WorldWideScience

Sample records for technologies 3rd edition

  1. Introducing ZBrush 3rd Edition

    CERN Document Server

    Keller, Eric

    2012-01-01

    Learn ZBrush inside and out with this updated new edition Get totally comfortable sculpting in a digital environment with the latest edition of this bestselling beginner's guide to ZBrush. Fully updated for the newest version of the software, ZBrush 4R3, this book dispels any fears you might have about the difficulty of using ZBrush and soon has you creating realistic, cartoon, and organic models with flair. Learn all the essentials, as you complete fun tutorials on painting, meshes, organic scripting, hard surface sculpting, lighting, rendering, and more. Introduces you to ZBrush, the sculpt

  2. Veterinary Microbiology, 3rd Edition

    Science.gov (United States)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  3. Building java programs (3rd edition)

    CERN Document Server

    Reges, Stuart

    2013-01-01

    Building Java Programs: A Back to Basics Approach, Third Edition, introduces novice programmers to basic constructs and common pitfalls by emphasizing the essentials of procedural programming, problem solving, and algorithmic reasoning. By using objects early to solve interesting problems and defining objects later in the course, Building Java Programs develops programming knowledge for a broad audience. NEW! This edition is available with MyProgrammingLab, an innovative online homework and assessment tool. Through the power of practice and immediate personalized feedback, MyProgrammingLab helps students fully grasp the logic, semantics, and syntax of programming. Note: If you are purchasing the standalone text or electronic version, MyProgrammingLab does not come automatically packaged with the text. To purchase MyProgrammingLab, please visit: myprogramminglab.com or you can purchase a package of the physical text + MyProgrammingLab by searching the Pearson Higher Education web site. MyProgrammi...

  4. Alaska Highway bibliography, 3rd edition

    DEFF Research Database (Denmark)

    Prange, Laurie

    Since the early 20th century various schemes were considered for the construction of roads, trails or railways 71 to link the Yukon, northern British Columbia and Alaska to the “outside.” These schemes were motivated by economic interests, including mining, lumber and tourism concerns. During the....... The impacts included an increased awareness of the world outside of the Yukon, imported ideas and technology, improved health care, highway transportation, telecommunications, and the development of more mining and tourist-related industries....

  5. TIES for Dummies 3rd Edition (Technology Identification, Evaluation, and Selection) Basic how to's to implement the TIES method

    Science.gov (United States)

    Kirby, Michelle R.

    2002-01-01

    The TIES method is a forecasting environment whereby the decision-maker has the ability to easily assess and trade-off the impact of various technologies without sophisticated and time-consuming mathematical formulations. TIES provides a methodical approach where technically feasible alternatives can be identified with accuracy and speed to reduce design cycle time, and subsequently, life cycle costs, and was achieved through the use of various probabilistic methods, such as Response Surface Methodology and Monte Carlo Simulations. Furthermore, structured and systematic techniques are utilized from other fields to identify possible concepts and evaluation criteria by which comparisons can be made. This objective is achieved by employing the use of Morphological Matrices and Multi-Attribute Decision Making techniques. Through the execution of each step, a family of design alternatives for a given set of customer requirements can be identified and assessed subjectively or objectively. This methodology allows for more information (knowledge) to be brought into the earlier phases of the design process and will have direct implications on the affordability of the system. The increased knowledge allows for optimum allocation of company resources and quantitative justification for program decisions. Finally, the TIES method provided novel results and quantitative justification to facilitate decision making in the early stages of design so as to produce affordable and quality products.

  6. 3rd International Conference on Robot Intelligence Technology and Applications

    CERN Document Server

    Yang, Weimin; Jo, Jun; Sincak, Peter; Myung, Hyun

    2015-01-01

    This book covers all aspects of robot intelligence from perception at sensor level and reasoning at cognitive level to behavior planning at execution level for each low level segment of the machine. It also presents the technologies for cognitive reasoning, social interaction with humans, behavior generation, ability to cooperate with other robots, ambience awareness, and an artificial genome that can be passed on to other robots. These technologies are to materialize cognitive intelligence, social intelligence, behavioral intelligence, collective intelligence, ambient intelligence and genetic intelligence. The book aims at serving researchers and practitioners with a timely dissemination of the recent progress on robot intelligence technology and its applications, based on a collection of papers presented at the 3rd International Conference on Robot Intelligence Technology and Applications (RiTA), held in Beijing, China, November 6 - 8, 2014. For better readability, this edition has the total 74 papers group...

  7. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    RADOSTITS, O.M., GAY, C.C., and DOUGLAS, C.B.. (2000): Mastitis in Goats In: Veterinary Medicine, A. Text book of the Diseases of Cattle, Sheep, Goats,. Pigs and Horses, Ninth Edition, Book Power. Publishers. 669- 670. SHEARER, J. K., and HARRIS, B. (1992): Mastitis in. Dairy Goats. Univ. of Flor. Ext. J. 37(4): 31-33.

  8. Pediatric Dentistry: A Clinical Approach, 3rd Edition

    DEFF Research Database (Denmark)

    Pediatric Dentistry: A Clinical Approach, Third Edition provides a uniquely clear, comprehensive, and clinical approach to the dental treatment of children and adolescents. •Offers systematic coverage of all clinical, scientific and social topics relating to pediatric dentistry •Thoroughly revised...

  9. The cogeneration and small power production manual. 3rd edition

    International Nuclear Information System (INIS)

    Spiewak, S.A.

    1990-01-01

    This book is divided into six sections covering regulations, environmental issues, engineering, contract, financing, and taxes. The edition adds a comprehensive 80-page chapter outlining how to prepare for electric power shortages, including details on rate structure, tariff negotiation, contract-based rates, partial requirement service, supplementary, backup, and interruptible rates, and retail sale of electric power. The engineering section covers optimum cogeneration system design, operational considerations, and energy efficiency. Combustion turbines, diesel engines, gas engines, rotary engines, steam turbines, and electric generators are covered in detail

  10. Business planning for scientists and engineers[3rd edition]; TOPICAL

    International Nuclear Information System (INIS)

    Servo, Jenny C.

    1999-01-01

    This combination text/workbook is intended for use by scientists or engineers actively engaged in developing a product or technology to commercial production. The 'how' of planning is a central theme with special emphasis on development of operational plans and strategic thinking

  11. 3rd International Conference on Computer & Communication Technologies

    CERN Document Server

    Bhateja, Vikrant; Raju, K; Janakiramaiah, B

    2017-01-01

    The book is a compilation of high-quality scientific papers presented at the 3rd International Conference on Computer & Communication Technologies (IC3T 2016). The individual papers address cutting-edge technologies and applications of soft computing, artificial intelligence and communication. In addition, a variety of further topics are discussed, which include data mining, machine intelligence, fuzzy computing, sensor networks, signal and image processing, human-computer interaction, web intelligence, etc. As such, it offers readers a valuable and unique resource.

  12. 3rd International Conference on Intelligent Technologies and Engineering Systems

    CERN Document Server

    2016-01-01

    This book includes the original, peer reviewed research from the 3rd International Conference on Intelligent Technologies and Engineering Systems (ICITES2014), held in December, 2014 at Cheng Shiu University in Kaohsiung, Taiwan. Topics covered include: Automation and robotics, fiber optics and laser technologies, network and communication systems, micro and nano technologies, and solar and power systems. This book also Explores emerging technologies and their application in a broad range of engineering disciplines Examines fiber optics and laser technologies Covers biomedical, electrical, industrial, and mechanical systems Discusses multimedia systems and applications, computer vision and image & video signal processing.

  13. Test Methods for Evaluating Solid Waste, Physical/Chemical Methods. First Update. (3rd edition)

    International Nuclear Information System (INIS)

    Friedman; Sellers.

    1988-01-01

    The proposed Update is for Test Methods for Evaluating Solid Waste, Physical/Chemical Methods, SW-846, Third Edition. Attached to the report is a list of methods included in the proposed update indicating whether the method is a new method, a partially revised method, or a totally revised method. Do not discard or replace any of the current pages in the SW-846 manual until the proposed update I package is promulgated. Until promulgation of the update package, the methods in the update package are not officially part of the SW-846 manual and thus do not carry the status of EPA-approved methods. In addition to the proposed Update, six finalized methods are included for immediate inclusion into the Third Edition of SW-846. Four methods, originally proposed October 1, 1984, will be finalized in a soon to be released rulemaking. They are, however, being submitted to subscribers for the first time in the update. These methods are 7211, 7381, 7461, and 7951. Two other methods were finalized in the 2nd Edition of SW-846. They were inadvertantly omitted from the 3rd Edition and are not being proposed as new. These methods are 7081 and 7761

  14. 3rd International Conference on Photonics, Optics and Laser Technology

    CERN Document Server

    Raposo, Maria

    2016-01-01

    The book provides a collection of selected papers presented to the third International Conference on Photonics, Optics and Laser Technology PHOTOPTICS 2015, covering the three main conference scientific areas of “Optics”, “Photonics” and “Lasers”. The selected papers, in two classes full and short, result from a double blind review carried out by the conference program committee members which are highly qualified experts in conference topic areas.

  15. Sport concussion assessment tool - 3rd edition - normative reference values for professional ice hockey players.

    Science.gov (United States)

    Hänninen, Timo; Tuominen, Markku; Parkkari, Jari; Vartiainen, Matti; Öhman, Juha; Iverson, Grant L; Luoto, Teemu M

    2016-08-01

    To determine normative reference values for the Sport Concussion Assessment Tool-3rd Edition (SCAT3) using a large sample of professional male ice hockey players. A descriptive cross-sectional study. Preseason baseline testing was administered individually to 304 professional male ice hockey players. The participants were aged between 16 and 40 with a mean (M) age of 25.3 years. Over 60% of the athletes reported previous concussion, almost 20% had been hospitalized or medically imaged following a head trauma. Of the players, 48% reported no symptoms. The symptom score median (Md) was 1.0 (M=1.5) and severity median was 1.0 (M=2.3). The median of the SAC score was 27.0 (M=27.0). The median of the M-BESS was 1.0 (M=2.0). The Tandem gait median was 10.9s (M=10.8s). The most common baseline symptom was neck pain (24%). Delayed recall was the most difficult component of the SAC (Md=4); only 24% performed it flawlessly. All athletes completed the double-leg stance of the M-BESS without errors, but there was performance variability in the tandem stance (Md=0, M=0.6, range=0-10) and single-leg stance (Md=1.0, M=1.4, range=0-10). Representative normative reference values for the SCAT3 among professional male ice hockey players are provided. Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  16. The EPR - technology for the 3rd millennium

    International Nuclear Information System (INIS)

    Bernstrauch, O.; Dubois, F.

    2001-01-01

    This paper is a story of a successful Franco-German co-operation: the EPR project. It is a rundown of the history of the EPR, before a decision is made to launch the lead-unit construction. The EPR is expected to progressively replace the existing nuclear power plants when they will reach the end of their service life. It integrates the latest technological advances, especially in safety and operational aspects and comprises more than 30 years operating experience. Thus, the EPR combines the qualities of its predecessors, the French N4 and the German Konvoi. The safety of the EPR was maximized both to prevent hypothetical accidents - even severe ones - and to reduce their consequences (corium spreading area, pre-stressed double containment with local liner, four-train safety systems...). The n+2 strategy (in the event of a problem with one train and even if a second train is undergoing maintenance, the remaining two are sufficient to perform the function) allows to perform maintenance during operation which leads consequently to short outage periods, highest availabilities and economical operation. Moreover, most of the EPR components are the result of mastered evolution. The reactor vessel, as a key element for the reactor service life, is designed to be in service for 60 years, the core is large (241 fuel elements instead of 205 in the N4 or 193 in the Konvoi) and the steam generators have higher efficiency. Along the same line, the core and core barrel design have been modified to allow a reduced uranium enrichment and the increase to 65 Gigawatt-day per metric-ton of the fuel discharge burn-up. Finally, the instrumentation and control systems minimize human error by giving the operators a grace period of at least 30 minutes to make decisions. (authors)

  17. A global drought climatology for the 3rd edition of the World Atlas of Desertification (WAD)

    Science.gov (United States)

    Spinoni, Jonathan; Carrao, Hugo; Naumann, Gustavo; Antofie, Tiberiu; Barbosa, Paulo; Vogt, Jürgen

    2013-04-01

    A new version of the World Atlas of Desertification (WAD) is being compiled in the framework of cooperation between the Joint Research Centre (JRC) of the European Commission and the United Nations Environment Programme (UNEP). This initiative aims at mapping the global land degradation and desertification, as well as introducing the reader with complex interactions of geo-physical, socio-economic, and political aspects that affect the environmental sustainability. Recurrent extreme events resulting from climate change, such as more severe droughts, combined with non-adapted land use practices can affect the resilience of ecosystems tipping them into a less productive state. Thus, to describe the effects of climatological hazards on land degradation and desertification processes, we computed a World drought climatology that will be part of the 3rd edition of the WAD and will replace and update to 2010 the results presented in the 2nd edition in 1997. This paper presents the methodology used to compute three parameters included in the WAD drought climatology, i.e. drought frequency, intensity and duration, and discusses their spatio-temporal patterns both at global and continental scales. Because drought is mainly driven and triggered by a rainfall deficit, we chose the Standardized Precipitation Index (SPI) as the drought indicator to estimate our climatological parameters. The SPI is a statistical precipitation-based drought indicator widely used in drought-related studies. We calculated the SPI on three different accumulation periods: 3 months (SPI-3), 6 months (SPI-6), and 12 months (SPI-12), in order to take into account meteorological, agricultural, and hydrological drought-related features. Each quantity has been calculated on a monthly basis using the baseline period between January 1951 and December 2010. As data input, we used the Full Data Reanalysis Version 6.0 (0.5˚x0.5˚) of gridded monthly precipitation provided by the Global Precipitation

  18. Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities , 3rd edition

    OpenAIRE

    Jamison, Dean T; Alwan, Ala; Mock, Charles N; Nugent, Rachel; Watkins, David; Adeyi, Olusoji; Anand, Shuchi; Atun, Rifat; Bertozzi, Stefano; Bhutta, Zulfiqar; Binagwaho, Agnes; Black, Robert; Blecher, Mark; Bloom, Barry R; Brouwer, Elizabeth

    2017-01-01

    The World Bank is publishing nine volumes of Disease Control Priorities, 3rd edition (DCP3) between 2015 and 2018. Volume 9, Improving Health and Reducing Poverty, summarises the main messages from all the volumes and contains cross-cutting analyses. This Review draws on all nine volumes to convey conclusions. The analysis in DCP3 is built around 21 essential packages that were developed in the nine volumes. Each essential package addresses the concerns of a major professional community (eg, ...

  19. A procedure for safety assessment of components with cracks - Handbook. 3rd revised edition

    International Nuclear Information System (INIS)

    Andersson, P.; Bergman, M.; Brickstad, B.; Dahlberg, L.; Nilsson, F.; Sattari-Far, I.

    1999-12-01

    , the handbook contains solutions for the stress intensity factor and the limit load for a number of crack geometries of importance for applications. It also contains rules for defect characterization, recommendations for estimation of residual stresses, material data for nuclear applications and a safety evaluation system. To ensure conservatism, the procedure with the given solutions of the stress intensity factor and the limit load has been validated. Predictions of the procedure were compared with the actual outcome of full scale experiments reported in the literature. The first edition of the handbook was released in 1990 and the second in 1991. This third edition has been extensively revised. A new safety evaluation system has been introduced. The conservatism in the method for assessment of secondary stresses has been reduced. The solutions for the stress intensity factor and the limit load, the recommendations for estimation of residual stresses and the given material data for nuclear applications have been updated. A modern Windows based PC-program SACC has been developed which can perform the assessments described in this handbook including calculation of crack growth due to stress corrosion and fatigue. The program also has an option which enables assessment of cracks according to the 1995 edition of the ASME Boiler and Pressure Vessel Code, Section XI. Appendices A, C and H for assessment of cracks in ferritic pressure vessels, austenitic piping and ferritic piping, respectively

  20. 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications

    CERN Document Server

    Koziel, Slawomir; Kacprzyk, Janusz; Leifsson, Leifur; Ören, Tuncer

    2015-01-01

    This book includes extended and revised versions of a set of selected papers from the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2013) which was co-organized by the Reykjavik University (RU) and sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC). SIMULTECH 2013 was held in cooperation with the ACM SIGSIM - Special Interest Group (SIG) on SImulation and Modeling (SIM), Movimento Italiano Modellazione e Simulazione (MIMOS) and AIS Special Interest Group on Modeling and Simulation (AIS SIGMAS) and technically co-sponsored by the Society for Modeling & Simulation International (SCS), Liophant Simulation, Simulation Team and International Federation for Information Processing (IFIP). This proceedings brings together researchers, engineers, applied mathematicians and practitioners working in the advances and applications in the field of system simulation.

  1. 3rd ACIS International Conference on Applied Computing and Information Technology

    CERN Document Server

    2016-01-01

    This edited book presents scientific results of the 3nd International Conference on Applied Computing and Information Technology (ACIT 2015) which was held on July 12-16, 2015 in Okayama, Japan. The aim of this conference was to bring together researchers and scientists, businessmen and entrepreneurs, teachers, engineers, computer users, and students to discuss the numerous fields of computer science and to share their experiences and exchange new ideas and information in a meaningful way. Research results about all aspects (theory, applications and tools) of computer and information science, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.

  2. ic-cmtp3: 3rd International Conference on Competitive Materials and Technology Processes

    Science.gov (United States)

    2016-04-01

    Competitiveness is one of the most important factors in our lives and it plays a key role in the efficiency both of organizations and societies. The more scientifically advanced and prepared organizations develop more competitive materials with better physical, chemical, and biological properties, and the leading companies apply more competitive equipment and technological processes. The aims of the 3rd International Conference on Competitive Materials and Technology Processes (ic-cmtp3), and the 1st International Symposium on Innovative Carbons and Carbon Based Materials (is-icbm1) and the 1st International Symposium on Innovative Construction Materials (is-icm1) organized alongside are the following: —Promote new methods and results of scientific research in the fields of material, biological, environmental and technological sciences; —Exchange information between the theoretical and applied sciences as well as technical and technological implementations; —Promote communication and collaboration between the scientists, researchers and engineers of different nations, countries and continents. Among the major fields of interest are advanced and innovative materials with competitive characteristics, including mechanical, physical, chemical, biological, medical and thermal, properties and extreme dynamic strength. Their crystalline, nano - and micro-structures, phase transformations as well as details of their technological processes, tests and measurements are also in the focus of the ic-cmtp3 conference and the is-scbm1 and is-icm1 symposia. Multidisciplinary applications of material science and the technological problems encountered in sectors like ceramics, glasses, thin films, aerospace, automotive and marine industries, electronics, energy, construction materials, medicine, biosciences and environmental sciences are of particular interest. In accordance with the program of the ic-cmtp3 conference and is-icbm1 and is-icm1 symposia we have received more

  3. Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition.

    Science.gov (United States)

    Jamison, Dean T; Alwan, Ala; Mock, Charles N; Nugent, Rachel; Watkins, David; Adeyi, Olusoji; Anand, Shuchi; Atun, Rifat; Bertozzi, Stefano; Bhutta, Zulfiqar; Binagwaho, Agnes; Black, Robert; Blecher, Mark; Bloom, Barry R; Brouwer, Elizabeth; Bundy, Donald A P; Chisholm, Dan; Cieza, Alarcos; Cullen, Mark; Danforth, Kristen; de Silva, Nilanthi; Debas, Haile T; Donkor, Peter; Dua, Tarun; Fleming, Kenneth A; Gallivan, Mark; Garcia, Patricia J; Gawande, Atul; Gaziano, Thomas; Gelband, Hellen; Glass, Roger; Glassman, Amanda; Gray, Glenda; Habte, Demissie; Holmes, King K; Horton, Susan; Hutton, Guy; Jha, Prabhat; Knaul, Felicia M; Kobusingye, Olive; Krakauer, Eric L; Kruk, Margaret E; Lachmann, Peter; Laxminarayan, Ramanan; Levin, Carol; Looi, Lai Meng; Madhav, Nita; Mahmoud, Adel; Mbanya, Jean Claude; Measham, Anthony; Medina-Mora, María Elena; Medlin, Carol; Mills, Anne; Mills, Jody-Anne; Montoya, Jaime; Norheim, Ole; Olson, Zachary; Omokhodion, Folashade; Oppenheim, Ben; Ord, Toby; Patel, Vikram; Patton, George C; Peabody, John; Prabhakaran, Dorairaj; Qi, Jinyuan; Reynolds, Teri; Ruacan, Sevket; Sankaranarayanan, Rengaswamy; Sepúlveda, Jaime; Skolnik, Richard; Smith, Kirk R; Temmerman, Marleen; Tollman, Stephen; Verguet, Stéphane; Walker, Damian G; Walker, Neff; Wu, Yangfeng; Zhao, Kun

    2017-11-24

    The World Bank is publishing nine volumes of Disease Control Priorities, 3rd edition (DCP3) between 2015 and 2018. Volume 9, Improving Health and Reducing Poverty, summarises the main messages from all the volumes and contains cross-cutting analyses. This Review draws on all nine volumes to convey conclusions. The analysis in DCP3 is built around 21 essential packages that were developed in the nine volumes. Each essential package addresses the concerns of a major professional community (eg, child health or surgery) and contains a mix of intersectoral policies and health-sector interventions. 71 intersectoral prevention policies were identified in total, 29 of which are priorities for early introduction. Interventions within the health sector were grouped onto five platforms (population based, community level, health centre, first-level hospital, and referral hospital). DCP3 defines a model concept of essential universal health coverage (EUHC) with 218 interventions that provides a starting point for country-specific analysis of priorities. Assuming steady-state implementation by 2030, EUHC in lower-middle-income countries would reduce premature deaths by an estimated 4·2 million per year. Estimated total costs prove substantial: about 9·1% of (current) gross national income (GNI) in low-income countries and 5·2% of GNI in lower-middle-income countries. Financing provision of continuing intervention against chronic conditions accounts for about half of estimated incremental costs. For lower-middle-income countries, the mortality reduction from implementing the EUHC can only reach about half the mortality reduction in non-communicable diseases called for by the Sustainable Development Goals. Full achievement will require increased investment or sustained intersectoral action, and actions by finance ministries to tax smoking and polluting emissions and to reduce or eliminate (often large) subsidies on fossil fuels appear of central importance. DCP3 is intended to

  4. PREFACE: 3rd Iberian Meeting on Aerosol Science and Technology (RICTA 2015)

    Science.gov (United States)

    Orza, J. A. G.; Costa, M. J.

    2015-12-01

    The Third Iberian Meeting on Aerosol Science and Technology (RICTA 2015) was held in the city of Elche (province of Alicante, Spain) from 29 June to 1 July 2015, at Centro de Congresos Ciutat d'Elx. This event was organized and hosted by the Statistical and Computational Physics Laboratory (SCOLAb) of Universidad Miguel Hernández under the auspices of AECyTA, the Spanish Association for Aerosol Science and Technology Research. As in previous editions, the participation of young researchers was especially welcome, with the organization of the VI Summer School on Aerosol Science and Technology and awards for the best poster and PhD thesis, in recognition of outstanding research or presentations focusing on aerosols, during the early stage of their scientific career. RICTA 2015 aims to present the latest research and advances on the field of aerosols, as well as fostering interaction among the Portuguese and Spanish communities. The meeting gathered over 70 participants from 7 different countries, covering a wide range of aerosol science and technology. It included invited lectures, keynote talks, and several specialized sessions on different issues related to atmospheric aerosols, radiation, instrumentation, fundamental aerosol science, bioaerosols and health effects. The editors would like to express their sincere gratitude to all the participants, in particular, those who contributed to this special issue by submitting their papers to convey the current science discussed at RICTA 2015. In this special issue a series of peer-reviewed papers that cover a wide range of topics are presented: aerosol formation, emission, as well as aerosol composition in terms of physical and optical properties, spatial/temporal distribution of aerosol parameters, aerosol modeling and atmospheric effects, as well as instrumentation devoted to aerosol measurements. Finally, we also thank the referees for their valuable revision of these papers.

  5. International Classification of Headache Disorders 3rd edition beta-based field testing of vestibular migraine in China: Demographic, clinical characteristics, audiometric findings and diagnosis statues.

    Science.gov (United States)

    Zhang, Yixin; Kong, Qingtao; Chen, Jinjin; Li, Lunxi; Wang, Dayan; Zhou, Jiying

    2016-03-01

    This study explored the clinical characteristics of vestibular migraine in Chinese subjects and performed a field test of the criteria of the International Classification of Headache Disorders 3rd edition beta version. Consecutive patients with vestibular migraine were surveyed and registered in a headache clinic during the study period. The diagnosis of vestibular migraine was made according to International Classification of Headache Disorders 3rd edition beta version. Assessments included standardized neuro-otology bedside examination, pure-tone audiogram, bithermal caloric testing, neurological imaging, cervical X-ray or magnetic resonance imaging, Doppler ultrasound of cerebral arteries and laboratory tests. A total of 67 patients (62 female/five male, 47.8 ± 10.3 years old) were enrolled in this study. The mean ages of migraine and vertigo onset were 32.2 ± 11.5 and 37.9 ± 10.1 years, respectively. The most common migraine subtype was migraine without aura (79%), followed by migraine with aura (12%) and chronic migraine (9%). The duration of vertigo attacks varied from seconds to days and 25% of patients had attacks that lasted less than 5 minutes. Among the patients with short-lasting attacks, 75% of these patients had ≥5 attacks per day within 72 hours. Auditory symptoms were reported in 36% of the patients. Migraine prophylactic treatments were effective in 77% of the patients. Our study showed that the clinical features of vestibular migraine in China were similar to those of Western studies. The definition of vertigo episodes and migraine subtypes of vestibular migraine in International Classification of Headache Disorders 3rd edition beta version might be modified further. More than five vertigo attacks per day within 72 hours might be helpful as far as identifying vestibular migraine patients with short-lasting attacks. © International Headache Society 2015.

  6. Star Ware: The Amateur Astronomer's Guide to Choosing, Buying, and Using Telescopes and Accessories, 3rd Edition

    Science.gov (United States)

    Harrington, Philip S.

    2002-05-01

    Praise for the Second Edition of Star Ware "Star Ware is still a tour de force that any experienced amateur will find invaluable, and which hardware-minded beginners will thoroughly enjoy." -Robert Burnham, Sky & Telescope magazine "Star Ware condenses between two covers what would normally take a telescope buyer many months to accumulate." -John Shibley, Astronomy magazine Now more than ever, the backyard astronomer has a dazzling array of choices when it comes to telescope shopping-which can make choosing just the right sky-watching equipment a formidable challenge. In this revised and updated edition of Star Ware, the essential guide to buying astronomical equipment, award-winning astronomy writer Philip Harrington does the work for you, analyzing and exploring today's astronomy market and offering point-by-point comparisons of everything you need. Whether you're an experienced amateur astronomer or just getting started, Star Ware, Third Edition will prepare you to explore the farthest reaches of space with: Extensive, expanded reviews of leading models and accessories, including dozens of new products, to help you buy smart A clear, step-by-step guide to all aspects of purchasing everything from telescopes and binoculars to filters, mounts, lenses, cameras, film, star charts, guides and references, and much more Eleven new do-it-yourself projects for making unique astronomical equipment at home Easy tips on maintenance, photography, and star-mapping to help you get the most out of your telescope Lists of where to find everything astronomical, including Internet sites and Web resources; distributors, dealers, and conventions; and corporate listings for products and services

  7. “Patenting Bioprinting Technologies in the US and Europe– The 5th element in the 3rd dimension"

    DEFF Research Database (Denmark)

    Minssen, Timo; Mimler, Marc

    2017-01-01

    and scientific efforts in this technology will made, this is an utterly important question. In addition to trade secrets, copyrights, trademarks and other IPR-related rights, patents will certainly play a major role in that respect and will be at the focus of this paper. In this paper, we examine what sorts...... exclusions from patent law (4), which will allow us to complete the paper with some concluding remarks (5). Suggested Citation: Minssen, Timo and Mimler, Marc, Patenting Bioprinting-Technologies in the US and Europe– the 5th Element in the 3rd Dimension (April 4, 2017). Minssen, T & Mimler, M 2017...

  8. 3rd International Meeting for Researchers in Materials and Plasma Technology (IMRMPT) and 1st Symposium on Nanoscience and Nanotechnology

    International Nuclear Information System (INIS)

    2016-01-01

    These proceedings present the written contributions of the participants of the 3rd International Meeting for Researchers in Materials and Plasma Technology (3rd IMRMPT) and the 1st Symposium on Nanoscience and Nanotechnology which was held from 4 to May 9, 2015 at the Dann Carlton Hotel Bucaramanga, Colombia, organized by the faculty of science of the Universidad Industrial de Santander (UIS) and the basic science department of the Universidad Pontificia Bolivariana. This was the third version of biennial meetings that began in 2011. The five-day scientific program of the 3rd IMRMPT consisted of 24 Magisterial Conferences, 70 Oral Presentations, 185 Poster Presentations, 3 Courses and 1 Discussion Panel with the participation of undergraduate and graduate students, professors, researchers and entrepreneurs from Colombia, Russia, Germany, France, Spain, England, United States, Mexico, Argentina, Uruguay, Brazil, Venezuela, among others. Moreover, the objective of IMRMPT was to bring together national and international researchers in order to establish a network of scientific cooperation with a global impact in the area of the science and the technology of materials; to promote the exchange of creative ideas and the effective transfer of scientific knowledge, from fundamental research to innovation applied to industrial solutions and to advances in the development of new research allowing to increase the lifetime of the materials used in the industry by means of efficient transference of the knowledge between sectors academia and industry. The topics covered in the 3rd IMRMPT include New Materials, Surface Physics, Structural Integrity, Renewable Energy, Online Process Control, Non Destructive Evaluation, Characterization of Materials, Laser and Hybrid Processes, Thin Films and Nanomaterials, Surface Hardening Processes, Wear and Corrosion/Oxidation, Plasma Applications and Technologies, Modelling, Simulation and Diagnostics, Biomedical Coatings, Surface Treatments

  9. Intelligence and Technology. Joint Force Quarterly, Issue 46, 3rd Quarter 2007

    National Research Council Canada - National Science Library

    Gurney, David H

    2007-01-01

    ...: Intelligence Support to an Effects-based Approach, by James B. Ellsworth; Applying Law Enforcement Technology to Counterinsurgency Operations, by Giles Kyser, Matt Keegan, and Samuel A. Musa; China's ASAT Test...

  10. Grand challenges in technology enhanced learning outcomes of the 3rd Alpine Rendez-Vous

    CERN Document Server

    Fischer, Frank; Sutherland, Rosamund; Zirn, Lena

    2014-01-01

    This book presents a key piece of the vision and strategy developed in STELLAR. It sets out a new mid-term agenda by defining Grand Challenges for research and development in technology-enhanced learning. Other than mere technology prizes, STELLAR Grand Challenges deal with problems at the interface of social and technical sciences. They pose problems that can be solved only in interdisciplinary collaboration. The descriptions of the Grand Challenge Problems were sent out to a number of stakeholders from industry, academia, and policy-making who responded with insightful, creative and critical comments bringing in their specific perspectives. This book will inspire everyone interested in TEL and its neighboring disciplines in their future projects. All of the listed problems, first hints with respect to the approach, measurable success indicators and funding sources are outlined. The challenges focus on what noted experts regard as important upcoming, pending, and innovative fields of research, the solution o...

  11. Gene-based technologies for livestock industries in the 3rd millennium

    International Nuclear Information System (INIS)

    Cunningham, E.P.

    2005-01-01

    The first complete genome sequence of an organism was for yeast, in 1996. Since then, the much larger task of doing a complete human sequence has been completed. Those of major domestic animals are following rapidly. It will always be impossible to foresee the full potential of such an explosion in knowledge, but aspects of gene-based technologies are already beginning to have an impact in the livestock sector. The first and most obvious area of impact concerns feed supply, which constitutes 50-75 percent of total costs in many livestock systems. Production costs for maize and soybean are being reduced by genetic modification of the crop for herbicide and insect resistance. Maize has been modified to reduce phosphorous and nitrogen excretion in swine and poultry, and also to provide a more valuable amino acid balance. Genetic modification of the animal is also possible. Most dramatically, the insertion of a growth hormone in the DNA of fish accelerates growth. However, in this and all other cases, the genetic modification (GM) of animals has produced profound physiological disturbances. At the same time, the administration of GM-produced growth hormone to dairy cows is now routine in the United States of America and several other countries. This is not permitted in Europe, where the attitude to all GM technologies has been much more cautious. Conventional selection programmes continue to deliver steady genetic improvement in all animal populations. New molecular methods offer the prospect of enhancing genetic gains, particularly for traits that are difficult or expensive to measure, or which have low heritability. Gene technologies have much to contribute to the control of disease in animals. As pressure to reduce antibiotic and drug use increases, genetically modified vaccines with proven specificity and distinguishable from natural infections are already in use. DNA typing is helping with rapid and precise diagnosis. In addition, the interaction of some pathogens

  12. Diesel Technology: Introduction. Teacher Edition [and] Student Edition. Second Edition.

    Science.gov (United States)

    Joerschke, John D.; Eichhorn, Lane

    This complete teacher edition of a diesel technology course consists of introductory pages, teacher pages, and the student edition. The introductory pages provide these tools: training and competency profile; National Automotive Technicians Education Foundation Crosswalk; instructional/task analysis; basic skills icons and classifications; basic…

  13. Proceedings of the 3rd Workshop of R and D and technologies on Radioactive Waste management. Vol. 1,2

    International Nuclear Information System (INIS)

    1998-01-01

    The sessions present at the 3rd workshops on radioactive waste management are: 1. Bases for the radioactive waste management 2. Capsule fuel barrier 3. Barriers for engineering 4. Geologic barriers 5. The biosphere as barrier

  14. Leukocyte DNA damage after reduced and conventional absorbed radiation doses using 3rd generation dual-source CT technology

    Directory of Open Access Journals (Sweden)

    Henning D. Popp

    2016-01-01

    Conclusion: Our results provide evidence that reduced absorbed doses mediated by adjusted tube current in 3rd generation DSCT induce lower levels of DNA damage in PBMC compared to conventional absorbed doses suggesting a lower genotoxic risk for state-of-the-art tube current reduced CT protocols.

  15. 3rd DAtF-seminar on the development of potential for young scientists and engineers in nuclear technology

    International Nuclear Information System (INIS)

    Gassner, H.

    2003-01-01

    The 3 rd seminar organized by the Deutsches Atomforum e.V. for young nuclear scientists and engineers seeking to realize their potential was about 'Communication - Key to Acceptance'. The topic was presented in contributions outlining the scientific viewpoint and in results of practical everyday experience. The young participants from all areas of the nuclear industry were sensitized to the problem areas under discussion, which were then debated in more detail. Reference was made to the importance of continuous communication with all participants. The seminar offered valuable suggestions for working with the media and the public, but also for handling information in one's daily work. (orig.)

  16. Who's Where in the American Theatre: A Directory of Affiliated Theatre Artists in the U.S.A. 3rd Edition.

    Science.gov (United States)

    1992

    Expanded by more than 40% over previous editions, this directory provides accurate contact information for practitioners and teachers affiliated with organizations with proven records of production, publication or promotion of or service to the national theatre community. The first section of the directory provides an alphabetical listing of over…

  17. Selected Abstracts of the 3rd Edition of Transport of High Risk Infants; Oxford (UK; August 31st-September 2nd, 2017

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-08-01

    Full Text Available Selected Abstracts of the 3rd Edition of Transport of High Risk Infants; Oxford (UK; August 31st-September 2nd, 2017ABS 1. MORTALITY RATE IN 23-30 WEEKS PRE­MATURE BORN IN LEVEL 2 HOSPITAL IN COMPARISON TO THOSE BORN IN TERTIARY-CARE HOSPITAL • J.P. Doray, J.L. DorayABS 2. THE QUEBEC AEROMEDICAL EXPERIENCE: EVACUATION OF NEONATES FROM AREAS IN EXTREME WEATHER CONDITIONS – IN­NOVATIONS IN SAFETY AND EFFICIENCY • É. Notebaert, J. Provencher, R. Bernier, S. Côté, S. KindABS 3. NASAL HIGH FLOW SUPPORT DURING NEONATAL RETRIEVAL IN VICTORIA, AUSTRALIA • V. Abraham, C. Roberts, B. Manley, L. Owen, M. Stewart, P. DavisABS 4. NEONATAL TRANSPORT TO AND FROM A REGIONAL LEVEL 2 CENTRE • C. Moore, M. Cassidy, M. Byrne, A. Bowden, J. Franta, I. Farombi, J. FitzsimonsABS 5. PASSIVE THERAPEUTIC HYPOTHERMIA DURING AMBULANCE AND HELICOPTER SECONDARY NEONATAL TRANSPORT IN NEONATES WITH HYPOXIC BRAIN INJURY: 10-YEARS RETROSPECTIVE SURVEY • M. Leben, M. Nolimal, I. Vidmar, S. GrosekABS 6. STABILIZATION OF CRITICALLY ILL NEW­BORNS: PREVENTION OF ACUTE KIDNEY INJURY • A. Babintseva, Y. Hodovanets, L. AgafonovaABS 7. TRANSPORT OF THE SURGICAL NEONATES • R. Pejaver, A. Poveidein, D. Winterbank-Scott, C. Keys, N. GuptaABS 8. AUDIT OF VENTILATED NEONATAL TRANS­FERS IN NORTHERN IRELAND FROM 1ST JANUARY 2017 UNTIL 1ST MAY 2017 • R. Moore, S. KnoxABS 9. “HUB AND SPOKE” ECMO IN NEONATES WITH MECONIUM ASPIRATION SYNDROME: A PRELIMINARY REPORT • N. Doglioni, D. Fichera, F. Zanella, M. Padalino, V. Vida, G. Stellin, P. Lago, D. TrevisanutoABS 10. INTRA-HOSPITAL TRANSPORTATION OF EX­TREMELY PRETERM INFANTS AND INCI­DENCE OF INTRAVENTRICULAR HAEMOR­RHAGES • N. Wadström, M. Breindahl, B. Hallberg, B. SkiöldABS 11. RISK OF POSTNATAL TRANSPORT AND OUT­COME OF LATE PRETERM INFANTS BORN AT NON-TERTIARY CENTRES: A RETRO­SPEC­TIVE COHORT STUDY • N. Doglioni, L. Salmaso, P. Facchin, D. TrevisanutoABS 12. COMPARING THREE METHODS OF THERA

  18. Technology Catalogue. First edition

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    The Department of Energy`s Office of Environmental Restoration and Waste Management (EM) is responsible for remediating its contaminated sites and managing its waste inventory in a safe and efficient manner. EM`s Office of Technology Development (OTD) supports applied research and demonstration efforts to develop and transfer innovative, cost-effective technologies to its site clean-up and waste management programs within EM`s Office of Environmental Restoration and Office of Waste Management. The purpose of the Technology Catalogue is to provide performance data on OTD-developed technologies to scientists and engineers assessing and recommending technical solutions within the Department`s clean-up and waste management programs, as well as to industry, other federal and state agencies, and the academic community. OTD`s applied research and demonstration activities are conducted in programs referred to as Integrated Demonstrations (IDs) and Integrated Programs (IPs). The IDs test and evaluate.systems, consisting of coupled technologies, at specific sites to address generic problems, such as the sensing, treatment, and disposal of buried waste containers. The IPs support applied research activities in specific applications areas, such as in situ remediation, efficient separations processes, and site characterization. The Technology Catalogue is a means for communicating the status. of the development of these innovative technologies. The FY93 Technology Catalogue features technologies successfully demonstrated in the field through IDs and sufficiently mature to be used in the near-term. Technologies from the following IDs are featured in the FY93 Technology Catalogue: Buried Waste ID (Idaho National Engineering Laboratory, Idaho); Mixed Waste Landfill ID (Sandia National Laboratories, New Mexico); Underground Storage Tank ID (Hanford, Washington); Volatile organic compound (VOC) Arid ID (Richland, Washington); and VOC Non-Arid ID (Savannah River Site, South Carolina).

  19. Technology catalogue. Second edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    The Department of Energy`s (DOE`s) Office of Environmental Management (EM) is responsible for remediating DOE contaminated sites and managing the DOE waste inventory in a safe and efficient manner. EM`s Office of Technology Development (OTD) supports applied research and demonstration efforts to develop and transfer innovative, cost-effective technologies to its site clean-up and waste-management programs within EM. The purpose of the Technology Catalogue is to: (a) provide performance data on OTD-developed technologies to scientists and engineers responsible for preparing Remedial Investigation/Feasibility Studies (RI/FSs) and other compliance documents for the DOE`s clean-up and waste-management programs; and (b) identify partnering and commercialization opportunities with industry, other federal and state agencies, and the academic community.

  20. Technology catalogue. Second edition

    International Nuclear Information System (INIS)

    1995-04-01

    The Department of Energy's (DOE's) Office of Environmental Management (EM) is responsible for remediating DOE contaminated sites and managing the DOE waste inventory in a safe and efficient manner. EM's Office of Technology Development (OTD) supports applied research and demonstration efforts to develop and transfer innovative, cost-effective technologies to its site clean-up and waste-management programs within EM. The purpose of the Technology Catalogue is to: (a) provide performance data on OTD-developed technologies to scientists and engineers responsible for preparing Remedial Investigation/Feasibility Studies (RI/FSs) and other compliance documents for the DOE's clean-up and waste-management programs; and (b) identify partnering and commercialization opportunities with industry, other federal and state agencies, and the academic community

  1. Hydrogen utilization international clean energy system technology (WE-NET). Subtask 5. Development of technology of hydrogen transportation/storage (3rd edition, development of liquid hydrogen storage equipment, report on results of Air Liquide); Suiso riyo kokusai clean energy system gijutsu (WE-NET). Subtask 5. Suiso yuso chozo gijutsu no kaihatsu (daisanpen ekitai suiso chozo setsubi no kaihatsu Air Liquide sha seika hokoku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    In the fiscal 1995 study, items were searched which are keys to the design of a liquid hydrogen tanker of a capacity of 200,000m{sup 3}. Among those, the basic concepts were summarized which are necessary for the design of a liquid hydrogen tanker in terms of safety, and the extraporation of the existing low temperature technology into the large liquid hydrogen tank was studied. When adopting safety conditions of IGC Code applied to LNG to the liquid hydrogen tanker, it is necessary to limit the discharge amount of hydrogen to 3 kg/s. When considering safety at fire, for keeping safety of the same level as that of the LNG tanker, it is not appropriate to adopt the conventional vacuum insulation liquid hydrogen tank. In the fiscal 1995 study, 7 kinds of concept of the insulation structure were assumed, and it was concluded that BOR of 0.04-0.23/d was obtained. Also in fiscal 1996, the large liquid hydrogen tank was studied. For insulation of the large liquid hydrogen tank, the structure is most promising where AEROSIL bag or homogeneous AEROSIL is substituted for a forming heat insulating material of 4 design, but further study is needed for selection of the optimum heat insulating structure. 9 figs., 6 tabs.

  2. Funding of energy research: BMFT expenditures for energy research and energy technologies, 3rd program, a review and a forecast

    International Nuclear Information System (INIS)

    Jacke, S.

    1990-01-01

    Between the early sixties and late 1989, the German Federal Government spent some DM 23 billion to support research and development of the entire field of nuclear technology (such as fundamental research, industrial applications, medicine, safety technology, advanced energy systems) in the Federal Republic of Germany. Of this amount, approx. DM 11 billion was spent on the technology of nuclear power plants equipped with light water reactors, on safety research, and on the nuclear fuel cycle. Comparing the expenditures of the Federal Government for the conversion of nuclear power into electricity with the savings achieved in electricity generating costs of approx. DM 58 billion by late 1989 (the cost advantage of nuclear power being approx. Pf 5/kWh), one arrives at a cost advantage to the whole economy of approx. DM 47 billion by the date shown above; by the year 2000, this advantage will have risen to some DM 150 billion. (orig.) [de

  3. 3rd IDPASC School

    CERN Document Server

    Lectures on particle physics, astrophysics and cosmology

    2015-01-01

    This volume gathers the content of the courses held at the Third IDPASC School, which took place in San Martiño Pinario, Hospederia and Seminario Maior, in the city of Santiago de Compostela, Galiza, Spain, from January 21st to February 2nd, 2013. This school is the annual joint program of the International Doctorate Network in Particle Physics, Astrophysics, and Cosmology (IDPASC).   The purpose of the school series is to present doctoral students from different universities and laboratories in Europe and beyond with a broad range of the latest results and current state of the art in the fields of Particle Physics, Astrophysics, and Cosmology, and to further introduce them to both the questions now posed by the potentials of physics and to challenges connected with current and future experiments – in particular, with the newly available energy ranges.   Following these guidelines, the content of this third edition of the IDPASC School was jointly planned by the Academic Council and by the network’s In...

  4. 3rd annual biomass energy systems conference

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The main objectives of the 3rd Annual Biomass Energy Systems Conference were (1) to review the latest research findings in the clean fuels from biomass field, (2) to summarize the present engineering and economic status of Biomass Energy Systems, (3) to encourage interaction and information exchange among people working or interested in the field, and (4) to identify and discuss existing problems relating to ongoing research and explore opportunities for future research. Abstracts for each paper presented were edited separately. (DC)

  5. Nuclear and radiochemistry, 3rd edition

    International Nuclear Information System (INIS)

    Friedlander, G.; Kennedy, J.W.; Macias, E.S.; Miller, J.M.

    1981-01-01

    A broad coverage of radioactivity and nuclear phenomena fundamentals is presented, followed by discussions of applications in such fields as basic chemistry, biology, medicine, earth and space sciences. Following an introductory historical chapter, the basic fundamentals of nuclear properties, radioactive growth and decay, and nuclear reactions are covered in the first five chapters. Chapters 6-10 deal mainly with topics essential to the practicing radiochemist. They include discussion of interactions of radiation with matter, radiation detection and measurement, techniques in nuclear chemistry, statistics and radioactivity and nuclear models. Applications of these disciplines in the various fields noted above together with chapters on nuclear energy and sources of nuclear bombarding particles complete the 15 chapters of the book

  6. Short-term diagnostic stability of probable headache disorders based on the International Classification of Headache Disorders, 3rd edition beta version, in first-visit patients: a multicenter follow-up study.

    Science.gov (United States)

    Kim, Byung-Su; Moon, Heui-Soo; Sohn, Jong-Hee; Cha, Myong-Jin; Song, Tae-Jin; Kim, Jae-Moon; Park, Jeong Wook; Park, Kwang-Yeol; Cho, Soo-Jin; Kim, Soo-Kyoung

    2016-01-01

    A "Probable headache disorder" is diagnosed when a patient's headache fulfills all but one criterion of a headache disorder in the 3rd beta edition of the International Classification of Headache Disorder (ICHD-3β). We investigated diagnostic changes in probable headache disorders in first-visit patients after at least 3 months of follow-up. This was a longitudinal study using a prospective headache registry from nine headache clinics of referral hospitals. The diagnostic change of probable headache disorders at baseline was assessed at least 3 months after the initial visit using ICHD-3β. Of 216 patients with probable headache disorders at baseline, the initial probable diagnosis remained unchanged for 162 (75.0 %) patients, while it progressed to a definite diagnosis within the same headache subtype for 45 (20.8 %) by fulfilling the criteria during a median follow-up period of 6.5 months. Significant difference on the proportions of constant diagnosis was not found between headache subtypes (P headache (TTH), and 76.0 % for probable other primary headache disorders (OPHD). Among patients with headache recurrence, the proportion of constant diagnosis was higher for probable migraine than for probable TTH plus probable OPHD (59.2 vs. 23.1 %; P 3 and ≤ 6 months vs. > 6 and ≤ 10 months) in probable migraine, probable TTH, and probable OPHD, respectively. In this study, a probable headache diagnosis, based on ICHD-3β, remained in approximately three-quarters of the outpatients; however, diagnostic stability could differ by headache recurrence and subtype. Probable headache management might have to consider these differences.

  7. Diesel Technology: Engines. Second Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Barbieri, Dave; Miller, Roger; Kellum, Mary

    This diesel technology series offers secondary and postsecondary students an opportunity for learning required skills in the diesel industry. It aligns with the medium/heavy duty truck task list developed by the National Automotive Technicians Education Foundation and used by the National Institute for Automotive Service Excellence in…

  8. Power Technologies Data Book 2003 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2004-06-01

    The 2003 edition of this report, prepared by NREL's Energy Analysis Office, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts and comparisons, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, conversion factors, and selected congressional questions and answers.

  9. The commercialization of genome-editing technologies.

    Science.gov (United States)

    Brinegar, Katelyn; K Yetisen, Ali; Choi, Sun; Vallillo, Emily; Ruiz-Esparza, Guillermo U; Prabhakar, Anand M; Khademhosseini, Ali; Yun, Seok-Hyun

    2017-11-01

    The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.

  10. Diesel Technology: Safety Skills. Teacher Edition [and] Student Edition. Second Edition.

    Science.gov (United States)

    Kellum, Mary

    Teacher and student editions of this document are one in a series of competency-based instructional materials for diesel technology programs. The series aligns with the medium/heavy diesel duty truck task list used by the National Institute for Automotive Service Excellence in the certification of medium/heavy duty truck technicians. Introductory…

  11. Emerging technologies planning guide, 1993 edition

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    Information system technology enhancements during the next five years are expected to provide some of the most significant individual and organization work improvements ever made in the office environment. This guide is an aid to planning these technologies and assessing their roles in improving the effectiveness of Headquarters programs. Their implementation will cost-effectively support Departmental operations and the National Energy Strategy. At the hear of this process is an understanding of the relationship which exists between technology introduction and the planning, budgeting and acquisition process. The 1993 edition of this guide covers the 1993--1997 time frame.

  12. Proceedings of the Annual National Conference on Ada (Trademark) Technology (3rd) Held at Prarie View, Texas on 20-21 March 1985.

    Science.gov (United States)

    1985-01-01

    umeints WEIGHT SUMMNATION Figure 3. Ada Decision Matrix 90 Annual National Confefence on Ada Technology 1985 2., - .. ° •- , - Well written Ada code will...languages. candidates for recovery to the target environment is generated. Annual National Confefence on Ada Technology 1985 153 -.. • . . . .o

  13. Technology Roadmap: Wind Energy. 2013 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The IEA Wind Power Technology Roadmap 2013 Edition recognises the very significant progress made since the first edition was published in 2009. The technology continues to improve rapidly, and costs of generation from land-based wind installations continue to fall. Wind power is now being deployed in countries with good resources without any dedicated financial incentives. The 2013 Edition targets an increased share (15% to 18%) of global electricity to be provided by wind power in 2050, compared to 12% in the original roadmap of 2009. However, increasing levels of low-cost wind still require predictable, supportive regulatory environments and appropriate market designs. The challenges of integrating higher levels of variable wind power into the grid need to be addressed. For offshore wind, much remains to be done to develop appropriate large-scale systems and to reduce costs. The 2013 Wind Power Roadmap also provides updated analysis on the barriers that exist for the technology and suggests ways to address them, including legal and regulatory recommendations.

  14. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  15. 3rd International Conference on Ecosystem Assessment Management

    CERN Document Server

    Ma, Sheng-Quan; Cao, Hu-hua; Ecosystem Assessment and Fuzzy Systems Management

    2014-01-01

    “Ecosystem Assessment and Fuzzy Systems Management” is the edited outcome of the 3rd International Conference on Ecosystem Assessment Management (ICEAM) and the Workshop on the Construction of an Early Warning Platform for Eco-tourism (WCEWPE) in Hainan on May 5-12, 2013, Haikou, China. The 3rd ICEAM and the WCEWPE, built on the success of previous conferences, are major Symposiums for scientists, engineers and logistic management researchers presenting their the latest achievements, developments and applications in all areas of Ecosystem Assessment Management, Early Warning Platform for Eco-tourism and fuzziology. It aims to strengthen relations between industry research laboratories and universities, and to create a primary symposium for world scientists. The book, containing 47 papers, is divided into five parts: “Ecosystem Assessment, Management and Information”; “Intelligent Algorithm, Fuzzy Optimization and Engineering Application”; “Spatial Data Analysis and Intelligent Information Proces...

  16. Lecture Notes in Statistics. 3rd Semester

    DEFF Research Database (Denmark)

    The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models.......The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models....

  17. [Genome editing technology and its application in forage legumes].

    Science.gov (United States)

    Liu, Huan; Meng, Yingying; Niu, Lifang; Lin, Hao

    2017-10-25

    Genome editing is a novel targeted genome modification biotechnology, which could successfully mutate specific loci as well as generate gene replacement and insertion in various organisms. So far, genome editing technology has been widely applied in investigating gene function and developing valuable traits in both model plants and major crops. In this review, we briefly survey the historical development of genome editing technology, summarize recent progress using the CRISPR/Cas9 system for plant genome editing and explore the potential of the CRISPR/Cas technology in improving forage legumes.

  18. Genome editing: the breakthrough technology for inherited retinal disease?

    Science.gov (United States)

    Smith, Andrew J; Carter, Stephen P; Kennedy, Breandán N

    2017-10-01

    Genetic alterations resulting in a dysfunctional retinal pigment epithelium and/or degenerating photoreceptors cause impaired vision. These juxtaposed cells in the retina of the posterior eye are crucial for the visual cycle or phototransduction. Deficits in these biochemical processes perturb neural processing of images capturing the external environment. Notably, there is a distinct lack of clinically approved pharmacological, cell- or gene-based therapies for inherited retinal disease. Gene editing technologies are rapidly advancing as a realistic therapeutic option. Areas covered: Recent discovery of endonuclease-mediated gene editing technologies has culminated in a surge of investigations into their therapeutic potential. In this review, the authors discuss gene editing technologies and their applicability in treating inherited retinal diseases, the limitations of the technology and the research obstacles to overcome before editing a patient's genome becomes a viable treatment option. Expert opinion: The ability to strategically edit a patient's genome constitutes a treatment revolution. However, concerns remain over the safety and efficacy of either transplanting iPSC-derived retinal cells following ex vivo gene editing, or with direct gene editing in vivo. Ultimately, further refinements to improve efficacy and safety profiles are paramount for gene editing to emerge as a widely available treatment option.

  19. 3rd Semester and Master's Thesis Ideas

    DEFF Research Database (Denmark)

    Clausen, Johan

    The following pages contain a list of project ideas proposed by the scientific staff at the department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalouge may form the basis for long and short candidate projects as well as regular 3rd...

  20. The 3rd power unit roofing decontamination

    International Nuclear Information System (INIS)

    Samojlenko, Yu.N.; Golubev, V.V.

    1989-01-01

    The most features of the 3rd power unit (PU) roofing decontamination are described: 1) the most active materials were thrown into the 4th PU ruins before the Ukrytie construction completion; 2) the decontamination was fulfilled using remote-controlled mechanisms and manual devices (the main part). 6 figs.; 1 tab

  1. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    fascia of the Sartorius muscle. The skin flaps were brought in apposition and the edges were sutured with interrupted suture using Nylon. The suture on the skin was removed twelve days post surgery. POST OPERATIVE CARE. The bitch was injected Penicillin at the dose of. 10,000IU/Kg IM and Streptomycin at the dose.

  2. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    SUMMARY. Two hundred beef samples randomly collected from Bodija market in Ibadan, Nigeria were investigated bacteriologically. Four isolates resembling members of the Enterobacteriaceae family by phenotypic characterisation were further examined on MacConkey agar (MCA), Columbia agar with 5% ovine blood.

  3. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    Management: Following anesthesia with. 2mg/kg xylazine and 8mg/kg ketamine, the feather around the vent were carefully plucked and the area prepared for aseptic surgery. The prolapsed mass was cleared of debris with physiological saline flush, and terry towel soaked in cold physiological saline was wrapped around.

  4. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    percentages. The relationship between mean adult worm and nodule numbers and weight of condemned intestines were determined by the. Spearman's Rank Correlation Test at the 5% (P <. 0.05) level of significance (GraphPad, 2000). RESULTS. Prevalence and counts of Oesophagostomum nodules in sheep and goats.

  5. Entrepreneurship and Small Business : 3rd Asia-Pacific Edition

    OpenAIRE

    Schaper, Michael; Volery, Thierry; Weber, Paull; Lewis, Kate

    2010-01-01

    (See also PDF) PART 1 The nature of small business and entrepreneurship. CHAPTER 1 Entrepreneurship: definition and evolution. CHAPTER 2 The personality of entrepreneurs. CHAPTER 3 Creativity, innovation and entrepreneurship. CHAPTER 4 Small business: definitions and characteristics. PART 2 Getting into business. CHAPTER 5 Options for going into business. CHAPTER 6 Market research and strategy formulation. CHAPTER 7 Preparing a business plan. CHAPTER 7 ...

  6. Diagnosis and Fault-tolerant Control, 3rd Edition

    DEFF Research Database (Denmark)

    Blanke, Mogens; Kinnaert, Michel; Lunze, Jan

    The book presents effective model-based analysis and design methods for fault diagnosis and fault-tolerant control. Architectural and structural models are used to analyse the propagation of the fault through the process, to test the fault detectability and to find the redundancies in the process...... that can be used to ensure fault tolerance. It also introduces design methods suitable for diagnostic systems and fault-tolerant controllers for continuous processes that are described by analytical models of discrete-event systems represented by automata....

  7. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    The bacteriology results yielded no bacterial growth. However, mycology results yielded. Trychophyton verrucosum after 10 days of o incubation at 37 C using Sabroud dextrose agar medium (SDA). Skin scraping for parasitology yielded no parasite, fecal sample also yielded no parasite. Hemo-parasitology sample yielded.

  8. Machining Data Handbook. 3rd Edition. Volume 2

    Science.gov (United States)

    1980-01-01

    250 .004 Finishing CA601B CA60GB706 725 754 782 toAn e edo 710 745 757 100RS 715 752 770 • z, ii - 4me 35. COPPER ALLOYS, CAST 3500 100 .001 Roughing...of the international confer- ence on production engneering, 1974 (Part 1). p. 28. Japan Society of Precision Engineering, 1974) 10-30 Hydrodynamic...conditions, economy resulting from dilu- glycols, as blending agents and humectants; and germi- tion with water, better operator acceptance and improved

  9. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    relieve constipation in man and animals. Senna cinnamonum is the source of aromatic stomachic, ... feeding the plant to the animals. KEYWORDS: Senna obtusifolia, feedstuff, digestibility, ... Vol. 32(3): 2011; 199 - 203. ARTICLE. Utilization of Senna obtusifolia as a Potential Non-Conventional Feedstuff. In Sheep. 1. 2. 2. 1.

  10. Legal Concepts in Sport: A Primer. 3rd Edition

    Science.gov (United States)

    Carpenter, Linda Jean

    2008-01-01

    When most people think of legal issues in sport, they think about negligence. However, most professionals will face a much broader range of issues. For instance, topics such as sexual harassment, corporal punishment, drug testing, transportation, and hazing are all of special importance today. Also anti-discrimination laws and the concepts…

  11. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    Considering the proven efficacy of toltrazuril, it could serve as potential replacement for less effective anticoccidials in Nigeria. In this study, the efficacy of toltrazuril,. ® amprolium and Embazine Fort against experimental mixed Eimeria species infection in broiler chickens was compared. Nigerian Veterinary Journal. Vol.

  12. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    CBPP vaccine has been produced in Nigeria by National Veterinary. Research Institute (NVRI) Vom since 1924. The minimum age of vaccination of cattle is six month and the immunity ... Vaccination Coverage and Prevalence of Contagious Bovine Pleuropneumonia. (1999 - 2008) in ... and adverse tissue reaction. Several ...

  13. Vom work Book Journal, 2011 3rd Edition

    African Journals Online (AJOL)

    USER

    From each animal, a fore and hind quarter was taken to Veterinary. Anatomy Laboratory of Usmanu Danfodiyo. University, Sokoto (UDUS) for dissection. Supraspinatus, biceps brachii and triceps brachii muscles were dissected out from the fore quarter. (Plate 1) while semimembranosus, semitendinosus and gluteobiceps ...

  14. 3rd International Conference on Transcriptomics

    OpenAIRE

    John A Daniel

    2017-01-01

    Conference Series has been instrumental in conducting international Biochemistry meetings for seven years, and very excited to expand Europe, America and Asia Pacific continents. Previous meetings were held in major cities like Philadelphia, Orlando with success the meetings again scheduled in three continents. 3rd International Conference on Transcriptomics to be held during October 30 - November 01, 2017 at Bangkok, Thailand The Global Transcriptomics business sector to develop at a C...

  15. Modern Genome Editing Technologies in Huntington's Disease Research.

    Science.gov (United States)

    Malankhanova, Tuyana B; Malakhova, Anastasia A; Medvedev, Sergey P; Zakian, Suren M

    2017-01-01

    The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study NgAgo human diseases at the cellular and molecular levels. Gene editing tools like ZFN, TALEN, CRISPR-based systems, NgAgo and SGN can introduce different modifications. In gene sequences and regulate gene expression in different types of cells including induced pluripotent stem cells (iPSCs). These tools can be successfully used for Huntington's disease (HD) modeling, for example, to generate isogenic cell lines bearing different numbers of CAG repeats or to correct the mutation causing the disease. This review presents common genome editing technologies and summarizes the progress made in using them in HD and other hereditary diseases. Furthermore, we will discuss prospects and limitations of genome editing in understanding HD pathology.

  16. [Advances in genome editing technologies for treating muscular dystrophy.

    Science.gov (United States)

    Makita, Yukimasa; Hozumi, Hiroyuki; Hotta, Akitsu

    Recent advances in genome editing technologies have opened the possibility for treating genetic diseases, such as Duchenne muscular dystrophy(DMD), by correcting the causing gene mutations in dystrophin gene. In fact, there are several reports that demonstrated the restoration of the mutated dystrophin gene in DMD patient-derived iPS cell or functional recovery of forelimb grip strength in DMD model mice. For future clinical applications, there are several aspects that need to be taken into consideration:efficient delivery of the genome editing components, risk of off-target mutagenesis and immunogenicity against genome editing enzyme. In this review, we summarize the current status and future prospective of the research in applying genome editing technologies to DMD.

  17. Genome editing: a robust technology for human stem cells.

    Science.gov (United States)

    Chandrasekaran, Arun Pandian; Song, Minjung; Ramakrishna, Suresh

    2017-09-01

    Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells.

  18. 3rd MeTrApp Conference

    CERN Document Server

    Lovasz, Erwin-Christian; Hüsing, Mathias

    2015-01-01

    This volume deals with topics such as mechanism and machine design, biomechanics and medical engineering, gears, mechanical transmissions, mechatronics, computational and experimental methods, dynamics of mechanisms and machines, micromechanisms and microactuators, and history of mechanisms and transmissions. Following MeTrApp 2011 and 2013, held under the auspices of the IFToMM, these proceedings of the 3rd Conference on Mechanisms, Transmissions and Applications offer a platform for original research presentations for researchers, scientists, industry experts and students in the fields of mechanisms and transmissions with special emphasis on industrial applications in order to stimulate the exchange of new and innovative ideas.

  19. Diesel Technology: Steering and Suspension. Second Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Miller, Roger; Scarberry, Terry; Tesch, Carl; Kellum, Mary

    These teacher and student editions on steering and suspension are part of the diesel mechanics series of instructional materials. The series aligns with the medium/heavy duty truck task list developed by the National Automotive Technicians Education Foundation and used by the National Institute for Automotive Service Excellence in the…

  20. Current status and perspectives of genome editing technology for microalgae.

    Science.gov (United States)

    Jeon, Seungjib; Lim, Jong-Min; Lee, Hyung-Gwan; Shin, Sung-Eun; Kang, Nam Kyu; Park, Youn-Il; Oh, Hee-Mock; Jeong, Won-Joong; Jeong, Byeong-Ryool; Chang, Yong Keun

    2017-01-01

    Genome editing techniques are critical for manipulating genes not only to investigate their functions in biology but also to improve traits for genetic engineering in biotechnology. Genome editing has been greatly facilitated by engineered nucleases, dubbed molecular scissors, including zinc-finger nuclease (ZFN), TAL effector endonuclease (TALEN) and clustered regularly interspaced palindromic sequences (CRISPR)/Cas9. In particular, CRISPR/Cas9 has revolutionized genome editing fields with its simplicity, efficiency and accuracy compared to previous nucleases. CRISPR/Cas9-induced genome editing is being used in numerous organisms including microalgae. Microalgae have been subjected to extensive genetic and biological engineering due to their great potential as sustainable biofuel and chemical feedstocks. However, progress in microalgal engineering is slow mainly due to a lack of a proper transformation toolbox, and the same problem also applies to genome editing techniques. Given these problems, there are a few reports on successful genome editing in microalgae. It is, thus, time to consider the problems and solutions of genome editing in microalgae as well as further applications of this exciting technology for other scientific and engineering purposes.

  1. 3rd International Conference Nanotechnology and Nanomaterials

    CERN Document Server

    Yatsenko, Leonid

    2016-01-01

    This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 3rd International Science and Practice Conference Nanotechnology and Nanomaterials (NANO2015) held in Lviv, Ukraine on August 26-30, 2015. The International Conference was organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), Ivan Franko National University of Lviv (Ukraine), University of Turin (Italy), Pierre and Marie Curie University (France), and European Profiles A.E. (Greece). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications. Presents cutting-edge advances in nanocomposites and carbon and silicon-based nanomaterials for a wide range of engine...

  2. Classificação da Organização Mundial da Saúde para os tumores dos tecidos hematopoético e linfoide, 4ª edição, 2008: principais modificações introduzidas em relação à 3ª edição, 2001 World Health Organization classification of tumors of hematopoietic and lymphoid tissues, 4th edition, 2008: major changes from the 3rd edition, 2001

    Directory of Open Access Journals (Sweden)

    Maria Claudia Nogueira Zerbini

    2011-02-01

    Full Text Available A Classificação da Organização Mundial da Saúde (OMS para os tumores do tecido hematopoético e linfoide (4ª edição, 2008¹ representa uma atualização da 3ª edição, 2001². Apresentamos a seguir um resumo dessas alterações nos grupos das doenças mieloproliferativas, mileodisplásicas, leucemias mieloides agudas, neoplasias de células precursoras B e T, e neoplasias de células B, T e NK maduras. O entendimento das alterações genético-moleculares e os resultados alcançados com propostas terapêuticas inovadoras nesses grupos de doenças demandam constante reavaliação de sua classificação, justificando as alterações importantes aqui discutidas1,3-5.The World Health Organization (WHO Classification of tumors of hematopoietic and lymphoid tissues (4th edition, 2008¹ presents an updated version of the 3rd edition published in 2001². A summary of these changes relates to the groups of chronic myeloproliferative disorders, myelodisplasia, acute myeloid leukemias, neoplasms of precursor B and T cells and neoplasms derived of mature B, T and NK cells. A better understanding of molecular genetic changes and results achieved with innovative therapeutic approaches in these groups of diseases requires constant reassessment of the classifications, supporting the major changes discussed here, including interesting comments from literature1, 3-5.

  3. Power Technologies Energy Data Book - Third Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2005-04-01

    This report, prepared by NREL's Energy Analysis Office, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, and conversion factors.

  4. Power Technologies Energy Data Book - Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2006-08-01

    This report, prepared by NREL's Strategic Energy Analysis Center, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, and conversion factors.

  5. 3rd Conference on Ignition Systems for Gasoline Engines

    CERN Document Server

    Sens, Marc

    2017-01-01

    The volume includes selected and reviewed papers from the 3rd Conference on Ignition Systems for Gasoline Engines in Berlin in November 2016. Experts from industry and universities discuss in their papers the challenges to ignition systems in providing reliable, precise ignition in the light of a wide spread in mixture quality, high exhaust gas recirculation rates and high cylinder pressures. Classic spark plug ignition as well as alternative ignition systems are assessed, the ignition system being one of the key technologies to further optimizing the gasoline engine.

  6. BACODINE/3rd Interplanetary Network burst localization

    International Nuclear Information System (INIS)

    Hurley, K.; Barthelmy, S.; Butterworth, P.; Cline, T.; Sommer, M.; Boer, M.; Niel, M.; Kouveliotou, C.; Fishman, G.; Meegan, C.

    1996-01-01

    Even with only two widely separated spacecraft (Ulysses and GRO), 3rd Interplanetary Network (IPN) localizations can reduce the areas of BATSE error circles by two orders of magnitude. Therefore it is useful to disseminate them as quickly as possible following BATSE bursts. We have implemented a system which transmits the light curves of BACODINE/BATSE bursts directly by e-mail to UC Berkeley immediately after detection. An automatic e-mail parser at Berkeley watches for these notices, determines the Ulysses crossing time window, and initiates a search for the burst data on the JPL computer as they are received. In ideal cases, it is possible to retrieve the Ulysses data within a few hours of a burst, generate an annulus of arrival directions, and e-mail it out to the astronomical community by local nightfall. Human operators remain in this loop, but we are developing a fully automated routine which should remove them, at least for intense events, and reduce turn-around times to an absolute minimum. We explain the current operations, the data types used, and the speed/accuracy tradeoffs

  7. Biodetection Technologies for First Responders: 2014 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Ozanich, Richard M.; Baird, Cheryl L.; Bartholomew, Rachel A.; Colburn, Heather A.; Straub, Tim M.; Bruckner-Lea, Cindy J.

    2014-03-28

    This report summarizes commercially-available, hand-portable technologies that can be used by first responders in the field. This is not meant to be an exhaustive list, nor an endorsement of any technology described herein. Rather, this report is meant to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use. Information listed in this report is primarily vendor-provided; however, where possible it has been supplemented with additional information obtained from publications, reports, and websites. Manufacturers were given the chance to review summaries of their technologies from August through November 2013 to verify the accuracy of technical specifications, available references, and pricing.

  8. Genome-editing technologies and patent landscape overview.

    Science.gov (United States)

    Benahmed-Miniuk, Fairouz; Kresz, Mat; Kanaujiya, Jitendra K; Southgate, Christopher D

    2017-05-01

    Unlike with zinc finger nuclease and transcriptional activator-like effector nuclease DNA modification technologies that rely on lead proteins, developed through expensive and time-consuming processes, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system has rapidly emerged as the most promising gene-editing technology to date for the modification of any selected DNA sequence. CRISPR is receiving tremendous fanfare due, in part, to its potential to provide a means to fundamentally alter medical genetics and especially cancer medicine. In this review, we compare key technologies of genome-editing zinc finger nucleases, transcriptional activator-like effector nucleases and CRISPR, with a focus on the race to acquire lucrative intellectual property rights, the current CRISPR patent dispute and potential repercussions on innovation and the adoption of this promising technology by the medical community.

  9. 3rd August 2010 - CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt, signing the guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1008148 11: H. von Dewitz in the ATLAS Visitor centre with Collaboration member M. Hauschild (left) and Former IT Department Head W. von Rüden (right) CERN-HI-1008148 18 : Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid (left) in the ATLAS Visitor centre with Collaboration member M. Hauschild. CERN-HI-1008148: in the ATLAS visitor centre, from left to right: Former IT Department Head W. von Rüden; ATLAS Collaboration P. Mättig; CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt; Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid; H. von Dewitz; ATLAS Collaboration member M. Hauschild.

  10. 3rd International Conference on Nanotechnologies and Biomedical Engineering

    CERN Document Server

    Tiginyanu, Ion

    2016-01-01

    This volume presents the proceedings of the 3rd International Conference on Nanotechnologies and Biomedical Engineering which was held on September 23-26, 2015 in Chisinau, Republic of Moldova. ICNBME-2015 continues the series of International Conferences in the field of nanotechnologies and biomedical engineering. It aims at bringing together scientists and engineers dealing with fundamental and applied research for reporting on the latest theoretical developments and applications involved in the fields. Topics include Nanotechnologies and nanomaterials Plasmonics and metamaterials Bio-micro/nano technologies Biomaterials Biosensors and sensors systems Biomedical instrumentation Biomedical signal processing Biomedical imaging and image processing Molecular, cellular and tissue engineering Clinical engineering, health technology management and assessment; Health informatics, e-health and telemedicine Biomedical engineering education Nuclear and radiation safety and security Innovations and technology transfer...

  11. Diesel Technology: Engines. [Teacher and Student Editions.

    Science.gov (United States)

    Barbieri, Dave; Miller, Roger; Kellum, Mary

    Competency-based teacher and student materials on diesel engines are provided for a diesel technology curriculum. Seventeen units of instruction cover the following topics: introduction to engine principles and procedures; engine systems and components; fuel systems; engine diagnosis and maintenance. The materials are based on the…

  12. Electricity: Today's Technologies, Tomorrow's Alternatives. Revised Edition.

    Science.gov (United States)

    Electric Power Research Inst., Palo Alto, CA.

    This book traces the relatively new role of electricity in our energy history, discusses old and new ways of producing it (and related environmental issues), and closes with an agenda of technology-related issues that await decisions. Topics are presented in nine chapters. Chapters focus on (1) energy use; (2) energy demand; (3) energy supply; (4)…

  13. 3rd Developers@CERN Forum

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    It's about U and I !   The Developers@CERN Forum is an event by developers, for developers, aimed at promoting knowledge and experience sharing. This edition will take place at the IT Amphitheatre, on the 13th, 14th and 15th of February afternoons. It will consist of a series of short presentations and workshops. The topic for this conference will be Frontend & User interfaces. Have you got an idea for a presentation or workshop? Then, tell us about it (deadline on 27th of January). Registration will open in November. Please subscribe to developers-forum-announce@cern.ch mailing list for further information. This event will be made by developers for developers. We are counting on your presence, but also on your contributions! To learn more about the initiative, read the CERN Bulletin article. Organization You can get in touch us at developers-forum-organizers@cern.ch.

  14. Genome-editing Technologies for Gene and Cell Therapy.

    Science.gov (United States)

    Maeder, Morgan L; Gersbach, Charles A

    2016-03-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed.

  15. Genome-editing Technologies for Gene and Cell Therapy

    OpenAIRE

    Maeder, Morgan L; Gersbach, Charles A

    2016-01-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanis...

  16. Progress in Genome Editing Technology and Its Application in Plants

    OpenAIRE

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, pr...

  17. Newer Gene Editing Technologies toward HIV Gene Therapy

    Directory of Open Access Journals (Sweden)

    Premlata Shankar

    2013-11-01

    Full Text Available Despite the great success of highly active antiretroviral therapy (HAART in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called “Berlin patient” who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  18. BOOK REVIEW: Modern Physics, 3rd edn

    Science.gov (United States)

    Lovett, David

    1999-09-01

    The number of broadly based physics texts written at a level corresponding to second year and above of UK physics degrees is limited. This is such a book thoroughly updated in a third edition, the first edition having been published 20 years ago. The book is unusual in that the reader is referred to the Freeman website www.whfreeman.com/physics for some additional sections. It will be interesting to see whether this proves to be an attractive feature. The coverage reflects the US emphasis on topics and contains both theoretical and experimental details. It should not be regarded as an introductory text although it is clearly written. Thus the first two chapters take the reader straight into relativity, concentrating mainly on special relativity but going on to general relativity. From here the reader is led to ideas of quantization of charge, light and energy, followed by an exploration of the nuclear atom, wavelike properties of particles and Schrödinger's equation. Solution of this equation for the hydrogen atom introduces a section on spectroscopy. The next chapter on statistical physics includes Fermi-Dirac and Bose-Einstein statistics and brings to a close Part 1, which concentrates on the theoretical groundwork. Consistent with its title, the book does not cover traditional aspects of thermodynamics and electromagnetic theory. Part 2 is entitled `Applications' and begins with a chapter on molecular structure and spectra. Lasers and masers are included here but geometrical, physical and nonlinear optics get limited or no coverage. Solid state physics follows but, despite the title of the book, there is little on modern devices, although the section on superconductivity mentions high temperature materials. The chapters on nuclear physics, fission, fusion reactors and medical applications and a chapter on particle physics are comprehensive. Finally a chapter on astrophysics and cosmology is referred to, but the reader must find this at the website. As this is

  19. 3rd International Conference on Computational Mathematics and Computational Geometry

    CERN Document Server

    Ravindran, Anton

    2016-01-01

    This volume presents original research contributed to the 3rd Annual International Conference on Computational Mathematics and Computational Geometry (CMCGS 2014), organized and administered by Global Science and Technology Forum (GSTF). Computational Mathematics and Computational Geometry are closely related subjects, but are often studied by separate communities and published in different venues. This volume is unique in its combination of these topics. After the conference, which took place in Singapore, selected contributions chosen for this volume and peer-reviewed. The section on Computational Mathematics contains papers that are concerned with developing new and efficient numerical algorithms for mathematical sciences or scientific computing. They also cover analysis of such algorithms to assess accuracy and reliability. The parts of this project that are related to Computational Geometry aim to develop effective and efficient algorithms for geometrical applications such as representation and computati...

  20. 3rd Symposium on Space Optical Instruments and Applications

    CERN Document Server

    Zhang, Guangjun

    2017-01-01

    This volume contains selected and expanded contributions presented at the 3rd Symposium on Space Optical Instruments and Applications in Beijing, China June 28 – 29, 2016. This conference series is organised by the Sino-Holland Space Optical Instruments Laboratory, a cooperation platform between China and the Netherlands. The symposium focused on key technological problems of optical instruments and their applications in a space context. It covered the latest developments, experiments and results regarding theory, instrumentation and applications in space optics. The book is split across five topical sections. The first section covers space optical remote sensing system design, the second advanced optical system design, the third remote sensor calibration and measurement. Remote sensing data processing and information extraction is then presented, followed by a final section on remote sensing data applications. .

  1. Research progress of genome editing and derivative technologies in plants.

    Science.gov (United States)

    Shan, Qi-wei; Gao, Cai-xia

    2015-10-01

    Genome editing technologies using engineered nucleases have been widely used in many model organisms. Genome editing with sequence-specific nuclease (SSN) creates DNA double-strand breaks (DSBs) in the genomic target sites that are primarily repaired by the non-homologous end joining (NHEJ) or homologous recombination (HR) pathways, which can be employed to achieve targeted genome modifications such as gene mutations, insertions, replacements or chromosome rearrangements. There are three major SSNs─zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) system. In contrast to ZFN and TALEN, which require substantial protein engineering to each DNA target, the CRISPR/Cas9 system requires only a change in the guide RNA. For this reason, the CRISPR/Cas9 system is a simple, inexpensive and versatile tool for genome engineering. Furthermore, a modified version of the CRISPR/Cas9 system has been developed to recruit heterologous domains that can regulate endogenous gene expression, such as activation, depression and epigenetic regulation. In this review, we summarize the development and applications of genome editing technologies for basic research and biotechnology, as well as highlight challenges and future directions, with particular emphasis on plants.

  2. The EDIT school trains future experts in detector technologies

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    The Excellence in Detectors and Instrumentation Technologies (EDIT) School has just taken place for the first time. The enthusiastic feedback from the organizers and the participants shows how the School’s format is just the right formula for today’s young researchers specializing in experimental physics. To mark the importance of the event, Rolf Heuer dedicated the School to Georges Charpak.   Rolf Heuer and Pier Oddone visit Building 154, which hosted some of the EDIT School laboratory activities. Like many other branches of science, today’s particle physics relies on very complex instruments to provide the performance that unresolved questions require. When we say ‘particle physics’ we actually mean a whole lot of different specializations that young researchers choose to pursue when they are at university. “In the present situation, it might very well happen that an experimental particle physicist at the end of his/her studies has ne...

  3. 3rd Annual Workshop on Inverse Problem

    CERN Document Server

    2015-01-01

    This proceeding volume is based on papers presented on the Third Annual Workshop on Inverse Problems which was organized by the Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, and took place in May 2013 in Stockholm. The purpose of this workshop was to present new analytical developments and numerical techniques for solution of inverse problems for a wide range of applications in acoustics, electromagnetics, optical fibers, medical imaging, geophysics, etc. The contributions in this volume reflect these themes and will be beneficial to researchers who are working in the area of applied inverse problems.

  4. The 3rd DBCLS BioHackathon

    DEFF Research Database (Denmark)

    Katayama, Toshiaki; Wilkinson, Mark D; Micklem, Gos

    2013-01-01

    ABSTRACT: BACKGROUND: BioHackathon 2010 was the third in a series of meetings hosted by the Database Center for Life Sciences (DBCLS) in Tokyo, Japan. The overall goal of the BioHackathon series is to improve the quality and accessibility of life science research data on the Web by bringing...... for analysis and visualization. CONCLUSION: We provide a meeting report from BioHackathon 2010, in which we describe the discussions, decisions, and breakthroughs made as we moved towards compliance with Semantic Web technologies - from source provider, through middleware, to the end-consumer....

  5. 3rd International Conference of Serviceology

    CERN Document Server

    Spohrer, James; Kwan, Stephen; Takenaka, Takeshi

    2017-01-01

    Services are key activities in a globalized economy and they also underlie the quality of life of local residents. The advanced work presented in this book was selected from the proceedings of the Third International Conference on Serviceology (ICServ2015), held July 7–9, 2015, in San Jose, CA, USA. The conference was supported by the Society for Serviceology. The society was established in 2012 in Japan to explore the scientific systematization of services and to promote technological developments for solutions to industrial issues. This book provides a useful general guide to the state of the art in the theory and practice of services. It can also serve as a valuable reference book for researchers in a wide range of fields from engineering to marketing and economics.

  6. 3rd international conference, LDIC 2012

    CERN Document Server

    Scholz-Reiter, Bernd; Thoben, Klaus-Dieter

    2013-01-01

    The volume comprises the proceedings of the third International Conference on Dynamics in Logistics LDIC 2012. The scope of the conference targeted the identification, analysis, and description of the dynamics of logistic processes and networks. The spectrum ranged from the modeling and planning of processes and innovative methods like autonomous control and knowledge management to the new technologies provided by radio frequency identification, mobile communication, and networking. The growing dynamics in the area of logistics poses completely new challenges: Logistic processes and networks must rapidly and flexibly adapt to continuously changing conditions. LDIC 2012 provided a venue for researchers from academia and industry interested in the technical advances in dynamics in logistics. The conference addressed research in logistics from a wide range of fields, e.g. engineering, computer science and operations research. The volume consists of two invited papers and of 49 contributed papers divided into var...

  7. Control Robotics Programming Technology. Technology Learning Activity. Teacher Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This Technology Learning Activity (TLA) for control robotics programming technology in grades 6-10 is designed to teach students to construct and program computer-controlled devices using a LEGO DACTA set and computer interface and to help them understand how control technology and robotics affect them and their lifestyle. The suggested time for…

  8. Developing Product Lines with 3rd-party components

    NARCIS (Netherlands)

    De Jonge, M.

    2007-01-01

    The trends toward product line development and toward adopting more 3rd-party software are hard to combine. The reason is that productlines demand fine control over the software (e.g., for diversity management), while 3rd-party software (almost by definition) provides only little or no control. A

  9. 3rd International symposium on ambient intelligence

    CERN Document Server

    Tapia, Dante I; Novais, Paulo; ISAmI 2012; Ambient Intelligence : Software and Applications

    2012-01-01

    Ambient Intelligence (AmI) is a recent paradigm emerging from Artificial Intelligence (AI), where computers are used as proactive tools assisting people with their day-to-day activities, making everyone’s life more comfortable. Another main concern of AmI originates from the human computer interaction domain and focuses on offering ways to interact with systems in a more natural way by means user friendly interfaces. This field is evolving quickly as can be witnessed by the emerging natural language and gesture based types of interaction. The inclusion of computational power and communication technologies in everyday objects is growing and their embedding into our environments should be as invisible as possible. In order for AmI to be successful, human interaction with computing power and embedded systems in the surroundings should be smooth and happen without people actually noticing it. The only awareness people should have arises from AmI: more safety, comfort and wellbeing, emerging in a natural and inh...

  10. CRISPR/Cas9 technology for targeted genome editing

    Directory of Open Access Journals (Sweden)

    Lomov N. A.

    2015-08-01

    Full Text Available CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats are the segments of prokaryotic DNA containing short repeats in its nucleotide sequence. Today we know that this is a bacterial protection system against viral DNA. The molecular components of CRISPR/Cas9 system have been used for a gene editing in eukaryotes since 2013. But as any other method it also has the limitations and drawbacks. Here we are going to review the history of CRISPR biology and to discuss the possibilities that this new technology provides to researchers as well as the prospects for its use in the medical research and treatment.

  11. In vivo genome editing thrives with diversified CRISPR technologies

    Directory of Open Access Journals (Sweden)

    Xun Ma

    2018-03-01

    Full Text Available Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site-specific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies. These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research.

  12. The 3rd colloquium on process simulation. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Jokilaakso, A. [ed.

    1996-12-31

    The presentations collected in this volume were presented at the 3rd Colloquium on Process Simulation held at Helsinki University of Technology, Espoo, Finland, June 12-14, 1996. In the more developed industrial nations, the processes for producing chemicals, energy, and materials encounter environmental concern and laws which challenge engineers to develop the processes towards more efficient, economical and safe operation. This necessitates more thorough understanding of the processes and phenomena involved. Formerly, the development of the processes was largely based on trial and error, whereas today, the development of computer performance together with the diversification of modelling software enables simulation of the processes. The increased capacity and possibilities for modelling the processes brought by the improved hardware and software, have generated a strong demand for more accurate mathematical descriptions of the processes. Especially, the coupling of computational fluid dynamics and chemical kinetics, combustion, and thermodynamics is of current interest in process oriented technology. This colloquium attempts to give examples of modelling efforts in operation in different universities, research institutes and companies. Furthermore, the aim of this colloquium is to offer an annual opportunity to the researchers to come together and discuss their common problems and the state of their investigations

  13. Academic Training: 3rd Term - 01 April - 30 June 2005

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004 - 2005 ACADEMIC TRAINING PROGRAMME 3rd Term - 01 April - 30 June 2005 REGULAR LECTURE PROGRAMME Monte Carlo generators fot the LHC by T. Sjostrand / CERN-PH 4, 5, 6, 7 April The LHC machine experiment interface by S. Tapprogge / Univ. Gutenberg, Mainz, D R. Assmann, CERN-AB, E. Tsesmelis and D. Macina / CERN-TS 18, 19, 20, 21, 22 April Cosmology for particle physicists by S. Carroll / Univ. of Chicago, USA 9, 10, 11, 12, 13 May The ITER projects: technological challenges by P. Bruzzone / EPFL CRPP, Zürich, CH J. Lister / EPFL CRPP, Lausanne, CH 30, 31 May, 1, 2, 3 June String theory by C. Johnson / Univ. of Southern California, USA 6, 7, 8, 9, 10 June Small may be beautiful By M. Davier / LAL, Orsay, F. T. Soldner / ILL, Grenoble, F. 13, 14, 15, 16, 17 June Climate change and challenges for the environment by C. Schluchter / Univ. Bern. CH 20, 21, 22 June LECTURE SERIES FOR POSTGRADUATE STUDENTS Particle detectors - principles and techniques by C. Joram, L. Ropelewski, M. Moll, C. ...

  14. PREFACE: 3rd International Symposium ''Optics and its Applications''

    Science.gov (United States)

    Calvo, M. L.; Dolganova, I. N.; Gevorgyan, N.; Guzman, A.; Papoyan, A.; Sarkisyan, H.; Yurchenko, S.

    2016-01-01

    The SPIE.FOCUS Armenia: 3rd International Symposium ''Optics and its Applications'' (OPTICS-2015) http://rau.am/optics2015/ was held in Yerevan, Armenia, in the period October 1 - 5, 2015. The symposium was organized by the International Society for Optics and Photonics (SPIE), the Armenian SPIE student chapter with collaboration of the Armenian TC of ICO, the Russian-Armenian University (RAU), the Institute for Physical Research of National Academy of Sciences of Armenia (IPR of NAS), the Greek-Armenian industrial company LT-PYRKAL, and the Yerevan State University (YSU). The Symposium was co-organized by the SPIE & OSA student chapters of BMSTU, the Armenian OSA student chapter, and the SPIE student chapters of Lund University and Wroclaw University of Technology. The symposium OPTICS-2015 was dedicated to the International Year of Light and Light-Based Technologies. OPTICS-2015 was devoted to modern topics and optical technologies such as: optical properties of nanostructures, silicon photonics, quantum optics, singular optics & its applications, laser spectroscopy, strong field optics, biomedical optics, nonlinear & ultrafast optics, photonics & fiber optics, and mathematical methods in optics. OPTICS-2015 was attended by 100 scientists and students representing 17 countries: Armenia, China, Czech Republic, France, Georgia, Germany, India, Iran, Italy, Latvia, Mexico, Poland, Russia, Saudi Arabia, Sweden, Ukraine, and USA. Such a broad international community confirmed the important mission of science to be a uniting force between different countries, religions, and nations. We hope that OPTICS-2015 inspired and motivated students and young scientists to work in optics and in science in general. The present volume of Journal of Physics: Conference Series includes proceedings of the symposium covering various aspects of modern problems in optics. We are grateful to all people who were involved in the organization process. We gratefully acknowledge support from

  15. 3rd programme 'Energy research and energy technologies'

    International Nuclear Information System (INIS)

    1990-01-01

    In the light of developments in the 80s, the questions of dependence and available resources seem less grave in the long and medium term; on the other hand, a further problem has arisen which might prove even more serious with a view to the safeguarding of long-term energy supply: the use of fossil energy sources such as coal; petroleum, and natural gas involves effects constituting a considerable threat to the environment and the world climate. Examples are acid rain and the greenhouse effect. Furthermore, new safety issues and, to a larger extent, also acceptance issues have arisen as regards nuclear energy utilization. To contribute towards solving these problems by research and development is the main objective of this programme. The strategy adopted comprices two approaches complementary to each other: elaboration of scientific bases, system connections, and new techniques permitting - continued use of primary and secondary energy sources to the extent required while taking into account the needs of an increasingly more vulnerable environment; - to ensure the lowest possible energy consumption in the future, reducing, at the same time, considerably the amount of greenhouse gases emitted. (orig./UA) [de

  16. Current status and perspectives of genome editing technology for microalgae

    OpenAIRE

    Jeon, Seungjib; Lim, Jong-Min; Lee, Hyung-Gwan; Shin, Sung-Eun; Kang, Nam Kyu; Park, Youn-Il; Oh, Hee-Mock; Jeong, Won-Joong; Jeong, Byeong-ryool; Chang, Yong Keun

    2017-01-01

    Genome editing techniques are critical for manipulating genes not only to investigate their functions in biology but also to improve traits for genetic engineering in biotechnology. Genome editing has been greatly facilitated by engineered nucleases, dubbed molecular scissors, including zinc-finger nuclease (ZFN), TAL effector endonuclease (TALEN) and clustered regularly interspaced palindromic sequences (CRISPR)/Cas9. In particular, CRISPR/Cas9 has revolutionized genome editing fields with i...

  17. 3rd Active Flow and Combustion Control Conference

    CERN Document Server

    2015-01-01

    The book reports on the latest theoretical and experimental advances in the  field of active flow and combustion control. It covers new developments in actuator technology and sensing, in robust and optimal open- and closed-loop control, as well as in model reduction for control. It collects contributions presented during the third edition of the Active Flow and Combustion Control conference, held in September 10-12, 2014 at the Technische Universität Berlin (Germany). This conference, as well as the research presented in the book, have been supported by the collaborative research center SFB 1029 -Substantial efficiency increase in gas turbines through direct use of coupled unsteady combustion and flow dynamics, funded by the DFG (German Research Foundation).

  18. 3rd Session of the Sant Cugat Forum on Astrophysics

    CERN Document Server

    Gravitational wave astrophysics

    2015-01-01

    This book offers review chapters written by invited speakers of the 3rd Session of the Sant Cugat Forum on Astrophysics — Gravitational Waves Astrophysics. All chapters have been peer reviewed. The book goes beyond normal conference proceedings in that it provides a wide panorama of the astrophysics of gravitational waves and serves as a reference work for researchers in the field.

  19. Magnet Free Generators - 3rd Generation Wind Turbine Generators

    DEFF Research Database (Denmark)

    Jensen, Bogi Bech; Mijatovic, Nenad; Henriksen, Matthew Lee

    2013-01-01

    This paper presents an introduction to superconducting wind turbine generators, which are often referred to as 3rd generation wind turbine generators. Advantages and challenges of superconducting generators are presented with particular focus on possible weight and efficiency improvements. A comp....... A comparison of the rare earth usage in different topologies of permanent magnet generators and superconducting generators is also presented....

  20. 3rd Semester and Master’s Thesis Ideas 2013

    DEFF Research Database (Denmark)

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd...

  1. 3rd Semester and Master’s Thesis Ideas 2011

    DEFF Research Database (Denmark)

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...

  2. 3rd Semester and Master’s Thesis Ideas 2012

    DEFF Research Database (Denmark)

    Clausen, Johan

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...

  3. Hypertrophic cardiomyopathy presenting with 3rd-degree atrioventricular block.

    OpenAIRE

    Rosen, K L; Cameron, R W; Bigham, P J; Neish, S R

    1997-01-01

    A 15-year-old boy presented with exercise intolerance and near syncope. Electrocardiography showed 3rd-degree atrioventricular block. He was treated emergently with temporary transvenous ventricular pacing. Two-dimensional echocardiography revealed hypertrophic cardiomyopathy. Subsequently, a permanent, transvenous, dual-chamber pacemaker was implanted. Hypertrophic cardiomyopathy rarely causes complete atrioventricular block. It is particularly unusual for the presenting symptoms of hypertro...

  4. Global representatives flock to Stellenbosch for 3rd student affairs ...

    African Journals Online (AJOL)

    Global representatives flock to Stellenbosch for 3rd student affairs global summit. Thierry M. Luescher. Abstract. Media release, Division of Corporate Communication, Stellenbosch University, 28 October 2016. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  5. [The application of CRISPR/Cas9 genome editing technology in cancer research].

    Science.gov (United States)

    Wang, Da-yong; Ma, Ning; Hui, Yang; Gao, Xu

    2016-01-01

    The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease) genome editing technology has become more and more popular in gene editing because of its simple design and easy operation. Using the CRISPR/Cas9 system, researchers can perform site-directed genome modification at the base level. Moreover, it has been widely used in genome editing in multiple species and related cancer research. In this review, we summarize the application of the CRISPR/Cas9 system in cancer research based on the latest research progresses as well as our understanding of cancer research and genome editing techniques.

  6. New transgenic models of Parkinson's disease using genome editing technology.

    Science.gov (United States)

    Cota-Coronado, J A; Sandoval-Ávila, S; Gaytan-Dávila, Y P; Diaz, N F; Vega-Ruiz, B; Padilla-Camberos, E; Díaz-Martínez, N E

    2017-11-28

    Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta, which results in dopamine depletion, leading to a number of motor and non-motor symptoms. In recent years, the development of new animal models using nuclease-based genome-editing technology (ZFN, TALEN, and CRISPR/Cas9 nucleases) has enabled the introduction of custom-made modifications into the genome to replicate key features of PD, leading to significant advances in our understanding of the pathophysiology of the disease. We review the most recent studies on this new generation of in vitro and in vivo PD models, which replicate the most relevant symptoms of the disease and enable better understanding of the aetiology and mechanisms of PD. This may be helpful in the future development of effective treatments to halt or slow disease progression. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Progress in Genome Editing Technology and Its Application in Plants.

    Science.gov (United States)

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, protein-dependent DNA cleavage systems (i.e., zinc-finger nucleases, ZFN, and transcription activator-like effector nucleases, TALEN), RNA-dependent DNA cleavage systems (i.e., clustered regularly interspaced short palindromic repeats-CRISPR associated proteins, CRISPR-Cas9, CRISPR-Cpf1, and CRISPR-C2c1), and RNA-dependent RNA cleavage systems (i.e., RNA interference, RNAi, and CRISPR-C2c2). All these techniques can lead to double-stranded (DSB) or single-stranded breaks (SSB), and result in either random mutations via non-homologous end-joining (NHEJ) or targeted mutation via homologous recombination (HR). Thus, site-directed mutagenesis can be induced via targeted gene knock-out, knock-in, or replacement to modify specific characteristics including morphology-modification, resistance-enhancement, and physiological mechanism-improvement along with plant growth and development. In this paper, an non-comprehensive review on the development of different GETs as applied to plants is presented.

  8. Progress in Genome Editing Technology and Its Application in Plants

    Science.gov (United States)

    Zhang, Kai; Raboanatahiry, Nadia; Zhu, Bin; Li, Maoteng

    2017-01-01

    Genome editing technology (GET) is a versatile approach that has progressed rapidly as a mechanism to alter the genotype and phenotype of organisms. However, conventional genome modification using GET cannot satisfy current demand for high-efficiency and site-directed mutagenesis, retrofitting of artificial nucleases has developed into a new avenue within this field. Based on mechanisms to recognize target genes, newly-developed GETs can generally be subdivided into three cleavage systems, protein-dependent DNA cleavage systems (i.e., zinc-finger nucleases, ZFN, and transcription activator-like effector nucleases, TALEN), RNA-dependent DNA cleavage systems (i.e., clustered regularly interspaced short palindromic repeats-CRISPR associated proteins, CRISPR-Cas9, CRISPR-Cpf1, and CRISPR-C2c1), and RNA-dependent RNA cleavage systems (i.e., RNA interference, RNAi, and CRISPR-C2c2). All these techniques can lead to double-stranded (DSB) or single-stranded breaks (SSB), and result in either random mutations via non-homologous end-joining (NHEJ) or targeted mutation via homologous recombination (HR). Thus, site-directed mutagenesis can be induced via targeted gene knock-out, knock-in, or replacement to modify specific characteristics including morphology-modification, resistance-enhancement, and physiological mechanism-improvement along with plant growth and development. In this paper, an non-comprehensive review on the development of different GETs as applied to plants is presented. PMID:28261237

  9. PREFACE: 3rd International Congress on Ceramics (ICC3)

    Science.gov (United States)

    Niihara, Koichi; Ohji, Tatsuki; Sakka, Yoshio

    2011-10-01

    Early in 2005, the American Ceramic Society, the European Ceramic Society and the Ceramic Society of Japan announced a collaborative effort to provide leadership for the global ceramics community that would facilitate the use of ceramic and glass materials. That effort resulted in an agreement to organize a new biennial series of the International Congress on Ceramics, convened by the International Ceramic Federation (ICF). In order to share ideas and visions of the future for ceramic and glass materials, the 1st International Congress on Ceramics (ICC1) was held in Canada, 2006, under the organization of the American Ceramic Society, and the 2nd Congress (ICC2) was held in Italy, 2008, hosted by the European Ceramic Society. Organized by the Ceramic Society of Japan, the 3rd Congress (ICC3) was held in Osaka, Japan, 14-18 November 2010. Incorporating the 23rd Fall Meeting of the Ceramic Society of Japan and the 20th Iketani Conference, ICC3 was also co-organized by the Iketani Science and Technology Foundation, and was endorsed and supported by ICF, Asia-Oceania Ceramic Federation (AOCF) as well as many other organizations. Following the style of the previous two successful Congresses, the program was designed to advance ceramic and glass technologies to the next generation through discussion of the most recent advances and future perspectives, and to engage the worldwide ceramics community in a collective effort to expand the use of these materials in both conventional as well as new and exciting applications. ICC3 consisted of 22 voluntarily organized symposia in the most topical and essential themes of ceramic and glass materials, including Characterization, design and processing technologies Electro, magnetic and optical ceramics and devices Energy and environment related ceramics and systems Bio-ceramics and bio-technologies Ceramics for advanced industry and safety society Innovation in traditional ceramics It also contained the Plenary Session and the

  10. The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators.

    Science.gov (United States)

    Chakraborty, Chiranjib; Teoh, Seong Lin; Das, Srijit

    2017-01-01

    The present era is fast experiencing rapid innovation in the genome-editing technology. CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. The main objective of the present review is to highlight the structural signature, classification, its mechanism and application from basic science to medicine and future challenges for this genome editing tool kit. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We discuss the paradigms shift for this next generation genome editing technology, CRISPR. The CRISPR structural significance, classification and its different applications are also being discussed. We portray the future challenges for this extraordinary genome in vivo editing tool. We also highlight the role of CRISPR genome editing in curing many diseases. Scientists and researchers are constantly looking one genome editing tool that is competent, simple and low-cost assembly of nucleases. It can target any particular site without any off-target mutations in the genome. The CRISPR-Cas9 has all of the above characteristics. The genome engineering technology may be a strong and inspiring technology meant for the next generation of drug development. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  11. PREFACE: 3rd International Meeting on Silicene (IMS-3)

    Science.gov (United States)

    Kara, Abdelkader; Enriquez, Hanna; Lemaire, Jean Louis; Oughaddou, Hamid

    2014-03-01

    . Historical summary Every two years, the STARM (science, technologie avanc\\'ee et recherche pour la Mediterran\\'ee, http://www.starm.emcmre.org/) society is organizing an international conference entitled Euro-Mediterranean Conference on Materials and Renewable Energies (EMCMRE, http://www.emcmre.org/) in countries across the Mediterranean Sea. It is in this framework that an international meeting dedicated to silicene is organized simultaneously since 2010: 1st International Meeting of Silicene (IMS-1), Safi, Morocco, 2010 2nd International Meeting of Silicene (IMS-2), Marrakech, Morocco, 2011 3rd International Meeting of Silicene (IMS-3), Istres-Marseille, France, 2013 Conference pictures are available in the PDF

  12. Anatomy and Physiology. Module Set II: Major Body Systems. Teacher Edition [and] Student Edition. Surgical Technology.

    Science.gov (United States)

    Hilley, Robert

    This document, which is the second part of a two-part set of modules on anatomy and physiology for future surgical technicians, contains the teacher and student editions of an introduction to anatomy and physiology that consists of modules on the following body systems: integumentary system; skeletal system; muscular system; nervous system;…

  13. Technology Road-map - Nuclear Energy. 2015 edition

    International Nuclear Information System (INIS)

    Houssin, Didier; Dujardin, Thierry; Cameron, Ron; Tam, Cecilia; Paillere, Henri; Baroni, Marco; Bromhead, Amos; Baritaud, Manual; Cometto, Marco; Gaghen, Rebecca; Herzog, Antoine; Remme, Uwe; Urso, Maria-Elena; Vance, Robert

    2015-01-01

    Since the release in 2010 of Technology Road-map: Nuclear Energy (IEA/NEA, 2010), a number of events have had a significant impact on the global energy sector and on the outlook for nuclear energy. They include the Fukushima Daiichi nuclear power plant (NPP) accident in March 2011, the global financial and economic crises that hit many industrialised countries during the period 2008-10 and failings in both electricity and CO 2 markets. Despite these additional challenges, nuclear energy still remains a proven low-carbon source of base-load electricity, and many countries have reaffirmed the importance of nuclear energy within their countries' energy strategies. To achieve the goal of limiting global temperature increases to just 2 deg. C by the end of the century, a halving of global energy-related emissions by 2050 will be needed. A wide range of low-carbon energy technologies will be needed to support this transition, including nuclear energy. This edition of the nuclear road-map prepared jointly by the IEA and NEA take into account recent challenges facing the development of this technology. The 2015 edition of the Nuclear Energy Technology Road-map aims to: Outline the current status of nuclear technology development and the need for additional R and D to address increased safety requirements and improved economics. Provide an updated vision of the role that nuclear energy could play in a low-carbon energy system, taking into account changes in nuclear policy in various countries, as well as the current economics of nuclear and other low-carbon electricity technologies. Identify barriers and actions needed to accelerate the development of nuclear technologies to meet the Road-map vision. Share lessons learnt and good practices in nuclear safety and regulation, front- and back-end fuel cycle practices, construction, decommissioning, financing, training, capacity building and communication. Key findings: Nuclear power is the largest source of low

  14. 3rd International conference on social sciences & education research

    OpenAIRE

    ÇAM, Handan

    2017-01-01

    Abstract. The 3rd International Conference on Social Sciences & Education Research is an academic and scientific conference which was held  at Hotel Rome Pisana in Rome, Italy between April 27-29, 2017. ICSSER was organized by International Center of Social Science & Education Research, and hosted by Università degli Studi di Bergamo (Italy) and supported IJSSER-International Journal of Social Sciences & Education and JTTR-Journal of Tourism Theory and Research ICSSER has provided...

  15. 3rd International Multidisciplinary Microscopy and Microanalysis Congress

    CERN Document Server

    Oral, Zehra

    2017-01-01

    The 3rd International Multidisciplinary Microscopy Congress (InterM2015), held from 19 to 23 October 2015, focused on the latest developments concerning applications of microscopy in the biological, physical and chemical sciences at all dimensional scales, advances in instrumentation, techniques in and educational materials on microscopy. These proceedings gather 17 peer-reviewed technical papers submitted by leading academic and research institutions from nine countries and representing some of the most cutting-edge research available.

  16. Main operation results of the 3-rd generation nuclear fuel

    International Nuclear Information System (INIS)

    Adeev, V.; Saprykin, V.; Gagarinsky, A.

    2013-01-01

    On the Kola NPP, Unit 4 trial operation of the 3-rd generation fuel continues. This fuel have a number of design features, providing the best operational characteristics. Increasing of efficiency of nuclear fuel usage will be achieved by reduction of the parasitic capture of thermal neutrons in constructional materials (weight of zirconium is reduced), optimization of uranium water relation (increase in fuel elements step), increasing of uranium loading (usage of fuel pallets with increased diameter and without central hole in them). The basic characteristics of the core with fuel of the 3rd generation are provided in work [3]. In the present report, being addition to the report [4], gave new results of operation and the short analysis of the obtained data is made. Experimental characteristics of WWER-440 reactor core with fuel assemblies of the 2nd (FA-2) and 3rd (FA-3) generation of the enrichment increased to 4.87% are submitted. Some questions of operation of FA-2 and FA-3 are discussed: assessment of influence of cover absence on indications of thermocouples at joint operation of FA-2 and FA-3, features and methods of core design. (authors)

  17. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Zachara, J.; Lulinski, S.; Dobrowolski, J.C.; Raczynska, E.D.; Fuks, L.; Cyranski, M.K.; Stepien, B.T.; Sawicki, M.G.

    2006-01-01

    3 rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  18. The 3rd Sino-Japan nuclear medicine conference

    International Nuclear Information System (INIS)

    1999-01-01

    The 3rd Sino-Japan Nuclear Medicine Conference was hold on May 11-13, 1999 in Xi'an of China by Chinese Society of Nuclear Medicine, Japanese Society of Nuclear Medicine, Chinese Medicine Association and Japan-China Medicine Association. 62 articles were published in the proceeding of the conference. The contents of the articles include development and application of the radioisotopes (such as Tc-99, I-125, I-131, F-18, In-111, Tl-201, Ga-67, Sm-153, Re-188) and its radiopharmaceuticals, but application also include radiotherapy and diagnosis in the oncology and pathology by SPECT and PET

  19. 3rd International Conference on Movement, Health and Exercise 2016

    CERN Document Server

    Cheong, Jadeera; Usman, Juliana; Ahmad, Mohd; Razman, Rizal; Selvanayagam, Victor

    2017-01-01

    This volume presents the proceedings of the 3rd International Conference on Movement, Health and Exercise 2016 (MoHE2016). The conference was jointly organized by the Biomedical Engineering Department and Sports Centre, University of Malaya. It was held in Malacca, from 28-30 September 2016. MoHE 2016 provided a good opportunity for speakers and participants to actively discuss about recent developments in a wide range of topics in the area of sports and exercise science. In total, 83 presenters and 140 participants took part in this successful conference. .

  20. Proceedings of the 3rd Symposium on Engineering Sciences

    International Nuclear Information System (INIS)

    Ahmed, J.; Rizvi, S.Z.H.; Ahmad, R.; Saleem, M.

    2010-01-01

    The 3rd symposium on engineering sciences was held from March 10-12, 2010 in Lahore, Pakistan. More than twenty academic institutions and six industries participated in this conference. The foreign and Pakistani experts delivered their keynotes talk, contributor lectures and poster presentation on the conference topics. In three days of the symposium, Fifty four papers presented on different topics of Engineering Sciences including chemical engineering, energy engineering, metallurgy engineering, material engineering and electrical engineering. This symposium provided an ideal opportunity for exchange of information amongst scientists, engineers and researchers from all over Pakistan and other countries of the world. (A.B)

  1. 3rd Workshop on "Combinations of Intelligent Methods and Applications"

    CERN Document Server

    Palade, Vasile

    2013-01-01

    The combination of different intelligent methods is a very active research area in Artificial Intelligence (AI). The aim is to create integrated or hybrid methods that benefit from each of their components.  The 3rd Workshop on “Combinations of Intelligent Methods and Applications” (CIMA 2012) was intended to become a forum for exchanging experience and ideas among researchers and practitioners who are dealing with combining intelligent methods either based on first principles or in the context of specific applications. CIMA 2012 was held in conjunction with the 22nd European Conference on Artificial Intelligence (ECAI 2012).This volume includes revised versions of the papers presented at CIMA 2012.  .

  2. Application and development of genome editing technologies to the Solanaceae plants.

    Science.gov (United States)

    Yamamoto, Tsuyoshi; Kashojiya, Sachiko; Kamimura, Saori; Kameyama, Takato; Ariizumi, Tohru; Ezura, Hiroshi; Miura, Kenji

    2018-03-02

    Genome editing technology using artificial nucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regulatory interspaced short palindromic repeats (CRISPR)-Cas9, can mutagenize the target sites of genes of interest. This technology has been successfully applied in several crops, including the Solanaceae plants, such as tomato, potato, tobacco, and petunia. Among the three nucleases, CRISPR-Cas9 is the best for breeding, crop improvement, and the functional analysis of genes of interest, because of its simplicity and high efficiency. Although the technology is useful for reverse genetics, its use in plants is limited due to a lack of regeneration protocols and sequence information. In this review, the present status of genome editing technology in Solanaceae plants is described, and techniques that may improve genome editing technologies are discussed. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  3. 2015 Edition Health Information Technology (Health IT) Certification Criteria, 2015 Edition Base Electronic Health Record (EHR) Definition, and ONC Health IT Certification Program Modifications. Final rule.

    Science.gov (United States)

    2015-10-16

    This final rule finalizes a new edition of certification criteria (the 2015 Edition health IT certification criteria or "2015 Edition'') and a new 2015 Edition Base Electronic Health Record (EHR) definition, while also modifying the ONC Health IT Certification Program to make it open and accessible to more types of health IT and health IT that supports various care and practice settings. The 2015 Edition establishes the capabilities and specifies the related standards and implementation specifications that Certified Electronic Health Record Technology (CEHRT) would need to include to, at a minimum, support the achievement of meaningful use by eligible professionals (EPs), eligible hospitals, and critical access hospitals (CAHs) under the Medicare and Medicaid EHR Incentive Programs (EHR Incentive Programs) when such edition is required for use under these programs.

  4. 3rd International Conference on X-ray Technique

    Science.gov (United States)

    Potrakhov, N. N.; Gryaznov, A. Yu; Lisenkov, A. A.; Kostrin, D. K.

    2017-02-01

    In this preface a brief history, modern aspects and future tendencies in development of the X-ray technique as seen from the 3rd International Conference on X-ray Technique that was held on 24-25 November 2016 in Saint Petersburg, Russia are described On 24-25 November 2016 in Saint Petersburg on the basis of Saint Petersburg State Electrotechnical University “LETI” n. a. V. I. Ulyanov (Lenin) was held the 3rd International Conference on X-ray Technique. The tradition to hold a similar conference in our country was laid in Soviet times. The last of them, the All-Union Conference on the Prospects of X-ray Tubes and Equipment was organized and held more than a quarter century ago - on 21-23 November 1999, at the initiative and under the leadership of the chief engineer of the Leningrad association of electronic industry “Svetlana” Borovsky Alexander Ivanovich and the chief of special design bureau of X-ray devices of “Svetlana” Shchukin Gennady Anatolievich. The most active part in the organization and work of the conference played members of the department of X-ray and electron beam instruments of Leningrad Electrotechnical Institute “LETI” (the former name of Saint Petersburg State Electrotechnical University “LETI”), represented by head of the department professor Ivanov Stanislav Alekseevich.

  5. Microstructure Modeling of 3rd Generation Disk Alloys

    Science.gov (United States)

    Jou, Herng-Jeng

    2010-01-01

    The objective of this program is to model, validate, and predict the precipitation microstructure evolution, using PrecipiCalc (QuesTek Innovations LLC) software, for 3rd generation Ni-based gas turbine disc superalloys during processing and service, with a set of logical and consistent experiments and characterizations. Furthermore, within this program, the originally research-oriented microstructure simulation tool will be further improved and implemented to be a useful and user-friendly engineering tool. In this report, the key accomplishment achieved during the second year (2008) of the program is summarized. The activities of this year include final selection of multicomponent thermodynamics and mobility databases, precipitate surface energy determination from nucleation experiment, multiscale comparison of predicted versus measured intragrain precipitation microstructure in quench samples showing good agreement, isothermal coarsening experiment and interaction of grain boundary and intergrain precipitates, primary microstructure of subsolvus treatment, and finally the software implementation plan for the third year of the project. In the following year, the calibrated models and simulation tools will be validated against an independently developed experimental data set, with actual disc heat treatment process conditions. Furthermore, software integration and implementation will be developed to provide material engineers valuable information in order to optimize the processing of the 3rd generation gas turbine disc alloys.

  6. Genome Editing During Development Using the CRISPR-Cas Technology.

    Science.gov (United States)

    Arzate-Mejía, Rodrigo G; Licona-Limón, Paula; Recillas-Targa, Félix

    2018-01-01

    Over the years, the study of gene function during development involved the implementation of sophisticated transgenic strategies to visualize how organisms change during their lifetime. These strategies are diverse and extremely useful and allowed the discovery of some of the fundamental mechanisms governing organism's development. Such strategies can be time-consuming, in some cases expensive, and require complex infrastructure. With the advent of the genome editing CRISPR-Cas9 RNA-guided DNA endonuclease system a tremendous progress has been achieved in manipulating diverse organisms and cell types. In recent years this system has contributed importantly to the design of novel experimental strategies to further understand developmental processes, to generate genetically modified animal models, and develop disease models. Here we highlight examples in which the genome editing CRISPR-Cas9 system has been employed to understand the mechanisms controlling embryonic development and disease.

  7. 3rd Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2014-01-01

    This book is based on the research papers presented in the 3rd Computer Science On-line Conference 2014 (CSOC 2014).   The conference is intended to provide an international forum for discussions on the latest high-quality research results in all areas related to Computer Science. The topics addressed are the theoretical aspects and applications of Artificial Intelligences, Computer Science, Informatics and Software Engineering.   The authors provide new approaches and methods to real-world problems, and in particular, exploratory research that describes novel approaches in their field. Particular emphasis is laid on modern trends in selected fields of interest. New algorithms or methods in a variety of fields are also presented.   This book is divided into three sections and covers topics including Artificial Intelligence, Computer Science and Software Engineering. Each section consists of new theoretical contributions and applications which can be used for the further development of knowledge of everybod...

  8. The 3rd International Conference on Solid State Chemistry. Preface

    International Nuclear Information System (INIS)

    The 3 rd International Conference on Solid State Chemistry took place on 6-12 July 1996 in Bratislava, Slovakia, under the auspices of the Presidium of the Slovak Academy of Sciences. In the conference participated 158 scientists from many countries of the world. The conference covered all aspects of modern solid state chemistry and the presentation of papers was divided into eight sections consisting of invited lectures and oral as well as poster presentations. The individual sections were devoted to the high-temperature ceramic superconductors, the layered compounds, clathrates and intercalates, the oxide and non-oxide glasses, the structure and properties of solids, the electron structure and chemical bonding in solids, the surface chemistry of solids, the solid state superionic, and to the local structure and bonding cementitious binding materials. (authors)

  9. 3rd International Workshop on Turbulent Spray Combustion

    CERN Document Server

    Gutheil, Eva

    2014-01-01

    This book reflects the results of the 2nd and 3rd International Workshops on Turbulent Spray Combustion. The focus is on progress in experiments and numerical simulations for two-phase flows, with emphasis on spray combustion. Knowledge of the dominant phenomena and their interactions allows development of predictive models and their use in combustor and gas turbine design. Experts and young researchers present the state-of-the-art results, report on the latest developments and exchange ideas in the areas of experiments, modelling and simulation of reactive multiphase flows. The first chapter reflects on flame structure, auto-ignition and atomization with reference to well-characterized burners, to be implemented by modellers with relative ease. The second chapter presents an overview of first simulation results on target test cases, developed at the occasion of the 1st International Workshop on Turbulent Spray Combustion. In the third chapter, evaporation rate modelling aspects are covered, while the fourth ...

  10. 3rd Workshop on Branching Processes and their Applications

    CERN Document Server

    González, Miguel; Gutiérrez, Cristina; Martínez, Rodrigo; Minuesa, Carmen; Molina, Manuel; Mota, Manuel; Ramos, Alfonso; WBPA15

    2016-01-01

    This volume gathers papers originally presented at the 3rd Workshop on Branching Processes and their Applications (WBPA15), which was held from 7 to 10 April 2015 in Badajoz, Spain (http://branching.unex.es/wbpa15/index.htm). The papers address a broad range of theoretical and practical aspects of branching process theory. Further, they amply demonstrate that the theoretical research in this area remains vital and topical, as well as the relevance of branching concepts in the development of theoretical approaches to solving new problems in applied fields such as Epidemiology, Biology, Genetics, and, of course, Population Dynamics. The topics covered can broadly be classified into the following areas: 1. Coalescent Branching Processes 2. Branching Random Walks 3. Population Growth Models in Varying and Random Environments 4. Size/Density/Resource-Dependent Branching Models 5. Age-Dependent Branching Models 6. Special Branching Models 7. Applications in Epidemiology 8. Applications in Biology and Genetics Offer...

  11. 3rd grade English language learners making sense of sound

    Science.gov (United States)

    Suarez, Enrique; Otero, Valerie

    2013-01-01

    Despite the extensive body of research that supports scientific inquiry and argumentation as cornerstones of physics learning, these strategies continue to be virtually absent in most classrooms, especially those that involve students who are learning English as a second language. This study presents results from an investigation of 3rd grade students' discourse about how length and tension affect the sound produced by a string. These students came from a variety of language backgrounds, and all were learning English as a second language. Our results demonstrate varying levels, and uses, of experiential, imaginative, and mechanistic reasoning strategies. Using specific examples from students' discourse, we will demonstrate some of the productive aspects of working within multiple language frameworks for making sense of physics. Conjectures will be made about how to utilize physics as a context for English Language Learners to further conceptual understanding, while developing their competence in the English language.

  12. 3rd International Symposium for Intelligent Transportation and Smart City

    CERN Document Server

    Xie, Xiongyao; Sun, Jian; Ma, Limin; Chen, Yinong; ITASC

    2017-01-01

    This book presents research advances in intelligent transportation and smart cities in detail, mainly focusing on green traffic and urban utility tunnels, presented at the 3rd International Symposium for Intelligent Transportation and Smart City (ITASC) held at Tongji University, Shanghai, on May 19–20, 2017. It discusses a number of hot topics, such as the 2BMW system (Bus, Bike, Metro and Walking), transportation safety and environmental protection, urban utility design and application, as well as the application of BIM (Building Information Modeling) in city design. By connecting the theory and applications of intelligent transportation in smart cities, it enhances traffic efficiency and quality. The book gathers numerous selected papers and lectures, including contributions from respected scholars and the latest engineering advances, to provide guidance to researchers in the field of transportation and urban planning at universities and in related industries. The first conference in the ITASC series sta...

  13. Organizational Knowledge Communication – a Nascent 3rd Order Disciplinarity

    DEFF Research Database (Denmark)

    Kastberg, Peter

    2014-01-01

    disciplinarity. Whereas each discipline is a strand in its own right in the helix, these strands, nevertheless, also allow for disciplinary integration, albeit punctually and dynamically. And it is exactly in such trilateral punctual and dynamic integrations that Organizational Knowledge Communication becomes...... visible, becomes a disciplinarity. I theoretically present an example of such a punctual integration and point to some of the immediate research promises that it holds. This theoretical account ends by describing Organizational Knowledge Communication as a nascent 3rd order disciplinarity.......There is an emerging tendency that the organizational communication functions of larger companies enter into a symbiotic relationship with the companies’ Knowledge Management function. A tendency this journal has labelled Organizational Knowledge Communication. This should come as no surprise...

  14. Power Amplifier Linearization Techniques for 3rd Generation Handsets

    DEFF Research Database (Denmark)

    Nielsen, Troels Studsgaard

    Bm drive level and within a load VSWR of 5:1, measured and simulated adjacent channel power ratios deviates less than 2dB. Based on the model and a system simulator implementation of the linearizer, three system level studies are performed. A study of the polynomial workfunction composition reveals......Linearization is a systematic method for reducing an amplifier’s distortion. By distortion reduction, the linearizer allows the amplifier to produce more output power and thereby to operate at a higher level of efficiency for a given level of distortion. There exist a number of different Power...... Amplifier (PA) linearization techniques. These range from adding just a few extra components to the conventional amplifier design to complete and very complex transmitter designs. This dissertation deals with PA linearization techniques suitable for 3rd generation cellular handsets. In particular, focus...

  15. Application of genome editing technologies to the study and treatment of hematological disease.

    Science.gov (United States)

    Pellagatti, Andrea; Dolatshad, Hamid; Yip, Bon Ham; Valletta, Simona; Boultwood, Jacqueline

    2016-01-01

    Genome editing technologies have advanced significantly over the past few years, providing a fast and effective tool to precisely manipulate the genome at specific locations. The three commonly used genome editing technologies are Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Cas9 (CRISPR/Cas9) system. ZFNs and TALENs consist of endonucleases fused to a DNA-binding domain, while the CRISPR/Cas9 system uses guide RNAs to target the bacterial Cas9 endonuclease to the desired genomic location. The double-strand breaks made by these endonucleases are repaired in the cells either by non-homologous end joining, resulting in the introduction of insertions/deletions, or, if a repair template is provided, by homology directed repair. The ZFNs, TALENs and CRISPR/Cas9 systems take advantage of these repair mechanisms for targeted genome modification and have been successfully used to manipulate the genome in human cells. These genome editing tools can be used to investigate gene function, to discover new therapeutic targets, and to develop disease models. Moreover, these genome editing technologies have great potential in gene therapy. Here, we review the latest advances in the application of genome editing technology to the study and treatment of hematological disorders. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. A technological and regulatory outlook on CRISPR crop editing.

    Science.gov (United States)

    Globus, Rea; Qimron, Udi

    2018-02-01

    Generating plants with increased yields while maintaining low production and maintenance costs is highly important since plants are the major food source for humans and animals, as well as important producers of chemicals, pharmaceuticals, and fuels. Gene editing approaches, particularly the CRISPR-Cas system, are the preferred methods for improving crops, enabling quick, robust, and accurate gene manipulation. Nevertheless, new breeds of genetically modified crops have initiated substantial debates concerning their biosafety, commercial use, and regulation. Here, we discuss the challenges facing genetic engineering of crops by CRISPR-cas, and highlight the pros and cons of using this tool. © 2017 Wiley Periodicals, Inc.

  17. Intelligent Technologies for Interactive Entertainment

    NARCIS (Netherlands)

    Nijholt, Antinus; Reidsma, Dennis; Hondorp, G.H.W.; Unknown, [Unknown

    2009-01-01

    These are the proceedings of the 3rd International Conference on Intelligent Technologies for Interactive Entertainment (INTETAIN 09). The first edition of this conference, organised in Madonna di Campiglio, saw the gathering of a diverse audience with broad and varied interests. With presentations

  18. CRISPR Editing Technology in Biological and Biomedical Investigation.

    Science.gov (United States)

    White, Martyn K; Kaminski, Rafal; Young, Won-Bin; Roehm, Pamela C; Khalili, Kamel

    2017-11-01

    The CRISPR or clustered regularly interspaced short palindromic repeats system is currently the most advanced approach to genome editing and is notable for providing an unprecedented degree of specificity, effectiveness, and versatility in genetic manipulation. CRISPR evolved as a prokaryotic immune system to provide an acquired immunity and resistance to foreign genetic elements such as bacteriophages. It has recently been developed into a tool for the specific targeting of nucleotide sequences within complex eukaryotic genomes for the purpose of genetic manipulation. The power of CRISPR lies in its simplicity and ease of use, its flexibility to be targeted to any given nucleotide sequence by the choice of an easily synthesized guide RNA, and its ready ability to continue to undergo technical improvements. Applications for CRISPR are numerous including creation of novel transgenic cell animals for research, high-throughput screening of gene function, potential clinical gene therapy, and nongene-editing approaches such as modulating gene activity and fluorescent tagging. In this prospect article, we will describe the salient features of the CRISPR system with an emphasis on important drawbacks and considerations with respect to eliminating off-target events and obtaining efficient CRISPR delivery. We will discuss recent technical developments to the system and we will illustrate some of the most recent applications with an emphasis on approaches to eliminate human viruses including HIV-1, JCV and HSV-1 and prospects for the future. J. Cell. Biochem. 118: 3586-3594, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  19. Genome-editing technologies and their potential application in horticultural crop breeding

    Science.gov (United States)

    Xiong, Jin-Song; Ding, Jing; Li, Yi

    2015-01-01

    Plant breeding, one of the oldest agricultural activities, parallels human civilization. Many crops have been domesticated to satisfy human's food and aesthetical needs, including numerous specialty horticultural crops such as fruits, vegetables, ornamental flowers, shrubs, and trees. Crop varieties originated through selection during early human civilization. Other technologies, such as various forms of hybridization, mutation, and transgenics, have also been invented and applied to crop breeding over the past centuries. The progress made in these breeding technologies, especially the modern biotechnology-based breeding technologies, has had a great impact on crop breeding as well as on our lives. Here, we first review the developmental process and applications of these technologies in horticultural crop breeding. Then, we mainly describe the principles of the latest genome-editing technologies and discuss their potential applications in the genetic improvement of horticultural crops. The advantages and challenges of genome-editing technologies in horticultural crop breeding are also discussed. PMID:26504570

  20. 3rd Joint Dutch-Brazil School on Theoretical Physics

    CERN Document Server

    2015-01-01

    The Joint Dutch-Brazil School on Theoretical Physics is now in its third edition with previous schools in 2007 and 2011. This edition of the school will feature minicourses by Nima Arkani-Hamed (IAS Princeton), Jan de Boer (University of Amsterdam) and Cumrun Vafa (Harvard University), as well as student presentations. The school is jointly organized with the Dutch Research School of Theoretical Physics (DRSTP) and is intended for graduate students and researchers in the field of high-energy theoretical physics. There is no registration fee and limited funds are available for local and travel support of participants. This school in São Paulo will be preceded by the XVIII J. A. Swieca School in Campos de Jordão.

  1. PREFACE: 3rd Workshop on Theory, Modelling and Computational Methods for Semiconductors (TMCSIII)

    Science.gov (United States)

    Califano, Marco; Migliorato, Max; Probert, Matt

    2012-05-01

    These conference proceedings contain the written papers of the contributions presented at the 3rd International Conference on Theory, Modelling and Computational Methods for Semiconductor materials and nanostructures. The conference was held at the School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK on 18-20 January 2012. The previous conferences in this series took place in 2010 at St William's College, York and in 2008 at the University of Manchester, UK. The development of high-speed computer architectures is finally allowing the routine use of accurate methods for calculating the structural, thermodynamic, vibrational, optical and electronic properties of semiconductors and their hetero- and nano-structures. The scope of this conference embraces modelling, theory and the use of sophisticated computational tools in semiconductor science and technology, where there is substantial potential for time-saving in R&D. Theoretical approaches represented in this meeting included: Density Functional Theory, Tight Binding, Semiempirical Pseudopotential Methods, Effective Mass Models, Empirical Potential Methods and Multiscale Approaches. Topics included, but were not limited to: Optical and Transport Properties of Quantum Nanostructures including Colloids and Nanotubes, Plasmonics, Magnetic Semiconductors, Graphene, Lasers, Photonic Structures, Photovoltaic and Electronic Devices. This workshop ran for three days, with the objective of bringing together UK and international leading experts in the theoretical modelling of Group IV, III-V and II-VI semiconductors, as well as students, postdocs and early-career researchers. The first day focused on providing an introduction and overview of this vast field, aimed particularly at students, with several lectures given by recognised experts in various theoretical approaches. The following two days showcased some of the best theoretical research carried out in the UK in this field, with several

  2. Diesel Technology: Electrical and Electronic Systems. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Ready, Allan; Kauffman, Ricky; Bogle, Jerry

    This document contains the materials for a competency-based course in diesel technology and electrical and electronic systems that is tied to measurable and observable learning outcomes identified and validated by an advisory committee of business and industry representatives and teachers. The competencies addressed align with the medium/heavy…

  3. 3rd Course of the International School of Advanced Geodesy

    CERN Document Server

    Sansò, Fernando

    1985-01-01

    During the period April 25th to May 10th, 1984 the 3rd Course of the International School of Advanced Geodesy entitled "Optimization and Design of Geodetic Networks" took place in Erice. The main subject of the course is clear from the title and consisted mainly of that particular branch of network analysis, which results from applying general concepts of mathematical optimization to the design of geodetic networks. As al­ ways when dealing with optimization problems, there is an a-priori choice of the risk (or gain) function which should be minimized (or maximized) according to the specific interest of the "designer", which might be either of a scientific or of an economic nature or even of both. These aspects have been reviewed in an intro­ ductory lecture in which the particular needs arising in a geodetic context and their analytical representations are examined. Subsequently the main body of the optimization problem, which has been conven­ tionally divided into zero, first, second and third order desi...

  4. Development of the 3rd Generation ECR ion source

    International Nuclear Information System (INIS)

    Lyneis, C.M.; Xie, Z.Q.; Taylor, C.E.

    1997-09-01

    The LBNL 3rd Generation ECR ion source has progressed from a concept to the fabrication of a full scale prototype superconducting magnet structure. This new ECR ion source will combine the recent ECR ion source techniques that significantly enhance the production of high charge state ions. The design includes a plasma chamber made from aluminum to provide additional cold electrons, three separate microwave feeds to allow multiple-frequency plasma heating (at 10, 14 and 18 GHz or at 6, 10 and 14 GHz) and very high magnetic mirror fields. The design calls for mirror fields of 4 T at injection and 3 T at extraction and for a radial field strength at the wall of 2.4 T. The prototype superconducting magnet structure which consists of three solenoid coils and six race track coils with iron poles forming the sextupole has been tested in a vertical dewar. After training, the sextupole magnet reached 105% of its design current with the solenoids off. With the solenoids operating at approximately 70% of their full design field, the sextuple coils operated at 95% of the design value which corresponds to a sextupole field strength at the plasma wall of more than 2.1 T

  5. Clinician's guide to assessing and counseling older drivers, 3rd Edition.

    Science.gov (United States)

    2015-01-01

    The American Geriatrics Society (AGS) entered into a cooperative agreement with the U. S . : Department of Transportations National Highway Traffic Safety Administration (NHTSA) to : update and expand the Physicians Guide to Assessing and Couns...

  6. An introduction to Kolmogorov complexity and its applications. - 3rd edition

    NARCIS (Netherlands)

    Li, M.; Vitányi, P.

    2008-01-01

    Written by two experts in the field, this book is ideal for advanced undergraduate students, graduate students, and researchers in all fields of science. It is self-contained: it contains the basic requirements from mathematics, probability theory, statistics, information theory, and computer

  7. Gavel to Gavel: A Guide to the Televised Proceedings of Congress. 3rd Edition.

    Science.gov (United States)

    Green, Alan

    C-SPAN is a non-profit public service television network created by the U.S. cable television industry to provide viewers live gavel-to-gavel access to the proceedings of the U.S. House of Representatives and the U.S. Senate, and to other forums where public policy is discussed, debated, and decided. This guide presents a brief history of how…

  8. Principles and Applications of Imaging Radar, Manual of Remote Sensing, 3rd Edition, Volume 2

    Science.gov (United States)

    Moran, M. Susan

    Aerial photographs and digital images from orbiting optical scanners are a daily source of information for the general public through newspapers, television, magazines, and posters. Such images are just as prevalent in scientific journal literature. In the last 6 months, more than half of the weekly issues of Eos published an image acquired by a remote digital sensor. As a result, most geoscientists are familiar with the characteristics and even the acronyms of the current satellites and their optical sensors, common detector filters, and image presentation. In many cases, this familiarity has bred contempt. This is so because the limitations of optical sensors (imaging in the visible and infrared portions of the electromagnetic spectrum) can be quite formidable. Images of the surface cannot be acquired through clouds, and image quality is impaired with low-light conditions (such as at polar regions), atmospheric scattering and absorption, and variations in sun/sensor/surface geometry.

  9. The Press and America: An Interpretative History of the Mass Media. 3rd Edition.

    Science.gov (United States)

    Emery, Edwin

    This book presents a history of journalism in the United States. The opening chapters discuss the European roots of American journalism and cover the time-span ending with the Civil War; the primary concern is an exposition of the principles of the American press. The remaining chapters examine the mass media--newspapers, television, radio,…

  10. Kids at Hope: Every Child Can Succeed, No Exceptions! 3rd Edition

    Science.gov (United States)

    Carlos, John P.; Miller, Rick

    2010-01-01

    "Kids at Hope" inspires, empowers, and transforms families, youth serving organizations and entire communities to create an environment where all children experience success. This book contains the following chapters: (1) The Visit Universal Truths I & II; (2) The Classroom (A Celebration of Success); (3) What Makes a Difference?; (4) No…

  11. Reading Improvement through Art Replicator Manual of Instruction, 3rd Edition

    Science.gov (United States)

    Corwin, Sylvia K., Ed.

    2013-01-01

    Reading Improvement Through Art (RITA) program is an interdisciplinary approach to literacy that blends visual art with reading comprehension, evaluated in nine New York City urban high schools. 240 problem readers participating in the pilot program were pre- and post-tested in the Fall 1975 and Spring 1976 semesters. The testing showed the 9th…

  12. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Czech Academy of Sciences Publication Activity Database

    Váchová, Libuše

    2016-01-01

    Roč. 12, č. 1 (2016), s. 1-222 ISSN 1554-8627 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0109; GA MŠk(CZ) LD15129 Institutional support: RVO:61388971 Keywords : autolysosome * autophagosome * chaperone-mediated autophagy Subject RIV: EE - Microbiology, Virology Impact factor: 8.593, year: 2016

  13. PREFACE: 3rd International Conference of Mechanical Engineering Research (ICMER 2015)

    Science.gov (United States)

    Mamat, Riazalman; Rahman, Mustafizur; Mohd. Zuki Nik Mohamed, Nik; Che Ghani, Saiful Anwar; Harun, Wan Sharuzi Wan

    2015-12-01

    The 3rd ICMER2015 is the continuity of the NCMER2010. The year 2010 represents a significant milestone in the history for Faculty of Mechanical Engineering, Universiti Malaysia Pahang (UMP) Malaysia with the organization of the first and second national level conferences (1st and 2nd NCMER) at UMP on May 26-27 and Dec 3-4 2010. The Faculty then changed the name from National Conference on Mechanical Engineering Research (NCMER) to International Conference on Mechanical Engineering Research (ICMER) in 2011 and this year, 2015 is our 3rd ICMER. These proceedings contain the selected scientific manuscripts submitted to the conference. It is with great pleasure to welcome you to the "International Conference on Mechanical Engineering Research (ICMER2015)" that is held at Zenith Hotel, Kuantan, Malaysia. The call for papers attracted submissions of over two hundred abstracts from twelve different countries including Japan, Iran, China, Kuwait, Indonesia, Norway, Philippines, Morocco, Germany, UAE and more. The scientific papers published in these proceedings have been revised and approved by the technical committee of the 3rd ICMER2015. All of the papers exhibit clear, concise, and precise expositions that appeal to a broad international readership interested in mechanical engineering, combustion, metallurgy, materials science as well as in manufacturing and biomechanics. The reports present original ideas or results of general significance supported by clear reasoning and compelling evidence, and employ methods, theories and practices relevant to the research. The authors clearly state the questions and the significance of their research to theory and practice, describe how the research contributes to new knowledge, and provide tables and figures that meaningfully add to the narrative. In this edition of ICMER representatives attending are from academia, industry, governmental and private sectors. The plenary and invited speakers will present, discuss, promote and

  14. The radiology of joint disease. 3rd Ed

    Energy Technology Data Exchange (ETDEWEB)

    Forrester, D.M.; Brown, J.C.

    1987-01-01

    The book is a systematic radiographic approach to the arthritides. Part one deals with hand abnormalities ''to facilitate the teaching of basic principles and to dramatize the differences between radiographic features of various arthritides,'' as stated in the forward of the first edition. Part two, ''Arthritis from Head to Foot,'' illustrates the same diseases as they affect other joints. The ABCs (alignment, bone mineralization, cartilage space, soft tissue) approach is followed throughout the book. For example, reflex sympathetic dystrophy syndrome is dealt with in six different locations, and metatarsal stress fractures are mentioned in a chapter on erosions in rheumatoid arthritis.

  15. Social Movements and Their Technologies: Wiring Social Change. - Paperback edition

    NARCIS (Netherlands)

    Milan, S.

    2016-01-01

    Now in paperback for the first time, Social Movements and their Technologies explores the interplay between social movements and their 'liberated technologies'. It analyzes the rise of low-power radio stations and radical internet projects ('emancipatory communication practices') as a political

  16. Distance of mandibular foramen from 3 rd molar tooth in dry adult ...

    African Journals Online (AJOL)

    The aim of this study was to determine the distance of MF from 3rd molar tooth in both genders. Seventy dry adult mandible were included in this study. Mandible having 3rd molar tooth was selected for the study. Distance of MF from mid point of 3rd molar tooth to anterior margin of MF was measured with Vernier caliper.

  17. Frisbee - the first artificial cervical disc of 3RD generation

    Directory of Open Access Journals (Sweden)

    Karin Büttner-Janz

    2014-03-01

    Full Text Available OBJECTIVE: The current cervical disc arthroplasty is limited by postoperative facet joint arthritis, heterotopic ossification and segmental kyphosis. The total Frisbee disc, which has an upper convex/concave non-spherical surface and a lower flat sliding surface, is a new approach for improved outcomes. Prior to clinical application, safety and suitability tests are required. METHODS: The Frisbee is the first 3rd generation disc according to a new classification of total disc because it can precisely mimic the segmental ROM, including the soft limitation of axial rotation. The ISO 18192-1 test was carried out to determine the rate of wear debris. A FE model was used to assess the safety of prosthetic components. In the sagittal plane several variables to determine the most favorable lordotic angle were evaluated. RESULTS: Two angled prosthetic plates are safer than one sliding angled core to prevent the displacement. The lordosis of 7° of the Frisbee leads to kyphosis of no more than 2° without reduction of the ROM. The wear rate of the Frisbee is five times smaller compared to an FDA-approved disc with a spherical sliding surface. CONCLUSIONS: Based on the test results, the clinical application of Frisbee can now be studied. The postoperative kyphosis observed with other devices is not an issue with the Frisbee design. Physiological ROM is combined with the significant reduction of wear debris. For these reasons the Frisbee has the potential to provide a better balanced segmental loading reducing the degeneration of the joint surface and heterotopic ossification.

  18. Robotics-Control Technology. Technology Learning Activity. Teacher Edition. Technology Education Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the materials required for presenting an 8-day competency-based technology learning activity (TLA) designed to introduce students in grades 6-10 to advances and career opportunities in the field of robotics-control technology. The guide uses hands-on exploratory experiences into which activities to help students develop…

  19. [Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities].

    Science.gov (United States)

    Fan, Xiang-yu; Lin, Yan-ping; Liao, Guo-jian; Xie, Jian-ping

    2015-12-01

    Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.

  20. Technology of environmental pollution control, 2nd edition

    International Nuclear Information System (INIS)

    Shaheen, E.I.

    1991-01-01

    The final decade of the 20th century is truly the environmental decade of the century because of the gravity of environmental challenges we are facing. This book covers the environmental spectrum in an attempt to update the reader on new technologies and topics regarding pollution control. Engineers, scientists, plant operators, and students studying the subject of pollution control will use the comprehensive text as a reference for technological advances, regulations, and pollution control. The major disasters witnessed in the last few years, such as the Bhopal gas tragedy, the Chernobyl nuclear disaster, the Exxon Valdez oil spill and the Ashland of tank collapse are described in detail

  1. Application of CRISPR technology in genome editing in agriculture -swine

    Science.gov (United States)

    Decades of selective breeding in agricultural species has led to the derivation of stronger and fitter animals with improved production traits. However, often co-segregating with beneficial traits are less desirable traits. With the plethora of genome data and annotation, has come the technology t...

  2. The Third International Genomic Medicine Conference (3rd IGMC, 2015: overall activities and outcome highlights

    Directory of Open Access Journals (Sweden)

    Muhammad Abu-Elmagd

    2016-10-01

    Full Text Available Abstract The Third International Genomic Medicine Conference (3rd IGMC was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA. This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1st IGMC, 2011 followed by the second International Genomic Medicine Conference (2nd IGMC, 2013. The 3rd IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.

  3. Bookshelf (Advances of Accelerator Physics Technologies, edited by Herwig Schooper)

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Particle accelerators have always drawn upon the most advanced technologies. For Cockcroft and Walton it was high voltages, while the cyclotrons and synchrotrons that followed depended upon acceleration systems designed in the race to perfect wartime radar. As accelerators became too big for the university workshop to handle, the manufacturers of heavy electrical machinery were brought in to make hundreds of metres of electromagnets. They found the requirements of precision and reliability surpassed the quality of the best of their products and had to develop new methods of insulation and precision assembly. They now readily admit that in meeting our challenge they extended their own grasp of technology to the benefit of their less exotic customers; not to mention their shareholders. The stimulation of industry did not stop there - the physicist, by the nature of his craft, is always the first to know of what has just become possible. In their turn many industries, from those which prospect for petrochemicals to others constructing the channel tunnel, have become the technological beneficiaries of this big science. The latest of these technologies is of course that of superconductivity, and this is fully covered in this book. But in the many chapters which describe the state of the art of accelerator design, the reader will encounter numerous examples where the possible awaits an everyday application. This excellent compendium of advances in the accelerator field is therefore obligatory reading for anyone in an industry striving to deserve the label of high-tech. Not only does it for the first time draw together authoritative contributions by those who lead these technologies, but it explains how the large majority of today's accelerators are put to work to cure patients in hospital and to provide synchrotron radiation for a rich spectrum of new industrial applications. In addition there is much in the volume that is essential reading for the accelerator

  4. Strategies of Qualitative Inquiry. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  5. CMB-S4 Technology Book, First Edition

    Energy Technology Data Exchange (ETDEWEB)

    Abitbol, Maximilian H. [Columbia Univ., New York, NY (United States); et al.

    2017-06-08

    CMB-S4 is a proposed experiment to map the polarization of the Cosmic Microwave Background (CMB) to nearly the cosmic variance limit for the angular scales that are accessible from the ground. The science goals and capabilities of CMB-S4 in illuminating cosmic inflation, measuring the sum of neutrino masses, searching for relativistic relics in the early universe, characterizing dark energy and dark matter, and mapping the matter distribution in the universe have been described in the CMB-S4 Science Book. This Technology Book is a companion volume to the Science Book. The ambitious science goals of the proposed "Stage-IV" CMB-S4 will require a step forward in experimental capability from the current Stage-III experiments. To guide this process, the community summarized the current state of the technology and identify R&D efforts necessary to advance it for possible use in CMB-S4. The book focused on the technical challenges in four broad areas: Telescope Design; Receiver Optics; Focal-Plane Optical Coupling; and Focal-Plane Sensor and Readout.

  6. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    Directory of Open Access Journals (Sweden)

    Atsuo Kawahara

    2016-05-01

    Full Text Available The zebrafish (Danio rerio is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR associated protein 9 (Cas9 system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  7. Proceedings of the 3rd international symposium on material chemistry in nuclear environment (MATERIAL CHEMISTRY '02)

    International Nuclear Information System (INIS)

    2003-03-01

    The volume contains all presented papers during the 3rd International Symposium on Material Chemistry in Nuclear Environment: MATERIAL CHEMISTRY 02 (MC'02), held March 13-15, 2002. The purpose of this symposium is to provide an international forum for the discussion of recent progress in the field of materials chemistry in nuclear environments. This symposium intends to build on the success of the previous symposiums held in Tsukuba in 1992 and 1996. The topics discussed in the symposium MC'02 are Chemical Reaction and Thermodynamics, Degradation Phenomena, New Characterization Technology, Fabrication and New Materials, Composite Materials, Surface Modification, and Computational Science. The 61 of the presented papers are indexed individually. (J.P.N.)

  8. 3rd International Asia Conference on Informatics in Control, Automation and Robotics

    CERN Document Server

    Informatics in Control, Automation and Robotics

    2012-01-01

    Session 2 includes 110 papers selected from 2011 3rd International Asia Conference on Informatics in Control, Automation and Robotics (CAR 2011), held on December 24-25, 2011, Shenzhen, China.   As we all know, the ever growing technology in robotics and automation will help build a better human society. This session will provide a unique opportunity for the academic and industrial communities to address new challenges, share solutions, and discuss research directions for the future. Robotics research emphasizes intelligence and adaptability to cope with unstructured environments. Automation research emphasizes efficiency, productivity, quality, and reliability, focusing on systems that operate autonomously. The main focus of this session is on the autonomous acquisition of semantic information in intelligent robots and systems, as well as the use of semantic knowledge to guide further acquisition of information.

  9. 3rd international KES conference on Smart Education and Smart e-Learning

    CERN Document Server

    Howlett, Robert; Jain, Lakhmi

    2016-01-01

    This book contains the contributions presented at the 3rd international KES conference on Smart Education and Smart e-Learning, which took place in Puerto de la Cruz, Tenerife, Spain, June 15-17, 2016. It contains a total of 56 peer-reviewed book chapters that are grouped into several parts: Part 1 - Smart University: Conceptual Modeling, Part 2 – Smart Education: Research and Case Studies, Part 3 – Smart e-Learning, Part 4 – Smart Education: Software and Hardware Systems, and Part 5 – Smart Technology as a Resource to Improve Education and Professional Training. We believe that the book will serve as a useful source of research data and valuable information for faculty, scholars, Ph.D. students, administrators, and practitioners - those who are interested in innovative areas of smart education and smart e-learning. .

  10. 3rd International Doctoral Symposium on Applied Computation and Security Systems

    CERN Document Server

    Saeed, Khalid; Cortesi, Agostino; Chaki, Nabendu

    2017-01-01

    This book presents extended versions of papers originally presented and discussed at the 3rd International Doctoral Symposium on Applied Computation and Security Systems (ACSS 2016) held from August 12 to 14, 2016 in Kolkata, India. The symposium was jointly organized by the AGH University of Science & Technology, Cracow, Poland; Ca’ Foscari University, Venice, Italy; and the University of Calcutta, India. The book is divided into two volumes, Volumes 3 and 4, and presents dissertation works in the areas of Image Processing, Biometrics-based Authentication, Soft Computing, Data Mining, Next-Generation Networking and Network Security, Remote Healthcare, Communications, Embedded Systems, Software Engineering and Service Engineering. The first two volumes of the book published the works presented at the ACSS 2015, which was held from May 23 to 25, 2015 in Kolkata, India.

  11. Critical thinking ability of 3rd year radiography students | Pieterse ...

    African Journals Online (AJOL)

    Background: Developing the critical thinking skills of student radiographers is imperative in an era of rapidly advancing technology. The status of the students' ability to demonstrate critical thinking skills needed to be explored for the Department of Radiography at a comprehensive university to determine if a more explicit ...

  12. Greater Philadelphia Bioinformatics Alliance (GPBA) 3rd Annual Retreat 2005

    Science.gov (United States)

    2005-11-01

    least one T. gondii sequence, and at least one bacterial, archeal and/or plastid-containing organism ( plants /algae), as these represent the most...region, Dr. Handelin founded her own consulting practice, Handelin Associates, in the biopharmaceutical and technology transfer sector. She delivered

  13. 3rd International Conference on High Performance Scientific Computing

    CERN Document Server

    Kostina, Ekaterina; Phu, Hoang; Rannacher, Rolf

    2008-01-01

    This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site loca...

  14. 3rd International Conference on NeuroRehabilitation

    CERN Document Server

    González-Vargas, José; Azorín, José; Akay, Metin; Pons, José

    2017-01-01

    The book reports on advanced topics in the areas of neurorehabilitation research and practice. It focuses on new methods for interfacing the human nervous system with electronic and mechatronic systems to restore or compensate impaired neural functions. Importantly, the book merges different perspectives, such as the clinical, neurophysiological, and bioengineering ones, to promote, feed and encourage collaborations between clinicians, neuroscientists and engineers. Based on the 2016 International Conference on Neurorehabilitation (ICNR 2016) held on October 18-21, 2016, in Segovia, Spain, this book covers various aspects of neurorehabilitation research and practice, including new insights into biomechanics, brain physiology, neuroplasticity, and brain damages and diseases, as well as innovative methods and technologies for studying and/or recovering brain function, from data mining to interface technologies and neuroprosthetics. In this way, it offers a concise, yet comprehensive reference guide to neurosurg...

  15. 3rd International Conference on Sustainable Design and Manufacturing

    CERN Document Server

    Howlett, Robert; Liu, Ying; Theobald, Peter

    2016-01-01

    This volumes consists of 59 peer-reviewed papers, presented at the International Conference on Sustainable Design and Manufacturing (SDM-16) held in Chania, Crete Greece in April 2016. Leading-edge research into sustainable design and manufacturing aims to enable the manufacturing industry to grow by adopting more advanced technologies, and at the same time improve its sustainability by reducing its environmental impact. SDM-16 covers a wide range of topics from sustainable product design and service innovation, sustainable process and technology for the manufacturing of sustainable products, sustainable manufacturing systems and enterprises, decision support for sustainability, and the study of societal impact of sustainability including research for circular economy. Application areas are wide and varied. The book will provide an excellent overview of the latest research and development in the area of Sustainable Design and Manufacturing.

  16. 3rd International Conference on Health Care Systems Engineering

    CERN Document Server

    Li, Jingshan; Matta, Andrea; Sahin, Evren; Vandaele, Nico; Visintin, Filippo

    2017-01-01

    This book presents statistical processes for health care delivery and covers new ideas, methods and technologies used to improve health care organizations. It gathers the proceedings of the Third International Conference on Health Care Systems Engineering (HCSE 2017), which took place in Florence, Italy from May 29 to 31, 2017. The Conference provided a timely opportunity to address operations research and operations management issues in health care delivery systems. Scientists and practitioners discussed new ideas, methods and technologies for improving the operations of health care systems, developed in close collaborations with clinicians. The topics cover a broad spectrum of concrete problems that pose challenges for researchers and practitioners alike: hospital drug logistics, operating theatre management, home care services, modeling, simulation, process mining and data mining in patient care and health care organizations.

  17. 3rd ENRI International Workshop on ATM/CNS

    CERN Document Server

    2014-01-01

    The Electronic Navigation Research Institute (ENRI) held its third International Workshop on ATM / CNS in 2013 with the theme of "Drafting the future sky". There is worldwide activity taking place in the research and development of modern air traffic management (ATM) and its enabling technologies in Communication, Navigation and Surveillance (CNS). Pioneering work is necessary to contribute to the global harmonization of air traffic management and control. At this workshop, leading experts in  research, industry and academia from around the world met to share their ideas and approaches on ATM/CNS related topics.

  18. 3rd quarterly report 1976 of the Fast Breeder Project

    International Nuclear Information System (INIS)

    1976-12-01

    The report describes activities which were performed within the framework of the Fast Breeder Project at the Gesellschaft fuer Kernforschung mbH Karlsruhe (GfK) or on behalf of the GfK during the third quarter. It contains contributions on the following subjects: Fuel rod development, material studies and development, corrosion tests and coolant analyses, physical experiments, reactor theory, safety of fast breeders, instrumentation and signal processing for core monitoring, environmental impacts, sodium technology tests, thermo- and fluid-dynamic tests in gas, tests concerning gas-cooled breeders. (HR) [de

  19. 3rd International Conference on Applied Mathematics and Approximation Theory

    CERN Document Server

    Duman, Oktay

    2016-01-01

    This special volume is a collection of outstanding theoretical articles presented at the conference AMAT 2015, held in Ankara, Turkey from May 28-31, 2015, at TOBB University of Economics and Technology. The collection is suitable for a range of applications: from researchers and practitioners of applied and computational mathematics, to students in graduate-level seminars. Furthermore it will be a useful resource for all science libraries. This book includes 27 self-contained and expertly-refereed chapters that provide numerous insights into the latest developments at the intersection of applied and computational mathematics, engineering, and statistics.

  20. 3rd International Winter School and Conference on Network Science

    CERN Document Server

    Barzel, Baruch; Puzis, Rami

    2017-01-01

    This book contains original research chapters related to the interdisciplinary field of complex networks spanning biological and environmental networks, social, technological, and economic networks. Many natural phenomena can be modeled as networks where nodes are the primitive compounds and links represent their interactions, similarities, or distances of sorts. Complex networks have an enormous impact on research in various fields like biology, social sciences, engineering, and cyber-security to name a few. The topology of a network often encompasses important information on the functionality and dynamics of the system or the phenomenon it represents. Network science is an emerging interdisciplinary discipline that provides tools and insights to researchers in a variety of domains. NetSci-X is the central winter conference within the field and brings together leading researchers and innovators to connect, meet, and establish interdisciplinary channels for collaboration. It is the largest and best known even...

  1. Chondromyxoid fibroma of distal 1/3 rd of fibula a rare tumour at rare ...

    African Journals Online (AJOL)

    Chondromyxoid fibromas are rare, benign tumours account for <1% of primary bone neoplasms. Most commonly affected in 2nd and 3rdof life. We report one such case of chondromyxoid fibroma in distal fibula of a 15-year-old girl. The patient was managed with lower 3rd fibulectomy and fibular turnoplasty from middle 3rd ...

  2. Exercises in statistics for HA & HA(dat.) & BSc(B), 3rd semester

    DEFF Research Database (Denmark)

    The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business.......The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business....

  3. [Research Progress on Application of CRISPR/Cas Genome Editing Technology in Hematological Diseases -Review].

    Science.gov (United States)

    Xin, Liu-Yan; Liu, Ai-Fei; Zhong, Si-Si; Chen, Yi-Jian

    2016-08-01

    CRISPR/Cas genome editing technology is a newly developed powerful tool for genetic manipulation, which can be used to manipulate the genome at specific locations precisely, to restore the function of genetic defect cells, and to develop various disease models. In recentl years, with the advances of precise genome manipulation, CRISPR/Cas technology has been applied to many aspects of diseases research and becomes an unique tool to investigate gene function and discover new therapeutic targets for genetic diseases. Nowadays, CRISPR/Cas technology has been a hot research point in agriculture, graziery, biotechnology and medicine. This review focuses on the recent advances in CRISPR/Cas technology and its application in hematological diseases.

  4. Microstructure Modeling of 3rd Generation Disk Alloy

    Science.gov (United States)

    Jou, Herng-Jeng

    2008-01-01

    The objective of this initiative, funded by NASA's Aviation Safety Program, is to model, validate, and predict, with high fidelity, the microstructural evolution of third-generation high-refractory Ni-based disc superalloys during heat treating and service conditions. This initiative is a natural extension of the DARPA-AIM (Accelerated Insertion of Materials) initiative with GE/Pratt-Whitney and with other process simulation tools. Strong collaboration with the NASA Glenn Research Center (GRC) is a key component of this initiative and the focus of this program is on industrially relevant disk alloys and heat treatment processes identified by GRC. Employing QuesTek s Computational Materials Dynamics technology and PrecipiCalc precipitation simulator, physics-based models are being used to achieve high predictive accuracy and precision. Combining these models with experimental data and probabilistic analysis, "virtual alloy design" can be performed. The predicted microstructures can be optimized to promote desirable features and concurrently eliminate nondesirable phases that can limit the reliability and durability of the alloys. The well-calibrated and well-integrated software tools that are being applied under the proposed program will help gas turbine disk alloy manufacturers, processing facilities, and NASA, to efficiently and effectively improve the performance of current and future disk materials.

  5. Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

    Science.gov (United States)

    Liu, Tang; Shen, Jacson K; Li, Zhihong; Choy, Edwin; Hornicek, Francis J; Duan, Zhenfeng

    2016-04-01

    Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. 3rd International Conference on Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    1. Introduction 'Turbulent Mixing and Beyond' (TMB) is the programme established for scientists, by scientists. It is merit-based, and is shaped by requirements of academic credentials, and novelty and quality of information. The goals of this programme are to expose the generic problem of non-equilibrium turbulent processes to a wide scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in application of novel approaches in a broad range of phenomena, in which the turbulent processes occur, and to have a potential impact on technology. The programme was founded in 2007 with the support of the international scientific community and of the US National Science Foundation, the US Air Force Office of the Scientific Research and its European Office for Research and Development in the UK, the UNESCO-IAEA International Centre for Theoretical Physics in Italy, the Commissariat l'Energie Atomique in France, the US Department of Energy and the Department of Energy National Laboratories, the Institute for Laser Engineering in Japan, and the University of Chicago in the USA. The International Conference on Turbulent Mixing and Beyond provides opportunities to bring together researchers from the areas, which include but are not limited to, fluid dynamics, plasmas, high energy density physics, astrophysics, material science, combustion, atmospheric and earth sciences, nonlinear and statistical physics, applied mathematics, probability and statistics, data processing and computations, optics and communications, and to have their attention focused on the long-standing formidable task of non-equilibrium turbulent processes. 2. Non-equilibrium turbulent processes Non-equilibrium turbulent processes play a key role in a wide variety of phenomena, ranging from astrophysical to atomistic scales, under either high or low energy density conditions. Inertial confinement and magnetic fusion, light-matter interaction and

  7. Book of abstracts of the 3rd International conference and the 3rd International School for young scientists Interaction of hydrogen isotopes with structural materials. IHISM-07

    International Nuclear Information System (INIS)

    2007-01-01

    The book involves abstracts of presentations at the 3rd International Conference and the 3rd International School for Young Scientists Interaction of Hydrogen Isotopes with Structural Materials (IHISM-07). The activities of Russian and foreign scientific centers associated with the use of hydrogen isotopes in power engineering, national economy and basic research are considered. The presentations cover the following areas: kinetics and interaction between hydrogen isotopes and solids including effects of radiogenic helium accumulation, hydrides and hydride transformations; structural transformations and mechanical properties; equipment and research techniques [ru

  8. Cis-, intra-, subgenesis, genome editing as modern technologies for modifying the crop genomes (review

    Directory of Open Access Journals (Sweden)

    Н. Е. Волкова

    2016-02-01

    Full Text Available Purpose. Reviewing the literature on modern technologies of genetic modification of crop genomes. Results. The current state of genetically modified plants creation is analyzed. The information on cis-, intra- and subgenic plants and their comparison with transgenic crops is given. Examples of cis- and intragenesis application for improving characteristics of crops are provided. Such state-of-the-art technology of crop genome modification as genome editing is considered. Conclusions. Technologies for producing cis-, intra-, subgenic plants are rapidly developing and resulting in crops of the 21st century that can solve the problem of food provision for a constantly growing world population with the least contrary to the public interest.

  9. Energy Technology Roadmaps: A Guide to Development and Implementation. 2014 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-01

    New low-carbon technologies show clear potential for transforming the global energy system, but a key challenge remains: what steps do governments and industry need to take to ensure their development and deployment? Roadmapping, used for decades in technology-intensive industries, is a useful tool to help address complicated issues strategically at the national, regional and global levels. To help turn political statements and analytical work into concrete action, the International Energy Agency (IEA) is developing a series of global roadmaps devoted to low-carbon energy technologies. Drawing upon the extensive IEA experience, this guide is aimed at providing countries and companies with the context, information and tools needed to design, manage and implement an effective energy technology roadmap process relevant to their own local circumstances and objectives. This edition of the Energy Technology Roadmaps: a guide to development and implementation includes more detailed guidance on how to identify key stakeholders, develop a technology baseline and development of indicators to help track progress against roadmap milestones. The IEA hopes that this guide and the examples and references it offers, together with the new IEA How2Guides, which provide technology-specific guidance, will help national and local policy makers and industry to develop strategies that accelerate the deployment of low-carbon energy technologies worldwide.

  10. The 2001 activities and the 3rd workshop of the human resources development project in FNCA

    International Nuclear Information System (INIS)

    2002-07-01

    In 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The 3rd Workshop on Human Resources Development in the Nuclear Field was held on October 29 to November 1, at the Nuclear Training Center of KAERI. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The secretariat for the Human Resources Development Project is provided by the Nuclear Training Center of the Korea Atomic Energy Research Institute and the Nuclear Technology and Education Center of the Japan Atomic Energy Research Institute. This report consists of presentation papers and materials at the Workshop as In-Workshop Activity, a document of project review on Human Resources Development for the fourth Coordinators Meeting of FNCA at Tokyo on March, 2002, a letter of proposal from the Project Leader of Japan to the project leaders of the participating countries, and training materials of participating countries as Outside-Workshop Activity. (author)

  11. Proceedings of the 3rd workshop on ion-beam-applied biology

    International Nuclear Information System (INIS)

    Matsuhashi, Shinpei; Suzui, Nobuo; Ishioka, Noriko S.

    2005-09-01

    In order to encourage research on biological application using ion beam at TIARA, we have had the workshop on ion beam applied biology at JAERI Takasaki every year since 2002. The 3rd workshop titled 'Future development of plant research using the positron imaging method - Understanding the plant functions through visualization images-' is held this year. The main topics of this workshop are introduction of the latest studies on the assimilation and transportation of nutrients by plant using positron imaging method. Further, related technologies of the positron imaging and prospect of positron imaging for is discussed. We hope this workshop popularizes positron imaging technology for plants, accelerates cooperation between industries, universities and governmental institutes and contributes future projects of understanding of the physiological functions of plants using the positron imaging method. This workshop was held on September 29th 2004, hosted by JAERI Takasaki and cooperated by The Japan Radioisotope Association, Japanese Society of Soil Science and Plant Nutrition. The Japanese Society of Plant Physiologists, Atomic Energy Society of Japan, The Japanese Society of Nuclear and Radiochemical Science and The Ion Beam Breeding Society. There were 85 participants from not only universities and laboratories but also private company developing the environment conservation technology, so on. Highly qualified presentations were given on biological studies with ion beam, on analysis of plant functions using the positron imaging method and on supporting technology for the positron imaging monitoring. Progress in the elucidation of plant functions is expected to develop the technologies for production of safe provisions and conservation of environment with plant. The 14 of the presented papers are indexed individually. (J.P.N.)

  12. FDA Regulation of Clinical Applications of CRISPR-CAS Gene-Editing Technology.

    Science.gov (United States)

    Grant, Evita V

    Scientists have repurposed an adaptive immune system of single cell organisms to create a new type of gene-editing tool: CRISPR (clustered regularly interspaced short palindromic repeats)-Cas technology. Scientists in China have reported its use in the genome modification of non-viable human embryos. This has ignited a spirited debate about the moral, ethical, scientific, and social implications of human germline genome engineering. There have also been calls for regulations; however, FDA has yet to formally announce its oversight of clinical applications of CRISPR-Cas systems. This paper reviews FDA regulation of previously controversial biotechnology breakthroughs, recombinant DNA and human cloning. It then shows that FDA is well positioned to regulate CRISPR-Cas clinical applications, due to its legislative mandates, its existing regulatory frameworks for gene therapies and assisted reproductive technologies, and other considerations.

  13. GPM Ground Validation Airborne Precipitation Radar 3rd Generation (APR-3) OLYMPEX V2.3

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation Airborne Precipitation Radar 3rd Generation (APR-3) OLYMPEX dataset was collected from November 12, 2015 to December 19, 2015 during the...

  14. Extending CRISPR-Cas9 Technology from Genome Editing to Transcriptional Engineering in the Genus Clostridium.

    Science.gov (United States)

    Bruder, Mark R; Pyne, Michael E; Moo-Young, Murray; Chung, Duane A; Chou, C Perry

    2016-10-15

    The discovery and exploitation of the prokaryotic adaptive immunity system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins have revolutionized genetic engineering. CRISPR-Cas tools have enabled extensive genome editing as well as efficient modulation of the transcriptional program in a multitude of organisms. Progress in the development of genetic engineering tools for the genus Clostridium has lagged behind that of many other prokaryotes, presenting the CRISPR-Cas technology an opportunity to resolve a long-existing issue. Here, we applied the Streptococcus pyogenes type II CRISPR-Cas9 (SpCRISPR-Cas9) system for genome editing in Clostridium acetobutylicum DSM792. We further explored the utility of the SpCRISPR-Cas9 machinery for gene-specific transcriptional repression. For proof-of-concept demonstration, a plasmid-encoded fluorescent protein gene was used for transcriptional repression in C. acetobutylicum Subsequently, we targeted the carbon catabolite repression (CCR) system of C. acetobutylicum through transcriptional repression of the hprK gene encoding HPr kinase/phosphorylase, leading to the coutilization of glucose and xylose, which are two abundant carbon sources from lignocellulosic feedstocks. Similar approaches based on SpCRISPR-Cas9 for genome editing and transcriptional repression were also demonstrated in Clostridium pasteurianum ATCC 6013. As such, this work lays a foundation for the derivation of clostridial strains for industrial purposes. After recognizing the industrial potential of Clostridium for decades, methods for the genetic manipulation of these anaerobic bacteria are still underdeveloped. This study reports the implementation of CRISPR-Cas technology for genome editing and transcriptional regulation in Clostridium acetobutylicum, which is arguably the most common industrial clostridial strain. The developed genetic tools enable simpler, more reliable, and more extensive

  15. Recent developments at 3rd generation storage ring light sources (3/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Over the last decade, many 3rd generation storage ring light sources have been built and put into operation. Progressively, significant improvements have been brought to the machine performances and experiences developed at the first facilities have benefited to the most recently built ones. Most of the recent facilities are now featuring small emittances, high current together with high position stability. The small sizes of the electron beam at the source points impose achieving position stabilities in the sub micron range. The technology to build the insertion devices that produce the photon beams has reached a very mature state and enables 3 GeV medium energy /medium size machines to produce high brilliance beams up to the hard X-Ray range (10 - 30 keV). The designing of the optical set-up of a beamline includes now the choice of the best suited undulator. All these facilities are operated as “photon factories” and deliver their beams to many beamlines over several thousands hours per year. Some re...

  16. Recent developments at 3rd generation storage ring light sources (4/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Over the last decade, many 3rd generation storage ring light sources have been built and put into operation. Progressively, significant improvements have been brought to the machine performances and experiences developed at the first facilities have benefited to the most recently built ones. Most of the recent facilities are now featuring small emittances, high current together with high position stability. The small sizes of the electron beam at the source points impose achieving position stabilities in the sub micron range. The technology to build the insertion devices that produce the photon beams has reached a very mature state and enables 3 GeV medium energy /medium size machines to produce high brilliance beams up to the hard X-Ray range (10 - 30 keV). The designing of the optical set-up of a beamline includes now the choice of the best suited undulator. All these facilities are operated as “photon factories” and deliver their beams to many beamlines over several thousands hours per year. Some re...

  17. Recent developments at 3rd generation storage ring light sources (2/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Over the last decade, many 3rd generation storage ring light sources have been built and put into operation. Progressively, significant improvements have been brought to the machine performances and experiences developed at the first facilities have benefited to the most recently built ones. Most of the recent facilities are now featuring small emittances, high current together with high position stability. The small sizes of the electron beam at the source points impose achieving position stabilities in the sub micron range. The technology to build the insertion devices that produce the photon beams has reached a very mature state and enables 3 GeV medium energy /medium size machines to produce high brilliance beams up to the hard X-Ray range (10 - 30 keV). The designing of the optical set-up of a beamline includes now the choice of the best suited undulator. All these facilities are operated as “photon factories” and deliver their beams to many beamlines over several thousands hours per year. Some re...

  18. Recent developments at 3rd generation storage ring light sources (1/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Over the last decade, many 3rd generation storage ring light sources have been built and put into operation. Progressively, significant improvements have been brought to the machine performances and experiences developed at the first facilities have benefited to the most recently built ones. Most of the recent facilities are now featuring small emittances, high current together with high position stability. The small sizes of the electron beam at the source points impose achieving position stabilities in the sub micron range. The technology to build the insertion devices that produce the photon beams has reached a very mature state and enables 3 GeV medium energy /medium size machines to produce high brilliance beams up to the hard X-Ray range (10 - 30 keV). The designing of the optical set-up of a beamline includes now the choice of the best suited undulator. All these facilities are operated as “photon factories” and deliver their beams to many beamlines over several thousands hours per year. Some re...

  19. 3rd International Conference on Opto-Electronics and Applied Optics

    CERN Document Server

    Chakrabarti, Satyajit; Reehal, Haricharan; Lakshminarayanan, Vasudevan

    2017-01-01

    The Proceedings of 3rd International Conference on Opto-Electronics and Applied Optics, OPTRONIX 2016 is an effort to promote and present the research works by scientists and researchers including students in India and abroad in the area of Green Photonics and other related areas as well as to raise awareness about the recent trends of research and development in the area of the related fields. The book has been organized in such a way that it will be easier for the readers to go through and find out the topic of their interests. The first part includes the Keynote addresses by Rajesh Gupta, Department of Energy Science and Engineering, Indian Institute of Technology, Bombay; P.T. Ajith Kumar, President and Leading Scientist Light Logics Holography and Optics, Crescent Hill, Trivandrum, Kerala; and K.K. Ghosh, Institute of Engineering & Management, Kolkata, India.  The second part focuses on the Plenary and Invited Talks given by eminent scientists namely, Vasudevan Lakshminarayanan, University of Wate...

  20. China Satellite Navigation Conference (CSNC) 2012 Proceedings : The 3rd China Satellite Navigation Conference

    CERN Document Server

    Liu, Jingnan; Yang, Yuanxi; Fan, Shiwei

    2012-01-01

    Proceedings of the 3rd China Satellite Navigation Conference (CSNC2012) presents selected research papers from CSNC2012, held on 15-19 May in Guanzhou, China. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou system especially. They are divided into 9 topics to match the corresponding sessions in CSNC2012, which broadly covered key topics in GNSS. Readers can learn about the BeiDou system and keep abreast of the latest advances in GNSS techniques and applications. SUN Jiadong is the Chief Designer of the Compass/BeiDou system, and the Academician of Chinese Academy of Sciences; LIU Jingnan is a professor at Wuhan University, and the Academician of Chinese Academy of Engineering; YANG Yuanxi is a professor at China National Administration of GNSS and Applications, and the Academician of Chinese Academy of Sciences; FAN Shiwei öis a researcher on satellite navigation.

  1. 20 September 2013 - Ambassador Z. Akram , Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva (3rd) with Mechanical and Materials Engineering Group Leader F. Bertinelli, Head of International Relations R. Voss, CMS Collaboration, Quaid-i-Azam University H. Hoorani, Permanent Mission First Secretary U. Iqbal Jadoon and LHC Consolidation, Industrial Services, Technology Department JP. Tock in front of the lift to the LHC tunnel at Point 1. Site Manager M. Décombaz on the back.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    20 September 2013 - Ambassador Z. Akram , Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva (3rd) with Mechanical and Materials Engineering Group Leader F. Bertinelli, Head of International Relations R. Voss, CMS Collaboration, Quaid-i-Azam University H. Hoorani, Permanent Mission First Secretary U. Iqbal Jadoon and LHC Consolidation, Industrial Services, Technology Department JP. Tock in front of the lift to the LHC tunnel at Point 1. Site Manager M. Décombaz on the back.

  2. The Role of Training and Promotion to Increase The 3rd Party Funds Indonesian Islamic Banking

    Directory of Open Access Journals (Sweden)

    Rahmat Hidayat

    2014-03-01

    Full Text Available Objective – This study aims to determine whether the role of training is much larger than the promotion in raising third-party funds in Islamic banks in Indonesia given the cost of the training is spent is greater than the cost of promotion. This study empirically examines the relationship and impact of training and promotion to raise funds for a 3rd party in Indonesia Islamic banks.Methods – This study uses secondary data Islamic commercial banks in the form of panel (time-series and cross-section of Bank Indonesia data from 2010 until 2012. There are two independent variables training cost (X1 and promotion cost (X2 and one dependent variable is 3rd-party funds (Y. The analysis technique used path analysis to examine the role of training and the promotion of financial performance (The 3rd Party Funds.Result – Simultaneously, training and promotion gives an effect by 52%, and partially or individual training gives an insignificant negative effect, while the promotion has a significant positive impact on financial performance (financial-party funds on Islamic banking.Conclusion – The role of promotion is higher in raising The 3rd Party Funds than training. Keywords : Cost, Training, Promotion, The 3rd Party Funds 

  3. PREFACE: 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech 2015)

    Science.gov (United States)

    Refsnes, Magne, Prof; Gusev, Alexander, Dr; Godymchuk, Anna, Dr; Bogdan, Anna

    2015-11-01

    The 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech2015) was held on 21-22 May 2015 in Tambov, Russia, and was jointly organized by Tambov Derzhavin State University (Russia), the Norwegian Institute of Public Health (Norway), the National University of Science and Technology MISiS (Russia), Tomsk Polytechnic University (Russia) and Tomsk State University. The conference gathered experienced and young researchers, post-docs and students, working in the fieldof nanotechnologies, nanomedicine, nano(eco)toxicology and risk assessment of nanomaterials, in order to facilitate the aggregation and sharing of interests and results for better collaboration and visibility of activity. The goal of Nanobiotech2015 was to bring researchers and practitioners together to share the latest knowledge on nanotechnology-specific risks to occupational and environmental health and assessing how to reduce these potential risks. The main objective of the conference is to identify, systematize and solve current scientific problems inthe sphere of nanobiotechnologies, nanomedicine and nanotoxicology, in order to join forces todetermine prospective areas and compose working groups of interested co-workers for carrying out interdisciplinary research projects. The topics of Nanobiotech2015 were: (1) Nanotechnologies in pharmaceutics and medicine; (2) Sources and mechanisms of nanoparticle release into the environment; (3) Ecological and biological effects of nanoparticles; (4) (Eco)toxicology of nanomaterials; (5) Methods for detection of nanoparticles in the environment and in biological objects; and (6) Physico-chemical properties of nanoparticles in the environment. We want to thank the Organizing Committee, the universities and sponsors supporting the conference,and everyone who contributed to the organization of this meeting, for their contribution towards the conference and for their contributions to these

  4. 3rd May 2009 - Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, visiting ATLAS experimental area, LHC tunnel and CERN Control Centre with CERN Director-General R. Heuer, Collaboration Spokesperson F. Gianotti and Beams Department Head P. Collier.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    090506101-08: signature of the guest book and exchange of gifts; 090506109 + 46-64: Japanese Ambassador to the United Nations Office S. Kitajima, Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer, Non Member-State relations Adviser J. Ellis and ATLAS Collaboration Spokesperson F. Gianotti visiting the LHC tunnel at Point 1; 090506110-11 + 28-45: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda and his delegation visiting ATLAS experimental area with CERN Japanese users and Management; 090506112 + 86-94: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer and Japanese users in front of an LHC superconducting magnet; sLHC Project Leader also present. 090506113-19: Arrival of Japanese Min...

  5. A 3rd Order Low Power Switched Current Sigma-Delta Modulator

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Herald Holger; Bogason, Gudmundur

    1996-01-01

    This paper presents a 3rd order switched current Sigma-Delta modulator. The Sigma-Delta modulator operates at a sampling rate of 600kHz and the signal band is 5.5kHz, i.e. an oversampling factor of 54.5 is used. Multiple input signals are used to reduce the internal signal swings which results...

  6. Using Food as a Tool to Teach Science to 3rd Grade Students in Appalachian Ohio

    Science.gov (United States)

    Duffrin, Melani W.; Hovland, Jana; Carraway-Stage, Virginia; McLeod, Sara; Duffrin, Christopher; Phillips, Sharon; Rivera, David; Saum, Diana; Johanson, George; Graham, Annette; Lee, Tammy; Bosse, Michael; Berryman, Darlene

    2010-01-01

    The Food, Math, and Science Teaching Enhancement Resource (FoodMASTER) Initiative is a compilation of programs aimed at using food as a tool to teach mathematics and science. In 2007 to 2008, a foods curriculum developed by professionals in nutrition and education was implemented in 10 3rd-grade classrooms in Appalachian Ohio; teachers in these…

  7. Changes and continuity of the municipium in late Roman Gallaecia (3rd-5th centuries

    Directory of Open Access Journals (Sweden)

    Martín Fernández Calo

    2017-09-01

    Full Text Available This paper examines the evolution of local organizative framework of Gallaecia between the 3rd and 5th centuries, determining certain transformations of the municipium settled since the previous centuries and contextualizing them in the analogous evolution of the contemporary West. Finally it is stressed the apparent post-Roman permanence of the basic structure of this organizative regime.

  8. Epidemiology of 3rd generation cephalosporin-resistant Escherichia coli on dairy farms

    Science.gov (United States)

    Dairy cattle have been identified as a reservoir for 3rd generation cephalosporin (3GC)-resistant Escherichia coli. We previously identified 3GC-resistant E. coli from manure composite samples of calves and cows in a survey of 80 farms in Pennsylvania. Resistant strains were most frequently isolated...

  9. Participants to the 3rd HEP Information Resources Summit, 6-7 May 2009

    CERN Multimedia

    Fermilab, Photo Service

    2009-01-01

    The broad theme of the 3rd HEP Information Resources Summit was "Collaboration between Information Services." As HEP increasingly borders fields such as instrumentation and astrophysics, it was discussed what potential interrelationships and communication this group have to serve this broader research community seamlessly.

  10. Starting Young: Massachusetts Birth-3rd Grade Policies That Support Children's Literacy Development

    Science.gov (United States)

    Cook, Shayna; Bornfreund, Laura

    2015-01-01

    Massachusetts is one of a handful of states that is often recognized as a leader in public education, and for good reason. The Commonwealth consistently outperforms most states on national reading and math tests and often leads the pack in education innovations. "Starting Young: Massachusetts Birth-3rd Grade Policies that Support Children's…

  11. Proceedings of the 3rd fire in eastern oak forests conference

    Science.gov (United States)

    Todd F., ed. Hutchinson

    2009-01-01

    Contains 10 full-length papers and 12 abstracts of posters that were presented at the 3rd Fire in Eastern Oak Forests conference, held in Carbondale, IL, May 20-22, 2008. The conference was attended by over 200 people from a variety of groups, including federal and state agencies, nongovernmental organizations, universities, and private citizens....

  12. The 3rd International Conference on Mathematics, Science and Education 2016

    International Nuclear Information System (INIS)

    2017-01-01

    The 3 rd International Conference of Mathematics, Science, and Education (ICMSE) 2016 on Semarang, 3-4 September 2016 organized by Faculty of Mathematics and Natural Science, Semarang State University. ICMSE2016 provides a platform to the researchers, experts and practitioners from academia, governments, NGOs, research institutes, and industries to meet and share cutting-edge progress in the fields of mathematics and natural science. It is reflected in this year theme “Contribution of Mathematics and Science Research for Sustainable Life in Facing Global Challenge”. The scope of this conference are Mathematics, Biology, Chemistry, and Physics,We thank to the keynote speakers and all authors of the contributed papers, for the cooperation rendered to us in the publication of the conference proceedings. In particular, we would like to place on record our thanks to the expert reviewers who have spared their time reviewing the papers. We also highly appreciate the assistance offered by many volunteers in the preparation of the conference proceedings, and of course to the sponsors assisting in funding this conference, especially Research, Technology and Higher Education Ministry of Indonesia for supporting this conference.The committee selected 71 papers from 129 papers presented in this forum to be published in Journal of Physics: Conference Series (Institute of Physics Publisher) indexed by Scopus. We hope that this program will further stimulate research in Mathematics, Science, and Education; share research interest and information; and create a forum of collaboration and build trust relationship. We feel honored and privileged to serve the best recent developments in the field of Mathematics and Science Education to you through this exciting program.Chairperson,Dr. Margareta RahayuningsihCOMMITTEEInternational Scientific Advisory BoardEdy Cahyono ( Chemistry Department, State University of Semarang )Rahim Sahar ( Department of Physics, Universiti Teknologi

  13. SESAME — A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    Å°lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ˜133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  14. SESAME - A 3rd Generation Synchrotron Light Source for the Middle East

    International Nuclear Information System (INIS)

    Ulkue, Dincer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ∼133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  15. SESAME - A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    U˝Lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ~133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  16. Essentials of Human Anatomy and Physiology, 3rd edition Essentials of Human Anatomy and Physiology, 3rd edition Marieb E N Cummings 480pp £29.95 0-8053-4804-2 [Formula: see text].

    Science.gov (United States)

    1991-10-02

    Anatomy and physiology is a subject about which few wax lyrical. Elaine Marieb's delightful text proves to be the exception to the rule. Clearly written for those will little background knowledge in the workings of the human body, it gently explores the body in 16 systems-based, self-contained chapters.

  17. Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities, 3rd edition.

    Science.gov (United States)

    Patel, Vikram; Chisholm, Dan; Parikh, Rachana; Charlson, Fiona J; Degenhardt, Louisa; Dua, Tarun; Ferrari, Alize J; Hyman, Steve; Laxminarayan, Ramanan; Levin, Carol; Lund, Crick; Medina Mora, María Elena; Petersen, Inge; Scott, James; Shidhaye, Rahul; Vijayakumar, Lakshmi; Thornicroft, Graham; Whiteford, Harvey

    2016-04-16

    The burden of mental, neurological, and substance use (MNS) disorders increased by 41% between 1990 and 2010 and now accounts for one in every 10 lost years of health globally. This sobering statistic does not take into account the substantial excess mortality associated with these disorders or the social and economic consequences of MNS disorders on affected persons, their caregivers, and society. A wide variety of effective interventions, including drugs, psychological treatments, and social interventions, can prevent and treat MNS disorders. At the population-level platform of service delivery, best practices include legislative measures to restrict access to means of self-harm or suicide and to reduce the availability of and demand for alcohol. At the community-level platform, best practices include life-skills training in schools to build social and emotional competencies. At the health-care-level platform, we identify three delivery channels. Two of these delivery channels are especially relevant from a public health perspective: self-management (eg, web-based psychological therapy for depression and anxiety disorders) and primary care and community outreach (eg, non-specialist health worker delivering psychological and pharmacological management of selected disorders). The third delivery channel, hospital care, which includes specialist services for MNS disorders and first-level hospitals providing other types of services (such as general medicine, HIV, or paediatric care), play an important part for a smaller proportion of cases with severe, refractory, or emergency presentations and for the integration of mental health care in other health-care channels, respectively. The costs of providing a significantly scaled up package of specified cost-effective interventions for prioritised MNS disorders in low-income and lower-middle-income countries is estimated at US$3-4 per head of population per year. Since a substantial proportion of MNS disorders run a chronic and disabling course and adversely affect household welfare, intervention costs should largely be met by government through increased resource allocation and financial protection measures (rather than leaving households to pay out-of-pocket). Moreover, a policy of moving towards universal public finance can also be expected to lead to a far more equitable allocation of public health resources across income groups. Despite this evidence, less than 1% of development assistance for health and government spending on health in low-income and middle-income countries is allocated to the care of people with these disorders. Achieving the health gains associated with prioritised interventions will require not just financial resources, but committed and sustained efforts to address a range of other barriers (such as paucity of human resources, weak governance, and stigma). Ultimately, the goal is to massively increase opportunities for people with MNS disorders to access services without the prospect of discrimination or impoverishment and with the hope of attaining optimal health and social outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Republished: Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities, 3rd edition

    Directory of Open Access Journals (Sweden)

    Vikram Patel

    2016-01-01

    Full Text Available The burden of mental, neurological, and substance use (MNS disorders increased by 41% between 1990 and 2010 and now accounts for one in every 10 lost years of health globally. This sobering statistic does not take into account the substantial excess mortality associated with these disorders or the social and economic consequences of MNS disorders on affected persons, their caregivers, and society. A wide variety of effective interventions, including drugs, psychological treatments, and social interventions, can prevent and treat MNS disorders. At the population-level platform of service delivery, best practices include legislative measures to restrict access to means of self-harm or suicide and to reduce the availability of and demand for alcohol. At the community-level platform, best practices include life-skills training in schools to build social and emotional competencies. At the health-care-level platform, we identify three delivery channels. Two of these delivery channels are especially relevant from a public health perspective: self-management (eg, web-based psychological therapy for depression and anxiety disorders and primary care and community outreach (eg, non-specialist health worker delivering psychological and pharmacological management of selected disorders. The third delivery channel, hospital care, which includes specialist services for MNS disorders and first-level hospitals providing other types of services (such as general medicine, HIV, or paediatric care, play an important part for a smaller proportion of cases with severe, refractory, or emergency presentations and for the integration of mental health care in other health-care channels, respectively. The costs of providing a significantly scaled up package of specified cost-effective interventions for prioritised MNS disorders in low-income and lower-middle-income countries is estimated at US$3-4 per head of population per year. Since a substantial proportion of MNS disorders run a chronic and disabling course and adversely affect household welfare, intervention costs should largely be met by government through increased resource allocation and financial protection measures (rather than leaving households to pay out-of-pocket. Moreover, a policy of moving towards universal public finance can also be expected to lead to a far more equitable allocation of public health resources across income groups. Despite this evidence, less than 1% of development assistance for health and government spending on health in low-income and middle-income countries is allocated to the care of people with these disorders. Achieving the health gains associated with prioritised interventions will require not just financial resources, but committed and sustained efforts to address a range of other barriers (such as paucity of human resources, weak governance, and stigma. Ultimately, the goal is to massively increase opportunities for people with MNS disorders to access services without the prospect of discrimination or impoverishment and with the hope of attaining optimal health and social outcomes.

  19. Improvements for international medicine donations: a review of the World Health Organization Guidelines for Medicine Donations, 3rd edition.

    Science.gov (United States)

    Cañigueral-Vila, Nuria; Chen, Jennifer C; Frenkel-Rorden, Lindsey; Laing, Richard

    2015-01-01

    Some humanitarian and development organizations respond to major natural disasters and emergencies by donating medicines. Many provide medicines on a routine basis to support health systems, particularly those run by Faith-Based Organizations. Although such donations can provide essential medicines to populations in great need, inappropriate donations also take place, with burdensome consequences. The World Health Organization (WHO) has developed the interagency Guidelines for Medicine Donations for use by donors and recipients in the context of emergency aid and international development assistance. Although comprehensive in nature and transferable to various emergency situations, adjustments to both content and formatting would improve this resource. Recommendations for the next version of these guidelines include: specific wording and consistent formatting; definition of who is a recipient, clear distinction between acute and long-term emergencies, and proper donation procedures pertaining to each; inclusion of visual aides such as flowcharts, checklists, and photos; and improving the citations system.

  20. Red list of Czech spiders: 3rd edition, adjusted according to evidence-based national conservation priorities

    Czech Academy of Sciences Publication Activity Database

    Řezáč, M.; Kůrka, A.; Růžička, Vlastimil; Heneberg, P.

    2015-01-01

    Roč. 70, č. 5 (2015), s. 645-666 ISSN 0006-3088 Grant - others:MZe(CZ) RO0415 Institutional support: RVO:60077344 Keywords : evidence-based conservation * extinction risk * invertebrate surveys Subject RIV: EG - Zoology Impact factor: 0.719, year: 2015

  1. Assessment of acute head injury in an emergency department population using sport concussion assessment tool - 3rd edition.

    Science.gov (United States)

    Bin Zahid, Abdullah; Hubbard, Molly E; Dammavalam, Vikalpa M; Balser, David Y; Pierre, Gritz; Kim, Amie; Kolecki, Radek; Mehmood, Talha; Wall, Stephen P; Frangos, Spiros G; Huang, Paul P; Tupper, David E; Barr, William; Samadani, Uzma

    2018-01-01

    Sport Concussion Assessment Tool version 3 (SCAT-3) is one of the most widely researched concussion assessment tools in athletes. Here normative data for SCAT3 in nonathletes are presented. The SCAT3 was administered to 98 nonathlete healthy controls, as well as 118 participants with head-injury and 46 participants with other body trauma (OI) presenting to the ED. Reference values were derived and classifier functions were built to assess the accuracy of SCAT3. The control population had a mean of 2.30 (SD = 3.62) symptoms, 4.38 (SD = 8.73) symptom severity score (SSS), and 26.02 (SD = 2.52) standardized assessment of concussion score (SAC). Participants were more likely to be diagnosed with a concussion (from among healthy controls) if the SSS > 7; or SSS ≤ 7 and SAC ≤22 (sensitivity = 96%, specificity = 77%). Identification of head injury patients from among both, healthy controls and body trauma was possible using rule SSS > 7 and headache or pressure in head present, or SSS ≤ 7 and SAC ≤ 22 (sensitivity = 87%, specificity = 80%). In this current study, the SCAT-3 provided high sensitivity to discriminate acute symptoms of TBI in the ED setting. Individuals with a SSS > 7 and headache or pressure in head, or SSS ≤ 7 but with a SAC ≤ 22 within 48-hours of an injury should undergo further testing.

  2. Correlates and Phenomenology of 1st and 3rd Person Memories

    Science.gov (United States)

    Sutin, Angelina R.; Robins, Richard W.

    2010-01-01

    The present research addressed fundamental questions about the visual perspective of autobiographical memories: Are stable personality characteristics associated with visual perspective? Does visual perspective influence the memory's phenomenological qualities? Participants in Study 1 (N = 1,684) completed individual-difference measures and indicated the perspective from which they generally retrieve memories. Participants in Study 2 (N = 706) retrieved a memory from their natural or manipulated perspective, rated its phenomenology, and completed the same individual-difference measures. Dissociation and anxiety were associated with 3rd person retrieval style; the Big Five personality traits were primarily unrelated to perspective. Compared to 3rd person memories, naturally-occurring 1st person memories were higher on Vividness, Coherence, Accessibility, Sensory Detail, Emotional Intensity, and Time Perspective and lower on Distancing; manipulating perspective eliminated these differences. Visual perspective is associated with clinically-relevant constructs and, although associated with the memory's phenomenology, perspective does not shape it. PMID:20665336

  3. The Settling of Mordovians in 3rd — Early 13th Centuries

    Directory of Open Access Journals (Sweden)

    Vikhlyaev Viktor I.

    2013-06-01

    Full Text Available Changes in the territorial extension of the Mordovians over the millennial period (the 3rd to the 13th centuries are discussed, and causes of the displacement are determined in the article. The three major periods are identified in the process: the 3rd to the 7th, the 8th to the 11th, and the 11th to the 13th centuries. The 3rd century marked the appearance of ancient burial grounds containing decorations that are ethnically typical of the Mordovians. The heyday of the ancient Mordovian culture in the late 3rd and first half of the 5th centuries was accompanied by the expansion of its territory to the north. By the late 7th – first half of the 8th century, two options of the ancient Mordovian culture were formed: the Erzya in the north and the Moksha in the south. In the 8th–11th centuries, the Moksha Mordvins settlement territory shifted to the north-west, which could be associated with the danger from the Khazar Khanate. The territory of the Erzya Mordvins settlement did not change in the period. In the 11th-13th centuries, and the Mordovian population fell into the spheres of influence of Kievan Rus and Volga Bulgaria. The struggle between these states, and later the princely strife in Russia, led to the resettlement of the Mordovians to safer areas: the Moksha moved to the Moksha-Vad river interfluve, while the Erzya relocated to the Tyosha river basin

  4. Sandstone columns of the 3rd Nile Cataract (Nubia, Northern Sudan)

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav; Adamovič, Jiří; Suková, L.

    2015-01-01

    Roč. 59, Supplement 1 (2015), s. 151-165 ISSN 0372-8854 Grant - others:Program interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M100130902 Institutional support: RVO:67985831 Keywords : Nubian sandstone * column ar jointing * Voronoi fragmentation * 3rd Nile Cataract * Sudan Subject RIV: DB - Geology ; Mineralogy Impact factor: 1.103, year: 2015

  5. Preliminary Location Accuracy Assessments of 3rd Satellite of TH-1

    Directory of Open Access Journals (Sweden)

    WANG Renxiang

    2016-10-01

    Full Text Available The TH-1 satellite is the first stereo mapping transmission satellite in China, and the primary mission goal of the satellite is for topographic mapping at 1:50 000 scale and high-accuracy location without Ground Control Points (GCPs. 1st, 2nd satellites of TH-1 were launched on August 24, 2010, May 6, 2012, and 3rd satellite was launched on October 26, 2015. Now, three satellites of TH-1 are well operating on its orbit. After evaluation, the location accuracy of 1st satellite without GCPs is 10.3 m/5.7 m (horizontal accuracy/vertical elevation accuracy, and the location accuracy of 2nd is equivalent with 1st satellite. In this paper, the system overview of TH-1 and the key technical in ground image processing are introduced. Then, the preliminary location accuracy of 3rd is assessed. The results are shown using three routes images:the location accuracy of 3rd is higher than 2nd, and can realize high accuracy location without GCPs, in which the horizontal accuracy is 7.2 m, and the vertical elevation accuracy is 2.6 m.

  6. Recent advances on developing 3rd generation enzyme electrode for biosensor applications.

    Science.gov (United States)

    Das, Priyanki; Das, Madhuri; Chinnadayyala, Somasekhar R; Singha, Irom Manoj; Goswami, Pranab

    2016-05-15

    The electrochemical biosensor with enzyme as biorecognition element is traditionally pursued as an attractive research topic owing to their high commercial perspective in healthcare and environmental sectors. The research interest on the subject is sharply increased since the beginning of 21st century primarily, due to the concomitant increase in knowledge in the field of material science. The remarkable effects of many advance materials such as, conductive polymers and nanomaterials, were acknowledged in the developing efficient 3rd generation enzyme bioelectrodes which offer superior selectivity, sensitivity, reagent less detection, and label free fabrication of biosensors. The present review article compiles the major knowledge surfaced on the subject since its inception incorporating the key review and experimental papers published during the last decade which extensively cover the development on the redox enzyme based 3rd generation electrochemical biosensors. The tenet involved in the function of these direct electrochemistry based enzyme electrodes, their characterizations and various strategies reported so far for their development such as, nanofabrication, polymer based and reconstitution approaches are elucidated. In addition, the possible challenges and the future prospects in the development of efficient biosensors following this direct electrochemistry based principle are discussed. A comparative account on the design strategies and critical performance factors involved in the 3rd generation biosensors among some selected prominent works published on the subject during last decade have also been included in a tabular form for ready reference to the readers. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. The effect of introducing increased-reliability-risk electronic components into 3rd generation telecommunications systems

    International Nuclear Information System (INIS)

    Salmela, Olli

    2005-01-01

    In this paper, the dependability of 3rd generation telecommunications network systems is studied. Special attention is paid to a case where increased-reliability-risk electronic components are introduced to the system. The paper consists of three parts: First, the reliability data of four electronic components is considered. This includes statistical analysis of the reliability test data, thermo-mechanical finite element analysis of the printed wiring board structures, and based on those, a field reliability estimate of the components is constructed. Second, the component level reliability data is introduced into the network element reliability analysis. This is accomplished by using a reliability block diagram technique and Monte Carlo simulation of the network element. The end result of the second part is a reliability estimate of the network element with and without the high-risk component. Third, the whole 3rd generation network having multiple network elements is analyzed. In this part, the criticality of introducing high-risk electronic components into a 3rd generation telecommunications network is considered

  8. The effect of introducing increased-reliability-risk electronic components into 3rd generation telecommunications systems

    Energy Technology Data Exchange (ETDEWEB)

    Salmela, Olli [Nokia Networks, P.O. Box 301, 00045 Nokia Group (Finland)]. E-mail: olli.salmela@nokia.com

    2005-08-01

    In this paper, the dependability of 3rd generation telecommunications network systems is studied. Special attention is paid to a case where increased-reliability-risk electronic components are introduced to the system. The paper consists of three parts: First, the reliability data of four electronic components is considered. This includes statistical analysis of the reliability test data, thermo-mechanical finite element analysis of the printed wiring board structures, and based on those, a field reliability estimate of the components is constructed. Second, the component level reliability data is introduced into the network element reliability analysis. This is accomplished by using a reliability block diagram technique and Monte Carlo simulation of the network element. The end result of the second part is a reliability estimate of the network element with and without the high-risk component. Third, the whole 3rd generation network having multiple network elements is analyzed. In this part, the criticality of introducing high-risk electronic components into a 3rd generation telecommunications network is considered.

  9. Intelligence and Technology. Joint Force Quarterly, Issue 46, 3rd Quarter 2007

    Science.gov (United States)

    2007-01-01

    community planners, analysts, and decisionmakers U .S . N av y (S te ph en W ea ve r) USS Gonzalez  participates in  exercise as part of...e R m a l k a s i a n Troops wait to attack insurgents as part of  Operation Al Fajr in Fallujah U .S . M ar in e C or ps (J oe l C ha ve rr i) The...an Albu Mahal tribal leader expressed the need for a major clear- ing operation: “It would be insane to attack Zarqawi’s people, even to shoot one

  10. 3rd International Conference on Numerical Analysis and Optimization : Theory, Methods, Applications and Technology Transfer

    CERN Document Server

    Grandinetti, Lucio; Purnama, Anton

    2015-01-01

    Presenting the latest findings in the field of numerical analysis and optimization, this volume balances pure research with practical applications of the subject. Accompanied by detailed tables, figures, and examinations of useful software tools, this volume will equip the reader to perform detailed and layered analysis of complex datasets. Many real-world complex problems can be formulated as optimization tasks. Such problems can be characterized as large scale, unconstrained, constrained, non-convex, non-differentiable, and discontinuous, and therefore require adequate computational methods, algorithms, and software tools. These same tools are often employed by researchers working in current IT hot topics such as big data, optimization and other complex numerical algorithms on the cloud, devising special techniques for supercomputing systems. The list of topics covered include, but are not limited to: numerical analysis, numerical optimization, numerical linear algebra, numerical differential equations, opt...

  11. Radioactive waste management. Introductory statement of the 3rd scientific forum during the 44th session of the IAEA General Conference. Vienna, 19 September 2000

    International Nuclear Information System (INIS)

    ElBaradei, M.

    2000-01-01

    The document reproduces the text of the introductory statement made by the Director General of the IAEA at the 3rd scientific forum organized during the 44th session of the IAEA General Conference, Vienna, 19 september 2000, on the management of radioactive waste. He emphasized the following aspects: progress made in technology and public acceptance, global challenges, international co-operation, building a stronger framework

  12. 3rd International School of Trigger and Data Acquisition - Cracow (Poland), 1 – 8 February 2012

    CERN Multimedia

    Yi Ling

    2011-01-01

    After two successful editions of the International School of Trigger and Data Acquisition (ISOTDAQ), the ISOTDAQ 2012 is the third of a series of this International School dedicated to introduce MSc and PhD students to the arts and crafts of triggering and acquiring data for physics experiments. The school will be held from 1 – 8 February 2012 in the Cracow University of Technology and Institute of Nuclear Physics, Cracow, Poland.  The school provides an up-to-date overview of the basic instruments and methodologies used in high energy physics, spanning from small experiences in lab to the very large LHC experiments, spotting the main building blocks as well as the different solutions and architectures at different levels of complexity. The main topics of the school include the basics of Data Acquisition (DAQ) programming concepts (e.g. threaded programming, data storage, networking, IO programming), hardware bus systems (VME bus, PCI), Trigger logic and Hardware (NIM). PC based readout...

  13. Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.

    Science.gov (United States)

    Smith, Andrew J P; Deloukas, Panos; Munroe, Patricia B

    2018-04-13

    Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning towards the function of these association signals, determining the causal variant(s) amongst those in strong linkage disequilibrium, and identifying their underlying mechanisms, such as long-range gene regulation. Genome-editing techniques utilising zinc-finger nucleases (ZFN), transcription activator-like effector nucleases (TALENs) and clustered regularly-interspaced short palindromic repeats with Cas9 nuclease (CRISPR-Cas9), are becoming the tools of choice to establish functionality for these variants, due to the ability to assess effects of single variants in vivo. This review will discuss examples of how these technologies have begun to aid functional analysis of GWAS loci for complex traits such as cardiovascular disease, type 2 diabetes, cancer, obesity and autoimmune disease. We focus on analysis of variants occurring within non-coding genomic regions, as these comprise the majority of GWAS variants, providing the greatest challenges to determining functionality, and compare editing strategies that provide different levels of evidence for variant functionality. The review describes molecular insights into some of these potentially causal variants, and how these may relate to the pathology of the trait, and look towards future directions for these technologies in post-GWAS analysis, such as base-editing.

  14. FOREWORD: 3rd International Workshop on New Computational Methods for Inverse Problems (NCMIP 2013)

    Science.gov (United States)

    Blanc-Féraud, Laure; Joubert, Pierre-Yves

    2013-10-01

    Conference logo This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 3rd International Workshop on New Computational Methods for Inverse Problems, NCMIP 2013 (http://www.farman.ens-cachan.fr/NCMIP_2013.html). This workshop took place at Ecole Normale Supérieure de Cachan, in Cachan, France, on 22 May 2013, at the initiative of Institut Farman. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of the ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 (http://www.farman.ens-cachan.fr/NCMIP_2012.html). The NCMIP Workshop focused on recent advances in the resolution of inverse problems. Indeed inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational

  15. The role of hemorrhoidopexy in the management of 3rd degree hemorrhoids.

    Science.gov (United States)

    Pramateftakis, M G

    2010-11-01

    Hemorrhoidopathy is a very common benign surgical pathology. Hemorrhoids are divided into 4 stages, depending on symptoms and degree of prolapse. Hemorrhoidopexy is a technique developed for the treatment of 3rd degree hemorrhoids, but its application has been extended to the treatment of 4th degree hemorrhoids as well. Nevertheless, recent studies identify weaknesses of the PPH in the treatment of 4th degree hemorrhoids. One hundred and twenty-six consecutive patients with 3rd degree hemorrhoids underwent stapled hemorrhoidopexy. All procedures were performed under general anesthesia with the patient in lithotomy position. A phosphate enema was given to the patient 2 h before the procedure, and cephalosporine and metronidazole were administered at anesthesia induction. Most patients were discharged the day after the operation. All patients were reassessed at 1, 6 weeks, 6 and 12 months after the procedure. The mean operating time was 16.3 min. Of all patients, 5.8% complained of mild rectal pain for a post-operative period of 5-12 days, 5.8% developed post-operative urinary retention, managed with catheterization, 13.3% experienced fecal urgency while 5.8% experienced gas incontinence, which subsided 2-8 weeks from surgery. The mean hospital stay was 1.2 days. Most patients returned to daily activities within 2-5 days. Ninety-five percent of patients returned for their follow-up visits. Recurrence of the disease occurred in 8 patients (6.6%). It was managed conservatively in 2 patients, 3 underwent redo hemorrhoidopexy and 3 underwent classic hemorrhoidectomy. According to our results, stapled hemorrhoidopexy seems to be a safe, pain-free and, in the long-term, effective technique for the treatment of 3rd degree hemorrhoids.

  16. Use of CRISPR/Cas Genome Editing Technology for Targeted Mutagenesis in Rice.

    Science.gov (United States)

    Xu, Rongfang; Wei, Pengcheng; Yang, Jianbo

    2017-01-01

    Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) system is a newly emerging mutagenesis (gene-editing) tool in genetic engineering. Among the agriculturally important crops, several genes have been successfully mutated by the system, and some agronomic important traits have been rapidly generated, which indicates the potential applications in both scientific research and plant breeding. In this chapter, we describe a standard gene-editing procedure to effectively target rice genes and to make specific rice mutants using the CRISPR/Cas9 system mediated by Agrobacterium transformation.

  17. Umbilical hypercoiling in 2nd- and 3rd-trimester intrauterine fetal death.

    Science.gov (United States)

    Dutman, Annemiek C; Nikkels, Peter G J

    2015-01-01

    Cases of unexplained intrauterine fetal death (IUFD) can be reduced by full placental examination, with or without autopsy. Determination of the umbilical coiling index (UCI) is considered to be a part of full placental examination. Umbilical hypercoiling (UCI above 0.30 coils/cm) is associated with IUFD. In a large retrospective study, we found an incidence of 18% umbilical hypercoiling in IUFD. We explored the association between umbilical hypercoiling and 2nd- and 3rd-trimester IUFD in 77 cases. There was a significant negative correlation between the UCI and gestational age of IUFD (PUCI should be part of the routine placental examination of cases of IUFD.

  18. 3rd International Conference on Computer Science, Applied Mathematics and Applications

    CERN Document Server

    Nguyen, Ngoc; Do, Tien

    2015-01-01

    This volume contains the extended versions of papers presented at the 3rd International Conference on Computer Science, Applied Mathematics and Applications (ICCSAMA 2015) held on 11-13 May, 2015 in Metz, France. The book contains 5 parts: 1. Mathematical programming and optimization: theory, methods and software, Operational research and decision making, Machine learning, data security, and bioinformatics, Knowledge information system, Software engineering. All chapters in the book discuss theoretical and algorithmic as well as practical issues connected with computation methods & optimization methods for knowledge engineering and machine learning techniques.  

  19. 3rd International Symposium on Big Data and Cloud Computing Challenges

    CERN Document Server

    Neelanarayanan, V

    2016-01-01

    This proceedings volume contains selected papers that were presented in the 3rd International Symposium on Big data and Cloud Computing Challenges, 2016 held at VIT University, India on March 10 and 11. New research issues, challenges and opportunities shaping the future agenda in the field of Big Data and Cloud Computing are identified and presented throughout the book, which is intended for researchers, scholars, students, software developers and practitioners working at the forefront in their field. This book acts as a platform for exchanging ideas, setting questions for discussion, and sharing the experience in Big Data and Cloud Computing domain.

  20. 3rd IFToMM Symposium on Mechanism Design for Robotics

    CERN Document Server

    Ceccarelli, Marco

    2015-01-01

    This volume contains the Proceedings of the 3rd IFToMM Symposium on Mechanism Design for Robotics, held in Aalborg, Denmark, 2-4 June, 2015. The book contains papers on recent advances in the design of mechanisms and their robotic applications. It treats the following topics: mechanism design, mechanics of robots, parallel manipulators, actuators and their control, linkage and industrial manipulators, innovative mechanisms/robots and their applications, among others. The book can be used by researchers and engineers in the relevant areas of mechanisms, machines and robotics.

  1. Announced document collection of the 3rd information exchange meeting on radioactive waste disposal research network

    International Nuclear Information System (INIS)

    2008-03-01

    The 3rd meeting on 'Radioactive Waste Disposal Research Network' was held at the Ricotti techno community square of JAEA on September 3 and 4, 2007. The 'Radioactive Waste Disposal Research Network' was established in Interorganization Atomic Energy Research Program under academic collaborative agreement between Japan Atomic Energy Agency and the University of Tokyo. The objective is to bring both research infrastructures and human expertise in Japan to an adequate performance level, thereby contributing to the development of the fundamental research area in the field of radioactive waste disposal. This lecture material is a collection of presentations and discussions during the information exchange meeting. (author)

  2. 3rd International Conference on Modelling, Computation and Optimization in Information Systems and Management Sciences

    CERN Document Server

    Dinh, Tao; Nguyen, Ngoc

    2015-01-01

    This proceedings set contains 85 selected full papers presented at the 3rd International Conference on Modelling, Computation and Optimization in Information Systems and Management Sciences - MCO 2015, held on May 11–13, 2015 at Lorraine University, France. The present part I of the 2 volume set includes articles devoted to Combinatorial optimization and applications, DC programming and DCA: thirty years of Developments, Dynamic Optimization, Modelling and Optimization in financial engineering, Multiobjective programming, Numerical Optimization, Spline Approximation and Optimization, as well as Variational Principles and Applications

  3. [Application progress of CRISPR/Cas9 genome editing technology in the treatment of HIV-1 infection].

    Science.gov (United States)

    Han, Ying-lun; Li, Qing-wei

    2016-01-01

    The goal of gene therapy is to introduce foreign genes into human target cells in a certain way to correct or compensate diseases caused by defective or abnormal genes. Therefore, gene therapy has great practical significance in studying the treatment of persistent or latent HIV-1 infection. At present, the existing methods of gene therapy have some major defects such as limited target site recognition and high frequency of off-targets. The latest research showed that the clustered regularly interspaced short palindromic repeats (CRISPR) /CRISPR-associated nuclease 9 (Cas9) system from bacteria and archaea has been successfully reformed to a targeted genome editing tool. Thus, how to achieve the goal of treating HIV-1 infection by modifying targeted HIV-1 virus genome effectively using the CRISPR/Cas9 system has become a current research focus. Here we review the latest achievements worldwide and briefly introduce applications of the CRISPR/Cas9 genome editing technology in the treatment of HIV-1 infection, including CCR5 gene editing, removal of HIV-1 virus and activation of HIV-1 virus, in order to provide reference for the prevention and treatment of HIV-1 infection.

  4. Teaching Newton's 3rd law of motion using learning by design approach

    Science.gov (United States)

    Aquino, Jiezel G.; Caliguid, Mariel P.; Buan, Amelia T.; Magsayod, Joy R.; Lahoylahoy, Myrna E.

    2018-01-01

    This paper presents the process and implementation of Learning by Design Approach in teaching Newton's 3rd Law of Motion. A lesson activity from integrative STEM education was adapted, modified and enhanced through pilot testing. After revisions, the implementation was done to one class. The respondent's prior knowledge was first assessed by a pretest. PPIT (present the scenario, plan, implement and test) was the framework followed in the implementation of Learning by Design. Worksheets were then utilized to measure their conceptual understanding and perception. A score guide was also used to evaluate the student's output. Paired t-test analysis showed that there is a significant difference in the pretest and posttest achievement scores. This implies that the performance of the students have improved during the implementation of the Learning by Design. The Analysis of variance also depicts that the low, average and high benefited in the Learning by Design approach. The results of this study suggests that Learning by Design is an effective approach in teaching Newton's 3rd Law of Motion and thus be used in a Science classroom.

  5. Formal faculty observation and assessment of bedside skills for 3rd-year neurology clerks.

    Science.gov (United States)

    Thompson Stone, Robert; Mooney, Christopher; Wexler, Erika; Mink, Jonathan; Post, Jennifer; Jozefowicz, Ralph F

    2016-11-22

    To evaluate the feasibility and utility of instituting a formalized bedside skills evaluation (BSE) for 3rd-year medical students on the neurology clerkship. A neurologic BSE was developed for 3rd - year neurology clerks at the University of Rochester for the 2012-2014 academic years. Faculty directly observed 189 students completing a full history and neurologic examination on real inpatients. Mock grades were calculated utilizing the BSE in the final grade, and number of students with a grade difference was determined when compared to true grade. Correlation was explored between the BSE and clinical scores, National Board of Medical Examiners (NBME) scores, case complexity, and true final grades. A survey was administered to students to assess their clinical skills exposure and the usefulness of the BSE. Faculty completed and submitted a BSE form for 88.3% of students. There was a mock final grade change for 13.2% of students. Correlation coefficients between BSE score and clinical score/NBME score were 0.36 and 0.35, respectively. A statistically significant effect of BSE was found on final clerkship grade (F 2,186 = 31.9, p neurology clerkship was feasible. Low correlation between BSE score and other evaluations indicated a unique measurement to contribute to student grade. Using real patients with differing case complexity did not alter the grade. © 2016 American Academy of Neurology.

  6. 'A good midwife stands out': 3rd year midwifery students' views.

    Science.gov (United States)

    Carolan, Mary

    2013-02-01

    the midwifery workforce in Australia is ageing and predominantly part-time. There is considerable interest in the induction and retention of new midwives in the profession. this study was undertaken to explore 3rd year students' views of the good midwife. It was anticipated that student views would show evidence of early transition and socialisation into the profession. qualitative thematic analysis. Melbourne, Australia all completing midwifery students, in 2010, were invited to participate (n=31). three broad themes emerged from the analysis: (1) a skilled practitioner; (2) a caring and compassionate individual; and (3) beyond the call of duty: passion and enthusiasm for midwifery. it was evident that 3rd year students' views of the good midwife were becoming aligned with the views of qualified midwives. Students also acknowledged the importance of safe practice at the same time as supporting women to make decisions. However, their intense passion and enthusiasm for midwifery practice may make them vulnerable to disappointment with the profession. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Peter Gee

    2017-01-01

    Full Text Available In the past decade, the development of two innovative technologies, namely, induced pluripotent stem cells (iPSCs and the CRISPR Cas9 system, has enabled researchers to model diseases derived from patient cells and precisely edit DNA sequences of interest, respectively. In particular, Duchenne muscular dystrophy (DMD has been an exemplary monogenic disease model for combining these technologies to demonstrate that genome editing can correct genetic mutations in DMD patient-derived iPSCs. DMD is an X-linked genetic disorder caused by mutations that disrupt the open reading frame of the dystrophin gene, which plays a critical role in stabilizing muscle cells during contraction and relaxation. The CRISPR Cas9 system has been shown to be capable of targeting the dystrophin gene and rescuing its expression in in vitro patient-derived iPSCs and in vivo DMD mouse models. In this review, we highlight recent advances made using the CRISPR Cas9 system to correct genetic mutations and discuss how emerging CRISPR technologies and iPSCs in a combined platform can play a role in bringing a therapy for DMD closer to the clinic.

  8. Improving livestock for agriculture - technological progress from random transgenesis to precision genome editing heralds a new era.

    Science.gov (United States)

    Laible, Götz; Wei, Jingwei; Wagner, Stefan

    2015-01-01

    Humans have a long history in shaping the genetic makeup of livestock to optimize production and meet growing human demands for food and other animal products. Until recently, this has only been possible through traditional breeding and selection, which is a painstakingly slow process of accumulating incremental gains over a long period. The development of transgenic livestock technology offers a more direct approach with the possibility for making genetic improvements with greater impact and within a single generation. However, initially the technology was hampered by technical difficulties and limitations, which have now largely been overcome by progressive improvements over the past 30 years. Particularly, the advent of genome editing in combination with homologous recombination has added a new level of efficiency and precision that holds much promise for the genetic improvement of livestock using the increasing knowledge of the phenotypic impact of genetic sequence variants. So far not a single line of transgenic livestock has gained approval for commercialization. The step change to genome-edited livestock with precise sequence changes may accelerate the path to market, provided applications of this new technology for agriculture can deliver, in addition to economic incentives for producers, also compelling benefits for animals, consumers, and the environment. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Proceedings of the 3rd seminar of R and D on advanced ORIENT (International)

    International Nuclear Information System (INIS)

    Sasaki, Yuji; Ozawa, Masaki

    2010-03-01

    The 3rd Seminar of R and D on advanced ORIENT (International) was held at Tohoku University, on October 30th, 2009 organized by Japan Atomic Energy Agency. The first meeting of this seminar was held at Oarai, Ibaraki on May, 2007, and the second seminar was held at Tokai, Ibaraki on November, 2008. This seminar has the world-wide concept and includes the main topics from foreign researchers. Spent nuclear fuel should be recognized not only mass of radioactive elements but also potentially useful materials including platinum metals and rare earth elements. Taking the cooperation with universities related companies and research institutes, into consideration, we aimed at expanding and progressing the basic researches. This report records abstracts and figures submitted from the oral speakers in this seminar. (author)

  10. 3rd International Summer School Nanotechnology : From Fundamental Research to Innovations

    CERN Document Server

    Yatsenko, Leonid

    2015-01-01

    This book highlights the most recent advances in nanoscience from leading researchers in Ukraine, Europe, and beyond.  It features contributions from participants of the 3rd International Summer School “Nanotechnology: From Fundamental Research to Innovations,” held in Yaremche, Ukraine on August 23-26, 2014 and of the 2nd International NANO-2014 Conference, held in Lviv, Ukraine on August 27-30, 2014.  These events took place within the framework of the European Commission FP7 project Nanotwinning, and were organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), University of Turin (Italy), and Pierre and Marie Curie University (France).  Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results in the areas of nanocomposites and nanomaterials, nanostructured surfaces, microscopy of nano-objects, nano-optics and nanophotonics, nanoplasmonics, nanochemistry, na...

  11. Relation between physical activity and academic performance in 3rd-year secondary education students.

    Science.gov (United States)

    Morales, José; Pellicer-Chenoll, Maite; García-Masso, Xavier; Gomis, Manuel; González, Luis-Millán

    2011-10-01

    The main aim of this study was to analyze the relationship between the amount of physical activity and academic performance in 3rd-year secondary education students. The sample was taken from three secondary schools in the area of Barcelona. 284 students (158 girls, 126 boys) with an average age of 14.7 yr. participated. The International Physical Activity Questionnaire was used by students to self-report their amount of physical activity. Students' academic records were obtained for comparisons. Results showed that there was a linear relationship between academic performance and physical activity; nevertheless, there was a trend to stronger correlation when modeling the relationship between these variables with a quadratic equation. Further research should focus on whether academic performance and physical activity might be better explained with a second-order equation.

  12. Passive solar progress: a simplified guide to the 3rd national passive solar conference

    Energy Technology Data Exchange (ETDEWEB)

    Miller, H.; Howell, Y.; Richards, D.

    1980-10-01

    Some of the concepts and practices that have come to be known as passive solar heating and cooling are introduced, and a current picture of the field is presented. Much of the material presented is derived from papers given at the 3rd National Passive Solar Conference held in San Jose, California in January 1979 and sponsored by the US Department of Energy. Extracts and data from these papers have been integrated in the text with explanatory and descriptive material. In this way, it is attempted to present technical information in an introductory context. Topics include design considerations, passive and hybrid systems and applications, sizing methods and performance prediction, and implementation issues. A glossary is included. (WHK)

  13. 3rd International Conference on Modelling and Management of Engineering Processes

    CERN Document Server

    Gericke, Kilian; Szélig, Nikoletta; Vajna, Sándor

    2015-01-01

    Innovative processes for the development of products and services are more and more considered as an organisational capability, which is recognised to be increasingly important for business success in today’s competitive environment. However, management and academia need a more profound understanding of these processes in order to develop improved management approaches to exploit business potentials. This book contains the proceedings of the 3rd International Conference on Modelling and Management of Engineering Processes (MMEP2013) held in Magdeburg, Germany, in November 2013. It includes contributions from international leading researchers in the fields of process modelling and process management. The conference topics were recent trends in modelling and management of engineering processes, potential synergies between different modelling approaches, future challenges for the management of engineering processes as well as future research in these areas.

  14. Quantification of bone mineral density at 3rd lumbar vertebra by dual photon absorptiometry

    International Nuclear Information System (INIS)

    Fukunaga, Masao; Otsuka, Nobuaki; Ono, Shimato; Nagai, Kiyohisa; Muranaka, Akira; Furukawa, Takako; Yanagimoto, Shinichi; Tomomitsu, Tatsushi; Morita, Rikushi

    1987-01-01

    To know bone mineral content of both cortical and spongy bones with aging and pathologic changes, bone mineral density (BMD) in the 3rd lumbar vertebra (L3) and distal radius (DR) was measured using dual photon absorptiometry and single photon absorptiometry, respectively, in 151 normal subjects (N) and four patients with primary hyperparathyroidism (PHP). In the N group, BMD in both L3 and DR decreased with aging. This was more noted, and occurred earlier in L3, irrespective of sex, than DR. In three PHP patients manifested as bone type, BMD was high in L3, and low in DR. Such a tendency was not seen in the remaining one patient with stone type PHP. The findings suggest the need to measure BMD in both cortical (L3) and spongy (DR) bones for elucidating bone pathophysiology in metabolic bone disease. (Namekawa, K.)

  15. 3rd Sino-German Conference “Underground Storage of CO2 and Energy”

    CERN Document Server

    Xie, Heping; Were, Patrick

    2013-01-01

    Anthropogenic greenhouse gas emissions, energy security and sustainability are three of the greatest contemporary global challenges today. This year the Sino-German Cooperation Group “Underground Storage of CO2 and Energy”, is meeting on the 21-23 May 2013 for the second time in Goslar, Germany, to convene its 3rd Sino-German conference on the theme “Clean Energy Systems in the Subsurface: Production, Storage and Conversion”.   This volume is a collection of diverse quality scientific works from different perspectives elucidating on the current developments in CO2 geologic sequestration research to reduce greenhouse emissions including measures to monitor surface leakage, groundwater quality and the integrity of caprock, while ensuring a sufficient supply of clean energy. The contributions herein have been structured into 6 major thematic research themes: Integrated Energy and Environmental Utilization of Geo-reservoirs: Law, Risk Management & Monitoring CO2 for Enhanced Gas and Oil Recovery, Coa...

  16. Analysis of coherence properties of 3-rd generation synchrotron sources and free-electron lasers

    International Nuclear Information System (INIS)

    Vartanyants, I.A.; Singer, A.

    2009-07-01

    A general theoretical approach based on the results of statistical optics is used for the analysis of the transverse coherence properties of 3-rd generation synchrotron sources and X-ray free-electron lasers (XFEL). Correlation properties of the wave elds are calculated at different distances from an equivalent Gaussian Schell-model source. This model is used to describe coherence properties of the five meter undulator source at the synchrotron storage ring PETRA III. In the case of XFEL sources the decomposition of the statistical fields into a sum of independently propagating transverse modes is used for the analysis of the coherence properties of these new sources. A detailed calculation is performed for the parameters of the SASE1 undulator at the European XFEL. It is demonstrated that only a few modes contribute significantly to the total radiation field of that source. (orig.)

  17. Nonlinear Dynamics of Memristor Based 2nd and 3rd Order Oscillators

    KAUST Repository

    Talukdar, Abdul Hafiz

    2011-05-01

    Exceptional behaviours of Memristor are illustrated in Memristor based second order (Wien oscillator) and third order (phase shift oscillator) oscillator systems in this Thesis. Conventional concepts about sustained oscillation have been argued by demonstrating the possibility of sustained oscillation with oscillating resistance and dynamic poles. Mathematical models are also proposed for analysis and simulations have been presented to support the surprising characteristics of the Memristor based oscillator systems. This thesis also describes a comparative study among the Wien family oscillators with one Memristor. In case of phase shift oscillator, one Memristor and three Memristors systems are illustrated and compared to generalize the nonlinear dynamics observed for both 2nd order and 3rd order system. Detail explanations are provided with analytical models to simplify the unconventional properties of Memristor based oscillatory systems.

  18. Idaho National Laboratory Quarterly Occurrence Analysis - 3rd Quarter FY-2016

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (23 from the 3rd Qtr FY-16 and 50 from the prior three reporting quarters), as well as 45 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (16 from this quarter and 29 from the prior three quarters).

  19. [3rd and 4th generation estroprogestatives French controversy: What effect on women's behavior?].

    Science.gov (United States)

    Torres, Luis; Frapard, Christian; Daumas, Aurélie; Guibert, Nicolas; Lagouanelle-Simeoni, Marie-Claude; Rakoto, Jean-Claude; Villani, Patrick; Sambuc, Roland

    2016-04-01

    The primary objective of this study was to determine the reasons given by women who have changed or suspended their contraceptive method in 2013. What influence had the 3rd and 4th generation estroprogestatives (EP) French controversy and advices from doctors? Did they notice any consequences of the controversy on their lifestyle? Did they feel an impact on their behavior to health professionals? A study was conducted on women of childbearing age. Data collection took place between November 4 and December 16, 2013. The included subjects were between 18 and 55 years old females. Subjects were surveyed through an anonymous self-administered questionnaire distributed through pharmacies. The protocol called for the construction of clusters of subjects by having heard about, or not, of the controversy. Patients reporting having heard about the controversy have formed the "exposed" group while the others have formed the "unexposed" group. We compared two parameters between these two groups: the rate of subjects who reported having modified or suspended their contraceptive method in 2013 on one hand, and the rate of subjects who reported having made a change in their contraceptive method without or against advices from a doctor on the other hand. The sample included 988 subjects. The average age was 34 years. The level of exposure to media debates was 86.5%. Of the respondents, 19.8% were under 3rd or 4th generation EP in 2012, thus directly involved in the discussions and affected by health recommendations. Of the patients, 38.5% reported having changed their contraception in 2013. In these women, when they confirmed having heard about the controversy, 40.1% of them claimed to have conducted this process without or against advices from a doctor. This number dropped to 18.2% for those who had not heard of it. Media coverage of the 3rd and 4th generation EP vascular risk was not mentioned more by patients who suspended all medical contraceptive method than it was by

  20. Proceedings of the 3rd workshop on Wendelstein VII-X

    International Nuclear Information System (INIS)

    Rau, F.

    1989-11-01

    This report presents the major part of the information given at the 3rd Workshop on Wendelstein VII-X, held at Schloss Ringberg near Lake Tegernsee, 26-30 June 1989. A number of 9 papers by members of the INTERATOM study group has been summarized. The ongoing work of the development of W VII-X is concentrated on a small number of Helias configurations with five field periods, in order to define their coil systems and the attainable parameter range. This effort aims at a simultaneous realization of the desired numbers of plasma aspect ratio, stability-β, transport, improvement in bootstrap current, etc., in order to arrive at a 'reference configuration' for this experiment. (orig.)

  1. The Perception of Entrepreneurial and 3rd Generation University in Turkey

    Directory of Open Access Journals (Sweden)

    Deniz Zungun

    2016-07-01

    Full Text Available Increased competition caused by globalization has led to philosophical changes in private and public businesses. This situation has affected educational institutions and they have needed dynamic, innovator and transformational tools in order to survive in competitive environment. The universities defined as �3rd Generation Universities� need commercialization, network among universities, close co-operation among institutions and entrepreneurship as well as intellectual and innovative changes. In this regard, the aim of the research is formed by the analysis of �Entrepreneur University� concept from the perspective of the academicians that served at managerial positions at the universities in Turkey. The research is limited to the opinions of the academicians that served at top, middle and lower management at randomly chosen 20 universities.

  2. Handbook on Lead-bismuth Eutectic Alloy and Lead Properties, Materials Compatibility, Thermal-hydraulics and Technologies - 2015 Edition

    International Nuclear Information System (INIS)

    Fazio, Concetta; Sobolev, V.P.; Aerts, A.; Gavrilov, S.; Lambrinou, K.; Schuurmans, P.; Gessi, A.; Agostini, P.; Ciampichetti, A.; Martinelli, L.; Gosse, S.; Balbaud-Celerier, F.; Courouau, J.L.; Terlain, A.; Li, N.; Glasbrenner, H.; Neuhausen, J.; Heinitz, S.; Zanini, L.; Dai, Y.; Jolkkonen, M.; Kurata, Y.; Obara, T.; Thiolliere, N.; Martin-Munoz, F.J.; Heinzel, A.; Weisenburger, A.; Mueller, G.; Schumacher, G.; Jianu, A.; Pacio, J.; Marocco, L.; Stieglitz, R.; Wetzel, T.; Daubner, M.; Litfin, K.; Vogt, J.B.; Proriol-Serre, I.; Gorse, D.; Eckert, S.; Stefani, F.; Buchenau, D.; Wondrak, T.; Hwang, I.S.

    2015-01-01

    Heavy liquid metals such as lead or lead-bismuth have been proposed and investigated as coolants for fast reactors since the 1950's. More recently, there has been renewed interest worldwide in the use of these materials to support the development of systems for the transmutation of radioactive waste. Heavy liquid metals are also under evaluation as a reactor core coolant and accelerator-driven system neutron spallation source. Several national and international R and D programmes are ongoing for the development of liquid lead-alloy technology and the design of liquid lead-alloy-cooled reactor systems. In 2007, a first edition of the handbook was published to provide deeper insight into the properties and experimental results in relation to lead and lead-bismuth eutectic technology and to establish a common database. This handbook remains a reference in the field and is a valuable tool for designers and researchers with an interest in heavy liquid metals. The 2015 edition includes updated data resulting from various national and international R and D programmes and contains new experimental data to help understand some important phenomena such as liquid metal embrittlement and turbulent heat transfer in a fuel bundle. The handbook provides an overview of liquid lead and lead-bismuth eutectic properties, materials compatibility and testing issues, key aspects of thermal-hydraulics and existing facilities, as well as perspectives for future R and D. (authors)

  3. PREFACE: Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors

    Science.gov (United States)

    Granados, Xavier; Sánchez, Àlvar; López-López, Josep

    2012-10-01

    The development of superconducting applications and superconducting engineering requires the support of consistent tools which can provide models for obtaining a good understanding of the behaviour of the systems and predict novel features. These models aim to compute the behaviour of the superconducting systems, design superconducting devices and systems, and understand and test the behavior of the superconducting parts. 50 years ago, in 1962, Charles Bean provided the superconducting community with a model efficient enough to allow the computation of the response of a superconductor to external magnetic fields and currents flowing through in an understandable way: the so called critical-state model. Since then, in addition to the pioneering critical-state approach, other tools have been devised for designing operative superconducting systems, allowing integration of the superconducting design in nearly standard electromagnetic computer-aided design systems by modelling the superconducting parts with consideration of time-dependent processes. In April 2012, Barcelona hosted the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors (HTS), the third in a series of workshops started in Lausanne in 2010 and followed by Cambridge in 2011. The workshop reflected the state-of-the-art and the new initiatives of HTS modelling, considering mathematical, physical and technological aspects within a wide and interdisciplinary scope. Superconductor Science and Technology is now publishing a selection of papers from the workshop which have been selected for their high quality. The selection comprises seven papers covering mathematical, physical and technological topics which contribute to an improvement in the development of procedures, understanding of phenomena and development of applications. We hope that they provide a perspective on the relevance and growth that the modelling of HTS superconductors has achieved in the past 25 years.

  4. World Health Organization classification of tumors of hematopoietic and lymphoid tissues, 4th edition, 2008: major changes from the 3rd edition, 2001

    OpenAIRE

    Zerbini, Maria Claudia Nogueira; Soares, Fernando Augusto; Velloso, Elvira Deolinda Rodrigues Pereira; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP; Paes, Roberto Pinto

    2011-01-01

    A Classificação da Organização Mundial da Saúde (OMS) para os tumores do tecido hematopoético e linfoide (4ª edição, 2008)¹ representa uma atualização da 3ª edição, 2001². Apresentamos a seguir um resumo dessas alterações nos grupos das doenças mieloproliferativas, mileodisplásicas, leucemias mieloides agudas, neoplasias de células precursoras B e T, e neoplasias de células B, T e NK maduras. O entendimento das alterações genético-moleculares e os resultados alcançados com propostas terapêuti...

  5. 3rd International Arab Forensic Sciences & Forensic Medicine Conference, ASFSFM 2017: Conference Report

    Directory of Open Access Journals (Sweden)

    Abdulsallam A. Bakdash

    2017-12-01

    Full Text Available The Arab Society for Forensic Sciences and Forensic Medicine (ASFSFM at Naif Arab University for Security Sciences seeks to present the latest developments in all fields of forensic sciences through holding specialized scientific events and academic activities. This is also achieved through its periodic scientific peer-reviewed journal, the Arab Journal of Forensic Sciences and Forensic Medicine. It also seeks to promote scientific research in all fields of forensic science and forensic medicine, and seeks actively to contribute in holding scientific meetings in accordance with advanced scientific standards, including the 3rd International Arab Forensic Sciences & Forensic Medicine Conference. This important event was attended by scientists and experts from various fields of criminal and forensic sciences from both Arab and non-Arab countries. This conference was a significant scientific accomplishment that contributed to the advancement of forensic sciences and forensic medicine in the Arab world. The conference aimed, in accordance with the vision of Naif Arab University for Security Sciences, to enhance peace, security and justice in Arab societies.  Naif Arab University for Security Sciences, represented by the Arab Society for Forensic Sciences and Forensic Medicine, held the 3rd International Arab Forensic Sciences & Forensic Medicine Conference on the University's campus during the period from 21st to 23rd November 2017. The event included the participation of more than 720 experts in forensic sciences and forensic medicine from 33 countries all over the world. Experts discussed and presented the latest developments in their fields. The conference provided a creative environment for students from both local and international universities to benefit from experts and specialists, and to access the most recent research.  On behalf of His Excellency the president of Naif Arab University for Security Sciences, and the Arab Society for

  6. [Preface for genome editing special issue].

    Science.gov (United States)

    Gu, Feng; Gao, Caixia

    2017-10-25

    Genome editing technology, as an innovative biotechnology, has been widely used for editing the genome from model organisms, animals, plants and microbes. CRISPR/Cas9-based genome editing technology shows its great value and potential in the dissection of functional genomics, improved breeding and genetic disease treatment. In the present special issue, the principle and application of genome editing techniques has been summarized. The advantages and disadvantages of the current genome editing technology and future prospects would also be highlighted.

  7. Orthotics, prosthesis and mobility aids (OPM dispensation in the Regional Health Department of the 3RD Region of Sao Paulo State

    Directory of Open Access Journals (Sweden)

    Camila Caminha Caro

    2014-12-01

    Full Text Available Objective: To identify the process of dispensation of orthotics, prostheses and mobility aids (OPM by the Unified Health System (SUS in the Regional Health Department of the 3rd Region (DRSIII of Sao Paulo state; perform a mapping of the existing physical rehabilitation services in that region; and subsequently correlate the data with applicable laws. Methodology: This is an exploratory cross-sectional qualitative study whose subjects were the main professionals involved in the process of OPM dispensation, or responsible for their acquisition flow in the cities of that region. Data collection was carried out through a semi-structured questionnaire, developed by the researchers themselves, composed of questions aiming to identify the physical rehabilitation centers in the towns, the staff members involved, the provision of assistive technology through SUS, delivery time and existence of waiting lists. Results and discussion: The data were statistically measured, categorized, described and correlated with the current legislation aimed to guarantee access to assistive technology. We observed that the practice around this resource in the 3rd region concentrates in a single care center, causing long waits and poor efficiency of the services provided, in addition to maintaining a paternalistic aspect. Conclusion: This study provides evidence that, although the right to access to assistive technology is legally guaranteed, there are still many difficulties and challenges around this practice.

  8. Regional apparent diffusion coefficient values in 3rd trimester fetal brain

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, Chen [Tel Aviv University, Department of Radiology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Sheba Medical Center, Diagnostic Imaging, 52621, Tel Hashomer (Israel); Weisz, Boaz; Lipitz, Shlomo; Katorza, Eldad [Tel Aviv University, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Yaniv, Gal; Bergman, Dafi [Tel Aviv University, Department of Radiology, Sheba Medical Center, Tel Hashomer (affiliated to the Sackler School of Medicine), Tel Aviv (Israel); Biegon, Anat [Stony Brook University School of Medicine, Department of Neurology, Stony Brook, NY (United States)

    2014-07-15

    Apparent diffusion coefficient (ADC) values in the developing fetus can be used in the diagnosis and prognosis of prenatal brain pathologies. To this end, we measured regional ADC in a relatively large cohort of normal fetal brains in utero. Diffusion-weighted imaging (DWI) was performed in 48 non-sedated 3rd trimester fetuses with normal structural MR imaging results. ADC was measured in white matter (frontal, parietal, temporal, and occipital lobes), basal ganglia, thalamus, pons, and cerebellum. Regional ADC values were compared by one-way ANOVA with gestational age as covariate. Regression analysis was used to examine gestational age-related changes in regional ADC. Four other cases of CMV infection were also examined. Median gestational age was 32 weeks (range, 26-33 weeks). There was a highly significant effect of region on ADC, whereby ADC values were highest in white matter, with significantly lower values in basal ganglia and cerebellum and the lowest values in thalamus and pons. ADC did not significantly change with gestational age in any of the regions tested. In the four cases with fetal CMV infection, ADC value was associated with a global decrease. ADC values in normal fetal brain are relatively stable during the third trimester, show consistent regional variation, and can make an important contribution to the early diagnosis and possibly prognosis of fetal brain pathologies. (orig.)

  9. SESAME-A 3rd Generation Synchrotron Light Source for the Middle East

    Science.gov (United States)

    Winick, Herman

    2010-02-01

    Developed under the auspices of UNESCO and modeled on CERN, SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) is an international research center in construction in Jordan. It will enable world class research by scientists from the region, reversing the brain drain. It will also build bridges between diverse societies, contributing to a culture of peace through international cooperation in science. The centerpiece is a synchrotron light source originating from BESSY I, a gift by Germany. The upgraded machine, a 2.5 GeV 3rd Generation Light Source (133m circumference, 26nm-rad emittance and 12 places for insertion devices), will provide light from infra-red to hard X-rays, offering excellent opportunities to train local scientists and attract those working abroad to return. The SESAME Council meets twice each year and presently has nine Members (Bahrain, Cyprus, Egypt, Iran, Israel, Jordan, Pakistan, Palestinian Authority, Turkey). Members have responsibility for the project and provide the annual operations budget (1.5M US dollars in 2009, expected to rise to about 5M when operation starts in 2012-13). Jordan provided the site, building, and infrastructure. A staff of 20 is installing the 0.8 GeV BESSY I injection system. The facility will have the capacity to serve 30 or more experiments operating simultaneously. See www.sesame.org.jo )

  10. Visual, Critical, and Scientific Thinking Dispositions in a 3rd Grade Science Classroom

    Science.gov (United States)

    Foss, Stacy

    Many American students leave school without the required 21st century critical thinking skills. This qualitative case study, based on the theoretical concepts of Facione, Arheim, and Vygotsky, explored the development of thinking dispositions through the arts in science on the development of scientific thinking skills when used as a conceptual thinking routine in a rural 3rd grade classroom. Research questions examined the disposition to think critically through the arts in science and focused on the perceptions and experiences of 25 students with the Visual Thinking Strategy (VTS) process. Data were collected from classroom observations (n = 10), student interviews (n = 25), teacher interviews ( n = 1), a focus group discussion (n = 3), and artifacts of student work (n = 25); these data included perceptions of VTS, school culture, and classroom characteristics. An inductive analysis of qualitative data resulted in several emergent themes regarding disposition development and students generating questions while increasing affective motivation. The most prevalent dispositions were open-mindedness, the truth-seeking disposition, the analytical disposition, and the systematicity disposition. The findings about the teachers indicated that VTS questions in science supported "gradual release of responsibility", the internalization of process skills and vocabulary, and argumentation. This case study offers descriptive research that links visual arts inquiry and the development of critical thinking dispositions in science at the elementary level. A science curriculum could be developed, that emphasizes the development of thinking dispositions through the arts in science, which in turn, could impact the professional development of teachers and learning outcomes for students.

  11. Medicinal plants profile used by the 3rd District population of Maceió-AL.

    Science.gov (United States)

    Griz, S A S; Matos-Rocha, T J; Santos, A F; Costa, J G; Mousinho, K C

    2017-11-01

    Herein the use of medicinal plants by the population of the 3rd Sanitary District of Maceió-AL city is reported. Transversal description was conducted from February 2013 to January 2014, with a sample of 116 individuals of both Gender Genders aged over 18 years. The ethnobotanical information interviews ethnobotanical information were obtained through semi - structured questionnaire featuring the use of medicinal plants and social and economical data. Descriptive statistics was applied for quantitative variables as mean and standard deviation and proportions for qualitative variables in the frequency table format. The results showed that 85.34% of the interviewees used plants for medicinal purposes. As the majority of these were (73.28%) females in the age group between 30-60 years of old. Among a total of 45 identified plant species, the highest use frequency were for Boldus Peumus (bilberry), Melissa officinalis (lemon balm), and Mentha piperita (mint). The most widely used plant foliage part was (53.53%) prepared as an infusion (55.5%). The use of medicinal plants in Maceió cityis widespread, highlighting the importance of ethnobotanical knowledge for the study of medicinal plants.

  12. The 3^rd International Conference on Women in Physics: Global Perspectives, Common Concerns, Worldwide Views

    Science.gov (United States)

    Zastavker, Yevgeniya V.

    2009-03-01

    The 3^rd International Conference on Women in Physics (ICWIP), held in Seoul, Korea, in October 2008, brought together 300 participants from 57 countries, including a diverse 22-member U.S. Delegation, for a 3-day summit of stimulating discussions, thought-provoking presentations, inspirational posters, and networking. Held under the auspices of the Working Group on Women in Physics of the International Union of Pure and Applied Physics (IUPAP), this meeting built on the successes of the 1^st (Paris, 2002) and 2^nd (Rio de Janeiro, 2005) Conferences and further clarified the importance of diversifying the field of physics worldwide. Although considerable progress has been made since 2002, it was clear that the global scientific workforce is still under-utilizing a large percentage of the available female talent pool. If human society is to benefit to its fullest from various contributions that the field of physics can offer in addressing global issues of economic crisis, energy, environment, water, health, poverty, and hunger, women of all races and nationalities need to become fully included and engaged in the national and international physical community. To address these and many other issues, the ICWIP unanimously approved a five-part resolution to IUPAP recommending actions to promote the recruitment, retention, and advancement of women in physics and related fields.

  13. Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays.

    Science.gov (United States)

    Cavalier, Etienne; Schleck, Marie-Louise; Souberbielle, Jean-Claude

    2018-02-01

    We report here an interference that has been observed with 2 nd generation PTH assays (PTH2), but not with 3 rd generation PTH ones (PTH3), during PTH monitoring occurring in a surgical intervention for the resection of a parathyroid adenoma. The patient was cured and calcium levels returned to normal the next day, but PTH did not decrease with PTH2 whereas it decreased by 50% with PTH3 assays during the intervention. The reason is probably a PTH fragment released by the parathyroid gland during surgery. This fragment possesses the C-terminal part of the peptide but lacks the first amino-acids and may thus be considered as a member of the non-(1-84) PTH fragments family. It has also a longer half-life than 1-84 PTH. To avoid reporting spurious results to the surgeons, we thus recommend using PTH3 assays for monitoring of intra-operative PTH. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Regional apparent diffusion coefficient values in 3rd trimester fetal brain

    International Nuclear Information System (INIS)

    Hoffmann, Chen; Weisz, Boaz; Lipitz, Shlomo; Katorza, Eldad; Yaniv, Gal; Bergman, Dafi; Biegon, Anat

    2014-01-01

    Apparent diffusion coefficient (ADC) values in the developing fetus can be used in the diagnosis and prognosis of prenatal brain pathologies. To this end, we measured regional ADC in a relatively large cohort of normal fetal brains in utero. Diffusion-weighted imaging (DWI) was performed in 48 non-sedated 3rd trimester fetuses with normal structural MR imaging results. ADC was measured in white matter (frontal, parietal, temporal, and occipital lobes), basal ganglia, thalamus, pons, and cerebellum. Regional ADC values were compared by one-way ANOVA with gestational age as covariate. Regression analysis was used to examine gestational age-related changes in regional ADC. Four other cases of CMV infection were also examined. Median gestational age was 32 weeks (range, 26-33 weeks). There was a highly significant effect of region on ADC, whereby ADC values were highest in white matter, with significantly lower values in basal ganglia and cerebellum and the lowest values in thalamus and pons. ADC did not significantly change with gestational age in any of the regions tested. In the four cases with fetal CMV infection, ADC value was associated with a global decrease. ADC values in normal fetal brain are relatively stable during the third trimester, show consistent regional variation, and can make an important contribution to the early diagnosis and possibly prognosis of fetal brain pathologies. (orig.)

  15. Medicinal plants profile used by the 3rd District population of Maceió-AL

    Directory of Open Access Journals (Sweden)

    S. A. S. Griz

    2017-05-01

    Full Text Available Abstract Herein the use of medicinal plants by the population of the 3rd Sanitary District of Maceió-AL city is reported. Transversal description was conducted from February 2013 to January 2014, with a sample of 116 individuals of both Gender Genders aged over 18 years. The ethnobotanical information interviews ethnobotanical information were obtained through semi - structured questionnaire featuring the use of medicinal plants and social and economical data. Descriptive statistics was applied for quantitative variables as mean and standard deviation and proportions for qualitative variables in the frequency table format. The results showed that 85.34% of the interviewees used plants for medicinal purposes. As the majority of these were (73.28% females in the age group between 30-60 years of old. Among a total of 45 identified plant species, the highest use frequency were for Boldus Peumus (bilberry, Melissa officinalis (lemon balm, and Mentha piperita (mint. The most widely used plant foliage part was (53.53% prepared as an infusion (55.5%. The use of medicinal plants in Maceió cityis widespread, highlighting the importance of ethnobotanical knowledge for the study of medicinal plants.

  16. PREFACE: 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015)

    Science.gov (United States)

    Lumban Gaol, Ford; Webb, Jeff; Ding, Jun

    2015-05-01

    The 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015) was held at the Sheraton Kuta, Bali, Indonesia, from 28 - 29 March 2015. The MOIME 2015 conference is aimed to bring together researchers, engineers and scientists in the domain of interest from around the world. MOIME 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that relate to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program, as well as the invited and plenary speakers. This year, we received 99 papers and after rigorous review, 24 papers were accepted. The participants come from eight countries. There were four parallel sessions and two invited speakers. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of MOIME 2015. The Editors of the MOIME 2015 Proceedings Dr. Ford Lumban Gaol Jeff Webb, Ph.D Prof. Jun DING, Ph.D

  17. A history of Ottoman art history through the private database of Edwin Binney, 3rd

    Directory of Open Access Journals (Sweden)

    Keelan Overton

    2012-06-01

    Full Text Available This article examines one of the United States’ greatest art collectors of the mid-twentieth century, Edwin Binney, 3rd (1925–86; specifically, his collection of Ottoman art, which is now divided between the Los Angeles County Museum of Art and Harvard University Art Museums. The most accessible windows into Binney’s world of Ottoman art history and collecting are his four exhibition catalogues on the subject, which accompanied shows held in New York, Los Angeles, and elsewhere. This public legacy is complemented by Binney’s private thoughts on Ottoman art, which he meticulously recorded on the pages of three notebooks now preserved at LACMA. Using Binney’s refreshingly transparent and detailed notes as a primary source, this article traces the development of his Ottoman collection over the course of three decades. In doing so, it introduces the international world of Islamic art collecting c. 1958-84 and raises larger questions pertaining to the formation of collections and canons.

  18. The 3rd international intercomparison on EPR tooth dosimetry: Part 1, general analysis

    International Nuclear Information System (INIS)

    Wieser, A.; Debuyst, R.; Fattibene, P.

    2005-01-01

    The objective of the 3rd International Intercomparison on Electron Paramagnetic Resonance (EPR) Tooth Dosimetry was the evaluation of laboratories performing tooth enamel dosimetry below 300 mGy. Participants had to reconstruct the absorbed dose in tooth enamel from 11 molars, which were cut into two halves. One half of each tooth was irradiated in a 60 Co beam to doses in the ranges of 30-100 mGy (5 samples), 100-300 mGy (5 samples), and 300-900 mGy (1 sample). Fourteen international laboratories participated in this intercomparison programme. A first analysis of the results and an overview of the essential features of methods applied in different laboratories are presented. The relative standard deviation of results of all methods was better than 27% for applied doses in the range of 79-704 mGy. In the analysis of the unirradiated tooth halves 8% of the samples were identified as outliers with additional absorbed dose above background dose

  19. Book Review: Guide to computer forensics and investigations (3rd ed.

    Directory of Open Access Journals (Sweden)

    Keyu Jiang

    2008-09-01

    Full Text Available Nelson, B., Phillips, A., Enfinger, F., & Steuart, C. (2008. Guide to computer forensics and investigations (3rd ed.. New Jersey: Pearson Education, Inc. 693 pages, ISBN: 1-4180-6733-4 (paper.Reviewed by Keyu Jiang (kjiang@fhsu.edu and Ruifeng Xuan (r_xuan@scatcat.fhsu.edu, Department of Information Networking and Telecommunications, Fort Hays State University, Hays, KS 67601Nelson, Phillips, Enfinger, and Steuart’s book is about the science of computer forensics and its implications in crime investigations. This book is not intended to provide comprehensive training in computer forensics, but introduce the science the science of computer forensics and its implications in crime investigations.  It focused on establishing a solid foundation for those who are new to this field.  Nelson, Philips, Enfiger, and Steuart are experienced experts in different areas of computer forensics.  Different expertise makes this book could benefit many groups of people at different educational level and industrial background.(see PDF for full review

  20. [Methodology for an appreciative, dynamic and collaborative process: 3rd Canary Islands (Spain) Health Plan].

    Science.gov (United States)

    O'Shanahan Juan, José Joaquín; Hernández Rodríguez, Miguel Ángel; Del Otero Sanz, Laura; Henríquez Suárez, José Andrés; Mahtani Chugani, Vinita

    The need for new approaches to strategic planning by incorporating the perspectives of professionals and inhabitants has led to a new model for the 3rd Canary Islands (Spain) Health Plan (IIIPSC). A dual-phase participatory process using qualitative techniques is proposed: 1) local phase: a quantitative and qualitative study based on training and a research-action-participation initiative; and 2) insular phase: health conferences with face-to-face discussion of results in each health area (island) and proposals for action. The process prioritises problems and establishes a specific action plan for each island through initiatives that are considered to be viable, grouped by themes and weighted according to the potential impact on priority problems. This process of interaction may help to guide planning model changes and health policy decision-making, and was included in the IIIPSC Project for its parliamentary procedure. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. 3rd International Conference on Energy Equipment Science and Engineering (ICEESE 2017)

    Science.gov (United States)

    2018-03-01

    PREFACE On behalf of the organizing committee of the 2017 3rd International Conference on Energy Equipment Science and Engineering (ICEESE 2017), I would like to express a warm “Thank You” to all the participants, for their important contribution they brought to the Conference! I strongly appreciate the contribution of the authors, who submitted valuable papers and agreed to do successive revisions of their papers, following the recommendations received from the reviewers. ICEESE 2017 was held in Beijing, China during December28-31, 2017, which was organized by Wuhan University and Guizhou Minzu University. The conference provides a useful and wide platform both for display the latest research and for exchange of research results and thoughts in Energy Equipment Science and Engineering. The participants of the conference were from almost every part of the world, with background of either academia or industry, even well-known enterprise. The success and prosperity of the conference is reflected high level of the papers received. List of Committees available in this pdf.

  2. The case of the bold button: Social shaping of technology and the digital scholarly edition

    NARCIS (Netherlands)

    van Zundert, Joris J.

    2016-01-01

    The role and usage of a certain technology is not imparted wholesale on the intended user community—technology is not deterministic. Rather, a negotiation between users and the designers of the technology will result in its particular form and function. This article considers a side effect of these

  3. Energy technology characterizations handbook: Environmental pollution and control factors, third edition

    Science.gov (United States)

    1983-03-01

    Energy technologies and pollution control technologies are reviewed. Technology characterizations are given for the following energy sources: nuclear energy, synthetic fuels, coal, petroleum, natural gas, solar energy, geothermal energy, and hydroelectric energy. Air, water, and solid waste pollution control devices and mechanisms are presented for coal-fired power plants and industrial boilers and for synthetic fuel production from coal and oil shale.

  4. Basics of genome editing technology and its application in livestock species.

    Science.gov (United States)

    Petersen, Bjoern

    2017-08-01

    In the last decade, the research community has witnessed a blooming of targeted genome editing tools and applications. Novel programmable DNA nucleases such as zinc finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs) and the clustered regularly interspaced short palindromic repeats/Cas9 system (CRISPR/Cas9) possess long recognition sites and are capable of cutting DNA in a very specific manner. These DNA nucleases mediate targeted genetic alterations by enhancing the DNA mutation rate via induction of double-strand breaks at a predetermined genomic site. Compared to conventional homologous recombination-based gene targeting, DNA nucleases, also referred to as Genome Editors (GEs), can increase the targeting rate around 10,000- to 100,000-fold. The successful application of different GEs has been shown in a myriad of different organisms, including insects, amphibians, plants, nematodes and several mammalian species, including human cells and embryos. In contrast to all other DNA nucleases, that rely on protein-DNA binding, CRISPR/Cas9 uses RNA to establish a specific binding of its DNA nuclease. Besides its capability to facilitate multiplexed genomic modifications in one shot, the CRISPR/Cas is much easier to design compared to all other DNA nucleases. Current results indicate that any DNA nuclease can be successfully employed in a broad range of organisms which renders them useful for improving the understanding of complex physiological systems such as reproduction, producing transgenic animals, including creating large animal models for human diseases, creating specific cell lines, and plants, and even for treating human genetic diseases. This review provides an update on DNA nucleases, their underlying mechanism and focuses on their application to edit the genome of livestock species. © 2017 Blackwell Verlag GmbH.

  5. Type division and controlling factor analysis of 3rd-order sequences in marine carbonate rocks

    Directory of Open Access Journals (Sweden)

    Yunbo Zhang

    2014-03-01

    Full Text Available Type division and controlling factor analysis of 3rd-order sequence are of practical significance to tectonic analysis, sedimentary environment identification, and other geological researches. Based on the comprehensive analysis of carbon and oxygen isotope trends, paleobathymetry and spectral-frequency of representative well logs, 3rd-order sequences can be divided into 3 types: (a global sea level (GSL sequence mainly controlled by GSL change; (b tectonic sequence mainly controlled by regional tectonic activity; and (c composite sequence jointly controlled by GSL change and regional tectonic activity. This study aims to identify the controlling factors of 3rd-order sequences and to illustrate a new method for classification of 3rd-order sequences of the middle Permian strata in the Sichuan Basin, China. The middle Permian strata in the Sichuan Basin consist of 3 basin-contrastive 3rd-order sequences, i.e., PSQ1, PSQ2 and PSQ3. Of these, PSQ1 is a GSL sequence while PSQ2 and PSQ3 are composite sequences. The results suggest that the depositional environment was stable during the deposition of PSQ1, but was activated by tectonic activity during the deposition of the middle Permian Maokou Formation.

  6. EDITORIAL: Photonica 2011: 3rd International School and Conference on Photonics Photonica 2011: 3rd International School and Conference on Photonics

    Science.gov (United States)

    Petrović, Jovana; Stepić, Milutin; Hadžievski, Ljupčo

    2012-04-01

    Photonics is a rapidly growing discipline of physics that investigates properties of light and its interaction with matter and develops devices based on these properties. Due to both the fundamental and applied nature of photonics research, it pervades many branches of modern technology: quantum mechanics, material science, electronics, telecommunications, biology, medicine, material processing, etc. The borders between these subjects are being erased, generating new research areas such as silicon photonics, biophotonics and quantum photonics. Diverse branches of photonics are united in a common effort to further miniaturize photonic devices, integrate them with existing technologies and develop new technologies. The International School and Conference on Photonics—Photonica—is a biennial forum for the education of young scientists, exchanging new knowledge and ideas, and fostering collaboration between scientists working in photonic science and technology. Conference topics cover a broad range of research activities in optical materials, metamaterials and plasmonics, nonlinear optics, lasers, laser spectroscopy, biophotonics, optoelectronics, optocommunications, photonic crystals, holography, quantum optics and related topics in atomic physics. The aim of the organizers is to provide a platform for discussing new developments, concepts and future trends of various disciplines of photonics by bringing together researchers from academia, government and industrial laboratories. The educational element of Photonica—a series of tutorials and keynote talks—enables students and young researchers to better understand the fundamentals and their use on a route to applications, and informs both young and experienced scientists of new directions of research. The introductory lectures that are directly related to the state-of-the-art are followed by presentations and discussions on recent results during oral and vibrant poster presentations. This Topical Issue is

  7. The 3rd questionnaire report of safety control on instrument in nuclear medicine laboratory

    International Nuclear Information System (INIS)

    1994-01-01

    The present 3rd survey was aimed at grasping safety control in nuclear medicine examination and the trend for SPECT usage. Questionnaires were sent to 1238 facilities dealing with nuclear medicine; and 1127 facilities (91.0%) responded. The survey period was three years from April 1, 1989 through March 31, 1992. The following 7 items were surveyed: (1) nuclear medicine personnel, (2) nuclear medicine equipments, (3) accidents occurring in nuclear medicine laboratories, (4) risk factors leading to accidents, (5) countermeasures for improving safety control, (6) major breakdown of the machinery and equipment, and (7) demands for makers. Majority of nuclear medicine personnel were male and were less than 50 years old. The number of SPECT equipments increased from 714 in the previous survey to 968. Accidents (personal injuries) and narrow escape from an accident were seen in 45 and 154 cases. Personal injuries such as falling occurred in 37 patients and 8 nuclear medicine personnel. According to nuclear medicine examinations, SPECT was the most common examination associated with accident and narrow escape cases (86/199). Such cases at the beginning of examination were remarkably decreased, as compared with those in the previous two surveys. Accidents were primarily attributable to careless management by personnel. Breakdown of the machinery and equipment was reported in 207 cases. In Item 5, the following contents were presented: heads for examination, personnel's behavior, education, examination equipments, collimators and others. Finally, contents in Item 7 included: equipment design, heads for examination, maintenance or management, data processing, collimators, examination equipments and others. (N.K.)

  8. Catalysis in the 3rd Dimension: How Organic Molecules May be Formed

    Science.gov (United States)

    Freund, Friedemann; DeVincenzi, D. (Technical Monitor)

    2001-01-01

    Catalysis is often little more than a word to phenomenologically describe the fact that a reaction follows a pat1 that leads to products of an unexpected kind or of unexpected yield. Low activation energy barriers for intermediates are recognized as the most likely cause why a system deviates from the thermodynamic pull towards minimizing its free energy and ends up in a metastable state. Seldom is the mechanism known. This i: particularly true for heterogeneous catalysis under hydrothermal conditions with minerals as catalysts. It is commonly assumed that catalytic action takes place across solid-fluid interfaces and that, on the atomic level, interfaces are just 2-dimensional contacts. This makes it difficult to understand, for instance, the assembly of long-chain carboxylic (fatty) acids. 3y studying single crystals that grew from a melt in the presence of H2O and CO2, we can show: (1) that numerals take up the fluid components into solid solution, (2) that some-thing happens converting them to -educedH and C, (3) that C atoms segregate into dislocations and tie C-C bonds. The products are medium-to-long chain Cn protomolecules, with some C-H attached, pre-assembled in the dislocations. Upon solvent extraction, these proto-molecules turn into carboxylic and dicarboxylic acids. This observation suggests that, in a very elementary step, catalysis under hydrothermal conditions leading to fatty acids involves the pre-assembly of Cn entities in the interface that is not 2-D but extends into the 3rd dimension, with dislocations as synthesis sites.

  9. Overview of the 3rd phase crossover research on migration of radionuclides in biosphere

    International Nuclear Information System (INIS)

    Uchida, Shigeo; Amano, Hikaru; Chiba, Masaru; Hisamatsu, Shun'ichi; Enomoto, Shuichi; Matsumoto, Shiro

    2003-01-01

    In 1991, we started a series of projects in Nuclear Energy Generic Crossover Research, which is known as ''Crossover Research (CR)''. This 1st phase was successfully finished with the active cooperation of five organizations: Japan Atomic Energy Research Institute (JAERI), Meteorological Research Institute (MRI), National Institute of Radiological Sciences (NIRS), the Institute of Physical and Chemical Research (RIKEN) and Power Reactor and Nuclear Fuel Development Corporation (PNC). Subsequently we carried out the 2nd phase of CR (1996-1998). A new member, Institute for Environmental Sciences (IES) participated from this phase. In the 3rd phase CR, a project on ''Development of a dynamic transfer model of radionuclides in the soil ecosphere'', is currently being promoted (1999-2003). The following five researches are carried out in this project. (1) Research into the forms of existence of nuclide and their change in the soil (NIRS and JAERI), (2) Research into the transition behavior of radionuclides in plants (IES, RIKEN and NIRS), (3) Research into the relation to the microorganism and on environmental remediation (RIKEN, JAERI and NIRS), (4) Research on the migration of radionuclides from atmosphere to soil and plant (MRI and JAERI), and (5) Database construction on transfer parameters (JAERI, NIRS and MRI). Then, JAERI, MRI and NIRS are working on the development of a dynamic transfer model for radionuclides on the basis of a gained knowledge about the environmental behavior with the cooperation of universities, etc. The dynamic transfer model developed in this project is effective not only for Japan, but also for the Southeast Asian countries. Besides, this model is capable of predicting the behavior of materials that are harmful to the environment, i.e. hazardous heavy metals discharged in the soil ecosphere. (author)

  10. On the Generalisation of Kepler's 3rd Law for the Vacuum Field of the Point-Mass

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2005-07-01

    Full Text Available I derive herein a general form of Kepler’s 3rd Law for the general solution to Einstein’s vacuum field. I also obtain stable orbits for photons in all the configurations of the point-mass. Contrary to the accepted theory, Kepler’s 3rd Law is modified by General Relativity and leads to a finite angular velocity as the proper radius of the orbit goes down to zero, without the formation of a black hole. Finally, I generalise the expression for the potential function of the general solution for the point-mass in the weak field.

  11. Federal Technology Alert: Ground-Source Heat Pumps Applied to Federal Facilities--Second Edition

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Donald L.

    2001-03-01

    This Federal Technology Alert, which was sponsored by the U.S. Department of Energy's Office of Federal Energy Management Programs, provides the detailed information and procedures that a Federal energy manager needs to evaluate most ground-source heat pump applications. This report updates an earlier report on ground-source heat pumps that was published in September 1995. In the current report, general benefits of this technology to the Federal sector are described, as are ground-source heat pump operation, system types, design variations, energy savings, and other benefits. In addition, information on current manufacturers, technology users, and references for further reading are provided.

  12. 3rd International School and Conference “Saint Petersburg OPEN 2016” on Optoelectronics, Photonics, Engineering and Nanostructures

    International Nuclear Information System (INIS)

    2016-01-01

    Dear Colleagues, 3rd International School and Conference “Saint Petersburg OPEN 2016” on Optoelectronics, Photonics, Engineering and Nanostructures was held on March 28 - 30, 2016 at St. Petersburg Academic University of the Russian Academy of Sciences. The School and Conference included a series of invited talks given by leading professors with the aim of introducing young scientists to the actual problems and major advances in modern physics and technology. The keynote speakers were Mircea Guina (Tampere University of Technology, Finland) Evgeny I. Terukov (Ioffe Institute RAS, Russia) Victor M. Ustinov (Ioffe Institute RAS, Russia) Peter G. Kazansky (University of Southampton, UK) Alexander O. Golubok (ITMO University, Russia) Georgy E. Cirlin (St Petersburg Academic University RAS, Russia) Levon V. Asryan (Virginia Polytechnic Institute and State University, USA) Andrey A. Lipovskii (Peter the Great St.Petersburg Polytechnic University, Russia) During the poster session all undergraduate and graduate students attending the conference presented their works. A large number of participants with more than 280 student attendees from all over the world allowed the Conference to provide a fertile ground for the fruitful discussions between the young scientists as well as to become a perfect platform for the valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers based on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year “Saint Petersburg OPEN 2016” is organized by St. Petersburg Academic University in cooperation with Peter the Great St. Petersburg Polytechnic University. The School and Conference is supported by the Russian Foundation for Basic Research (Project N 16-32-10060) , Russian Science Foundation, SPIE (The International Society for Optics and Photonics) and OSA (The

  13. 3rd International Conference on Condition Monitoring of Machinery in Non-Stationary Operations

    CERN Document Server

    Rubini, Riccardo; D'Elia, Gianluca; Cocconcelli, Marco; Chaari, Fakher; Zimroz, Radoslaw; Bartelmus, Walter; Haddar, Mohamed

    2014-01-01

    This book presents the processings of the third edition of the Condition Monitoring of Machinery in Non-Stationary Operations (CMMNO13) which was held in Ferrara, Italy. This yearly event merges an international community of researchers who met – in 2011 in Wroclaw (Poland) and in 2012 in Hammamet (Tunisia) – to discuss issues of diagnostics of rotating machines operating in complex motion and/or load conditions. The growing interest of the industrial world on the topics covered by the CMMNO13 involves the fields of packaging, automotive, agricultural, mining, processing and wind machines in addition to that of the systems for data acquisition.The participation of speakers and visitors from industry makes the event an opportunity for immediate assessment of the potential applications of advanced methodologies for the signal analysis. Signals acquired from machines often contain contributions from several different components as well as noise. Therefore, the major challenge of condition monitoring is to po...

  14. 3rd International Workshop on Advances in Simulation-Driven Optimization and Modeling

    CERN Document Server

    Leifsson, Leifur; Yang, Xin-She

    2016-01-01

    This edited volume is devoted to the now-ubiquitous use of computational models across most disciplines of engineering and science, led by a trio of world-renowned researchers in the field. Focused on recent advances of modeling and optimization techniques aimed at handling computationally-expensive engineering problems involving simulation models, this book will be an invaluable resource for specialists (engineers, researchers, graduate students) working in areas as diverse as electrical engineering, mechanical and structural engineering, civil engineering, industrial engineering, hydrodynamics, aerospace engineering, microwave and antenna engineering, ocean science and climate modeling, and the automotive industry, where design processes are heavily based on CPU-heavy computer simulations. Various techniques, such as knowledge-based optimization, adjoint sensitivity techniques, and fast replacement models (to name just a few) are explored in-depth along with an array of the latest techniques to optimize the...

  15. PREFACE: 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS 2012)

    Science.gov (United States)

    Tayurskii, Dmitrii; Abe, Sumiyoshi; Alexandre Wang, Q.

    2012-11-01

    The 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS2012) was held between 25-30 August at Kazan (Volga Region) Federal University, Kazan, Russian Federation. This workshop was jointly organized by Kazan Federal University and Institut Supérieur des Matériaux et Mécaniques Avancées (ISMANS), France. The series of SPMCS workshops was created in 2008 with the aim to be an interdisciplinary incubator for the worldwide exchange of innovative ideas and information about the latest results. The first workshop was held at ISMANS, Le Mans (France) in 2008, and the third at Huazhong Normal University, Wuhan (China) in 2010. At SPMCS2012, we wished to bring together a broad community of researchers from the different branches of the rapidly developing complexity science to discuss the fundamental theoretical challenges (geometry/topology, number theory, statistical physics, dynamical systems, etc) as well as experimental and applied aspects of many practical problems (condensed matter, disordered systems, financial markets, chemistry, biology, geoscience, etc). The program of SPMCS2012 was prepared based on three categories: (i) physical and mathematical studies (quantum mechanics, generalized nonequilibrium thermodynamics, nonlinear dynamics, condensed matter physics, nanoscience); (ii) natural complex systems (physical, geophysical, chemical and biological); (iii) social, economical, political agent systems and man-made complex systems. The conference attracted 64 participants from 10 countries. There were 10 invited lectures, 12 invited talks and 28 regular oral talks in the morning and afternoon sessions. The book of Abstracts is available from the conference website (http://www.ksu.ru/conf/spmcs2012/?id=3). A round table was also held, the topic of which was 'Recent and Anticipated Future Progress in Science of Complexity', discussing a variety of questions and opinions important for the understanding of the concept of

  16. Analyzing Entrepreneurship Skill Levels of the 3rd Grade Primary School Students in Life Sciences Course Based on Different Variables

    Science.gov (United States)

    Polat, Hüseyin

    2018-01-01

    The purpose of this study is to investigate Life Sciences course entrepreneurship skills of the 3rd grade primary school students as evaluated by their parents. The study was conducted with the screening model. The participants of the study were the parents (47 mothers and 23 fathers) of the students (32 girls, 38 boys) who study in the center of…

  17. Visual Arts Teaching in Kindergarten through 3rd-Grade Classrooms in the UAE: Teacher Profiles, Perceptions, and Practices

    Science.gov (United States)

    Buldu, Mehmet; Shaban, Mohamed S.

    2010-01-01

    This study portrayed a picture of kindergarten through 3rd-grade teachers who teach visual arts, their perceptions of the value of visual arts, their visual arts teaching practices, visual arts experiences provided to young learners in school, and major factors and/or influences that affect their teaching of visual arts. The sample for this study…

  18. Renewable Energies and CO2 Cost Analysis, Environmental Impacts and Technological Trends- 2012 Edition

    CERN Document Server

    Guerrero-Lemus, Ricardo

    2013-01-01

    Providing up-to-date numerical data across a range of topics related to renewable energy technologies, Renewable Energies and CO2 offers a one-stop source of key information to engineers, economists and all other professionals working in the energy and climate change sectors. The most relevant up-to-date numerical data are exposed in 201 tables and graphs, integrated in terms of units and methodology, and covering topics such as energy system capacities and lifetimes, production costs, energy payback ratios, carbon emissions, external costs, patents and literature statistics. The data are first presented and then analyzed to project potential future grid, heat and fuel parity scenarios, as well as future technology tendencies in different energy technological areas. Innovative highlights and descriptions of preproduction energy systems and components from the past four years have been gathered from selected journals and international energy departments from G20 countries. As the field develops, readers are in...

  19. PREFACE: 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015)

    Science.gov (United States)

    Gaol, F. L.

    2015-06-01

    The 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015), was held at The Westin Resort Nusa Dua, Bali on 31 January - 1 February 2015. The ScieTech 2015 conference is aimed to bring together researchers, engineers and scientists from around the world. ScieTech 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within mathematics, chemistry and physics. As we already know that science and technology have brought tremendous benefits for human civilization. People are becoming healthier, wealthier, better educated, more peaceful, increasingly connected, and living longer. Of course, science and technology provide many answers to global challenges, but we will face more complex problems in the next decade due to increasing world population, limitation of energy, and climate change. Therefore, researchers should be more active in conducting research that enables collaboration between one and the others. Interdisciplinary cooperation is absolutely necessary in order to create a smart system for solving the global problems. We need a global and general long-term view of the future with long-range goals for solving complex problems in next decade. Therefore the conference was held to be a forum for researchers from different disciplines to start collaborating and conducting research that provides a solution to the global issues. The theme of ScieTech 2015 was ''The interdisciplinary Application between Mathematics, Chemistry and Physics to enhance the Quality of Life''. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting conference program as well as the invited and plenary speakers. This year, we received 197 papers and after rigorous review, 59 papers were accepted. The participants came from 19

  20. 77 FR 72985 - Health Information Technology: Revisions to the 2014 Edition Electronic Health Record...

    Science.gov (United States)

    2012-12-07

    ... technology standards and certification criteria issues. Elizabeth Holland, (410) 786-1309, or Robert Anthony... because QRDA III is a product of several years of industry consensus work. The QRDA III standard has now... use for the first time) would not be able to qualify for the exemption. We explained that the burden...

  1. The Triple Flip: Using Technology for Peer and Self-Editing of Writing

    Science.gov (United States)

    Hojeij, Zeina; Hurley, Zoe

    2017-01-01

    Many teachers consider themselves digital immigrants who struggle to keep up with student digital natives. Whether or not this dichotomy still holds true, in a 21st Century context of teaching and learning, is debatable not least of all because of the exponential development of apps and mobile learning technology. Nevertheless, it is sometimes…

  2. CELEBRATION OF DECEMBER 3RD, INTERNATIONAL DAY OF PERSONS WITH DISABILITIES

    Directory of Open Access Journals (Sweden)

    Maja FILIPOVSKA

    2017-03-01

    Full Text Available On December 2nd 2016 in the main amphitheater at the Faculty of Philosophy in Skopje, was held the celebration of December 3rd, the International Day of Persons with Disabilities, in organization of the Institute of Special Education and Rehabilitation. The official part of the program was started with a speech by Goran Ajdinski, PhD, the Dean of the Faculty of Philosophy in Skopje. The guests at the celebration were also greeted by the Rector of the University “Ss. Cyril and Methodius” – Skopje, Nikola Jankulovski, PhD and the Minister of Labor and Social Policy of Republic of Macedonia, Frosina Tashevska-Remenski, PhD. After the speeches, which highlighted the current efforts and future commitment to inclusion and accessibility of persons with disabilities, two awards were presented by the Humanitarian foundation “Prof. d-r Ljupco Ajdinski”. The first award was given to Simona Kostadinova as the student with achieved highest grade point average of 9.65 in the generation 2011/12 during the studies of Special education and rehabilitation. The second award was intended for the highest ranked student at the university admission in 2016/2017. This award belonged to Nadica Gjerasimova who had 97.70 points on the official rank list. Beside the awards, two acknowledgements for humanity were also given by the Foundation “Prof. d-r Ljupco Ajdinski”. For the longstanding human activity in preparation of special education and rehabilitation staff and education and rehabilitation of persons with disabilities, the first acknowledgement was given to the Institute of Special education and rehabilitation. The second acknowledgement was meant for Kiril Temkov, PhD, about his numerous initiated and organized human activities, especially for the published paper on the ethical dimensions of special education and rehabilitation and introduction of Ethics in the education system in Republic of Macedonia. The last part of the program was intended for

  3. [Research progress in the third-generation genomic editing technology - CRISPR/Cas9].

    Science.gov (United States)

    Zhou, Yalan; Zong, Yanan; Kong, Xiangdong

    2016-10-01

    CRISPR/Cas9 technology originated from type II CRISPR/Cas system, which is widely found in bacteria and equips them with acquired immunity against viruses and plasmids. CRISPR-associated protein Cas9 is a RNA-guided endonuclease, which can efficiently introduce double-strand breaks at specific sites and activate homologous recombination and/or non-homologous end joining mechanism for the repair of impaired DNA. Features such as easy-to-use, cost-effectiveness, multiple targeting ability have made it the third-generation genomic engineering tool following ZFNs and TALENs. Here the history of discovery and molecular mechanism of the CRISPR/Cas9 technology are reviewed. The rapid advance in its various applications, especially for the treatment of human genetic disorders, as well as some concomitant problems are discussed.

  4. Knowledge and institutional requirements to promote land degradation neutrality in drylands - An analysis of the outcomes of the 3rd UNCCD scientific conference

    Science.gov (United States)

    Akhtar-Schuster, Mariam; Safriel, Uriel; Abraham, Elena; de Vente, Joris; Essahli, Wafa; Escadafal, Richard; Stringer, Lindsay

    2015-04-01

    Achieving land degradation neutrality (LDN) through sustainable land management (SLM) targets the maintenance or restoration of the productivity of land, and therefore has to include decision-makers, knowledge generators and knowledge holders at the different relevant geographic scales. In order to enhance the implementation of the Convention, the Conference of the Parties (COP) of the United Nations Convention to Combat Desertification therefore decided that each future session of its Committee on Science and Technology (CST) would be organized in a predominantly scientific and technical conference-style format. This contribution will outline the major outcomes of UNCCD's 3rd scientific conference that will be held in Cancún, Mexico, from 9 to 12 March 2015, on addressing desertification, land degradation and drought issues (DLDD) for poverty reduction and sustainable development. The conference follows an exceptional new round table conference format that will allow the various stakeholders to discuss scientific as well as the contribution of traditional knowledge and practices in combating land degradation. This format should provide two-way communication and enable deeper insight into the availability and contribution of all forms of knowledge for achieving LDN through the assessment of: • the vulnerability of lands to DLDD and climate change and the adaptive capacities of socio-ecosystems; • best examples of adapted, knowledge-based practices and technologies; • monitoring and assessment methods to evaluate the effectiveness of adaptation practices and technologies. The outcomes of UNCCD's 3rd scientific conference will serve as a basis for discussing: • contributions of science to diagnose the status of land; • research gaps that need to be addressed to achieve LDN for poverty reduction; • additional institutional requirements to optimally bridge knowledge generation, knowledge maintenance and knowledge implementation at the science

  5. PREFACE: 3rd International Conference on Geological, Geographical, Aerospace and Earth Science 2015 (AeroEarth 2015)

    Science.gov (United States)

    Gaol, F. L.

    2016-02-01

    The 3rd International Conferences on Geological, Geographical, Aerospaces and Earth Sciences 2015 (AeroEarth 2015), was held at The DoubleTree Hilton, Jakarta, Indonesia during 26 - 27 September 2015. The 1st AeoroEarth was held succefully in Jakarta in 2013. The success continued to The 2nd AeroEarth 2014 that was held in Kuta Bali, Indonesia. The publications were published by EES IOP in http://iopscience.iop.org/1755-1315/19/1 and http://iopscience.iop.org/1755-1315/23/1 respectively. The AeroEarth 2015 conference aims to bring together researchers, engineers and scientists from around the world. Through research and development, Earth's scientists have the power to preserve the planet's different resource domains by providing expert opinion and information about the forces which make life possible on Earth. The theme of AeroEarth 2015 is ''Earth and Aerospace Sciences : Challenges and Opportunities'' Earth provides resources and the exact conditions to make life possible. However, with the advent of technology and industrialization, the Earth's resources are being pushed to the brink of depletion. Non-sustainable industrial practices are not only endangering the supply of the Earth's natural resources, but are also putting burden on life itself by bringing about pollution and climate change. A major role of earth science scholars is to examine the delicate balance between the Earth's resources and the growing demands of industrialization. Through research and development, earth scientists have the power to preserve the planet's different resource domains by providing expert opinion and information about the forces which make life possible on Earth. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 78 papers and after rigorous review, 18 papers were accepted. The participants

  6. Efficient Conversion of Carbon Dioxide into Methane using 3rd Generation Ionic Liquids, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This work directly addresses a technology of interest listed in Section 9, sub-section H1.01 In-Situ Resource Utilization, specifically "Highly efficient reactors...

  7. Methodologies and Intelligent Systems for Technology Enhanced Learning

    CERN Document Server

    Gennari, Rosella; Vittorini, Pierpaolo; Prieta, Fernando

    2015-01-01

    This volume presents recent research on Methodologies and Intelligent Systems for Technology Enhanced Learning. It contains the contributions of MIS4TEL 2015, which took place in Salamanca, Spain,. On June 3rd to 5th 2015. Like the previous edition, this proceedings and the conference is an open forum for discussing intelligent systems for Technology Enhanced Learning and empirical methodologies for their design or evaluation MIS4TEL’15 conference has been organized by University of L’aquila, Free University of Bozen-Bolzano and the University of Salamanca.  .

  8. Neurosurgery. Fourth edition

    International Nuclear Information System (INIS)

    Simon, L.; Thomas, D.G.T.; Clark, W.K.

    1987-01-01

    The Fourth Edition of this volume in the Operative Surgery Series has been considerably revised to accommodate the many changes which have changed the practice of neurosurgery in the past eight years. There have been advances in technology, such as the wider application of CT scanning, in surgical technique, and in the design of new implantable materials. All these developments have substantially affected both the practice of neurosurgery and the prognosis for the patient and are fully reflected in the new edition

  9. Human Germline Genome Editing

    OpenAIRE

    Ormond, Kelly E.; Mortlock, Douglas P.; Scholes, Derek T.; Bombard, Yvonne; Brody, Lawrence C.; Faucett, W. Andrew; Garrison, Nanibaa’ A.; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E.

    2017-01-01

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Gen...

  10. Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.

    Science.gov (United States)

    Newman, Martin; Ausubel, Frederick M

    2016-07-01

    Until very recently, the prospect of introducing mutations or exogenous DNA sequences at precise locations in the genomes of plants and animals was difficult, if not impossible. This rapidly changed with the demonstration that the type II CRISPR-Cas complex, a bacterial anti-viral surveillance system, could be engineered into a simple and robust platform for introducing double-stranded DNA breaks at nearly any position of plant and animal genomes. The prospect of efficiently creating tailored changes to a gene of interest is revolutionizing biomedical research, allowing exciting new questions to be asked. This overview introduces CRISPR-Cas technology as a tool for molecular biology and briefly discusses the advantages of this method over earlier techniques, as well as unique opportunities to create new avenues of research. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

  11. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    OpenAIRE

    Goh, Khoon Song Aloysius; Wee, Loo Kang; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted ...

  12. A Study on the Reading Motivation of Elementary 3rd, 4th, and 5th Grade Students

    OpenAIRE

    Yıldız, Mustafa

    2013-01-01

    Reading motivation can be defined as intrinsic and extrinsic factors that encourage individuals to read. This study focuses on whether elementary level 3rd, 4th, and 5th grade students’ intrinsic and extrinsic reading motivation is affected by the variables of gender and grade level. Being a descriptive survey, the study had 520 participants. The data obtained were analyzed by two-way MANOVA and correlation analysis. The results showed that extrinsic motivation is more effective for the readi...

  13. Differential contribution of specific working memory components to mathematics achievement in 2nd and 3rd graders

    OpenAIRE

    Meyer, M.L.; Salimpoor, V.N.; Wu, S.S.; Geary, D.C.; Menon, V.

    2010-01-01

    The contribution of the three core components of working memory (WM) to the development of mathematical skills in young children is poorly understood. The relation between specific WM components and Numerical Operations, which emphasize computation and fact retrieval, and Mathematical Reasoning, which emphasizes verbal problem solving abilities in 48 2nd and 50 3rd graders was assessed using standardized WM and mathematical achievement measures. For 2nd graders, the central executive and phon...

  14. 1993 Aerospace Avionic Systems Division Conference, 3rd, Denver, CO, Apr. 22, 1993, Proceedings

    Science.gov (United States)

    Topics addressed include a single-supply monolithic, MIL-STD-1553 transreceiver implemented in BiCMOS wafer fabrication technology, a development methodology for contemporary avionics systems, MIL-STD-1553 remote terminal design using ASIC megacell technology, a modular electrooptic bus coupler, experiences in validating MIL-STD-1553 remote terminals, and the STANAG 3910 data bus for the next generation of European avionics systems. Attention is also given to JIAWG compatible development boards for the i960, high-speed databus evaluation, the space avionics architecture standard tailored to the common lunar lander conceptual design, and 1553 RT mechanizations for data sample consistency and multimessage transfers.

  15. Using Inquiry-Based Instructional Strategies to Increase Student Achievement in 3rd Grade Social Studies

    Science.gov (United States)

    McRae-Jones, Wanda Joycelyn

    2017-01-01

    21st Century skills such as critical-thinking and problem-solving skills are very important when it comes to Science Technology Engineering and Mathematics or STEM. But those same skills should be integrated in social studies. The impact of students' learning in social studies as a result of implementing inquiry-based instructional strategies was…

  16. Ethical issues of CRISPR technology and gene editing through the lens of solidarity.

    Science.gov (United States)

    Mulvihill, John J; Capps, Benjamin; Joly, Yann; Lysaght, Tamra; Zwart, Hub A E; Chadwick, Ruth

    2017-06-01

    The avalanche of commentaries on CRISPR-Cas9 technology, a bacterial immune system modified to recognize any short DNA sequence, cut it out, and insert a new one, has rekindled hopes for gene therapy and other applications and raised criticisms of engineering genes in future generations. This discussion draws on articles that emphasize ethics, identified partly through PubMed and Google, 2014-2016. CRISPR-Cas9 has taken the pace and prospects for genetic discovery and applications to a high level, stoking anticipation for somatic gene engineering to help patients. We support a moratorium on germ line manipulation. We place increased emphasis on the principle of solidarity and the public good. The genetic bases of some diseases are not thoroughly addressable with CRISPR-Cas9. We see no new ethical issues, compared with gene therapy and genetic engineering in general, apart from the explosive rate of findings. Other controversies include eugenics, patentability and unrealistic expectations of professionals and the public. Biggest issues are the void of research on human germ cell biology, the appropriate routes for oversight and transparency, and the scientific and ethical areas of reproductive medicine. The principle of genomic solidarity and priority on public good should be a lens for bringing clarity to CRISPR debates. The valid claim of genetic exceptionalism supports restraint on experimentation in human germ cells, given the trans-generational dangers and the knowledge gap in germ cell biology. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  17. Development of human resources through the 3rd WNU Summer Institute

    International Nuclear Information System (INIS)

    Min, B. J.; Kang, H. G.; Shin, J. H.; Lim, S. G.; Lee, A. R.

    2008-01-01

    WNU-SI(World Nuclear University - Summer Institute) is the six-week program designed to develop and inspire future international leaders in the field of nuclear science and technology. In 2007, three Korean young scientists had chances to participate by support of this project. The main purposes in this project are to promote abilities of young Korean nuclear professions, and to build the human network with future leaders in the world-wide nuclear field. The WNU-SI offered an intensive six-week program of lectures, group discussion, field trips, and team projects presented by some of the world's foremost authorities on the global environment and sustainable development, nuclear-related technology innovation, nuclear diplomacy, and nuclear industry operations. The programme is consisted of the following parts. -Lecture -Distinguished Speaker's Presentation -Group Discussion -Case Study -Issue Forum -Technical Tour -Cultural Events Lectures were given by 33 outstanding profession from international organizations, companies, universities and institutes around the world. It covered the wide ranges of subjects from technology to economics and politics. 11 working group were facilitated by Mentors, who are 14 from 8 different countries, to review and discuss about the each lecture subjects. Twice case studies and the issue forum were also main work in working group. The case study is the chance to find the solutions about some specific cases regarding lecture subject. The results was presented and evaluated with all the fellows, mentors and specialists in that field. In the issue forum, the participants selected the subjects they wanted to attend, and proceeded the term project for two weeks after technical tour. This program was one of the highlight in this programme. The final output was presented to the fellows, mentors, and specialists with a final summary report. The following issues were dealt with. -Options for storing radioactive waste -Advantages and

  18. 3rd International Conference on "Emerging Research in Computing, Information, Communication and Applications"

    CERN Document Server

    Prasad, NH; Nalini, N

    2015-01-01

    This proceedings volume covers the proceedings of ERCICA 2015. ERCICA provides an interdisciplinary forum for researchers, professional engineers and scientists, educators, and technologists to discuss, debate and promote research and technology in the upcoming areas of  Computing, Information, Communication and their Applications. The contents of this book cover emerging research areas in fields of Computing, Information, Communication and Applications. This will prove useful to both researchers and practicing engineers.

  19. 3rd congress on applied synthetic biology in Europe (Costa da Caparica, Portugal, February 2016).

    Science.gov (United States)

    Cueva, Miguel

    2017-03-25

    The third meeting organised by the European Federation of Biotechnology (EFB) on advances in Applied Synthetic Biotechnology in Europe (ASBE) was held in Costa da Caparica, Portugal, in February 2016. Abundant novel applications in synthetic biology were described in the six sessions of the meeting, which was divided into technology and tools for synthetic biology (I, II and III), bionanoscience, biosynthetic pathways and enzyme synthetic biology, and metabolic engineering and chemical manufacturing. The meeting presented numerous methods for the development of novel synthetic strains, synthetic biological tools and synthetic biology applications. With the aid of synthetic biology, production costs of chemicals, metabolites and food products are expected to decrease, by generating sustainable biochemical production of such resources. Also, such synthetic biological advances could be applied for medical purposes, as in pharmaceuticals and for biosensors. Recurrent, linked themes throughout the meeting were the shortage of resources, the world's transition into a bioeconomy, and how synthetic biology is helping tackle these issues through cutting-edge technologies. While there are still limitations in synthetic biology research, innovation is propelling the development of technology, the standardisation of synthetic biological tools and the use of suitable host organisms. These developments are laying a foundation to providing a future where cutting-edge research could generate potential solutions to society's pressing issues, thus incentivising a transition into a bioeconomy. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Development of human resources through the 3rd WNU Summer Institute

    Energy Technology Data Exchange (ETDEWEB)

    Min, B. J.; Kang, H. G. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Shin, J. H. [KAIST, Daejeon (Korea, Republic of); Lim, S. G. [Kyunghee University, Seoul (Korea, Republic of); Lee, A. R. [Hanyang University, Seoul (Korea, Republic of)

    2008-01-15

    WNU-SI(World Nuclear University - Summer Institute) is the six-week program designed to develop and inspire future international leaders in the field of nuclear science and technology. In 2007, three Korean young scientists had chances to participate by support of this project. The main purposes in this project are to promote abilities of young Korean nuclear professions, and to build the human network with future leaders in the world-wide nuclear field. The WNU-SI offered an intensive six-week program of lectures, group discussion, field trips, and team projects presented by some of the world's foremost authorities on the global environment and sustainable development, nuclear-related technology innovation, nuclear diplomacy, and nuclear industry operations. The programme is consisted of the following parts. -Lecture -Distinguished Speaker's Presentation -Group Discussion -Case Study -Issue Forum -Technical Tour -Cultural Events Lectures were given by 33 outstanding profession from international organizations, companies, universities and institutes around the world. It covered the wide ranges of subjects from technology to economics and politics. 11 working group were facilitated by Mentors, who are 14 from 8 different countries, to review and discuss about the each lecture subjects. Twice case studies and the issue forum were also main work in working group. The case study is the chance to find the solutions about some specific cases regarding lecture subject. The results was presented and evaluated with all the fellows, mentors and specialists in that field. In the issue forum, the participants selected the subjects they wanted to attend, and proceeded the term project for two weeks after technical tour. This program was one of the highlight in this programme. The final output was presented to the fellows, mentors, and specialists with a final summary report. The following issues were dealt with. -Options for storing radioactive waste -Advantages and

  1. ADTTA '99 - 3rd international conference on accelerator driven transmutation techniques and applications

    International Nuclear Information System (INIS)

    1999-01-01

    The conference dealt with the following topics: (A) Strategy for the back-end of the fuel cycle; (B) National and laboratory research and development programmes and existing collaborations. (C) Activities on collection and improvements of basic nuclear data. (D) Technical aspects of the accelerator part. (E) ADTT targets. (F) Technical aspects of the subcritical reactor part. (G) Reprocessing of fuel based on traditional and advanced technology. (H) Structural materials, developments and testing. (I) Safety aspects of ADTT. (J) Non-proliferation and political aspects. (K) Economic aspects of the closed fuel cycle. (L) Public relations. From among the contributions presented, 128 have been input to INIS. (P.A.)

  2. 3rd Euro-China Conference on Intelligent Data Analysis and Applications

    CERN Document Server

    Snášel, Václav; Sung, Tien-Wen; Wang, Xiao

    2017-01-01

    This book gathers papers presented at the ECC 2016, the Third Euro-China Conference on Intelligent Data Analysis and Applications, which was held in Fuzhou City, China from November 7 to 9, 2016. The aim of the ECC is to provide an internationally respected forum for scientific research in the broad areas of intelligent data analysis, computational intelligence, signal processing, and all associated applications of artificial intelligence (AI). The third installment of the ECC was jointly organized by Fujian University of Technology, China, and VSB-Technical University of Ostrava, Czech Republic. The conference was co-sponsored by Taiwan Association for Web Intelligence Consortium, and Immersion Co., Ltd.

  3. WINRE '92 - 3rd workshop on information management in nuclear safety, radiation protection, and environmental protection

    International Nuclear Information System (INIS)

    Hoepfner, K.A.

    1993-01-01

    The workshop puts much emphasis on the exchange of experience between experts from the West and from the Central and Eastern European countries. The representatives from the various countries and organisations are going to introduce their respective data banks, products, or services. The combination of papers and practical presentations will provide all with a qualified and comprehensive insight into the tried and tested as well as the new information management technologies in the specialist areas of nuclear safety, radiation protection, and environmental protection. Furthermore, it should also contribute to the promotion of the transfer of know-how between experts throughout the whole of Europe. (orig./DG)

  4. 3rd International Workshop on Intelligent Data Analysis and Management (IDAM)

    CERN Document Server

    Wang, Leon; Hong, Tzung-Pei; Yang, Hsin-Chang; Ting, I-Hsien

    2013-01-01

    These papers on Intelligent Data Analysis and Management (IDAM) examine issues related to the research and applications of Artificial Intelligence techniques in data analysis and management across a variety of disciplines. The papers derive from the 2013 IDAM conference in Kaohsiung ,Taiwan. It is an interdisciplinary research field involving academic researchers in information technologies, computer science, public policy, bioinformatics, medical informatics, and social and behavior studies, etc. The techniques studied include (but are not limited to): data visualization, data pre-processing, data engineering, database mining techniques, tools and applications, evolutionary algorithms, machine learning, neural nets, fuzzy logic, statistical pattern recognition, knowledge filtering, and post-processing, etc.

  5. The genome editing revolution

    DEFF Research Database (Denmark)

    Stella, Stefano; Montoya, Guillermo

    2016-01-01

    -Cas system has become the main tool for genome editing in many laboratories. Currently the targeted genome editing technology has been used in many fields and may be a possible approach for human gene therapy. Furthermore, it can also be used to modifying the genomes of model organisms for studying human......In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator-like effector proteins, which are easier to engineer to target new DNA sequences than...... sequence). This ribonucleoprotein complex protects bacteria from invading DNAs, and it was adapted to be used in genome editing. The CRISPR ribonucleic acid (RNA) molecule guides to the specific DNA site the Cas9 nuclease to cleave the DNA target. Two years and more than 1000 publications later, the CRISPR...

  6. Proceedings of the 3rd Annual Albert Institute for Bladder Cancer Research Symposium.

    Science.gov (United States)

    Flaig, Thomas W; Kamat, Ashish M; Hansel, Donna; Ingersoll, Molly A; Barton Grossman, H; Mendelsohn, Cathy; DeGraff, David; Liao, Joseph C; Taylor, John A

    2017-07-27

    The Third Annual Albert Institute Bladder Symposium was held on September 8-10th, 2016, in Denver Colorado. Participants discussed several critical topics in the field of bladder cancer: 1) Best practices for tissue analysis and use to optimize correlative studies, 2) Modeling bladder cancer to facilitate understanding and innovation, 3) Targeted therapies for bladder cancer, 4) Tumor phylogeny in bladder cancer, 5) New Innovations in bladder cancer diagnostics. Our understanding of and approach to treating urothelial carcinoma is undergoing rapid advancement. Preclinical models of bladder cancer have been leveraged to increase our basic and mechanistic understanding of the disease. With the approval of immune checkpoint inhibitors for the treatment of advanced urothelial carcinoma, the treatment approach for these patients has quickly changed. In this light, molecularly-defined subtypes of bladder cancer and appropriate pre-clinical models are now essential to the further advancement and appropriate application of these therapeutic improvements. The optimal collection and processing of clinical urothelial carcinoma tissues samples will also be critical in the development of predictive biomarkers for therapeutic selection. Technological advances in other areas including optimal imaging technologies and micro/nanotechnologies are being applied to bladder cancer, especially in the localized setting, and hold the potential for translational impact in the treatment of bladder cancer patients. Taken together, advances in several basic science and clinical areas are now converging in bladder cancer. These developments hold the promise of shaping and improving the clinical care of those with the disease.

  7. The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models

    Science.gov (United States)

    SHAO, Ming; XU, Tian-Rui; CHEN, Ce-Shi

    2016-01-01

    Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for studying gene function through efficient knock-out, knock-in or chromatin modification of the targeted gene loci in various cell types and organisms. It can be applied in a number of fields, such as genetic breeding, disease treatment and gene functional investigation. In this review, we introduce the most recent developments and applications, the challenges, and future directions of Cas9 in generating disease animal model. Derived from the CRISPR adaptive immune system of bacteria, the development trend of Cas9 will inevitably fuel the vital applications from basic research to biotechnology and biomedicine. PMID:27469250

  8. The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models.

    Science.gov (United States)

    Shao, Ming; Xu, Tian-Rui; Chen, Ce-Shi

    2016-07-18

    Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for studying gene function through efficient knock-out, knock-in or chromatin modification of the targeted gene loci in various cell types and organisms. It can be applied in a number of fields, such as genetic breeding, disease treatment and gene functional investigation. In this review, we introduce the most recent developments and applications, the challenges, and future directions of Cas9 in generating disease animal model. Derived from the CRISPR adaptive immune system of bacteria, the development trend of Cas9 will inevitably fuel the vital applications from basic research to biotechnology and bio-medicine.

  9. 3rd International Conference on Advanced Engineering : Theory and Applications 2016

    CERN Document Server

    Dao, Tran; Kim, Sang; Tien, Nguyen; Zelinka, Ivan

    2017-01-01

    These lecture notes present selected topics concerning a wide range of electrical and electronics applications, highlighting innovative approaches and offering state-of-the-art overviews. The book is divided into 14 topical areas, including e.g. telecommunication, power systems, robotics, control systems, renewable energy, mechanical engineering, computer science and more. Readers will find revealing papers on the design and implementation of control algorithms for automobiles and electrohydraulic systems, efficient protocols for vehicular ad hoc networks and motor control, and energy-saving methods that can be applied in various fields of electrical engineering. The book offers a valuable resource for all practitioners who want to apply the topics discussed to solve real-world problems in their challenging applications. Offering insights into common and related subjects in the research fields of modern electrical, electronic and related technologies, it will also benefit all scientists and engineers working ...

  10. Summary of the 3rd workshop on high power RF-systems for accelerators

    International Nuclear Information System (INIS)

    Sigg, P.K.

    2005-01-01

    The aim of this workshop was to bring together experts from the field of CW and high average power RF systems. The focus was on operational and reliability issues of high-power amplifiers using klystrons and tubes, large power supplies; as well as cavity design and low-level RF and feedback control systems. All these devices are used in synchrotron radiation facilities, high power linacs and collider rings, and cyclotrons. Furthermore, new technologies and their applications were introduced, amongst other: high power solid state amplifiers, IOT amplifiers, and high voltage power supplies employing solid state controllers/crowbars. Numerical methods for complete rf-field modeling of complex RF structures like cyclotrons were presented, as well as integrated RF-cavity designs (electro-magnetic fields and mechanical structure), using numerical methods. (author)

  11. Growing expertise in Africa: CERN-UNESCO's 3rd Digital Library School

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    The third in the series of CERN-UNESCO African Schools on Digital Libraries took place in Dakar, Senegal, in November last year. The School represents an important opportunity for CERN to contribute to a global exchange of knowledge, skills and culture.   Ludmila Marian assisting participants during a hands-on computer session. More photographs available here. After Rwanda and Morocco, this time it was Senegal's turn to host the Digital Library School, the third of its kind, held from 21 to 25 November 2011. Participants from seven African French-speaking countries met at the Université Cheikh Anta Diop in Dakar to learn about digital libraries and the importance of new technologies in the dissemination of knowledge by libraries. The School outlined the principles of digital information management and showcased the Invenio software, developed by CERN to manage digital libraries and freely available as Open Source software. The series of Schools, which combine in...

  12. 3rd International Conference on INformation Systems Design and Intelligent Applications

    CERN Document Server

    Mandal, Jyotsna; Udgata, Siba; Bhateja, Vikrant

    2016-01-01

    The third international conference on INformation Systems Design and Intelligent Applications (INDIA – 2016) held in Visakhapatnam, India during January 8-9, 2016. The book covers all aspects of information system design, computer science and technology, general sciences, and educational research. Upon a double blind review process, a number of high quality papers are selected and collected in the book, which is composed of three different volumes, and covers a variety of topics, including natural language processing, artificial intelligence, security and privacy, communications, wireless and sensor networks, microelectronics, circuit and systems, machine learning, soft computing, mobile computing and applications, cloud computing, software engineering, graphics and image processing, rural engineering, e-commerce, e-governance, business computing, molecular computing, nano-computing, chemical computing, intelligent computing for GIS and remote sensing, bio-informatics and bio-computing. These fields are not...

  13. 3rd symposium on high-efficiency boiler technology: potential, performance, shortcomings of natural gas fuelled high-efficiency boilers

    International Nuclear Information System (INIS)

    1993-01-01

    The brochure contains abstracts of the papers presented at the symposium. The potential, performance and marketing problems of natural gas high-efficiency boiler systems are outlined, and new ideas are presented for gas utilities, producers of appliances, fitters, and chimneysweeps. 13 papers are available as separate regards in this database. (HW) [de

  14. Advanced Technology in Teaching : Proceedings of the 2009 3rd International Conference on Teaching and Computational Science, v.1

    CERN Document Server

    Intelligent Ubiquitous Computing and Education

    2012-01-01

    The volume includes a set of selected papers extended and revised from the International Conference on Teaching and Computational Science (WTCS 2009) held on December 19- 20, 2009, Shenzhen, China.   WTCS 2009 best papers Volume 1 is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of Intelligent Ubiquitous Computing and Education to disseminate their latest research results and exchange views on the future research directions of these fields. 128 high-quality papers are included in the volume. Each paper has been peer-reviewed by at least 2 program committee members and selected by the volume editor Prof.Wu.   On behalf of the WTCS 2009, we would like to express our sincere appreciation to all of authors and referees for their efforts reviewing the papers. Hoping you can find lots of profound research ideas and results on the related fields of Intelligent Ubiquitous Computing and Education.

  15. Advanced Technology in Teaching : Proceedings of the 2009 3rd International Conference on Teaching and Computational Science, v.2

    CERN Document Server

    Education, Psychology and Computer Science

    2012-01-01

    The volume includes a set of selected papers extended and revised from the International Conference on Teaching and Computational Science (WTCS 2009) held on December 19- 20, 2009, Shenzhen, China.   WTCS 2009 best papers Volume 2 is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of Education, Psychology and Computer Science to disseminate their latest research results and exchange views on the future research directions of these fields. 128 high-quality papers are included in the volume. Each paper has been peer-reviewed by at least 2 program committee members and selected by the volume editor Prof. Wu.   On behalf of the WTCS 2009, we would like to express our sincere appreciation to all of authors and referees for their efforts reviewing the papers. Hoping you can find lots of profound research ideas and results on the related fields of Education, Psychology and Computer Science. 

  16. genome editing

    Indian Academy of Sciences (India)

    2016-02-11

    Feb 11, 2016 ... terms in molecular biology, but I have the premonition that we are living a similar event, with identically dra- ... meaning of 'editing' occurred in the French language and in biology. In both cases, computers played ..... Tiegs SL, Russell DM and Nemazee D 1993 Receptor editing in self-reactive bone marrow.

  17. 3rd Quarter Transportation Report FY2015: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis B. [National Security Technologies, LLC (NSTec), Las Vegas, NV (United States)

    2015-07-01

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to and from the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2015 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments.

  18. Turkey's Struggle with Internet in its 3rd year: Don Quixote, Ostrich, Harakiri

    Directory of Open Access Journals (Sweden)

    Mustafa Akgül

    2010-06-01

    Full Text Available The Code 5651 which sets Internet censhorship in Turkey has been active for 3 years. With this lawr, our country twanted to be a leader among democratic countries, , and challenged giant companies like Youtube and Google and fined them with tax penalty. Our country t is trying to set International Law on Internet via code 5651 and decisions of its courts. But it doesn't do this by defending or negotiating the issue on international forums or United Nations. It considers Internet as media and it punishes and bans similar to printing press.. A serious number of people, including the Prime Minister, break the ban. The President of the Republic, State Minister for EU, Minister of Transportation and chairman of Information and Communication Technologies Authority give statements against these bans. In the meantime, rule of law, separation of powers, fair trial, and basic human rights such as freedom of expression are ignored. In other words, a Legal Tradegy occurs in front of lawyers and intellectuals. And our country commits hara-kiri by not understanding Internet, just like the situation in printing machine. In this article, various dimensions of the 3-year struggle of Turkey with Internet are discussed.

  19. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  20. Stages of Geoinformation Evolution Related to the Territories Described in the Bible - from the 3Rd Millennium B.C. to Modern Times

    Science.gov (United States)

    Linsenbarth, Adam

    2012-09-01

    The paper presents consecutive stages of the evolution of geoinformation related to the territories of the events described in the Bible. Two geoinformation sources are presented: the Bible and non-Bible sources. In the Bible there is much, often some highly detailed information regarding terrain topography. The oldest non-Bible sources are incorporated in the ancient documents, which were discovered in Egypt and Mesopotamia. Some of them are related to the 3rd millen- nium B.C. The further stages are related to the onomasticons and itineraries written by travellers and pilgrims to the Holy Land. The most famous onomasticons include: onomasticons prepared by bishop Eusebius from Caesarea and those pre- pared by St. Jerome. One of the oldest maps of Palestine's territory is the so-called mosaic map of Madaba dated to 565. In the 15th century several Bible maps were edited. The most rapid evolution occurred in the 16th and 17* centuries, when the world famous cartographers such as Mercator and Ortelius edited several maps of Palestine's territory. Cartographers from several European countries edited more than 6,000 maps presenting the Biblical territories and Biblical events. Modem maps, based on detailed topographical surveys, were edited m the second half of the 19* and 20th centuries. W artykule przedstawiono kolejne etapy rozwoju geoinformacji dotyczącej terenówr biblijnych. Omówiono dwa źródła informacji, a mianowicie geoinformacje biblijne i pozabiblijne. W tekstach biblijnych można znaleźć wiele, często bardzo detalicznych informacji topograficznych. Najstarsze źródła pozabiblijne, to starożytne dokumenty odnalezione na terenach Egiptu i Mezopotamii. Niektóre z nich pochodzą z trzeciego milenium przed Chr. Kolejnym etapem geoinformacji były onomastikony oraz dzienniki podróży pisane przez podróżników i pielgrzymów do Ziemi Świętej. Do najbardziej znanych należy onomastikon sporządzony przez biskupa Euzebiusza z Cezarei oraz

  1. PREFACE: The 3rd ISESCO International Workshop and Conference On Nanotechnology 2012 (IWCN2012)

    Science.gov (United States)

    Umar, Akrajas Ali; Yahaya, Muhammad; Mat Salleh, Muhamad

    2013-04-01

    The ISESCO Conference on Nanomaterials and Applications (IWCN2012) is one of a series of nanotechnology seminars organized by ISESCO, Malaysian Solid State Science and Technology Society (MASS), the Universiti Kebangsaan Malaysia. IWCN2012 is the third seminar, following IWCN2007 and IWCN2010, held in the Universiti Kebangsaaan Malaysia, Bangi Malaysia from 5-7 December 2012. The conference was attended by more than 250 participants from 15 countries, including 150 students. The conference and workshop provided a forum for researchers and students, policymakers and other professionals especially from the ISESCO Member States to exchange information, enhance understanding and more importantly to engage in the development of new nanoscience and nanotechnology research in multidisciplinary areas in physics, chemistry and biology. Together with the conference, the third Meeting of the ISESCO Expert Panel on Nanotechnology was held to chart the future activities in Nanoscience and Nanotechnology in ISESCO member countries. The objective of the conference is to communicate and discuss recent progress in nanoscience and nanotechnology research and its potential applications in future economic growth. The main focus for the present activity is on energy and environment. The conference received 105 papers in total and 50 of them were selected to be considered for publication in Journal of Physics: Conference Series. However, finally, after undergoing vigorous and thorough revisions by respected editors and reviewers in the fields, 29 papers were accepted. This volume covers the follwing topics: Nanomaterials Synthesis and Characterization Nanomaterials for Energy and Catalysis Nanoelectronics, Sensors and MEMS Devices Nanophotonics We are indebted to all the keynote speakers, invited speakers, participant and authors for their contribution to this event. Their contribution has led to the success of this conference. We are also very grateful for the time, effort and

  2. Differentiation of initial skills in 1st grade and the relative age effect in 3rd grade

    Directory of Open Access Journals (Sweden)

    KRZYSZTOF KONARZEWSKI

    2017-06-01

    Full Text Available The paper aims to verify two hypotheses. The first states that the differentiation of initial 1st grade pupil skills is negatively correlated with age at entry to school. This was tested according to findings from the ERI study Six and seven year olds at the start of school. The variation of reading and writing scores of 1164 pupils aged 5.9–7.9 years who were beginning 1st grade decreased in subsequent age quartiles. The second hypothesis – that classroom differentiation of pupils’ initial skills in 1st grade is positively correlated with the birthdate effect in 3rd grade – was tested on data of 4838 pupils from 254 classrooms drawn from the 2011 PIRLS and TIMSS studies in Poland. Skills were evaluated on the basis of parental reports. Hierarchical linear analysis (gender, SES and school location controlled showed that the greater the differentiation of language skills in 1st grade, the greater the birthdate effect in mathematics in 3rd grade. This result suggests that school entry age is of lesser importance than the methods used to reduce differences in children’s school readiness at the onset of education.

  3. AN ANALYSIS OF STUDENTS’ SPEAKING ABILITY IN ENGLISH CONVERSATION CLUB (ECC PROGRAM AT THE 3rd SEMESTER

    Directory of Open Access Journals (Sweden)

    M. Fadhly Farhy Abbas

    2017-07-01

    Full Text Available This research is based on students’ speaking ability who had followed the EnglishConversation Club (ECC program especially for the third semester of English Department. Thepurpose of this study was to analyze the students’ speaking ability at the 3rd semester in the EnglishConversation Club FKIP UNILAK Pekanbaru. The type of the research was mixed method in typeof explanatory design. The number of participant was 53 students. The researcher used twoinstruments, those were test and interview. In analyzing the data, it used in descriptive statistics.The result of the analysis showed that the average score of 3rd semester students’ speaking abilitywas 45.42. It can be concluded that the students’ speaking ability was categorized into failed . Thescore of Standard Deviation was 7.02, Variance was 49.30, and Range was 36 points . It meansthat the students’ speaking ability was homogeneous. According to the Z-Score, it can be seen that49.06% students’ ability was higher than average and 50.94% students ability was below theaverage. In conclusion, the students’ ability in learning speaking English was failed, it had beenaffected by some factors, those were lack of vocabulary, grammar and motivation. It was supportedby the interview, eventhough the students’ perception to English Conversation Club (ECCprogram was positive, but in fact, the students’ frequency to speak English was seldom, they wereless practice speaking English everyday.Keywords : Speaking , English Conversation Club (ECC

  4. 3rd International Conference on Life Cycle Management. From analysis to implementation

    International Nuclear Information System (INIS)

    Hellweg, S.; Rebitzer, G.

    2007-01-01

    reducing overall environmental impact per unit of resources used (through 'cleaner' technologies and consumption patterns); Substituting currently used resources with better alternatives. The Commission is now implementing different actions to improve decoupling between economic growth and environmental impacts. Sustainable Consumption and Production are essential requirements for a Sustainable Development (SD). The ways in which products, goods and services are delivered to our societies have become increasingly complex and global. Actions taken by designers, producers, their suppliers, consumers, and communities are all interlinked and can affect each other and the global environment. The private sector is a key provider of solutions in this arena. The fundamental role of Business is to create wealth, provide goods and services, create jobs, pay taxes, innovate, invest, improve efficiency and act responsibly. The members of the World Business Council for Sustainable Development have a shared commitment to SD through economic growth, ecological balance and social progress. This initiative concentrates its efforts on leveraging existing reports, documents, training kits and on sharing good practice rather than creating new knowledge

  5. FOREWORD: 3rd Symposium on Large TPCs for Low Energy Event Detection

    Science.gov (United States)

    Irastorza, Igor G.; Colas, Paul; Gorodetzky, Phillippe

    2007-05-01

    The Third International Symposium on large TPCs for low-energy rare-event detection was held at Carré des sciences, Poincaré auditorium, 25 rue de la Montagne Ste Geneviève in Paris on 11 12 December 2006. This prestigious location belonging to the Ministry of Research is hosted in the former Ecole Polytechnique. The meeting, held in Paris every two years, gathers a significant community of physicists involved in rare event detection. Its purpose is an extensive discussion of present and future projects using large TPCs for low energy, low background detection of rare events (low-energy neutrinos, dark matter, solar axions). The use of a new generation of Micro-Pattern Gaseous Detectors (MPGD) appears to be a promising way to reach this goal. The program this year was enriched by a new session devoted to the detection challenge of polarized gamma rays, relevant novel experimental techniques and the impact on particle physics, astrophysics and astronomy. A very particular feature of this conference is the large variety of talks ranging from purely theoretical to purely experimental subjects including novel technological aspects. This allows discussion and exchange of useful information and new ideas that are emerging to address particle physics experimental challenges. The scientific highlights at the Symposium came on many fronts: Status of low-energy neutrino physics and double-beta decay New ideas on double-beta decay experiments Gamma ray polarization measurement combining high-precision TPCs with MPGD read-out Dark Matter challenges in both axion and WIMP search with new emerging ideas for detection improvements Progress in gaseous and liquid TPCs for rare event detection Georges Charpak opened the meeting with a talk on gaseous detectors for applications in the bio-medical field. He also underlined the importance of new MPGD detectors for both physics and applications. There were about 100 registered participants at the symposium. The successful

  6. 3rd Dynamics Days

    CERN Document Server

    Clerc, Marcel

    2016-01-01

    This book presents recent advances, new ideas and novel techniques related to the field of nonlinear dynamics, including localized pattern formation, self-organization and chaos. Various natural systems ranging from nonlinear optics to mechanics, fluids and magnetic are considered. The aim of this book is to gather specialists from these various fields of research to promote cross-fertilization and transfer of knowledge between these active research areas. In particular, nonlinear optics and laser physics constitute an important part in this issue due to the potential applications for all-optical control of light, optical storage, and information processing. Other possible applications include the generation of ultra-short pulses using all-fiber cavities.

  7. 3rd Abel Symposium

    CERN Document Server

    Owren, Brynjulf

    2008-01-01

    The 2006 Abel symposium is focusing on contemporary research involving interaction between computer science, computational science and mathematics. In recent years, computation has been affecting pure mathematics in fundamental ways. Conversely, ideas and methods of pure mathematics are becoming increasingly important within computational and applied mathematics. At the core of computer science is the study of computability and complexity for discrete mathematical structures. Studying the foundations of computational mathematics raises similar questions concerning continuous mathematical structures. There are several reasons for these developments. The exponential growth of computing power is bringing computational methods into ever new application areas. Equally important is the advance of software and programming languages, which to an increasing degree allows the representation of abstract mathematical structures in program code. Symbolic computing is bringing algorithms from mathematical analysis into the...

  8. 3rd SAGA Workshop

    CERN Document Server

    Conti, Giuseppe

    2014-01-01

    Mathematical algorithms are a fundamental component of Computer Aided Design and Manufacturing (CAD/CAM) systems. This book provides a bridge between algebraic geometry and geometric modelling algorithms, formulated within a computer science framework. Apart from the algebraic geometry topics covered, the entire book is based on the unifying concept of using algebraic techniques – properly specialized to solve geometric problems – to seriously improve accuracy, robustness and efficiency of CAD-systems. It provides new approaches as well as industrial applications to deform surfaces when animating virtual characters, to automatically compare images of handwritten signatures, and to improve control of NC machines. This book further introduces a noteworthy representation based on 2D contours, which is essential to model the metal sheet in industrial processes. It additionally reviews applications of numerical algebraic geometry to differential equations systems with multiple solutions and bifurcations. Futur...

  9. 3rd Cryocooler Conference

    CERN Document Server

    Louie, Berverly; McCarthy, Sandy

    1985-01-01

    Cryocoolers 3 documents the output of the Third Cryocooler Conference, held at the National Bureau of Standards, Boulder, Colorado, on September 17-18, 1984. About 140 people from 10 countries attended the conference representing industry, government, and academia. A total of 26 papers were presented orally at the conference and all appear in written form in the proceedings. The focus of this conference was on small cryocoolers in the temperature range of 4 - 80 K. Mechanical and nonmechanical types are discussed in the various papers. Applications of these small cryocoolers include the cooling of infrared detectors, cryopumps, small superconducting devices and magnets, and electronic devices. The conference proceedings reproduced here was published by the National Bureau of Standards in Boulder, Colorado as NBS Special Publication #698.

  10. THE 3rd SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 14-18 APRIL 2012, FLORENCE, ITALY: SUMMARIES OF ORAL SESSIONS

    Science.gov (United States)

    Abbs, Brandon; Achalia, Rashmin M; Adelufosi, Adegoke O; Aktener, Ahmet Yiğit; Beveridge, Natalie J; Bhakta, Savita G; Blackman, Rachael K; Bora, Emre; Byun, MS; Cabanis, Maurice; Carrion, Ricardo; Castellani, Christina A; Chow, Tze Jen; Dmitrzak-Weglarz, M; Gayer-Anderson, Charlotte; Gomes, Felipe V; Haut, Kristen; Hori, Hiroaki; Kantrowitz, Joshua T; Kishimoto, Taishiro; Lee, Frankie HF; Lin, Ashleigh; Palaniyappan, Lena; Quan, Meina; Rubio, Maria D; Ruiz de Azúa, Sonia; Sahoo, Saddichha; Strauss, Gregory P; Szczepankiewicz, Aleksandra; Thompson, Andrew D; Trotta, Antonella; Tully, Laura M; Uchida, Hiroyuki; Velthorst, Eva; Young, Jared W; O’Shea, Anne; DeLisi, Lynn E.

    2013-01-01

    The 3rd Schizophrenia International Research Society Conference was held in Florence, Italy, April 14-18, 2012.and this year had as its emphasis, “The Globalization of Research”. Student travel awardees served as rapporteurs for each oral session and focused their summaries on the most significant findings that emerged and the discussions that followed. The following report is a composite of these summaries. We hope that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:22910407

  11. 3rd Singularity Theory Meeting of Northeast region & the Brazil-Mexico 2nd Meeting on Singularities

    CERN Document Server

    Neto, Aurélio; Mond, David; Saia, Marcelo; Snoussi, Jawad; BMMS 2/NBMS 3; ENSINO; Singularities and foliations geometry, topology and applications

    2018-01-01

    This proceedings book brings selected works from two conferences, the 2nd Brazil-Mexico Meeting on Singularity and the 3rd Northeastern Brazilian Meeting on Singularities, that were hold in Salvador, in July 2015. All contributions were carefully peer-reviewed and revised, and cover topics like Equisingularity, Topology and Geometry of Singularities, Topological Classification of Singularities of Mappings, and more. They were written by mathematicians from several countries, including Brazil, Spain, Mexico, Japan and the USA, on relevant topics on Theory of Singularity, such as studies on deformations, Milnor fibration, foliations, Catastrophe theory, and myriad applications. Open problems are also introduced, making this volume a must-read both for graduate students and active researchers in this field.

  12. Results of the independent verification of radiological remedial action at 196 East 3rd South Street, Monticello, Utah (MS00083)

    International Nuclear Information System (INIS)

    Crutcher, J.W.; Smuin, M.W.

    1989-10-01

    In 1980 the site of a vanadium and uranium mill at Monticello, Utah, was accepted into the US Department of Energy's (DOE) Surplus Facilities Management program with the objectives of restoring the government-owned mill site to safe levels of radioactivity, disposing of or containing the tailings in an environmentally safe manner, and performing remedial actions on off-site (vicinity) properties that had been contaminated by radioactive material resulting from mill operations. During 1984 and 1985, UNC Geotech, the remedial action contractor designated by DOE, performed remedial action on the vicinity property at 196 East 3rd South Street, Monticello, Utah. The Pollutant Assessments Group (PAG) of Oak Ridge National Laboratory was assigned the responsibility of verifying the data supporting the adequacy of remedial action and confirming the site's compliance with DOE guidelines. The PAG found that the site successfully meets the DOE remedial action objectives. Procedures used by PAG are described. 3 refs., 2 tabs

  13. Results of the independent verification of radiological remedial action at 381 East 3rd South Street, Monticello, Utah (MS00140)

    International Nuclear Information System (INIS)

    Crutcher, J.W.; Smuin, M.W.

    1989-10-01

    In 1980 the site of a vanadium and uranium mill at Monticello, Utah, was accepted into the US Department of Energy (DOE's) Surplus Facilities Management Program, with the objectives of restoring the government-owned mill site to safe levels of radioactivity, disposing of or containing the tailings in an environmentally safe manner, and performing remedial actions on off-site (vicinity) properties that had been contaminated by radioactive material resulting from mill operations. During 1986, UNC Geotech, the remedial action contractor designated by DOE, performed remedial action on the vicinity at 381 East 3rd South Street, Monticello, Utah. The Pollutant Assessments group (PAG) of Oak Ridge National Laboratory was assigned the responsibility of verifying the data supporting the adequacy of remedial action and confirming the site's compliance with DOE guidelines. The PAG found that the site successfully meets the DOE remedial action objectives. Procedures used by PAG are described. 3 refs., 2 tabs

  14. Color Portion of Solar Radiation in the Partial Annular Solar Eclipse, October 3rd, 2005, at Helwan, Egypt

    Directory of Open Access Journals (Sweden)

    A. H. Hassan

    2010-01-01

    Full Text Available Measurements were made of various solar radiation components, global, direct and diffuse and their fractions during the partial annular solar eclipse on October 3rd, 2005 at Helwan, Egypt (Lat. 29.866◦ N and Long. 31.20◦ E, and an analysis has been made. The duration of the solar eclipse was 3 h 17 min, and the maximum magnitude of the eclipse in this region was 0.65. The optical depth of the direct component and the relative humidity decreased, while both the transparency and the air temperature increased towards the maximum eclipse. The general trends of the global components are decreasing optical depth and increasing transparency between the first contact and the last contact. The prevailing color during the eclipse duration was diffused infrared (77 % of the total diffuse radiation level.

  15. The Objective Structured Clinical Examination (OSCE) from the perspective of 3rd year's medical students - a pilot study.

    Science.gov (United States)

    Skrzypek, Agnieszka; Szeliga, Marta; Stalmach-Przygoda, Agata; Górski, Stanisław; Kowalska, Bogumiła; Kocurek, Anna; Nowakowski, Michał

    2017-01-01

    In 2015 Department of Medical Education in Medical College of Jagiellonian University in Cracow performed a new format of integrated multidisciplinary skills assessment of third year students of medicine a er completing initial courses in internal medicine, surgery, pediatrics and gynecology. OSCE assessed from the perspective of 3rd year medical students. Students of 3rd year's study of Faculty of medicine were evaluated by OSCE, which assessed their internal medicine, surgery, gynecology, pediatric skills. OSCE consisted of 12 stations. In order to assess student's opinions on OSCE, we used method of diagnostic survey; Statistica 12.0. OSCE passed 255 (98.83%) of the students in thefirst term. We analyzed 221 questionnaires, in which students expressed their opinion. 93.7% of the students considered OSCE as a well organized exam. 87.8% of students claimed that OSCE is fair and 95.5% that the exam is clear. 86.4% students are pleased with the introduction information about OSCE that was given before the examination. 78.6% students believe, that OSCE allows to properly identify skills that require improvement. Students, who didn't pass all stations with positive result, more o en (Chi^2 Pearsona, p = 0.01990) indicated improper balance between quantity of stations that check communication skills and these checking other clinical skills. is study confirms that OSCE in the students' opinions was well organized and fair. It proves that OSCE correctly selects students who need to improve their knowledge and skills. Students' preparing to the exams, their knowledge and skills, influences on the students' perception of OSCE.

  16. Main results on pilot operation during 5 years of the 3rd generation fuel in VVER-440 reactors of Kola NPP

    International Nuclear Information System (INIS)

    Saprykin, V.; Sumarokov, M.; Gagarinskiy, A.; Sumarokova, A.; Adeev, V.

    2015-01-01

    In the report the results of comparison of main neutron-physical data of exploitation of nuclear fuel are presented for the average enrichment (on U - 235) of 4.87 for the 2nd and 3rd (12 piece) generations with the results of calculations by the complex of the programs KASKAD for 5 fuel loadings of Kola NPP Unit 4 with the reactor VVER- 440. The basic feature of fuel of the 3rd generation as compared with the 2nd is a presence of ribs of inflexibility at corners instead of cover of the fuel assembly and also the increased amount of uranium. The arrangement of fuel rods with different enrichment in fuel assemblies of the 2nd and 3rd generations is chosen identical for the convenient comparison of neutronic and thermohydraulic characteristics of the fuel of different generations. The fuel of 3rd generation was situated in the core symmetrically to the fuel of 2nd one

  17. [Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

    Science.gov (United States)

    Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

    2010-01-01

    The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

  18. Editing of the Luteinizing Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Zinc Finger Nuclease Technology with Electroporation.

    Science.gov (United States)

    Qin, Zhenkui; Li, Yun; Su, Baofeng; Cheng, Qi; Ye, Zhi; Perera, Dayan A; Fobes, Michael; Shang, Mei; Dunham, Rex A

    2016-04-01

    Channel catfish (Ictalurus punctatus) is the most important freshwater aquaculture species in the USA. Genetically enhanced fish that are sterile could both profit the catfish industry and reduce potential environmental and ecological risks. As the first step to generate sterile channel catfish, three sets of zinc finger nuclease (ZFN) plasmids targeting the luteinizing hormone (LH) gene were designed and electroporated into one-cell embryos, different concentrations were introduced, and the Cel-I assay was conducted to detect mutations. Channel catfish carrying the mutated LH gene were sterile, as confirmed by DNA sequencing and mating experiments. The overall mutation rate was 19.7 % for 66 channel catfish, and the best treatment was ZFN set 1 at the concentration 25 μg/ml. To our knowledge, this is the first instance of gene editing of fish via plasmid introduction instead of mRNA microinjection. The introduction of the ZFN plasmids may have reduced mosaicism, as mutated individuals were gene edited in every tissue evaluated. Apparently, the plasmids were eventually degraded without integration, as they were not detectable in mutated individuals using PCR. Carp pituitary extract failed to induce spawning and restoration of fertility, indicating the need for developing other hormone therapies to achieve reversal of sterility upon demand. This is the first sterilization achieved using ZFN technology in an aquaculture species and the first successful gene editing of channel catfish. Our results will help understand the roles of the LH gene, purposeful sterilization of teleost fishes, and is a step towards control of domestic, hybrid, exotic, invasive, and transgenic fishes.

  19. Human Germline Genome Editing.

    Science.gov (United States)

    Ormond, Kelly E; Mortlock, Douglas P; Scholes, Derek T; Bombard, Yvonne; Brody, Lawrence C; Faucett, W Andrew; Garrison, Nanibaa' A; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E

    2017-08-03

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Genetic Counselors. These groups, as well as the American Society for Reproductive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Society of Genetic Counselors in Asia, and Southern African Society for Human Genetics, endorsed the final statement. The statement includes the following positions. (1) At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2) Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input. Copyright © 2017 American Society of Human Genetics. All rights reserved.

  20. Cluster editing

    DEFF Research Database (Denmark)

    Böcker, S.; Baumbach, Jan

    2013-01-01

    . The problem has been the inspiration for numerous algorithms in bioinformatics, aiming at clustering entities such as genes, proteins, phenotypes, or patients. In this paper, we review exact and heuristic methods that have been proposed for the Cluster Editing problem, and also applications...

  1. genome editing

    Indian Academy of Sciences (India)

    2016-02-11

    Feb 11, 2016 ... What history tells us. XL. The success story of the expression 'genome editing'. MICHEL MORANGE. Centre Cavaillès, République des Savoirs: Lettres, Sciences, Philosophie USR 3608, Ecole. Normale Supérieure, 29 Rue d'Ulm, 75230, Paris Cedex 05, France. (Fax, 33-144-323941; Email, ...

  2. 3rd Quarter Transportation Report FY 2014: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    International Nuclear Information System (INIS)

    Gregory, Louis

    2014-01-01

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2014 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. This report also includes annual summaries for FY 2014 in Tables 4 and 5. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report do not include minor volumes of non-radioactive materials that were approved for disposal. Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to differing rounding conventions.

  3. Effects of using relaxation breathing training to reduce music performance anxiety in 3rd to 6th graders.

    Science.gov (United States)

    Su, Yu-Huei; Luh, Jer-Junn; Chen, Hsin-I; Lin, Chao-Chen; Liao, Miin-Jiun; Chen, Heng-Shuen

    2010-06-01

    The current study examined the effects of applying relaxation breathing training (RBT) as a means to reduce music performance anxiety (MPA) in young, talented musicians. A group of 59 young musicians from 3rd to 6th grade participated in this study, and all of them started RBT twice a week for 2 months prior to the examination. Four tests--2 mos, 1 mos, half an hour and 5 min before the examination--were conducted to examine the level of MPA after the application of RBT. Results show that the degree of MPA 5 min before the trial was lower than the degree of performance anxiety half an hour before the jury (t = -3.683, p < 0.01), which indicated that the RBT was associated with a decrease in MPA. Although a series of RBT exercises was applied, results indicated that when approaching the date of examination, the degree of performance anxiety still increased and reached its maximum half an hour before the jury. The recommendation for future studies is to combine the application of RBT with other methods to expand its effect in reducing MPA.

  4. From bottom to top: Identification to precision measurement of 3rd-generation quarks with the atlas detector

    Science.gov (United States)

    Sapp, Kevin

    The 3rd-generation quarks, bottom ( b) and top (t), are recent additions to the Standard Model of particle physics, and precise characterization of their properties have important implications to searching for new physics phenomena. This thesis presents two analyses which use 4.6 fb-1 of pp collision data at √s = 7 TeV collected by the ATLAS detector at the Large Hadron Collider (LHC) to measure their properties. The first is an analysis which measures our ability to identify jets originating from b quarks with machine-learning algorithms applied to simulated and real data, so the result in simulation can be corrected to match that in data. This measurement has implications for our ability to identify processes with b quarks in their final state; t quarks decay to a b quark and a weak vector boson W more than 99% of the time. The second analysis presented measures properties of the t → Wb decay channel associated with phenomena not predicted by the Standard Model, through a set of effective couplings which preserve Lorentz covariance. The kinematic information of the final-state particles is used to construct an event-specific coordinate system, and probability density is estimated as a function of solid angle in these coordinates. A parameterization of the effective couplings is extracted via a novel unfolding method, finding their values consistent with the Standard Model expectation, contributing the first measurement of the correlation between the parameters, and improving on previous limits.

  5. The 3rd Canadian Symposium on Hepatitis C Virus: Expanding Care in the Interferon-Free Era

    Directory of Open Access Journals (Sweden)

    Sonya A MacParland

    2014-01-01

    Full Text Available Hepatitis C virus (HCV currently infects approximately 250,000 individuals in Canada and causes more years of life lost than any other infectious disease in the country. In August 2011, new therapies were approved by Health Canada that have achieved higher response rates among those treated, but are poorly tolerated. By 2014/2015, short-course, well-tolerated treatments with cure rates >95% will be available. However, treatment uptake is poor due to structural, financial, geographical, cultural and social barriers. As such, ‘Barriers to access to HCV care in Canada’ is a crucial topic that must be addressed to decrease HCV disease burden and potentially eliminate HCV in Canada. Understanding how to better care for HCV-infected individuals requires integration across multiple disciplines including researchers, clinical services and policy makers to address the major populations affected by HCV including people who inject drugs, baby boomers, immigrants and Aboriginal and/or First Nations people. In 2012, the National CIHR Research Training Program in Hepatitis C organized the 1st Canadian Symposium on Hepatitis C Virus (CSHCV in Montreal, Quebec. The 2nd CSHCV was held in 2013 in Victoria, British Columbia. Both symposia were highly successful, attracting leading international faculty with excellent attendance leading to dialogue and knowledge translation among attendees of diverse backgrounds. The current article summarizes the 3rd CSHCV, held February 2014, in Toronto, Ontario.

  6. Proceedings of the 3rd Expert Consultation and Planning Meeting on Infant and Young Child Nutrition--(Part 2).

    Science.gov (United States)

    Amarra, Sofia; Chan, Pauline

    2013-04-01

    The Infant and Early Childhood Nutrition Task Force, International Life Sciences Institute Southeast Asia (ILSI SEA) Region, organised the 1st and 2nd Expert Consultation and Planning Meeting on Infant and Early Childhood Nutrition in 2009 and 2011, respectively. The goal of the consultations was "to generate and promote relevant science-based information that will help improve nutritional status, growth and development of infants and young children in Southeast Asia." An Expert Panel Core Group was created whose role is to provide advice and recommendations through a review of current scientific knowledge regarding issues related to early childhood growth and nutrition. The Panel is composed of experts representing 7 countries (China, Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam). In July 2012, the Panel convened the 3rd Expert Consultation and Planning Meeting on Infant and Young Child Nutrition in Singapore. This report presents the highlights of the meeting and recommendations made by the Panel on ways to improve infant and young child nutrition in Southeast Asia. The effective use of WHO indicators for assessing infant and young child feeding practices, mitigating the effects of maternal employment on breastfeeding, using behaviour change communication, updating the education of health personnel, and improving maternal health were considered important actions to be taken. Since current feeding practices in Southeast Asia fall short of WHO recommendations, studies are needed to develop strategies which take into consideration the diverse cultural settings that characterise the region.

  7. Ultrastructure of the ovary of Dermatobia hominis (Diptera: cuterebridae. I. Development during the 3rd larval instar

    Directory of Open Access Journals (Sweden)

    E. A. Gregorio

    1990-09-01

    Full Text Available The ultrastructure and distribution of gonial and somatic cells in the ovary of Dermatobia hominis was studied during the 3rd larval instar. In larvae weighing between 400 and 500 mg, the ovary is partially divided into basal and apical regions by oblong somatic cells that penetrate from the periphery; these cells show ovoid nucleus and cytoplasm full of microtubules. In both regions, gonial cells with regular outlines, large nucleus and low electron-density cytoplasm are scattered among the interstitial somatic cells. These later cells have small nucleus and electrodense cytoplasm. Clear somatic cells with small nucleus and cytoplasm of very low electron-density are restrict to the apical region of the gonad. Degenerating interstitial somatic cells are seen in the basal portion close to the ovary peduncle. During all this larval period the morphological features of the ovary remain almost the same. At the end of the period there is a gradual deposition of glycogen in the cytoplasm of the somatic cells, increase in the number and density of their mitochondria plus nuclear modification as membrane wrinkling and chromatin condensation in masses.

  8. 3rd Quarter Transportation Report FY 2014: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2014-09-20

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2014 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. This report also includes annual summaries for FY 2014 in Tables 4 and 5. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report do not include minor volumes of non-radioactive materials that were approved for disposal. Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to differing rounding conventions.

  9. “New” Scythian Complex of the 3rd Century BC on the Right Bank of the Lower Dniester Region

    Directory of Open Access Journals (Sweden)

    Sergey N. Razumov

    2017-09-01

    Full Text Available The article deals with the new attribution of the materials from barrow 20, excavated in 1975 near Semenovka village on the right bank of the Dniester liman, Belgorod-Dnesterovsky district, Odessa region, Ukraine. The only burial of this barrow was still considered as the monument of Babino culture (aka Multi-Cordoned Ware culture of the first quarter of the 2nd millennium BC. The ceramic and metal artifacts found under the barrow were considered during the study of the material culture of the Scythians of the last third of the 1st millennium BC. The thorough analysis of the stratigraphy, planigraphy, funeral rite and artifacts showed that barrow 20 near Semenovka village was built instantaneously, and in fact it is Scythian. A cenotaph was the main complex of the barrow. It came with not only the armament items (iron-socketed arrowheads, spearheads and sockets of spears, horse harness (bronze frontlet with axe-shaped blade and a hook, bronze ringed beads, iron bits and iron snaffle ring, iron round pendants, glass cup, remains of the funeral feast as a ceramic breakage (Rhodes, Sinop, Cos, Cnidus amphorae, two pottery jars and molded vessel, but also with the burial of a dependent person lying crouched on his left side, his head in the eastern sector, in the catacomb. Depth of the fixing of these findings corresponded to the level of the ancient horizon on which the two-sided mainland ejected from the burial construction. Based on the Rhodes amphora marked with the eponym Άγήσιππος of - manufacturer - Έπίγονος 1, the barrow dates back to the last third or last quarter of the 3rd century BC.

  10. Differences in risk factors for 2nd and 3rd degree hypospadias in the National Birth Defects Prevention Study

    Science.gov (United States)

    in 't Woud, Sander Groen; van Rooij, Iris A.L.M.; van Gelder, Marleen M.H.J.; Olney, Richard S.; Carmichael, Suzan L.; Roeleveld, Nel; Reefhuis, Jennita

    2015-01-01

    Background Hypospadias is a frequent birth defect with three phenotypic subtypes. With data from the National Birth Defects Prevention Study, a large, multi-state, population-based, case-control study, we compared risk factors for second and third degree hypospadias. Methods A wide variety of data on maternal and pregnancy-related risk factors for isolated second and third degree hypospadias was collected via computer-assisted telephone interviews to identify potential etiological differences between the two phenotypes. Logistic regression was used to calculate odds ratios including a random effect by study center. Results In total, 1547 second degree cases, 389 third degree cases, and 5183 male controls were included in our study. Third degree cases were more likely to have a non-Hispanic black or Asian/Pacific Islander mother, be delivered preterm, have a low birth weight, be small for gestational age, and be conceived with fertility treatments than second degree cases and controls. Associations with both second and third degree hypospadias were observed for maternal age, family history, parity, plurality, and hypertension during pregnancy. Risk estimates were generally higher for third degree hypospadias except for family history. Conclusions Most risk factors were associated with both or neither phenotype. Therefore, it is likely that the underlying mechanism is at least partly similar for both phenotypes. However, some associations were different between 2nd and 3rd degree hypospadias, and went in opposite directions for second and third degree hypospadias for Asian/Pacific Islander mothers. Effect estimates for subtypes of hypospadias may be over- or underestimated in studies without stratification by phenotype. PMID:25181604

  11. [Level of smoking of 3rd and 4th grade students studying health and related factors: follow-up study].

    Science.gov (United States)

    Göktalay, Tuğba; Cengiz Özyurt, Beyhan; Sakar Coşkun, Ayşin; Celik, Pinar

    2011-01-01

    The levels of smoking of 1st and 2nd year students at Faculty of Medicine and Manisa School of Health at Celal Bayar University were investigated in 2006-2007. This study is carried out in order to see if there is a change in the same students' level of smoking while they are in 3rd and 4th year. In addition, the study aimed to examine the factors affecting the level of use and attitudes towards the law effectuated in July 19, 2009. This is a follow-up study with 80.42% return rate. A 26-item structured questionnaire was administered. The participants filled out the questionnaires under supervision of the researchers in their classrooms. The University Institutional Review Board approved the study. The total of participants (263) of the follow-up study included 189 female and 74 male. The rate of experimenting with smoking was 49% with the mean age of 15.7 (SD= 4.01 years). The mean age of experimenting with smoking was the earliest on male students studying at faculty of medicine. The level of smoking was found to be the most on females, studying at faculty of medicine and staying at the dormitory, with smoking parents (plevel of both experimenting and use of smoking has been increased over time. It is suggested that medical students' awareness about the danger of smoking should be raised at earlier grades. In addition, lectures should be offered to students at School of Health and they should be encouraged to unite in order to fight with smoking.

  12. Association between working time quality and self-perceived health: analysis of the 3rd Korean working conditions survey (2011).

    Science.gov (United States)

    Jung, Jaeyoup; Kim, Gyuree; Kim, Kyusung; Paek, Domyung; Cho, Sung-Il

    2017-01-01

    Self-perceived health, a subjective assessment of one's health condition, is an important health indicator at the level of quality of life. In this study, working time quality refer to job factors with qualitative aspects of working time. This study was conducted to investigate the association between working time quality and self-perceived health in paid workers in Korea. In this study, 35,902 paid workers were analyzed based on the 3rd Korean working conditions survey. For independent variables, working time quality (working at night, working in the evenings, working on Sundays, working on Saturdays, and working more than 10 h a day) were set as major job-related variables. Other occupational characteristics were divided into 6 groups and general characteristics were divided into 6 groups, and univariate analysis was conducted with self-perceived health, a dependent variable. Variables that had significance in the univariate analysis were used for multivariate logistic regression analysis. In the univariate analysis using Chi-square test, variables showing significance in self-perceived health were age, income, education, occupation, employment type, work hours per week, and shift work. Working time quality showed a significant association with self-perceived health. After adjusting for these variables using logistic regression analysis, working at night, working in the evening, working on Sundays, and working more than 10 h a day showed significant association with self-perceived health. This study showed a statistically significant association between working time quality of employees with self-perceived health.

  13. Moving from information and collaboration to action: report from the 3rd International Dog Health Workshop, Paris in April 2017.

    Science.gov (United States)

    O'Neill, Dan G; Keijser, Sylvia F A; Hedhammar, Åke; Kisko, Caroline; Leroy, Gregoire; Llewellyn-Zaidi, Aimée; Malm, Sofia; Olson, Patricia N; Packer, Rowena M A; Rousselot, Jean Francois; Seath, Ian J; Stull, Jason W; Bonnett, Brenda N

    2017-01-01

    Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel clubs, the veterinary profession, welfare scientists, owners, regulators, insurance companies and the media. In reality, all these stakeholders are likely to share some responsibility and optimal progress on resolving these challenges requires all key stakeholders to work together. The International Partnership for Dogs (IPFD), together with an alternating host organization, holds biennial meetings called the International Dog Health Workshops (IDHW). The Société Centrale Canine (French Kennel Club) hosted the 3rd IDHW, in Paris, in April, 2017. These meetings bring together a wide range of stakeholders in dog health, science and welfare to improve international sharing of information and resources, to provide a forum for ongoing collaboration, and to identify specific needs and actions to improve health, well-being and welfare in dogs. The workshop included 140 participants from 23 countries and was structured around six important issues facing those who work to improve dog health. These included individualized breed-specific strategies for health and breeding, extreme conformations, education and communication in relation to antimicrobial resistance, behavior and welfare, genetic testing and population-based evidence. A number of exciting actions were agreed during the meeting. These included setting up working groups to create tools to help breed clubs accelerate the implementation of breed-health strategies, review aspects of extreme conformation and share useful information on behavior. The meeting also heralded the development of an online resource of relevant information describing quality measures for DNA testing. A demand for more and better data and evidence was a recurring message stressed across all themes. The meeting confirmed the benefits from

  14. September 3rd, 2017 underground nuclear test in North Korea: Results from satellite radar imagery and dislocation modeling

    Science.gov (United States)

    Wang, T.; Nikkhoo, M.; Motagh, M.; Wei, S.; Barbot, S.; Burgmann, R.

    2017-12-01

    On September 3rd 2017, two seismic events were detected in the Democratic People's Republic of Korea (North Korea)'s Punggye-ri nuclear test site. US Geological Survey and China Earthquake Networks Center determined a body wave magnitude of Mb 6.3 for the first and larger event. Underground explosions have been well studied using seismic waveforms, the surface displacement associated with this kind of source is, however, poorly known due to the lack of geodetic measurements. Here, we use satellite observations to determine the first-ever complete (3D) surface displacement characterization associated with North Korea's sixth underground nuclear test. We measure the surface displacement by cross-correlating high-resolution radar images (2.5 m in azimuth and 0.5 m in the range direction) acquired by the German TerraSAR-X satellite. We combine azimuth and range offsets from two ascending and two descending tracks to map the 3D surface displacements. The horizontal motions of up to 3.5 m show a divergent pattern centered at the top of Mt. Mantap with a central zone of subsidence of 0.5 m, indicating the surface projection of the source (epicenter). The horizontal motions are distributed asymmetrically with larger displacements on the west and south flanks than the east and north flanks, suggesting a strong topographic control on the surface displacement pattern. We infer the location, depth and geometry of the deformation sources through applying the compound dislocation model (CDM) and the boundary element method (BEM) to the surface displacements. We show that the significant topographic effect on the near field displacements is due to the shallow depth and large radius of the explosion cavity and the steep slopes of the ground zero. The simulated surface displacements in our model consist of the contributions of two consecutive deformation sources, which are represented by two inflating and contracting finite cavities, respectively. The exposed characteristics of the

  15. Genome editing in cardiovascular diseases.

    Science.gov (United States)

    Strong, Alanna; Musunuru, Kiran

    2017-01-01

    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  16. Textiles in a social context. Textile production in Europe and the Mediterranean in the 4th and 3rd millennia BCE (Session report)

    DEFF Research Database (Denmark)

    Siennicka, Malgorzata; Rahmstorf, Lorenz; Ulanowska, Agata

    2015-01-01

    A report of the regular session "Textiles in a social context. Textile production in Europe and the Mediterranean in the 4th and 3rd millennia BCE" at the 20th Annual EAA Conference in Istanbul, Turkey, 10-14/09/2014...

  17. "Elderly Deafblindness." Proceedings of the European Conference of Deafblind International's Acquired Deafblindness Network (3rd, Marcelli di Numana, Italy, October 2-7, 1998).

    Science.gov (United States)

    Deafblind International, London (England).

    This text includes all of the plenary presentations from the 3rd European Conference of Deafblind International's Acquired Deafblindness Network. This international conference was the first to focus specifically on older people with dual sensory impairment. Presentations addressed the awareness of the needs of older people with deafblind or dual…

  18. Approaches to ultra-low radiation dose coronary artery calcium scoring based on 3rd generation dual-source CT : A phantom study

    NARCIS (Netherlands)

    McQuiston, Andrew D.; Muscogiuri, Giuseppe; Schoepf, U. Joseph; Meinel, Felix G.; Canstein, Christian; Varga-Szemes, Akos; Cannao, Paola M.; Wichmann, Julian L.; Allmendinger, Thomas; Vliegenthart, Rozemarijn; De Cecco, Carlo N.

    Objectives: To investigate to what extent 3rd generation dual-source computed tomography (DSCT) can reduce radiation dose in coronary artery calcium scoring. Methods: Image acquisition was performed using a stationary calcification phantom. Prospectively electrocardiogram (ECG)-triggered 120 kV

  19. A significantly lower potency observed for the 3rd WHO International Standard for Parvovirus B19V DNA with the cobas TaqScreen DPX test.

    Science.gov (United States)

    Pisani, G; Cristiano, K; Fabi, S; Simeoni, M; Marino, F; Gaggioli, A

    2016-08-01

    In the context of the Official Medicines Control Laboratories plasma pool testing for Parvovirus B19 DNA, we use the cobas TaqScreen DPX test. When we re-evaluated this method using the 3rd B19 DNA WHO IS at the final concentration of 4 log IU/mL, we observed a titre lower than expected, i.e. 3.79 log IU/mL. Therefore, we further investigated the accuracy of the DPX test. The following B19V DNA materials were tested by using both the DPX test and an in-house real-time PCR: The 1st, 2nd and 3rd WHO ISs for B19V DNA The Non WHO B19V DNA Reference Material for NAT The Biological Reference Preparation B19 virus DNA for NAT testing, batch 1 . The DPX test showed a good accuracy for all B19V DNA materials with the exception of the 3rd WHO IS for B19V DNA. In fact, an underestimation of about 38% was observed for all dilutions of this standard with respect to the nominal titre. With the B19V in-house real-time PCR, all four materials proved to be well calibrated against the 1(st) WHO IS for B19V DNA, used as external standard curve. In this study, we demonstrated that the DPX test underestimates the B19V DNA content of the 3rd WHO IS for B19V DNA and that this is not due to an incorrect potency assigned to the standard but, most probably, to a mismatch between the primers/probe and the sequence of the target region in the 3rd WHO IS for B19V DNA. © 2016 International Society of Blood Transfusion.

  20. ICOM2012: 3rd International Conference on the Physics of Optical Materials and Devices (Belgrade, Serbia, 2-6 September 2012)

    Science.gov (United States)

    Dramićanin, Miroslav D.; Antić, Željka; Viana, Bruno

    2013-11-01

    The 3rd International Conference on the Physics of Optical Materials and Devices (ICOM2012) was held in Belgrade (Serbia) from 2 to 6 September 2012 (figure 1). The conference was organized by the Vinča Institute of Nuclear Sciences, University of Belgrade (Serbia) and the Laboratoire de Chimie de la Matière Condensée de Paris (France), and supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia and Optical Society of America. ICOM2012 was a follow-up to the two previous, successful ICOM conferences held in Herceg Novi in 2006 and 2009. The conference aimed at providing a forum for scientists in optical materials to debate on: • Luminescent materials and nanomaterials • Hybrid optical materials (organic/inorganic) • Characterization techniques of optical materials • Luminescence mechanisms and energy transfers • Theory and modeling of optical processes • Ultrafast-laser processing of materials • Optical sensors • Medical imaging • Advanced optical materials in photovoltaics and biophotonics • Photothermal and photoacoustic spectroscopy and phenomena The conference stressed the value of a fundamental scientific understanding of optical materials. A particular accent was put on wide band-gap materials in crystalline, glass and nanocrystalline forms. The applications mainly involved lasers, scintillators and phosphors. Rare earth and transition metal ions introduced as dopants in various hosts were considered, and their impact on the optical properties were detailed in several presentations. This volume contains selected contributions of speakers and participants of the ICOM2012 conference. The conference provided a unique opportunity for about 200 scientists from 32 countries to discuss recent progress in the field of optical materials. During the three and half days, 21 invited talks and 52 contributed lectures were given, with a special event in memory of our dear colleague Professor Dr Tsoltan

  1. Rapid construction of multiple sgRNA vectors and knockout of the Arabidopsis IAA2 gene using the CRISPR/Cas9 genomic editing technology.

    Science.gov (United States)

    Liu, Ding-yuan; Qiu, Ting; Ding, Xiao-hui; Li, Miao-miao; Zhu, Mu-yuan; Wang, Jun-hui

    2016-08-01

    IAA2 is a member of the Aux/IAA auxin responsive gene family in Arabidopsis thaliana. No iaa2 mutant has been reported until now, thus hindering its further mechanistic investigations. The normal genomic editing technology of CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) uses only a single guide RNA (sgRNA) to target one site in a specific gene, and the gene knockout efficiency is not high. Instead, multiple sgRNAs can target multiple sites; therefore, the efficiency may be improved. In the present investigation, we used the golden-gate cloning strategy and two rounds of PCR reactions to combine three sgRNAs in the same entry vector. The final expression vector was obtained by LR reactions with the destination vector containing the Cas9 expression cassette. Four out of the six sgRNAs were effective, and we also obtained a lot of insertion and deletion mutations. Compared with one sgRNA approach, multiple sgRNAs displayed higher gene-knockout efficiency and produced more germ-line mutants. Thus, we established a more rapid and efficient method and generated five mutants for further studies of IAA2 functions.

  2. Contributions of the National Institute of Nuclear Research to the advance of Science and Technology in Mexico. Commemorative edition 2010

    International Nuclear Information System (INIS)

    Duque M, G.; Jimenez R, M.; Monroy G, F.; Romero H, S.; Serment G, J.

    2010-01-01

    From the second decade of the X X century the applications of the nuclear energy have been important part of the scientific and technological patrimony in Mexico. Records exist with regard to the use of the radioisotopes and the radiations in our country in that time, and in a formal way until the year of 1950, in a process that culminates with the creation of the Comision Nacional de Energia Nuclear (CNEN. January 1, 1956). In January 12, 1972 were published the Organic Law that created to the Instituto Nacional de Energia Nuclear, being responsible for the works that the CNEN developed. The current Instituto Nacional de Investigaciones Nucleares (ININ) was constituted starting from the Regulation Law of the constitutional Article 27 in nuclear matter of January 26, 1979, abrogated and substituted by the Law in force of February 4, 1985. In this lapse they were undertaken multitude of projects with results and diverse achievements. From their creation, the mission of the ININ and the previous institutions has been to realize research in science and nuclear technology, to promote their peaceful uses and to diffuse the achieved advances, always searching for to link them to the economic, social, scientific and technological development of the country. In this occasion with the purpose of participating in the commemoration of the bicentennial of the independence and centennial of the Mexican revolution in our country, the ININ decided to publish this work, directed to a wide public, with the intention of providing a vision the most complete and appropriate possible of the activities in research and technology that it is carries out at the moment. This work also seeks to be a diffusion instrument of the tasks that they are carried out in the institute, in diverse subjects as: the basic research, the nuclear applications in the health, the agriculture and the industry, the studies on the contamination and the environment; the dosimetry; the radiological protection; as

  3. Proceedings of the 3rd World Congress on Integrated Computational Materials Engineering (ICME 2015). Held in Colorado Springs, CO on May 31-June 4, 2015

    Science.gov (United States)

    2016-06-28

    papers in PDF format are available at http://onlinelibrary.wiley.com. By way of example, some select papers from the ICME 3rd World Congress Proceedings...Integrated Computational N000141512537 Materials Engineering ( ICME 2015) 5b. GRANT NUMBER N000141512537 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...Computational Materials Engineering ( ICME ) has received international attention due to its great potential to shorten product and process development

  4. The 3rd CARISMA international conference on medium and high temperature proton exchange membrane fuel cells: Three approaches to better platinum catalysts at biannual conference

    DEFF Research Database (Denmark)

    Jensen, Jens Oluf; Cleemann, Lars Nilausen; Li, Qingfeng

    2013-01-01

    The 3rd CARISMA International Conference was held at the Axelborg venue in Copenhagen, Denmark, from September 3-5, 2012. The CARISMA conference series was specifically devoted to challenges in the development and testing of fuel cell materials and membrane electrode assemblies (MEAs) for proton ...... 150 participants from 20 countries in five continents. The majority of the audience was academic or from research organizations, along with industrial representatives from 20 companies....

  5. Medical students’ skills in image interpretation before and after training: A comparison between 3rd-year and 6th-year students from two different medical curricula

    International Nuclear Information System (INIS)

    Sendra-Portero, Francisco; Torales-Chaparro, Oscar E.; Ruiz-Gómez, Miguel J.

    2012-01-01

    The purpose of this study was to assess student's performance in the interpretation of images before and after training in radiology, by comparing two groups, 6th-year and 3rd-year students, from two different medical curricula. Students participated in an anonymous evaluation consisting of the interpretation of 12 radiological images accompanied with the salient history and clinical data by answering 60 open-ended questions about technique, anatomy, semiology, and clinics. The number of correct, incorrect and blank responses of each group was used to compare pre- and post-training results. Unpaired two-sample t-test was used to evaluate differences between groups. A significant increase in correct responses was found in both groups after training. The comparison between both groups did not show differences for incorrect answers of the whole test and correct answers about anatomy in the pre-training evaluation. The percentage of correct answers to the median question improved from 15.5% to 53.3% for 6th-year students and from 8.3% to 41.1% for 3rd-year students. The post-training evaluation showed a significant increase of correct answers of 6th-year students with respect to 3rd-year students (mean ± standard deviation 53.6 ± 31.3% and 38.7 ± 29.9% respectively), mainly due to differences in technical and clinical questions. This study provides objective and quantitative evidence of pre- and post-training student skills in image interpretation. The similarities found in the previous level of knowledge and skills of both groups emphasizes the suitable change of the first-time training in radiology, from the 6th to the 3rd year course in medical curricula.

  6. Medical students’ skills in image interpretation before and after training: A comparison between 3rd-year and 6th-year students from two different medical curricula

    Energy Technology Data Exchange (ETDEWEB)

    Sendra-Portero, Francisco, E-mail: sendra@uma.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain); Torales-Chaparro, Oscar E., E-mail: oetjft@terra.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain); Ruiz-Gómez, Miguel J., E-mail: mjrg@uma.es [Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, Boulevar Louis Pasteur, 32, 29071 Málaga (Spain)

    2012-12-15

    The purpose of this study was to assess student's performance in the interpretation of images before and after training in radiology, by comparing two groups, 6th-year and 3rd-year students, from two different medical curricula. Students participated in an anonymous evaluation consisting of the interpretation of 12 radiological images accompanied with the salient history and clinical data by answering 60 open-ended questions about technique, anatomy, semiology, and clinics. The number of correct, incorrect and blank responses of each group was used to compare pre- and post-training results. Unpaired two-sample t-test was used to evaluate differences between groups. A significant increase in correct responses was found in both groups after training. The comparison between both groups did not show differences for incorrect answers of the whole test and correct answers about anatomy in the pre-training evaluation. The percentage of correct answers to the median question improved from 15.5% to 53.3% for 6th-year students and from 8.3% to 41.1% for 3rd-year students. The post-training evaluation showed a significant increase of correct answers of 6th-year students with respect to 3rd-year students (mean ± standard deviation 53.6 ± 31.3% and 38.7 ± 29.9% respectively), mainly due to differences in technical and clinical questions. This study provides objective and quantitative evidence of pre- and post-training student skills in image interpretation. The similarities found in the previous level of knowledge and skills of both groups emphasizes the suitable change of the first-time training in radiology, from the 6th to the 3rd year course in medical curricula.

  7. Food Micro 2010, 22th International ICFMH Symposium, “ Microbial Behaviour in the Food Chain ” 30th August – 3rd September 2010, Copenhagen, Denmark

    DEFF Research Database (Denmark)

    2012-01-01

    This Special Issue of International Journal of Food Microbiology contains a selection of papers presented at Food Micro 2010, the 22th Symposium of the International Committee on Food Microbiology and Hygiene (ICFMH). Food Micro 2010 was held on 30th August to 3rd September 2010 in Copenhagen......, Denmark and organized in collaboration between the Danish Centre for Advanced Food Studies (LMC) and Lund University in Sweden....

  8. Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

    OpenAIRE

    Lewis, Cara; Darnell, Doyanne; Kerns, Suzanne; Monroe-DeVita, Maria; Landes, Sara J.; Lyon, Aaron R.; Stanick, Cameo; Dorsey, Shannon; Locke, Jill; Marriott, Brigid; Puspitasari, Ajeng; Dorsey, Caitlin; Hendricks, Karin; Pierson, Andria; Fizur, Phil

    2016-01-01

    Table of contents Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective ...

  9. The construction of the CMS electromagnetic calorimeter: delivery of the 3rd and 4th endcap "Dees" and Ring Flanges to CERN

    CERN Multimedia

    2006-01-01

    Delivery of the 3rd and 4th Dees and Ring Flanges of the CMS-ECAL endcaps to CERN. The pictures show also an endcap crystal with its VPT (Vacuum PhotoTriode), the aluminium blackplates of the endcap Dees and four mock supercrystals (5x5 crystals) attached in their position on the backplate, along with 138 positional spacers. Finally, endcap assembly in the CMS construction hall in Cessy (neighbouring France) is also shown.

  10. Gene editing. Time to reflection.

    OpenAIRE

    Santaló Pedro, Josep

    2017-01-01

    The development of new gene editing technologies and their special characteristics have led to a passionate debate on the suitability and reliability of their use both in plant and animal species and in the human species itself. A brief analysis of the arguments used in this debate as well as a summary of some of the most relevant statements in this regard is made.

  11. 3rd harmonic electron cyclotron resonant heating absorption enhancement by 2nd harmonic heating at the same frequency in a tokamak

    International Nuclear Information System (INIS)

    Gnesin, S; Coda, S; Goodman, T P; Decker, J; Peysson, Y; Mazon, D

    2012-01-01

    The fundamental mechanisms responsible for the interplay and synergy between the absorption dynamics of extraordinary-mode electron cyclotron waves at two different harmonic resonances (the 2nd and 3rd) are investigated in the TCV tokamak. An enhanced 3rd harmonic absorption in the presence of suprathermal electrons generated by 2nd harmonic heating is predicted by Fokker–Planck simulations, subject to complex alignment requirements in both physical space and momentum space. The experimental signature for the 2nd/3rd harmonic synergy is sought through the suprathermal bremsstrahlung emission in the hard x-ray range of photon energy. Using a synthetic diagnostic, the emission variation due to synergy is calculated as a function of the injected power and of the radial transport of suprathermal electrons. It is concluded that in the present experimental setup a synergy signature has not been unambiguously detected. The detectability of the synergy is then discussed with respect to variations and uncertainties in the plasma density and effective charge in view of future optimized experiments. (paper)

  12. Sustainability in Energy and Buildings : Proceedings of the 3rd International Conference in Sustainability in Energy and Buildings

    CERN Document Server

    Namaane, Aziz; Howlett, Robert; Jain, Lakhmi

    2012-01-01

    Welcome to the proceedings of the Third International Conference on Sustainability in Energy and Buildings, SEB’11, held in Marseilles in France, organised by the Laboratoire des Sciences del'Information et des Systèmes (LSIS) in Marseille, France in partnership with KES International.   SEB'11 formed a welcome opportunity for researchers in subjects related to sustainability, renewable energy technology, and applications in the built environment to mix with other scientists, industrialists and stakeholders in the field.   The conference featured presentations on a range of renewable energy and sustainability related topics. In addition the conference explored two innovative themes: - the application of intelligent sensing, control, optimisation and modelling techniques to sustainability and - the technology of sustainable buildings.  These two themes combine synergetically to address issues relating to The Intelligent Building.   SEB’11 attracted a significant number of submissions from around the w...

  13. Book of abstracts: 3rd International Conference on Smart Energy Systems and 4th Generation District Heating

    DEFF Research Database (Denmark)

    everyone for your valuable contributions. The aim is to present and discuss scientific findings and industrial experiences related to the development of Smart Energy Systems and future 4th Generation District Heating Technologies and Systems (4GDH). This development is fundamental to the implementation....... The Smart Energy System concept is essential for 100% renewable energy systems to harvest storage synergies and exploit low-value heat sources. The most effective and least-cost solutions are to be found when the electricity sector is combined with the heating and cooling sectors and/or the transport sector....... Moreover, the combination of electricity and gas infrastructures may play an important role in the design of future renewable energy systems. In its research on low-temperature district heating, the Strategic Research Centre for 4th Generation District Heating Technologies and Systems enhances...

  14. Beginning XML, 5th Edition

    CERN Document Server

    Fawcett, Joe; Quin, Liam R E

    2012-01-01

    A complete update covering the many advances to the XML language The XML language has become the standard for writing documents on the Internet and is constantly improving and evolving. This new edition covers all the many new XML-based technologies that have appeared since the previous edition four years ago, providing you with an up-to-date introductory guide and reference. Packed with real-world code examples, best practices, and in-depth coverage of the most important and relevant topics, this authoritative resource explores both the advantages and disadvantages of XML and addresses the mo

  15. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies.

    Science.gov (United States)

    Wang, Gang; Yang, Luhan; Grishin, Dennis; Rios, Xavier; Ye, Lillian Y; Hu, Yong; Li, Kai; Zhang, Donghui; Church, George M; Pu, William T

    2017-01-01

    Genome editing of human induced pluripotent stem cells (hiPSCs) offers unprecedented opportunities for in vitro disease modeling and personalized cell replacement therapy. The introduction of Cas9-directed genome editing has expanded adoption of this approach. However, marker-free genome editing using standard protocols remains inefficient, yielding desired targeted alleles at a rate of ∼1-5%. We developed a protocol based on a doxycycline-inducible Cas9 transgene carried on a piggyBac transposon to enable robust and highly efficient Cas9-directed genome editing, so that a parental line can be expeditiously engineered to harbor many separate mutations. Treatment with doxycycline and transfection with guide RNA (gRNA), donor DNA and piggyBac transposase resulted in efficient, targeted genome editing and concurrent scarless transgene excision. Using this approach, in 7 weeks it is possible to efficiently obtain genome-edited clones with minimal off-target mutagenesis and with indel mutation frequencies of 40-50% and homology-directed repair (HDR) frequencies of 10-20%.

  16. Basic Wiring. Third Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Kaltwasser, Stan; Flowers, Gary; Blasingame, Don; Batson, Larry; Ipock, Dan; Carroll, Charles; Friesen, Wade; Fleming, Glenn

    This publication contains both a teacher edition and a student edition of materials for a foundation course in an electrical wiring program. The course introduces basic concepts and skills that are prerequisites to residential wiring and commercial and industrial wiring courses. The contents of the materials are tied to measurable and observable…

  17. [Genome editing of industrial microorganism].

    Science.gov (United States)

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  18. Wikipedia editing dynamics

    Science.gov (United States)

    Gandica, Y.; Carvalho, J.; Sampaio dos Aidos, F.

    2015-01-01

    A model for the probabilistic function followed in editing Wikipedia is presented and compared with simulations and real data. It is argued that the probability of editing is proportional to the editor's number of previous edits (preferential attachment), to the editor's fitness, and to an aging factor. Using these simple ingredients, it is possible to reproduce the results obtained for Wikipedia editing dynamics for a collection of single pages as well as the averaged results. Using a stochastic process framework, a recursive equation was obtained for the average of the number of edits per editor that seems to describe the editing behavior in Wikipedia.

  19. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference & APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    Science.gov (United States)

    2016-02-01

    The iMEC 2015 is the second International Manufacturing Engineering Conference organized by the Faculty of Manufacturing, Universiti Malaysia Pahang (UMP), held from 12-14th November 2015 in Kuala Lumpur, Malaysia, with a theme "Materials, Manufacturing and Systems for Tomorrow". For the first time, iMEC is organized together with 3rd Asia- Pacific Conference on Manufacturing System (APCOMS 2015) which owned by Fakulti Teknologi Industri, Institut Teknologi Bandung (ITB), Indonesia. This is an extended collaboration between UMP and ITB to intensify knowledge sharing and experiences between higher learning institutions. This conference (iMEC & APCOMS 2015) is a platform for knowledge exchange and the growth of ideas, particularly in manufacturing engineering. The conference aims to bring researchers, academics, scientists, students, engineers and practitioners from around the world together to present their latest findings, ideas, developments and applications related to manufacturing engineering and other related research areas. With rapid advancements in manufacturing engineering, iMEC is an appropriate medium for the associated community to keep pace with the changes. In 2015, the conference theme is “Materials, Manufacturing and Systems for Tomorrow” which reflects the acceleration of knowledge and technology in global manufacturing. The papers in these proceedings are examples of the work presented at the conference. They represent the tip of the iceberg, as the conference attracted over 200 abstracts from Malaysia, Indonesia, Japan, United Kingdom, Australia, India, Bangladesh, South Africa, Turkey and Morocco and 151 full papers were accepted in these proceedings. The conference was run in four parallel sessions with 160 presenters sharing their latest finding in the areas of manufacturing process, systems, advanced materials and automation. The first keynote presentation was given by Prof. B. S. Murthy (IIT, Madras) on "Nanomaterials with Exceptional

  20. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference and APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    International Nuclear Information System (INIS)

    2016-01-01

    The iMEC 2015 is the second International Manufacturing Engineering Conference organized by the Faculty of Manufacturing, Universiti Malaysia Pahang (UMP), held from 12-14th November 2015 in Kuala Lumpur, Malaysia, with a theme 'Materials, Manufacturing and Systems for Tomorrow'. For the first time, iMEC is organized together with 3rd Asia- Pacific Conference on Manufacturing System (APCOMS 2015) which owned by Fakulti Teknologi Industri, Institut Teknologi Bandung (ITB), Indonesia. This is an extended collaboration between UMP and ITB to intensify knowledge sharing and experiences between higher learning institutions. This conference (iMEC and APCOMS 2015) is a platform for knowledge exchange and the growth of ideas, particularly in manufacturing engineering. The conference aims to bring researchers, academics, scientists, students, engineers and practitioners from around the world together to present their latest findings, ideas, developments and applications related to manufacturing engineering and other related research areas. With rapid advancements in manufacturing engineering, iMEC is an appropriate medium for the associated community to keep pace with the changes. In 2015, the conference theme is “Materials, Manufacturing and Systems for Tomorrow” which reflects the acceleration of knowledge and technology in global manufacturing. The papers in these proceedings are examples of the work presented at the conference. They represent the tip of the iceberg, as the conference attracted over 200 abstracts from Malaysia, Indonesia, Japan, United Kingdom, Australia, India, Bangladesh, South Africa, Turkey and Morocco and 151 full papers were accepted in these proceedings. The conference was run in four parallel sessions with 160 presenters sharing their latest finding in the areas of manufacturing process, systems, advanced materials and automation. The first keynote presentation was given by Prof. B. S. Murthy (IIT, Madras) on &apos

  1. Coronary CT angiography in obese patients using 3rd generation dual-source CT: effect of body mass index on image quality

    International Nuclear Information System (INIS)

    Mangold, Stefanie; Wichmann, Julian L.; Schoepf, U.J.; Litwin, Sheldon E.; Canstein, Christian; Varga-Szemes, Akos; Fuller, Stephen R.; Stubenrauch, Andrew C.; De Cecco, Carlo N.; Muscogiuri, Giuseppe; Nikolaou, Konstantin

    2016-01-01

    To evaluate the image quality of coronary CT angiography (CCTA) in obese patients using a 3 rd generation, dual-source CT scanner. We retrospectively evaluated 102 overweight and obese patients who had undergone CCTA. Studies were performed with 3 rd generation dual-source CT, prospectively ECG-triggered acquisition at 120 kV, and automated tube current modulation. Advanced modeled iterative reconstruction was used. Patients were divided into three BMI groups: (1) 25-29.9 kg/m 2 ; (2) 30-39.9 kg/m 2 ; (3) ≥ 40 kg/m 2 . Vascular attenuation in the coronary arteries was measured. Contrast-to-noise ratio (CNR) was calculated. Image quality was subjectively evaluated using five-point scales. Image quality was considered diagnostic in 97.6 % of examinations. CNR was consistently adequate in all groups but decreased for groups 2 and 3 in comparison to group 1 as well as for group 3 compared to group 2 (p = 0.001, respectively). Subjective image quality was significantly higher in group 1 compared to group 3 (attenuation proximal: 4.8 ± 0.4 vs. 4.4 ± 0.6, p = 0.011; attenuation distal: 4.5 ± 0.7 vs. 4.0 ± 0.8, p = 0.019; noise: 4.7 ± 0.6 vs. 3.8 ± 0.7, p < 0.001). The mean effective dose was 9.5 ± 3.9 mSv for group 1, 11.4 ± 4.7 mSv for group 2 and 14.0 ± 6.4 mSv for group 3. Diagnostic image quality can be routinely obtained at CCTA in obese patients with 3 rd generation DSCT at 120 kV. (orig.)

  2. [Effect of Erlotinib in 2nd and 3rd Line Anticancer Treatment in Patients with Squamous Cell Lung Cancer - Case Series].

    Science.gov (United States)

    Šatánková, M; Brat, K; Tomíšková, M; Robešová, B; Skřičková, J

    Squamous cell carcinoma of the lung (SCC) represents cca 30-40% of new cases of non-small cell lung cancer (NSCLC) in the Czech Republic. The tyrosine kinase inhibitor erlotinib is indicated as a 1st line treatment for patients with locally advanced and metastatic disease and activating mutations in endothelial growth factor receptor (EGFR), or as a 2nd or 3rd line treatment in EGFR-negative NSCLC patients after chemotherapeutic failure. We present three case reports of patients with SCC treated with erlotinib as a 2nd or 3rd line of treatment. All patients were verified by histological analysis of tumor samples. EGFR mutation status was negative in one patient, while the other samples were not suitable for genetic screening. The therapeutic response to erlotinib lasted for 68, 40, and 13 months, resp. The patient with the longest therapeutic response (patient no. 1) is still continuing erlotinib treatment (as of December 2016). The overall survival of the two patients who died was 50 and 43 months, resp. One patient died of an unknown cause with no signs of progression of the disease on CT scans. The other patient died of terminal progression of the oncological disease. All three patients experienced major therapeutic benefit from erlotinib treatment as shown by the long periods of progression-free survival and prolonged overall survival. The three case reports demonstrate that erlotinib may be effective as a 2nd or 3rd line treatment in patients with SCC, especially in patients with limited alternative anticancer treatment options.Key words: non-small cell lung cancer - squamous cell carcinoma - erlotinib - treatment - tyrosine kinase inhibitor The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 5. 8. 2016Accepted: 14. 12. 2016.

  3. Irradiation experiments of 3rd, 4th and 5th fuel assemblies by an in-pile gas loop, OGL-1

    International Nuclear Information System (INIS)

    Fukuda, Kousaku; Kobayashi, Fumiaki; Hayashi, Kimio; Minato, Kazuo; Kikuchi, Teruo; Adachi, Mamoru; Iwamoto, Kazumi; Ikawa, Katsuichi; Itami, Hiroharu.

    1986-07-01

    Three irradiation experiments for 3rd, 4th and 5th fuel assemblies which had been composed of VHTR reference coated particle fuels and graphite components were carried out by an in-pile gas loop, OGL-1 during 1979 and 1982. The main purposes of these experiments were to study on bowing of the fuel rod by irradiation for the 3rd fuel assembly, to study on fuel behavior under relatively low burnup irradiation for the 4th fuel assembly, and to study on fuel behavior up to full burnup of VHTR design for the 5th fuel assembly. For understanding in-pile fuel behavior, fractional releases of fission gases from each fuel assembly were estimated by measuring the fission gas concentrations in the primary loop of OGL-1. The post-irradiation examination (PIE) was carried out extensively on the fuel block, the fuel rods and the fuel compacts in Tokai Hot Laboratory. Also, made were the measurements of metallic fission product distributions in the fuel assemblies and the fuel rods. The results in these experiments were given as follows ; bowing of the fuel rod in the 3rd fuel assembly was 0.7 mm, but integrity of the rod was kept under irradiation. Fractional release of the fission gas from the 4th fuel assembly remained in the order of 10 -7 during irradiation, suggesting that the fuel performance was excellent. The fractional release from the 5th fuel assembly, on the other hand, was in the order of 10 -5 which was the same level in the VHTR design. (author)

  4. Coronary CT angiography in obese patients using 3(rd) generation dual-source CT: effect of body mass index on image quality.

    Science.gov (United States)

    Mangold, Stefanie; Wichmann, Julian L; Schoepf, U Joseph; Litwin, Sheldon E; Canstein, Christian; Varga-Szemes, Akos; Muscogiuri, Giuseppe; Fuller, Stephen R; Stubenrauch, Andrew C; Nikolaou, Konstantin; De Cecco, Carlo N

    2016-09-01

    To evaluate the image quality of coronary CT angiography (CCTA) in obese patients using a 3(rd) generation, dual-source CT scanner. We retrospectively evaluated 102 overweight and obese patients who had undergone CCTA. Studies were performed with 3(rd) generation dual-source CT, prospectively ECG-triggered acquisition at 120 kV, and automated tube current modulation. Advanced modeled iterative reconstruction was used. Patients were divided into three BMI groups: 1)25-29.9 kg/m(2); 2)30-39.9 kg/m(2); 3) ≥ 40 kg/m(2). Vascular attenuation in the coronary arteries was measured. Contrast-to-noise ratio (CNR) was calculated. Image quality was subjectively evaluated using five-point scales. Image quality was considered diagnostic in 97.6 % of examinations. CNR was consistently adequate in all groups but decreased for groups 2 and 3 in comparison to group 1 as well as for group 3 compared to group 2 (p = 0.001, respectively). Subjective image quality was significantly higher in group 1 compared to group 3 (attenuation proximal: 4.8 ± 0.4 vs. 4.4 ± 0.6, p = 0.011; attenuation distal: 4.5 ± 0.7 vs. 4.0 ± 0.8, p = 0.019; noise: 4.7 ± 0.6 vs. 3.8 ± 0.7, p quality can be routinely obtained at CCTA in obese patients with 3(rd) generation DSCT at 120 kV. • Diagnostic CCTA can be routinely performed in obese patients with 3 (rd) generation DSCT. • 120-kV tube voltage allows diagnostic image quality in patients with BMI > 40 kg/m (2) . • 80-ml contrast medium can be administered without significant decline in vascular attenuation.

  5. Passive magnetic bearing in the 3rd generation miniature axial flow pump-the valvo pump 2.

    Science.gov (United States)

    Okamoto, Eiji; Ishida, Yuya; Yano, Tetsuya; Mitamura, Yoshinori

    2015-06-01

    The new miniature axial flow pump (valvo pump 2) that is installed at the base of the ascending aorta consists of a six-phase stator, an impeller in which four neodymium magnets are incorporated, and passive magnetic bearings that suspend the impeller for axial levitation. The impeller is sustained by hydrodynamic force between the blade tip of the impeller and the inner housing of the stator. The passive magnetic bearing consists of a ring neodymium magnet and a columnar neodymium magnet. The ring neodymium magnet is set in the stationary side and the columnar neodymium magnet is incorporated in the impeller shaft. Both neodymium magnets are coaxially mounted, and the anterior and posterior passive magnetic bearings suspend the impeller by repulsion force against the hydrodynamic force that acts to move the impeller in the inflow port direction. The passive magnetic bearing was evaluated by a tensile test, and the levitation force of 8.5 N and stiffness of 2.45 N/mm was obtained. Performance of the axial flow pump was evaluated by an in vitro experiment. The passive magnetic bearing showed sufficient levitation capacity to suspend the impeller in an axial direction. In conclusion, the passive magnetic bearing is promising to be one of levitation technology for the third-generation axial flow blood pump.

  6. Report of the 3rd RCM on Improved High Current Liquid and Gas Targets for Cyclotron Produced Radioisotopes

    International Nuclear Information System (INIS)

    2009-01-01

    The overall objective of this CRP was the development of new accelerator targetry technology including several target systems but focusing on the reliable production of carbon-11 and fluorine-18 in various chemical forms with a view to increasing production yields, specific activity, improving the economics of production and the availability of the radiotracers. Significant advances have been made under this CRP in the development and standardization of high power gas and liquid targets. This CRP has resulted in the development of methods which can be used in high power targets to increase Carbon-11, Fluorine-18, Nitrogen-13, Iodine-123 and Krypton-81m, specific activities (a least a two fold increase), chemical purities as well as ensuring reliability of the production of the radiopharmaceuticals derived from these radionuclides. More importantly, these advances have minimized the unnecessarily operator exposure to radiation. In addition, knowledge of recovery and characterization of enriched H 2 18 O was also gained. Through this research the production capabilities with regard to [ 18 F]F - , [ 11 C]CO 2 and [ 11 C]CH 4 have increased 3 to 6 fold. A high current niobium target system has been designed, tested and put in service which could increase production capability of 18 FDG by a factor of 2.5. A survey of target maintenance procedures has been carried out and the results of this survey are reported in this CRP. It was determined that the tritium introduced by the inevitable nuclear reactions does not pose any health physics problems either during the tracer manufacturer or during potential water reclamation. It was further determined that radionuclides produced in the metal foil during irradiation are found in the target water at very low concentrations. These impurities can be essentially eliminated by using noble metal plated foils. The radionuclides can also be reduced by the separation technology typically used for fluorine extraction from the O-18

  7. With this Special Edition

    Directory of Open Access Journals (Sweden)

    Oscar Antonio Martínez Molina

    2017-02-01

    Full Text Available With this Special Edition, the refereed Scientific Magazine, published in February 2017, presents a nourished and multidisciplinary theme, from the relationship of Environmental Education, in this ecological sharing man-environment; the social responsibility from the Management environment and the motivational values ​​conducive to the teaching performance in the different educational levels. Twenty-five (25 articles, generated from research production in university environments at the International level, are a signature of the quality of articles / essays presented in this Special Edition. Several reasons motivate the literary pen of our authors, adjusting to the rhythm of the times and the use of new technologies; and in correspondence with the care of the environment, this way of disseminating and making visible the scientific contents of humanistic and social court, support the care and protection of the forests, being an online production, in the Cloud. Thanks to the support of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo INDTEC, CA, Scientific Magazine has been able to develop from the cooperative work of the people who compose its different committees: Editorial Academic Committee, Academic Scientific Committee and the Arbitrators in the review and valuation of the quality of the articles. With these assets, the Scientific Magazine, opening to the general public and especially to the academic new intellectual horizons.

  8. Modern Newspaper Editing. Second Edition.

    Science.gov (United States)

    Gilmore, Gene; Root, Robert

    This volume explains recent technological changes in newspaper publication, comments on how the copy editor must adjust to facilitate these changes, and provides a discussion of some of the ethical and moral questions which every editor must face in appraising the news, in deciding what to print and what to feature, and in displaying material. The…

  9. Twenty years of operation of the Radioisotope Department of the 3rd Medical Clinic, Faculty of General Medicine, Charles University in Prague

    International Nuclear Information System (INIS)

    Kapitola, J.

    1983-01-01

    Twenty years ago a radioisotope department was established in the old building of the 3rd Medical Clinic in Prague 2. The department is suitably placed and meets present requirements. It was set up as part of the 3rd Medical Clinic and of the Laboratory for endocrinology and Metabolism which gave it its main orientation and scope. Its present scope is much broader. In the twenty years since it was established 115,800 examinations were carried out, some 40 examination methods were introduced, 103 publications published, members of the department were co-authors of another 113 publications, they completed 11 research projects. The production of the department represents a substantial part of laboratory material especially in the diagnosis of endocrinopathy and metabolic disorders at the Clinic and is a significant part of the material of a number of research projects. The department has significantly contributed to the development of nuclear medicine in the Czechoslovak Socialist Republic in thyroid diagnosis, by the first introduction of radioimmunoassay methods, by the introduction of certain other special examination and laboratory methods and is currently taking part in the fulfilment of tasks given by the zoning of nuclear medicine in health care in Czechoslovakia in general and in Prague in particular. (author)

  10. Genome editing systems in novel therapies.

    Science.gov (United States)

    Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui

    2016-01-01

    Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in human cells, however, had prevented its clinical application until the recent advancements in designer endonuclease technologies. The significantly improved genome editing efficiencies aided by ZFN, TALEN, and CRISPR systems provide unprecedented opportunities not only for biomedical research, but also for developing novel therapies. Applications based on these genome editing tools to disrupt deleterious genes, correct genetic mutations, deliver functional transgenes more effectively or even modify the epigenetic landscape are being actively investigated for gene and cell therapy purposes. Encouraging results have been obtained in limited clinical trials in the past two years. While most of the applications are still in proof-of-principle or preclinical development stages, it is anticipated that the coming years will see increasing clinical success in novel therapies based on the modern genome editing technologies. It should be noted that critical issues still remain before the technologies can be translated into more reliable therapies. These key issues include off-target evaluation, establishing appropriate preclinical models and improving the currently low efficiency of homology-based precise gene replacement. In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation.

  11. A genome editing primer for the hematologist

    Science.gov (United States)

    Hoban, Megan D.

    2016-01-01

    Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand nicks and targeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments. In this review, we examine the various technologies, describe their advantages and shortcomings for engendering useful genetic alterations, and consider future prospects for genome editing to impact hematology. PMID:27053532

  12. Introductory physics of nuclear medicine. Third edition

    International Nuclear Information System (INIS)

    Chandra, R.

    1987-01-01

    The new third edition includes essential details and many examples and problems taken from the routine practice of nuclear medicine. Basic principles and underlying concepts are explained, although it is assumed that the reader has some current use as a bone densitometer. For resident physicians in nuclear medicine, residents in pathology, radiology, and internal medicine, and students of nuclear medicine technology, the third edition offers a simplified and reliable approach to the physics and basic sciences of nuclear medicine

  13. A genome editing primer for the hematologist

    OpenAIRE

    Hoban, Megan D.; Bauer, Daniel E.

    2016-01-01

    Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand ...

  14. Proceedings of the International Conference on Algebraic Methodology and Software Technology (3rd) Held in The Netherlands on June 21 - 25, 1993

    Science.gov (United States)

    1993-06-25

    Larousain e, S. Pinchinat, Ph. Schnoebelen (LIFIA-IMAG Grenoble): 0 Translation riesults for modal logic. of reactioe .gytems 15:40-16:10 LN. Kaufman...Springer, July 1993. - w W"- W 0 - 7 Translation Results for Modal Logics of Reactive Systems * F. Laroussinie, S. Pinchinat tand Ph. Schnoebelen " LIFIA...is pure-peat if it does vot conain~ future-time operater, andis #aspaite (in Geabp’s sesee) if it is &boolemancom- f= (V (A (fki,]k.3 A A ((ki))ip

  15. Assisted reproductive technologies in Portuguese law--commentary to the Judgment no. 101/2009, of March the 3rd of the Portuguese Constitutional Court.

    Science.gov (United States)

    Raposo, Vera Lúcia; Vale e Reis, Rafael

    2009-01-01

    Recently the Portuguese Constitutional Court was asked to analyze the constitutionality of the law on assisted reproduction, Law nr 32/2006. The request was presented by a conservative group, arguing, basically, that the law disregarded the juridical protection due to the embryo and to the participants in reproductive techniques. The main critics pointed out were related with the legitimacy of using reproductive techniques, the absence of a maximum age for beneficiaries, the authorization of embryo experimentation, the decision of not criminalizing every contract of surrogate motherhood, among some other critics. However, the Court concluded that none of the pointed norms went against Constitutional rules and principles.

  16. 3rd International Algebra Conference

    CERN Document Server

    Fong, Yuen; Zelmanov, Efim

    2003-01-01

    This volume contains one invited lecture which was presented by the 1994 Fields Medal­ ist Professor E. Zelmanov and twelve other papers which were presented at the Third International Conference on Algebra and Their Related Topics at Chang Jung Christian University, Tainan, Republic of China, during the period June 26-July 1, 200l. All papers in this volume have been refereed by an international referee board and we would like to express our deepest thanks to all the referees who were so helpful and punctual in submitting their reports. Thanks are also due to the Promotion and Research Center of National Science Council of Republic of China and the Chang Jung Christian University for their generous financial support of this conference. The spirit of this conference is a continuation of the last two International Tainan­ Moscow Algebra Workshop on Algebras and Their Related Topics which were held in the mid-90's of the last century. The purpose of this very conference was to give a clear picture of the rece...

  17. 3rd International EXAFS Conference

    CERN Document Server

    Hedman, Britt; Penner-Hahn, James

    1984-01-01

    This volume contains the Proceedings of the Third International EXAFS Conference, hosted by Stanford University and the Stanford Synchrotron Radiation Laboratory on July 16-20, 1984. The meeting, co-chaired by Professors Arthur Bienenstock and Keith Hodgson, was attended by over 200 scientists representing a wide range of scientific disciplines. The format of the meeting consisted of 51 invited presenta­ tions and four days of poster sessions. This Proceedings is a compilation of 139 contributions from both invited speakers and authors of contributed posters. The last ten years has seen the rapid maturation of x-ray absorption spectrosco­ pyas a scientific discipline. The vitality of the field is reflected in the diver­ sity of applications found in the Proceedings. Recent work continues to probe the limits of x-ray spectroscopy, with proven techniques being extended to, for examp­ le, very low or high energy studies, to very dilute systems, and to studies of surface structure. In fact, the title of the c...

  18. X-ray holographic microscopy with zone plates applied to biological samples in the water window using 3rd harmonic radiation from the free-electron laser FLASH.

    Science.gov (United States)

    Gorniak, T; Heine, R; Mancuso, A P; Staier, F; Christophis, C; Pettitt, M E; Sakdinawat, A; Treusch, R; Guerassimova, N; Feldhaus, J; Gutt, C; Grübel, G; Eisebitt, S; Beyer, A; Gölzhäuser, A; Weckert, E; Grunze, M; Vartanyants, I A; Rosenhahn, A

    2011-06-06

    The imaging of hydrated biological samples - especially in the energy window of 284-540 eV, where water does not obscure the signal of soft organic matter and biologically relevant elements - is of tremendous interest for life sciences. Free-electron lasers can provide highly intense and coherent pulses, which allow single pulse imaging to overcome resolution limits set by radiation damage. One current challenge is to match both the desired energy and the intensity of the light source. We present the first images of dehydrated biological material acquired with 3rd harmonic radiation from FLASH by digital in-line zone plate holography as one step towards the vision of imaging hydrated biological material with photons in the water window. We also demonstrate the first application of ultrathin molecular sheets as suitable substrates for future free-electron laser experiments with biological samples in the form of a rat fibroblast cell and marine biofouling bacteria Cobetia marina.

  19. Final report for the 3rd Ex-Vessel Neutron Dosimetry Installations and Evaluations for Kori Unit 1 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai (and others)

    2008-03-15

    This report describes a neutron fluence assessment performed for the Kori Unit 1 pressure vessel belt line region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the belt line region of the pressure vessel. After Cycle 23 of reactor operation, 3rd Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 1 to provide continuous monitoring of the belt line region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 24.

  20. An estimate of the minting method of three silver coins of the 3rd century B.C. through their microstructural study

    International Nuclear Information System (INIS)

    Pistofidis, N.; Vourlias, G.; Dilo, T.; Civici, N.; Gjongecaj, Sh.; Skolianos, S.; Polychroniadis, E.K.

    2010-01-01

    The microstructure of three silver coins of the 3rd century B.C. from the Illyrian King Monounios and the ancient Greek cities of Dyrrachion and Corcyra, belonging to the Kreshpan hoard, was determined with X-ray diffraction and transmission electron microscopy in order to investigate their minting method. It is deduced that the coins are characterized by a large number of structural defects, mainly dislocations, twins and microtwins, which in some cases were bent. These crystal defects are common in each of the coins examined. This information allowed the formulation of a possible minting method. Since twins in FCC metals are formed with thermal treatment, and mechanical twinning is rather improbable, it seems that the coins were initially hot-worked. Bent twins indicate that working continued during cooling. Especially for the Corcyra coin it was deduced that it was treated at higher temperature or its cooling rate was lower.

  1. Sarmatian Attributes in Archaeological Complexes of Catacombs Burials in Arys Culture of Southern Kazakhstan (1st Century B.C. - 3rd Century A.D.

    Directory of Open Access Journals (Sweden)

    Podushkin Aleksandr Nikolaevich

    2015-12-01

    Full Text Available The publication is devoted to archaeological research of monuments of the catacomb of Arys culture of Southern Kazakhstan (1st Century B.C. - 3rd Century A.D.. Now scientists have a complete understanding of the range and typology, periodization and chronology of monuments of this culture. There are three stages: Karaultobe (4th century B.C. - 1st century A.D.; Karatobe (1st Century B.C. - 4th century A.D.; Altintobe (4th-6th centuries A.D.. These stages are characterized by specific clusters of signs in the form of artifacts. The author also carried out the ethnic attribution of the Arys culture in association with the ancient state Kangiuj. As a result of this work, the ethnicity of the state Kangiuj was revealed: in particular, late Saka’s, Sarmatian, Huns and Kangiuj ethnic components which are relevant to archaeological complexes, were identified. In the Arys monuments of culture the author discovered complexes of findings which associated with the Sarmatian world of Eurasia by their ethno-cultural parameters. They include typical for the Sarmatians list of ritual action and the funerary equipment, including weapons, bronze mirrors, ritual and religious objects, signs-tamgas, jewelry (including Egyptian faience, articles in “animal”, gold-turquoise and polychrome style. The characteristics of the burial complexes of catacombs of the Arys culture discussed in the publication and corresponding to chronological calculations and ethno-cultural interpretations, allow to speak about presence in the territory of South Kazakhstan of the Asian Sarmatians or any local branch of the Union of the Sarmatian tribes in the 1st century B.C. - 3rd century A.D.

  2. Limbic system development underlies the emergence of classical fear conditioning during the 3rd and 4th weeks of life in the rat

    Science.gov (United States)

    Deal, Alex L.; Erickson, Kristen J.; Shiers, Stephanie I.; Burman, Michael A.

    2016-01-01

    Classical fear conditioning creates an association between an aversive stimulus and a neutral stimulus. Although the requisite neural circuitry is well understood in mature organisms, the development of these circuits is less well studied. The current experiments examine the ontogeny of fear conditioning and relate it to neuronal activation assessed through immediate early gene (IEG) expression in the amygdala, hippocampus, perirhinal cortex, and hypothalamus of periweanling rats. Rat pups were fear conditioned, or not, during the 3rd or 4th weeks of life. Neuronal activation was assessed by quantifying expression of FBJ osteosarcoma oncogene (FOS) using immunohistochemistry (IHC) in Experiment 1. Fos and early growth response gene-1 (EGR1) expression was assessed using qRT-PCR in Experiment 2. Behavioral data confirm that both auditory and contextual fear continue to emerge between PD 17 and 24. The IEG expression data are highly consistent with these behavioral results. IHC results demonstrate significantly more FOS protein expression in the basal amygdala of fear conditioned PD 23 subjects compared to control subjects, but no significant difference at PD 17. qRT-PCR results suggest specific activation of the amygdala only in older subjects during auditory fear expression. A similar effect of age and conditioning status was also observed in the perirhinal cortex during both contextual and auditory fear expression. Overall, the development of fear conditioning occurring between the 3rd and 4th weeks of life appears to be at least partly attributable to changes in activation of the amygdala and perirhinal cortex during fear conditioning or expression. PMID:26820587

  3. 4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

  4. A Prospective Treatment Option for Lysosomal Storage Diseases: CRISPR/Cas9 Gene Editing Technology for Mutation Correction in Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Chloe L. Christensen

    2017-02-01

    Full Text Available Ease of design, relatively low cost and a multitude of gene-altering capabilities have all led to the adoption of the sophisticated and yet simple gene editing system: clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9. The CRISPR/Cas9 system holds promise for the correction of deleterious mutations by taking advantage of the homology directed repair pathway and by supplying a correction template to the affected patient’s cells. Currently, this technique is being applied in vitro in human-induced pluripotent stem cells (iPSCs to correct a variety of severe genetic diseases, but has not as of yet been used in iPSCs derived from patients affected with a lysosomal storage disease (LSD. If adopted into clinical practice, corrected iPSCs derived from cells that originate from the patient themselves could be used for therapeutic amelioration of LSD symptoms without the risks associated with allogeneic stem cell transplantation. CRISPR/Cas9 editing in a patient’s cells would overcome the costly, lifelong process associated with currently available treatment methods, including enzyme replacement and substrate reduction therapies. In this review, the overall utility of the CRISPR/Cas9 gene editing technique for treatment of genetic diseases, the potential for the treatment of LSDs and methods currently employed to increase the efficiency of this re-engineered biological system will be discussed.

  5. Genome edited animals: Learning from GM crops?

    Science.gov (United States)

    Bruce, Ann

    2017-06-01

    Genome editing of livestock is poised to become commercial reality, yet questions remain as to appropriate regulation, potential impact on the industry sector and public acceptability of products. This paper looks at how genome editing of livestock has attempted to learn some of the lessons from commercialisation of GM crops, and takes a systemic approach to explore some of the complexity and ambiguity in incorporating genome edited animals in a food production system. Current applications of genome editing are considered, viewed from the perspective of past technological applications. The question of what is genome editing, and can it be considered natural is examined. The implications of regulation on development of different sectors of livestock production systems are studied, with a particular focus on the veterinary sector. From an EU perspective, regulation of genome edited animals, although not necessarily the same as for GM crops, is advocated from a number of different perspectives. This paper aims to open up new avenues of research on genome edited animals, extending from the current primary focus on science and regulation, to engage with a wider-range of food system actors.

  6. Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE

    NARCIS (Netherlands)

    de Wert, Guido; Heindryckx, Björn; Pennings, Guido; Clarke, Angus; Eichenlaub-Ritter, Ursula; van El, Carla G.; Forzano, Francesca; Goddijn, Mariëtte; Howard, Heidi C.; Radojkovic, Dragica; Rial-Sebbag, Emmanuelle; Dondorp, Wybo; Tarlatzis, Basil C.; Cornel, Martina C.

    2018-01-01

    Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together developed a Background document and

  7. Genome editing with engineered nucleases in plants.

    Science.gov (United States)

    Osakabe, Yuriko; Osakabe, Keishi

    2015-03-01

    Numerous examples of successful 'genome editing' now exist. Genome editing uses engineered nucleases as powerful tools to target specific DNA sequences to edit genes precisely in the genomes of both model and crop plants, as well as a variety of other organisms. The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as genome editing tools, in the form of designed ZF nucleases (ZFNs). More recently, transcription activator-like effector nucleases (TALENs), as well as the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, which utilizes RNA-DNA interactions, have proved useful. A key step in genome editing is the generation of a double-stranded DNA break that is specific to the target gene. This is achieved by custom-designed endonucleases, which enable site-directed mutagenesis via a non-homologous end-joining (NHEJ) repair pathway and/or gene targeting via homologous recombination (HR) to occur efficiently at specific sites in the genome. This review provides an overview of recent advances in genome editing technologies in plants, and discusses how these can provide insights into current plant molecular biology research and molecular breeding technology. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  8. Fuel Cell Handbook, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  9. Ethical and regulatory aspects of genome editing.

    Science.gov (United States)

    Kohn, Donald B; Porteus, Matthew H; Scharenberg, Andrew M

    2016-05-26

    Gene editing is a rapidly developing area of biotechnology in which the nucleotide sequence of the genome of living cells is precisely changed. The use of genome-editing technologies to modify various types of blood cells, including hematopoietic stem cells, has emerged as an important field of therapeutic development for hematopoietic disease. Although these technologies offer the potential for generation of transformative therapies for patients suffering from myriad disorders of hematopoiesis, their application for therapeutic modification of primary human cells is still in its infancy. Consequently, development of ethical and regulatory frameworks that ensure their safe and effective use is an increasingly important consideration. Here, we review a number of issues that have the potential to impact the clinical implementation of genome-editing technologies, and suggest paths forward for resolving them such that new therapies can be safely and rapidly translated to the clinic. © 2016 by The American Society of Hematology.

  10. A Kinesthetic Learning Approach to Earth Science for 3rd and 4th Grade Students on the Pajarito Plateau, Los Alamos, NM

    Science.gov (United States)

    Wershow, H. N.; Green, M.; Stocker, A.; Staires, D.

    2010-12-01

    Current efforts towards Earth Science literacy in New Mexico are guided by the New Mexico Science Benchmarks [1]. We are geoscience professionals in Los Alamos, NM who believe there is an important role for non-traditional educators utilizing innovative teaching methods. We propose to further Earth Science literacy for local 3rd and 4th grade students using a kinesthetic learning approach, with the goal of fostering an interactive relationship between the students and their geologic environment. We will be working in partnership with the Pajarito Environmental Education Center (PEEC), which teaches the natural heritage of the Pajarito Plateau to 3rd and 4th grade students from the surrounding area, as well as the Family YMCA’s Adventure Programs Director. The Pajarito Plateau provides a remarkable geologic classroom because minimal structural features complicate the stratigraphy and dramatic volcanic and erosional processes are plainly on display and easily accessible. Our methodology consists of two approaches. First, we will build an interpretive display of the local geology at PEEC that will highlight prominent rock formations and geologic processes seen on a daily basis. It will include a simplified stratigraphic section with field specimens and a map linked to each specimen’s location to encourage further exploration. Second, we will develop and implement a kinesthetic curriculum for an exploratory field class. Active engagement with geologic phenomena will take place in many forms, such as a scavenger hunt for precipitated crystals in the vesicles of basalt flows and a search for progressively smaller rhyodacite clasts scattered along an actively eroding canyon. We believe students will be more receptive to origin explanations when they possess a piece of the story. Students will be provided with field books to make drawings of geologic features. This will encourage independent assessment of phenomena and introduce the skill of scientific observation. We

  11. The Safety of Artemisinin Derivatives for the Treatment of Malaria in the 2nd or 3rd Trimester of Pregnancy: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Stephanie D Kovacs

    Full Text Available Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy. However, several organ systems are still under development later in pregnancy. We conducted a systematic review and meta-analysis of the occurrence of adverse pregnancy outcomes among women treated with artemisinins monotherapy or as artemisinin-based combination therapy during the 2nd or 3rd trimesters relative to pregnant women who received non-artemisinin antimalarials or none at all. Pooled odds ratio (POR were calculated using Mantel-Haenszel fixed effects model with a 0.5 continuity correction for zero events. Eligible studies were identified through Medline, Embase, and the Malaria in Pregnancy Consortium Library. Twenty studies (11 cohort studies and 9 randomized controlled trials contributed to the analysis, with 3,707 women receiving an artemisinin, 1,951 a non-artemisinin antimalarial, and 13,714 no antimalarial. The PORs (95% confidence interval (CI for stillbirth, fetal loss, and congenital anomalies when comparing artemisinin versus quinine were 0.49 (95% CI 0.24-0.97, I2 = 0%, 3 studies; 0.58 (95% CI 0.31-1.16, I2 = 0%, 6 studies; and 1.00 (95% CI 0.27-3.75, I2 = 0%, 3 studies, respectively. The PORs comparing artemisinin users to pregnant women who received no antimalarial were 1.13 (95% CI 0.77-1.66, I2 = 86.7%, 3 studies; 1.10 (95% CI 0.79-1.54, I2 = 0%, 4 studies; and 0.79 (95% CI 0.37-1.67, I2 = 0%, 3 studies for miscarriage, stillbirth and congenital anomalies respectively. Treatment with artemisinin in 2nd and 3rd trimester was not associated with increased risks of congenital malformations or miscarriage and may be was associated with a reduced risk of stillbirths compared to quinine. This study updates the reviews

  12. Current and future editing reagent delivery systems for plant genome editing.

    Science.gov (United States)

    Ran, Yidong; Liang, Zhen; Gao, Caixia

    2017-05-01

    Many genome editing tools have been developed and new ones are anticipated; some have been extensively applied in plant genetics, biotechnology and breeding, especially the CRISPR/Cas9 system. These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems. Finally, we will reflect on possible future directions.

  13. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...

  14. Designed nucleases for targeted genome editing.

    Science.gov (United States)

    Lee, Junwon; Chung, Jae-Hee; Kim, Ho Min; Kim, Dong-Wook; Kim, Hyongbum

    2016-02-01

    Targeted genome-editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine and biotechnology. Using this genome-modifying technology, researchers can precisely and efficiently insert, remove or change specific sequences in various cultured cells, micro-organisms, animals and plants. This genome editing is based on the generation of double-strand breaks (DSBs), repair of which modifies the genome through nonhomologous end-joining (NHEJ) or homology-directed repair (HDR). In addition, designed nickase-induced generation of single-strand breaks can also lead to precise genome editing through HDR, albeit at relatively lower efficiencies than that induced by nucleases. Three kinds of designed nucleases have been used for targeted DSB formation: zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system. A growing number of researchers are using genome-editing technologies, which have become more accessible and affordable since the discovery and adaptation of CRISPR-Cas9. Here, the repair mechanism and outcomes of DSBs are reviewed and the three types of designed nucleases are discussed with the hope that such understanding will facilitate applications to genome editing. © 2015 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  15. Genome Editing for the Study of Cardiovascular Diseases.

    Science.gov (United States)

    Chadwick, Alexandra C; Musunuru, Kiran

    2017-03-01

    The opportunities afforded through the recent advent of genome-editing technologies have allowed investigators to more easily study a number of diseases. The advantages and limitations of the most prominent genome-editing technologies are described in this review, along with potential applications specifically focused on cardiovascular diseases. The recent genome-editing tools using programmable nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9), have rapidly been adapted to manipulate genes in a variety of cellular and animal models. A number of recent cardiovascular disease-related publications report cases in which specific mutations are introduced into disease models for functional characterization and for testing of therapeutic strategies. Recent advances in genome-editing technologies offer new approaches to understand and treat diseases. Here, we discuss genome editing strategies to easily characterize naturally occurring mutations and offer strategies with potential clinical relevance.

  16. The perceptions of professional soccer players on the risk of injury from competition and training on natural grass and 3rd generation artificial turf

    Science.gov (United States)

    2014-01-01

    Background The purpose of this study was to describe professional soccer players’ perceptions towards injuries, physical recovery and the effect of surface related factors on injury resulting from soccer participation on 3rd generation artificial turf (FT) compared to natural grass (NG). Methods Information was collected through a questionnaire that was completed by 99 professional soccer players from 6 teams competing in Major League Soccer (MLS) during the 2011 season. Results The majority (93% and 95%) of the players reported that playing surface type and quality influenced the risk of sustaining an injury. Players believed that playing and training on FT increased the risk of sustaining a non-contact injury as opposed to a contact injury. The players identified three surface related risk factors on FT, which they related to injuries and greater recovery times: 1) Greater surface stiffness 2) Greater surface friction 3) Larger metabolic cost to playing on artificial grounds. Overall, 94% of the players chose FT as the surface most likely to increase the risk of sustaining an injury. Conclusions Players believe that the risk of injury differs according to surface type, and that FT is associated with an increased risk of non-contact injury. Future studies should be designed prospectively to systematically track the perceptions of groups of professional players training and competing on FT and NG. PMID:24581229

  17. Seismic b-value anomalies prior to the 3rd January 2016, Mw = 6.7 Manipur earthquake of northeast India

    Science.gov (United States)

    Borgohain, Jayanta Madhab; Borah, Kajaljyoti; Biswas, Rajib; Bora, Dipok K.

    2018-04-01

    Spatial variation of seismic b-value is estimated in the Indo-Myanmar subduction zone of northeast (NE) India using the homogeneous part of earthquake catalogue (1996-2015), recorded by International Seismological Center (ISC), consisting of 895 events of magnitude MW ≥ 3.9. The study region is divided into 1° × 1° square grids and b-values are estimated at each grid by maximum likelihood method. In this study, the b-value varies from 0.75 to 1.54 in the region. Significant variation of low b-value in the respective location may indicate high stress accumulation in that region. Spatial variation reveals intermediate b-value anomalies around the epicenter of the Mw = 6.7 Manipur earthquake which occurred on 3rd January at 23:05 UTC (4 January 2016 at 04:35 IST). The variations of b-values are also estimated with respect to depth. The low b-value associated with the depth range ∼15-55 km, which may imply crustal homogeneity and high stress accumulation in the crust. Since, NE India lies in the seismic zone V of the country; this study can be helpful to understand seismotectonics in the region.

  18. In vitro effects of three woody plant and sainfoin extracts on 3rd-stage larvae and adult worms of three gastrointestinal nematodes.

    Science.gov (United States)

    Paolini, V; Fouraste, I; Hoste, H

    2004-07-01

    Most studies on the effects of tanniferous plants on nematodes have examined forages but have neglected the woody plants. Therefore, in vitro effects of extracts from 3 woody plants (Rubus fructicosus, Quercus robur, Corylus avellana) have been tested on trichostrongyles and compared to sainfoin, a legume forage. Because some in vivo results indicated that the effects of tannins differed depending on the parasitic species and/or stages, the effects were measured on 3rd-stage larvae (L3) and adult worms of Teladorsagia circumcincta, Haemonchlus contortus and Trichostrongylus colubriformis. The effects of plant extracts varied according to the plant sources, the parasite species and stages. For the woody plants, significant inhibitory effects were obtained on both stages of abomasal species. Results for T. colubriformis were more variable. Effects of sainfoin extracts were significant on T. colubriformis and H. contortus L3, and on abomasal adult worms. In order to assess the implications of tannins, polyethylene glycol (PEG), an inhibitor of tannins, was added to hazel tree, oak and sainfoin extracts. Without PEG, significant inhibitory effects on L3 and adult worms were confirmed. After addition of PEG, the larval migration and motility of adult worms were restored in most cases. These results confirm variations in effects depending on factors related to plants or parasites and suggest that tannins are partly responsible for the effects.

  19. The epiphyseal union of the medial clavicle determined by CT - an axillary method in age identification during adolescence and 3rd decade of life?

    International Nuclear Information System (INIS)

    Kreitner, K.F.; Schweden, F.; Schild, H.H.; Riepert, T.; Nafe, B.

    1997-01-01

    Purpose: To establish a reference population for the stages of epiphyseal union of the medical clavicle determined by CT. Material and methods: Retrospectively, the thoracic CTs of patients under 30 years of age were reevaluated. Basic conditions were the lack of a bone development disorder and a sufficient assessment of the medial clavicle in a bone window setting. The stages of epiphyseal union were categorized as follows: Stage 1 refers to nonunion without ossification of the epiphysis, Stage 2 to nonunion with a separate and ossified epiphysis, Stage 3 to partial, and Stage 4 to complete union. Results: Up to now, 279 individuals coul be included in the study. Stage 1 was observed till age 16, Stage 2 occurred from ages 13 through 22, Stage 3 was found from ages 16 through 26. Stage 4 was first noted at age 22, and in 100% of the sample at age 27. Conclusions: CT is well suitable to determine the stages of epiphyseal union of the medial clavicle. It may become a generally accepted method of age identification during adolescence and the 3rd decade of life. The presented data serve as a reference population at least for white Europeans. (orig.) [de

  20. Stable Isotope and Trace Element Studies on Gladiators and Contemporary Romans from Ephesus (Turkey, 2nd and 3rd Ct. AD) - Implications for Differences in Diet

    Science.gov (United States)

    Lösch, Sandra; Moghaddam, Negahnaz; Grossschmidt, Karl; Risser, Daniele U.; Kanz, Fabian

    2014-01-01

    The gladiator cemetery discovered in Ephesus (Turkey) in 1993 dates to the 2nd and 3rd century AD. The aim of this study is to reconstruct diverse diet, social stratification, and migration of the inhabitants of Roman Ephesus and the distinct group of gladiators. Stable carbon, nitrogen, and sulphur isotope analysis were applied, and inorganic bone elements (strontium, calcium) were determined. In total, 53 individuals, including 22 gladiators, were analysed. All individuals consumed C3 plants like wheat and barley as staple food. A few individuals show indication of consumption of C4 plants. The δ13C values of one female from the gladiator cemetery and one gladiator differ from all other individuals. Their δ34S values indicate that they probably migrated from another geographical region or consumed different foods. The δ15N values are relatively low in comparison to other sites from Roman times. A probable cause for the depletion of 15N in Ephesus could be the frequent consumption of legumes. The Sr/Ca-ratios of the gladiators were significantly higher than the values of the contemporary Roman inhabitants. Since the Sr/Ca-ratio reflects the main Ca-supplier in the diet, the elevated values of the gladiators might suggest a frequent use of a plant ash beverage, as mentioned in ancient texts. PMID:25333366

  1. Phonological awareness and general performance in reading: What’s the relation? A study with 2nd and 3rd year fundamental school students

    Directory of Open Access Journals (Sweden)

    Ana Paula Couceiro Figueira

    2017-01-01

    Full Text Available The objective of this study was to test the content and concurrent validity of Prolec-R (FIGUEIRA; LOPES, n.d., investigation version, exploring the relations as a proof of phonological awareness (phoneme synthesis, SICOLE-R evaluation (FIGUEIRA; LOBO; LOPES; JIMÉNEZ, n.d., investigation version. The theoretical background comprises the evaluation of cognitive processes involved in reading (JIMENEZ’S and CUETOS’S perspectives, in which the two tests employed assume too evaluate such processes, and are considered concurrent procedures. Both are destined to children from 6 to 12 years old. The methodology used, for exploration and accessibility, a sample containing children from the 2nd and 3rd year of elementary school, from the public and education systems in Coimbra and Beira Interior Norte. The results revealed the existence of a positive and significant relation between the reading of words, reading of pseudo words, grammatical structures, punctuation marks and sentence comprehension (PROLEC-R and the phoneme synthesis (SICOLE-R.

  2. [Regional asymmetries. What are the differences in lifestyles and life satisfaction among adolescents? A study of students of the 3rd cycle of basic education in Portugal].

    Science.gov (United States)

    Vieira, Tiago Paupério Ferreira; Alves, Nuno José Corte-Real Correia; Dias, Cláudia Salomé Lima; Da Fonseca, António Manuel Leal Ferreira Mendonça

    2015-01-01

    Based on the importance of behavior and life satisfaction for the health of young people and the considerable regional differences that exist in mainland Portugal, an investigation was conducted. It sought to verify differences in levels of the practice of sport, tobacco and alcohol consumption and life satisfaction among students of the 3rd cycle of basic education living in different inland/coastal and rural/urban areas. The sample consisted of 5624 adolescents, aged between 12 and 17 years. The instrument used for data collection was the "Inventory of Health-Related Behavior of Adolescents" and a translated version of "The Satisfaction With Life Scale". The results revealed that there are higher levels of smoking among young people living in urban and inland areas, higher levels of alcohol consumption among young people living in rural and inland areas and higher levels of life satisfaction among adolescents living in urban and coastal areas. Levels of sport were identical in all geographical areas. It was also found that there were significant differences in all variables of the analysis.

  3. Assembly of insect hormone enthusiasts at Nasu Highland, Japan: Report of the 3rd International Insect Hormone (21st Ecdysone) Workshop.

    Science.gov (United States)

    Niwa, Ryusuke; Nishimura, Takashi

    2018-01-01

    The 3rd International Insect Hormone (21st Ecdysone) Workshop (IIHW2017) was held in July 2017 at Nasu Highland, Japan. In the 40 years of the workshop's history, this was the first to be held in an Asian country. A total of 109 insect hormone researchers from 18 countries (62 overseas and 47 domestic participants) attended IIHW2017. During the workshop, all participants stayed on-site at the venue's hotel; this was ideal for fostering communication between participants, in particular, interactions between principal investigators and young scientists. The workshop featured one keynote, 64 oral, and 35 poster presentations spanning molecular biology, cell biology, developmental biology, neurobiology, chemical biology, physiology, and ecology of insect hormones, including ecdysteroids, juvenile hormones, and a variety of neuropeptides. The workshop provided an ideal platform for discussing insect hormone biology using not only the typical genetic model insect, the fruit fly Drosophila, but also a diversity of interesting insects, such as the silkworm, the red flour beetle, the cricket, the dragonfly, the social ant, the bloodsucking tick, and so on. The participants succeeded in sharing the latest knowledge in a wide range of insect hormone research fields and in joining active and constructive scientific discussions. © 2017 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

  4. The impact of male burials on the construction of Corded Ware identity: Reconstructing networks of information in the 3rd millennium BC.

    Directory of Open Access Journals (Sweden)

    Quentin Bourgeois

    Full Text Available The emergence of Corded Ware Groups throughout Europe in the 3rd millennium BC is one of the most defining events in European history. From the Wolga to the Rhine communities start to speak Indo-European languages and bury their dead in an extremely similar fashion. Recent ancient DNA-analyses identify a massive migration from the Eurasian steppe as the prime cause for this event. However, there is a fundamental difference between expressing a Corded Ware identity-the sharing of world views and ideas-and having a specific DNA-profile. Therefore, we argue that investigating the exchange of cultural information on burial rites between these communities serves as a crucial complement to the exchange of biological information. By adopting a practice perspective to 1161 Corded Ware burials throughout north-western Europe, combined with similarity indexes and network representations, we demonstrate a high degree of information sharing on the burial ritual between different regions. Moreover, we show that male burials are much more international in character than female burials and as such can be considered as the vector along which cultural information and Corded Ware identity was transmitted. This finding highlights an underlying complex societal organization of Corded Ware burial rites in which gender roles had a significant impact on the composition and transmission of cultural information. Our findings corroborate recent studies that suggest the Corded Ware was a male focused society.

  5. Neuroanatomical and electrophysiological studies of identified contact chemoreceptors on the ventral ovipositor valve of 3rd instar larvae of lubber grasshoppers (Taeniopoda eques).

    Science.gov (United States)

    Tousson, Ehab

    2004-01-01

    A large number of contact chemoreceptors are located on the ovipositor valves of adult female grasshoppers. These receptors play an important role in many aspects of grasshopper life such as detecting the chemical composition of the soil before and during oviposition. It is surprising, however, to find these types of receptors on the ovipositor valves of instar larvae which are not able to oviposit. Thus, these receptors may serve functions other than to search for a suitable site for egg laying. Observation under the scanning electron microscope revealed the presence of uniporous basiconic contact chemoreceptors in addition to different types of trichoid mechanoreceptors on the ovipositor valve of lubber grasshopper 3rd instar larvae. Neuroanatomical studies have shown that these sensilla are multiply innervated, containing one mechanosensory neuron and four chemosensory neurons that project locally and intersegmentally. The tip recording technique from single basiconic sensilla demonstrated mechanosensory responses to deflections of the sensillum as well as gustatory activity when in contact with different chemical solutions. The electrophysiological studies have shown that these sensilla serve as contact chemoreceptors and not as olfactory receptors.

  6. Evidence of human-induced morphodynamic changes along the Campania coastal areas (southern Italy) since the 3rd-4th cent. AD

    Science.gov (United States)

    Russo Ermolli, Elda; Romano, Paola; Liuzza, Viviana; Amato, Vincenzo; Ruello, Maria Rosaria; Di Donato, Valentino

    2014-05-01

    Campania has always offered suitable climatic and physiographic conditions for human settlements since prehistoric times. In particular, many Graeco-Roman towns developed along its coasts starting from the 7th-6th cent. BC. In the last decade, geoarchaelogical surveys have been carried out in the archaeological excavations of Neapolis, Paestum and Elea-Velia allowing the main steps of the landscape evolution around these towns to be defined in detail. The greek town of Neapolis rose in the late 6th cent. BC [1] on a terrace overlooking a low-relief rocky coast surrounded by volcanic hills. Port activities developed in a protected bay facing the town from the 4th-2nd cent. BC up to the 4th cent. AD, as testified by the discovery of structures and shipwrecks [2, 3, 4]. Starting from the 3rd cent. AD a spit bar formed at the bay entrance causing the progressive establishment of a lagoon which was gradually filled up by alluvial inputs and completely closed in the 5th cent. AD. During the same period, episodes of increased alluvial inputs were also recorded further west along the coast, where a narrow sandy beach formed at the cliff toe. The greek town of Poseidonia, renamed Paestum by the Romans, was founded in the 540 BC on a travertine terrace facing the sandy littoral of a prograding coastal plain [5]. In front of the main town door, a coastal lagoon developed thanks to the growth of a dune ridge and was probably used for harbor activities [5]. After this period the shoreline shifted seawards, another dune ridge formed and the back-ridge depression was filled with fluvial-marshy deposits, slowly drying up. Phases of travertine deposition, which characterized the SE sector of the plain all along the Holocene, were recorded in the northern and southern quarters of the town in historical times and were connected to the abandonment of the town in the early Medieval times. The greek colony of Elea-Velia was located on top of a siliciclastic promontory where the ruins of

  7. The Impact of Comprehensive Agrarian Reform Program (CARP on FarmerBeneficiaries in the 3rd Congressional District of Iloilo, Philippines

    Directory of Open Access Journals (Sweden)

    Ronaldo F. Frufonga

    2016-02-01

    Full Text Available The study aims to assess the impact of the comprehensive agrarian reform program on farmer beneficiaries in the 3rd Congressional District of the province of Iloilo for the year 2014. The Network design was used as research design to obtain and provide useful information in judging decision alternatives involve in the impact of Comprehensive Agrarian Reform Program to the farmerbeneficiaries. The participants were the 386 farmer beneficiaries. Data were gathered using surveychecklist form and analyzed through frequency counts, percentages, mean and t-test of dependent/correlated means. The researcher observed ethical considerations in conducting the study. The results show that the comprehensive agrarian reform program has a positive impact on the lives of the farmer beneficiaries. It has contributed to higher income and led to reduced poverty incidence before and after the program. The beneficiaries tend to be better off in terms of wellbeing compared to before the implementation of the program. They have better access to sanitary toilet facilities and potable water, and have a propensity to have higher educational attainment. Support services became essential in enhancing food security and building infrastructures that uphold food production, enhance trade, and increase income of the household beneficiaries living in the rural community. Further, the household farmer beneficiaries have a propensity to boost the chances to reduce poverty.

  8. Achievement report for fiscal 1994 on developing entrained bed coal gasification power plant. Part 1. Element research edition and technology survey edition; 1994 nendo seika hokokusho. Funryusho sekitan gaska hatsuden plant kaihatsu - Sono 1. Youso kenkyu hen, gijutsu chosa hen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    With an objective of establishing the coal gasification composite power generation technology, R and D has been carried out on the elementary technologies. This paper summarizes the achievements in fiscal 1994. In the research on the large gas turbine combustor for the demonstration plant, combustion tests were carried out by using the actual gas from the designed coal (coal D). In addition, the minimum gas flow rate test, fuel calory change test, and fuel switching test were performed from the viewpoint of evaluating the low load stability. Furthermore, in order to evaluate the combustion performance of the tested combustor, such tests were conducted as the combustor pressure loss characteristics test, bypass valve flow rate characteristics test, light oil ignition and light oil combustion test, and tests on the characteristics to switch from light oil to coal gas and the coal gas combustion characteristics. Evaluations were given on the NOx conversion rate, CO, THC, combustion efficiency, metal temperatures, pattern factors, pressure loss, internal pressure variation, and vibration stress. In the simulation research of the composite power generation system, the simulation models were varied according to the actual plant requirements in association with the progress of the tests on the pilot plant. The results of the simulations were reflected to the general load pressure control equipment. (NEDO)

  9. DNA-free genome editing methods for targeted crop improvement.

    Science.gov (United States)

    Kanchiswamy, Chidananda Nagamangala

    2016-07-01

    Evolution of the next-generation clustered, regularly interspaced, short palindromic repeat/Cas9 (CRISPR/Cas9) genome editing tools, ribonucleoprotein (RNA)-guided endonuclease (RGEN) RNPs, is paving the way for developing DNA-free genetically edited crop plants. In this review, I discuss the various methods of RGEN RNPs tool delivery into plant cells and their limitations to adopt this technology to numerous crop plants. Furthermore, focus is given on the importance of developing DNA-free genome edited crop plants, including perennial crop plants. The possible regulation on the DNA-free, next-generation genome-edited crop plants is also highlighted.

  10. STUDY OF THYROID PROFILE BY USING ULTRA SENSITIVE 3 rd GENERATION THYROID ASSAY IN TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE CENTER

    Directory of Open Access Journals (Sweden)

    Rahul Ladda

    2017-01-01

    Full Text Available BACKGROUND Diabetes mellitus is a common endocrine disorder which is defined as a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Recently few studies have shown that Thyroid dysfunction especially hypothyroidism is found in patients with Type 2 Diabetes Mellitus but the mechanism for this is largely unknown. Unrecognized thyroid dysfunction can impair metabolic control in diabetes and may even exaggerate cardiovascular risk. Prompt detection and treatment may reduce risk derangement of cellular metabolism in diabetes mellitus and help achieving metabolic control in diabetes. AIMS AND OBJECTIVES OF THE STUDY To find the prevalence rate of thyroid disorders in type 2 diabetes mellitus by using 3 rd generation thyroid assay and distribution of thyroid disorders in patients with Type 2 diabetes mellitus MATERIALS AND METHODS 150 patients diagnosed with type 2 diabetes mellitus or newly detected Type 2 diabetes mellitus without thyroid disorders attending outpatient departments and admitted to General medicine wards of Basaveshwar teaching and general hospital were included in this study. RESULTS Of the 150 patients with Diabetes 88 patients (58.66% were male and 62 patients (41.33% were male. The mean age in diabetic group 56.48±11.64 years. 84 patients (54% in Diabetic group had hypertension and 25 patients (16.7% diabetic group had coronary artery disease 43 patients (28.66% had abnormal thyroid profile in diabetic group of which 23 patients (53.5% had subclinical hypothyroidism and 16 patients (37.3 % had overt hypothyroidism 2 (4.6 % patients had subclinical hyperthyroidism and 2 (4.6% had overt hyperthyroidism. CONCLUSION The prevalence (28.8% of thyroid dysfunction was common in type 2 diabetes mellitus patients. Our study shows significant co relation between abnormal thyroid profile and glycaemic control, dyslipidaemia and duration of diabetes.

  11. Challenges in the identification of dead migrants in the Mediterranean: The case study of the Lampedusa shipwreck of October 3rd 2013.

    Science.gov (United States)

    Olivieri, Lara; Mazzarelli, Debora; Bertoglio, Barbara; De Angelis, Danilo; Previderè, Carlo; Grignani, Pierangela; Cappella, Annalisa; Presciuttini, Silvano; Bertuglia, Caterina; Di Simone, Paola; Polizzi, Nicolò; Iadicicco, Agata; Piscitelli, Vittorio; Cattaneo, Cristina

    2018-04-01

    Every year thousands of migrants die during the endeavour to reach the Italian coasts, making the Mediterranean the theatre of one of the greatest tragedies of mankind. Over 60% of these victims is buried unidentified: one of the reasons behind this is related to the specific difficulties and lack of strategies concerning AM and PM data collection. The present article describes how Italy is trying to face the problem of migrant identification, thanks to the collaboration between government, the Italian national police and universities. In particular, this is the first pilot study carried out to identify the victims of the second greatest tragedy of its kind off the Italian coast, near Lampedusa, on October 3rd 2013, which caused 366 victims. The present article shows the strategies conceived to collect postmortem and especially antemortem data and to compare them to identify matches, using medicolegal, anthropological, odontological and genetic approaches. Thirty-one victims out of 53 missing sought by relatives were identified (58.5%). The type and the quality of antemortem data available, generally photos and videos, pinpoints the importance of the face and the body for identification when the bodies are well preserved and how DNA analyses may at times present difficulties. In fact, critical points emerged concerning especially the lack of genetic information of the populations to which the victims belonged, the number of genetic markers needed to reach a statistical support for the identification and the need to adopt lineage markers such as mitochondrial DNA and Y-chromosome polymorphisms to identify parental relationships. This pilot study however has proven that families continue to seek their relatives and that it is possible, as well as mandatory, to identify migrant victims in spite of the difficulties in the collection of antemortem and postmortem data. In addition, considering the peculiar scenario, novel strategies for positive identification have to be

  12. The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

    Science.gov (United States)

    Lehman, Michael N; Coolen, Lique M; Steiner, Robert A; Neal-Perry, Genevieve; Wang, Luhong; Moenter, Suzanne M; Moore, Aleisha M; Goodman, Robert L; Hwa-Yeo, Shel; Padilla, Stephanie L; Kauffman, Alexander S; Garcia, James; Kelly, Martin J; Clarkson, Jenny; Radovick, Sally; Babwah, Andy V; Leon, Silvia; Tena-Sempere, Manuel; Comninos, Alex; Seminara, Stephanie; Dhillo, Waljit S; Levine, Jon; Terasawa, Ei; Negron, Ariel; Herbison, Allan E

    2018-04-14

    The 3 rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction. Based on recent discoveries, the scope of this meeting was expanded to include functions of kisspeptin and related peptides in other physiological systems including energy homeostasis, pregnancy, ovarian and uterine function, and thermoregulation. In addition, discussions addressed the translation of basic knowledge of kisspeptin biology to the treatment of disease, with the goal of seeking consensus about the best approaches to improve human health. The two-day meeting featured a non-traditional structure, with each day starting with poster sessions followed by lunch discussions and facilitated large-group sessions with short presentations to maximize the exchange of new, unpublished data. Topics were identified by a survey prior to the meeting, and focused on major unresolved questions, important controversies, and future directions in the field. Finally, career development activities provided mentoring for trainees and junior investigators, and networking opportunities for those individuals with established researchers in the field. Overall, the meeting was rated as a success by attendees and covered a wide range of lively and provocative discussion topics on the changing nature of the field of "kisspeptinology" and its future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  13. Association between asthma and physical activity in Korean adolescents: the 3rd Korea Youth Risk Behavior Web-based Survey (KYRBWS-III).

    Science.gov (United States)

    Kim, Jae-Woo; So, Wi-Young; Kim, Yeon Soo

    2012-12-01

    Asthma is the leading chronic illness among children and adolescents in several nations. This study investigated the association between asthma and physical activity (PA). The findings in this study are based on the data obtained from the 2007 3rd Korea Youth Risk Behavior Web-Based Survey (KYRBWS-III), a cross-sectional survey of health-risk behaviours among a representative sample of Korean middle- and high-school students aged 13-18 years. This survey is conducted annually by the Korea Centers for Disease Control and Prevention. The 72 943 study subjects were selected using the complex sampling design of the survey. The association between asthma and PA was assessed by conducting multiple logistic regression analyses of the data by using the statistical software SPSS 17.0 Complex Sample. Compared with the adolescents without current asthma, significantly fewer adolescents with current asthma had a sedentary time of 3 h or less per day (odds ratio, 0.86; 95% confidence interval, 0.75-0.97). Sedentary time was defined as time spent watching television, surfing the Internet, or playing computer games and excluded the time spent doing homework or study during leisure time. The analysis was adjusted for age, gender, family affluence level (FAL), obesity, allergic rhinitis, atopy and smoking. With regard to participation in adequate vigorous or moderate PA, strengthening exercise or physical education class, no significant differences were found between the adolescent students with current asthma and those without current asthma. In addition, it was found that all PA had no significant differences in their effects on asthma severity (medication, inability to work and absence from school). Our results show that the amount of sedentary time influenced asthma prevalence; however, PA did not influence asthma prevalence in Korean adolescents.

  14. On the Discovery of Eastern Hellenistic Initiatory Altar of the 3rd – 1st Centuries BC Depicting the Plot of Bull Sacrifice in the City of Stavropol

    Directory of Open Access Journals (Sweden)

    Prokopenko Yuriy A.

    2016-10-01

    Full Text Available The article is devoted to the semantic and chronological analysis of the images on the plate of white tuff discovered in the city of Stavropol. The central part of the relief is occupied with the image of table – an altar with hoisted bull head (in the background and the hanging part of bull skin (in the foreground. Between the protruding edges of the hanging skin and lower to the ground (between the legs of the altar an ancient Greek phrase carved in three lines. The composition is completed by flanking images of two figures in long robes depicted in profile, symmetrically turned to the head of the bull. The figure at the right is an image of a man with a long beard, the lower edge of which is bent forward (priest or king. The figure at the left is a female (queen. Both the man and the woman are holding ritual vessels in hands. The plot of bull sacrifice is typical for the cultural traditions of ancient Greece as well as for ancient eastern states. The fact of combining images and inscriptions peculiar of the Hellenistic culture and ancient Iranian mythology on the Stavropol altar should be associated with the religious policy pursued by the Pontic kings since the second half of the 3rd century BC till the Common Era. This policy was focused on the gradual replacement of local cults by Greek ones in the official pantheon. The reasons for the Asia Minor altar existence in the Stavropol Upland include: 1 the military expeditions of the Sarmatians to Asia Minor in 2nd – 1st centuries BC; 2 the establishment of political and economic ties by the North Caucasus population with the state of Seleucids in the 2nd century BC, with Parthia in the 2nd – 1st centuries BC, and especially with the kingdom of Pontus in the 1st century BC.

  15. The Study of Compound Quality of various Siam Weed (Eupatorium odoratum) Extracts and Toxicity Detoxification mechanisms Against 3rd Instar Larvae of Fruit Fly (Dacus dorsalis)

    International Nuclear Information System (INIS)

    Sutthivaiyakit, Pakawadee; Visetson, Suraphon; Sutthivaiyakit, Somyote; Patharakorn, Thipamon; Patharakorn, Surapol; Piadang, Patharakorn

    2006-09-01

    The 1H-NMR spectroscopy showed signals of DeltaH tild0.71.6 from hexane-leaf extracts from Siam weed (Eupatorium odoratum) These signals derive from protons of non-polar compounds which include fatty acid residues and terpinoids. In addition, the amplification of the signals indicated of some minor DeltaH tild6.2-7.7. This revealed protons from aromatic rings possibly involving in flavonoids from 1H-NMR spectrum. This is a believe that is a believe that these compounds could be varied from slightly polar compounds to moderately polar compounds. Furthermore, the Thin Layer Chromatography (TLC) of hexane, chloroform and methanol fractions showed the extracts composed of majority of less polar. It is and indication of the method of separation is quite food for separation of polarity basis from these extracts. Finally, the TLC of hexane fraction distinctively produced 7-8 compounds from the extracts. Toxicity testing using topical spray method showed that methnoloc extracts gave highest toxicity against 3rd instar larvae of fruit fly (Darcus dorsalis). The root extracts produced ca. 5 fold mohile GSH-S-transferase ws elevated 2-3 fold. The addition of dimethyl maleate into the extraccts increased their toxicity. The persistent experiment of eupathal from the extracts showed that the extracts can be stabilixed under aqueous solution upto 1 month with losing the compound. Finally, the Siam weed extracts prosuced non toxic to non-target organisms such as gabbies, bee, and mouse. The results of LC50 showed 15,000-26,000 mg/L 6,000-15,000 mg/L and 3,000-10,000 mg/L from hexane, chloroform and methanol extracts, respectively.

  16. Animal Board Invited Review: Sheep birth distribution in past herds: a review for prehistoric Europe (6th to 3rd millennia BC).

    Science.gov (United States)

    Balasse, M; Tresset, A; Bălăşescu, A; Blaise, E; Tornero, C; Gandois, H; Fiorillo, D; Nyerges, É Á; Frémondeau, D; Banffy, E; Ivanova, M

    2017-12-01

    In temperate latitudes sheep have a seasonal reproductive behaviour, which imposes strong constraints on husbandry in terms of work organization and availability of animal products. During the last 50 years, researchers have focused on understanding the mechanisms driving small ruminants' reproduction cycles and finding ways to control them. This characteristic is inherited from their wild ancestor. However, the history of its evolution over the 10 millennia that separates present day European sheep from their Near Eastern ancestors' remains to be written. This perspective echoes archaeologists' current attempts at reconstructing ancient pastoral societies' socio-economical organization. Information related to birth seasonality may be retrieved directly from archaeological sheep teeth. The methodology consists of reconstructing the seasonal cycle record in sheep molars, through sequential analysis of the stable oxygen isotope composition (δ 18O) of enamel. Because the timing of tooth development is fixed within a species, inter-individual variability in this parameter reflects birth seasonality. A review of the data obtained from 10 European archaeological sites dated from the 6th to the 3rd millennia BC is provided. The results demonstrate a restricted breeding season for sheep: births occurred over a period of 3 to 4 months, from late winter to early summer at latitudes 43°N to 48°N, while a later onset was observed at a higher latitude (59°N). All conclusions concurred with currently held expectations based on present day sheep physiology, which, aside from the historical significance, contributes to the reinforcing of the methodological basis of the approach. Further study in this area will permit regional variability attributable to technical choices, within global schemes, to be fully reported.

  17. 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning

    CERN Document Server

    Prieta, Fernando; Mascio, Tania; Gennari, Rosella; Rodríguez, Javier; Vittorini, Pierpaolo

    2016-01-01

    The 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning held in Seville (Spain) is host by the University of Seville from 1st to 3rd June, 2016. The 6th edition of this conference expands the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions or web-based ones. It intends to bring together researchers and developers from industry, the education field and the academic world to report on the latest scientific research, technical advances and methodologies.

  18. The NMC Horizon Report: 2013 Museum Edition

    Science.gov (United States)

    Johnson, L.; Adams Becker, S.; Freeman, A.

    2013-01-01

    The "NMC Horizon Report: 2013 Museum Edition," is a co-production with the Marcus Institute for Digital Education in the Arts (MIDEA), and examines six emerging technologies for their potential impact on and use in education and interpretation within the museum environment: BYOD (Bring Your Own Device), crowdsourcing, electronic…

  19. Introduction to Energy - 2nd Edition

    Science.gov (United States)

    Cassedy, Edward S.; Grossman, Peter Z.

    1998-12-01

    Energy issues such as pollution, resource depletion, global warming, nuclear power and waste are problems that demand timely solutions. This book provides a critical examination of the resources, market forces, and social impacts of modern energy production. The book addresses the dilemmas that have arisen due to society's crucial dependence on energy, particularly fossil fuels, and explores the available alternative energy producing technologies. The second edition has increased emphasis on those issues at the forefront of the current energy debate: energy sustainability, climate change, and the radical restructuring of the power industry due to de-regulation. Assuming no prior technical expertise and avoiding complex mathematical formulation, it is directed at a broad readership. The second edition will follow the first in proving especially useful as a textbook for undergraduate programs in Science, Technology and Society (STS), and as a supplementary text in a variety of courses which touch upon energy studies, including environmental and technology policy, environmental, mineral and business law, energy and resource economics. Fully updated second edition of successful first edition that was adopted on Science, Technology and Society courses Provides a critical examination of all aspects of modern energy production for non-technical readers For a broad readership from a variety of backgrounds

  20. Precision genome editing in the CRISPR era.

    Science.gov (United States)

    Salsman, Jayme; Dellaire, Graham

    2017-04-01

    With the introduction of precision genome editing using CRISPR-Cas9 technology, we have entered a new era of genetic engineering and gene therapy. With RNA-guided endonucleases, such as Cas9, it is possible to engineer DNA double strand breaks (DSB) at specific genomic loci. DSB repair by the error-prone non-homologous end-joining (NHEJ) pathway can disrupt a target gene by generating insertions and deletions. Alternatively, Cas9-mediated DSBs can be repaired by homology-directed repair (HDR) using an homologous DNA repair template, thus allowing precise gene editing by incorporating genetic changes into the repair template. HDR can introduce gene sequences for protein epitope tags, delete genes, make point mutations, or alter enhancer and promoter activities. In anticipation of adapting this technology for gene therapy in human somatic cells, much focus has been placed on increasing the fidelity of CRISPR-Cas9 and increasing HDR efficiency to improve precision genome editing. In this review, we will discuss applications of CRISPR technology for gene inactivation and genome editing with a focus on approaches to enhancing CRISPR-Cas9-mediated HDR for the generation of cell and animal models, and conclude with a discussion of recent advances and challenges towards the application of this technology for gene therapy in humans.

  1. Genome Editing Gene Therapy for Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Hotta, Akitsu

    2015-09-22

    Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by loss of function of the dystrophin gene on the X chromosome. Gene augmentation of dystrophin is challenging due to the large size of the dystrophin cDNA. Emerging genome editing technologies, such as TALEN and CRISPR-Cas9 systems, open a new erain the restoration of functional dystrophin and are a hallmark of bona fide gene therapy. In this review, we summarize current genome editing approaches, properties of target cell types for ex vivo gene therapy, and perspectives of in vivo gene therapy including genome editing in human zygotes. Although technical challenges, such as efficacy, accuracy, and delivery of the genome editing components, remain to be further improved, yet genome editing technologies offer a new avenue for the gene therapy of DMD.

  2. Genome Editing Redefines Precision Medicine in the Cardiovascular Field

    Directory of Open Access Journals (Sweden)

    Elda Dzilic

    2018-01-01

    Full Text Available Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1 the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2 the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies.

  3. Quantifying on- and off-target genome editing.

    Science.gov (United States)

    Hendel, Ayal; Fine, Eli J; Bao, Gang; Porteus, Matthew H

    2015-02-01

    Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. While the ability to make precise and controlled changes at specified sites throughout the genome has grown tremendously in recent years, we still lack a comprehensive and standardized battery of assays for measuring the different genome editing outcomes created at endogenous genomic loci. Here we review the existing assays for quantifying on- and off-target genome editing and describe their utility in advancing the technology. We also highlight unmet assay needs for quantifying on- and off-target genome editing outcomes and discuss their importance for the genome editing field. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. CRISPR Genome Editing

    Science.gov (United States)

    A research article about a technique for gene editing known as CRISPR-Cas9. The technique has made it much easier and faster for cancer researchers to study mutations and test new therapeutic targets.

  5. Decimal Classification Editions

    Directory of Open Access Journals (Sweden)

    Zenovia Niculescu

    2009-01-01

    Full Text Available The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  6. Developing new levels of edit

    Energy Technology Data Exchange (ETDEWEB)

    Prono, J.K.

    1997-06-01

    Since 1985, Los Alamos National Laboratory (LANL) staff have had four levels of edit to choose from for technical reports. When a CQI survey showed that both authors and editors felt the levels were not meeting author needs, LANL set about revising them. The goals were to simplify the editing process, focus editing on improving technical clarity, and ensure value added in editing. This paper describes the revision process and product--three author-based levels of edit.

  7. Genome editing and assisted reproduction: curing embryos, society or prospective parents?

    OpenAIRE

    Cavaliere, Giulia

    2017-01-01

    This paper explores the ethics of introducing genome-editing technologies as a new reproductive option. In particular, it focuses on whether genome editing can be considered a morally valuable alternative to preimplantation genetic diagnosis (PGD). Two arguments against the use of genome editing in reproduction are analysed, namely safety concerns and germline modification. These arguments are then contrasted with arguments in favour of genome editing, in particular with the argument of the c...

  8. The OIT Times, Fall 2000 edition, Vol. 3, No. 4

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, L.

    2000-09-19

    This is the Fall 2000 edition of the OIT Times newsletter, a 12-page quarterly publication produced by the Office of Industrial Technologies. This issue focuses on OIT's BestPractices initiative.

  9. Ověření vlastností webových technologií Java Enterprise Edition a Node.js

    OpenAIRE

    SZABO, Michal

    2017-01-01

    This bachelor thesis deals with verification of capabilities of internet technologies Java EE and Node.js. First part contains description of different models of client´s processed demands. If further contains desing of application´s functionality which is later implemented in both technologies. End of this thesis contains general recommendations that are based on author´s progress.

  10. Transportation Energy Data Book, Edition 19

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    1999-09-01

    The Transportation Energy Data Book: Edition 19 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (http://www-cta.ornl.gov/data/tedb.htm).

  11. Genome Editing in Human Pluripotent Stem Cells.

    Science.gov (United States)

    Carlson-Stevermer, Jared; Saha, Krishanu

    2017-01-01

    Genome editing in human pluripotent stem cells (hPSCs) enables the generation of reporter lines and knockout cell lines. Zinc finger nucleases, transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9 technology have recently increased the efficiency of proper gene editing by creating double strand breaks (DSB) at defined sequences in the human genome. These systems typically use plasmids to transiently transcribe nucleases within the cell. Here, we describe the process for preparing hPSCs for transient expression of nucleases via electroporation and subsequent analysis to create genetically modified stem cell lines.

  12. Book Review: New Perspectives on Technical Editing

    Science.gov (United States)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer

  13. Genome Editing of Monogenic Neuromuscular Diseases

    Science.gov (United States)

    Long, Chengzu; Amoasii, Leonela; Bassel-Duby, Rhonda; Olson, Eric N.

    2017-01-01

    , were also reviewed. FINDINGS Multiple proof-of-concept studies reveal the feasibility and efficacy of genome-editing–meditated correction of monogenic neuromuscular diseases in cultured cells and animal models. CONCLUSIONS AND RELEVANCE Genome editing is a rapidly evolving technology with enormous translational potential once efficacy, delivery, and safety issues are addressed. The clinical impact of this technology is that genome editing can permanently correct disease-causing mutations and circumvent the hurdles of traditional gene- and cell-based therapies. PMID:27668807

  14. Genome editing in fishes and their applications.

    Science.gov (United States)

    Zhu, Bo; Ge, Wei

    2018-02-01

    There have been revolutionary progresses in genome engineering in the past few years. The newly-emerged genome editing technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats associated with Cas9 (CRISPR/Cas9) have enabled biological scientists to perform efficient and precise targeted genome editing in different species. Fish represent the largest group of vertebrates with many species having values for both scientific research and aquaculture industry. Genome editing technologies have found extensive applications in different fish species for basic functional studies as well asapplied research in such fields as disease modeling and aquaculture. This mini-review focuses on recent advancements and applications of the new generation of genome editing technologies in fish species, with particular emphasis on their applications in understanding reproductive functions because the reproductive axis has been most systematically and best studied among others and its function has been difficult to address with reverse genetics approach. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. A «titulus pictus» with an imperial mention in «Carthago Nova» and some considerations concerning the urban dynamics of the city in the early 3rd century ad

    Directory of Open Access Journals (Sweden)

    José Miguel NOGUERA CELDRÁN

    2017-06-01

    Full Text Available The archaeological and epigraphic record in Carthago Nova suggests that the colony underwent a period of instability and urban retreat during the second half of the 2nd and the 3rd century ad. This was probably triggered by the slowing down of economic activity, a shrinking population and collapse of local institutions and the crisis of evergetism. The process caused a substantial transformation of urban landscapes and a reduction of the size of the inhabited areas; the interruption of the epigraphic habit, the abandonment, looting and reoccupation of public areas and buildings; the pulling down of domestic buildings; and the insufficient maintenance of the urban road network. This has led some specialists to suggest that the city lost importance, and even that it could have been totally abandoned during the second half of the 2nd and, especially, the 3rd century ad. The recent discovery of the substantial transformation of the Atrium Building (Insula i Molinete in the early 3rd century ad, and of a titulus pictus which mentions the consuls for the year, Heliogabalus and the prefect of the praetorium Adventus, which dates the final date for the refectio in 218 ad, resituates the debate around the retreat of the urban centre in the 2nd and 3rd centuries ad.

  16. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report

    NARCIS (Netherlands)

    Kager, L.; Whelan, J.; Dirksen, U.; Hassan, B.; Anninga, J.; Bennister, L.; Bovee, J.V.; Brennan, B.; Broto, J.M.; Brugieres, L.; Cleton-Jansen, A.M.; Copland, C.; Dutour, A.; Fagioli, F.; Ferrari, S.; Fiocco, M.; Fleuren, E.D.; Gaspar, N.; Gelderblom, H.; Gerrand, C.; Gerss, J.; Gonzato, O.; Graaf, W.T. van der; Hecker-Nolting, S.; Herrero-Martin, D.; Klco-Brosius, S.; Kovar, H.; Ladenstein, R.; Lancia, C.; Ledeley, M.C.; McCabe, M.G.; Metzler, M.; Myklebost, O.; Nathrath, M.; Picci, P.; Potratz, J.; Redini, F.; Richter, G.H.; Reinke, D.; Rutkowski, P.; Scotlandi, K.; Strauss, S.; Thomas, D; Tirado, O.M.; Tirode, F.; Vassal, G.; Bielack, S.S.

    2016-01-01

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children's Cancer Research Institute in Vienna, Austria on September 24-25, 2015. The joint bone sarcoma network meetings bring together

  17. One small edit for humans, one giant edit for humankind? Points and questions to consider for a responsible way forward for gene editing in humans.

    Science.gov (United States)

    Howard, Heidi C; van El, Carla G; Forzano, Francesca; Radojkovic, Dragica; Rial-Sebbag, Emmanuelle; de Wert, Guido; Borry, Pascal; Cornel, Martina C

    2018-01-01

    Gene editing, which allows for specific location(s) in the genome to be targeted and altered by deleting, adding or substituting nucleotides, is currently the subject of important academic and policy discussions. With the advent of efficient tools, such as CRISPR-Cas9, the plausibility of using gene editing safely in humans for either somatic or germ line gene editing is being considered seriously. Beyond safety issues, somatic gene editing in humans does raise ethical, legal and social issues (ELSI), however, it is suggested to be less challenging to existing ethical and legal frameworks; indeed somatic gene editing is already applied in (pre-) clinical trials. In contrast, the notion of altering the germ line or embryo such that alterations could be heritable in humans raises a large number of ELSI; it is currently debated whether it should even be allowed in the context of basic research. Even greater ELSI debates address the potential use of germ line or embryo gene editing for clinical purposes, which, at the moment is not being conducted and is prohibited in several jurisdictions. In the context of these ongoing debates surrounding gene editing, we present herein guidance to further discussion and investigation by highlighting three crucial areas that merit the most attention, time and resources at this stage in the responsible development and use of gene editing technologies: (1) conducting careful scientific research and disseminating results to build a solid evidence base; (2) conducting ethical, legal and social issues research; and (3) conducting meaningful stakeholder engagement, education and dialogue.

  18. Establishment of reference values in a healthy population and interpretation of serum PTH concentrations in hemodialyzed patients according to the KDIGO Guidelines using the Lumipulse® G whole PTH (3rd generation) assay.

    Science.gov (United States)

    Cavalier, Etienne; Salsé, Margot; Dupuy, Anne-Marie; Bargnoux, Anne-Sophie; Watar, Florence; Souberbielle, Jean-Claude; Delanaye, Pierre; Cristol, Jean-Paul

    2018-04-01

    3rd generation PTH assays only detect the bioactive 1-84 fragment. Since standardization is still lacking, each new PTH assay requires to establish reference values and to assess the impact in the medical care of the mineral and bone disorders in hemodialyzed patients. Using Fujirebio Lumipulse G wPTH assay, serum PTH levels were measured in a population of 439 healthy subjects from France and Belgium PTH levels were also determined in 119 hemodialyzed patients. These patients were classified according to the KDIGO recommendation. Reference range was found to be 6.5 (90%CI: 6.0-7.0) - 41.8 (90% CI: 38.1-43.7). In hemodialysis patients, Passing-Bablock regression between 3rd generation PTH from Fujirebio and DiaSorin was DiaSorin = 1.01 xFujirebio-2.4 with a slope not different from 1.0(95%CI: 0.96-1.04) and a non-significant intercept, ranging from -6.0 to 0.1. Hemodialysis patients with a PTH concentration below 2-fold the Upper Limit of Normality (ULN), within the KDIGO range and upper 9-fold upper limit were respectively 33.6%, 54.6%, 11.8% (Fujirebio Lumipulse) and 36.1%, 51.3% and 12.6% (Diasorin Liaison). We determined a reference range with the 3rd generation PTH assay from Fujirebio. In a hemodialysis population, 3rd generation assays from Fujirebio and DiaSorin provide similar results. To the best of our knowledge, this is the first time that we can show similar PTH results obtained by 2 different 3rd generation PTH assays in healthy subjects and hemodialyzed patients without mathematically processing them. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  19. Salient Features of Endonuclease Platforms for Therapeutic Genome Editing.

    Science.gov (United States)

    Certo, Michael T; Morgan, Richard A

    2016-03-01

    Emerging gene-editing technologies are nearing a revolutionary phase in genetic medicine: precisely modifying or repairing causal genetic defects. This may include any number of DNA sequence manipulations, such as knocking out a deleterious gene, introducing a particular mutation, or directly repairing a defective sequence by site-specific recombination. All of these edits can currently be achieved via programmable rare-cutting endonucleases to create targeted DNA breaks that can engage and exploit endogenous DNA repair pathways to impart site-specific genetic changes. Over the past decade, several distinct technologies for introducing site-specific DNA breaks have been developed, yet the different biological origins of these gene-editing technologies bring along inherent differences in parameters that impact clinical implementation. This review aims to provide an accessible overview of the various endonuclease-based gene-editing platforms, highlighting the strengths and weakness of each with respect to therapeutic applications.

  20. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption......Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...