WorldWideScience

Sample records for tech prep consortia

  1. Tech Prep and the Rural Context.

    Science.gov (United States)

    Roth, Gene L.

    1996-01-01

    Discusses implementation of tech prep in rural areas and notes that relatively little research has been done on behalf of small town schools. Teachers' comments regarding tech prep implementation provide additional insight into the situation. (JOW)

  2. Planning a Tech Prep Program in Hospitality. Final Report.

    Science.gov (United States)

    Chicago City Colleges, IL. Chicago City-Wide Coll.

    A project conducted to establish tech prep articulation training agreements between City Colleges of Chicago and several public secondary schools is described in this report. Project activities were as follows: (1) developed a handbook to define the tech prep experience and guide committee members on how tech prep can be a valuable asset to…

  3. Prep/Tech: Volume 1, No. 1, Youth on homelessness

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    PREP/TECH is a skill development, academic enrichment program of U. of Toledo in Toledo OH and The Engineers Foundation of Ohio; it addresses the mathematics, science, language, and intellectual needs of about 100 African-American and Hispanic-American 7th, 8th, and 9th graders in Toledo. This summer, after 3 weeks of classes, the 80 students returned for a second 3 week session and were divided into two groups, one studying the growing problem of homelessness in America. This group researched and published a pamphlet on homelessness. This report is divided into: myths, causes, descriptions, and solutions. Finally, a brief account is given of the homelessness project.

  4. How To Implement a Tech Prep Program Based on the Rhode Island Model. Tech Prep Associate Degree Program. Technical Programs. Business/Office Administration Programs. Allied Health/Dental Health Programs.

    Science.gov (United States)

    Community Coll. of Rhode Island, Warwick.

    This implementation guide contains information based on experiences that occurred during the development and implementation of the Rhode Island Tech Prep Model. It is intended to assist educators in addressing challenges and obstacles faced by the program early in the planning process. It begins with a rationale for tech prep. Rhode Island…

  5. Restructuring Student Experiences Using Tech Prep Mapping To Integrate Vocational and Academic Curriculum.

    Science.gov (United States)

    Pirozzoli, Don

    The growing emphasis on accountability and the demand for better prepared students is pressing institutions of higher education to examine restructuring. Student experiences represent an important arena for school restructuring, and a useful approach to changing student experiences is the Tech Prep Mapping (TPM) process. The TPM process requires…

  6. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  7. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  8. Lecture to inquiry: The transformation of a tech prep biology teacher

    Science.gov (United States)

    Haskell, Deborah Harris

    As teachers implement the National Science Education Standards (NRC, 1996) many have to reform the instructional methods they have used throughout their careers. This case study examines the transformation of Laurie, a 20-year teacher, during her first year of change from a "traditional" textbook/lecture style of teaching to a facilitator of an inquiry-based classroom. Implementing change requires not only pedagogical expertise, but also the belief that the modifications can be made and that the outcomes are significant. Using Bandura's social cognitive theory as a framework, changes in Laurie's self-efficacy, outcome expectancy, and motivation are followed throughout the transition. During her first year of change, Laurie used worksheets, small group activities, and guided inquiry activities, all strategies in which she had high self-efficacy and experienced positive student outcomes. She rarely used class forums, authentic assessment, and formative assessment. Factors that influenced her change were experiential professional development opportunities that allowed her to practice inquiry-based techniques, a change in her teaching environment from college prep chemistry to tech prep biology, autonomy regarding classroom decisions, and reflective decision making as she learned through experience. Using a standards-based biology textbook increased her self-efficacy toward using inquiry-based practices. The textbook format of embedding text in activities rather than adding activities to the text resulted in an increase of the number and frequency of activities done. Facilitating the textbook's Guided Inquiries and Extended Inquiries helped Laurie gain experience with inquiry-based methods. She also realized that when building from the students' concrete experiences, her students were able to attain higher-level thinking skills. The study revealed six factors contributing to Laurie's change process: (a) experiential professional development, (b) motivation for change

  9. High Schools that Work and Tech Prep: Improving Student Performance in Basic Skills.

    Science.gov (United States)

    Flowers, Jim

    2000-01-01

    Test results for 244 agricultural education students in High Schools that Work (HSTW) sites in North Carolina indicated that, compared to all students at HSTW sites and to college-prep students, they failed to meet HSTW goals in math, reading, and science but were making progress. Their math and science performance was higher than other vocational…

  10. ACT Verbal Prep Course

    CERN Document Server

    Standridge, Nathan

    2012-01-01

    Comprehensive Prep for ACT Verbal. Every year, students pay 1,000 and more to test prep companies to prepare for the verbal sections of the ACT. Now you can get the same preparation in a book. The verbal sections are not easy. There is no quick fix that will allow you to "beat" the ACT, but it is very learnable. If you study hard and master the techniques in this book, your score will improve-significantly. The ACT cannot be "beaten." But it can be mastered-through hard work, analytical thought, and by training yourself to think like a test writer. Many of the exercises in this book are design

  11. SAT math prep course

    CERN Document Server

    Kolby, Jeff

    2011-01-01

    Comprehensive Prep for SAT Math Every year, students pay 1,000 and more to test prep companies to prepare for the math section of the new SAT. Now you can get the same preparation in a book. Features: * Comprehensive Review: Twenty-three chapters provide complete review of SAT math. * Practice: Includes 164 examples and more than 500 exercises! Arranged from easy to medium to hard to very hard. * Diagnostic Test: The diagnostic test measures your strengths and weaknesses and directs you to areas you need to study more. * Performance: If your target is a 700+ score, this is the book!

  12. PMP exam prep

    CERN Document Server

    Mulcahy, Rita

    2013-01-01

    This book has been FULLY updated to reflect PMI's changes to the PMP exam, and should be used to prepare for all PMP exams delivered on or after July 30th of 2013. Can you imagine valuing a book so much that you send the author a Thank You letter? Hundreds of thousands of project managers know and understand why PMP Exam Prep is a worldwide best-seller. Years of PMP exam preparation experience, endless hours of ongoing research, interviews with project managers who failed the exam to identify gaps in their knowledge, and a razor-sharp focus on making sure project managers don't waste a single minute of their time studying are THE reasons this book is the best-selling PMP exam preparation guide in the world. PMP Exam Prep, Eighth Edition contains hundreds of updates and improvements from previous editions--including new exercises and sample questions never before in print. Offering hundreds of sample questions, critical time-saving tips plus games and activities available nowhere else, this book will help y...

  13. Library Consortia in Developing Countries: An Overview

    Science.gov (United States)

    Moghaddam, Golnessa Galyani; Talawar, V. G.

    2009-01-01

    Purpose: The purpose of this paper is to review consortia efforts in developing countries. Design/methodology/approach: This paper reviews the literature on library consortia in developing countries in general and India in particular. The paper also outlines the advantages and disadvantages of consortia. Findings: "Library consortia"…

  14. Library Consortia in Developing Countries: An Overview

    Science.gov (United States)

    Moghaddam, Golnessa Galyani; Talawar, V. G.

    2009-01-01

    Purpose: The purpose of this paper is to review consortia efforts in developing countries. Design/methodology/approach: This paper reviews the literature on library consortia in developing countries in general and India in particular. The paper also outlines the advantages and disadvantages of consortia. Findings: "Library consortia"…

  15. High Tech

    OpenAIRE

    Manterola, Javier; Fernández Casado, S.A., Carlos

    1987-01-01

    "High Tech" is an architectural movement that emphasizes the technological dimension of the building as expression means. Its research includes the diverse structures composing the building: resistance, closing, services, distribution and communications. Its results are unequal since not all the buildings rising from this movement are high technology and already are other buildings not enrolled in this movement. Renzo Piano, Richard Rogers and Norman Foster are its main representatives.

  16. Libraries in Finland Establish Consortia

    Directory of Open Access Journals (Sweden)

    Esko Häkli

    2001-07-01

    Full Text Available I will discuss the development of organized consortia, which are based on a charter or a written contract. I will also deal with some issues related to the organization of the consortia. I would already here like to stress, that if a consortium wants to achieve results it, in addition to a charter or a contract, also needs an executive body that carries out the work and makes sure that the plans and decisions are not only prepared but also put into practice. One of the main weaknesses of many cooperative arrangements between libraries has been the absence of a common executive not only taking care of the practicalities but also safeguarding the continuity. A committee can never fulfill the tasks of an executive body because running a consortium successfully requires much more effort than what is normally anticipated. In Finland the National Library has been given the task to enhance the cooperation between the research libraries of the country and to support their consortia . According to the National Library Strategy (adopted in November 1999 the Library is functioning as a common resource of the country’s research libraries. In this capacity it has been instrumental in creating the comprehensive consortia described below and is also responsible for running their daily business. It is possible that an arrangement of this kind is more typical for a small country than for a bigger one.

  17. High Tech

    Directory of Open Access Journals (Sweden)

    Manterola, Javier

    1987-02-01

    Full Text Available "High Tech" is an architectural movement that emphasizes the technological dimension of the building as expression means. Its research includes the diverse structures composing the building: resistance, closing, services, distribution and communications. Its results are unequal since not all the buildings rising from this movement are high technology and already are other buildings not enrolled in this movement. Renzo Piano, Richard Rogers and Norman Foster are its main representatives.

    "High Tech" es un movimiento arquitectónico que enfatiza la dimensión tecnológica del edificio como medio de expresión. Su investigación se fija en las diversas estructuras que configuran el edificio, la resistente, la de cerramiento, la de servicios, la de distribución y comunicaciones. Sus resultados son desiguales pues no todos los edificios que surgen de este movimiento son alta tecnología y muchos otros no inscritos en dicho movimiento sí lo son. Renzo Piano, Richard Rogers y Norman Foster son sus representantes más destacados.

  18. Pyrite oxidation by microbial consortia

    Science.gov (United States)

    Bostick, B. C.; Revill, K. L.; Doyle, C.; Kendelewicz, T.; Brown, G. E.; Spormann, A. M.; Fendorf, S.

    2003-12-01

    Acid mine drainage (AMD) is formed through pyrite oxidation, which produces acidity and releases toxic metals associated with pyrite and other sulfide minerals. Microbes accelerate pyrite oxidation markedly, thereby playing a major role in the production of AMD. Here, we probe pyrite oxidation by consortia of Thiobacillus ferrooxidans and thiooxidans using surface-sensitive photoelectron spectroscopy and X-ray absorption spectroscopy and compare them with surfaces oxidized through chemical and single species cultures. Microbial oxidation resulted in the formation of distinct oxidized surface species distributed non-uniformly over the pyrite surface; consortia produced a surface both more heterogeneous and more oxidized. In contrast, chemical oxidation proceeds without the build-up of passivating oxidation products. Surface morphology was not correlated with sites of nucleation or oxidation in any obvious manner. These results demonstrate that microbial oxidation occurs through a similar mechanism to chemical oxidation, but that the presence of complex microbial communities may impact the manner by which pyrite oxidation proceeds.

  19. Consortia based production of biochemicals

    DEFF Research Database (Denmark)

    Ingemann Jensen, Sheila; Sukumara, Sumesh; Özdemir, Emre

    -based modelling, and state-of-the art metabolic engineering tools to develop a consortium of cells capable of efficient valorization of synthetic hemicellulosic hydrolysate. Stable co-existence and effective covalorization was achieved through niche-differentiation, auxotrophy, and adaptive evolution. In another...... study, stable consortia based fermentation was achieved through niche partitioning, syntrophy (auxotrophy combined with removal of inhibitory side product), and CRISPRi mediated gene silencing. The achieved results demonstrate that consortium based approaches for valorizing complex biomass and waste...

  20. Understanding construction consortia: Theory, practice and opinions

    OpenAIRE

    Gruneberg, S.; Hughes, W. P.

    2006-01-01

    Firms form consortia in order to win contracts. Once a project has been awarded to a consortium each member then concentrates on his or her own contract with the client. Therefore, consortia are marketing devices, which present the impression of teamworking, but the production process is just as fragmented as under conventional procurement methods. In this way, the consortium forms a barrier between the client and the actual construction production process. Firms form consortia, not as a simp...

  1. Library Purchasing Consortia in the UK

    Directory of Open Access Journals (Sweden)

    David Ball

    2001-07-01

    Full Text Available The distribution of library purchasing consortia across the United Kingdom is uneven and sector-dependent. Only higher education libraries show a well developed regional infrastructure of purchasing consortia covering virtually all eligible libraries. While there are clear sectoral disparities amongst the library purchasing consortia surveyed, the size of consortium expenditure seems to determine whether procurement professionals are involved. Thus in those whose spend consistently exceeds European Commission guidelines’ thresholds, the involvement of purchasing professionals is much more likely, and also crucial to the successful navigation of such procedures.

  2. PrEP: controversy, agency and ownership

    National Research Council Canada - National Science Library

    Cairns, Gus P; Race, Kane; Goicochea, Pedro

    2016-01-01

    Pre‐exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need...

  3. Pre-Exposure Prophylaxis (PrEP)

    Science.gov (United States)

    ... Sites Podcasts QR Codes RSS Feeds Social Bookmarking Social Network Sites Text Messaging Twitter Video Games Video Sharing ... PrEP be considered for people who are HIV-negative and at very high risk for HIV infection . ...

  4. PrEP: controversy, agency and ownership

    OpenAIRE

    Cairns, Gus P; Kane Race; Pedro Goicochea

    2016-01-01

    Pre-exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need of it. These controversies extend beyond the intrinsically complex issues of making it available. In this commentary, some of the possible roots of the air of dissent and drama that accompanies PrEP are explored. The similarities between the controversies that dogged the earliest human tr...

  5. Engineering microbial consortia for controllable outputs

    Energy Technology Data Exchange (ETDEWEB)

    Lindemann, Stephen R.; Bernstein, Hans C.; Song, Hyun-Seob; Fredrickson, Jim K.; Fields, Matthew W.; Shou, Wenying; Johnson, David R.; Beliaev, Alexander S.

    2016-03-11

    Much research has been invested into engineering microorganisms to perform desired biotransformations; nonetheless, these efforts frequently fall short of expected results due to the unforeseen effects of biofeedback regulation and functional incompatibility. In nature, metabolic function is compartmentalized into diverse organisms assembled into resilient consortia, in which the division of labor is thought to lead to increased community efficiency and productivity. Here, we consider whether and how consortia can be designed to perform bioprocesses of interest beyond the metabolic flexibility limitations of a single organism. Advances in post-genomic analysis of microbial consortia and application of high-resolution global measurements now offer the promise of systems-level understanding of how microbial consortia adapt to changes in environmental variables and inputs of carbon and energy. We argue that when combined with appropriate modeling framework that predictive knowledge generates testable hypotheses and orthogonal synthetic biology tools, such understanding can dramatically improve our ability to control the fate and functioning of consortia. In this article, we articulate our collective perspective on the current and future state of microbial community engineering and control while placing specific emphasis on ecological principles that promote control over community function and emergent properties.

  6. Indian Consortia Models: FORSA Libraries' Experiences

    Science.gov (United States)

    Patil, Y. M.; Birdie, C.; Bawdekar, N.; Barve, S.; Anilkumar, N.

    2007-10-01

    With increases in prices of journals, shrinking library budgets and cuts in subscriptions to journals over the years, there has been a big challenge facing Indian library professionals to cope with the proliferation of electronic information resources. There have been sporadic efforts by different groups of libraries in forming consortia at different levels. The types of consortia identified are generally based on various models evolved in India in a variety of forms depending upon the participants' affiliations and funding sources. Indian astronomy library professionals have formed a group called Forum for Resource Sharing in Astronomy and Astrophysics (FORSA), which falls under `Open Consortia', wherein participants are affiliated to different government departments. This is a model where professionals willingly come forward and actively support consortia formation; thereby everyone benefits. As such, FORSA has realized four consortia, viz. Nature Online Consortium; Indian Astrophysics Consortium for physics/astronomy journals of Springer/Kluwer; Consortium for Scientific American Online Archive (EBSCO); and Open Consortium for Lecture Notes in Physics (Springer), which are discussed briefly.

  7. Design Tech High School: d.tech

    Science.gov (United States)

    EDUCAUSE, 2015

    2015-01-01

    A Bay Area charter high school, d.tech develops "innovation-ready" students by combining content knowledge with the design thinking process while fostering a sense of autonomy and purpose. The academic model is grounded in self-paced learning through a flex schedule, high standards, and design thinking through a four-year design…

  8. 78 FR 20665 - Pediatric Device Consortia Grant Program

    Science.gov (United States)

    2013-04-05

    ..., prototyping, preclinical, clinical, manufacturing, marketing, and commercialization. The consortia are expected to support a mix of projects at all stages of development, particularly the later stages of clinical, manufacturing, and marketing. ] Specifically, the consortia will facilitate the...

  9. Attributes and Dynamic Development Phases of Informal ICT Consortia

    OpenAIRE

    Pohlmann, Tim

    2010-01-01

    Theoretical and empirical analyses about informal consortia are not yet able to entirely illustrate the informal standard setting landscape. This paper tries to provide a broad and comprehensive picture of informal standards consortia and their dynamic development in the past ten years. Analyses show that consortia have distinct characteristics which help to position and explain their existence in the standard setting context. Furthermore the observation of consortia survival identifies relat...

  10. PrEP (Pre-Exposure Prophylaxis) 101

    Science.gov (United States)

    ... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

  11. High-Tech Architecture

    Directory of Open Access Journals (Sweden)

    Özlem Eşsiz

    1999-05-01

    Full Text Available The technological development in building and construction area, bring with the new construction systems and the new products. The aim of this study is to define the High Tech concept, and set the common and basic characteristics of High Tech applications. During 1970’s High Tech was born and developed in Britain. Especially British Architects Richard Rogers, Michael Hopkins, Norman Foster, Nicholas Grimshaw and Ian Ritchie are the leaders of this style. Their architecture show the machine aesthetic and use of industrial revoluation materials such as glass and steel. The reasons for wide usage of this technology in building constructions are; the ease of renewing the structural and installation systems by the changing technology and giving monumentality to the prestige buildings. High Tech building which we have many examples of give their occupants a lot of opportunities and also they can adapt itself to the time.

  12. HI-TECH OLYMPICS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The only Chinese company in The Olympic Partner Program, Lenovo supplies hi-tech in return for worldwide rights to Olympic logos Nineteen eighty-four was a lucky year for China as the country resumed its seat on the

  13. R&D Consortia: Are They Working?

    Science.gov (United States)

    Dinneen, Gerald P.

    1988-01-01

    Discusses the increasing importance of cooperative or joint R&D, including R&D Consortia, for private sector companies. Cites successful government-sponsored cooperative efforts which have made a difference in how private industry viewed technology and R&D. (RT)

  14. Leveraging Higher Education Consortia for Institutional Advancement

    Science.gov (United States)

    Burley, Diana; Gnam, Cathy; Newman, Robin; Straker, Howard; Babies, Tanika

    2012-01-01

    Purpose: The purpose of this paper is to explore conceptually the role of higher education consortia in facilitating the operational advancement of member institutions, and in enabling their development as learning organizations in a changing and competitive higher education environment. Design/methodology/approach: This article synthesizes the…

  15. Design and construction of synthetic microbial consortia in China

    Directory of Open Access Journals (Sweden)

    Ming-Zhu Ding

    2016-12-01

    Full Text Available The rapid development of synthetic biology enables the design, construction and optimization of synthetic microbial consortia to achieve specific functions. In China, the “973” project-“Design and Construction of Microbial Consortia” was funded by the National Basic Research Program of China in January 2014. It was proposed to address the fundamental challenges in engineering natural microbial consortia and reconstructing microbial consortia to meet industrial demands. In this review, we will introduce this “973” project, including the significance of microbial consortia, the fundamental scientific issues, the recent research progresses, and some case studies about synthetic microbial consortia in the past two and a half years.

  16. High-tech entrepreneurship

    DEFF Research Database (Denmark)

    Bernasconi, Michel; Harris, Simon; Mønsted, Mette

    ; entrepreneurial finance; marketing technological innovations; and high-tech incubation management. Including case studies to give practical insights into genuine business examples, this comprehensive book has a distinctly 'real-world' focus throughout.Edited by a multi-national team, this comprehensive book......High-tech businesses form a crucial part of entrepreneurial activity - in some ways representing very typical examples of entrepreneurship, yet in some ways representing quite different challenges. The uncertainty in innovation and advanced technology makes it difficult to use conventional economic...... planning models, and also means that the management skills used in this area must be more responsive to issues of risk, uncertainty and evaluation than in conventional business opportunities. Whilst entrepreneurial courses do reflect the importance of high-tech businesses, they often lack the resources...

  17. Developing symbiotic consortia for lignocellulosic biofuel production

    Energy Technology Data Exchange (ETDEWEB)

    Zuroff, Trevor R.; Curtis, Wayne R. [Pennsylvania State Univ., University Park, PA (United States). Dept. of Chemical Engineering

    2012-02-15

    The search for petroleum alternatives has motivated intense research into biological breakdown of lignocellulose to produce liquid fuels such as ethanol. Degradation of lignocellulose for biofuel production is a difficult process which is limited by, among other factors, the recalcitrance of lignocellulose and biological toxicity of the products. Consolidated bioprocessing has been suggested as an efficient and economical method of producing low value products from lignocellulose; however, it is not clear whether this would be accomplished more efficiently with a single organism or community of organisms. This review highlights examples of mixtures of microbes in the context of conceptual models for developing symbiotic consortia for biofuel production from lignocellulose. Engineering a symbiosis within consortia is a putative means of improving both process efficiency and stability relative to monoculture. Because microbes often interact and exist attached to surfaces, quorum sensing and biofilm formation are also discussed in terms of consortia development and stability. An engineered, symbiotic culture of multiple organisms may be a means of assembling a novel combination of metabolic capabilities that can efficiently produce biofuel from lignocellulose. (orig.)

  18. Nalco Fuel Tech

    Energy Technology Data Exchange (ETDEWEB)

    Michalak, S.

    1995-12-31

    The Nalco Fuel Tech with its seat at Naperville (near Chicago), Illinois, is an engineering company working in the field of technology and equipment for environmental protection. A major portion of NALCO products constitute chemical materials and additives used in environmental protection technologies (waste-water treatment plants, water treatment, fuel modifiers, etc.). Basing in part on the experience, laboratories and RD potential of the mother company, the Nalco Fuel Tech Company developed and implemented in the power industry a series of technologies aimed at the reduction of environment-polluting products of fuel combustion. The engineering solution of Nalco Fuel Tech belong to a new generation of environmental protection techniques developed in the USA. They consist in actions focused on the sources of pollutants, i.e., in upgrading the combustion chambers of power engineering plants, e.g., boilers or communal and/or industrial waste combustion units. The Nalco Fuel Tech development and research group cooperates with leading US investigation and research institutes.

  19. Tech Gets Physical

    Science.gov (United States)

    Ravage, Barbara

    2011-01-01

    As colleges push for increased efficiencies, facilities departments nationwide are turning more and more to high-tech approaches. Nowhere has this trend been more visible than in the realm of energy consumption, where managers hope to extract significant cost savings. Technology is helping facilities managers achieve significant efficiencies,…

  20. 76 FR 3145 - Pediatric Device Consortia Grant Program (P50)

    Science.gov (United States)

    2011-01-19

    ... just rare diseases. The pediatric population (neonates, infants, children, and adolescents) includes... to nonprofit consortia to promote pediatric device development. B. Research Objectives The goal...

  1. Best Practices in Establishing and Sustaining Consortia in Pharmacy Education.

    Science.gov (United States)

    Danielson, Jennifer; Hincapie, Ana; Baugh, Gina; Rice, Luke; Sy, Erin; Penm, Jonathan; Albano, Christian

    2017-03-25

    Objective. To describe best practices, necessary resources, and success or lessons learned from established consortia in pharmacy education. Methods. Using semi-structured interviews and qualitative analysis, interviews with members of established consortia in pharmacy education were conducted until saturation was reached. Themes were analyzed and meaningful descriptions of consortia characteristics were developed using systematic text condensation. Results. Thirteen interviews were conducted. The primary purpose for forming a consortium was identified as threefold: share ideas/best practices; facilitate collaboration; and perform shared problem-solving. For experiential education consortia, two additional purposes were found: share capacity for practice sites, and promote standardization across programs. When investigating best practices for established consortia, three main themes were identified. These included strategies for: (1) relationship building within consortia, (2) successful outcomes of consortia, and (3) sustainability. Successful outcomes included scholarship and, sometimes, program standardization. Sustainability was linked to structure/support and momentum. Respect was considered the foundation for collaborative relationships to flourish in these consortia. Conclusions. Pharmacy education consortia form through a process that involves relationship building to produce outcomes that promote sustainability, which benefits both pharmacy schools and individual faculty members. Consortium formation is a viable, productive, and often necessary institutional goal for pharmacy schools.

  2. High tech cheating.

    Science.gov (United States)

    Harper, Mary G

    2006-12-01

    The use of technology has enhanced the convenience, flexibility, and efficiency of both preparatory and continuing education. Unfortunately, academic dishonesty, including plagiarism, has shown a positive correlation with the increased use of technology in education. A review of the literature related to unintended outcomes of the use of technology in nursing education and continuing education was conducted to determine the ethical implications for the nursing profession. Although nursing research dealing with academic and professional misconduct is sparse, evidence suggests that academic dishonesty is a predictor of workplace dishonesty. Given this correlation between unethical classroom behavior and unethical clinical behavior, efforts to staunch academic dishonesty may help allay professional misconduct. A combination of high tech and low tech methods may be used to minimize unethical behaviors among students and practicing professional nurses in order to maintain the integrity of the profession.

  3. How To Start a Prep Physics Course

    Science.gov (United States)

    Wall, Jesse D.

    1998-04-01

    At City College, we follow our mother institution, the University of California at Berkeley, in that we require high school physics as a prerequisite for general college physics and then provide a one-semester prep physics course as an alternative to meet this prerequisite. Many people have asked me how they can start such a course. In traveling about on my sabbatical, doing Physics Of Magic (1) at various schools, I have observed how various schools implement this prerequisite course. I will discuss my observations.

  4. Microbial consortia for hydrogen production enhancement.

    Science.gov (United States)

    Rajhi, Haifa; Díaz, Emiliano E; Rojas, Patricia; Sanz, José L

    2013-07-01

    Ten efficient hydrogen-producing strains affiliated to the Clostridium genus were used to develop consortia for hydrogen production. In order to determine their saccharolytic and proteolytic activities, glucose and meat extract were tested as fermentation substrates, and the best hydrogen-producing strains were selected. The C. roseum H5 (glucose-consuming) and C. butyricum R4 (protein-degrading) co-culture was the best hydrogen-producing co-culture. The end-fermentation products for the axenic cultures and co-cultures were analyzed. In all cases, organic acids, mainly butyrate and acetate, were produced lowering the pH and thus inhibiting further hydrogen production. In order to replace the need for reducing agents for the anaerobic growth of clostridia, a microbial consortium including Clostridium spp. and an oxygen-consuming microorganism able to form dense granules (Streptomyces sp.) was created. Increased yields of hydrogen were achieved. The effect of adding a butyrate-degrading bacteria and an acetate-consuming archaea to the consortia was also studied.

  5. Tech-Prep: The School-to-Work Connection in Criminal Justice.

    Science.gov (United States)

    Striegel, David; Gray, Michael

    2000-01-01

    Suggests that community colleges should focus more on academics than on technical skills when preparing students to enter the criminal justice system. Asserts that the technical skills needed by workers in law enforcement can be acquired in the police academy, while crucial critical thinking and writing skills are better taught in the college…

  6. Review of HIV Pre exposure prophylaxis (PrEP) and example of HIV PrEP Toolkit

    Science.gov (United States)

    2017-08-28

    Interventions Aim: to reduce the efficiency of transmission or to shorten the duration of infectiousness Usexual Partners U Sharing Needles Older Age...Program HIV PrEP Portfolio - DoD-wide PrEP experience to date (Beckett, Okulicz, Blaylock/Garges, MHRP/WRAIR*) • Analysis of all DoD beneficiaries

  7. The TechSAT program

    Science.gov (United States)

    Shachar, M.; Lapid, P.

    1992-12-01

    The TechSAT project is described which is intended to establish a wide academic infrastructure for the development of new space technologies. A TechSAT satellite will be used for educational purposes by the academic staff and students as well as by radio amateurs. Tech SAT is a microsatellite weighing 50 kg with 45x45x45 cm dimensions. It is based on a Nadir pointing 3D stabilized platform with body mounted solar panels. The TechSAT hardware includes an autonomous attitude control system, a power supply system, and an onboard computer. Command control and telemetry systems will be based on the amateur radio communications payload.

  8. Potential reduced exposure products (PREPs) in industry trial testimony.

    Science.gov (United States)

    Wayne, Geoffrey Ferris

    2006-12-01

    To identify patterns in trial testimony that may reflect on the intentions or expectations of tobacco manufacturers with regard to the introduction of potential reduced exposure products (PREPs). Research was conducted using the Deposition and Trial Testimony Archive (DATTA) collection of trial testimony and depositions housed online at Tobacco Documents Online (www.tobaccodocuments.org). Relevant testimony was identified through full-text searches of terms indicating PREPs or harm reduction strategies. The role and function of PREPs in testimony were classified according to common and contrasting themes. These were analysed in the context of broader trial arguments and against changes in time period and the market. Analysis of testimony suggests that the failure of PREPs in the market tempered initial industry enthusiasm and made protection of the conventional cigarette market its major priority. The "breakthrough" character of PREPs has been de-emphasised, with trial arguments instead positioning PREPs as simply another choice for consumers. This framework legitimises the sale of conventional brands, and shifts the responsibility for adoption of safer products from the manufacturer to the consumer. Likewise, testimony has abandoned earlier dramatic health claims made with regard to PREPs, which had undermined industry arguments regarding efforts to reduce harm in conventional products. More recent testimony advocates the broad acceptance of independent guidelines that would validate use of health claims and enable the industry to market PREPs to consumers. Trial testimony reflects the changing role and positioning of PREPs by the tobacco industry. The findings are of particular importance with regard to future evaluation and potential regulation of reduced harm products.

  9. Planning a Successful Tech Show

    Science.gov (United States)

    Nikirk, Martin

    2011-01-01

    Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact…

  10. Governance of Transnational Global Health Research Consortia and Health Equity.

    Science.gov (United States)

    Pratt, Bridget; Hyder, Adnan A

    2016-10-01

    Global health research partnerships are increasingly taking the form of consortia of institutions from high-income countries and low- and middle-income countries that undertake programs of research. These partnerships differ from collaborations that carry out single projects in the multiplicity of their goals, scope of their activities, and nature of their management. Although such consortia typically aim to reduce health disparities between and within countries, what is required for them to do so has not been clearly defined. This article takes a conceptual approach to explore how the governance of transnational global health research consortia should be structured to advance health equity. To do so, it applies an account called shared health governance to derive procedural and substantive guidance. A checklist based on this guidance is proposed to assist research consortia determine where their governance practices strongly promote equity and where they may fall short.

  11. Design, construction, and characterization methodologies for synthetic microbial consortia.

    Science.gov (United States)

    Bernstein, Hans C; Carlson, Ross P

    2014-01-01

    Engineered microbial consortia are of growing interest to a range of scientists including bioprocess engineers, systems biologists, and microbiologists because of their ability to simultaneously optimize multiple tasks, to test fundamental systems science, and to understand the microbial ecology of environments like chronic wounds. Metabolic engineering, synthetic biology, and microbial ecology provide a sound scientific basis for designing, building, and analyzing consortium-based microbial platforms.This chapter outlines strategies and protocols useful for (1) in silico network design, (2) experimental strain construction, (3) consortia culturing including biofilm growth methods, and (4) physiological characterization of consortia. The laboratory and computational methods given here may be adapted for synthesis and characterization of other engineered consortia designs.

  12. Metabolic interactions between methanogenic consortia and anaerobic respiring bacteria

    DEFF Research Database (Denmark)

    Stams, A.J.; Oude Elferink, S.J.; Westermann, Peter

    2003-01-01

    Most types of anaerobic respiration are able to outcompete methanogenic consortia for common substrates if the respective electron acceptors are present in sufficient amounts. Furthermore, several products or intermediate compounds formed by anaerobic respiring bacteria are toxic to methanogenic...

  13. Which Move to the Middle: Industry Consortia or Private Exchanges?

    OpenAIRE

    Susan A. Sherer; Yuliang Yao

    2006-01-01

    The move-to-the-middle hypothesis has been used to predict firm structures, suggesting that firms will move to more outsourcing but from a reduced set of stable partners (Clemons et al., 1993). Extending this hypothesis to predict electronic marketplace structures, we suggest that both industry consortia and private exchanges represent a move to the middle by reducing transaction costs and risks. In industries with highly interdependent relationships, industry consortia may be more successful...

  14. Attributes and Dynamic Development Phases of ICT Standards Consortia

    OpenAIRE

    Pohlmann, Tim

    2010-01-01

    Standards consortia are private industry alliances that serve a certain purpose and gather likeminded companies that share the same interest to sponsor and develop technologies for standardization. Compared to formal standard setting, participation in consortia is less bureaucratic, more efficient in reacting to market needs and allows, in respect to the tiered membership structures, a strategic influence of standard setting outcomes. Formal standardization is in contrast an often protracted ...

  15. New Tech, New Ties:

    DEFF Research Database (Denmark)

    Ling, Richard

    regardless of where they are. But when we are engaged in these intimate conversations with absent friends, what happens to our relationship with the people who are actually in the same room with us? In New Tech, New Ties, Rich Ling examines how the mobile telephone affects both kinds of interactions......—those mediated by mobile communication and those that are face to face. Ling finds that through the use of various social rituals the mobile telephone strengthens social ties within the circle of friends and family—sometimes at the expense of interaction with those who are physically present—and creates what he...... calls "bounded solidarity." Ling argues that mobile communication helps to engender and develop social cohesion within the family and the peer group. Drawing on the work of Emile Durkheim, Erving Goffman, and Randall Collins, Ling shows that ritual interaction is a catalyst for the development of social...

  16. Vigor Clean Tech Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Brubacher-Cressman, Dale [Vigor Clean Tech Inc. (Canada)

    2011-07-01

    On May 5, 2011, the Ontario Waterpower Association hosted the emergent hydro workshop in Peterborough. The first technology presented by Vigor Clean Tech Inc. was a system with a vertical axis which is supported by a floating structure and can provide 10's of kWs. The second one is the PowerPipe, an in-conduit system which can be implemented in existing or new conduits and that generates electricity from excess head pressure in rapidly flowing water transmission pipelines; the PowerPipe can be used in low head or incremental sites. With Vigor's technology it is possible to generate renewable energy economically on a small scale and to leverage under-utilized infrastructures. However, to date, few field applications have been carried out. This presentation provided information on a technology which has the potential to produce a steady supply of reliable renewable energy on a small scale.

  17. Tech transfer outreach

    Energy Technology Data Exchange (ETDEWEB)

    Liebetrau, S. (ed.)

    1992-01-01

    This document provides an informal summary of the conference workshop sessions. Tech Transfer Outreach '' was originally designed as an opportunity for national laboratory communications and technology transfer staff to become better acquainted and to discuss matters of mutual interest. When DOE field office personnel asked if they could attend, and then when one of our keynote speakers became a participant in the discussions, the actual event grew in importance. The conference participants--the laboratories and DOE representatives from across the nation--worked to brainstorm ideas. Their objective: identify ways to cooperate for effective (and cost-effective) technology transfer outreach. Thus, this proceedings is truly a product of ten national laboratories and DOE, working together. It candidly presents the discussion of issues and the ideas generated by each working group. The issues and recommendations are a consensus of their views.

  18. PrEP implementation research in Africa: what is new?

    Directory of Open Access Journals (Sweden)

    Frances M Cowan

    2016-10-01

    Full Text Available Introduction: Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM, transgender women and injection drug users are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion: In each of the target populations, there are overarching issues related to (i creating demand for PrEP, (ii addressing supply-side issues and (iii providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely

  19. AirfoilPrep.py Documentation: Release 0.1.0

    Energy Technology Data Exchange (ETDEWEB)

    Ning, S. A. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-09-01

    AirfoilPrep.py provides functionality to preprocess aerodynamic airfoil data. Essentially, the module is an object oriented version of the AirfoilPrep spreadsheet with additional functionality and is written in the Python language. It allows the user to read in two-dimensional aerodynamic airfoil data, apply three-dimensional rotation corrections for wind turbine applications, and extend the datato very large angles of attack. This document discusses installation, usage, and documentation of the module.

  20. High Tech M&As

    DEFF Research Database (Denmark)

    Toppenberg, Gustav

    2013-01-01

    of findings are not applicable to the high-tech industry; in fact this industry has many additional challenges. In this study, we aim to explore the process of M&A in the high-tech industry by drawing on extant literature and empirical field work. The paper outlines a research project in progress which...... intends to provide theoretical, empirical and practical contributions in answering the research question: what role does Operations and IT play in creating value in high-tech M&As? The research adds a needed perspective on M&A literature by unveiling unique challenges and opportunities faced by the M...

  1. TechEdSat Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of the Technical Education Satellite (TechEdSat) is to employ a small spacecraft to evaluate, demonstrate, and validate two new technologies for...

  2. Microbial consortia in meat processing environments

    Science.gov (United States)

    Alessandria, V.; Rantsiou, K.; Cavallero, M. C.; Riva, S.; Cocolin, L.

    2017-09-01

    Microbial contamination in food processing plants can play a fundamental role in food quality and safety. The description of the microbial consortia in the meat processing environment is important since it is a first step in understanding possible routes of product contamination. Furthermore, it may contribute in the development of sanitation programs for effective pathogen removal. The purpose of this study was to characterize the type of microbiota in the environment of meat processing plants: the microbiota of three different meat plants was studied by both traditional and molecular methods (PCR-DGGE) in two different periods. Different levels of contamination emerged between the three plants as well as between the two sampling periods. Conventional methods of killing free-living bacteria through antimicrobial agents and disinfection are often ineffective against bacteria within a biofilm. The use of gas-discharge plasmas potentially can offer a good alternative to conventional sterilization methods. The purpose of this study was to measure the effectiveness of Atmospheric Pressure Plasma (APP) surface treatments against bacteria in biofilms. Biofilms produced by three different L. monocytogenes strains on stainless steel surface were subjected to three different conditions (power, exposure time) of APP. Our results showed how most of the culturable cells are inactivated after the Plasma exposure but the RNA analysis by qPCR highlighted the entrance of the cells in the viable-but non culturable (VBNC) state, confirming the hypothesis that cells are damaged after plasma treatment, but in a first step, still remain alive. The understanding of the effects of APP on the L. monocytogenes biofilm can improve the development of sanitation programs with the use of APP for effective pathogen removal.

  3. PREP advertisement features affect smokers' beliefs regarding potential harm.

    Science.gov (United States)

    Strasser, A A; Tang, K Z; Tuller, M D; Cappella, J N

    2008-09-01

    The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. To determine the effect of altering advertisement features on smokers' beliefs of the harm exposure from a PREP. A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a "red" condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a "no text" condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using "incorrect," "unsure" and "correct" as outcomes, and advertisement type and covariates as predictors, was used for analyses. Participants randomised to the "no text" advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, are healthier and make smoking safer. Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising.

  4. NEXT GENERATION ORAL PrEP: BEYOND TENOFOVIR

    Science.gov (United States)

    Abraham, Bisrat K.; Gulick, Roy

    2013-01-01

    Purpose Clinical trials of oral pre-exposure prophylaxis (PrEP) have focused testing on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone) and FTC may select for drug resistance. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV prevention. Recent Findings Several drug characteristics are important to consider when selecting agents for PrEP with the most critical being safety, tolerability, adequate penetration into target tissues, prevention of HIV infection, and long lasting activity with convenient dosing. With these factors in mind, we review several potentially useful agents for PrEP. The first group includes drugs that are already FDA-approved (maraviroc, raltegravir) with attributes that make them attractive for PrEP. The second groups of drugs include investigational agents with long-lasting activities that are being developed in parenteral form (rilpivirine-long acting, S/GSK 1265744, ibalizumab). Summary Current research suggests there will be a broader array of PrEP drugs to choose from in the near future, thereby giving clinicians the flexibility to select agents that best suit the needs of their patient population. PMID:23032733

  5. Partner Power: A study of two distance education consortia

    Directory of Open Access Journals (Sweden)

    Anne Banks Pidduck

    2006-12-01

    Full Text Available This research reports findings from a study which explored the process and criteria of partner selection – how and why partners are chosen – for two distance education consortia. The researchers reviewed recent literature on partnerships and partner selection. Two Canada-wide distance education consortia were identified as large-scale case studies for investigation of the research theory. A total of 34 informants were contacted. Written business plans, contracts, documents, partner network diagrams, and 231 archival emails from 36 correspondents were collected and analyzed for the two consortia. The research identified four criteria that influence why specific partners are chosen: requirements, resource availability, social network, and reputation. These findings suggest that the formation of partnerships and the process of partner selection are both very complex.

  6. The value of research collaborations and consortia in rare cancers.

    Science.gov (United States)

    Blay, Jean-Yves; Coindre, Jean-Michel; Ducimetière, Françoise; Ray-Coquard, Isabelle

    2016-02-01

    Rare cancers are defined by an incidence of less than six per 100,000 people per year. They represent roughly 20% of all human cancers and are associated with worse survival than are so-called frequent tumours, because of delays to accurate diagnosis, inadequate treatments, and fewer opportunities to participate in clinical trials (because of a paucity of dedicated trials from both academic and industrial sponsors). In this Series paper, we discuss how these challenges can be addressed by research consortia and suggest the integration of these consortia with reference networks, which gather multidisciplinary expert centres, for management of rare tumours.

  7. Assessing organizational effectiveness in higher education drug prevention consortia.

    Science.gov (United States)

    Sheldon-Keller, A E; Lloyd-McGarvey, E; Canterbury, R J

    1995-01-01

    Eighty-three consortia of institutions of higher education, organized under funding from the Fund for the Improvement of Post-Secondary Education (FIPSE) Drug Prevention Programs of the Department of Education, were surveyed to measure organizational effectiveness. Generalized satisfaction with the functioning of the consortia was related to the number of active members, the average miles traveled to meetings, satisfaction with performance of task functions, members' roles, the level of trust among members and the level of creativity and innovation in problem-solving. Satisfaction with goal attainment was significantly related to the presence of at least one "internal" goal for the consortium.

  8. New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA

    Science.gov (United States)

    Zucchelli, Chiara; Ferrari, Elena; Blasi, Francesco; Musco, Giovanna; Bruckmann, Chiara

    2017-01-01

    PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA binding. The kinetic parameters for DNA binding of individual PREP1 and PBX1 HDs, and of their combination, show that isolated PREP1 and PBX1 HDs bind to DNA in a cooperative manner. A novel PREP1 motif, flanking the HD at the C-terminus, is required for cooperativity. PMID:28094776

  9. Partnering with Sandia National Laboratories through alliances or consortia

    Energy Technology Data Exchange (ETDEWEB)

    Winchell, B.M.

    1994-12-01

    To better facilitate working with industry, groups of industrial participants, and partners in alliances or consortia, Sandia National Laboratories presents information helpful to those outside groups as to the forms of arrangements that may be used to better facilitate partnering relationships between Sandia National Laboratories and consortia or alliances of outside parties. It is expected that these alliances and consortia will include both large and small for-profit industrial concerns, as well as not-for-profit entities such as universities, institutes, other research facilities, and other nonprofit institutions or consortia containing institutions. The intent of this report is to provide such outside groups with information that will facilitate rapid interactions with Sandia National Laboratories through some of these forms of business which will be discussed in this report. These are not the only approaches to facilitating business interactions with Sandia National Laboratories and it is not intended that this report be legal advice or required approaches to doing business with Sandia National Laboratories. The intent of this report is merely to suggest ways in which Sandia National Laboratories can work with outside parties in the most expeditious manner.

  10. Library networks and consortia in Mexico country report

    OpenAIRE

    Mattes, Daniel; Lugo Hubp, Margarita

    2004-01-01

    The authors present the library networks and consortia in Mexico country. The most important characteristics are the following: Scarce library cooperation in general, insufficient budget, especially in public institutions, noteworthy efforts identified in small library groups and some progress made in the last decade.

  11. Partnering with Sandia National Laboratories through alliances or consortia

    Energy Technology Data Exchange (ETDEWEB)

    Winchell, B.M.

    1994-04-01

    To better facilitate working with industry, groups of industrial participants, and partners in alliances or consortia, Sandia National laboratories presents information helpful to those outside groups as to the forms of arrangements that may be used to better facilitate partnering relationships between Sandia National Laboratories and consortia or alliances of outside parties. It is expected that these alliances and consortia will include both large and small for-profit industrial concerns, as well as not-for-profit entities such as universities, institutes, other research facilities, and other nonprofit institutions or consortia containing institutions. The intent of this report is to provide such outside groups with information that will facilitate rapid interactions with Sandia National Laboratories through some of these forms of business which will be discussed in this report. These are not the only approaches to facilitating business interactions with Sandia National Laboratories and it is not intended that this report be legal advice or required approaches to doing business with Sandia National Laboratories. The intent of this report is merely to suggest ways in which Sandia National Laboratories can work with outside parties in the most expeditious manner.

  12. CROPS : high tech agricultural robots

    NARCIS (Netherlands)

    Bontsema, J.; Hemming, J.; Pekkeriet, E.J.

    2014-01-01

    In the EU-funded CROPS (Clever Robots for Crops) project high tech robots are developed for site-specific spraying and selective harvesting of fruit and fruit vegetables. The harvesting robots are being designed to harvest high-value crops such as greenhouse vegetables, fruits in orchards and grapes

  13. Mentoring clinical ladder advancement with a facilitated prep class.

    Science.gov (United States)

    Winslow, Susan A; Blankenship, Jean

    2007-01-01

    The authors describe a strategy for encouraging participation and overcoming reluctance of staff to participate in an optional professional advancement career ladder program. A facilitated prep class in a computer skills laboratory provides nurses with the framework for completing application requirements in a casual, supportive atmosphere.

  14. SPC-Prep. Instructor's Guide. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This instructor's guide contains materials for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform SPC…

  15. SPC-Prep 1. Participant's Manual. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This companion document to the instructor's guide for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform…

  16. PREP advertisement features affect smokers’ beliefs regarding potential harm

    Science.gov (United States)

    Strasser, Andrew A; Tang, Kathy Z; Tuller, Michael D; Cappella, Joseph N

    2014-01-01

    Background The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. Objective To determine the effect of altering advertisement features on smokers’ beliefs of the harm exposure from a PREP. Methods A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a “red” condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a “no text” condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using “incorrect,” “unsure” and “correct” as outcomes, and advertisement type and covariates as predictors, was used for analyses. Results Participants randomised to the “no text” advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, healthier and make smoking safer. Conclusions Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising. PMID:18768457

  17. Knowledge is Power! Increased Provider Knowledge Scores Regarding Pre-exposure Prophylaxis (PrEP) are Associated with Higher Rates of PrEP Prescription and Future Intent to Prescribe PrEP.

    Science.gov (United States)

    Blumenthal, Jill; Jain, Sonia; Krakower, Douglas; Sun, Xiaoying; Young, Jason; Mayer, Kenneth; Haubrich, Richard

    2015-05-01

    The FDA approval of emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP) in 2012 has raised questions about the delivery of PrEP in a real-world setting. iPad-based questionnaires were given to providers at conferences in California and New York to assess knowledge, experience and attitudes regarding PrEP in HIV and non-HIV providers. HIV provider status was defined either by self-identification or by having greater than 5 years of HIV care experience. Knowledge scores were the sum of correct answers from five PrEP knowledge questions. Univariate analyses used t-test to compare knowledge scores and Fisher's exact test for past or future PrEP prescription between HIV and non-HIV providers. Multivariable linear or logistic regression models were used to assess factors associated with the outcomes. Of 233 respondents, the mean age was 40 years, 59 % were White, 59 % were physicians and 52 % were HIV providers. In univariate analysis, mean PrEP knowledge scores (max 5) were significantly higher for HIV providers (2.8 versus 2.2; p 41 (mean 2.8 versus 2.3; p = 0.004), White race (2.7 versus 2.2; p = 0.026) and participants in the New York region (3.0 versus 2.3; p knowledge scores, all but age remained significant. Among 201 potential prescribers, the rate of prior PrEP prescription was higher among HIV providers than non-HIV providers (34 versus 9 %; p knowledge score, but the association with provider status was no longer significant in multivariable analysis that controlled for knowledge. Intent to prescribe PrEP in the future was high for all provider types (64 %) and was associated with knowledge scores in multivariable analysis. The most common concerns about PrEP (>40 % of providers) were drug toxicities, development of resistance and patient adherence to follow-up; 32 % identified risk compensation as a concern. HIV providers had significantly greater PrEP knowledge than non-HIV providers, but differences by provider type in past PrEP

  18. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    Science.gov (United States)

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  19. PrEP in Europe – expectations, opportunities and barriers

    Science.gov (United States)

    McCormack, Sheena Mary; Noseda, Veronica; Molina, Jean-Michel

    2016-01-01

    Introduction In contrast to the global trend showing a decline in new HIV infections, the number reported in the World Health Organization (WHO) region of Europe is increasing. Health systems are disparate, but even countries with free access to screening and treatment observe continuing high rates of new infections in key populations, notably men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is only available in France. This commentary describes the European epidemics and healthcare settings where PrEP could be delivered, how need might be estimated for MSM and the residual barriers to access. Discussion Health systems and government commitment to HIV prevention and care, both financial and political, differ considerably between the countries that make up Europe. A common feature is that funds for prevention are a small fraction of funds for care. Although care is generally good, access is limited in the middle-income countries of Eastern Europe and central Asia, and only 19% of people living with HIV received antiretroviral therapy in 2014. It is challenging to motivate governments or civil society to implement PrEP in the context of this unmet treatment need, which is driven by limited national health budgets and diminishing assistance from foreign aid. The high-income countries of Western Europe have hesitated to embrace PrEP for different reasons, initially due to key gaps in the evidence. Now that PrEP has been shown to be highly effective in European MSM in two randomized controlled trials, it is clear that the major barrier is the cost of the drug which is still on patent, although inadequate health systems and diminishing investment in civil society are also key challenges to overcome. Conclusions The momentum to implement PrEP in European countries is increasing and provides a welcome opportunity to expand and improve clinical services and civil society support focused on HIV and related infections including other sexually transmitted and

  20. Instructional and Organizational Effectiveness in Selected PREPS-Identified Value Added and PREPS-Identified Value Subtracted Elementary Schools in Mississippi

    Science.gov (United States)

    Henderson, Jimmy Dale

    2011-01-01

    This study examined the perceptions of principals, teachers, and support staff at 3 PREPS-identified value added and three PREPS-identified value subtracted elementary schools in Mississippi to determine if there were "effective schools" practices in the areas of instructional and organizational systems that were unique to either group. The…

  1. Development of autochthonous microbial consortia for enhanced phytoremediation of salt-marsh sediments contaminated with cadmium.

    Science.gov (United States)

    Teixeira, Catarina; Almeida, C Marisa R; Nunes da Silva, Marta; Bordalo, Adriano A; Mucha, Ana P

    2014-09-15

    Microbial assisted phytoremediation is a promising, though yet poorly explored, new remediation technique. The aim of this study was to develop autochthonous microbial consortia resistant to cadmium that could enhance phytoremediation of salt-marsh sediments contaminated with this metal. The microbial consortia were selectively enriched from rhizosediments colonized by Juncus maritimus and Phragmites australis. The obtained consortia presented similar microbial abundance but a fairly different community structure, showing that the microbial community was a function of the sediment from which the consortia were enriched. The effect of the bioaugmentation with the developed consortia on cadmium uptake, and the microbial community structure associated to the different sediments were assessed using a microcosm experiment. Our results showed that the addition of the cadmium resistant microbial consortia increased J. maritimus metal phytostabilization capacity. On the other hand, in P. australis, microbial consortia amendment promoted metal phytoextraction. The addition of the consortia did not alter the bacterial structure present in the sediments at the end of the experiments. This study provides new evidences that the development of autochthonous microbial consortia for enhanced phytoremediation of salt-marsh sediments contaminated with cadmium might be a simple, efficient, and environmental friendly remediation procedure. Development of autochthonous microbial consortia resistant to cadmium that enhanced phytoremediation by salt-marsh plants, without a long term effect on sediment bacterial diversity. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Development of autochthonous microbial consortia for enhanced phytoremediation of salt-marsh sediments contaminated with cadmium

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Catarina [Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas, 289, 4050-123 Porto (Portugal); Laboratório de Hidrobiologia e Ecologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto (Portugal); Almeida, C. Marisa R.; Nunes da Silva, Marta [Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas, 289, 4050-123 Porto (Portugal); Bordalo, Adriano A. [Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas, 289, 4050-123 Porto (Portugal); Laboratório de Hidrobiologia e Ecologia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto (Portugal); Mucha, Ana P., E-mail: amucha@ciimar.up.pt [Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas, 289, 4050-123 Porto (Portugal)

    2014-09-15

    Microbial assisted phytoremediation is a promising, though yet poorly explored, new remediation technique. The aim of this study was to develop autochthonous microbial consortia resistant to cadmium that could enhance phytoremediation of salt-marsh sediments contaminated with this metal. The microbial consortia were selectively enriched from rhizosediments colonized by Juncus maritimus and Phragmites australis. The obtained consortia presented similar microbial abundance but a fairly different community structure, showing that the microbial community was a function of the sediment from which the consortia were enriched. The effect of the bioaugmentation with the developed consortia on cadmium uptake, and the microbial community structure associated to the different sediments were assessed using a microcosm experiment. Our results showed that the addition of the cadmium resistant microbial consortia increased J. maritimus metal phytostabilization capacity. On the other hand, in P. australis, microbial consortia amendment promoted metal phytoextraction. The addition of the consortia did not alter the bacterial structure present in the sediments at the end of the experiments. This study provides new evidences that the development of autochthonous microbial consortia for enhanced phytoremediation of salt-marsh sediments contaminated with cadmium might be a simple, efficient, and environmental friendly remediation procedure. Capsule abstract: Development of autochthonous microbial consortia resistant to cadmium that enhanced phytoremediation by salt-marsh plants, without a long term effect on sediment bacterial diversity. - Highlights: • Cd resistant microbial consortia were developed and applied to salt-marsh sediments. • In Phragmites australis the consortia amendment promoted metal phytoextraction. • The consortia addition increased Juncus maritimus phytostabilization capacity. • No long term changes on the rhizosediment bacterial structure were observed.

  3. Different cultivation methods to acclimatise ammonia-tolerant methanogenic consortia

    DEFF Research Database (Denmark)

    Tian, Hailin; Fotidis, Ioannis; Mancini, Enrico

    2017-01-01

    Bioaugmentation with ammonia tolerant-methanogenic consortia was proposed as a solution to overcome ammonia inhibition during anaerobic digestion process recently. However, appropriate technology to generate ammonia tolerant methanogenic consortia is still lacking. In this study, three basic...... reactors (i.e. batch, fed-batch and continuous stirred-tank reactors (CSTR)) operated at mesophilic (37°C) and thermophilic (55°C) conditions were assessed, based on methane production efficiency, incubation time, TAN/FAN (total ammonium nitrogen/free ammonia nitrogen) levels and maximum methanogenic....... Meanwhile, CSTR reactors were inhibited at lower ammonia levels. Finally, specific methanogenic activity test showed that hydrogenotrophic methanogens were more active than aceticlastic methanogens in all FAN levels above 540 mg NH3-N L-1....

  4. Biomass and Neutral Lipid Production in Geothermal Microalgal Consortia

    Directory of Open Access Journals (Sweden)

    Kathryn Faye Bywaters

    2015-02-01

    Full Text Available Recently, technologies have been developed that offer the possibility of using algal biomass as feedstocks to energy producing systems- in addition to oil-derived fuels (Bird et al., 2011;Bird et al., 2012. Growing native mixed microalgal consortia for biomass in association with geothermal resources has the potential to mitigate negative impacts of seasonally low temperatures on biomass production systems as well as mitigate some of the challenges associated with growing unialgal strains. We assessed community composition, growth rates, biomass and neutral lipid production of microalgal consortia obtained from geothermal hot springs in the Great Basin/Nevada area that were cultured under different thermal and light conditions. Biomass production rates ranged from 368 to 3246 mg C L-1 d-1. The neutral lipid production in these consortia with and without shifts to lower temperatures and additions of bicarbonate (both environmental parameters that have been shown to enhance neutral lipid production ranged from zero to 38.74 mg free fatty acids and triacylglycerols L-1 d-1, the upper value was approximately 6% of the biomass produced. The higher lipid values were most likely due to the presence of Achnanthidium sp. Palmitic and stearic acids were the dominant free fatty acids. The S/U ratio (the saturated to unsaturated FA ratio decreased for cultures shifted from their original temperature to 15°C. Biomass production was within the upper limits of those reported for individual strains, and production of neutral lipids was increased with secondary treatment – all results demonstrate a potential of culturing and manipulating resultant microalgal consortia for biomass-based energy production and perhaps even for biofuels.

  5. Biomass and neutral lipid production in geothermal microalgal consortia.

    Science.gov (United States)

    Bywaters, Kathryn F; Fritsen, Christian H

    2014-01-01

    Recently, technologies have been developed that offer the possibility of using algal biomass as feedstocks to energy producing systems - in addition to oil-derived fuels (Bird et al., 2011, 2012). Growing native mixed microalgal consortia for biomass in association with geothermal resources has the potential to mitigate negative impacts of seasonally low temperatures on biomass production systems as well as mitigate some of the challenges associated with growing unialgal strains. We assessed community composition, growth rates, biomass, and neutral lipid production of microalgal consortia obtained from geothermal hot springs in the Great Basin/Nevada area that were cultured under different thermal and light conditions. Biomass production rates ranged from 39.0 to 344.1 mg C L(-1) day(-1). The neutral lipid production in these consortia with and without shifts to lower temperatures and additions of bicarbonate (both environmental parameters that have been shown to enhance neutral lipid production) ranged from 0 to 38.74 mg free fatty acids (FFA) and triacylglycerols (TAG) L(-1 )day(-1); the upper value was approximately 6% of the biomass produced. The higher lipid values were most likely due to the presence of Achnanthidium sp. Palmitic and stearic acids were the dominant free fatty acids. The S/U ratio (the saturated to unsaturated FA ratio) decreased for cultures shifted from their original temperature to 15°C. Biomass production was within the upper limits of those reported for individual strains, and production of neutral lipids was increased with secondary treatment. All results demonstrate a potential of culturing and manipulating resultant microalgal consortia for biomass-based energy production and perhaps even for biofuels.

  6. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Directory of Open Access Journals (Sweden)

    Iryna Zablotska

    2016-10-01

    Full Text Available Introduction: HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM and other key populations. Pre-exposure prophylaxis (PrEP is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion: Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions: Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes.

  7. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Science.gov (United States)

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  8. Consortia of cyanobacteria/microalgae and bacteria: biotechnological potential.

    Science.gov (United States)

    Subashchandrabose, Suresh R; Ramakrishnan, Balasubramanian; Megharaj, Mallavarapu; Venkateswarlu, Kadiyala; Naidu, Ravi

    2011-01-01

    Microbial metabolites are of huge biotechnological potential and their production can be coupled with detoxification of environmental pollutants and wastewater treatment mediated by the versatile microorganisms. The consortia of cyanobacteria/microalgae and bacteria can be efficient in detoxification of organic and inorganic pollutants, and removal of nutrients from wastewaters, compared to the individual microorganisms. Cyanobacterial/algal photosynthesis provides oxygen, a key electron acceptor to the pollutant-degrading heterotrophic bacteria. In turn, bacteria support photoautotrophic growth of the partners by providing carbon dioxide and other stimulatory means. Competition for resources and cooperation for pollutant abatement between these two guilds of microorganisms will determine the success of consortium engineering while harnessing the biotechnological potential of the partners. Relative to the introduction of gene(s) in a single organism wherein the genes depend on the regulatory- and metabolic network for proper expression, microbial consortium engineering is easier and achievable. The currently available biotechnological tools such as metabolic profiling and functional genomics can aid in the consortium engineering. The present review examines the current status of research on the consortia, and emphasizes the construction of consortia with desired partners to serve a dual mission of pollutant removal and commercial production of microbial metabolites. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Rethinking quasispecies theory: From fittest type to cooperative consortia.

    Science.gov (United States)

    Villarreal, Luis P; Witzany, Guenther

    2013-11-26

    Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops (not individuals) are the basic players. We thus redefine quasispecies as RNA quasispecies consortia (qs-c) and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology. We propose that qs-c is an especially innovative force. We apply qs-c thinking to RNA stem-loops and evaluate how it yields altered bulges and loops in the stem-loop regions, not as errors, but as a natural capability to generate diversity. This basic competence-not error-opens a variety of combinatorial possibilities which may alter and create new biological interactions, identities and newly emerged self identity (immunity) functions. Thus RNA stem-loops typically operate as cooperative modules, like members of social groups. From such qs-c of stem-loop groups we can trace a variety of RNA secondary structures such as ribozymes, viroids, viruses, mobile genetic elements as abundant infection derived agents that provide the stem-loop societies of small and long non-coding RNAs.

  10. Rethinking quasispecies theory: From fittest type to cooperative consortia

    Institute of Scientific and Technical Information of China (English)

    Luis; P; Villarreal; Guenther; Witzany

    2013-01-01

    Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops(not individuals) are the basic players. We thus redefine quasispecies as RNA quasispecies consortia(qs-c) and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology. We propose that qs-c is an especially innovative force. We apply qs-c thinking to RNA stem-loops and evaluate how it yields altered bulges and loops in the stem-loop regions, not as errors, but as a natural capability to generate diversity. This basic competencenot error-opens a variety of combinatorial possibilities which may alter and create new biological interactions, identities and newly emerged self identity(immunity) functions. Thus RNA stem-loops typically operate as cooperative modules, like members of social groups. Fromsuch qs-c of stem-loop groups we can trace a variety of RNA secondary structures such as ribozymes, viroids, viruses, mobile genetic elements as abundant infection derived agents that provide the stem-loop societies of small and long non-coding RNAs.

  11. Polishing of municipal secondary effluent using native microalgae consortia.

    Science.gov (United States)

    Beltrán-Rocha, Julio César; Barceló-Quintal, Icela Dagmar; García-Martínez, Magdalena; Osornio-Berthet, Luis; Saavedra-Villarreal, Nidia; Villarreal-Chiu, Juan; López-Chuken, Ulrico Javier

    2017-04-01

    This work evaluates the use of native microalgae consortia for a dual role: polishing treatment of municipal wastewater effluents and microalgae biomass feedstock potential for biodiesel or biofertilizer production. An initial screening was undertaken to test N and P removal from secondary effluents and biomass production by 12 consortia. A subsequent treatment was performed by selected consortia (01 and 12) under three operational conditions: stirring (S), S + 12 h of daily aeration (S + A) and S + A enriched with CO2 (S + AC). All treatments resulted in compliance with environmental regulations (e.g. Directive 91/271/EEC) and high removal efficiency of nutrients: 64-79% and 80-94% of total N and PO4(3-)-P respectively. During the experiments it was shown that pH alkalinization due to microalgae growth benefits the chemical removal of ammonia and phosphorus. Moreover, advantages of pH increase could be accomplished by intermittent CO2 addition which in this research (treatment S + AC) promoted higher yield and lipid concentration. The resulting dry biomass analysis showed a low lipid content (0.5-4.3%) not ideal for biodiesel production. Moreover, the high rate of ash (29.3-53.0%) suggests that biomass could be readily recycled as a biofertilizer due to mineral supply and organic constituents formed by C, N and P (e.g. carbohydrate, protein, and lipids).

  12. Time-Dependent Effect of Chlorhexidine Surgical Prep

    Science.gov (United States)

    2011-10-15

    skin prep prior to venous puncture for blood cultures has resulted in a lower false-positive ratewhen compared to non-alcoholic povidoneeiodine.9...vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792e801. 9. Caldeira D, David C, Sampaio C. Skin antiseptics in venous puncture -site...load throughout the entire duration of the study. Regarding skin preparation prior to insertion of central venous pressure catheters, the current

  13. Meaning-making in the industrialized test prep classroom

    OpenAIRE

    2011-01-01

    Evidence for the efficacy of test-mimicking pedagogical practices anchored to "non-controversial topics" - what one researcher has referred to as the "McDonaldisation of English" and another, the "TOEFLizing of teaching" - is scarce. Though complex, the crux of the problem is 'negative washback' (the subordination of teaching to the dictates of the international proficiency assessment market) and 'test score pollution' (inflated prep-induced test results). This paper explores the issue in sev...

  14. Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

    Science.gov (United States)

    2015-10-01

    associated sepsis remains the principal lethal risk associated with platelet transfusion. Cold storage (4°C) is known to reduce post transfusion...and no residual radiation is detectable . *P-selectin samples will be prepped on end of storage day and batch tested. **Bacterial Culture sample...temperature controlled room until such time as they have no detectable residual radiation. This is generally about 3-4 months. At that point they are

  15. Development of algae-bacteria granular consortia in photo-sequencing batch reactor.

    Science.gov (United States)

    Liu, Lin; Fan, Hongyong; Liu, Yuhong; Liu, Chaoxiang; Huang, Xu

    2017-05-01

    The development and properties of algae-bacteria granular consortia, which cultivated with the algae (Chlorella and Scenedesmus) and aerobic granules, was investigated in this experiment. The results indicated that the granular consortia could be successfully developed by selection pressure control, and the algal biomass and extracellular polymeric substances (EPS) concentration in the consortia showed notable correlation with the operating parameters of reactor. The maximum specific removal rates of total nitrogen and phosphate were obtained from the granular consortia with the highest algal biomass, yet the correlation between the fatty acid methyl esters yield and the algal biomass in the consortia was not markedly observed. The seed algae maintained dominance in the phototroph community, whereas the cyanobacteria only occupied a small proportion (5.2-6.5%). Although the bacterial communities with different operational strategies showed significant difference, the dominated bacteria (Comamonadaceae, 18.79-36.25%) in the mature granular consortia were similar.

  16. Running-gear Tech 2001; Fahrwerk-Tech 2001. Tagung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Dynamic driving characteristics, active safety and high comfort are conflicting goals which can be combined by active vehicle management systems. The conference discussed modern tools and methods in the fields of design, simulation and experiment. [German] Im Zielkonflikt zwischen Fahrdynamik, aktiver Sicherheit und Komfort bieten Fahrzeugregelsysteme enorme Moeglichkeiten. Systeme fuer Bremsen, Stabilisierung, Daempfung, Aufbaukontrolle und Fahrerassistenz werden in der Zukunft zu einem Fahrwerksmanagement verschmelzen. Diese Fahrzeugintelligenz erfordert moderne Tools und Methoden im Bereich Konzeption, Simulation und Versuch. Die Tagung Fahrwerk-Tech 2001 wird das Fahrwerk in dieser Gesamtheit betrachten und Experten aus den verschiedenen Bereichen zusammen bringen. (orig.)

  17. Allergic contact dermatitis to gamma-irradiated WEBCOL alcohol prep pads.

    Science.gov (United States)

    Firoz, Elnaz F; Turnbull, Rowena K; Loomis, Cynthia A; Brownell, Isaac

    2013-01-01

    We report a case of allergic contact dermatitis to WEBCOL(®) alcohol prep pads in a healthy 17-year-old girl who showed no reaction to the individual components of the prep pads upon provocative use testing. Although several case reports have described allergic contact dermatitis to isopropyl alcohol, there have been no reports of allergic contact dermatitis to alcohol prep pads sterilized with gamma irradiation, a common sterilization technique capable of producing volatile products in this type of alcohol prep pad.

  18. High-tech meets end-user

    NARCIS (Netherlands)

    Steen, M.

    2008-01-01

    One challenge within the high-tech sector is to develop products that end users will actually need and will be able to use. One way of trying to match the design of high-tech products to the needs of end users, is to let researchers and designers interact with them via a human-centred design (HCD) a

  19. Bacterial consortia constructed for the decomposition of Agave biomass

    Science.gov (United States)

    Maki, Miranda; Iskhakova, Svetlana; Zhang, Tingzhou; Qin, Wensheng

    2014-01-01

    Research has shown that a greater variety of enzymes, as well as variety of microorganisms producing enzymes, can have an overall synergistic effect on the decomposition of lignocellulosic biomass for the production of value-added bio-products. Here, 8 cellulase-degrading bacterial isolates were selected to develop co-, tri-, and tetra-cultures for the decomposition of lignocellulosic biomass. Glucose and xylose equivalents released from imitation biomass media containing 0.5% (w/v) beechwood xylan and 0.5% (w/v) Avicel was measured using di-nitrosalicylic acid for all consortia, along with cell growth and survival. Thereafter, 6 co- and 2 tri-cultures with greatest decomposition were examined for ability to degrade Agave americana fiber. Interestingly, when strains were paired up in co-culture, four pairs: G+5, G+A, C+A1, and G+A1 produced high reducing sugars in 24 h: 6 µM, 8 µM, 8 µM, and finally, 6 µM, respectively. From 4 co-cultures with highest reducing sugar equivalents, tri- and tetra-cultures were produced. The bacterial consortia which had the highest reducing sugars detected were 2 tri-cultures: G + A1 + A4 and G + A1 + 5, displaying levels as high as 9 µM and 5 µM in day 1, respectively. All co- and tri-cultures maintained high cell survival for 14 days with 0.5 g ground Agave. Upon evaluating Agave dry weight after treatment, it was evident that almost half the biomass could be decomposed in 14 days. Scanning electron microscopy of treated Agave supported decomposition when compared with the control. These bacterial consortia have potential for further study of value-added by-product production during metabolism of lignocellulosic biomasses. PMID:24637707

  20. Bacterial consortia constructed for the decomposition of Agave biomass.

    Science.gov (United States)

    Maki, Miranda; Iskhakova, Svetlana; Zhang, Tingzhou; Qin, Wensheng

    2014-01-01

    Research has shown that a greater variety of enzymes, as well as variety of microorganisms producing enzymes, can have an overall synergistic effect on the decomposition of lignocellulosic biomass for the production of value-added bio-products. Here, 8 cellulase-degrading bacterial isolates were selected to develop co-, tri-, and tetra-cultures for the decomposition of lignocellulosic biomass. Glucose and xylose equivalents released from imitation biomass media containing 0.5% (w/v) beechwood xylan and 0.5% (w/v) Avicel was measured using di-nitrosalicylic acid for all consortia, along with cell growth and survival. Thereafter, 6 co- and 2 tri-cultures with greatest decomposition were examined for ability to degrade Agave americana fiber. Interestingly, when strains were paired up in co-culture, four pairs: G+5, G+A, C+A1, and G+A1 produced high reducing sugars in 24 h: 6 µM, 8 µM, 8 µM, and finally, 6 µM, respectively. From 4 co-cultures with highest reducing sugar equivalents, tri- and tetra-cultures were produced. The bacterial consortia which had the highest reducing sugars detected were 2 tri-cultures: G + A1 + A4 and G + A1 + 5, displaying levels as high as 9 µM and 5 µM in day 1, respectively. All co- and tri-cultures maintained high cell survival for 14 days with 0.5 g ground Agave. Upon evaluating Agave dry weight after treatment, it was evident that almost half the biomass could be decomposed in 14 days. Scanning electron microscopy of treated Agave supported decomposition when compared with the control. These bacterial consortia have potential for further study of value-added by-product production during metabolism of lignocellulosic biomasses.

  1. Application of the ThinPrep Imaging System in Urine Cytology A Prospective Study

    NARCIS (Netherlands)

    van Hemel, Bettien M.; Haarsma, Jolanda G.; Ruitenbeek, Teus; Groen, Henk; Suurmeijer, Albert J. H.

    2013-01-01

    BACKGROUND In this prospective study, for the first time, the authors compared the accuracy of reading urine specimens using the ThinPrep Imager System (TIS) with the accuracy of conventional screening for the detection of abnormal urine cells. METHODS ThinPrep slides were made from 1455 urine speci

  2. Charter Schools as Nation Builders: Democracy Prep and Civic Education. Policy Brief 4

    Science.gov (United States)

    Lautzenheiser, Daniel; Kelly, Andrew P.

    2013-01-01

    This policy brief is the first in a series of in-depth case studies exploring how top-performing charter schools have incorporated civic learning in their school curriculum and school culture. This paper introduces Democracy Prep, a network of seven public charter schools with a civic mission at its core. Democracy Prep's founder and…

  3. Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.

    Directory of Open Access Journals (Sweden)

    Kentaro Yoshioka

    Full Text Available Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused late embryonic lethality associated with defective hematopoiesis and angiogenesis. In the present study, we generated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence causes significant hematopoietic abnormalities in the adult bone marrow. Loss of Prep1 promotes cell cycling of hematopoietic stem/progenitor cells (HSPC, leading to the expansion of the HSPC pool. Prep1 deficiency also results in the accumulation of lineage-committed progenitors, increased monocyte/macrophage differentiation and arrested erythroid maturation. Maturation of T cells and B cells is also perturbed in Prep-deficient mice. These findings provide novel insight into the pleiotropic roles of Prep1 in adult hematopoiesis that were unrecognized in previous studies using germline Prep1 hypomorphic mice.

  4. Regional Consortia for E-Resources: A Case Study of Deals in the South China Region

    Science.gov (United States)

    Chunrong, Luo; Jingfen, Wang; Zhinong, Zhou

    2010-01-01

    Purpose: The purpose of this paper is to analyse the current situation and the social and economic benefits from the consortia acquisitions of electronic resources by the China Academic Library and Information System (CALIS) South China Regional Centre and to recommend improvements for consortia acquisitions. Design/methodology/approach: Analyses…

  5. Operational Procedures for Successful Vocational-Technical Resource Consortia in Serving Business and Industry in Ohio.

    Science.gov (United States)

    Frasier, James E.; Stanton, William

    The development, organization, and operation of the Vocational-Technical Resource Consortia in Ohio was examined to identify those elements, policies, practices, and procedures that contribute to their effective operation and future growth. Data about individual consortia and general information were gathered by questionnaires completed by…

  6. Meeting Ohio's Need To Know about School-to-Work.

    Science.gov (United States)

    Ohio State Univ., Columbus. Coll. of Education.

    A needs assessment was conducted with six stakeholder groups in Ohio concerned with school-to-work (STW) transition (including educators on all levels, teacher educators, and administrators of STW regions, tech prep consortia, and Private Industry Councils) to determine if they need and would use a proposed STW clearinghouse. The needs assessment…

  7. The Vocational-Technical Resource Consortia Serving Business and Industry in Ohio. Digest of Study: Operational Procedures for Successful Vocational-Technical Resource Consortia in Serving Business and Industry in Ohio.

    Science.gov (United States)

    Frasier, James E.; Stanton, William

    This publication reports the development of the vocational-technical resource consortia in Ohio and identifies the operational procedures associated with successful programs. Five exemplary consortia were studied in some depth; however, data were obtained from all of the 23 consortia in the state. The research indicates that the consortium is an…

  8. What Role for Law, Human Rights, and Bioethics in an Age of Big Data, Consortia Science, and Consortia Ethics? The Importance of Trustworthiness

    Directory of Open Access Journals (Sweden)

    Edward S. Dove

    2015-08-01

    Full Text Available The global bioeconomy is generating new paradigm-shifting practices of knowledge co-production, such as collective innovation; large-scale, data-driven global consortia science (Big Science; and consortia ethics (Big Ethics. These bioeconomic and sociotechnical practices can be forces for progressive social change, but they can also raise predicaments at the interface of law, human rights, and bioethics. In this article, we examine one such double-edged practice: the growing, multivariate exploitation of Big Data in the health sector, particularly by the private sector. Commercial exploitation of health data for knowledge-based products is a key aspect of the bioeconomy and is also a topic of concern among publics around the world. It is exacerbated in the current age of globally interconnected consortia science and consortia ethics, which is characterized by accumulating epistemic proximity, diminished academic independence, “extreme centrism”, and conflicted/competing interests among innovation actors. Extreme centrism is of particular importance as a new ideology emerging from consortia science and consortia ethics; this relates to invariably taking a middle-of-the-road populist stance, even in the event of human rights breaches, so as to sustain the populist support needed for consortia building and collective innovation. What role do law, human rights, and bioethics—separate and together—have to play in addressing these predicaments and opportunities in early 21st century science and society? One answer we propose is an intertwined ethico-legal normative construct, namely trustworthiness. By considering trustworthiness as a central pillar at the intersection of law, human rights, and bioethics, we enable others to trust us, which in turns allows different actors (both nonprofit and for-profit to operate more justly in consortia science and ethics, as well as to access and responsibly use health data for public benefit.

  9. What Role for Law, Human Rights, and Bioethics in an Age of Big Data, Consortia Science, and Consortia Ethics? The Importance of Trustworthiness.

    Science.gov (United States)

    Dove, Edward S; Özdemir, Vural

    2015-09-01

    The global bioeconomy is generating new paradigm-shifting practices of knowledge co-production, such as collective innovation; large-scale, data-driven global consortia science (Big Science); and consortia ethics (Big Ethics). These bioeconomic and sociotechnical practices can be forces for progressive social change, but they can also raise predicaments at the interface of law, human rights, and bioethics. In this article, we examine one such double-edged practice: the growing, multivariate exploitation of Big Data in the health sector, particularly by the private sector. Commercial exploitation of health data for knowledge-based products is a key aspect of the bioeconomy and is also a topic of concern among publics around the world. It is exacerbated in the current age of globally interconnected consortia science and consortia ethics, which is characterized by accumulating epistemic proximity, diminished academic independence, "extreme centrism", and conflicted/competing interests among innovation actors. Extreme centrism is of particular importance as a new ideology emerging from consortia science and consortia ethics; this relates to invariably taking a middle-of-the-road populist stance, even in the event of human rights breaches, so as to sustain the populist support needed for consortia building and collective innovation. What role do law, human rights, and bioethics-separate and together-have to play in addressing these predicaments and opportunities in early 21st century science and society? One answer we propose is an intertwined ethico-legal normative construct, namely trustworthiness. By considering trustworthiness as a central pillar at the intersection of law, human rights, and bioethics, we enable others to trust us, which in turns allows different actors (both nonprofit and for-profit) to operate more justly in consortia science and ethics, as well as to access and responsibly use health data for public benefit.

  10. Mechatronics education at Virginia Tech

    Science.gov (United States)

    Bay, John S.; Saunders, William R.; Reinholtz, Charles F.; Pickett, Peter; Johnston, Lee

    1998-12-01

    The advent of more complex mechatronic systems in industry has introduced new opportunities for entry-level and practicing engineers. Today, a select group of engineers are reaching out to be more knowledgeable in a wide variety of technical areas, both mechanical and electrical. A new curriculum in mechatronics developed at Virginia Tech is starting to bring students from both the mechanical and electrical engineering departments together, providing them wit an integrated perspective on electromechanical technologies and design. The course is cross-listed and team-taught by faculty from both departments. Students from different majors are grouped together throughout the course, each group containing at least one mechanical and one electrical engineering student. This gives group members the ability to learn from one another while working on labs and projects.

  11. Fermentation enhancement of methanogenic archaea consortia from an Illinois basin coalbed via DOL emulsion nutrition.

    Directory of Open Access Journals (Sweden)

    Dong Xiao

    Full Text Available Microbially enhanced coalbed methane technology must be used to increase the methane content in mining and generate secondary biogenic gas. In this technology, the metabolic processes of methanogenic consortia are the basis for the production of biomethane from some of the organic compounds in coal. Thus, culture nutrition plays an important role in remediating the nutritional deficiency of a coal seam. To enhance the methane production rates for microorganism consortia, different types of nutrition solutions were examined in this study. Emulsion nutrition solutions containing a novel nutritional supplement, called dystrophy optional modification latex, increased the methane yield for methanogenic consortia. This new nutritional supplement can help methanogenic consortia form an enhanced anaerobic environment, optimize the microbial balance in the consortia, and improve the methane biosynthesis rate.

  12. Fermentation enhancement of methanogenic archaea consortia from an Illinois basin coalbed via DOL emulsion nutrition.

    Science.gov (United States)

    Xiao, Dong; Peng, Su-Ping; Wang, En-Yuan

    2015-01-01

    Microbially enhanced coalbed methane technology must be used to increase the methane content in mining and generate secondary biogenic gas. In this technology, the metabolic processes of methanogenic consortia are the basis for the production of biomethane from some of the organic compounds in coal. Thus, culture nutrition plays an important role in remediating the nutritional deficiency of a coal seam. To enhance the methane production rates for microorganism consortia, different types of nutrition solutions were examined in this study. Emulsion nutrition solutions containing a novel nutritional supplement, called dystrophy optional modification latex, increased the methane yield for methanogenic consortia. This new nutritional supplement can help methanogenic consortia form an enhanced anaerobic environment, optimize the microbial balance in the consortia, and improve the methane biosynthesis rate.

  13. [Health consortia: a case study of best practices].

    Science.gov (United States)

    Neves, Luiz Antonio; Ribeiro, José Mendes

    2006-10-01

    Local Health Consortia have been used as alternatives and innovative models for improving health care provision. They are closely linked to the strategy aimed at regionalizing health care in Brazil and are in keeping with the health sector's administrative reform process, seeking greater efficiency, rationality, and quality in the supply of services to the population. In the development of such forms of cooperation, we view some consortia as weak structures with a short lifespan, while others have survived for considerable lengths of time. This case study on the Penápolis Consortium, the oldest in Brazil (having lasted for 14 years), examines the dynamics of cooperation and the reasons for its sustainability. Its formation is a mixture of restructuring the regional supply and the entrepreneurial spirit of its leaders, along with State incentives. The Consortium's local capacity to solve cases with quality care and flexible management has proven to be an important factor. Participants share the important notion that the operational rules are fair, and the reasons for its success stem from the collective perception of reasonably symmetrical political gains as the result of political cooperation.

  14. Characterization of anaerobic consortia coupled lignin depolymerization with biomethane generation.

    Science.gov (United States)

    Wu, Yi-Rui; He, Jianzhong

    2013-07-01

    Two sediment-free microbial consortia (LI3 and LP3) were established to depolymerize lignin under anaerobic conditions. During depolymerizing high molecular weight lignin to low molecular weight molecules, the two cultures produced biomethane up to 151.7 and 113.0 mL g(-1) total lignin. Furthermore, LI3 and LP3 could also utilize the biomass - oil palm empty fruit bunch fiber (OPEFB) to produce 190.6 and 195.6 mL methaneg(-1) total lignin in OPEFB, and at the same time improve the bioavailability of lignocellulosic matters for further enzymatic hydrolysis. The microbial community analysis by denature gradient gel electrophoresis (DGGE) and the high-density 16S rDNA gene microarray (PhyloChip) exhibited that Methanomethylovorans sp. (LI3) and Methanoculleus sp. (LP3) were the main methanogens present, and phylum Firmicutes and Bacteroidetes were mainly involved in the lignin depolymerization. The established microbial consortia with both lignin depolymerization and biomethane production provide profound application on the environmental friendly pretreatment of lignocellulosic materials.

  15. Different cultivation methods to acclimatise ammonia-tolerant methanogenic consortia.

    Science.gov (United States)

    Tian, Hailin; Fotidis, Ioannis A; Mancini, Enrico; Angelidaki, Irini

    2017-05-01

    Bioaugmentation with ammonia tolerant-methanogenic consortia was proposed as a solution to overcome ammonia inhibition during anaerobic digestion process recently. However, appropriate technology to generate ammonia tolerant methanogenic consortia is still lacking. In this study, three basic reactors (i.e. batch, fed-batch and continuous stirred-tank reactors (CSTR)) operated at mesophilic (37°C) and thermophilic (55°C) conditions were assessed, based on methane production efficiency, incubation time, TAN/FAN (total ammonium nitrogen/free ammonia nitrogen) levels and maximum methanogenic activity. Overall, fed-batch cultivation was clearly the most efficient method compared to batch and CSTR. Specifically, by saving incubation time up to 150%, fed-batch reactors were acclimatised to nearly 2-fold higher FAN levels with a 37%-153% methanogenic activity improvement, compared to batch method. Meanwhile, CSTR reactors were inhibited at lower ammonia levels. Finally, specific methanogenic activity test showed that hydrogenotrophic methanogens were more active than aceticlastic methanogens in all FAN levels above 540mgNH3-NL(-1). Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. The 11th High-Tech Expo

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The 11th China Beijing International High-Tech Expo,themed as "high-tech Olympics and high-tech innovation",was rounded off successfully on the afternoon of May 25.The Expo,held as planned in such a special period of post-quake relief work,has shown us the power of technology and scientific spirit.It has not only given all the Chinese people the spiritual support and hope for the future but also opened a window for the international community to know more about the Beijing Oympic Games and the development of science and technology in China.

  17. Preventing Tech Aches: Using Smart Phones Wisely

    Science.gov (United States)

    ... Media Guidelines Copyright Permissions Preventing Tech Aches: Using Smart Phones Wisely BETHESDA, MD (Dec. 26, 2013) — If you received a new smart phone or tablet this holiday season, chances are you’ ...

  18. Human capital in low-tech manufacturing

    DEFF Research Database (Denmark)

    Hansen, Teis; Winther, Lars; Hansen, Ronnie Fibæk

    2014-01-01

    capital appears to be equally important for economic development in low-tech industries and, second, that the divide between the large urban regions, especially Copenhagen, and the rest of the country plays the primary role in explaining the geography of human capital. These findings stress the relevance......An essential feature associated with the rise of the knowledge economy has been the increasing focus on the importance of human capital as a precondition for economic growth. Human capital has been found to have a positive impact on the economic growth of high-tech industries, however......, the influence of human capital on the development of low-tech industries is yet to be analysed. This paper provides such an examination of low-tech industries based on an analysis of employment data within manufacturing industries in Denmark in the period 1993–2006. The findings highlight, first, that human...

  19. Governance of global health research consortia: Sharing sovereignty and resources within Future Health Systems.

    Science.gov (United States)

    Pratt, Bridget; Hyder, Adnan A

    2017-02-01

    Global health research partnerships are increasingly taking the form of consortia that conduct programs of research in low and middle-income countries (LMICs). An ethical framework has been developed that describes how the governance of consortia comprised of institutions from high-income countries and LMICs should be structured to promote health equity. It encompasses initial guidance for sharing sovereignty in consortia decision-making and sharing consortia resources. This paper describes a first effort to examine whether and how consortia can uphold that guidance. Case study research was undertaken with the Future Health Systems consortium, performs research to improve health service delivery for the poor in Bangladesh, China, India, and Uganda. Data were thematically analysed and revealed that proposed ethical requirements for sharing sovereignty and sharing resources are largely upheld by Future Health Systems. Facilitating factors included having a decentralised governance model, LMIC partners with good research capacity, and firm budgets. Higher labour costs in the US and UK and the funder's policy of allocating funds to consortia on a reimbursement basis prevented full alignment with guidance on sharing resources. The lessons described in this paper can assist other consortia to more systematically link their governance policy and practice to the promotion of health equity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.

    Directory of Open Access Journals (Sweden)

    Elisa Bernardi

    Full Text Available Prep1 is a developmentally essential TALE class homeodomain transcription factor. In zebrafish and mouse, Prep1 is already ubiquitously expressed at the earliest stages of development, with important tissue-specific peculiarities. The Prep1 gene in mouse is developmentally essential and has haploinsufficient tumor suppressor activity [1]. We have determined the human Prep1 transcription start site (TSS by primer extension analysis and identified, within 20 bp, the transcription start region (TSR of the zebrafish Prep1.1 promoter. The functions of the zebrafish 5' upstream sequences were analyzed both by transient transfections in Hela Cells and by injection in zebrafish embryos. This analysis revealed a complex promoter with regulatory sequences extending up to -1.8, possibly -5.0 Kb, responsible for tissue specific expression. Moreover, the first intron contains a conserved tissue-specific enhancer both in zebrafish and in human cells. Finally, a two nucleotides mutation of an EGR-1 site, conserved in all species including human and zebrafish and located at a short distance from the TSS, destroyed the promoter activity of the -5.0 Kb promoter. A transgenic fish expressing GFP under the -1.8 Kb zebrafish promoter/enhancer co-expressed GFP and endogenous Prep1.1 during embryonic development. In the adult fish, GFP was expressed in hematopoietic regions like the kidney, in agreement with the essential function of Prep1 in mouse hematopoiesis. Sequence comparison showed conservation from man to fish of the sequences around the TSS, within the first intron enhancer. Moreover, about 40% of the sequences spread throughout the 5 Kbof the zebrafish promoter are concentrated in the -3 to -5 Kb of the human upstream region.

  1. Fungal degradation of pesticides - construction of microbial consortia for bioremediation

    DEFF Research Database (Denmark)

    Ellegaard-Jensen, Lea

    in groundwater contamination. New technologies are therefore needed for cleaning up contaminated soil and water resources. This PhD was part of the project entitled Microbial Remediation of Contaminated Soil and Water Resources (MIRESOWA) where the overall aim is to develop new technologies for bioremediation...... of pesticide contaminated soil and water. The objectives of this PhD were to investigate fungal degradation of pesticides and following to construct microbial consortia for bioremediation. In Manuscript I the fungal degradation of the phenylurea herbicide diuron was studied. Isolates of soil fungi of the genus...... be a result of co-operative catabolism or physical interactions between the organisms improving growth and/or distribution of fungi and bacteria. The bacterial strains applied were Sphingomonas sp. SRS2, Variovorax sp. SRS16 and Arthrobacter globiformis D47 and the fungal strains were Mortierella sp. LEJ702...

  2. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi

    Science.gov (United States)

    Arnold, Trisha; Brinkley-Rubinstein, Lauren; Chan, Philip A.; Perez-Brumer, Amaya; Bologna, Estefany S.; Beauchamps, Laura; Johnson, Kendra; Mena, Leandro; Nunn, Amy

    2017-01-01

    Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi. Thirty MSM who were prescribed PrEP at an outpatient primary care clinic were interviewed and included 23 men who had been retained in PrEP care and seven who had not been retained. The mean age of participants was 26.6 years. Most (23) participants were African American. Major factors affecting PrEP use and retention in PrEP care included 1) structural factors such as cost and access to financial assistance for medications and clinical services; 2) social factors such as stigma and relationship status; 3) behavioral factors including sexual risk behaviors; and 4) clinical factors such as perceived and actual side effects. Many participants also discussed the positive spillover effects of PrEP use and reported that PrEP had a positive impact on their health. Four of the seven individuals who had not been retained re-enrolled in PrEP care after completing their interviews, suggesting that case management and ongoing outreach can enhance retention in PrEP care. Interventions to enhance retention in PrEP care among MSM in the Deep South will be most effective if they address the complex structural, social, clinical, and behavioral factors that influence PrEP uptake and retention in PrEP care. PMID:28222118

  3. NASA Tech Briefs, February 2009

    Science.gov (United States)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: Measuring Low Concentrations of Liquid Water in Soil; The Mars Science Laboratory Touchdown Test Facility; Non-Contact Measurement of Density and Thickness Variation in Dielectric Materials; Compact Microwave Fourier Spectrum Analyzer; InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz; Combinatorial Generation of Test Suites; In-Phase Power-Combined Frequency Tripler at 300 GHz; Electronic System for Preventing Airport Runway Incursions; Smaller but Fully Functional Backshell for Cable Connector; Glove-Box or Desktop Virtual-Reality System; Composite Layer Manufacturing with Fewer Interruptions; Improved Photoresist Coating for Making CNT Field Emitters; A Simplified Diagnostic Method for Elastomer Bond Durability; Complex Multifunctional Polymer/Carbon-Nanotube Composites; Very High Output Thermoelectric Devices Based on ITO Nanocomposites; Reducing Unsteady Loads on a Piggyback Miniature Submarine; Ultrasonic/Sonic Anchor; Grooved Fuel Rings for Nuclear Thermal Rocket Engines; Pulsed Operation of an Ion Accelerator; Autonomous Instrument Placement for Mars Exploration Rovers; Mission and Assets Database; TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP); Trajectory Calculator for Finite-Radius Cutter on a Lathe; Integrated System Health Management Development Toolkit.

  4. MICROBIAL CONSORTIA ENGINEERING FOR CELLULAR FACTORIES: IN VITRO TO IN SILICO SYSTEMS

    Directory of Open Access Journals (Sweden)

    Hans C Bernstein

    2012-10-01

    Full Text Available This mini-review discusses the current state of experimental and computational microbial consortia engineering with a focus on cellular factories. A discussion of promising ecological theories central to community resource usage is presented to facilitate interpretation of consortial designs. Recent case studies exemplifying different resource usage motifs and consortial assembly templates are presented. The review also highlights in silico approaches to design and to analyze consortia with an emphasis on stoichiometric modeling methods. The discipline of microbial consortia engineering possesses a widely accepted potential to generate highly novel and effective bio-catalysts for applications from biofuels to specialty chemicals to enhanced mineral recovery.

  5. SKILL PREP Program for American Indian Students. Final report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    McCulloh, S.; Huebner, P.

    1995-10-01

    The Scientific Knowledge for Indian Learning and Leadership (SKILL) precollege college program of the South Dakota School of Mines and Technology concluded the 1994 PREP program on July 22, 1994. The program graduated 22 students from the 4-week residential math/science program for American Indian students. Primary academic focus was physics (30 hours); each student was given a bicycle to solve problems on angular momentum and mechanical advantage. Mathematical calculations and problem solving exercises were done in mathematics class (20 hours). Preliminary results in math, physics, and geology show dramatic increases in student achievement over the 4- week period. The program paired every two students with a faculty member or research scientist, and each team completed a research project.

  6. Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

    Science.gov (United States)

    Oriente, Francesco; Fernandez Diaz, Luis Cesar; Miele, Claudia; Iovino, Salvatore; Mori, Silvia; Diaz, Victor Manuel; Troncone, Giancarlo; Cassese, Angela; Formisano, Pietro; Blasi, Francesco; Beguinot, Francesco

    2008-09-01

    We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by skeletal muscle. This muscle phenotype does not depend on reduced expression of the known Prep1 transcription partner, Pbx1. Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160. Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle. Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1. In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype. Finally, we show that Prep1 controls the stability of the p160 protein. We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.

  7. Efficient endotoxin removal with a new sanitizable affinity column: Affi-Prep Polymyxin.

    Science.gov (United States)

    Talmadge, K W; Siebert, C J

    1989-08-04

    A new affinity column packing for removal of endotoxins has been prepared by coupling USP drug-quality polymyxin B to Affi-Prep, a novel synthetic macroporous polymer. Affi-Prep Polymyxin binds endotoxins from a number of different strains of gram-negative bacteria. Endotoxin binding is not significantly affected by 10 mg/ml of bovine serum albumin or human immunoglobulin G, by 1 mg/ml sodium dodecyl sulphate, or by 1 mg/ml deoxycholate. Affi-Prep Polymyxin is stable to treatment with 1.0 M sodium hydroxide, an important property for sanitizing the resin. The resin shows a high ligand stability, since no leakage of polymyxin B from the packing could be detected. Affi-Prep Polymyxin exhibited the highest endotoxin binding efficiency when compared with several commercial agarose affinity packings.

  8. Preliminary investigation of the advertising and availability of PREPs, the new "safe" tobacco products.

    Science.gov (United States)

    Hickman, Norval; Klonoff, Elizabeth A; Landrine, Hope; Kashima, Kennon; Parekh, Bina; Fernandez, Senaida; Thomas, Kamala; Brouillard, Catherine; Zolezzi, Michele; Jensen, Jennifer; Weslowski, Zorahna

    2004-08-01

    The tobacco industry recently introduced a new set of "safe" cigarettes and nicotine delivery devices that purportedly entail reduced tobacco-related disease risk due to their lower level of some carcinogens and toxins. Little is know about the biological impact of these potential reduced exposure products (PREPs) and nothing is known about their advertising and availability. Hence, two pilot studies were conducted to examine the latter issues for the first time. In Study 1, we examined tobacco ads in 10 popular magazines 1998--2002 and found that only 1% of ads were for PREPs. In Study 2, we attempted to purchase PREPs in a random sample of 113 small stores and found that only 4.4% sold any PREP. These preliminary findings tentatively suggest that the industry might not yet be heavily invested in products that have the potential to increase tobacco use by decreasing its perceived harm. Studies with larger samples are recommended.

  9. Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.

    Science.gov (United States)

    Mathiasen, Lisa; Bruckmann, Chiara; Pasqualato, Sebastiano; Blasi, Francesco

    2015-01-01

    Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high instability and insufficient purity, in particular for structural studies. We cloned the cDNA of both proteins into a dicistronic vector containing an N-terminal glutathione S-transferase (GST) tag and co-expressed and co-purified a stable PBX1:PREP1 complex. For structural studies, we produced two C-terminally truncated complexes that retain their ability to bind DNA and are more stable than the full-length proteins through various purification steps. Here we report the production of large amounts of soluble and pure recombinant human PBX1:PREP1 complex in an active form capable of binding DNA.

  10. Microbial consortia in Oman oil fields: a possible use in enhanced oil recovery.

    Science.gov (United States)

    Al-Bahry, Saif N; Elshafie, Abdulkader E; Al-Wahaibi, Yahya M; Al-Bemani, Ali S; Joshi, Sanket J; Al-Maaini, Ratiba A; Al-Alawi, Wafa J; Sugai, Yuichi; Al-Mandhari, Mussalam

    2013-01-01

    Microbial enhanced oil recovery (MEOR) is one of the most economical and efficient methods for extending the life of production wells in a declining reservoir. Microbial consortia from Wafra oil wells and Suwaihat production water, Al-Wusta region, Oman were screened. Microbial consortia in brine samples were identified using denaturing gradient gel electrophoresis and 16S rRNA gene sequences. The detected microbial consortia of Wafra oil wells were completely different from microbial consortia of Suwaihat formation water. A total of 33 genera and 58 species were identified in Wafra oil wells and Suwaihat production water. All of the identified microbial genera were first reported in Oman, with Caminicella sporogenes for the first time reported from oil fields. Most of the identified microorganisms were found to be anaerobic, thermophilic, and halophilic, and produced biogases, biosolvants, and biosurfactants as by-products, which may be good candidates for MEOR.

  11. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Directory of Open Access Journals (Sweden)

    Daniel A Felix

    2010-04-01

    Full Text Available Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is

  12. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Science.gov (United States)

    Felix, Daniel A; Aboobaker, A Aziz

    2010-04-22

    Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi) animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation) to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is required for

  13. Novel bacterial consortia isolated from plastic garbage processing areas demonstrated enhanced degradation for low density polyethylene.

    Science.gov (United States)

    Skariyachan, Sinosh; Manjunatha, Vishal; Sultana, Subiya; Jois, Chandana; Bai, Vidya; Vasist, Kiran S

    2016-09-01

    This study aimed to formulate novel microbial consortia isolated from plastic garbage processing areas and thereby devise an eco-friendly approach for enhanced degradation of low-density polyethylene (LDPE). The LDPE degrading bacteria were screened and microbiologically characterized. The best isolates were formulated as bacterial consortia, and degradation efficiency was compared with the consortia formulated using known isolates obtained from the Microbial Culture Collection Centre (MTCC). The degradation products were analyzed by FTIR, GC-FID, tensile strength, and SEM. The bacterial consortia were characterized by 16S ribosomal DNA (rDNA) sequencing. The formulated bacterial consortia demonstrated 81 ± 4 and 38 ± 3 % of weight reduction for LDPE strips and LDPE pellets, respectively, over a period of 120 days. However, the consortia formulated by MTCC strains demonstrated 49 ± 4 and 20 ± 2 % of weight reduction for LDPE strips and pellets, respectively, for the same period. Furthermore, the three isolates in its individual application exhibited 70 ± 4, 68 ± 4, and 64 ± 4 % weight reduction for LDPE strips and 21 ± 2, 28 ± 2, 24 ± 2 % weight reduction for LDPE pellets over a period of 120 days (p product analysis showed structural changes and formation of bacterial film on degraded LDPE strips. The 16S rDNA characterization of bacterial consortia revealed that these organisms were novel strains and designated as Enterobacter sp. bengaluru-btdsce01, Enterobacter sp. bengaluru-btdsce02, and Pantoea sp. bengaluru-btdsce03. The current study thus suggests that industrial scale-up of these microbial consortia probably provides better insights for waste management of LDPE and similar types of plastic garbage.

  14. Fungal–bacterial consortia increase diuron degradation in water-unsaturated systems

    DEFF Research Database (Denmark)

    Ellegaard-Jensen, Lea; Knudsen, Berith Elkær; Johansen, Anders;

    2014-01-01

    Abstract Bioremediation of pesticide-polluted soil may be more efficient using mixed fungal–bacterial cultures rather than the individual strains alone. This may be due to cooperative catabolism, where the first organism transforms the pollutant to products which are then used by the second......-member consortia. This study demonstrates new possibilities for applying efficient fungal–bacterial consortia for bioremediation of polluted soil....

  15. Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.

    Science.gov (United States)

    Longobardi, E; Penkov, D; Mateos, D; De Florian, G; Torres, M; Blasi, Francesco

    2014-01-01

    TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction surfaces. Members of the three sets of protein form dimers in which the common partner is PBX but they can also directly interact with other proteins forming higher-order complexes, in particular HOX. Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed. These studies have generated a few general rules that can be applied to all members of the three gene families. PREP and MEIS recognize slightly different consensus sequences: PREP prefers to bind to promoters and to have PBX as a DNA-binding partner; MEIS prefers HOX as partner, and both PREP and MEIS drive PBX to their own binding sites. This outlines the clear individuality of the PREP and MEIS proteins, the former mostly devoted to basic cellular functions, the latter more to developmental functions.

  16. Community dynamics and glycoside hydrolase activities of thermophilic bacterial consortia adapted to switchgrass

    Energy Technology Data Exchange (ETDEWEB)

    Gladden, J.M.; Allgaier, M.; Miller, C.S.; Hazen, T.C.; VanderGheynst, J.S.; Hugenholtz, P.; Simmons, B.A.; Singer, S.W.

    2011-05-01

    Industrial-scale biofuel production requires robust enzymatic cocktails to produce fermentable sugars from lignocellulosic biomass. Thermophilic bacterial consortia are a potential source of cellulases and hemicellulases adapted to harsher reaction conditions than commercial fungal enzymes. Compost-derived microbial consortia were adapted to switchgrass at 60 C to develop thermophilic biomass-degrading consortia for detailed studies. Microbial community analysis using small-subunit rRNA gene amplicon pyrosequencing and short-read metagenomic sequencing demonstrated that thermophilic adaptation to switchgrass resulted in low-diversity bacterial consortia with a high abundance of bacteria related to thermophilic paenibacilli, Rhodothermus marinus, and Thermus thermophilus. At lower abundance, thermophilic Chloroflexi and an uncultivated lineage of the Gemmatimonadetes phylum were observed. Supernatants isolated from these consortia had high levels of xylanase and endoglucanase activities. Compared to commercial enzyme preparations, the endoglucanase enzymes had a higher thermotolerance and were more stable in the presence of 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]), an ionic liquid used for biomass pretreatment. The supernatants were used to saccharify [C2mim][OAc]-pretreated switchgrass at elevated temperatures (up to 80 C), demonstrating that these consortia are an excellent source of enzymes for the development of enzymatic cocktails tailored to more extreme reaction conditions.

  17. Preferences for HIV pre-exposure prophylaxis (PrEP) information among men-who-have-sex-with-men (MSM) at community outreach settings

    Science.gov (United States)

    Merchant, Roland C.; Corner, David; Garza, Eduardo; Guan, Wentao; Mayer, Kenneth H.; Brown, Larry; Chan, Philip A

    2016-01-01

    Community outreach efforts to increase HIV pre-exposure prophylaxis (PrEP) utilization by at risk men-who-have-sex-with-men (MSM) first need to elucidate preferences for learning about PrEP and linking to PrEP resources. In this pilot study, we observed that among MSM recruited through community outreach, HIV sexual risk-taking was significant, yet self-perceived PrEP knowledge was low and interest in learning more about PrEP was moderate. Most preferred learning about PrEP and being provided local PrEP clinic information through electronic media. However, receipt of PrEP information alone did not appear to motivate these men into presenting to a local clinic for PrEP evaluation. PMID:27076865

  18. Airport Noise Tech Challenge Overview

    Science.gov (United States)

    Bridges, James

    2011-01-01

    The Supersonics Project, operating under NASA Aeronautics Mission Directorate#s Fundamental Aero Program, has been organized around the Technical Challenges that have historically precluded commercial supersonic flight. One of these Challenges is making aircraft that are capable of such high aerodynamic performance quiet enough around airports that they will not be objectionable. It is recognized that a successful civilian supersonic aircraft will be a system where many new technologies will come together, and for this to happen not only will new low noise propulsion concepts be required, but new engineering tools that predict the noise of the aircraft as these technologies are combined and compromised with the rest of the aircraft design. These are the two main objectives of the Airport Noise Tech Challenge. " ! As a Project in the Fundamental Aero Program, we work at a relatively low level of technology readiness. However, we have high level milestones which force us to integrate our efforts to impact systems-level activities. To keep the low-level work tied to delivering engineering tools and low-noise concepts, we have structured our milestones around development of the concepts and organized our activities around developing and applying our engineering tools to these concepts. The final deliverables in these milestones are noise prediction modules validated against the best embodiment of each concept. These will then be used in cross-disciplinary exercises to demonstrate the viability of aircraft designs to meet all the Technical Challenges. Some of the concepts being developed are shown: Fan Flow Diverters, Multi-jet Shielding, High-Aspect Ratio Embedded Nozzles, Plasma Actuated Instability Manipulation, Highly Variable Cycle Mixer- Ejectors, and Inverted Velocity Profiles. These concepts are being developed for reduced jet noise along with the design tools which describe how they perform when used in various aircraft configurations. Several key upcoming

  19. Interpersonal Communication in High Tech Culture: Eastern or Western?

    Science.gov (United States)

    Isenhart, Myra W.

    1987-01-01

    Investigates interpersonal communication in a high tech organization to test the association between high tech organizations and Western styles of symbolic interaction. Takes a diagnostic, rather than prescriptive, approach to organizational change. (MM)

  20. Pyrolysis kinetics of algal consortia grown using swine manure wastewater.

    Science.gov (United States)

    Sharara, Mahmoud A; Holeman, Nathan; Sadaka, Sammy S; Costello, Thomas A

    2014-10-01

    In this study, pyrolysis kinetics of periphytic microalgae consortia grown using swine manure slurry in two seasonal climatic patterns in northwest Arkansas were investigated. Four heating rates (5, 10, 20 and 40 °C min(-1)) were used to determine the pyrolysis kinetics. Differences in proximate, ultimate, and heating value analyses reflected variability in growing substrate conditions, i.e., flocculant use, manure slurry dilution, and differences in diurnal solar radiation and air temperature regimes. Peak decomposition temperature in algal harvests varied with changing the heating rate. Analyzing pyrolysis kinetics using differential and integral isoconversional methods (Friedman, Flynn-Wall-Ozawa, and Kissinger-Akahira-Sunose) showed strong dependency of apparent activation energy on the degree of conversion suggesting parallel reaction scheme. Consequently, the weight loss data in each thermogravimetric test was modeled using independent parallel reactions (IPR). The quality of fit (QOF) for the model ranged between 2.09% and 3.31% indicating a good agreement with the experimental data.

  1. Theoretical Study of Agricultural High-tech Industrialization

    Institute of Scientific and Technical Information of China (English)

    Jian; XU; Xianming; WU

    2013-01-01

    This paper introduces the characteristics of the agricultural high-tech industries,and points out that the agricultural high-tech industries are intelligence-intensive and knowledge-intensive industries with the characteristics of high investment,high risk,high value-added, which focuses on constant innovation,having strong horizontal and vertical linkages with other enterprises and showing the trend of internationalization.The connotation of agricultural high-tech industrialization is analyzed as follows:Agricultural high-tech industrialization is the process of transformation of the agricultural high-tech achievements to the agricultural high-tech industries; essentially the marketization and commercialization of agricultural high technology; the manifestation of scale and level of agricultural high-tech industries; the manifestation of social impact,social status and social role of agricultural high-tech industries.The development strategies are put forward for agricultural high-tech industrialization:(1) Bringing the research of agricultural high technology into the orbit of the market economy; (2) Implementing the new mechanism to closely link agricultural high technology with modern rural enterprises; (3) Building the agricultural high-tech team with a larger size and high level; (4) Further improving the construction of the agricultural high-tech industrial development zone; (5) Solving the issues concerning agricultural intellectual property and patent; (6) Increasing policy guidance and support efforts for agricultural high-tech industries.

  2. The High-Tech Industry and Its Workers

    Science.gov (United States)

    Kirk, James; Belovics, Robert

    2007-01-01

    The purpose of this article is to provide counselors, academic advisers, and career coaches with a basic understanding of the current state of the high-technology (high-tech) industry in the United States and the people who work in it. A profile of a high-tech worker is presented, several high-tech career developments are described, and selected…

  3. Identification, visualization, and sorting of translationally active microbial consortia from deep-sea methane seeps

    Science.gov (United States)

    Hatzenpichler, R.; Connon, S. A.; Goudeau, D.; Malmstrom, R.; Woyke, T.; Orphan, V. J.

    2015-12-01

    Within the past few years, great progress has been made in tapping the genomes of individual cells separated from environmental samples. Unfortunately, however, most often these efforts have been target blind, as they did not pre-select for taxa of interest or focus on metabolically active cells that could be considered key species of the system at the time. This problem is particularly pronounced in low-turnover systems such as deep sea sediments. In an effort to tap the genetic potential hidden within functionally active cells, we have recently developed an approach for the in situ fluorescent tracking of protein synthesis in uncultured cells via bioorthogonal non-canonical amino acid-tagging (BONCAT). This technique depends on the incorporation of synthetic amino acids that carry chemically modifiable tags into newly made proteins, which later can be visualized via click chemistry-mediated fluorescence-labeling. BONCAT is thus able to specifically target proteins that have been expressed in reaction to an experimental condition. We are particularly interested in using BONCAT to understand the functional potential of slow-growing syntrophic consortia of anaerobic methanotrophic archaea and sulfate-reducing bacteria which together catalyze the anaerobic oxidation of methane (AOM) in marine methane seeps. In order to specifically target consortia that are active under varying environmental regimes, we are studying different subpopulations of these inter-domain consortia via a combination of BONCAT with rRNA-targeted FISH. We then couple the BONCAT-enabled staining of active consortia with their separation from inactive members of the community via fluorescence-activated cell-sorting (FACS) and metagenomic sequencing of individual consortia. Using this approach, we were able to identify previously unrecognized AOM-partnerships. By comparing the mini-metagenomes obtained from individual consortia with each other we are starting to gain a more hollistic understanding

  4. Biodegradation Of Thiocyanate Using Microbial Consortia Cultured From Gold Mine Tailings

    Science.gov (United States)

    Moreau, J. W.; Watts, M. P.; Spurr, L. P.; Vu, H. P.

    2015-12-01

    Some bacteria possess the capability to degrade SCN-; therefore, harnessing this metabolic trait offers a biotechnological remediation strategy for SCN- produced in gold ore processing. A tailings storage facility (TSF) at a gold mine in Victoria, Australia holds large quantities of thiocyanate (SCN-) contaminated mine waste. The surface water in the TSF typically contains SCN- concentrations of >800 mg L-1, and seepage from the facility has contaminated the groundwater at the site. This study aimed to culture SCN-degrading microbes from the TSF, characterize the microbial consortia and test its operational parameters for use in a thiocyanate-degrading bioreactor. Surface samples were obtained from several locations around the TSF facility and used to inoculate medium reflective of the moderately saline and alkaline tailings water at the TSF, in the absence of organic carbon but subject to additions of phosphate and trace metals. Four microbial consortia capable of rapid SCN- degradation were successfully cultured. Sequencing of 16S rRNA genes found that the consortia were dominated by Thiobacillus species, a genus of known SCN- degraders. Lower abundances of other SCN- degraders; Sphingopyxis and Rhodobacter, were also identified. The impact of a number of geochemical conditions, including pH, temperature and SCN- concentration, upon the growth and SCN- degrading capacity of these consortia was determined. These results informed the optimization of a lab-scale thiocyanate degrading bioreactor. In summary, the cultured bacterial consortia proved effective towards SCN- degradation at the prevailing geochemical conditions of the TSF, requiring minimal nutrient additions. These consortia were dominated by genera of known autotrophic SCN- degraders. The comprehensive characterisation of these SCN- degrading consortia will provide the fundamental operational parameters required for deployment of this technique at the field scale.

  5. Role of the pharmacist in pre-exposure chemoprophylaxis (PrEP) therapy for HIV prevention.

    Science.gov (United States)

    Clauson, Kevin A; Polen, Hyla H; Joseph, Shine A; Zapantis, Antonia

    2009-01-01

    With a global estimate of 2.5 million new infections of HIV occurring yearly, discovering novel methods to help stem the spread of the virus is critical. The use of antiretroviral chemoprophylaxis for preventing HIV after accidental or occupational exposure and in maternal to fetal transmission has become a widely accepted method to combat HIV. Based on this success, pre-exposure chemoprophylaxis (PrEP) is being explored in at-risk patient populations such as injecting drug users, female sex workers and men who have sex with men. This off-label and unmonitored use has created a need for education and intervention by pharmacists and other healthcare professionals. Pharmacists should educate themselves on PrEP and be prepared to counsel patients about their means of obtaining it (e.g. borrowing or sharing medications and ordering from disreputable Internet pharmacies). They should also be proactive about medication therapy management in these patients due to clinically important drug interactions with PrEP medications. Only one trial exploring the safety and efficacy of tenofovir as PrEP has been completed thus far. However, five ongoing trials are in various stages and two additional studies are scheduled for the near future. Unfortunately, studies in this arena have met with many challenges that have threatened to derail progress. Ethical controversy surrounding post-trial care of participants who seroconvert during studies, as well as concerns over emerging viral resistance and logistical site problems, have already halted several PrEP trials. Information about these early trials has already filtered down to affected individuals who are experimenting with this unproven therapy as an "evening before pill". The potential for PrEP is promising; however, more extensive trials are necessary to establish its safety and efficacy. Pharmacists are well-positioned to play a key role in helping patients make choices about PrEP, managing their therapy, and developing policy

  6. URBox : High tech energy and informal housing

    NARCIS (Netherlands)

    Cuperus, Y.J.; Smets, D.

    2011-01-01

    This paper reports on the URBox concept encompassing the high tech end of solar energy and informal low cost and affordable housing. It aims to contribute to solving the global energy crisis by building solar energy settlements in deserts where land is affordable and sunshine in abundance. First the

  7. Development of High-Tech Skills.

    Science.gov (United States)

    Theuerkauf, Walter E.

    High tech systems not only generate new structures in the production process, but also involve profound changes in job organization, which in turn imply that job qualifications must be modified. In view of the changes within engineering systems and the relevant technologies, it seems expedient to choose a curricular approach based on the concepts…

  8. Virginia Tech opens Engineering Communications Center

    OpenAIRE

    2006-01-01

    In an attempt to provide the engineers of the 21st Century with top-notch professional skills to complement their technical expertise, Virginia Tech, one of ten largest undergraduate engineering programs in the country, has opened an Engineering Communication Center.

  9. URBox : High tech energy and informal housing

    NARCIS (Netherlands)

    Cuperus, Y.J.; Smets, D.

    2011-01-01

    This paper reports on the URBox concept encompassing the high tech end of solar energy and informal low cost and affordable housing. It aims to contribute to solving the global energy crisis by building solar energy settlements in deserts where land is affordable and sunshine in abundance. First the

  10. Senior Military Colleges Meet At Virginia Tech

    OpenAIRE

    Lovegrove, Richard L.

    2003-01-01

    Representatives from the nation's six senior military colleges will hear from the Department of Defense and national Reserve Officer Training Corps (ROTC) commanders during the annual Senior Military Colleges Conference at Virginia Tech on Wednesday and Thursday, Sept. 17 and 18 at the Donaldson Brown Hotel and Conference Center.

  11. Virginia Tech student receives Student Leadership Award

    OpenAIRE

    Dickerson, Susan

    2004-01-01

    The Outstanding Undergraduate Student Leader Award is one of 10 University Student Leadership Awards given annually by Virginia Tech's Department of Student Activities in the Division of Student Affairs to recognize outstanding members, extraordinary achievements by an organization, advisers, volunteerism, and service-learning experiences.

  12. Planning and Designing Today's Career Tech Facility

    Science.gov (United States)

    Seaman, James

    2010-01-01

    During the past 20 years, career and technical education (CTE) has gone through significant changes. CTE has evolved in response to the changes technology has had on the job market. Preparing students for high-tech, high-skill job opportunities is the new focus. The facilities that house these programs, however, have not kept pace with these…

  13. Community flux balance analysis for microbial consortia at balanced growth.

    Directory of Open Access Journals (Sweden)

    Ruchir A Khandelwal

    Full Text Available A central focus in studies of microbial communities is the elucidation of the relationships between genotype, phenotype, and dynamic community structure. Here, we present a new computational method called community flux balance analysis (cFBA to study the metabolic behavior of microbial communities. cFBA integrates the comprehensive metabolic capacities of individual microorganisms in terms of (genome-scale stoichiometric models of metabolism, and the metabolic interactions between species in the community and abiotic processes. In addition, cFBA considers constraints deriving from reaction stoichiometry, reaction thermodynamics, and the ecosystem. cFBA predicts for communities at balanced growth the maximal community growth rate, the required rates of metabolic reactions within and between microbes and the relative species abundances. In order to predict species abundances and metabolic activities at the optimal community growth rate, a nonlinear optimization problem needs to be solved. We outline the methodology of cFBA and illustrate the approach with two examples of microbial communities. These examples illustrate two useful applications of cFBA. Firstly, cFBA can be used to study how specific biochemical limitations in reaction capacities cause different types of metabolic limitations that microbial consortia can encounter. In silico variations of those maximal capacities allow for a global view of the consortium responses to various metabolic and environmental constraints. Secondly, cFBA is very useful for comparing the performance of different metabolic cross-feeding strategies to either find one that agrees with experimental data or one that is most efficient for the community of microorganisms.

  14. Rethinking HIV prevention to prepare for oral PrEP implementation for young African women

    Directory of Open Access Journals (Sweden)

    Connie L Celum

    2015-07-01

    Full Text Available Introduction: HIV incidence remains high among young women in sub-Saharan Africa in spite of scale-up of HIV testing, behavioural interventions, antiretroviral treatment and medical male circumcision. There is a critical need to critique past approaches and learn about the most effective implementation of evidence-based HIV prevention strategies, particularly emerging interventions such as pre-exposure prophylaxis (PrEP. Discussion: Women in sub-Saharan Africa are at increased risk of HIV during adolescence and into their 20s, in part due to contextual factors including gender norms and relationship dynamics, and limited access to reproductive and sexual health services. We reviewed behavioural, behavioural economic and biomedical approaches to HIV prevention for young African women, with a particular focus on the barriers, opportunities and implications for implementing PrEP in this group. Behavioural interventions have had limited impact in part due to not effectively addressing the context, broader sexual norms and expectations, and structural factors that increase risk and vulnerability. Of biomedical HIV prevention strategies that have been tested, daily oral PrEP has the greatest evidence for protection, although adherence was low in two placebo-controlled trials in young African women. Given high efficacy and effectiveness in other populations, demonstration projects of open-label PrEP in young African women are needed to determine the most effective delivery models and whether women at substantial risk are motivated and able to use oral PrEP with sufficient adherence to achieve HIV prevention benefits. Conclusions: Social marketing, adherence support and behavioural economic interventions should be evaluated as part of PrEP demonstration projects among young African women in terms of their effectiveness in increasing demand and optimizing uptake and effective use of PrEP. Lessons learned through evaluations of implementation strategies

  15. PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study.

    Science.gov (United States)

    Cremin, Ide; McKinnon, Lyle; Kimani, Joshua; Cherutich, Peter; Gakii, Gloria; Muriuki, Festus; Kripke, Katharine; Hecht, Robert; Kiragu, Michael; Smith, Jennifer; Hinsley, Wes; Gelmon, Lawrence; Hallett, Timothy B

    2017-05-01

    The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget and to identify the circumstances in which pre-exposure prophylaxis (PrEP) could be used in Nairobi, Kenya. A mathematical model was developed to represent HIV transmission in specific key populations (female sex workers, male sex workers, and men who have sex with men [MSM]) and among the wider population of Nairobi. The scale-up of existing interventions (condom promotion, antiretroviral therapy, and male circumcision) for key populations and the wider population as have occurred in Nairobi is represented. The model includes a detailed representation of a PrEP intervention and is calibrated to prevalence and incidence estimates specific to key populations and the wider population. In the context of a declining epidemic overall but with a large sub-epidemic in MSM and male sex workers, an optimal prevention portfolio for Nairobi should focus on condom promotion for male sex workers and MSM in particular, followed by improved antiretroviral therapy retention, earlier antiretroviral therapy, and male circumcision as the budget allows. PrEP for male sex workers could enter an optimal portfolio at similar levels of spending to when earlier antiretroviral therapy is included; however, PrEP for MSM and female sex workers would be included only at much higher budgets. If PrEP for male sex workers cost as much as US$500, average annual spending on the interventions modelled would need to be less than $3·27 million for PrEP for male sex workers to be excluded from an optimal portfolio. Estimated costs per infection averted when providing PrEP to all female sex workers regardless of their risk of infection, and to high-risk female sex workers only, are $65 160 (95% credible interval [CrI] $43 520-$90 250) and $10 920 (95% CrI $4700

  16. Comparative Study of Soluble Sulfate Reduction by Bacterial Consortia from Varied Regions of India

    Directory of Open Access Journals (Sweden)

    Poonam Nasipuri

    2010-01-01

    Full Text Available Soluble sulfate contamination in water is observed due to various industrial activities. Chemical means of reduction are available yet the biological approach is the preferred one. Problem statement: The problem addressed in this study was the isolation of efficient sulfate reducing bacterial consortia for bioremediation of soluble sulfate from mining effluent. Approach: The culture based method using the DSMZ specific media were used for isolation of sulfate reducing bacterial consortia. Their reduction efficiency was measured spectrophotometrically following growth under varied temperature and pH in specified media as well as in effluent water. The microbial consortia were analyzed at the 16SrDNA level to identify the members. The completeness as well as richness of the study was analyzed using OTU saturation curve, Shannon diversity index and equitability index. Results: All the eight consortia were able to tolerate vide range of pH (6-9 and temperature (20-40°C. They could reduce 63-99% of soluble sulfate (~2000 ppm in 48 h. Conclusion: This study reported about the enrichment of few of the most efficient anaerobic microbial consortia that could be employed for environmental soluble sulfate reduction under diverse pH and temperature conditions.

  17. Surveillance indicators for potential reduced exposure products (PREPs: developing survey items to measure awareness

    Directory of Open Access Journals (Sweden)

    McNeill Ann

    2009-10-01

    Full Text Available Abstract Background Over the past decade, tobacco companies have introduced cigarettes and smokeless tobacco products (known as Potential Reduced Exposure Products, PREPs with purportedly lower levels of some toxins than conventional cigarettes and smokeless products. It is essential that public health agencies monitor awareness, interest, use, and perceptions of these products so that their impact on population health can be detected at the earliest stages. Methods This paper reviews and critiques existing strategies for measuring awareness of PREPs from 16 published and unpublished studies. From these measures, we developed new surveillance items and subjected them to two rounds of cognitive testing, a common and accepted method for evaluating questionnaire wording. Results Our review suggests that high levels of awareness of PREPs reported in some studies are likely to be inaccurate. Two likely sources of inaccuracy in awareness measures were identified: 1 the tendency of respondents to misclassify "no additive" and "natural" cigarettes as PREPs and 2 the tendency of respondents to mistakenly report awareness as a result of confusion between PREPs brands and similarly named familiar products, for example, Eclipse chewing gum and Accord automobiles. Conclusion After evaluating new measures with cognitive interviews, we conclude that as of winter 2006, awareness of reduced exposure products among U.S. smokers was likely to be between 1% and 8%, with the higher estimates for some products occurring in test markets. Recommended measurement strategies for future surveys are presented.

  18. Commercial introduction of the Advanced NOxTECH system

    Energy Technology Data Exchange (ETDEWEB)

    Sudduth, B.C. [NOxTECH, Inc., Irvine, CA (United States)

    1997-12-31

    NOxTECH is BACT for diesel electric generators. Emissions of NO{sub x} are reduced 95% or more with substantial concurrent reductions in CO, particulates, and ROG`s. No engine modifications or other exhaust aftertreatments can remove all criteria pollutants as effectively as NOxTECH. The NOxTECH system reliably maintains NH{sub 3} slip below 2 ppm. Unlike other emissions controls, NOxTECH does not generate hazardous by-products. The Advanced NOxTECH system reduces the size, weight, and cost for BACT emissions reductions. Based on the operation of a 150 kW prototype, NOxTECH, Inc. is quoting commercial units for diesel electric generators. Advanced NOxTECH equipment costs about half as much as SCR systems, and NO{sub x} reduction can exceed 95% with guarantees for emissions compliance.

  19. Patterns of Technological Innovation: A Comparative Analysis between Low-tech and High-tech Industries in Brazil

    Directory of Open Access Journals (Sweden)

    Raimundo Eduardo Silveira Fontenele

    2016-06-01

    Full Text Available This paper is intended to contribute to the knowledge about the patterns of innovations in different economic sectors. Hence, the general objective is to assess the differences in rates, directions, sources and efforts of innovations between low-tech and high-tech industries in Brazil. The analysis is based on the database of a survey on innovation (PINTEC conducted by IBGE. The sample includes 8,578 innovative Brazilian companies surveyed from selected low-tech industries (food and textiles manufactures and high-tech industries (vehicles and electronics industries. Descriptive and factorial correspondence analysis were used to identify the variables regarding rates, directions, sources and efforts of innovation that discriminate the low-tech industries of high-tech. The results confirm that low-tech industries differ from high tech ones in all pattern of innovations dimensions analyzed. Hence, low tech industries, compared to high-tech ones, are less innovative, innovate more in process, have fewer people dedicated to R&D, present suppliers as the most significant source of information and is a larger user of Government funding for the purchase of machinery and equipment. On the other hand, the high-tech industries are more innovative, innovate more in products, have more people dedicated to R&D, search for information of other groups of companies, customers and competitors, and their larger use of public financing is for investing in R&D.

  20. PREP-kurser for soldater, veteraner og deres partnere - en procesevaluering

    DEFF Research Database (Denmark)

    Pollmann, Jeanette Bonde; Hartmann-Madsen, Anne; Vedtofte, Mia Sadowa

    2016-01-01

    Formålet med procesevalueringen er at evaluere, hvordan implementeringen af initiativet PREP-kurser for soldater, veteraner og deres partnere er forløbet. PREP-kurserne tilbydes gratis i en projektperiode fra 2015-2017 i anerkendelsen af at udsendelser kan påvirke parforholdet og kommunikationen...... at evalueringsprocessen er hensigtsmæssig. Det kan ud fra procesevalueringen konkluderes at PREP for soldater, veteraner og deres partnere er blevet implementeret med succes, men at det bør sikres at rapportens anbefalinger implementeres. Vi anbefaler på baggrund af ovenstående at dette initiativ gøres til et permanent...... tilbud for soldater, veteraner og deres pårørende....

  1. Influence of Processing Parameters on Granularity Distribution of Superalloy Powders during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming CHEN; Benfu HU; Yiwen ZHANG; Huiying LI; Quanmao YU

    2003-01-01

    In order to investigate the influence of processing parameters on the granularity distribution of superalloy powders during the atomization of plasma rotating electrode processing (PREP), in this paper FGH95 superalloy powders is prepared under different processing conditions by PREP and the influence of PREP processing parameters on the granularity distribution of FGH95 superalloy powders is discussed based on fractal geometry theory. The results show that with the increase of rotating velocity of the self-consuming electrode, the fractal dimension of the granularity distribution increases linearly, which results in the increase of the proportion of smaller powders. The change of interval between plasma gun and the self-consuming electrode has a little effect on the granularity distribution, also the fractal dimension of the granularity distribution changed a little correspondingly.

  2. Higher Education in Further Education Colleges: Indirectly Funded Partnerships: Codes of Practice for Franchise and Consortia Arrangements. Report.

    Science.gov (United States)

    Higher Education Funding Council for England, Bristol.

    This report provides codes of practice for two types of indirectly funded partnerships entered into by higher education institutions and further education sector colleges: franchises and consortia. The codes of practice set out guidance on the principles that should be reflected in the franchise and consortia agreements that underpin indirectly…

  3. Soil-derived microbial consortia enriched with different plant biomass reveal distinct players acting in lignocellulose degradation

    NARCIS (Netherlands)

    de Lima Brossi, Maria Julia; Jiménez Avella, Diego; Cortes Tolalpa, Larisa; van Elsas, Jan

    Here, we investigated how different plant biomass, and-for one substrate-pH, drive the composition of degrader microbial consortia. We bred such consortia from forest soil, incubated along nine aerobic sequential - batch enrichments with wheat straw (WS1, pH 7.2; WS2, pH 9.0), switchgrass (SG, pH

  4. Potential Interventions to Support Adherence to HIV Preexposure Prophylaxis (PrEP): A Systematic Review

    Science.gov (United States)

    Marcus, Julia L.; Buisker, Timothy; Horvath, Tara; Amico, K. Rivet; Fuchs, Jonathan D.; Buchbinder, Susan P.; Grant, Robert M.; Liu, Albert Y.

    2014-01-01

    Objectives Adherence is critical for maximizing the effectiveness of preexposure prophylaxis (PrEP) in preventing HIV infection. Strategies for promoting adherence to HIV treatment, and their potential application to PrEP adherence, have received considerable attention. However, adherence promotion strategies for prevention medications have not been well characterized and may be more applicable to PrEP. We aimed to identify adherence support interventions that have been effective in other prevention fields and could be applied in the HIV prevention context to support pill taking among PrEP users. Methods To identify adherence support interventions that could be evaluated and applied in the PrEP context, we conducted a systematic review across the following prevention fields: hypertension, latent tuberculosis infection, hyperlipidemia, oral contraceptives, osteoporosis, malaria prophylaxis, and post-exposure prophylaxis for HIV infection. We included randomized controlled trials that evaluated the efficacy of interventions to improve adherence to daily oral medications prescribed for primary prevention in healthy individuals or for secondary prevention in asymptomatic individuals. Results Our searches identified 585 studies, of which 48 studies met the eligibility criteria and were included in the review; nine evaluated multiple strategies, yielding 64 separately tested interventions. Interventions with the strongest evidence for improving adherence included complex, resource-intensive interventions, which combined multiple adherence support approaches, and low-cost, low-intensity interventions that provided education or telephone calls for adherence support. Conclusions Our review identified adherence interventions with strong evidence of efficacy across prevention fields and provides recommendations for evaluating these interventions in upcoming PrEP studies. PMID:24580813

  5. Differentiating Criteria for High-Tech Companies

    Directory of Open Access Journals (Sweden)

    Rostek Katarzyna

    2014-12-01

    Full Text Available Manufacturing companies operating within the high-technology sector are of interest to science, industry and national authorities because of the special economic importance attached to them. However, in order to investigate the condition of those companies, support their growth and monitor the effects of the aid awarded to them, it is first necessary to properly identify the business entities belonging to that sector. To identify the entities belonging to the high-technology industry, it is necessary to perform a sequence of activities which form the procedural algorithm. Usefulness of the algorithm has been verified using the example of a group of Warsaw high-tech companies which were subject to investigation under the European project Warsaw Entrepreneurship Forum. The algorithm could be used as the basis for the implementation of an IT tool for the identification and description of high-tech businesses.

  6. Characterization of three plant biomass-degrading microbial consortia by metagenomics- and metasecretomics-based approaches

    DEFF Research Database (Denmark)

    Jiménez, Diego Javier; Brossi, Maria Julia de Lima; Schückel, Julia

    2016-01-01

    ), switchgrass (SG-M) and corn stover (CS-M) under aerobic and mesophilic conditions. Molecular fingerprintings, bacterial 16S ribosomal RNA (rRNA) gene amplicon sequencing and metagenomic analyses showed that the three microbial consortia were taxonomically distinct. Based on the taxonomic affiliation......). The highest degradation rates of lignin (~59 %) were observed with SG-M, whereas CS-M showed a high consumption of cellulose and hemicellulose. Analyses of the carbohydrate-active enzymes in the three microbial consortia showed the dominance of glycosyl hydrolases (e.g. of families GH3, GH43, GH13, GH10, GH29...

  7. Hi tech microeconomics and information nonintensive calculi

    Directory of Open Access Journals (Sweden)

    Mirko Dohnal

    2013-11-01

    Full Text Available The article establishes link between the contributions made to the study of hi tech phenomena. It analyzes the evolution undergone by studies on the topic of the knowledge economics (HI-TECH process carried out by different disciplines (hard and soft sciences – sociology, ecology etc. from the point of view of the objectives they pursue. The attentions are concentrated on analysis of applicable mathematical tools used to develop realistic formal models. Information intensity is defined as the amount of information which is needed for the realistic application of a corresponding formal tool. High information intensity is desirable because it influences the model accuracy. Low information intensity is preferred when high information intensity requires more information items than are available and this is usually the case in knowledge engineering. Fuzzy models seem to be a useful extension of formal tool used in hi tech microeconomics. However, even fuzzy sets could be prohibitively information intensive. Therefore the range of available formal tools must be considerably broader. This paper introduces qualitative and semiqualitative models and rough sets. Each formal tool is briefly characterized.

  8. Views of policymakers, healthcare workers and NGOs on HIV pre-exposure prophylaxis (PrEP): a multinational qualitative study.

    Science.gov (United States)

    Wheelock, Ana; Eisingerich, Andreas B; Gomez, Gabriela B; Gray, Emily; Dybul, Mark R; Piot, Peter

    2012-01-01

    To examine policymakers and providers' views on pre-exposure prophylaxis (PrEP) and their willingness to support its introduction, to inform policy and practice in this emerging field. Semistructured qualitative interview study. Peru, Ukraine, India, Kenya, Uganda, Botswana and South Africa. 35 policymakers, 35 healthcare workers and 21 non-governmental organisation representatives involved in HIV prevention. Six themes emerged from the data: (1) perceived HIV prevention landscape: prevention initiatives needed to be improved and expanded; (2) PrEP awareness: 50 of 91 participants had heard of PrEP; (3) benefits of PrEP: one component of the combination prevention arsenal that could help prioritise HIV prevention, empower key populations and result in economic gains; (4) challenges of PrEP: regimen complexity, cost and cost-effectiveness, risk compensation, efficacy and effectiveness, stigmatisation and criminalisation, information and training and healthcare system capacity; (5) programmatic considerations: user eligibility, communication strategy, cost, distribution, medication and HIV testing compliance and (6) early versus late implementation: participants were divided as to whether they would support an early introduction of PrEP in their country or would prefer to wait until it has been successfully implemented in other countries, with around half of those we spoke to supporting each option. Very few said they would not support PrEP at all. Despite the multiple challenges identified, there was general willingness to support the introduction of PrEP. Yet, strengthening existing HIV prevention efforts was also deemed necessary. Our results suggest that an effective PrEP programme would be delivered in healthcare facilities and involve non-governmental organisations and the community and consider the needs of mobile populations. Comprehensive information packages and training for users and providers would be critical. The cost of PrEP would be affordable and

  9. Attitudes Towards PrEP and Anticipated Condom Use Among Concordant HIV-Negative and HIV-Discordant Male Couples.

    Science.gov (United States)

    Hoff, Colleen C; Chakravarty, Deepalika; Bircher, Anja E; Campbell, Chadwick K; Grisham, Kirk; Neilands, Torsten B; Wilson, Patrick A; Dworkin, Shari

    2015-07-01

    Since the July 2012 approval by the FDA of emtricitabine/ tenofovir disoproxil fumarate (Truvada) for use as pre-exposure prophylaxis (PrEP) against HIV, its feasibility and acceptability has been under study. HIV-discordant couples are likely targets for PrEP but little is known about how this new prevention tool impacts relationships. We examined, among gay male couples, the acceptability of individual and partner use of PrEP and intentions to use condoms with primary and outside partners in the context of PrEP use. Data are from two independent samples of couples recruited in the San Francisco bay area and New York City-a qualitative one (N=48 couples) between March and November, 2011, and a quantitative one (N=171 couples) between June, 2012 and May, 2013. Data were categorized by couple HIV status and general linear models; chi-square tests of independence were used to examine condom-use intentions with primary and outside partners, by sexual risk profile, and race. Almost half of the HIV-negative couples felt PrEP was a good HIV prevention strategy for themselves and their partner. Over half reported that they would not change their current condom use if they or their partner were taking PrEP. However, approximately 30% of HIV-negative couples reported that they would stop using condoms or use them less with primary and outside partners if they were on PrEP or if their partner was on PrEP. A large percentage of couples view PrEP positively. However, to ensure safety for both partners, future programing must consider those who intend not to use condoms while on PrEP.

  10. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Directory of Open Access Journals (Sweden)

    Jae M Sevelius

    2016-10-01

    Full Text Available Introduction: Globally, transgender (“trans” women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods: Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results: To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions: In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators

  11. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Science.gov (United States)

    Sevelius, Jae M; Deutsch, Madeline B; Grant, Robert

    2016-01-01

    Introduction Globally, transgender (“trans”) women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators to uptake and

  12. Metabolic shift and electron discharge pattern of anaerobic consortia as a function of pretreatment method applied during fermentative hydrogen production

    Energy Technology Data Exchange (ETDEWEB)

    Srikanth, S.; Venkata Mohan, S.; Lalit Babu, V.; Sarma, P.N. [Bioengineering and Environmental Centre, Indian Institute of Chemical Technology, Hyderabad 500 607, AP (India)

    2010-10-15

    We have made an attempt to evaluate the variation in the electron discharge (ED) pattern of anaerobic consortia as a function of pretreatment viz., chemical, heat-shock, acid and oxygen-shock in comparison with untreated mixed consortia during fermentative hydrogen (H{sub 2}) production. Experiments were performed with dairy wastewater as substrate using anaerobic mixed consortia as biocatalyst (pretreated individually and in combination). Cyclic voltammetry (CV) elucidated significant variation in the ED pattern of mixed consortia along with H{sub 2} production and substrate degradation (SD) as a function of pretreatment method applied. Higher ED was observed with all pretreated consortia which can be attributed to the stable proton (H{sup +}) shuttling due to the suppression of methanogenic activity. Oxygen-shock method and untreated consortia showed lower H{sub 2} production and higher SD among the variations studied, while, combined pretreated consortia resulted higher H{sub 2} production and lower SD. Lower ED observed with untreated consortia suggests the H{sup +} reduction during methanogenesis rather than the inter-conversion of metabolites, which is presumed to be necessary for H{sub 2} production. ED observed with combined pretreated consortia corroborated well with the observed H{sub 2} production. Redox pairs were visualized on the voltammograms with almost all the experimental variations studied except untreated consortia. The potentials (E{sub 0}) of redox pairs observed were corresponding to intracellular electron carriers viz., NAD{sup +}/NADH (E{sub 0} -0.32 V) and FAD{sup +}/FADH{sub 2} (E{sub 0} -0.24 V). (author)

  13. I Knew I Would Be Safer. Experiences of Kenyan HIV Serodiscordant Couples Soon After Pre-Exposure Prophylaxis (PrEP) Initiation.

    Science.gov (United States)

    Ngure, Kenneth; Heffron, Renee; Curran, Kathyrn; Vusha, Sophie; Ngutu, Mariah; Mugo, Nelly; Celum, Connie; Baeten, Jared M

    2016-02-01

    Pre-exposure prophylaxis (PrEP) for HIV-uninfected persons is highly efficacious for HIV prevention. Understanding how people at risk for HIV will use PrEP is important to inform PrEP scale-up and implementation. We used qualitative methods to gather insights into couples' early experiences with PrEP use within the Partners Demonstration Project, an open-label implementation study evaluating integrated delivery of PrEP and antiretroviral therapy (ART). PrEP is offered to HIV uninfected partners until the HIV-infected partner initiates and sustains ART use (i.e., PrEP as a "bridge" to ART initiation and viral suppression). From August 2013 to March 2014 we conducted 20 in-depth dyadic interviews (n = 40) with heterosexual HIV serodiscordant couples participating at the Thika, Kenya study site, exploring how couples make decisions about using PrEP for HIV prevention. We developed and applied deductive and inductive codes to identify key themes related to experiences of PrEP initiation and use of time-limited PrEP. Couples reported that PrEP offered them an additional strategy to reduce the risk of HIV transmission, meet their fertility desires, and cope with HIV serodiscordance. Remaining HIV negative at follow-up visits reinforced couples' decisions and motivated continued adherence to PrEP. In addition, confidence in their provider's advice and client-friendly services were critical to their decisions to initiate and continue use of PrEP. Strategies for wide-scale PrEP delivery for HIV serodiscordant couples in low resource settings may include building capacity of health providers to counsel on PrEP adoption while addressing couples' concerns and barriers to adoption and continued use.

  14. The promise and peril of pre-exposure prophylaxis (PrEP): using social science to inform prep interventions among female sex workers.

    Science.gov (United States)

    Syvertsen, Jennifer L; Robertson Bazzi, Angela M; Scheibe, Andrew; Adebajo, Sylvia; Strathdee, Steffanie A; Wechsberg, Wendee M

    2014-09-01

    Advances in biomedical interventions to prevent HIV offer great promise in reducing the number of new infections across sub- Saharan Africa, particularly among vulnerable populations such as female sex workers. Several recent trials testing pre-exposure prophylaxis (PrEP) have demonstrated efficacy, although others have been stopped early for futility. Given the importance and complexities of social and behavioural factors that influence biomedical approaches to prevention, we discuss several key areas of consideration moving forward, including trial participation, adherence strategies, social relationships, and the structural factors that shape PrEP interest, use, and potential effectiveness among female sex workers in sub-Saharan Africa. Our review highlights the importance of involving social scientists in clinical and community-based research on PrEP. We advocate for a shift away from a singular "re-medicalization" of the HIV epidemic to that of a "reintegration" of interdisciplinary approaches to prevention that could benefit female sex workers and other key populations at risk of acquiring HIV.

  15. Immunological detection of enzymes for sulfate reduction in anaerobic methane-oxidizing consortia.

    Science.gov (United States)

    Milucka, Jana; Widdel, Friedrich; Shima, Seigo

    2013-05-01

    Anaerobic oxidation of methane (AOM) coupled to sulfate reduction (SR) at marine gas seeps is performed by archaeal-bacterial consortia that have so far not been cultivated in axenic binary or pure cultures. Knowledge about possible biochemical reactions in AOM consortia is based on metagenomic retrieval of genes related to those in archaeal methanogenesis and bacterial sulfate reduction, and identification of a few catabolic enzymes in protein extracts. Whereas the possible enzyme for methane activation (a variant of methyl-coenzyme M reductase, Mcr) was shown to be harboured by the archaea, enzymes for sulfate activation and reduction have not been localized so far. We adopted a novel approach of fluorescent immunolabelling on semi-thin (0.3-0.5 μm) cryosections to localize two enzymes of the SR pathway, adenylyl : sulfate transferase (Sat; ATP sulfurylase) and dissimilatory sulfite reductase (Dsr) in microbial consortia from Black Sea methane seeps. Both Sat and Dsr were exclusively found in an abundant microbial morphotype (c. 50% of all cells), which was tentatively identified as Desulfosarcina/Desulfococcus-related bacteria. These results show that ANME-2 archaea in the Black Sea AOM consortia did not express bacterial enzymes of the canonical sulfate reduction pathway and thus, in contrast to previous suggestions, most likely cannot perform canonical sulfate reduction. Moreover, our results show that fluorescent immunolabelling on semi-thin cryosections which to our knowledge has been so far only applied on cell tissues, is a powerful tool for intracellular protein detection in natural microbial associations.

  16. Comparison of prominent Azospirillum strains in Azospirillum-Pseudomonas-Glomus consortia for promotion of maize growth.

    Science.gov (United States)

    Couillerot, Olivier; Ramírez-Trujillo, Augusto; Walker, Vincent; von Felten, Andreas; Jansa, Jan; Maurhofer, Monika; Défago, Geneviève; Prigent-Combaret, Claire; Comte, Gilles; Caballero-Mellado, Jesus; Moënne-Loccoz, Yvan

    2013-05-01

    Azospirillum are prominent plant growth-promoting rhizobacteria (PGPR) extensively used as phytostimulatory crop inoculants, but only few studies are dealing with Azospirillum-containing mixed inocula involving more than two microorganisms. We compared here three prominent Azospirillum strains as part of three-component consortia including also the PGPR Pseudomonas fluorescens F113 and a mycorrhizal inoculant mix composed of three Glomus strains. Inoculant colonization of maize was assessed by quantitative PCR, transcription of auxin synthesis gene ipdC (involved in phytostimulation) in Azospirillum by RT-PCR, and effects on maize by secondary metabolic profiling and shoot biomass measurements. Results showed that phytostimulation by all the three-component consortia was comparable, despite contrasted survival of the Azospirillum strains and different secondary metabolic responses of maize to inoculation. Unexpectedly, the presence of Azospirillum in the inoculum resulted in lower phytostimulation in comparison with the Pseudomonas-Glomus two-component consortium, but this effect was transient. Azospirillum's ipdC gene was transcribed in all treatments, especially with three-component consortia, but not with all plants and samplings. Inoculation had no negative impact on the prevalence of mycorrhizal taxa in roots. In conclusion, this study brought new insights in the functioning of microbial consortia and showed that Azospirillum-Pseudomonas-Glomus three-component inoculants may be useful in environmental biotechnology for maize growth promotion.

  17. CO2 sequestration by ureolytic microbial consortia through microbially-induced calcite precipitation.

    Science.gov (United States)

    Okyay, Tugba O; Nguyen, Hang N; Castro, Sarah L; Rodrigues, Debora F

    2016-12-01

    Urea is an abundant nitrogen-containing compound found in urine of mammals and widely used in fertilizers. This compound is part of the nitrogen biogeochemical cycle and is easily biodegraded by ureolytic microorganisms that have the urease enzyme. Previous studies, with ureolytic isolates, have shown that some ureolytic microorganisms are able to sequester CO2 through a process called microbially-induced calcium carbonate precipitation. The present study investigates 15 ureolytic consortia obtained from the "Pamukkale travertines" and the "Cave Without A Name" using different growth media to identify the possible bacterial genera responsible for CO2 sequestration through the microbially-induced calcite precipitation (MICP). The community structure and diversity were determined by deep-sequencing. The results showed that all consortia presented varying CO2 sequestration capabilities and MICP rates. The CO2 sequestration varied between 0 and 86.4%, and it depended largely on the community structure, as well as on pH. Consortia with predominance of Comamonas, Plesiomonas and Oxalobacter presented reduced CO2 sequestration. On the other hand, consortia dominated by Sporosarcina, Sphingobacterium, Stenotrophomonas, Acinetobacter, and Elizabethkingia showed higher rates of CO2 uptake in the serum bottle headspace.

  18. Metataxonomic profiling and prediction of functional behaviour of wheat straw degrading microbial consortia

    NARCIS (Netherlands)

    Jiménez Avella, Diego; Dini Andreote, Francisco; van Elsas, Jan Dirk

    2014-01-01

    Background: Mixed microbial cultures, in which bacteria and fungi interact, have been proposed as an efficient way to deconstruct plant waste. The characterization of specific microbial consortia could be the starting point for novel biotechnological applications related to the efficient conversion

  19. Characterization of three plant biomass-degrading microbial consortia by metagenomics- and metasecretomics-based approaches

    NARCIS (Netherlands)

    Jiménez, Diego Javier; Brossi, Maria Julia de Lima; Schuckel, Julia; Kracun, Stjepan Kresimir; Willats, William George Tycho; van Elsas, Jan Dirk

    2016-01-01

    The selection of microbes by enrichment on plant biomass has been proposed as an efficient way to develop new strategies for lignocellulose saccharification. Here, we report an in-depth analysis of soil-derived microbial consortia that were trained to degrade once-used wheat straw (WS1-M),

  20. Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience

    Science.gov (United States)

    Bennett, Siiri N.; Caporaso, Neil; Fitzpatrick, Annette L.; Agrawal, Arpana; Barnes, Kathleen; Boyd, Heather A.; Cornelis, Marilyn C.; Hansel, Nadia N.; Heiss, Gerardo; Heit, John A.; Kang, Jae Hee; Kittner, Steven J.; Kraft, Peter; Lowe, William; Marazita, Mary L.; Monroe, Kristine R.; Pasquale, Louis R.; Ramos, Erin M.; van Dam, Rob M.; Udren, Jenna; Williams, Kayleen

    2011-01-01

    Genome-wide association study (GWAS) consortia and collaborations formed to detect genetic loci for common phenotypes or investigate gene-environment (G*E) interactions are increasingly common. While these consortia effectively increase sample size, phenotype heterogeneity across studies represents a major obstacle that limits successful identification of these associations. Investigators are faced with the challenge of how to harmonize previously collected phenotype data obtained using different data collection instruments which cover topics in varying degrees of detail and over diverse time frames. This process has not been described in detail. We describe here some of the strategies and pitfalls associated with combining phenotype data from varying studies. Using the Gene Environment Association Studies (GENEVA) multi-site GWAS consortium as an example, this paper provides an illustration to guide GWAS consortia through the process of phenotype harmonization and describes key issues that arise when sharing data across disparate studies. GENEVA is unusual in the diversity of disease endpoints and so the issues it faces as its participating studies share data will be informative for many collaborations. Phenotype harmonization requires identifying common phenotypes, determining the feasibility of cross-study analysis for each, preparing common definitions, and applying appropriate algorithms. Other issues to be considered include genotyping timeframes, coordination of parallel efforts by other collaborative groups, analytic approaches, and imputation of genotype data. GENEVA's harmonization efforts and policy of promoting data sharing and collaboration, not only within GENEVA but also with outside collaborations, can provide important guidance to ongoing and new consortia. PMID:21284036

  1. 76 FR 17391 - Applications for New Awards; United States-Brazil Higher Education Consortia Program

    Science.gov (United States)

    2011-03-29

    ... Applications for New Awards; United States-Brazil Higher Education Consortia Program AGENCY: Office of... Postsecondary Education (FIPSE)--Special Focus Competition: United States (U.S.)- Brazil Higher Education... institution of higher education (IHE) in another country in Latin America (in addition to Brazil) to create...

  2. Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw

    NARCIS (Netherlands)

    Jiménez Avella, Diego; Chaves-Moreno, Diego; van Elsas, Jan Dirk

    2015-01-01

    Based on the premise that plant biomass can be efficiently degraded by mixed microbial cultures and/or enzymes, we here applied a targeted metagenomics-based approach to explore the metabolic potential of two forest soil-derived lignocellulolytic microbial consortia, denoted RWS and TWS (bred on

  3. Construction of PAH-degrading mixed microbial consortia by induced selection in soil.

    Science.gov (United States)

    Zafra, German; Absalón, Ángel E; Anducho-Reyes, Miguel Ángel; Fernandez, Francisco J; Cortés-Espinosa, Diana V

    2017-04-01

    Bioremediation of polycyclic aromatic hydrocarbons (PAHs)-contaminated soils through the biostimulation and bioaugmentation processes can be a strategy for the clean-up of oil spills and environmental accidents. In this work, an induced microbial selection method using PAH-polluted soils was successfully used to construct two microbial consortia exhibiting high degradation levels of low and high molecular weight PAHs. Six fungal and seven bacterial native strains were used to construct mixed consortia with the ability to tolerate high amounts of phenanthrene (Phe), pyrene (Pyr) and benzo(a)pyrene (BaP) and utilize these compounds as a sole carbon source. In addition, we used two engineered PAH-degrading fungal strains producing heterologous ligninolytic enzymes. After a previous selection using microbial antagonism tests, the selection was performed in microcosm systems and monitored using PCR-DGGE, CO2 evolution and PAH quantitation. The resulting consortia (i.e., C1 and C2) were able to degrade up to 92% of Phe, 64% of Pyr and 65% of BaP out of 1000 mg kg(-1) of a mixture of Phe, Pyr and BaP (1:1:1) after a two-week incubation. The results indicate that constructed microbial consortia have high potential for soil bioremediation by bioaugmentation and biostimulation and may be effective for the treatment of sites polluted with PAHs due to their elevated tolerance to aromatic compounds, their capacity to utilize them as energy source.

  4. Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience.

    Science.gov (United States)

    Bennett, Siiri N; Caporaso, Neil; Fitzpatrick, Annette L; Agrawal, Arpana; Barnes, Kathleen; Boyd, Heather A; Cornelis, Marilyn C; Hansel, Nadia N; Heiss, Gerardo; Heit, John A; Kang, Jae Hee; Kittner, Steven J; Kraft, Peter; Lowe, William; Marazita, Mary L; Monroe, Kristine R; Pasquale, Louis R; Ramos, Erin M; van Dam, Rob M; Udren, Jenna; Williams, Kayleen

    2011-04-01

    Genome-wide association study (GWAS) consortia and collaborations formed to detect genetic loci for common phenotypes or investigate gene-environment (G*E) interactions are increasingly common. While these consortia effectively increase sample size, phenotype heterogeneity across studies represents a major obstacle that limits successful identification of these associations. Investigators are faced with the challenge of how to harmonize previously collected phenotype data obtained using different data collection instruments which cover topics in varying degrees of detail and over diverse time frames. This process has not been described in detail. We describe here some of the strategies and pitfalls associated with combining phenotype data from varying studies. Using the Gene Environment Association Studies (GENEVA) multi-site GWAS consortium as an example, this paper provides an illustration to guide GWAS consortia through the process of phenotype harmonization and describes key issues that arise when sharing data across disparate studies. GENEVA is unusual in the diversity of disease endpoints and so the issues it faces as its participating studies share data will be informative for many collaborations. Phenotype harmonization requires identifying common phenotypes, determining the feasibility of cross-study analysis for each, preparing common definitions, and applying appropriate algorithms. Other issues to be considered include genotyping timeframes, coordination of parallel efforts by other collaborative groups, analytic approaches, and imputation of genotype data. GENEVA's harmonization efforts and policy of promoting data sharing and collaboration, not only within GENEVA but also with outside collaborations, can provide important guidance to ongoing and new consortia.

  5. Metataxonomic profiling and prediction of functional behaviour of wheat straw degrading microbial consortia

    NARCIS (Netherlands)

    Jiménez Avella, Diego; Dini Andreote, Francisco; van Elsas, Jan Dirk

    2014-01-01

    Background: Mixed microbial cultures, in which bacteria and fungi interact, have been proposed as an efficient way to deconstruct plant waste. The characterization of specific microbial consortia could be the starting point for novel biotechnological applications related to the efficient conversion

  6. Novel multispecies microbial consortia involved in lignocellulose and 5-hydroxymethylfurfural bioconversion

    NARCIS (Netherlands)

    Jiménez Avella, Diego; Korenblum, Elisa; van Elsas, Jan Dirk

    2014-01-01

    To develop a targeted metagenomics approach for the analysis of novel multispecies microbial consortia involved in the bioconversion of lignocellulose and furanic compounds, we applied replicated sequential batch aerobic enrichment cultures with either pretreated or untreated wheat straw as the sour

  7. Summer Professional Development in Chemistry for Inservice Teachers Using OWL Quick Prep

    Science.gov (United States)

    Powell, Cynthia B.; Pamplin, Kim L.; Blake, Robert E.; Mason, Diana S.

    2010-01-01

    Secondary teachers participating in summer professional development chemistry workshops in Texas used an online chemistry tutoring program, OWL Quick Prep (Day et al. in OWL: Online Web-based Learning, Brooks-Cole Cengage Learning, Florence, KY, 1997) as a part of the inservice training. Self-reported demographic data were used to identify factors…

  8. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  9. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  10. Quality improvement: single-field sterile scrub, prep, and dwell for laparoscopic hysterectomy.

    Science.gov (United States)

    O'Hanlan, Katherine A; McCutcheon, Stacey Paris; McCutcheon, John G; Charvonia, Beth E

    2013-05-01

    The vulva and vaginal interior are considered a contaminated surgical area, and current OR guidelines require surgeons who are gloved and gowned at the abdominal field to avoid contact with the urethral catheter, the uterine manipulator, and the introitus or to change their gloves and even regown if contact occurs. It is our belief that the perception of the vaginal field as contaminated reflects a lack of specific standards for the preoperative cleansing of the deeper vagina and a lack of preoperative prep instructions for the combined fields. We developed a comprehensive single-field prep technique designed to improve surgical efficiency and prevent contamination of the sterile field. Combining a methodical scrub, prep, and dwell, this technique allows the entire abdomino-perineovaginal field to be treated as a single sterile field for laparoscopic procedures. Our surgical site infection rate of 1.8% when using this single-field prep technique and the subsequent surgical treatment of the abdominal, vaginal, and perineal fields as a single sterile field is well within reported norms.

  11. Moving beyond Test-Prep Pedagogy: Dialoguing with Multicultural Preservice Teachers for a Quality Education

    Science.gov (United States)

    Rodríguez, Louie F.

    2013-01-01

    In a "post-NCLB era," the schooling experiences of mostly low-income students of color continue to be consumed by a test-prep pedagogy--narrowed curriculum, low expectations, and ignored relationships. In this article the author describes a pedagogical approach using educational dialogues to engage preservice teachers to critically…

  12. Consortia Focused on Photovoltaic R&D, Manufacturing, and Testing: A Review of Existing Models and Structures

    Energy Technology Data Exchange (ETDEWEB)

    Coggeshall, C.; Margolis, R. M.

    2010-03-01

    As the U.S. Department of Energy's (DOE's) Solar Energy Technologies Program prepares to initiate a new cost-shared research and development (R&D) effort on photovoltaic (PV) manufacturing, it is useful to review the experience to date with consortia focused on PV R&D, manufacturing, and testing. Information was gathered for this report by conducting interviews and accessing Web sites of 14 U.S. consortia and four European consortia, each with either a primary focus on or an emerging interest in PV technology R&D, manufacturing, or testing. Additional input was collected from several workshops held by the DOE and National Academy of Sciences (NAS) in 2009, which examined the practical steps -- including public-private partnerships and policy support -- necessary to enhance the United States' capacity to competitively manufacture photovoltaics. This report categorizes the 18 consortia into three groups: university-led consortia, industry-led consortia, and manufacturing and testing facilities consortia. The first section summarizes the organizations within the different categories, with a particular focus on the key benefits and challenges for each grouping. The second section provides a more detailed overview of each consortium, including the origins, goals, organization, membership, funding sources, and key contacts. This survey is a useful resource for stakeholders interested in PV manufacturing R&D, but should not imply endorsement of any of these groups.

  13. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users.

    Science.gov (United States)

    Shrestha, Roman; Karki, Pramila; Altice, Frederick L; Dubov, Oleksandr; Fraenkel, Liana; Huedo-Medina, Tania; Copenhaver, Michael

    2017-07-10

    Although people who use drugs (PWUD) are one of the key risk populations who could benefit from the use of pre-exposure prophylaxis (PrEP), to date, little attention has been given to incorporating PrEP into HIV prevention approaches targeting this underserved group. This study investigated the acceptability of PrEP based on a number of known PrEP attributes among high-risk PWUD in a drug treatment setting. A total of 400 HIV-negative PWUD, who reported drug- and/or sex-related risk behaviors were recruited from a methadone clinic to complete a stated preference (full-profile conjoint) survey. Participants ranked the eight hypothetical PrEP program scenarios with varied combinations of six attributes related to PrEP (cost, dosing, efficacy, side-effects, treatment setting, and frequency of HIV testing). SPSS conjoint procedure was used to estimate the relative importance of each attribute and preferences across eight possible PrEP delivery programs. PrEP acceptability ranged from 30.6 to 86.3% with a mean acceptability of 56.2% across the eight hypothetical PrEP program scenarios. The PrEP program scenario with the highest acceptability had the following attribute levels: insurance covered, daily dosing, 95% effective, no side-effects, treatment at HIV clinic, and HIV testing needed every 6 months. The cost associated with PrEP was the most important attribute (relative importance score: RIS = 38.8), followed by efficacy (RIS = 20.5) and side effects (RIS = 11.9); other attributes had no significant effect. Our findings reported a high acceptability of PrEP in response to different PrEP program scenarios with different attribute profiles. As the result of having this information, researchers and policymakers will be better equipped for evidence informed targeting and dissemination efforts to optimize PrEP uptake among this underserved population.

  14. Polycyclic aromatic hydrocarbons (PAHs) biodegradation potential and diversity of microbial consortia enriched from tsunami sediments in Miyagi, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Bacosa, Hernando Pactao, E-mail: hernando.bacosa@utexas.edu [Graduate School of Environmental Studies, Tohoku University, Aoba 6-6-20, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Marine Science Institute, The University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373 (United States); Inoue, Chihiro [Graduate School of Environmental Studies, Tohoku University, Aoba 6-6-20, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

    2015-02-11

    Highlights: • Most bacterial consortia from tsunami sediment degraded PAH mixture and pyrene. • The consortia were dominated by known and unknown PAHs-degrading bacteria. • Dokdonella clone is a potential new species and PAH degrader from tsunami sediment. • PAH-RHDα is better than nidA gene for estimating pyrene-degraders in the consortia. • First report on the PAH degradation and PAH-degrading bacteria from tsunami sediment. - Abstract: The Great East Japan Earthquake caused tsunamis and resulted in widespread damage to human life and infrastructure. The disaster also resulted in contamination of the environment by chemicals such as polycyclic aromatic hydrocarbons (PAHs). This study was conducted to investigate the degradation potential and describe the PAH-degrading microbial communities from tsunami sediments in Miyagi, Japan. PAH-degrading bacteria were cultured by enrichment using PAH mixture or pyrene alone as carbon and energy sources. Among the ten consortia tested for PAH mixture, seven completely degraded fluorene and more than 95% of phenanthrene in 10 days, while only four consortia partially degraded pyrene. Six consortia partially degraded pyrene as a single substrate. Polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) revealed that each sample was dominated by unique microbial populations, regardless of sampling location. The consortia were dominated by known PAHs degraders including Sphingomonas, Pseudomonas, and Sphingobium; and previously unknown degraders such as Dokdonella and Luteimonas. A potentially novel and PAH-degrading Dokdonella was detected for the first time. PAH-ring hydroxylating dioxygenase (PAH-RHDα) gene was shown to be more effective than nidA in estimating pyrene-degrading bacteria in the enriched consortia. The consortia obtained in this study are potential candidates for remediation of PAHs contaminated soils.

  15. High Energy Physics Research at Louisiana Tech

    Energy Technology Data Exchange (ETDEWEB)

    Sawyer, Lee [Louisiana State Univ., Baton Rouge, LA (United States); Greenwood, Zeno [Louisiana State Univ., Baton Rouge, LA (United States); Wobisch, Marcus [Louisiana State Univ., Baton Rouge, LA (United States)

    2013-06-28

    The goal of this project was to create, maintain, and strengthen a world-class, nationally and internationally recognized experimental high energy physics group at Louisiana Tech University, focusing on research at the energy frontier of collider-based particle physics, first on the DØ experiment and then with the ATLAS experiment, and providing leadership within the US high energy physics community in the areas of jet physics, top quark and charged Higgs decays involving tau leptons, as well as developing leadership in high performance computing.

  16. AARP iPad Tech to Connect

    CERN Document Server

    Boyd, Barbara

    2012-01-01

    The world is at your fingertips with iPad! AARP iPad: Tech to Connect introduces you to the world?s most popular tablet device, the iPad, and all the amazing things it has to offer. In clear, non-technical language, this book guides you through registering and setting up your iPad, getting acquainted with the multitouch interface, navigating around the screen, finding and downloading apps, reading books, listening to music, watching videos, surfing the web, and communicating with friends and family. Developed in partnership with AARP and dedicated to helping readers stay connected with friends

  17. FinTech Market Development Perspectives

    OpenAIRE

    Kalmykova Ekaterina; Ryabova Anna

    2016-01-01

    Fast development of technologies has led to emergence of the new market – FinTech – which is very attractive for investors today. By now this market has a great number of different concepts: P2P-crediting, E-wallets, Bitcoins, mPOS-acquiring, T-commerce, mobile banks, etc. Many of these tools have already heavily entered our ordinary life. People can obtain any credits through special services on the Internet from other users without participation of banks, pay by credit card using mobile dev...

  18. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Science.gov (United States)

    Ravasi, Giovanni; Grinsztejn, Beatriz; Baruch, Ricardo; Guanira, Juan Vicente; Luque, Ricardo; Cáceres, Carlos F; Ghidinelli, Massimo

    2016-01-01

    Introduction Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP) is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint negotiation and

  19. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Directory of Open Access Journals (Sweden)

    Giovanni Ravasi

    2016-10-01

    Full Text Available Introduction: Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion: Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint

  20. TechTrends 2010-2015: A Content Analysis

    Science.gov (United States)

    Stauffer, Eric

    2017-01-01

    This study is a content analysis of articles published within the journal "TechTrends" from 2000 to 2015. The study reveals that the publication "TechTrends" has increased the overall number of peer reviewed original papers over the last 6 years. The author describes the proportion of these original papers per volume and…

  1. Georgia tech catalog of gravitational waveforms

    Science.gov (United States)

    Jani, Karan; Healy, James; Clark, James A.; London, Lionel; Laguna, Pablo; Shoemaker, Deirdre

    2016-10-01

    This paper introduces a catalog of gravitational waveforms from the bank of simulations by the numerical relativity effort at Georgia Tech. Currently, the catalog consists of 452 distinct waveforms from more than 600 binary black hole simulations: 128 of the waveforms are from binaries with black hole spins aligned with the orbital angular momentum, and 324 are from precessing binary black hole systems. The waveforms from binaries with non-spinning black holes have mass-ratios q = m 1/m 2 ≤ 15, and those with precessing, spinning black holes have q ≤ 8. The waveforms expand a moderate number of orbits in the late inspiral, the burst during coalescence, and the ring-down of the final black hole. Examples of waveforms in the catalog matched against the widely used approximate models are presented. In addition, predictions of the mass and spin of the final black hole by phenomenological fits are tested against the results from the simulation bank. The role of the catalog in interpreting the GW150914 event and future massive binary black-hole search in LIGO is discussed. The Georgia Tech catalog is publicly available at einstein.gatech.edu/catalog.

  2. TechEdSat Nano-Satellite Series Fact Sheet

    Science.gov (United States)

    Murbach, Marcus; Martinez, Andres; Guarneros Luna, Ali

    2014-01-01

    TechEdSat-3p is the second generation in the TechEdSat-X series. The TechEdSat Series uses the CubeSat standards established by the California Polytechnic State University Cal Poly), San Luis Obispo. With typical blocks being constructed from 1-unit (1U 10x10x10 cm) increments, the TechEdSat-3p has a 3U volume with a 30 cm length. The project uniquely pairs advanced university students with NASA researchers in a rapid design-to-flight experience lasting 1-2 semesters.The TechEdSat Nano-Satellite Series provides a rapid platform for testing technologies for future NASA Earth and planetary missions, as well as providing students with an early exposure to flight hardware development and management.

  3. Tailored combination prevention packages and PrEP for young key populations

    Directory of Open Access Journals (Sweden)

    Audrey Pettifor

    2015-02-01

    Full Text Available Introduction: Young key populations, defined in this article as men who have sex with men, transgender persons, people who sell sex and people who inject drugs, are at particularly high risk for HIV. Due to the often marginalized and sometimes criminalized status of young people who identify as members of key populations, there is a need for HIV prevention packages that account for the unique and challenging circumstances they face. Pre-exposure prophylaxis (PrEP is likely to become an important element of combination prevention for many young key populations. Objective: In this paper, we discuss important challenges to HIV prevention among young key populations, identify key components of a tailored combination prevention package for this population and examine the role of PrEP in these prevention packages. Methods: We conducted a comprehensive review of the evidence to date on prevention strategies, challenges to prevention and combination prevention packages for young key populations. We focused specifically on the role of PrEP in these prevention packages and on young people under the age of 24, and 18 in particular. Results and discussion: Combination prevention packages that include effective, acceptable and scalable behavioural, structural and biologic interventions are needed for all key populations to prevent new HIV infections. Interventions in these packages should meaningfully involve beneficiaries in the design and implementation of the intervention, and take into account the context in which the intervention is being delivered to thoughtfully address issues of stigma and discrimination. These interventions will likely be most effective if implemented in conjunction with strategies to facilitate an enabling environment, including increasing access to HIV testing and health services for PrEP and other prevention strategies, decriminalizing key populations’ practices, increasing access to prevention and care, reducing stigma and

  4. PreP+07: improvements of a user friendly tool to preprocess and analyse microarray data

    Directory of Open Access Journals (Sweden)

    Claros M Gonzalo

    2009-01-01

    Full Text Available Abstract Background Nowadays, microarray gene expression analysis is a widely used technology that scientists handle but whose final interpretation usually requires the participation of a specialist. The need for this participation is due to the requirement of some background in statistics that most users lack or have a very vague notion of. Moreover, programming skills could also be essential to analyse these data. An interactive, easy to use application seems therefore necessary to help researchers to extract full information from data and analyse them in a simple, powerful and confident way. Results PreP+07 is a standalone Windows XP application that presents a friendly interface for spot filtration, inter- and intra-slide normalization, duplicate resolution, dye-swapping, error removal and statistical analyses. Additionally, it contains two unique implementation of the procedures – double scan and Supervised Lowess-, a complete set of graphical representations – MA plot, RG plot, QQ plot, PP plot, PN plot – and can deal with many data formats, such as tabulated text, GenePix GPR and ArrayPRO. PreP+07 performance has been compared with the equivalent functions in Bioconductor using a tomato chip with 13056 spots. The number of differentially expressed genes considering p-values coming from the PreP+07 and Bioconductor Limma packages were statistically identical when the data set was only normalized; however, a slight variability was appreciated when the data was both normalized and scaled. Conclusion PreP+07 implementation provides a high degree of freedom in selecting and organizing a small set of widely used data processing protocols, and can handle many data formats. Its reliability has been proven so that a laboratory researcher can afford a statistical pre-processing of his/her microarray results and obtain a list of differentially expressed genes using PreP+07 without any programming skills. All of this gives support to scientists

  5. Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.

    Science.gov (United States)

    Risolino, Maurizio; Mandia, Nadia; Iavarone, Francescopaolo; Dardaei, Leila; Longobardi, Elena; Fernandez, Serena; Talotta, Francesco; Bianchi, Fabrizio; Pisati, Federica; Spaggiari, Lorenzo; Harter, Patrick N; Mittelbronn, Michel; Schulte, Dorothea; Incoronato, Mariarosaria; Di Fiore, Pier Paolo; Blasi, Francesco; Verde, Pasquale

    2014-09-01

    Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis. Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplastic transformation by competing with myeloid ecotropic integration site 1 for binding to the common heterodimeric partner Pbx1. Epithelial-mesenchymal transition (EMT) is controlled by complex networks of proinvasive transcription factors responsive to paracrine factors such as TGF-β. Here we show that, in addition to inhibiting primary tumor growth, PREP1 is a novel EMT inducer and prometastatic transcription factor. In human non-small cell lung cancer (NSCLC) cells, PREP1 overexpression is sufficient to trigger EMT, whereas PREP1 down-regulation inhibits the induction of EMT in response to TGF-β. PREP1 modulates the cellular sensitivity to TGF-β by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation through mechanisms dependent, at least in part, on PREP1-mediated transactivation of a regulatory element in the SMAD3 first intron. Along with the stabilization and accumulation of PBX1, PREP1 induces the expression of multiple activator protein 1 components including the proinvasive Fos-related antigen 1 (FRA-1) oncoprotein. Both FRA-1 and PBX1 are required for the mesenchymal changes triggered by PREP1 in lung tumor cells. Finally, we show that the PREP1-induced mesenchymal transformation correlates with significantly increased lung colonization by cells overexpressing PREP1. Accordingly, we have detected PREP1 accumulation in a large number of human brain metastases of various solid tumors, including NSCLC. These findings point to a novel role of the PREP1 homeoprotein in the control of the TGF-β pathway, EMT, and metastasis in NSCLC.

  6. "Support Your Client at the Space That They're in": HIV Pre-Exposure Prophylaxis (PrEP) Prescribers' Perspectives on PrEP-Related Risk Compensation.

    Science.gov (United States)

    Calabrese, Sarah K; Magnus, Manya; Mayer, Kenneth H; Krakower, Douglas S; Eldahan, Adam I; Hawkins, Lauren A Gaston; Underhill, Kristen; Hansen, Nathan B; Kershaw, Trace S; Betancourt, Joseph R; Dovidio, John F

    2017-04-01

    Despite the demonstrated effectiveness of HIV pre-exposure prophylaxis (PrEP) and evidence that most PrEP users do not engage in risk compensation (i.e., increased risk behavior due to a perceived decrease in HIV susceptibility), some healthcare providers report patient risk compensation to be a deterrent to prescribing PrEP. Overcoming this barrier is essential to supporting PrEP access and uptake among people at risk for HIV. To inform such efforts, this qualitative study explored PrEP-related risk compensation attitudes among providers with firsthand experience prescribing PrEP. US-based PrEP providers (n = 18), most of whom were HIV specialists, were recruited through direct outreach and referral from colleagues and other participants. Individual 90-min semistructured interviews were conducted by phone or in person from September 2014 through February 2015, transcribed, and thematically analyzed. Three attitudinal themes emerged: (1) providers' role is to support patients in making informed decisions, (2) risk behavior while taking PrEP does not fully offset PrEP's protective benefit (i.e., PrEP confers net protection, even with added behavioral risk), and (3) PrEP-related risk compensation is unduly stigmatized within and beyond the healthcare community. Participants were critical of other healthcare providers' negative judgment of patients and reluctance to prescribe PrEP due to anticipated risk compensation. Several providers also acknowledged an evolution in their thinking from initial ambivalence toward greater acceptance of PrEP and PrEP-related behavior change. PrEP providers' insights about risk compensation may help to address unsubstantiated concerns about PrEP-related risk compensation and challenge the acceptability of withholding PrEP on these grounds.

  7. Are we PREPared? Quality of information available to patients in the UK about PREP on the internet

    Directory of Open Access Journals (Sweden)

    S Duncan

    2012-11-01

    Full Text Available Professional bodies in the UK (BASHH/BHIVA do not currently recommended pre-exposure prophylaxis (PREP to prevent HIV aquisition for men who have sex with men (MSM [1]. Conversely, although Federal Drug Administration approval is awaited, the Centers for Disease Control (CDC have issued clinicians in the USA with interim guidance to facilitate PREP prescriptions [2]. Increasingly patients search the internet for information on HIV treatment, but disparate international policy can lead to confusing patient messages. This study was conducted to systematically assess the quality of internet information available to patients in the UK about PREP. More than 90% of internet searches in the UK are performed using ‘Google.co.uk’ and ‘Bing’ [3]. Using pre-specified criteria, we reviewed the first 100 hits retrieved from each search engine when the following searches were performed: [“HIV pre-exposure prophylaxis”]; [“HIV PREP”]; [“HIV PREP guidelines”]; [“HIV PREP guidelines UK”]; [“truvada prophylaxis HIV”]. Of 172 unique websites identified, 124 websites were active at the time of the review (July 2012. 33 websites were links to academic journals including commentaries and clinical trials, not intended to specifically provide patient information; 5 were internet portals directing users to alternative sites and 10 websites contained no information about PREP. Of the remaining 76 websites, 28 were written by medical professionals and 48 were written by journalists, where 7/48 (15% were individual blogs. 64/76 (84% contained a definition of PREP; 63/76 (83% discussed the rationale and 58/76 (76% reported efficacy data. Advantages and disadvantages of PREP were presented in 56/76 (74% and 41/76 (54% of websites respectively. Only 21/76 (28% of sites referenced existing national guidelines (CDC/BASHH. A minority of sites described the current clinical practice in the UK (7/76, 9% with an even smaller number presenting the

  8. Are Thai MSM willing to take PrEP for HIV prevention? An analysis of attitudes, preferences and acceptance.

    Directory of Open Access Journals (Sweden)

    Ana Wheelock

    Full Text Available OBJECTIVE: We aimed to understand the attitudes, preferences and acceptance of oral and parenteral PrEP among men who have sex with men (MSM in Thailand. BACKGROUND: Pre-exposure prophylaxis (PrEP, the use of antiretrovirals to prevent HIV acquisition, has shown promising results in recent trials. To assess the potential impact of this new HIV prevention method, in addition to efficacy data, we need to understand which psychosocial factors are likely to determine its uptake among members of potential user groups. METHODS AND FINDINGS: Surveys of willingness to use PrEP products were administered to MSM. Spearman's rank tests were used to uncover associations between questionnaire items. Mann-Whitney tests were performed to ascertain differences between groups. Conjoint analysis was used to examine the attitudes and preferences of MSM towards PrEP attributes. Most participants were willing to consider taking PrEP (39.2% "yes, definitely" and 49.2% "yes, probably" and perceived PrEP as giving them new possibilities in their lives (38.5% "a lot of hope" and 55.8% "some hope", even after being instructed of potential side effects and costs. HIV testing was considered the most important attribute and a daily pill and longer lasting injection in the arm were the preferred routes of administration. CONCLUSIONS: Despite its multiple challenges, MSM in Thailand would be willing to take PrEP, even if they had to experience inconvenience and expense. If PrEP were to be implemented in Thailand, our findings show that its uptake could be considerable.

  9. Enhanced methane production via repeated batch bioaugmentation pattern of enriched microbial consortia.

    Science.gov (United States)

    Yang, Zhiman; Guo, Rongbo; Xu, Xiaohui; Wang, Lin; Dai, Meng

    2016-09-01

    Using batch and repeated batch cultivations, this study investigated the effects of bioaugmentation with enriched microbial consortia (named as EMC) on methane production from effluents of hydrogen-producing stage of potato slurry, as well as on the indigenous bacterial community. The results demonstrated that the improved methane production and shift of the indigenous bacterial community structure were dependent on the EMC/sludge ratio and bioaugmentation patterns. The methane yield and production rate in repeated batch bioaugmentation pattern of EMC were, respectively, average 15% and 10% higher than in one-time bioaugmentation pattern of EMC. DNA-sequencing approach showed that the enhanced methane production in the repeated batch bioaugmentation pattern of EMC mainly resulted from the enriched iron-reducing bacteria and the persistence of the introduced Syntrophomonas, which led to a rapid degradation of individual VFAs to methane. The findings contributed to understanding the correlation between the bioaugmentation of microbial consortia, community shift, and methane production.

  10. The E-rate Program and Libraries and Library Consortia, 2000-2004: Trends and Issues

    Directory of Open Access Journals (Sweden)

    Paul T. Jaeger

    2005-06-01

    Full Text Available The E-rate program has provided tremendous benefits to libraries, allowing many libraries and library systems to acquire technological equipment and services that would otherwise be too expensive, increasing the availability of public Internet access through libraries. This article analyzes the data related to the E-rate program and the discounts that it has provided to libraries and library systems between 2000 and 2004. By examining the E-rate data in a longitudinal manner, this article explores the trends in the application for and the provision of E-rate discounts to libraries and library consortia at national and state levels. The data suggest that, despite a number of controversies over the years, the program has provided a significant level of support for libraries and library consortia.

  11. Polycyclic aromatic hydrocarbons (PAHs) biodegradation potential and diversity of microbial consortia enriched from tsunami sediments in Miyagi, Japan.

    Science.gov (United States)

    Bacosa, Hernando Pactao; Inoue, Chihiro

    2015-01-01

    The Great East Japan Earthquake caused tsunamis and resulted in widespread damage to human life and infrastructure. The disaster also resulted in contamination of the environment by chemicals such as polycyclic aromatic hydrocarbons (PAHs). This study was conducted to investigate the degradation potential and describe the PAH-degrading microbial communities from tsunami sediments in Miyagi, Japan. PAH-degrading bacteria were cultured by enrichment using PAH mixture or pyrene alone as carbon and energy sources. Among the ten consortia tested for PAH mixture, seven completely degraded fluorene and more than 95% of phenanthrene in 10 days, while only four consortia partially degraded pyrene. Six consortia partially degraded pyrene as a single substrate. Polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) revealed that each sample was dominated by unique microbial populations, regardless of sampling location. The consortia were dominated by known PAHs degraders including Sphingomonas, Pseudomonas, and Sphingobium; and previously unknown degraders such as Dokdonella and Luteimonas. A potentially novel and PAH-degrading Dokdonella was detected for the first time. PAH-ring hydroxylating dioxygenase (PAH-RHDα) gene was shown to be more effective than nidA in estimating pyrene-degrading bacteria in the enriched consortia. The consortia obtained in this study are potential candidates for remediation of PAHs contaminated soils.

  12. Microalgae consortia cultivation in dairy wastewater to improve the potential of nutrient removal and biodiesel feedstock production.

    Science.gov (United States)

    Qin, Lei; Wang, Zhongming; Sun, Yongming; Shu, Qing; Feng, Pingzhong; Zhu, Liandong; Xu, Jin; Yuan, Zhenhong

    2016-05-01

    The potential of microalgae consortia used in dairy wastewater treatment combined with microalgae biodiesel feedstock production was evaluated by comparing the nutrient removal of dairy wastewater, the growth of cells, and the lipid content and composition of biomass between monoalgae and microalgae consortia cultivation system. Our results showed that higher chemical oxygen demand (COD) removal (maximum, 57.01-62.86 %) and total phosphorus (TP) removal (maximum, 91.16-95.96 %) were achieved in almost microalgae consortia cultivation system than those in Chlorella sp. monoalgae cultivation system (maximum, 44.76 and 86.74 %, respectively). In addition, microalgae consortia cultivation except the mixture of Chlorella sp. and Scenedesmus spp. reached higher biomass concentration (5.11-5.41 g L(-1)), biomass productivity (730.4-773.2 mg L(-1) day(-1)), and lipid productivity (143.7-150.6 mg L(-1) day(-1)) than those of monoalgae cultivation (4.72 g L(-1), 674.3, and 142.2 mg L(-1) day(-1), respectively) on the seventh day. Furthermore, the fatty acid methyl ester (FAME) profiles indicated the lipids produced from microalgae consortia cultivation system were more suitable for biodiesel production. The microalgae consortia display superiority in dairy wastewater treatment and the getting feedstock for biodiesel production.

  13. Resource Sharing Among ISRO Libraries : a Case Study of Consortia Approach

    OpenAIRE

    M.S. Sridhar

    2002-01-01

    The paper presents a practical step by step approach and efforts made to achieve huge savings in acquisition expenditures and creative resources sharing among a group of libraries working under a single parent institution, namely, Indian Space Research Organisation (ISRO). Actual cases of substantial savings in subscription to costly journals, CD-ROM databases and conference volumes in the way of consortia price and/or combination (print and electronic) subscription prices are depicted with...

  14. Library purchasing consortia in the UK: activity, benefits and good practice.

    OpenAIRE

    Pye, Jo; Ball, David

    1999-01-01

    Following a brief introduction in Section 1, Section 2 sets out the operational context of library purchasing consortia. A range of key factors have shaped recent developments in the four LIS sectors under consideration (FE, HE, health and public libraries); some have exerted a common influence over all (e.g. information technology, European Commission purchasing directives, new central government, decline in bookfunds); some are sector-specific (e.g. purchasing arrangements, regional adminis...

  15. Metagenomes from two microbial consortia associated with Santa Barbara seep oil.

    Science.gov (United States)

    Hawley, Erik R; Malfatti, Stephanie A; Pagani, Ioanna; Huntemann, Marcel; Chen, Amy; Foster, Brian; Copeland, Alexander; del Rio, Tijana Glavina; Pati, Amrita; Jansson, Janet R; Gilbert, Jack A; Tringe, Susannah Green; Lorenson, Thomas D; Hess, Matthias

    2014-12-01

    The metagenomes from two microbial consortia associated with natural oils seeping into the Pacific Ocean offshore the coast of Santa Barbara (California, USA) were determined to complement already existing metagenomes generated from microbial communities associated with hydrocarbons that pollute the marine ecosystem. This genomics resource article is the first of two publications reporting a total of four new metagenomes from oils that seep into the Santa Barbara Channel.

  16. PREPARATIVE ISOLATION AND PURIFICATION OF CHEMICAL CONSTITUENTS OF BELAMCANDA BY MPLC, HSCCC AND PREP-HPLC

    Science.gov (United States)

    Wang, Xiaohong; Liang, Yong; Peng, Cuilin; Xie, Huichun; Pan, Man; Zhang, Tianyou; Ito, Yoichiro

    2010-01-01

    Combined with medium-pressure liquid chromatography (MPLC) and preparative high-pressure liquid chromatography (Prep-HPLC), high-speed countercurrent chromatography (HSCCC) was successfully applied for separation and purification of isoflavonoids from the extract of belamcanda. HSCCC separation was performed on a two-phase solvent system composed of methyl tert-butyl ether -ethyl acetate - n-butyl alcohol – acetonitrile −0.1% aqueous trifluoroacetic acid at a volume radio of 1:2:1:1:5. Semi-purified peak fractions from HSCCC separation were further purified by Prep-HPLC. Nine well-separated fractions were analyzed by HPLC-UV absorption spectrometry to determine their purities and characterized with ESI-MSn. Except for peaksland VII (unknown) seven compounds were identified as apocynin (peak II), mangiferin (peak III), 7-O-methylmangiferin (peak IV), hispidulin (peak V), 3′-hydroxyltectoridin (peak VI), iristectorin B (peak VII), isoiridin (peak IX). PMID:21552369

  17. Supplier challenges in health tech innovation

    DEFF Research Database (Denmark)

    Rolfstam, Max

    Suppliers, in particular small innovative firms, is an important contributor not only for innovation in health-tech, but also a component to consider in the light of the emerging policy interest for using public procurement as a means to stimulate innovation. Research on barriers preventing...... these firms from providing innovations to public health authorities is therefore easily justified. Although substantive knowledge already prevails on the topic, it appears to be a lack in the literature concerning small innovative firms. To help to overcome this gap the paper discusses preliminary case study...... findings collected in the context of the Baltic Sea Health Region HealthPort project. The overall aim with the project was to facilitate ‘business acceleration’ by providing support, training and bridging innovative SMEs and health care organisations ultimately to strengthen the Baltic Sea Region health...

  18. Identification and resolution of microdiversity through metagenomic sequencing of parallel consortia

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, William C.; Maezato, Yukari; Wu, Yu-Wei; Romine, Margaret F.; Lindemann, Stephen R.

    2016-01-01

    To gain a predictive understanding of the interspecies interactions within microbial communities that govern community function, the genomic complement of every member population must be determined. Although metagenomic sequencing has enabled the de novo reconstruction of some microbial genomes from environmental communities, microdiversity confounds current genome reconstruction techniques. To overcome this issue, we performed short-read metagenomic sequencing on parallel consortia, defined as consortia cultivated under the same conditions from the same natural community with overlapping species composition. The differences in species abundance between the two consortia allowed reconstruction of near-complete (est. >85% of gene complement) genome sequences for 17 of the 20 detected member species and revealed two Halomonas spp. and two Rhodobacteraceae sp. variants indistinguishable by amplicon analysis. Genomic comparison of these representative instances of inter- and intraspecies microdiversity suggest different mechanisms may result in expression of distinct roles in the community. In addition, isolation and complete genome sequence determination of six member species allowed an investigation into the sensitivity and specificity of genome reconstruction processes, demonstrating robustness across a wide range of sequence coverage (9x – 2700x).

  19. Functional Stability Of A Mixed Microbial Consortia Producing PHA From Waste Carbon Sources

    Energy Technology Data Exchange (ETDEWEB)

    David N. Thompson; Erik R. Coats; William A. Smith; Frank J. Loge; Michael P. Wolcott

    2006-04-01

    Polyhydroxyalkanoates (PHAs), naturally-occurring biological polyesters that are microbially synthesized from a myriad of carbon sources, can be utilized as biodegradable substitutes for petroleum-derived thermoplastics. However, current PHA commercialization schemes are limited by high feedstock costs, the requirement for aseptic reactors, and high separation and purification costs. Bacteria indigenous to municipal waste streams can accumulate large quantities of PHA under environmentally controlled conditions; hence, a potentially more environmentally-effective method of production would utilize these consortia to produce PHAs from inexpensive waste carbon sources. In this study, PHA production was accomplished in sequencing batch bioreactors utilizing mixed microbial consortia from municipal activated sludge as inoculum, in cultures grown on real wastewaters. PHA production averaged 85%, 53%, and 10% of the cell dry weight from methanol-enriched pulp-and-paper mill foul condensate, fermented municipal primary solids, and biodiesel wastewater, respectively. The PHA-producing microbial consortia were examined to explore the microbial community changes that occurred during reactor operations, employing denaturing gradient gel electrophoresis (DGGE) of 16S-rDNA from PCR-amplified DNA extracts. Distinctly different communities were observed both between and within wastewaters following enrichment. More importantly, stable functions were maintained despite the differing and contrasting microbial populations.

  20. Collaborative cancer epidemiology in the 21st century: the model of cancer consortia.

    Science.gov (United States)

    Burgio, Michael R; Ioannidis, John P A; Kaminski, Brett M; Derycke, Eric; Rogers, Scott; Khoury, Muin J; Seminara, Daniela

    2013-12-01

    During the last two decades, epidemiology has undergone a rapid evolution toward collaborative research. The proliferation of multi-institutional, interdisciplinary consortia has acquired particular prominence in cancer research. Herein, we describe the characteristics of a network of 49 established cancer epidemiology consortia (CEC) currently supported by the Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI). This collection represents the largest disease-based research network for collaborative cancer research established in population sciences. We describe the funding trends, geographic distribution, and areas of research focus. The CEC have been partially supported by 201 grants and yielded 3,876 publications between 1995 and 2011. We describe this output in terms of interdisciplinary collaboration and translational evolution. We discuss challenges and future opportunities in the establishment and conduct of large-scale team science within the framework of CEC, review future prospects for this approach to large-scale, interdisciplinary cancer research, and describe a model for the evolution of an integrated Network of Cancer Consortia optimally suited to address and support 21st-century epidemiology.

  1. THE BSC AND THE HEALTH MANAGEMENT CONSORTIA: A CASE STUDY OF ITS APPLICABILITY

    Directory of Open Access Journals (Sweden)

    Juliana Caroline Coutinho Coelho Guimarães

    2012-12-01

    Full Text Available The professional management development consistent with the demands of society is an undeniable reality in Public Health. The enactment of 11.107/2005 Law inserts an agenda for change in the reality of Health Consortia. Against this backdrop of change, uncertainty and social costs, we need to rethink management practices. The management supporting tools have been evolving rapidly since 1980, highlighting the Balanced Scorecard (BSC. The adoption of the BSC as a management supporting tool to consortia comes to meet the existing demand to improve professionalization in public administration. This article aims to analyze the applicability of a support management tool to a Health Consortia, based on BSC through a proposed pilot project in a consortium selected to do so. Thus, for the realization of this work, designed a Case Study in CISMEV - Consortium Health of Middle Velhas River, and developed a proposal for the construction of the BSC with nine distinct steps. Thus, it was possible to identify the key steps to be met for the adoption of new procedures and routines, as well as the challenges encountered in the development process of the BSC by public institutions. We also identified the possible gains from deploying this tool culminating in fulfilling the mission and building the organizational vision. It was felt that identifying motivators for choosing this tool, as well as their strengths and limitations are essential to the construction of this process with greater criticality.

  2. Developing multicenter consortia in liver disease in Latin America: Challenges and opportunities.

    Science.gov (United States)

    Mendizabal, Manuel; Silva, Marcelo O

    2017-09-01

    The development of consortia has been useful for exploring challenging scenarios and uncharted territories in liver disease treatments. Several consortia already developed in the United States and Europe have become key factors in patient care decision-making processes and medical education, and they have also impacted policy makers' decisions. In Latin America, the situation is different. As a result of a combination of different factors, our region has not been able to develop networking advantages in research and education in liver diseases. Thus far, most of the initial experiences focused on the development of collaborative groups established to investigate a particular topic, which were dissolved once the questions were answered. It is the aim of this review to describe those difficulties we confront in developing multicenter liver consortia in Latin America, to identify those challenges we face, and also to describe the opportunities we have for improvement. Liver Transplantation 23 1210-1215 2017 AASLD. © 2017 by the American Association for the Study of Liver Diseases.

  3. Metagenomic analysis of uncultured Cytophaga and beta-1,4 glycanases in marine consortia

    Energy Technology Data Exchange (ETDEWEB)

    David Kirchman

    2005-12-15

    Culture-independent studies have shown that microbial consortia in natural environments are incredibly diverse and are dominated by bacteria and archaea substantially different from microbes maintained in pure laboratory cultures. Recent studies indicate, however, that previous culture-independent studies using PCR-based methods have largely overlook an important group of uncultured bacteria, the Cytophagales. These bacteria appear to be abundant in the oceans and probably other oxic environments. Although well known to be active in degradation of structural glycans such as cellulose and chitin, no cellulase or chitinase gene has been sequenced from a Cytophaga, except those recently found by whole genome sequencing of Cytophaga hutchinsonii by the DOE Joint Genome Institute (JGI). We hypothesize that the key to understanding consortia and their function in organic matter mineralization in oxic environments is to focus on uncultured Cytophagales, genes encoding endoglycanases, and other functional genes. The ''metagenomic'' approach used by this project consisted of constructing large insert libraries with DNA directly (no PCR) from uncultured microbial consortia found in the Arctic Ocean and Delaware Estuary. Our results provide insights into new types of bacterial metabolisms which have not considered adequately before, but which may change our views of the global carbon cycle.

  4. Trophic interactions induce spatial self-organization of microbial consortia on rough surfaces.

    Science.gov (United States)

    Wang, Gang; Or, Dani

    2014-10-24

    The spatial context of microbial interactions common in natural systems is largely absent in traditional pure culture-based microbiology. The understanding of how interdependent microbial communities assemble and coexist in limited spatial domains remains sketchy. A mechanistic model of cell-level interactions among multispecies microbial populations grown on hydrated rough surfaces facilitated systematic evaluation of how trophic dependencies shape spatial self-organization of microbial consortia in complex diffusion fields. The emerging patterns were persistent irrespective of initial conditions and resilient to spatial and temporal perturbations. Surprisingly, the hydration conditions conducive for self-assembly are extremely narrow and last only while microbial cells remain motile within thin aqueous films. The resulting self-organized microbial consortia patterns could represent optimal ecological templates for the architecture that underlie sessile microbial colonies on natural surfaces. Understanding microbial spatial self-organization offers new insights into mechanisms that sustain small-scale soil microbial diversity; and may guide the engineering of functional artificial microbial consortia.

  5. Cd and proton adsorption onto bacterial consortia grown from industrial wastes and contaminated geologic settings.

    Science.gov (United States)

    Borrok, David M; Fein, Jeremy B; Kulpa, Charles F

    2004-11-01

    To model the effects of bacterial metal adsorption in contaminated environments, results from metal adsorption experiments involving individual pure stains of bacteria must be extrapolated to systems in which potentially dozens of bacterial species are present. This extrapolation may be made easier because bacterial consortia from natural environments appear to exhibit similar metal binding properties. However, bacteria that thrive in highly perturbed contaminated environments may exhibit significantly different adsorptive behavior. Here we measure proton and Cd adsorption onto a range of bacterial consortia grown from heavily contaminated industrial wastes, groundwater, and soils. We model the results using a discrete site surface complexation approach to determine binding constants and site densities for each consortium. The results demonstrate that bacterial consortia from different contaminated environments exhibit a range of total site densities (approximately a 3-fold difference) and Cd-binding constants (approximately a 10-fold difference). These ranges for Cd binding constants may be small enough to suggest that bacteria-metal adsorption in contaminated environments can be described using relatively few "averaged" bacteria-metal binding constants (in conjunction with the necessary binding constants for competing surfaces and ligands). However, if additional precision is necessary, modeling parameters must be developed separately for each contaminated environment of interest.

  6. Microscale sulfur cycling in the phototrophic pink berry consortia of the Sippewissett Salt Marsh.

    Science.gov (United States)

    Wilbanks, Elizabeth G; Jaekel, Ulrike; Salman, Verena; Humphrey, Parris T; Eisen, Jonathan A; Facciotti, Marc T; Buckley, Daniel H; Zinder, Stephen H; Druschel, Gregory K; Fike, David A; Orphan, Victoria J

    2014-11-01

    Microbial metabolism is the engine that drives global biogeochemical cycles, yet many key transformations are carried out by microbial consortia over short spatiotemporal scales that elude detection by traditional analytical approaches. We investigate syntrophic sulfur cycling in the 'pink berry' consortia of the Sippewissett Salt Marsh through an integrative study at the microbial scale. The pink berries are macroscopic, photosynthetic microbial aggregates composed primarily of two closely associated species: sulfide-oxidizing purple sulfur bacteria (PB-PSB1) and sulfate-reducing bacteria (PB-SRB1). Using metagenomic sequencing and (34) S-enriched sulfate stable isotope probing coupled with nanoSIMS, we demonstrate interspecies transfer of reduced sulfur metabolites from PB-SRB1 to PB-PSB1. The pink berries catalyse net sulfide oxidation and maintain internal sulfide concentrations of 0-500 μm. Sulfide within the berries, captured on silver wires and analysed using secondary ion mass spectrometer, increased in abundance towards the berry interior, while δ(34) S-sulfide decreased from 6‰ to -31‰ from the exterior to interior of the berry. These values correspond to sulfate-sulfide isotopic fractionations (15-53‰) consistent with either sulfate reduction or a mixture of reductive and oxidative metabolisms. Together this combined metagenomic and high-resolution isotopic analysis demonstrates active sulfur cycling at the microscale within well-structured macroscopic consortia consisting of sulfide-oxidizing anoxygenic phototrophs and sulfate-reducing bacteria.

  7. Effect of nitrogen supplementation on aerobic degradation of linear alkylbenzene sulfonate by consortia of bacteria

    Directory of Open Access Journals (Sweden)

    Kehinde I. Temitope Eniola

    2012-05-01

    Full Text Available Untreated detergent bearing wastes discharged into the environment are sources of linear alkylbenzene sulfonate (LAS. Detergent wastes usually do not contain nitrogen or contain very low amounts. Biostimulation by introducing limiting nutrient element can be useful in biotreatment of such waste. The effect of inorganic and organic nitrogen supplements on aerobic degradation of LAS by LAS-utilizing bacteria was examined. Phosphate-buffered LAS mineral media were prepared and supplemented with different nitrogen sources: NPK fertilizer (inorganic and urea fertilizer (organic. Individual and various consortia of pure cultures of Alcaligenes odorans, Citrobacter diversus, Micrococcus luteus and Pseudomonas putida, previously isolated from a detergent effluent polluted stream, were used. Biodegradation of LAS was monitored in terms of half-life (t½ of the surfactant. The rates of biodegradation by the consortia can be ranked as: 4-membered (t½=8-12 days >3-membered (t½=8-13 days >2-membered consortia (t½=10-15 days >individuals (t½=9-16 days. The inorganic nitrogen source enhanced utilization of the surfactant, while organic nitrogen supplementation generally slowed degradation of the surfactant. In undertaking biotreatment of detergent bearing effluent, inorganic nitrogen should be used as biostimulant.

  8. Applicability of cryoconite consortia of microorganisms and glacier-dwelling animals in astrobiological studies

    Science.gov (United States)

    Zawierucha, Krzysztof; Ostrowska, Marta; Kolicka, Małgorzata

    2017-06-01

    For several years it has been of interest to astrobiologists to focus on Earth's glaciers as a habitat that can be similar to glaciers on other moons and planets. Microorganisms on glaciers form consortia - cryoconite granules (cryoconites). They are granular/spherical mineral particles connected with archaea, cyanobacteria, heterotrophic bacteria, algae, fungi, and micro animals (mainly Tardigrada and Rotifera). Cryophilic organisms inhabiting glaciers have been studied in different aspects: from taxonomy, ecology and biogeography, to searching of biotechnological potentials and physiological strategies to survive in extreme glacial habitats. However, they have never been used in astrobiological experiments. The main aim of this paper is brief review of literature and supporting assumptions that cryoconite granules and microinvertebrates on glaciers, are promising models in astrobiology for looking for analogies and survival strategies in terms of icy planets and moons. So far, astrobiological research have been conducted on single strains of prokaryotes or microinvertebrates but never on a consortium of them. Due to the hypothetical similarity of glaciers on the Earth to those on other planets these cryoconites consortia of microorganisms and glacier microinvertebrates may be applied in astrobiological experiments instead of the limno-terrestrial ones used currently. Those consortia and animals have qualities to use them in such studies and they may be the key to understanding how organisms are able to survive, reproduce and remain active at low temperatures.

  9. Swords, Shields, and the Fight for Our Children: Lessons from Urban Prep

    Science.gov (United States)

    King, Tim

    2011-01-01

    The grim statistics are well known, but bear repeating: in Chicago, close to 60% of Black boys do not graduate from high school, and only one in forty receive a bachelor's degree by age 25. In the fall of 2006, Urban Prep Charter Academy for Young Men-Englewood Campus, the nation's first all-male charter public high school, was opened. In 2010 and…

  10. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    OpenAIRE

    Arcelino Farias-Neto; Edna Maria da Cunha Ferreira Gomes; Alfonso Sánchez-Ayala; Alejandro Sánchez-Ayala; Larissa Soares Reis Vilanova

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents e...

  11. Secrecy, empowerment and protection: positioning PrEP in KwaZulu-Natal, South Africa.

    Science.gov (United States)

    Govender, Eliza; Mansoor, Leila; MacQueen, Kate; Abdool Karim, Quarraisha

    2017-11-01

    The release of World Health Organisation guidelines recommending the prophylactic use of daily Truvada(®) for all populations at high risk of acquiring HIV opens the way for implementation of oral pre-exposure prophylaxis (PrEP). The impact of new prevention technologies is, however, dependent on demand creation strategies such as user awareness, acceptability and access, which in turn are influenced by sociocultural and gender norms. This study was conducted in three locations in KwaZulu-Natal, urban, rural and peri-urban, with six participatory workshops. Knowledge, desirable features of a product and demand positioning for PrEP were assessed using a participatory action media research process which included art-based activities and group discussion using a semi-structured interview schedule. The data were analysed using thematic analysis. The key themes that emerged in relation to product adoption were: ability to maintain secrecy of product use; the need for agency with personal choices around HIV prevention; and an increased desire for HIV protection. Findings reaffirm the influence of user engagement in understanding the sociocultural dynamics that influence demand creation for PrEP adoption.

  12. No association between the PREP gene and lithium responsive bipolar disorder

    Directory of Open Access Journals (Sweden)

    Grof Paul

    2007-02-01

    Full Text Available Abstract Background Bipolar disorder (BD is a major psychiatric condition that commonly requires prophylactic and episodic treatment. Lithium (Li has been used for over 40 years now as an effective prophylactic agent. Response to Li treatment seems to be, at least in part, genetically determined. Although we ignore how Li specifically prevents mood episodes, it has previously been suggested that Li exerts an effect on the phosphoinositide pathway, and more recently, it has been proposed that Li may modulate prolyl endopeptidase (PREP. Methods In this study we carried out an association study looking at the PREP gene, located on ch 6q22. Five intronic single nucleotide polymorphisms (SNP, three coding SNPs and one SNP in the 5' UTR were investigated for their frequency in a BD sample of 180 excellent Li responders, 69 Li nonresponders and 126 controls. Genotyping was carried out using the SNaPshot reaction from Applied Biosystems, which is a modified fluorescent single base pair extension procedure. Results Following correction for multiple testing, no significant genotypic, allelic or estimated haplotypic differences were found between responders and nonresponders or between BD patients and controls. Conclusion PREP is an interesting candidate gene to investigate in genetic studies of BD, but our findings do not support the hypothesis that genetic variation in this gene plays a major role in the etiology of BD or Li response.

  13. FinTech – What's in a Name?

    OpenAIRE

    Zavolokina, Liudmila; Dolata, Mateusz; Schwabe, Gerhard

    2016-01-01

    FinTech, the word which originates from marriage of “finance” and “technology”, designates currently a novel, innovative and emerging field which attracts attention from the publicity. At the moment there is no universal understanding and definition of FinTech in the research, however, the topic is widely addressed by the English- and German-speaking press. In this study we aim to make insights into how the press and other popular media understand and frame FinTech, discussing definitions tha...

  14. Fee-based services in sci-tech libraries

    CERN Document Server

    Mount, Ellis

    2013-01-01

    This timely and important book explores how fee-based services have developed in various types of sci-tech libraries. The authoritative contributors focus on the current changing financial aspects of the sci-tech library operation and clarify for the reader how these changes have brought about conditions in which traditional methods of funding are no longer adequate. What new options are open and how they are best being applied in today's sci-tech libraries is fully and clearly explained and illustrated. Topics explored include cost allocation and cost recovery, fees for computer searching, an

  15. An analisys of consumers’ expenditures on high-tech products

    Directory of Open Access Journals (Sweden)

    Dovleac, L.

    2011-01-01

    Full Text Available High – tech products are gradually adopted by consumers, who become to consider them indispensable. Their acquisition requires each time a pretty significant financial investment and a serious decision with a high perceived risk. In this paper we intend to analyse some financial issues related to high-tech products purchased by consumers from Brasov city in 2009, such as: the amount of money spent on high tech products, the financial sources used, the connections between expenditures and consumer’s characteristics.

  16. China's High-tech Exports: Myth and Reality

    OpenAIRE

    Xing, Yuqing

    2011-01-01

    China’s leading position in high-tech exports is a myth created by outdated trade statistics, which are inconsistent with the trade based on global supply chains. Assembled high-tech products, made with imported key parts and components, accounted for 82% of China’s high-tech exports. Current trade statistics mistakenly credit entire values of these assembled products to China, thus greatly inflate the export value. For instance, in 2009 China’s export in the iPhone amounted US$4.6 billion, o...

  17. FinTech – What's in a Name?

    OpenAIRE

    Zavolokina, Liudmila; Dolata, Mateusz; Schwabe, Gerhard

    2016-01-01

    FinTech, the word which originates from marriage of “finance” and “technology”, designates currently a novel, innovative and emerging field which attracts attention from the publicity. At the moment there is no universal understanding and definition of FinTech in the research, however, the topic is widely addressed by the English- and German-speaking press. In this study we aim to make insights into how the press and other popular media understand and frame FinTech, discussing definitions tha...

  18. Metataxonomic profiling and prediction of functional behaviour of wheat straw degrading microbial consortia.

    Science.gov (United States)

    Jiménez, Diego Javier; Dini-Andreote, Francisco; van Elsas, Jan Dirk

    2014-01-01

    Mixed microbial cultures, in which bacteria and fungi interact, have been proposed as an efficient way to deconstruct plant waste. The characterization of specific microbial consortia could be the starting point for novel biotechnological applications related to the efficient conversion of lignocellulose to cello-oligosaccharides, plastics and/or biofuels. Here, the diversity, composition and predicted functional profiles of novel bacterial-fungal consortia are reported, on the basis of replicated aerobic wheat straw enrichment cultures. In order to set up biodegradative microcosms, microbial communities were retrieved from a forest soil and introduced into a mineral salt medium containing 1% of (un)treated wheat straw. Following each incubation step, sequential transfers were carried out using 1 to 1,000 dilutions. The microbial source next to three sequential batch cultures (transfers 1, 3 and 10) were analyzed by bacterial 16S rRNA gene and fungal ITS1 pyrosequencing. Faith's phylogenetic diversity values became progressively smaller from the inoculum to the sequential batch cultures. Moreover, increases in the relative abundances of Enterobacteriales, Pseudomonadales, Flavobacteriales and Sphingobacteriales were noted along the enrichment process. Operational taxonomic units affiliated with Acinetobacter johnsonii, Pseudomonas putida and Sphingobacterium faecium were abundant and the underlying strains were successfully isolated. Interestingly, Klebsiella variicola (OTU1062) was found to dominate in both consortia, whereas K. variicola-affiliated strains retrieved from untreated wheat straw consortia showed endoglucanase/xylanase activities. Among the fungal players with high biotechnological relevance, we recovered members of the genera Penicillium, Acremonium, Coniochaeta and Trichosporon. Remarkably, the presence of peroxidases, alpha-L-fucosidases, beta-xylosidases, beta-mannases and beta-glucosidases, involved in lignocellulose degradation, was indicated

  19. Population dynamics of two antilisterial cheese surface consortia revealed by temporal temperature gradient gel electrophoresis

    Directory of Open Access Journals (Sweden)

    Hasler Madlen

    2010-03-01

    Full Text Available Abstract Background Surface contamination of smear cheese by Listeria spp. is of major concern for the industry. Complex smear ecosystems have been shown to harbor antilisterial potential but the microorganisms and mechanisms involved in the inhibition mostly remain unclear, and are likely related to complex interactions than to production of single antimicrobial compounds. Bacterial biodiversity and population dynamics of complex smear ecosystems exhibiting antilisterial properties in situ were investigated by Temporal temperature gradient gel electrophoresis (TTGE, a culture independent technique, for two microbial consortia isolated from commercial Raclette type cheeses inoculated with defined commercial ripening cultures (F or produced with an old-young smearing process (M. Results TTGE revealed nine bacterial species common to both F and M consortia, but consortium F exhibited a higher diversity than consortium M, with thirteen and ten species, respectively. Population dynamics were studied after application of the consortia on fresh-produced Raclette cheeses. TTGE analyses revealed a similar sequential development of the nine species common to both consortia. Beside common cheese surface bacteria (Staphylococcus equorum, Corynebacterium spp., Brevibacterium linens, Microbacterium gubbeenense, Agrococcus casei, the two consortia contained marine lactic acid bacteria (Alkalibacterium kapii, Marinilactibacillus psychrotolerans that developed early in ripening (day 14 to 20, shortly after the growth of staphylococci (day 7. A decrease of Listeria counts was observed on cheese surface inoculated at day 7 with 0.1-1 × 102 CFU cm-2, when cheeses were smeared with consortium F or M. Listeria counts went below the detection limit of the method between day 14 and 28 and no subsequent regrowth was detected over 60 to 80 ripening days. In contrast, Listeria grew to high counts (105 CFU cm-2 on cheeses smeared with a defined surface culture

  20. Framing HIV Pre-Exposure Prophylaxis (PrEP) for the General Public: How Inclusive Messaging May Prevent Prejudice from Diminishing Public Support.

    Science.gov (United States)

    Calabrese, Sarah K; Underhill, Kristen; Earnshaw, Valerie A; Hansen, Nathan B; Kershaw, Trace S; Magnus, Manya; Krakower, Douglas S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

    2016-07-01

    Strategic framing of public messages about HIV pre-exposure prophylaxis (PrEP) may influence public support for policies and programs affecting access. This survey study examined how public attitudes toward PrEP differed based on the social group PrEP was described as benefiting ("beneficiary") and the moderating effect of prejudice. Members of the general public (n = 154) recruited online were randomly assigned to three beneficiary conditions: general population, gay men, or Black gay men. All participants received identical PrEP background information before completing measures of PrEP attitudes (specifying beneficiary), racism, and heterosexism. Despite anticipating greater PrEP adherence among gay men and Black gay men and perceiving PrEP as especially beneficial to the latter, participants expressed lower support for policies/programs making PrEP affordable for these groups vs. the general population. This disparity in support was stronger among participants reporting greater prejudice. Inclusive framing of PrEP in public discourse may prevent prejudice from undermining implementation efforts.

  1. The effect of the source of microorganisms on adaptation of hydrolytic consortia dedicated to anaerobic digestion of maize silage.

    Science.gov (United States)

    Poszytek, Krzysztof; Pyzik, Adam; Sobczak, Adam; Lipinski, Leszek; Sklodowska, Aleksandra; Drewniak, Lukasz

    2017-02-17

    The main aim of this study was to evaluate the effect of the source of microorganisms on the selection of hydrolytic consortia dedicated to anaerobic digestion of maize silage. The selection process was investigated based on the analysis of changes in the hydrolytic activity and the diversity of microbial communities derived from (i) a hydrolyzer of a commercial agricultural biogas plant, (ii) cattle slurry and (iii) raw sewage sludge, during a series of 10 passages. Following the selection process, the adapted consortia were thoroughly analyzed for their ability to utilize maize silage and augmentation of anaerobic digestion communities. The results of selection of the consortia showed that every subsequent passage of each consortium leads to their adaptation to degradation of maize silage, which was manifested by the increased hydrolytic activity of the adapted consortia. Biodiversity analysis (based on the 16S rDNA amplicon sequencing) confirmed the changes microbial community of each consortium, and showed that after the last (10th) passage all microbial communities were dominated by the representatives of Lactobacillaceae, Prevotellaceae, Veillonellaceae. The results of the functional analyses showed that the adapted consortia improved the efficiency of maize silage degradation, as indicated by the increase in the concentration of glucose and volatile fatty acids (VFAs), as well as the soluble chemical oxygen demand (sCOD). Moreover, bioaugmentation of anaerobic digestion communities by the adapted hydrolytic consortia increased biogas yield by 10-29%, depending on the origin of the community. The obtained results also indicate that substrate input (not community origin) was the driving force responsible for the changes in the community structure of hydrolytic consortia dedicated to anaerobic digestion.

  2. Virginia Tech, Sweet Briar College formalize student exchange program

    OpenAIRE

    Owczarski, Mark

    2006-01-01

    Virginia Tech and Sweet Briar College have formalized a student exchange program that will broaden the education opportunities of students, provide a diverse campus environment, and facilitate cooperation and collaboration among student and faculty at each institution.

  3. Lavender Commencement Ceremony to honor LGBT graduates at Virginia Tech

    OpenAIRE

    Shannon, Kelly Baker

    2010-01-01

    The Lesbian, Gay, Bisexual, and Transgender (LGBT) Caucus at Virginia Tech is sponsoring the Second Annual Lavender Commencement Ceremony, which will be held on May 13 at 11 a.m. in the Old Dominion Ballroom of Squires Student Center.

  4. Events Scheduled for Virginia Tech's Black History Month

    OpenAIRE

    Felker, Susan B.

    2004-01-01

    A variety of lectures, discussions, performances and displays will be held during Virginia Tech's observance of Black History Month. Events begin Jan. 19 and run through Feb. 28 and are free an open to the public (except where noted).

  5. The Trail Inventory of Bayou Teche NWR [Cycle 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Bayou Teche National Wildlife Refuge. Trails in this inventory are...

  6. Virginia Tech Horse Judging Team leaves its mark in Texas

    OpenAIRE

    Greiner, Lori A.

    2010-01-01

    The Virginia Tech Horse Judging Team completed a successful spring competition season with a win at the American Paint Horse Association's Spring Intercollegiate Horse Judging Sweepstakes in Fort Worth, Texas.

  7. Virginia Tech remains among best values in public higher education

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Virginia Tech is again ranked among the top public colleges and universities in the nation that offer a high quality educational experience at an affordable price, according to "Kiplinger's Personal Finance" magazine.

  8. Virginia Tech recognized for world-class food science program

    OpenAIRE

    Sutphin, Michael D.

    2010-01-01

    The Institute of Food Technologists (IFT) has reaccredited the undergraduate curriculum of Virginia Tech's Department of Food Science and Technology, reaffirming the department's place as a leader in contributing to food quality, safety, marketability, and availability.

  9. Virginia Tech's Cook Counseling Center receives international counseling accreditation

    OpenAIRE

    DeLauder, Rachel

    2010-01-01

    The Virginia Tech Thomas E. Cook Counseling Center has been accredited by the International Association of Counseling Services, Inc., an organization of United States, Canadian, and Australian counseling agencies based in Alexandria, Va.

  10. Bayou Teche National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Bayou Teche NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  11. Bayou Teche National Wildlife Refuges Habitat Management Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Bayou Teche NWR Habitat Management Plan provides a long-term vision and specific guidance on managing habitats for the resources of concern at Bayou Sauvage NWR,...

  12. Pricing Policy and Strategies for Consumer High-Tech Products

    Directory of Open Access Journals (Sweden)

    Dovleac, L.

    2014-06-01

    Full Text Available This paper highlights the complex process of price setting for consumer high-tech products. These prices are highly influenced by some external factors from the economic and social environment. The main objective of this paper is to establish the most effective pricing policies and strategies used by high-tech companies of various sizes. Decisions about price fixing for consumer high-technology products are largely influenced by consumer behaviour, too.

  13. Overseas Tech Firms Ramp Up Hiring In Silicon Valley

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Fpr years, U.S.high-tech executives have fretted about the loss of technology jobs to countries such as China and India.But there is a countervailing force: Foreign companies are leaning heavily on engineers they hire in Silicon Valley. Companies from Europe and Asia increasingly are using high-tech teams in the Bay Area to conduct long-range research and help design cutting-edge products for global markets.

  14. Virginia Tech creates Caribbean center for education and research

    OpenAIRE

    Felker, Susan B.

    2006-01-01

    Virginia Tech has established a research, education, and outreach center in the Caribbean that will serve as part of a broad strategy to create international centers of scholarship around the world. The Caribbean Center for Education and Research (CCER) in Punta Cana, on the eastern tip of the Dominican Republic, will allow Virginia Tech faculty to conduct research as well as instruct students on biodiversity, environmental and social sustainability, global issues in natural resources, and ho...

  15. Slow Tech: The Bridge between Computer Ethics and Business Ethics

    OpenAIRE

    Patrignani, Norberto; Whitehouse, Diane

    2014-01-01

    Part 1: Society, Social Responsibility, Ethics and ICT; International audience; This paper addresses the difficult task of implementing the concept of Slow Tech, that is, information and communication technology (ICT) that is good, clean and fair, in a business environment. It investigates the democratic, environmental, and social challenges currently facing ICT vendors. More specifically, it examines the opportunities available for these companies to use Slow Tech as a bridging mechanism bet...

  16. Promoting High-tech Industrialization through Mechanism Innovation

    Institute of Scientific and Technical Information of China (English)

    Guo Haiyan; Zhao Baohua

    2002-01-01

    @@ With the further implementation of the knowledge innovation program (KIP), piloted by the Chinese Academy of Sciences (CAS), encouraging progress has been made in contributing to the development of the country's high-tech industry, and forging S&T cooperation with local governments and industrial sectors. This was revealed at the Second CAS Conference on High-tech Industrialization April 25 - 29 in Shenzhen, Guangdong Province.

  17. Allina Health System's approach to high tech and high touch.

    Science.gov (United States)

    Tam, T A

    1997-01-01

    All health care providers, regardless of their integration status, must meet customer expectations to maintain market share and viability. The balance between high tech and high touch customer interactions is not a fad or trend. For integrated health systems with the full continuum of medical care, additional challenges are presented by the organization's competing health care delivery and financing components. Allina Health System describes its integrated health system approach to satisfying customer high tech and high touch needs.

  18. Acceptability of HIV Pre-Exposure Prophylaxis (PrEP) and Implementation Challenges Among Men Who Have Sex with Men in India: A Qualitative Investigation.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Mengle, Shruta; Varghese, Jarvis; Nelson, Ruban; Bharat, Shalini

    2015-10-01

    This qualitative study explored the acceptability of HIV pre-exposure prophylaxis (PrEP) among MSM in India, and identified facilitators and barriers to future PrEP uptake. In 2014, we conducted 10 focus groups (n=61) among a purposive sample of diverse MSM recruited through community-based organizations in Chennai and Mumbai, and 10 key informant interviews with community leaders and health care providers. Participants' mean age was 26.1 years (SD 4.8); 62% completed secondary education, and 42% engaged in sex work. No focus group participants had heard of PrEP, but once explained, most reported they would likely use it. PrEP was alternately perceived as a 'back-up plan', a condom substitute, or a burden with concurrent condom use. Facilitators were potential for covert use, sex without condoms, and anxiety-less sex. Potential barriers emerged around stigma associated with PrEP use, fear of disclosures to one's family, wife, or male steady partner, and being labeled as HIV-positive or promiscuous by peers. Preferences emerged for intermittent rather than daily PrEP use, injectable PrEP, and free or subsidized access through community organizations or government hospitals. Key informants expressed additional concerns about risk compensation, non-adherence, and impact on ART availability for treatment. Demonstration projects are needed in India to support PrEP implementation tailored for at-risk MSM. Educational interventions for MSM should address concerns about PrEP effectiveness, side effects, and mitigate risk compensation. Community engagement may facilitate broad acceptability and challenge stigma around PrEP use. Importantly, provision of free or subsidized PrEP is necessary to making implementation feasible among low socioeconomic status MSM in India.

  19. FinTech Market Development Perspectives

    Directory of Open Access Journals (Sweden)

    Kalmykova Ekaterina

    2016-01-01

    Full Text Available Fast development of technologies has led to emergence of the new market – FinTech – which is very attractive for investors today. By now this market has a great number of different concepts: P2P-crediting, E-wallets, Bitcoins, mPOS-acquiring, T-commerce, mobile banks, etc. Many of these tools have already heavily entered our ordinary life. People can obtain any credits through special services on the Internet from other users without participation of banks, pay by credit card using mobile devices, and get information about expenses and incomes according to the card anywhere in the world. Users do not need to go to banks anymore and to spend their time for credit arrangements, currency exchange, to look for ATMs to remove cash. Purchases on the Internet can be paid not only in rubles, but also in new digital currency. These tools make life easier, however, they pose a serious threat for banks. Now, bank institutions should create more convenient and utility services for the clients to keep clients. Therefore, bank and credit systems start to change actively.

  20. Georgia Tech Catalog of Gravitational Waveforms

    CERN Document Server

    Jani, Karan; Clark, James A; London, Lionel; Laguna, Pablo; Shoemaker, Deirdre

    2016-01-01

    This paper introduces a catalog of gravitational waveforms from the bank of simulations by the numerical relativity effort at Georgia Tech. Currently, the catalog consists of 452 distinct waveforms from more than 600 binary black hole simulations: 128 of the waveforms are from binaries with black hole spins aligned with the orbital angular momentum, and 324 are from precessing binary black hole systems. The waveforms from binaries with non-spinning black holes have mass-ratios $q = m_1/m_2 \\le 15$, and those with precessing, spinning black holes have $q \\le 8$. The waveforms expand a moderate number of orbits in the late inspiral, the burst during coalescence, and the ring-down of the final black hole. Examples of waveforms in the catalog matched against the widely used approximate models are presented. In addition, predictions of the mass and spin of the final black hole by phenomenological fits are tested against the results from the simulation bank. The role of the catalog in interpreting the GW150914 even...

  1. Iterest grows for Dutch mid-tech and low-tech greenhouse technology : A greenhouse to suit all tropical conditions (interview with Anne Elings)

    NARCIS (Netherlands)

    Kierkels, T.; Elings, A.

    2014-01-01

    The Netherlands sets the standard for high-tech greenhouses worldwide. But increasingly suppliers are looking too at possibilities within the mid-tech and even the low-tech market segments. The Dutch government is supporting demonstration projects, for example in Mexico, East Africa and Malaysia. Te

  2. Establishment of rumen-mimic bacterial consortia: A functional union for bio-hydrogen production from cellulosic bioresource

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jui-Jen [Genomics Research Center, Academia Sinica, Nankang, Taipei 115 (China); Lin, Jia-Jen; Ho, Cheng-Yu.; Chin, Wei-Chih; Huang, Chieh-Chen [Department of Life Sciences, National Chung Hsing University,Taichung (China)

    2010-12-15

    The study aimed to establish stable rumen-mimic bacterial consortia as a functional union for simultaneous saccharification and fermentation from cellulosic bioresource. The consortia was constructed by repeated-batch culture with ruminal microflora and napiergrass at 38 C. The major bacterial composition of batch culture was monitored by 16S rRNA gene-targeted denaturing gradient gel electrophoresis (DGGE). The result showed that a stable consortia constituted by ruminal microflora was formed, and the consortia includes bacterial strains such as Clostridium xylanolyticum, Clostridium papyrosolvens, Clostridium beijerinckii, Ruminococcus sp., Ethanoligenens harbinense, and Desulfovibrio desulfuricans. The Clostridium genus was showed as the dominant population in the system and contributed to the biohydrogen production. During each eight days incubation period, the functional consortia could degrade an average of 27% hemicellulose and 2% cellulose from napiergrass biomass. While the increasing of the reducing sugars and their converting to biohydrogen gas productivity were also observed. The time course profile for cellulytic enzymes showed that the hydrolysis of complex lignocellulosic material may occur through the ordered actions of xylenase and cellulase activities. (author)

  3. Genomic Reconstruction of Carbohydrate Utilization Capacities in Microbial-Mat Derived Consortia

    Directory of Open Access Journals (Sweden)

    Semen A. Leyn

    2017-07-01

    Full Text Available Two nearly identical unicyanobacterial consortia (UCC were previously isolated from benthic microbial mats that occur in a heliothermal saline lake in northern Washington State. Carbohydrates are a primary source of carbon and energy for most heterotrophic bacteria. Since CO2 is the only carbon source provided, the cyanobacterium must provide a source of carbon to the heterotrophs. Available genomic sequences for all members of the UCC provide opportunity to investigate the metabolic routes of carbon transfer between autotroph and heterotrophs. Here, we applied a subsystem-based comparative genomics approach to reconstruct carbohydrate utilization pathways and identify glycohydrolytic enzymes, carbohydrate transporters and pathway-specific transcriptional regulators in 17 heterotrophic members of the UCC. The reconstructed metabolic pathways include 800 genes, near a one-fourth of which encode enzymes, transporters and regulators with newly assigned metabolic functions resulting in discovery of novel functional variants of carbohydrate utilization pathways. The in silico analysis revealed the utilization capabilities for 40 carbohydrates and their derivatives. Two Halomonas species demonstrated the largest number of sugar catabolic pathways. Trehalose, sucrose, maltose, glucose, and beta-glucosides are the most commonly utilized saccharides in this community. Reconstructed regulons for global regulators HexR and CceR include central carbohydrate metabolism genes in the members of Gammaproteobacteria and Alphaproteobacteria, respectively. Genomics analyses were supplemented by experimental characterization of metabolic phenotypes in four isolates derived from the consortia. Measurements of isolate growth on the defined medium supplied with individual carbohydrates confirmed most of the predicted catabolic phenotypes. Not all consortia members use carbohydrates and only a few use complex polysaccharides suggesting a hierarchical carbon flow from

  4. Biodegradation of different petroleum hydrocarbons by free and immobilized microbial consortia.

    Science.gov (United States)

    Shen, Tiantian; Pi, Yongrui; Bao, Mutai; Xu, Nana; Li, Yiming; Lu, Jinren

    2015-12-01

    The efficiencies of free and immobilized microbial consortia in the degradation of different types of petroleum hydrocarbons were investigated. In this study, the biodegradation rates of naphthalene, phenanthrene, pyrene and crude oil reached about 80%, 30%, 56% and 48% under the optimum environmental conditions of free microbial consortia after 7 d. We evaluated five unique co-metabolic substances with petroleum hydrocarbons, α-lactose was the best co-metabolic substance among glucose, α-lactose, soluble starch, yeast powder and urea. The orthogonal biodegradation analysis results showed that semi-coke was the best immobilized carrier followed by walnut shell and activated carbon. Meanwhile, the significance of various factors that contribute to the biodegradation of semi-coke immobilized microbial consortia followed the order of: α-lactose > semi-coke > sodium alginate > CaCl2. Moreover, the degradation rate of the immobilized microbial consortium (47%) was higher than that of a free microbial consortium (26%) under environmental conditions such as the crude oil concentration of 3 g L(-1), NaCl concentration of 20 g L(-1), pH at 7.2-7.4 and temperature of 25 °C after 5 d. SEM and FTIR analyses revealed that the structure of semi-coke became more porous and easily adhered to the microbial consortium; the functional groups (e.g., hydroxy and phosphate) were identified in the microbial consortium and were changed by immobilization. This study demonstrated that the ability of microbial adaptation to the environment can be improved by immobilization which expands the application fields of microbial remediation.

  5. Genomic Reconstruction of Carbohydrate Utilization Capacities in Microbial-Mat Derived Consortia

    Science.gov (United States)

    Leyn, Semen A.; Maezato, Yukari; Romine, Margaret F.; Rodionov, Dmitry A.

    2017-01-01

    Two nearly identical unicyanobacterial consortia (UCC) were previously isolated from benthic microbial mats that occur in a heliothermal saline lake in northern Washington State. Carbohydrates are a primary source of carbon and energy for most heterotrophic bacteria. Since CO2 is the only carbon source provided, the cyanobacterium must provide a source of carbon to the heterotrophs. Available genomic sequences for all members of the UCC provide opportunity to investigate the metabolic routes of carbon transfer between autotroph and heterotrophs. Here, we applied a subsystem-based comparative genomics approach to reconstruct carbohydrate utilization pathways and identify glycohydrolytic enzymes, carbohydrate transporters and pathway-specific transcriptional regulators in 17 heterotrophic members of the UCC. The reconstructed metabolic pathways include 800 genes, near a one-fourth of which encode enzymes, transporters and regulators with newly assigned metabolic functions resulting in discovery of novel functional variants of carbohydrate utilization pathways. The in silico analysis revealed the utilization capabilities for 40 carbohydrates and their derivatives. Two Halomonas species demonstrated the largest number of sugar catabolic pathways. Trehalose, sucrose, maltose, glucose, and beta-glucosides are the most commonly utilized saccharides in this community. Reconstructed regulons for global regulators HexR and CceR include central carbohydrate metabolism genes in the members of Gammaproteobacteria and Alphaproteobacteria, respectively. Genomics analyses were supplemented by experimental characterization of metabolic phenotypes in four isolates derived from the consortia. Measurements of isolate growth on the defined medium supplied with individual carbohydrates confirmed most of the predicted catabolic phenotypes. Not all consortia members use carbohydrates and only a few use complex polysaccharides suggesting a hierarchical carbon flow from cyanobacteria to

  6. Development of methanogenic consortia in fluidized-bed batches using sepiolite of different particle size.

    Science.gov (United States)

    Sánchez, J M; Rodríguez, F; Valle, L; Muñoz, M A; Moriñigo, M A; Borrego, J J

    1996-09-01

    The addition of support materials, such as sepiolite, to fluidized-bed anaerobic digesters enhances the methane production by increasing the colonization by syntrophic microbiota. However, the efficiency in the methanogenesis depends on the particle size of the support material, the highest level of methane production being obtained by the smaller particle size sepiolite. Because of the porosity and physico-chemical characteristics of these support materials, the anaerobic microbial consortia formed quickly (after one week of incubation). The predominant methanogenic bacteria present in the active granules, detected both by immunofluorescence using specific antibodies and by scanning electron microscopy, were acetoclastic methanogens, mainly Methanosarcina and Methanosaeta.

  7. The Process of Retirement Planning Scale (PRePS): development and validation.

    Science.gov (United States)

    Noone, Jack H; Stephens, Christine; Alpass, Fiona

    2010-09-01

    Although a substantial proportion of the western population is approaching retirement age, little is known about how they are preparing for the future. Much attention has been paid to the consumption of educational material and retirement wealth in the present literature, but the process of retirement planning has been ignored. S. L. Friedman and E. K. Scholnick's (1997) theoretical model provided the basis for a comprehensive measure of retirement planning. According to their process theory, individuals develop an understanding of the problem, set goals, make a decision to start preparing, and finally undertake the behaviors needed to fulfill their goals. Fifty-two items were developed to assess each stage of the planning process for financial, health, lifestyle, and psychosocial retirement planning. These were tested on a population sample of 1,449 New Zealanders aged 49-60. Confirmatory factor analysis, bivariate correlations, and hierarchical regression provided support for the valid use of the measure. Necessary antecedents, such as the tendency to look to the future, and locus of control were significantly related to the Process of Retirement Planning Scale (PRePS). The PRePS also outperformed retirement planning measures used in the Health and Retirement Study (F. T. Juster & R. Suzman, 1995) after controlling for socioeconomic and psychological variables. This measure will enable social policy makers to determine which stages of retirement planning require support and intervention. The PRePS will also help to determine which domains of retirement planning predict well-being in later life and the factors which differentiate those who are planning from those who are not.

  8. Fuzzy model investic do High-tech projektů

    Directory of Open Access Journals (Sweden)

    Alžběta Kubíčková

    2013-10-01

    Full Text Available Purpose of the article: Relations among parameters of High-tech projects are very complex, vague, partially inconsistent and multidimensional. Optimal decisions to invest into High-tech companies require top field experts and knowledgeable investors. Therefore the conventional methods of investments analysis are not relevant. Therefore fuzzy logic is introduced. Methodology/methods: A fuzzy knowledge base is a flexible framework for acquisition of vague inconsistent knowledge items which are typical for knowledge economics and consequently for High-tech projects. The pooling of the records and / or observations represents a trade-off between minimal modification of the original data and elimination of inconsistencies among available sets of data. Scientific aim: The paper presents a detailed description of fuzzy model of investment decision making into High-tech firm’s projects. A set of conditional statements was used to formalize the effects of selected variables on investment feasibility of High-tech projects. The main aim is to quantify feasibilities of High-tech projects risk investors make good /not bad decisions. Findings: A set of 50 observations of High-tech companies was transformed into a set of 50 conditional statements using 14 variables. The result is the fuzzy model, which can be used to answer investors’ queries. Two queries are answered and presented in details as an example and as a nucleus of a fuzzy dialogue investor – computer. Conclusions: The main problem is the sparseness of the fuzzy model. Many fuzzy similarities are relatively low and the decision process is therefore often problematic. A much more complex set of variables must be applied to specify the fuzzy model to increase reliability of predictions and decisions.

  9. Sexual Behavior, Risk Compensation, and HIV Prevention Strategies Among Participants in the San Francisco PrEP Demonstration Project: A Qualitative Analysis of Counseling Notes.

    Science.gov (United States)

    Carlo Hojilla, J; Koester, Kimberly A; Cohen, Stephanie E; Buchbinder, Susan; Ladzekpo, Deawodi; Matheson, Tim; Liu, Albert Y

    2016-07-01

    Pre-exposure prophylaxis (PrEP) is a viable HIV prevention strategy but risk compensation could undermine potential benefits. There are limited data that examine this phenomenon outside of clinical trials. We conducted a qualitative analysis of counseling notes from the San Francisco site of the US PrEP demonstration project to assess how men who have sex with men used PrEP as a prevention strategy and its impact on their sexual practices. Four major themes emerged from our analysis of 130 distinct notes associated with 26 participants. Prevention strategy decision-making was dynamic, often influenced by the context and perceived risk of a sexual encounter. Counselors noted that participants used PrEP in conjunction with other health promotion strategies like condoms, asking about HIV status of their sex partners, and seroadaptation. With few exceptions, existing risk reduction strategies were not abandoned upon initiation of PrEP. Risk-taking behavior was 'seasonal' and fluctuations were influenced by various personal, psychosocial, and health-related factors. PrEP also helped relieve anxiety regarding sex and HIV, particularly among serodiscordant partners. Understanding sexual decision-making and how PrEP is incorporated into existing prevention strategies can help inform future PrEP implementation efforts.

  10. Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study

    DEFF Research Database (Denmark)

    Schledermann, Doris; Hyldebrandt, Tina; Ejersbo, Dorthe;

    2007-01-01

    The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening ...

  11. Oral pre-exposure prophylaxis (PrEP) for prevention of HIV in serodiscordant heterosexual couples in the United States: opportunities and challenges.

    Science.gov (United States)

    McMahon, James M; Myers, Julie E; Kurth, Ann E; Cohen, Stephanie E; Mannheimer, Sharon B; Simmons, Janie; Pouget, Enrique R; Trabold, Nicole; Haberer, Jessica E

    2014-09-01

    Oral HIV pre-exposure prophylaxis (PrEP) is a promising new biomedical prevention approach in which HIV-negative individuals are provided with daily oral antiretroviral medication for the primary prevention of HIV-1. Several clinical trials have demonstrated efficacy of oral PrEP for HIV prevention among groups at high risk for HIV, with adherence closely associated with level of risk reduction. In the United States (US), three groups have been prioritized for initial implementation of PrEP-injection drug users, men who have sex with men at substantial risk for HIV, and HIV-negative partners within serodiscordant heterosexual couples. Numerous demonstration projects involving PrEP implementation among MSM are underway, but relatively little research has been devoted to study PrEP implementation in HIV-serodiscordant heterosexual couples in the US. Such couples face a unique set of challenges to PrEP implementation at the individual, couple, and provider level with regard to PrEP uptake and maintenance, adherence, safety and toxicity, clinical monitoring, and sexual risk behavior. Oral PrEP also provides new opportunities for serodiscordant couples and healthcare providers for primary prevention and reproductive health. This article provides a review of the critical issues, challenges, and opportunities involved in the implementation of oral PrEP among HIV-serodiscordant heterosexual couples in the US.

  12. An Exploratory Investigation of the Promoting Responsibility through Education and Prevention (PREP) after School Program for African American At-Risk Elementary School Students

    Science.gov (United States)

    Sale, Elizabeth; Weil, Virginia; Kryah, Rachel

    2012-01-01

    The promoting responsibility through education and prevention (PREP) program is an after school substance abuse and violence prevention program for at-risk fourth and fifth grade youths in St. Louis, Missouri. Staffed by licensed clinical social workers and professional volunteers, PREP offers cultural cooking classes, yoga, and art as well as…

  13. Numerical analysis on solidification process and heat transfer of FGH95 superalloy droplets during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming Chen; Benfu Hu; Yiwen Zhang; Quanmao Yu; Huiying Li

    2003-01-01

    In order to understand the relation between microstructure of superalloy powders and its solidification progress, the processing parameters are optimized during plasma rotating electrode processing (PREP). It was predicted from the results that the droplet velocities, droplet temperature, and fractional solidification with flight time about FGH95 superalloy droplet have been carried out based on Newtonian heat transfer formulation coupled with the classical heterogeneous nucleation and the specific solidification process. It has been found that the droplet dynamic and thermal behavior is strongly affected by the distribution of droplet diameters,the proportion of cooling atmosphere, but is relatively unaffected by the droplet superheat.

  14. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Directory of Open Access Journals (Sweden)

    Luís Miguel Rocha

    2014-11-01

    Full Text Available Introduction: Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013 were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods: A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results: A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%; those that were aware, had heard of it trough CheckpointLx (31%, internet (22% or health professionals (20%. 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%. Type of PrEP preferred was oral, a pill a day (43%, followed by oral, intermittent intake (32%. Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions: In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP, according to MSM Risk Index

  15. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Science.gov (United States)

    Miguel Rocha, Luís; José Campos, Maria; Brito, João; Fuertes, Ricardo; Rojas, Jesus; Pinto, Nuno; Mendão, Luís; Esteves, Julio

    2014-01-01

    Introduction Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%); those that were aware, had heard of it trough CheckpointLx (31%), internet (22%) or health professionals (20%). 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%). Type of PrEP preferred was oral, a pill a day (43%), followed by oral, intermittent intake (32%). Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP), according to MSM Risk Index in 2014 USA PrEP

  16. Effect of copper and lead on two consortia of phototrophic microorganisms and their capacity to sequester metals

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, A. [Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Edifici C, Campus de UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona (Spain); Departamento de Recursos Hidrobiológicos, Universidad de Nariño, Pasto (N) (Colombia); Maldonado, J. [Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Edifici C, Campus de UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona (Spain); De los Rios, A. [Museo Nacional de Ciencias Naturales(CSIC), Serrano 115 dpdo, 28006 Madrid (Spain); Solé, A. [Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Edifici C, Campus de UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona (Spain); Esteve, I., E-mail: isabel.esteve@uab.cat [Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Edifici C, Campus de UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona (Spain); Departamento de Recursos Hidrobiológicos, Universidad de Nariño, Pasto (N) (Colombia); Museo Nacional de Ciencias Naturales(CSIC), Serrano 115 dpdo, 28006 Madrid (Spain)

    2013-09-15

    Highlights: •We studied the tolerance-resistance of phototrophic microorganisms to copper and lead. •We determined the capacity of consortia of microorganisms to sequester copper and lead. •CLSM-λscan is a technique for evaluating in vivo effect of metals on microorganisms. •SEM-EDX and TEM-EDX determined the capacity of microorganisms to sequester metals. -- Abstract: The roles of consortia of phototrophic microorganisms have been investigated in this paper to determine their potential role to tolerate or resist metals and to capture them from polluted cultures. With this purpose, two consortia of microorganisms: on one hand, Geitlerinema sp. DE2011 (Ge) and Scenedesmus sp. DE2009 (Sc) (both identified in this paper by molecular biology methods) isolated from Ebro Delta microbial mats, and on the other, Spirulina sp. PCC 6313 (Sp) and Chroococcus sp. PCC 9106 (Ch), from Pasteur culture collection were polluted with copper and lead. In order to analyze the ability of these consortia to tolerate and capture metals, copper and lead were selected, because both have been detected in Ebro Delta microbial mats. The tolerance-resistance to copper and lead for both consortia was determined in vivo and at cellular level by Confocal Laser Scanning Microscopy (CLSM-λscan function). The results obtained demonstrate that both consortia are highly tolerant-resistant to lead and that the limits between the copper concentration having cytotoxic effect and that having an essential effect are very close in these microorganisms. The capacity of both consortia to capture extra- and intracellular copper and lead was determined by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) respectively, coupled to an Energy Dispersive X-ray detector (EDX). The results showed that all the microorganisms assayed were able to capture copper extracellularly in the extrapolymeric substances, and lead extra- and intracellularly in polyphosphate inclusions. Moreover

  17. Alcohol based surgical prep solution and the risk of fire in the operating room: a case report

    Directory of Open Access Journals (Sweden)

    Gupta Rajiv

    2008-04-01

    Full Text Available Abstract A few cases of fire in the operating room are reported in the literature. The factors that may initiate these fires are many and include alcohol based surgical prep solutions, electrosurgical equipment, flammable drapes etc. We are reporting a case of fire in the operating room while operating on a patient with burst fracture C6 vertebra with quadriplegia. The cause of the fire was due to incomplete drying of the covering drapes with an alcohol based surgical prep solution. This paper discusses potential preventive measures to minimize the incidence of fire in the operating room.

  18. Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature.

    Science.gov (United States)

    Koechlin, Florence M; Fonner, Virginia A; Dalglish, Sarah L; O'Reilly, Kevin R; Baggaley, Rachel; Grant, Robert M; Rodolph, Michelle; Hodges-Mameletzis, Ioannis; Kennedy, Caitlin E

    2016-11-29

    Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP. A comprehensive search strategy reviewed three electronic databases of articles and HIV-related conference abstracts (January 1990-April 2015). Data abstraction used standardised forms to categorise by population groups and relevant themes. Of 3068 citations screened, 76 peer-reviewed articles and 28 conference abstracts were included. Geographic coverage was global. Most studies (N = 78) evaluated hypothetical use of PrEP, while 26 studies included individuals who actually took PrEP or placebo. Awareness of PrEP was low, but once participants were presented with information about PrEP, the majority said they would consider using it. Concerns about safety, side effects, cost and effectiveness were the most frequently cited barriers to use. There was little indication of risk compensation. Healthcare providers would consider prescribing PrEP, but need more information before doing so. Findings from a rapidly expanding evidence base suggest that the majority of populations most likely to benefit from PrEP feel positively towards it. These same populations would benefit from overcoming current implementation challenges with the shortest possible delay.

  19. Complex and Conflicting Social Norms: Implications for Implementation of Future HIV Pre-Exposure Prophylaxis (PrEP Interventions in Vancouver, Canada.

    Directory of Open Access Journals (Sweden)

    Rod Knight

    Full Text Available HIV Pre-Exposure Prophylaxis (PrEP has been found to be efficacious in preventing HIV acquisition among seronegative individuals in a variety of risk groups, including men who have sex with men and people who inject drugs. To date, however, it remains unclear how socio-cultural norms (e.g., attitudes towards HIV; social understandings regarding HIV risk practices may influence the scalability of future PrEP interventions. The objective of this study is to assess how socio-cultural norms may influence the implementation and scalability of future HIV PrEP interventions in Vancouver, Canada.We conducted 50 interviews with young men (ages 18-24 with a variety of HIV risk behavioural profiles (e.g., young men who inject drugs; MSM. Interviews focused on participants' experiences and perceptions with various HIV interventions and policies, including PrEP.While awareness of PrEP was generally low, perceptions about the potential personal and public health gains associated with PrEP were interconnected with expressions of complex and sometimes conflicting social norms. Some accounts characterized PrEP as a convenient form of reliable protection against HIV, likening it to the female birth control pill. Other accounts cast PrEP as a means to facilitate 'socially unacceptable' behaviour (e.g., promiscuity. Stigmatizing rhetoric was used to position PrEP as a tool that could promote some groups' proclivities to take 'risks'.Stigma regarding 'risky' behaviour and PrEP should not be underestimated as a serious implementation challenge. Pre-implementation strategies that concomitantly aim to improve knowledge about PrEP, while addressing associated social prejudices, may be key to effective implementation and scale-up.

  20. Enhanced Biocide Mitigation of Field Biofilm Consortia by a Mixture of D-Amino Acids

    Science.gov (United States)

    Li, Yingchao; Jia, Ru; Al-Mahamedh, Hussain H.; Xu, Dake; Gu, Tingyue

    2016-01-01

    Microbiologically influenced corrosion (MIC) is a major problem in the oil and gas industry as well as in many other industries. Current treatment methods rely mostly on pigging and biocide dosing. Biocide resistance is a growing concern. Thus, it is desirable to use biocide enhancers to improve the efficacy of existing biocides. D-Amino acids are naturally occurring. Our previous work demonstrated that some D-amino acids are biocide enhancers. Under a biocide stress of 50 ppm (w/w) hydroxymethyl phosphonium sulfate (THPS) biocide, 1 ppm D-tyrosine and 100 ppm D-methionine used separately successfully mitigated the Desulfovibrio vulgaris biofilm on carbon steel coupons. The data reported in this work revealed that 50 ppm of an equimolar mixture of D-methionine, D-tyrosine, D-leucine, and D-tryptophan greatly enhanced 50 ppm THPS biocide treatment of two recalcitrant biofilm consortia containing sulfate reducing bacteria (SRB), nitrate reducing bacteria (NRB), and fermentative bacteria, etc., from oil-field operations. The data also indicated that individual D-amino acids were inadequate for the biofilm consortia. PMID:27379039

  1. Revealing characteristics of mixed consortia for azo dye decolorization: Lotka-Volterra model and game theory.

    Science.gov (United States)

    Chen, Bor-Yann

    2007-10-22

    This study provides a novel explanation to put forward, in Lotka-Volterra competition model and game theory, interspecific competition in bioaugmentation using constructed mixed consortia for azo dye decolorization. As mixed cultures are regularly used in industrial dye-laden wastewater treatment, understanding species competition of mixed consortia is apparently of great importance to azo dye decolorization. In aerobic growth conditions, Escherichia coli DH5alpha owned a growth advantage to out-compete Pseudomonas luteola due to preferential growth rate of DH5alpha. However, in static decolorization conditions DH5alpha surrendered some proportion of its advantage (i.e., a decrease in its competitive power for metabolite stimulation) to enhance color removal of P. luteola for total coexistence. In aerobic growth, DH5alpha had its growth advantage to exclude P. luteola for dominance (i.e, conflict strategy) according to competitive exclusion principle. In static decolorization conditions, as the removal of a common dye threat was crucial to both species for survival, both species selected cooperation strategy through metabolite stimulation of DH5alpha to enhance effective decolorization of P. luteola for long-term sustainable management. This analysis of game theory clearly unlocked unsolved mysteries in previous studies.

  2. Enhanced Biocide Mitigation of Field Biofilm Consortia by a Mixture of D-Amino Acids.

    Science.gov (United States)

    Li, Yingchao; Jia, Ru; Al-Mahamedh, Hussain H; Xu, Dake; Gu, Tingyue

    2016-01-01

    Microbiologically influenced corrosion (MIC) is a major problem in the oil and gas industry as well as in many other industries. Current treatment methods rely mostly on pigging and biocide dosing. Biocide resistance is a growing concern. Thus, it is desirable to use biocide enhancers to improve the efficacy of existing biocides. D-Amino acids are naturally occurring. Our previous work demonstrated that some D-amino acids are biocide enhancers. Under a biocide stress of 50 ppm (w/w) hydroxymethyl phosphonium sulfate (THPS) biocide, 1 ppm D-tyrosine and 100 ppm D-methionine used separately successfully mitigated the Desulfovibrio vulgaris biofilm on carbon steel coupons. The data reported in this work revealed that 50 ppm of an equimolar mixture of D-methionine, D-tyrosine, D-leucine, and D-tryptophan greatly enhanced 50 ppm THPS biocide treatment of two recalcitrant biofilm consortia containing sulfate reducing bacteria (SRB), nitrate reducing bacteria (NRB), and fermentative bacteria, etc., from oil-field operations. The data also indicated that individual D-amino acids were inadequate for the biofilm consortia.

  3. Enzymatic bioremediation of polyaromatic hydrocarbons by fungal consortia enriched from petroleum contaminated soil and oil seeds.

    Science.gov (United States)

    Balaji, V; Arulazhagan, P; Ebenezer, P

    2014-05-01

    The present study focuses on fungal strains capable of secreting extracellular enzymes by utilizing hydrocarbons present in the contaminated soil. Fungal strains were enriched from petroleum hydrocarbons contaminated soil samples collected from Chennai city, India. The potential fungi were isolated and screened for their enzyme secretion such as lipase, laccase, peroxidase and protease and also evaluated fungal enzyme mediated PAHs degradation. Total, 21 potential PAHs degrading fungi were isolated from PAHs contaminated soil, which belongs to 9 genera such as Aspergillus, Curvularia, Drechslera, Fusarium, Lasiodiplodia, Mucor Penicillium, Rhizopus, Trichoderma, and two oilseed-associated fungal genera such as Colletotrichum and Lasiodiplodia were used to test their efficacy in degradation of PAHs in polluted soil. Maximum lipase production was obtained with P. chrysogenum, M. racemosus and L. theobromae VBE1 under optimized cultural condition, which utilized PAHs in contaminated soil as sole carbon source. Fungal strains, P. chrysogenum, M. racemosus and L. theobromae VBE1, as consortia, used in the present study were capable of degrading branched alkane isoprenoids such as pristine (C17) and pyrene (C18) present in PAHs contaminated soil with high lipase production. The fungal consortia acts as potential candidate for bioremediation of PAHs contaminated environments.

  4. Do the shuffle: Changes in Symbiodinium consortia throughout juvenile coral development

    Science.gov (United States)

    Reich, Hannah G.; Robertson, Deborah L.; Goodbody-Gringley, Gretchen

    2017-01-01

    Previous studies of symbiotic associations between scleractinians corals and Symbiodinium have demonstrated that the consortium of symbionts can change in response to environmental conditions. However, less is known about symbiont shuffling during early coral development, particularly in brooding species. This study examined whether Symbiodinium consortia (1) varied in Porites astreoides on shallow (10m) and upper mesophotic (30m) reefs, (2) changed during coral development, and (3) influenced growth of juveniles in different environments. Symbiodinium ITS2 sequences were amplified using universal primers and analyzed using phylotype-specific primers designed for phylotypes A, B, and C. Adults from both depths were found to host only phylotype A, phylotypes A and B, or phylotypes A, B, and C and the frequency of the phylotype composition did not vary with depth. However, phylotype A was the dominant symbiont that was vertically transmitted to the planulae. The presence of phylotypes B and C was detected in the majority of juveniles when transplanted onto the shallow and upper mesophotic reefs whereas only phylotype A was detected in the majority of juveniles reared in outdoor aquaria. In addition, growth of juvenile P. astreoides harboring different combinations of Symbiodinium phylotypes did not vary when transplanted to different reef zones. However, juveniles reared in in situ reef environments grew faster than those reared in ex situ outdoor aquaria. These results show that Symbiodinium consortia change during development of P. astreoides and are influenced by environmental conditions. PMID:28182684

  5. Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media.

    Science.gov (United States)

    Pęziak, Daria; Piotrowska, Aleksandra; Marecik, Roman; Lisiecki, Piotr; Woźniak, Marta; Szulc, Alicja; Ławniczak, Łukasz; Chrzanowski, Łukasz

    2013-01-01

    The aim of our study was to investigate the effect of Triton X-100 on the biodegradation efficiency of hexadecane and phenanthrene carried out by two bacterial consortia. It was established that the tested consortia were not able to directly uptake compounds closed in micelles. It was observed that in micellar systems the nonionic synthetic surfactant was preferentially degraded (the degradation efficiency of Triton X-100 after 21 days was 70% of the initial concentration - 500 mg/l), followed by a lesser decomposition of hydrocarbon released from the micelles (30% for hexadecane and 20% for phenanthrene). However, when hydrocarbons were used as the sole carbon source, 70% of hexadecane and 30% of phenanthrene were degraded. The degradation of the surfactant did not contribute to notable shifts in bacterial community dynamics, as determined by Real-Time PCR. The obtained results suggest that if surfactant-supplementation is to be used as an integral part of a bioremediation process, then possible bioavailability decrease due to entrapment of the contaminant into surfactant micelles should also be taken into consideration, as this phenomenon may have a negative impact on the biodegradation efficiency. Surfactant-induced mobilization of otherwise recalcitrant hydrocarbons may contribute to the spreading of contaminants in the environment and prevent their biodegradation.

  6. Eco prep: the economical preparation of ceramic bodies; Ecoprep: la preparacion rentable de masas ceramicas

    Energy Technology Data Exchange (ETDEWEB)

    Luders, M.; Walter, H. J.; Nold, P.; Lobe, R.; Muller, M.; Gerl, S.

    2012-07-01

    Eco prep (Economic Preparation) is the sustainable technology for preparing ceramic bodies with a minimum consumption of resources. It has a huge impact on the energy balance and eliminates the need for additives to generate a high-quality slip to make granules. In consequence Eco prep delivers a significant reduction in production costs, bringing an investment in this technology to the break-even point after a very short time. Reduction in water consumption and additives and the use of new raw materials are other advantages that impulse the implementation of this production technology, as well as important reduction of CO{sub 2} emissions, contributing to meeting the goals of the Kyoto Protocol. In short: A technology already successfully applied in different industries for decades, that includes a compendium of measures based on saving reductions in a range from 66% (energy, water,) and 100% (additives, deflocculants, etc.) and will mark the future in micro granulation processes also in the ceramic industry. (Author)

  7. The PREP pipeline: standardized preprocessing for large-scale EEG analysis.

    Science.gov (United States)

    Bigdely-Shamlo, Nima; Mullen, Tim; Kothe, Christian; Su, Kyung-Min; Robbins, Kay A

    2015-01-01

    The technology to collect brain imaging and physiological measures has become portable and ubiquitous, opening the possibility of large-scale analysis of real-world human imaging. By its nature, such data is large and complex, making automated processing essential. This paper shows how lack of attention to the very early stages of an EEG preprocessing pipeline can reduce the signal-to-noise ratio and introduce unwanted artifacts into the data, particularly for computations done in single precision. We demonstrate that ordinary average referencing improves the signal-to-noise ratio, but that noisy channels can contaminate the results. We also show that identification of noisy channels depends on the reference and examine the complex interaction of filtering, noisy channel identification, and referencing. We introduce a multi-stage robust referencing scheme to deal with the noisy channel-reference interaction. We propose a standardized early-stage EEG processing pipeline (PREP) and discuss the application of the pipeline to more than 600 EEG datasets. The pipeline includes an automatically generated report for each dataset processed. Users can download the PREP pipeline as a freely available MATLAB library from http://eegstudy.org/prepcode.

  8. Houston Pre-Freshman Enrichment Program (Houston PREP). Final report, June 9, 1997--July 25, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The 1997 Houston Pre-Freshman Enrichment Program (PREP) was conducted at the campus of the University of Houston-Downtown from June 9 to July 25, 1997. Program participants were recruited from the Greater Houston Area. All participants were identified as high-achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Clear Creek, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 194 students starting the program, 165 students were from economically and socially disadvantage groups under-represented in the engineering and science professions, and 118 of the 194 were women. Our First Year group for 1997 composed of 96% minority and women students. Second and Third Year students combined were 96% minority or women. With financial support from the Center for Computational Sciences and Advanced Distributed Simulation, the Fourth Year Program was added to PREP this year. Twelve students completed the program (83% minority or women).

  9. Virginia Tech's K-9 unit to receive Kevlar vest from alumni organization

    OpenAIRE

    Dickerson, Susan

    2004-01-01

    Hokie, the Virginia Tech Police Department's German shepherd, will be presented with a custom-fitted Virginia Tech Kevlar bulletproof vest to protect him from all the dangers he faces while performing his daily duties.

  10. 78 FR 14359 - Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA...

    Science.gov (United States)

    2013-03-05

    ... Employment and Training Administration Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA; Verizon Business Networks Services, Inc., Specialist-Tech Customer Service..., 2012, applicable to workers of Verizon Business Networks Services, Inc., Order Management...

  11. Arquitectura low tech. Refugio de emergencia con palets

    OpenAIRE

    Borreguero Sánchez, Laura

    2015-01-01

    Este estudio busca profundizar en una alternativa a la arquitectura actual rescatando materiales y técnicas que han sido utilizadas a lo largo de la historia pero que debido a las nuevas tecnologías se han ido perdiendo. Esta “nueva” forma de construir se conoce como arquitectura Low Tech. Así, Low Tech hace referencia a una arquitectura que no precisa de una gran tecnología y que se sirve de materiales y técnicas propios de cada lugar haciendo de éste un sistema económico e...

  12. Displacement in new economy labor markets: Post-displacement wage loss in high tech versus low tech cities.

    Science.gov (United States)

    Davis, Daniel J; Rubin, Beth A

    2016-11-01

    While scholars and politicians tout education as the salve to employment disruptions, we argue that the geography of the new economy, and the social closure mechanisms that geography creates, may be just as important as individuals' characteristics for predicting post-displacement wage loss (or gain). We use data from the 2012 Displaced Workers ement of the Current Population Survey and from the 2010 United States Census to test hypotheses linking local labor markets in different industrial contexts to post-displacement wage loss. Our results point to age as a closure mechanism, and to the partially protective effect of education in high-tech versus low-tech economic sectors. This study is the first to use national level data to examine how employment in high-tech cities influences post-displacement wages. These findings are relevant both for theorizing about the new economy and for public policy. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. High-tech exports from developing countries: A symptom of technology spurts or statistical illusion?

    OpenAIRE

    Martin Srholec

    2005-01-01

    Specialization in high-tech products is frequently used to capture technology intensity of exports. The literature suggests that developing countries are increasingly becoming exporters of high-tech products, and some may even be among the most deeply specialized countries in the field of high-tech exports. The paper scrutinizes the relevance of the taxonomies that classify exports by technological intensity in this context. It is shown that specialization in high-tech exports typically does ...

  14. Standard Tools for Measuring Post Implementation TECH MOD (Technology Modernization) Cost Savings.

    Science.gov (United States)

    2014-09-26

    Another con- tractor developed a formula based on the Cost Performance Report ( CPR ) which provides unit cost savings. The final contractor measured...DEPARTMENT OF DEFENSE INITIATIVES ........... 2 C. TECH MOD HISTORY ............ ...... ......... 3 D. THE TECH MOD PROCESS ........... ............ 4...Guide 4 Oct 1984). C. TECH MOD HISTORY The first Tech Mod planning started in late 1970 with the F-16 program and the need to improve the government

  15. Toward a "Common Definition of English Learner": A Brief Defining Policy and Technical Issues and Opportunities for State Assessment Consortia

    Science.gov (United States)

    Linquanti, Robert; Cook, H. Gary

    2013-01-01

    The U.S. Department of Education (USED) requires states participating in either of the two Race to the Top assessment consortia (Smarter Balanced Assessment Consortium and Partnership for Assessment of Readiness for College and Careers [PARCC]), as well as those participating in either of the two Enhanced Assessment Grant (EAG) English language…

  16. Phototrophic Biofilm Assembly in Microbial-Mat-Derived Unicyanobacterial Consortia: Model Systems for the Study of Autotroph-Heterotroph Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Jessica K.; Hutchison, Janine R.; Renslow, Ryan S.; Kim, Young-Mo; Chrisler, William B.; Engelmann, Heather E.; Dohnalkova, Alice; Hu, Dehong; Metz, Thomas O.; Fredrickson, Jim K.; Lindemann, Stephen R.

    2014-04-07

    Though microbial autotroph-heterotroph interactions influence biogeochemical cycles on a global scale, the diversity and complexity of natural systems and their intractability to in situ environmental manipulation makes elucidation of the principles governing these interactions challenging. Examination of primary succession during phototrophic biofilm assembly provides a robust means by which to elucidate the dynamics of such interactions and determine their influence upon recruitment and maintenance of phylogenetic and functional diversity in microbial communities. We isolated and characterized two unicyanobacterial consortia from the Hot Lake phototrophic mat, quantifying the structural and community composition of their assembling biofilms. The same heterotrophs were retained in both consortia and included members of Alphaproteobacteria, Gammaproteobacteria, and Bacteroidetes, taxa frequently reported as consorts of microbial photoautotrophs. Cyanobacteria led biofilm assembly, eventually giving way to a late heterotrophic bloom. The consortial biofilms exhibited similar patterns of assembly, with the relative abundances of members of Bacteroidetes and Alphaproteobacteria increasing and members of Gammaproteobacteria decreasing as colonization progressed. Despite similar trends in assembly at higher taxa, the consortia exhibited substantial differences in community structure at the species level. These similar patterns of assembly with divergent community structures suggest that, while similar niches are created by the metabolism of the cyanobacteria, the resultant webs of autotroph-heterotroph and heterotroph-heterotroph interactions driving metabolic exchange are specific to each primary producer. Altogether, our data support these Hot Lake unicyanobacterial consortia as generalizable model systems whose simplicity and tractability permit the deciphering of community assembly principles relevant to natural microbial communities.

  17. Realizing Student, Faculty, and Institutional Outcomes at Scale: Institutionalizing Undergraduate Research, Scholarship, and Creative Activity within Systems and Consortia

    Science.gov (United States)

    Malachowski, Mitchell; Osborn, Jeffrey M.; Karukstis, Kerry K.; Ambos, Elizabeth L.

    2015-01-01

    This chapter reviews the evidence for the effectiveness of undergraduate research as a student, faculty, and institutional success pathway, and provides the context for the Council on Undergraduate Research's support for developing and enhancing undergraduate research in systems and consortia. The chapter also provides brief introductions to each…

  18. 25 CFR 1000.15 - How many additional Tribes/Consortia may participate in self-governance per year?

    Science.gov (United States)

    2010-04-01

    ... self-governance per year? 1000.15 Section 1000.15 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN... Participation in Tribal Self-Governance Eligibility § 1000.15 How many additional Tribes/Consortia may participate in self-governance per year? (a) Sections 402(b) and (c) of the Act authorize the Director...

  19. Cost-effectiveness of PrEP in HIV/AIDS control in Zambia: a stochastic league approach

    NARCIS (Netherlands)

    Nichols, B.E.; Baltussen, R.M.; Dijk, J.H. van; Thuma, P.E.; Nouwen, J.L.; Boucher, C.A.B.; Vijver, D.A. van de

    2014-01-01

    BACKGROUND: Earlier antiretroviral therapy initiation and pre-exposure prophylaxis (PrEP) prevent HIV, although at a substantial cost. We use mathematical modeling to compare the cost-effectiveness and economic affordability of antiretroviral-based prevention strategies in rural Macha, Zambia.

  20. Vulnerable infected populations and street markets for ARVs: Potential implications for PrEP rollout in the USA.

    Science.gov (United States)

    Kurtz, Steven P; Buttram, Mance E; Surratt, Hilary L

    2014-04-01

    Widespread diversion of antiretroviral (ARV) medications to illicit markets has recently been documented among indigent patients in South Florida. The recent approval of ARVs for pre-exposure prophylaxis (PrEP) has the potential to broaden these illicit markets, as high-risk individuals seek ARVs without a prescription or medical supervision. Nonadherence among diverters and unsupervised use of ARVs for treatment or PrEP increase risks of treatment failure, drug resistance, and disease transmission. We report the scope of ARV diversion among substance-using men who have sex with men in South Florida. Structured interviews (N = 515) queried demographics, HIV status, mental distress, substance dependence, and sexual risks. HIV-positive participants answered questions about medical care, treatment, and ARV adherence and diversion. Median age was 39. Of 46.4% who were HIV-positive, 79.1% were prescribed ARVs. Of these, 27% reported selling/trading ARVs. Reasons for diversion were sharing/trading with friends, sale/trade for money/drugs, and sale/trade of unused medications. ARV diverters, compared to nondiverters, were more likely to be substance dependent (74.5% vs. 58.7%, p = 0.046) and have traded sex for money/drugs (60.8% vs. 32.6%, p system. The implications of diversion for increased risks of treatment failure, disease transmission, and PrEP failure should be carefully considered in developing policy and behavioral supports to scaling up treatment as prevention and PrEP.

  1. Saying 'No' to PrEP research in Malawi: what constitutes 'failure' in offshored HIV prevention research?

    Science.gov (United States)

    Peterson, Kristin; Folayan, Morenike Oluwatoyin; Chigwedere, Edward; Nthete, Evaristo

    2015-12-01

    Between 2004 and 2005, the first multi-sited clinical trial tested whether an existing, marketed antiretroviral drug, Tenofovir (TDF), could prevent HIV transmission. Referred to as pre-exposure prophylaxis (PrEP), most of these trial sites prematurely closed down. Two sites located in Cambodia and Cameroon received international media attention. But little attention was drawn to sites in Malawi and Nigeria, where university ethicists and research scientists extensively debated PrEP. This article focuses on events that took place in Malawi where there was a prolonged dispute over the scientific rationales of PrEP and not trial specific ethics referred to as 'bioethics'. Specifically, the article discusses debates pertaining to three PrEP trial protocols that were refused ethics approval in Malawi between 2004 and 2009. It is argued that HIV science debates in Malawi are embedded in postcolonial politics--geopolitical histories and state and household economic dispossessions that have created the structural possibilities for Malawi to become an offshore destination for HIV clinical research. As such, ethics in this case does not pertain to trial or bioethical 'failures'. Rather, ethics is located at the scale of imperial relations that give rise to multiple, often invisible, research concerns and constraints.

  2. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP in clinical settings to prevent HIV infection.

    Directory of Open Access Journals (Sweden)

    Emily A Arnold

    Full Text Available BACKGROUND: A recent clinical trial demonstrated that a daily dose tenofovir disoproxil fumarate and emtricitabrine (TDF-FTC can reduce HIV acquisition among men who have sex with men (MSM and transgender (TG women by 44%, and up to 90% if taken daily. We explored how medical and service providers understand research results and plan to develop clinical protocols to prescribe, support and monitor adherence for patients on PrEP in the United States. METHODS: Using referrals from our community collaborators and snowball sampling, we recruited 22 healthcare providers in San Francisco, Oakland, and Los Angeles for in-depth interviews from May-December 2011. The providers included primary care physicians seeing high numbers of MSM and TG women, HIV specialists, community health clinic providers, and public health officials. We analyzed interviews thematically to produce recommendations for setting policy around implementing PrEP. Interview topics included: assessing clinician impressions of PrEP and CDC guidance, considerations of cost, office capacity, dosing schedules, and following patients over time. RESULTS: Little or no demand for PrEP from patients was reported at the time of the interviews. Providers did not agree on the most appropriate patients for PrEP and believed that current models of care, which do not involve routine frequent office visits, were not well suited for prescribing PrEP. Providers detailed the need to build capacity and were concerned about monitoring side effects and adherence. PrEP was seen as potentially having impact on the epidemic but providers also noted that community education campaigns needed to be tailored to effectively reach specific vulnerable populations. CONCLUSIONS: While PrEP may be a novel and clinically compelling prevention intervention for MSM and TG women, it raises a number of important implementation challenges that would need to be addressed. Nonetheless, most providers expressed optimism that

  3. Regional Library Consortia in Western Mainland of Taiwan Strait%海峡西岸区域图书馆联盟体建设探究

    Institute of Scientific and Technical Information of China (English)

    欧阳红红

    2011-01-01

    建设海峡西岸区域图书馆联盟体是与国家战略规划相适应的举措。基于对专业图书馆联盟、区域图书馆联盟等联盟模式的研究与分析,确立联盟体所具有的管理中心、分中心和成员馆三级体系结构,提出同系统、同专业和跨系统图书馆联盟分步建设的新策略,最后讨论联盟体的主要任务和服务。%Building the regional library consortia in western mainland of Taiwan Strait is compatible with the national strategic planning. On the basis of researches and analyses on the pattern of professional library consortia and regional library consortia, the author establishes a three lever structure of library consortia which contains management center, sub-centers and members of the consortia. The author puts forward that constructing the regional library consortia in same system, in same profession and in cross-system step by step, and discusses the main tasks and services of the consortia of library in western mainland of Taiwan Strait.

  4. Conversion of ammonia-pretreated switchgrass to biofuel precursors by bacterial-fungal consortia under solid-state and submerged-state cultivation.

    Science.gov (United States)

    Jain, A; Pelle, H S; Baughman, W H; Henson, J M

    2017-04-01

    The aim of this study was to develop and evaluate bacterial-fungal communities to deconstruct switchgrass to biofuel precursors. Bacterial-fungal consortia, mesophilic (25°C) and thermophilic (50°C), were enriched from switchgrass bales from which enzyme mixtures were used to deconstruct delignified switchgrass (DSG). The bacterial-fungal consortia were able to produce enzymes including endoglucanase, exoglucanase, β-glucosidase, xylanase, xylosidase and pectinase to convert DSG to soluble carbohydrates. 454 pyrosequencing revealed that Paenibacillus and Streptomyces were the dominant bacteria in the mesophilic and thermophilic consortia respectively. Penicillium and Acremonium were the dominant fungi in the mesophilic consortia, whereas Aspergillus and Penicillium were the dominant fungi present in the thermophilic consortia. The results show that the state of cultivation, solid-state or submerged-state, affects the community structure as well as enzyme activities produced by these bacterial-fungal consortia. The enzyme mixture produced by the bacterial-fungal consortia released a higher amount of xylose than glucose during saccharification of DSG. The study provides a novel approach to produce enzymes for conversion of lignocellulolytic feedstocks to soluble sugars which can be used to produce biofuel precursors. © 2016 The Society for Applied Microbiology.

  5. Introduction of the Thin Prep Imaging System™ (TIS: experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-02-01

    Full Text Available Abstract Objective Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women's Hospital. We introduced the TIS in December 2004. Methods The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003–November 2004 are taken as the historic control group for our study. Results The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022. The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  6. CareerTech VISION 2012--Transforming CTE Together

    Science.gov (United States)

    Bray, Janet B.

    2012-01-01

    As the leader in career and technical education (CTE), the Association for Career and Technical Education (ACTE) understands the ongoing challenges faced by the CTE community. That is why ACTE has created CareerTech VISION 2012, a bold and visionary event that addresses the evolving needs of the global society and meets all individual and…

  7. Educating Students to Boost Innovation and High-tech Entrepreneurship

    DEFF Research Database (Denmark)

    Berg, Rolf Henrik

    Promoting innovative thinking among students is crucial to educating the workforce necessary for innovation-led economies. And high-tech entrepreneurs are a crucial source of creating new jobs. Innovation is not an exact discipline or a system one can just implement. By contrast, it is very much...

  8. Job Future's Bright for the Chefs of Muskingum Tech.

    Science.gov (United States)

    Hoffman, Carl

    1993-01-01

    A two-year culinary arts program at Muskingum College (Zanesville, Ohio) prepares students for jobs in an emerging service-based economy. Students receive intensive classroom instruction and hands-on learning in a high-tech kitchen. Twenty-five full-time and 12 part-time students are completing their first year in the program. (LP)

  9. High Touch in a High-Tech World

    Science.gov (United States)

    Gibson, Cindy L.

    2009-01-01

    In a world of high tech and low touch, it is easy for public relations programs to stray from tried-and-true interpersonal strategies long associated with solid communication planning. New technologies allow communications professionals to quickly send e-mails and telephone calls to selected groups. Social media sites provide users immediate…

  10. Virginia Tech study reveals predation-evolution link

    OpenAIRE

    Trulove, Susan

    2007-01-01

    The fossil record seems to indicate that the diversity of marine creatures increased and decreased over hundreds of millions of years in step with predator-prey encounters, Virginia Tech geoscientists report in the proceedings of the National Academy of Science online early edition the week of Sept. 10.

  11. NASA Consortium awards funding to Virginia Tech's geospatial program

    OpenAIRE

    Davis, Lynn

    2004-01-01

    NASA has selected a partnership between the Virginia Space Grant Consortium (VSGC) and Virginia Tech to receive a $100,000 grant for geospatial education and work force development. The grant, awarded through the NASA Space Grant College and Fellowship program, allows the partners to continue the already successful Virginia Geospatial Extension Program that was established in July 2003.

  12. Functional Dyes, and Some Hi-Tech Applications

    Directory of Open Access Journals (Sweden)

    Reda M. El-Shishtawy

    2009-01-01

    Full Text Available An overview of the recent developments in functional dyes, which are useful for hi-tech applications for those based on optoelectronics, such as dye sensitized solar cells, photochromic dyes and biomedical applications, such as photodynamic therapy for the treatment of cancer and fluorescent sensors is presented.

  13. Asia's New High-Tech Competitors: An SRS Special Report.

    Science.gov (United States)

    Rausch, Lawrence M.

    This report profiles nine economies linked by Asian identity, yet marked by great economic and technological disparity, in order to project which economies will be full-fledged participants and competitors in tomorrow's high-tech product markets. Based on the various indicators of technological activity and competitiveness presented in this…

  14. Ten Niche Strategies To Commercialize New High-Tech Products

    NARCIS (Netherlands)

    Ortt, J.R.; Langley, D.J.; Pals, N.

    2013-01-01

    There are serious gaps in the scientific literature relating to niche strategies as a means for commercializing new high-tech products. In particular, there is no clarity about what types of niche strategies can be distinguished, or how a niche strategy can be selected to suit a certain ituation. In

  15. Virginia Tech to host Biodiversity Conservation in Agriculture Symposium

    OpenAIRE

    Felker, Susan B.

    2006-01-01

    Virginia Tech will host the Biodiversity Conservation in Agriculture Symposium at its Caribbean Center for Education and Research in Punta Cana, the Dominican Republic, May 31 - June 2. The symposium is designed to promote inclusion of biodiversity conservation objectives in agricultural development activities.

  16. Virginia Tech administrator receives award from Philippine government

    OpenAIRE

    2004-01-01

    Philippine President Gloria Macapagal Arroyo has honored S. K. De Datta of Blacksburg, associate provost for international affairs at Virginia Tech, with a Presidential Citation Award. The award recognizes De Datta's contributions towards eradicating hunger through improved agricultural productivity and food security, particularly for the production of rice.

  17. Virginia Tech to compete in 2009 Solar Decathlon

    OpenAIRE

    Chadwick, Heather Riley

    2008-01-01

    The U.S. Department of Energy has announced that Virginia Tech will be one of 20 university teams selected to compete in its fourth Solar Decathlon, which will be held on the National Mall in Washington, D.C., in the fall of 2009.

  18. Virginia Tech team places fourth at Solar Decathlon 2005

    OpenAIRE

    Chadwick, Heather Riley

    2005-01-01

    A house designed and built by a team of students from Virginia Tech's College of Architecture and Urban Studies and College of Engineering placed fourth overall on Friday, Oct. 14, at Solar Decathlon 2005, an international competition sponsored by the Department of Energy held on the Mall in Washington, D.C.

  19. Suzhou Institute of Nano-tech and Nano-bionics

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The Suzhou Institute of Nano-tech and Nano-bionics is co-established by CAS, the provincial government of Jiangsu, and the municipal government of Suzhou, a time-honored urban center and picturesque tourist resort in the Yangtze delta.

  20. A new partnership: joint ventures and high-tech imaging.

    Science.gov (United States)

    Rutherford, R M

    1987-01-01

    Today joint ventures are a viable option for acquiring high-tech, high-priced imaging equipment. In this article based on his RSNA Associated Sciences presentation, Mr. Rutherford discusses a variety of issues concerning joint ventures: planning, tax considerations, structure and the ethics question.

  1. ASM International : Family tech enterprise grows up: Part A

    NARCIS (Netherlands)

    Lachotzki, F.W.I.; Schuit, S.R.; Olson, M.A.

    2012-01-01

    High-tech innovation is something not confined to the US, and indeed for decades the Dutch-based company ASMI has been a strong worldwide competitor in the market for the highly-complicated machines which manufacture the semi-conducter chips which are to be found in all modern-day electronic devices

  2. Employment and Earnings in High-Tech Ethnic Niches

    Science.gov (United States)

    Lee, Jennifer C.

    2013-01-01

    The increase in high-skilled immigrants to the United States coincided with the expansion of the high-technology sector, and now a large share of Asian immigrants concentrate in high-tech industries. Despite much research on the relationship between ethnic concentration and labor market outcomes, the association between ethnic niche employment and…

  3. Business, industry, government preview energy research at Virginia Tech Showcase

    OpenAIRE

    Felker, Susan B.

    2006-01-01

    The Nov. 29-30 Energy Research Engagement Showcase offers business and community leaders the opportunity to learn about more than 300 energy-related activities at Virginia Tech, as well as energy efforts by faculty members at other public universities in Virginia.

  4. Examination of the New Tech Model as a Holistic Democracy

    Science.gov (United States)

    Bradley-Levine, Jill; Mosier, Gina

    2017-01-01

    Using the Degrees of Democracy Framework (Woods & Woods, 2012), we examined eight New Tech (NT) high schools to determine the extent to which they demonstrated characteristics of holistic democracy. We collected qualitative data, including observations and interviews during the fourth year of implementation. Findings indicated that the eight…

  5. CHARCOAL PACKED FURNACE FOR LOW-TECH CHARRING OF BONE

    DEFF Research Database (Denmark)

    Jacobsen, P.; Dahi, Elian

    1997-01-01

    A low-tech furnace for charring of raw bone using char coal is developed and tested. The furnace consists of a standard oil drum, fitted with simple materials as available in every market in small towns in developing counties. 80 kg of raw bone and 6 kg of charcoal are used for production of 50 k...

  6. Report on Virginia Tech Shootings Urges Clarification of Privacy Laws

    Science.gov (United States)

    Fischer, Karin

    2007-01-01

    Educators, mental-health officials, and law-enforcement officers often do not share information about troubled students because they are confused by what they can disclose under complex and overlapping privacy laws, according to a report on the Virginia Tech shootings. Attorney General Alberto R. Gonzales and two other Bush cabinet secretaries…

  7. Another Innovation from High Tech High--Embedded Teacher Training

    Science.gov (United States)

    Griswold, Janie; Riordan, Rob

    2016-01-01

    High Tech High School's teaching internship program blends on-the-job work with classroom theory. Interns spend two years working as full teachers as they take courses. The program serves three large purposes: Train new teachers and build capacity in the HTH organization; train teachers in and beyond HTH for success in a wide range of contexts;…

  8. Biodegradation of oil spill by petroleum refineries using consortia of novel bacterial strains.

    Science.gov (United States)

    Singh, Bina; Bhattacharya, Amit; Channashettar, Veeranna A; Jeyaseelan, C Paul; Gupta, Sachin; Sarma, Priyangshu M; Mandal, Ajoy K; Lal, Banwari

    2012-08-01

    Feasibility study carried out at the site prior to the full scale study showed that the introduced bacterial consortium effectively adapted to the local environment of the soil at bioremediation site. The soil samples were collected from the contaminated fields after treatment with bacterial consortium at different time intervals and analyzed by gas chromatography after extraction with hexane and toluene. At time zero (just before initiation of bioremediation), the concentration of total petroleum hydrocarbons in the soil (25-cm horizon) of plot A, B, C and D was 30.90 %, 18.80 %, 25.90 % and 29.90 % respectively, after 360 days of treatment with microbial consortia was reduced to 0.97 %, 1.0 %, 1.0 %, and 1.1 % respectively. Whereas, only 5 % degradation was observed in the control plot after 365 days (microbial consortium not applied).

  9. Sustainable treatment potential of mixed algal consortia for domestic waste water: Growth and mixotrophy

    Directory of Open Access Journals (Sweden)

    Priyanka Murthy

    2015-04-01

    Full Text Available The increasing levels of generation of nutrient-rich waste water pose serious challenge. Conventional biological and chemical methods of waste water treatment have failed in meeting sustainability challenges. Naturally occurring mixed algal species reared in mixotrophic growth modes have been deployed to recover nutrients (N and P from domestic wastewater after anaerobic digestion. In this paper, we present the results pertaining to growth and mixotrophy. Pilot-scale operation shows that the cultivation methods adopted and the use of naturally selected species lead to a tendency among these species to clump at certain stages of growth that in turn float or settle rapidly making algal harvest and thereby the nutrient recovery processes energy efficient. The highest settling rate was found to be 6.37 ± 1.6 g/m2/d. Mixotrophy was seen to contribute 15 – 24 % across the various algal consortia in wastewater (polyculture.

  10. ZOOINDICATION AND PHYTOINDICATION OF AUTOTROPHIC AND HETEROTROPHIC CONSORTIA OF BIOGEOCOENOSES ORGANIZATION

    Directory of Open Access Journals (Sweden)

    Kunah O. N.

    2014-08-01

    Full Text Available The main results of ecomorfology structure of soil mesofauna in the adjacent area of Dneprovsko-Orylskiy Natural Reserve (Ireland Pogorily ore Dyka Kosa have been presented by the methods of OMI- and RLQ – analysis. The components of variability of the soil animal world (in colony of Ardea cinerea L., which is conditioned by auto- and heterotrophic consortia and also by influence of edaphically properties of biogeocoenoses were determined. Also we registered the high level and dynamics of mineral feed and presence of nitrogen in the soil. The results of description of taxonomic and ecological diversity in association of mesopedobionts were presented. We proved that the coenomorphic type of the animals was bog-forest. On the basic of joint measuring of edaphically descriptions and features of fauna structure we estimated the properties of ecological niche of soil mesofauna.

  11. Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

    Science.gov (United States)

    Everts, Maaike; Suto, Mark J; Painter, George R; Whitley, Richard J

    2016-03-01

    Viral infections, such as Ebola, severe acute respiratory syndrome/Middle East respiratory syndrome and West Nile virus have emerged as a serious health threat with no effective therapies. These infections have little commercial potential and are not a high priority for the pharmaceutical industry. However, the academic community has been active in this area for many years. The challenge is how to take this academic virology knowledge into a drug discovery and development domain. One approach is the use of consortia and public-private partnerships - this article highlights ongoing efforts in the USA. Public funds, such as those from government sources, can support research efforts that do not to appear to have commercial value. The key to success is finding a way to combine the different cultural and operational values and reward systems into a productive collaboration to identify new antivirals.

  12. The impact of industry/university consortia programs on space education

    Science.gov (United States)

    Page, John R.; Stone, Barbara A.

    1993-01-01

    The paper describes the industry/university consortia programs established by the United States and Australia and examines these programs from the viewpoint of their impact on space education in their respective countries. Particular attention is given to the aim and the nature of the three programs involved: the Centers for the Commercial Development of Space (CCDSs) (funded by NASA), which are currently involving about 250 companies and 88 universities as participants; the Space Industry Development Centers (SIDCs) (funded by the Australian Space Office): and the Cooperative Research Centers (CRCs) (funded by the Federal Government), which are not limited to the space area but are open to activities ranging from medical research to waste-water treatment. It is emphasized that, while the main aim of the CCDS, SIDC, and CRC programs is to develop space expertise, space education is a very significant byproduct of the activity of these agencies.

  13. Willingness to use pre-exposure prophylaxis (PrEP for HIV prevention among men who have sex with men (MSM in Malaysia: findings from a qualitative study

    Directory of Open Access Journals (Sweden)

    Adam Bourne

    2017-01-01

    Conclusions: This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those taking it may be stigmatized, it is crucial that the use of PrEP is presented as a responsible course of action, and one of a range of strategies that men can use to keep themselves safe from HIV.

  14. Anaerobic degradation of benzene by enriched consortia with humic acids as terminal electron acceptors

    Energy Technology Data Exchange (ETDEWEB)

    Cervantes, Francisco J., E-mail: fjcervantes@ipicyt.edu.mx [Division de Ciencias Ambientales, Instituto Potosino de Investigacion Cientifica y Tecnologica (IPICyT), Camino a la Presa San Jose 2055, Col. Lomas 4a. Seccion, San Luis Potosi, SLP, 78216 Mexico (Mexico); Mancilla, Ana Rosa; Toro, E. Emilia Rios-del [Division de Ciencias Ambientales, Instituto Potosino de Investigacion Cientifica y Tecnologica (IPICyT), Camino a la Presa San Jose 2055, Col. Lomas 4a. Seccion, San Luis Potosi, SLP, 78216 Mexico (Mexico); Alpuche-Solis, Angel G.; Montoya-Lorenzana, Lilia [Division de Biologia Molecular, Instituto Potosino de Investigacion Cientifica y Tecnologica (IPICyT), Camino a la Presa San Jose 2055, Col. Lomas 4a. Seccion, San Luis Potosi, SLP, 78216 Mexico (Mexico)

    2011-11-15

    Highlights: {yields} Enriched consortia were able to couple the anaerobic degradation of benzene to the reduction of humic acids. {yields} Electron-equivalents derived from anaerobic benzene oxidation were highly recovered as reduced humic acids. {yields} Several species from classes {beta}-, {delta}- and {gamma}-Proteobacteria were enriched during the anaerobic degradation of benzene. - Abstract: The anaerobic degradation of benzene coupled to the reduction of humic acids (HA) was demonstrated in two enriched consortia. Both inocula were able to oxidize benzene under strict anaerobic conditions when the humic model compound, anthraquinone-2,6-disulfonate (AQDS), was supplied as terminal electron acceptor. An enrichment culture originated from a contaminated soil was also able to oxidize benzene linked to the reduction of highly purified soil humic acids (HPSHA). In HPSHA-amended cultures, 9.3 {mu}M of benzene were degraded, which corresponds to 279 {+-} 27 micro-electron equivalents ({mu}Eq) L{sup -1}, linked to the reduction of 619 {+-} 81 {mu}Eq L{sup -1} of HPSHA. Neither anaerobic benzene oxidation nor reduction of HPSHA occurred in sterilized controls. Anaerobic benzene oxidation did not occur in soil incubations lacking HPSHA. Furthermore, negligible reduction of HPSHA occurred in the absence of benzene. The enrichment culture derived from this soil was dominated by two {gamma}-Proteobacteria phylotypes. A benzene-degrading AQDS-reducing enrichment originated from a sediment sample showed the prevalence of different species from classes {beta}-, {delta}- and {gamma}-Proteobacteria. The present study provides clear quantitative demonstration of anaerobic degradation of benzene coupled to the reduction of HA.

  15. Degradation products of 2,4,6-Trinitrotoluene by a microbial consortia

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, O.; Parker, C.; Bender, J. [Clark Atlanta Univ., Atlanta, GA (United States)] [and others

    1995-12-01

    Remediation of contaminated soils can be accomplished using microbial species. Of particular interest is the remediation of explosive contaminated soils. A microbial consortia has been developed which removes TNT by an unexplained mechanism. Our goal is to understand the degradation of TNT by this microbial mat. Constructed mats have been generated in our laboratory by enriching water with ensiled grass and adding specific microbial components for organic degradation. Microbial mats are natural mixed microbial communities dominated by cyanobacterias (blue-green algae). In this research, degradation products of TNT have been identified using GC/MS. Ninety-seven percent of TNT (1000 mg/L), was removed in < 1 day by floating mats placed over TNT-contaminated water in quiescent ponds. Metabolites of TNT, 2, 4-Dinitro-6 amminotoluene and 2-Nitro-4,6 diaminotoluene has been observed after 1 day of mat treatment. A mechanism is postulated for this degradation showing that two of the nitro groups of the TNT molecule are being reduced to amino groups systematically. Anoxic zones in the mat, containing sulfur-reducing bacteria, may account for the reduction of TNT. GC/MS shows significant decreases in metabolite concentrations in 4-7 days, indicating continued degradation of TNT. It has been found by toxicity assays that these metabolites appeared to be nontoxic and nonmutagenic. These results suggest that floating microbial mats may be useful for the decontamination of sites in the environment contaminated with TNT. Further studies using {sup 13}C TNT will focus on the fate of the carbon, to determine the intermediates products prior to transformations into hydrocarbons or utilization by the bacteria consortia.

  16. Detection of catabolic genes in indigenous microbial consortia isolated from a diesel-contaminated soil

    Energy Technology Data Exchange (ETDEWEB)

    Milcic-Terzic, J.; Saval, S. [National University of Mexico, Coyocan (Mexico). Institute of Engineering; Lopez-Vidal, Y. [National University of Mexico (Mexico). FAculty of Medicine; Vrvic, M.M. [University of Belgrade (Yugoslavia). Faculty of Chemistry

    2001-05-01

    Bioremediation is often used for in situ remediation of petroleum-contaminated sites. The primary focus of this study was on understanding the indigenous microbial community which can survive in contaminated environment and is responsible for the degradation. Diesel, toluene and naphthalene-degrading microbial consortia were isolated from diesel-contaminated soil by growing on selective hydrocarbon substrates. The presence and frequency of the catabolic genes responsible for aromatic hydrocarbon biodegradation (xylE, ndoB) within the isolated consortia were screened using polymerase chain reaction PCR and DNA-DNA colony hybridization. The diesel DNA-extract possessed both the xylE catabolic gene for toluene, and the nah catabolic gene for polynuclear aromatic hydrocarbon degradation. The toluene DNA-extract possessed only the xylE catabolic gene, while the naphthalene DNA-extract only the ndoB gene. Restriction enzyme analysis with HaeIII indicated similar restriction patterns for the xylE gene fragment between toluene DNA-extract and a type strain, Pseudomonas putida ATCC 23973. A substantial proportion (74%) of the colonies from the diesel-consortium possessed the xylE gene, and the ndoB gene (78%), while a minority (29%) of the toluene-consortium harbored the xylE gene. 59% of the colonies from the naphthalene-consortium had the ndoB gene, and did not have the xylE gene. These results indicate that the microbial population has been naturally enriched in organisms carrying genes for aromatic hydrocarbon degradation and that significant aromatic biodegradative potential exists at the site. Characterization of the population genotype constitutes a molecular diagnosis which permits the determination of the catabolic potential of the site to degrade the contaminant present. (author)

  17. 音乐院校图书馆联盟建设的思考%Reflections on the Construction of Music College Library Consortia

    Institute of Scientific and Technical Information of China (English)

    刘纪刚

    2012-01-01

    在阐述音乐院校图书馆联盟建设必要性的基础之上,应用SWOT进行分析,提出建设音乐院校图书馆联盟的措施,并提出建设音乐院校图书馆联盟应注意的问题。%This paper expounds the necessity of the construction of music college library consortia,and analyzes the construction of music college library consortia by SWOT.Furthermore,it brings forward the measures to construct music college library consortia and some matters to be pay attention to.

  18. TRAINING EMPLOYEES TO WORK WITH HI-TECH EQUIPMENT

    Directory of Open Access Journals (Sweden)

    M. A. Dremina

    2016-01-01

    Full Text Available The aim of the study is to describe a research relying on the capabilities of networking, which improves the quality of vocational training of skilled workers that are intended to work with new hi-tech equipment.Methods. Methods of system and comparative analysis, modeling, synthesis and generalization are used. Specification of the model of workers training offered by authors is carried out on the basis of deep interviews to experts – the representatives of the large enterprises who are carrying out training of the personnel.Results. Social and pedagogical contradictions are revealed, on the one hand, in the growing need for highly professional personnel for hi-tech productions, and, on the other hand, in insufficiently effective countermeasures of the system of vocational education and training on closing actual requirements of productions. The discrepancies reducing the quality of preparation of skilled workers are revealed by comparative analysis of competences based on an ideal competence model of the trainer and teacher of VET with the competences presented in educational both professional standards and the discussed projects. Characteristics of the existing pedagogical process in the hi-tech production environment are described. For the purpose of quality improvement of the pedagogical process, the network format of interactions of the enterprise, educational and the business organizations is offered.Scientific novelty. The concept «pedagogical process» for the purpose of making it more instrumental is specified; it joins a technological process and the design of its ideal model for the hi-tech production environment. The unique network project including design and development of innovative manuals and teaching materials for the welding equipment of Fronius International GmbH.Practical significance. The research results can be useful to the management of staff development and career advancement of hi-tech productions, and VET

  19. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    Directory of Open Access Journals (Sweden)

    Arcelino Farias-Neto

    2015-01-01

    Full Text Available Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  20. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers.

    Science.gov (United States)

    Farias-Neto, Arcelino; Gomes, Edna Maria da Cunha Ferreira; Sánchez-Ayala, Alfonso; Sánchez-Ayala, Alejandro; Vilanova, Larissa Soares Reis

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  1. Impact of gender and personality traits (BFI-10) on tech savviness

    DEFF Research Database (Denmark)

    Pavlicek, Antonin; Sudzina, Frantisek; Malinova, Ludmila

    2017-01-01

    Nowadays, it is necessary to use technology in various everyday activities. A certain level of what used to be called high-tech savviness is needed to access almost all modern services. The aim of this paper is to analyze if gender and personality traits (Big Five Inventory-10) influence self......-perceived tech savviness. A not so surprising finding is that gender influences self-perceived tech savviness, i.e. men consider themselves more tech savvy. Moreover, neuroticism has a negative and openness to experience has a positive impact on self-perceived tech savviness....

  2. Houston prefreshman enrichment program (Houston PREP). Final report, June 10, 1996--August 1, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The 1996 Houston Pre-freshman Enrichment Program (PREP) was conducted on the campus of the University of Houston-Downtown from June 10 to August 1, 1996. Program Participants were recruited from the Greater Houston area. All participants were identified as high achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Crockett, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 197 students starting the program, 170 completed, 142 students were from economically and socially disadvantage groups underrepresented in the engineering and science professions, and 121 of the 197 were female. Our First Year group for 1996 composed of 96% minority and women students. Our Second and Third Year students were 100% and 93.75% minority or women respectively. This gave an overall minority and female population of 93.75%. This year, special efforts were again made to recruit students from minority groups, which caused a significant increase in qualified applicants. However, due to space limitations, 140 applicants were rejected. Investigative and discovery learning were key elements of PREP. The academic components of the program included Algebraic Structures, Engineering, Introduction to Computer Science, Introduction to Physics, Logic and Its Application to Mathematics, Probability and Statistics, Problem Solving Seminar using computers and PLATO software, SAT Preparatory Seminars, and Technical Writing.

  3. Who should be offered HIV pre-exposure prophylaxis (PrEP)?: A secondary analysis of a Phase 3 PrEP efficacy trial in men who have sex with men and transgender women

    Science.gov (United States)

    Buchbinder, Susan P; Glidden, David V.; Liu, Albert Y.; McMahan, Vanessa; Guanira, Juan V.; Mayer, Kenneth H.; Goicochea, Pedro; Grant, Robert M.

    2014-01-01

    Background Pre-exposure prophylaxis (PrEP) has been proven to reduce HIV acquisition in men who have sex with men and transgender women (MSM/TGW). For maximal impact, PrEP should be targeted to subpopulations accounting for the largest proportion of infections (population attributable fraction, PAF) and for whom the number needed to treat (NNT) to prevent infection is lowest. Methods The iPrEx study was a randomized controlled efficacy trial of tenofovir-disoproxil-fumarate/emtricitabine PrEP in 2499 MSM/TGW on 4 continents. We calculated the association between demographic and risk behavior during screening with subsequent seroconversion among placebo recipients using a Poisson model, and the PAF and NNT for risk behavior subgroups. Findings Of 1248 placebo participants enrolled, 83 became HIV infected in follow-up. Participants reporting non-condom receptive anal intercourse (ncRAI) seroconverted significantly more often than MSM/TGW reporting no condomless anal sex (adjusted hazard ratio (AHR) 5·11, 95% CI 1·55-16·79). The overall PAF for MSM/TGW reporting ncRAI was 64% (prevalence=60%). Most of this risk came from ncRAI with unknown serostatus partners (PAF 53%, prevalence=54%, AHR 4·76); in contrast, the PAF for ncRAI with an HIV positive partner, an uncommon practice, was only 1% (prevalence 1%, AHR=7·11). The overall NNT per year for the cohort was 62 (95% CI 44-147). NNTs were lower for MSM/TGW self-reporting ncRAI, cocaine use, or a sexually transmitted infection (NNT= 36, 12, and 41 respectively). Having a single partner or non-condom insertive anal sex had the highest NNTs. Interpretation PrEP may be most effective at a population level if targeted toward MSM/TGW reporting ncRAI, even with partners perceived to be HIV negative. Substance use history and testing for STIs may also inform individual decisions to start PrEP. Considering PAF and NNT can aid in discussing the benefits and risks of PrEP with MSM/TGW. Funding Funded by the National

  4. GE Smart Prep半自动监控软件的应用要点%Application Keypoints of GE Light Speed 8 Smart Prep Semiautomatic Monitoring Software

    Institute of Scientific and Technical Information of China (English)

    肖建明

    2011-01-01

    目的 探讨GE light speed 8 smart Prep技术在CT血管造影中的准确应用.方法 采用GE light speed 8 Smart Pmp软件对35例患者进行颅脑CTA检查.结果 总结出GE light speed 8运用smart prep 的技术要点.%Objective To investigate the application of the GE light speed 8 smart prep technique in CT angiography. Methods Used GE light speed 8 Smart Prep software to assist the check of cerebral CTA in 35 patients. Results Summarized the application keypoints of CE light speed 8 smart prep technique.

  5. Prevalence and characteristics of users of pre-exposure prophylaxis (PrEP) among men who have sex with men, San Francisco, 2014 in a cross-sectional survey: implications for disparities.

    Science.gov (United States)

    Snowden, Jonathan M; Chen, Yea-Hung; McFarland, Willi; Raymond, Henry F

    2017-02-01

    Pre-exposure prophylaxis (PrEP) has gained a central role in prevention of HIV infection among men who have sex with men (MSM), particularly in San Francisco, California, USA. Programmes to enrol men in PrEP are being undertaken by a range of public and private organisations. PrEP will have the largest population impact if it reaches men who are most at risk for HIV infection, and is used in a manner that enables maximal efficacy. Access to PrEP also needs to be equitable. We report on the characteristics of men eligible for and using PrEP. Data were from the 2014 implementation of National HIV Behavioural Surveillance (NHBS) among MSM in San Francisco. NHBS uses venue-based sampling as the national standard for sampling MSM. We compare proportions of demographic characteristics of MSM using versus not using PrEP who are HIV-negative and meet Centers for Disease Control and Prevention guidelines to recommend PrEP. Overall, 64.1% of HIV-negative MSM in San Francisco would meet guidelines for PrEP use, while 9.2% of MSM overall and 14.5% of MSM eligible were using PrEP as of 2014. Men using PrEP are more likely to be white and of older age. There were no differences between men using and not using PrEP in terms of education, income and health insurance. PrEP roll-out efforts should attempt to increase reach for young, black and Hispanic MSM. Failure to equitably provide access to PrEP could exacerbate the US disparity in new HIV infections for men of colour. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. Pre-exposure Prophylaxis (PrEP) Use, Seroadaptation, and Sexual Behavior Among Men Who Have Sex with Men, San Francisco, 2004-2014.

    Science.gov (United States)

    Chen, Yea-Hung; Snowden, Jonathan M; McFarland, Willi; Raymond, H Fisher

    2016-12-01

    The Food and Drug Administration approved pre-exposure prophylaxis (PrEP) to prevent HIV infection, and the Centers for Disease Control and Prevention has presented PrEP as a prevention option for groups at high risk such as men who have sex with men (MSM). Intervention data provide some information on how PrEP affects sexual behavior of MSM in trials, open label extensions, or clinics. However, it is unclear whether sexual risk and preventive behavioral patterns are changing in the population as a whole as PrEP becomes more widely available, whether due to PrEP use or other factors. We examined trends in PrEP use, numbers of condomless anal sex partners, consistent condom use, and seroadaptive strategies in San Francisco-a city which has actively promoted PrEP-using data from National HIV Behavioral Surveillance (NHBS). NHBS recruited 1211, 383, 373, and 268 HIV-negative MSM in 2004, 2008, 2011, and 2014, respectively. PrEP use increased from zero in 2004, 2008, and 2011 to 9.6 % in 2014. The proportion of men with no condomless anal sex partners dropped from 60.6 % in 2004, to 58.2 % in 2008, to 54.2 % in 2011, to 40.2 % in 2014. Consistent condom use decreased from 36.8 % in 2004, and 30.5 % in 2008 and 2011, to 18.3 % in 2014. PrEP's introduction and scale-up enters in a pre-existing trend of decreasing condom use and increasing sexually transmitted infections among MSM which may be accelerating in recent years. While PrEP use should be scaled up as a prevention option among those who would benefit most, we believe that public health officials need to be realistic about the possibility that condom use could very well continue to decline as PrEP use increases, and to an extent that may not be directly or indirectly offset by PrEP.

  7. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    OpenAIRE

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R. (Rainer); Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D; Rouzioux, C

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  8. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    Science.gov (United States)

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R.; Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D.; Rouzioux, C.

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated. PMID:20129964

  9. Evaluation of an upgraded version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test for HIV-1 load quantification.

    Science.gov (United States)

    Damond, F; Avettand-Fenoel, V; Collin, G; Roquebert, B; Plantier, J C; Ganon, A; Sizmann, D; Babiel, R; Glaubitz, J; Chaix, M L; Brun-Vezinet, F; Descamps, D; Rouzioux, C

    2010-04-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  10. When are declines in condom use while using PrEP a concern? Modelling insights from a Hillbrow, South Africa case study

    Directory of Open Access Journals (Sweden)

    Hannah Grant

    2017-01-01

    Full Text Available Introduction: Oral pre-exposure prophylaxis (PrEP is a promising new prevention approach for those most at risk of HIV infection. However, there are concerns that behavioural disinhibition, specifically reductions in condom use, might limit PrEP’s protective effect. This study uses the case of female sex workers (FSWs in Johannesburg, South Africa, to assess whether decreased levels of condom use following the introduction of PrEP may limit HIV risk reduction.Methods: We developed a static model of HIV risk and compared HIV-risk estimates before and after the introduction of PrEP to determine the maximum tolerated reductions in condom use with regular partners and clients for HIV risk not to change. The model incorporated the effects of increased STI exposure owing to decreased condom use. Noting that condom use with regular partners is generally low, we also estimated the change in condom use tolerated with clients only, to still achieve 50 and 90% risk reduction on PrEP. The model was parameterized using data from Hillbrow, Johannesburg. Sensitivity analyses were performed to ascertain the robustness of our results.Results: Reductions in condom use could be tolerated by FSWs with lower baseline condom use (65%. For scenarios where 75% PrEP effectiveness is attained, 50% HIV-risk reduction on PrEP would be possible even with 100% reduction in condom use from consistent condom use as high as 70% with clients. Increased exposure to STIs through reductions in condom use had limited effect on the reductions in condom use tolerated for HIV risk not to increase on PrEP.Conclusions: PrEP is likely to be of benefit in reducing HIV risk, even if reductions in condom use do occur. Efforts to promote consistent condom use will be critical for FSWs with high initial levels of condom use, but with challenges in adhering to PrEP.

  11. Comparing the impact of increasing condom use or HIV pre-exposure prophylaxis (PrEP use among female sex workers

    Directory of Open Access Journals (Sweden)

    Zindoga Mukandavire

    2016-03-01

    Full Text Available In many settings, interventions targeting female sex workers (FSWs could significantly reduce the overall transmission of HIV. To understand the role HIV pre-exposure prophylaxis (PrEP could play in controlling HIV transmission amongst FSWs, it is important to understand how its impact compares with scaling-up condom use—one of the proven HIV prevention strategies for FSWs. It is important to remember that condoms also have other benefits such as reducing the incidence of sexually transmitted infections and preventing pregnancy. A dynamic deterministic model of HIV transmission amongst FSWs, their clients and other male partners (termed ‘pimps’ was used to compare the protection provided by PrEP for HIV-negative FSWs with FSWs increasing their condom use with clients and/or pimps. For different HIV prevalence scenarios, levels of pimp interaction, and baseline condom use, we estimated the coverage of PrEP that gives the same reduction in endemic FSW HIV prevalence or HIV infections averted as different increases in condom use. To achieve the same impact on FSW HIV prevalence as increasing condom use by 1%, the coverage of PrEP has to increase by >2%. The relative impact of PrEP increases for scenarios where pimps contribute to HIV transmission, but not greatly, and decreases with higher baseline condom use. In terms of HIV infections averted over 10 years, the relative impact of PrEP compared to condoms was reduced, with a >3% increase in PrEP coverage achieving the same impact as a 1% increase in condom use. Condom promotion interventions should remain the mainstay HIV prevention strategy for FSWs, with PrEP only being implemented once condom interventions have been maximised or to fill prevention gaps where condoms cannot be used.

  12. Essential Patents and Coordination Mechanisms : The effects of patent pools and industry consortia on the interplay between patents and technological standards

    OpenAIRE

    Baron, Justus; Pohlmann, Tim

    2010-01-01

    CERNA WORKING PAPER SERIES 2010-13; This article investigates the interplay between formal standards, essential patents and informal industry alliances such as consortia and patent pools. Building upon more than 6.200 declarations of essential patents to major international Standard Development Organizations (SDO), we investigate how informal standardization consortia and patent pools influence the number and timing of patent declarations to formal SDOs. This is the first thorough empirical i...

  13. Willingness to use short-term oral pre-exposure prophylaxis (PrEP) by migrant miners and female partners of migrant miners in Mozambique.

    Science.gov (United States)

    Falcao, Joana; Ahoua, Laurence; Zerbe, Allison; di Mattei, Pietro; Baggaley, Rachel; Chivurre, Victor; Mulondo, Prince; Ramiro, Isaias; Dalal, Shona; Morales, Fernando; O'Reilly, Kevin; El-Sadr, Wafaa

    2017-05-04

    Migrant miners from Mozambique who work in South Africa and their partners are at substantial risk for HIV infection. We conducted a cross-sectional study to assess the willingness of migrant miners and female partners of miners to take short-term pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition. The study was conducted in Gaza Province, Mozambique, between September and October 2015. A total of 131 male miners and female partners of male miners completed a questionnaire. Subsequently, 48 in-depth interviews among male miners and female partners of miners and 3 focus-group discussions (6 participants each) among female partners of miners were conducted. Quantitative data were tabulated using Stata. A structured coding scheme was developed and qualitative data were analysed using Atlas.ti. Most participants (94%) were willing to take PrEP for short-term use. Facilitating factors for willingness to use PrEP were concerns about partner's sexual behaviour, desire for pregnancy and one's own sexual behaviour. The main barriers to PrEP use were concerns regarding side-effects, perceived difficulty adhering to daily pill taking and concern about partner/family disapproval. Overall, participants saw potential barriers for PrEP as minor obstacles that could be overcome. The male partner's influence on PrEP use was significant.

  14. Effects of iron-reducing bacteria on carbon steel corrosion induced by thermophilic sulfate-reducing consortia.

    Science.gov (United States)

    Valencia-Cantero, Eduardo; Peña-Cabriales, Juan José

    2014-02-28

    Four thermophilic bacterial species, including the iron-reducing bacterium Geobacillus sp. G2 and the sulfate-reducing bacterium Desulfotomaculum sp. SRB-M, were employed to integrate a bacterial consortium. A second consortium was integrated with the same bacteria, except for Geobacillus sp. G2. Carbon steel coupons were subjected to batch cultures of both consortia. The corrosion induced by the complete consortium was 10 times higher than that induced by the second consortium, and the ferrous ion concentration was consistently higher in iron-reducing consortia. Scanning electronic microscopy analysis of the carbon steel surface showed mineral films colonized by bacteria. The complete consortium caused profuse fracturing of the mineral film, whereas the non-iron-reducing consortium did not generate fractures. These data show that the iron-reducing activity of Geobacillus sp. G2 promotes fracturing of mineral films, thereby increasing steel corrosion.

  15. IMPROVEMENT OF RESPONSE TO LOW WATER AVAILABILITY IN MAIZE PLANTS INOCULATED WITH SELECTED RHIZOSPHERIC MICROBIAL CONSORTIA UNDER DIFFERENT IRRIGATION REGIMES

    Directory of Open Access Journals (Sweden)

    Eligio Malusà

    2014-01-01

    Full Text Available Low water availability for agriculture is a rising problem in temperate countries. The effect of two different rhizospheric microbial consortia on the tolerance to water deficiency of maize was evaluated under controlled watering regimes. One consortium was a mixture of arbuscular mycorrhizal fungi and rhizospheric bacteria isolated under osmotic stress selective pressure; the other consortium was a commercial product. A higher tolerance of plants to water deficiency was observed when roots were inoculated with microbial consortia. Plant gas exchange parameters were positively affected by inoculation, and a improvements of the leaves mineral nutrients content and of the biomass yield were also recorded. The positive effect should be ascribed to an increased roots development more than to an increased uptake from extraradical mycorrhizal hyphae. The use of microbial inoculants appears to be a suitable practice to improve the crop performances under low water availability.

  16. Partial-prep bonded restorations in the anterior dentition: Long-term gingival health and predictability. A case report.

    Science.gov (United States)

    Molina, Ivan Contreras; Molina, Gil Contreras; Stanley, Kyle; Lago, Carlo; Xavier, Clessius Ferreira; Volpato, Claudia Angela Maziero

    2016-01-01

    Bonded porcelain restorations are a predictable and durable treatment option that can restore not only the strength and function of the teeth but also the esthetic appearance. One important issue in adhesive dentistry is the preservation of sound enamel. Following biomimetic principles, employing minimally invasive applications and adhesive technologies is of paramount importance for successful restorations. While it is widely accepted that minimally invasive restorative techniques should be favored, there is still some controversy over the noninvasive approaches. The purpose of this article is to question the complete "no-prep veneer" concept due to the possible negative effects on periodontal health caused by excessive contour and overhangs of the ceramic restoration, and to propose a new method to assess the quality and longevity of veneers with a partial-prep concept.

  17. Virginia Tech Wildlife Student Studies Cheetah Home Ranges

    OpenAIRE

    Davis, Lynn

    2003-01-01

    The cheetah may be the world's fastest land animal, accelerating to high speeds in just a few steps, but within recent years the cheetahs of South Africa are battling the race for survival. To find remedies for this problem Peter Laver, a graduate student in fisheries and wildlife sciences in the College of Natural Resources at Virginia Tech, is expanding current research on home ranges of the cheetah population located in the Serengeti National Park in Tanzania, Africa.

  18. Information literacy training in AgroParisTech food studies

    OpenAIRE

    Agnès Grimal; Florence Dubois-Brissonnet; Elisabeth Dumoulin

    2015-01-01

    AgroParisTech professors and librarians in Food Science and Technology have developed information literacy instruction to help students find and use relevant information. The course trains students to develop information literacy competencies: to identify the information needed and define its nature and extent; to access the information with efficiency because they select and use methods, resources and retrieval systems most appropriate to the topic; to evaluate the used methods, information,...

  19. Life Sciences at the University of Yachay Tech in Ecuador

    OpenAIRE

    Graciela Salum; Si Amar Dahoumane; Agathos, Spiros N.

    2016-01-01

    Yachay Tech University, home for more than 900 students and growing, has entered a new era and made a step forward in its development and fulfillment of the hopes placed on it. Indeed, its Schools have launched their careers offering the students a wide range of choices among programs of high academic level. The School of Biological Sciences and Engineering has started its two careers. The first one, coined "Biology," is designed for students aiming to gain knowledge either in "Organism...

  20. Virginia Tech Wildlife Student Studies Cheetah Home Ranges

    OpenAIRE

    Davis, Lynn

    2003-01-01

    The cheetah may be the world's fastest land animal, accelerating to high speeds in just a few steps, but within recent years the cheetahs of South Africa are battling the race for survival. To find remedies for this problem Peter Laver, a graduate student in fisheries and wildlife sciences in the College of Natural Resources at Virginia Tech, is expanding current research on home ranges of the cheetah population located in the Serengeti National Park in Tanzania, Africa.

  1. Orientace na konkurenci u hi-tech podniků

    Directory of Open Access Journals (Sweden)

    Lucie Kaňovská

    2013-10-01

    Full Text Available Purpose: The purpose of this paper is to examine the connection between market orientation and mainly competitor orientation and business performance at the hi-tech companies in the Czech Republic. Design/methodology/approach: The paper involves the New Method for measuring of market orientation. Data are collected through the survey and were used for the data analysis. Findings: The paper involves new aspects for perceiving competitor orientation, as a part of market orientation, and business performance. The result concurs with the results of researches of market orientation realized at this branch. Results show that competitor orientation has significant influence on business performance. Research limitations implications: The limitations are based on the methodology used for gaining data. However, the overall response rate is almost 20 %. The hi-tech industry is fast changing. From this reason, there can be many changes and it is impossible to repeat the research at the same companies. Practical implications: Our findings can help to understand market orientation and its relationship to competitors and business performance. Managers can use method for measuring of market orientation and can find out the level of market orientation at their companies. They can compare their results with the published average results of hi-tech companies. Originality/value: The originality of the paper comes from combining market orientation, the view of competition and business performance at hi-tech companies. The measurement of market orientation was made through the New Method. The model of the New method was constructed along after analysis of other 25 methods; we tried to eliminate the failings criticized in other methods.

  2. Virginia Tech to offer intensive English language refresher courses

    OpenAIRE

    2003-01-01

    Speaking and writing professionally with confidence are difficult for virtually everyone, but for those using a second language, these tasks pose a unique challenge. Virginia Tech's English Language Institute will address these needs by offering two intensive English language skills refresher classes during the semester break, from Jan. 5 to Jan. 16, 2004. Designed for graduate students, post-doctoral fellows, visiting scholars, and members of the international research community, this two-we...

  3. Entrepreneurship in high-tech and knowledge-intensive sectors

    DEFF Research Database (Denmark)

    Christensen, Patrizia V.; Madsen, Henning; Neergaard, Helle

    development of new enterprises in high-tech and knowledge-intensive sectors are analysed in relation to the educational and professional background of the entrepreneur/entrepreneurial team, as well as the personal and professional social networks of the entrepreneurs. The analysis is based on a theoretical...... framework combining theories of human and social capital. Secondary aspects addressed in the research project are questions of male vs. female entrepreneurship, internationalisation-globalisation, and business success/failure....

  4. Wearable high-tech gear for homeland security personnel

    Science.gov (United States)

    Venkateswarlu, Ronda; Hui Wei, Choo; Li Lian, Ngiam; Lim, E. T.; Zhu, Zijian; Yang, Mingjiang

    2006-05-01

    Recent homeland security problems in various countries indicate that fixed surveillance systems at important places are not adequate enough. As the security threats take new dimensions in future, mobile smart security personnel wearing high-tech gear will form the basic infrastructure. See first, listen first, detect first, track first, communicate first with peers, assess the threat and coordinate with security head-quarters are the functions of high-tech gear. This paper proposes a high-tech gear involving (i) hands-free and obtrusion-free textile-based wearable microphone array to capture users voice and interface with body-worn computer, (ii) microphone arrays embedded in textiles to listen and record others voices from a distance, (iii) miniature cameras embedded in the shirt to provide the user with omni vision (iv) wireless personal display as GUI hidden in textile or natural glasses, (v) GPS and body area network for positional awareness for information in the form of text or textile integrated, (vi) reconfigurable HW/SW for all the above functions configured in the form of a usual belt. The main focus of this paper is how to configure the high-tech gear with all these sophisticated functions to disappear into the natural wearables of the user giving him normal look in the public. This project is sponsored by Defence Science & Technology Agency, Ministry of Defence, Singapore. This paper covers multi-discipline technologies at system level, hence not possible to go into details of any subsystem. The main objective of this paper is to share our thoughts and get feedback. Progress and some critical design issues are discussed in this paper.

  5. Understanding Mexican High-tech Organizations: A Conceptualization Problem?

    OpenAIRE

    2001-01-01

    Working paper serie RMT (WPS 01-07), 23 p.; This study investigates the differences between intensive technology and low-tech firms located in Mexico, focusing on the Human Resources Management functions. 31 interviews and 50 answered questionnaires were used in this analysis. The results show that while Mexico is not yet a fully developed technological country. Indeed, technologically intensive firms are rare cases. Mexico is progressing rapidly towards a technologically developed country in...

  6. Phenotype fingerprinting suggests the involvement of single-genotype consortia in degradation of aromatic compounds by Rhodopseudomonas palustris.

    Directory of Open Access Journals (Sweden)

    Tatiana V Karpinets

    Full Text Available Anaerobic degradation of complex organic compounds by microorganisms is crucial for development of innovative biotechnologies for bioethanol production and for efficient degradation of environmental pollutants. In natural environments, the degradation is usually accomplished by syntrophic consortia comprised of different bacterial species. This strategy allows consortium organisms to reduce efforts required for maintenance of the redox homeostasis at each syntrophic level. Cellular mechanisms that maintain the redox homeostasis during the degradation of aromatic compounds by one organism are not fully understood. Here we present a hypothesis that the metabolically versatile phototrophic bacterium Rhodopseudomonas palustris forms its own syntrophic consortia, when it grows anaerobically on p-coumarate or benzoate as a sole carbon source. We have revealed the consortia from large-scale measurements of mRNA and protein expressions under p-coumarate, benzoate and succinate degrading conditions using a novel computational approach referred as phenotype fingerprinting. In this approach, marker genes for known R. palustris phenotypes are employed to determine the relative expression levels of genes and proteins in aromatics versus non-aromatics degrading condition. Subpopulations of the consortia are inferred from the expression of phenotypes and known metabolic modes of the R. palustris growth. We find that p-coumarate degrading conditions may lead to at least three R. palustris subpopulations utilizing p-coumarate, benzoate, and CO2 and H2. Benzoate degrading conditions may also produce at least three subpopulations utilizing benzoate, CO2 and H2, and N2 and formate. Communication among syntrophs and inter-syntrophic dynamics in each consortium are indicated by up-regulation of transporters and genes involved in the curli formation and chemotaxis. The N2-fixing subpopulation in the benzoate degrading consortium has preferential activation of the

  7. Phototrophic biofilm assembly in microbial-mat-derived unicyanobacterial consortia: model systems for the study of autotroph-heterotroph interactions

    Directory of Open Access Journals (Sweden)

    Jessica K Cole

    2014-04-01

    Full Text Available Microbial autotroph-heterotroph interactions influence biogeochemical cycles on a global scale, but the diversity and complexity of natural systems and their intractability to in situ manipulation make it challenging to elucidate the principles governing these interactions. The study of assembling phototrophic biofilm communities provides a robust means to identify such interactions and evaluate their contributions to the recruitment and maintenance of phylogenetic and functional diversity over time. To examine primary succession in phototrophic communities, we isolated two unicyanobacterial consortia from the microbial mat in Hot Lake, Washington, characterizing the membership and metabolic function of each consortium. We then analyzed the spatial structures and quantified the community compositions of their assembling biofilms. The consortia retained the same suite of heterotrophic species, identified as abundant members of the mat and assigned to Alphaproteobacteria, Gammaproteobacteria, and Bacteroidetes. Autotroph growth rates dominated early in assembly, yielding to increasing heterotroph growth rates late in succession. The two consortia exhibited similar assembly patterns, with increasing relative abundances of members from Bacteroidetes and Alphaproteobacteria concurrent with decreasing relative abundances of those from Gammaproteobacteria. Despite these similarities at higher taxonomic levels, the relative abundances of individual heterotrophic species were substantially different in the developing consortial biofilms. This suggests that, although similar niches are created by the cyanobacterial metabolisms, the resulting webs of autotroph-heterotroph and heterotroph-heterotroph interactions are specific to each primary producer. The relative simplicity and tractability of the Hot Lake unicyanobacterial consortia make them useful model systems for deciphering interspecies interactions and assembly principles relevant to natural

  8. Effect of rhizobacterial consortia from undisturbed arid- and agro-ecosystems on wheat growth under different conditions.

    Science.gov (United States)

    Inostroza, N G; Barra, P J; Wick, L Y; Mora, M L; Jorquera, M A

    2017-02-01

    Plant growth-promoting rhizobacteria (PGPR) are studied as complements/alternatives to chemical fertilizers used in agriculture. However, poor information exists on the potential of PGPR from undisturbed ecosystems. Here, we have evaluated the plant growth-promoting (PGP) effect of rhizobacterial consortia from undisturbed Chilean arid ecosystems (Consortium C1) and agro-ecosystems (Consortium C2) on plant biomass production. The PGP effects of C1 and C2 were assayed in wheat seedlings (Triticum aestivum L.) grown in pots under growth chamber conditions and in pots placed in an open greenhouse under natural conditions, using two different Chilean Andisols (Piedras Negras and Freire series) kept either at 30 or 60% of their maximum water holding capacity (MWHC). PGP effects depended on the soil type, MWHC and the growth conditions tested. Although both consortia showed PGB effects in artificial soils relative to controls in growth chambers, only C1 provoked a PGP effect at 60% MWHC in phosphorus-poor soil of the 'Piedras Negras' series. At natural conditions, however, only C1 exhibited statistically significant PGP effects at 30% MWHC in 'Piedras Negras', yet and most importantly allowed to maintain similar plant biomass as at 60% MWHC. Our results support possible applications of rhizobacterial consortia from arid ecosystems to improve wheat growth in Chilean Andisols under water shortage conditions. Wheat seedling inoculated with rhizobacterial consortia obtained from an undisturbed Chilean arid ecosystem showed improved growth in phosphorus-poor and partly dry soil. Arid ecosystems should be considered in further studies as an alternative source of microbial inoculants for agro-ecosystems subjected to stressful conditions by low nutrients and/or adverse climate events. © 2016 The Society for Applied Microbiology.

  9. Microbial biodiversity in cheese consortia and comparative Listeria growth on surfaces of uncooked pressed cheeses.

    Science.gov (United States)

    Callon, Cécile; Retureau, Emilie; Didienne, Robert; Montel, Marie-Christine

    2014-03-17

    The study set out to determine how changes in the microbial diversity of a complex antilisterial consortium from the surface of St-Nectaire cheese modify its antilisterial activities. On the basis of the microbial composition of a natural complex consortium named TR15 (Truefood consortium 15), three new consortia of different species and strain compositions were defined: TR15-SC (58 isolates from TR15 collection), TR15-M (pools of isolates from selective counting media) and TR15-BHI (pools of isolates from BHI medium). Their antilisterial activities on the surfaces of uncooked pressed cheese made with pasteurised milk were compared with the activity of complex consortium TR15 and a control cheese inoculated only with starter culture (Streptococcus thermophilus, Lactobacillus delbrueckii). The natural consortium TR15 was the most inhibitory, followed by reconstituted consortium TR15-BHI. The dynamics of the cheese rind microbial flora were monitored by counting on media and by isolate identification using 16S rDNA sequencing and direct 16S rDNA Single Strand Conformation Polymorphism analysis. The combination of these methods showed that rind with natural consortium TR15 had greater microbial diversity and different microbial dynamics than cheese rinds with reconstituted consortia. Cheese rind with the natural consortium showed higher citrate consumption and the highest concentrations of lactic and acetic acids, connected with high levels of lactic acid bacteria such as Carnobacterium maltaromaticum, Vagococcus fluvialis, Enterococcus gilvus, Leuconostoc mesenteroides, Brochothrix thermosphacta and Lactococcus lactis, ripening bacteria such as Arthrobacter nicotianae/arilaitensis, and Gram negative bacteria (Pseudomonas psychrophila and Enterobacter spp.). The highest L. monocytogenes count was on rind with TR15-M and was positively associated with the highest pH value, high succinic and citric acid contents, and the highest levels of Marinilactibacillus

  10. Information literacy training in AgroParisTech food studies

    Directory of Open Access Journals (Sweden)

    Agnès Grimal

    2015-10-01

    Full Text Available AgroParisTech professors and librarians in Food Science and Technology have developed information literacy instruction to help students find and use relevant information. The course trains students to develop information literacy competencies: to identify the information needed and define its nature and extent; to access the information with efficiency because they select and use methods, resources and retrieval systems most appropriate to the topic; to evaluate the used methods, information, and sources; to search, access and use information ethically and legally; to read, use and write bibliographic references.AgroParisTech trains two kinds of students. For Higher Education students (engineering students, the training takes place at their arrival in AgroParisTech, including courses and practical classes: role and management of information in organizations; information on plagiarism; resources in environment, food science and technology; use of relevant tools and methods for searching in databases; reference writing.For students attending a Master of Science, the training prepares them to produce a literature review. The curriculum includes: information about scientific integrity, plagiarism; information needed for a researcher; critical reading of a journal article; how to manage a literature review: resources used, information search with databases, full text access; reference writing.The students will use these information literacy skills along their studies as well as in their future jobs.

  11. Guide for the preparation of proposals for the Pre-Freshman Engineering Program: PREP-1981, (for minorities and women)

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The Pre-Freshman Engineering Program (PREP) for minorities and women (formerly PREFACE) will provide funds to colleges and universities for projects aimed at seeking out minority group individuals and women during junior high school and high school years (7th grade through the summer preceding matriculation in college) and providing them with enrichment experiences. Preparation and submission of proposals, evaluation and selection of proposals for support, and preparation of the final report are described.

  12. In-situ inhibition of Staphylococcus aureus by lactic acid bacteria consortia from two traditional Slovenian raw milk cheeses

    Directory of Open Access Journals (Sweden)

    Aljoša Trmčić

    2010-09-01

    Full Text Available Bacteriocin(s producing lactic acid bacteria naturally present in traditional cheeses represent an inexhaustive pool of microbes with safeguarding potential. Some bacteriocins produced by cheese lactic acid bacteria were already described as successful anti-staphylococcal agents. The presence of genes for bacteriocins with potential anti-staphylococcal activity was also demonstrated in two Slovenian traditional raw milk cheeses, “Tolminc” and “Kraški ovčji sir”. Same bacteriocin genes were also detected in viable lactic acid bacteria consortia’s isolated from “bacteriocin positive cheeses” on Rogosa, M17 and CATC agar media. The aim of the research was to elucidate whether or not this particular cheese consortia, in which bacteriocin genes were detected, actually exhibit anti-staphylococcal activity in milk and/or cheese. For this purpose different cheese consortia were selected in relation to versatility of detected bacteriocin genes and used to perform challenge tests against Staphylococcus aureus in milk and cheese. In milk following the time/temperature regime of traditional cheese production all cheese consortia effectively inhibited growth of Staphylococcus aureus in the range of app. 2 to 3 log. In cheese the inhibition of staphylococci was less pronounced but still evident since inhibition of app. 1.5 log was detected. Sole inhibition by lactic acid production was ruled out whilelinking inhibition directly to bacteriocin production would take some additional work.

  13. Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology

    DEFF Research Database (Denmark)

    Rozemeijer, Kirsten; Naber, Steffie K; Penning, Corine

    2017-01-01

    Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry...... of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 normal screening samples (23 833 123 person years).Exposure Use of SurePath or ThinPrep versus conventional cytology as screening test.Main outcome measure 72 month cumulative incidence...... was 58.5 (95% confidence interval 54.6 to 62.7) per 100 000 normal conventional cytology samples, compared with 66.8 (56.7 to 78.7) for ThinPrep and 44.6 (37.8 to 52.6) for SurePath. Compared with conventional cytology, the hazard of invasive cancer was 19% lower (hazard ratio 0.81, 95% confidence...

  14. Willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in Malaysia: findings from a qualitative study.

    Science.gov (United States)

    Bourne, Adam; Cassolato, Matteo; Thuan Wei, Clayton Koh; Wang, Bangyuan; Pang, Joselyn; Lim, Sin How; Azwa, Iskandar; Yee, Ilias; Mburu, Gitau

    2017-08-02

    Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake. As part of a larger mixed-methods study exploring acceptability and willingness to use PrEP among MSM in Malaysia, 19 men took part in audio-recorded focus group discussions hosted by a community-based HIV organization and facilitated by a trained researcher. Discussions focussed on awareness and potential information management, general perceptions of PrEP and potential motivations or barriers to the use of PrEP, including those at the personal, social, health system or structural level. Data were transcribed verbatim and underwent a detailed thematic analysis. Rather than perceiving PrEP as a replacement for condoms in terms of having safer sex, many participants viewed it as an additional layer protection, serving as a crucial barrier to infection on occasions where condom use was intended, but did not occur. It was also perceived as more valuable to "at-risk" men, such as those in HIV sero-discordant relationships or those with a higher number of sexual partners. Elements of discussion tended to suggest that some men taking PrEP may be subject to stigma from others, on the assumption they may be promiscuous or engage in high-risk sexual behaviours. This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those

  15. Microbial consortia in mesocosm bioremediation trial using oil sorbents, slow-release fertilizer and bioaugmentation.

    Science.gov (United States)

    Gertler, Christoph; Gerdts, Gunnar; Timmis, Kenneth N; Golyshin, Peter N

    2009-08-01

    An experimental prototype oil boom including oil sorbents, slow-release fertilizers and biomass of the marine oil-degrading bacterium, Alcanivorax borkumensis, was applied for sorption and degradation of heavy fuel oil in a 500-L mesocosm experiment. Fingerprinting of DNA and small subunit rRNA samples for microbial activity conducted to study the changes in microbial communities of both the water body and on the oil sorbent surface showed the prevalence of A. borkumensis on the surface of the oil sorbent. Growth of this obligate oil-degrading bacterium on immobilized oil coincided with a 30-fold increase in total respiration. A number of DNA and RNA signatures of aromatic hydrocarbon-degrading bacteria were detected both in samples of water body and on oil sorbent. Ultimately, the heavy fuel oil in this mesocosm study was effectively removed from the water body. This is the first study to successfully investigate the fate of oil-degrading microbial consortia in an experimental prototype for a bioremediation strategy in offshore, coastal or ship-bound oil spill mitigation using a combination of mechanical and biotechnological techniques.

  16. Consortia of microalgae and bacteria in the performance of a stabilization pond system treating landfill leachate.

    Science.gov (United States)

    Costa, R H R; Martins, C L; Fernandes, H; Velho, V F

    2014-01-01

    This study treated sanitary landfill leachate and was conducted in a pilot-scale system composed of three serial ponds (P1, P2 and P3), followed by a rock filter, in order to evaluate the microbial consortium influence on system performance and to investigate microorganism dynamics in the process. The system was broken into three stages, with a continuous flow rate (Q = 200 L d⁻¹) for 43 weeks. The stages were as follows: conventional operation (stage I), 12 h aeration in P2 (stage II), and 18 h aeration in P2 (stage III). The results showed the possibilities for treating landfill leachate, presenting an average efficiency of 75% for both filtered biochemical oxygen demand and ammonium. At the end of stage III, the ammonium concentration was 6 mg L⁻¹, which is lower than that established by Brazilian regulations for wastewater discharge (CONAMA 430/2011). The aeration applied in P2 led to a change in the microbial consortia during the second and third stage, which influenced the quality of the final effluent. The best performance was seen in stage III, where the system showed high microbial diversity, including the presence of nitrifying bacteria.

  17. Anaerobic BTEX degradation in soil bioaugmented with mixed consortia under nitrate reducing conditions

    Institute of Scientific and Technical Information of China (English)

    DOU Junfeng; LIU Xiang; HU Zhifeng

    2008-01-01

    Different concentrations of BTEX, including benzene, toluene, ethylbenzene, and three xylene isomers, were added into soil samples to investigate the anaerobic degradation potential by the augmented BTEX-adapted consortia under niwate reducing conditiom. All the BTEX substrates could be anaerobically biodegraded to non-detectable levels within 70 d when the initial concentrations were below 100 mg/kg in soil. Toluene was degraded faster than any other BTEX compounds, and the high-to-low order ofdegradation rates were toluene>ethylbenzene>m. xylene>o-xylene>benzene>P. xylene. Nitrite was accumulated with nitrate reduction. but the accumulation of nitrite had no inhibitory effect on the degradation of BTEX throughout the whole incubation. Indigenous bacteria in tIle soil could enhance the BTEX biodegradation ability of the enriched mixed bacteria. When the six BTEX compounds were simultaneously present in soil, there was no apparent inhibitory effect on their degradation with lower initial concentrations. Alternatively, benzene, o-xylene, and P-xylene degradation were inhibited with higher initial concentrations of 300 mg/kg. Higher BTEX biodegradation rates were observed in soil samples with the addition of sodium acetate compared to the presence of a single BTEX substrate. and the hypothesis of primary-substrate stimulation or cometabolic enhancement of BTEX biodegradation seems likely.

  18. Decolorization potential of mixed microbial consortia for reactive and disperse textile dyestuffs.

    Science.gov (United States)

    Asgher, Muhammad; Bhatti, H N; Shah, S A H; Asad, M Javaid; Legge, R L

    2007-06-01

    Four different aerobic mixed consortia collected from basins of wastewater streams coming out of dying plants of Crescent Textile (CT), Sitara Textile (ST), Chenab Fabrics (CF) and Noor Fatima Textile (NF), Faisalabad, Pakistan were applied for decolorization of Drimarene Orange K-GL, Drimarene Brilliant Red K-4BL, Foron Yellow SE4G and Foron Blue RDGLN for 10 days using the shake flask technique. CT culture showed the best decolorization potential on all dyestuffs followed by ST, NF and CF, respectively. CT could completely decolorize all dyes within 3-5 days. ST cultures showed effective decolorization potential on Foron Yellow SE4G and Drimarene Brilliant Red K-4BL but complete color removal was achieved after 4 and 7 days, respectively. NF culture showed 100% decolorization efficiencies on Foron Yellow SE4G and Foron Blue RDGLN but it took comparatively longer time periods (5-7 days). Where as, the NF culture had decolorized only 40% and 50% of Drimarene orange and red, respectively, after 10 days. CF caused complete decolorization of Foron Blue RDGLN and Drimarene Brilliant Red K-4BL after 4 and 8 days, respectively but it showed poor performance on other two dyes.

  19. Quantitative Molecular Assay for Fingerprinting Microbial Communities of Wastewater and Estrogen-Degrading Consortia

    Science.gov (United States)

    Yu, Chang-Ping; Ahuja, Rajiv; Sayler, Gary; Chu, Kung-Hui

    2005-01-01

    A quantitative fingerprinting method, called the real-time terminal restriction fragment length polymorphism (real-time-t-RFLP) assay, was developed for simultaneous determination of microbial diversity and abundance within a complex community. The real-time-t-RFLP assay was developed by incorporating the quantitative feature of real-time PCR and the fingerprinting feature of t-RFLP analysis. The assay was validated by using a model microbial community containing three pure strains, an Escherichia coli strain (gram negative), a Pseudomonas fluorescens strain (gram negative), and a Bacillus thuringiensis strain (gram positive). Subsequently, the real-time-t-RFLP assay was applied to and proven to be useful for environmental samples; the richness and abundance of species in microbial communities (expressed as the number of 16S rRNA gene copies of each ribotype per milliliter) of wastewater and estrogen-degrading consortia (enriched with 17α-estradiol, 17β-estradiol, or estrone) were successfully characterized. The results of this study strongly suggested that the real-time-t-RFLP assay can be a powerful molecular tool for gaining insight into microbial communities in various engineered systems and natural habitats. PMID:15746346

  20. Veterinary school consortia as a means of promoting the food-supply veterinary medicine pipeline.

    Science.gov (United States)

    Moore, Dale A

    2006-01-01

    Ideas about centers of emphasis and veterinary medical teaching consortia have resurfaced to attract students into food-supply veterinary medicine (FSVM). From 1988 to 2000 a multiple veterinary school consortium approach to food-animal production medicine (FAPM) teaching was conducted to handle regional differences in case load, faculty strengths, and student interests. Six universities developed a memorandum of understanding to provide a wide variety of in-depth, species-specific clinical experiences in FAPM to balance their individual strengths and weakness in addressing food-animal agriculture, to provide for student exchange and faculty development, and to conduct research in food safety. Changes in leadership, redirection of funds, failure to publicize the program to faculty and students, and a focus on research as opposed to teaching led to dissolution of the consortium. However, this approach could work to improve recruitment and retention of students in FSVM if it focused on student exchange, fostered a more integrated curriculum across schools, encouraged faculty involvement, garnered institutional support, and used modern technology in teaching. Private veterinary practices as well as public/corporate practices could be integrated into a broader food-animal curriculum directed at building competency among FSVM students by providing the in-depth training they require. Requirements for the success of this type of program will include funding, marketing, leadership, communication, coordination, integration, and dedicated people with the time to make it work.

  1. Characterization of corrosive bacterial consortia isolated from petroleum-product-transporting pipelines.

    Science.gov (United States)

    Rajasekar, Aruliah; Anandkumar, Balakrishnan; Maruthamuthu, Sundaram; Ting, Yen-Peng; Rahman, Pattanathu K S M

    2010-01-01

    Microbiologically influenced corrosion is a problem commonly encountered in facilities in the oil and gas industries. The present study describes bacterial enumeration and identification in diesel and naphtha pipelines located in the northwest and southwest region in India, using traditional cultivation technique and 16S rDNA gene sequencing. Phylogenetic analysis of 16S rRNA sequences of the isolates was carried out, and the samples obtained from the diesel and naphtha-transporting pipelines showed the occurrence of 11 bacterial species namely Serratia marcescens ACE2, Bacillus subtilis AR12, Bacillus cereus ACE4, Pseudomonas aeruginosa AI1, Klebsiella oxytoca ACP, Pseudomonas stutzeri AP2, Bacillus litoralis AN1, Bacillus sp., Bacillus pumilus AR2, Bacillus carboniphilus AR3, and Bacillus megaterium AR4. Sulfate-reducing bacteria were not detected in samples from both pipelines. The dominant bacterial species identified in the petroleum pipeline samples were B. cereus and S. marcescens in the diesel and naphtha pipelines, respectively. Therefore, several types of bacteria may be involved in biocorrosion arising from natural biofilms that develop in industrial facilities. In addition, localized (pitting) corrosion of the pipeline steel in the presence of the consortia was observed by scanning electron microscopy analysis. The potential role of each species in biofilm formation and steel corrosion is discussed.

  2. Nanobarium Titanate As Supplement To Accelerate Plastic Waste Biodegradation By Indigenous Bacterial Consortia

    Science.gov (United States)

    Kapri, Anil; Zaidi, M. G. H.; Goel, Reeta

    2009-06-01

    Plastic waste biodegradation studies have seen several developmental phases from the discovery of potential microbial cultures, inclusion of photo-oxidizable additives into the polymer chain, to the creation of starch-embedded biodegradable plastics. The present study deals with the supplementation of nanobarium titanate (NBT) in the minimal broth in order to alter the growth-profiles of the Low-density polyethylene (LDPE) degrading consortia. The pro-bacterial influence of the nanoparticles could be seen by substantial changes such as shortening of the lag phase and elongation of the exponential as well as stationary growth phases, respectively, which eventually increase the biodegradation efficiency. In-vitro biodegradation studies revealed better dissolution of LDPE in the presence of NBT as compared to control. Significant shifting in λ-max values was observed in the treated samples through UV-Vis spectroscopy, while Fourier transform infrared spectroscopy (FTIR) and simultaneous thermogravimetric-differential thermogravimetry-differential thermal analysis (TG-DTG-DTA) further confirmed the breakage and formation of bonds in the polymer backbone. Therefore, this study suggests the implementation of NBT as nutritional additive for plastic waste management through bacterial growth acceleration.

  3. Study of phenanthrene utilizing bacterial consortia associated with cowpea (Vigna unguiculata) root nodules.

    Science.gov (United States)

    Sun, Ran; Crowley, David E; Wei, Gehong

    2015-02-01

    Many legumes have been selected as model plants to degrade organic contaminants with their special associated rhizosphere microbes in soil. However, the function of root nodules during microbe-assisted phytoremediation is not clear. A pot study was conducted to examine phenanthrene (PHE) utilizing bacteria associated with root nodules and the effects of cowpea root nodules on phytoremediation in two different types of soils (freshly contaminated soil and aged contaminated soil). Cowpea nodules in freshly-contaminated soil showed less damage in comparison to the aged-contaminated soil, both morphologically and ultra-structurally by scanning electron microscopy. The study of polycyclic aromatic hydrocarbon (PAH) attenuation conducted by high performance liquid chromatography revealed that more PAH was eliminated from liquid culture around nodulated roots than nodule-free roots. PAH sublimation and denaturation gradient gel electrophoresis were applied to analyze the capability and diversity of PAH degrading bacteria from the following four parts of rhizo-microzone: bulk soil, root surface, nodule surface and nodule inside. The results indicated that the surface and inside of cowpea root nodules were colonized with bacterial consortia that utilized PHE. Our results demonstrated that root nodules not only fixed nitrogen, but also enriched PAH-utilizing microorganisms both inside and outside of the nodules. Legume nodules may have biotechnological values for PAH degradation.

  4. Trichloroethylene aerobic cometabolism by suspended and immobilized butane-growing microbial consortia: a kinetic study.

    Science.gov (United States)

    Frascari, Dario; Zanaroli, Giulio; Bucchi, Giacomo; Rosato, Antonella; Tavanaie, Nasrin; Fraraccio, Serena; Pinelli, Davide; Fava, Fabio

    2013-09-01

    A kinetic study of butane uptake and trichloroethylene (TCE) aerobic cometabolism was conducted by two suspended-cell (15 and 30°C) and two attached-cell (15 and 30°C) consortia obtained from the indigenous biomass of a TCE-contaminated aquifer. The shift from suspended to attached cells resulted in an increase of butane (15 and 30°C) and TCE (15°C) biodegradation rates, and a significant decrease of butane inhibition on TCE biodegradation. The TCE 15°C maximum specific biodegradation rate was equal to 0.011 mg(TCE ) mg(protein)(-1) d(-1) with suspended cells and 0.021 mg(TCE) mg(protein)(-1) d(-1) with attached cells. The type of mutual butane/TCE inhibition depended on temperature and biomass conditions. On the basis of a continuous-flow simulation, a packed-bed PFR inoculated with the 15 or 30°C attached-cell consortium could attain a 99.96% conversion of the studied site's average TCE concentration with a 0.4-0.5-day hydraulic residence time, with a low effect of temperature on the TCE degradation performances.

  5. Genomic mining for novel FADH₂-dependent halogenases in marine sponge-associated microbial consortia.

    Science.gov (United States)

    Bayer, Kristina; Scheuermayer, Matthias; Fieseler, Lars; Hentschel, Ute

    2013-02-01

    Many marine sponges (Porifera) are known to contain large amounts of phylogenetically diverse microorganisms. Sponges are also known for their large arsenal of natural products, many of which are halogenated. In this study, 36 different FADH₂-dependent halogenase gene fragments were amplified from various Caribbean and Mediterranean sponges using newly designed degenerate PCR primers. Four unique halogenase-positive fosmid clones, all containing the highly conserved amino acid motif "GxGxxG", were identified in the microbial metagenome of Aplysina aerophoba. Sequence analysis of one halogenase-bearing fosmid revealed notably two open reading frames with high homologies to efflux and multidrug resistance proteins. Single cell genomic analysis allowed for a taxonomic assignment of the halogenase genes to specific symbiotic lineages. Specifically, the halogenase cluster S1 is predicted to be produced by a deltaproteobacterial symbiont and halogenase cluster S2 by a poribacterial sponge symbiont. An additional halogenase gene is possibly produced by an actinobacterial symbiont of marine sponges. The identification of three novel, phylogenetically, and possibly also functionally distinct halogenase gene clusters indicates that the microbial consortia of sponges are a valuable resource for novel enzymes involved in halogenation reactions.

  6. Characterization of corrosive bacterial consortia isolated from petroleum-product-transporting pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Rajasekar, Aruliah; Ting, Yen-Peng [National Univ. of Singapore (Singapore). Dept. of Chemical and Biomolecular Engineering; Anandkumar, Balakrishnan [Sourashtra Coll., Madurai (India). Dept. of Biotechnology; Maruthamuthu, Sundaram [Central Electrochemical Research Inst., Karaikudi (India). Biocorrosion Group; Rahman, Pattanathu K.S.M. [Teesside Univ., Tees Valley (United Kingdom). Chemical and Bioprocess Engineering Group

    2010-01-15

    Microbiologically influenced corrosion is a problem commonly encountered in facilities in the oil and gas industries. The present study describes bacterial enumeration and identification in diesel and naphtha pipelines located in the northwest and southwest region in India, using traditional cultivation technique and 16S rDNA gene sequencing. Phylogenetic analysis of 16S rRNA sequences of the isolates was carried out, and the samples obtained from the diesel and naphtha-transporting pipelines showed the occurrence of 11 bacterial species namely Serratia marcescens ACE2, Bacillus subtilis AR12, Bacillus cereus ACE4, Pseudomonas aeruginosa AI1, Klebsiella oxytoca ACP, Pseudomonas stutzeri AP2, Bacillus litoralis AN1, Bacillus sp., Bacillus pumilus AR2, Bacillus carboniphilus AR3, and Bacillus megaterium AR4. Sulfate-reducing bacteria were not detected in samples from both pipelines. The dominant bacterial species identified in the petroleum pipeline samples were B. cereus and S. marcescens in the diesel and naphtha pipelines, respectively. Therefore, several types of bacteria may be involved in biocorrosion arising from natural biofilms that develop in industrial facilities. In addition, localized (pitting) corrosion of the pipeline steel in the presence of the consortia was observed by scanning electron microscopy analysis. The potential role of each species in biofilm formation and steel corrosion is discussed. (orig.)

  7. 'Pop-Up' Governance: developing internal governance frameworks for consortia: the example of UK10K.

    Science.gov (United States)

    Kaye, Jane; Muddyman, Dawn; Smee, Carol; Kennedy, Karen; Bell, Jessica

    2015-01-01

    Innovations in information technologies have facilitated the development of new styles of research networks and forms of governance. This is evident in genomics where increasingly, research is carried out by large, interdisciplinary consortia focussing on a specific research endeavour. The UK10K project is an example of a human genomics consortium funded to provide insights into the genomics of rare conditions, and establish a community resource from generated sequence data. To achieve its objectives according to the agreed timetable, the UK10K project established an internal governance system to expedite the research and to deal with the complex issues that arose. The project's governance structure exemplifies a new form of network governance called 'pop-up' governance. 'Pop-up' because: it was put together quickly, existed for a specific period, was designed for a specific purpose, and was dismantled easily on project completion. In this paper, we use UK10K to describe how 'pop-up' governance works on the ground and how relational, hierarchical and contractual governance mechanisms are used in this new form of network governance.

  8. Characterization of two diesel fuel degrading microbial consortia enriched from a non acclimated, complex source of microorganisms

    Directory of Open Access Journals (Sweden)

    Varese Giovanna C

    2010-02-01

    Full Text Available Abstract Background The bioremediation of soils impacted by diesel fuels is very often limited by the lack of indigenous microflora with the required broad substrate specificity. In such cases, the soil inoculation with cultures with the desired catabolic capabilities (bioaugmentation is an essential option. The use of consortia of microorganisms obtained from rich sources of microbes (e.g., sludges, composts, manure via enrichment (i.e., serial growth transfers on the polluting hydrocarbons would provide bioremediation enhancements more robust and reproducible than those achieved with specialized pure cultures or tailored combinations (co-cultures of them, together with none or minor risks of soil loading with unrelated or pathogenic allocthonous microorganisms. Results In this work, two microbial consortia, i.e., ENZ-G1 and ENZ-G2, were enriched from ENZYVEBA (a complex commercial source of microorganisms on Diesel (G1 and HiQ Diesel (G2, respectively, and characterized in terms of microbial composition and hydrocarbon biodegradation capability and specificity. ENZ-G1 and ENZ-G2 exhibited a comparable and remarkable biodegradation capability and specificity towards n-C10 to n-C24 linear paraffins by removing about 90% of 1 g l-1 of diesel fuel applied after 10 days of aerobic shaken flask batch culture incubation at 30°C. Cultivation dependent and independent approaches evidenced that both consortia consist of bacteria belonging to the genera Chryseobacterium, Acinetobacter, Psudomonas, Stenotrophomonas, Alcaligenes and Gordonia along with the fungus Trametes gibbosa. However, only the fungus was found to grow and remarkably biodegrade G1 and G2 hydrocarbons under the same conditions. The biodegradation activity and specificity and the microbial composition of ENZ-G1 and ENZ-G2 did not significantly change after cryopreservation and storage at -20°C for several months. Conclusions ENZ-G1 and ENZ-G2 are very similar highly enriched consortia

  9. Quantitative Detection of Screening for Cervical Lesions with ThinPrep Cytology Test

    Institute of Scientific and Technical Information of China (English)

    Hong-xin ZHANG; Yi-min SONG; Su-hong LI; Yu-hui YIN; Dong-ling GAO; Kui-sheng CHEN

    2010-01-01

    OBJECTIVE To investigate the available parameters in gynecological screening for cervical lesions by liquid-based cytology technology (ThinPrep Cytology Test, TCT) and The Bethesda System (TBS), also with computer image analysis. METHODS With application of the image analysis system, all grades of cervical lesion cells were detected quantitatively and sorted in atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells-cannot exclude HSIL (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma (SCC) with the mean optical density (MOD), average grey (AG), positive units (PU), and nucleus to cytoplasmic ratio (N:C). Differences between each group of cells were compared and analyzed statistically.RESULTS Apart from four stereologic parameters in LSIL and HSIL groups there were no differences among them, in the other groups, there was statistically significant in differences between MOD, AG and PU values. Differences between them in the ratio of nucleus to cytoplasm were highly statistically signifi cant. CONCLUSION Stereological indexes may serve as a screening tool for cervical lesions. The image analysis system is expected to become a new means of cytological assisted diagnosis.

  10. Morphologic features of prostatic adenocarcinoma on ThinPrep® urinary cytology.

    Science.gov (United States)

    Tyler, Kevin L; Selvaggi, Suzanne M

    2011-02-01

    Malignant cells of prostatic adenocarcinoma are rarely identified in urine. In most cases, this finding is associated with high stage tumor. Numerous descriptions of the morphology of prostatic adenocarcinoma have been reported using cytocentrifugated specimens. However, no specific morphologic description of prostatic adenocarcinoma in urine using liquid-based cytology has been previously described. Four cases of prostatic adenocarcinoma in urine using ThinPrep® liquid-based preparations were identified between 2002 and 2009 at the University of Wisconsin Hospital and Clinics. Three patients had either high stage tumor or metastatic disease at the time of diagnosis, while the remaining patient had low stage tumor. The morphology of each case was evaluated with specific attention to cell size, nuclear characteristics, nuclear to cytoplasmic ratio, and cytoplasmic characteristics. The resulting key features for prostatic adenocarcinoma in urine are clustering, increased nuclear to cytoplasmic ratio, and prominent nucleoli. Though typically the presence of prostatic adenocarcinoma in urine implies high stage tumor, cells of lower stage tumors may be seen in urine as well.

  11. Design and Realization of Information System for Ningxia Sci-tech Special Commissioners

    Institute of Scientific and Technical Information of China (English)

    Changhong; WANG

    2013-01-01

    The information system for Ningxia sci-tech special commissioners is an application system for realizing information collection,management and sharing in the entrepreneurial process of sci-tech special commissioners. This paper introduces overall design ideas,system functions,key technologies and realization methods of the information system for Ningxia sci-tech special commissioners. Completion of construction and coming into operation of the information system bring new breakthrough for information management and data statistics of sci-tech special commissioners.

  12. Hi-Tech and Fong’s show up on the ITMA

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The once every four years ITMA exhibition was held recently in Barcelona, Spain.China Hi-Tech Group Corporation attaches great importance on the exhibition as it is a grand event of textile industry. The total exhibition area for Hi-Tech Group and its branch companies is 1100 square meters including 11 equipments of cotton spinning, dyeing and finishing, nonwoven, which represents part of the latest research results of Hi-Tech Group. Moreover other machinery products of Hi-Tech Group are demonstrated on the exhibition through video, pictures and brochure.

  13. Low Tech Hacking Street Smarts for Security Professionals

    CERN Document Server

    Wiles, Jack; Jabbusch, Jennifer; Rogers, Russ; Lowther, Sean

    2011-01-01

    Criminals using hacking techniques can cost corporations, governments, and individuals millions of dollars each year. While the media focuses on the grand-scale attacks that have been planned for months and executed by teams and countries, there are thousands more that aren't broadcast. Low Tech Hacking focuses on the everyday hacks that, while simple in nature, actually add up to the most significant losses. Attackers are using common techniques like social engineering, wireless hacking, and targeting and surveillance to gain access to valuable data. This book contains detailed descriptions

  14. Black Hole - Neutron Star Binary Simulations at Georgia Tech

    Science.gov (United States)

    Haas, Roland

    2009-05-01

    Mixed compact object binaries consisting of a black hole and a neutron star are expected to be not only one of the primary sources of gravitational radiation to be observed by interferometric detectors but also the central engine of short gamma-ray bursts. We report on the status of our effort at Georgia Tech to model these mixed binary systems using the moving puncture method. The results are obtained with an enhanced version our vacuum MayaKranc code coupled to the hydrodynamics Whisky code. We present preliminary results of gravitational waveforms and the disruption of the neutron star for simple polytropic equations of state.

  15. Come and see our new high-tech products!

    CERN Multimedia

    GS Department

    2010-01-01

    Since 1977, GMP has been active in the fields of laser, spectroscopy, electro-optics and micropositioning. Its mission is to link between suppliers of high tech products with the end users. On Wednesday 26 May between 10 and 12 a.m. - Room A, Main Building, (Bldg. 61/1-017) - you will be able to touch and try out our new laser products. Our specialized engineers will also be on hand to answer all your questions. A drink will be offered at the end of the presentation. There will also be the opportunity to plan meetings in the afternoon to further discuss and complicated questions.

  16. Development of a data capture tool for researching tech entrepreneurship

    DEFF Research Database (Denmark)

    Andersen, Jakob Axel Bejbro; Howard, Thomas J.; McAloone, Tim C.

    2014-01-01

    Startups play a crucial role in exploiting the commercial advantages created by new, advanced technologies. Surprisingly, the processes by which the entrepreneur commercialises these technologies are largely undescribed - partly due to the absence of appropriate process data capture tools....... This paper elucidates the requirements for such tools by drawing on knowledge of the entrepreneurial phenomenon and by building on the existing research tools used in design research. On this basis, the development of a capture method for tech startup processes is described and its potential discussed....

  17. Hi-Tech Skills Anticipation for Sustainable Development in Russia

    Directory of Open Access Journals (Sweden)

    Valery Gurtov

    2014-12-01

    Full Text Available It is evident that there is a heightened importance in Russia attributed to ensuring that students develop skills, which will enable them to be more productive and engaged citizens. This article deals with a skills anticipation methodology for seven hi-tech industries in Russia that resulted in the development of models for both soft and hard skills. There is a variety of widely applied methods – qualitative projection of labor market parameters, desk studies, documents analysis, foresight sessions, employers' and experts' surveys. As a result, new skills models are to help the specialists to effectively overcome the challenges, apply innovative decisions, and increase their technological knowledge.

  18. Pudong:Building a Hi-tech Platform

    Institute of Scientific and Technical Information of China (English)

    LiJialin; WuXinyi

    2003-01-01

    The approach of the knowledge economy means that Shanghai-China's most international city-is advancing towards world metropolis status.As the Chinese saying goes, “In the north is Zhongguancun,and in the south is Zhangjiangyuan.”In order to promote their respective economic growth,both Beijing and Shanghai focus on high technologies.Their importance,as represented by the Zhangjiang Hi-tech Park,is daily becoming more prominent in Pudong,and consequently,the whole of Shanghai.

  19. The herbaceous landlord: integrating the effects of symbiont consortia within a single host.

    Science.gov (United States)

    Vandegrift, Roo; Roy, Bitty A; Pfeifer-Meister, Laurel; Johnson, Bart R; Bridgham, Scott D

    2015-01-01

    Plants are typically infected by a consortium of internal fungal associates, including endophytes in their leaves, as well as arbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) in their roots. It is logical that these organisms will interact with each other and the abiotic environment in addition to their host, but there has been little work to date examining the interactions of multiple symbionts within single plant hosts, or how the relationships among symbionts and their host change across environmental conditions. We examined the grass Agrostis capillaris in the context of a climate manipulation experiment in prairies in the Pacific Northwest, USA. Each plant was tested for presence of foliar endophytes in the genus Epichloë, and we measured percent root length colonized (PRLC) by AMF and DSE. We hypothesized that the symbionts in our system would be in competition for host resources, that the outcome of that competition could be driven by the benefit to the host, and that the host plants would be able to allocate carbon to the symbionts in such a way as to maximize fitness benefit within a particular environmental context. We found a correlation between DSE and AMF PRLC across climatic conditions; we also found a fitness cost to increasing DSE colonization, which was negated by presence of Epichloë endophytes. These results suggest that selective pressure on the host is likely to favor host/symbiont relationships that structure the community of symbionts in the most beneficial way possible for the host, not necessarily favoring the individual symbiont that is most beneficial to the host in isolation. These results highlight the need for a more integrative, systems approach to the study of host/symbiont consortia.

  20. Utilizing data consortia to monitor safety and effectiveness of biosimilars and their innovator products.

    Science.gov (United States)

    Baldziki, Mike; Brown, Jeff; Chan, Hungching; Cheetham, T Craig; Conn, Thomas; Daniel, Gregory W; Hendrickson, Mark; Hilbrich, Lutz; Johnson, Ayanna; Miller, Steven B; Moore, Tom; Motheral, Brenda; Priddy, Sarah A; Raebel, Marsha A; Randhawa, Gurvaneet; Surratt, Penny; Walraven, Cheryl; White, T Jeff; Bruns, Kevin; Carden, Mary Jo; Dragovich, Charlie; Eichelberger, Bernadette; Rosato, Edith; Sega, Todd

    2015-01-01

    The Biologics Price Competition and Innovation Act, introduced as part of the Affordable Care Act, directed the FDA to create an approval pathway for biologic products shown to be biosimilar or interchangeable with an FDA-approved innovator drug. These biosimilars will not be chemically identical to the reference agent. Investigational studies conducted with biosimilar agents will likely provide limited real-world evidence of their effectiveness and safety. How do we best monitor effectiveness and safety of biosimilar products once approved by the FDA and used more extensively by patients? To determine the feasibility of developing a distributed research network that will use health insurance plan and health delivery system data to detect biosimilar safety and effectiveness signals early and be able to answer important managed care pharmacy questions from both the government and managed care organizations. Twenty-one members of the AMCP Task Force on Biosimilar Collective Intelligence Systems met November 12, 2013, to discuss issues involved in designing this consortium and to explore next steps. The task force concluded that a managed care biosimilars research consortium would be of significant value. Task force members agreed that it is best to use a distributed research network structurally similar to existing DARTNet, HMO Research Network, and Mini-Sentinel consortia. However, for some surveillance projects that it undertakes, the task force recognizes it may need supplemental data from managed care and other sources (i.e., a "hybrid" structure model). The task force believes that AMCP is well positioned to lead the biosimilar-monitoring effort and that the next step to developing a biosimilar-innovator collective intelligence system is to convene an advisory council to address organizational governance.

  1. Influence of nutrients on oxidation of low level methane by mixed methanotrophic consortia.

    Science.gov (United States)

    Karthikeyan, Obulisamy Parthiba; Chidambarampadmavathy, Karthigeyan; Nadarajan, Saravanan; Heimann, Kirsten

    2016-03-01

    Low-level methane emissions from coal mine ventilation air (CMV-CH4; i.e., 1 % CH4) can significantly contribute to global climate change, and therefore, treatment is important to reduce impacts. To investigate CMV-CH4 abatement potential, five different mixed methanotrohic consortia (MMCs) were established from soil/sediment sources, i.e., landfill top cover soil, bio-solid compost, vegetated humus soil, estuarine and marine sediments. Enrichment conditions for MMCs were as follows: nitrate mineral salt (NMS) medium, pH ~ 6.8; 25 °C; 20-25 % CH4; agitation 200 rpm; and culture period 20 days, in mini-bench-top bioreactors. The enriched cultures were supplemented with extra carbon (methanol 0.5-1.5 %, formate 5-15 mM, and acetate 5-15 mM), nitrogen (nitrate 0.5-1.5 g L(-1), ammonium 0.1-0.5 g L(-1), or urea: 0.1-0.5 g L(-1)), and trace elements (copper 1-5 μM, iron 1-5 μM, and zinc 1-5 μM) in different batch experiments to improve low-level CH4 abatement. Average CH4 oxidation capacities (MOCs) of MMCs varied between 1.712 ± 0.032 and 1.963 ± 0.057 mg g(-1)DWbiomass h(-1). Addition of formate improved the MOCs of MMCs, but the dose-response varied for different MMCs. Acetate, nitrate and copper had no significant effect on MOCs, while addition of methanol, ammonium, urea, iron and zinc impacted negatively. Overall, MMCs enriched from marine sediments and landfill top cover soil showed high MOCs which were largely resilient to nutrient supplementation, suggesting a strong potential for biofilter development for industrial low-level CH4 abatement, such as those present in CMV.

  2. Development of tailored indigenous marine consortia for the degradation of naturally weathered polyethylene films

    Science.gov (United States)

    Syranidou, Evdokia; Karkanorachaki, Katerina; Amorotti, Filippo; Repouskou, Eftychia; Kroll, Kevin; Kolvenbach, Boris; Corvini, Philippe F-X; Fava, Fabio

    2017-01-01

    This study investigated the potential of bacterial-mediated polyethylene (PE) degradation in a two-phase microcosm experiment. During phase I, naturally weathered PE films were incubated for 6 months with the indigenous marine community alone as well as bioaugmented with strains able to grow in minimal medium with linear low-density polyethylene (LLDPE) as the sole carbon source. At the end of phase I the developed biofilm was harvested and re-inoculated with naturally weathered PE films. Bacteria from both treatments were able to establish an active population on the PE surfaces as the biofilm community developed in a time dependent way. Moreover, a convergence in the composition of these communities was observed towards an efficient PE degrading microbial network, comprising of indigenous species. In acclimated communities, genera affiliated with synthetic (PE) and natural (cellulose) polymer degraders as well as hydrocarbon degrading bacteria were enriched. The acclimated consortia (indigenous and bioaugmented) reduced more efficiently the weight of PE films in comparison to non-acclimated bacteria. The SEM images revealed a dense and compact biofilm layer and signs of bio-erosion on the surface of the films. Rheological results suggest that the polymers after microbial treatment had wider molecular mass distribution and a marginally smaller average molar mass suggesting biodegradation as opposed to abiotic degradation. Modifications on the surface chemistry were observed throughout phase II while the FTIR profiles of microbially treated films at month 6 were similar to the profiles of virgin PE. Taking into account the results, we can suggest that the tailored indigenous marine community represents an efficient consortium for degrading weathered PE plastics. PMID:28841722

  3. Development of tailored indigenous marine consortia for the degradation of naturally weathered polyethylene films.

    Science.gov (United States)

    Syranidou, Evdokia; Karkanorachaki, Katerina; Amorotti, Filippo; Repouskou, Eftychia; Kroll, Kevin; Kolvenbach, Boris; Corvini, Philippe F-X; Fava, Fabio; Kalogerakis, Nicolas

    2017-01-01

    This study investigated the potential of bacterial-mediated polyethylene (PE) degradation in a two-phase microcosm experiment. During phase I, naturally weathered PE films were incubated for 6 months with the indigenous marine community alone as well as bioaugmented with strains able to grow in minimal medium with linear low-density polyethylene (LLDPE) as the sole carbon source. At the end of phase I the developed biofilm was harvested and re-inoculated with naturally weathered PE films. Bacteria from both treatments were able to establish an active population on the PE surfaces as the biofilm community developed in a time dependent way. Moreover, a convergence in the composition of these communities was observed towards an efficient PE degrading microbial network, comprising of indigenous species. In acclimated communities, genera affiliated with synthetic (PE) and natural (cellulose) polymer degraders as well as hydrocarbon degrading bacteria were enriched. The acclimated consortia (indigenous and bioaugmented) reduced more efficiently the weight of PE films in comparison to non-acclimated bacteria. The SEM images revealed a dense and compact biofilm layer and signs of bio-erosion on the surface of the films. Rheological results suggest that the polymers after microbial treatment had wider molecular mass distribution and a marginally smaller average molar mass suggesting biodegradation as opposed to abiotic degradation. Modifications on the surface chemistry were observed throughout phase II while the FTIR profiles of microbially treated films at month 6 were similar to the profiles of virgin PE. Taking into account the results, we can suggest that the tailored indigenous marine community represents an efficient consortium for degrading weathered PE plastics.

  4. Microbial ecology of a novel sulphur cycling consortia from AMD: implications for acid generation

    Science.gov (United States)

    Loiselle, L. M.; Norlund, K. L.; Hitchcock, A. P.; Warren, L. A.

    2009-05-01

    Recent work1 identified a novel microbial consortia consisting of two bacterial strains common to acid mine drainage (AMD) environments (autotrophic sulphur oxidizer Acidithiobacillus ferrooxidans and heterotrophic Acidiphilium spp.) in an environmental enrichment from a mine tailings lake. The two strains showed a specific spatial arrangement within an EPS macrostructure or "pod" allowing linked metabolic redox cycling of sulphur. Sulphur species characterisation of the pods using scanning transmission X-ray microscopy (STXM) indicated that autotrophic tetrathionate disproportionation by A. ferrooxidans producing colloidal elemental sulphur (S0) is coupled to heterotrophic S0 reduction by Acidiphilium spp. Geochemical modelling of the microbial sulphur reactions indicated that if they are widespread in AMD environments, then global AMD-driven CO2 liberation from mineral weathering have been overestimated by 40-90%1. Given the common co-occurrence of these two bacteria in AMD settings, the purpose of this study was to evaluate if these pods could be induced in the laboratory by pure strains and if so, whether their combined sulphur geochemistry mimicked the previous findings. Laboratory batch experiments assessed the development of pods with pure strain type cultures (A. ferrooxidans ATCC 19859 with mixotroph Acidiphilium acidophilum ATCC 738 or strict heterotroph Acp. cryptum ATCC 2158) using fluorescent in situ hybridization (FISH) imaging. The microbial sulphur geochemistry was characterized under autotrophic conditions identical to those used with the environmental AMD enrichment in which the pods were discovered. Results showed that the combined pure strain A. ferrooxidans and Acp. acidophilum form pods identical in structure to the AMD enrichment. To test the hypothesis that these pods form for mutual metabolic benefit, experiments were performed amending pure strain and AMD enrichment bacterial treatments with organic carbon and/or additional sulphur to

  5. The herbaceous landlord: integrating the effects of symbiont consortia within a single host

    Directory of Open Access Journals (Sweden)

    Roo Vandegrift

    2015-11-01

    Full Text Available Plants are typically infected by a consortium of internal fungal associates, including endophytes in their leaves, as well as arbuscular mycorrhizal fungi (AMF and dark septate endophytes (DSE in their roots. It is logical that these organisms will interact with each other and the abiotic environment in addition to their host, but there has been little work to date examining the interactions of multiple symbionts within single plant hosts, or how the relationships among symbionts and their host change across environmental conditions. We examined the grass Agrostis capillaris in the context of a climate manipulation experiment in prairies in the Pacific Northwest, USA. Each plant was tested for presence of foliar endophytes in the genus Epichloë, and we measured percent root length colonized (PRLC by AMF and DSE. We hypothesized that the symbionts in our system would be in competition for host resources, that the outcome of that competition could be driven by the benefit to the host, and that the host plants would be able to allocate carbon to the symbionts in such a way as to maximize fitness benefit within a particular environmental context. We found a correlation between DSE and AMF PRLC across climatic conditions; we also found a fitness cost to increasing DSE colonization, which was negated by presence of Epichloë endophytes. These results suggest that selective pressure on the host is likely to favor host/symbiont relationships that structure the community of symbionts in the most beneficial way possible for the host, not necessarily favoring the individual symbiont that is most beneficial to the host in isolation. These results highlight the need for a more integrative, systems approach to the study of host/symbiont consortia.

  6. Enrichment of highly settleable microalgal consortia in mixed cultures for effluent polishing and low-cost biomass production.

    Science.gov (United States)

    Hu, Yuansheng; Hao, Xiaodi; van Loosdrecht, Mark; Chen, Huiqin

    2017-08-15

    Microalgae cultivation is a promising technology for integrated effluent polishing and biofuel production, but poor separability of microalgal cells hinders its industrial application. This study intended to selectively enrich settleable microalgal consortia in mixed culture by applying "wash-out" pressure, which was realized by controlling settling time (ST) and volume exchange ratio (VER) in photo-SBRs. The results demonstrated that highly settleable microalgal consortia (settling efficiency>97%; SVI = 17-50 mL/g) could be enriched from indigenous algal cultures developed in WWTP's effluent. High VER was the key factor for the fast development of settleable microalgae. VER was also a controlling factor of the algal community structure. High VERs (0.5 and 0.7) resulted in the dominance of diatom, while low VER (0.2) facilitated the dominance of cyanobacteria. The settleable microalgal consortia were very efficient in phosphorus removal (effluent PO4(3-)-P99%), which was largely attributed to intensive chemical precipitation of phosphate induced by high pH (8.5-10). However, the high pH decreased the bioavailable inorganic carbon, resulting in incomplete nitrate removal (effluent NO3(-)-N = 2.2-4 mg/L; removal efficiency = 61-79%) under high VERs and low lipid content (up to 10%) in the settleable microalgae. This problem could be resolved by sparging CO2 or controlling pH. Overall, this study demonstrated a simple and effective method to overcome the separation challenge in scale-up of microalgae biotechnology for advanced wastewater purification and biofuel production. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Biosurfactant production from marine hydrocarbon-degrading consortia and pure bacterial strains using crude oil as carbon source

    Directory of Open Access Journals (Sweden)

    Eleftheria eAntoniou

    2015-04-01

    Full Text Available Biosurfactants (BS are green amphiphilic molecules produced by microorganisms during biodegradation, increasing the bioavailability of organic pollutants. In this work, the BS production yield of marine hydrocarbon degraders isolated from Elefsina bay in Eastern Mediterranean Sea has been investigated. The drop collapse test was used as a preliminary screening test to confirm biosurfactant producing strains or mixed consortia. The community structure of the best consortia based on the drop collapse test was determined by 16S-rDNA pyrotag screening. Subsequently, the effect of incubation time, temperature, substrate and supplementation with inorganic nutrients, on biosurfactant production, was examined. Two types of BS - lipid mixtures were extracted from the culture broth; the low molecular weight BS Rhamnolipids and Sophorolipids. Crude extracts were purified by silica gel column chromatography and then identified by thin layer chromatography (TLC and Fourier transform infrared spectroscopy (FT-IR. Results indicate that biosurfactant production yield remains constant and low while it is independent of the total culture biomass, carbon source, and temperature. A constant BS concentration in a culture broth with continuous degradation of crude oil implies that the BS producing microbes generate no more than the required amount of biosurfactants that enables biodegradation of the crude oil. Isolated pure strains were found to have higher specific production yields than the complex microbial marine community-consortia. The heavy oil fraction of crude oil has emerged as a promising substrate for BS production (by marine BS producers with fewer impurities in the final product. Furthermore, a particular strain isolated from sediments, Paracoccus marcusii, may be an optimal choice for bioremediation purposes as its biomass remains trapped in the hydrocarbon phase, not suffering from potential dilution effects by sea currents.

  8. 78 FR 52535 - Withdrawal of Approval of New Animal Drug Applications; Quali-Tech Products, Inc.; Bambermycins...

    Science.gov (United States)

    2013-08-23

    ...; Quali- Tech Products, Inc.; Bambermycins; Pyrantel; Tylosin; Virginiamycin AGENCY: Food and Drug... feeds, are no longer manufactured or marketed: NADA 097-980 for Quali-Tech TYLAN-10 (tylosin...

  9. Construction of Innovative Rural Sci-tech Service System in China

    Institute of Scientific and Technical Information of China (English)

    Xinyue; LI; Qiwei; DAI

    2013-01-01

    At the background of structural regulation of agriculture and industrialized development of rural areas,systematic thought and constructive recommendations are put forward on building innovative rural sci-tech service system in China from following 5 aspects. (1) In organizational system,rural sci-tech service associations should become nonprofit organizations that have independent legal entities. (2) In service object,it should take farmers as subject,new rural economic organizations as carrier,agricultural leading enterprises as handle,little village officials as joint,sci-tech special commissioner as link,and agricultural brokers as medium. (3) In information resources,it should enhance practicality construction and sharing. (4) In service methods and reform measures,it should combine information technology,expert technical consulting service,and sci-tech model base. (5) In policy support and input mechanism,it should follow the principle of diversification,set up government special funds,and formulate preferential policies to attract sci-tech talents to join in rural sci-tech services,and protect legal rights and interests of sci-tech personnel in rural sci-tech services.

  10. Do gender and personality traits (BFI-10) influence self-perceived tech savviness?

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    2015-01-01

    Nowadays, it is necessary to use technology in various everyday activities. A certain level of what used to be called high-tech savviness is needed to access certain services. The aim of this paper is to analyze if gender and personality traits (Big Five Inventory-10) influence self-perceived tech...

  11. A Decision Support System for Identification and Evaluation of High-tech Products

    Institute of Scientific and Technical Information of China (English)

    GAO Chang-yuan; LIANG Jing-guo; CAO Xiu-ying

    2002-01-01

    According to high-tech product features and decision support system theory, a decision support system (DSS) for identification and evaluation of high-tech products has been designed which consists of the user interface subsystem, the data management subsystem, the model management subsystem and the knowledge management subsystem. This paper describes the function and the framework of the system.

  12. State of FinTech in Europe: Mutation perspectives of the banking sector

    OpenAIRE

    Marasco, Marco

    2017-01-01

    This paper studies the relationship between FinTech start-ups and the banking sector. The aim is to assess the impact that the FinTech sector might have on the business model and profitability of banks. Master [120] en sciences de gestion (Mons), Université catholique de Louvain, 2017

  13. When High Tech ceases to be High Growth: The Loss of Dynamism of the Cambridgeshire Regio

    NARCIS (Netherlands)

    Stam, E.; Martin, R.

    2012-01-01

    This paper analyses mechanisms of decline and renewal in high-tech regions, illustrated with empirical evidence on the Cambridgeshire high-tech region in the UK. The paper contributes to ecological (‘carrying capacity’) and evolutionary (path dependence) theories of regional development. It provides

  14. GATE Center for Automotive Fuel Cell Systems at Virginia Tech

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Douglas [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)

    2011-09-30

    The Virginia Tech GATE Center for Automotive Fuel Cell Systems (CAFCS) achieved the following objectives in support of the domestic automotive industry: Expanded and updated fuel cell and vehicle technologies education programs; Conducted industry directed research in three thrust areas development and characterization of materials for PEM fuel cells; performance and durability modeling for PEM fuel cells; and fuel cell systems design and optimization, including hybrid and plug-in hybrid fuel cell vehicles; Developed MS and Ph.D. engineers and scientists who are pursuing careers related to fuel cells and automotive applications; Published research results that provide industry with new knowledge which contributes to the advancement of fuel cell and vehicle systems commercialization. With support from the Dept. of Energy, the CAFCS upgraded existing graduate course offerings; introduced a hands-on laboratory component that make use of Virginia Tech's comprehensive laboratory facilities, funded 15 GATE Fellowships over a five year period; and expanded our program of industry interaction to improve student awareness of challenges and opportunities in the automotive industry. GATE Center graduate students have a state-of-the-art research experience preparing them for a career to contribute to the advancement fuel cell and vehicle technologies.

  15. A novel technology for quick acclimation of an anaerobic microbial consortia used for biodegrading teraphthalic acid(TA)

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The seed sludge originated from a methane fermentation reactor was enriched and acclimated with TA as sole carbon source under nitrate respiration mode first for 6 week, and then can be turned to methane fermentation conditions. After 6 weeks processing, the specific rate acclimation. Aftera total of 90 days for the enrichment and acclimation, the fermentative bacteria which originally existed in the seed sludge nearly disappeared, and instead of them, the TA reductive and cleaving bacteria group was formed in the new consortia, which was confirmed by the MPN counts and roll tube counts. Compared with the control experiment, the acclimation period can be shortened by about 50%.

  16. The effects of a prenatal course including PREP for effective family living on self-esteem and parenting attitudes of adolescents: a brief report.

    Science.gov (United States)

    Emmons, R D; Nystul, M S

    1994-01-01

    Nine adolescent females were enrolled in a prenatal course that included the PREP for Effective Family Living Program (the treatment group). Two comparison groups were utilized in this study; one attended the prenatal group without the PREP program, and the second did not attend either the prenatal course or the PREP program. The Coopersmith Self-Esteem Inventory and the Attitude Toward the Freedom of Children Scale (a parental attitude scale) was administered to all participants. No significant difference was found among the three groups in terms of self-concept. A significant difference was found among the three groups in terms of parental attitudes, with the treatment group scoring higher on democratic parenting attitudes than did the two comparison groups.

  17. Study on Management System for Agricultural Sci-tech Achievement Transformation Funding Project

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Hong; YU; Jun

    2013-01-01

    Relying on the management system for agricultural sci-tech achievement transformation funding project in Zhejiang Province, on the basis of current situations and demand of agricultural sci-tech achievement transformation funding project management system, we present a B/S-structured and J2EE platform-based system which adopts MVC mode and integrates mainstream open-source frame technologies such as Spring, Struts2, ExtJs, TopLink and FreeMarker, etc. Practice has shown that this system provides an original model for management of sci-tech project application, and various projects can be expanded on this model. With the aid of this system, sci-tech project management personnel can be relieved from trivial manual works, so as to increase working efficiency and improve management level of sci-tech project management.

  18. Competitive low-tech manufacturing and challenges for regional policy in the European context

    DEFF Research Database (Denmark)

    Hansen, Teis; Winther, Lars

    2014-01-01

    Today, low-tech firms in high-wage countries are focusing on increasing investments in highly skilled labour and advanced machinery, incremental innovation and high value-added niches. Danish policy, however, gives little attention to the new specificities of low-tech manufacturing, and the under....... Conversely, user–producer interactions and machinery investments, which are critical to low-tech competitiveness, are disregarded by policies.......Today, low-tech firms in high-wage countries are focusing on increasing investments in highly skilled labour and advanced machinery, incremental innovation and high value-added niches. Danish policy, however, gives little attention to the new specificities of low-tech manufacturing...

  19. Chem-Prep PZT 95/5 for neutron generator applications : development of laboratory-scale powder processing operations.

    Energy Technology Data Exchange (ETDEWEB)

    Montoya, Ted V.; Moore, Roger Howard; Spindle, Thomas Lewis Jr.

    2003-12-01

    Chemical synthesis methods are being developed as a future source of PZT 95/5 powder for neutron generator voltage bar applications. Laboratory-scale powder processes were established to produce PZT billets from these powders. The interactions between calcining temperature, sintering temperature, and pore former content were studied to identify the conditions necessary to produce PZT billets of the desired density and grain size. Several binder systems and pressing aids were evaluated for producing uniform sintered billets with low open porosity. The development of these processes supported the powder synthesis efforts and enabled comparisons between different chem-prep routes.

  20. OligoPrep PVA support for oligonucleotide synthesis in columns on a scale up to 10 micromol.

    Science.gov (United States)

    Aitken, Sheena; Anderson, Emma

    2007-01-01

    OligoPrep is a macroporous polyvinylacetate (PVA) biodegradable support that has been designed for cost-effective automated synthesis of oligonucleotides using standard phosphoramidite chemistry. Originally developed for large-scale oligonucleotide synthesis in beds and reactors, we present here its utility for medium-scale work of 1-10 micromol in column syntheses on standard DNA synthesizers. We show how an increase in scale, and, therefore, yield, can be achieved without significant increase in reagent quantity. Additional deblock and oxidation cycles can provide high coupling yields, and the use of concentrated ammonia in aqueous methylamine (AMA) for oligonucleotide cleavage and deprotection results in excellent recovery.

  1. Efectos de una dosis baja de bisfenol A sobre el eje reproductor de ratas machos prepúberes

    OpenAIRE

    Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Ponzo, Osvaldo Juan; Carbone, Silvia Elena; Pandolfi, Matias; Scacchi, Pablo; Reynoso, Roxana María

    2015-01-01

    El objetivo del presente trabajo fue estudiar el efecto de una dosis baja de bisfenol A (BPA) sobre el eje reproductor de ratas macho prepúberes, expuestas durante la gestación y la lactancia. Se trató a ratas hembra preñadas con una dosis aproximada de exposición de BPA de 3 mg, administrado en el agua de bebida, y el tratamiento continuó durante la lactancia. Las crías macho fueron sacrificadas a los 35 días de vida, etapa prepuberal. Se evaluó el peso corporal durante el desarrollo de las...

  2. "I did not want to give birth to a child who has HIV": Experiences using PrEP during pregnancy among HIV-uninfected Kenyan women in HIV-serodiscordant couples.

    Science.gov (United States)

    Pintye, Jillian; Beima-Sofie, Kristin M; Kimemia, Grace; Ngure, Kenneth; Trinidad, Susan Brown; Heffron, Renee; Baeten, Jared; Odoyo, Josephine; Mugo, Nelly; Bukusi, Elizabeth A; Kelley, Maureen C; John-Stewart, Grace C

    2017-07-31

    The perceptions, motivations, and beliefs of HIV-uninfected women about PrEP use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. Semi-structured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy. Interviews were audio-recorded and transcribed into English. A qualitative descriptive analysis was performed, using a constant comparison approach to identify key themes related to PrEP use in pregnancy. Desire to remain HIV-uninfected and have an HIV-free infant were strong motivators influencing continued use of PrEP during pregnancy. Supporting HIV-infected partners and childbearing within an HIV-serodiscordant relationship were also motivators. Women had challenges distinguishing normal pregnancy symptoms from PrEP side effects and were concerned that observed side effects could be signs of danger for the infant related to PrEP exposure. Healthcare providers were important conduits of knowledge about PrEP, and continuity of PrEP providers throughout pregnancy facilitated adherence. HIV-uninfected women in HIV-serodiscordant couples were motivated to use PrEP during pregnancy to remain HIV-uninfected and to have an HIV-free child, but had concerns about side effects. Healthcare providers will be important for PrEP messaging and adherence support in this unique population.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without

  3. Intimate Partner Violence and Adherence to HIV Pre-exposure Prophylaxis (PrEP) in African Women in HIV Serodiscordant Relationships: A Prospective Cohort Study.

    Science.gov (United States)

    Roberts, Sarah T; Haberer, Jessica; Celum, Connie; Mugo, Nelly; Ware, Norma C; Cohen, Craig R; Tappero, Jordan W; Kiarie, James; Ronald, Allan; Mujugira, Andrew; Tumwesigye, Elioda; Were, Edwin; Irungu, Elizabeth; Baeten, Jared M

    2016-11-01

    Intimate partner violence (IPV) is associated with higher HIV incidence, reduced condom use, and poor adherence to antiretroviral therapy and other medications. IPV may also affect adherence to pre-exposure prophylaxis (PrEP). We analyzed data from 1785 HIV-uninfected women enrolled in a clinical trial of PrEP among African HIV serodiscordant couples. Experience of verbal, physical, or economic IPV was assessed at monthly visits by face-to-face interviews. Low PrEP adherence was defined as clinic-based pill count coverage <80% or plasma tenofovir levels <40 ng/mL. The association between IPV and low adherence was analyzed using generalized estimating equations, adjusting for potential confounders. In-depth interview transcripts were examined to explain how IPV could impact adherence. Sixteen percent of women reported IPV during a median of 34.8 months of follow-up (interquartile range 27.0-35.0). Overall, 7% of visits had pill count coverage <80%, and 32% had plasma tenofovir <40 ng/mL. Women reporting IPV in the past 3 months had increased risk of low adherence by pill count (adjusted risk ratio 1.49, 95% confidence interval: 1.17 to 1.89) and by plasma tenofovir (adjusted risk ratio 1.51, 95% confidence interval: 1.06 to 2.15). Verbal, economic, and physical IPV were all associated with low adherence. However, the impact of IPV diminished and was not statistically significant 3 months after the reported exposure. In qualitative interviews, women identified several ways in which IPV affected adherence, including stress and forgetting, leaving home without pills, and partners throwing pills away. Women who reported recent IPV in the Partners PrEP Study were at increased risk of low PrEP adherence. Strategies to mitigate PrEP nonadherence in the context of IPV should be evaluated.

  4. The Dimensional Analysis of Library Consortia Innovation Networks%图书馆联盟创新关系网络维度分析

    Institute of Scientific and Technical Information of China (English)

    郭文静

    2016-01-01

    〔Abstract〕 There is voluntarily or involuntarily high frequency and intensive interaction between libraries within the library consortia. Such interaction constitutes a complex network of relationships within innovation library consortia, so that the synergies between will continue to enhance, let library consortia more competitive and cohesive. From the social, structural, knowledge three dimensions innovation in the library consortia for network analysis, learn unique and innovative library consortia networks, and to study the three dimensions of the role of innovation for the entire library consortia, respectively, according to the proposed strengthening suggestions business relationships.%图书馆联盟内外部存在各种各样的互动活动,这些密集的活动中既有自愿的,也有非自愿的。图书馆联盟的创新关系网络是在互动活动基础上形成的,这是成员间增强协同效应的主要途径,更是提高图书馆联盟竞争力和凝聚力的重要方式。文章在从社会、结构、知识三个维度分析了图书馆联盟创新关系网络的基础上,着重探讨了基于上述三个维度的创新关系网络对图书馆联盟创新的重要作用,并提出强化图书馆联盟成员间关系的对策和建议。

  5. a Study on the Document Information Service of the National Agricultural Library for Agricultural Sci-Tech Innovation in China

    Science.gov (United States)

    Xu, Qian; Meng, Xianxue

    This paper presents the significant function of the Chinese National Agricultural Library (CNAL) in the agricultural sci-tech innovation system in China, analyses the development of collection and service in the CNAL, explores the challenge towards sustain and develop information services for the agricultural sci-tech research and innovation, at last proposes the strategy for sci-tech document information service development.

  6. 75 FR 21663 - Maysteel, LLC Including On-Site Leased Workers From Staff One, Badger Tech, Boyd Hunter, Seek...

    Science.gov (United States)

    2010-04-26

    ... Tech, Boyd Hunter, Seek, QPS, and Service First, Menomonee Falls, WI; Amended Certification Regarding..., including on-site leased workers from Staff One, Badger Tech, Boyd Hunter, Seek, and QPS, Menomonee Falls... Maysteel, LLC, including on-site leased workers from Staff One, Badger Tech, Boyd Hunter, Seek, QPS,...

  7. High-Tech Means High-Efficiency: The Business Case for EnergyManagement in High-Tech Industries

    Energy Technology Data Exchange (ETDEWEB)

    Shanshoian, Gary; Blazek, Michele; Naughton, Phil; Seese, RobertS.; Mills, Evan; Tschudi, William

    2005-11-15

    In the race to apply new technologies in ''high-tech'' facilities such as data centers, laboratories, and clean rooms, much emphasis has been placed on improving service, building capacity, and increasing speed. These facilities are socially and economically important, as part of the critical infrastructure for pharmaceuticals,electronics, communications, and many other sectors. With a singular focus on throughput, some important design issues can be overlooked, such as the energy efficiency of individual equipment (e.g., lasers, routers and switches) as well as the integration of high-tech equipment into the power distribution system and the building envelope. Among technology-based businesses, improving energy efficiency presents an often untapped opportunity to increase profits, enhance process control,maximize asset value, improve the work place environment, and manage a variety of business risks. Oddly enough, the adoption of energy efficiency improvements in this sector lags behind many others. As a result, millions of dollars are left on the table with each year ofoperation.

  8. The Cobas AmpliPrep/Cobas TaqMan HCV Test, Version 2.0, Real-Time PCR Assay Accurately Quantifies Hepatitis C Virus Genotype 4 RNA

    OpenAIRE

    Chevaliez, Stéphane; Bouvier-Alias, Magali; Rodriguez, Christophe; Soulier, Alexandre; Poveda, Jean-Dominique; Pawlotsky, Jean-Michel

    2013-01-01

    Accurate hepatitis C virus (HCV) RNA quantification is mandatory for the management of chronic hepatitis C therapy. The first-generation Cobas AmpliPrep/Cobas TaqMan HCV test (CAP/CTM HCV) underestimated HCV RNA levels by >1-log10 international units/ml in a number of patients infected with HCV genotype 4 and occasionally failed to detect it. The aim of this study was to evaluate the ability of the Cobas AmpliPrep/Cobas TaqMan HCV test, version 2.0 (CAP/CTM HCV v2.0), to accurately quantify H...

  9. Clostridium huakuii sp. nov., an anaerobic, acetogenic bacterium isolated from methanogenic consortia.

    Science.gov (United States)

    Ruan, Zhiyong; Wang, Yanwei; Zhang, Chi; Song, Jinlong; Zhai, Yi; Zhuang, Yan; Wang, Huimin; Chen, Xiaorong; Li, Yanting; Zhao, Bingqiang; Zhao, Bin

    2014-12-01

    A Gram-staining-positive, spore-forming, obligately anaerobic, acetogenic bacterium, designated LAM1030(T), was isolated from methanogenic consortia enriched from biogas slurry collected from the large-scale anaerobic digester of Modern Farming Corporation in Hebei Province, China. Cells of strain LAM1030(T) were motile, straight or spiral-rod-shaped. Strain LAM1030(T) could utilize glucose, fructose, maltose, galactose, lactose, sucrose, cellobiose, mannitol, pyruvate, succinic acid and tryptophan as the sole carbon source. Acetic acid, isovaleric acid and butanoic acid were the main products of glucose fermentation. Sodium sulfite was used as an electron acceptor. Growth of strain LAM1030(T) was completely inhibited by the addition of ampicillin, tetracycline, gentamicin or erythromycin at a concentration of 20 µg ml(-1). The main polar lipids of strain LAM1030(T) were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, 11 unknown glycolipids and two unknown phospholipids. No respiratory quinone was detected. The major fatty acids of strain LAM1030(T) were C16 : 0 (21.1 %), C14 : 0 (10.3 %), summed feature 9 (including C16:0 10-methyl and/or iso-C17:1 ω9c) (11.3% ), summed feature 3 (including C16:1 ω7c and/or C16:1 ω6c) (10.6% ) and iso-C15 : 0 (6.6 %). Analysis of the 16S rRNA gene sequence indicated that strain LAM1030(T) belonged to the genus Clostridium and was most closely related to Clostridium subterminale DSM 6970(T), Clostridium thiosulfatireducens DSM 13105(T) and Clostridium sulfidigenes DSM 18982(T), with 97.0, 96.9 and 96.8 % similarity, respectively. The G+C content of the genomic DNA of strain LAM1030(T) was 31.2±0.3 mol%. On the basis of its phenotypic, phylogenetic and chemotaxonomic characterization, strain LAM1030(T) is suggested to represent a novel species of the genus Clostridium, for which the name Clostridium huakuii sp. nov. is proposed. The type strain is LAM1030(T) ( = ACCC 00698(T

  10. Transformation of Swine Manure and Algal Consortia to Value-added Products

    Science.gov (United States)

    Sharara, Mahmoud A.

    The swine production sector is projected to grow globally. In the past, this growth manifested itself in increased herd sizes and geographically concentrated production. Although economically sound, these trends had negative consequences on surrounding ecosystems. Over-application of manure resulted in water quality degradation, while long-term storage of manure slurries was found to promote release of potent GHG emissions. There is a need for innovative approaches for swine manure management that are compatible with current scales of production, and increasingly strict environmental regulations. This study aims to investigate the potential for incorporating gasification as part of a novel swine manure management system which utilizes liquid-solid separation and periphytic algal consortia as a phycoremediation vector for the liquid slurry. The gasification of swine manure solids, and algal biomass solids generate both a gaseous fuel product (producer gas) in addition to a biochar co-product. First, the decomposition kinetics for both feedstock, i.e., swine manure solids, and algal solids, were quantified using thermogravimetry at different heating rates (1 ~ 40°C min-1) under different atmospheres (nitrogen, and air). Pyrolysis kinetics were determined for manure solids from two farms with different manure management systems. Similarly, the pyrolysis kinetics were determined for phycoremediation algae grown on swine manure slurries. Modeling algal solids pyrolysis as first-order independent parallel reactions was sufficient to describe sample devolatilization. Combustion of swine manure solids blended with algal solids, at different ratios, showed no synergistic effects. Gasification of phycoremediation algal biomass was studied using a bench-scale auger gasification system at temperatures between 760 and 960°C. The temperature profile suggested a stratification of reaction zones common to fixed-bed reactors. The producer gas heating value ranged between 2.2 MJ m

  11. Developmental plasticity of bacterial colonies and consortia in germ-free and gnotobiotic settings

    Directory of Open Access Journals (Sweden)

    Pátková Irena

    2012-08-01

    Full Text Available Abstract Background Bacteria grown on semi-solid media can build two types of multicellular structures, depending on the circumstances. Bodies (colonies arise when a single clone is grown axenically (germ-free, whereas multispecies chimeric consortia contain monoclonal microcolonies of participants. Growth of an axenic colony, mutual interactions of colonies, and negotiation of the morphospace in consortial ecosystems are results of intricate regulatory and metabolic networks. Multicellular structures developed by Serratia sp. are characteristically shaped and colored, forming patterns that reflect their growth conditions (in particular medium composition and the presence of other bacteria. Results Building on our previous work, we developed a model system for studying ontogeny of multicellular bacterial structures formed by five Serratia sp. morphotypes of two species grown in either "germ-free" or "gnotobiotic" settings (i.e. in the presence of bacteria of other conspecific morphotype, other Serratia species, or E. coli. Monoclonal bodies show regular and reproducible macroscopic appearance of the colony, as well as microscopic pattern of its growing margin. Standard development can be modified in a characteristic and reproducible manner in close vicinity of other bacterial structures (or in the presence of their products. Encounters of colonies with neighbors of a different morphotype or species reveal relationships of dominance, cooperation, or submission; multiple interactions can be summarized in "rock – paper – scissors" network of interrelationships. Chimerical (mixed plantings consisting of two morphotypes usually produced a “consortium” whose structure is consistent with the model derived from interaction patterns observed in colonies. Conclusions Our results suggest that development of a bacterial colony can be considered analogous to embryogenesis in animals, plants, or fungi: to proceed, early stages require thorough

  12. Petascale Simulation Initiative Tech Base: FY2007 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    May, J; Chen, R; Jefferson, D; Leek, J; Kaplan, I; Tannahill, J

    2007-10-26

    The Petascale Simulation Initiative began as an LDRD project in the middle of Fiscal Year 2004. The goal of the project was to develop techniques to allow large-scale scientific simulation applications to better exploit the massive parallelism that will come with computers running at petaflops per second. One of the major products of this work was the design and prototype implementation of a programming model and a runtime system that lets applications extend data-parallel applications to use task parallelism. By adopting task parallelism, applications can use processing resources more flexibly, exploit multiple forms of parallelism, and support more sophisticated multiscale and multiphysics models. Our programming model was originally called the Symponents Architecture but is now known as Cooperative Parallelism, and the runtime software that supports it is called Coop. (However, we sometimes refer to the programming model as Coop for brevity.) We have documented the programming model and runtime system in a submitted conference paper [1]. This report focuses on the specific accomplishments of the Cooperative Parallelism project (as we now call it) under Tech Base funding in FY2007. Development and implementation of the model under LDRD funding alone proceeded to the point of demonstrating a large-scale materials modeling application using Coop on more than 1300 processors by the end of FY2006. Beginning in FY2007, the project received funding from both LDRD and the Computation Directorate Tech Base program. Later in the year, after the three-year term of the LDRD funding ended, the ASC program supported the project with additional funds. The goal of the Tech Base effort was to bring Coop from a prototype to a production-ready system that a variety of LLNL users could work with. Specifically, the major tasks that we planned for the project were: (1) Port SARS [former name of the Coop runtime system] to another LLNL platform, probably Thunder or Peloton (depending

  13. The Robin, Erithacus Rubecula (Passeriformes, Turdidae, as a Component of Heterotrophic Consortia of Forest Cenoses, Northeast Ukraine. Part 2

    Directory of Open Access Journals (Sweden)

    Chaplygina A. B.

    2016-12-01

    Full Text Available The role of the robin as a determinant of heterotrophic consortia is considered. The robin is a consort of determinants of autotrophic consortia, which core is represented mostly by dominating species of deciduous trees (Quercus robur Linnaeus, 1753, Tilia cordata Miller, 1768, Acer platanoides Linnaeus, 1753, Acer campestre Linnaeus, 1753, and also by sedges (Carex sp. and grasses (Poaceae, connected with the determinants by fabric links. The robin also belongs to the concentr of the second and higher orders as a component of forest biogeocenoses and it is also the main determinant in species composition of the insects inhabiting bird nests. As a result of the taxonomic analysis of invertebrates in the robin nests, it has been found out that the most numerous class was Insecta (9 orders and 27 families, with the dominance of Coleoptera (30.7 %. The nidicolous fauna of the robin (38 species was dominated by zoophages along with parasites and hematophages such as Hippoboscidae (46.4 %. The percentage of phytophages and saprophages among the invertebrate nest inhabitants was somewhat less (21 % each, then followed necrophages (12 %. Zoophages and parasites also dominated according to the number of objects in the nests (42 %; n = 150, the less was the portion of phytophages (34 %, saprophages (18 %, and necrophages (6 %. The highest number of species and objects of zoophages was recorded for climax and mature biocenoses (oak forests in NNP “HL” and pine cenoses in NNP “H””.

  14. Geochemical, metagenomic and metaproteomic insights into trace metal utilization by methane-oxidizing microbial consortia in sulphidic marine sediments.

    Science.gov (United States)

    Glass, Jennifer B; Yu, Hang; Steele, Joshua A; Dawson, Katherine S; Sun, Shulei; Chourey, Karuna; Pan, Chongle; Hettich, Robert L; Orphan, Victoria J

    2014-06-01

    Microbes have obligate requirements for trace metals in metalloenzymes that catalyse important biogeochemical reactions. In anoxic methane- and sulphide-rich environments, microbes may have unique adaptations for metal acquisition and utilization because of decreased bioavailability as a result of metal sulphide precipitation. However, micronutrient cycling is largely unexplored in cold (≤ 10°C) and sulphidic (> 1 mM ΣH(2)S) deep-sea methane seep ecosystems. We investigated trace metal geochemistry and microbial metal utilization in methane seeps offshore Oregon and California, USA, and report dissolved concentrations of nickel (0.5-270 nM), cobalt (0.5-6 nM), molybdenum (10-5600 nM) and tungsten (0.3-8 nM) in Hydrate Ridge sediment porewaters. Despite low levels of cobalt and tungsten, metagenomic and metaproteomic data suggest that microbial consortia catalysing anaerobic oxidation of methane (AOM) utilize both scarce micronutrients in addition to nickel and molybdenum. Genetic machinery for cobalt-containing vitamin B12 biosynthesis was present in both anaerobic methanotrophic archaea (ANME) and sulphate-reducing bacteria. Proteins affiliated with the tungsten-containing form of formylmethanofuran dehydrogenase were expressed in ANME from two seep ecosystems, the first evidence for expression of a tungstoenzyme in psychrophilic microorganisms. Overall, our data suggest that AOM consortia use specialized biochemical strategies to overcome the challenges of metal availability in sulphidic environments. © 2013 Society for Applied Microbiology and John Wiley & Sons Ltd.

  15. Effects of inoculation sources on the enrichment and performance of anode bacterial consortia in sensor typed microbial fuel cells

    Directory of Open Access Journals (Sweden)

    Phuong Tran

    2016-01-01

    Full Text Available Microbial fuel cells are a recently emerging technology that promises a number of applications in energy recovery, environmental treatment and monitoring. In this study, we investigated the effect of inoculating sources on the enrichment of electrochemically active bacterial consortia in sensor-typed microbial fuel cells (MFCs. Several MFCs were constructed, operated with modified artificial wastewater and inoculated with different microbial sources from natural soil, natural mud, activated sludge, wastewater and a mixture of those sources. After enrichment, the MFCs inoculated with the natural soil source generated higher and more stable currents (0.53±0.03 mA, in comparisons with the MFCs inoculated with the other sources. The results from denaturing gradient gel electrophoresis (DGGE showed that there were significant changes in bacterial composition from the original inocula to the enriched consortia. Even more interestingly, Pseudomonas sp. was found dominant in the natural soil source and also in the corresponding enriched consortium. The interactions between Pseudomonas sp. and other species in such a community are probably the key for the effective and stable performance of the MFCs.

  16. Geochemical, metagenomic and metaproteomic insights into trace metal utilization by methane-oxidizing microbial consortia in sulphidic marine sediments

    Energy Technology Data Exchange (ETDEWEB)

    Glass, DR. Jennifer [California Institute of Technology, Pasadena; Yu, DR. Hang [California Institute of Technology, Pasadena; Steele, Joshua [California Institute of Technology, Pasadena; Dawson, Katherine [California Institute of Technology, Pasadena; Sun, S [University of California, San Diego; Chourey, Karuna [ORNL; Pan, Chongle [ORNL; Hettich, Robert {Bob} L [ORNL; Orphan, V [California Institute of Technology, Pasadena

    2013-01-01

    Microbes have obligate requirements for trace metals in metalloenzymes that catalyse important biogeochemical reactions. In anoxic methane- and sulphiderich environments, microbes may have unique adaptations for metal acquisition and utilization because of decreased bioavailability as a result of metal sulphide precipitation. However, micronutrient cycling is largely unexplored in cold ( 10 C) and sulphidic (> 1 mM H2S) deep-sea methane seep ecosystems. We investigated trace metal geochemistry and microbial metal utilization in methane seeps offshore Oregon and California, USA, and report dissolved concentrations of nickel (0.5 270 nM), cobalt (0.5 6 nM), molybdenum (10 5600 nM) and tungsten (0.3 8 nM) in Hydrate Ridge sediment porewaters. Despite low levels of cobalt and tungsten, metagenomic and metaproteomic data suggest that microbial consortia catalysing anaerobic oxidation of methane (AOM) utilize both scarce micronutrients in addition to nickel and molybdenum. Genetic machinery for cobalt-containing vitamin B12 biosynthesis was present in both anaerobic methanotrophic archaea (ANME) and sulphate-reducing bacteria. Proteins affiliated with the tungsten-containing form of formylmethanofuran dehydrogenase were expressed in ANME from two seep ecosystems, the first evidence for expression of a tungstoenzyme in psychrophilic microorganisms. Overall, our data suggest that AOM consortia use specialized biochemical strategies to overcome the challenges of metal availability in sulphidic environments.

  17. Evaluating the effectiveness of PrepSTART for promoting oral language and emergent literacy skills in disadvantaged preparatory students.

    Science.gov (United States)

    Lennox, Maria; Westerveld, Marleen F; Trembath, David

    2016-09-19

    This study examined the effectiveness of a classroom-based intervention programme aimed at improving the oral language and emergent literacy skills of students from low socio-economic, culturally diverse backgrounds within their first formal year of schooling ("prep"). Data from 137 students were available for analysis. Participants were from three primary schools located in Queensland, Australia. Eight classes were allocated to intervention and two classes acted as a business as usual control. All students received literacy instruction as per the Australian Curriculum. However, the intervention group received 24 weeks of scripted, classroom-based, book-based intervention targeting code- and meaning-related emergent literacy skills. All students were assessed individually pre- and post-intervention on code-related measures (i.e. letter identification and phonological awareness) and meaning-related measures (i.e. vocabulary, oral narrative comprehension and retell). All students made significant improvement over time for all measures. Students in the intervention group showed significantly more progress than the business as usual group on all measures, except for letter identification and oral narrative comprehension. This classroom-based book-based intervention can improve the code- and meaning-related emergent literacy skills of prep students from low socio-economic backgrounds and provide these students with the building blocks for successful literacy acquisition.

  18. Percentage recovery of dioxin homologue through power-prep according to the eluting solvents and their amounts

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Tae-Uk [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science]|[National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Kim, Dong-Gyu [National Veterinary Research and Quarantine Service (Korea). Seoul Regional Office; Choi, Si-Weon [National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Seo, Dong-Cheol; Jeo, Jong-Soo [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science; Lee, Hong-Jae [Jinju National Univ. (Korea). Dept. of Environmental Engineering

    2004-09-15

    Because of the persistence and accumulation of polychlorinated dibenzo dioxins(PCDDs) and polychlorinated dibenzo furans(PCDFs) in the environment, dioxins contamination is regarded as a global issue. And various methods for analyzing PCDDs and PCDFs have been developed and improved. According to US EPA method, cleanup method was very various. Conventional cleanup methods are very dependable, but are time consuming and use large volumes of organic solvents. To increase the efficiency of cleanup for the analysis of PCDDs and PCDFs, we used high speed automated sample cleanup system for dioxins which is called Power-Prep trademark (Fluid Management System Inc., USA). Power- Prep trademark gave us swift analysis of dioxin and its precision and accuracy. This system was designed to cleanup of toxic compound such as dioxins, PCBs, pesticides and PAHs using silica, alumina and carbon column. Using this system, it is possible to conduct several samples in less than 1.5 hours, thereby, achieving high recoveries and excellent precision and accuracy for all dioxin congeners. In this experiment, we carried out PCDDs and PCDFs analysis by FMS(Fluid Management System Inc.) with 3 eluting solvents such as toluene, hexane and dichloromethane to find out the best eluting solvent and its amounts.

  19. Advanced Polymeric Materials for High-tech Innovations

    Institute of Scientific and Technical Information of China (English)

    TANG; BenZhong

    2001-01-01

    High technology is advancing our society and modernizing our life and advanced materials play an important role in the technological innovations. My research group has been working on the development of advanced polymeric materials and in this talk I will report our recent work on the creation of new conjugated polymers with novel molecular structures and unique materials properties.1-18 Our work include the design of molecular structures of monomeric building blocks, development of stable, effective and environmentally benign "green” polymerization catalysts, discovery of new polymerization reactions, synthesis of functional macromolecules, fabrication of nanodimensional composites, assembly and control of hierarchical structures, and construction of electrooptical devices. We have revealed the liquid crystallinity, light emission, photoconductivity, optical limiting, nano-hybridization, solvatochromism, optical activity, self-organization, and biological activity of the linear polyacetylenes and hyperbranched polyarylenes. The utilization of the advanced polymers and their interesting materials properties for high-tech innovations will be discussed.  ……

  20. PREFACE: Modern Technologies in Industrial Engineering (ModTech2015)

    Science.gov (United States)

    Oanta, E.; Comaneci, R.; Carausu, C.; Placzek, M.; Cohal, V.; Topala, P.; Nedelcu, D.

    2015-11-01

    The dominant feature of the current stage of society development is the update, refinement and innovation of the technological processes and products whose ultimate goal is to satisfy the market requirements. New and modern technologies should be considered in terms of their applicability in industry while the materials can lead to an increase in the quality of the end products. Replacing the existing technologies with innovative and eco-efficient technologies can contribute to an added value increase in the production of new materials. Materials are one of the most dynamic and prospective fields, with applications in all other fields. The development of new advanced materials and technologies shall contribute to the procurement of a wide range of reliable products, with competitive prices and worldwide performance, high sensitivity and functionality, user-friendly and reduced energy consumption, for different industrial applications. Research in the field of advanced/intelligent materials supposes a fundamental, experimental, laboratory and technological research and its approach has to be linked to the application. This involves, even for the niche fields, complex projects which result in scientific issues in top journals, patents and functional models. The third edition of ModTech International Conference was held in Mamaia, Romania, between June 17-20, with the Professional Association in Modern Manufacturing Technologies, ModTech, as main organizer, and the Constanta Maritime University, Constanta, Romania, Silesian University of Technology, Gliwice, Poland, the Technical University of Chisinau, Republic of Moldova and the Donetsk National Technical University, Donetsk, Ukraine as co-organizers. The ModTech2015 International Conference brought together representatives of technology and materials manufacturers, various universities, professional associations and research institutes that exchanged the latest knowledge on the conference topics. This edition was

  1. Knowledge acquisition and creation in the high-tech industry

    Directory of Open Access Journals (Sweden)

    Juliano Pavanelli Stefanovitz

    2007-10-01

    Full Text Available This paper explores the new challenges that come with the emergence of knowledge-based approaches on organizational studies. It is widely recognized, in this context, the increasing importance of understanding the processes through which companys acquire, storage, disseminate and create knowledge. This research analysis the knowledge creation and external acquisition processes in the high-tech industry, environment in which intensive use of knowledge is made. For that, it presents a case study of an R&D Division of a company present in the industrial automation market. In recognition of its innovative competence, this company won the FINEP Prize – Technological Innovation. In this study, besides the identification of the main external knowledge sources, an analysis of the knowledge types conversion observed in its product development activities is made.

  2. Power quality in high-tech campus: a case study

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Munoz, A.; Redel, M.; Gonzalez, M. [Universidad de Cordoba (Spain). Departamento de Electrotecnia y Electronica

    2006-07-01

    This paper presents preliminary results from a power-quality audit conducted at a high-tech campus over the last year. Voltage and current were measured at various R and D buildings; it was found that the main problems for the equipment installed were voltage sags and surges. The paper examines the causes and effects of power disturbances that affect computer or any other microprocessor-based equipment and analyses the auto-protection capabilities of modern power supplies. The convenience of 'enhanced power supply' or 'low-cost customer-side' protection solutions is also discussed. Finally, it addresses the role of the standards on the protection of electronic equipment and the implications for the final customer. (author)

  3. Advanced Polymeric Materials for High-tech Innovations

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ High technology is advancing our society and modernizing our life and advanced materials play an important role in the technological innovations. My research group has been working on the development of advanced polymeric materials and in this talk I will report our recent work on the creation of new conjugated polymers with novel molecular structures and unique materials properties.1-18 Our work include the design of molecular structures of monomeric building blocks, development of stable, effective and environmentally benign "green” polymerization catalysts, discovery of new polymerization reactions, synthesis of functional macromolecules, fabrication of nanodimensional composites, assembly and control of hierarchical structures, and construction of electrooptical devices. We have revealed the liquid crystallinity, light emission, photoconductivity, optical limiting, nano-hybridization, solvatochromism, optical activity, self-organization, and biological activity of the linear polyacetylenes and hyperbranched polyarylenes. The utilization of the advanced polymers and their interesting materials properties for high-tech innovations will be discussed.

  4. Hi-tech products marketing and competitive advantage

    Directory of Open Access Journals (Sweden)

    Perović Jelena

    2004-01-01

    Full Text Available The company today, in causes turbulent environment and intensive integrations must cooperate, accept and develop high technology in order to achieve needs of customers. It's only way that companies replay on challenge global environment, decrease costs of investment per capita, decrease the risk, captivate new market and held competitive in causes of global market. High tech technology marketing function is help that results of new technology transfer on economy. Their function is reach need of customers, too. Positive influence of technology is the highest in area of production costs and productivity. Speed years are in front of our and it demands larger productivity, which primary source must be technology changes. High technology marketing is the most provocative framework for take competitive advantage, answer on global change and way of permanent reach rigorous need of customers.

  5. Emerging technologies in ANC at VAL-Virginia Tech

    Science.gov (United States)

    Johnson, Marty; Fuller, Chris; Homma, Kenji

    2003-10-01

    This presentation will overview the development and application of three new active noise control technologies at VAL-Virginia Tech. Distributed Active Vibration Absorbers (DAVAs) consist of large area spring elements with embedded active elements and covered with a dynamic mass layer. Development of conformal DAVAs and their application to noise control in aircraft and launch vehicle fairings will be overviewed. New work in applying active control techniques to developing virtual acoustic systems and its application to virtual prototyping and virtual reality applications will be discussed. The development a modular, compact active noise control duct which utilizes very small active sources, transducers and a cost effective controller to reducing the total radiated sound from small fans will be presented. The application of the modular ANC duct to a small computer cooling fan will be presented.

  6. Research on the competitiveness of high-tech industries in northeast China

    Science.gov (United States)

    Liu, Lei; Wang, Yang; Wang, Ming-Quan; Xiao, Yan-Bo; Gao, Ming

    2017-06-01

    Based on characteristics of high-tech industry in Northeast China, high-tech industry competitiveness index system was developed, and the competitiveness of high-tech industry was evaluated through principal component analysis and location quotient method. The results showed that the scale of high-tech industry in Northeast China as a whole was small, and presented a decreasing trend for the proportion in the country. The competitiveness of high-tech industry in Northeast China lagged far behind that of the eastern and central regions. The high-tech industry competitiveness of Liaoning, Jilin and Heilongjiang provinces in China ranked 15, 19 and 21, respectively. The manufacture of medicine in Jilin province, and the manufacture of aircraft and spacecraft and the related equipment in Liaoning and Heilongjiang provinces had high competitive advantage, but the manufacture of electronic equipment and communication equipment and the manufacture of computers and office equipment was lack of competitiveness. The development suggestions were put forward to improve the competitiveness of high-tech industries in Northeast China.

  7. Several Theoretical Issues on Agricultural Sci-tech Service and Management

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    In view of particularity and complexity of agricultural sci-tech service and management,this paper presents definition of basic concept of agricultural sci-tech service and management,sums up its basic characteristics,and discusses and analyzes its structural elements and functions. The agricultural sci-tech service and management plays an important role in speeding up rural construction and narrowing the gap between urban and rural areas. It ensures benign cycle of scientific and technological achievements and regional environment,and promotes development of agricultural industrialization.

  8. [The development of strategic management of high-tech surgical medical care].

    Science.gov (United States)

    Nechaev, V S; Krasnov, A V

    2013-01-01

    The high-tech surgical medical care is one of the most effective types of medical care in Russia. However high-tech surgical treatment very often is inaccessible for patients. The development of basics of strategic management of high-tech surgical care makes it possible to enhance availability of this type of care and to shorten the gap between volumes of rendered care and population needs. This approach can be resulted in decrease of disability and mortality of the most prevalent diseases of cardio-vascular diseases, malignant neoplasms, etc. The prerequisites can be developed to enhance life quality and increase longevity of population.

  9. The FinTech phenomenon: antecedents of financial innovation perceived by the popular press

    OpenAIRE

    Zavolokina, Liudmila; Dolata, Mateusz; Schwabe, Gerhard

    2016-01-01

    The financial industry has been strongly influenced by digitalization in the past few years reflected by the emergence of “FinTech,” which represents the marriage of “finance” and “information technology.” FinTech provides opportunities for the creation of new services and business models and poses challenges to traditional financial service providers. Therefore, FinTech has become a subject of debate among practitioners, investors, and researchers and is highly visible in the popular media. ...

  10. The People's Republic of China's high-tech exports: Myth and reality

    OpenAIRE

    Xing, Yuqing

    2012-01-01

    Trade statistics portray the People's Republic of China (PRC) as the largest exporter of high-tech products. In this paper I will argue that the PRC's leading position in high-tech exports is a myth created by outdated trade statistics which are inconsistent with trade based on global supply chains. Current trade statistics mistakenly credit entire values of assembled high-tech products to the PRC, thus greatly inflating its exports. In 2009, the PRC's value-added accounted for only about 3% ...

  11. China s Imp.& Exp.of New and High-tech Products

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Import of New and High-tech Products Increases Rapidly The proportion of new and high-tech products in the total import continues to increase.Ever since 1991,the proportion of new and high-tech products in the total import has experienced a continuous growth.It took up only 14.8% of the total import in 1991.The figure reached 20.8% in 1998,and further rose to that of 26.3% in 2001.From January to June this year,the import of new and hightech products totaled 34.540 billion USD,up 18.1% over the same per...

  12. Is there a large-country advantage in high-tech?

    OpenAIRE

    Jan Fagerberg

    1995-01-01

    High-tech is a commonly used catch-word for industries that use a relatively large share of their resources on R&D and develop many new products and processes. It is a widely held view that high- tech is good for growth, and that countries that succeed in high- tech industry perform well. Schumpeterian theory, as well as the more recent “new growth” theories, are often quoted in support of this view. However, the “new growth” theories also suggest that large countries are more likely than sma...

  13. Baza danych BazTech – integracja i poszerzanie dostępu

    OpenAIRE

    2014-01-01

    The BazTech database – integration and widening access. The BazTech base enables the access to scientific publications in Polish journals in the field of technical sciences, and as one of the resources of open science is available at the Virtual Library of Science. The paper presents the current state of BazTech as an introduction to the review of the development of the base in the direction of integration with other resources. Integration – apart from multibrowsers (eg PRIMO), data aggregato...

  14. The FinTech phenomenon: antecedents of financial innovation perceived by the popular press

    OpenAIRE

    Zavolokina, Liudmila; Dolata, Mateusz; Schwabe, Gerhard

    2016-01-01

    The financial industry has been strongly influenced by digitalization in the past few years reflected by the emergence of “FinTech,” which represents the marriage of “finance” and “information technology.” FinTech provides opportunities for the creation of new services and business models and poses challenges to traditional financial service providers. Therefore, FinTech has become a subject of debate among practitioners, investors, and researchers and is highly visible in the popular media. ...

  15. Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.

    Science.gov (United States)

    Clayton, Amy C; Bentz, Joel S; Wasserman, Patricia G; Schwartz, Mary R; Souers, Rhona J; Chmara, Beth Anne; Laucirica, Rodolfo; Clary, Karen M; Moriarty, Ann T

    2010-08-01

    Differences in participant responses for ThinPrep (TP) and non-ThinPrep (NTP) preparations for gastrointestinal cytology challenges, which circulated in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology (CAP NGC), may help to identify performance variations between preparation types. To compare the performance of TP-prepared slides of gastrointestinal exfoliative cytology specimens to that of NTP preparations in the CAP NGC program. Participant responses between 2000 and 2007 were evaluated for esophageal wash/brush, gastric wash/brush, and biliary tract brush specimens with a reference diagnosis of adenocarcinoma, squamous cell carcinoma, carcinoid, or spindle cell neoplasm. ThinPrep challenges were compared with NTP preparations (conventional smears, cytospins) for discordant responses. In all, 6023 pathologist responses and 3825 cytotechnologist responses were reviewed. Non-ThinPrep preparations comprised 93% (n = 11 588) of the challenges, while 7% (n = 912) were TP material. A match for a "positive/suspicious" diagnosis was seen in 88.5% of NTP and 95.9% of TP preparations (P cytology specimens circulated in an interlaboratory comparison program. Performance varied by reference interpretation, with the best performance for the interpretation of adenocarcinoma. Cytotechnologists and pathologists performed at the same level overall, but with differences for the diagnosis of spindle cell neoplasm and squamous carcinoma.

  16. Access to Basic HIV-Related Services and PrEP Acceptability among Men Who Have sex with Men Worldwide: Barriers, Facilitators, and Implications for Combination Prevention

    Directory of Open Access Journals (Sweden)

    George Ayala

    2013-01-01

    Full Text Available Introduction. Men who have sex with men (MSM are disproportionately impacted by HIV globally. Easily accessible combination HIV prevention strategies, tailored to the needs of MSM, are needed to effectively address the AIDS pandemic. Methods and Materials. We conducted a cross-sectional study among MSM (n=3748 from 145 countries from April to August 2012. Using multivariable random effects models, we examined factors associated with acceptability of preexposure prophylaxis (PrEP and access to condoms, lubricants, HIV testing, and HIV treatment. Results. Condoms and lubricants were accessible to 35% and 22% of all respondents, respectively. HIV testing was accessible to 35% of HIV-negative respondents. Forty-three percent of all HIV-positive respondents reported that antiretroviral therapy was easily accessible. Homophobia, outness, and service provider stigma were significantly associated with reduced access to services. Conversely, community engagement, connection to gay community, and comfort with service providers were associated with increased access. PrEP acceptability was associated with lower PrEP-related stigma, less knowledge about PrEP, less outness, higher service provider stigma, and having experienced violence for being MSM. Conclusions. Ensuring HIV service access among MSM will be critical in maximizing the potential effectiveness of combination approaches, especially given the interdependence of both basic and newer interventions like PrEP. Barriers and facilitators of HIV service access for MSM should be better understood and addressed.

  17. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  18. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  19. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  20. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

    Science.gov (United States)

    Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein; Kirschner, Benny; Rozemeijer, Kirsten; Bonde, Jesper; Rygaard, Carsten; Lynge, Elsebeth

    2015-01-01

    Background: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories. Methods: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity. Results: At 23–29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30–44 years, the increase with SurePath/FocalPoint was 58% the 16% increase with ThinPrep was not significant. At 45–59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23–29 years, but decreased by two-thirds at 45–59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen. Conclusions: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent. PMID:26448176

  1. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  2. The Effect of Metacognitive Strategy Training on Science Process Skills and Science Self Efficacy among First Year Prep Students with Learning Disabilities

    Science.gov (United States)

    Gomaa, Omema Mostafa Kamel

    2016-01-01

    This study investigated the effect of using metacognitive strategy training on science process skills and science self efficacy in learning disabled first year prep students. A total of 60 students identified with LD were invited to participate. The sample was randomly divided into two groups; experimental (n = 30 boys) and control (n = 30 boys ).…

  3. 25 CFR 1000.407 - Do the wage and labor standards in the Davis-Bacon Act apply to Tribes and Tribal Consortia?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Do the wage and labor standards in the Davis-Bacon Act....407 Do the wage and labor standards in the Davis-Bacon Act apply to Tribes and Tribal Consortia? No, wage and labor standards of the Davis-Bacon Act do not apply to employees of Tribes and...

  4. Gene-Age Interactions in Blood Pressure Regulation : A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia

    NARCIS (Netherlands)

    Simino, Jeannette; Shi, Gang; Bis, Joshua C; Chasman, Daniel I; Ehret, Georg B; Gu, Xiangjun; Guo, Xiuqing; Hwang, Shih-Jen; Sijbrands, Eric; Smith, Albert V; Verwoert, Germaine C; Bragg-Gresham, Jennifer L; Cadby, Gemma; Chen, Peng; Cheng, Ching-Yu; Corre, Tanguy; de Boer, Rudolf A; Goel, Anuj; Johnson, Toby; Khor, Chiea-Chuen; Lluís-Ganella, Carla; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Nolte, Ilja M; Sim, Xueling; Sõber, Siim; van der Most, Peter J; Verweij, Niek; Zhao, Jing Hua; Amin, Najaf; Boerwinkle, Eric; Bouchard, Claude; Dehghan, Abbas; Eiriksdottir, Gudny; Elosua, Roberto; Franco, Oscar H; Gieger, Christian; Harris, Tamara B; Hercberg, Serge; Hofman, Albert; James, Alan L; Johnson, Andrew D; Kähönen, Mika; Khaw, Kay-Tee; Kutalik, Zoltan; Larson, Martin G; Launer, Lenore J; Li, Guo; Liu, Jianjun; Liu, Kiang; Morrison, Alanna C; Navis, Gerjan; Ong, Rick Twee-Hee; Papanicolau, George J; Penninx, Brenda W; Psaty, Bruce M; Raffel, Leslie J; Raitakari, Olli T; Rice, Kenneth; Rivadeneira, Fernando; Rose, Lynda M; Sanna, Serena; Scott, Robert A; Siscovick, David S; Stolk, Ronald P; Uitterlinden, Andre G; Vaidya, Dhananjay; van der Klauw, Melanie M; Vasan, Ramachandran S; Vithana, Eranga Nishanthie; Völker, Uwe; Völzke, Henry; Watkins, Hugh; Young, Terri L; Aung, Tin; Bochud, Murielle; Farrall, Martin; Hartman, Catharina A; Laan, Maris; Lakatta, Edward G; Lehtimäki, Terho; Loos, Ruth J F; Lucas, Gavin; Meneton, Pierre; Palmer, Lyle J; Rettig, Rainer; Snieder, Harold; Tai, E Shyong; Teo, Yik-Ying; van der Harst, Pim; Wareham, Nicholas J; Wijmenga, Cisca; Wong, Tien Yin; Fornage, Myriam; Gudnason, Vilmundur; Levy, Daniel; Palmas, Walter; Ridker, Paul M; Rotter, Jerome I; van Duijn, Cornelia M; Witteman, Jacqueline C M; Chakravarti, Aravinda; Rao, Dabeeru C

    2014-01-01

    Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (

  5. Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia

    NARCIS (Netherlands)

    J. Simino (Jeannette); G. Shi (Gang); J.C. Bis (Joshua); D.I. Chasman (Daniel); G.B. Ehret (Georg); X. Gu (Xiangjun); X. Guo (Xiuqing); S.J. Hwang; E.J.G. Sijbrands (Eric); G.D. Smith; G.C. Verwoert (Germaine); J.L. Bragg-Gresham (Jennifer L.); G. Cadby (Gemma); P. Chen (Ping); C-Y. Cheng (Ching-Yu); T. Corre (Tanguy); R.A. de Boer (Rudolf); A. Goel (Anuj); T. Johnson (Toby); C.C. Khor; C. Lluís-Ganella (Carla); J. Luan; L.-P. Lyytikäinen (Leo-Pekka); I.M. Nolte (Ilja); X. Sim (Xueling); S. Sõber (Siim); P.J. van der Most (Peter); N. Verweij (Niek); J.H. Zhao (Jing); N. Amin (Najaf); E.A. Boerwinkle (Eric); C. Bouchard (Claude); A. Dehghan (Abbas); G. Eiriksdottir (Gudny); R. Elosua (Roberto); O.H. Franco (Oscar); C. Gieger (Christian); T.B. Harris (Tamara); S. Hercberg (Serge); A. Hofman (Albert); A.L. James (Alan); A.D. Johnson (Andrew); M. Kähönen (Mika); K-T. Khaw (Kay-Tee); Z. Kutalik (Zoltán); M.G. Larson (Martin); L.J. Launer (Lenore); G. Li (Guo); J. Liu (Jianjun); K. Liu (Kiang); A.C. Morrison (Alanna); G. Navis (Gerjan); R.T.H. Ong (Rick Twee-Hee); G.J. Papanicolau (George); B.W.J.H. Penninx (Brenda); B.M. Psaty (Bruce); L.J. Raffel (Leslie); O. Raitakari (Olli); K. Rice (Kenneth); F. Rivadeneira Ramirez (Fernando); L.M. Rose (Lynda); S. Sanna (Serena); R.A. Scott (Robert); D.S. Siscovick (David); R.P. Stolk (Ronald); A.G. Uitterlinden (André); D. Vaidya (Dhananjay); M.M. van der Klauw (Melanie); R.S. Vasan (Ramachandran Srini); E.N. Vithana (Eranga); U. Völker (Uwe); H. Völzke (Henry); H. Watkins (Hugh); T.L. Young (Terri); T. Aung (Tin); M. Bochud (Murielle); M. Farrall (Martin); C.A. Hartman (Catharina); M. Laan (Maris); E. Lakatta (Edward); T. Lehtimäki (Terho); R.J.F. Loos (Ruth); G. Lucas (Gavin); P. Meneton (Pierre); C. Palmer (Cameron); R. Rettig (Rainer); H. Snieder (Harold); E.S. Tai (Shyong); Y.-Y. Teo (Yik-Ying); P. van der Harst (Pim); N.J. Wareham (Nick); C. Wijmenga (Cisca); T.Y. Wong (Tien Yin); M. Fornage (Myriam); V. Gudnason (Vilmundur); D. Levy (Daniel); W. Palmas (Walter); P.M. Ridker (Paul); J.I. Rotter (Jerome); C.M. van Duijn (Cock); J.C.M. Witteman (Jacqueline); A. Chakravarti (Aravinda); D.C. Rao (Dabeeru C.)

    2014-01-01

    textabstractAlthough age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandar

  6. Probe into Constructing the Marketing System of Library Consortia%图书馆联盟营销体系建设探究

    Institute of Scientific and Technical Information of China (English)

    詹庆东

    2015-01-01

    The present condition of the information marketing of library consortia in China is investigated. According to the seven part of the marketing system-- marketing subject, marketing products, sales channels, sales price, sales promotion mechanism, marketing organization, marketing management departments, launches the research to the existing problems in marketing system of library consortia in China. Finally, the paper put forward the corresponding countermeasure, to improve the marketing system of library consortia, and promote the healthy, stable, sustainable development of library consortia.%调查我国主要的图书馆联盟信息营销现状,针对营销体系的七个组成部分——营销主体、营销产品、销售渠道、销售价格、促销机制、营销组织、营销管理职能部门,对我国图书馆联盟营销体系存在的问题展开研究,最后提出相应对策。

  7. Introduction of the Thin Prep Imaging System™ (TIS: Experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-01-01

    Full Text Available Objective: Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women′s Hospital. We introduced the TIS in December 2004. Methods: The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003-November 2004 are taken as the historic control group for our study. Results :The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022 . The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion :The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  8. Acceptability of an open-label wait-listed trial design: Experiences from the PROUD PrEP study

    Science.gov (United States)

    Brodnicki, Elizabeth; Desai, Monica; McCormack, Sheena; Nutland, Will; Wayal, Sonali; White, Ellen; Wood, Gemma; Barber, Tristan; Bell, Gill; Clarke, Amanda; Dolling, David; Dunn, David; Fox, Julie; Haddow, Lewis; Lacey, Charles; Nardone, Anthony; Quinn, Killian; Rae, Caroline; Reeves, Iain; Rayment, Michael; White, David; Apea, Vanessa; Ayap, Wilbert; Dewsnap, Claire; Collaco-Moraes, Yolanda; Schembri, Gabriel; Sowunmi, Yinka; Horne, Rob

    2017-01-01

    Background PROUD participants were randomly assigned to receive pre-exposure prophylaxis (PrEP) immediately or after a deferred period of one-year. We report on the acceptability of this open-label wait-listed trial design. Methods Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. We also conducted in-depth interviews (IDI) with a purposely selected sub-sample of participants. Results Acceptability questionnaires were completed by 76% (415/544) of participants. After controlling for age, immediate-group participants were almost twice as likely as deferred-group participants to complete the questionnaire (AOR:1.86;95%CI:1.24,2.81). In quantitative data, the majority of participants in both groups found the wait-listed design acceptable when measured by satisfaction of joining the study, intention to remain in the study, and interest in joining a subsequent study. However, three-quarters thought that the chance of being in the deferred-group might put other volunteers off joining the study. In free-text responses, data collection tools were the most frequently reported least liked aspect of the study. A fifth of deferred participants reported ‘being deferred’ as the thing they least liked about the study. However, more deferred participants disliked the data collection tools than the fact that they had to wait a year to access PrEP. Participants in the IDIs had a good understanding of the rationale for the open-label wait-listed study design. Most accepted the design but acknowledged they were, or would have been, disappointed to be randomised to the deferred group. Five of the 25 participants interviewed reported some objection to the wait-listed design. Conclusion The quantitative and qualitative findings suggest that in an environment where PrEP was not available, the rationale for the wait-listed trial design was well understood and

  9. Evaluation of the Illumina(®) Beta Version ForenSeq™ DNA Signature Prep Kit for use in genetic profiling.

    Science.gov (United States)

    Churchill, Jennifer D; Schmedes, Sarah E; King, Jonathan L; Budowle, Bruce

    2016-01-01

    While capillary electrophoresis-based technologies have been the mainstay for human identity typing applications, there are limitations with this methodology's resolution, scalability, and throughput. Massively parallel sequencing (MPS) offers the capability to multiplex multiple types of forensically-relevant markers and multiple samples together in one run all at an overall lower cost per nucleotide than traditional capillary electrophoresis-based methods; thus, addressing some of these limitations. MPS also is poised to expand forensic typing capabilities by providing new strategies for mixture deconvolution with the identification of intra-STR allele sequence variants and the potential to generate new types of investigative leads with an increase in the overall number and types of genetic markers being analyzed. The beta version of the Illumina ForenSeq DNA Signature Prep Kit is a MPS library preparation method with a streamlined workflow that allows for targeted amplification and sequencing of 63 STRs and 95 identity SNPs, with the option to include an additional 56 ancestry SNPs and 22 phenotypic SNPs depending on the primer mix chosen for amplification, on the MiSeq desktop sequencer (Illumina). This study was divided into a series of experiments that evaluated reliability, sensitivity of detection, mixture analysis, concordance, and the ability to analyze challenged samples. Genotype accuracy, depth of coverage, and allele balance were used as informative metrics for the quality of the data produced. The ForenSeq DNA Signature Prep Kit produced reliable, reproducible results and obtained full profiles with DNA input amounts of 1ng. Data were found to be concordant with current capillary electrophoresis methods, and mixtures at a 1:19 ratio were resolved accurately. Data from the challenged samples showed concordant results with current DNA typing methods with markers in common and minimal allele drop out from the large number of markers typed on these

  10. The effects of group size and group economic factors on collaboration: a study of the financial performance of rural hospitals in consortia.

    Science.gov (United States)

    Chan, B; Feldman, R; Manning, W G

    1999-04-01

    To determine factors that distinguish effective rural hospital consortia from ineffective ones in terms of their ability to improve members' financial performance. Two questions in particular were addressed: (1) Do large consortia have a greater collective impact on their members? (2) Does a consortium's economic environment determine the degree of collective impact on members? Based on the hospital survey conducted during February 1992 by the Robert Wood Johnson Hospital-Based Rural Health Care project of rural hospital consortia. The survey data were augmented with data from Medicare Cost Reports (1985-1991), AHA Annual Surveys (1985-1991), and other secondary data. Dependent variables were total operating profit, cost per adjusted admission, and revenue per adjusted admission. Control variables included degree of group formalization, degree of inequality of resources among members (group asymmetry), affiliation with other consortium group(s), individual economic environment, common hospital characteristics (bed size, ownership type, system affiliation, case mix, etc.), year (1985-1991), and census region dummies. All dependent variables have a curvilinear association with group size. The optimum group size is somewhere in the neighborhood of 45. This reveals the benefits of collective action (i.e., scale economies and/or synergy effects) and the issue of complexity as group size increases. Across analyses, no strong evidence exists of group economic environment impacts, and the environmental influences come mainly from the local economy rather than from the group economy. There may be some success stories of collaboration among hospitals in consortia, and consortium effects vary across different collaborations. When studying consortia, it makes sense to develop a typology of groups based on some performance indicators. The results of this study imply that government, rural communities, and consortium staff and steering committees should forge the consortium

  11. Tech-X发动机及其先进技术分析%Analysis on Tech-X Engine and Its Advance Technology

    Institute of Scientific and Technical Information of China (English)

    李杰; 巨亚斌

    2013-01-01

      Tech-X发动机是GE公司研发的用于超大航程公务机的新一代高涵道比涡扇发动机。本文就Tech-X发动机的性能指标和先进技术创新进行了概括性分析,供相关人士参考。%The Tech-X is a high bypass turbofan engine currently under development by GE Aviation. It is being developed in paral el with the larger CFM International LEAP-X, and includes many similar technologies, like blisks and NOx reducing combustors. GE sees potential in using the engine both on large cabin business jets and regional aircraft, where it wil replace the CF34 in GE's production line.

  12. Virginia Tech Corps of Cadets alumnus Timothy Dillera named Hokie Hero

    OpenAIRE

    Cox, Carrie

    2009-01-01

    Corps of Cadets alumnus Capt. Timothy Dillera, United States Air Force, who received a degree in chemistry from the College of Science in 2003 has been selected as the Hokie Hero for the Virginia Tech versus Boston College football game.

  13. Virginia Tech structural engineer part of a winning design team for unusual corporate headquarters

    OpenAIRE

    Steeves, Sue

    2010-01-01

    The American Institute of Steel Construction has presented a national award to a design team, including a Virginia Tech structural engineer, for its work on a dramatic cantilevered corporate headquarters building in Michigan.

  14. Virginia Tech part of $14 million National Science Foundation nanotechnology grant

    OpenAIRE

    Doss, Catherine

    2008-01-01

    Researchers from geosciences and civil and environmental engineering at Virginia Tech are part of a consortium of four principal universities and five other schools awarded a multi-million dollar grant to study nanotechnology and the environment.

  15. Hi-tech Researches Speed up Scientific and Technological Innovations of CNOOC

    Institute of Scientific and Technical Information of China (English)

    Dong Weiliang; Wang Weiyuan

    2007-01-01

    @@ The scientific and technological development of CNOOC Limited entered a new stage during the Tenth Five-Year Plan period. High-tech researches in the company have catalyzed the technological innovation of the offshore petroleum industry.

  16. FRIDAY: EPA Administrator Visiting Georgia Tech to Discuss Manufacturing Innovation and Environmental Sustainability

    Science.gov (United States)

    ATLANTA - On Friday, EPA Administrator Gina McCarthy will visit Georgia Tech to speak about the connection between manufacturing innovation and environmental sustainability. McCarthy will meet with more than 50 high school students and faculty parti

  17. Definition of a short-cut methodology for assessing earthquake-related Na-Tech risk.

    Science.gov (United States)

    Busini, Valentina; Marzo, Enrico; Callioni, Andrea; Rota, Renato

    2011-08-15

    Na-Tech (Natural and Technological) refers to industrial accidents triggered by natural events such as storms, earthquakes, flooding, and lightning. Herein, a qualitative methodology for the initial assessment of earthquake Na-Tech risk has been developed as a screening tool to identify which situations require a much more expensive Quantitative Risk Analysis (QRA). The proposed methodology, through suitable Key Hazard Indicators (KHIs), identifies the Na-Tech risk level associated with a given situation (i.e., a process plant located in a given territory), using the Analytical Hierarchy Process as a multi-criteria decision tool for the evaluation of such KHIs. The developed methodology was validated by comparing its computational results with QRA results that involved Na-Tech events previously presented in literature.

  18. Kalam's visit to cement Indo-Swiss ties in high tech area

    CERN Multimedia

    Sumir, Paul

    2005-01-01

    Seeking to boost Indo-Swiss cooperation in high tech areas, President APJ Abdul Kalam arrived in Geneva on a four-day visit to Switzerland aimed at firming up plans for future cooperation with the CERN

  19. Virginia Tech mourns the loss of Dr. Bernard "Bernie" F. Feldman

    OpenAIRE

    Owczarski, Mark

    2004-01-01

    Bernard "Bernie" F. Feldman of Check, Va., professor of biomedical sciences and pathobiology in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech , was killed in an automobile accident Feb. 19.

  20. The Trail Inventory of Bayou Teche National Wildlife Refuge [Cycle 1

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Bayou Teche National Wildlife Refuge. Trails in this inventory are...

  1. Violence-prevention summit at Virginia Tech tackles bullying, gender-based violence, more

    OpenAIRE

    2010-01-01

    Bullying in schools, aggression in the workplace, violence against women -- all are complex problems. On Nov. 12 and 13, Virginia Tech hosts a gathering to make recommendations about violence prevention.

  2. High-Tech Blood Sugar Monitors May Help People with Type 1 Diabetes

    Science.gov (United States)

    ... gov/news/fullstory_163211.html High-Tech Blood Sugar Monitors May Help People With Type 1 Diabetes ... need insulin shots every day manage their blood sugar levels safely, two new studies suggest. Also known ...

  3. Technology for Tomorrow---High-Tech Exhibition Held in HONG KONG

    Institute of Scientific and Technical Information of China (English)

    Fang Lin

    1997-01-01

    @@ "Technology for Tomorrow"--- High-Tech Exhibition has been held by Hong Kong Science & Technology Sector for Celebration of Return of Sovereignty Association and China Association Science & Technology on June 28 to July 4, 1997 in Hong Kong.

  4. Virginia Tech's Ashley White named to USA Today All-USA First Team

    OpenAIRE

    Crumbley, Liz

    2005-01-01

    Virginia Tech senior Ashley White, a University Honors student pursuing degrees in both materials science and engineering and music performance, has been named to USA Today's All-USA College Academic First Team.

  5. Virginia Tech team qualifies as DARPA Urban Challenge semi-finalist

    OpenAIRE

    Crumbley, Liz

    2007-01-01

    "VictorTango," a team of Virginia Tech engineering and geography students, will travel to Victorville, Calif., for the national qualifying rounds of the Urban Challenge autonomous vehicle competition, sponsored by the Defense Advanced Research Projects Agency (DARPA).

  6. FDA OKs High-Tech Diabetes Device to Help Replace Fingerstick Tests

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162638.html FDA OKs High-Tech Diabetes Device to Help Replace ... too low, and potentially incorrect insulin dosing, the FDA said. The Dexcom G5 is the first continuous ...

  7. Comparative Analysis of Capital Productivity in China's High-Tech Industries

    Institute of Scientific and Technical Information of China (English)

    LingWang; AdamSzirmai

    2005-01-01

    While labor productivity is a topic of constant debate and has been studied extensively, far less attention has been devoted to the question of capital productivity. Productive use of physical capital is an important source of economic growth and investment return. This paper presents a comparative study of capital productivity in China's high-tech industry. Using a version of the perpetual inventory method (PIM), new estimates have been made of the physical capital stock by sector. Capital productivity in China's high-tech industry is higher than in total manufacturing, but the gap between them has been shrinking. Comparison with high-tech industries in the US., highlights that China's high-tech industries could play a more important role in the growth of manufacturing and the whole economy.

  8. Maya Angelou to speak during Virginia Tech's third annual Martin Luther King Jr. celebration

    OpenAIRE

    Williams, Meghan

    2008-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  9. Maya Angelou to visit Virginia Tech during third annual Martin Luther King, Jr. celebration

    OpenAIRE

    Williams, Meghan

    2007-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  10. Biomedical Engineering Bionanosystems Research at Louisiana Tech University

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, James; Lvov, Yuri; Hegab, Hisham; Snow, Dale; Wilson, Chester; McDonald, John; Walker, Lynn; Pratt, Jon; Davis, Despina; Agarwal, Mangilal; DeCoster, Mark; Feng, June; Que, Long; O' Neal, Chad; Guilbeau, Eric; Zivanovic, Sandra; Dobbins, Tabbetha; Gold, Scott; Mainardi, Daniela; Gowda, Shathabish; Napper, Stan

    2010-03-25

    The nature of this project is to equip and support research in nanoengineered systems for biomedical, bioenvironmental, and bioenergy applications. Funds provided by the Department of Energy (DoE) under this Congressional Directive were used to support two ongoing research projects at Louisiana Tech University in biomedical, bioenvironmental, and bioenergy applications. Two major projects (Enzyme Immobilization for Large Scale Reactors to Reduce Cellulosic Ethanol Costs, and Nanocatalysts for Coal and Biomass Conversion to Diesel Fuel) and to fund three to five additional seed projects were funded using the project budget. The project funds also allowed the purchase and repair of sophisticated research equipment that will support continued research in these areas for many years to come. Project funds also supported faculty, graduate students, and undergraduate students, contributing to the development of a technically sophisticated work force in the region and the State. Descriptions of the technical accomplishments for each funded project are provided. Biofuels are an important part of the solution for sustainable transportation fuel and energy production for the future. Unfortunately, the country's appetite for fuel cannot be satisfied with traditional sugar crops such as sugar cane or corn. Emerging technologies are allowing cellulosic biomass (wood, grass, stalks, etc.) to also be converted into ethanol. Cellulosic ethanol does not compete with food production and it has the potential to decrease greenhouse gas (GHG) emissions by 86% versus current fossil fuels (current techniques for corn ethanol only reduce greenhouse gases by 19%). Because of these advantages, the federal government has made cellulosic ethanol a high priority. The Energy Independence and Security Act of 2007 (EISA) requires a minimum production of at least 16 billion gallons of cellulosic ethanol by 2022. Indeed, the Obama administration has signaled an ambitious commitment of achieving

  11. The difficult business model for mask equipment makers and mask infrastructure development support from consortia and governments

    Science.gov (United States)

    Hector, Scott

    2005-11-01

    The extension of optical projection lithography through immersion to patterning features with half pitch cash flow models to predict the affordable R&D while maintaining industry accepted internal rates of return. The results have been compared to estimates of the total R&D cost to bring a new generation of mask equipment to market for various types of tools. The analysis revealed that affordability of the required R&D is a significant problem for many suppliers of mask-making equipment. Consortia such as SEMATECH and Selete have played an important role in cost sharing selected mask equipment and material development projects. Governments in the United States, in Europe and in Japan have also helped equipment suppliers with support for R&D. This paper summarizes the challenging business model for mask equipment suppliers and highlight government support for mask equipment and materials development.

  12. Biological nitrogen fixation and biomass accumulation within poplar clones as a result of inoculations with diazotrophic endophyte consortia.

    Science.gov (United States)

    Knoth, Jenny L; Kim, Soo-Hyung; Ettl, Gregory J; Doty, Sharon L

    2014-01-01

    Sustainable production of biomass for bioenergy relies on low-input crop production. Inoculation of bioenergy crops with plant growth-promoting endophytes has the potential to reduce fertilizer inputs through the enhancement of biological nitrogen fixation (BNF). Endophytes isolated from native poplar growing in nutrient-poor conditions were selected for a series of glasshouse and field trials designed to test the overall hypothesis that naturally occurring diazotrophic endophytes impart growth promotion of the host plants. Endophyte inoculations contributed to increased biomass over uninoculated control plants. This growth promotion was more pronounced with multi-strain consortia than with single-strain inocula. Biological nitrogen fixation was estimated through (15)N isotope dilution to be 65% nitrogen derived from air (Ndfa). Phenotypic plasticity in biomass allocation and branch production observed as a result of endophyte inoculations may be useful in bioenergy crop breeding and engineering programs.

  13. "Innovation and Intellectual Property Policies in European Research Infrastructure Consortia - PART I: The Case of the European Spallation Source ERIC"

    DEFF Research Database (Denmark)

    Yu, Helen; Wested, Jakob; Minssen, Timo

    2017-01-01

    of the problems society is facing today. To facilitate the creation and operation of such RIs, the EU adopted legal frameworks for European Research Infrastructure Consortia (ERIC). On August 31, 2015, the European Spallation Source (ESS) was established as an ERIC. Under the ERIC Regulations and ESS Statutes......Research and innovation are key pillars of the EU’s strategy to create sustainable growth and prosperity in Europe. Research infrastructures (RIs) are central instruments to implement this strategy. They bring together a wide diversity of expertise and interests to look for solutions to many......, the European Spallation Source ERIC is required to adopt various policy documents relating to the operation and management of the facility. These cover a wide variety of issues such as user access, public procurement, intellectual property rights (IPR), data management, and dissemination. One of the main goals...

  14. U.S. Army flyover hosted by the Virginia Tech Corps of Cadets Friday and Saturday

    OpenAIRE

    2008-01-01

    The Virginia Tech Corps of Cadets and the Army ROTC Department will sponsor, barring weather or operational factors, a military aircraft flyover with two AH-64 Apache attack helicopters from the Combat Aviation Brigade of the 82nd Airborne Division from Fort Bragg, N.C., during pre-game ceremonies of the Virginia Tech vs. Western Kentucky University football game to be held Saturday, Oct. 4.

  15. Definition of a shortcut methodology for assessing flood-related Na-Tech risk

    OpenAIRE

    Marzo, E.; Busini, V.; Rota, R.

    2012-01-01

    In this paper a qualitative methodology for the initial assessment of flood-related Na-Tech risk was developed as a screening tool to identify which situations require a much more expensive quantitative risk analysis (QRA). Through the definition of some suitable key hazard indicators (KHIs), the proposed methodology allows the identification of the Na-Tech risk level associated with a given situation; the analytical hierarchy process (AHP) was used as a multi-criteria decis...

  16. Sieciowe usługi informacyjne dla nauk technicznych : BazTech, BazTOL

    OpenAIRE

    2007-01-01

    The paper presents the current state and plans for development of the BazTech "Polish Technical Journals Contents" database. It is created by 22 academic libraries and centers for scientific information. The project is coordinated by the Cracow University of Technology. The Baz Tech database, situated at http://baztech.icm.edu.pl (ICM UW server), within the framework of the project "Virtual Scientific Library" lists over 400 journals. The paper also describes the assumptions for the creation ...

  17. Problems and Countermeasures of Zhejiang High-Tech Enterprises Industry-University-Institute Cooperation in China

    Science.gov (United States)

    Zhou, Qing; Mao, Chong-Feng; Hou, Lin

    Industry-university-institute cooperation is an important means to accelerate technical development and achievements for high-tech enterprises. Considering that Zhejiang high-tech enterprises existed some problems which included low cooperative level, single distribution, weak secondary R&D ability, obvious risk and so on, government should play an guiding role on improving information service system, enhancing cooperative level, promoting scientific intermediary service organization system construction, and building better environment for Industry-university-institute cooperation.

  18. HI-TECH BUSINESS IN ECONOMICALLY DEVELOPED COUNTRIES AND ITS INTEGRATION MECHANISM

    Directory of Open Access Journals (Sweden)

    V. N. Voronina

    2011-01-01

    Full Text Available In the hi-tech sphere, business integration forms widely wary. Particularly interesting is a way of such integration practiced in Japan through associations called «keiretsu» whose functioning mechanism is considered in detail. Specific features of this approach make it advantageous incomparison to classic western firm integration ways. Still, experiences gained in USA and some European countries, particularly in Finland, are of interest for Russian hi-tech business too.

  19. The Green Berry Consortia of the Sippewissett Salt Marsh: Millimeter-Sized Aggregates of Diazotrophic Unicellular Cyanobacteria

    Directory of Open Access Journals (Sweden)

    Elizabeth G. Wilbanks

    2017-09-01

    Full Text Available Microbial interactions driving key biogeochemical fluxes often occur within multispecies consortia that form spatially heterogeneous microenvironments. Here, we describe the “green berry” consortia of the Sippewissett salt marsh (Falmouth, MA, United States: millimeter-sized aggregates dominated by an uncultured, diazotrophic unicellular cyanobacterium of the order Chroococcales (termed GB-CYN1. We show that GB-CYN1 is closely related to Crocosphaera watsonii (UCYN-B and “Candidatus Atelocyanobacterium thalassa” (UCYN-A, two groups of unicellular diazotrophic cyanobacteria that play an important role in marine primary production. Other green berry consortium members include pennate diatoms and putative heterotrophic bacteria from the Alphaproteobacteria and Bacteroidetes. Tight coupling was observed between photosynthetic oxygen production and heterotrophic respiration. When illuminated, the green berries became supersaturated with oxygen. From the metagenome, we observed that GB-CYN1 encodes photosystem II genes and thus has the metabolic potential for oxygen production unlike UCYN-A. In darkness, respiratory activity rapidly depleted oxygen creating anoxia within the aggregates. Metagenomic data revealed a suite of nitrogen fixation genes encoded by GB-CYN1, and nitrogenase activity was confirmed at the whole-aggregate level by acetylene reduction assays. Metagenome reads homologous to marker genes for denitrification were observed and suggest that heterotrophic denitrifiers might co-occur in the green berries, although the physiology and activity of facultative anaerobes in these aggregates remains uncharacterized. Nitrogen fixation in the surface ocean was long thought to be driven by filamentous cyanobacterial aggregates, though recent work has demonstrated the importance of unicellular diazotrophic cyanobacteria (UCYN from the order Chroococcales. The green berries serve as a useful contrast to studies of open ocean UCYN and may

  20. K2 Warm Jupiters with the LCOGT TECH collaboration

    Science.gov (United States)

    Shporer, Avi; Bayliss, Daniel; Cochran, William D.; Colón, Knicole D.; Dragomir, Diana; Palle, Enric; Potter, Stephen; Siverd, Robert; LCOGT TECH Collaboration

    2016-06-01

    Many transiting gas giant planets on short orbital periods (so called hot Jupiters) have larger radii than theoretically expected. Although several explanations have been proposed, none have completely solved this puzzle. As the number of known transiting planets grew a correlation was identified between gas giant radius and the stellar incident flux. Still, it is not clear whether this correlation is causation. Several questions remain and answering them will characterize in more detail this observed correlation and in turn the process responsible for the inflated radii, such as: Is the lack of inflated warm Jupiters a robust feature? What is the incident flux below which there are no inflated gas giants? How low in incident flux does this correlation stretch? These questions arise since there are only a small number of transiting gas giants with low incident flux, below about 108 erg/s/cm2, corresponding to orbital periods of about 10 days and longer for a Sun-like host star. Discovering and confirming more transiting warm Jupiters is the goal of this project, undertaken by the LCOGT Transiting Exoplanet CHaracterization (TECH) team. We are using K2 as our main source of transiting warm Jupiter candidates, with a few candidates discovered in each K2 campaign. LCOGT telescopes are being used for obtaining additional ground-based transit light curves, which are critical for confirming and refining the K2 transit ephemeris as outliers during ingress or egress of the few transit events observed by K2 can bias the measured ephemeris. Further ground-based follow-up data, including spectroscopy, radial velocities, and high angular resolution imaging, are obtained by facilities directly accessible by LCOGT TECH team members. In addition, once LCOGT’s Network of Robotic Echelle Spectrographs (NRES) are deployed in the near future they will allow obtaining spectroscopy and radial velocities with LCOGT facilities. On top of studying the inflated hot Jupiter conundrum