellent collection can serve as an instructor's resource, a stand-alone guide in a spectroscopic analysis course, or as a supplemental text in physical or organic chemistry. It may, in fact, serve many in the latter capacity. While a careful reading of the book will uncover those inevitable typos (cystein, ionise, volatilise), slip-ups (the IR doublet for anhydrides is not specified), and omissions (cyclohexanone is not included on the list of IR functional groups), these are few. I was more drawn to the direct, utilitarian language, compact explanations, and the considerable range of problems. Neither literature citations nor answers are provided but a list of solutions is available from the authors. While it would have been most helpful to have included an index listing of molecular formulas, the text does provide a short subject index. As a single integrated resource, Organic Structures from Spectra is to be recommended and will certainly become a staple of spectroscopic challenges on my shelf.

  20. Republished: Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities, 3rd edition

    Directory of Open Access Journals (Sweden)

    Vikram Patel

    2016-01-01

    Full Text Available The burden of mental, neurological, and substance use (MNS disorders increased by 41% between 1990 and 2010 and now accounts for one in every 10 lost years of health globally. This sobering statistic does not take into account the substantial excess mortality associated with these disorders or the social and economic consequences of MNS disorders on affected persons, their caregivers, and society. A wide variety of effective interventions, including drugs, psychological treatments, and social interventions, can prevent and treat MNS disorders. At the population-level platform of service delivery, best practices include legislative measures to restrict access to means of self-harm or suicide and to reduce the availability of and demand for alcohol. At the community-level platform, best practices include life-skills training in schools to build social and emotional competencies. At the health-care-level platform, we identify three delivery channels. Two of these delivery channels are especially relevant from a public health perspective: self-management (eg, web-based psychological therapy for depression and anxiety disorders and primary care and community outreach (eg, non-specialist health worker delivering psychological and pharmacological management of selected disorders. The third delivery channel, hospital care, which includes specialist services for MNS disorders and first-level hospitals providing other types of services (such as general medicine, HIV, or paediatric care, play an important part for a smaller proportion of cases with severe, refractory, or emergency presentations and for the integration of mental health care in other health-care channels, respectively. The costs of providing a significantly scaled up package of specified cost-effective interventions for prioritised MNS disorders in low-income and lower-middle-income countries is estimated at US$3-4 per head of population per year. Since a substantial proportion of MNS disorders run a chronic and disabling course and adversely affect household welfare, intervention costs should largely be met by government through increased resource allocation and financial protection measures (rather than leaving households to pay out-of-pocket. Moreover, a policy of moving towards universal public finance can also be expected to lead to a far more equitable allocation of public health resources across income groups. Despite this evidence, less than 1% of development assistance for health and government spending on health in low-income and middle-income countries is allocated to the care of people with these disorders. Achieving the health gains associated with prioritised interventions will require not just financial resources, but committed and sustained efforts to address a range of other barriers (such as paucity of human resources, weak governance, and stigma. Ultimately, the goal is to massively increase opportunities for people with MNS disorders to access services without the prospect of discrimination or impoverishment and with the hope of attaining optimal health and social outcomes.

  1. Near-field optical study of 3rd order nonlinear properties of amorphous silicon

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Jin; Park, J.H.; Kim, M.R.; Jhe, Won Ho [Seoul National University, Seoul (Korea, Republic of); Rhee, B.K. [Sogang University, Seoul (Korea, Republic of)

    1999-07-01

    The 3rd order nonlinear properties show optical bleaching (Saturation) and Reverse saturation in absorption aspect, whereas self-focusing and self-defocusing in refraction aspect. Optical bleaching and self-focusing phenomena of those properties in particular can be useful to make the optical beam spot size smaller for application on the higher optical storage density. In this experiment, amorphous silicon layer is used to investigate the effect of 3rd order nonlinear material(1) on the spot size. The amorphous silicon (A-Si) layer is deposited by the method of PECVD on the corning 1737 fusion glass and its thickness is 300 nm. Two experiments are carried out in this work. One is the far-field Z-Scan and the other is the near-field Z-scan where the laser beam spot is scanned by NSOM in the near field region of the material. The former is for investigating the general 3rd order nonlinear properties of amorphous silicon and the latter is for measuring the change of the beam spot size directly. The far-field Z-scan shows Reverse saturation (Im{chi}{sup (3)} {approx} 8 X 10{sup -3} esu) and self-focusing (Re{chi}{sup (3)} {approx} 2 X 10{sup -2} esu) properties for the A-Si layer. In the second experiment, we present the change the beam spot size as a function of the input beam intensity for the A-Si layer. As a result, we find that the stronger the input beam intensity is, the smaller a beam spot size is obtained for A-Si layer. (author)

  2. Summary of the 3rd workshop on the reduced-moderation water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, Nobuyuki; Nakatsuka, Tohru; Iwamura, Takamichi [eds.

    2000-06-01

    The research activities of a Reduced-Moderation Water Reactor (RMWR) are being performed for a development of the next generation water-cooled reactor. A workshop on the RMWR was held on March 3rd 2000 aiming to exchange information between JAERI and other organizations such as universities, laboratories, utilities and vendors. This report summarizes the contents of lectures and discussions on the workshop. The 1st workshop was held on March 1998 focusing on the review of the research activities and future research plan. The succeeding 2nd workshop was held on March 1999 focusing on the topics of the plutonium utilization in water-cooled reactors. The 3rd workshop was held on March 3rd 2000, which was attended by 77 participants. The workshop began with a lecture titled 'Recent Situation Related to Reduced-Moderation Water Reactor (RMWR)', followed by 'Program on MOX Fuel Utilization in Light Water Reactors' which is the mainstream scenario of plutonium utilization by utilities, and 'Feasibility Studies on Commercialized Fast Breeder Reactor Cycle System' mainly conducted by Japan Nuclear Cycle Development Institute (JNC). Also, following lectures were given as the recent research activities in JAERI: 'Progress in Design Study on Reduced-Moderation Water Reactors', 'Long-Term Scenarios of Power Reactors and Fuel Cycle Development and the Role of Reduced Moderation Water Reactors', 'Experimental and Analytical Study on Thermal Hydraulics' and Reactor Physics Experiment Plan using TCA'. At the end of the workshop, a general discussion was performed about the research and development of the RMWR. This report includes the original papers presented at the workshop and summaries of the questions and answers for each lecture and general discussion, as well as presentation viewgraphs, program and participant list as appendixes. The 7 of the presented papers are indexed individually. (J.P.N.)

  3. 3rd International Conference on Computer Science, Applied Mathematics and Applications

    CERN Document Server

    Nguyen, Ngoc; Do, Tien

    2015-01-01

    This volume contains the extended versions of papers presented at the 3rd International Conference on Computer Science, Applied Mathematics and Applications (ICCSAMA 2015) held on 11-13 May, 2015 in Metz, France. The book contains 5 parts: 1. Mathematical programming and optimization: theory, methods and software, Operational research and decision making, Machine learning, data security, and bioinformatics, Knowledge information system, Software engineering. All chapters in the book discuss theoretical and algorithmic as well as practical issues connected with computation methods & optimization methods for knowledge engineering and machine learning techniques.  

  4. 3rd International Conference on Modelling, Computation and Optimization in Information Systems and Management Sciences

    CERN Document Server

    Dinh, Tao; Nguyen, Ngoc

    2015-01-01

    This proceedings set contains 85 selected full papers presented at the 3rd International Conference on Modelling, Computation and Optimization in Information Systems and Management Sciences - MCO 2015, held on May 11–13, 2015 at Lorraine University, France. The present part I of the 2 volume set includes articles devoted to Combinatorial optimization and applications, DC programming and DCA: thirty years of Developments, Dynamic Optimization, Modelling and Optimization in financial engineering, Multiobjective programming, Numerical Optimization, Spline Approximation and Optimization, as well as Variational Principles and Applications

  5. Resonance-like nuclear processes in solids: 3rd and 4th order processes

    CERN Document Server

    Kálmán, Péter

    2013-01-01

    It is recognized that in the family of heavy charged particle and electron assisted double nuclear processes resonance-like behavior can appear. The transition rates of the heavy particle assisted 3rd-order and electron assisted 4th-order resonance like double nuclear processes are determined. The power of low energy nuclear reactions in $Ni-H$ systems formed in $Ni$ placed in $H_{2}$ gas environment is treated. Nuclear power produced by quasi-resonant electron assisted double nuclear processes in these $Ni-H$ systems is calculated. The power obtained tallies with experiments and its magnitude is considerable for practical applications.

  6. The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics

    Science.gov (United States)

    Evans, Christopher H; Ghivizzani, Steven C; Gouze, Elvire; Rediske, John J; Schwarz, Edward M; Robbins, Paul D

    2005-01-01

    The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics was held in Boston, Massachusetts, USA in May 2004. Keystone lectures delivered by Drs Joseph Glorioso and Inder Verma provided comprehensive, up-to-date information on all major virus vectors. Other invited speakers covered the application of gene therapy to treatment of arthritis, including the latest clinical trial in rheumatoid arthritis, as well as lupus and Sjögren's syndrome. Applications in mesenchymal stem cell biology, tissue repair, and regenerative medicine were also addressed. The field has advanced considerably since the previous meeting in this series, and further clinical trials seem likely. PMID:16277703

  7. Preliminary Location Accuracy Assessments of 3rd Satellite of TH-1

    OpenAIRE

    2016-01-01

    The TH-1 satellite is the first stereo mapping transmission satellite in China, and the primary mission goal of the satellite is for topographic mapping at 1:50 000 scale and high-accuracy location without Ground Control Points (GCPs). 1st, 2nd satellites of TH-1 were launched on August 24, 2010, May 6, 2012, and 3rd satellite was launched on October 26, 2015. Now, three satellites of TH-1 are well operating on its orbit. After evaluation, the location accuracy of 1st satellite without GCPs i...

  8. Virtual Visit to the ATLAS Control Room by 3rd Gymnasium in Volos

    CERN Multimedia

    2013-01-01

    The city of Volos, situated at the centre of the Greek mainland, will be hosting the 7th International Olympiad on Astronomy and Astrophysics this summer. In this context, and with support of PATHWAY and Discover the COSMOS projects, Volos` science education community is organising several pre-events aimed at bringing the world`s biggest experiments in science closer to students - the scientists of tomorrow. Junior high school students from the 3rd Gymnasium in Volos will have the unique opportunity to visit the ATLAS control room on 29th of March.

  9. Field trip guidebook : 3rd international meeting of fire effects on soil properties

    OpenAIRE

    Gonçalves, António Bento; Vieira, António; Leite, Flora Ferreira; Lourenço, Luciano; Botelho, Hermínio; Fernandes, Paulo [UNESP; Úbeda, Xavier; Cerdà, Artémio

    2011-01-01

    The present document is intended to be an auxiliary working instrument for the field trip to the northwest mountains of Portugal, organized during the 3rd International Meeting of Fire Effects on Soil Properties by the Núcleo Investigação em Geografia e Planeamento da Universidade do Minho, with the collaboration of the Centro de Estudos de Geografia e Ordenamento do Território, scheduled for March 15-19, 2011, in the city of Guimarães (Portugal). The trip is programmed for 17 March 2011 a...

  10. 3rd International Symposium on Big Data and Cloud Computing Challenges

    CERN Document Server

    Neelanarayanan, V

    2016-01-01

    This proceedings volume contains selected papers that were presented in the 3rd International Symposium on Big data and Cloud Computing Challenges, 2016 held at VIT University, India on March 10 and 11. New research issues, challenges and opportunities shaping the future agenda in the field of Big Data and Cloud Computing are identified and presented throughout the book, which is intended for researchers, scholars, students, software developers and practitioners working at the forefront in their field. This book acts as a platform for exchanging ideas, setting questions for discussion, and sharing the experience in Big Data and Cloud Computing domain.

  11. 3rd IFToMM Symposium on Mechanism Design for Robotics

    CERN Document Server

    Ceccarelli, Marco

    2015-01-01

    This volume contains the Proceedings of the 3rd IFToMM Symposium on Mechanism Design for Robotics, held in Aalborg, Denmark, 2-4 June, 2015. The book contains papers on recent advances in the design of mechanisms and their robotic applications. It treats the following topics: mechanism design, mechanics of robots, parallel manipulators, actuators and their control, linkage and industrial manipulators, innovative mechanisms/robots and their applications, among others. The book can be used by researchers and engineers in the relevant areas of mechanisms, machines and robotics.

  12. PREFACE: 3rd International Workshop on Materials Analysis and Processing in Magnetic Fields (MAP3)

    Science.gov (United States)

    Sakka, Yoshio; Hirota, Noriyuki; Horii, Shigeru; Ando, Tsutomu

    2009-07-01

    The 3rd International Workshop on Materials Analysis and Processing in Materials Fields (MAP3) was held on 14-16 May 2008 at the University of Tokyo, Japan. The first was held in March 2004 at the National High Magnetic Field Laboratory in Tallahassee, USA. Two years later the second took place in Grenoble, France. MAP3 was held at The University of Tokyo International Symposium, and jointly with MANA Workshop on Materials Processing by External Stimulation, and JSPS CORE Program of Construction of the World Center on Electromagnetic Processing of Materials. At the end of MAP3 it was decided that the next MAP4 will be held in Atlanta, USA in 2010. Processing in magnetic fields is a rapidly expanding research area with a wide range of promising applications in materials science. MAP3 focused on the magnetic field interactions involved in the study and processing of materials in all disciplines ranging from physics to chemistry and biology: Magnetic field effects on chemical, physical, and biological phenomena Magnetic field effects on electrochemical phenomena Magnetic field effects on thermodynamic phenomena Magnetic field effects on hydrodynamic phenomena Magnetic field effects on crystal growth Magnetic processing of materials Diamagnetic levitation Magneto-Archimedes effect Spin chemistry Application of magnetic fields to analytical chemistry Magnetic orientation Control of structure by magnetic fields Magnetic separation and purification Magnetic field-induced phase transitions Materials properties in high magnetic fields Development of NMR and MRI Medical application of magnetic fields Novel magnetic phenomena Physical property measurement by Magnetic fields High magnetic field generation> MAP3 consisted of 84 presentations including 16 invited talks. This volume of Journal of Physics: Conference Series contains the proceeding of MAP3 with 34 papers that provide a scientific record of the topics covered by the conference with the special topics (13 papers) in

  13. [Application progress of CRISPR/Cas9 genome editing technology in the treatment of HIV-1 infection].

    Science.gov (United States)

    Han, Yinglun; Li, Qingwei

    2016-01-01

    The goal of gene therapy is to introduce foreign genes into human target cells in a certain way to correct or compensate diseases caused by defective or abnormal genes. Therefore, gene therapy has great practical significance in studying the treatment of persistent or latent HIV-1 infection. At present, the existing methods of gene therapy have some major defects such as limited target site recognition and high frequency of off-targets. The latest research showed that the clustered regularly interspaced short palindromic repeats (CRISPR) /CRISPR-associated nuclease 9 (Cas9) system from bacteria and archaea has been successfully reformed to a targeted genome editing tool. Thus, how to achieve the goal of treating HIV-1 infection by modifying targeted HIV-1 virus genome effectively using the CRISPR/Cas9 system has become a current research focus. Here we review the latest achievements worldwide and briefly introduce applications of the CRISPR/Cas9 genome editing technology in the treatment of HIV-1 infection, including CCR5 gene editing, removal of HIV-1 virus and activation of HIV-1 virus, in order to provide reference for the prevention and treatment of HIV-1 infection.

  14. 3rd International Conference on Numerical Analysis and Optimization : Theory, Methods, Applications and Technology Transfer

    CERN Document Server

    Grandinetti, Lucio; Purnama, Anton

    2015-01-01

    Presenting the latest findings in the field of numerical analysis and optimization, this volume balances pure research with practical applications of the subject. Accompanied by detailed tables, figures, and examinations of useful software tools, this volume will equip the reader to perform detailed and layered analysis of complex datasets. Many real-world complex problems can be formulated as optimization tasks. Such problems can be characterized as large scale, unconstrained, constrained, non-convex, non-differentiable, and discontinuous, and therefore require adequate computational methods, algorithms, and software tools. These same tools are often employed by researchers working in current IT hot topics such as big data, optimization and other complex numerical algorithms on the cloud, devising special techniques for supercomputing systems. The list of topics covered include, but are not limited to: numerical analysis, numerical optimization, numerical linear algebra, numerical differential equations, opt...

  15. Intelligence and Technology. Joint Force Quarterly, Issue 46, 3rd Quarter 2007

    Science.gov (United States)

    2007-01-01

    biological, or nuclear weapons has made their use rare, but these weapons have been used for terror purposes. Sarin, a chemical nerve agent, was used...increased sharply from the moment of the World Trade Center attack until it reached the anthrax frenzy ” (p. 149). By using fiction and media accounts

  16. Methodologies and Intelligent Systems for Technology Enhanced Learning

    CERN Document Server

    Gennari, Rosella; Vittorini, Pierpaolo; Prieta, Fernando

    2015-01-01

    This volume presents recent research on Methodologies and Intelligent Systems for Technology Enhanced Learning. It contains the contributions of MIS4TEL 2015, which took place in Salamanca, Spain,. On June 3rd to 5th 2015. Like the previous edition, this proceedings and the conference is an open forum for discussing intelligent systems for Technology Enhanced Learning and empirical methodologies for their design or evaluation MIS4TEL’15 conference has been organized by University of L’aquila, Free University of Bozen-Bolzano and the University of Salamanca.  .

  17. Visualization analysis of CRISPR/Cas9 gene editing technology studies

    Institute of Scientific and Technical Information of China (English)

    Quan-sheng DU; Jie CUI; Chun-jie ZHANG; Ke HE

    2016-01-01

    The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system is an adaptive immune defense system that resists the invasion of viruses and plasmids heterologous genetic material in bacteria and archaea. Taking the literature related to gene editing technology of CRISPR/Cas9 from the Web of Science database from 2002 to 2015, we use the software CiteSpaceV to analyze co-cited literature in order to establish the research hotspots and fronts recently in this field by knowledge mapping.%题目:基因编辑技术CRISPR/Cas9研究的可视化分析目的:理解CRISPR/Cas9研究的知识进化路径,以及动态过程和特点。创新点:CRISPR/Cas9系统是细菌和古细菌在长期演化过程中形成的一种抵御异源遗传物质入侵的适应性免疫防御机制。它被广泛应用于人类细胞、小鼠、斑马鱼、大米等的基因定向改造。本研究利用信息可视化软件 CiteSpaceV 分析了近年发表的CRISPR/Cas9有关文献,并绘制了知识图谱。方法:基于Web of Science数据库中2002年至2015年有关基因编辑技术 CRISPR/Cas9的文献资料为研究对象。利用信息可视化软件CiteSpaceV进行共被引文献分析,以知识图谱方式展现该领域近年来的研究热点和前沿。结论:CRISPR/Cas9系统的历史研究充分表明跨学科的重要性。跨学科点通常是新的科学的增长点和新的科学前沿,这是最有可能产生显著科学突破的地方。

  18. 3rd International School of Trigger and Data Acquisition - Cracow (Poland), 1 – 8 February 2012

    CERN Multimedia

    Yi Ling

    2011-01-01

    After two successful editions of the International School of Trigger and Data Acquisition (ISOTDAQ), the ISOTDAQ 2012 is the third of a series of this International School dedicated to introduce MSc and PhD students to the arts and crafts of triggering and acquiring data for physics experiments. The school will be held from 1 – 8 February 2012 in the Cracow University of Technology and Institute of Nuclear Physics, Cracow, Poland.  The school provides an up-to-date overview of the basic instruments and methodologies used in high energy physics, spanning from small experiences in lab to the very large LHC experiments, spotting the main building blocks as well as the different solutions and architectures at different levels of complexity. The main topics of the school include the basics of Data Acquisition (DAQ) programming concepts (e.g. threaded programming, data storage, networking, IO programming), hardware bus systems (VME bus, PCI), Trigger logic and Hardware (NIM). PC based readout...

  19. Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editing.

    Science.gov (United States)

    Nakagawa, Yoshiko; Sakuma, Tetsushi; Nakagata, Naomi; Yamasaki, Sho; Takeda, Naoki; Ohmuraya, Masaki; Yamamoto, Takashi

    2014-01-01

    Reproductive engineering techniques, such as in vitro fertilization (IVF) and cryopreservation of embryos or spermatozoa, are essential for preservation, reproduction, and transportation of genetically engineered mice. However, it has not yet been elucidated whether these techniques can be applied for the generation of genome-edited mice using engineered nucleases such as transcription activator-like effector nucleases (TALENs). Here, we demonstrate the usefulness of frozen oocytes fertilized in vitro using frozen sperm for TALEN-mediated genome editing in mice. We examined side-by-side comparisons concerning sperm (fresh vs. frozen), fertilization method (mating vs. IVF), and fertilized oocytes (fresh vs. frozen) for the source of oocytes used for TALEN injection; we found that fertilized oocytes created under all tested conditions were applicable for TALEN-mediated mutagenesis. In addition, we investigated whether the ages in weeks of parental female mice can affect the efficiency of gene modification, by comparing 5-week-old and 8-12-week-old mice as the source of oocytes used for TALEN injection. The genome editing efficiency of an endogenous gene was consistently 95-100% when either 5-week-old or 8-12-week-old mice were used with or without freezing the oocytes. Thus, our report describes the availability of freeze-thawed oocytes and oocytes from female mice at various weeks of age for TALEN-mediated genome editing, thus boosting the convenience of such innovative gene targeting strategies.

  20. Guest Editorial Special Edition ‘Creative Cut’ The International Journal of Fashion Design, Technology and Education

    OpenAIRE

    Almond, Kevin

    2013-01-01

    The call for papers for this special edition ‘Creative Cut’ evolved from a peer reviewed paper entitled ‘Insufficient Allure: The luxury and cost of creative pattern cutting’ published in ‘The International Journal of Fashion Design, Technology and Education’ in 2010. The paper built upon a limited amount of enquiry (British Fashion Council 2000, Fischer 2008, Joseph-Armstrong 2008). It suggests that the role of the creative pattern cutter is an interpretation of the designer’s vision and the...

  1. Improving livestock for agriculture - technological progress from random transgenesis to precision genome editing heralds a new era.

    Science.gov (United States)

    Laible, Götz; Wei, Jingwei; Wagner, Stefan

    2015-01-01

    Humans have a long history in shaping the genetic makeup of livestock to optimize production and meet growing human demands for food and other animal products. Until recently, this has only been possible through traditional breeding and selection, which is a painstakingly slow process of accumulating incremental gains over a long period. The development of transgenic livestock technology offers a more direct approach with the possibility for making genetic improvements with greater impact and within a single generation. However, initially the technology was hampered by technical difficulties and limitations, which have now largely been overcome by progressive improvements over the past 30 years. Particularly, the advent of genome editing in combination with homologous recombination has added a new level of efficiency and precision that holds much promise for the genetic improvement of livestock using the increasing knowledge of the phenotypic impact of genetic sequence variants. So far not a single line of transgenic livestock has gained approval for commercialization. The step change to genome-edited livestock with precise sequence changes may accelerate the path to market, provided applications of this new technology for agriculture can deliver, in addition to economic incentives for producers, also compelling benefits for animals, consumers, and the environment.

  2. Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Peter Gee

    2017-01-01

    Full Text Available In the past decade, the development of two innovative technologies, namely, induced pluripotent stem cells (iPSCs and the CRISPR Cas9 system, has enabled researchers to model diseases derived from patient cells and precisely edit DNA sequences of interest, respectively. In particular, Duchenne muscular dystrophy (DMD has been an exemplary monogenic disease model for combining these technologies to demonstrate that genome editing can correct genetic mutations in DMD patient-derived iPSCs. DMD is an X-linked genetic disorder caused by mutations that disrupt the open reading frame of the dystrophin gene, which plays a critical role in stabilizing muscle cells during contraction and relaxation. The CRISPR Cas9 system has been shown to be capable of targeting the dystrophin gene and rescuing its expression in in vitro patient-derived iPSCs and in vivo DMD mouse models. In this review, we highlight recent advances made using the CRISPR Cas9 system to correct genetic mutations and discuss how emerging CRISPR technologies and iPSCs in a combined platform can play a role in bringing a therapy for DMD closer to the clinic.

  3. Extreme and Local 3rd Harmonic Response of Niobium (Nb) Superconductor

    Science.gov (United States)

    Oripov, Bakhrom; Tai, Tamin; Anlage, Steven

    Superconducting Radio Frequency (SRF) cavities are being widely used in new generation particle accelerators. These SRF cavities are based on bulk Nb. Based on the needs of the SRF community to identify defects on Nb surfaces, a novel near-field magnetic microwave microscope was successfully built using a magnetic writer from a conventional magnetic recording hard-disk drive1. This magnetic writer can create an RF magnetic field, localized and strong enough to drive Nb into the vortex state. This probe enables us to locate defects through scanning and mapping of the local electrodynamic response in the multi-GHz frequency range. Recent measurements have shown that 3rd harmonic nonlinear response is far more sensitive to variations in input power and temperature then linear response, thus we mainly study the 3rd harmonic response. Moreover, the superconductor is usually the only source for nonlinear response in our setup, thus there is less chance of having noise or background signal. Understanding the mechanism responsible for this non-linear response is important for improving the performance of SRF cavities. Besides Nb we also study various other superconductors such as MgB2 and the cuprate Bi-Sr-Ca-Cu-O (BSCCO) for potential applications in SRF cavities. This work is funded by US Department of Energy through Grant # DE-SC0012036T and CNAM.

  4. Formal faculty observation and assessment of bedside skills for 3rd-year neurology clerks.

    Science.gov (United States)

    Thompson Stone, Robert; Mooney, Christopher; Wexler, Erika; Mink, Jonathan; Post, Jennifer; Jozefowicz, Ralph F

    2016-11-22

    To evaluate the feasibility and utility of instituting a formalized bedside skills evaluation (BSE) for 3rd-year medical students on the neurology clerkship. A neurologic BSE was developed for 3rd(-)year neurology clerks at the University of Rochester for the 2012-2014 academic years. Faculty directly observed 189 students completing a full history and neurologic examination on real inpatients. Mock grades were calculated utilizing the BSE in the final grade, and number of students with a grade difference was determined when compared to true grade. Correlation was explored between the BSE and clinical scores, National Board of Medical Examiners (NBME) scores, case complexity, and true final grades. A survey was administered to students to assess their clinical skills exposure and the usefulness of the BSE. Faculty completed and submitted a BSE form for 88.3% of students. There was a mock final grade change for 13.2% of students. Correlation coefficients between BSE score and clinical score/NBME score were 0.36 and 0.35, respectively. A statistically significant effect of BSE was found on final clerkship grade (F2,186 = 31.9, p neurology clerkship was feasible. Low correlation between BSE score and other evaluations indicated a unique measurement to contribute to student grade. Using real patients with differing case complexity did not alter the grade. © 2016 American Academy of Neurology.

  5. Orthotics, prosthesis and mobility aids (OPM dispensation in the Regional Health Department of the 3RD Region of Sao Paulo State

    Directory of Open Access Journals (Sweden)

    Camila Caminha Caro

    2014-12-01

    Full Text Available Objective: To identify the process of dispensation of orthotics, prostheses and mobility aids (OPM by the Unified Health System (SUS in the Regional Health Department of the 3rd Region (DRSIII of Sao Paulo state; perform a mapping of the existing physical rehabilitation services in that region; and subsequently correlate the data with applicable laws. Methodology: This is an exploratory cross-sectional qualitative study whose subjects were the main professionals involved in the process of OPM dispensation, or responsible for their acquisition flow in the cities of that region. Data collection was carried out through a semi-structured questionnaire, developed by the researchers themselves, composed of questions aiming to identify the physical rehabilitation centers in the towns, the staff members involved, the provision of assistive technology through SUS, delivery time and existence of waiting lists. Results and discussion: The data were statistically measured, categorized, described and correlated with the current legislation aimed to guarantee access to assistive technology. We observed that the practice around this resource in the 3rd region concentrates in a single care center, causing long waits and poor efficiency of the services provided, in addition to maintaining a paternalistic aspect. Conclusion: This study provides evidence that, although the right to access to assistive technology is legally guaranteed, there are still many difficulties and challenges around this practice.

  6. Computer Access in Higher Education for Students with Disabilities: A Practical Guide to the Selection and Use of Adapted Computer Technology. Second Edition.

    Science.gov (United States)

    Brown, Carl; And Others

    The manual provides a review of trends in adapted computer technology as well as guidelines to the selection and use of computer technology in college programs serving disabled students. Changes in the second edition include a new section dealing with the computer access needs of the severely disabled, an enlarged product guide, a curriculum guide…

  7. PREFACE: Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors

    Science.gov (United States)

    Granados, Xavier; Sánchez, Àlvar; López-López, Josep

    2012-10-01

    The development of superconducting applications and superconducting engineering requires the support of consistent tools which can provide models for obtaining a good understanding of the behaviour of the systems and predict novel features. These models aim to compute the behaviour of the superconducting systems, design superconducting devices and systems, and understand and test the behavior of the superconducting parts. 50 years ago, in 1962, Charles Bean provided the superconducting community with a model efficient enough to allow the computation of the response of a superconductor to external magnetic fields and currents flowing through in an understandable way: the so called critical-state model. Since then, in addition to the pioneering critical-state approach, other tools have been devised for designing operative superconducting systems, allowing integration of the superconducting design in nearly standard electromagnetic computer-aided design systems by modelling the superconducting parts with consideration of time-dependent processes. In April 2012, Barcelona hosted the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors (HTS), the third in a series of workshops started in Lausanne in 2010 and followed by Cambridge in 2011. The workshop reflected the state-of-the-art and the new initiatives of HTS modelling, considering mathematical, physical and technological aspects within a wide and interdisciplinary scope. Superconductor Science and Technology is now publishing a selection of papers from the workshop which have been selected for their high quality. The selection comprises seven papers covering mathematical, physical and technological topics which contribute to an improvement in the development of procedures, understanding of phenomena and development of applications. We hope that they provide a perspective on the relevance and growth that the modelling of HTS superconductors has achieved in the past 25 years.

  8. 新型基因组编辑技术研究进展%Progress on Novel Genome Editing Technologies

    Institute of Scientific and Technical Information of China (English)

    韩勇; 杨杰; 李子彬; 董宋鹏; 高凤山

    2015-01-01

    Genome editing is a new technology which can modifiy the targeted biological genome accurately so as to knock out some genes site-directly and integrate some exogenous genes site-directly.Recently,sev-eral effective tools were developed quickly,including engineered nuclease mediated zinc-finger nucleases (ZFN),transcription activator-like effector nucleases (TALEN)and clustered regularly interspaced short palindromic repeats along with cas9 protein (CRISPRs/Cas9),and they all can site-directly edit genomes by recognizing the target sites according to the specific structure followed by nuclease cleavage.The three no-vel genome editing technologies have been applied broadly in life science because of their advantages of higher efficiency,making easily and timesaving.Here the characteristics,principles,construction methods of the three novel genome editing technologies and their application in conventional biology model,functional genome screening,and gene therapy for human inherited diseases were reviewed.%基因组编辑技术是一种能精确靶向修饰生物基因组,实现对基因定点敲除和外源基因定点整合的技术。新出现的锌指核酸酶(ZFN)、转录激活子样效应因子核酸酶(TALEN)和规律性重复短回文序列簇与 Cas9蛋白(CRISPRs/Cas9)系统3种新型的基因组编辑技术通过特异性结构识别靶位点,核酸酶发挥切割作用对靶位点进行定点编辑。3种新型基因编辑技术因具有高效准确、制作简单、耗时短等特点而在生命科学研究中得到广泛应用。论文对目前三种新型的基因组定点编辑技术的特点、结构原理、构建方法以及在传统生物模型、功能基因筛选、人类遗传病基因治疗等方面中的应用做一综述。

  9. Application of Oocyte Cryopreservation Technology in TALEN-Mediated Mouse Genome Editing

    OpenAIRE

    Nakagawa, Yoshiko; Sakuma, Tetsushi; Nakagata, Naomi; Yamasaki, Sho; Takeda, Naoki; Ohmuraya, Masaki; Yamamoto, Takashi

    2014-01-01

    Reproductive engineering techniques, such as in vitro fertilization (IVF) and cryopreservation of embryos or spermatozoa, are essential for preservation, reproduction, and transportation of genetically engineered mice. However, it has not yet been elucidated whether these techniques can be applied for the generation of genome-edited mice using engineered nucleases such as transcription activator-like effector nucleases (TALENs). Here, we demonstrate the usefulness of frozen oocytes fertilized...

  10. 3rd International Conference on Modelling and Management of Engineering Processes

    CERN Document Server

    Gericke, Kilian; Szélig, Nikoletta; Vajna, Sándor

    2015-01-01

    Innovative processes for the development of products and services are more and more considered as an organisational capability, which is recognised to be increasingly important for business success in today’s competitive environment. However, management and academia need a more profound understanding of these processes in order to develop improved management approaches to exploit business potentials. This book contains the proceedings of the 3rd International Conference on Modelling and Management of Engineering Processes (MMEP2013) held in Magdeburg, Germany, in November 2013. It includes contributions from international leading researchers in the fields of process modelling and process management. The conference topics were recent trends in modelling and management of engineering processes, potential synergies between different modelling approaches, future challenges for the management of engineering processes as well as future research in these areas.

  11. The Perception of Entrepreneurial and 3rd Generation University in Turkey

    Directory of Open Access Journals (Sweden)

    Deniz Zungun

    2016-07-01

    Full Text Available Increased competition caused by globalization has led to philosophical changes in private and public businesses. This situation has affected educational institutions and they have needed dynamic, innovator and transformational tools in order to survive in competitive environment. The universities defined as �3rd Generation Universities� need commercialization, network among universities, close co-operation among institutions and entrepreneurship as well as intellectual and innovative changes. In this regard, the aim of the research is formed by the analysis of �Entrepreneur University� concept from the perspective of the academicians that served at managerial positions at the universities in Turkey. The research is limited to the opinions of the academicians that served at top, middle and lower management at randomly chosen 20 universities.

  12. Idaho National Laboratory Quarterly Occurrence Analysis - 3rd Quarter FY-2016

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth Ann [Idaho National Laboratory

    2016-09-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (23 from the 3rd Qtr FY-16 and 50 from the prior three reporting quarters), as well as 45 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (16 from this quarter and 29 from the prior three quarters).

  13. Passive solar progress: a simplified guide to the 3rd national passive solar conference

    Energy Technology Data Exchange (ETDEWEB)

    Miller, H.; Howell, Y.; Richards, D.

    1980-10-01

    Some of the concepts and practices that have come to be known as passive solar heating and cooling are introduced, and a current picture of the field is presented. Much of the material presented is derived from papers given at the 3rd National Passive Solar Conference held in San Jose, California in January 1979 and sponsored by the US Department of Energy. Extracts and data from these papers have been integrated in the text with explanatory and descriptive material. In this way, it is attempted to present technical information in an introductory context. Topics include design considerations, passive and hybrid systems and applications, sizing methods and performance prediction, and implementation issues. A glossary is included. (WHK)

  14. Analysis of Coherence Properties of 3-rd Generation Synchrotron Sources and Free-Electron Lasers

    CERN Document Server

    Vartanyants, I A

    2009-01-01

    A general theoretical approach based on the results of statistical optics is used for the analysis of the transverse coherence properties of 3-rd generation synchrotron sources and x-ray free-electron lasers (XFEL). Correlation properties of the wavefields are calculated at different distances from an equivalent Gaussian Schell-model source. This model is used to describe coherence properties of the five meter undulator source at the synchrotron storage ring PETRA III. In the case of XFEL sources the decomposition of the statistical fields into a sum of independently propagating transverse modes is used for the analysis of the coherence properties of these new sources. A detailed calculation is performed for the parameters of the SASE1 undulator at the European XFEL. It is demonstrated that only a few modes contribute significantly to the total radiation field of that source.

  15. Summary of the 3rd workshop on human resources development (HRD) in FNCA. FY2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The Human Resources Development (HRD) Project was added in 1999 to the Cooperation Activities of 'the Forum for Nuclear Cooperation in Asia (FNCA)' which is organized by AEC of Japan. The HRD Project supports to solidify the foundation of nuclear development utilization in Asia by promoting human resources development in Asian countries. The principal activity of the HRD Project is to hold the Workshop on Human Resources Development in the Nuclear Field in Asia once a year. The objective of the Workshop is to clarify problems and needs of the human resources development of each country and to support mutually by exchanging information etc. The report consists of the summary of the 3rd Workshop on Human Resources Development in the Nuclear Field in Asia held on October 29 - November 1, 2001 at the Nuclear Training Center of the Korea Atomic Energy Research Institute in Daejeon, Korea. (author)

  16. Nonlinear Dynamics of Memristor Based 2nd and 3rd Order Oscillators

    KAUST Repository

    Talukdar, Abdul Hafiz

    2011-05-01

    Exceptional behaviours of Memristor are illustrated in Memristor based second order (Wien oscillator) and third order (phase shift oscillator) oscillator systems in this Thesis. Conventional concepts about sustained oscillation have been argued by demonstrating the possibility of sustained oscillation with oscillating resistance and dynamic poles. Mathematical models are also proposed for analysis and simulations have been presented to support the surprising characteristics of the Memristor based oscillator systems. This thesis also describes a comparative study among the Wien family oscillators with one Memristor. In case of phase shift oscillator, one Memristor and three Memristors systems are illustrated and compared to generalize the nonlinear dynamics observed for both 2nd order and 3rd order system. Detail explanations are provided with analytical models to simplify the unconventional properties of Memristor based oscillatory systems.

  17. Relation between physical activity and academic performance in 3rd-year secondary education students.

    Science.gov (United States)

    Morales, José; Pellicer-Chenoll, Maite; García-Masso, Xavier; Gomis, Manuel; González, Luis-Millán

    2011-10-01

    The main aim of this study was to analyze the relationship between the amount of physical activity and academic performance in 3rd-year secondary education students. The sample was taken from three secondary schools in the area of Barcelona. 284 students (158 girls, 126 boys) with an average age of 14.7 yr. participated. The International Physical Activity Questionnaire was used by students to self-report their amount of physical activity. Students' academic records were obtained for comparisons. Results showed that there was a linear relationship between academic performance and physical activity; nevertheless, there was a trend to stronger correlation when modeling the relationship between these variables with a quadratic equation. Further research should focus on whether academic performance and physical activity might be better explained with a second-order equation.

  18. 3rd Sino-German Conference “Underground Storage of CO2 and Energy”

    CERN Document Server

    Xie, Heping; Were, Patrick

    2013-01-01

    Anthropogenic greenhouse gas emissions, energy security and sustainability are three of the greatest contemporary global challenges today. This year the Sino-German Cooperation Group “Underground Storage of CO2 and Energy”, is meeting on the 21-23 May 2013 for the second time in Goslar, Germany, to convene its 3rd Sino-German conference on the theme “Clean Energy Systems in the Subsurface: Production, Storage and Conversion”.   This volume is a collection of diverse quality scientific works from different perspectives elucidating on the current developments in CO2 geologic sequestration research to reduce greenhouse emissions including measures to monitor surface leakage, groundwater quality and the integrity of caprock, while ensuring a sufficient supply of clean energy. The contributions herein have been structured into 6 major thematic research themes: Integrated Energy and Environmental Utilization of Geo-reservoirs: Law, Risk Management & Monitoring CO2 for Enhanced Gas and Oil Recovery, Coa...

  19. 3rd International Summer School Nanotechnology : From Fundamental Research to Innovations

    CERN Document Server

    Yatsenko, Leonid

    2015-01-01

    This book highlights the most recent advances in nanoscience from leading researchers in Ukraine, Europe, and beyond.  It features contributions from participants of the 3rd International Summer School “Nanotechnology: From Fundamental Research to Innovations,” held in Yaremche, Ukraine on August 23-26, 2014 and of the 2nd International NANO-2014 Conference, held in Lviv, Ukraine on August 27-30, 2014.  These events took place within the framework of the European Commission FP7 project Nanotwinning, and were organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), University of Turin (Italy), and Pierre and Marie Curie University (France).  Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results in the areas of nanocomposites and nanomaterials, nanostructured surfaces, microscopy of nano-objects, nano-optics and nanophotonics, nanoplasmonics, nanochemistry, na...

  20. Meeting Report: 3rd International Workshop on Insulin & Cancer Heidelberg, Germany, October 30-31, 2010

    Directory of Open Access Journals (Sweden)

    Chantelau Ernst

    2010-12-01

    Full Text Available Abstract The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany. The topics followed-up the discussions of the previous workshops: possible differences in mitogenicity between natural insulin and genetically engineered insulin derivatives (insulin analogues, as shown by laboratory studies and epidemiologic studies alike; molecular studies on the links between metabolic and mitogenic effects of insulin, and of hyperinsulinaemia in particular; epidemiologic evidence of interferences between insulin and other hormones, particularly sex hormones, and obesity-associated cancer; the involvement of inflammatory cytokines produced by fat tissue in obesity-associated cancer; aspects of drug-design (binding drugs to albumin and, last but not least, detection and investigation of circulating cancer cells.

  1. Meeting report: 3rd international workshop on insulin & cancer heidelberg, Germany, october 30-31, 2010.

    Science.gov (United States)

    Chantelau, Ernst; Mayer, Doris

    2010-01-01

    The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany. The topics followed-up the discussions of the previous workshops: possible differences in mitogenicity between natural insulin and genetically engineered insulin derivatives (insulin analogues), as shown by laboratory studies and epidemiologic studies alike; molecular studies on the links between metabolic and mitogenic effects of insulin, and of hyperinsulinaemia in particular; epidemiologic evidence of interferences between insulin and other hormones, particularly sex hormones, and obesity-associated cancer; the involvement of inflammatory cytokines produced by fat tissue in obesity-associated cancer; aspects of drug-design (binding drugs to albumin) and, last but not least, detection and investigation of circulating cancer cells.

  2. Retrospective Dosimetry of Vver 440 Reactor Pressure Vessel at the 3RD Unit of Dukovany Npp

    Science.gov (United States)

    Marek, M.; Viererbl, L.; Sus, F.; Klupak, V.; Rataj, J.; Hogel, J.

    2009-08-01

    Reactor pressure vessel (RPV) residual lifetime of the Czech VVER-440 is currently monitored under Surveillance Specimens Programs (SSP) focused on reactor pressure vessel materials. Neutron fluence in the samples and its distribution in the RPV are determined by a combination of calculation results and the experimental data coming from the reactor dosimetry measurements both in the specimen containers and in the reactor cavity. The direct experimental assessment of the neutron flux density incident onto RPV and neutron fluence for the entire period of nuclear power plant unit operation can be based on the evaluation of the samples taken from the inner RPV cladding. The Retrospective Dosimetry was also used at Dukovany NPP at its 3rd unit after the 18th cycle. The paper describes methodology, experimental setup for sample extraction, measurement of activities, and the determination of the neutron flux and fluence averaged over the samples.

  3. 0.5V 3rd-order Tunable gm-C Filter

    Directory of Open Access Journals (Sweden)

    R. Arya

    2013-04-01

    Full Text Available This paper proposes a 3rd-order gm-C filter that operates with the extremely low voltage supply of 0.5V. The employed transconductor is capable for operating in an extremely low voltage power supply environment. A benefit offered by the employed transconductor is that the filter’s cut-off frequency can be tuned, through a dc control current, for relatively large ranges. The filter structure was designed using normal threshold transistors of a triple-well 0.13μm CMOS process and is operated under a 0.5V supply voltage; its behavior has been evaluated through simulation results by utilizing the Analog Design Environment of the Cadence software.

  4. Virtual Visit to the ATLAS Control Room by 1st and 3rd Lyceums in Chios

    CERN Multimedia

    2013-01-01

    High school students from the 1st and 3rd Lyceums of Chios, Greece, will be visiting the control room of ATLAS to discuss the latest results on the Higgs search, LHC’s first long shutdown and what the future holds for the ATLAS experiment. This visit takes place in the context of a Masterclass where students will learn how to analyse real events from the LHC with the use of the HYPATIA online applet based on educational scenarios from the Discover the COSMOS portal. This full-day activity is organized by the University of Athens, the University of the Aegean, Ellinogermaniki Agogi and the Chios Physical Society in the framework of the Open Discovery Space EU project.

  5. Interviews with Michael Baxandall, February 3rd and 4th, 1994, Berkeley, CA

    Directory of Open Access Journals (Sweden)

    Allan Langdale

    2009-12-01

    Full Text Available The following interviews with Michael Baxandall were conducted in Berkeley on February 3rd and 4th of 1994. The content of these interviews include general responses about developments in art history in the years between 1960 and 1985, a period of dramatic modifications in the discipline. Among the issues are the rise of the social history of art and the sources from anthropology that informed Baxandall’s concept of the ‘Period Eye’. Baxandall talks about his own work, his personal intellectual history, and the scholars of past and current generations who influenced him. Other topics include Baxandall’s professional trajectory, the Warburg Library, and aspects of cultural history having to do with Renaissance Humanism. These interviews first appeared as an appendix to the PhD dissertation by Allan Langdale, Art History and Intellectual History: Michael Baxandall’s Work between 1963 and 1985, U. C. Santa Barbara, 1995.

  6. Type division and controlling factor analysis of 3rd-order sequences in marine carbonate rocks

    Directory of Open Access Journals (Sweden)

    Yunbo Zhang

    2014-03-01

    Full Text Available Type division and controlling factor analysis of 3rd-order sequence are of practical significance to tectonic analysis, sedimentary environment identification, and other geological researches. Based on the comprehensive analysis of carbon and oxygen isotope trends, paleobathymetry and spectral-frequency of representative well logs, 3rd-order sequences can be divided into 3 types: (a global sea level (GSL sequence mainly controlled by GSL change; (b tectonic sequence mainly controlled by regional tectonic activity; and (c composite sequence jointly controlled by GSL change and regional tectonic activity. This study aims to identify the controlling factors of 3rd-order sequences and to illustrate a new method for classification of 3rd-order sequences of the middle Permian strata in the Sichuan Basin, China. The middle Permian strata in the Sichuan Basin consist of 3 basin-contrastive 3rd-order sequences, i.e., PSQ1, PSQ2 and PSQ3. Of these, PSQ1 is a GSL sequence while PSQ2 and PSQ3 are composite sequences. The results suggest that the depositional environment was stable during the deposition of PSQ1, but was activated by tectonic activity during the deposition of the middle Permian Maokou Formation.

  7. Specific Destruction of HIV Proviral p17 Gene in T Lymphoid Cells Achieved by the Genome Editing Technology.

    Science.gov (United States)

    Kishida, Tsunao; Ejima, Akika; Mazda, Osam

    2016-01-01

    Recent development in genome editing technologies has enabled site-directed deprivation of a nucleotide sequence in the chromosome in mammalian cells. Human immunodeficiency (HIV) infection causes integration of proviral DNA into the chromosome, which potentially leads to re-emergence of the virus, but conventional treatment cannot delete the proviral DNA sequence from the cells infected with HIV. In the present study, the transcription activator-like effector nucleases (TALENs) specific for the HIV p17 gene were constructed, and their activities to destroy the target sequence were evaluated. SSA assay showed a high activity of a pair of p17-specific TALENs. A human T lymphoid cell line, Jurkat, was infected with a lentivirus vector followed by transfection with the TALEN-HIV by electroporation. The target sequence was destructed in approximately 10-95% of the p17 polymerase chain reaction clones, and the efficiencies depended on the Jurkat-HIV clones. Because p17 plays essential roles for assembly and budding of HIV, and this gene has relatively low nucleotide sequence diversity, genome editing procedures targeting p17 may provide a therapeutic benefit for HIV infection.

  8. [The application of CRISPR-Cas9 gene editing technology in viral infection diseases].

    Science.gov (United States)

    Lijuan, Yin; Siqi, Hu; Fei, Guo

    2015-05-01

    The RNA-guided Cas9 nuclease from microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system has been used to facilitate efficient genome engineering in eukaryotic cells. The specific targeted genome is recognized and cut by gRNA-directed CRISPR/Cas9 complex, specifically by the endonuclease Cas9. The targeted gene locus could be repaired either by homology-directed repair or nonhomologous end joining, thus achieving a desired editing outcome. Viruses infect cells through specific receptors, and then the viral genome is transcribed, replicated and translated to complete its life cycle. As a result, some DNA virus and retrovirus genomes are integrated into the cellular genome. Gene therapy is a new trend to treat viral infected diseases. Given its designable sequence-specific editing of the targeted genome, CRISPR/Cas9 has tremendous potential in treating persistent and latent viral infections. In this review, we summarize the mechanism and progresses of CRISPR/Cas9, and also highlight its therapeutic application in infectious diseases.

  9. Additional circular intercostal space created by bifurcation of the left 3rd rib and its costal cartilage: a case report.

    Science.gov (United States)

    Kumar, Naveen; Guru, Anitha; Patil, Jyothsna; Ravindra, Swamy; Badagabettu, Satheesha Nayak

    2013-01-08

    In the thorax there are normally 11 pairs of intercostal spaces: the spaces between adjacent ribs. The intercostal spaces contain intercostal muscles, intercostal nerves and vessels. During a routine dissection for undergraduate medical students, we observed a variation involving the left 3rd rib and 3rd costal cartilage in the cadaver of a man of Indian ethnicity aged about 65 years. The left 3rd rib and its costal cartilage were bifurcated at their costochondral junction enclosing a small circular additional intercostal space. Muscle tissue covered by deep fascia was present in this circular intercostal space. The muscle in the circular intercostal space received its nerve supply from a branch of the 2nd intercostal nerve. Knowledge of such variations is helpful to surgeons operating on the anterior thoracic wall involving ribs and intercostal spaces. Knowing the possibility of the presence of an additional space between normal intercostal spaces can guide a surgeon through to a successful surgery.

  10. Efficacy of a 3rd generation high-throughput sequencing platform for analyses of 16S rRNA genes from environmental samples.

    Science.gov (United States)

    Mosher, Jennifer J; Bernberg, Erin L; Shevchenko, Olga; Kan, Jinjun; Kaplan, Louis A

    2013-11-01

    Longer sequences of the bacterial 16S rRNA gene could provide greater phylogenetic and taxonomic resolutions and advance knowledge of population dynamics within complex natural communities. We assessed the accuracy of a Pacific Biosciences (PacBio) single molecule, real time (SMRT) sequencing based on DNA polymerization, a promising 3rd generation high-throughput technique, and compared this to the 2nd generation Roche 454 pyrosequencing platform. Amplicons of the 16S rRNA gene from a known isolate, Shewanella oneidensis MR1, and environmental samples from two streambed habitats, rocks and sediments, and a riparian zone soil, were analyzed. On the PacBio we analyzed ~500 bp amplicons that covered the V1-V3 regions and the full 1500 bp amplicons of the V1-V9 regions. On the Roche 454 we analyzed the ~500 bp amplicons. Error rates associated with the isolate were lowest with the Roche 454 method (2%), increased by more than 2-fold for the 500 bp amplicons with the PacBio SMRT chip (4-5%), and by more than 8-fold for the full gene with the PacBio SMRT chip (17-18%). Higher error rates with the PacBio SMRT chip artificially inflated estimates of richness and lowered estimates of coverage for environmental samples. The 3rd generation sequencing technology we evaluated does not provide greater phylogenetic and taxonomic resolutions for studies of microbial ecology. © 2013.

  11. On the Generalisation of Kepler's 3rd Law for the Vacuum Field of the Point-Mass

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2005-07-01

    Full Text Available I derive herein a general form of Kepler’s 3rd Law for the general solution to Einstein’s vacuum field. I also obtain stable orbits for photons in all the configurations of the point-mass. Contrary to the accepted theory, Kepler’s 3rd Law is modified by General Relativity and leads to a finite angular velocity as the proper radius of the orbit goes down to zero, without the formation of a black hole. Finally, I generalise the expression for the potential function of the general solution for the point-mass in the weak field.

  12. On the Generalisation of Kepler's 3rd Law for the Vacuum Field of the Point-Mass

    OpenAIRE

    Crothers S. J.

    2005-01-01

    I derive herein a general form of Kepler’s 3rd Law for the general solution to Einstein’s vacuum field. I also obtain stable orbits for photons in all the configurations of the point-mass. Contrary to the accepted theory, Kepler’s 3rd Law is modified by General Relativity and leads to a finite angular velocity as the proper radius of the orbit goes down to zero, without the formation of a black hole. Finally, I generalise the expression for the potential function of the general solution for t...

  13. 3rd International Conference of Open and Distance Learning (ICODL 2005 held in Patra, Greece

    Directory of Open Access Journals (Sweden)

    3rd International Conference of Open and Distance Learning (ICODL 2005 held in Patra, Greece

    2006-01-01

    Full Text Available NOTE FOR TOJDE EDITOR 3rd International Conference of Open and Distance Learning (ICODL 2005 held in Patra, Greece Dear Friends and Tojde Readers, First of all I would like to thank very much those who participated in the 3rd International Conference of Open and Distance Learning (ICODL 2005 in Patra, Greece. Those who couldn't come, I hope to meet them some time in the future. I personally want to give my thanks to all who sent their papers for the Conference and trusted us for the organization of the Conference and our involvement in Open and Distance Learning. In total, the 3 days of the Conference there were 620 people (registered who attended the presentations and panels and about 70 people. The proceedings of the Conference are in two volumes; Volume A (pages 686 and Volume B (pages 592. All those presentations (names and titles which are in the final programme (see http://artemis.eap.gr/icodl2005 are included in the proceedings. I must inform you that the majority of the papers are in Greek. I haven't counted the English language papers, but I presume that they must be around 40. The success of the ICODL 2005 is already leading us to the preparation of the next conference which - I believe - will take place in Athens in the year 2007. I will keep you informed for our plans. At the same time the Hellenic Network of Open and Distance Education (H-NODE in cooperation with the 'Propobos Publishing Company' has published the second issue of the Journal 'Open Education'. If you want information about the Journal you can contact 'Propobos Publishing Company': E-mail propobos@propobos.gr. The H-NODE in cooperation with the Department of Education - University of Crete is also organizing a "Summer School" in the town of Rethymnon (Crete in July 2006 (16-23. The "Summer School" will take place in the campus which is by the sea and will be only in Greek. Last year we had organized a similar "Summer School" in the island of Kefalonia, in the west

  14. A critical experimental test of synchrotron radiation theory with 3rd generation light source

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca [European XFEL GmbH, Hamburg (Germany); Kocharyan, Vitali; Saldin, Evgeni [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2016-05-15

    A recent ''beam splitting'' experiment at LCLS apparently demonstrated that after a microbunched electron beam is kicked on a large angle compared to the divergence of the FEL radiation, the microbunching wave front is readjusted along the new direction of motion of the kicked beam. Therefore, coherent radiation from an undulator placed after the kicker is emitted along the kicked direction without suppression. This strong emission of coherent undulator radiation in the kicked direction cannot be explained in the framework of conventional synchrotron radiation theory. In a previous paper we explained this puzzle. We demonstrated that, in accelerator physics, the coupling of fields and particles is based, on the one hand, on the use of results from particle dynamics treated according to the absolute time convention and, on the other hand, on the use of Maxwell equations treated according to the standard (Einstein) synchronization convention. Here lies the misconception which led to the strong qualitative disagreement between theory and experiment. After the ''beam splitting'' experiment at LCLS, it became clear that the conventional theory of synchrotron radiation cannot ensure the correct description of coherent and spontaneous emission from a kicked electron beam, nor the emission from a beam with finite angular divergence, in an undulator or a bending magnet. However, this result requires further experimental confirmation. In this publication we propose an uncomplicated and inexpensive experiment to test synchrotron radiation theory at 3rd generation light sources.

  15. SESAME-A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    Winick, Herman

    2010-02-01

    Developed under the auspices of UNESCO and modeled on CERN, SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) is an international research center in construction in Jordan. It will enable world class research by scientists from the region, reversing the brain drain. It will also build bridges between diverse societies, contributing to a culture of peace through international cooperation in science. The centerpiece is a synchrotron light source originating from BESSY I, a gift by Germany. The upgraded machine, a 2.5 GeV 3rd Generation Light Source (133m circumference, 26nm-rad emittance and 12 places for insertion devices), will provide light from infra-red to hard X-rays, offering excellent opportunities to train local scientists and attract those working abroad to return. The SESAME Council meets twice each year and presently has nine Members (Bahrain, Cyprus, Egypt, Iran, Israel, Jordan, Pakistan, Palestinian Authority, Turkey). Members have responsibility for the project and provide the annual operations budget (1.5M US dollars in 2009, expected to rise to about 5M when operation starts in 2012-13). Jordan provided the site, building, and infrastructure. A staff of 20 is installing the 0.8 GeV BESSY I injection system. The facility will have the capacity to serve 30 or more experiments operating simultaneously. See www.sesame.org.jo )

  16. Medicinal plants profile used by the 3rd District population of Maceió-AL.

    Science.gov (United States)

    Griz, S A S; Matos-Rocha, T J; Santos, A F; Costa, J G; Mousinho, K C

    2017-05-04

    Herein the use of medicinal plants by the population of the 3rd Sanitary District of Maceió-AL city is reported. Transversal description was conducted from February 2013 to January 2014, with a sample of 116 individuals of both Gender Genders aged over 18 years. The ethnobotanical information interviews ethnobotanical information were obtained through semi - structured questionnaire featuring the use of medicinal plants and social and economical data. Descriptive statistics was applied for quantitative variables as mean and standard deviation and proportions for qualitative variables in the frequency table format. The results showed that 85.34% of the interviewees used plants for medicinal purposes. As the majority of these were (73.28%) females in the age group between 30-60 years of old. Among a total of 45 identified plant species, the highest use frequency were for Boldus Peumus (bilberry), Melissa officinalis (lemon balm), and Mentha piperita (mint). The most widely used plant foliage part was (53.53%) prepared as an infusion (55.5%). The use of medicinal plants in Maceió cityis widespread, highlighting the importance of ethnobotanical knowledge for the study of medicinal plants.

  17. Regional apparent diffusion coefficient values in 3rd trimester fetal brain

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, Chen [Tel Aviv University, Department of Radiology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Sheba Medical Center, Diagnostic Imaging, 52621, Tel Hashomer (Israel); Weisz, Boaz; Lipitz, Shlomo; Katorza, Eldad [Tel Aviv University, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Yaniv, Gal; Bergman, Dafi [Tel Aviv University, Department of Radiology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Biegon, Anat [Stony Brook University School of Medicine, Department of Neurology, Stony Brook, NY (United States)

    2014-07-15

    Apparent diffusion coefficient (ADC) values in the developing fetus can be used in the diagnosis and prognosis of prenatal brain pathologies. To this end, we measured regional ADC in a relatively large cohort of normal fetal brains in utero. Diffusion-weighted imaging (DWI) was performed in 48 non-sedated 3rd trimester fetuses with normal structural MR imaging results. ADC was measured in white matter (frontal, parietal, temporal, and occipital lobes), basal ganglia, thalamus, pons, and cerebellum. Regional ADC values were compared by one-way ANOVA with gestational age as covariate. Regression analysis was used to examine gestational age-related changes in regional ADC. Four other cases of CMV infection were also examined. Median gestational age was 32 weeks (range, 26-33 weeks). There was a highly significant effect of region on ADC, whereby ADC values were highest in white matter, with significantly lower values in basal ganglia and cerebellum and the lowest values in thalamus and pons. ADC did not significantly change with gestational age in any of the regions tested. In the four cases with fetal CMV infection, ADC value was associated with a global decrease. ADC values in normal fetal brain are relatively stable during the third trimester, show consistent regional variation, and can make an important contribution to the early diagnosis and possibly prognosis of fetal brain pathologies. (orig.)

  18. Visual, Critical, and Scientific Thinking Dispositions in a 3rd Grade Science Classroom

    Science.gov (United States)

    Foss, Stacy

    Many American students leave school without the required 21st century critical thinking skills. This qualitative case study, based on the theoretical concepts of Facione, Arheim, and Vygotsky, explored the development of thinking dispositions through the arts in science on the development of scientific thinking skills when used as a conceptual thinking routine in a rural 3rd grade classroom. Research questions examined the disposition to think critically through the arts in science and focused on the perceptions and experiences of 25 students with the Visual Thinking Strategy (VTS) process. Data were collected from classroom observations (n = 10), student interviews (n = 25), teacher interviews ( n = 1), a focus group discussion (n = 3), and artifacts of student work (n = 25); these data included perceptions of VTS, school culture, and classroom characteristics. An inductive analysis of qualitative data resulted in several emergent themes regarding disposition development and students generating questions while increasing affective motivation. The most prevalent dispositions were open-mindedness, the truth-seeking disposition, the analytical disposition, and the systematicity disposition. The findings about the teachers indicated that VTS questions in science supported "gradual release of responsibility", the internalization of process skills and vocabulary, and argumentation. This case study offers descriptive research that links visual arts inquiry and the development of critical thinking dispositions in science at the elementary level. A science curriculum could be developed, that emphasizes the development of thinking dispositions through the arts in science, which in turn, could impact the professional development of teachers and learning outcomes for students.

  19. Book Review: Guide to computer forensics and investigations (3rd ed.

    Directory of Open Access Journals (Sweden)

    Keyu Jiang

    2008-09-01

    Full Text Available Nelson, B., Phillips, A., Enfinger, F., & Steuart, C. (2008. Guide to computer forensics and investigations (3rd ed.. New Jersey: Pearson Education, Inc. 693 pages, ISBN: 1-4180-6733-4 (paper.Reviewed by Keyu Jiang (kjiang@fhsu.edu and Ruifeng Xuan (r_xuan@scatcat.fhsu.edu, Department of Information Networking and Telecommunications, Fort Hays State University, Hays, KS 67601Nelson, Phillips, Enfinger, and Steuart’s book is about the science of computer forensics and its implications in crime investigations. This book is not intended to provide comprehensive training in computer forensics, but introduce the science the science of computer forensics and its implications in crime investigations.  It focused on establishing a solid foundation for those who are new to this field.  Nelson, Philips, Enfiger, and Steuart are experienced experts in different areas of computer forensics.  Different expertise makes this book could benefit many groups of people at different educational level and industrial background.(see PDF for full review

  20. A 3rd Order WENO GLM-MHD Scheme for Magnetic Reconnection

    Institute of Scientific and Technical Information of China (English)

    FENG Xueshang; ZHOU Yufen; HU Yanqi

    2006-01-01

    A new numerical scheme of 3rd order Weighted Essentially Non-Oscillatory (WENO)type for 2.5D mixed GLM-MHD in Cartesian coordinates is proposed. The MHD equations are modified by combining the arguments as by Dellar and Dedner et al to couple the divergence constraint with the evolution equations using a Generalized Lagrange Multiplier (GLM). Moreover, the magnetohydrodynamic part of the GLM-MHD system is still in conservation form. Meanwhile, this method is very easy to add to an existing code since the underlying MHD solver does not have to be modified. To show the validation and capacity of its application to MHD problem modelling,interaction between a magnetosonic shock and a denser cloud and magnetic reconnection problems are used to verify this new MHD code. The numerical tests for 2D Orszag and Tang's MHD vortex,interaction between a magnetosonic shock and a denser cloud and magnetic reconnection problems show that the third order WENO MHD solvers are robust and yield reliable results by the new mixed GLM or the mixed EGLM correction here even if it can not be shown that how the divergence errors are transported as well as damped as done for one dimensional ideal MHD by Dedner et al.

  1. Measurement and correction of the 3rd order resonance in the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F.; /CERN; Alexahin, Y.; Lebedev, V.; Still, D.; Valishev, A.; /Fermilab

    2006-06-01

    At Fermilab Tevatron BPM system has been recently upgraded resulting much better accuracy of beam position measurements and improvements of data acquisition for turn-by-turn measurements. That allows one to record the beam position at each turn for 8000 turns for all BPMs (118 in each plane) with accuracy of about 10-20 {micro}m. In the last decade a harmonic analysis tool has been developed at CERN that allows relating each FFT line derived from the BPM data with a particular non-linear resonance in the machine. In fact, one can even detect the longitudinal position of the sources of these resonances. Experiments have been performed at the Tevatron in which beams have been kicked to various amplitudes to analyze the 3rd order resonance. It was possible to address this rather large resonance to some regular machine sextupoles. An alternative sextupole scheme allowed the suppression of this resonance by a good factor of 2. Lastly, the experimental data are compared with model calculations.

  2. Visual Arts Teaching in Kindergarten through 3rd-Grade Classrooms in the UAE: Teacher Profiles, Perceptions, and Practices

    Science.gov (United States)

    Buldu, Mehmet; Shaban, Mohamed S.

    2010-01-01

    This study portrayed a picture of kindergarten through 3rd-grade teachers who teach visual arts, their perceptions of the value of visual arts, their visual arts teaching practices, visual arts experiences provided to young learners in school, and major factors and/or influences that affect their teaching of visual arts. The sample for this study…

  3. Peter Landin: a computer scientist who inspired a generation, 5th June 1930 - 3rd June 2009

    OpenAIRE

    2009-01-01

    Peter Landin: a computer scientist who inspired a generation, 5th June 1930 - 3rd June 2009 (Bornat, Richard) School of Engineering and Information Sciences, Middlesex University - The Burroughs, NW4 4BT - London - UNITED KINGDOM (Bornat, Richard) UNITED KINGDOM Registration: 2009-07-24 ePublished: 2009-08-13

  4. The Lived Experiences of 3rd Generation and beyond U.S.-Born Mexican Heritage College Students: A Qualitative Study

    Science.gov (United States)

    Galvan, Richard

    2011-01-01

    The purpose of this study was to describe the psychosocial and identity challenges of 3rd generation and beyond U.S.-born (3GAB-USB) Mexican heritage college students. Alvarez (1973) has written about the psychosocial impact "hybridity" can have on a U.S.- born (USB) Mexican individual who incorporates two distinct cultures (American and Mexican)…

  5. Internationalisation at Home in a Global Perspective: A critical Survey of the 3rd Global Survey Report of IAU

    NARCIS (Netherlands)

    Beelen, J.

    2011-01-01

    This article takes the 3rd Global Survey Report of the International Association of Universities (IAU) as a starting point. The results of this worldwide survey were published in September 2010. The article discusses four questions from the survey that include internationalisation at Home (IaH) and

  6. Constancy and Variability: Dialogic Literacy Events as Sites for Improvisation in Two 3rd-Grade Classrooms

    Science.gov (United States)

    Jordan, Michelle E.; Santori, Diane

    2015-01-01

    This multisite study investigates dialogic literacy events that revolved around narrative and informational texts in two 3rd-grade classrooms. The authors offer a metaphor of musical improvisation to contemplate dialogic literacy events as part of the repertoire of teaching and learning experiences. In literacy learning, where there is much…

  7. Knowledge and institutional requirements to promote land degradation neutrality in drylands - An analysis of the outcomes of the 3rd UNCCD scientific conference

    Science.gov (United States)

    Akhtar-Schuster, Mariam; Safriel, Uriel; Abraham, Elena; de Vente, Joris; Essahli, Wafa; Escadafal, Richard; Stringer, Lindsay

    2015-04-01

    Achieving land degradation neutrality (LDN) through sustainable land management (SLM) targets the maintenance or restoration of the productivity of land, and therefore has to include decision-makers, knowledge generators and knowledge holders at the different relevant geographic scales. In order to enhance the implementation of the Convention, the Conference of the Parties (COP) of the United Nations Convention to Combat Desertification therefore decided that each future session of its Committee on Science and Technology (CST) would be organized in a predominantly scientific and technical conference-style format. This contribution will outline the major outcomes of UNCCD's 3rd scientific conference that will be held in Cancún, Mexico, from 9 to 12 March 2015, on addressing desertification, land degradation and drought issues (DLDD) for poverty reduction and sustainable development. The conference follows an exceptional new round table conference format that will allow the various stakeholders to discuss scientific as well as the contribution of traditional knowledge and practices in combating land degradation. This format should provide two-way communication and enable deeper insight into the availability and contribution of all forms of knowledge for achieving LDN through the assessment of: • the vulnerability of lands to DLDD and climate change and the adaptive capacities of socio-ecosystems; • best examples of adapted, knowledge-based practices and technologies; • monitoring and assessment methods to evaluate the effectiveness of adaptation practices and technologies. The outcomes of UNCCD's 3rd scientific conference will serve as a basis for discussing: • contributions of science to diagnose the status of land; • research gaps that need to be addressed to achieve LDN for poverty reduction; • additional institutional requirements to optimally bridge knowledge generation, knowledge maintenance and knowledge implementation at the science

  8. Nuclease-mediated genome editing: At the front-line of functional genomics technology.

    Science.gov (United States)

    Sakuma, Tetsushi; Woltjen, Knut

    2014-01-01

    Genome editing with engineered endonucleases is rapidly becoming a staple method in developmental biology studies. Engineered nucleases permit random or designed genomic modification at precise loci through the stimulation of endogenous double-strand break repair. Homology-directed repair following targeted DNA damage is mediated by co-introduction of a custom repair template, allowing the derivation of knock-out and knock-in alleles in animal models previously refractory to classic gene targeting procedures. Currently there are three main types of customizable site-specific nucleases delineated by the source mechanism of DNA binding that guides nuclease activity to a genomic target: zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR). Among these genome engineering tools, characteristics such as the ease of design and construction, mechanism of inducing DNA damage, and DNA sequence specificity all differ, making their application complementary. By understanding the advantages and disadvantages of each method, one may make the best choice for their particular purpose.

  9. Catalysis in the 3rd Dimension: How Organic Molecules May be Formed

    Science.gov (United States)

    Freund, Friedemann; DeVincenzi, D. (Technical Monitor)

    2001-01-01

    Catalysis is often little more than a word to phenomenologically describe the fact that a reaction follows a pat1 that leads to products of an unexpected kind or of unexpected yield. Low activation energy barriers for intermediates are recognized as the most likely cause why a system deviates from the thermodynamic pull towards minimizing its free energy and ends up in a metastable state. Seldom is the mechanism known. This i: particularly true for heterogeneous catalysis under hydrothermal conditions with minerals as catalysts. It is commonly assumed that catalytic action takes place across solid-fluid interfaces and that, on the atomic level, interfaces are just 2-dimensional contacts. This makes it difficult to understand, for instance, the assembly of long-chain carboxylic (fatty) acids. 3y studying single crystals that grew from a melt in the presence of H2O and CO2, we can show: (1) that numerals take up the fluid components into solid solution, (2) that some-thing happens converting them to -educedH and C, (3) that C atoms segregate into dislocations and tie C-C bonds. The products are medium-to-long chain Cn protomolecules, with some C-H attached, pre-assembled in the dislocations. Upon solvent extraction, these proto-molecules turn into carboxylic and dicarboxylic acids. This observation suggests that, in a very elementary step, catalysis under hydrothermal conditions leading to fatty acids involves the pre-assembly of Cn entities in the interface that is not 2-D but extends into the 3rd dimension, with dislocations as synthesis sites.

  10. Federal Technology Alert: Ground-Source Heat Pumps Applied to Federal Facilities--Second Edition

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Donald L.

    2001-03-01

    This Federal Technology Alert, which was sponsored by the U.S. Department of Energy's Office of Federal Energy Management Programs, provides the detailed information and procedures that a Federal energy manager needs to evaluate most ground-source heat pump applications. This report updates an earlier report on ground-source heat pumps that was published in September 1995. In the current report, general benefits of this technology to the Federal sector are described, as are ground-source heat pump operation, system types, design variations, energy savings, and other benefits. In addition, information on current manufacturers, technology users, and references for further reading are provided.

  11. PREFACE: 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015)

    Science.gov (United States)

    Gaol, F. L.

    2015-06-01

    The 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015), was held at The Westin Resort Nusa Dua, Bali on 31 January - 1 February 2015. The ScieTech 2015 conference is aimed to bring together researchers, engineers and scientists from around the world. ScieTech 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within mathematics, chemistry and physics. As we already know that science and technology have brought tremendous benefits for human civilization. People are becoming healthier, wealthier, better educated, more peaceful, increasingly connected, and living longer. Of course, science and technology provide many answers to global challenges, but we will face more complex problems in the next decade due to increasing world population, limitation of energy, and climate change. Therefore, researchers should be more active in conducting research that enables collaboration between one and the others. Interdisciplinary cooperation is absolutely necessary in order to create a smart system for solving the global problems. We need a global and general long-term view of the future with long-range goals for solving complex problems in next decade. Therefore the conference was held to be a forum for researchers from different disciplines to start collaborating and conducting research that provides a solution to the global issues. The theme of ScieTech 2015 was ''The interdisciplinary Application between Mathematics, Chemistry and Physics to enhance the Quality of Life''. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting conference program as well as the invited and plenary speakers. This year, we received 197 papers and after rigorous review, 59 papers were accepted. The participants came from 19

  12. Montpellier Infectious Diseases - Pôle Rabelais (MID) 3rd annual meeting (2014).

    Science.gov (United States)

    Besteiro, Sébastien; Blanc-Potard, Anne; Bonazzi, Matteo; Briant, Laurence; Chazal, Nathalie; Cornillot, Emmanuel; Lentini, Gaëlle; Matkovic, Roy; Sanosyan, Armen; Tuaillon, Edouard; Van de Perre, Philippe

    2015-06-01

    For the third time, teams belonging to the "Montpellier Infectious Diseases" network in the Rabelais BioHealth Cluster held their annual meeting on the 27th and 28th of November in Montpellier, France. While the 2012 meeting was focused on the cooperation between the local force tasks in biomedical and medical chemistry and presented the interdisciplinary research programs designed to fight against virus, bacteria and parasites, the 2014 edition of the meeting was focused on the translational research in infectious diseases and highlighted the bench-to-clinic strategies designed by academic and private research groups in the Montpellier area.

  13. Renewable Energies and CO2 Cost Analysis, Environmental Impacts and Technological Trends- 2012 Edition

    CERN Document Server

    Guerrero-Lemus, Ricardo

    2013-01-01

    Providing up-to-date numerical data across a range of topics related to renewable energy technologies, Renewable Energies and CO2 offers a one-stop source of key information to engineers, economists and all other professionals working in the energy and climate change sectors. The most relevant up-to-date numerical data are exposed in 201 tables and graphs, integrated in terms of units and methodology, and covering topics such as energy system capacities and lifetimes, production costs, energy payback ratios, carbon emissions, external costs, patents and literature statistics. The data are first presented and then analyzed to project potential future grid, heat and fuel parity scenarios, as well as future technology tendencies in different energy technological areas. Innovative highlights and descriptions of preproduction energy systems and components from the past four years have been gathered from selected journals and international energy departments from G20 countries. As the field develops, readers are in...

  14. EDITORIAL: Photonica 2011: 3rd International School and Conference on Photonics Photonica 2011: 3rd International School and Conference on Photonics

    Science.gov (United States)

    Petrović, Jovana; Stepić, Milutin; Hadžievski, Ljupčo

    2012-04-01

    Photonics is a rapidly growing discipline of physics that investigates properties of light and its interaction with matter and develops devices based on these properties. Due to both the fundamental and applied nature of photonics research, it pervades many branches of modern technology: quantum mechanics, material science, electronics, telecommunications, biology, medicine, material processing, etc. The borders between these subjects are being erased, generating new research areas such as silicon photonics, biophotonics and quantum photonics. Diverse branches of photonics are united in a common effort to further miniaturize photonic devices, integrate them with existing technologies and develop new technologies. The International School and Conference on Photonics—Photonica—is a biennial forum for the education of young scientists, exchanging new knowledge and ideas, and fostering collaboration between scientists working in photonic science and technology. Conference topics cover a broad range of research activities in optical materials, metamaterials and plasmonics, nonlinear optics, lasers, laser spectroscopy, biophotonics, optoelectronics, optocommunications, photonic crystals, holography, quantum optics and related topics in atomic physics. The aim of the organizers is to provide a platform for discussing new developments, concepts and future trends of various disciplines of photonics by bringing together researchers from academia, government and industrial laboratories. The educational element of Photonica—a series of tutorials and keynote talks—enables students and young researchers to better understand the fundamentals and their use on a route to applications, and informs both young and experienced scientists of new directions of research. The introductory lectures that are directly related to the state-of-the-art are followed by presentations and discussions on recent results during oral and vibrant poster presentations. This Topical Issue is

  15. Asymmetrical Challenges: Technology in an Era of Persistent Conflict (Army Space Journal, 2009 Spring Edition)

    Science.gov (United States)

    2009-01-01

    very competitive world over the next forty years. Just in technology, an iPod by 2020 will be able to hold the entire Library of Congress. A home...can pass that to all the disadvantaged users and not be reliant on one path. In friendly force tracking, again we have to develop a num- ber of

  16. PREFACE: 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS 2012)

    Science.gov (United States)

    Tayurskii, Dmitrii; Abe, Sumiyoshi; Alexandre Wang, Q.

    2012-11-01

    The 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS2012) was held between 25-30 August at Kazan (Volga Region) Federal University, Kazan, Russian Federation. This workshop was jointly organized by Kazan Federal University and Institut Supérieur des Matériaux et Mécaniques Avancées (ISMANS), France. The series of SPMCS workshops was created in 2008 with the aim to be an interdisciplinary incubator for the worldwide exchange of innovative ideas and information about the latest results. The first workshop was held at ISMANS, Le Mans (France) in 2008, and the third at Huazhong Normal University, Wuhan (China) in 2010. At SPMCS2012, we wished to bring together a broad community of researchers from the different branches of the rapidly developing complexity science to discuss the fundamental theoretical challenges (geometry/topology, number theory, statistical physics, dynamical systems, etc) as well as experimental and applied aspects of many practical problems (condensed matter, disordered systems, financial markets, chemistry, biology, geoscience, etc). The program of SPMCS2012 was prepared based on three categories: (i) physical and mathematical studies (quantum mechanics, generalized nonequilibrium thermodynamics, nonlinear dynamics, condensed matter physics, nanoscience); (ii) natural complex systems (physical, geophysical, chemical and biological); (iii) social, economical, political agent systems and man-made complex systems. The conference attracted 64 participants from 10 countries. There were 10 invited lectures, 12 invited talks and 28 regular oral talks in the morning and afternoon sessions. The book of Abstracts is available from the conference website (http://www.ksu.ru/conf/spmcs2012/?id=3). A round table was also held, the topic of which was 'Recent and Anticipated Future Progress in Science of Complexity', discussing a variety of questions and opinions important for the understanding of the concept of

  17. Building monument materials during the 3rd-4rd millennium (Portugal)

    Science.gov (United States)

    Moita, Patricia; Pedro, Jorge; Boaventura, Rui; Mataloto, Rui; Maximo, Jaime; Almeida, Luís; Nogueira, Pedro

    2014-05-01

    Dolmens are the most conspicuous remains of the populations of the 4th and first half of 3rd millennia BCE. These tombs are impressive not only for their monumentality, but also because of the socioeconomic investment they represent for those Neolithic communities, namely from the Central-South of Portugal, who built them. Although dolmens have been studied for their funerary content and typologies, an interdisciplinary approach toward the geological characterization and sourcing of stones used in these constructions has not received enough attention from researchers. With MEGAGEO project a multidisciplinary group of geologist and archaeologists intends to assess the relationship between the distribution of dolmens in Central-South Portugal, their source materials, and the geological landscape. GIS will map the information gathered and will be used to analyse these relationships. The selection of the areas, with distinctive geologies (limestone vs granite), will allow to verify if human patterns of behaviour regarding the selection of megaliths are similar or different regionally. Geologically the first target area (Freixo, Alentejo) is dominated by a small intrusion of gabbro mingled/mixed within a granodioritic intrusion both related with variscan orogeny. Granodiorite exhibit several enclaves of igneous and metamorphic nature attesting the interaction between both igneous rocks as well with enclosing gneisses. Despite Alentejo region have a reduced number of outcrops the granodiorite provides rounded to tabular metric blocks. The gabbro is very coarse grained, sometimes with a cumulate texture, and their fracturing and weathering provide very fresh tabular blocks. The five studied dolmens (Quinta do Freixo #1 to #5) are implanted in a large granodioritic intrusion, around the gabbroic rocks, within an area of approximately 9km2. The medium grained granodiorite is ubiquity in all the dolmens slabs and occasionally it can be observed features of mixing and

  18. Coronal MR imaging of the normal 3rd, 4th, and 5th lumbar and 1st sacral nerve roots

    Energy Technology Data Exchange (ETDEWEB)

    Hald, J.K.; Nakstad, P.H.; Hauglum, B.E. (National Hospital, Oslo (Norway). Dept. of Radiology)

    1991-05-01

    Seven healthy volunteers underwent coronal MR imaging at 1.5 tesla of the normal 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots. Coronal slices, 3-mm-thick with a 0.3-mm gap between the slices were obtained (TR/TE 600/22) through the lumbar spinal canal. All the nerve roots were visible on at least one image. One can routinely expect to demonstrate the 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots on T1-weighted, 3-mm-thick coronal MR scans. We found no correlation between the degree of lumbar lordosis and the lengths of the visible nerve roots. Five patients with one of the following spinal problems: anomaly, tumor, disk herniation, and failed back surgery syndrome were examined according to our protocol. In all these cases coronal MR imaging gave the correct diagnosis. (orig.).

  19. Mechanical design and engineering of the 3.9 GHZ, 3rd harmonic SRF system at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Don Mitchell et al.

    2004-08-05

    The mechanical development of the 3.9 GHz, 3rd Harmonic SRF System is summarized to include: the development of a full scale copper prototype cavity structure; the design of the niobium 3 cell and niobium 9 cell structures; the design of the helium vessel and cryostat; the HOM coupler design; and a preliminary look at the main coupler design. The manufacturing processes for forming, rolling, and e-beam welding the HOM coupler, cavity cells, and end tubes are also described. Due to the exotic materials and manufacturing processes used in this type of device, a cost estimate for the material and fabrication is provided. The 3rd harmonic design is organized via a web-based data management approach.

  20. Plant chromatin warms up in Madrid: meeting summary of the 3rd European Workshop on Plant Chromatin 2013, Madrid, Spain.

    Science.gov (United States)

    Jarillo, José A; Gaudin, Valérie; Hennig, Lars; Köhler, Claudia; Piñeiro, Manuel

    2014-04-01

    The 3rd European Workshop on Plant Chromatin (EWPC) was held on August 2013 in Madrid, Spain. A number of different topics on plant chromatin were presented during the meeting, including new factors mediating Polycomb Group protein function in plants, chromatin-mediated reprogramming in plant developmental transitions, the role of histone variants, and newly identified chromatin remodeling factors. The function of interactions between chromatin and transcription factors in the modulation of gene expression, the role of chromatin dynamics in the control of nuclear processes and the influence of environmental factors on chromatin organization were also reported. In this report, we highlight some of the new insights emerging in this growing area of research, presented at the 3rd EWPC.

  1. A 3rd Order Low Power SI Sigma-Delta A/D Converter for Voice-Band Applications

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Herald Holger; Bogason, Gudmundur

    1997-01-01

    This paper presents a 3rd order switched current-ΣΔ-modulator. The ΣΔ-modulator operates at a sampling rate of fs=600 kHz and the signal band is fb=5.5 kHz, i.e., an oversampling factor of R=54.5 is used. Multiple input signals are used to reduce the internal signal swings which results in reduced...

  2. Tunneling of the 3rd Kind: A Test of the Effective Non-locality of Quantum Field Theory

    OpenAIRE

    Gardiner, S. A.; Gies, H.; Jaeckel, J.; Wallace, C. J.

    2012-01-01

    Integrating out virtual quantum fluctuations in an originally local quantum field theory results in an effective theory which is non-local. In this Letter we argue that tunneling of the 3rd kind - where particles traverse a barrier by splitting into a pair of virtual particles which recombine only after a finite distance - provides a direct test of this non-locality. We sketch a quantum-optical setup to test this effect, and investigate observable effects in a simple toy model.

  3. EXPOSE-R2, the 3rd successful EXPOSE mission – a mission and mission ground reference overview

    OpenAIRE

    2016-01-01

    For nearly 2 years the 3rd ESA EXPOSE mission, the 2nd on the Russian Zvezda module of the ISS, exposed a variety of astrobiological samples to space and simulated Mars environmental conditions. Various chemical compounds and organisms like bacteria, archaea, fungi, plant seeds, lychens, mosses and animal eggs and larvae from the international experiments BIOMEX, BOSS, P.S.S. and the IBMP-experiment were exposed to space vacuums dryness, extraterrestrial short wavelength UV, radiation and tem...

  4. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    OpenAIRE

    Goh, Khoon Song Aloysius; Wee, Loo Kang; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted ...

  5. Additional circular intercostal space created by bifurcation of the left 3rd rib and its costal cartilage: a case report

    Directory of Open Access Journals (Sweden)

    Kumar Naveen

    2013-01-01

    Full Text Available Abstract Introduction In the thorax there are normally 11 pairs of intercostal spaces: the spaces between adjacent ribs. The intercostal spaces contain intercostal muscles, intercostal nerves and vessels. Case presentation During a routine dissection for undergraduate medical students, we observed a variation involving the left 3rd rib and 3rd costal cartilage in the cadaver of a man of Indian ethnicity aged about 65 years. The left 3rd rib and its costal cartilage were bifurcated at their costochondral junction enclosing a small circular additional intercostal space. Muscle tissue covered by deep fascia was present in this circular intercostal space. The muscle in the circular intercostal space received its nerve supply from a branch of the 2nd intercostal nerve. Conclusions Knowledge of such variations is helpful to surgeons operating on the anterior thoracic wall involving ribs and intercostal spaces. Knowing the possibility of the presence of an additional space between normal intercostal spaces can guide a surgeon through to a successful surgery.

  6. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    CERN Document Server

    Goh, Khoon Song Aloysius; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted by three teachers in the school. Results suggest, at 95 percent confidence level, significant improvement for concept of Newtons 1st Law while not so for Newtons 3rd Law. A Focus Group Discussion revealed students confirming the usefulness of the EJS model in visualizing the 1st Law while not so much for the 3rd Law. We speculate the design ideas for constant velocity motion in the computer model coupled with the PbI worksheet did allow for making sense and experiencing of the 1st Law, where traditional pen-paper represen...

  7. 3rd International Conference on Condition Monitoring of Machinery in Non-Stationary Operations

    CERN Document Server

    Rubini, Riccardo; D'Elia, Gianluca; Cocconcelli, Marco; Chaari, Fakher; Zimroz, Radoslaw; Bartelmus, Walter; Haddar, Mohamed

    2014-01-01

    This book presents the processings of the third edition of the Condition Monitoring of Machinery in Non-Stationary Operations (CMMNO13) which was held in Ferrara, Italy. This yearly event merges an international community of researchers who met – in 2011 in Wroclaw (Poland) and in 2012 in Hammamet (Tunisia) – to discuss issues of diagnostics of rotating machines operating in complex motion and/or load conditions. The growing interest of the industrial world on the topics covered by the CMMNO13 involves the fields of packaging, automotive, agricultural, mining, processing and wind machines in addition to that of the systems for data acquisition.The participation of speakers and visitors from industry makes the event an opportunity for immediate assessment of the potential applications of advanced methodologies for the signal analysis. Signals acquired from machines often contain contributions from several different components as well as noise. Therefore, the major challenge of condition monitoring is to po...

  8. 3rd International Workshop on Advances in Simulation-Driven Optimization and Modeling

    CERN Document Server

    Leifsson, Leifur; Yang, Xin-She

    2016-01-01

    This edited volume is devoted to the now-ubiquitous use of computational models across most disciplines of engineering and science, led by a trio of world-renowned researchers in the field. Focused on recent advances of modeling and optimization techniques aimed at handling computationally-expensive engineering problems involving simulation models, this book will be an invaluable resource for specialists (engineers, researchers, graduate students) working in areas as diverse as electrical engineering, mechanical and structural engineering, civil engineering, industrial engineering, hydrodynamics, aerospace engineering, microwave and antenna engineering, ocean science and climate modeling, and the automotive industry, where design processes are heavily based on CPU-heavy computer simulations. Various techniques, such as knowledge-based optimization, adjoint sensitivity techniques, and fast replacement models (to name just a few) are explored in-depth along with an array of the latest techniques to optimize the...

  9. Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology

    Science.gov (United States)

    Kang, Jung-Taek; Kwon, Dae-Kee; Park, A-Rum; Lee, Eun-Jin; Yun, Yun-Jin; Ji, Dal-Young; Lee, Kiho

    2016-01-01

    Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease (TALEN) system in generating specific mutations on the pig genome. Specific TALEN was designed to induce a double-strand break on exon 9 of the porcine α1,3-galactosyltransferase (GGTA1) gene as it is the main cause of hyperacute rejection after xenotransplantation. Human decay-accelerating factor (hDAF) gene, which can produce a complement inhibitor to protect cells from complement attack after xenotransplantation, was also integrated into the genome simultaneously. Plasmids coding for the TALEN pair and hDAF gene were transfected into porcine cells by electroporation to disrupt the porcine GGTA1 gene and express hDAF. The transfected cells were then sorted using a biotin-labeled IB4 lectin attached to magnetic beads to obtain GGTA1 deficient cells. As a result, we established GGTA1 knockout (KO) cell lines with biallelic modification (35.0%) and GGTA1 KO cell lines expressing hDAF (13.0%). When these cells were used for somatic cell nuclear transfer, we successfully obtained live GGTA1 KO pigs expressing hDAF. Our results demonstrate that TALEN-mediated genome editing is efficient and can be successfully used to generate gene edited pigs. PMID:27051344

  10. Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology.

    Science.gov (United States)

    Kang, Jung-Taek; Kwon, Dae-Kee; Park, A-Rum; Lee, Eun-Jin; Yun, Yun-Jin; Ji, Dal-Young; Lee, Kiho; Park, Kwang-Wook

    2016-03-01

    Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease (TALEN) system in generating specific mutations on the pig genome. Specific TALEN was designed to induce a double-strand break on exon 9 of the porcine α1,3-galactosyltransferase (GGTA1) gene as it is the main cause of hyperacute rejection after xenotransplantation. Human decay-accelerating factor (hDAF) gene, which can produce a complement inhibitor to protect cells from complement attack after xenotransplantation, was also integrated into the genome simultaneously. Plasmids coding for the TALEN pair and hDAF gene were transfected into porcine cells by electroporation to disrupt the porcine GGTA1 gene and express hDAF. The transfected cells were then sorted using a biotin-labeled IB4 lectin attached to magnetic beads to obtain GGTA1 deficient cells. As a result, we established GGTA1 knockout (KO) cell lines with biallelic modification (35.0%) and GGTA1 KO cell lines expressing hDAF (13.0%). When these cells were used for somatic cell nuclear transfer, we successfully obtained live GGTA1 KO pigs expressing hDAF. Our results demonstrate that TALEN-mediated genome editing is efficient and can be successfully used to generate gene edited pigs.

  11. CELEBRATION OF DECEMBER 3RD, INTERNATIONAL DAY OF PERSONS WITH DISABILITIES

    Directory of Open Access Journals (Sweden)

    Maja FILIPOVSKA

    2017-03-01

    Full Text Available On December 2nd 2016 in the main amphitheater at the Faculty of Philosophy in Skopje, was held the celebration of December 3rd, the International Day of Persons with Disabilities, in organization of the Institute of Special Education and Rehabilitation. The official part of the program was started with a speech by Goran Ajdinski, PhD, the Dean of the Faculty of Philosophy in Skopje. The guests at the celebration were also greeted by the Rector of the University “Ss. Cyril and Methodius” – Skopje, Nikola Jankulovski, PhD and the Minister of Labor and Social Policy of Republic of Macedonia, Frosina Tashevska-Remenski, PhD. After the speeches, which highlighted the current efforts and future commitment to inclusion and accessibility of persons with disabilities, two awards were presented by the Humanitarian foundation “Prof. d-r Ljupco Ajdinski”. The first award was given to Simona Kostadinova as the student with achieved highest grade point average of 9.65 in the generation 2011/12 during the studies of Special education and rehabilitation. The second award was intended for the highest ranked student at the university admission in 2016/2017. This award belonged to Nadica Gjerasimova who had 97.70 points on the official rank list. Beside the awards, two acknowledgements for humanity were also given by the Foundation “Prof. d-r Ljupco Ajdinski”. For the longstanding human activity in preparation of special education and rehabilitation staff and education and rehabilitation of persons with disabilities, the first acknowledgement was given to the Institute of Special education and rehabilitation. The second acknowledgement was meant for Kiril Temkov, PhD, about his numerous initiated and organized human activities, especially for the published paper on the ethical dimensions of special education and rehabilitation and introduction of Ethics in the education system in Republic of Macedonia. The last part of the program was intended for

  12. Preoperative and Postoperative (1st and 3rd Month Metabolic Data of Patients Who Underwent Bariatric Surgery

    Directory of Open Access Journals (Sweden)

    Nilüfer Özdemir Kutbay

    2015-03-01

    Full Text Available Purpose: The growing prevalence of obesity has become a major concern. The efficacy of medical treatment, diet and behavior therapy in morbidly obese patients is limited. Obesity surgery is a treatment option for selected morbidly obese patients. Material and Method: Data of 47 patients (n=39 women, 8 men who underwent bariatric surgery were investigated. Results: Out of 47 patients, 20 underwent Roux-en-Y gastric bypass (RYGB (43% and 27 had sleeve gastrectomy (SG (57%. The mean age of the patients was 37±9.5 (19-59 years. 17% of patients were men and 83% were women. In the analysis of data on weight that could be found for 31 out of 47 patients, we detected preoperative and postoperative (1st and 3rd month mean weight values as 125.4±15.9 kg, 112.7±13.2 kg (p<0.001 and 100.9±17.5 kg (p<0.001, respectively. In addition, the analysis of the data on mean fasting plasma glucose (FPG levels which could be found for 23 out of 47 patients, showed us that preoperative and postoperative (1st and 3rd month FPG levels were 100.9±17.5 mg/dL, 91.6±10.9 mg/dL (p=0.03 and 87.3±2.0 mg/dL, respectively. Only 1 patient had diabetes before the surgery. In the RYGB group, the mean change in weight was 12.4±5.5 kg in the 1st month and 22.2±8.6 kg in the 3rd month (compared to the weights in the preoperative period. Moreover, in the SG group, the mean change in weight was 13.7±4.5 kg in the 1st month and 23.4±5.8 kg in the 3rd month. No statistically significant difference was found between the weight changes in the 1st and the 3rd month as for surgery types. Discussion: After bariatric surgery, significant loss in weight and reduction in FPG occurred in short-term.

  13. The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models.

    Science.gov (United States)

    Shao, Ming; Xu, Tian-Rui; Chen, Ce-Shi

    2016-07-18

    Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for studying gene function through efficient knock-out, knock-in or chromatin modification of the targeted gene loci in various cell types and organisms. It can be applied in a number of fields, such as genetic breeding, disease treatment and gene functional investigation. In this review, we introduce the most recent developments and applications, the challenges, and future directions of Cas9 in generating disease animal model. Derived from the CRISPR adaptive immune system of bacteria, the development trend of Cas9 will inevitably fuel the vital applications from basic research to biotechnology and bio-medicine.

  14. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  15. Efficient Conversion of Carbon Dioxide into Methane using 3rd Generation Ionic Liquids Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This work directly addresses a technology of interest listed in Section 9, sub-section H1.01 In-Situ Resource Utilization, specifically "Highly efficient reactors...

  16. Stages of Geoinformation Evolution Related to the Territories Described in the Bible - from the 3Rd Millennium B.C. to Modern Times

    Science.gov (United States)

    Linsenbarth, Adam

    2012-09-01

    The paper presents consecutive stages of the evolution of geoinformation related to the territories of the events described in the Bible. Two geoinformation sources are presented: the Bible and non-Bible sources. In the Bible there is much, often some highly detailed information regarding terrain topography. The oldest non-Bible sources are incorporated in the ancient documents, which were discovered in Egypt and Mesopotamia. Some of them are related to the 3rd millen- nium B.C. The further stages are related to the onomasticons and itineraries written by travellers and pilgrims to the Holy Land. The most famous onomasticons include: onomasticons prepared by bishop Eusebius from Caesarea and those pre- pared by St. Jerome. One of the oldest maps of Palestine's territory is the so-called mosaic map of Madaba dated to 565. In the 15th century several Bible maps were edited. The most rapid evolution occurred in the 16th and 17* centuries, when the world famous cartographers such as Mercator and Ortelius edited several maps of Palestine's territory. Cartographers from several European countries edited more than 6,000 maps presenting the Biblical territories and Biblical events. Modem maps, based on detailed topographical surveys, were edited m the second half of the 19* and 20th centuries. W artykule przedstawiono kolejne etapy rozwoju geoinformacji dotyczącej terenówr biblijnych. Omówiono dwa źródła informacji, a mianowicie geoinformacje biblijne i pozabiblijne. W tekstach biblijnych można znaleźć wiele, często bardzo detalicznych informacji topograficznych. Najstarsze źródła pozabiblijne, to starożytne dokumenty odnalezione na terenach Egiptu i Mezopotamii. Niektóre z nich pochodzą z trzeciego milenium przed Chr. Kolejnym etapem geoinformacji były onomastikony oraz dzienniki podróży pisane przez podróżników i pielgrzymów do Ziemi Świętej. Do najbardziej znanych należy onomastikon sporządzony przez biskupa Euzebiusza z Cezarei oraz

  17. Color Portion of Solar Radiation in the Partial Annular Solar Eclipse, October 3rd, 2005, at Helwan, Egypt

    OpenAIRE

    A. H. Hassan; U. A. Rahoma; Sabry, M; A. M. Fathy

    2010-01-01

    Measurements were made of various solar radiation components, global, direct and diffuse and their fractions during the partial annular solar eclipse on October 3rd, 2005 at Helwan, Egypt (Lat. 29.866◦ N and Long. 31.20◦ E), and an analysis has been made. The duration of the solar eclipse was 3 h 17 min, and the maximum magnitude of the eclipse in this region was 0.65. The optical depth of the direct component and the relative humidity decreased, while both the transparency and the air temper...

  18. Summary of the 3rd International Workshop on a Far Detector in Korea for the J-PARC Beam

    CERN Document Server

    Kajita, T; Rubbia, André

    2008-01-01

    The 3rd International Workshop on a Far Detector in Korea for the J-PARC Neutrino Beam was held at the Hongo Campus of Tokyo University, Tokyo, Japan on Sep. 30th and October 1, 2007. Forty seven physicists from Japan and Korea, as well as Europe and USA, participated in the workshop and discussed the physics opportunities offered by the J-PARC conventional neutrino beam detected by a new large underground neutrino detector in Korea. In this paper, we highlight some of the most relevant findings of the workshop.

  19. Influence of solar eclipse of November 3rd, 2013 on the total ozone column over Badajoz, Spain

    OpenAIRE

    Mateos, D.; M. Antón; Vaquero, J. M.

    2014-01-01

    The hybrid eclipse of November 3rd, 2013 was observed as partial with a magnitude equal to 0.126 from Badajoz (38^\\circ 53' N, 6^\\circ 58' W). The evolution of the Total Ozone Column (TOC) values during 4 hours was monitored using a Solar Light Microtops-II manual sun-photometer. Before the eclipse, TOC remained invariable ~280 Dobson Units (DU) for one hour and a half. Once the eclipse was started, a clear decrease in TOC occurred. After the eclipse maximum (with TOC = 273 DU), a rapid TOC r...

  20. Influence of solar eclipse of November 3rd, 2013 on the total ozone column over Badajoz, Spain

    CERN Document Server

    Mateos, D; Vaquero, J M

    2014-01-01

    The hybrid eclipse of November 3rd, 2013 was observed as partial with a magnitude equal to 0.126 from Badajoz (38^\\circ 53' N, 6^\\circ 58' W). The evolution of the Total Ozone Column (TOC) values during 4 hours was monitored using a Solar Light Microtops-II manual sun-photometer. Before the eclipse, TOC remained invariable ~280 Dobson Units (DU) for one hour and a half. Once the eclipse was started, a clear decrease in TOC occurred. After the eclipse maximum (with TOC = 273 DU), a rapid TOC recovery was observed. When the eclipse was over, TOC came back to values ~280 DU.

  1. Tunnelling of the 3rd kind: A test of the effective non-locality of quantum field theory

    Science.gov (United States)

    Gardiner, Simon A.; Gies, Holger; Jaeckel, Joerg; Wallace, Chris J.

    2013-03-01

    Integrating out virtual quantum fluctuations in an originally local quantum field theory results in an effective theory which is non-local. In this letter we argue that tunnelling of the 3rd kind —where particles traverse a barrier by splitting into a pair of virtual particles which recombine only after a finite distance— provides a direct test of this non-locality. We sketch a quantum-optical setup to test this effect, and investigate observable effects in a simple toy model.

  2. A 3rd Generation Advanced High-Strength Steel (AHSS) Produced by Dual Stabilization Heat Treatment (DSHT)

    Science.gov (United States)

    Qu, Hao; Michal, Gary M.; Heuer, Arthur H.

    2013-10-01

    A 3rd generation advanced high-strength steel containing, in wt pct, 0.3 C, 4.0 Mn, 1.5 Al, 2.1 Si, and 0.5 Cr has been produced using a dual stabilization heat treatment—a five stage thermal processing schedule compatible with continuous galvanized steel production. In excess of 30 vol pct retained austenite containing at least 0.80 wt pct C was achieved with this alloy, which had tensile strengths up to 1650 MPa and tensile elongations around 20 pct.

  3. 3rd Quarter Transportation Report FY2015: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis B. [National Security Technologies, LLC (NSTec), Las Vegas, NV (United States)

    2015-07-01

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to and from the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2015 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments.

  4. Comparable Research of Energy and Ecology Parameters of 1st, 2nd and 3rd Generation Biofuels for Compression Ignition Engines

    National Research Council Canada - National Science Library

    Justas Zaglinskis

    2015-01-01

    .... Main attention focused on energy and environmental characteristics of diesel engine performance using 1st, 2nd and 3rd generation alcohol, fatty acid methyl and butyl esters blends with conventional diesel fuel (EN 590...

  5. Glossary of Educational Technology Terms. Second Edition, Revised and Enlarged = Glossaire des termes de technologie educative. Deuxieme edition, revue et augmentee.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    This glossary prepared by the International Council of Educational Media (ICEM) groups in one volume English and French terms related to educational technology in order to facilitate understanding of these terms, and to promote and encourage communication at the international level. Analysis of terms from the fields of audiovisual teaching,…

  6. Analysis and Design of a 3rd Order Velocity-Controlled Closed-Loop for MEMS Vibratory Gyroscopes

    Directory of Open Access Journals (Sweden)

    Ji-wei Jiao

    2013-09-01

    Full Text Available The time-average method currently available is limited to analyzing the specific performance of the automatic gain control-proportional and integral (AGC-PI based velocity-controlled closed-loop in a micro-electro-mechanical systems (MEMS vibratory gyroscope, since it is hard to solve nonlinear functions in the time domain when the control loop reaches to 3rd order. In this paper, we propose a linearization design approach to overcome this limitation by establishing a 3rd order linear model of the control loop and transferring the analysis to the frequency domain. Order reduction is applied on the built linear model’s transfer function by constructing a zero-pole doublet, and therefore mathematical expression of each control loop’s performance specification is obtained. Then an optimization methodology is summarized, which reveals that a robust, stable and swift control loop can be achieved by carefully selecting the system parameters following a priority order. Closed-loop drive circuits are designed and implemented using 0.35 μm complementary metal oxide semiconductor (CMOS process, and experiments carried out on a gyroscope prototype verify the optimization methodology that an optimized stability of the control loop can be achieved by constructing the zero-pole doublet, and disturbance rejection capability (D.R.C of the control loop can be improved by increasing the integral term.

  7. Analysis and design of a 3rd order velocity-controlled closed-loop for MEMS vibratory gyroscopes.

    Science.gov (United States)

    Wu, Huan-ming; Yang, Hai-gang; Yin, Tao; Jiao, Ji-wei

    2013-09-18

    The time-average method currently available is limited to analyzing the specific performance of the automatic gain control-proportional and integral (AGC-PI) based velocity-controlled closed-loop in a micro-electro-mechanical systems (MEMS) vibratory gyroscope, since it is hard to solve nonlinear functions in the time domain when the control loop reaches to 3rd order. In this paper, we propose a linearization design approach to overcome this limitation by establishing a 3rd order linear model of the control loop and transferring the analysis to the frequency domain. Order reduction is applied on the built linear model's transfer function by constructing a zero-pole doublet, and therefore mathematical expression of each control loop's performance specification is obtained. Then an optimization methodology is summarized, which reveals that a robust, stable and swift control loop can be achieved by carefully selecting the system parameters following a priority order. Closed-loop drive circuits are designed and implemented using 0.35 μm complementary metal oxide semiconductor (CMOS) process, and experiments carried out on a gyroscope prototype verify the optimization methodology that an optimized stability of the control loop can be achieved by constructing the zero-pole doublet, and disturbance rejection capability (D.R.C) of the control loop can be improved by increasing the integral term.

  8. Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.

    Science.gov (United States)

    He, Zhijian; Schulz, Anita; Wan, Xiaomeng; Seitz, Joshua; Bludau, Herdis; Alakhova, Daria Y; Darr, David B; Perou, Charles M; Jordan, Rainer; Ojima, Iwao; Kabanov, Alexander V; Luxenhofer, Robert

    2015-06-28

    The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance. Here, we present a method that overcomes both drawbacks in a very simple manner. We formulated 3rd generation taxoids, able to avoid common drug resistance mechanisms with doubly amphiphilic poly(2-oxazoline)s (POx), a safe and highly efficient polymer for the formulation of extremely hydrophobic drugs. We found excellent solubilization of different 3rd generation taxoids irrespective of the drug's chemical structures with essentially quantitative drug loading and final drug to polymer ratios around unity. The small, highly loaded micelles with a hydrodynamic diameter of less than 100nm are excellently suited for parenteral administration. Moreover, a selected formulation with the taxoid SB-T-1214 is about one to two orders of magnitude more active in vitro than paclitaxel in the multidrug resistant breast cancer cell line LCC6-MDR. In contrast, in wild-type LCC6, no difference was observed. Using a q4d×4 dosing regimen, we also found that POx/SB-T-1214 significantly inhibits the growth of LCC6-MDR orthotropic tumors, outperforming commercial paclitaxel drug Taxol and Cremophor EL formulated SB-T-1214. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. AN ANALYSIS OF STUDENTS’ SPEAKING ABILITY IN ENGLISH CONVERSATION CLUB (ECC PROGRAM AT THE 3rd SEMESTER

    Directory of Open Access Journals (Sweden)

    M. Fadhly Farhy Abbas

    2017-07-01

    Full Text Available This research is based on students’ speaking ability who had followed the EnglishConversation Club (ECC program especially for the third semester of English Department. Thepurpose of this study was to analyze the students’ speaking ability at the 3rd semester in the EnglishConversation Club FKIP UNILAK Pekanbaru. The type of the research was mixed method in typeof explanatory design. The number of participant was 53 students. The researcher used twoinstruments, those were test and interview. In analyzing the data, it used in descriptive statistics.The result of the analysis showed that the average score of 3rd semester students’ speaking abilitywas 45.42. It can be concluded that the students’ speaking ability was categorized into failed . Thescore of Standard Deviation was 7.02, Variance was 49.30, and Range was 36 points . It meansthat the students’ speaking ability was homogeneous. According to the Z-Score, it can be seen that49.06% students’ ability was higher than average and 50.94% students ability was below theaverage. In conclusion, the students’ ability in learning speaking English was failed, it had beenaffected by some factors, those were lack of vocabulary, grammar and motivation. It was supportedby the interview, eventhough the students’ perception to English Conversation Club (ECCprogram was positive, but in fact, the students’ frequency to speak English was seldom, they wereless practice speaking English everyday.Keywords : Speaking , English Conversation Club (ECC

  10. Preparation and Optimization of a Membrane for 3rd Generation Solvent Membrane Contactor

    OpenAIRE

    Arif, Asad

    2016-01-01

    Third generation solvent is a new class of CO2 absorbents with a great potential in terms of reduction of the regeneration energy requirement for post combustion carbon capture, but their use at the industrial scale is limited by their high volatility. Membrane contactor technology is proposed as possible solution, but the membrane layer must be purposely designed in order to act as amine barrier, without negatively affecting the overall CO2 mass transfer resistance. Teflon AF2400 has been re...

  11. 3rd International Conference on "Emerging Research in Computing, Information, Communication and Applications"

    CERN Document Server

    Prasad, NH; Nalini, N

    2015-01-01

    This proceedings volume covers the proceedings of ERCICA 2015. ERCICA provides an interdisciplinary forum for researchers, professional engineers and scientists, educators, and technologists to discuss, debate and promote research and technology in the upcoming areas of  Computing, Information, Communication and their Applications. The contents of this book cover emerging research areas in fields of Computing, Information, Communication and Applications. This will prove useful to both researchers and practicing engineers.

  12. 3rd congress on applied synthetic biology in Europe (Costa da Caparica, Portugal, February 2016).

    Science.gov (United States)

    Cueva, Miguel

    2017-03-25

    The third meeting organised by the European Federation of Biotechnology (EFB) on advances in Applied Synthetic Biotechnology in Europe (ASBE) was held in Costa da Caparica, Portugal, in February 2016. Abundant novel applications in synthetic biology were described in the six sessions of the meeting, which was divided into technology and tools for synthetic biology (I, II and III), bionanoscience, biosynthetic pathways and enzyme synthetic biology, and metabolic engineering and chemical manufacturing. The meeting presented numerous methods for the development of novel synthetic strains, synthetic biological tools and synthetic biology applications. With the aid of synthetic biology, production costs of chemicals, metabolites and food products are expected to decrease, by generating sustainable biochemical production of such resources. Also, such synthetic biological advances could be applied for medical purposes, as in pharmaceuticals and for biosensors. Recurrent, linked themes throughout the meeting were the shortage of resources, the world's transition into a bioeconomy, and how synthetic biology is helping tackle these issues through cutting-edge technologies. While there are still limitations in synthetic biology research, innovation is propelling the development of technology, the standardisation of synthetic biological tools and the use of suitable host organisms. These developments are laying a foundation to providing a future where cutting-edge research could generate potential solutions to society's pressing issues, thus incentivising a transition into a bioeconomy.

  13. Modern Physics, 4th edition

    Science.gov (United States)

    Tipler, Paul A.; Llewellyn, Ralph

    The new edition of the classic text for the intermediate-level modern physics course, revised and updated to take students to the forefront of contemporary research and applications across the full spectrum of science and technology."

  14. Development of human resources through the 3rd WNU Summer Institute

    Energy Technology Data Exchange (ETDEWEB)

    Min, B. J.; Kang, H. G. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Shin, J. H. [KAIST, Daejeon (Korea, Republic of); Lim, S. G. [Kyunghee University, Seoul (Korea, Republic of); Lee, A. R. [Hanyang University, Seoul (Korea, Republic of)

    2008-01-15

    WNU-SI(World Nuclear University - Summer Institute) is the six-week program designed to develop and inspire future international leaders in the field of nuclear science and technology. In 2007, three Korean young scientists had chances to participate by support of this project. The main purposes in this project are to promote abilities of young Korean nuclear professions, and to build the human network with future leaders in the world-wide nuclear field. The WNU-SI offered an intensive six-week program of lectures, group discussion, field trips, and team projects presented by some of the world's foremost authorities on the global environment and sustainable development, nuclear-related technology innovation, nuclear diplomacy, and nuclear industry operations. The programme is consisted of the following parts. -Lecture -Distinguished Speaker's Presentation -Group Discussion -Case Study -Issue Forum -Technical Tour -Cultural Events Lectures were given by 33 outstanding profession from international organizations, companies, universities and institutes around the world. It covered the wide ranges of subjects from technology to economics and politics. 11 working group were facilitated by Mentors, who are 14 from 8 different countries, to review and discuss about the each lecture subjects. Twice case studies and the issue forum were also main work in working group. The case study is the chance to find the solutions about some specific cases regarding lecture subject. The results was presented and evaluated with all the fellows, mentors and specialists in that field. In the issue forum, the participants selected the subjects they wanted to attend, and proceeded the term project for two weeks after technical tour. This program was one of the highlight in this programme. The final output was presented to the fellows, mentors, and specialists with a final summary report. The following issues were dealt with. -Options for storing radioactive waste -Advantages and

  15. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2017 (4th) Edition.

    Science.gov (United States)

    Soluk-Tekkeşin, Merva; Wright, John M

    2017-10-06

    The 4 th edition of the World Health Organization (WHO) Classification of Head and Neck Tumors was published in January 2017. The edition serves to provide an updated classification scheme, and extended genetic and molecular data that are useful as diagnostic tools for the lesions of the head and neck region. This review focuses on the most current update of odontogenic cysts and tumors based on the 2017 WHO edition. The updated classification has some important differences from the 3 rd edition (2005), including a new classification of odontogenic cysts, 'reclassified' odontogenic tumors, and some new entities.

  16. 3rd Euro-China Conference on Intelligent Data Analysis and Applications

    CERN Document Server

    Snášel, Václav; Sung, Tien-Wen; Wang, Xiao

    2017-01-01

    This book gathers papers presented at the ECC 2016, the Third Euro-China Conference on Intelligent Data Analysis and Applications, which was held in Fuzhou City, China from November 7 to 9, 2016. The aim of the ECC is to provide an internationally respected forum for scientific research in the broad areas of intelligent data analysis, computational intelligence, signal processing, and all associated applications of artificial intelligence (AI). The third installment of the ECC was jointly organized by Fujian University of Technology, China, and VSB-Technical University of Ostrava, Czech Republic. The conference was co-sponsored by Taiwan Association for Web Intelligence Consortium, and Immersion Co., Ltd.

  17. When 1st And 3rd Converge: A Border Region Framework

    Directory of Open Access Journals (Sweden)

    Leebrian Gaskins

    2011-03-01

    Full Text Available The U.S.-Mexico border region is unique in its social, legal, economic, political, and technological dynamics. Therefore, professionals moving from the interior of the U.S. or Mexico (or from other countries into the borderland region experience cross-cultural adjustment issues similar to those of expatriates. A quasi-expatriating model that takes into consideration the domestic adjustment and international expatriate adjustment literature addresses the unique adjustment dimensions that professional individuals experience in the US-Mexico border region.

  18. 3rd International Workshop on Intelligent Data Analysis and Management (IDAM)

    CERN Document Server

    Wang, Leon; Hong, Tzung-Pei; Yang, Hsin-Chang; Ting, I-Hsien

    2013-01-01

    These papers on Intelligent Data Analysis and Management (IDAM) examine issues related to the research and applications of Artificial Intelligence techniques in data analysis and management across a variety of disciplines. The papers derive from the 2013 IDAM conference in Kaohsiung ,Taiwan. It is an interdisciplinary research field involving academic researchers in information technologies, computer science, public policy, bioinformatics, medical informatics, and social and behavior studies, etc. The techniques studied include (but are not limited to): data visualization, data pre-processing, data engineering, database mining techniques, tools and applications, evolutionary algorithms, machine learning, neural nets, fuzzy logic, statistical pattern recognition, knowledge filtering, and post-processing, etc.

  19. Conference Report on the 3rd International Symposium on Lithium Application for Fusion Devices

    Science.gov (United States)

    Mazzitelli, G.; Hirooka, Y.; Hu, J. S.; Mirnov, S. V.; Nygren, R.; Shimada, M.; Ono, M.; Tabares, F. L.

    2015-02-01

    The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9-11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.

  20. 3rd and 4th Generation ECRIS:Some Possible Scenarios%第三代和第四代ECR离子源:未来展望

    Institute of Scientific and Technical Information of China (English)

    S.Gammino

    2007-01-01

    Since the end of '70s the Electron Cyclotron Resonance ion sources(ECRIS)allowed to increase both the energy and intensity of the beams available from different types of accelerators;perspectives for the ruture are still optimistic.It is commonly agreed that only some ECRIS parameters have been fully exploited,whether some others are still not efficiently used,or not understood.The developments in the last 20 years have followed the so called Standard Model and the availability of higher frequency generators and higher field magnets have permitted relevant increase;the use of Nb3Sn may extend the range.The availability of new schemes of microwave coupling to plasma is promising,and the focusing of the electromagnetic wave towards the chamber axis may improve the density of warm electron population.The paper will also describe some critical point of the 3rd generation ECRIS(including technological troubles and limits)and the scenario for future 4th generation ECRIS,operating at f=56-75GHz,to be built in 2010s.

  1. Growing expertise in Africa: CERN-UNESCO's 3rd Digital Library School

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    The third in the series of CERN-UNESCO African Schools on Digital Libraries took place in Dakar, Senegal, in November last year. The School represents an important opportunity for CERN to contribute to a global exchange of knowledge, skills and culture.   Ludmila Marian assisting participants during a hands-on computer session. More photographs available here. After Rwanda and Morocco, this time it was Senegal's turn to host the Digital Library School, the third of its kind, held from 21 to 25 November 2011. Participants from seven African French-speaking countries met at the Université Cheikh Anta Diop in Dakar to learn about digital libraries and the importance of new technologies in the dissemination of knowledge by libraries. The School outlined the principles of digital information management and showcased the Invenio software, developed by CERN to manage digital libraries and freely available as Open Source software. The series of Schools, which combine in...

  2. 3rd International Conference on Advanced Engineering : Theory and Applications 2016

    CERN Document Server

    Dao, Tran; Kim, Sang; Tien, Nguyen; Zelinka, Ivan

    2017-01-01

    These lecture notes present selected topics concerning a wide range of electrical and electronics applications, highlighting innovative approaches and offering state-of-the-art overviews. The book is divided into 14 topical areas, including e.g. telecommunication, power systems, robotics, control systems, renewable energy, mechanical engineering, computer science and more. Readers will find revealing papers on the design and implementation of control algorithms for automobiles and electrohydraulic systems, efficient protocols for vehicular ad hoc networks and motor control, and energy-saving methods that can be applied in various fields of electrical engineering. The book offers a valuable resource for all practitioners who want to apply the topics discussed to solve real-world problems in their challenging applications. Offering insights into common and related subjects in the research fields of modern electrical, electronic and related technologies, it will also benefit all scientists and engineers working ...

  3. 3rd International Conference on INformation Systems Design and Intelligent Applications

    CERN Document Server

    Mandal, Jyotsna; Udgata, Siba; Bhateja, Vikrant

    2016-01-01

    The third international conference on INformation Systems Design and Intelligent Applications (INDIA – 2016) held in Visakhapatnam, India during January 8-9, 2016. The book covers all aspects of information system design, computer science and technology, general sciences, and educational research. Upon a double blind review process, a number of high quality papers are selected and collected in the book, which is composed of three different volumes, and covers a variety of topics, including natural language processing, artificial intelligence, security and privacy, communications, wireless and sensor networks, microelectronics, circuit and systems, machine learning, soft computing, mobile computing and applications, cloud computing, software engineering, graphics and image processing, rural engineering, e-commerce, e-governance, business computing, molecular computing, nano-computing, chemical computing, intelligent computing for GIS and remote sensing, bio-informatics and bio-computing. These fields are not...

  4. Advanced Technology in Teaching : Proceedings of the 2009 3rd International Conference on Teaching and Computational Science, v.1

    CERN Document Server

    Intelligent Ubiquitous Computing and Education

    2012-01-01

    The volume includes a set of selected papers extended and revised from the International Conference on Teaching and Computational Science (WTCS 2009) held on December 19- 20, 2009, Shenzhen, China.   WTCS 2009 best papers Volume 1 is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of Intelligent Ubiquitous Computing and Education to disseminate their latest research results and exchange views on the future research directions of these fields. 128 high-quality papers are included in the volume. Each paper has been peer-reviewed by at least 2 program committee members and selected by the volume editor Prof.Wu.   On behalf of the WTCS 2009, we would like to express our sincere appreciation to all of authors and referees for their efforts reviewing the papers. Hoping you can find lots of profound research ideas and results on the related fields of Intelligent Ubiquitous Computing and Education.

  5. Advanced Technology in Teaching : Proceedings of the 2009 3rd International Conference on Teaching and Computational Science, v.2

    CERN Document Server

    Education, Psychology and Computer Science

    2012-01-01

    The volume includes a set of selected papers extended and revised from the International Conference on Teaching and Computational Science (WTCS 2009) held on December 19- 20, 2009, Shenzhen, China.   WTCS 2009 best papers Volume 2 is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of Education, Psychology and Computer Science to disseminate their latest research results and exchange views on the future research directions of these fields. 128 high-quality papers are included in the volume. Each paper has been peer-reviewed by at least 2 program committee members and selected by the volume editor Prof. Wu.   On behalf of the WTCS 2009, we would like to express our sincere appreciation to all of authors and referees for their efforts reviewing the papers. Hoping you can find lots of profound research ideas and results on the related fields of Education, Psychology and Computer Science. 

  6. Color Portion of Solar Radiation in the Partial Annular Solar Eclipse, October 3rd, 2005, at Helwan, Egypt

    Directory of Open Access Journals (Sweden)

    A. H. Hassan

    2010-01-01

    Full Text Available Measurements were made of various solar radiation components, global, direct and diffuse and their fractions during the partial annular solar eclipse on October 3rd, 2005 at Helwan, Egypt (Lat. 29.866◦ N and Long. 31.20◦ E, and an analysis has been made. The duration of the solar eclipse was 3 h 17 min, and the maximum magnitude of the eclipse in this region was 0.65. The optical depth of the direct component and the relative humidity decreased, while both the transparency and the air temperature increased towards the maximum eclipse. The general trends of the global components are decreasing optical depth and increasing transparency between the first contact and the last contact. The prevailing color during the eclipse duration was diffused infrared (77 % of the total diffuse radiation level.

  7. Use of 2nd and 3rd Level Correlation Analysis for Studying Degradation in Polycrystalline Thin-Film Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Albin, D. S.; del Cueto, J. A.; Demtsu, S. H.; Bansal, S.

    2011-03-01

    The correlation of stress-induced changes in the performance of laboratory-made CdTe solar cells with various 2nd and 3rd level metrics is discussed. The overall behavior of aggregated data showing how cell efficiency changes as a function of open-circuit voltage (Voc), short-circuit current density (Jsc), and fill factor (FF) is explained using a two-diode, PSpice model in which degradation is simulated by systematically changing model parameters. FF shows the highest correlation with performance during stress, and is subsequently shown to be most affected by shunt resistance, recombination and in some cases voltage-dependent collection. Large decreases in Jsc as well as increasing rates of Voc degradation are related to voltage-dependent collection effects and catastrophic shunting respectively. Large decreases in Voc in the absence of catastrophic shunting are attributed to increased recombination. The relevance of capacitance-derived data correlated with both Voc and FF is discussed.

  8. THE 3rd SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 14-18 APRIL 2012, FLORENCE, ITALY: SUMMARIES OF ORAL SESSIONS

    Science.gov (United States)

    Abbs, Brandon; Achalia, Rashmin M; Adelufosi, Adegoke O; Aktener, Ahmet Yiğit; Beveridge, Natalie J; Bhakta, Savita G; Blackman, Rachael K; Bora, Emre; Byun, MS; Cabanis, Maurice; Carrion, Ricardo; Castellani, Christina A; Chow, Tze Jen; Dmitrzak-Weglarz, M; Gayer-Anderson, Charlotte; Gomes, Felipe V; Haut, Kristen; Hori, Hiroaki; Kantrowitz, Joshua T; Kishimoto, Taishiro; Lee, Frankie HF; Lin, Ashleigh; Palaniyappan, Lena; Quan, Meina; Rubio, Maria D; Ruiz de Azúa, Sonia; Sahoo, Saddichha; Strauss, Gregory P; Szczepankiewicz, Aleksandra; Thompson, Andrew D; Trotta, Antonella; Tully, Laura M; Uchida, Hiroyuki; Velthorst, Eva; Young, Jared W; O’Shea, Anne; DeLisi, Lynn E.

    2013-01-01

    The 3rd Schizophrenia International Research Society Conference was held in Florence, Italy, April 14-18, 2012.and this year had as its emphasis, “The Globalization of Research”. Student travel awardees served as rapporteurs for each oral session and focused their summaries on the most significant findings that emerged and the discussions that followed. The following report is a composite of these summaries. We hope that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:22910407

  9. Steel Structure Technology in 2010 Edition Ten New Technologies of Buildings%《建筑业10项新技术》(2010版)之钢结构技术

    Institute of Scientific and Technical Information of China (English)

    李景芳

    2011-01-01

    (2010版)之钢结构技术包括9项内容:深化设计技术、厚钢板焊接技术、大型钢结构滑移安装施工技术、钢结构与大型设备计算机控制整体顶升与提升安装施工技术、钢与混凝土组合结构技术、住宅钢结构技术、高强度钢材应用技术、大型复杂膜结构施工技术、模块式钢结构框架组装吊装技术等.主要介绍了各部分的研究与发展、主要技术要点以及工程应用.%Steel structure technology in 2010 edition Ten New Technologies of Buildings includes nine contents, which are deep design technology, welding technology for thick steel plate, sliding and installation construction technology for large steel structures, integral lifting and hoisting installation technology controlled by computer for steel structures and large equipment, combination structure technology for steel and concrete, residence steel structures technology, application technology for high strength steel materials, construction technology for large complex membrane structures, assembly and hoisting technology for module-type steel frame. The study and development, key technology points and engineering application are introduced in detail.

  10. Innovative Strategies for Enhancing Geoscience: Lesson Plans from the 3rd Millennium B.C.E.

    Science.gov (United States)

    Romani, P. N.; Bartholomew, I.; Frank, M.; Hackett, K.; Jackson, T.; Melzer, S.; 6th Grade,

    2002-05-01

    Each year the fifth and sixth grade students at Glenarden Woods Elementary Magnet School for Talented and Gifted (TAG) Students, in Glenarden, Maryland study an ancient culture to provide a unifying theme to their studies. The thematic unit is year-long and involves language arts, social studies, and art. Originally, the curriculum did not include any math or science, but for the past seven years we have been working to integrate the technology of the ancient culture into the program. Our goals are to keep the science as hands on as possible and to have the students learn by solving problems. This year's culture was ancient Egypt and the math and science components had a distinctive geoscience flavor to them. The initial problem for the students was to how to lay out a pyramid so that the four sides were aligned with the four cardinal directions as the pyramids are in Egypt. In keeping with the spirit of their studies they had to do so as the Egyptians did, i.e. without a pole star and without the use of any "modern" conveniences such as compasses, global positioning systems, etc. The problem was solved by measurements and observations of a gnomon's shadow. This work then provided a nice springboard for their next problem, duplicating Eratosthenes's measurement of the circumference of the Earth. Eratosthenes was a Greek who lived and experimented in Egypt in the Ptolemaic era. His determination of the Earth's circumference was within 15% of the modern day value. For this work the students had to team with other elementary students in Amherst, Massachusetts. We will present how we did the projects and lessons learned.

  11. PREFACE: The 3rd ISESCO International Workshop and Conference On Nanotechnology 2012 (IWCN2012)

    Science.gov (United States)

    Umar, Akrajas Ali; Yahaya, Muhammad; Mat Salleh, Muhamad

    2013-04-01

    The ISESCO Conference on Nanomaterials and Applications (IWCN2012) is one of a series of nanotechnology seminars organized by ISESCO, Malaysian Solid State Science and Technology Society (MASS), the Universiti Kebangsaan Malaysia. IWCN2012 is the third seminar, following IWCN2007 and IWCN2010, held in the Universiti Kebangsaaan Malaysia, Bangi Malaysia from 5-7 December 2012. The conference was attended by more than 250 participants from 15 countries, including 150 students. The conference and workshop provided a forum for researchers and students, policymakers and other professionals especially from the ISESCO Member States to exchange information, enhance understanding and more importantly to engage in the development of new nanoscience and nanotechnology research in multidisciplinary areas in physics, chemistry and biology. Together with the conference, the third Meeting of the ISESCO Expert Panel on Nanotechnology was held to chart the future activities in Nanoscience and Nanotechnology in ISESCO member countries. The objective of the conference is to communicate and discuss recent progress in nanoscience and nanotechnology research and its potential applications in future economic growth. The main focus for the present activity is on energy and environment. The conference received 105 papers in total and 50 of them were selected to be considered for publication in Journal of Physics: Conference Series. However, finally, after undergoing vigorous and thorough revisions by respected editors and reviewers in the fields, 29 papers were accepted. This volume covers the follwing topics: Nanomaterials Synthesis and Characterization Nanomaterials for Energy and Catalysis Nanoelectronics, Sensors and MEMS Devices Nanophotonics We are indebted to all the keynote speakers, invited speakers, participant and authors for their contribution to this event. Their contribution has led to the success of this conference. We are also very grateful for the time, effort and

  12. U.S. Army War College Guide to National Security Issues. Volume 2: National Security Policy and Strategy. 3rd Edition

    Science.gov (United States)

    2008-06-01

    from USCINCSOUTH, June 8, 1994, from Embassy La Paz, and June 9, 1994, from Embassy Bogota . 29. The classic study of the role of culture and turf in...both geographically and culturally, of a greater Europe. Ukraine’s population is divided politically along the line of the Dnipro River , with the

  13. Test methods for evaluating solid waste. Volume 1A through 1C, and Volume 2. Field manual physical/chemical methods (3rd edition)

    Energy Technology Data Exchange (ETDEWEB)

    1986-09-01

    This manual provides test procedures that may be used to evaluate those properties of a solid waste that determine whether the waste is a hazardous waste within the definition of Section 3001 of the Resource Conservation and Recovery Act (PL 94-580). These methods are approved for obtaining data to satisfy the requirement of 40 CFR Part 261, Identification and Listing of Hazardous Waste. Volume IA deals with quality control, selection of appropriate test methods, and analytical methods for metallic species. Volume IB consists of methods for organic analytes. Volume IC includes a variety of test methods for miscellaneous analytes and properties for use in evaluating the waste characteristics. Volume II deals with sample acquisition and includes quality control, sampling-plan design and implementation, and field-sampling methods.

  14. U.S. Army War College Guide to National Security Issues. Volume 1: Theory of War and Strategy. 3rd Edition

    Science.gov (United States)

    2008-06-01

    Army War College, 2007, pp. 47-75. 23. Meinhart , p. 44. 24. David Jablonsky, "National Power," in U.S. Army War College Guide to National Security...U.S AmyWar CaUawge Guide to-National Security issues Vnlumn I: Theory of War amd Strategy it 2008 Ed ied hy J. Bo n atolnes’ r U.S. ARMY WAR COLLEGE...20080709 281 The views expressed in this report are those of the authors and do not necessarily reflect the official policy or position of the U.S. Army

  15. FOREWORD: 3rd Symposium on Large TPCs for Low Energy Event Detection

    Science.gov (United States)

    Irastorza, Igor G.; Colas, Paul; Gorodetzky, Phillippe

    2007-05-01

    The Third International Symposium on large TPCs for low-energy rare-event detection was held at Carré des sciences, Poincaré auditorium, 25 rue de la Montagne Ste Geneviève in Paris on 11 12 December 2006. This prestigious location belonging to the Ministry of Research is hosted in the former Ecole Polytechnique. The meeting, held in Paris every two years, gathers a significant community of physicists involved in rare event detection. Its purpose is an extensive discussion of present and future projects using large TPCs for low energy, low background detection of rare events (low-energy neutrinos, dark matter, solar axions). The use of a new generation of Micro-Pattern Gaseous Detectors (MPGD) appears to be a promising way to reach this goal. The program this year was enriched by a new session devoted to the detection challenge of polarized gamma rays, relevant novel experimental techniques and the impact on particle physics, astrophysics and astronomy. A very particular feature of this conference is the large variety of talks ranging from purely theoretical to purely experimental subjects including novel technological aspects. This allows discussion and exchange of useful information and new ideas that are emerging to address particle physics experimental challenges. The scientific highlights at the Symposium came on many fronts: Status of low-energy neutrino physics and double-beta decay New ideas on double-beta decay experiments Gamma ray polarization measurement combining high-precision TPCs with MPGD read-out Dark Matter challenges in both axion and WIMP search with new emerging ideas for detection improvements Progress in gaseous and liquid TPCs for rare event detection Georges Charpak opened the meeting with a talk on gaseous detectors for applications in the bio-medical field. He also underlined the importance of new MPGD detectors for both physics and applications. There were about 100 registered participants at the symposium. The successful

  16. Cluster editing

    DEFF Research Database (Denmark)

    Böcker, S.; Baumbach, Jan

    2013-01-01

    . The problem has been the inspiration for numerous algorithms in bioinformatics, aiming at clustering entities such as genes, proteins, phenotypes, or patients. In this paper, we review exact and heuristic methods that have been proposed for the Cluster Editing problem, and also applications......The Cluster Editing problem asks to transform a graph into a disjoint union of cliques using a minimum number of edge modifications. Although the problem has been proven NP-complete several times, it has nevertheless attracted much research both from the theoretical and the applied side...

  17. 数字音频技术编辑软件设计构建研究%Digital Audio Technology Editing Software Design Construction

    Institute of Scientific and Technical Information of China (English)

    赵美玉

    2014-01-01

    随着计算机技术和数字音频技术的飞速发展,计算机技术和电子技术已渗入到各行各业,各种各样方便人们使用的不同用途的软件也大量应运而生,音乐制作方面也不例外。在数字化发展如此快的年代,通过现有技术,MIDI功能就已经到了一个非常完善的程度。电脑音乐给有想象力的人们带来了很宽广的创作空间。伴随着广播电台的数字化建设不断快速推进,广播音频编辑软件结合了计算机技术与数字音频技术,在我国广播电台中得到了广泛应用,因此,我们相信在今后的数字广播的发展中,可以提供更高质量、更多声道的多声道数字音频系统。本文对音频编辑软件的特效、数字音频制作软件设计构建进行了研究分析。%With the rapid development of computer technology and digital audio technology, computer technology and elec-tronic technology has penetrated into all walks of life, using a variety of convenient for people to the different uses of the sof-tware also emerge as the times require, making music is no exception. In the digital age is growing so fast, the existing tech-nology, the MIDI function will have reached a very perfect degree. Computer music brings a broad creative space to people with imagination. Along with the construction of digital radio rapidly advancing, broadcast audio editing software combines computer technology and digital audio technology, in a radio broadcast in China has been widely applied, therefore, we be-lieve that in the development of digital radio in the future, multi-channel digital audio system can provide more high quality, more channels. Effects of digital audio, the audio editing software software design are studied.

  18. Developmental competence of porcine genome-edited zygotes.

    Science.gov (United States)

    Gil, Maria A; Martinez, Cristina A; Nohalez, Alicia; Parrilla, Inmaculada; Roca, Jordi; Wu, Jun; Ross, Pablo J; Cuello, Cristina; Izpisua, Juan C; Martinez, Emilio A

    2017-09-01

    Genome editing in pigs has tremendous practical applications for biomedicine. The advent of genome editing technology, with its use of site-specific nucleases-including ZFNs, TALENs, and the CRISPR/Cas9 system-has popularized targeted zygote genome editing via one-step microinjection in several mammalian species. Here, we review methods to optimize the developmental competence of genome-edited porcine embryos and strategies to improve the zygote genome-editing efficiency in pigs. © 2017 Wiley Periodicals, Inc.

  19. Multilinguals and Wikipedia Editing

    CERN Document Server

    Hale, Scott A

    2013-01-01

    This article analyzes one month of edits to Wikipedia in order to examine the role of users editing multiple language editions (referred to as multilingual users). Such multilingual users may serve an important function in diffusing information across different language editions of the project, and prior work has suggested this could reduce the level of self-focus bias in each edition. This study finds multilingual users are much more active than their single-edition (monolingual) counterparts. They are found in all language editions, but smaller-sized editions with fewer users have a higher percentage of multilingual users than larger-sized editions. About a quarter of multilingual users always edit the same articles in multiple languages, while just over 40% of multilingual users edit different articles in different languages. When non-English users do edit a second language edition, that edition is most frequently English. Nonetheless, several regional and linguistic cross-editing patterns are also present...

  20. 3rd SAGA Workshop

    CERN Document Server

    Conti, Giuseppe

    2014-01-01

    Mathematical algorithms are a fundamental component of Computer Aided Design and Manufacturing (CAD/CAM) systems. This book provides a bridge between algebraic geometry and geometric modelling algorithms, formulated within a computer science framework. Apart from the algebraic geometry topics covered, the entire book is based on the unifying concept of using algebraic techniques – properly specialized to solve geometric problems – to seriously improve accuracy, robustness and efficiency of CAD-systems. It provides new approaches as well as industrial applications to deform surfaces when animating virtual characters, to automatically compare images of handwritten signatures, and to improve control of NC machines. This book further introduces a noteworthy representation based on 2D contours, which is essential to model the metal sheet in industrial processes. It additionally reviews applications of numerical algebraic geometry to differential equations systems with multiple solutions and bifurcations. Futur...

  1. 3rd Cryocooler Conference

    CERN Document Server

    Louie, Berverly; McCarthy, Sandy

    1985-01-01

    Cryocoolers 3 documents the output of the Third Cryocooler Conference, held at the National Bureau of Standards, Boulder, Colorado, on September 17-18, 1984. About 140 people from 10 countries attended the conference representing industry, government, and academia. A total of 26 papers were presented orally at the conference and all appear in written form in the proceedings. The focus of this conference was on small cryocoolers in the temperature range of 4 - 80 K. Mechanical and nonmechanical types are discussed in the various papers. Applications of these small cryocoolers include the cooling of infrared detectors, cryopumps, small superconducting devices and magnets, and electronic devices. The conference proceedings reproduced here was published by the National Bureau of Standards in Boulder, Colorado as NBS Special Publication #698.

  2. 3rd Dynamics Days

    CERN Document Server

    Clerc, Marcel

    2016-01-01

    This book presents recent advances, new ideas and novel techniques related to the field of nonlinear dynamics, including localized pattern formation, self-organization and chaos. Various natural systems ranging from nonlinear optics to mechanics, fluids and magnetic are considered. The aim of this book is to gather specialists from these various fields of research to promote cross-fertilization and transfer of knowledge between these active research areas. In particular, nonlinear optics and laser physics constitute an important part in this issue due to the potential applications for all-optical control of light, optical storage, and information processing. Other possible applications include the generation of ultra-short pulses using all-fiber cavities.

  3. 3rd Abel Symposium

    CERN Document Server

    Owren, Brynjulf

    2008-01-01

    The 2006 Abel symposium is focusing on contemporary research involving interaction between computer science, computational science and mathematics. In recent years, computation has been affecting pure mathematics in fundamental ways. Conversely, ideas and methods of pure mathematics are becoming increasingly important within computational and applied mathematics. At the core of computer science is the study of computability and complexity for discrete mathematical structures. Studying the foundations of computational mathematics raises similar questions concerning continuous mathematical structures. There are several reasons for these developments. The exponential growth of computing power is bringing computational methods into ever new application areas. Equally important is the advance of software and programming languages, which to an increasing degree allows the representation of abstract mathematical structures in program code. Symbolic computing is bringing algorithms from mathematical analysis into the...

  4. [Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

    Science.gov (United States)

    Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

    2010-01-01

    The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

  5. To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm

    Science.gov (United States)

    Wollheim, Frank A

    2002-01-01

    The 3rd Annual EULAR Congress, held in Stockholm on 12–15 June 2002, had a turnout of 8300 delegates, almost identical to last year's record attendance level in Prague. The venue was close to ideal, allowing ample space for poster sessions in the exhibition hall. The manned poster sessions were well attended, even on the last day of the Congress. The numerous invited speakers represented the world's elite, allowing the staging of excellent state-of-the-art podium sessions. The aim of attracting the young scientific community was partly achieved, but individual delegates' dependence on industry sponsorship poses potential problems. The organization was a big improvement compared to that of the two previous congresses. Approximately 1800 abstracts were submitted, an increase of 50%, resulting in a higher quality of accepted abstracts. The satellite symposia held every morning and late afternoon were well attended; thus, industry exposure of new products, both in podium sessions and at the exhibitions, was well accommodated. The Annual EULAR Congress consolidates its position as one of the two most important annual congresses of rheumatology, but EULAR economy and commercial aspects are still too dominant in relation to science. PMID:12223107

  6. See the light: electrophysiological characterization of the Bolwig organ's light response of Calliphora vicina 3rd instar larvae.

    Science.gov (United States)

    Hinnemann, Axel; Niederegger, Senta; Hanslik, Ulrike; Heinzel, H-G; Spiess, Roland

    2010-11-01

    The anatomy and development of the larval cyclorraphous Diptera visual system is well established. It consists of the internal Bolwig organ (BO), and the associated nerve connecting it to the brain. The BO contributes to various larval behaviors but was never electrophysiologically characterized. We recorded extracellulary from the Bolwig nerve of 3rd instar Calliphora vicina larvae to quantify the sensory response caused by BO stimulation with light stimuli of different wavelengths, intensities and directions. Consistent with previous behavioral experiments we found the BO most sensitive to white and green, followed by blue, yellow, violet and red light. The BO showed a phasic-tonic response curve. Increasing light intensity produced a sigmoid response curve with an approximate threshold of 0.0105 nW/cm(2) and a dynamic range from 0.105 nW/cm(2) to 52.5 nW/cm(2). No differences exist between feeding and wandering larvae which display opposed phototaxis. This excludes reduced BO sensitivity from causing the switch in behavior. Correlating to the morphology of the BO frontal light evoked the maximal reaction, while lateral light reduced the neural response asymmetrically: Light applied ipsilaterally to the recorded BO always produced a stronger response than when applied from the contralateral side. This implies that phototacic behavior is based on a tropotactic mechanism.

  7. Evaluation of a model of dissertation supervision for 3rd year B.Sc. undergraduate nursing students.

    Science.gov (United States)

    Scholefield, Donna; Cox, Georgina

    2016-03-01

    All English universities now offer an all degree undergraduate nursing programme. Many currently use an individual supervision model to support final year dissertation students, but with increased numbers and limited resources new models of supervision are needed. This study evaluated a mixed (group and individual) model of dissertation supervision to determine its effectiveness for a large group of undergraduate nursing students. A sample of 3rd year students and their supervisors were selected from one large university. An evaluation survey was conducted using anonymous internet-based questionnaires and focus groups. The data was analysed using Survey Monkey, SPSS and thematic analysis. A 51% (n = 56/110) response rate (students) and 65% (n = 24/37) for supervisors was obtained. The majority of students and supervisors were satisfied with the new model. There was a mixed response to the group workshops and supervision groups. Three themes emerged from the qualitative data: engaging with the process, motivation to supervise and valuing the process. The supervision process is a struggle but both parties gained considerably from going through the process. In conclusion, a mixed model of supervision together with a range of other learning resources can be an effective approach in supporting students through the dissertation process.

  8. From Bottom to Top: Identification to Precision Measurement of 3rd-Generation Quarks with the ATLAS Detector

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00335926

    The 3rd-generation quarks, bottom ($b$) and top ($t$), are recent additions to the Standard Model of particle physics, and precise characterization of their properties have important implications to searching for new physics phenomena. This thesis presents two analyses which use 4.6 fb$^{-1}$ of $pp$ collision data at $\\sqrt{s} = 7$ TeV collected by the ATLAS detector at the Large Hadron Collider (LHC) to measure their properties. The first is an analysis which measures our ability to identify jets originating from $b$ quarks with machine-learning algorithms applied to simulated and real data, so the result in simulation can be corrected to match that in data. This measurement has implications for our ability to identify processes with b quarks in their final state; $t$ quarks decay to a $b$ quark and a weak vector boson $W$ more than 99% of the time. The second analysis presented measures properties of the $t \\rightarrow Wb$ decay channel associated with phenomena not predicted by the Standard Model, through...

  9. The 3rd Canadian Symposium on Hepatitis C Virus: Expanding Care in the Interferon-Free Era

    Directory of Open Access Journals (Sweden)

    Sonya A MacParland

    2014-01-01

    Full Text Available Hepatitis C virus (HCV currently infects approximately 250,000 individuals in Canada and causes more years of life lost than any other infectious disease in the country. In August 2011, new therapies were approved by Health Canada that have achieved higher response rates among those treated, but are poorly tolerated. By 2014/2015, short-course, well-tolerated treatments with cure rates >95% will be available. However, treatment uptake is poor due to structural, financial, geographical, cultural and social barriers. As such, ‘Barriers to access to HCV care in Canada’ is a crucial topic that must be addressed to decrease HCV disease burden and potentially eliminate HCV in Canada. Understanding how to better care for HCV-infected individuals requires integration across multiple disciplines including researchers, clinical services and policy makers to address the major populations affected by HCV including people who inject drugs, baby boomers, immigrants and Aboriginal and/or First Nations people. In 2012, the National CIHR Research Training Program in Hepatitis C organized the 1st Canadian Symposium on Hepatitis C Virus (CSHCV in Montreal, Quebec. The 2nd CSHCV was held in 2013 in Victoria, British Columbia. Both symposia were highly successful, attracting leading international faculty with excellent attendance leading to dialogue and knowledge translation among attendees of diverse backgrounds. The current article summarizes the 3rd CSHCV, held February 2014, in Toronto, Ontario.

  10. When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?

    Science.gov (United States)

    Soysal, Pinar; Aydin, Ali Ekrem; Koc Okudur, Saadet; Isik, Ahmet Turan

    2016-01-01

    Detection of orthostatic hypotension (OH) is very important in geriatric practice, since OH is associated with mortality, ischemic stroke, falls, cognitive failure and depression. It was aimed to determine the most appropriate time for measuring blood pressure in transition from supine to upright position in order to diagnose OH in elderly. Comprehensive geriatric assessment (CGA) including Head up Tilt Table (HUT) test was performed in 407 geriatric patients. Orthostatic changes were assessed separately for the 1st, 3rd and 5th minutes (HUT1, HUT3 and HUT5, respectively) taking the data in supine position as the basis. The mean age, recurrent falls, presence of dementia and Parkinson's disease, number of drugs, alpha-blocker and anti-dementia drug use, and fasting blood glucose levels were significantly higher in the patients with versus without OH; whereas, albumin and 25-hydroxy vitamin D levels were significantly lower (pfasting blood glucose level was prominent in HUT1 as compared to HUT3 (p<0.01, p<0.05). Comparison of the patients that had OH only in HUT1, HUT3or HUT5 revealed no difference in terms of CGA parameters. These results suggests that orthostatic blood pressure changes determined at the 1st minute might be more important for geriatric practice. Moreover, 1st minute measurement might be more convenient in the elderly as it requires shorter time in practice.

  11. Ultrastructure of the ovary of Dermatobia hominis (Diptera: cuterebridae. I. Development during the 3rd larval instar

    Directory of Open Access Journals (Sweden)

    E. A. Gregorio

    1990-09-01

    Full Text Available The ultrastructure and distribution of gonial and somatic cells in the ovary of Dermatobia hominis was studied during the 3rd larval instar. In larvae weighing between 400 and 500 mg, the ovary is partially divided into basal and apical regions by oblong somatic cells that penetrate from the periphery; these cells show ovoid nucleus and cytoplasm full of microtubules. In both regions, gonial cells with regular outlines, large nucleus and low electron-density cytoplasm are scattered among the interstitial somatic cells. These later cells have small nucleus and electrodense cytoplasm. Clear somatic cells with small nucleus and cytoplasm of very low electron-density are restrict to the apical region of the gonad. Degenerating interstitial somatic cells are seen in the basal portion close to the ovary peduncle. During all this larval period the morphological features of the ovary remain almost the same. At the end of the period there is a gradual deposition of glycogen in the cytoplasm of the somatic cells, increase in the number and density of their mitochondria plus nuclear modification as membrane wrinkling and chromatin condensation in masses.

  12. Development of partially-coherent wavefront propagation simulation methods for 3rd and 4th generation synchrotron radiation sources

    Science.gov (United States)

    Chubar, Oleg; Berman, Lonny; Chu, Yong S.; Fluerasu, Andrei; Hulbert, Steve; Idir, Mourad; Kaznatcheev, Konstantine; Shapiro, David; Shen, Qun; Baltser, Jana

    2011-09-01

    Partially-coherent wavefront propagation calculations have proven to be feasible and very beneficial in the design of beamlines for 3rd and 4th generation Synchrotron Radiation (SR) sources. These types of calculations use the framework of classical electrodynamics for the description, on the same accuracy level, of the emission by relativistic electrons moving in magnetic fields of accelerators, and the propagation of the emitted radiation wavefronts through beamline optical elements. This enables accurate prediction of performance characteristics for beamlines exploiting high SR brightness and/or high spectral flux. Detailed analysis of radiation degree of coherence, offered by the partially-coherent wavefront propagation method, is of paramount importance for modern storage-ring based SR sources, which, thanks to extremely small sub-nanometer-level electron beam emittances, produce substantial portions of coherent flux in X-ray spectral range. We describe the general approach to partially-coherent SR wavefront propagation simulations and present examples of such simulations performed using "Synchrotron Radiation Workshop" (SRW) code for the parameters of hard X-ray undulator based beamlines at the National Synchrotron Light Source II (NSLS-II), Brookhaven National Laboratory. These examples illustrate general characteristics of partially-coherent undulator radiation beams in low-emittance SR sources, and demonstrate advantages of applying high-accuracy physical-optics simulations to the optimization and performance prediction of X-ray optical beamlines in these new sources.

  13. Palaeopathology of human remains of the 1st century BC–3rd century AD from Armenia (Beniamin, Shirakavan I

    Directory of Open Access Journals (Sweden)

    Khudaverdyan Anahit Yu.

    2015-06-01

    Full Text Available The aim of this article was to document the pathology of the individuals from the archeological sites of Beniamin and Shirakavan I, Armenia, dated on the 1st century BC - 3rd century AD. The findings revealed that two groups differed in mean age at death of adults. At Beniamin it was 24 years, 40.8 years for males and 30.9 years for females, whereas at Shirakavanit it was 29.3 years, 29.6 years for males and 35.8 years for females. The greatest mortality appeared to have occurred when the children reached the age of one year (Beniamin. The population had high number of young-adult females with a cause of death associated with child-bearing. Very few females survived to old age. Traumatic conditions (63.64% and enamel hypoplasias (57.2% have a high frequency in the skeletal material from Shirakavan. The volume of selection of Shirakavan does not allow itself to so big discussion as it was possible with the Beniamin site. Fewer hypoplasias in Beniamin group indicate that food resources were more abundant and more easily exploited. The small frequency of a periodontal disorder indicates that dental hygiene was good during the Antiquity period. We here report a case of possible pituitary dwarfism and a case of decapitation.

  14. The ESO/VLT 3rd year Type Ia supernova data set from the Supernova Legacy Survey

    CERN Document Server

    Balland, C; Basa, S; Mouchet, M; Howell, D A; Astier, P; Carlberg, R G; Conley, A; Fouchez, D; Guy, J; Hardin, D; Hook, I M; Pain, R; Perrett, K; Pritchet, C J; Regnault, N; Rich, J; Sullivan, M; Antilogus, P; Arsenijevic, V; Du, J Le; Fabbro, S; Lidman, C; Mourao, A; Palanque-Delabrouille, Nathalie; Pécontal, E; Ruhlmann-Kleider, V

    2009-01-01

    We present 139 spectra of 124 Type Ia supernovae (SNeIa) that were observed at the ESO/VLT during the first three years of the Canada-France-Hawai Telescope (CFHT) Supernova Legacy Survey (SNLS). This homogeneous data set is used to test for redshift evolution of SNeIa spectra, and will be used in the SNLS 3rd year cosmological analyses. Spectra have been reduced and extracted with a dedicated pipeline that uses photometric information from deep CFHT Legacy Survey (CFHT-LS) reference images to trace, at sub-pixel accuracy, the position of the supernova on the spectrogram as a function of wavelength. It also separates the supernova and its host light in 60% of cases. The identification of the supernova candidates is performed using a spectrophotometric SNIa model. A total of 124 SNeIa, roughly 50% of the overall SNLS spectroscopic sample, have been identified using the ESO/VLT during the first three years of the survey. Their redshifts range from z=0.149 to z=1.031. The average redshift of the sample is z=0.63...

  15. 3rd Quarter Transportation Report FY 2014: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2014-09-20

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2014 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. This report also includes annual summaries for FY 2014 in Tables 4 and 5. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report do not include minor volumes of non-radioactive materials that were approved for disposal. Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to differing rounding conventions.

  16. Influence of radiofrequency-electromagnetic waves from 3rd-generation cellular phones on fertilization and embryo development in mice.

    Science.gov (United States)

    Suzuki, Satoshi; Okutsu, Miho; Suganuma, Ryota; Komiya, Hiromi; Nakatani-Enomoto, Setsu; Kobayashi, Shunsuke; Ugawa, Yoshikazu; Tateno, Hiroyuki; Fujimori, Keiya

    2017-09-01

    The purpose of this study was to evaluate the effects of 3rd-generation (3G) cellular phone radiofrequency-electromagnetic wave (RF-EMW) exposure on fertilization and embryogenesis in mice. Oocytes and spermatozoa were exposed to 3G cellular phone RF-EMWs, 1.95 GHz wideband code division multiple access, at a specific absorption rate of 2 mW/g for 60 min, or to sham exposure. After RF-EMW exposure, in vitro fertilization and intracytoplasmic sperm injection were performed. Rates of fertilization, embryogenesis (8-cell embryo, blastocyst), and chromosome aberration were compared between the combined spermatozoa and oocyte groups: both exposed, both non-exposed, one exposed, and the other non-exposed. Rates of fertilization, embryogenesis, and blastocyst formation did not change significantly across the four groups. Considering that the degree of exposure in the present study was ≥100 times greater than daily exposure of human spermatozoa and even greater than daily exposure of oocytes, the present results indicate safety of RF-EMW exposure in humans. Bioelectromagnetics. 38:466-473, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  17. Sublexical spelling deficits in German 3rd graders with developmental language impairment: the effects of phonological-awareness training

    Directory of Open Access Journals (Sweden)

    Jürgen Cholewa

    2013-12-01

    Full Text Available Numerous treatment studies conducted with dyslexic children from divergent alphabetic systems support the assumption that phonological awareness and consequently alphabetic reading and spelling can be trained effectively in preschool and during the first two years of literacy acquisition. However, for older primary school children acquiring a transparent orthography, such as German, these training approaches are considered to be ineffective, because in these languages the comparably simple relations between phonemes and graphemes can be understood even by most dyslexic children up to the end of the second grade. In this paper evidence is provided that this optimistic prediction should not be generalized to all subgroups of dyslexic/dysgraphic children in German. The 26 dyslexic German 3rd graders from specialized schools for children with developmental speech and language impairments who participated in a treatment study showed severe difficulties when they were asked to write simple pseudowords based on dictation or to segment these pseudowords phonemically. Even after 10 hours of training with one of two different treatment approaches the performance of these children in writing and analyzing pseudowords only improved to a limited extent and remained far below an age appropriate level. Consequences for the development of more efficacious methods to help improve the alphabetic spelling skills of German children with particularly severe and persistent orthographic and phonological difficulties are discussed.

  18. Strategies for bird conservation: The Partners in Flight planning process; Proceedings of the 3rd Partners in Flight Workshop; 1995 October 1-5; Cape May, NJ

    Science.gov (United States)

    Rick Bonney; David N. Pashley; Robert J. Cooper; Larry Niles

    2000-01-01

    This volume represents a compilation of papers presented at the 3rd International Partners in Flight Workshop held October 1-5, 1995, at the Grand Hotel in Cape May, NJ. The title of the workshop was "Partners in Flight Conservation Plan: Building Consensus for Action." Manuscripts have been available on-line at the Cornell Laboratory of Ornithology web site...

  19. for video describing a prestigious Government of Canada prize which the Canadian team in ALPHA will be awarded on February 3rd

    CERN Multimedia

    2013-01-01

    Footage for video describing a prestigious Government of Canada prize which the Canadian team in ALPHA will be awarded on February 3rd 2014. On the video: -Mic-Michael Hayden (Simon Fraser Univ.) -Walter Hardy (Univ. of British Columbia) -Andrea Capra (York Univ.)hael Hayden (Simon Fraser Univ.)

  20. Traditional Chinese Medicine Playing a More Important Role in the World's Complementary Medicine Research——Minutes of the 3rd International Congress on Complementary Medicine Research

    Institute of Scientific and Technical Information of China (English)

    FEI Yu-tong; LIU Jian-ping

    2008-01-01

    @@ Outline The 3rd Intemational Congress on Complementary Medicine Research(ICCMR 2008)was held on 29-31 March,2008 in Sydney,Australia.More than 550 participants from over 30 countries in the diverse field of complementary medicine attended this great event.

  1. A Comparison of Low IQ Scores from the Reynolds Intellectual Assessment Scales and the Wechsler Adult Intelligence Scale--Third Edition

    Science.gov (United States)

    Umphress, Thomas B.

    2008-01-01

    Twenty people with suspected intellectual disability took the Reynolds Intellectual Assessment Scales (RIAS; C. R. Reynolds & R. W. Kamphaus, 1998) and the Wechsler Adult Intelligence Scale--3rd Edition (WAIS-III; D. Wechsler, 1997) to see if the 2 IQ tests produced comparable results. A t test showed that the RIAS Composite Intelligence Index…

  2. Genome editing in cardiovascular diseases.

    Science.gov (United States)

    Strong, Alanna; Musunuru, Kiran

    2017-01-01

    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  3. High variability among Emergency Departments in 3rd-generation cephalosporins and fluoroquinolones use for community-acquired pneumonia.

    Science.gov (United States)

    Batard, Eric; Lecadet, Nathalie; Goffinet, Nicolas; Hardouin, Jean-Benoit; Lepelletier, Didier; Potel, Gilles; Montassier, Emmanuel

    2015-12-01

    Fluoroquinolones and 3rd-generation cephalosporins that are prescribed for pneumonia may be avoided and replaced by a penicillin in some cases. We aimed to determine if the proportion of patients treated for pneumonia with a cephalosporin, a fluoroquinolone or both varies among Emergency Departments (EDs), and to estimate the proportion of avoidable prescriptions. This was a retrospective study of patients treated for pneumonia in eight French EDs, and subsequently hospitalized in non-ICU wards. Third-generation cephalosporins or respiratory fluoroquinolones were presumed unavoidable if they met both criteria: (1) age ≥65 years or comorbid condition; and (2) allergy or intolerance to penicillin, or failure of penicillin, or previous treatment with penicillin, or for fluoroquinolones only, suspected legionellosis. We included 832 patients. Thirty-four percent (95 % CI, 31-38 %) of patients were treated with a cephalosporin, a respiratory fluoroquinolone or both (range among EDs 19-44 %). Four EDs were independent risk factors for prescription of a cephalosporin, a fluoroquinolone or both [adjusted OR, 2.27 (1.64-3.15)], as were immune compromise [aOR 2.54 (1.56-4.14)], antibacterial therapy started before arrival in the ED [aOR 3.32 (2.30-4.81)], REA-ICU class III or IV [aOR 1.93 (1.15-3.23)], PSI class V [aOR 1.49 (1.00-2.20)], fluid resuscitation [aOR 3.98 (2.49-6.43)] and non-invasive ventilation in the ED [aOR, 7.18 (1.7-50.1)]. Treatment with a cephalosporin, a fluoroquinolone or both was avoidable in 67 % (62-73 %) of patients. Cephalosporins and fluoroquinolones use in pneumonia is highly variable among EDs. The majority of these prescriptions are avoidable. Antibiotic stewardship programs should be implemented to restrict their use in EDs.

  4. Effectiveness and safety of vaginal misoprostol for induction of labour in unfavourable cervix in 3rd trimester.

    Science.gov (United States)

    Abbasi, Nasreen; Danish, Nargis; Shakoor, Farah; Parveen, Zahida; Bilal, Syed Ahmad

    2008-01-01

    The use of prostaglandin preparations with or without oxytocin infusion, is widely recognized and accepted as a standard method of induction of labour. It has been shown to reduce induction time and the risk of failed induction. The objective of this quasi-experimental observational study was to determine the effectiveness and safety of Misoprostol administered vaginally for induction of labour to achieve vaginal delivery. This study was conducted from October 2004 to October 2007. The study was conducted at Shaheena Jamil Teaching Hospital, Frontier Medical College, Abbottabad and Women and Children Hospital Abbottabad. A total of 6299 obstetric patients were received for delivery and 946 patients had to undergo induction of labour. Primary outcome measures were to address clinical effectiveness (delivery within 24-hours) and safety (uterine hyper-stimulation, Caesarean Section and serious Maternal Morbidity). Secondary outcome measures included neonatal outcome. Out of 946 cases, successful vaginal deliveries were achieved in 843 (89.1%) cases. Time interval between induction and delivery was 4-24 hours. Oxytocin was required in 107 (12%) patients. Caesarean Section had to be done in 103 (10.8%) cases. The indications for Caesarean Section were foetal distress in 42 (40%), occipito-posterior position in 8 (7.7%), abruptioplacentae 2 (1.9%), cord around the neck 9 (7%), uterine hyperstimulation 6 (5.8%) and failure to progress in 20 (19%) cases. Admission to NICU was 28 (3.3%) and Neonatal deaths were 5 (0.5%). Postpartum Haemorrhage (PPH) was observed in 22 (2.3%) patients. There was no case of rupture uterus. Vaginal Misoprostol appears to be safe and effective for cervical ripening in 3rd Trimester. It helps vaginal delivery within 24 hours, does not increase incidence of Caesarean Section and has no adverse effect on foetal outcome. It could also be used in circumstances where extensive monitoring techniques are not available though close observation and

  5. AN INTERNAL MEDICINE SIMULATED PRACTICAL EXAM FOR ASSESSMENT OF CLINICAL COMPETENCY IN 3RD YEAR MEDICAL STUDENTS

    Science.gov (United States)

    Bodamer, Cheryl; Feldman, Moshe; Kushinka, Jeffrey; Brock, Ellen; Dow, Alan; Evans, Jessica A.; Bearman, Gonzalo

    2015-01-01

    Introduction Achieving standardized assessment of medical student competency in patient care is a challenge. Simulation may provide unique contributions to overall assessment. We developed an Internal Medicine Standardized Simulation Based Examination (SSBE) for the 3rd year clerkship to assess students’ medical knowledge, diagnostic skills, and clinical management skills. We assessed convergent and test-criterion validity by comparing the relationship of SSBE scores with USMLE Step 2 clinical knowledge, shelf exam, eQuiz, OSCE, ward evaluation scores, and overall clerkship grades. We hypothesize that use of the SSBE will allow for a more reliable assessment of these competencies and add value to existing assessments. Methods A prospective study design was used. The SSBE consisted of a computer based photo quiz and cases on high fidelity simulators. Performance on the SSBE was compared to standardized examinations, clinical evaluations, and overall clerkship grades. Students completed an evaluation of the experience. Results Two hundred seven students completed the SSBE, with a mean score of 76.69 (SD 7.78). SSBE performance was positively related to other assessments of medical knowledge (eQuiz scores (r(203) =.33, p< .01), shelf exam scores (r(158) =.53, p< .01), and clinical performance (ward scores) (r(163) =.31, p<.01) but not to OSCE scores. There was a positive relationship to final class grades (r(163) = .45, p<.01), shelf exam (r (158) =.52, p<.01) and Step 2 clinical knowledge scores (r(76) =.54, p<.01). The majority (93%) of students agreed that it was a fair exam. Conclusion Our results provide validity evidence for the SSBE as an additional assessment tool that uses a novel approach for evaluating competency in patient care at the clerkship level. PMID:26650701

  6. Organizational Support for the 3rd Summer Institute on Complex Plasmas, July 30 – August 8, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, Jose L. [Seton Hall University

    2012-07-01

    This grant provided partial funds for American graduate students to attend the 3rd Graduate Summer Institute on Complex Plasmas, which was held from July 30 to August 8, 2012 at Seton Hall University in South Orange, New Jersey. The Graduate Summer Institute is a topical series of instructional workshops held bi-annually on the emerging field of complex plasmas that is jointly organized through a collaboration between American and German-European Union plasmas researchers. This specialized program brings together many of the world's leading researchers in the specialized area of complex plasmas, who freely provide instructional lectures and tutorials on the most recent research and discoveries done in this branch of plasma science. The partial funds provided by this grant helped support the travel and accommodation expenses of the participating American students and tutorial instructors. Partial funds further supported the travel and accommodation of three renown American plasma researchers that provided educational tutorials to the thirty-eight participating students from the United States, Europe, and Asia. The organized program afforded a unique opportunity for the participating American graduate students to learn about and engage more deeply in an area of plasma science that is not studied in any of the graduate educational curriculums provided by universities in the United States of America. The educational experience offered by this program provided the necessary knowledge needed by future American plasma researchers to keep the national plasma research effort on the cutting-edge and keep the national plasma community as a global leader.

  7. Differences between 2nd and 3rd generation seric parathormone determination methods on mortality in haemodialysis patients.

    Science.gov (United States)

    Rodríguez-Osorio, Laura; de la Piedra, Concepción; Rubert, Mercedes; Martín-Fernández, Marta; González Casaus, María Luisa; Gracia-Iguacel, Carolina; Egido, Jesús; Villa-Bellosta, Ricardo; González Parra, Emilio

    Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). To evaluate the differences in mortality of dialysis patients between both assays to measure PTH, as well as the possible prognostic role of the PTHbio/iPTH ratio. 145 haemodialysis patients were included with 2-year monitoring including baseline laboratory test and annually thereafter. 21 patients died in the first year and 28 in the second. No correlation was found between PTH, PTHbio and PTHbio/iPTH ratio with mortality. Both PTH have a perfect correlation between them and correlate similarly with other molecules of the mineral metabolism. The extreme baseline values of PTH are those of higher mortality. In survival by iPTH intervals (according to guidelines and COSMOS study), a J curve is observed. When iPTH increases, the ratio decreases, possibly when increasing fragments no. 1-84. There is no greater prognostic approximation on mortality with PTHbio than PTHi. There was also no difference in mortality when progression ratio PTHbio/PTHi was analysed. We didn't find any advantages to using bioPTH vs. PTHi as a marker of mortality. BioPTH limits of normality must be reevaluated because its relationship with iPTH is not consistent. Not knowing these limits affects its prognostic value. Copyright © 2017 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  8. Site-Directed Genome Knockout in Chicken Cell Line and Embryos Can Use CRISPR/Cas Gene Editing Technology

    Directory of Open Access Journals (Sweden)

    Qisheng Zuo

    2016-06-01

    Full Text Available The present study established an efficient genome editing approach for the construction of stable transgenic cell lines of the domestic chicken (Gallus gallus domesticus. Our objectives were to facilitate the breeding of high-yield, high-quality chicken strains, and to investigate gene function in chicken stem cells. Three guide RNA (gRNAs were designed to knockout the C2EIP gene, and knockout efficiency was evaluated in DF-1 chicken fibroblasts and chicken ESCs using the luciferase single-strand annealing (SSA recombination assay, T7 endonuclease I (T7EI assay, and TA clone sequencing. In addition, the polyethylenimine-encapsulated Cas9/gRNA plasmid was injected into fresh fertilized eggs. At 4.5 d later, frozen sections of the embryos were prepared, and knockout efficiency was evaluated by the T7EI assay. SSA assay results showed that luciferase activity of the vector expressing gRNA-3 was double that of the control. Results of the T7EI assay and TA clone sequencing indicated that Cas9/gRNA vector-mediated gene knockdown efficiency was approximately 27% in both DF-1 cells and ESCs. The CRISPR/Cas9 vector was also expressed in chicken embryos, resulting in gene knockdown in three of the 20 embryos (gene knockdown efficiency 15%. Taken together, our results indicate that the CRISPR/Cas9 system can mediate stable gene knockdown at the cell and embryo levels in domestic chickens.

  9. Applications of genome editing in insects

    Science.gov (United States)

    Insect genome editing was first reported 1991 in Drosophila melanogaster but the technology used was not portable to other species. Not until the recent development of facile, engineered DNA endonuclease systems has gene editing become widely available to insect scientists. Most applications in inse...

  10. CRISPR/Cas基因组靶向编辑技术综述%Review about CRISPR/Cas system as a new targeted genome editing tech-nology

    Institute of Scientific and Technical Information of China (English)

    贾良杰

    2014-01-01

    CRISPR (clustered, regularly interspaced, short, palindromic repeats)/Cas (CRISPR-associated) systems are a unique prokaryotic defense against foreign genetic elements. It also be considered as a targeted genome editing tool in molecular biology research. Because of its simplicity, high success rate and high efficiency in genome targeting, Cas system became the best genome targeting tools compared with ZFNs (Zinc-finger nucleases) and TALENs (Transcrip-tion activator-like effector nucleases). According to the recent researches, Cas system could be used as an efficient system for site-specific transcriptional repression or activation. Additionally, a specific Cas9 protein has been observed to target an RNA substrate, suggesting that Cas9 may have the same ability as RNAi technology to be programmed to target RNA as well. Overall, the targeted genome editing technology via CRISPR/Cas system has been Widely promot-ed and applied in many field such as the research on gene functions, the the disease model of gene knock-out animal construction and the gene therapy. So it will have significant impact on future advancements in genome engineering.%Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated(Cas)是细菌特有的一种获得性免疫系统,研究人员将其改造成为靶向基因组编辑的工具,由于操作简单、成功率高且效率高,成为了靶向基因组编辑工具中的佼佼者。同时CRISPR/Cas系统也被改造作为一种极为有效的位点特异性的转录抑制/激活的工具而在研究工作中广泛应用,不仅如此,具有靶向细胞转录过程中产生的RNA底物的利用前景,从而起到与RNAi技术相类似的效果。 CRISPR-Cas技术已经在基因功能研究、动物模型建立、基因治疗等领域得到广泛的推广和应用,有力地推动了相关领域的研究进展。

  11. ICOM2012: 3rd International Conference on the Physics of Optical Materials and Devices (Belgrade, Serbia, 2-6 September 2012)

    Science.gov (United States)

    Dramićanin, Miroslav D.; Antić, Željka; Viana, Bruno

    2013-11-01

    The 3rd International Conference on the Physics of Optical Materials and Devices (ICOM2012) was held in Belgrade (Serbia) from 2 to 6 September 2012 (figure 1). The conference was organized by the Vinča Institute of Nuclear Sciences, University of Belgrade (Serbia) and the Laboratoire de Chimie de la Matière Condensée de Paris (France), and supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia and Optical Society of America. ICOM2012 was a follow-up to the two previous, successful ICOM conferences held in Herceg Novi in 2006 and 2009. The conference aimed at providing a forum for scientists in optical materials to debate on: • Luminescent materials and nanomaterials • Hybrid optical materials (organic/inorganic) • Characterization techniques of optical materials • Luminescence mechanisms and energy transfers • Theory and modeling of optical processes • Ultrafast-laser processing of materials • Optical sensors • Medical imaging • Advanced optical materials in photovoltaics and biophotonics • Photothermal and photoacoustic spectroscopy and phenomena The conference stressed the value of a fundamental scientific understanding of optical materials. A particular accent was put on wide band-gap materials in crystalline, glass and nanocrystalline forms. The applications mainly involved lasers, scintillators and phosphors. Rare earth and transition metal ions introduced as dopants in various hosts were considered, and their impact on the optical properties were detailed in several presentations. This volume contains selected contributions of speakers and participants of the ICOM2012 conference. The conference provided a unique opportunity for about 200 scientists from 32 countries to discuss recent progress in the field of optical materials. During the three and half days, 21 invited talks and 52 contributed lectures were given, with a special event in memory of our dear colleague Professor Dr Tsoltan

  12. Baseline Hepatitis B Virus DNA Level is a Promising Factor for Predicting the 3 rd Month Virological Response to Entecavir Therapy: A Study of Strict Defined Hepatitis B virus Induced Cirrhosis

    Directory of Open Access Journals (Sweden)

    Yang Xu

    2015-01-01

    Conclusions: Baseline HBV DNA, HBeAg negativity, and ALT were independent factors contributing to virological response at the 3 rd month. Further, multiple regression showed that HBV DNA level was the only parameter predicting full virological response as early as the 3 rd month, in this cirrhosis cohort.

  13. A Low Distortion 3rd-Order Continuous-Time Delta-Sigma Modulator for a Worldwide Digital TV-Receiver

    Science.gov (United States)

    Obata, Koji; Matsukawa, Kazuo; Mitani, Yosuke; Takayama, Masao; Tokunaga, Yusuke; Sakiyama, Shiro; Dosho, Shiro

    This paper presents a low distortion 3rd-order continuous-time delta-sigma modulator for a worldwide digital TV-receiver whose peak SNDR is 69.8dB and SNR is 70.2dB under 1V power supply. To enhance SNDR performance, the mechanisms to occur harmonic distortions at feedback current-steering DAC and flash ADC have been analyzed. A low power tuning system using RC-relaxation oscillator has been developed in order to achieve high yield against PVT variations. A 3rd-order modulator with modified single opamp resonator contributes to cost reduction by realizing a very compact circuit. Reduction schemes of the distortions enabled the modulator to achieve FOM of 0.18pJ/conv-step.

  14. Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

    OpenAIRE

    Kerns, Suzanne; Puspitasari, Ajeng; Hendricks, Karin; Pierson, Andria; Fizur, Phil; Comtois, Katherine A.; Green, Amy E; Trott, Elise M.; Willging, Cathleen E.; Fernandez, Maria E.; Woolf, Nicholas H.; Liang, Shuting Lily; Heredia, Natalia I.; Kegler, Michelle; Risendal, Betsy

    2016-01-01

    Table of contents Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective ...

  15. Medical students’ skills in image interpretation before and after training: A comparison between 3rd-year and 6th-year students from two different medical curricula

    Energy Technology Data Exchange (ETDEWEB)

    Sendra-Portero, Francisco, E-mail: sendra@uma.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain); Torales-Chaparro, Oscar E., E-mail: oetjft@terra.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain); Ruiz-Gómez, Miguel J., E-mail: mjrg@uma.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain)

    2012-12-15

    The purpose of this study was to assess student's performance in the interpretation of images before and after training in radiology, by comparing two groups, 6th-year and 3rd-year students, from two different medical curricula. Students participated in an anonymous evaluation consisting of the interpretation of 12 radiological images accompanied with the salient history and clinical data by answering 60 open-ended questions about technique, anatomy, semiology, and clinics. The number of correct, incorrect and blank responses of each group was used to compare pre- and post-training results. Unpaired two-sample t-test was used to evaluate differences between groups. A significant increase in correct responses was found in both groups after training. The comparison between both groups did not show differences for incorrect answers of the whole test and correct answers about anatomy in the pre-training evaluation. The percentage of correct answers to the median question improved from 15.5% to 53.3% for 6th-year students and from 8.3% to 41.1% for 3rd-year students. The post-training evaluation showed a significant increase of correct answers of 6th-year students with respect to 3rd-year students (mean ± standard deviation 53.6 ± 31.3% and 38.7 ± 29.9% respectively), mainly due to differences in technical and clinical questions. This study provides objective and quantitative evidence of pre- and post-training student skills in image interpretation. The similarities found in the previous level of knowledge and skills of both groups emphasizes the suitable change of the first-time training in radiology, from the 6th to the 3rd year course in medical curricula.

  16. A Learning Organization Born in the Crucible of Combat: The 3rd Infantry Brigade, 2nd Division, in World War I

    Science.gov (United States)

    2016-06-10

    division was expected to fight and were, figuratively speaking , students under Lejeune’s tutelage. This is important because the new commanders...Organization. The skillful practice of personal mastery, challenging mental models, creating a shared vision, fostering team learning and developing...organization. In the end, the 3rd Infantry Brigade demonstrated personal mastery of warfighting skills , challenged the status quo of their doctrine

  17. Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

    OpenAIRE

    Kerns, Suzanne; Puspitasari, Ajeng; Hendricks, Karin; Pierson, Andria; Fizur, Phil; Comtois, Katherine A.; Green, Amy E.; Trott, Elise M.; Willging, Cathleen E.; Fernandez, Maria E.; Woolf, Nicholas H.; Liang, Shuting Lily; Heredia, Natalia I.; Kegler, Michelle; Risendal, Betsy

    2016-01-01

    Table of contents Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective ...

  18. Food Micro 2010, 22th International ICFMH Symposium, “ Microbial Behaviour in the Food Chain ” 30th August – 3rd September 2010, Copenhagen, Denmark

    DEFF Research Database (Denmark)

    2012-01-01

    This Special Issue of International Journal of Food Microbiology contains a selection of papers presented at Food Micro 2010, the 22th Symposium of the International Committee on Food Microbiology and Hygiene (ICFMH). Food Micro 2010 was held on 30th August to 3rd September 2010 in Copenhagen, De......, Denmark and organized in collaboration between the Danish Centre for Advanced Food Studies (LMC) and Lund University in Sweden....

  19. The construction of the CMS electromagnetic calorimeter: delivery of the 3rd and 4th endcap "Dees" and Ring Flanges to CERN

    CERN Multimedia

    2006-01-01

    Delivery of the 3rd and 4th Dees and Ring Flanges of the CMS-ECAL endcaps to CERN. The pictures show also an endcap crystal with its VPT (Vacuum PhotoTriode), the aluminium blackplates of the endcap Dees and four mock supercrystals (5x5 crystals) attached in their position on the backplate, along with 138 positional spacers. Finally, endcap assembly in the CMS construction hall in Cessy (neighbouring France) is also shown.

  20. “The 3 rd International Conference on Islamic Banking and Finance: Risk Management, Regulation and Supervision” Jakarta, Indonesia, 22-24 February 2010.

    OpenAIRE

    Only, Report

    2010-01-01

    The conference “3rd International Conference on Islamic Banking and Finance: Risk Management, Regulation and Supervision” was jointly organized by IRTI and Center of Islamic Economics and Business (PEBS) University of Indonesia and cohosted by Bank Indonesia. It started with a welcoming ceremony and dinner on 22nd of February. The ceremony was addressed by H. E. Sri Mulyani Indrawarti, then Minister of Finance, Republic of Indonesia (currently Executive Director at World Bank). In her speech ...

  1. The temperature field and heat transfer in the porthole of the Space Shuttle - Outer surface under the 3rd kind nonlinear boundary condition

    Science.gov (United States)

    Tan, Heping; Yu, Qizheng; Zhang, Jizhou

    In this paper, the transient combined heat transfer in the silicon glass porthole of Space Shuttle is studied by control volume method, ray tracing method and spectral band model. The temperature field in the silicon glass and heat flux entering the space cabin are given under the 3rd kind nonlinear boundary condition. The computational results show, if the radiation in the silicon glass is omitted, the errors for temperature fields are not too evident, but for heat flux are quite large.

  2. Proceedings of the 3rd International Symposium on Material Chemistry in Nuclear Environment (MATERIAL CHEMISTRY '02, MC '02); March 13-15, 2002, Tsukuba

    OpenAIRE

    MC'02企画委員会

    2003-01-01

    The volume contains all presented papers during the the 3rd International Symposium on Material Chemistry in Nuclear Environment: MATERIAL CHEMISTRY '02 (MC'02), held March 13-15, 2002. The purpose of this symposium is to provide an international forum for the discussion of recent progress in the field of materials chemistry in nuclear environments. This symposium intends to build on the success of the previous symposiums held in Tsukuba in 1992 and 1996. The topics discussed in the symposium...

  3. Symposium on High-Speed Aerodynamics and Structures (3rd) Held at San Diego, California on March 25-27, 1958. Volume 1.

    Science.gov (United States)

    1958-03-01

    3RD Symposium Cooý " HIGH-SPEED AERODYNAMICS AND STRUCTURES SAN DIEGO., CALIF DTIC Fft EELECTE ti"tSAUG0 419 F 1ThIU~~4 do ume hat be~ aapm p ubi...waves as shown in Fig. 19. 1-0 £ - 45 rnsee -. 5 rnsec t, t ime Fig. 19. The 5-Millisecond Buildup, Finite Rise Time Wave Form 155 The distance at which a

  4. Testing post-editing guidelines

    DEFF Research Database (Denmark)

    Flanagan, Marian; Christensen, Tina Paulsen

    2014-01-01

    There is a growing interest in machine translation (MT) and post-editing (PE). MT has been around for decades, but the use of the technology has grown significantly in the language industry in recent years, while PE is still a relatively new task. Consequently, there are currently no standard PE ...

  5. 基因组靶向编辑技术:CRISPR/Cas9研究进展%Genome editing technology: CRISPR/Cas9

    Institute of Scientific and Technical Information of China (English)

    原慧萍; 杨泽

    2015-01-01

    Efficiently targeted genome editing technology is required for functional elucidation of gene,animal models,etiology searching,and gene therapy.CRISPR/Cas9 is a kind of adaptive immune defenses in bacteria and archaea for foreign nucleic acids and has been proven to be a versatile tool for RNA-guided site-specific DNA cleavage in a large range of cell types and whole organisms.Compared with previous tools,CRISPR/Cas9 is a more convenient and efficient gene-targeting technology which has been used extensively in all fields.Here we describe the CRISPR/Cas9 characteristics,principle,methodology,and application,and then discuss current advantages/weaknesses and potential solutions in details.%基因组靶向编辑技术是研究基因功能、模式动物构建、疾病病因学以及基因治疗领域面临的关键问题.最近兴起的CRISPR/Cas9是细菌和古细菌在长期演化过程中形成的一种适应性免疫防御,对抗入侵的病毒以及外源DNA.利用RNA引导的Cas9核酸酶可在多种细胞及动物上实现对特定的基因组位点的切割和修饰.CRISPR/Cas9系统以其操作简单经济和快速高效等优点在各个领域广泛应用.本文简要阐述了CRISPR/Cas系统的发现、基本结构、原理及其应用,并讨论了其可能存在的问题及应对策略.

  6. CIFLog: the 3rd generation logging software based on Java-NetBeans%基于Java-NetBeans的第三代测井软件CIFLog

    Institute of Scientific and Technical Information of China (English)

    李宁; 王才志; 刘英明; 李伟忠; 夏守姬; 原野

    2013-01-01

    To follow direction of well-logging technology development, get rid of dependence on foreign well-logging software, improve capability of independent innovation, and enchance core competitiveness, CIFLog, the 3rd generation well-logging software which has independent intellectual property rights, has been successfully developed by PetroChina supported by the major national oil and gas project. Based on advanced Java-NetBeans programming technology, CIFLog adopts three-layer structure, and it can run under three major operating systems, i. e. Windows, Linux and Unix. Combine with well-logging evaluation of open-holes and cased holes, CIFLog offers the interpretation methods of complex reservoir including volcanic, carbonate, low-resistivity clastic rocks and flooded zones, and it is the first well-logging software that can be successfully applied to processing and interpretation of all domestically produced high-end imaging logging equipment in China. The successful development of the software not only breaks technical barriers of foreign software, and also fill gaps in relevant fields, meanwhile, it greatly enhances well logging technology and research and development of large-scale software in China.%为了紧跟测井技术的发展方向,摆脱对国外测井软件的依赖,提高自主创新能力,开发具有自主知识产权的测井处理解释软件,提升核心竞争力,中国石油天然气集团公司依托国家油气重大专项,成功研发了第三代测井软件CIFLog.CIFLog基于先进的Java-NetBeans编程技术,采用数据层、支持层和应用层3层框架结构,可以同时运行在Windows、Linux和Unix操作系统下.CI-FLog还将全系列裸眼测井评价与套后测井评价集成为一体,提供了火山岩、碳酸盐岩、低阻碎屑岩和水淹层等复杂储层的处理解释方法,并在国内首家对全部国产高端成像测井装备处理解释提供支持.该软件的成功研发不仅打破了国外软件技术封锁的

  7. Beginning XML, 5th Edition

    CERN Document Server

    Fawcett, Joe; Quin, Liam R E

    2012-01-01

    A complete update covering the many advances to the XML language The XML language has become the standard for writing documents on the Internet and is constantly improving and evolving. This new edition covers all the many new XML-based technologies that have appeared since the previous edition four years ago, providing you with an up-to-date introductory guide and reference. Packed with real-world code examples, best practices, and in-depth coverage of the most important and relevant topics, this authoritative resource explores both the advantages and disadvantages of XML and addresses the mo

  8. [Genome editing of industrial microorganism].

    Science.gov (United States)

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  9. 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning

    CERN Document Server

    Prieta, Fernando; Mascio, Tania; Gennari, Rosella; Rodríguez, Javier; Vittorini, Pierpaolo

    2016-01-01

    The 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning held in Seville (Spain) is host by the University of Seville from 1st to 3rd June, 2016. The 6th edition of this conference expands the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions or web-based ones. It intends to bring together researchers and developers from industry, the education field and the academic world to report on the latest scientific research, technical advances and methodologies.

  10. Network-based Lesson Plans Online Editing Technology Management System Design and Implementation%基于在线编辑技术的网络教案管理系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    敬国东

    2013-01-01

    网络教案的编辑与管理一直是网络教学过程重要工作环节,也是制约网络教学资源建设的一个瓶颈环节。本文结合网络教案管理的实际需求,分析了网络教案管理系统的功能结构、数据结构及关键程序编制技术,实现了一个基于在线编辑技术的网络教案管理系统。该系统使得教师可能在线编辑与管理网络教案,提高了网络教案开发效率。%Network lesson plans editing and network teaching process management has been an important aspect of our work, but also restrict the construction of a network teaching resource bottlenecks. In this paper, the actual needs of the network management lesson plans, lesson plans analyzed network management system functions, data structure and key programming technology to achieve a network-based lesson plans online editing technology management system. The system allows teachers to edit and manage the network may be online lesson plans, lesson plans developed to improve the efifciency of the network.

  11. 第三空间中语言的自我协商式进化%The Self-negotiated Language Evolution in the 3rd Space

    Institute of Scientific and Technical Information of China (English)

    丁晓蔚

    2015-01-01

    The 3rd Space in the age of globalization is a zone for native language and target language to encounter,coordinate and integrate with each other.Language users create linguistic variations through individual self-negotiation,a driving force of lan-guage evolution.Language communities select and spread the linguistic variations through collective self-negotiation,a maintain-ing force of language evolution.Therefore,the language evolution in the 3rd space is a self-negotiated process.In addition,the 3rd space enables native language and target language to enjoy equal status and power,and enables language users to advance their lin-guistic competence in both directions,in balance,and in dimensions of context,development,content and medium.%全球化时代的第三空间是本族语和目的语接触、冲突、协调、融合的地带,语言使用者通过个体自我协商创造语言变体,产生语言进化的驱动力;通过群体自我协商选择和传播语言变体,维持语言进化的惯性.因此,第三空间的语言进化是自我协商式的语言演化过程.第三空间的时代特点赋予本族语和目的语渐趋平等的地位和权力,使语言使用者的语言能力在语境、发展、内容和介质四个维度均呈现双向平衡发展的趋势.

  12. The 3rd CARISMA international conference on medium and high temperature proton exchange membrane fuel cells: Three approaches to better platinum catalysts at biannual conference

    DEFF Research Database (Denmark)

    Jensen, Jens Oluf; Cleemann, Lars Nilausen; Li, Qingfeng

    2013-01-01

    The 3rd CARISMA International Conference was held at the Axelborg venue in Copenhagen, Denmark, from September 3-5, 2012. The CARISMA conference series was specifically devoted to challenges in the development and testing of fuel cell materials and membrane electrode assemblies (MEAs) for proton...... exchange membrane fuel cells (PEMFCs) to be operated at intermediate and high temperatures. The conference series was initiated by the European CARISMA Coordination Action for Research on Intermediate and High Temperature Specialized Membrane Electrode Assemblies. The 2012 event in Copenhagen had around...

  13. 21st Century Strategies for Protected Areas in East Asia--Briefs of the 3rd Conference on Conservative Land in East Asia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zurong

    2001-01-01

    @@ The author had the opportunity to attend the 3rd Conference on the Conservative Land in East Asia in Seoul, Korea in September 1999, whose theme was " 21st Century Strategies for Protected Areas in East Asia". As the majority of protected areas in China is located in mountain areas,since the government announced prohibition of any commercial wood cutting, all mountains have become sort of protected areas in a certain degree. The following is a brief introduction on the major issues discussed at the conference.

  14. Highly efficient source for frequency-entangled photon pairs generated in a 3rd order periodically poled MgO-doped stoichiometric LiTaO3 crystal

    CERN Document Server

    Kim, Heonoh; Lee, Sang Min; Moon, Han Seb

    2015-01-01

    We present a highly efficient source for discrete frequency-entangled photon pairs based on spontaneous parametric down-conversion using 3rd order type-0 quasi-phase matching in a periodically poled MgO-doped stoichiometric LiTaO3 crystal pumped by a 355.66 nm laser. Correlated two-photon states were generated with automatic conservation of energy and momentum in two given spatial modes. These states have a wide spectral range, even under small variations in crystal temperature, which consequently results in higher discreteness. Frequency entanglement was confirmed by measuring two-photon quantum interference fringes without any spectral filtering.

  15. Efficacy studies of Vectobac 12as and Teknar HP-D larvicides against 3rd-instar Ochlerotatus taeniorhynchus and Culex quinquefasciatus in small plot field studies.

    Science.gov (United States)

    Floore, T G; Petersen, J L; Shaffer, K R

    2004-12-01

    Efficacy studies were conducted with VectoBac 12AS and Teknar HP-D larvicides against 3rd-instar Ochlerotatus taeniorhynchus and Culex quinquefasciatus in small field test plots. The products were obtained off the shelf from distributors and had different lot numbers. They were evaluated over a 2-year period in spring 2002 and 2003. Application rates were 0.29, 0.58, and 1.10 liter/ha and evaluations were made 24 and 48 h after treatment. Both products performed well in these studies, with VectoBac 12AS being more effective at the 0.29 liter/ha rate.

  16. High resolution three-dimensional (256 to the 3rd) spatio-temporal measurements of the conserved scalar field in turbulent shear flows

    Science.gov (United States)

    Dahm, Werner J. A.; Buch, Kenneth A.

    Results from highly resolved three-dimensional spatio-temporal measurements of the conserved scalar field zeta(x,t) in a turbulent shear flow. Each of these experiments consists of 256 to the 3rd individual point measurements of the local instantaneous conserved scalar value in the flow. The spatial and temporal resolution of these measurements reach beyond the local Kolmogorov scale and resolve the local strain-limited molecular diffusion scale in the flow. The results clearly show molecular mixing occurring in thin strained laminar diffusion layers in a turbulent flow.

  17. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference & APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    Science.gov (United States)

    2016-02-01

    The iMEC 2015 is the second International Manufacturing Engineering Conference organized by the Faculty of Manufacturing, Universiti Malaysia Pahang (UMP), held from 12-14th November 2015 in Kuala Lumpur, Malaysia, with a theme "Materials, Manufacturing and Systems for Tomorrow". For the first time, iMEC is organized together with 3rd Asia- Pacific Conference on Manufacturing System (APCOMS 2015) which owned by Fakulti Teknologi Industri, Institut Teknologi Bandung (ITB), Indonesia. This is an extended collaboration between UMP and ITB to intensify knowledge sharing and experiences between higher learning institutions. This conference (iMEC & APCOMS 2015) is a platform for knowledge exchange and the growth of ideas, particularly in manufacturing engineering. The conference aims to bring researchers, academics, scientists, students, engineers and practitioners from around the world together to present their latest findings, ideas, developments and applications related to manufacturing engineering and other related research areas. With rapid advancements in manufacturing engineering, iMEC is an appropriate medium for the associated community to keep pace with the changes. In 2015, the conference theme is “Materials, Manufacturing and Systems for Tomorrow” which reflects the acceleration of knowledge and technology in global manufacturing. The papers in these proceedings are examples of the work presented at the conference. They represent the tip of the iceberg, as the conference attracted over 200 abstracts from Malaysia, Indonesia, Japan, United Kingdom, Australia, India, Bangladesh, South Africa, Turkey and Morocco and 151 full papers were accepted in these proceedings. The conference was run in four parallel sessions with 160 presenters sharing their latest finding in the areas of manufacturing process, systems, advanced materials and automation. The first keynote presentation was given by Prof. B. S. Murthy (IIT, Madras) on "Nanomaterials with Exceptional

  18. 4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

  19. Interservice/Industry Training Equipment Conference and Exhibition (3rd) , Orlando, Florida, 30 November-2 December 1981

    Science.gov (United States)

    1981-01-01

    used to manually matAix ). This writer, however, believes that construct the digraph from the modified matrix, although Tatsuoka’s contention is valid and...11CLA and San Jose State University. Andy R. Werback, Engineering Snecialist Applied Technology Division of ITEK Mr. Werback has been the lead engineer

  20. Genome editing systems in novel therapies.

    Science.gov (United States)

    Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui

    2016-01-01

    Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in human cells, however, had prevented its clinical application until the recent advancements in designer endonuclease technologies. The significantly improved genome editing efficiencies aided by ZFN, TALEN, and CRISPR systems provide unprecedented opportunities not only for biomedical research, but also for developing novel therapies. Applications based on these genome editing tools to disrupt deleterious genes, correct genetic mutations, deliver functional transgenes more effectively or even modify the epigenetic landscape are being actively investigated for gene and cell therapy purposes. Encouraging results have been obtained in limited clinical trials in the past two years. While most of the applications are still in proof-of-principle or preclinical development stages, it is anticipated that the coming years will see increasing clinical success in novel therapies based on the modern genome editing technologies. It should be noted that critical issues still remain before the technologies can be translated into more reliable therapies. These key issues include off-target evaluation, establishing appropriate preclinical models and improving the currently low efficiency of homology-based precise gene replacement. In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation.

  1. Edit wars in Wikipedia

    CERN Document Server

    Sumi, Róbert; Rung, András; Kornai, András; Kertész, János

    2011-01-01

    We present a new, efficient method for automatically detecting severe conflicts `edit wars' in Wikipedia and evaluate this method on six different language WPs. We discuss how the number of edits, reverts, the length of discussions, the burstiness of edits and reverts deviate in such pages from those following the general workflow, and argue that earlier work has significantly over-estimated the contentiousness of the Wikipedia editing process.

  2. Sustainability in Energy and Buildings : Proceedings of the 3rd International Conference in Sustainability in Energy and Buildings

    CERN Document Server

    Namaane, Aziz; Howlett, Robert; Jain, Lakhmi

    2012-01-01

    Welcome to the proceedings of the Third International Conference on Sustainability in Energy and Buildings, SEB’11, held in Marseilles in France, organised by the Laboratoire des Sciences del'Information et des Systèmes (LSIS) in Marseille, France in partnership with KES International.   SEB'11 formed a welcome opportunity for researchers in subjects related to sustainability, renewable energy technology, and applications in the built environment to mix with other scientists, industrialists and stakeholders in the field.   The conference featured presentations on a range of renewable energy and sustainability related topics. In addition the conference explored two innovative themes: - the application of intelligent sensing, control, optimisation and modelling techniques to sustainability and - the technology of sustainable buildings.  These two themes combine synergetically to address issues relating to The Intelligent Building.   SEB’11 attracted a significant number of submissions from around the w...

  3. Conference Proceedings on Applied Computational Electromagnetics (3rd) Held in Monterey, California on 24-26 March 1987

    Science.gov (United States)

    1987-03-01

    Model Comparison for a Dihedral Corner Reflector " J.L. FathA.J. Terzuoli, E.G. Zelnio Air Force Institute of Technology "Quant m-Mechanical Techniques... radar cross section has been computed for a particular scatterer associated with a matrix A using a moment method code, we call the computation of the... radar cross section of a slightly perturbed scatterer a perturbed problem of A. ff the original problem has n unknowns, and the perturbed problem is

  4. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...... for editing nucleic acids and a cell comprising a stably integrated endonuclease....

  5. Manipulating the Biosynthesis of Bioactive Compound Alkaloids for Next-Generation Metabolic Engineering in Opium Poppy Using CRISPR-Cas 9 Genome Editing Technology.

    Science.gov (United States)

    Alagoz, Yagiz; Gurkok, Tugba; Zhang, Baohong; Unver, Turgay

    2016-08-03

    Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated9 (Cas9) endonuclease system is a powerful RNA-guided genome editing tool. CRISPR/Cas9 has been well studied in model plant species for targeted genome editing. However, few studies have been reported on plant species without whole genome sequence information. Currently, no study has been performed to manipulate metabolic pathways using CRISPR/Cas9. In this study, the type II CRISPR/SpCas9 system was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in opium poppy (Papaver somniferum L.), a gene which regulates the biosythesis of benzylisoquinoline alkaloids (BIAs). For sgRNA transcription, viral-based TRV and synthetic binary plasmids were designed and delivered into plant cells with a Cas9 encoding-synthetic vector by Agrobacterium-mediated transformation. InDels formed by CRISPR/Cas9 were detected by sequence analysis. Our results showed that the biosynthesis of BIAs (e.g. morphine, thebaine) was significantly reduced in the transgenic plants suggesting that 4'OMT2 was efficiently knocked-out by our CRISPR-Cas9 genome editing approach. In addition, a novel uncharacterized alkaloid was observed only in CRISPR/Cas9 edited plants. Thus, the applicabilitiy of the CRISPR/Cas9 system was demonstrated for the first time for medicinal aromatic plants by sgRNAs transcribed from both synthetic and viral vectors to regulate BIA metabolism and biosynthesis.

  6. Book of abstracts: 3rd International Conference on Smart Energy Systems and 4th Generation District Heating

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    of the European 2020 goals as well as future sustainable energy solutions in general. The Smart Energy System approach was defined in 2011 in the CEESA project. The project addressed Danish scenarios with a particular focus on renewable energy in the transport system in a context with limited access to bioenergy....... The Smart Energy System concept is essential for 100% renewable energy systems to harvest storage synergies and exploit low-value heat sources. The most effective and least-cost solutions are to be found when the electricity sector is combined with the heating and cooling sectors and/or the transport sector....... Moreover, the combination of electricity and gas infrastructures may play an important role in the design of future renewable energy systems. In its research on low-temperature district heating, the Strategic Research Centre for 4th Generation District Heating Technologies and Systems enhances...

  7. Genome edited animals: Learning from GM crops?

    Science.gov (United States)

    Bruce, Ann

    2017-06-01

    Genome editing of livestock is poised to become commercial reality, yet questions remain as to appropriate regulation, potential impact on the industry sector and public acceptability of products. This paper looks at how genome editing of livestock has attempted to learn some of the lessons from commercialisation of GM crops, and takes a systemic approach to explore some of the complexity and ambiguity in incorporating genome edited animals in a food production system. Current applications of genome editing are considered, viewed from the perspective of past technological applications. The question of what is genome editing, and can it be considered natural is examined. The implications of regulation on development of different sectors of livestock production systems are studied, with a particular focus on the veterinary sector. From an EU perspective, regulation of genome edited animals, although not necessarily the same as for GM crops, is advocated from a number of different perspectives. This paper aims to open up new avenues of research on genome edited animals, extending from the current primary focus on science and regulation, to engage with a wider-range of food system actors.

  8. X-ray holographic microscopy with zone plates applied to biological samples in the water window using 3rd harmonic radiation from the free-electron laser FLASH.

    Science.gov (United States)

    Gorniak, T; Heine, R; Mancuso, A P; Staier, F; Christophis, C; Pettitt, M E; Sakdinawat, A; Treusch, R; Guerassimova, N; Feldhaus, J; Gutt, C; Grübel, G; Eisebitt, S; Beyer, A; Gölzhäuser, A; Weckert, E; Grunze, M; Vartanyants, I A; Rosenhahn, A

    2011-06-06

    The imaging of hydrated biological samples - especially in the energy window of 284-540 eV, where water does not obscure the signal of soft organic matter and biologically relevant elements - is of tremendous interest for life sciences. Free-electron lasers can provide highly intense and coherent pulses, which allow single pulse imaging to overcome resolution limits set by radiation damage. One current challenge is to match both the desired energy and the intensity of the light source. We present the first images of dehydrated biological material acquired with 3rd harmonic radiation from FLASH by digital in-line zone plate holography as one step towards the vision of imaging hydrated biological material with photons in the water window. We also demonstrate the first application of ultrathin molecular sheets as suitable substrates for future free-electron laser experiments with biological samples in the form of a rat fibroblast cell and marine biofouling bacteria Cobetia marina.

  9. Final report for the 3rd Ex-Vessel Neutron Dosimetry Installations and Evaluations for Kori Unit 1 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai (and others)

    2008-03-15

    This report describes a neutron fluence assessment performed for the Kori Unit 1 pressure vessel belt line region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the belt line region of the pressure vessel. After Cycle 23 of reactor operation, 3rd Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 1 to provide continuous monitoring of the belt line region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 24.

  10. Lateral seismic prediction of 3rd member sand reservoir in Shahejie formation in Southern Bohai oil field and the prediction result

    Energy Technology Data Exchange (ETDEWEB)

    Wengong, H.; Hongming, C.; Jinlian, L. (Geophysical Exploration Corporation, Hengli Oil Management Bureau, Niuzhuang, (Dongying City))

    1992-01-01

    Major reservoir in Southern Bohar Oil Field is the 3rd member turbidite sand in the Shahejie formation. The lateral seismic prediction involves the following interpretation jobs: comprehensive analysis of average velocity, synthetic seismogram and VSP data in the area; recognition of reservoir reflection characters in high-resolution seismic section which goes through well; lateral reservoir prediction using the reflection characters; plotting the structural map and isopach map of the reservoir; and offering favourable exploratory well site after reasonable reservoir evaluation that uses relevant materials, such as dynamic and static data of hydrocarbon. In this paper, using the technique, the authors have interpreted 17 sand bodies covering 38 km[sup 2] totally, and offered 25 exploration and development well sites. 8 wells have been completed, of which 7 wells produce industrial oil flow. The predicted horizons coincide with the drilled ones very well. Very good exploration effect has been received satisfactorily.

  11. Variations in the geomagnetic field strength in the 5th 3rd centuries BC in the eastern Mediterranean (according to narrowly dated ceramics)

    Science.gov (United States)

    Nachasova, I. E.; Burakov, K. S.; Il'Ina, T. A.

    2008-06-01

    The magnetization of ceramics from the eastern Mediterranean dated within a short period (mostly shorter than ±20 years) has been studied, which made it possible to specify the geomagnetic field variations on the time interval 5th 3rd centuries BC. The 11-year time series of the geomagnetic field strength values has been constructed. The field strength changes have been considered, which indicated that the centennial variation with a characteristic time of ˜130 years (according to the obtained data) is observed on this time interval as well as during the last two millennia. The ceramic material from the Mayskaya Gora archeological site (Taman), the preparation succession of which was established based on the shape of pottery but the problem of absolute dating was not solved, has been dated.

  12. An estimate of the minting method of three silver coins of the 3rd century B.C. through their microstructural study

    Energy Technology Data Exchange (ETDEWEB)

    Pistofidis, N.; Vourlias, G. [Department of Physics, Aristotle University of Thessaloniki, Thessaloniki (Greece); Dilo, T. [Department of Physics, FNSc, University of Tirana, Tirana (Albania); Civici, N. [Department of Spectroscopy, Institute of Nuclear Physics, Tirana (Albania); Gjongecaj, Sh. [Department of Antiquity, Institute of Archaeology, Tirana (Albania); Skolianos, S. [Physical Metallurgy Laboratory, Department of mechanical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki (Greece); Polychroniadis, E.K., E-mail: polychr@auth.g [Department of Physics, Aristotle University of Thessaloniki, Thessaloniki (Greece)

    2010-05-01

    The microstructure of three silver coins of the 3rd century B.C. from the Illyrian King Monounios and the ancient Greek cities of Dyrrachion and Corcyra, belonging to the Kreshpan hoard, was determined with X-ray diffraction and transmission electron microscopy in order to investigate their minting method. It is deduced that the coins are characterized by a large number of structural defects, mainly dislocations, twins and microtwins, which in some cases were bent. These crystal defects are common in each of the coins examined. This information allowed the formulation of a possible minting method. Since twins in FCC metals are formed with thermal treatment, and mechanical twinning is rather improbable, it seems that the coins were initially hot-worked. Bent twins indicate that working continued during cooling. Especially for the Corcyra coin it was deduced that it was treated at higher temperature or its cooling rate was lower.

  13. Passive magnetic bearing in the 3rd generation miniature axial flow pump-the valvo pump 2.

    Science.gov (United States)

    Okamoto, Eiji; Ishida, Yuya; Yano, Tetsuya; Mitamura, Yoshinori

    2015-06-01

    The new miniature axial flow pump (valvo pump 2) that is installed at the base of the ascending aorta consists of a six-phase stator, an impeller in which four neodymium magnets are incorporated, and passive magnetic bearings that suspend the impeller for axial levitation. The impeller is sustained by hydrodynamic force between the blade tip of the impeller and the inner housing of the stator. The passive magnetic bearing consists of a ring neodymium magnet and a columnar neodymium magnet. The ring neodymium magnet is set in the stationary side and the columnar neodymium magnet is incorporated in the impeller shaft. Both neodymium magnets are coaxially mounted, and the anterior and posterior passive magnetic bearings suspend the impeller by repulsion force against the hydrodynamic force that acts to move the impeller in the inflow port direction. The passive magnetic bearing was evaluated by a tensile test, and the levitation force of 8.5 N and stiffness of 2.45 N/mm was obtained. Performance of the axial flow pump was evaluated by an in vitro experiment. The passive magnetic bearing showed sufficient levitation capacity to suspend the impeller in an axial direction. In conclusion, the passive magnetic bearing is promising to be one of levitation technology for the third-generation axial flow blood pump.

  14. Application Progress of CRISPR/Cas9 System for Gene Editing in Tumor Research

    OpenAIRE

    Liu, Chao; Li, Zhiwei; Zhang, Yanqiao

    2015-01-01

    TCRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-associated nuclease 9) gene editing system is a new type of gene editing technology developed based on the immune mechanism of archaea resisting the invasion of exogenous nucleic acid. Compared with traditional gene editing system, CRISPR/Cas9 system is more efficient, easier operating, and less cytotoxic. Currently, CRISPR/Cas9 gene editing technology has been applied to many aspects of cancer research, including r...

  15. Genome editing with engineered nucleases in plants.

    Science.gov (United States)

    Osakabe, Yuriko; Osakabe, Keishi

    2015-03-01

    Numerous examples of successful 'genome editing' now exist. Genome editing uses engineered nucleases as powerful tools to target specific DNA sequences to edit genes precisely in the genomes of both model and crop plants, as well as a variety of other organisms. The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as genome editing tools, in the form of designed ZF nucleases (ZFNs). More recently, transcription activator-like effector nucleases (TALENs), as well as the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, which utilizes RNA-DNA interactions, have proved useful. A key step in genome editing is the generation of a double-stranded DNA break that is specific to the target gene. This is achieved by custom-designed endonucleases, which enable site-directed mutagenesis via a non-homologous end-joining (NHEJ) repair pathway and/or gene targeting via homologous recombination (HR) to occur efficiently at specific sites in the genome. This review provides an overview of recent advances in genome editing technologies in plants, and discusses how these can provide insights into current plant molecular biology research and molecular breeding technology.

  16. LMFBR (LIQUID METAL FAST BREEDER REACTOR) READTION RATE AND DOSIMETRY 3RD QUARTERLY PROGRESS REPORT DECEMBER 1971 JANUARY FEBRUARY 1972

    Energy Technology Data Exchange (ETDEWEB)

    MCELROY WN

    1972-03-01

    This report was compiled at the Hanford Engineering Development Laboratory operated by Westinghouse Hanford Company, a subsidiary of Westinghouse Electric Corporation, for the United States Atomic Energy Commission, Division of Reactor Development and Technology, under Contract No. AT (45-1) 2170. It describes technical progress made in the Interlaboratory LMFBR Reaction Rate Program during the reporting period. The Interlaboratory LMFBR Reaction Rate (ILRR) program has been established by USAEC/RDT to develop a capability to accurately measure neutron-induced reaction rates for LMFBR fuels and materials development programs. The initial goal for the principal fission reactions, {sup 235}U, {sup 238}U, and {sup 239}Pu, is an accuracy to within {+-}5 at the 95% confidence level. Accurate measurement of other fission and non-fission reactions will be required, but to a lesser accuracy, between {+-}5 to 10% at the 95% confidence level. A secondary program objective is improvement in knowledge of the nuclear parameters involved in fuels and materials dosimetry measurements of neutron flux, spectra, fluence, and burnup. These accuracy goals for the ILRR program are severe; measurements of fast-neutron-induced reaction rates have not been rapidly moving toward this level of precision. Using a number of techniques in well established neutron environments of current interest for fast reactor development and critically evaluating the results will help establish existing levels of accuracy and indicate the scale of effort required for improvement. To accomplish the objectives of this program, reliable and documented experimental values of reaction rates and ratios will be determined for various well established and permanent neutron fields. The Coupled Fast Reactivity Measurement Facility (CFRMF) at Aerojet Nuclear Company (ANC) is the first neutron field being studied because of the similarity of its spectrum to that of a fast reactor and the range and reproducibility of

  17. Ethical and regulatory aspects of genome editing.

    Science.gov (United States)

    Kohn, Donald B; Porteus, Matthew H; Scharenberg, Andrew M

    2016-05-26

    Gene editing is a rapidly developing area of biotechnology in which the nucleotide sequence of the genome of living cells is precisely changed. The use of genome-editing technologies to modify various types of blood cells, including hematopoietic stem cells, has emerged as an important field of therapeutic development for hematopoietic disease. Although these technologies offer the potential for generation of transformative therapies for patients suffering from myriad disorders of hematopoiesis, their application for therapeutic modification of primary human cells is still in its infancy. Consequently, development of ethical and regulatory frameworks that ensure their safe and effective use is an increasingly important consideration. Here, we review a number of issues that have the potential to impact the clinical implementation of genome-editing technologies, and suggest paths forward for resolving them such that new therapies can be safely and rapidly translated to the clinic. © 2016 by The American Society of Hematology.

  18. Effects of Deep Water Source-Sink Terms in 3rd generation Wave Model SWAN using different wind data in Black Sea

    Science.gov (United States)

    Kirezci, Cagil; Ozyurt Tarakcioglu, Gulizar

    2016-04-01

    Coastal development in Black Sea has increased in recent years. Therefore, careful monitoring of the storms and verification of numerical tools with reliable data has become important. Previous studies by Kirezci and Ozyurt (2015) investigated extreme events in Black Sea using different wind datasets (NCEP's CFSR and ECMWF's operational datasets) and different numerical tools (SWAN and Wavewatch III). These studies showed that significant effect to results is caused by the deep water source-sink terms (wave growth by wind, deep water dissipation of wave energy (whitecapping) and deep water non-linear wave-wave interactions). According to Timmermans(2015), uncertainty about wind forcing and the process of nonlinear wave-wave interactions are found to be dominant in numerical wave modelling. Therefore, in this study deep water source and sink term solution approaches of 3rd generation numerical tool (SWAN model) are tested, validated and compared using the selected extreme storms in Black Sea. 45 different storms and storm like events observed in Black Sea between years 1994-1999 are selected to use in the models. The storm selection depends on the instrumental wave data (significant wave heights, mean wave period and mean wave direction) obtained in NATO-TU Waves project by the deep water buoy measurements at Hopa, Sinop, Gelendzhik, and wind data (mean and peak wind speeds, storm durations) of the regarding events. 2 different wave growth by wind with the corresponding deep water dissipation terms and 3 different wave -wave interaction terms of SWAN model are used in this study. Wave growth by wind consist of two parts, linear growth which is explained by Cavaleri and Malanotte-Rizzoli(1981),and dominant exponential growth. There are two methods in SWAN model for exponential growth of wave, first one by Snyder et al. (1981), rescaled in terms of friction velocity by Komen et. al (1984) which is derived using driving wind speed at 10m elevation with related drag

  19. A Prospective Treatment Option for Lysosomal Storage Diseases: CRISPR/Cas9 Gene Editing Technology for Mutation Correction in Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Chloe L. Christensen

    2017-02-01

    Full Text Available Ease of design, relatively low cost and a multitude of gene-altering capabilities have all led to the adoption of the sophisticated and yet simple gene editing system: clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9. The CRISPR/Cas9 system holds promise for the correction of deleterious mutations by taking advantage of the homology directed repair pathway and by supplying a correction template to the affected patient’s cells. Currently, this technique is being applied in vitro in human-induced pluripotent stem cells (iPSCs to correct a variety of severe genetic diseases, but has not as of yet been used in iPSCs derived from patients affected with a lysosomal storage disease (LSD. If adopted into clinical practice, corrected iPSCs derived from cells that originate from the patient themselves could be used for therapeutic amelioration of LSD symptoms without the risks associated with allogeneic stem cell transplantation. CRISPR/Cas9 editing in a patient’s cells would overcome the costly, lifelong process associated with currently available treatment methods, including enzyme replacement and substrate reduction therapies. In this review, the overall utility of the CRISPR/Cas9 gene editing technique for treatment of genetic diseases, the potential for the treatment of LSDs and methods currently employed to increase the efficiency of this re-engineered biological system will be discussed.

  20. Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.

    Science.gov (United States)

    Ascierto, Paolo A; Atkins, Michael; Bifulco, Carlo; Botti, Gerardo; Cochran, Alistair; Davies, Michael; Demaria, Sandra; Dummer, Reinhard; Ferrone, Soldano; Formenti, Silvia; Gajewski, Thomas F; Garbe, Claus; Khleif, Samir; Kiessling, Rolf; Lo, Roger; Lorigan, Paul; Arthur, Grant Mc; Masucci, Giuseppe; Melero, Ignacio; Mihm, Martin; Palmieri, Giuseppe; Parmiani, Giorgio; Puzanov, Igor; Romero, Pedro; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Taube, Janis; Tomei, Sara; Zarour, Hassane M; Testori, Alessandro; Wang, Ena; Galon, Jérôme; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena

    2015-11-30

    The fourth "Melanoma Bridge Meeting" took place in Naples, December 3-6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers. Until recently systemic therapy for metastatic melanoma patients was ineffective, but recent advances in tumor biology and immunology have led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS). New therapies, such as mitogen-activated protein kinase (MAPK) pathway inhibitors as well as other signaling pathway inhibitors, are being tested in patients with metastatic melanoma either as monotherapy or in combination, and all have yielded promising results. These include inhibitors of receptor tyrosine kinases (BRAF, MEK, and VEGFR), the phosphatidylinositol 3 kinase (PI3K) pathway [PI3K, AKT, mammalian target of rapamycin (mTOR)], activators of apoptotic pathway, and the cell cycle inhibitors (CDK4/6). Various locoregional interventions including radiotherapy and surgery are still valid approaches in treatment of advanced melanoma that can be integrated with novel therapies. Intrinsic, adaptive and acquired resistance occur with targeted therapy such as BRAF inhibitors, where most responses are short-lived. Given that the reactivation of the MAPK pathway through several distinct mechanisms is responsible for the majority of acquired resistance, it is logical to combine BRAF inhibitors with inhibitors of targets downstream in the MAPK pathway. For example, combination of BRAF/MEK inhibitors (e.g., dabrafenib/trametinib) have been demonstrated to improve survival compared to monotherapy. Application of novel technologies such sequencing have proven useful as a tool for identification of MAPK pathway-alternative resistance mechanism and designing other combinatorial therapies such as those between BRAF and AKT inhibitors. Improved

  1. Fuel Cell Handbook, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  2. Current and future editing reagent delivery systems for plant genome editing.

    Science.gov (United States)

    Ran, Yidong; Liang, Zhen; Gao, Caixia

    2017-05-01

    Many genome editing tools have been developed and new ones are anticipated; some have been extensively applied in plant genetics, biotechnology and breeding, especially the CRISPR/Cas9 system. These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems. Finally, we will reflect on possible future directions.

  3. Designed nucleases for targeted genome editing.

    Science.gov (United States)

    Lee, Junwon; Chung, Jae-Hee; Kim, Ho Min; Kim, Dong-Wook; Kim, Hyongbum

    2016-02-01

    Targeted genome-editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine and biotechnology. Using this genome-modifying technology, researchers can precisely and efficiently insert, remove or change specific sequences in various cultured cells, micro-organisms, animals and plants. This genome editing is based on the generation of double-strand breaks (DSBs), repair of which modifies the genome through nonhomologous end-joining (NHEJ) or homology-directed repair (HDR). In addition, designed nickase-induced generation of single-strand breaks can also lead to precise genome editing through HDR, albeit at relatively lower efficiencies than that induced by nucleases. Three kinds of designed nucleases have been used for targeted DSB formation: zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system. A growing number of researchers are using genome-editing technologies, which have become more accessible and affordable since the discovery and adaptation of CRISPR-Cas9. Here, the repair mechanism and outcomes of DSBs are reviewed and the three types of designed nucleases are discussed with the hope that such understanding will facilitate applications to genome editing.

  4. Assisted reproductive technologies in Portuguese law--commentary to the Judgment no. 101/2009, of March the 3rd of the Portuguese Constitutional Court.

    Science.gov (United States)

    Raposo, Vera Lúcia; Vale e Reis, Rafael

    2009-01-01

    Recently the Portuguese Constitutional Court was asked to analyze the constitutionality of the law on assisted reproduction, Law nr 32/2006. The request was presented by a conservative group, arguing, basically, that the law disregarded the juridical protection due to the embryo and to the participants in reproductive techniques. The main critics pointed out were related with the legitimacy of using reproductive techniques, the absence of a maximum age for beneficiaries, the authorization of embryo experimentation, the decision of not criminalizing every contract of surrogate motherhood, among some other critics. However, the Court concluded that none of the pointed norms went against Constitutional rules and principles.

  5. Proceedings of the International Conference on Algebraic Methodology and Software Technology (3rd) Held in The Netherlands on June 21 - 25, 1993

    Science.gov (United States)

    1993-06-25

    Automatica Facultad de Ciencias Matemiticas - Universidad Complutense 28040 Madrid , Spain Introduction We compare in this paper graphic and algebraic...Abstract Prolog Compiler Julio Garda-Martfn Juan Jo*6 Moreno-Navarro Universidad Politdcnica de Madrid " 1 Motivation and related work In the last years...Chicago, USA Juan Quemada University of Madrid , E Ralph Wachter Office of Naval Research, Arlington, USA Local Committee: Herman Balsters, Han Biumer

  6. Proceedings of the Annual National Conference on Ada (Trademark) Technology (3rd) Held at Prarie View, Texas on 20-21 March 1985.

    Science.gov (United States)

    1985-01-01

    design phase of the DSDA reslts in the Sdeselopment 04 three staoes ot design refinement as showr i,, Fiqure ’. Each stage y,..,, yFRF0 oo°F- builds... DSDA ) 1F UNIV AND TS FUNCTIONAL SFWR PRTEST DSG AR PRCEDURES DECRPIODEVE sSOFTR ADA FDL% TEST L STEPWISE PLAN REFINEMENT IF TEST TEEN A.L. SO1W FTWAR

  7. Developing new levels of edit

    Energy Technology Data Exchange (ETDEWEB)

    Prono, J.; DeLanoy, M.; Deupree, R.; Skiby, J.; Thompson, B.

    1998-07-01

    In 1985, the writing and editing group at Los Alamos National Laboratory established four levels of edit for technical reports. When a survey in 1994 showed that both authors and editors felt the levels were not meeting author needs, the authors set about revising them. Their goals were to simplify the editing process, focus editing on improving technical clarity, and ensure that value was added in editing. This paper describes the revision process and product -- three author-based levels of edit.

  8. DNA-free genome editing methods for targeted crop improvement.

    Science.gov (United States)

    Kanchiswamy, Chidananda Nagamangala

    2016-07-01

    Evolution of the next-generation clustered, regularly interspaced, short palindromic repeat/Cas9 (CRISPR/Cas9) genome editing tools, ribonucleoprotein (RNA)-guided endonuclease (RGEN) RNPs, is paving the way for developing DNA-free genetically edited crop plants. In this review, I discuss the various methods of RGEN RNPs tool delivery into plant cells and their limitations to adopt this technology to numerous crop plants. Furthermore, focus is given on the importance of developing DNA-free genome edited crop plants, including perennial crop plants. The possible regulation on the DNA-free, next-generation genome-edited crop plants is also highlighted.

  9. A Kinesthetic Learning Approach to Earth Science for 3rd and 4th Grade Students on the Pajarito Plateau, Los Alamos, NM

    Science.gov (United States)

    Wershow, H. N.; Green, M.; Stocker, A.; Staires, D.

    2010-12-01

    Current efforts towards Earth Science literacy in New Mexico are guided by the New Mexico Science Benchmarks [1]. We are geoscience professionals in Los Alamos, NM who believe there is an important role for non-traditional educators utilizing innovative teaching methods. We propose to further Earth Science literacy for local 3rd and 4th grade students using a kinesthetic learning approach, with the goal of fostering an interactive relationship between the students and their geologic environment. We will be working in partnership with the Pajarito Environmental Education Center (PEEC), which teaches the natural heritage of the Pajarito Plateau to 3rd and 4th grade students from the surrounding area, as well as the Family YMCA’s Adventure Programs Director. The Pajarito Plateau provides a remarkable geologic classroom because minimal structural features complicate the stratigraphy and dramatic volcanic and erosional processes are plainly on display and easily accessible. Our methodology consists of two approaches. First, we will build an interpretive display of the local geology at PEEC that will highlight prominent rock formations and geologic processes seen on a daily basis. It will include a simplified stratigraphic section with field specimens and a map linked to each specimen’s location to encourage further exploration. Second, we will develop and implement a kinesthetic curriculum for an exploratory field class. Active engagement with geologic phenomena will take place in many forms, such as a scavenger hunt for precipitated crystals in the vesicles of basalt flows and a search for progressively smaller rhyodacite clasts scattered along an actively eroding canyon. We believe students will be more receptive to origin explanations when they possess a piece of the story. Students will be provided with field books to make drawings of geologic features. This will encourage independent assessment of phenomena and introduce the skill of scientific observation. We

  10. The Safety of Artemisinin Derivatives for the Treatment of Malaria in the 2nd or 3rd Trimester of Pregnancy: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    van Eijk, Anna Maria; Sevene, Esperanca; Dellicour, Stephanie; Weiss, Noel S.; Emerson, Scott; Steketee, Richard; ter Kuile, Feiko O.; Stergachis, Andy

    2016-01-01

    Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy. However, several organ systems are still under development later in pregnancy. We conducted a systematic review and meta-analysis of the occurrence of adverse pregnancy outcomes among women treated with artemisinins monotherapy or as artemisinin-based combination therapy during the 2nd or 3rd trimesters relative to pregnant women who received non-artemisinin antimalarials or none at all. Pooled odds ratio (POR) were calculated using Mantel-Haenszel fixed effects model with a 0.5 continuity correction for zero events. Eligible studies were identified through Medline, Embase, and the Malaria in Pregnancy Consortium Library. Twenty studies (11 cohort studies and 9 randomized controlled trials) contributed to the analysis, with 3,707 women receiving an artemisinin, 1,951 a non-artemisinin antimalarial, and 13,714 no antimalarial. The PORs (95% confidence interval (CI)) for stillbirth, fetal loss, and congenital anomalies when comparing artemisinin versus quinine were 0.49 (95% CI 0.24–0.97, I2 = 0%, 3 studies); 0.58 (95% CI 0.31–1.16, I2 = 0%, 6 studies); and 1.00 (95% CI 0.27–3.75, I2 = 0%, 3 studies), respectively. The PORs comparing artemisinin users to pregnant women who received no antimalarial were 1.13 (95% CI 0.77–1.66, I2 = 86.7%, 3 studies); 1.10 (95% CI 0.79–1.54, I2 = 0%, 4 studies); and 0.79 (95% CI 0.37–1.67, I2 = 0%, 3 studies) for miscarriage, stillbirth and congenital anomalies respectively. Treatment with artemisinin in 2nd and 3rd trimester was not associated with increased risks of congenital malformations or miscarriage and may be was associated with a reduced risk of stillbirths compared to quinine. This study updates the reviews

  11. 3rd International Algebra Conference

    CERN Document Server

    Fong, Yuen; Zelmanov, Efim

    2003-01-01

    This volume contains one invited lecture which was presented by the 1994 Fields Medal­ ist Professor E. Zelmanov and twelve other papers which were presented at the Third International Conference on Algebra and Their Related Topics at Chang Jung Christian University, Tainan, Republic of China, during the period June 26-July 1, 200l. All papers in this volume have been refereed by an international referee board and we would like to express our deepest thanks to all the referees who were so helpful and punctual in submitting their reports. Thanks are also due to the Promotion and Research Center of National Science Council of Republic of China and the Chang Jung Christian University for their generous financial support of this conference. The spirit of this conference is a continuation of the last two International Tainan­ Moscow Algebra Workshop on Algebras and Their Related Topics which were held in the mid-90's of the last century. The purpose of this very conference was to give a clear picture of the rece...

  12. 3rd International EXAFS Conference

    CERN Document Server

    Hedman, Britt; Penner-Hahn, James

    1984-01-01

    This volume contains the Proceedings of the Third International EXAFS Conference, hosted by Stanford University and the Stanford Synchrotron Radiation Laboratory on July 16-20, 1984. The meeting, co-chaired by Professors Arthur Bienenstock and Keith Hodgson, was attended by over 200 scientists representing a wide range of scientific disciplines. The format of the meeting consisted of 51 invited presenta­ tions and four days of poster sessions. This Proceedings is a compilation of 139 contributions from both invited speakers and authors of contributed posters. The last ten years has seen the rapid maturation of x-ray absorption spectrosco­ pyas a scientific discipline. The vitality of the field is reflected in the diver­ sity of applications found in the Proceedings. Recent work continues to probe the limits of x-ray spectroscopy, with proven techniques being extended to, for examp­ le, very low or high energy studies, to very dilute systems, and to studies of surface structure. In fact, the title of the c...

  13. Digital Video Editing

    Science.gov (United States)

    McConnell, Terry

    2004-01-01

    Monica Adams, head librarian at Robinson Secondary in Fairfax country, Virginia, states that librarians should have the technical knowledge to support projects related to digital video editing. The process of digital video editing and the cables, storage issues and the computer system with software is described.

  14. Quality text editing

    Directory of Open Access Journals (Sweden)

    Gyöngyi Bujdosó

    2009-10-01

    Full Text Available Text editing is more than the knowledge of word processing techniques. Originally typographers, printers, text editors were the ones qualified to edit texts, which were well structured, legible, easily understandable, clear, and were able to emphasize the coreof the text. Time has changed, and nowadays everyone has access to computers as well as to text editing software and most users believe that having these tools is enough to edit texts. However, text editing requires more skills. Texts appearing either in printed or inelectronic form reveal that most of the users do not realize that they are not qualified to edit and publish their works. Analyzing the ‘text-products’ of the last decade a tendency can clearly be drawn. More and more documents appear, which instead of emphasizingthe subject matter, are lost in the maze of unstructured text slices. Without further thoughts different font types, colors, sizes, strange arrangements of objects, etc. are applied. We present examples with the most common typographic and text editing errors. Our aim is to call the attention to these mistakes and persuadeusers to spend time to educate themselves in text editing. They have to realize that a well-structured text is able to strengthen the effect on the reader, thus the original message will reach the target group.

  15. Test Review: Colarusso, R. P., & Hammill, D. D. (2003). "Motor-Free Visual Perception Test."(3rd ed.). Novata, CA: Academic Therapy Publications

    Science.gov (United States)

    McCane, Sara Jean

    2006-01-01

    The Motor-Free Visual Perception Test: Third edition (MVPT-3; Colarusso & Hammill, 2003) purports to measure overall visual perceptual ability. Task responses require no motor ability, eliminating the effect of motor performance on the overall visual perception score. The test authors suggested that this MVPT-3 characteristic allows for its…

  16. Learning string edit distance

    CERN Document Server

    Ristad, E S; Ristad, Eric Sven; Yianilos, Peter N.

    1996-01-01

    In many applications, it is necessary to determine the similarity of two strings. A widely-used notion of string similarity is the edit distance: the minimum number of insertions, deletions, and substitutions required to transform one string into the other. In this report, we provide a stochastic model for string edit distance. Our stochastic model allows us to learn a string edit distance function from a corpus of examples. We illustrate the utility of our approach by applying it to the difficult problem of learning the pronunciation of words in conversational speech. In this application, we learn a string edit distance with one fourth the error rate of the untrained Levenshtein distance. Our approach is applicable to any string classification problem that may be solved using a similarity function against a database of labeled prototypes. Keywords: string edit distance, Levenshtein distance, stochastic transduction, syntactic pattern recognition, prototype dictionary, spelling correction, string correction, ...

  17. Variants of Topology Editing Strategy in the Subsystem of Printed Circuit Boards Manufacturability Improvement

    OpenAIRE

    Roman Panchak; Konstantyn Kolesnyk; Marian Lobur

    2011-01-01

    This paper focuses on the variants of printed circuit boards topology editing strategies implemented in the subsystem of automatic printed circuit boards topology editing. Depending on the requirements for printed circuit board topology, a subsystem user can create variants of editing strategies in order to minimize the amount of the technologically justified places with a minimum clearance between the elements of the topology.

  18. Phonological awareness and general performance in reading: What’s the relation? A study with 2nd and 3rd year fundamental school students

    Directory of Open Access Journals (Sweden)

    Ana Paula Couceiro Figueira

    2017-01-01

    Full Text Available The objective of this study was to test the content and concurrent validity of Prolec-R (FIGUEIRA; LOPES, n.d., investigation version, exploring the relations as a proof of phonological awareness (phoneme synthesis, SICOLE-R evaluation (FIGUEIRA; LOBO; LOPES; JIMÉNEZ, n.d., investigation version. The theoretical background comprises the evaluation of cognitive processes involved in reading (JIMENEZ’S and CUETOS’S perspectives, in which the two tests employed assume too evaluate such processes, and are considered concurrent procedures. Both are destined to children from 6 to 12 years old. The methodology used, for exploration and accessibility, a sample containing children from the 2nd and 3rd year of elementary school, from the public and education systems in Coimbra and Beira Interior Norte. The results revealed the existence of a positive and significant relation between the reading of words, reading of pseudo words, grammatical structures, punctuation marks and sentence comprehension (PROLEC-R and the phoneme synthesis (SICOLE-R.

  19. Searching for new gamma-ray blazar candidates in the 3rd Palermo BAT Hard X-ray Catalog with WISE

    CERN Document Server

    Maselli, A; Cusumano, G; D'Abrusco, R; La Parola, V; Paggi, A; Segreto, A; Smith, Howard A; Tosti, G

    2013-01-01

    We searched for gamma-ray blazar candidates among the 382 unidentified hard X-ray sources of the 3rd Palermo BAT Catalog (3PBC) obtained from the analysis of 66 months of SWIFT-BAT survey data and listing 1586 sources. We adopted a recently developed association method based on the peculiar infrared colors which characterize the gamma-ray blazars included in the second catalog of active galactic nuclei detected by the Fermi Large Area Telescope (2LAC). We used this method exploiting the data of the all-sky survey performed by the Wide-Field Infrared Survey Explorer (WISE) to establish correspondences between unidentified 3PBC sources and WISE gamma-ray blazar candidates located within the BAT positional uncertainty region at 99% confidence level. We obtained a preliminary list of candidates for which we analysed all the available data in the SWIFT archive to complement the information in the literature and in the radio, infrared and optical catalogs with the information on their optical-UV and soft X-ray emis...

  20. The Impact of Comprehensive Agrarian Reform Program (CARP on FarmerBeneficiaries in the 3rd Congressional District of Iloilo, Philippines

    Directory of Open Access Journals (Sweden)

    Ronaldo F. Frufonga

    2016-02-01

    Full Text Available The study aims to assess the impact of the comprehensive agrarian reform program on farmer beneficiaries in the 3rd Congressional District of the province of Iloilo for the year 2014. The Network design was used as research design to obtain and provide useful information in judging decision alternatives involve in the impact of Comprehensive Agrarian Reform Program to the farmerbeneficiaries. The participants were the 386 farmer beneficiaries. Data were gathered using surveychecklist form and analyzed through frequency counts, percentages, mean and t-test of dependent/correlated means. The researcher observed ethical considerations in conducting the study. The results show that the comprehensive agrarian reform program has a positive impact on the lives of the farmer beneficiaries. It has contributed to higher income and led to reduced poverty incidence before and after the program. The beneficiaries tend to be better off in terms of wellbeing compared to before the implementation of the program. They have better access to sanitary toilet facilities and potable water, and have a propensity to have higher educational attainment. Support services became essential in enhancing food security and building infrastructures that uphold food production, enhance trade, and increase income of the household beneficiaries living in the rural community. Further, the household farmer beneficiaries have a propensity to boost the chances to reduce poverty.