PennDOT : fact book

Science.gov (United States)

2008-06-01

PennDOT was created in 1970 when the former : Department of Highways was merged with transportation related : functions from the Departments of Revenue, : Commerce, Community Affairs and Military Affairs. With : an annual budget of about $5.4 billion...

68Ga-autoclabeling of DOTA-TATE and DOTA-NOC

DEFF Research Database (Denmark)

Blom, Elisabeth; Koziorowski, Jacek

2012-01-01

A new method combining (68)Ga-labeling and steam sterilization, here called autoclabeling, has been evaluated for two somatostatin receptor binding tracers used for positron emission tomography (PET) imaging of neuroendocrine tumors; DOTA-TATE and -NOC....

Overview of Development and Formulation of ¹⁷⁷Lu-DOTA-TATE for PRRT.

Science.gov (United States)

Breeman, Wouter A P; Chan, Ho Sze; de Zanger, Rory M S; Konijnenberg, Mark K; de Blois, Erik

2016-01-01

Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs has become an established procedure for the treatment of patients suffering from inoperable neuroendocrine cancers over-expressing somatostatin receptors. Success of PRRT depends on the availability of the radiolabeled peptide with adequately high specific activity, so that required therapeutic efficacy can be achieved without saturating the limited number of receptors available on the target lesions. Specific activity of the radionuclide and the radiolabeled somatostatin analog are therefore an important parameters. Although these analogs have been investigated and improved, and successfully applied for PRRT for more than 15 years, there are still many possibilities for further improvements that fully exploit PRRT with 177Lu-DOTA-TATE. The here summarized data presented herein on increased knowledge of the components of 177Lu-DOTA-TATE (especially the purity of 177Lu and specific activity of 177Lu) and the reaction kinetics during labeling 177Lu-DOTA-TATE clearly show that the peptide dose and dose in GBq can be varied. Here we present an overview of the development, formulation and optimisation of 177Lu-DOTA-TATE, mainly addressing radiochemical parameters.

After the Prestige: A Postmodern Analysis of Penn and Teller

Directory of Open Access Journals (Sweden)

Miller, Liz

2015-12-01

Full Text Available By mocking the magic community and revealing the secret behind some of their tricks, Penn and Teller perform a kind of parodic and post-modern “anti-magic.” Penn and Teller display an artful use of rhetoric; in exposing the secrets and shortcomings of conjuring, they are revolutionizing the way people think about both the art of magic and the magic community. Individuals such as Penn and Teller may use parody to subvert the hegemonic interpretations. However, we also know that it is difficult to bring down a system while operating within that system. Thus, this article explores the way Penn and Teller are challenging the metanarrative of the magic community, using several of the duo’s more popular illusions as examples for analysis. Ultimately, this paper should help us gain a better understanding of the way parody can be used to challenge hegemonic conceptions, and the limitations of this type of rhetorical approach.

Collected works of John Tate part I (1951--1975)

CERN Document Server

Tate, John; Serre, Jean-Pierre

2016-01-01

In these volumes, a reader will find all of John Tate's published mathematical papers-spanning more than six decades-enriched by new comments made by the author. Included also is a selection of his letters. His letters give us a close view of how he works and of his ideas in process of formation.

Collected works of John Tate part II (1976--2006)

CERN Document Server

Tate, John; Serre, Jean-Pierre

2016-01-01

In these volumes, a reader will find all of John Tate's published mathematical papers-spanning more than six decades-enriched by new comments made by the author. Included also is a selection of his letters. His letters give us a close view of how he works and of his ideas in process of formation.

PENN neurodegenerative disease research - in the spirit of Benjamin Franklin.

Science.gov (United States)

Trojanowski, John Q

2008-01-01

Benjamin Franklin (1706-1790) was entrepreneur, statesman, supporter of the public good as well as inventor, and his most significant invention was the University of Pennsylvania (PENN). Franklin outlined his plans for a college providing practical and classical instruction to prepare youth for real-world pursuits in his 'Proposals Relating to the Education of Youth in Pensilvania' (1749), and Franklin's spirit of learning to serve society guides PENN to the present day. This is evidenced by the series of articles in this special issue of Neurosignals, describing research conducted by seasoned and newly recruited PENN faculty, addressing consequences of the longevity revolution which defines our epoch at the dawn of this millennium. While aging affects all organ systems, the nervous system is most critical to successful aging. Thus, the articles in this special issue of Neurosignals focus on research at PENN that is designed to prevent or ameliorate aging-related neurodegenerative disorders such as Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis and frontotemporal dementia. This research could enhance our chances of aging successfully in the continuing longevity revolution, and the essay here provides context and background on this research.

The added value of 68Ga-DOTA-TATE-PET to contrast-enhanced CT for primary site detection in CUP of neuroendocrine origin.

Science.gov (United States)

Kazmierczak, Philipp M; Rominger, Axel; Wenter, Vera; Spitzweg, Christine; Auernhammer, Christoph; Angele, Martin K; Rist, Carsten; Cyran, Clemens C

2017-04-01

To quantify the additional value of 68 Ga-DOTA-TATE PET/CT in comparison with contrast-enhanced CT alone for primary tumour detection in neuroendocrine cancer of unknown primary (CUP-NET). In total, 38 consecutive patients (27 men, 11 women; mean age 62 years) with histologically proven CUP-NET who underwent a contrast-enhanced 68 Ga-DOTA-TATE PET/CT scan for primary tumour detection and staging between 2010 and 2014 were included in this IRB-approved retrospective study. Two blinded readers independently analysed the contrast-enhanced CT and 68 Ga-DOTA-TATE PET datasets separately and noted from which modality they suspected a primary tumour. Consensus was reached if the results were divergent. Postoperative histopathology (24 patients) and follow-up 68 Ga-DOTA-TATE PET/CT imaging (14 patients) served as the reference standards and statistical measures of diagnostic accuracy were calculated accordingly. The majority of confirmed primary tumours were located in the abdomen (ileum in 19 patients, pancreas in 12, lung in 2, small pelvis in 1). High interobserver agreement was noted regarding the suspected primary tumour site (Cohen's k 0.90, p DOTA-TATE PET demonstrated a significantly higher sensitivity (94 % vs. 63 %, p = 0.005) and a significantly higher accuracy (87 % vs. 68 %, p = 0.003) than contrast-enhanced CT. Ga-DOTA-TATE PET/CT compared with contrast-enhanced CT alone provides an improvement in sensitivity of 50 % and an improvement in accuracy of 30 % in primary tumour detection in CUP-NET. • 68 Ga-DOTA-TATE PET augments the sensitivity of contrast-enhanced CT by 50 % • 68 Ga-DOTA-TATE PET augments the accuracy of contrast-enhanced CT by 30 % • Somatostatin receptor-targeted hybrid imaging optimizes primary tumour detection in CUP-NET.

PET/CT With 68Ga-DOTA-TATE for Diagnosis of Neuroendocrine: Differentiation in Patients With Castrate-Resistant Prostate Cancer.

Science.gov (United States)

Gofrit, Ofer Nathan; Frank, Stephen; Meirovitz, Amichay; Nechushtan, Hovav; Orevi, Marina

2017-01-01

Castrate-resistant prostate cancer (CRPC) often shows histological evidence of neuroendocrine differentiation (NED). To evaluate the extent of NED in patients with CRPC, we used PET/CT with Ga-[DOTA-Tyr]-octreotate (Ga-DOTA-TATE), a somatostatin analog that binds somatostatin receptor 2 with high affinity. This radiotracer is used in imaging of neuroendocrine tumors. Twelve patients (mean age, 65 [SD, 12] years) with CRPC were studied. Their mean prostate-specific antigen level at scanning was 85.6 (SD, 144.6) ng/mL. PET/CT images were obtained after the injection of 120 to 200 MBq of Ga-DOTA-TATE. All participants had at least 1 blastic metastasis demonstrating uptake of Ga-DOTA-TATE (mean SUVmax of 5.3 [SD, 2.3]). In 6 patients, moderately high to high uptakes (SUVmax, >5) were seen. Patients with multiple bone metastases had a significantly higher SUVmax compared with patients with few metastases (mean of 5.8 vs 3.8, P = 0.05). In 4 patients, lytic bone lesions or lymph node metastases also showed uptake of the tracer (mean SUVmax of 7.2 [SD, 3.2]). Uptake of the radiotracer was also observed in bones showing normal architecture in CT, suggesting that NED cells appear early during metastases development. Uptake of Ga-DOTA-TATE is a common finding in metastases of CRPC patients, suggesting that NED is frequent in these patients. In half of the patients, widespread uptake of Ga-DOTA-TATE was observed. This suggests that the possibility of treating selected CRCP patients with anti-neuroendocrine tumor therapies should be explored and that Ga-DOTA-TATE scanning could have a role in predicting the efficacy of these treatments.

Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors: First comparative results using the somatostatin analogues Lu-177 DOTA-NOC and Lu-177 DOTA-TATE

International Nuclear Information System (INIS)

Wehrmann, C.; Senftleben, S.; Baum, R.P.

2005-01-01

Peptide receptor radionuclide therapy (PRRT) is used in our department since 5 years (approx. 400 applications) for the treatment of patients with metastatic neuroendocrine tumors. Of all known peptides, the somatostatin analogue DOTA-NOC shows in vitro the highest affinity to somatostatin receptors (sstr) 3 and 5 and a very high affinity to sstr 2. We studied the in vivo behaviour of the two peptides DOTA-NOC and DOTA-TATE (highest affinity to sstr 2) by the use of different parameters like tumor and organ uptake, effective half-lifes (kinetics) and mean absorbed organ and tumor doses. We studied 27 patients with metastatic neuroendocrine tumors with high somatostatin expression, as verified prior to treatment by Ga-68 DOTA-NOC receptor PET/CT or somatostatin receptor scintigraphy (Tc-99m EDDA-Hynic TOC or In-111 OctreoScan, planar and SPECT). 22 patients (8M and 14F; aged 619 years) were treated with 2500 6790 MBq Lu-177 DOTA-TATE. Another 5 patients (1M and 4F, aged 6310 years) were treated with 4000 7400 MBq Lu-177 DOTA-NOC. Labelling efficiency and radiochemical purity using Lutetium-177 chloride (obtained from PerkinElmer Life Sciences, USA) were constantly over 99.5%. Whole-body scans (anterior/posterior) were performed at 0.5h, 3h, 24h, 48h, 72h and 96h p.i. ROIs were drawn over the whole-body, organs, and different metastases (mainly in the liver). Blood samples were obtained in 12 patients after therapy with Lu-177 DOTA-TATE over 5 days for calculating the kinetics in blood. The ROI results were used to determine the uptake and effective half-life in different organs (kidney, spleen, liver, bone etc.) and the tumor residence times. By means of geometric mean, and after background correction, the ROI results were also used to calculate the estimated absorbed organ and tumor doses using the OLINDA software. Compared to Lu-177 DOTA-TATE (=100%), the uptake of Lu-177 DOTA-NOC was higher for the whole-body (45%) and for normal tissues (28%), and also in the

Targeted radiotherapy with 177 Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

International Nuclear Information System (INIS)

Rodriguez C, J.; Murphy, C.A. de; Pedraza L, M.; Ferro F, G.; Murphy S, E.

2006-01-01

Malignant pancreas tumours induced in athymic mice are a good model for peptide receptor targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses after administration of 177 Lu-DOTA-TATE in mice as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells expressing somatostatin receptors, were implanted in athymic mice (n=18) to obtain the 177 Lu-DOTA-TATE biokinetics and dosimetry. To estimate its therapeutic efficacy 87 MBq were injected in a tail vein of 3 mice and 19 days p.i. there were a partial relapse. There was an epithelial and sarcoma mixed tumour in the kidneys of mouse III. The absorbed dose to tumour, kidney and pancreas was 50.5 ± 7.2 Gy, 17.5 ± 2.5 Gy and 12.6 ± 2.3 Gy respectively. These studies justify further therapeutic and dosimetry estimations to ensure that 177 Lu-DOTA-TATE will act as expected in man considering its kidney radiotoxicity. (Author)

Intraindividual comparison of 68Ga-DOTA-TATE and 18F-DOPA PET in patients with well-differentiated metastatic neuroendocrine tumours

International Nuclear Information System (INIS)

Haug, Alexander; Auernhammer, Christoph J.; Goeke, Burkhard; Waengler, Bjoern; Tiling, Reinhold; Bartenstein, Peter; Poepperl, Gabriele; Schmidt, Gerwin

2009-01-01

To compare the diagnostic impact of 68 Ga-DOTA-TATE and 18 F-DOPA PET in the diagnosis of well-differentiated metastatic neuroendocrine tumours (NET). PET/CT using both 68 Ga-DOTA-TATE and 18 F-DOPA was performed in 25 patients with histologically proven metastatic NET (nine gut, five pancreas, six lung, one paranasal sinus, four with unknown primary). Analyses of PET examinations were patient-based (pathological uptake: yes/no), and based on tumour regions (primary tumour if present and metastases of liver, lung, bones and lymph nodes). The results were compared with the results of contrast enhanced CT, and with plasma serotonin levels, which were available in 24 of the 25 patients. Patient-based sensitivities were 96% for 68 Ga-DOTA-TATE PET and 56% for 18 F-DOPA PET. 68 Ga-DOTA-TATE PET delineated metastases in 54 of 55 positive metastatic tumour regions in contrast to 29 of 55 delineated by 18 F-DOPA PET. Overall, 68 Ga-DOTA-TATE was superior to 18 F-DOPA in 13 patients (two patients showed fewer positive tumour regions with 18 F-DOPA PET). The results were comparable in 12 patients. In 13 of 24 patients, plasma serotonin levels were elevated, and 11 of these 13 patients showed pathological uptake of 18 F-DOPA. Of the 11 patients with normal levels of serotonin, 3 also showed positive 18 F-DOPA uptake. In patients positive for 18 F-DOPA uptake the maximum tumour SUVs were correlated with the levels of serotonin (r=0.66, p=0.01). In this study 68 Ga-DOTA-TATE PET proved clearly superior to 18 F-DOPA PET for detection and staging of NET. 18 F-DOPA uptake tended to be increased in those patients with elevated plasma serotonin. We conclude that 18 F-DOPA PET should be employed in patients with NET with negative 68 Ga-DOTA-TATE PET and elevated plasma serotonin. (orig.)

Obituary: Robert H. Koch (1929-2010)

Science.gov (United States)

Koch, Joanne; Corcoran, Michael; Holenstein, Bruce; Sion, Edward

2011-12-01

Robert H. Koch, emeritus professor of astronomy and astrophysics at the University of Pennsylvania, passed away at his home in Ardmore, Pennsylvania on 11 October 2010 after a brief illness. Bob was 80 years old and remained sharp and intellectually engaged with the astronomical community up until the onset of complications from a brain tumor. Bob was born in York, Pennsylvania on 19 December 1929, and graduated from York Catholic High School in 1947. He attended the University of Pennsylvania on a senatorial scholarship, graduating in 1951. After two years in the United States Army, he enrolled in graduate school at the University of Pennsylvania, doing his doctoral research on the photoelectric photometry of R CMa, AO Cas, AS Eri, and XY Leo at the Steward Observatory, University of Arizona in Tucson. Bob would continue this exploration of close binary stars, their atmospheres and interactions, for the rest of his career. Bob met his future spouse, Joanne C. Underwood, while in graduate school in 1957 and they were married in 1959. Bob received his PhD in astronomy in 1959 and moved to Amherst, Massachusetts, where he taught as a member of the Four College Astronomy Department until 1966. Following a year at the University of New Mexico in Albuquerque, Bob joined the Astronomy Department at Penn, teaching and doing research there until his retirement in 1996. Bob's main interests were the study of close and eclipsing binary stars, stellar envelopes and winds, intrinsic variables, transits and occultations, and the Milky Way Galaxy, producing well over 100 refereed publications. Bob was partial to photoelectric photometry and polarimetry, conducting most of his observational research at the University of Pennsylvania Flower and Cook Observatory, and at other ground- and space-based observatories. As an international figure in the area of binary stars, Bob had widespread collaborations with scientists at other institutions, in the US and throughout the world, and

Evaluation and comparison of Ga-68 DOTA-TATE and Ga-68 DOTA-NOC PET/CT imaging in well-differentiated thyroid cancer.

Science.gov (United States)

Ocak, Meltem; Demirci, Emre; Kabasakal, Levent; Aygun, Aslan; Tutar, Rumeysa O; Araman, Ahmet; Kanmaz, Bedii

2013-11-01

Somatostatin receptor (Sstr) scintigraphy with radiolabelled somatostatin analogues has been used extensively for the diagnosis and therapy of Sstr-expressing tumours. It has been shown that well-differentiated thyroid cancer (WDTC) cells have a high expression of Sstr2, Sstr3 and Sstr5. Hence, WDTC cells could be an ideal target for the evaluation of lesion uptake of Ga-68 DOTA-1-NaI3-octreotide (DOTA-NOC), which has a high affinity not only to Sstr2 but also to Sstr3 and Sstr5. The aim of the present study was to evaluate the value of Ga-68 DOTA-NOC as a target for Sstr2-expressing, Sstr3-expressing and Sstr5-expressing tumours in WDTC patients and to compare the results with those of Ga-68 DOTA-TATE in the same patient population. Thirteen patients with WDTC were included in our study: nine with papillary thyroid cancer, three with Hurthle cell carcinoma and one with follicular thyroid carcinoma. All patients had elevated serum thyroglobulin levels and negative post-therapeutic I-131 whole-body scans, which were obtained after the last radioiodine treatment. All patients had undergone two consecutive PET imaging studies with Ga-68 DOTA-D-Phe1-Tyr3-octreotate (DOTA-TATE) and Ga-68 DOTA-NOC, respectively. All images were evaluated visually, and maximum standardized uptake values were calculated. Both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC PET images gave comparable results. Among the 13 patients, imaging with both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC gave negative results in five (38%) patients and positive results in eight (62%) patients. A total of 45 lesions were identified on Ga-68 DOTA-TATE images and 42 on Ga-68 DOTA-NOC images; three lesions were missed. Lesion uptake was significantly higher on Ga-68 DOTA-TATE images. Maximum standardized uptake values of Ga-68 DOTA-TATE and Ga-68 DOTA-NOC were 12.9±9.1 and 6.3±4.1 (n=54, PDOTA-TATE has a higher lesion uptake even in WDTC patients and may have potential advantage over Ga-68 DOTA-NOC.

[Treatment of Gastroenteropancreatic Neuroendocrine Tumors with 177Lu-DOTA-TATE: Experience of the Portuguese Institute of Oncology in Porto].

Science.gov (United States)

Sampaio, Inês Lucena; Luiz, Henrique Vara; Violante, Liliana Sobral; Santos, Ana Paula; Antunes, Luís; Torres, Isabel; Sanches, Cristina; Azevedo, Isabel; Duarte, Hugo

2016-11-01

The purpose of this article is to report the experience of the Portuguese Institute of Oncology - Porto in the treatment of gastroenteropancreatic neuroendocrine tumors with 177Lu-DOTA-TATE, regarding the safety and efficacy of this treatment modality. A retrospective analysis of clinical reports of patients with gastroenteropancreatic neuroendocrine tumors undergoing treatment with 177Lu-DOTA-TATE between April 2011 and November 2013 was performed. Thirty six cases were reviewed and 30 completed all 3 cycles of 177Lu-DOTA-TATE (83.3%). In these patients it was registered: acute side effects in 8.9% of cycles; grade 3 CTCAE liver toxicity in 13.3% of patients (all with previous abnormal liver function); absence of significant renal or hematologic toxicity; symptomatic improvement in 71.4% of patients; median overall time to progression of 25.6 months; median overall survival from diagnosis of 121.7 months. Patients with higher expression of somatostatin receptors had longer progression-free survival and overall survival times (p DOTA-TATE is an effective, safe and well-tolerated treatment, as evidenced in our study by the following findings: symptomatic improvement in most patients and increased time to disease progression and survival (especially in those with higher sstr expression), with acute and significant subacute/chronic side effects reported only in a minority of cases. Peptide receptor radionuclide therapy with 177Lu-DOTA-TATE is a promising treatment for patients with gastroenteropancreatic neuroendocrine tumors, with demonstrated benefits in terms of safety and efficacy.

Penn State advanced light water reactor concept

International Nuclear Information System (INIS)

Borkowski, J.A.; Smith, K.A.; Edwards, R.M.; Robinson, G.E.; Schultz, M.A.; Klevans, E.H.

1987-01-01

The accident at Three Mile Island heightened concerns over the safety of nuclear power. In response to these concerns, a research group at the Pennsylvania State University (Penn State) undertook the conceptual design of an advanced light water reactor (ALWR) under sponsorship of the US Dept. of Energy (DOE). The design builds on the literally hundreds of years worth of experience with light water reactor technology. The concept is a reconfigured pressurized water reactor (PWR) with the capability of being shut down to a safe condition simply by removing all ac power, both off-site and on-site. Using additional passively activated heat sinks and replacing the pressurizer with a pressurizing pump system, the concept essentially eliminates the concerns of core damage associated with a total station blackout. Evaluation of the Penn State ALWR concept has been conducted using the EPRI Modular Modeling System (MMS). Results show that a superior response to normal operating transients can be achieved in comparison to the response with a conventional PWR pressurizer. The DOE-sponsored Penn State ALWR concept has evolved into a significant reconfiguration of a PWR leading to enhanced safety characteristics. The reconfiguration has touched a number of areas in overall plant design including a shutdown turbine in the secondary system, additional passively activated heat sinks, a unique primary side pressurizing concept, a low pressure cleanup system, reactor building layout, and a low power density core design

Recycling at Penn State's Beaver Stadium. "Recycle on the Go" Success Story

Science.gov (United States)

US Environmental Protection Agency, 2009

2009-01-01

With a 13-year-old recycling program, The Pennsylvania State University's (Penn State) Beaver Stadium in the past diverted nearly 30 tons of recyclables per year from local landfills. A new initiative to promote recycling in the stadium's tailgating area has helped Penn State more than triple its old recycling record, collecting 112 tons in 2008.…

Targeted radiotherapy with {sup 177} Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

Energy Technology Data Exchange (ETDEWEB)

Rodriguez C, J.; Murphy, C.A. de; Pedraza L, M. [Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, 14000 Mexico D.F. (Mexico); Ferro F, G. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Murphy S, E. [Hospital Santelena, 06000 Mexico D.F. (Mexico)

2006-07-01

Malignant pancreas tumours induced in athymic mice are a good model for peptide receptor targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses after administration of {sup 177}Lu-DOTA-TATE in mice as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells expressing somatostatin receptors, were implanted in athymic mice (n=18) to obtain the {sup 177}Lu-DOTA-TATE biokinetics and dosimetry. To estimate its therapeutic efficacy 87 MBq were injected in a tail vein of 3 mice and 19 days p.i. there were a partial relapse. There was an epithelial and sarcoma mixed tumour in the kidneys of mouse III. The absorbed dose to tumour, kidney and pancreas was 50.5 {+-} 7.2 Gy, 17.5 {+-} 2.5 Gy and 12.6 {+-} 2.3 Gy respectively. These studies justify further therapeutic and dosimetry estimations to ensure that {sup 177}Lu-DOTA-TATE will act as expected in man considering its kidney radiotoxicity. (Author)

Preparation of therapeutic dose of 177Lu-DOTA-TATE using a novel single vial freeze-dried kit: a comparison with 'in-situ' preparation at hospital radiopharmacy.

Science.gov (United States)

Das, Tapas; Banerjee, Sharmila; Shinto, Ajit; Kamaleshwaran, K K; Sarma, H D

2014-01-01

Patient dose of (177)Lu-DOTA-TATE, used for providing radiotherapeutic treatment to the patients suffering from cancers of neuroendocrine origin, could be prepared at the hospital radiopharmacy either 'in-situ' or by using freezedried kits. The objective of the present work is to formulate and evaluate a single vial freeze-dried DOTA-TATE kit, which is capable of producing up to 7.4 GBq (200 mCi) dose of (177)Lu-DOTA-TATE and to compare the two methodologies presently used for the preparation of the agent. Freeze-dried DOTA-TATE kits, comprising a lyophilized mixture of DOTA-TATE, gentisic acid and ammonium acetate, were prepared and used for the formulation of patient doses of (177)Lu-DOTA-TATE. The kits were subjected to detailed radiochemical evaluation and the shelf-life of the kits was determined. The pharmacokinetic behavior of the agent was studied in normal Wistar rats. These kits were utilized for treating the patients suffering from various types of neuroendocrine cancers. The freeze-dried kits were used for the preparation of up to 7.4 GBq (200 mCi) therapeutic doses of (177)Lu- DOTA-TATE with a radiochemical purity of >99% and were found to have sufficiently long shelf-life. Biological studies carried out in normal Wistar rats exhibited no significant accumulation of activity in any of the vital organs/tissue except in kidneys and non-accumulated activity showed major renal clearance. Clinical studies carried out in cancer patients exhibited accumulation of activity in the cancerous lesions and metastatic sites. The kit was useful for the convenient preparation of therapeutic dose of (177)Lu-DOTA-TATE, suitable for human administration. The use of kit is expected to reduce the batch failure and radiation exposure to the working personnel.

The added value of {sup 68}Ga-DOTA-TATE-PET to contrast-enhanced CT for primary site detection in CUP of neuroendocrine origin

Energy Technology Data Exchange (ETDEWEB)

Kazmierczak, Philipp M. [Klinikum der Universitaet Muenchen, Institut fuer Klinische Radiologie, Muenchen (Germany); Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Muenchen (Germany); Rominger, Axel; Wenter, Vera [Ludwig-Maximilians-University Hospital Munich, Department of Nuclear Medicine, Muenchen (Germany); Spitzweg, Christine; Auernhammer, Christoph [Ludwig-Maximilians-University Hospital Munich, Department of Internal Medicine II, Muenchen (Germany); Angele, Martin K. [Ludwig-Maximilians-University Hospital Munich, Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Muenchen (Germany); Rist, Carsten; Cyran, Clemens C. [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Muenchen (Germany)

2017-04-15

To quantify the additional value of {sup 68}Ga-DOTA-TATE PET/CT in comparison with contrast-enhanced CT alone for primary tumour detection in neuroendocrine cancer of unknown primary (CUP-NET). In total, 38 consecutive patients (27 men, 11 women; mean age 62 years) with histologically proven CUP-NET who underwent a contrast-enhanced {sup 68}Ga-DOTA-TATE PET/CT scan for primary tumour detection and staging between 2010 and 2014 were included in this IRB-approved retrospective study. Two blinded readers independently analysed the contrast-enhanced CT and {sup 68}Ga-DOTA-TATE PET datasets separately and noted from which modality they suspected a primary tumour. Consensus was reached if the results were divergent. Postoperative histopathology (24 patients) and follow-up {sup 68}Ga-DOTA-TATE PET/CT imaging (14 patients) served as the reference standards and statistical measures of diagnostic accuracy were calculated accordingly. The majority of confirmed primary tumours were located in the abdomen (ileum in 19 patients, pancreas in 12, lung in 2, small pelvis in 1). High interobserver agreement was noted regarding the suspected primary tumour site (Cohen's k 0.90, p < 0.001). {sup 68}Ga-DOTA-TATE PET demonstrated a significantly higher sensitivity (94 % vs. 63 %, p = 0.005) and a significantly higher accuracy (87 % vs. 68 %, p = 0.003) than contrast-enhanced CT. Ga-DOTA-TATE PET/CT compared with contrast-enhanced CT alone provides an improvement in sensitivity of 50 % and an improvement in accuracy of 30 % in primary tumour detection in CUP-NET. (orig.)

Targeted radiotherapy with 177 Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

International Nuclear Information System (INIS)

Murphy, M. A de; Pedraza L, M.; Rodriguez C, J.; Ferro F, G.; Murphy S, E.

2006-01-01

Malignant pancreas tumours induced in athymic mice are a good model for targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses and to evaluate 177 Lu-DOTA-TATE as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells, which over-express somatostatin receptors, were injected in athymic mice and 20 days later the mean tumour size was 3.08 square cm (n=3). A mean of 86.3 MBq 177 Lu-DOTA-TATE, was injected in a tail vein and 19 days after therapy the size of the tumours was 0.81 square cm. There was a partial relapse and after 16 days, when sacrificed, the mean tumour size was 8.28 cubic cm. An epithelial and sarcoma mixed tumour in the kidney of one treated mouse was found. The tumour of the control mouse was 8.61 cubic cm when sacrificed 14 days after tumour induction. Radiotherapy estimates to the tumours was 35.9-39.7 Gy and the tumours might have been completely reduced with a second therapy dose. These preliminary studies justify further therapeutic and dosimetry estimations to ensure that Lu- 177 -DOTA-TATE will act as expected in man, considering kidney radiation. (Author)

Biokinetics and dosimetry with 177Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

Science.gov (United States)

Rodríguez-Cortés, J.; de Murphy, C. Arteaga; Ferro-Flores, Ge; Pedraza-López, M.; Murphy-Stack, E.

Malignant pancreatic tumours induced in athymic mice are a good model for peptide receptor targeted radiotherapy. The objective of this research was to determine biokinetic parameters in mice, in order to estimate the induced pancreatic tumour absorbed doses and to evaluate an `in house' 177Lu-DOTA-TATE radiopharmaceutical as part of preclinical studies for targeted therapy in humans. AR42J murine pancreas cancer cells expressing somatostatin receptors, were implanted in athymic mice (nD22) to obtain biokinetic and dosimetric data of 177Lu-DOTA-TATE. The mean tumour uptake 2 h post injection was 14.76±1.9% I.A./g; kidney and pancreas uptake, at the same time, were 7.27±1.1% I.A./g (1.71±0.90%/organ) and 4.20±0.98% I.A./g (0.42±0.03%/organ), respectively. The mean absorbed dose to tumour, kidney and pancreas was 0.58±0.02 Gy/MBq; 0.23±0.01 Gy/MBq and 0.14±0.01 Gy/MBq, respectively. These studies justify further dosimetric estimations to ensure that 177Lu-DOTA-TATE will act as expected in humans.

Peptide Receptor Radionuclide Therapy with ''9''0Y DOTA TATE - First Results

International Nuclear Information System (INIS)

Artiko, V.; Sobic-Saranovic, D.; Petrovic, N.; Damjanovic, S.; Obradovic, V.

2009-01-01

Aim: The aim of this work is presentation of the preliminary results of the therapy of NETs with 90 Y DOTA TATE. Patients and methods: We investigated 15 patients with various neuroendocrine tumors. In all of them, together with other laboratory analyses and imaging methods, scintigraphy with somatostatin analogues was performed (in 3 with 111 In Octreoscan and in the other 4 with 99m Tc Tektrotyd) and high tumor uptake observed. The therapy was performed with 2-4,5 GBq 90 Y DOTA TATE per patient per one cycle, in the slow infusion in the physiological liquid (150 ml/15 min).Between the cycles, there was a time delay of 6-8 weeks. 30 minutes before the therapy, patients began receiving the infusion of amino acids (arginine and lysine) which lasted 4h. Before that, all therapies with somatostatin analogues were withdrawn. 24h-96h after the therapy, ''bremsstrahlung'' whole body imaging, SPECT and particular planar images were performed with gamma camera. Results: Analysis of the ''bremsstrahlung'' images showed uptake of the radiopharmaceutical in the liver, but the most of the activity was observed in the regions of the ''hot spots'' registered with previous 99m Tc Tektrotyd and 111 In Octreoscan images. According to our results, after the therapy, in two patients occurred progressive disease (PD), in seven stable disease (SD), and in six partial remission (PR). Up to now, there were no major clinical side effects hepatic function. Transient pancytopenia occurred in two patients, and impairment of kidney function in one. Conclusion: In spite of insufficient data, beneficial effects on clinical symptoms, hormone production and tumor proliferation were found, without major clinical side effects. Thus, according to preliminary results, treatment with 90 Y DOTA TATE is feasible method and might be useful for the management of patients with inoperable or disseminated neuroendocrine tumors. (author)

A Model of Small Capacity Power Plant in Tateli Village, North Sulawesi

Science.gov (United States)

Sangari, F. J.; Rompas, P. T. D.

2017-03-01

The electricity supply in North Sulawesi is still very limited so ubiquitous electric current outage. It makes rural communities have problems in life because most uses electrical energy. One of the solutions is a model of power plants to supply electricity in Tateli village, Minahasa, North Sulawesi, Indonesia. The objective of this research is to get the model that generate electrical energy for household needs through power plant that using a model of Picohydro with cross flow turbine in Tateli village. The method used the study of literature, survey the construction site of the power plant and the characteristics of the location being a place of research, analysis of hydropower ability and analyzing costs of power plant. The result showed that the design model of cross flow turbines used in pico-hydro hydropower installations is connected to a generator to produce electrical energy maximum of 3.29 kW for household needs. This analyze will be propose to local government of Minahasa, North Sulawesi, Indonesia to be followed.

An Interview with Marcia Tate: Formative Assessment and Brain Based Learning

OpenAIRE

Shaughnessy, Michael

2016-01-01

In this interview, Dr. Marcia Tate discusses her work and focuses on critical issues in brain based learning, and the need for both formative and summative assessment. Tangential issues such as grade retention, and response to intervention are also discussed. It is hope that this interview will assist teachers in the instructional and learning process and aid in both formative and summative assessment.  

Targeted radiotherapy with {sup 177} Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

Energy Technology Data Exchange (ETDEWEB)

Murphy, M. A de; Pedraza L, M. [Department of Nuclear Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico D.F. (Mexico); Rodriguez C, J. [Faculty of Medicine, UAEM, Toluca, Estado de Mexico (Mexico); Ferro F, G. [ININ, 52045 Estado de Mexico (Mexico); Murphy S, E. [Hospital Santelena, Mexico D.F. (Mexico)

2006-07-01

Malignant pancreas tumours induced in athymic mice are a good model for targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses and to evaluate {sup 177}Lu-DOTA-TATE as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells, which over-express somatostatin receptors, were injected in athymic mice and 20 days later the mean tumour size was 3.08 square cm (n=3). A mean of 86.3 MBq {sup 177}Lu-DOTA-TATE, was injected in a tail vein and 19 days after therapy the size of the tumours was 0.81 square cm. There was a partial relapse and after 16 days, when sacrificed, the mean tumour size was 8.28 cubic cm. An epithelial and sarcoma mixed tumour in the kidney of one treated mouse was found. The tumour of the control mouse was 8.61 cubic cm when sacrificed 14 days after tumour induction. Radiotherapy estimates to the tumours was 35.9-39.7 Gy and the tumours might have been completely reduced with a second therapy dose. These preliminary studies justify further therapeutic and dosimetry estimations to ensure that Lu-{sup 177}-DOTA-TATE will act as expected in man, considering kidney radiation. (Author)

Bulk Scale Formulation of Therapeutic Doses of Clinical Grade Ready-to-Use 177Lu-DOTA-TATE: The Intricate Radiochemistry Aspects.

Science.gov (United States)

Mathur, Anupam; Prashant, Vrinda; Sakhare, Navin; Chakraborty, Sudipta; Vimalnath, K V; Mohan, Repaka Krishna; Arjun, Chanda; Karkhanis, Barkha; Seshan, Ravi; Basu, Sandip; Korde, Aruna; Banerjee, Sharmila; Dash, Ashutosh; Sachdev, Satbir Singh

2017-09-01

177 Lu-DOTA-TATE is a clinically useful and promising therapeutic radiopharmaceutical for peptide receptor radionuclide therapy of neuroendocrine tumors (NETs) overexpressing somatostatin receptors. Currently, the radiopharmaceutical is prepared in-house at nuclear medicine centers, thereby restricting its use to limited centers only. In this article, the authors describe systematic studies toward bulk scale formulation of "ready-to-use" 177 Lu-DOTA-TATE using medium specific activity 177 Lu (740-1110 GBq/mg) at a centralized radiopharmacy facility. In an optimized protocol, 177 Lu-DOTA-TATE synthesis was carried out by direct heating of 177 LuCl 3 (Sp. act. 740-1110 GBq/mg) with DOTA-TATE peptide (1.5-3.0 equivalents) in ammonium acetate buffer (0.2 M) containing 2,5-dihydroxy benzoic acid (gentisic acid). Thereafter, the crude labeled product was purified using a Sep-Pak ® C18 column and diluted with acetate buffer-gentisic acid (1.5% w/v) solution to final radioactive concentration of 740 MBq/mL. This was further sterilized and dispensed as 7.4 GBq patient dose/vial with 2 days postformulation calibration. A peptide/metal ratio of 1.5-3.0 is essential for complexation wherein radiolabeling yields >90% are obtained minimizing free 177 Lu waste. For formulation of 7.4 GBq patient dose (2 days postproduction), even specific activity of about 555 GBq/mg was found to be adequate for the radiometal. The ready-to-use 740 MBq/mL 177 Lu-DOTA-TATE formulation with gentisic acid (1.5% w/v) is observed to be safe for human use for more than 1 week (radiochemical purity >98%) from the day of production when stored at -70°C. However, the target specificity may get affected beyond 2 days as the total peptide content for 7.4 GBq dose may exceed the critical peptide limit of 300 μg. Patient treatment carried with several batches of present formulation in diseased NET patients exhibited desired distribution at the tumor and its metastatic site. A ready

Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

Science.gov (United States)

Cwikla, Jaroslaw B; Mikolajczak, Renata; Pawlak, Dariusz; Buscombe, John R; Nasierowska-Guttmejer, Anna; Bator, Andrzej; Maecke, Helmut R; Walecki, Jerzy

2008-07-01

The imaging of neuroendocrine tumors has become one of the most significant areas in nuclear oncology. In an attempt to provide high-quality imaging and possible sensitivity at a reduced cost, time, and radiation dose, several (99m)Tc agents have been proposed. The aim of this initial study was to compare the tumor uptake and biodistribution of 2 new 6-hydrazinopyridine-3-carboxylic acid (HYNIC)-derivatized Tyr(3)-octreotide analogs, (99m)Tc-[HYNIC,Tyr(3)]octreotide ((99m)Tc-TOC) and (99m)Tc-[HYNIC,Tyr(3),Thr(8)]octreotide ((99m)Tc-TATE), in patients with somatostatin receptor-expressing tumors. Each of 12 patients with proven gastrointestinal pancreatic neuroendocrine tumors received a mean activity of 520 MBq of (99m)Tc-TOC and (99m)Tc-TATE. Scintigraphy with both tracers was performed 3-4 h after their injection using standard whole-body and SPECT imaging. The images were reviewed subjectively by 2 readers, who reported tumor uptake lesion by lesion. Both radiotracers demonstrated concordance between the results in 7 patients (58%). In total, 110 sites of disease were identified with (99m)Tc-TOC, compared with 115 with (99m)Tc-TATE. There was 1 case in which (99m)Tc-TOC identified sites of disease not seen on (99m)Tc-TATE imaging but 4 cases in which some sites of disease were seen with (99m)Tc-TATE and not (99m)Tc-TOC. In this initial study, both tracers seem to show similar sites of tumor, with (99m)Tc-TATE having a slight edge in the total number of lesions seen, especially in lymph node metastases.

Gallium-68 DOTA-TATE Positron Emission Tomography/Computed Tomography: Scintigraphic Changes of Adrenal Glands Following Management of Ectopic Cushing's Syndrome by Steroidogenesis Inhibitors

International Nuclear Information System (INIS)

Huang, Yu-Ting; Aziz, Shaikh Irfan; Kumar, Aravind S. Ravi

2014-01-01

In the era of emerging functional imaging techniques, an understanding of the effects of hormonal therapies on the scintigraphic appearance of endocrine organs is desirable to minimize the erroneous scan interpretation. The mechanisms by which changes in the scintigraphic appearance of endocrine organs occur however sometimes remain ambiguous. This case demonstrates the gallium-68 (Ga-68) DOTA-TATE positron emission tomography/computed tomography (CT) appearance of adrenal glands following management with steroidogenesis inhibitors. The potential mechanisms underlying this change are discussed. A 17-year-old boy with adrenocorticotropic hormone (ACTH) dependent Cushing's syndrome secondary to ectopic ACTH secretion underwent pre- and post-metyrapone and dexamethasone treatment Ga-68 DOTA-TATE scans 4 months apart. Pretreatment, both adrenals demonstrated normal symmetrical prominent Ga-68 DOTA-TATE uptake and normal CT appearance. The posttherapy scan revealed marked symmetrical suppression of Ga-68 DOTA-TATE uptake, but with bilateral adrenal hypertrophy on CT

Safety, Pharmacokinetics and Dosimetry of a Long-Acting Radiolabeled Somatostatin Analogue 177Lu-DOTA-EB-TATE in Patients with Advanced Metastatic Neuroendocrine Tumors.

Science.gov (United States)

Zhang, Jingjing; Wang, Hao; Jacobson Weiss, Orit; Cheng, Yuejuan; Niu, Gang; Li, Fang; Bai, Chunmei; Zhu, Zhaohui; Chen, Xiaoyuan

2018-04-13

Radiolabeled somatostatin analogue therapy has become an established treatment method for patients with well to moderately differentiated unresectable or metastatic neuroendocrine tumors (NETs). The most frequently used somatostatin analogues in clinical practice are octreotide and octreotate. However, both peptides showed suboptimal retention within tumors. The aim of this first-in-human study is to explore the safety and dosimetry of a long-acting radiolabeled somatostatin analogue, lutetium-177-1, 4, 7, 10-tetra-azacyclododecane-1, 4, 7, 10-tetraacetic acid-Evans blue-octreotate ( 177 Lu-DOTA-EB-TATE). Methods: Eight patients (6 males and 2 females; age range, 27-61 y) with advanced metastatic neuroendocrine tumors were recruited. Five patients received a single dose 0.35-0.70 GBq (9.5-18.9 mCi) of 177 Lu-DOTA-EB-TATE and underwent serial whole body planar and single-photon emission computed tomography-computed tomography (SPECT-CT) scans at 2, 24, 72, 120 and 168 h after injection. The other 3 patients received intravenous injection of 0.28-0.41 GBq (7.5-11.1 mCi) of 177 Lu-DOTATATE for the same imaging acquisition procedures at 1, 3, 4, 24 and 72 h after injection. The dosimetry was calculated using the OLINDA/EXM 1.1 software. Results: Administration of 177 Lu-DOTA-EB-TATE was well tolerated, with no adverse symptoms being noticed or reported in any of the patients. Compared with 177 Lu-DOTATATE, 177 Lu-DOTA-EB-TATE showed extended circulation in the blood and achieved 7.9-fold increase of tumor dose delivery. The total body effective doses were 0.205 ± 0.161 mSv/MBq for 177 Lu-DOTA-EB-TATE and 0.174 ± 0.072 mSv/MBq for 177 Lu-DOTATATE. Significant dose delivery increases to the kidneys and bone marrow were also observed in patients receiving 177 Lu-DOTA-EB-TATE than those receiving 177 Lu-DOTATATE (3.2 and 18.2-fold, respectively). Conclusion: By introducing an albumin binding moiety, 177 Lu-DOTA-EB-TATE showed remarkably higher uptake and retention in NET

75 FR 38127 - Visteon Systems, LLC North Penn Plant Electronics Products Group Including On-Site Leased Workers...

Science.gov (United States)

2010-07-01

..., North Penn Plant, Electronics Products Group to be covered by this certification. The intent of the... North Penn Plant Electronics Products Group Including On-Site Leased Workers From Ryder Integrated... Certification Regarding Eligibility To Apply for Worker Adjustment Assistance and Alternative Trade Adjustment...

[99mTc]Demotate 2 in the detection of sst2-positive tumours: a preclinical comparison with [111In]DOTA-tate

International Nuclear Information System (INIS)

Maina, Theodosia; Nock, Berthold A.; Cordopatis, Paul; Bernard, Bert F.; Breeman, Wout A.P.; Gameren, Arthur van; Berg, Ria van den; Krenning, Eric P.; Jong, Marion de; Reubi, Jean-Claude

2006-01-01

The aim of this study was to evaluate [ 99m Tc]Demotate 2 ([ 99m Tc-N 4 0-1 ,Asp 0 ,Tyr 3 ]octreotate) as a candidate for in vivo imaging of sst 2 -positive tumours and to compare it with [ 111 In]DOTA-tate ([ 111 In-DOTA 0 ,Tyr 3 ]octreotate). Labelling of Demotate 2 with 99m Tc was performed at room temperature using SnCl 2 as reductant in the presence of citrate at alkaline pH. Radiochemical analysis involved ITLC and HPLC methods. Peptide conjugate affinities for sst 2 were determined by receptor autoradiography on rat brain cortex sections using [DOTA 0 , 125 I-Tyr 3 ]octreotate as the radioligand. The affinity profile of Demotate 2 for human sst 1 -sst 5 was studied by receptor autoradiography in cell preparations using the universal somatostatin radioligand [ 125 I][Leu 8 ,(D)Trp 22 ,Tyr 25 ]somatostatin-28. The internalisation rates of [ 99m Tc]Demotate 2 and [ 111 In]DOTA-tate were compared in sst 2 -positive and -negative control cell lines. Biodistribution of radiopeptides was studied in male Lewis rats bearing CA20948 tumours. Peptide conjugates showed selectivity and a high affinity binding for sst 2 (Demotate 2 IC 50 =3.2 nM and DOTA-tate IC 50 =5.4 nM). [ 99m Tc]Demotate 2, like [ 111 In]DOTA-tate, internalised rapidly in all sst 2 -positive cells tested, but not in sst 2 -negative control cells. After injection in CA20948 tumour-bearing rats both radiopeptides showed high and specific uptake in the sst 2 -positive organs and in the implanted tumour and rapid excretion from non-target tissues via the kidneys. [ 99m Tc]Demotate 2, similarly to the known sst 2 -targeting agent [ 111 In]DOTA-tate, showed promising biological qualities for application in the scintigraphy of sst 2 -positive tumours. (orig.)

Robert Wood Johnson Foundation

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Robert Wood Johnson Foundation Search How We Work Our Focus Areas About RWJF Search Menu How We Work Grants ... Learn more For Grantees and Grantseekers The Robert Wood Johnson Foundation funds a wide array of programs ...

Modification of the Penn State Reactor to allow transverse and rotational core motion to increase operational versatility

International Nuclear Information System (INIS)

Hughes, Daniel E.

1994-01-01

At Penn State the Nuclear Engineering students have the opportunity to perform experiments in reactor physics, work with reactor and radiation instrumentation, and operate a nuclear reactor. These activities are done at the Penn State Breazeale Reactor (PSBR), a General Atomics Mark III TRIGA reactor. Unfortunately this activity alone can not fully support the facility. The PSBR is mandated by Penn State to provide a portion of its operating budget by selling services to users outside as well as inside Penn State. In order to increase the marketability of PSBR an upgrade program was started to increase the quality and versatility of operation. The PSBR is the longest operating university reactor in the United States. The first phase of the upgrade program began in 1992. The quality of operation was increased by replacing a 1965 vintage console with a more reliable digital control and monitoring system. The present phase of the upgrade program is to increase the versatility of operation by modifying the reactor to allow transverse and rotational core motion. Adding two more degrees of motion to the reactor core increases the capability of the facility to meet the needs of present and future users. This upgrade is being financed by a grant from the Department of Energy and matching funds from Penn State. (author)

Art engagement and mental health: experiences of service users of a community-based arts programme at Tate Modern, London.

Science.gov (United States)

McKeown, Eamonn; Weir, Hannele; Berridge, Emma-Jane; Ellis, Liz; Kyratsis, Yiannis

2016-01-01

To examine the experiences of mental health service users who took part in an arts-based programme at Tate Modern, a major London art gallery. Exploratory qualitative design. Data were collected using in-depth semi-structured interviews with 10 mental health service users who had taken part in a community-based programme at Tate Modern. Additionally, six art educators from Tate Modern were interviewed. Concepts that emerged from the text were identified using thematic analysis. All participants valued the gallery-based programme. The three overarching thematic areas were: the symbolic and physical context in which the programme workshops were located; the relational and social context of the programme workshops; and reflections on the relationship between the arts-based programme and subsequent mental health. Art galleries are increasingly seen to function as vehicles for popular education with mental health service users. This study adds to the growing body of evidence related to how mental health service users experience and reflect on arts-related programmes targeted at them. This study indicates that emphasis on how users experience gallery-based programmes may contribute to a more nuanced understanding of the relationship between art and mental health. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.).

Science.gov (United States)

Hosono, Makoto; Ikebuchi, Hideharu; Nakamura, Yoshihide; Nakamura, Nobutaka; Yamada, Takahiro; Yanagida, Sachiko; Kitaoka, Asami; Kojima, Kiyotaka; Sugano, Hiroyasu; Kinuya, Seigo; Inoue, Tomio; Hatazawa, Jun

2018-04-01

Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown in this guideline are considered internationally useful as well. Only the original Japanese version is the formal document.

Comparison of Ga-68 DOTA-TATE and Ga-68 DOTA-LAN PET/CT imaging in the same patient group with neuroendocrine tumours: preliminary results.

Science.gov (United States)

Demirci, Emre; Ocak, Meltem; Kabasakal, Levent; Araman, Ahmet; Ozsoy, Yildiz; Kanmaz, Bedii

2013-08-01

Recent studies have suggested that PET imaging with Ga-68-labelled DOTA-somatostatin analogues such as octreotide and octreotate is useful in diagnosing neuroendocrine tumours (NETs) and has superior value over both computed tomography and planar and SPECT somatostatin receptor scintigraphy. The aim of the present study was to evaluate the role of Ga-68 DOTA-lanreotide (Ga-68-DOTA-LAN) in patients with somatostatin receptor (sst)-expressing tumours and to compare the results of Ga-68 DOTA-D-Phe1-Tyr3-octreotate (Ga-68-DOTA-TATE) in the same patient population. Twelve patients with NETs who were referred to our department for somatostatin receptor scintigraphy were included in the study. There were four patients with well-differentiated neuroendocrine tumour (WDNET) grade 1, two patients with WDNET grade 2, and three patients with poorly differentiated neuroendocrine carcinoma (PDNEC) grade 3. There was also one patient with medullary thyroid cancer, one patient with meningioma and one patient with MEN-1. All patients underwent two consecutive PET imaging studies with Ga-68-DOTA-TATE and Ga-68 DOTA-LAN. All images were evaluated visually, and maximum standardized uptake value was calculated for quantitative evaluation. On visual examination of maximum intensity projection images, GA-68 DOTA-LAN was seen to have high background activity and high bone marrow uptake. Both tracers defined 67 lesions. Ga-68 DOTA-TATE images revealed 63 (94%) clearly defined lesions, missing four lesions. In contrast, Ga-68 DOTA-LAN images defined only 23 (44%) lesions, missing 44 (56%) lesions. Thirty-two bone lesions were detected on Ga-68-DOTA-TATE images. Among them, only 11 (34%) were positive on Ga-68 DOTA-LAN images, whereas 21 (66%) were negative. When we evaluated liver, mediastinum and gastrointestinal tract lesions, Ga-68 DOTA-LAN was seen to be positive for 12 (34%) lesions and negative for 23 (66%) lesions. Although the results are preliminary, the image quality obtained by

Crystal structure of rubidium methyl-diazo-tate.

Science.gov (United States)

Grassl, Tobias; Korber, Nikolaus

2017-02-01

The title compound, Rb + ·H 3 CN 2 O - , has been crystallized in liquid ammonia as a reaction product of the reductive ammonolysis of the natural compound streptozocin. Elemental rubidium was used as reduction agent as it is soluble in liquid ammonia, forming a blue solution. Reductive bond cleavage in biogenic materials under kinetically controlled conditions offers a new approach to gain access to sustainably produced raw materials. The anion is nearly planar [dihedral angle O-N-N-C = -0.4 (2)°]. The Rb + cation has a coordination number of seven, and coordinates to five anions. One anion is bound via both its N atoms, one by both O and N, two anions are bound by only their O atoms, and the last is bound via the N atom adjacent to the methyl group. The diazo-tate anions are bridged by cations and do not exhibit any direct contacts with each other. The cations form corrugated layers that propagate in the (-101) plane.

'½ vol. not relevant': The scrapbook of Winifred Penn-Gaskell

Directory of Open Access Journals (Sweden)

Caitlin Doherty

2014-10-01

Full Text Available The scrapbook of Winifred Penn-Gaskell – celebrated aerophilatelist and collector of aeronautica –reveals a great deal about its maker and the social and political context of early flight history in Britain. It is argued here that a ‘reading’ of the book as a non-textual object offers a predictive argument for the aesthetic and cultural representation of heavier-than-air craft and pilots in the years immediately prior to the First World War. By viewing each section of the scrapbook as parts of a contingent whole, the early-twentieth century interest in performative masculinity (physical culture and boxing becomes a part of the technological narrative of aviation development. In this paper I question the implications of branding an object such as this ‘irrelevant’ to the broader themes of the Penn-Gaskell collection, and offer some views of my own on how the notion of failure affects museological practices.

On Tate Modern’s Turbine Hall and 'The Unilever Series'

Directory of Open Access Journals (Sweden)

Wouter Davidts

2014-07-01

Full Text Available Since the opening Tate Modern in 2000, the vast space of the Turbine Hall has hosted The Unilever Series. Widely acclaimed artists Louise Bourgeois, Juan Munõz, Anish Kapoor, Olafur Eliasson, Bruce Nauman, Rachel Whiteread, Carsten Höller and most lately Doris Salcedo accepted the invitation to ‘tackle’ what is arguably the biggest museum space in the world and realized what is invariably held to be their ‘biggest work ever.’The Unilever Series is not the only large-scale installation series. In recent years, we witnessed the worldwide launch of ever-larger art commissions for increasingly vaster spaces, resulting in all the more colossal artworks. Only recently, Paris announced its own yearly art commission for the central nave of the Grand Palais, suitably entitled Monumenta. The essay examines The Unilever Series in Tate Modern’s Turbine Hall, and discuss it within the global leap in scale and massive expansion of the art and museum world, of which the London institution and its vestibule in particular are the most blatant exponents. While it is certainly true that the spectacular expansion of art installations has occurred in tandem with a profusion of large international exhibitions and ‘destination’ museum of inordinately vast proportions, the assumption that large exhibition spaces demand an art of size is too simplistic. By examining the institutional, spatial and material disposition of the Turbine Hall, I will demonstrate that it is far more than a plain and abstract emblem of the global inflation and growth of museum and exhibition spaces. It’s a distinct architectural exponent of this tendency that essentially in and of itself has informed the inflation of the artworks that have been commissioned for it.

Comparison of tumour and whole body absorbed doses of 177-Lu-DOTA-TATE and Lu-177-DOTA-NOC treatment in the same patient group

International Nuclear Information System (INIS)

Yeyin, N.; Kabasakal, L.; Akyel, R.; Demir, M.; Kanmaz, B.; Ocak, M.; Toklu, T.; Selcuk, N.

2015-01-01

Full text of publication follows. Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 labelled peptides in patients with neuroendocrine tumours (NETs) aroused great interest. An estimation of actual radiation doses to tumours is very important for therapy planning. There are several radiolabelled peptides, which can be used for PRRT with different biological behaviour. Aim: the aim of the study was to compare the tumour and normal organ absorbed doses in patients who have received Lu-177-DOTA-TATE and Lu-177 DOTA-NOC. Materials and methods: study was composed of 20 patients (M/F: 10/10, mean age: 51.5 ± 14.9) with histologically proven inoperable NETs. All patients received Lu-177-DOTA-NOC treatment 6 to 12 weeks after last Lu-177-DOTA-TATE treatment. Dosimetric calculations were performed using MIRD scheme and lesion doses were calculated using post therapy whole body images obtained at 4, 20, 44, and 68 hours after injection. Tumour volumes were determined from CT images. Thirteen blood samples beginning from time zero to 4 days after injection were obtained for bone marrow and whole body dosimetry. Results: There were 53 lesions in Lu-177-DOTA-TATE post-therapy whole body images and 49 lesions in Lu-177 DOTA-NOC post therapy images. Lesions were selected according to lesion delineation and superimposed lesions were excluded. Mean lesion absorbed dose is calculated to be 47.4 ± 53.4 and 42.9 ± 52.8 Gy per 370 MBq for Lu-177-DOTA-TATE and DOTA-NOC respectively (p>0.5). There were significantly higher absorbed doses for kidney and bone marrow after Lu-177-DOTA-NOC treatment as compared to Lu-177-DOTA-TATE treatment, which were 6.9 ± 2.7 vs 3.9 ± 1.7 (p<0.05) and 0.12 ± 0.0 vs 0.10 ± 0.0 (p<0.05) Gy, respectively. There was not any difference in plasma elimination times between two tracers. On the other hand the whole body absorbed dose was significantly higher after Lu-177-DOTA-NOC treatment, which was 0.24 ± 0.07 vs 0.20 ± 0.06 Gy (p<0

Robert's rules of order

CERN Document Server

Robert, Henry M; Balch, Thomas J; Seabold, Daniel E; Gerber, Shmuel

2011-01-01

The only authorized edition of the classic work on parliamentary procedure, with new and enhanced features, including how to conduct electronic meetings. Robert's Rules of Order is the book on parliamentary procedure for parliamentarians and anyone involved in an organization, association, club, or group and the authoritative guide to smooth, orderly, and fairly conducted meetings and assemblies. This newly revised edition is the only book on parliamentary procedure to have been updated since 1876 under the continuing program of review established by General Henry M. Robert himself, in cooperation with the official publisher of Robert's Rules. The eleventh edition has been thoroughly revised to address common inquiries and incorporate new rules, interpretations, and procedures made necessary by the evolution of parliamentary procedure, including new material relating to electronic communication and "electronic meetings."

Pennsylvania: Penn State University Integrated Pest Management Project (A Former EPA CARE Project)

Science.gov (United States)

Penn State University (PSU) is the recipient of a Level II CARE cooperative agreement targeting environmental risks in Philadelphia communities. PSU is involved in developing IPM management practices recommendations and policies.

Robert Cailliau honoured by Belgium

CERN Multimedia

2004-01-01

On 15 November, Robert Cailliau received the distinction of Commandeur de l'Ordre de Léopold from Belgium, his home country, for his pioneering work in developing the World Wide Web. Robert Cailliau worked closely with Tim Berners-Lee, the inventor of the Web.

The somatostatin receptor 2 antagonist 64Cu-NODAGA-JR11 outperforms 64Cu-DOTA-TATE in a mouse xenograft model

Science.gov (United States)

Rylova, Svetlana N.; Stoykow, Christian; Del Pozzo, Luigi; Abiraj, Keelara; Tamma, Maria Luisa; Kiefer, Yvonne; Fani, Melpomeni; Maecke, Helmut R.

2018-01-01

Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applications. The aim of this study was to perform a side-by-side comparison of the in vitro and in vivo performance of 64Cu-NODAGA-JR11 (NODAGA = 1,4,7-triazacyclononane,1-glutaric acid,4,7-acetic acid, JR11 = p-Cl-Phe-cyclo(D-Cys-Aph(Hor)-D-Aph(cbm)-Lys-Thr-Cys)D-Tyr-NH2), a somatostatin receptor 2 antagonist, with the clinically used sst2 agonist 64Cu-DOTA-TATE ((TATE = D-Phe-cyclo(Cys-Tyr-D-Trp-Lys-Thr-Cys)Thr). In vitro studies demonstrated Kd values of 5.7±0.95 nM (Bmax = 4.1±0.18 nM) for the antagonist 64/natCu-NODAGA-JR11 and 20.1±4.4. nM (Bmax = 0.48±0.18 nM) for the agonist 64/natCu-DOTA-TATE. Cell uptake studies showed the expected differences between agonists and antagonists. Whereas 64Cu-DOTA-TATE (the agonist) showed very effective internalization in the cell culture assay (with 50% internalized at 4 hours post-peptide addition under the given experimental conditions), 64Cu-NODAGA-JR11 (the antagonist) showed little internalization but strong receptor-mediated uptake at the cell membrane. Biodistribution studies of 64Cu-NODAGA-JR11 showed rapid blood clearance and tumor uptake with increasing tumor-to-relevant organ ratios within the first 4 hours and in some cases, 24 hours, respectively. The tumor washout was slow or non-existent in the first 4 hours, whereas the kidney washout was very efficient, leading to high and increasing tumor-to-kidney ratios over time. Specificity of tumor uptake was proven by co-injection of high excess of non-radiolabeled peptide, which led to >80% tumor blocking. 64Cu-DOTA-TATE showed less favorable pharmacokinetics, with the exception of lower kidney uptake. Blood clearance was distinctly slower and persistent higher blood values were found at 24 hours. Uptake in the liver and lung was relatively high and also persistent. The tumor uptake was specific and similar to that of 64Cu-NODAGA-JR11 at 1 h, but release from the tumor

Tomorrow's engineers through teacher/student programs at Penn State

International Nuclear Information System (INIS)

Davidson, C.

1992-01-01

Interest in math and science increases when the problems and topics are current and socially relevant. A course that integrates various sciences requires a solid foundation in mathematics and an understanding that real life consists of an interaction of the basic sciences. One topical area that requires the understanding of math and science and affects our society is radiation. Although nuclear issues are prevalent in the news, very few secondary science educators receive much formal training in radiation and nuclear science. A strong push for educational programs on this topic by the U.S. Atomic Energy Commission and state departments of education began in the late 1960s and early 1970s. Through this effort, Pennsylvania State University (Penn State) developed the Nuclear Concepts Institute for secondary science teachers and has continued its involvement with educational programs in nuclear science for teachers and students. From discussions with teachers and students along with formal and informal surveys, the programs have had a positive impact on teachers' interest in learning more about nuclear science and on students' choices to enter nuclear engineering or a related field. The paper discusses the Nuclear Concepts Program; formation of the American Nuclear Science Teachers Association (ANSTA); ANSTA projects; other Penn State educational programs; and impact of education programs

Penn State Radar Systems: Implementation and Observations

Science.gov (United States)

Urbina, J. V.; Seal, R.; Sorbello, R.; Kuyeng, K.; Dyrud, L. P.

2014-12-01

Software Defined Radio/Radar (SDR) platforms have become increasingly popular as researchers, hobbyists, and military seek more efficient and cost-effective means for radar construction and operation. SDR platforms, by definition, utilize a software-based interface for configuration in contrast to traditional, hard-wired platforms. In an effort to provide new and improved radar sensing capabilities, Penn State has been developing advanced instruments and technologies for future radars, with primary objectives of making such instruments more capable, portable, and more cost effective. This paper will describe the design and implementation of two low-cost radar systems and their deployment in ionospheric research at both low and mid-latitudes. One radar has been installed near Penn State campus, University Park, Pennsylvania (77.97°W, 40.70°N), to make continuous meteor observations and mid-latitude plasma irregularities. The second radar is being installed in Huancayo (12.05°S, -75.33°E), Peru, which is capable of detecting E and F region plasma irregularities as well as meteor reflections. In this paper, we examine and compare the diurnal and seasonal variability of specular, non- specular, and head-echoes collected with these two new radar systems and discuss sampling biases of each meteor observation technique. We report our current efforts to validate and calibrate these radar systems with other VHF radars such as Jicamarca and SOUSY. We also present the general characteristics of continuous measurements of E-region and F-region coherent echoes using these modern radar systems and compare them with coherent radar events observed at other geographic mid-latitude radar stations.

Popolnenije art-kollektsii

Index Scriptorium Estoniae

2008-01-01

Londoni kunstikoguja Anthony d'Offray kinkis oma kaasaegse kunsti kogu kunstigaleriile Tate Modern. Kogus on 232 tööd Andy Warholilt ja 69 fotot Diane Arbusilt. Esindatud on Jeff Koons, Gilbert ja George, Damien Hirst, Willem de Kooning, Robert Mapplethorpe

Penn gap rule in phase-change memory materials: No clear evidence for resonance bonds

Directory of Open Access Journals (Sweden)

K. Shimakawa

2015-04-01

Full Text Available Although a proposal of resonance bonds in crystalline phase-change materials based on the GeSbTe system has been provided, we do not find any clear evidence in favor of the proposal. The ellipsometric study demonstrates that a change in the high frequency dielectric constant ε∞ between the amorphous and crystalline phases is only scaled by the average bandgap (the Penn gap rule. Even for a pure antimony film, regarded as a prototype resonance bonding material, ε∞ was found to follow the Penn gap rule. Experimentally, we did not find any evidence of a significant change in the optical transition matrix element during the phase change, which is necessary to support the idea of resonance bonds.

68Ga DOTA-TATE PET/CT allows tumor localization in patients with tumor-induced osteomalacia but negative 111In-octreotide SPECT/CT.

Science.gov (United States)

Breer, Stefan; Brunkhorst, Thomas; Beil, F Timo; Peldschus, Kersten; Heiland, Max; Klutmann, Susanne; Barvencik, Florian; Zustin, Jozef; Gratz, Klaus-Friedrich; Amling, Michael

2014-07-01

Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia and low calcitriol levels as well as clinical symptoms like diffuse bone and muscle pain, fatigue fractures or increased fracture risk. Conventional imaging methods, however, often fail to detect the small tumors. Lately, tumor localization clearly improved by somatostatin-receptor (SSTR) imaging, such as octreotide scintigraphy or octreotide SPECT/CT. However, recent studies revealed that still a large number of tumors remained undetected by octreotide imaging. Hence, studies focused on different SSTR imaging methods such as 68Ga DOTA-NOC, 68Ga DOTA-TOC and 68Ga DOTA-TATE PET/CT with promising first results. Studies comparing different SSTR imaging methods for tumor localization in TIO are rare and thus little is known about diagnostic alternatives once a particular method failed to detect a tumor in patients with TIO. Here, we report the data of 5 consecutive patients suffering from TIO, who underwent both 111Indium-octreotide scintigraphy (111In-OCT) SPECT/CT as well as 68Ga DOTA-TATE PET/CT for tumor detection. While 111In-OCT SPECT/CT allowed tumor detection in only 1 of 5 patients, 68Ga DOTA-TATE PET/CT was able to localize the tumor in all patients. Afterwards, anatomical imaging of the region of interest was performed with CT and MRI. Thus, successful surgical resection of the tumor was achieved in all patients. Serum phosphate levels returned to normal and all patients reported relief of symptoms within weeks. Moreover, an iliac crest biopsy was obtained from every patient and revealed marked osteomalacia in all cases. Follow-up DXA revealed an increase in BMD of up to 34.5% 1-year postoperative, indicating remineralization. No recurrence was observed. In conclusion our data indicates that 68Ga DOTA-TATE PET/CT is an effective and promising diagnostic tool in the diagnosis of TIO, even in patients in whom 111In-OCT prior failed to detect

Penn State University ground software support for X-ray missions.

Science.gov (United States)

Townsley, L. K.; Nousek, J. A.; Corbet, R. H. D.

1995-03-01

The X-ray group at Penn State is charged with two software development efforts in support of X-ray satellite missions. As part of the ACIS instrument team for AXAF, the authors are developing part of the ground software to support the instrument's calibration. They are also designing a translation program for Ginga data, to change it from the non-standard FRF format, which closely parallels the original telemetry format, to FITS.

Robert Aumann

DEFF Research Database (Denmark)

Hansen, Pelle Guldborg

2007-01-01

In this interview Nobel Prize Winner Robert Aumann talks about how he was initially drawn into game theory, when he came to think of formalizing the folk-theorem, the proper role of game theory in relation to other disciplines and why behavioral game theory probably won't last long.......In this interview Nobel Prize Winner Robert Aumann talks about how he was initially drawn into game theory, when he came to think of formalizing the folk-theorem, the proper role of game theory in relation to other disciplines and why behavioral game theory probably won't last long....

Comparison of 99mTc-HYNIC-TOC and HYNIC-TATE octreotide scintigraphy with FDG PET and 99mTc-MIBI in local recurrent or distant metastatic thyroid cancers.

Science.gov (United States)

Sager, Sait; Kabasakal, Levent; Halac, Metin; Maecke, Helmut; Uslu, Lebriz; Önsel, Çetin; Kanmaz, Bedii

2013-05-01

There have been various studies for early diagnosis of local recurrent or distant metastatic thyroid cancers. The aim of this study is to evaluate the clinical utility of 99mTc-HYNIC-TOC and 99mTc-HYNIC-TATE, octreotide derivatives, to detect recurrences or distant metastases in 131I-negative thyroglobulin positive thyroid cancer patients and to compare the lesions with FDG PET and 99mTc-MIBI studies in the same patient group. Twenty differentiated thyroid cancer patients, 7 male and 13 female, mean age 54.6 ± 15.3 (range 13-78 years), were included in this study. Eighteen patients had papillary thyroid cancer and 2 had follicular thyroid cancer. Fifteen patients received HYNIC-TOC and 5 patients received HYNIC-TATE as a radiopharmaceutical. All patients underwent whole-body scan 1 and 4 hours after injection of octreotide derivatives and SPECT imagings were performed from the suspicious sites. The lesions that were seen in 99mTc-HYNIC-TOC and 99mTc-HYNIC-TATE studies were compared with 99mTc-MIBI and FDG-PET studies. Among 99mTc-HYNIC-TOC and 99mTc-HYNIC-TATE scintigraphies, 15 patient studies were evaluated as true positive (75%) and 5 were false negative (25%). The total number of lesions in octreotide scintigraphy was 48 in 20 patients. Of 20 patients, 19 had FDG-PET study, 15 of them were evaluated as true positive (78.9%), and 4 them were evaluated as false negative (21.1%). Total number of lesions in FDG PET was 74. 99mTc-MIBI study was positive in 11 patients (55%) and negative in 9 patients (45%). Total number of lesions in 99mTc-MIBI was 25. Technetium-labeled somatostatin receptor scintigraphy analogues HYNIC-TOC and HYNIC-TATE are useful imaging alternatives in somatostatin receptor expressing thyroid cancer patients. Radiolabeling is easy and they are readily available for routine use.

Éloge to Robert Fox

Directory of Open Access Journals (Sweden)

Efthymios Nicolaidis

2017-12-01

Full Text Available The 20th Alexandre Koyré Medal awarded since 1968 to prominent historians of science was awarded to Robert Fox, leading historian of European science of the period from the 18th to the beginnings of the 20th century. The Medal was presented to Robert Fox during the 7th International Conference of the European Society for the History of Science, Prague, 23 September 2016, and the Éloge describes his career and work.

Robert W Floyd

Indian Academy of Sciences (India)

scientists - Zohar Manna, an authority on the verification of software systems, Robert. Tarjan ... He began as a self taught computer operator, and then went ... important subfields of computer science: the theory of parsing, the semantics of.

Undergraduate recruitment strategies at Penn State's School of Forest Resources

OpenAIRE

Harper, Betty

2004-01-01

Enrollment declines in natural resources programs across the nation since the mid-nineties have raised concerns about the future of natural resources education. Since its peak in 1998, enrollment in Penn State's School of Forest Resources has dropped from a record high of 535 to 315 in fall 2003. At the same time state and federal agencies seeking to maintain and diversify their workforce are facing unprecedented rates of retirement. To address this issue, the School of Forest Resources is co...

75 FR 81331 - Surety Companies Acceptable on Federal Bonds: Termination-Penn Millers Insurance Company

Science.gov (United States)

2010-12-27

... should be accepted from this company, and bonds that are continuous in nature should not be renewed. The... DEPARTMENT OF THE TREASURY Fiscal Service Surety Companies Acceptable on Federal Bonds: Termination--Penn Millers Insurance Company AGENCY: Financial Management Service, Fiscal Service, Department...

FEASIBILITY ANALYSIS FOR INSTALLING A CIRCULATING FLUIDIZED BED BOILER FOR COFIRING MULTIPLE BIOFUELS AND OTHER WASTES WITH COAL AT PENN STATE UNIVERSITY

International Nuclear Information System (INIS)

Bruce G. Miller; Sharon Falcone Miller; Robert Cooper; Douglas Donovan; John Gaudlip; Matthew Lapinsky; William Serencsits; Neil Raskin; Dale Lamke; Joseph J. Battista

2001-01-01

The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) is performing a feasibility analysis on installing a state-of-the-art circulating fluidized bed (CFB) boiler and ceramic filter emission control device at Penn State's University Park campus for cofiring multiple biofuels and other wastes with coal, and developing a test program to evaluate cofiring multiple biofuels and coal-based feedstocks. Penn State currently operates an aging stoker-fired steam plant at its University Park campus and has spent considerable resources over the last ten to fifteen years investigating boiler replacements and performing life extension studies. This effort, in combination with a variety of agricultural and other wastes generated at the agricultural-based university and the surrounding rural community, has led Penn State to assemble a team of fluidized bed and cofiring experts to assess the feasibility of installing a CFB boiler for cofiring biomass and other wastes along with coal-based fuels. The objective of the project is being accomplished using a team that includes personnel from Penn State's Energy Institute and the Office of Physical Plant, Foster Wheeler Energy Services, Inc., and Cofiring Alternatives

Particle transport methods for LWR dosimetry developed by the Penn State transport theory group

International Nuclear Information System (INIS)

Haghighat, A.; Petrovic, B.

1997-01-01

This paper reviews advanced particle transport theory methods developed by the Penn State Transport Theory Group (PSTTG) over the past several years. These methods have been developed in response to increasing needs for accuracy of results and for three-dimensional modeling of nuclear systems

Robert Oppenheimer

International Nuclear Information System (INIS)

Rival, M.

1995-01-01

Graduate from Harvard, reputed professor, founder of the first theoretical physics high school of the Usa, Robert Oppenheimer is nominated in 1942 scientific director of the ''Y project'', the research program for the nuclear weapon fabrication. This book describes its life and the evolution of the Los Alamos researches up to the first test, its opposition to the thermo-nuclear weapon, and the maccarthysm period. (A.B.)

Renal toxicity of 2 cycles of peptide receptor radionuclide therapy as determined by serial measurements of the Glomerular Filtration Rate (GFR): comparison between Y-90 DOTA-TATE and Lu-177 DOTA-TATE

International Nuclear Information System (INIS)

Baum, R.P.; Prasad, V.

2007-01-01

Full text: Aim: To determine the effect of peptide receptor radionuclide therapy on GFR after 2 cycles of Y-90-DTATATE as compared to Lu-177-DOTA-TATE. Methods: Group A (Y-90), Group B (Lu-177). Group A1: 24 pts (age 60.5±11a), injected with 4.00± 0.72 GBq of Y-90 (1st cycle). Group A2: 16 pts (age 62.2±9.4a, followed up after 7.8 GBq±0.82 GBq of Y-90 (after 2nd cycle). Group B1: 14 pts (age 62.2±10.6a) 4.8± 0.8 GBq Lu-177 (1st cycle). Group B2: 6 patients (age 58.5±12a) after 9.57±1.5 GBq of Lu-177 (after 2nd cycle). GFR was determined using 110- 185 MBq of Tc-99m DTPA before and 3-4 months after therapy. Absolute/normalized values for GFR pre/post PRRT were compared (paired T-test).The effect of total amount of radioactivity administered, pre-existing diabetes, hypertension and age on renal function post 2 cycles of PRRT were also evaluated. Results: In group A1 normalized GFR dropped by 2% (absol. GFR fall: 2 ml/min) as compared to 16% in group A2 (absol. GFR fall: 7 ml/min). Baseline normalized/absol. GFR values were 1.02/87.5 ml/min in subgroup A1 and 1.02 / 86.5 ml/min in A2. The fall in both, the absolute and normalized GFR values was not significant after the 1st cycle (p=0.555), but was significant (p= 0.007) after the 2nd PRRT. In group B1 there was a fall of normalized GFR value by 10% vs. 8% in group B2. The fall in absol. GFR value was 7.7 ml/min in group B1 and 9.7 ml/min in group B2. Baseline normalized GFR values was 0.86 and 0.89 in subgroups B1 and B2, respectively. Baseline absol. GFR value was 78.3 ml/min and 81 ml/min in subgroups B1 and B2. The fall in the absol. GFR values was significant after the 1st cycle (p=.009), but was not significant (p=0.486) after the 2nd cycle of PRRT. The fall in normalized GFR value was not significant in both subgroups (p=0.07 after 1st cycle and p=0.49 after 2nd cycle). No correlation between the activity administered and the percentage change in the GFR values in both the groups (Pearson's correlation

THE DEMOKTESIS OF ROBERT NOZICK A DEMOKTESIS DE ROBERT NOZICK

Directory of Open Access Journals (Sweden)

Luiz Felipe Netto de Andrade e Silva Sahd

2008-04-01

Full Text Available the present article aims at reconstructing Robert Nozick’s cen-tral arguments about the extreme positions held by North American li-bertarians who do not distinguish between Welfare state and totalitarian state. Despite divergences on a pivotal question, that of the state, there are some affinities between Nozick and this current of thought. Contrary to the anarchist theory, the Minimal state is preferable to the state of nature as described by John locke.O presente artigo tem como objetivo reconstruir argumentos cen-trais, desenvolvidos por Robert Nozick, acerca das posições extremas que não diferenciam Estado-providência e Estado totalitário na política dos libertarianos norte-americanos, isto é, sobre as afinidades percebidas por Nozick com as teses desta corrente de pensamento, embora se afastando num ponto essencial: a questão do Estado. Ao contrário da teoria anar-quista, o Estado mínimo é preferível ao estado de natureza, tal como John locke o descreve.

Robert Adrian X / Robert Adrian X ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Adrian X, Robert

2006-01-01

1997. a. Ljubljanas tehtud intervjuu 1972. aastast Viinis elava kanada kunstniku Robert Adrian X-ga (sünd. 1935), kes töötas 1970-ndate lõpul ja 1980-ndate alguses telefoni, faksi ja varaste kirjakstisüsteemidega kunstiprojektide kallal, osales 1970-ndate ja 1980-ndate multimeediaprojektides

Introduction to special issue: Robert Jay Kastenbaum (1932-2013).

Science.gov (United States)

Fulton, Robert; Klass, Dennis; Doka, Kenneth J; Kastenbaum, Beatrice

The three pieces in this section introduce the Festschrift celebrating the works and influence of Omega: Journal of Death and Dying's founding editor, Robert Kastenbaum. Robert Fulton, an early Associate Editor of the Journal begins with some personal reflections on Kastenbaum. Klass and Doka then describe the nature of the Festschrift. A closing coda by Robert Kastenbaum's wife, Beatrice Kastenbaum, reminds us of the person behind the work.

Robert Smithsoni ülevaade

Index Scriptorium Estoniae

1999-01-01

Ameerika maakunstniku Robert Smithsoni (1938-1973) retrospektiivnäitus 12. sept.-ni Stockholmi Moodsa Kunsti Muuseumis. Kunstnikule maailmakuulsuse toonud tööst, 1970. a. Utah' osariigi Suurde Soolajärve ehitatud spiraalmuulist "Spiral Jetty".

Experimental and Computational Instrumentation for Rotorcraft Noise and Vibration Control Research at the Penn State Rotorcraft Center

National Research Council Canada - National Science Library

Smith, Edward

2001-01-01

A team of faculty at the Penn State Rotorcraft Center of Excellence has integrated five new facilities into a broad range of research and educational programs focused on rotorcraft noise and vibration control...

New CERN DG - AIP awards and prizes

CERN Multimedia

2008-01-01

The CERN Council has appointed Rolf-Dieter Heuer to succedd Robert Aymar as CERN's director general. Yu Lu, a theoretical physics and research fellow in the institute of physics at the Chinese Academy of Sciences, is the recipient of the 2008 Tate Medal for International Leadership in Physics from the American Institute of Physics (AIP)

Rhododendron farrerae Tate ex Sweet (Ericaceae, a Reconfirmed Species in Taiwan

Directory of Open Access Journals (Sweden)

Sheng-You Lu

2010-06-01

Full Text Available Rhododendron farrerae Tate ex Sweet was first recorded in Taiwan by Kawakami in 1910. Since then, this species has been grouped with R. tashiroi Maxim. due to insufficient reports and specimens, and was eliminated from Flora of Taiwan in 1998. By examining all the specimens preserved in Taiwan herbaria and documents, we confirm that the native population of R. farrerae is actually distributed in southern Taiwan, ranging from Peitawushan to Tajen Township, in the southern part of the Central Mountain Range. The diagnostic character distinguishing R. farrerae from R. tashiroi and R. mariesii Hemsl. & E. H. Wils. is that R. tashiroi and R. mariesii bear 2-3 flowers from each bud at anthesis; in contrast, R. farrerae bears only one flower during the flowering period. We provide in this paper a detailed taxonomic treatment, morphological description, distribution map, line drawing, and a comparison table of these three species of Taiwan, together with photographs.

Ectopic ACTH and CRH co-secreting tumor localized by 68Ga-DOTA-TATE PET/CT

Science.gov (United States)

Papadakis, Georgios Z.; Bagci, Ulas; Sadowski, Samira M.; Patronas, Nicholas J.; Stratakis, Constantine A.

2015-01-01

Diagnosis of ectopic adrenocorticotropic hormone (ACTH) and corticotropin releasing hormone (CRH) co-secreting tumors causing Cushing syndrome (CS) is challenging, since these tumors are rare and their diagnosis is frequently confused with Cushing disease (CD), due to the effect of CRH on the pituitary. We report a case of a 21-year-old male who was referred to our institution with persistent hypercortisolemia and CS after undergoing unnecessary transsphenoidal surgery (TSS). 68Ga-DOTA-TATE PET/CT revealed increased tracer uptake in the thymus which was histologically proved to be neuroendocrine tumor (NET) staining positive for ACTH and CRH. Imaging with 18F-FDG PET/CT was not diagnostic. PMID:26018709

Psychometric Properties of the Penn State Worry Questionnaire for Children in a Large Clinical Sample

Science.gov (United States)

Pestle, Sarah L.; Chorpita, Bruce F.; Schiffman, Jason

2008-01-01

The Penn State Worry Questionnaire for Children (PSWQ-C; Chorpita, Tracey, Brown, Collica, & Barlow, 1997) is a 14-item self-report measure of worry in children and adolescents. Although the PSWQ-C has demonstrated favorable psychometric properties in small clinical and large community samples, this study represents the first psychometric…

Radiographic Assessment of the Robert and Lateral Views in Trapeziometacarpal Osteoarthrosis.

Science.gov (United States)

Oheb, Jonathan; Lansinger, Yuri; Jansen, Joshua A; Nguyen, Jimmy Q; Porembski, Margaret A; Rayan, Ghazi M

2015-01-01

To evaluate the effectiveness of the Robert view in assessing trapeziometacarpal arthrosis and to compare the accuracy of the Robert and lateral views in staging trapeziometacarpal (TM) joint arthrosis. Patient demographics were obtained. Four participating raters reviewed 62 randomly selected thumb x-rays of patients presenting with thumb TM joint pain. Lateral and Robert-hyperpronation views were assessed using an analysis of 13 criteria. X-rays of 62 thumbs for 58 patients were evaluated. The average patients' age was 64 (47-87) and 51 (80%) were females. The majority of X-rays evaluated fell into stage 3. Stage 2 was the second most common level of arthritis encountered and the least was stage 1. More osteophytes were encountered in the trapezium than metacarpal on both the Robert and lateral views. The Robert view was superior in detecting osteophytes on the trapezium than the lateral view. Osteophyte size varied from 1.7 to 2 mm. The lateral view displayed 61 cases with dorsal metacarpal subluxation (98%). The Robert view displayed 48 cases (77%) with radial metacarpal subluxation and 9 cases (15%) with ulnar metacarpal subluxation. Thumb metacarpal adduction deformity was encountered on the lateral view in 20 cases (32%) whereas on the Robert view it was encountered in 14 cases (23%). Subchondral sclerosis was encountered on the Robert view in 56 thumbs (90%) while it was seen on the lateral view in 52 thumbs (84%). Pantrapezial arthritis involving the STT joint was encountered equally in 16 cases (26%) on the Robert view and the lateral views. The study found a moderate level of interrater reliability on both the lateral and Robert views. With the exception of osteophytes encountered on the trapezium versus the metacarpal, there were no other statistically significant findings. This study confirms that each of the Robert and lateral views offer unique information and combining both views enhances the ability to assess radiographic disease severity, and

Lu-177 DOTA-TATE for peptide receptor radionuclide therapy (PRRT): organ-, tumor- and blood kinetics

International Nuclear Information System (INIS)

Wehrmann, C.; Senftleben, S.; Baum, R.P.

2007-01-01

Full text: Aim: Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 DOTA-TATE is used for the treatment of patients with neuroendocrine tumors. The aim of our study was to determine the organ and tumor kinetics for dosimetric calculations. Material and Methods: 130 patients (aged 60+/-11 years; 57m, 73f) with metastasized neuroendocrine tumors (somatostatin expression verified before by Ga-68 DOTA-NOC PET/CT) were treated with activities of 2.5- 7.4 GBq Lu-177 DOTA-TATE (1-5 cycles). On the basis of conjugated planar whole-body scintigraphies 0.5h, 3h, 24h, 48h and 72h p.i. the time-dependent whole-body, organ and tumor activities were determined and dosimetric calculations were performed according to the MIRD scheme using OLINDA software. Blood samples were drawn from 23 patients to estimate the absorbed dose to the red marrow. To describe the kinetics we used the following parameters: mean half-life and uptake (fraction of injected activity/dose, ID) which were calculated using the fit of the time-dependent activity curve to a mono- or bi-exponential function. Results: The renal uptake decreased for the first 3- 5 hours p.i. with a mean half-life of 1.0+/-0.5h, followed by a second phase with a longer half-life of 65+/-17h. The maximum kidney uptake was 4+/-1%. The uptake in the spleen was with 2+/-1.8% ID stable until 24 hours p.i. and then showed a decline with a half-life of 72+/-19h. The tumor uptake showed an increase until 24h p.i. to a maximum of 0.1+/-0.1% ID per unit mass and then slowly decreased with a half-life of 77+/-25h. Liver metastases showed a higher maximal uptake (0.1+/-0.1%) as compared to lymph node metastases (0.08+/-0.07%). The blood kinetics were fitted to a tri-exponential function with large variation: half-life 1: 0.2+/-0.2h; half-life 2: 2+/-1.8h and half-life 3: 21+/-10h. The following organ absorbed doses were calculated: kidneys: 5+/-2 Sv; spleen: 7+/-4 Sv; metastases: 47+/-66 Sv (44+/-38 Sv for lymph node, and 60+/-86 Sv for

An Architecture for the Electronic Church: Oral Roberts University in Tulsa, Oklahoma.

Science.gov (United States)

Grubiak, Margaret M

2016-04-01

More than a university, Oral Roberts University in Tulsa, Oklahoma, was also the headquarters for evangelist Oral Roberts's electronic church. The electronic church in America, dominated by Christian evangelicals, used technology to spread the Gospel over radio airways and television signals to a dispersed audience. Yet evangelicals like Roberts also constructed ambitious campuses in real space and time. The architecture of Oral Roberts University visualized a modern and "populuxe" image for the electronic church in the 1960s and 1970s. The university's Prayer Tower purposely alluded to the Seattle Space Needle, aligning religion and the Space Age, and the campus's white, gold, and black color palette on late modern buildings created an image of aspirational luxury, conveying Roberts's health and wealth gospel. Oral Roberts University served as a sound stage for Roberts's radio and television shows, a pilgrimage point for his audience, and a university dedicated to training evangelicals in the electronic church.

Lahkunud maailmaparandaja Robert Lepikson jäi igavesti otsijaks / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2006-01-01

Ülevaade riigikogu liikme, endise siseministri, Tallinna linnapea ja Võru maavanema Robert Lepiksoni elukäigust, meenutused tuntud ühiskonnategelastelt. Lisad: Robert Lepikson; Kõva sõnaga mees. Vt. samas: Turvavaatleja vastutusrikas töö viimasel rallil; Ivar Raidam: Lepiksoni panus autosporti oli tohutu; Hans H. Luik: Respect, Robert!

EVIDENCE FOR METAL ATTENUATION IN ACID MINE WATER BY SULFATE REDUCTION, PENN MINE, CALAVERAS COUNTY, CALIFORNIA

Science.gov (United States)

The Penn Mine in Calaveras County, California, produced Cu from massive sulfide ores from 1861 to 1953. Mine wastes were removed to a landfill during the late 1990s, improving surface-water quality, but deep mine workings were not remediated and contain metalliferous water with p...

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Science.gov (United States)

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

Genetics Home Reference: Roberts syndrome

Science.gov (United States)

... feet are located very close to the body (phocomelia). People with Roberts syndrome may also have abnormal ... may live into adulthood. A condition called SC phocomelia syndrome was originally thought to be distinct from ...

Tetra-amelia and splenogonadal fusion in Roberts syndrome

Energy Technology Data Exchange (ETDEWEB)

Ravel, T.J.L. de; Seftel, M.D.; Wright, C.A. [Univ. of the Witwatersrand, Johannesburg (South Africa)

1997-01-20

Roberts-SC phocomelia syndrome comprises limb deficiencies of variable severity, facial clefts, and other anomalies. Tetra-amelia may also be associated with facial clefts and similar anomalies. We report on a female infant with severe tetra-amelia, micrognathia, cleft palate, splenogonadal fusion, and premature centromere separation. We propose that this represents the severe expression of the Roberts-SC phocomelia syndrome. 18 refs., 6 figs.

Robert Lepiksoni maailm / Eha Komissarov

Index Scriptorium Estoniae

Komissarov, Eha, 1947-

2000-01-01

Näitus "Minu maailm. Robert Lepikson fotograafina ja kollektsionäärina" galeriis "Vaal". Väljas on loodusfotod, fotod autodest, kunstikogust Eduard Steinbergi (1937) ja Vladimir Nemuhhini (1925) maalid, paar Salvador Dali värvilist litograafiat

Remembering Robert Seydel

Directory of Open Access Journals (Sweden)

Lauren van Haaften­-Schick

2011-06-01

Full Text Available This January, while preparing a new course, Robert Seydel was struck and killed by an unexpected heart attack. He was a critically under-appreciated artist and one of the most beloved and admired professors at Hampshire College.At the time of his passing, Seydel was on the brink of a major artistic and career milestone. His Book of Ruth was being prepared for publication by Siglio Press. His publisher describes the book as: “an alchemical assemblage that composes the life of his alter ego, Ruth Greisman— spinster, Sunday painter, and friend to Joseph Cornell and Marcel Duchamp. Through collages, drawings, and journal entries from Ruth’s imagined life, Seydel invokes her interior world in novelistic rhythms.”This convergence of his professional triumph with the tragedy of his death makes now a particularly appropriate time to think about Robert Seydel and his work. This feature contains a selection of excerpts from Book of Ruth (courtesy of Siglio Press alongside a pair of texts remembering him and giving critical and biographical insights into his art and his person. These texts, from a former student and a colleague respectively, were originally prepared for Seydel's memorial at Hampshire College and have since been revised for publication in continent.

Roberts 22: a bipolar nebula with OH emission

International Nuclear Information System (INIS)

Allen, D.A.; Hyland, A.R.; Caswell, J.L.

1980-01-01

Roberts 22 is a bipolar reflection nebula illuminated by a hidden A2 Ie star. Most of its energy is radiated at infrared wavelengths. It also shows strong OH maser emission (OH 284.18 - 0.79) on the 1612 and 1665 MHz transitions, generally similar to the masers associated with M stars having infrared excesses. But the system contains no late-type star. This remarkable assemblage of attributes makes Roberts 22 unique; however, it is probably a key member of the newly-recognized population of bipolar nebulae. From an analysis of the properties of Roberts 22 some published interpretations of other bipolar nebulae are questioned, in particular the derivation of spectral types for their underlying stars by the assumption of photo-ionization of the gas, and their evolutionary description as proto-planetary nebulae. (author)

Spanish adaptation of The Penn State College of Medicine Scale to assess professionalism in medical students.

Science.gov (United States)

Bustamante, Eliseo; Sanabria, Álvaro

2014-01-01

Professionalism is a subject of interest in medical schools around the world. The use of a questionnaire could be useful to assess professionalism in Colombia. To adapt The Penn State University College of Medicine Professionalism Questionnaire as a culturally valid instrument in the Spanish language. We followed recommendations from the IQOLA project and used forward and back translation with four independent translations, as well as a pilot evaluation and an evaluation of psychometric features with 250 students. We evaluated item-scale correlations and internal consistency with Chronbach's alpha test and conducted a principal components factor analysis. Global Cronbach's alpha was 0.86, the Kaiser-Meyer-Olkin measure of sampling adequacy was 0.83, and Bartlett's test of sphericity had a p >0.00001. We found six factors that explained 93% of the total variance and four new factors emerged in the factor analysis, while eight items had high uniqueness. The Penn State University College of Medicine Scale measures professionalism attitudes in medical students with good reliability. However, the structure of the scale demonstrated differences when used in the Latin American medical student population.

Magnetohydrodynamics and the earth's core selected works by Paul Roberts

CERN Document Server

Soward, Andrew M

2003-01-01

Paul Roberts'' research contributions are remarkable in their diversity, depth and international appeal. Papers from the Paul Roberts'' Anniversary meeting at the University of Exeter are presented in this volume. Topics include geomagnetism and dynamos, fluid mechanics and MHD, superfluidity, mixed phase regions, mean field electrodynamics and the Earth''s inner core. An incisive commentary of the papers puts the work of Paul Roberts into historical context. Magnetohydrodynamics and the Earth''s Core provides a valuable source of reference for graduates and researchers working in this area of geoscience.

[Roberts-SC phocomelia syndrome].

Science.gov (United States)

Musfeld, D A; Bühler, E M; Heinzl, S

2001-01-01

The Roberts-SC phocomelia syndrome is a rare autosomal recessive inherited disorder clinically manifested by tetraphocomelia, pre- and postnatal growth retardation, and craniofacial abnormalities (skull, eyes, lip, and palate), accompanied at times by centromer puffing and splitting, renal abnormalities, heart defect, clitoral or penile enlargement, and bilateral corneal opacities. Mental retardation is common in surviving patients.

Max Weber and Robert Michels.

Science.gov (United States)

Scaff, Lawrence A.

1981-01-01

This paper investigates the unique intellectual partnership of Max Weber and Robert Michels, with particular emphasis on Weber's influence on Michel's inquiry into the sociology of parties and organization. Concludes with an evaluation of the import of Weber's critique of Michels' work. (DB)

Steven Hawking with Robert Aymar

CERN Multimedia

Maximilien Brice

2006-01-01

Steven Hawking is seen meeting with CERN's Director-General, Robert Aymar. Hawking visited CERN between 24 September and 1 October 2006. During his stay he gave two lectures and toured the LHC, which may provide insights into Hawking's most famous area of study, black holes.

Anthony ROBERTS 5 March 1948 – 16 January 2008

CERN Multimedia

TS Department

2008-01-01

We deeply regret to announce the death of Mr Anthony ROBERTS on 16 January 2008. Mr ROBERTS, born on 05.03.1948, worked in the HR Department and had been employed at CERN since 01.06.1973. The Director-General has sent his family a message of condolence on behalf of the CERN staff. Social Affairs Service Human Resources Department

The inauguration of Robert-Bourassa Park at James Bay

International Nuclear Information System (INIS)

Valiquette, M.

1997-01-01

Robert Bourassa's contributions to the hydroelectric development at James Bay were acknowledged with the inauguration of a park in the ex-prime minister's name. Phase 1 of the James Bay hydroelectric project constituted the world's biggest construction site, employing more than 180,000 people from beginning to project completion. The James Bay project allowed Hydro-Quebec to gain one of the world's largest electric power utilities and to gain significant competitive edge over its competitors. The Robert Bourassa Park contains a picnic area and a visitor interpretation centre which describes the history of the project. A sequence of 5 signposts summarize the contributions that Robert Bourassa made to the megaproject which cost over $20.6 billion. The complex consists of 65 turbines which produce 15,235 megawatts of electricity. 1 fig

Conferencias a la Memoria de la Dra. Lydia J. Roberts 1967, 1969-1973 (Conferences in Memory of Dr. Lydia J. Roberts 1967, 1969-1973).

Science.gov (United States)

Puerto Rico Univ., Rio Piedras.

This publication includes eleven lectures presented as part of a conference given honoring Dr. Lydia J. Roberts. Seven of the papers are written in the English language and four in Spanish. Most of the papers relate to the topic of nutrition, but a few pay tribute to Dr. Roberts in recognition of her distinguished leadership and teacher of human…

Robert Wilson's Invitation to Insanity.

Science.gov (United States)

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

DCU 250 Arabic dependency bank: an LFG gold standard resource for the Arabic Penn treebank

OpenAIRE

Al-Raheb, Yafa; Akrout, Amine; van Genabith, Josef; Dichy, J.

2006-01-01

This paper describes the construction of a dependency bank gold standard for Arabic, DCU 250 Arabic Dependency Bank (DCU 250), based on the Arabic Penn Treebank Corpus (ATB) (Bies and Maamouri, 2003; Maamouri and Bies, 2004) within the theoretical framework of Lexical Functional Grammar (LFG). For parsing and automatically extracting grammatical and lexical resources from treebanks, it is necessary to evaluate against established gold standard resources. Gold standards for various languages h...

Double trisomy (48,XXX,+18) with features of Roberts syndrome

Energy Technology Data Exchange (ETDEWEB)

Descartes, M.; Longshore, J.W.; Crawford, E. [Univ. of Alabama, Birmingham, AL (United States)] [and others

1994-09-01

We report an infant with double trisomy 48,XXX,+18, who also displayed features of Roberts syndrome. All previously published cases with similar double trisomy have presented with features of trisomy 18 syndrome. The chromosome analysis done at birth revealed the double trisomy; parental chromosomes were normal. The proband presented with microbrachycephaly, unilateral cleft lip and palate, choanal atresia, midfacial capillary hemanioma, thin nares, shallow orbits, malformed ears, sparse hair, hypomelia of the upper limbs, rocker-bottom feet, auricular septal defect and agenesis of the corpus callosum. Characteristic features of Roberts syndrome included hypomelia, midfacial defects, and severe growth deficiency. Among the many different features reported in the literature for patients with trisomy 18 syndrome, the most consistent were growth deficiency, clenched fingers and congenital heart defects (e.g. VSD, ASD, PDA). Although some of our patient`s features such as cleft lip and cleft palate, low-set malformed ears, ASD, defects of the corpus callosum, choanal atresia, radial aplasia could also be seen in trisomy 18 syndrome (in 10-50% of the cases), her phenotype was more typical of Roberts syndrome because of symmetrical hypomelia and midfacial defects. Our patient`s chromosomes did not show premature separation of centromeric heterochromatin, a feature reported to occur in approximately one-half of individuals with Roberts syndrome. Sporadic aneuploidy involving different chromosomes has been found in lymphocyte cultures from some Roberts syndrome patients and is considered by some authors as a mitotic mutant. This aneuploidy is most likely to be chromosome gain. The simultaneous occurrence of trisomy X and 18 is extremely rare with only 11 cases having been reported in the literature. Our patient is unique since she has the double trisomy in addition to the characteristic features of Roberts syndrome.

Robert Nemiroff: Communicating Astronomy 365 Days a Year

Science.gov (United States)

Pullen, L.; Russo, P.

2010-06-01

Few astronomy communication projects are as well known or as widely disseminated as the Astronomy Picture of the Day (or APOD for short). Since its creation in 1995, it has popularised thousands of images and helped to explain the cosmos through informative captions. Impressively, the site shows no signs of slowing down and has amassed many loyal supporters. This success can be attributed to the two astronomers behind the project: Robert Nemiroff and Jerry Bonnell. CAPjournal has interviewed Robert to discover his view of APOD, and the lesser known issues that surround it.

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Robert Koch was a German physician and scientist who made wide-ranging .... methods of bacterial staining so that bacteria could be visualized more easily and .... of whom became outstanding scientists in their own right, such as Friedrich.

Algebraic Methods in Plane Geometry

Indian Academy of Sciences (India)

Srimath

rally, a1 ;a2 ;a3 ;a4 m ust not all be 0.) If w e m ultiply all th e ai's by a non-zero constant w e get the sam e cubic. .... B ut a sm all m odi¯cation of the operation changes the ..... Robert Bix, Conics and Cubics: A Concrete Introduction to Algebraic ... Joseph H Silverman and John Torrence Tate, Rational Points on Elliptic.

Leaving Libertarianism: : Social Ties in Robert Nozick's New Philosophy

OpenAIRE

Herbjørnsrud, Dag

2002-01-01

SUMMARY This thesis Leaving Libertarianism: Social Ties in Robert Nozick s New Philosophy challenges the general and most widespread portrayals of the American philosopher Robert Nozick (1938-2002) by studying the notion of social ties in his later philosophy. The point of departure is the present descriptions of Nozick s philosophy. Mostly these depictions are based upon three postulates: That Nozick is an extreme individualist, that the libertarian Anarchy, State, and Utopia (1...

A Prospective Observational Study of Abdominal Injury Management in Contemporary Military Operations: Damage Control Laparotomy Is Associated With High Survivability and Low Rates of Fecal Diversion

Science.gov (United States)

2015-04-01

and rural application of the damage control philosophy. Mil Med. 2001;166:490–493. 12. Eiseman B, Moore EE, Meldrum DR, et al. Feasibility of damage...application of tranex- amic acid in trauma emergency resuscitation (MATTERs) study. Arch Surg. 2012;147:113–119. 70. Penn-Barwell JG, Roberts S

Roberts syndrome: clinical and cytogenetic aspects

OpenAIRE

Mann, N P; Fitzsimmons, J; Fitzsimmons, E; Cooke, P

1982-01-01

Roberts syndrome is reported in two sibs of consanguineous parents. Both infants had severe tetraphocomelia, facial clefting, and other serious malformations. In addition they were found to have an unusual cytogenetic abnormality with distortion of the normal sister chromatid relationship in many chromosomes.

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 9. The Timeless Legacy of Robert Koch - Founder of Medical Microbiology. Jaya S Tyagi. General Article Volume 11 Issue 9 September 2006 pp 20-28. Fulltext. Click here to view fulltext PDF. Permanent link:

The Question of Elitism: Some Movement to the Left?

Science.gov (United States)

Haack, Paul

1987-01-01

Calls for a synthesis of beneficial elitism and beneficial populism to ensure excellence for all. Suggests that Robert Penn Warren's views on how to collapse dualisms between these two philosophies provides the key to their synthesis. Concludes by comparing differences between elitism and populism and examining questions raised by Ralph Smith's…

Intrapartum diagnostic of Roberts syndrome - case presentation.

Science.gov (United States)

Socolov, Răzvan Vladimir; Andreescu, Nicoleta Ioana; Haliciu, Ana Maria; Gorduza, Eusebiu Vlad; Dumitrache, Florentin; Balan, Raluca Anca; Puiu, Maria; Dobrescu, Mihaela Amelia; Socolov, Demetra Gabriela

2015-01-01

Roberts syndrome is a rare disease, with multiple limb and skeletal abnormalities (called "pseudothalidomide disease"). There are only around 150 cases described in literature. We present a case of Roberts syndrome, diagnosed in moment of delivery, after a pregnancy without prenatal follow-up. The stillborn baby was naturally delivered by a 17-year-old primiparous woman at 38 weeks of amenorrhea. The pregnancy was not followed due to socioeconomic and family situation, and no prenatal ultrasound was performed. The male baby has 2650 g and presented several morphological abnormalities and tight double umbilical abdominal loop. The macroscopic evaluation showed: dolichocephaly, hypoplastic inferior maxilla with micrognathia, antimongoloid palpebral slant, pterygium colli, abnormal and lower implanted ears, superior limbs phocomelia, syndactyly at lower left limb and tetradactyly in all limbs, bilateral cryptorchidism, pancreatic aplasia. Roberts syndrome is a rare genetic disease with recessive autosomal transmission generated by mutations in ESCO2 gene, located on chromosome 8. The disease should be easy to diagnose by antenatal ultrasound examination, but in our case, the lack of prenatal follow-up determined the diagnostic at term. We believe consider this case is an argument towards introducing ultrasound-screening compulsory to all pregnancies. To identify a possible genetic mutation, further investigations of the parents are in progress, but classically the disease has a recessive autosomal transmission.

Robert Frost: Teacher "Earner, Learner, Yearner."

Science.gov (United States)

Vogel, Nancy Sue

An account of Robert Frost's teaching, along with an assessment of it, are presented. Material consulted includes Frost's published letters, prose, and poetry; Lawrance Thompson's authorized biography; Lesley Frost's "New Hampshire's Child: The Derry Journals of Lesley Frost;" and additional sources such as films and periodicals,…

The meanings of J. Robert Oppenheimer

CERN Document Server

Banco, Lindsey Michael

2016-01-01

He called the first atomic bomb “technically sweet,” yet as he watched its brilliant light explode over the New Mexico desert in 1945 in advance of the black horrors of Hiroshima and Nagasaki, he also thought of the line from the Hindu epic The Bhagavad Gita: “I am become Death, the destroyer of worlds.” Physicist J. Robert Oppenheimer, the scientific director of the Manhattan Project, the single most recognizable face of the atomic bomb, and a man whose name has become almost synonymous with Cold War American nuclear science, was and still is a conflicted, controversial figure who has come to represent an equally ambivalent technology. The Meanings of J. Robert Oppenheimer examines how he has been represented over the past seven decades in biographies, histories, fiction, comics, photographs, film, television, documentaries, theater, and museums. Lindsey Michael Banco gathers an unprecedented group of cultural texts and seeks to understand the multiple meanings Oppenheimer has held in American popul...

Kirjavahetus Kaarel Robert Pustaga / Karl Ast Rumor

Index Scriptorium Estoniae

Rumor, Karl, pseud., 1886-1971

2009-01-01

Kirjavahetus Rio de Janeiros elava Karl Ast Rumori ja New Yorgis elava Kaarel Robert Pusta vahel Eesti kongressi kokkukutsumise vajalikkuse, väliseesti ühingute ja nõukogude, ajakirjanduse ning üldise poliitilise olukorra teemadel

Stereoscopic CAD and Environmental Sculpture: Enhancement of the Design Process in the Visual Arts

Science.gov (United States)

Fisher, Robert N.; Bandini, Pier L.

1989-09-01

In this paper, co-authors Robert Fisher and Pier Luigi Bandini describe their personal observations concerning stereo enhancements of computer graphics images employed in their research. in Part One, Robert Fisher, a professional sculptor, Professor and Artist-in-Residence in the College of Engineering at Penn State, cites three recent environmental sculpture projects: "See-scape," "A Page from the Book of Skies," and an as yet untitled work. Wireframe images, interior views of architectural spaces, and complex imagery are rendered comprehensible by stereo 3-D. In Part Two, Pier L. Bandini, Associate Professor of Architecture and Director of the Architecture CAD Lab at Penn State, describes the virtues of the stereo-enhanced wireframe model--the benefits of the "see-through coupled with a complete awareness of the whole space." The final example, of a never-realized XVIII-century project, suggests a new and profound application of stereo 3-D to historical inquiry, namely, the experience of ancient spaces and structures that are no longer existing or that were never constructed.

Flow Visualization of Three-Dimensionality Inside the 12 cc Penn State Pulsatile Pediatric Ventricular Assist Device

OpenAIRE

Roszelle, Breigh N.; Deutsch, Steven; Manning, Keefe B.

2010-01-01

In order to aid the ongoing concern of limited organ availability for pediatric heart transplants, Penn State has continued development of a pulsatile Pediatric Ventricular Assist Device (PVAD). Initial studies of the PVAD observed an increase in thrombus formation due to differences in flow field physics when compared to adult sized devices, which included a higher degree of three-dimensionality. This unique flow field brings into question the use of 2D planar particle image velocimetry (PIV...

Lieutenant General Robert L. Bullard: Understanding Small and Large Conflicts

Science.gov (United States)

2012-12-06

Publishing, 1925). 11 Robert L. Bullard, American Soldiers Also Fought ( Garden City, NY: Longmens and Green, 1936). 12 Ibid., V. 13 Ibid., VI...2005, 41-45. 53 Robert L. Bullard, “Among the Savage Moros,” Metropolitan Magazine, vol. XXIV:III (June 1906), 264. 19 increased during his...59 Bullard, “Among the Savage Moros,” 264. 22 intuitively knew that if he was to assist a partner, help the deprived, or fight an adversary, he

Robert Putnam : miks peaksime naabritega rohkem rääkima? / Robert Putnam ; interv. Külli-Riin Tigasson

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

26. mail Tallinnas toimuva Avatud Ühiskonna Foorumi peaesineja, Harvardi Ülikooli professor väidab, et mida paremini tuntakse oma naabreid, mida aktiivsemalt osaletakse kohalikus elus ning mida rohkem inimesed omavahel suhtlevad, seda paremaks ja turvalisemaks muutub nende elukeskkond. Lisad: Robert Putnam (sünd 1941); Kuidas kasvatada sotsiaalset kapitali?

“Trickster” and “Republican”: Robert Harley’s Political Career in the 1690s

Directory of Open Access Journals (Sweden)

Kiselev Aleksandr

2014-12-01

Full Text Available Despite the fact that Robert Harley is known as Tory politician, he began his career as a Whig politician. His grandfather and father were Presbyterians, and Robert Harley himself was a Presbyterian during his entire life. Harley’s family supported the Glorious Revolution of 1688. In 1689 Robert Harley was first elected to the House of Commons as a representative of the Whig party. Thanks to his wife’s Foley family, Robert Harley was elected as a commissioner of public accounts in the House of Commons. In 1689 Britain entered the “war of King William” which was a burden for many gentry (Whigs or Tories. Robert Harley became famous in the parliament as a critic of the war and corruption in the army. In 1693 the Whig leaders headed the ministry and continued the war. Their policy divided the Whigs party in two factions: “Court Whigs” and “Country Whigs”. Robert Harley and his supporters became “Country Whigs”, and they criticized the “Court Whigs”. By 1700 Robert Harley joined the Tory party. The article also describes the evolution of historiography of Harley‘s policy. Victorian historians have called the Prime Minister a “stupid person”. The same opinion was repeated by Russian historians of the 19th century. But in the 20th century the assessment of Robert Harley’s activity was changed by the works of K. Feiling, G. Holmes, B.W. Hill and other historians. Soviet historians (for example M.A. Barg also called R.Harley a “mediocre politician”, but modern Russian historians (L.I. Ivonina, T.L. Labutina and others consider him a “clever statesman” and a “master of political intrigues and parliamentary diplomacy”.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First ...

African Journals Online (AJOL)

Tahir M. Malla

2015-07-14

/licenses/by-nc-nd/4.0/). 1. Introduction. Roberts SC phocomelia syndrome is an autosomal recessive developmental disorder characterized by pre and postnatal growth retardation, microcephaly, craniofacial anomalies,.

Roberts-SC phocomelia syndrome.

Science.gov (United States)

Maheshwari, A; Kumar, P; Dutta, S; Narang, A

2001-06-01

A severely growth retarded baby was born at 38 weeks gestation. He had multiple craniofacial anomalies, microbrachycephaly, phocomelia in the upper limbs and renal cysts visible on ultrasound. He died of recurrent apneas. The autopsy showed left sided multicystic dysplastic kidney and absence of one testis. Cytogenetic studies did not reveal any abnormality. The phenotypic features match those described in the Roberts-SC phocomelia syndrome. A literature review revealed that 50% of these patients have chromosomal defects and antenatal detection is possible on ultrasound and by chromosome analysis of the amniocytes.

Hemingway; A Collection of Critical Essays. Twentieth Century Views Series.

Science.gov (United States)

Weeks, Robert P., Ed.

One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Lillian Ross, Malcolm Crowley, E.M. Halliday, Harry Levin, Leslie Fiedler, D.H. Lawrence, Philip Young, Sean O'Faolain, Cleanth Brooks and Robert Penn Warren, Carlos Baker, Mark Spilka, Ray B. West, Jr., Nemi D'Agostino,…

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

Science.gov (United States)

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

Two autographs: Cecile Dewitt and Robert Hawking (for Steven Hawking)

Science.gov (United States)

Gaina, Alex

2007-12-01

Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.

Robert Knox, transcendentální anatomie a imaginace rasové války / Robert Knox, transcendental anatomy and imagination of racial war

Directory of Open Access Journals (Sweden)

Ivo Budil

2016-12-01

Full Text Available The main aim of the study is to emphasize the role and contribution of the Scottish physician and surgeon Robert Knox to the emergence and expansion of modern racial thinking and the concept of a racial war which became later influential as a result of the works of representatives of Social Darwinism. The main ideas outlined in the book The Races of Men: A Philosophical Enquiry into the Influence of Race over the Destinies of Nations, published by Robert Knox in 1850, will be analyzed in the historical and intellectual context of transcendental anatomy and Eurasian revolution.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

Directory of Open Access Journals (Sweden)

Tahir M. Malla

2016-01-01

Full Text Available There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conventional cytogenetic analysis of the case revealed premature sister chromatid separation. The premature centromeric separation was also confirmed by C banding analysis of the child. It is the first and the only case of Roberts SC phocomelia diagnosed from this part of the world. The present case report emphasizes the importance of conventional cytogenetics in the diagnosis of such syndromes.

THANK GOD FOR BOBBY: ROBERT KENNEDY AND THE CUBAN MISSILE CRISIS

Science.gov (United States)

2017-06-01

nomination and later confirmation of Robert Kennedy as United States Attorney General. The second was the failure of the Bay of Pigs operation in...Cuba. In nominating his brother, the President defied popular opinion and made a decision that would prove integral to his presidency. Although...and in place prior to the discovery of Soviet missiles in Cuba. Together, these two events gave Robert Kennedy a position from which to advise

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

OpenAIRE

Tahir M. Malla; Arshad A. Pandith; Fayaz A. Dar; Mahrukh H. Zargar

2016-01-01

There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister) chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conve...

Roberts-SC syndrome, a rare syndrome and cleft palate repair

Directory of Open Access Journals (Sweden)

Murthy Jyotsna

2008-01-01

Full Text Available Roberts SC syndrome is a rare syndrome with only 17 previously recognized patients reported in medical literature. The syndrome is characterized by multiple malformations, particularly, symmetrical limb reduction, craniofacial anomalies such as bilateral cleft lip and palate, micrognathia, and severe growth and mental retardation. Our patient, a young child of five years having Roberts-SC, was successfully operated for cleft palate under general anesthesia. The main features of the syndrome and the technical problems of anesthesia and surgery are discussed in this report.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography; J. Robert Oppenheimer. Die Biographie

Energy Technology Data Exchange (ETDEWEB)

Bird, Kai; Sherwin, Martin J.

2009-07-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [German] J. Robert Oppenheimer (1904-1967), der ''Vater der Atombombe'', zaehlt zu den schillerndsten Figuren der juengeren Zeitgeschichte. Fuer ihre glaenzende Biographie des ''amerikanischen Prometheus'' erhielten der Journalist Kai Bird und der Historiker Martin J. Sherwin den Pulitzer-Preis. Exemplarisch lassen sie das Drama eines Forschers lebendig werden, der sich zwischen Erkenntnisdrang und ethischer Verantwortung entscheiden muss. Oppenheimer leitete das streng geheime Manhattan-Projekt in der Wueste von New Mexico, wo am 16. Juli 1945 die erste Atombombe gezuendet wurde. Kurz darauf starben in Hiroshima und Nagasaki mehr als 200 000 Menschen durch die neue ''Wunderwaffe'' - die Menschheit war ins Atomzeitalter eingetreten. Erschuettert von der Zerstoerungskraft seiner Schoepfung, engagierte sich Oppenheimer fortan gegen den Einsatz nuklearer Waffen. Das machte ihn im Amerika der McCarthy-Aera verdaechtig. Er geriet ins Visier des FBI, wurde als Spion der Sowjetunion verleumdet und musste den Staatsdienst quittieren. Sein Privatleben wurde an die Oeffentlichkeit gezerrt, seine Wohnung verwanzt, sein Telefon abgehoert. Erst 1963 rehabilitierte ihn Praesident Kennedy. Ueber dreissig Jahre hinweg haben die Autoren Interviews mit Oppenheimers Angehoerigen, Freunden und Kollegen gefuehrt, FBI-Akten gesichtet, Tonbaender von Reden und Verhoeren

Education programs at Penn State Breazale Reactor - a focus on waste

International Nuclear Information System (INIS)

Davison, C.

1993-01-01

Discussions about energy policy and issues focus on environmental impact of energy production and the generation of waste. When dealing specifically with nuclear energy, one of the major concerns is the solution to the open-quotes waste problem.close quotes Since there is no repository in the US for the isolation of high-level radioactive waste generated by nuclear power plants, questions and criticism arise concerning this issue. Education is the key to providing information about this issue to help develop a more technologically literate society. Several educational programs and approaches will be discussed including: Penn State University's programs for students and teachers. The US DOE curriculum materials - open-quotes Science, Society and America's Nuclear Waste,close quotes the open-quotes International Workshop on Education in the field of Radioactive Waste Management - at the crossroad of energy, science and environment,close quotes and the American Nuclear Science Teacher's Association

Robert Aymar, Director-General of CERN

CERN Document Server

Patrice Loïez

2003-01-01

Robert Aymar, photographed in 2003 before taking his position as Director-General at CERN, succeeding Luciano Maiani in 2004. At this time, Aymar was director of the International Thermonuclear Experimental Reactor (ITER) although he had already been involved with developments at CERN, chairing the External Review Committee, set up in 2001 in response to the increased cost of the LHC.

The future of acoustics distance education at Penn State

Science.gov (United States)

Brooks, Karen P.; Sparrow, Victor W.; Atchley, Anthony A.

2005-04-01

For nearly 20 years Penn State's Graduate Program in Acoustics has offered a graduate distance education program, established in response to Department of Defense needs. Using satellite technology, courses provided synchronous classes incorporating one-way video and two-way audio. Advancements in technology allowed more sophisticated delivery systems to be considered and courses to be offered to employees of industry. Current technology utilizes real time video-streaming and archived lectures to enable individuals anywhere to access course materials. The evolution of technology, expansion of the geographic market and changing needs of the student, among other issues, require a new paradigm. This paradigm must consider issues such as faculty acceptance and questions facing all institutions with regard to blurring the distinction between residence and distance education. Who will be the students? What will be the purpose of education? Will it be to provide professional and/or research degrees? How will the Acoustics Program ensure it remains attractive to all students, while working within the boundaries and constraints of a major research university? This is a look at current practice and issues with an emphasis on those relevant to constructing the Acoustics Programs distance education strategy for the future.

Action des copolymères éthylène-acétate de vinyle sur la cinétique de nucléation et de croissance des n-paraffines n milieu hydrocarbure. Effect of Vinyl Ethyleneacetate Copolymers on the Nucleation and Growth Kinetics of N-Paraffins in a Hydrocarbon Medium.

Directory of Open Access Journals (Sweden)

Petinelli J. C.

2006-11-01

Full Text Available On cherche à mettre en évidence le mode d'action des copolymères éthylène-acétate de vinyle sur la cinétique de cristallisation des n-paraffines en milieu hydro-carbure. On s'attache, notamment, à déterminer si l'efficacité de ces additifs est peu ou prou influencée par le nombre de motifs non paraffiniques contenus dans leur chaîne.On décrit deux montages expérimentaux, l'un permettant d'étudier la cinétique de nucléation, l'autre la cinétique de croissance en solution. On observe, grâce à ces deux dispositifs, que la fréquence de germination tridimensionnelle et la vitesse de croissance des n-paraffines diminuent quand la concentration d'acétate de vinyle dans la solution augmente.On établit une relation entre le taux d'acétate de vinyle de la chaîne des copo-lymères et leur efficacité à retarder la cinétique de nucléation. La cinétique de croissance est discutée. On montre l'adsorption très forte de ces additifs sur les faces des cristaux et que le copolymère le plus riche en groupes acétate de vinyle est celui qui retarde le plus la cinétique de nucléation et de croissance des n- paraffines. An effort is made ta détermine how vinyl ethyleneacetate copolymers effect thé crystallization kinetics of n-paraffins in a hydrocarbon medium. In particular, research was done ta see if thé effectiveness of such additives is in thé least bit influenced by thé number of non-paraffinic patterns contained in their chain.Two expérimental assemblies are described, one for investigating nucléation kinetics, thé other growth kinetics in solution. These two devices are used ta observe thot thé theee-dimensional germination fréquency and growth rate of n-paraffins decrease as thé vinyl-acétate concentration in thé solution increases.A relationship is established between thé vinyl-acétate ratio of thé copolymer chain and thé effectiveness of thé copolymer in delaying thé nucléation kinetics. Growth kinetics

Esperienze estetiche nella quotidianità. Il caso delle tavole da skateboard: Damien Hirst e Supreme, Palace e Tate Britain

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Matilde Greci

2014-06-01

Full Text Available A reflection on the aesthetic status of some typical objects of everyday life, and the relationship we have with them, may originate from the development of “aesthetic experience” by John Dewey and Neopragmatism. The continuity between the common practices and aesthetic ones determines the significance of ordinary objects if they are linked to a project of enrichment and fulfillment of experience. A case that thematizes the richness of these practices in the contemporary world, and also the related theoretical and critical problems, is the production of skateboards. An established artist like Damien Hirst collaborates with the NYC-based streetwear brand Supreme; a new London-based brand, Palace Skateboards, and Tate realize together a few skateboard and a video.

Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

Science.gov (United States)

Rosmond, Tom

Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

Sea-Level Static Testing of the Penn State Two-Dimensional Rocket-Based Combined Cycle (RBCC) Testbed

Science.gov (United States)

Cramer, J. M.; Marshall, W. M.; Pal, S.; Santoro, R. J.

2003-01-01

Twin thruster tests have been conducted with the Penn State RBCC test article operating at sea- level static conditions. Significant differences were observed in the performance characteristics for two different thruster centerline spacings. Changing the thruster spacing from 2.50 to 1.75 in. reduced the entrained air velocity (-17%) and the thrust (-7%) for tests at a thruster chamber pressure of 200 psia and MR = 8. In addition, significant differences were seen in the static pressure profiles, the Raman spectroscopy profiles, and the acoustic power spectrum for these two configurations.

Robert Klopstock and Franz Kafka--the friends from Tatranské Matliare (the High Tatras).

Science.gov (United States)

Mydlík, M; Derzsiová, K

2007-01-01

The paper summarises the accessible literature on the life and work of well-known American lung surgeon, Professor Dr. Med. Robert Klopstock, who was in the years 1920-1924 a friend Franz Kafka. Professor Klopstock was of Hungarian origin and he got acquainted with Franz Kafka at the end of the year 1920 in Tatranské Matliare (The High Tatras). They were both patients treated for lung tuberculosis. They became close friends and their mutual correspondence shows their real friendship. Robert Klopstock was present at Franz Kafka's death-bed on June 3, 1924 in Kierling, near Klosterneuburg, not far from Vienna. Robert Klopstock studied at Medical Faculties of the Universities in Budapest, Prague, Kiel and Berlin. After his graduation in 1933 in Berlin, he worked as a lung surgeon at various surgical clinics and departments in Budapest and Berlin. In 1936 Robert Klopstock together with his wife visited the High Tatras and Tatranské Matliare. In 1937 Robert Klopstock with his wife Gizela, a writer and a translator, who translated the first chapters of Franz Kafka's novel "Trial" into Hungarian language, went to United States of America. During his stay in U.S.A. Dr. Med. Robert Klopstock was very active as a lung surgeon and a scientist. He published 64 specialized scientific papers, mostly in American medical journals. He became Professor of Lung Surgery at Downstate Medical Centre in New York-Brooklyn. He died on June 15, 1972 in New York.

Robert Aymar receives one of the highest Finnish distinctions

CERN Multimedia

2008-01-01

On 9 December 2008 Robert Aymar, CERN Director-General, was awarded the decoration of Commander, first class, of the Order of the Lion of Finland by the President of the Republic of Finland. This decoration, one of the highest of Finland, was presented in a ceremony by the Ambassador Hannu Himanen, Permanent Representative of Finland to the UN and other international organisations in Geneva. Robert Aymar was honoured for his service to CERN, the LHC, his role in the cooperation between Finland and CERN, as well as his contribution to science in general. In his speech the ambassador underlined CERN’s efforts in the field of education, mentioning the High school teachers programme.

Robert Eisenstein joins the ATLAS collaboration at CERN

CERN Multimedia

Maximilien Brice

2002-01-01

Robert Eisenstein, former assistant director for mathematical and physical sciences (MPS) at the US National Science Foundation (NSF), has stepped down from the job to spend a year at CERN as a member of the ATLAS collaboration.

Intervjuu American Wind Symphony Orchestra dirigendi Robert Austin Boudreau'ga = Interview with Mr. Robert Austin Boudreau, director of the American Wind Symphony Orchestra / Robert Austin Boudreau ; interv. Heli Ojamaa

Index Scriptorium Estoniae

Boudreau, Robert Austin

2007-01-01

11. IV 2007. a. tehtud telefoniintervjuu Robert A. Boudreau'ga, kellele arhitekt Louis I. Kahn disainis kontserdilaevad Point Counterpoint I (valmis 1961) ja Point Counterppoint II (kavandamist alustati 1966, valmis 1975). Louis I. Kahnist, koostööst arhitektiga ja laevadest. Selgitav kaaskiri arhitekt Heli Ojamaalt. Ill.: I laeva makett, II laeva joonised ja 4 värv. fotot

Robert Henry Thurston: Professionalism and Engineering Education

Science.gov (United States)

Nienkamp, Paul

2016-01-01

Robert Henry Thurston is presented in this article. He provides one the most significant examples of professionalizing engineering through innovative education and promoting scientific education practices in the late nineteenth century. The son of a draftsmen and steam engine mechanic, Thurston spent his early years in Providence, Rhode Island.…

La Corte Roberts e la questione della “preghiera municipale”

Directory of Open Access Journals (Sweden)

Adelaide Madera

2017-02-01

 The Roberts Court and the “municipal prayer” Abstract: In the USA, few topics are more divisive than the government’s use of religious expressions and symbols. The Supreme Court has tried to find a balance between the Establishment Clause of the U.S. Constitution and the inclusion of religious expressions in government activities. In Town of Greece v. Galloway, the Roberts Court upheld a town’s practice of opening board meetings with prayers from invited speakers. The essay critically examines the various opinions in the case, and looks at where this decision suggests the Establishment Clause doctrine is moving award.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography

International Nuclear Information System (INIS)

Bird, Kai; Sherwin, Martin J.

2009-01-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [de

Robert Lawson (?1846-1896).

Science.gov (United States)

Larner, A J; Gardner-Thorpe, C

2012-04-01

Various descriptions of what would now be called Korsakoff Syndrome may be found in the medical literature predating the eponymous reports of Sergei Korsakoff (1854-1900) that date from 1887 onwards. Of these, it has been stated that the "most promising account" (Draaisma in Disturbances of the mind 163-164, 2009) may be that of Dr. Robert Lawson, published in 1878 in the journal Brain in its inaugural year of publication (Lawson in Brain 1:182-194, 1878). As Lawson is likely to be an unfamiliar name to most neurologists, and does not appear in the Oxford Dictionary of National Biography, we offer this brief account of his life and work.

Displaying a Poster, Unifying a Campus: Undergraduate Research Day at Penn State Wilkes-Barre

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Jennie Levine Knies

2015-11-01

Full Text Available This article describes the first official Undergraduate Research Day at Penn State Wilkes-Barre, a small campus with approximately 550 undergraduate students and 8 four-year degree programs. In 2015, an informal planning committee, consisting of two librarians and two faculty members, embarked on a project to turn what had been an informal course assignment into a campus-wide research event.  By remaining flexible, engaged, and open to collaboration, the committee made Undergraduate Research Day in April 2015 a success, and plans are underway to hold this event in subsequent years.  The event energized and motivated students, faculty, and staff on campus and paved the way toward a unified organizational identity on campus.

75 FR 32740 - Action Affecting Export Privileges; Aaron Robert Henderson and Valhalla Tactical Supply

Science.gov (United States)

2010-06-09

... Robert Henderson and Valhalla Tactical Supply In the Matter of: Aaron Robert Henderson, 740 Jessie St., North Liberty, IA 52317. Respondent and Valhalla Tactical Supply, 740 Jessie Street, North Liberty, IA... is the owner, operator and president of Valhalla Tactical Supply (``Valhalla''), Valhalla is related...

Robert Rodrigueze verejugadega õudusfilm tuleb Igavuse planeedilt / Mihkel Raud

Index Scriptorium Estoniae

Raud, Mihkel, 1969-

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007. R. Rodrigueze filmist

Astronaut Robert L. Crippen prepares for underwater training session

Science.gov (United States)

1983-01-01

Astronaut Robert L. Crippen, STS-7 crew commander, adjusts his extravehicular mobility unit's (EMU) gloves prior to donning his helmet for a training session in the weightless environment test facility (WETF).

Das Fortbildungsangebot der Bibliothek des Robert Koch-Instituts: Dienstleistung im Publikationsprozess

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Senst, Henriette

2013-12-01

Full Text Available [english] Robert Koch-Institute’s scientists are supported during the publishing process in different ways. Relating to frequently asked questions the library offers trainings, which are integrated in the training program of the institute.How does a good literature research work? How do I manage my literature and how do I cite correctly? What do I have to consider during the publishing process? These and other questions are answered in trainings on literature research, managing bibliographies with EndNote and “Scientific Publishing in the Robert Koch-Institute” which take place regularly.

Expanding the mutation and clinical spectrum of Roberts syndrome.

Science.gov (United States)

Afifi, Hanan H; Abdel-Salam, Ghada M H; Eid, Maha M; Tosson, Angie M S; Shousha, Wafaa Gh; Abdel Azeem, Amira A; Farag, Mona K; Mehrez, Mennat I; Gaber, Khaled R

2016-07-01

Roberts syndrome and SC phocomelia syndrome are rare autosomal recessive genetic disorders representing the extremes of the spectrum of severity of the same condition, caused by mutations in ESCO2 gene. We report three new patients with Roberts syndrome from three unrelated consanguineous Egyptian families. All patients presented with growth retardation, mesomelic shortening of the limbs more in the upper than in the lower limbs and microcephaly. Patients were subjected to clinical, cytogenetic and radiologic examinations. Cytogenetic analysis showed the characteristic premature separation of centromeres and puffing of heterochromatic regions. Further, sequencing of the ESCO2 gene identified a novel mutation c.244_245dupCT (p.T83Pfs*20) in one family besides two previously reported mutations c.760_761insA (p.T254Nfs*27) and c.764_765delTT (p.F255Cfs*25). All mutations were in homozygous state, in exon 3. The severity of the mesomelic shortening of the limbs and craniofacial anomalies showed variability among patients. Interestingly, patient 1 had abnormal skin hypopigmentation. Serial fetal ultrasound examinations and measurements of long bones diagnosed two affected fetuses in two of the studied families. A literature review and case comparison was performed. In conclusion, we report a novel ESCO2 mutation and expand the clinical spectrum of Roberts syndrome. © 2015 Japanese Teratology Society.

Aitab hädaldamisest / Robert Antropov

Index Scriptorium Estoniae

Antropov, Robert, 1965-

2006-01-01

Endine politseijuht on seisukohal, et politseinike ja päästjate nappuses ei saa süüdistada ainult väikseid palku, küsimus on valikutes: kuidas ja millesse ressursse paigutada. Kalle Laanet ja Raivo Aeg vastavad küsimusele, mis on nende haldusalas konkreetselt kavas, et politsei saaks täita oma tegevusprioriteeti 100% ja tagada sisejulgeoleku. Vt. ka Robert Antropovi kommentaari 7. aug. Eesti Päevaleht lk. 2

Discovering Moral Engagement: An Interview with Robert Coles.

Science.gov (United States)

Scott, Bradwell D.

1995-01-01

Educator Robert Coles argues that there is a need for a basis on which to teach and cultivate moral awareness in parents and children. Active parenting requires both inner-directed and outer-directed focuses to take advantage of the everyday events through which morality is developed. (SLD)

Transitioning Natures: Robert Schuller’s Garden Grove Experiment

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Antonio Petrov

2016-09-01

Full Text Available Through the lens of Evangelist Reverend Robert H. Schuller’s Garden Grove drive-in walk-in church, this paper aims to exemplify how his architecture has transcended existing geographies that have long been anchored by the epistemology of what can be referred to as traditional “religious” architecture. This paper examines how Schuller instrumentalized broader imbrications of political contexts to change or manipulate the traditional religious subject. It also presents how Robert Schuller’s Garden Grove experiment reconceptualized “territory” as an evolving ideological dimension; not as a trajectory, or as transitory space, but as inhabitable third nature. My analysis challenges established readings of religious architecture as being interiorized manifestations. To do so, it poses the following questions: how does this meta-geographical dimension shed new light on questions of (traditional architectural aesthetics in Protestant architecture? What spaces and politics does it produce? Does the third nature have a history of its own?

Introduction : The scope of Robert Buijtenhuis' work

NARCIS (Netherlands)

Binsbergen, van W.M.J.; Konings, P.J.J.; Hesseling, G.S.C.M.; Konings, P.J.J.; Binsbergen, van W.M.J.; Hesseling, G.S.C.M.

2000-01-01

Cet ouvrage présente onze contributions rédigées par des africanistes qui ont collaboré étroitement avec l'anthropologue politique néerlandais Robert Buijtenhuijs et ont été influencés par ses travaux et sa personnalité. Le livre est un hommage à un auteur qui a été productif dans beaucoup de

Robert Sternberg's mental self-government theory and its ...

African Journals Online (AJOL)

Robert Sternberg's mental self-government theory and its contribution to our understanding of first-year distance learners' multiple thinking style preferences. ... This intelligence (the perception we have of information systems and the way we manage them) will influence the way we think and learn. This also applies to ...

Sir Robert Sidney’s Poems Revisited: the alternative sequence

OpenAIRE

Relvas, Maria de Jesus C.

1997-01-01

The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

Ravel and Robert-Houdin, Magicians

DEFF Research Database (Denmark)

Fillerup, Jessie

2013-01-01

,” which resonates with accounts of Ravel's Baudelairean artifice in life and work. For magicians, “illusion” was interchangeable with “effect.” The word “effect” recurs in both Ravel's writings and “The Philosophy of Composition,” a theoretical-didactic essay by Edgar Allan Poe, whom Ravel cited as one...... of his most important artistic influences. Ravel's appreciation of Poe has a much richer grain than has been imagined, extending beyond compositional artisanship to include literary and theatrical stratagems. Robert-Houdin, who started his career as a clockmaker, featured automata at his Soiréé...

Ruins in Reverse. An Exhibition at Tate Modern (March 1st - June 24th 2013

Directory of Open Access Journals (Sweden)

Colin Philip Sterling

2013-07-01

Full Text Available In the same week Ruins in Reverse opened at the Tate Modern gallery in London, Jonathan Jones asked on his Guardian Blog whether archaeology might be ‘the new art’ (2013. He posed this question as a result of two recent exhibitions at The British Museum, namely Ice Age Art and Life and Death in Pompeii and Herculaneum, both of which sought to emphasise the aesthetic qualities of archaeological objects. As Jones argued, such exhibitions ‘popularise’ the discipline by drawing attention to the ‘stupendous beauty of things that survive from the past’. While visitor numbers go some way to demonstrating the veracity of this comment, it seems restrictive both to art and to archaeology to frame any relationship between the two in this way. The spectacular archaeological find is atypical and potentially deceptive. A more potent line of enquiry - one adopted by several of the artists featured in Ruins in Reverse - might be to consider the present itself through an archaeological lens, applying the language of ‘discovery’ and ‘excavation’ to artefacts and locations that few would call stupendous or beautiful.

Quality of life research: interview with Professor Robert Cummins

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Robert Cummins

2013-09-01

Full Text Available Health-related quality of life (HRQOL is a fundamental concept in the field of clinical medicine and has been studied during the last years by psychologists, sociologists, economists and managers. The concept of HRQOL includes those aspects of overall QOL that can be indicated to have an impact on patients’ health, either physical or psychological. Concerning the individuals, this incorporates physical and mental health cognitions, including sociodemographic factors, sexual functioning, fatigue, sleep disorders and functional status. One of the most eminent experts in the world in the field of QOL is Prof. Robert Cummins [Professor of Psychology at Deakin University in Australia (School of Psychology, Deakin University, 221 Burwood Highway, Victoria 3125 Melbourne, Australia. E-mail: robert.cummins@deakin.edu.au] who kindly accepted to answer our questions in the con- text of this special edition.

Robert Schuman, principal architect of the European Union

NARCIS (Netherlands)

Margriet Krijtenburg

2015-01-01

A tangible proof of the meaning and scope of human flourishing that can change not only organizations but also entire societies, is given by Robert Schuman, the French Minister of Foreign Affairs who launched the Schuman Declaration (1950) that gave birth to the EU. His leitmotiv was to be a

Telecommunications Policy in the Caribbean: A Case Study of Telecommunications in Jamaica and Cuba

Science.gov (United States)

2013-03-01

sugar, cocoa , indigo, and coffee. The island’s export of agricultural products made the country a popular destination for English settlers. After...resources to support the country’s gross domestic product . “Out of Many, One People,” considered Jamaica’s national motto, adequately reflects the nation’s...large quantities of sugar and other agricultural products . Ironically, Robert Venables and William Penn were condemned to the Tower—the infamous

Research Ship Robert Gordon Sproul Underway Meteorological Data, Quality Controlled

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Robert Gordon Sproul Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and...

Zombilood / Robert Kirkman ; intervjueerinud Margit Tõnson, Peeter Helme

Index Scriptorium Estoniae

Kirkman, Robert

2010-01-01

Režissöör George A. Romero kultusfilmid zombidest "Elavate surnute öö", "Surnute koidik", "Surnute päev" jpt. on inspiratsiooniks koomiksikirjutaja Robert Kirklandile. Režissöör Frank Darabont on teinud tema tuntuimast koomiksiseeriast "The Walking Dead" teleseriaali "Kõndivad surnud". Zombiteema kasvavast populaarsusest ning intervjuu koomiksikirjutajaga

Education and Utopia: Robert Owen and Charles Fourier

Science.gov (United States)

Leopold, David

2011-01-01

The aims of education, and the appropriate means of realising them, are a recurring preoccupation of utopian authors. The utopian socialists Robert Owen (1771-1858) and Charles Fourier (1772-1837) both place human nature at the core of their educational views, and both see education as central to their wider objective of social and political…

Unusually Gothic : Robert Sigl's Laurin (1987)

OpenAIRE

Stiglegger, Marcus

2010-01-01

Marcus Stiglegger revives a lost Gothic treasure in this brief discussion of Robert Sigl's Laurin—a rare case of German genre film-making and the heir to FW Murnau's legacy. Phantastic genre cinema is very rare in contemporary Germany—especially in the 1980s, the time when Italian horror reached another peak with Dario Argento's Opera (1985). The cliché of the German "easy comedy" ruled mainstream film production at the time, and so it appeared a kind of miracle when 27-year-old writer/direct...

Architecture of (impossibilities: Robert Smithson's expositive spaces

Directory of Open Access Journals (Sweden)

Bráulio Romeiro

2012-06-01

Full Text Available This work investigates the North American artist Robert Smithson’s considerations on traditional expositive spaces: the museum and art gallery, as well as unusual and unexplored spaces by art up to that time. Looking through his texts we notice some enhanced perspectives and reset others, increasing limitation set on White Cube’s abstract and neutral quality and the substantiation on ideologies behind of these spaces manifestation.

Robert Hooke, 1635-1703.

Science.gov (United States)

Rowbury, Robin

2012-01-01

Robert Hooke was a polymath whose expertise during the 17th century spanned many different scientific areas. As a schoolboy on the Isle of Wight he was obsessed with the possibility of human flight and later became equally absorbed in cosmology and planetary motion. His skills as an artist were put to good use both as an architect following the Great Fire of London and before that in Micrographia. Although that book is best known for demonstrating the power of Hooke's microscope, Micrographia describes distant planetary bodies, the wave theory of light, the organic origin of fossils, and various other philosophical and scientific interests of its author The following thumbnail sketches of Hooke reveal him to be a man of enormous energy and imagination whose ideas were often pirated or under-rated.

‘Looking for Civilisation, Discovering Clark’: ‘Kenneth Clark – Looking for Civilisation’, An Exhibition at Tate Britain, 20 May – 10 August 2014

Directory of Open Access Journals (Sweden)

Matthew C Potter

2014-12-01

Full Text Available This review focuses upon the art historiographical lessons to be learned from the ‘Kenneth Clark – Looking for Civilisation’ exhibition at Tate Britain. It considers the challenges represented by art galleries choosing to present displays centred on art historians generally and Clark in particular. The political contexts that existed during Clark’s career and the recent exhibition are mapped in order to explore both how the actions of this democratic patriarch were motivated by his understanding of the shortcomings of humanist and Marxist ideologies, and how an opportunity for reassessment has presented itself since the declining dominance of the New Art History.

Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor

Science.gov (United States)

Ahmed, Mumtaz; Irshad, Ayesha

2015-01-01

The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

Ask! Your Library at the HUB: Penn State Libraries’ Experiences Providing Reference Services at the Campus Student Union Building

Directory of Open Access Journals (Sweden)

Anne Charlotte Behler

2008-06-01

Full Text Available The Web 2.0 generation presents many service challenges to libraries. College students of today have work styles that emphasize collaboration, preference for flexible and comfortable spaces, and independent discovery of information. Given that challenge, it is important for libraries to experiment with new and unique models of service. Librarians and Staff at the Penn State University Libraries explored offering library service at the main campus’s student union building during two trials, during the Spring and Fall semesters of 2006.

Investigations of groundwater system and simulation of regional groundwater flow for North Penn Area 7 Superfund site, Montgomery County, Pennsylvania

Science.gov (United States)

Senior, Lisa A.; Goode, Daniel J.

2013-01-01

Groundwater in the vicinity of several industrial facilities in Upper Gwynedd Township and vicinity, Montgomery County, in southeast Pennsylvania has been shown to be contaminated with volatile organic compounds (VOCs), the most common of which is the solvent trichloroethylene (TCE). The 2-square-mile area was placed on the National Priorities List as the North Penn Area 7 Superfund site by the U.S. Environmental Protection Agency (USEPA) in 1989. The U.S. Geological Survey (USGS) conducted geophysical logging, aquifer testing, and water-level monitoring, and measured streamflows in and near North Penn Area 7 from fall 2000 through fall 2006 in a technical assistance study for the USEPA to develop an understanding of the hydrogeologic framework in the area as part of the USEPA Remedial Investigation. In addition, the USGS developed a groundwater-flow computer model based on the hydrogeologic framework to simulate regional groundwater flow and to estimate directions of groundwater flow and pathways of groundwater contaminants. The study area is underlain by Triassic- and Jurassic-age sandstones and shales of the Lockatong Formation and Brunswick Group in the Mesozoic Newark Basin. Regionally, these rocks strike northeast and dip to the northwest. The sequence of rocks form a fractured-sedimentary-rock aquifer that acts as a set of confined to partially confined layers of differing permeabilities. Depth to competent bedrock typically is less than 20 ft below land surface. The aquifer layers are recharged locally by precipitation and discharge locally to streams. The general configuration of the potentiometric surface in the aquifer is similar to topography, except in areas affected by pumping. The headwaters of Wissahickon Creek are nearby, and the stream flows southwest, parallel to strike, to bisect North Penn Area 7. Groundwater is pumped in the vicinity of North Penn Area 7 for industrial use, public supply, and residential supply. Results of field investigations

The auriferous placer at Mount Robert, Pietersburg Greenstone belt

International Nuclear Information System (INIS)

Saager, R.; Muff, R.

1986-01-01

The Mount Robert gold placer near Potgietersrus occurs in coarse, matrix-supported conglomerates of the Uitkyk Formation within the Pietersburg greenstone belt. Sedimentological and mineralogical investigations indicate that the conglomerates and the ore minerals were derived from a greenstone provenance, and that they were deposited in a braided river environment within a rapidly subsiding trough. Lack of sedimentological concentration of the heavy minerals is considered to be the main reason for the low and erratic gold grades encountered (usually below 1 g/t) and, thus, the failure of all past mining ventures. The mineralogical composition of the Mount Robert ore closely resembles that of the Witwatersrand deposits. However, uraninite is absent, probably as a result of its complete removal by weathering processes. Remaining small uranium concentrations can still be detected within the conglomerates where they occur associated with grains of carbonaceous matter, leucoxene aggregates, and secondary iron-hydroxides. U3O8 values found in the conglomerates are given

TBT recommends : Vera Bila. The No Smoking Orchestra. Robert Plant

Index Scriptorium Estoniae

2005-01-01

Mustlasansambli Kale ja Vera Bila kontserdist 8. apr Tallinnas. Bosnia filmirežissööri Emir Kusturica ja tema ansambli No Smoking Orchestra kontserdist 12. apr. Riias. Inglise rocklaulja Robert Planti kontserdist 10. apr. Vilniuses

Kventin Tarantino + Robert Rodriges = Grainhaus, ili Kinonostalgija po-amerikanski / Andrei Sozinov

Index Scriptorium Estoniae

Sozinov, Andrei

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007

The Guatemala-Penn Partners: An Innovative Inter-Institutional Model for Scientific Capacity-Building, Healthcare Education, and Public Health

Science.gov (United States)

Paniagua-Avila, Maria Alejandra; Messenger, Elizabeth; Nelson, Caroline A.; Calgua, Erwin; Barg, Frances K.; Bream, Kent W.; Compher, Charlene; Dean, Anthony J.; Martinez-Siekavizza, Sergio; Puac-Polanco, Victor; Richmond, Therese S.; Roth, Rudolf R.; Branas, Charles C.

2017-01-01

Population health outcomes are directly related to robust public health programs, access to basic health services, and a well-trained health-care workforce. Effective health services need to systematically identify solutions, scientifically test these solutions, and share generated knowledge. The World Health Organization (WHO)’s Global Healthcare Workforce Alliance states that the capacity to perform research is an essential factor for well-functioning public health systems. Low- and middle-income countries have greater health-care worker shortages and lower research capacity than higher-income countries. International global health partnerships between higher-income countries and low-middle-income countries aim to directly address such inequalities through capacity building, a process by which human and institutional resources are strengthened and developed, allowing them to perform high-level functions, solve complex problems, and achieve important objectives. The Guatemala–Penn Partners (GPP) is a collaboration among academic centers in Guatemala and the University of Pennsylvania (Penn), in Philadelphia, Pennsylvania that echoes the vision of the WHO’s Global Healthcare Workforce Alliance. This article describes the historical development and present organization of the GPP according to its three guiding principles: university-to-university connections, dual autonomies with locally led capacity building, and mutually beneficial exchanges. It describes the GPP activities within the domains of science, health-care education, and public health, emphasizing implementation factors, such as sustainability and scalability, in relation to the guiding principles. Successes and limitations of this innovative model are also analyzed in the hope that the lessons learned may be applied to similar partnerships across the globe. PMID:28443274

De 'wraak van de geografie' volgens Robert D. Kaplan

NARCIS (Netherlands)

Mamadouh, V.

2013-01-01

De Amerikaanse publicist Robert D. Kaplan heeft een nieuwe bestseller, De wraak van de geografie, waarin hij het belang van geografie voor de internationale politiek uit de doeken doet. Zijn roep om meer aandacht voor geografie is echter erg eenzijdig en een miskenning van alles waar ons vak voor

A New Coherent Science Content Storyline Astronomy Course for Pre-Service Teachers at Penn State

Science.gov (United States)

Palma, Christopher; Plummer, Julia; Earth and Space Science Partnership

2016-01-01

The Earth and Space Science Partnership (ESSP) is a collaboration among Penn State scientists, science educators and seven school districts across Pennsylvania. One of the ESSP goals has been to provide pre-service teachers with new or improved science course offerings at Penn State in the Earth and Space Science domains. In particular, we aim to provide students with opportunities to learn astronomy content knowledge through teaching methods that engage them in investigations where they experience the practices used by astronomers. We have designed a new course that builds on our research into students' ideas about Solar System astronomy (Plummer et al. 2015) and the curriculum our team created for a professional development workshop for in-service teachers (Palma et al. 2013) with this same theme. The course was offered for the first time in the spring 2015 semester. We designed the course using a coherent science content storyline approach (see, e.g., Palma et al. 2014), which requires all of the student investigations to build towards a big idea in science; in this case, we chose the model for formation of our Solar System. The course led pre-service teachers through a series of investigations that model the type of instruction we hope they will adopt in their own classrooms. They were presented with a series of research questions that all tie in to the big idea of Solar System formation, and they were responsible for collecting and interpreting their own data to draw evidence-based conclusions about one aspect of this model. Students in the course were assessed on their astronomy content knowledge, but also on their ability to construct arguments using scientific reasoning to answer astronomy questions. In this poster, we will present descriptions of the investigations, the assessments used, and our preliminary results about how the course led this group of pre-service teachers to improved understanding of astronomy content and the practices astronomers use in

Antes de los Estudios Culturales. Robert Warshow y la experiencia

Directory of Open Access Journals (Sweden)

Antonio Lastra

2008-01-01

Full Text Available Este artículo estudia la influencia del concepto de experiencia que desarrolla Robert Warshow. Warshow ha supuesto el contrapunto americano a las teorías desarrolladas por Walter Benjamien en Europa. Si bien ambos insistieron en la pobreza de la experiencia, como resultado de la tecnificación de la sociedad, Warshow supo introducir matizaciones que influyeron en todo el círculo de intelectuales concentrados en Nueva York durante la etapa de consolidación de los Estudios Culturales. This paper studies the influence of the experience concept by Robert Warshow. Warshow is the American counterpoint to theories developed by Walter Benjamin in Europe. Although both insisted in the poverty of experience, as a result of technique, Warshow knew how to introduce nuances that influenced intellectuals in New York as Cultural Studies emerged.

Improvement on The Ellis and Roberts Viability Model

Directory of Open Access Journals (Sweden)

Guoyan Zhou

2016-05-01

Full Text Available With data sets of germination percent and storage time of seed lot of wheat and sorghum stored at three different storage temperature(t, °C with three different water content (m, % of seeds, together with data set of buckwheat and lettuce reported in literatures, the possibility that seed survival curve were transformed into line by survival proportion and the relationship that logarithm of average viability period (logp50 and standard deviation of seed death distribution in time (δwith t, m and interaction between t and m were analysed. Result indicated that survival proportion transformed seed survival curve to line were much easier than the probability adopted by Ellis and Roberts, and the most important factor affecting logp50 and δ of seed lot was interaction between t and m. Thus, Ellis and Roberts viability model were suggested to be improved as Ki=Vi-p/10K-CWT (t×m to predict longevity of seed lot with initial germination percent unknown, a new model of Gi/G0=A-P/10K-CWT(t×m was constructed to predict longevity of seed lot with initial germination percent already known.

Percy Julian, Robert Robinson, and the Identity of Eserethole

Science.gov (United States)

Ault, Addison

2008-01-01

The Nova production "Percy Julian--Forgotten Genius" included the very public disagreement between Percy Julian, an unknown American chemist, and Robert Robinson, possibly the best known organic chemist of the day, as to the identity of "eserethole", the key intermediate for the synthesis of the alkaloid physostigmine. The Nova production,…

John Bingham Roberts and the first American monograph on human brain surgery.

Science.gov (United States)

Stone, J L

2001-10-01

JOHN BINGHAM ROBERTS (1852-1924) of Philadelphia was an active general surgeon in the latter 19th and early 20th centuries. He made pioneering contributions to a number of areas of surgery. From 1880 until the end of his career, he was one of the few American surgeons to advocate an aggressive exploratory approach to cranial fractures in an effort to avoid consequences such as infection, delayed seizures, and insanity. In his 1885 article in the Transactions of the American Surgical Association titled "The Field and Limitation of the Operative Surgery of the Human Brain," he predicted that with antiseptic precautions and the growing knowledge of cerebral localization, operations on the brain would become commonplace. This work predated that of Horsley, Keen, and many others. Roberts had a continuing interest in head injuries, cranial fractures, and the development of trephines and burrs for reconstructive cranial work, but his active enthusiasm for brain surgery diminished in the 1890s. Nevertheless, Roberts was a very prolific teacher and leader in American surgery who is perhaps best remembered for his monographs and textbooks on general, orthopedic, plastic, and reconstructive surgery.

FEASIBILITY ANALYSIS FOR INSTALLING A CIRCULATING FLUIDIZED BED BOILER FOR COFIRING MULTIPLE BIOFUELS AND OTHER WASTES WITH COAL AT PENN STATE UNIVERSITY

Energy Technology Data Exchange (ETDEWEB)

Bruce G. Miller; Sharon Falcone Miller; Robert Cooper; John Gaudlip; Matthew Lapinsky; Rhett McLaren; William Serencsits; Neil Raskin; Tom Steitz; Joseph J. Battista

2003-03-26

The Pennsylvania State University, utilizing funds furnished by the U.S. Department of Energy's Biomass Power Program, investigated the installation of a state-of-the-art circulating fluidized bed boiler at Penn State's University Park campus for cofiring multiple biofuels and other wastes with coal, and developing a test program to evaluate cofiring biofuels and coal-based feedstocks. The study was performed using a team that included personnel from Penn State's Energy Institute, Office of Physical Plant, and College of Agricultural Sciences; Foster Wheeler Energy Services, Inc.; Foster Wheeler Energy Corporation; Parsons Energy and Chemicals Group, Inc.; and Cofiring Alternatives. The activities included assessing potential feedstocks at the University Park campus and surrounding region with an emphasis on biomass materials, collecting and analyzing potential feedstocks, assessing agglomeration, deposition, and corrosion tendencies, identifying the optimum location for the boiler system through an internal site selection process, performing a three circulating fluidized bed (CFB) boiler design and a 15-year boiler plant transition plan, determining the costs associated with installing the boiler system, developing a preliminary test program, determining the associated costs for the test program, and exploring potential emissions credits when using the biomass CFB boiler.

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE

Directory of Open Access Journals (Sweden)

M. Pourissa

2003-07-01

Full Text Available The Robert/SC (pseudothalidomide syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects and craniofacial abnormalities is reported whose diabetic mother took mebendazole and glibenclamide in early pregnancy. Ultrasonographic findings of syndromes with phocomelia are discussed as well as Robert/SC syndrome which is the most probable diagnosis. Robert/SC phocomelia syndrome is a rare autosomal recessive condition characterized by severe pre and postnatal growth deficiency, symmetric limb reductions of variable severity and craniofacial anomalies including hypertelorism, hypoplastic nasal alae, cleft lip and palate. About half of the reported cases presented chromosomal abnormalities. We think that findings in our case are consistent with Robert/SC syndrome with additional abnormalities.

78 FR 12357 - Brockway Mould, Inc., a Division of Ross International Ltd. Including Robert Lerch From BJR...

Science.gov (United States)

2013-02-22

... Division of Ross International Ltd. Including Robert Lerch From BJR Trucking, Brockport, PA; Amended..., applicable to workers and former workers of Brockway Mould, Inc., a division of Ross International Ltd... Brockway Mould, Inc., a division of Ross International Ltd., including Robert Lerch from BJR Trucking...

Robert Aymar seals the last interconnect in the LHC

CERN Multimedia

Maximilien Brice

2007-01-01

The LHC completes the circle. On 7 November, in a brief ceremony in the LHC tunnel, CERN Director General Robert Aymar (Photo 1) sealed the last interconnect between the main magnets of the Large Hadron Collider (LHC). Jean-Philippe Tock, leader of the Interconnections team, tightens the last bolt (Photos 4-8).

Robert Nozick's entitlement theory of justice: a critique | Nnajiofor ...

African Journals Online (AJOL)

The burden of this paper is to critique Robert Nozick's entitlement theory of justice which was drafted as an argument against traditional distribution theories. Nozick's theory of justice claims that whether a distribution is just or not depend entirely on how it came about. By contrast, justice according to equality, need, desert or ...

The strange trial of Robert Oppenheimer; L'etrange proces de Robert Oppenheimer

Energy Technology Data Exchange (ETDEWEB)

Kevles, D.J. [Yale Univ., New Haven, CT (United States); Institut de Technologie de Californie (United States)

2004-04-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Robert Spitzer and psychiatric classification: technical challenges and ethical dilemmas.

Science.gov (United States)

Jacob, K S

2016-01-01

Dr Robert Leopold Spitzer (May 22, 1932-December 25, 2015), the architect of modern psychiatric diagnostic criteria and classification, died recently at the age of 83 in Seattle. Under his leadership, the American Psychiatric Association's (APA) Diagnostic and Statistical Manuals (DSM) became the international standard.

Wikinews interviews World Wide Web co-inventor Robert Cailliau

CERN Multimedia

2007-01-01

"The name Robert Caillau may not ring a bell to the general pbulic, but his invention is the reason why you are reading this: Dr. Cailliau together with his colleague Sir Tim Berners-Lee invented the World Wide Web, making the internet accessible so it could grow from an academic tool to a mass communication medium." (9 pages)

Three-Index Symmetric Matter Representations of SU(2) in F-Theory from Non-Tate Form Weierstrass Models

CERN Document Server

Klevers, Denis

2016-01-01

We give an explicit construction of a class of F-theory models with matter in the three-index symmetric (4) representation of SU(2). This matter is realized at codimension two loci in the F-theory base where the divisor carrying the gauge group is singular; the associated Weierstrass model does not have the form associated with a generic SU(2) Tate model. For 6D theories, the matter is localized at a triple point singularity of arithmetic genus g=3 in the curve supporting the SU(2) group. This is the first explicit realization of matter in F-theory in a representation corresponding to a genus contribution greater than one. The construction is realized by "unHiggsing" a model with a U(1) gauge factor under which there is matter with charge q=3. The resulting SU(2) models can be further unHiggsed to realize non-Abelian G_2xSU(2) models with more conventional matter content or SU(2)^3 models with trifundamental matter. The U(1) models used as the basis for this construction do not seem to have a Weierstrass real...

Conceptualising Childhood: Robert Louis Stevenson's "A Child's Garden of Verses."

Science.gov (United States)

Webb, Jean

2002-01-01

Discusses the construct of childhood in Robert Louis Stevenson's collection of poems, "A Child's Garden of Verses," by employing notions of child development drawn from Jean Piaget and Lev Vygotsky. Finds, from a literary perspective, Stevenson's collection located on the boundaries of romanticism and modernism. (BT)

75 FR 53861 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Science.gov (United States)

2010-09-02

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1...). ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all Robert E. Rust... CFR part 39) to include an AD that would apply to all Robert E. Rust, Jr. Models DeHavilland DH.C1...

Robert Lacoste's the darker side practical applications for electronic design concepts from circuit cellar

CERN Document Server

Lacoste, Robert

2009-01-01

Robert Lacoste's The Darker Side column has quickly become a must read among Circuit Cellar devotees. His column provides readers with succinct theoretical concepts and practical applications on topics as far reaching as digital modulation to antenna basics. Difficult concepts are demystified as Robert shines a light on complex topics within electronic design.This book collects sixteen Darker Side articles that have been enriched with new, exclusive content from the author. An intro into The Darker Side will give examples of material that can enhance and optimize the way you design. A

Sprawl: A Compact History (Author: Robert Bruegmann)

OpenAIRE

Hayter, Jason Alexander

2006-01-01

Search a well-stocked library or bookstore for works on urban form and you might reach the same conclusion drawn by Robert Bruegmann: "Most of what has been written about sprawl to date has been written about com­ plaints" (p. 3). But what separates Bruegmann, a professor of art history, architecture, and urban planning at the University of Illinois at Chicago, from most people is what he does next. "[S]o many 'right-minded' people were so vociferous on the subject that I began to suspect tha...

Invited commentary on 'Robert G Edwards and the Roman Catholic Church'.

Science.gov (United States)

Head, Ivan Francis

2011-06-01

In this issue of Reproductive BioMedicine Online, Benagiano, Carrara and Filippi have produced a clearly written and comprehensive account of why the Roman Catholic Church has not welcomed the award of the 2010 Nobel Prize in Physiology and Medicine to Dr Robert G Edwards for the development of human IVF. I commend the article for its clarity and lucidity but attempt to point out some areas where disagreement even with its nuanced opposition to IVF may be legitimate. I try to make some simple comments that explain why this is so and I suggest some areas to which contemporary theology and philosophy can commit itself. But it is good to see even a nuanced response to the work of Robert G Edwards rather than a blanket condemnation. Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Introduction : L'étendue des travaux de Robert Buijtenhuis

NARCIS (Netherlands)

Binsbergen, van W.M.J.; Konings, P.J.J.; Binsbergen, van W.M.J.; Hesseling, G.S.C.M.

2000-01-01

Cet ouvrage présente onze contributions rédigées par des africanistes qui ont collaboré étroitement avec l'anthropologue politique néerlandais Robert Buijtenhuijs et ont été influencés par ses travaux et sa personnalité. Le livre est un hommage à un auteur qui a été productif dans beaucoup de

Robert J. Aumann - matemaatikust Nobeli preemia laureaat / Peeter Puusemp

Index Scriptorium Estoniae

Puusemp, Peeter, 1947-

2006-01-01

2005. a. Nobeli preemia majanduse alal silmapaistva panuse eest mänguteooria ülesannete lahendamisse saanud Robert J. Aumannist ja D. Saari loetelu matemaatikutest - Nobeli preemia laureaatidest: John Nash'ist, Herbert Hauptman'ist, John Pople'ist, Bertrand Arthur William Russell'ist, Kenneth Joseph Arrow'ist, Gerard Debreu'ist, Leonid Vitaljevitš Kantorovitš'ist, Reinhard Selten'ist, Jan Tinbergen'ist

Kablilt Casablancasse : Eesti suurim seikleja John Robert Ignace Lepp 100 / Vello Salo

Index Scriptorium Estoniae

Salo, Vello, 1925-

2009-01-01

Eesti päritolu seikleja John Robert Lepp, Prantsusmaal tuntud kui katoliku kiriku preester Ignace Lepp, avaldas prantsuse ja saksa keeles hulgaliselt raamatuid psühholoogia, filosoofia ja religiooni valdkonnast

Underwater EVA training in the WETF with astronaut Robert L. Stewart

Science.gov (United States)

1983-01-01

Underwater extravehicular activity (EVA) training in the weightless environment training facility (WETF) with astronaut Robert L. Stewart. Stewart is simulating a planned EVA using the mobile foot restraint device and a one-G version of the Canadian-built remote manipulator system.

A Pedagogy of Sight: Microscopic Vision in Robert Hooke's "Micrographia"

Science.gov (United States)

Jack, Jordynn

2009-01-01

Robert Hooke's "Micrographia" (1665) holds an important place in the history of scientific visual rhetoric. Hooke's accomplishment lies not only in a stunning array of engravings, but also in a "pedagogy of sight"--a rhetorical framework that instructs readers how to view images in accordance with an ideological or epistemic program. Hooke not…

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

[Robert Koch was right. Towards a new interpretation of tuberculin therapy].

Science.gov (United States)

Cardona, Pere J

2006-01-01

At the centenary of Robert Koch's Nobel Prize award, tuberculosis treatment with tuberculin, which was announced in Berlin in 1890, is still considered a failure. Nevertheless, there is now sufficient information supporting the idea that tuberculin therapy was widely used until the second half of the twentieth century; thus, the impact of this treatment should be studied and related to the decrease in tuberculosis-related mortality recorded in that period. Moreover, tuberculin therapy has inspired at least two new immunotherapies; these, however, were directed toward precisely the opposite effect: suppression of the Koch phenomenon. Thus, inoculation of Mycobacterium vaccae polarizes the immune response towards the Th1 type; and inoculation of RUTI avoids local immunodepression after short-term chemotherapy without inducing toxicity. For this reason, Robert Koch's work on antituberculosis therapy should be reread and proper recognition given to his contribution in this field.

Doctor Julius Robert Mayer and Energy Processes in Living Systems

Science.gov (United States)

Erlichson, Herman

2007-01-01

The overwhelming majority of important papers in physics are written by physicists. But the physician Julius Robert Mayer (1814-1878, see photo) did a valid theoretical calculation of the mechanical equivalent of heat just before Joule reported on his results from his well-known paddle-wheel experiments. Joule is well-known to physics people and…

ROBERT autonomous navigation robot with artificial vision

International Nuclear Information System (INIS)

Cipollini, A.; Meo, G.B.; Nanni, V.; Rossi, L.; Taraglio, S.; Ferjancic, C.

1993-01-01

This work, a joint research between ENEA (the Italian National Agency for Energy, New Technologies and the Environment) and DIGlTAL, presents the layout of the ROBERT project, ROBot with Environmental Recognizing Tools, under development in ENEA laboratories. This project aims at the development of an autonomous mobile vehicle able to navigate in a known indoor environment through the use of artificial vision. The general architecture of the robot is shown together with the data and control flow among the various subsystems. Also the inner structure of the latter complete with the functionalities are given in detail

Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

Science.gov (United States)

Lundquist, Arlene J.; Nash, Robert

1988-01-01

Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

Penn West Energy Trust CO{sub 2} EOR storage monitoring project

Energy Technology Data Exchange (ETDEWEB)

Chalaturnyk, R. [Alberta Univ., Edmonton, AB (Canada)

2007-07-01

This presentation described Penn West Energy Trust's carbon dioxide (CO{sub 2}) enhanced oil recovery (EOR) storage monitoring project. The project formed part of a royalty credit program that offered a royalty reduction to energy companies as part of a plan to encourage the development of a CO{sub 2} storage industry in Alberta. The multi-agency project is expected to provide a better understanding of the fate of CO{sub 2} injected into petroleum reservoirs and the role that CO{sub 2} storage will play in reducing greenhouse gas (GHG) emissions. The project is located in a reservoir that had previously been waterflooded. High purity CO{sub 2} is injected through 2 directional wells. Data acquired from the field is used to provide information on baseline geology and hydrogeology, as well as to provide details of baseline leakages. Rock properties are investigated in order identify issues affecting rock strength. Geophysical monitoring is conducted to interpret baseline seismic profile datasets as well as to integrate active and passive survey analyses with geochemical characterization studies and reservoir models. The project is currently in the stage of developing a simulation model based on a comprehensive understanding of CO{sub 2} injection mechanisms. The model will be used to predict CO{sub 2} storage capacity and movement. refs., tabs., figs.

Kollaaž ja kontekst. Robert Rumase liiklusmärgid Tallinnas / Hanno Soans

Index Scriptorium Estoniae

Soans, Hanno, 1974-

2004-01-01

Sekkuv kunst. Poola kunstniku Robert Rumase (1966) rahvusvahelisest kunstiprojektist "Linnamanöövrid", Kai Kaljo videost "One way to see America", Krzysztof Wodicko "Kodutute projektsioonist" ja New York City Unioni väljaku ümberkorraldamisest

Must, valge + hall : Sam Wagstaffi ja Robert Mapplethorpe'i portree / Madis Palm

Index Scriptorium Estoniae

Palm, Madis

2008-01-01

Dokumentaalfilm "Black, White & Gray: Sam Wagstaff and Robert Mapplethorpe" : autor ja režissöör James Crump : Ameerika Ühendriigid 2007. Filmi näidati filminädala "Art in America" raames Tallinnas

Drawings of fossils by Robert Hooke and Richard Waller

Science.gov (United States)

Kusukawa, Sachiko

2013-01-01

The drawings of fossils by Robert Hooke and Richard Waller that were the basis of the engravings in Hooke's Posthumous works (1705) are published here for the first time. The drawings show that both Hooke and Waller were proficient draftsmen with a keen eye for the details of petrified objects. These drawings provided Hooke with a polemic edge in making the case for the organic origins of ‘figured stones’.

Lydia J. Roberts's Nutrition Research and the Rhetoric of "Democratic" Science

Science.gov (United States)

Jack, Jordynn

2009-01-01

This article examines nutritionist Lydia J. Roberts's use of the "democratic approach" as a rhetorical strategy both to build solidarity among scientists and to enact participatory research in a rural Puerto Rican community. This example suggests that participatory scientific methodologies are not necessarily democratic but may function…

Development of abbreviated eight-item form of the Penn Verbal Reasoning Test.

Science.gov (United States)

Bilker, Warren B; Wierzbicki, Michael R; Brensinger, Colleen M; Gur, Raquel E; Gur, Ruben C

2014-12-01

The ability to reason with language is a highly valued cognitive capacity that correlates with IQ measures and is sensitive to damage in language areas. The Penn Verbal Reasoning Test (PVRT) is a 29-item computerized test for measuring abstract analogical reasoning abilities using language. The full test can take over half an hour to administer, which limits its applicability in large-scale studies. We previously described a procedure for abbreviating a clinical rating scale and a modified procedure for reducing tests with a large number of items. Here we describe the application of the modified method to reducing the number of items in the PVRT to a parsimonious subset of items that accurately predicts the total score. As in our previous reduction studies, a split sample is used for model fitting and validation, with cross-validation to verify results. We find that an 8-item scale predicts the total 29-item score well, achieving a correlation of .9145 for the reduced form for the model fitting sample and .8952 for the validation sample. The results indicate that a drastically abbreviated version, which cuts administration time by more than 70%, can be safely administered as a predictor of PVRT performance. © The Author(s) 2014.

Development of Abbreviated Eight-Item Form of the Penn Verbal Reasoning Test

Science.gov (United States)

Bilker, Warren B.; Wierzbicki, Michael R.; Brensinger, Colleen M.; Gur, Raquel E.; Gur, Ruben C.

2014-01-01

The ability to reason with language is a highly valued cognitive capacity that correlates with IQ measures and is sensitive to damage in language areas. The Penn Verbal Reasoning Test (PVRT) is a 29-item computerized test for measuring abstract analogical reasoning abilities using language. The full test can take over half an hour to administer, which limits its applicability in large-scale studies. We previously described a procedure for abbreviating a clinical rating scale and a modified procedure for reducing tests with a large number of items. Here we describe the application of the modified method to reducing the number of items in the PVRT to a parsimonious subset of items that accurately predicts the total score. As in our previous reduction studies, a split sample is used for model fitting and validation, with cross-validation to verify results. We find that an 8-item scale predicts the total 29-item score well, achieving a correlation of .9145 for the reduced form for the model fitting sample and .8952 for the validation sample. The results indicate that a drastically abbreviated version, which cuts administration time by more than 70%, can be safely administered as a predictor of PVRT performance. PMID:24577310

Preventing adolescents’ externalizing and internalizing symptoms: Effects of the Penn Resiliency Program

Directory of Open Access Journals (Sweden)

J. J. Cutuli

2013-11-01

Full Text Available This study reports secondary outcome analyses from a past study of the Penn Resiliency Program (PRP, a cognitive-behavioral depression prevention program for middle-school aged children. Middle school students (N = 697 were randomly assigned to PRP, PEP (an alternate intervention, or control conditions. Gillham et al., (2007 reported analyses examining PRP’s effects on average and clinical levels of depression symptoms. We examine PRP’s effects on parent-, teacher-, and self-reports of adolescents’ externalizing and broader internalizing (depression/anxiety, somatic complaints, and social withdrawal symptoms over three years of follow-up. Relative to no intervention control, PRP reduced parent-reports of adolescents’ internalizing symptoms beginning at the first assessment after the intervention and persisting for most of the follow-up assessments. PRP also reduced parent-reported conduct problems relative to no-intervention. There was no evidence that the PRP program produced an effect on teacher- or self-report of adolescents’ symptoms. Overall, PRP did not reduce symptoms relative to the alternate intervention, although there is a suggestion of a delayed effect for conduct problems. These findings are discussed with attention to developmental trajectories and the importance of interventions that address common risk factors for diverse forms of negative outcomes.

Final report to DOE: Matching Grant Program for the Penn State University Nuclear Engineering Program

International Nuclear Information System (INIS)

Jack S. Brenizer, Jr.

2003-01-01

The DOE/Industry Matching Grant Program is designed to encourage collaborative support for nuclear engineering education as well as research between the nation's nuclear industry and the U.S. Department of Energy (DOE). Despite a serious decline in student enrollments in the 1980s and 1990s, the discipline of nuclear engineering remained important to the advancement of the mission goals of DOE. The program is designed to ensure that academic programs in nuclear engineering are maintained and enhanced in universities throughout the U.S. At Penn State, the Matching Grant Program played a critical role in the survival of the Nuclear Engineering degree programs. Funds were used in a variety of ways to support both undergraduate and graduate students directly. Some of these included providing seed funding for new graduate research initiatives, funding the development of new course materials, supporting new teaching facilities, maintenance and purchase of teaching laboratory equipment, and providing undergraduate scholarships, graduate fellowships, and wage payroll positions for students

Gay theatre, AIDS, and taboo: reconsidering Robert Chesley.

Science.gov (United States)

Gavrila, Rebecca

2013-01-01

Theatre was among the first popular culture forms to address HIV/AIDS and did so memorably in such works as The Normal Heart, As Is, Love! Valor! Compassion!, and March of the Falsettos. As a response to criticisms of stage dramas focusing on HIV/AIDS in the main as undifferentiated and melodramatic, the author suggests critical consideration of two works by playwright Robert Chesley. In her analysis of Night Sweats and Jerker, the author argues Chesley offers an alternative perspective that is both liberatory and sex-positive.

Robert Hooke (1635-1703), in his own words.

Science.gov (United States)

Breathnach, C S

2003-11-01

The diaries and other writings of Robert Hooke (1635-1703), as well as those of his contemporaries, are drawn upon to sketch his social and scientific life. An account is presented of his involvement with the Royal Society from its earliest days, and of his relations with notable scientists. In exploring the similarity between combustion and respiration, he established that air is composed of different gases, and that it is not motion of the lungs but a supply of fresh air that is necessary for life.

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

Science.gov (United States)

Gerkes, Erica H; van der Kevie-Kersemaekers, Anne-Marie F; Yakin, Mariam; Smeets, Dominique F C M; van Ravenswaaij-Arts, Conny M A

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically mild cases. In the extremely mild case presented here, specific mitotic abnormalities were detected and proved to be very helpful, since Roberts syndrome/SC phocomelia could be diagnosed after finding premature centromere separation and somatic aneuploidy at routine karyotyping. We discuss these and other mitotic cytogenetic abnormalities that can be of significant diagnostic importance, but which will be missed if only array studies are performed. We also discuss the difference between premature centromere separation and premature (sister) chromatid separation. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

Power reactor services provided by the Penn State Radiation Science and Engineering Center

International Nuclear Information System (INIS)

Voth, M.H.; Jester, W.A.

1993-01-01

The power reactor industry emerged from extensive research and development performed at nonpower reactors (NPRs). As the industry matures, NPRs continue to support and enhance power reactor technology. With the closure of many government and private industry NPRS, there is an increasing call for the 33 universities with operating research reactors to provide the needed services. The Penn State Radiation Science and Engineering Center (RSEC) includes a 1-MW pool-type pulsing TRIGA reactor, a neutron beam laboratory with real-time neutron radiography equipment, hot cells with master-slave manipulators for remote handling of radioactive materials, a gamma-ray irradiation pool, a low-level radiation monitoring laboratory, and extensive equipment for radiation monitoring, dosimetry, and material properties determination. While equipment is heavily utilized in the instructional and academic research programs, significant time remains available for service work. Cost recovery for service work generates income for personnel, equipment maintenance, and facility improvements. With decreasing federal and state funding for educational programs, it is increasingly important that facilities be fully utilized to generate supplementary revenue. The following are examples of such work performed at the RSEC

[Robert Schweitzer. Finnland, das Zarenreich und die Deutschen] / Karsten Bgüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2011-01-01

Arvustus: Robert Schweitzer. Finnland, das Zarenreich und die Deutschen : gesammelte Studien zum europäischen Nordosten. Festgabe zum 60. Geburtstag des Verfassers. Hrsg. von Uta-Maria Liertz. (Veröffentlichungen der Aue-Stiftung. Bd. 20) Verlag Schmidt-Römhild

A biography of Robert de Kersauson, French volunteer with the ...

African Journals Online (AJOL)

One of the most colourful foreign volunteers in the Boer army in 1900-1902 was Robert de Kersauson de Pennendreff; young, handsome, gallant and devoted to the Boer cause until the bitter end of the war. His love for South Africa brought him after an absence of almost 40 years back to this country to find a quiet place to ...

Marian Roberts, Developing the Craft of Mediation: Reflections on Theory and Practice

Directory of Open Access Journals (Sweden)

Ghislaine M. Lanteigne

2008-10-01

Full Text Available In Developing the Craft of Mediation, Marian Roberts proposes that mediation is akin to a craft with its focus on learning from experience and from others working in the field to develop and master knowledge and skills.

Tüli Robert Smithsoni "Spiraalse muuli" taastamise ümber / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

2004-01-01

Ameerika maakunstniku Robert Smithsoni (1938-1973) töö "Spiral Jetty" / "Spiraalne muul", mis on ligi 30 aastat seisnud nähtamatult Utah' osariigis Suure Soolajärve põhjas, on praegu kogu ulatuses näha. Teose omanik Dia kunstikeskus on dilemma ees, kas muul restaureerida või mitte

Estudo de dois mapas do geógrafo Robert de Vaugondy relativos ao Reino de Portugal do Século XVIII (1751

Directory of Open Access Journals (Sweden)

Marco Pais Neves dos Santos

2013-07-01

Full Text Available Analisamos dois mapas alusivos ao reino de Portugal, datados de 1751, publicados em Paris e assinados pelo geógrafo Robert de Vaugondy, a saber: Partie Septentrionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751. e Partie Meridionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751., com o objetivo de propor uma explicação para as divisões administrativas cartografadas. Como suporte ao objeto do trabalho, caracterizamos de forma concisa a evolução dos limites administrativos do reino de Portugal, desde a sua formação até a atualidade, e abordamos a vida e obra de Robert de Vaugondy. Concluímos ser o mais consentâneo com a lógica representarem divisões eclesiásticas.

Problem in Two Unknowns: Robert Hooke and a Worm in Newton's Apple.

Science.gov (United States)

Weinstock, Robert

1992-01-01

Discusses the place that Robert Hooke has in science history versus the scientific contributions he made. Examines the relationship between Hooke and his contemporary, Isaac Newton, and Hooke's claims that Newton built on his ideas without receiving Newton's recognition. (26 references) (MDH)

The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.

Science.gov (United States)

Schönberger, Markus; Deutsch, Steven; Manning, Keefe B

2012-01-01

Ventricular assist devices are a commonly used heart failure therapy for adult patients as bridge-to-transplant or bridge-to-recovery tools. The application of adult ventricular assist devices in pediatric patients has led to increased thrombotic events. Therefore, we have been developing a pediatric ventricular assist device (PVAD), the Penn State 12 cc PVAD. It is designed for patients with a body weight of 5-15 kg and has a stroke volume of 12 cc. Clot formation is the major concern. It is correlated to the coagulability of blood, the blood contacting materials and the fluid dynamics within the system. The intent is for the PVAD to be a long term therapy. Therefore, the system may be oriented in different positions according to the patient's behavior. This study evaluates for the first time the impact of position on the flow patterns within the Penn State 12 cc PVAD, which may help to improve the PVAD design concerning chamber and ports geometries. The fluid dynamics are visualized by particle image velocimetry. The evaluation is based on inlet jet behavior and calculated wall shear rates. Vertical and horizontal model orientations are compared, both with a beat rate of 75, outlet pressures of 90/60 mm Hg and a flow rate of 1.3 l/min. The results show a significant change of the inlet jet behavior and the development of a rotational flow pattern. Vertically, the inlet jet is strong along the wall. It initiates a rotational flow pattern with a wandering axis of rotation. In contrast, the horizontal model orientation results show a weaker inlet jet along the wall with a nearly constant center of rotation location, which can be correlated to a higher risk of thrombotic events. In addition, high speed videography illustrates differences in the diaphragm motion during diastole. Diaphragm opening trajectories measurements determine no significant impact of the density of the blood analog fluids. Hence, the results correlate to human blood.

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

NARCIS (Netherlands)

Gerkes, E.H.; Kevie-Kersemaekers, A.M. van der; Yakin, M.; Smeets, D.F.C.M.; Ravenswaaij-Arts, C.M.A. van

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies

NARCIS (Netherlands)

Gerkes, Erica H.; van der Kevie-Kersemaekers, Anne-Marie F.; Yakin, Mariam; Smeets, Dominique F. C. M.; van Ravenswaaij-Arts, Conny M. A.

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

Three-index symmetric matter representations of SU(2) in F-theory from non-Tate form Weierstrass models

Energy Technology Data Exchange (ETDEWEB)

Klevers, Denis [Theoretical Physics Department, CERN,CH-1211 Geneva 23 (Switzerland); Taylor, Washington [Center for Theoretical Physics, Department of Physics, Massachusetts Institute of Technology,77 Massachusetts Avenue Cambridge, MA 02139 (United States)

2016-06-29

We give an explicit construction of a class of F-theory models with matter in the three-index symmetric (4) representation of SU(2). This matter is realized at codimension two loci in the F-theory base where the divisor carrying the gauge group is singular; the associated Weierstrass model does not have the form associated with a generic SU(2) Tate model. For 6D theories, the matter is localized at a triple point singularity of arithmetic genus g=3 in the curve supporting the SU(2) group. This is the first explicit realization of matter in F-theory in a representation corresponding to a genus contribution greater than one. The construction is realized by “unHiggsing” a model with a U(1) gauge factor under which there is matter with charge q=3. The resulting SU(2) models can be further unHiggsed to realize non-Abelian G{sub 2}×SU(2) models with more conventional matter content or SU(2){sup 3} models with trifundamental matter. The U(1) models used as the basis for this construction do not seem to have a Weierstrass realization in the general form found by Morrison-Park, suggesting that a generalization of that form may be needed to incorporate models with arbitrary matter representations and gauge groups localized on singular divisors.

First results from the Penn State Allsky Imager at the Arecibo Observatory

Science.gov (United States)

Seker, I.; Mathews, J. D.; Wiig, J.; Gutierrez, P. F.; Friedman, J. S.; Tepley, C. A.

2007-03-01

The Penn State Allsky imager (PSASI), a user-owned-public-access (UOPA) instrument installed at Arecibo Observatory (AO: 18.3°N, 66.75°W; altitude: 350 m a.s.l.; L = 1.43 at 300 km; dip angle: 46°; geomagnetic coordinates: 29°N, 5.5°E), is a CCD-based high-resolution allsky optical imager that has been collecting ionospheric airglow data at night since May 2003. The computer controlled six-position filter wheel is equipped with three filters at 630 nm (red), 557.7 nm (green), and 777.4 nm (near-IR), respectively, which correspond to ionosphere-related oxygen emissions. The imager data, taken for more than 3.5 years now, is being used to study various ionospheric processes, such as mapped equatorial spread-F plumes, E-region gravity waves, among other, in conjunction with the AO incoherent scatter radar (ISR), mesosphere and lower thermosphere (MLT) metals lidar, and other instruments, including microbarographs. Data availability and quality as well as specific airglow events on both small/large time/spatial scales are examined, categorized, and made freely available at a data-server website. Our goal here is to briefly review the airglow science enabled by allsky imaging at AO, to describe the instrument and the data-collection methodology, and to present some of the significant results, including airglow events that correspond to ISR results.

Robert Aymar awarded the Légion d’honneur

CERN Multimedia

CERN Bulletin

2011-01-01

  On 24 May, Robert Aymar, CERN Director-General from 2004 to 2008, was awarded the Légion d’honneur by the French authorities in recognition of his outstanding scientific career. A renowned French physicist, he was Director of the superconducting tokamak Tore Supra from 1977 to 1988, Director of Material Sciences at the CEA in 1990 and Director of the ITER project in 1994. His term of office as CERN Director-General was marked in particular by the commissioning and start-up of the LHC machine, which he inaugurated on 21 October 2008.        

Robert Hooke, inventor of the vacuum pump and the first altitude chamber (1671).

Science.gov (United States)

Harsch, Viktor

2006-08-01

Robert Hooke (1635-1703), an assistant researcher to Robert Boyle (1627-1691), invented the first functional British air pump. Applying it to scientific research, Hooke operated the world's first hypobaric chamber in 1671, using it for self-experimentation. He recorded the first physiological observations in an artificial altitude-equivalent environment up to 2400 m. Though Hooke's experiment showed some methodological insufficiencies, his imaginative experimental techniques were remarkable for their time and were indicative of the lively intellectual atmosphere of the Royal Society and the significant contributions of Hooke, who was a member. Two centuries passed before the French physiologist Paul Bert (1830-1886) conducted his famous laboratory-supported investigations of high altitude physiology. Bert played a decisive role in the discovery of the causes of decompression sickness; a contribution Hooke could not make due to the technical deficiencies of the 17th century.

Hodorkovski advokaat : Venemaa ei ole õigusriik / Robert R. Amsterdam ; interv. Aleksei Günter

Index Scriptorium Estoniae

Amsterdam, Robert R.

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 24. juuli lk. 10. Naftamagnaadi Mihhail Hodorkovski advokaat vastab küsimustele, mis puudutavad ärimehe olukorda ja elamistingimusi vanglas ning tema võimalust ennetähtaegselt vabaneda. Lisa: Robert R. Amsterdam

An Environment for Treating Youthful Offenders: The Robert F. Kennedy Youth Center

Science.gov (United States)

Johnson, V. Scott

1977-01-01

Describes goals of the Robert F. Kennedy Youth Center (KYC) and the philosophical stance and the implementation of that philosophy within the center. Issues discussed range from administrative structure through descriptions of inmate classification and treatment. Educational and vocational programs as well as the token economy systems are…

Saksa filmilootusega tänavaelust ja hullusest / Robert Stadlober ; interv. Janno Zõbin

Index Scriptorium Estoniae

Stadlober, Robert

2002-01-01

Pimedate Ööde Filmifestivalil näidatud saksa mängufilmis "Engel & Joe" (režissöör Vanessa Jopp) ühes peaosas esines festivali külastanud saksa näitleja Robert Stadlober (1982). Näitleja Engeli rollist ja oma elukogemusest, mis aitas seda rolli kehastada

American Community Colleges in Crisis--A Conversation with Robert H. McCabe.

Science.gov (United States)

Dubocq, Tom

1981-01-01

Educational reform by Miami-Dade Community College is discussed by its president, Robert H. McCabe. In an action that is considered unusual for two-year schools, it has tightened controls on its curriculum, faculty, and students. A commitment to achieving higher levels of literacy is advocated. (MLW)

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

Science.gov (United States)

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

78 FR 51802 - Culturally Significant Objects Imported for Exhibition Determinations: “Robert Motherwell: The...

Science.gov (United States)

2013-08-21

... ``Robert Motherwell: The Early Collages,'' imported from abroad for temporary exhibition within the United... the Solomon R. Guggenheim Museum, New York, New York, from on or about September 27, 2013, until on or...

Robert Priddle talking straight

International Nuclear Information System (INIS)

Anon

2000-01-01

A keynote speaker at Outlook 2001 conference, Robert Priddle, Executive Director of the International Energy Agency, provided a realistic assessment of the opportunities for a change in the energy supply mix in the light of the growing international debate about the design of a sustainable energy future. World energy supply today is based firmly on fossil fuels. Furthermore, projections of future supply, such as that made in the reference case of the recent World Energy Outlook by the IEA, indicate little change. Yet government's remain deeply engaged in efforts to reshape energy markets including (despite the failure of COP-6 in The Hague last November) efforts to curb national emissions of greenhouse gases, in particular from the energy sector. Australia has made considerable progress in developing and applying life cycle analysis to the energy sector. This effort demonstrates opportunities to combine, for example, coal seam methane capture, coal and biomass co-combustion, coal power generation and steel production and thus to reduce emissions by up to 15%. The prospect is that even with effective carbon constraints reflected in fuel prices, coal can remain a competitive fuel choice for longer than many analysts imagine. The outcome does not rely on exotic technology development, rather it requires the necessary market signals to create new business partnerships

Robert Owen: A Historiographic Study of a Pioneer of Human Resource Development

Science.gov (United States)

Hatcher, Tim

2013-01-01

Purpose: The purpose of this paper is to investigate the ideals and activities of the nineteenth century Welsh industrialist and reformer Robert Owen (1771-1858), and how they informed modern human resource development (HRD) concepts and practices and provided evidence of Owen as a HRD pioneer. Design/methodology/approach: Historiography provided…

Research, Learning Theory, and the Ideas of Robert G. Sidnell. Special Issue.

Science.gov (United States)

Alexander, David, Ed.; And Others

1987-01-01

Intended as a memorial to Robert G. Sidnell, this special issue contains articles about areas of music education which he promoted. In "The Dimensions of Research in Music Education," Sidnell concluded that music education research encompasses all humanistic disciplines as well as the behavioral and social sciences. James Carlsen, in…

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity

NARCIS (Netherlands)

Gordillo, Miriam; Vega, Hugo; Trainer, Alison H.; Hou, Fajian; Sakai, Norio; Luque, Ricardo; Kayserili, Hülya; Basaran, Seher; Skovby, Flemming; Hennekam, Raoul C. M.; Uzielli, Maria L. Giovannucci; Schnur, Rhonda E.; Manouvrier, Sylvie; Chang, Susan; Blair, Edward; Hurst, Jane A.; Forzano, Francesca; Meins, Moritz; Simola, Kalle O. J.; Raas-Rothschild, Annick; Schultz, Roger A.; McDaniel, Lisa D.; Ozono, Keiichi; Inui, Koji; Zou, Hui; Jabs, Ethylin Wang

2008-01-01

Roberts syndrome/SC phocomelia (RBS) is an autosomal recessive disorder with growth retardation, craniofacial abnormalities and limb reduction. Cellular alterations in RBS include lack of cohesion at the heterochromatic regions around centromeres and the long arm of the Y chromosome, reduced growth

Using Performance as an Interpretive Strategy in Teaching Robert Browning's "My Last Duchess."

Science.gov (United States)

Schevera, Nicholas

1997-01-01

Uses role-playing, dramatic monologues, and "tableaux vivant" to interpret Robert Browning's poem "My Last Duchess" in an introductory literature class at Westchester Community College. Notes that performative strategies illustrate connections in the poem that often remain unnoticed on a first reading. (PA)

4th Penn State Bioinorganic Workshop

Energy Technology Data Exchange (ETDEWEB)

Krebs, Carsten [Pennsylvania State Univ., University Park, PA (United States)

2017-08-22

Pennsylvania State University and our unique laboratory space are well suited for the continuation of such training workshops. The co-principal investigators of this award lead these efforts. After a smaller “trial workshop” in 2010, the Penn State bioinorganic group, led by the co-PIs, offers these workshops biennially. The 2012, 2014, and 2016 workshops provided training to 123, 162, and 153 participants, respectively, by offering (i) a series of lectures given by faculty experts on the given topic, (ii) hands-on training in small groups by experts in the various methods, and (iii) sharing research results of the participants by oral and poster presentations. The centerpiece of the workshops is the hands-on training, in which approximately half of the participants from all ranks (undergraduate students to faculty) served as teachers. In this section, the traditional roles of teachers and students were sometimes reversed to the extent that undergraduate students taught faculty in the students' areas of specialty. We anticipate that these workshops will facilitate research in bioinorganic chemistry and will help establish future collaborations among “workshop alumni” to carry out cutting-edge research in bioinorganic chemistry that will address many important topics relevant to our society.

The strange trial of Robert Oppenheimer

International Nuclear Information System (INIS)

Kevles, D.J.

2004-01-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Summary Robert Noyce and the invention of Silicon Valley

CERN Document Server

2014-01-01

This work offers a summary of the book "THE MAN BEHIND THE MICROCHIP: Robert Noyce and the Invention of Silicon Valley""by Leslie Berlin.The Man behind the Microchip is Leslie Berlin's first book. This author is project historian for the Silicon Valley Archives, a division of the Stanford University Department of Special Collections. This book tells the story of a giant of the high-tech industry: the multimillionaire Bob Noyce. This co-founder of Fairchild Semiconductor and Intel co-invented the integrated circuit which became the electronic heart of every modern computer, automobile, advance

Robert Wiltrout Says Goodbye to NCI in 2015 | Poster

Science.gov (United States)

After 34 years at NCI, Robert Wiltrout, Ph.D., said he is looking forward to trading his I-270 commute for another type of commute: exploring the waterways of Maryland, Alaska, and Wyoming to fulfill his love of fishing. Wiltrout officially retired as director of the NCI Center for Cancer Research (CCR) on July 2 of last year. Throughout his college academic career, Wiltrout had an interest in science, but it was not until he was working on a research project for his master’s degree that he considered a career in scientific research.

Welcoming the Sunlight: A Conversation with Mary Kay Zabel and Robert Zabel

Science.gov (United States)

Teagarden, James; Kaff, Marilyn

2018-01-01

Professors Emeriti Mary Kay and Robert Zabel share their reflections on their long and productive careers working with students and teachers. Their respective careers share much of the same history and complement each other. The Zabels share their advice with those entering the field and the challenges they see for the education of students with…

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

Energy Technology Data Exchange (ETDEWEB)

Fraser, Hamish L. [The Ohio State University (United States); Smith, David J., E-mail: david.smith@asu.edu [Arizona State University (United States); Wittig, James E. [Vanderbilt University (United States)

2017-05-15

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights.

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

International Nuclear Information System (INIS)

Fraser, Hamish L.; Smith, David J.; Wittig, James E.

2017-01-01

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights

James George Frazer’s Anthropologic Heritage in the Work of Robert Graves

Directory of Open Access Journals (Sweden)

Tomislav M. Pavlović

2016-02-01

Full Text Available The works of Sir James George Frazer had an outstanding influence on the literature of modernism. Among those who benefited from Frazer’s ritualism were W. B. Yeats, T. S. Eliot. James Joyce, Ernest Hemingway, D. H. Lawrence, Ezra Pound, Mary Renault, Joseph Campbell, Robert Graves and many others. Robert Graves was known for his famous adaptation of Frazer’s concept of the sacred king who is sacrificed for the benefit of his subjects thus forming the narrative frame for the one of his most controversial novels. The dying king is also identified with the poet striving to attain the favour of the Triple Muse Goddess - who represents the embodiment of true poetic inspiration. The aforementioned concept is not the only thing that Graves inherited from his famous ancestor. In our analysis we laid stress on the customs, rituals, magic symbols and deities both authors dealt with. We also observed a striking resemblance of the style Greves and Frazer developed and their euchemeristic approach to myths as well.

Návrh zásobníku na sypký vápenný hydrát

OpenAIRE

Perna, Marek

2009-01-01

Tato diplomová práce řeší návrh hlubokého zásobníku na sypký vápenný hydrát pro technologická zařízení čistíren odpadních vod. Je zde proveden rozbor volby typu a konstrukce zásobníku, návrh rozměrů a pevnostní výpočet zásobníku. Je zde popsána možnost vzniku klenby při vyprazdňování a její potlačení pomocí aktivních a pasivních prvků napomáhající toku. Popis aktivních a pasivních stavů napjatosti materiálu v zásobníku. This diploma thesis is solving systems design of silo for a powdery li...

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

Robert Lévy-Mandel (1923-2010)

CERN Multimedia

2010-01-01

Former CERN Director Robert Lévy-Mandel passed away on 3 July at the age of 87.   After obtaining a diploma from the Institut polytechnique in Grenoble, in 1948 he started work at the CEA, and was involved in the development and construction of the Saclay institute's first particle accelerator, a Van de Graaff machine. From 1954 to 1957 he was responsible for the coordination, development and construction of the CEA’s Saturne synchrotron, which entered service in 1958. In 1963 he was appointed head of the Saturne Synchrotron Department. The team led the construction of the Gargamelle bubble chamber, which was installed at CERN, and made contributions to other major facilities, including the Big European Bubble Chamber (BEBC). In 1971 he was invited to come to Geneva by John Adams, who was in charge of the SPS accelerator project. With the start of the SPS project, CERN had two laboratories, one at Meyrin and one at Prévessin, each with its own Director General: ...

Robert Musil y los Estados desunificados de Europa

Directory of Open Access Journals (Sweden)

Bayón, Fernando

2006-12-01

Full Text Available This article is a study of Robert Musil´s work “The Man Without Qualities” from philosophical sources. It is a novel that has produced so many overriding metaphors through which we can better understand the crises of the social identity on the horizont of the last modernity in Europe. Much of the key-concepts that helped in creating the so called “Leyend of Modernity” start to vanish in an irremediable way: not only did Musil trace the disappearance of the support for national aspirations and social cohesion, he also showed us how culture is a mad carrousel of collapsed expectations, and how the prevailing idea of “subjectivity” lacks today any solid or essential nucleus. In the middle of this disenchanted landscape of Europe, where all the modern and clasical illusions became nothing, appears however “a new human being”, since the man “without qualities” is the man with endless possibilities too.El presente ensayo es una interpretación de la novela de Robert Musil “El hombre sin atributos” a partir de fuentes filosóficas. Se trata de una obra que ha producido algunas metáforas decisivas para comprender las crisis de la identidad social en el horizonte de la última modernidad europea. Muchos de los conceptos clave que ayudaron a crear la leyenda de la modernidad empiezan a erosionarse de modo irreversible: se descomponen las aspiraciones nacionales, el sujeto pierde su núcleo sustancial y la cultura es un carrusel de esperanzas abortadas incapaces de responder a ninguna idea rectora. Y, sin embargo, en el paisaje de esta Europa tardomoderna en que se han agotado las pasadas ilusiones surge la idea de que el “hombre sin atributos” es también el “hombre de las posibilidades”.

Compton suppression system at Penn State Radiation Science and Engineering Center

International Nuclear Information System (INIS)

Cetiner, N.Oe.; Uenlue, K.; Brenizer, J.S.

2008-01-01

A Compton suppression system is used to reduce the contribution of scattered gamma-rays that originate within the HPGe detector to the gamma ray spectrum. The HPGe detector is surrounded by an assembly of guard detectors, usually NaI(Tl). The HPGe and NaI(Tl) detectors are operated in anti-coincidence mode. The NaI(Tl) guard detector detects the photons that Compton scatter within, and subsequently escape from the HPGe detector. Since these photons are correlated with the partial energy deposition within the detector, much of the resulting Compton continuum can be subtracted from the spectrum reducing the unwanted background in gamma-ray spectra. A commercially available Compton suppression spectrometer (CSS) was purchased from Canberra Industries and tested at the Radiation Science and Engineering Center at Penn State University. The PSU-CSS includes a reverse bias HPGe detector, four annulus NaI(Tl) detectors, a NaI(Tl) plug detector, detector shields, data acquisition electronics, and a data processing computer. The HPGe detector is n-type with 54% relative efficiency. The guard detectors form an annulus with 9-inch diameter and 9-inch height, and have a plug detector that goes into/out of the annulus with the help of a special lift apparatus to raise/lower. The detector assembly is placed in a shielding cave. State-of-the-art electronics and software are used. The system was tested using standard sources, neutron activated NIST SRM sample and Dendrochronologically Dated Tree Ring samples. The PSU-CSS dramatically improved the peak-to-Compton ratio, up to 1000 : 1 for the 137 Cs source. (author)

Robert Hooke: early respiratory physiologist, polymath, and mechanical genius.

Science.gov (United States)

West, John B

2014-07-01

Robert Hooke (1635-1703) was a polymath who made important contributions to respiratory physiology and many other scientific areas. With Robert Boyle, he constructed the first air pump that allowed measurements on small animals at a reduced atmospheric pressure, and this started the discipline of high-altitude physiology. He also built the first human low-pressure chamber and described his experiences when the pressure was reduced to the equivalent of an altitude of ∼2,400 m. Using artificial ventilation in an animal preparation, he demonstrated that movement of the lung was not essential for life. His book Micrographia describing early studies with a microscope remains a classic. He produced an exquisite drawing of the head of a fly, showing the elaborate compound eye. There is also a detailed drawing of a flea, and Hooke noted how the long, many-jointed legs enable the insect to jump so high. For 40 years, he was the curator of experiments for the newly founded Royal Society in London and contributed greatly to its intellectual ferment. His mechanical inventions covered an enormous range, including the watch spring, the wheel barometer, and the universal joint. Following the Great Fire of London in 1666, he designed many of the new buildings in conjunction with Christopher Wren. Unfortunately, Hooke had an abrasive personality, which was partly responsible for a lack of recognition of his work for many years. However, during the last 25 years, there has been renewed interest, and he is now recognized as a brilliant scientist and innovator. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

Robert Frazure mälestuspuu Sõpruse pargis sai graniitpotil tähistuse / Raivo Feldmann

Index Scriptorium Estoniae

Feldmann, Raivo

2007-01-01

Esimese USA suursaadiku sõjajärgses Eestis, Robert Frazure' mälestuspuu sai Sõpruse pargis tähise, vajaliku raha ettevõtmise heaks annetasid Ameerika Suursaatkonna töötajad, nende delegatsioon viibis Põltsamaal Sõpruse pargis toimunud üritusel

Improvements to the Understanding of the Fire Performance of Wood over the Past 30 Years-A Tribute to Robert Hawthorne White

Science.gov (United States)

Samuel L. Zelinka; Mark A. Dietenberger; Laura E. Hasburgh; Keith J. Bourne; Charles Boardman

2015-01-01

Dr. Robert Hawthorne White had a 31 year career researching the fire performance of wood and wood composites at the USDA Forest Products Laboratory. Over his career, Dr. White made substantial contributions to codes, standards, and regulations pertaining to the design of wood structures. This review article summarizes Robert’s major accomplishments as a tribute to his...

The man behind the microchip Robert Noyce and the invention of Silicon Valley

CERN Document Server

Berlin, Leslie

2005-01-01

Robert Noyce was a brilliant inventor, a leading entrepreneur and a daring risk taker, who piloted his own jets and skied mountains accessible only by helicopter. This book captures not only this colorful individual, but also the vibrant interplay of technology, business, money, politics and culture that defines the Silicon Valley.

USA kaitseminister Robert Gates süüdistas liitlasvägesid oskamatuses / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2008-01-01

USA kaitseminister Robert Gates väitis ajalehes The Los Angeles Times avaldatud intervjuus, et Lõuna-Afganistani olukord on halvenenud seal võitlevate USA liitlasvägede puuduliku väljaõppe tõttu. Liitlasriikide reageeringuid. Arvamust avaldavad Jaak Aaviksoo, Kaarel Kaas

Changements à la tête du CERN - Robert Aymar aux commandes pour 5 ans.

CERN Multimedia

2003-01-01

"Une nouvelle équipe prendra les rênes du CERN à partir du 1er janvier. Le Francais Robert Aymar, anciennement directeur du Projet de reacteur thermonucleaire experimental international (ITER), dirigera le centre de recherche pour la periode 2004-2008" (1 page).

Cosmic Thing: Astrology, Space Science, and Personal Cartography in Robert Rauschenberg's Autobiography

Science.gov (United States)

Carey, C. L.

2011-06-01

The following paper undertakes an iconographic analysis of Robert Rauschenberg's large scale print, Autobiography (1967). The artist's interest in astronomy and astrology, visual metaphors aligning the body with the cosmos, and the cartographic representation of self are discussed. Autobiography is placed in cultural and historical context with other works by the artist, elaborated as a personal narrative-an alternative to traditional self portraiture.

The Postsouthern Sense of Place in Contemporary Fiction

DEFF Research Database (Denmark)

Bone, Martyn Richard

—and on the nation generally—including that self-declared "international city" Atlanta. Close readings of novels by Robert Penn Warren, Walker Percy, Richard Ford, Anne Rivers Siddons, Tom Wolfe, and Toni Cade Bambara illuminate evolving ideas about capital, land, labor, and class while introducing southern literary......, in their definitions of southern identity. For them, the South seemed an organic and rooted region in contrast to the North, where real estate development and urban sprawl evoked a faceless, raw capitalism. By the end of the twentieth century, however, economic and social forces had converged to create a modernized...

Homosexual orientation-from nature, not abuse: A critique of Roberts, Glymour, and Koenen (2013).

Science.gov (United States)

Rind, Bruce

2013-11-01

Roberts, Glymour, and Koenen (2013), using instrumental variable models, argued that child abuse causes homosexual orientation, defined in part as any same-sex attractions. Their instruments were various negative family environment factors. In their analyses, they found that child sexual abuse (CSA) was more strongly related to homosexual orientation than non-sexual maltreatment was, especially among males. The present commentary therefore focused on male CSA. It is argued that Roberts et al.'s "abuse model" is incorrect and an alternative is presented. Male homosexual behavior is common in primates and has been common in many human societies, such that an evolved human male homosexual potential, with individual variation, can be assumed. Cultural variation has been strongly influenced by cultural norms. In our society, homosexual expression is rare because it is counternormative. The "counternormativity model" offered here holds that negative family environment weakens normative controls and increases counternormative thinking and behavior, which, in combination with sufficient homosexual potential and relevant, reinforcing experiences, can produce a homosexual orientation. This is a benign or positive model (innate potential plus release and reinforcement), in contrast to Roberts et al.'s negative model (abuse plus emotional compensation or cognitive distortion). The abuse model is criticized for being based on the sexual victimological paradigm, which developed to describe the female experience in rape and incest. This poorly fits the gay male experience, as demonstrated in a brief non-clinical literature review. Validly understanding male homosexuality, it is argued, requires the broad perspective, as employed here.

Color and Contingency in Robert Boyle's Works.

Science.gov (United States)

Baker, Tawrin

2015-01-01

This essay investigates the relationship between color and contingency in Robert Boyle's Experiments and Considerations Touching Colours (1664) and his essays on the unsuccessfulness of experiments in Certain Physiological Essays (1661). In these two works Boyle wrestles with a difficult practical and philosophical problem with experiments, which he calls the problem of contingency. In Touching Colours, the problem of contingency is magnified by the much-debated issue of whether color had any deep epistemic importance. His limited theoretical principle guiding him in Touching Colours, that color is but modified light, further exacerbated the problem. Rather than theory, Boyle often relied on craftsmen, whose mastery of color phenomena was, Boyle mentions, brought about by economic forces, to determine when colors were indicators of important 'inward' properties of substances, and thus to secure a solid foundation for his experimental history of color.

Study of plasma binding of receptor-specific peptides

OpenAIRE

Gregor, David

2008-01-01

The binding ability of two receptor specific peptides namely 90Y-DOTA-TATE and 111In-DOTA-TATE was studied in therm of interspecies comparison by the method of equilibrium dialysis. This plasma protein binding was different for the chosen animal species (human, rat, rabbit, bovine eventually pork) whereas binding of 90Y-DOTA- TATE was higher than binding of 111In-DOTA-TATE. KEYWORDS: Protein binding, radiofarmaceuticals, equilibrium dialysis, 90Y-DOTA-TATE, 111In- DOTA-TATE

The creativity of Crumb: research on the effects of psychedelic drugs on the comic art of Robert Crumb.

Science.gov (United States)

Jones, Matthew T

2007-09-01

This article investigates the influence of perception that is altered by psychedelic drugs on processes of creativity through a case study of the work of well-known comic artist Robert Crumb. Samples of Crumb's work before, during, and after the period of his use of psychedelic drugs are content analyzed and compared according to the categorization offered by Janiger and Dobkin de Rios (1989). The results of the comparison indicate that Robert Crumb's drug use significantly altered the stylistic approach of his artwork not only during the period of his drug use, but long after he had stopped using drugs.

Robert Kramer: técnica, paixão e ideologia

Directory of Open Access Journals (Sweden)

Jorge La Ferla

2011-01-01

Full Text Available Uma revisão crítica da obra do cineasta Robert Kramer, considerando as relações que propõe sua obra, a partir da utilização virtuosa de diversas máquinas audiovisuais em suas especificidades e combinações. O cinema, o vídeo, a televisão e as novas tecnologias constituem, em Kramer, processos de criação que dão origem a um trabalho expressivo com os dispositivos fotoquímicos, eletrônicos e digitais.

[Margaret Cavendish vs Robert Hooke: An impossible duel].

Science.gov (United States)

Aït-Touati, Frédérique

2016-12-01

In 1665, Robert Hooke published his major work in microscopy, Micrographia, a defense of experimental philosophy. The following year, Margaret Cavendish, Duchess of Newcastle, published at her own expense a treatise and a novel that undermined the basis of this new science. The dispute broke out at the initiative of the Duchess, in the context of a vast controversy about the legitimacy and the efficiency of optical instruments in natural philosophy. All the figures of the dual are used, except one: the counterattack. Cavendish, indeed, was alone on the battlefield. Is it possible to call a dual a battle with only one combatant? This particular case of dispute that stops owing to the shortage of combatants is the subject of this article.

USA mõtleja : vaid rikkus riiki koos ei hoia / Robert Putnam ; interv. Erkki Bahovski

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

USA Harvardi ülikooli politoloogiaprofessori Robert Putnami arvates on etniliselt mitmekesistes riikides ühtsustunde loomine raske, selle saavutamisele aitaksid kaasa ühiskonna pingevabam enesemääratlus ning paindlikumad töögraafikud naistele ühendamaks pere tööga. Lisa: Üksi või koos?

Empirical Asset Pricing: Eugene Fama, Lars Peter Hansen, and Robert Shiller

OpenAIRE

Campbell, John Y.

2016-01-01

The Nobel Memorial Prize in Economic Sciences for 2013 was awarded to Eugene Fama, Lars Peter Hansen, and Robert Shiller for their contributions to the empirical study of asset pricing. Some observers have found it hard to understand the common elements of the laureates research, preferring to highlight areas of disagreement among them. This paper argues that empirical asset pricing is a coherent enterprise, which owes much to the laureates seminal contributions, and that important themes in ...

Kolm vaadet Tallinna vanalinnale / Villem Tomiste, Martin Aunin, Robert Treufeldt ; intervjueerinud Ingrid Ruudi

Index Scriptorium Estoniae

Tomiste, Villem, 1975-

2009-01-01

Tallinna vanalinna ja kesklinna piiril asuv kvartal 57B, mis piirneb Aia, Vana-Viru, Inseneri tänava ja Mere Puiesteega, ajendas vanalinna hoonestuspõhimõtete ja tulevikulahenduste üle arutama arhitekte Villem Tomistet, Martin Auninit ning arhitektuuriajaloolast, ICOMOSi Eesti komitee esimeest Robert Treufeldti. Pikemalt korterelamust Aia 4/Vana-Viru 13, Aia 6 ja 8 detailplaneeringu eskiisist

More Misbehavior of Organisms: A Psi Chi Lecture by Marian and Robert Bailey

Science.gov (United States)

Bihm, Elson M.; Gillaspy, J. Arthur, Jr.; Abbott, Hannah J.; Lammers, William J.

2010-01-01

In 1992, Dr. Marian Breland Bailey, assisted by her husband Robert E. Bailey, gave the following presentation at the Psi Chi Banquet of the University of Central Arkansas. She and her first husband, Keller Breland, were students of B. F. Skinner and established Animal Behavior Enterprises (ABE) in 1947 and the IQ Zoo in 1955. Unknown to many…

Robert Aymar awarded Global Energy prize

CERN Multimedia

2006-01-01

CERN Director-General Robert Aymar was recently named one of three laureates of the 2006 Global Energy International Prize for 'the development of scientific and engineering foundation for the ITER project.' ITER is an experiment planned to be built in Europe at Cadarache (South of France) and designed to show the scientific and technological feasibility of a full-scale fusion power reactor. The other two laureates, who worked with Aymar on the project, are former President of the ITER Council, Russian Academician Evgeny Velikhov, and Japan's Dr Masaji Yoshikawa, ITER's former Vice President. Aymar headed ITER from 1994 to 2003. 'This prize is not only a great honour for me and my friends and colleagues of many years at ITER, Evgeny Velikhov and Masaji Yoshikawa,' Aymar said. 'It is above all a recognition of the effort of all those who have been involved with the ITER project and worked over the years to ensure the first step in proving that fusion will provide a new sustainable energy source for the plane...

The contribution of skin blood flow in warming the skin after the application of local heat; the duality of the Pennes heat equation.

Science.gov (United States)

Petrofsky, Jerrold; Paluso, Dominic; Anderson, Devyn; Swan, Kristin; Yim, Jong Eun; Murugesan, Vengatesh; Chindam, Tirupathi; Goraksh, Neha; Alshammari, Faris; Lee, Haneul; Trivedi, Moxi; Hudlikar, Akshay N; Katrak, Vahishta

2011-04-01

As predicted by the Pennes equation, skin blood flow is a major contributor to the removal of heat from an external heat source. This protects the skin from erythema and burns. But, for a person in a thermally neutral room, the skin is normally much cooler than arterial blood. Therefore, if skin blood flow (BF) increases, it should initially warm the skin paradoxically. To examine this phenomenon, 10 young male and female subjects participated in a series of experiments to examine the contribution of skin blood flow in the initial warming the skin after the application of local heat. Heat flow was measured by the use of a thermode above the brachioradialis muscle. The thermode was warmed by constant temperature water at 44°C entering the thermode at a water flow rate of 100 cm(3)/min. Skin temperature was measured by a thermistor and blood flow in the underlying skin was measured by a laser Doppler imager in single point mode. The results of the experiments showed that, when skin temperature is cool (31-32°C), the number of calories being transferred to the skin from the thermode cannot account for the rise in skin temperature alone. A significant portion of the rise in skin temperature is due to the warm arterialized blood traversing the skin from the core areas of the body. However, as skin temperature approaches central core temperature, it becomes less of a heat source and more of a heat sync such that when skin temperature is at or above core temperature, the blood flow to the skin, as predicted by Pennes, becomes a heat sync pulling heat from the thermode. Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.

Teorizando o mundo contemporâneo: Robert Brenner; Giovanni Arrighi; David Harvey

Directory of Open Access Journals (Sweden)

Moishe Postone

2008-07-01

Full Text Available O artigo busca apreender as profundas transformações sociais, políticas, econômicas e culturais que marcaram as três últimas décadas, em contraste com o período de prosperidade subseqüente à Segunda Guerra Mundial. Para tanto, o autor analisa criticamente três obras específicas que abordam o período: "The economics of global turbulence", de Robert Brenner, O longo século XX, de Giovanni Arrighi, e A condição pós-moderna, de David Harvey. O procedimento metateórico adotado permite apontar os requisitos de uma teoria crítica adequada ao capitalismo contemporâneo.The article aims to apprehend the deep social, political, economic and cultural transformations that characterized the three last decades, in contrast with the prosperity period following the Second World War. Therefore, the author critically analyses three specific works that deal with that period: "The economics of global turbulence", by Robert Brenner, The long Twentieth Century, by Giovanni Arrighi, and The conditions of postmodernity, by David Haravey. The metatheoric procedure adopted allows him to indicate the requisites of an adequate critical theory of contemporary capitalism.

Robert Bartini and His Contribution to the Development of Transport and Aviation

Science.gov (United States)

Težak, Sergej

2017-10-01

After the First World War, the young Soviet Union (USSR) desperately needed new engineers and scientists who would provide the new country with development of modern industry and transportation. At that time, Western European countries had knowledge and experience, especially in the field of aviation. One of the young engineers was Robert Bartini, who was educated in Austria-Hungary and Italy, and graduated from Milan Polytechnic Institute. In 1923, he fled Italy to escape Fascists and emigrated in Soviet Union. This article is a brief description of aircraft designer Robert Bartini and his role in the development of the military, passenger and transport aviation. In addition, it presents his vision of the intercontinental and continental high-speed transport, which was his focus in the last years of his work and creation. He worked as a researcher and expert in the former Soviet Union, therefore, more detailed and relevant information on his work has been revealed to the public in recent years. In Russia, he is very popular as a researcher and developer. There are many books about him in Russian and Italian language, but not in English. Thus, his work is still quite unknown in the West. He was born in Kanjiza (today Serbia) in 1897, and spent his youth in Fiume (Rijeka, today Croatia).

Los orígenes del grial en la literatura medieval: de Chrétien de Troyes a Robert de Boron

Directory of Open Access Journals (Sweden)

Mario Martín Botero

2010-12-01

Full Text Available Este artículo muestra el origen literario del tema del Grial en la literatura medieval francesa, abordando dos textos esenciales para el surgimiento y consolidación de la “literatura del Grial”: Le Conte du Graal de Chrétien de Troyes y Le Roman de l’Estoire dou Graal de Robert de Boron. Los autores de estas obras establecen las bases para el desarrollo de toda una temática que gira alrededor del Grial a partir del siglo XII hasta nuestros días. El artículo muestra cómo de un objeto apenas sagrado en el texto de Chrétien de Troyes se pasa a una reliquia de la sangre de Cristo en la versión de Robert de Boron.This paper studies the literary origin of the Grail legend in medieval French literature, taking into account two important romances: Le Conte du Graal by Chrétien de Troyes and Le Roman de l’Estoire dou Graal by Robert de Boron. In these two texts the authors established the basis for the development of a new subject matter around the mysterious object called “Grail” from the Middle Ages to the present times. It will also be shown how an object, not totally sacred in Chrétien de Troyes, becomes a relic related with Jesus’s blood in Robert de Boron.

The Impossibility of Maintaining the Minimal State of Robert Nozick

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Virgílio Queiroz de Paula

2015-12-01

Full Text Available In this paper we analyze how Robert Nozicks minimal state proposed would invariably end, unless its members were coerced by the central government to contribute to its maintenance. And, in this case, rights and freedom protected under the philosophers state would obviously be violated. We also analyze the flaws in Nozicks model through economic bias in order to show - through game theory and logic of collective action  how an organization that provides nonexclusive public goods is vulnerable to the action of free-riders, thus increasing the costs of its performance, and decreasing motivation for its existence.

Taasavatud mälestuskivi väärtustab Robert von Tolli tegemisi / Külli Kriis

Index Scriptorium Estoniae

Kriis, Külli, 1961-

2007-01-01

26. juulil taasavati Kukruse külas mälestuskivi, mille Kukruse mõisa omanik Robert von Toll sinna aastal 1866 pargi rajamise puhul püstitas. Ilmunud ka: Severnoje Poberezhje, 28. juuli 2007 (Vnov ustanovlennõi kamen - dan pamjati dejatelnosti Roberta fon Tollja)

Robert Williams Wood: pioneer of invisible light.

Science.gov (United States)

Sharma, Shruti; Sharma, Amit

2016-03-01

The Wood's lamp aids in the diagnosis of multiple infectious, inflammatory and neoplastic dermatologic conditions. Although the Wood's lamp has many applications, which have improved both the diagnosis and management of disease, the man credited for its invention is relatively unknown in medicine. Robert Williams Wood, a prominent physicist of the early 20th century, is credited for the invention of the Wood's lamp. Wood was the father of infrared and ultraviolet photography and made significant contributions to other areas in optics and spectroscopy. Wood's work encompassed the formative years of American Physics; he published over 200 original papers over his lifetime. A few years after the invention of the Wood's lamp for ultraviolet photography, physicians in Europe adopted the Wood's lamp for dermatologic applications. Wood's lamp remains popular in clinics globally, given its ease of use and ability to improve diagnostic precision. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Reproduction of the San Joaquin kit fox (Vulpes velox macrotis) on Camp Roberts Army National Guard Training Site, California

International Nuclear Information System (INIS)

Spencer, K.A.; Berry, W.H.; Standley, W.G.; O'Farrell, T.P.

1992-09-01

The reproduction of a San Joaquin kit fox population (Vulpes velox macrotis) was investigated at Camp Roberts Army National Guard Training Site, California, from November 1988 through September 1991. Of 38 vixens radiocollared prior to parturition, 12 (32%) were successful in raising pups from conception to the point where pups were observed above ground. No yearling vixens were known tb be reproductively active. The mean litter size during 1989 - 1991 was 3.0 (n = 21, SE = 0.28) and ranged from one to six pups. Both the proportion of vixens successfully raising pups and the mean litter size observed at Camp Roberts during this study were lower than those reported at other locations. Sex ratios of kit fox pups were male biased two of the three years, but did not differ statistically from 1:1 throughout the study. Whelping was estimated to occur between February 15 and March 5. Results of this study support previous reports that kit foxes are primarily monogamous, although one case of polygamy may have occurred. Both the proportion of dispersing radiocollared juveniles (26%) and the mean dispersal distance (5.9 km) of juveniles at Camp Roberts appeared low compared to other locations

Robert Michels y las teorías elitista-competitivas de la democracia

OpenAIRE

Caparrós Valderrama, Rafael

2008-01-01

Robert Michel's main work is "Political parties. A Sociological Study on the Oligarchical Tendencies of Modern Democracy", issued in 1911, which is an analysis on the internal organization evolving dynamics of the German Social-Democrat Party (SDP), to which the author was intensely attached for several years. The aim of this essay is hte sociological study of the leadership emergence, power psicology and the organizational oligarchical tendencies. In it all argumentation can be found on the ...

O EPÍLOGO DA TEORIA DOS DIREITOS FUNDAMENTAIS EM ROBERT ALEXY

OpenAIRE

Araújo Silveira, Whenry Hawlysson; Bruno da Silva, Alexandre Antônio

2014-01-01

Com o advento da Constituição Federal de 1988, foram implementados novos conceitos concernentes à Teoria do Direito por consequência de um fenômeno mundialmente conhecido como Neoconstitucionalismo. Uma destas mutações se dá por seu caráter axiológico e diz respeito à teoria dos direitos fundamentais. Robert Alexy inova seu pensamento a afirmar que o conflito entre direitos e garantias fundamentais deve ser resolvido pelo instituto da ponderação e afirma que esse instituto não se trata de um ...

Adaptación al idioma español de la escala del Penn State College of Medicine para medición del profesionalismo en estudiantes de medicina

Directory of Open Access Journals (Sweden)

Eliseo Bustamante

2014-06-01

Full Text Available Introducción. El profesionalismo es un área de interés en las facultades de medicina del mundo. El uso de un cuestionario puede ser útil para evaluar el profesionalismo en Colombia. Objetivo. Adaptar la escala de profesionalismo para estudiantes de medicina del Penn State University College of Medicine al idioma español como instrumento válido para evaluarlo. Materiales y métodos. Se siguieron las guías para adaptación de instrumentos del proyecto IQOLA, realizando traducción y traducción inversa, así como una prueba piloto y una evaluación de las características psicométricas en 250 estudiantes. Se evaluó la correlación entre ítems y escala y la validez interna con el alfa de Chronbach y se hizo un análisis factorial de componentes principales. Resultados. El alfa de Cronbach global fue de 0,86, la medida de Kaiser-Meyer-Olkin fue de 0,83 y el test de esfericidad de Bartlett tuvo un valor de p>0,00001. Se encontraron seis factores que explicaron 93 % de la varianza total y cuatro nuevos factores que emergieron del análisis factorial. Ocho ítems tuvieron alta singularidad. Conclusión. La escala del Penn State University College of Medicine mide con buen nivel de confiabilidad las actitudes hacia el profesionalismo en los estudiantes de medicina. No obstante, la estructura de la escala mostró diferencias al ser validada en estudiantes latinoamericanos.

Robert Hare's Theory of Galvanism: A Study of Heat and Electricity in Early Nineteenth-Century American Chemistry.

Science.gov (United States)

Fisher, Amy

2018-04-09

As a professor of chemistry at the University of Pennsylvania, Robert Hare actively shaped early American science. He participated in a large network of scholars, including Joseph Henry, François Arago, and Jacob Berzelius, and experimented with and wrote extensively about electricity and its associated chemical and thermal phenomena. In the early nineteenth century, prominent chemists such as Berzelius and Humphry Davy proclaimed that a revolution had occurred in chemistry through electrical research. Examining Robert Hare's contributions to this discourse, this paper analyzes how Hare's study of electricity and the caloric theory of heat led him to propose a new theory of galvanism. It also examines the reception of Hare's work in America and Great Britain, highlighting the contributions of early American chemists to the development of electrochemistry.

Penn State geoPebble system: Design,Implementation, and Initial Results

Science.gov (United States)

Urbina, J. V.; Anandakrishnan, S.; Bilen, S. G.; Fleishman, A.; Burkett, P.

2014-12-01

The Penn State geoPebble system is a new network of wirelessly interconnected seismic and GPS sensor nodes with flexible architecture. This network will be used for studies of ice sheets in Antarctica and Greenland, as well as to investigate mountain glaciers. The network will consist of ˜150 geoPebbles that can be deployed in a user-defined spatial geometry. We present our design methodology, which has enabled us to develop these state-of- the art sensors using commercial-off-the-shelf hardware combined with custom-designed hardware and software. Each geoPebble is a self- contained, wirelessly connected sensor for collecting seismic measurements and position information. Key elements of each node encompasses a three-component seismic recorder, which includes an amplifier, filter, and 24- bit analog-to-digital converter that can sample up to 10 kHz. Each unit also includes a microphone channel to record the ground-coupled airwave. The timing for each node is available from GPS measurements and a local precision oscillator that is conditioned by the GPS timing pulses. In addition, we record the carrier-phase measurement of the L1 GPS signal in order to determine location at sub-decimeter accuracy (relative to other geoPebbles within a few kilometers radius). Each geoPebble includes 16 GB of solid-state storage, wireless communications capability to a central supervisory unit, and auxiliary measurements capability (including tilt from accelerometers, absolute orientation from magnetometers and temperature). A novel aspect of the geoPebble is a wireless charging system for the internal battery (using inductive coupling techniques). The geoPebbles include all the sensors (geophones, GPS, microphone), communications (WiFi), and power (battery and charging) internally, so the geoPebble system can operate without any cabling connections (though we do provide an external connector so that different geophones can be used). We report initial field-deployment results and

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

Energy Technology Data Exchange (ETDEWEB)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

International Nuclear Information System (INIS)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple

Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

Science.gov (United States)

Jones, R. I. G.

2005-12-01

Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

Severe transient analysis of the Penn State University Advanced Light Water Reactor

International Nuclear Information System (INIS)

Borkowski, J.A.

1988-08-01

The Penn State University Advanced Light Water Reactor (PSU ALWR) incorporates various passive and active ultra-safe features, such as continuous online injection and letdown for pressure control, a raised-loop primary system for enhanced natural circulation, a dedicated primary reservoir for enhanced thermal hydraulic control, and a secondary shutdown turbine. Because of the conceptual design basis of the project, the dynamic system modeling was to be performed using a code with a high degree of flexibility. For this reason the modeling has been performed with the Modular Modeling System (MMS). The basic design and normal transients have been performed successfully with MMS. However, the true test of an inherently safe concept lies in its response to more brutal transients. Therefore, such a demonstrative transient is chosen for the PSU ALWR: a turbine trip and reactor scram, concurrent with total loss of offsite ac power. Diesel generators are likewise unavailable. This transient demonstrates the utility of the pressure control system, the shutdown turbine generator, and the enhanced natural circulation of the PSU ALWR. The low flow rates, low pressure drops, and large derivative states encountered in such a transient pose special problems for the modeler and for MMS. The results of the transient analyses indicate excellent performance by the PSU ALWR in terms of inherently safe operation. The primary coolant enters full natural circulation, and removes all decay heat through the steam generators. Further, the steam generators continually supply sufficient steam to the shutdown power system, despite the abrupt changeover to the auxiliary feedwater system. Finally, even with coincident failures in the pressurization system, the primary repressurizes to near-normal values, without overpressurization. No core boiling or uncovery is predicted, and consequently fuel damage is avoided. 17 refs., 19 figs., 4 tabs

CBO Testimony: Statement of Robert F. Hale, Assistant Director, National Security Division, Congressional Budget Office

National Research Council Canada - National Science Library

Hale, Robert F

1991-01-01

.... This testimony, by Robert F. Hale, Congressional Budget Office, covers the following topics: Socioeconomic Backgrounds of Enlisted Recruits, Racial Mix of Enlisted Recruits, Shifts in Recruiting during the 1980s, Altering the Composition of the Military: Reserve Mobilization and Conscription, and Should the Social Composition of the Military be a Concern?

Use of the modular modeling system in the design of the Penn State Advanced Light Water Reactor

International Nuclear Information System (INIS)

Smith, K.A.

1988-12-01

This study involves the design and subsequent transient analysis of the Penn State Advanced Light Water Reactor (PSU ALWR). The performance of the PSU ALWR is evaluated during small step changes in power and a turbine trip from full power without scram. The Modular Modeling System (MMS), developed by Babcock and Wilcox under a contract from the Electric Power Research Institute (EPRI), is a computer code designed for the simulation of nuclear and fossil power plants. MMS uses preprogrammed modules to represent specific power plant components such as pipes, pumps, steam generators, and a nuclear reactor. These components can then be connected in any manner the user desires providing certain simple interconnection rules are followed. In this study, MMS is used to develop computer models of both the PSU ALWR and a conventional PWR operating at the same power level. These models are then subjected to the transients mentioned above to evaluate the ability of the letdown-injection system to maintain primary system pressure. The transient response of the PSU ALWR and conventional PWR MMS models were compared to each other and whenever possible to actual plant transient data. 14 refs., 29 figs., 5 tabs

Effects of changes in pumping on regional groundwater-flow paths, 2005 and 2010, and areas contributing recharge to discharging wells, 1990–2010, in the vicinity of North Penn Area 7 Superfund site, Montgomery County, Pennsylvania

Science.gov (United States)

Senior, Lisa A.; Goode, Daniel J.

2017-06-06

A previously developed regional groundwater flow model was used to simulate the effects of changes in pumping rates on groundwater-flow paths and extent of recharge discharging to wells for a contaminated fractured bedrock aquifer in southeastern Pennsylvania. Groundwater in the vicinity of the North Penn Area 7 Superfund site, Montgomery County, Pennsylvania, was found to be contaminated with organic compounds, such as trichloroethylene (TCE), in 1979. At the time contamination was discovered, groundwater from the underlying fractured bedrock (shale) aquifer was the main source of supply for public drinking water and industrial use. As part of technical support to the U.S. Environmental Protection Agency (EPA) during the Remedial Investigation of the North Penn Area 7 Superfund site from 2000 to 2005, the U.S. Geological Survey (USGS) developed a model of regional groundwater flow to describe changes in groundwater flow and contaminant directions as a result of changes in pumping. Subsequently, large decreases in TCE concentrations (as much as 400 micrograms per liter) were measured in groundwater samples collected by the EPA from selected wells in 2010 compared to 2005‒06 concentrations.To provide insight on the fate of potentially contaminated groundwater during the period of generally decreasing pumping rates from 1990 to 2010, steady-state simulations were run using the previously developed groundwater-flow model for two conditions prior to extensive remediation, 1990 and 2000, two conditions subsequent to some remediation 2005 and 2010, and a No Pumping case, representing pre-development or cessation of pumping conditions. The model was used to (1) quantify the amount of recharge, including potentially contaminated recharge from sources near the land surface, that discharged to wells or streams and (2) delineate the areas contributing recharge that discharged to wells or streams for the five conditions.In all simulations, groundwater divides differed from

Flow visualization of three-dimensionality inside the 12 cc Penn State pulsatile pediatric ventricular assist device.

Science.gov (United States)

Roszelle, Breigh N; Deutsch, Steven; Manning, Keefe B

2010-02-01

In order to aid the ongoing concern of limited organ availability for pediatric heart transplants, Penn State has continued development of a pulsatile Pediatric Ventricular Assist Device (PVAD). Initial studies of the PVAD observed an increase in thrombus formation due to differences in flow field physics when compared to adult sized devices, which included a higher degree of three-dimensionality. This unique flow field brings into question the use of 2D planar particle image velocimetry (PIV) as a flow visualization technique, however the small size and high curvature of the PVAD make other tools such as stereoscopic PIV impractical. In order to test the reliability of the 2D results, we perform a pseudo-3D PIV study using planes both parallel and normal to the diaphragm employing a mock circulatory loop containing a viscoelastic fluid that mimics 40% hematocrit blood. We find that while the third component of velocity is extremely helpful to a physical understanding of the flow, particularly of the diastolic jet and the development of a desired rotational pattern, the flow data taken parallel to the diaphragm is sufficient to describe the wall shear rates, a critical aspect to the study of thrombosis and design of such pumps.

Validation of the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale.

Science.gov (United States)

Lodder, Wouter L; Adan, Guleed H; Chean, Chung S; Lesser, Tristram H; Leong, Samuel C

2017-06-01

The objective of this study is to evaluate the strength of content validity within the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale and to compare how it correlates with a facial dysfunction-specific QOL instrument (Facial Clinimetric Evaluation, FaCE). The study design is online questionnaire survey. Members of the British Acoustic Neuroma Association received both PANQOL questionnaires and the FaCE scale. 158 respondents with self-identified facial paralysis or dysfunction had completed PANQOL and FaCE data sets for analysis. The mean composite PANQOL score was 53.5 (range 19.2-93.5), whilst the mean total FaCE score was 50.9 (range 10-95). The total scores of the PANQOL and FaCE correlated moderate (r = 0.48). Strong correlation (r = 0.63) was observed between the PANQOL's facial dysfunction domain and the FaCE total score. Of all the FaCE domains, social function was strongly correlated with the PANQOL facial dysfunction domain (r = 0.66), whilst there was very weak-to-moderate correlation (range 0.01-0.43) to the other FaCE domains. The current study has demonstrated a strong correlation between the facial dysfunction domains of PANQOL with a facial paralysis-specific QOL instrument.

Science, Beliefs and Knowledge: A Personal Reflection on Robert J. Aumann’s Approach

OpenAIRE

Gil Kalai

2006-01-01

On the occasion of Robert J. Aumann's being awarded the 2005 Nobel Prize in Economics, this paper gives a personal view on some of Aumann's contributions, and primarily on his approach to foundational issues in game theory, economics, and science as a whole. It is based on numerous discussions and e-mail exchanges we had in the 1990's, dealing with various scientific and political matters, including our long debate on the ``Bible Code'' controversy.

Modification of Roberts' Theory for Rocket Exhaust Plumes Eroding Lunar Soil

Science.gov (United States)

Metzger, Philip T.; Lane, John E.; Immer, Christopher D.

2008-01-01

Roberts' model of lunar soil erosion beneath a landing rocket has been updated in several ways to predict the effects of future lunar landings. The model predicts, among other things, the number of divots that would result on surrounding hardware due to the impact of high velocity particulates, the amount and depth of surface material removed, the volume of ejected soil, its velocity, and the distance the particles travel on the Moon. The results are compared against measured results from the Apollo program and predictions are made for mitigating the spray around a future lunar outpost.

Robert Molesworth's An Account of Denmark as it was in 1692

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2008-01-01

Robert Moleswort's An Account of Denmark as it was in 1692 is a violent political pamphlet in the early British Whig-tradition aimed at underscoring republican values by pointing to the dreadful example of Danish Absolutist slavery. It was a bestseller on an international scale. In his book...... of these was Ludvig Holberg's Description of Denmark and Norway (1729) which counters Molesworth on the basis of history and natural law - and in a witty style. Thus the republican manifesto of Molesworth became instrumental in shaping the political outlook and language of the very moderate, loyal and anything...

Justice, Integrity and Fairness: Relevant Questions About Robert Nozick Political Theory

Directory of Open Access Journals (Sweden)

Carlos Fernando Cruz da Silva

2016-11-01

Full Text Available The present work develops and analysis about Robert Nozick political theory based in thesis defended by Ronald Dworkin. The central objective of this paper is to investigate the validity or the invalidity of the justice principles proposed by Nozick under the integrity theory. The methodology utilized to construct the definitive hypothesis was based, initially, in a theoretical search, developed through of an bibliographical lifting of the principal involved authors texts. After the survey, a descriptive analysis of the texts was executed and, then, was executed and critical analysis. At the end, an definitive proposal was constructed with an deductive reasoning.

Contemporary Hegelian Scholarship: Robert Stern’s Holistic Reading of Hegel

Directory of Open Access Journals (Sweden)

Paniel Reyes Cardenas

2015-12-01

Full Text Available This is a monographic presentation in which the author depicts the guidelines of Professor Robert Stern’s interpretation of Hegelian Metaphysics by emphasizing in its characteristic holistic reading. The proposal is that some key fundamental topics of Hegelian scholarship will emerge with a clarified understanding after this reading: the concept of Truth and absolute knowledge are reassessed by showing the necessary connection of Epistemology and Metaphysics in Hegel. Hegelian Metaphysics, accordingly, appears ultimately as the principle for a reading of Hegel’s entire philosophy and illuminates its nature of general metaphysical inquiry. Finally, this reading allows drawing on the connection of Hegel’s Idealism with the Pragmatist tradition initiated by Peirce.

Fermilab's Helen Edwards receives prestigious 2003 Robert R. Wilson prize from the American Physical Society

CERN Multimedia

2002-01-01

Helen Edwards has been awarded the 2003 Robert R. Wilson prize. She was cited for "her pivotal achievement and critical contribution as the leader in the design, construction, commissioning and operation of the Tevatron, and for her continued contributions to the development of high gradient superconducting linear accelerators as well as bright and intense electron sources." (1/2 page).

Preliminary Normative Data on the Penn State University Symbol Cancellation Task With Nonconcussed Adolescents.

Science.gov (United States)

Conder, Robert L; Conder, Alanna A; Register-Mihalik, Johna; Conder, Lauren H; Newton, Shannon

2015-01-01

Visual concentration impairment after neurologic injury is frequent, making its identification a critical component of neurocognitive concussion assessment. Visual target cancellation tests such as the Penn State University Symbol Cancellation Task (PSUSCT) have been widely used in assessing professional and collegiate athletes. To date, there are no normative studies using the PSUSCT with an adolescent population. Given that 38 million children and adolescents participate in sports and an estimated 5% to 10% are concussed annually, adolescent normative data are critically needed to evaluate concussions in this vulnerable population. The purpose of this study was to provide adolescent normative data on the PSUSCT. Participants included 40 healthy, nonconcussed high school students aged 14 to 19 years old (20 men, 20 women). Participants were administered Forms A and C of the PSUSCT within a 4-day period. Data analysis examined hits, omission errors, and commission errors, with descriptive statistics calculated for the total sample and for subgroups by gender and age. Study 1 provided normative adolescent data on Form A. Study 2 examined practice effects and established reliable change indexes (RCIs) by comparing results on Forms A and C. Neither Study 1 nor Study 2 demonstrated significant group differences for gender or age. In conclusion, this study presents adolescent normative data, apparent practice effects, and RCIs on the PSUSCT. These norms provide data needed to appropriately include the PSUSCT in baseline and postinjury concussion evaluation batteries with adolescent student-athletes. Findings should be replicated with a larger, more heterogeneous sample.

Business ethics and virtue: on Robert C. Solomon's many ways of being ethical.

OpenAIRE

Gallego Salvador, Francisco

2013-01-01

The present Thesis explores the possibility of applying a virtue ethics framework, based upon the Aristotelian tradition, into business ethics. The purpose of the Thesis is twofold: to give an overview of virtue ethics through Richard Taylor’s portrait and to offer a specific account of virtue ethics focused on the business realm. The examination of this virtue ethics proposal is largely founded on Robert C. Solomon’s works, which constitute the cornerstone of this Thesis. However, the critic...

A gift of prophecy essays in celebration of the life of Robert Eugene Marshak

CERN Document Server

1994-01-01

Robert Eugene Marshak (1916-92) devoted much of his life to helping other people carry out scientific research and gather to discuss their work. In addition to his scientific statesmanship, he was an extraordinarily gifted research scientist, and many of his scientific contributions have been prophetic. This book pays homage to his creativity and continuing work, with contributions from many of the people whose lives have been influenced by him.

Validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) for Spanish-Speaking Patients.

Science.gov (United States)

Medina, Maria Del Mar; Carrillo, Alvaro; Polo, Ruben; Fernandez, Borja; Alonso, Daniel; Vaca, Miguel; Cordero, Adela; Perez, Cecilia; Muriel, Alfonso; Cobeta, Ignacio

2017-04-01

Objective To perform translation, cross-cultural adaptation, and validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) to the Spanish language. Study Design Prospective study. Setting Tertiary neurotologic referral center. Subjects and Methods PANQOL was translated and translated back, and a pretest trial was performed. The study included 27 individuals diagnosed with vestibular schwannoma. Inclusion criteria were adults with untreated vestibular schwannoma, diagnosed in the past 12 months. Feasibility, internal consistency, test-retest reliability, construct validity, and ceiling and floor effects were assessed for the present study. Results The mean overall score of the PANQOL was 69.21 (0-100 scale, lowest to highest quality of life). Cronbach's α was 0.87. Intraclass correlation coefficient was performed for each item, with an overall score of 0.92. The κ coefficient scores were between moderate and almost perfect in more than 92% of patients. Anxiety and energy domains of the PANQOL were correlated with both physical and mental components of the SF-12. Hearing, balance, and pain domains were correlated with the SF-12 physical component. Facial and general domains were not significantly correlated with any component of the SF-12. Furthermore, the overall score of the PANQOL was correlated with the physical component of the SF-12. Conclusion Feasibility, internal consistency, reliability, and construct validity outcomes in the current study support the validity of the Spanish version of the PANQOL.

The Aspiring Adept: Robert Boyle and His Alchemical Quest (Lawrence M. Principe)

Science.gov (United States)

Kovac, Jeffrey

1999-10-01

Robert Boyle is widely regarded as the Father of Modern Chemistry, who broke once and for all from the irrational, misguided alchemy that preceded him. One of the goals of this carefully researched and argued new book by Lawrence M. Principe, Assistant Professor in the Department of Chemistry and the Institute for the History of Science, Medicine, and Technology at The Johns Hopkins University, is to refute the two errors in this characterization of Boyle and to understand his life, thought, and work in the intellectual and social context of his time. This book is not for the casual reader; it is a detailed scholarly treatise in the history of science, but it provides a fresh and interesting perspective on Boyle and on the development of chemistry in the 17th century. Boyle is usually characterized as a modern scientist and his most famous book, The Skeptical Chymist, as a critique of traditional alchemy. Principe demonstrates that this characterization is based on a selective and sometimes incorrect reading of Boyle's works. Like Newton, Boyle was deeply involved in traditional transmutational alchemy, reading the works of other alchemists, performing experiments, and even witnessing transmutations. Alchemy, however, was not a monolith and Boyle adhered to what Principe tentatively identifies as a uniquely English school of supernatural alchemy. According to Principe, The Skeptical Chymist was mainly a criticism of the Paracelsians interested in chemical medicine rather than a defense of what we would now regard as modern chemistry. To further support his characterization of Boyle and to better reveal Boyle's involvement in alchemyparticularly the transmutation of base metals to gold, termed chrysopoeiaPrincipe has reconstructed from some 20 fragments one of Boyle's alchemical manuscripts, his Dialogue on the Transmutation of Metals. The full text of this lost work is included as Appendix 1. Two other primary sources, Interview Accounts of Transmutations and

Robert Schumann and translation: poetic creativity, simultaneity and movement

Directory of Open Access Journals (Sweden)

João Azenha Junior

2012-07-01

Full Text Available In diesem Aufsatz werden die Gesammelten Schriften über Musik und Musiker von Robert Schumann untersucht, insbesondere die Rezensionen, die der Komponist zwischen 1834 und 1836 verfasst hat. Es soll festgestellt werden, inwiefern sich darin die wichtigsten Auffassungen über Sprache und Übersetzung, die Ende des 18. und Beginn des 19. Jahrhunderts in Deutschland entstanden, wiederfinden. Im Vordergrund der Untersuchung steht die Dimension der Bewegung, die sich sowohl im Individuum als auch in der Zeit festmachen lässt. Im Individuum manifestiert sich die Bewegung als ein sehr persönlicher Vorgang, da es sich innerhalb verschiedener Zeichensysteme bewegt, die seine Gedanken ausdrücken; oder aber es bewegt sich innerhalb verschiedener Sprachen. Die Zeitdimension wiederum bedeutet, in ein Umfeld einzutauchen, das die Zeitbarrieren überwindet und die Vergangenheit auf einen Schlag mit der Gegenwart und der Zukunft verbindet.

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.

Science.gov (United States)

Rainsford, K D; Haynes, D R

2013-08-01

This issue of Inflammopharmacology contains papers that have been submitted to commemorate the life and work of Professor Barrie Vernon-Roberts, an outstanding clinical scientist in the field of bone pathology and its pharmacological regulation. This review briefly summarizes his major works and achievements as well as a list of his publications.

Field building: lessons from the Robert Wood Johnson Foundation's anthology series.

Science.gov (United States)

Isaacs, Stephen L; Knickman, James R

2005-01-01

As editors of the Robert Wood Johnson Foundation's (RWJF's) anthology series, we have examined the entire range of the foundation's grant making since 1972. We found that the RWJF has enjoyed considerable success in building fields--from nurse practitioners to tobacco control to end-of-life care. The RWJF has done this by shaping fields as they were emerging, by adopting a wide-ranging "bear hug" approach, and by staying the course. The lessons from the RWJF's field-building efforts are relevant for both large and small foundations: Small funders can develop strategic plans aimed at building fields in their home state or locality.

Brasil, estudos pós-coloniais e contracorrentes análogas: entrevista com Ella Shohat e Robert Stam

NARCIS (Netherlands)

dos Santos, E.R.S.; Schor, P.

2013-01-01

Interview with Ella Shohat and Robert Stam (Portuguese translation). Original version: Brazil is not Traveling Enough”: On Postcolonial Theory and Analogous Counter-Currents (http://www2.let.uu.nl/solis/psc/P/PVOLUMEFOUR/PVOLUMEFOURPAPERS/P4SHOHAT-STAM-INTERVIEW.pdf)

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

OpenAIRE

Meza, Anibal; Lazarte, Carmen

2013-01-01

The authors review fundamental aspects of Robert Gagné's Leaming Theory, highlighting its philosophical (positivism and pragmatism) and scientific bases (behaviorism and information processing). Using an epistemological framework, these aspects are assessed in terrns of its theoretical and topical validity, as well as its technical efficiency. It is concluded that Gagné's Theory is eclectic and that its scientific contribution is taxonomic. It represents a theoretical model rather than a theo...

Kevad inglise kunstielus

Index Scriptorium Estoniae

2000-01-01

Tate Gallery uus avamine 24. III Londonis. Tate Britain'ile lisandub Tate Modern (avamine mais). Londoni kaasaegse kunsti galeriis Serpentine jaapani kunstniku Yayoi Kusama isiknäitus. Leedsi Linna Kunstigaleriis inglise kunstniku Eileen Agari (1899-1991) retrospektiivnäitus

Londoni jõujaamast sai moodsa kunsti muuseum / Tambet Kaugema

Index Scriptorium Estoniae

Kaugema, Tambet

2000-01-01

Moodsa kunsti muuseum Tate Modern sisaldab 20. saj. kunsti. Tate Britaini (seni Tate Gallery) jääb inglise kunst. Ümberehituse projekti tegid šveitsi arhitektid Jacques Herzog ja Pierre de Meuron. Jõujaama projekteeris Sir Giles Gilbert Scott

Der Schurke ist kein Schurke mehr. Form und Rollenkonzeption in Robert Walsers "Schneewittchen"

OpenAIRE

Ochoa Savic, Tania

2015-01-01

Robert Walser (1878-1956) fue un escritor suizo que permaneció en el olvido durante décadas tanto para los lectores como para la crítica literaria. Siendo aún joven publicó varias obras como "Schneewittchen" (1901) y "Aschenbrödel" (1901) en revistas renombradas como Die Insel, pero sin llegar a alcanzar la fama literaria. Por otro lado, también intentó, durante su estancia en Stuttgart, probar suerte en el mundo del teatro como actor, mientras trabajaba como oficinista para p...

The Poetry of Robert Burns: “A Melancholy not unallied to Mirth.”

Directory of Open Access Journals (Sweden)

Karyn COSTA

2006-06-01

Full Text Available When Allan Cunningham concluded his 1834 Life of Burns with this critical judgement of Robert Burns’s poetry he was in fact summing up the schizophrenic nature of the Scottish character and identity. Scottish duality is still prevalent in the Highland-Lowland divide, the Catholic-Protestant rivalry, the linguistic differences Scots versus Gaelic, the English and Scottish competition for power, the past battling with the present in the search for a national identity free from myth and a sense ...

Negotiating Primitivist Modernisms: Louis Armstrong, Robert Goffin, and the Transatlantic Jazz Debate

Directory of Open Access Journals (Sweden)

Daniel Stein

2011-10-01

Full Text Available “Dear Pal Goffin,” Louis Armstrong wrote to his Belgian acquaintance, the lawyer, hobby journalist, and jazz historian Robert Goffin, on July 19, 1944. “‘Man—I’ve been trying to get in touch with you […]. Here’s another hundred dollars toward the five hundred. […] So accept this hundred and I’ll send the other before a ‘Black Cat can ‘Lick his ‘Bu‘hind’ ….. haw haw haw…” (80. Sending Goffin a batch of money along with this playfully worded missive, Armstrong was hoping for quick results. He ...

Quotation. Paratext and Romantic Orientalism: Robert Southey's "The Curse of Kehama" (1810

Directory of Open Access Journals (Sweden)

Ourania Chatsiou

2010-12-01

Full Text Available To a considerable extent, Romantic Orientalist literature is founded on scholasticism, authentication, quotation of antiquarian sources, in other words, on paratext. It constitutes in many respects an oxymoronic, though fascinating and dynamic, symbiosis of repetition / replication and creative imagination / invention. By focusing on Robert Southey’s art of quotation in his extraordinarily abundant notes to his orientalist narrative verse this essay seeks to establish paratext as an integral, formative aspect of Romantic Orientalism and Romantic-period poetics, illustrating the hybridity of the Romantic genius and Romantic poetic creation, and challenging common assumptions about a sublime, universal Romantic-period poetry.

Robert Heath Lock and his textbook of genetics, 1906.

Science.gov (United States)

Edwards, A W F

2013-07-01

Robert Heath Lock (1879-1915), a Cambridge botanist associated with William Bateson and R. C. Punnett, published his book Recent Progress in the Study of Variation, Heredity, and Evolution in 1906. This was a remarkable textbook of genetics for one appearing so early in the Mendelian era. It covered not only Mendelism but evolution, natural selection, biometry, mutation, and cytology. It ran to five editions but was, despite its success, largely forgotten following Lock's early death in 1915. Nevertheless it was the book that inspired H. J. Muller to do genetics and was remembered by A. H. Sturtevant as the source of the earliest suggestion that linkage might be related to the exchange of parts between homologous chromosomes. Here we also put forward evidence that it had a major influence on the statistician and geneticist R. A. Fisher at the time he was a mathematics student at Cambridge.

Study, Stance, and Stamina in the Research on Teachers' Lives: A Rejoinder to Robert V. Bullough, Jr.

Science.gov (United States)

Kelchtermans, Geert

2008-01-01

Robert V. Bullough, Jr.'s article demonstrated in an impressive way how autobiographical accounts, as well as single person narratives, are intertwined with much larger issues in society, international politics, and economical interests, as well as consequences for people in general and educators in particular. The way he proves capable of…

Kunstijaam jõe ääres / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

2000-01-01

Külaskäik 14. V avatud moodsa kunsti muuseumi Tate Moderni Londonis. 1937. a. ehitatud Bankside'i elektrijaama (arhitekt G. G. Scott) rekonstruktsioon. Arhitektid J. Herzog ja P. de Meuron. Ehitamisel N. Fosteri projekteeritud muuseumi St. Pauli katedraaliga ühendav jalakäijate sild. Näitusest "Between Cinema and Hard Place". Tate Moderni ja Tate Britaini ekspositsiooni süsteemist. M. Hatoumi töödest Tate Britainis. Mida võiks Londoni näide meile õpetada?

Work and vulnerability: the social question on Robert Castel’s thought

Directory of Open Access Journals (Sweden)

Fabrício Maciel

2015-02-01

Full Text Available The article emphasizes the centrality of the concept of work in the thought of the French sociologist Robert Castel. Despite being best known in Brazil for his concepts of social question and social disaffiliation, the concept of work is crucial in the articulation of the author's thought, notably in his latest writing. The article is divided into four parts. First, it provides a general introduction to the work of Castel. Then, it demonstrates how work can be considered the main social question of contemporary global capitalism. Following, it resumes the relationship between work and social vulnerability. The study concludes by pointing out the importance of understanding work as the main contemporary social issue.

Automatic program development a tribute to Robert Paige

CERN Document Server

Danvy, Olivier; Mairson, Harry; Pettorossi, Alberto

2008-01-01

This work, a tribute to renowned researcher Robert Paige, is a collection of revised papers published in his honor in the Higher-Order and Symbolic Computation Journal in 2003 and 2005.Among them there are two key papers: a retrospective view of his research lines, and a proposal for future studies in the area of the automatic program derivation.The book also includes some papers by members of the IFIP Working Group 2.1 of which Bob was an active member.All of the papers are related to the research interests of Dr Paige, who died in 1999, and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications.His colleagues, who include Olivier Danvy of the University of Aarhus in Denmark, and Alberto Pettorossi of the University of Rome 'Tor Vergata' in Italy, believe the book provides a renewed stimulus for continuing and deepening Dr Paige's research vision.Prof. Olivier Danvy is editor in chief of the Higher Order for Symbolic Computation journal.

Between genres and styles in the films of Robert Bresson

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Luíza Beatriz Alvim

2016-02-01

Full Text Available The films of French director Robert Bresson are considered sober and transcendental. However, in A gentle woman (1969 and in Four nights of a dreamer (1972, he included extracts of quite different genres, like a libertine comedy (the extract of film Benjamim by Michel Deville, 1968, a Shakespearean tragedy (a performance of Shakespeare´s Hamlet and a gangster film (When love possesses us, produced by Bresson himself. In a way, those excerpts represent exactly the opposite of Bresson´s cinema. On the other hand, they still have some familiarity with it. We analyze the approach of those genres in the sequences in Bresson´s films, as well of the styles present in them by the use of music and images of paintings.

The South Pacific in the works of Robert Dean Frisbie

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Nataša Potočnik

2001-12-01

In Tahiti he had ambitious writing plans but after four years of living in Tahiti, he left his plantation and sailed to the Cook Islands. He spent the rest of his life in the Cook Islands and married a local girl Ngatokorua. His new happiness gave him the inspiration to write. 29 sketches appeared in the United States in 1929, collected by The Century Company under the title of The Book of Puka-Puka. His second book My Tahiti, a book of memories, was published in 1937. After the death of Ropati 's beloved wife his goals were to bring up his children. But by this time Frisbie was seriously ill. The family left Puka-Puka and settled down on the uninhabited atoll of Suwarrow. Later on they lived on Rarotonga and Samoa where Frisbie was medically treated. Robert Dean Frisbie died of tetanus in Rarotonga on November 18, 1948. Frisbie wrote in a vivid, graceful style. His characters and particularly the atoll of Puka-Puka are memorably depicted. Gifted with a feeling for language and a sense of humor, he was able to capture on paper the charm, beauty, and serenity of life of the small islands in the South Pacific without exaggerating the stereotypical idyllic context and as such Frisbie's contribution to South Pacific literature went far deeper than that of many writers who have passed through the Pacific and wrote about their experiences. Frisbie's first book The Book of Puka-Puka was published in New York in 1929. It is the most endearing and the most original of his works. It was written during his lifetime on the atoll Puka-Puka in the Cook Islands. It is a collection of 29 short stories, episodic and expressively narrative in style. This is an account of life on Puka-Puka that criticizes European and American commercialism and aggressiveness, and presents the themes of the praise of isolation, the castigation of missionaries, and the commendation of Polynesian economic collectivism and sexual freedom. At the same time, the book presents a portrait of Frisbie himself

[Robert Koch, eminent medical bacteriologist, creator of the applied microbiology and its technnology].

Science.gov (United States)

Suárez Fernández, Guillermo

2012-01-01

In our communication we wish consider to bring at a first instance the egregious figure of Robert Koch a hundred of years after his dead. Nobody else had contributed so much in the development of the bacteriology as unic and independent science. Several books and biographical sketchs had been published about Koch in german, english and french, mainly, with differents detais and interpretations, about his life. However, nobody doubred about his innovator spirit and scientist at highest level. This communication revise and discuss diverse chapters about his life as innovator, researcher, groups leader and Magister.

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity

DEFF Research Database (Denmark)

Gordillo, M.; Vega, H.; Trainer, A.H.

2008-01-01

Roberts syndrome/SC phocomelia (RBS) is an autosomal recessive disorder with growth retardation, craniofacial abnormalities and limb reduction. Cellular alterations in RBS include lack of cohesion at the heterochromatic regions around centromeres and the long arm of the Y chromosome, reduced growth...... and nonsense mutations associated with decreased levels of mRNA and absence of protein. We found decreased proliferation capacity in RBS cell lines associated with cell death, but not with increased cell cycle duration, which could be a factor in the development of phocomelia and cleft palate in RBS...

DIRECTOR/PRODUCER ROBERT ZEMECKIS DURING FILMING OF 'CONTACT' AT LC39 PRESS SITE

Science.gov (United States)

1997-01-01

Robert Zemeckis, director/producer, and other Warner Bros. crew members oversee the filming of scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

The dilemmas of indefiniteness: Utopia, fluidity and subjectivity in Stone, by Adam Roberts

OpenAIRE

André Cabral de Almeida Cardoso; Carla de Figueiredo Portilho

2017-01-01

http://dx.doi.org/10.5007/2175-8026.2017v70n2p107 Ae, the narrator-protagonist of the novel Stone, by Adam Roberts, is the only criminal in a post-human utopian society in which the use of nanotechnology has allowed humanity to reach its plenitude. Isolated from the rest of society, one day Ae is offered freedom and wealth if he agrees to kill the population of a whole planet. After accepting this offer, Ae must try to fulfil his mission at the same time that he questions himself and trie...

A diagnosis of modern life: Robert Musil’s Der Mann ohne Eigenschaften as a critical-utopian project

NARCIS (Netherlands)

de Cauwer, S.

2012-01-01

Robert Musil wrote Der Mann ohne Eigenschaften as a critical intervention in the intellectual debates of his time. There are three general questions which prevail in the Musil scholarship: 1. What exactly did he want to critique and how is this critique at work in the novel? 2. What were his aims

LOS DERECHOS FUNDAMENTALES COMO NORMAS JURÍDICAS MATERIALES EN LA TEORÍA DE ROBERT ALEXY

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María Dolores Pérez Jaraba

2011-12-01

Full Text Available RESUMEN. La teoría de los derechos fundamentales de Robert Alexy se fundamenta en un concepto material de norma jurídica que es de carácter doble. Por un lado, se define por los rasgos propios de los principios, en consonancia con la idea de argumentación correcta. Pero, por otro lado, sigue teniendo peso la validez jurídica de las normas que contienen derechos fundamentales, consideradas como reglas constitucionales. Tal y como se argumenta en el trabajo, esta ambigüedad de la teoría de la norma de Alexy permite distintos acercamientos, positivistas y no positivistas, que es signo de su riqueza teórica. ABSTRACT. The theory of the civil rights of Robert Alexy is based on a material concept of rule of law. It is two-fold. On the one hand, is defined by the traits of the principles, consistent with the idea of ??correct argument. But on the other hand, weight is still the legal validity of the rules contained civil rights, constitutional rules considered. As argued in the work, this ambiguity of the norm theory allows for different approaches Alexy, positivist and positivist, which is a sign of its theoretical richness

Charles Robert Darwin and Alfred Russel Wallace: their dispute over the units of selection.

Science.gov (United States)

Ruse, Michael

2013-12-01

Charles Darwin and Alfred Russel Wallace independently discovered the mechanism of natural selection for evolutionary change. However, they viewed the working of selection differently. For Darwin, selection was always focused on the benefit for the individual. For Wallace, selection was as much something of benefit for the group as for the individual. This difference is traced to their different background political-economic views, with Darwin in favor of Adam Smith's view of society and Wallace following Robert Owen in being a socialist.

Robert J. Flaherty and Seáinín Tom Ó Dioráin: Lights, Camera, and (Not Too Much Action

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Tomás Ó h-Íde (Ihde

2016-03-01

Full Text Available Famed director Robert Flaherty’s first direct sound film, Oidhche Sheanchais, was recently discovered at Harvard University. This article discusses the impact that the discovery will have on our understanding of this short film, especially as concerns film studies and folklore. It notes several misunderstandings reported in the literature over the years that have now been set right with the finding of the film. The article points to resources held in archives in Ireland and the United States that can additionally address questions related to this film. While a noteworthy contribution to the filmography of Robert Flaherty, the short ‘talkie’ must be approached with caution by folklorists due to the coaching of actors and cinematographic editing.

Accuracy evaluation of pendulum gravity measurements of Robert von Sterneck

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Alena Pešková

2015-06-01

Full Text Available The accuracy of first pendulum gravity measurements in the Czech territory was determined using both original surveying notebooks of Robert Daublebsky von Sterneck and modern technologies. Since more accurate methods are used for gravity measurements nowadays, our work is mostly important from the historical point of view. In previous  works, the accuracy of Sterneck’s gravity measurements was determined using only a small dataset. Here we process all Sterneck’s measurements from the Czech territory (a dataset ten times larger than in the previous works, and we complexly assess the accuracy of these measurements. Locations of the measurements were found with the help of original notebooks. Gravity in the site was interpolated using actual gravity models. Finally, the accuracy of Sterneck’s measurements was evaluated as the difference between the measured and interpolated gravity.

CRAFTING THE MICROWORLD: HOW ROBERT HOOKE CONSTRUCTED KNOWLEDGE ABOUT SMALL THINGS.

Science.gov (United States)

Lawson, Ian

2016-03-20

This paper investigates the way in which Robert Hooke constructed his microscopical observations. His Micrographia is justifiably famous for its detailed engravings, which communicated Hooke's observations of tiny nature to his readers, but less attention has been paid to how he went about making the observations themselves. In this paper I explore the relationship between the materiality of his instrument and the epistemic images he produced. Behind the pictures lies an array of hidden materials, and the craft knowledge it took to manipulate them. By investigating the often counter-theoretical and conflicting practices of his ingenious microscope use, I demonstrate the way in which Hooke crafted the microworld for his readers, giving insight into how early modern microscopy was understood by its practitioners and audience.

Robert Beuka. American Icon: Fitzgerald’s The Great Gatsby in Critical and Cultural Context.

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Theodora Tsimpouki

2012-02-01

Full Text Available What new can another critical study on F. Scott Fitzgerald’s The Great Gatsby contribute to the already existing abundance of books concerning this national classic?  Yet, in this slim and elegant volume, Robert Beuka has managed to encompass not only the formal scholarship on Gatsby but also a complete and thorough survey of the impact of the novel into the world of popular culture. This parallel attempt throws light on the changing modes of interpretation that have affected our understandin...

Abstract – IT Robert Lepage: anatomia di un regista

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Giulio Boato

2012-01-01

Full Text Available Abstract – ITRobert Lepage è uno dei registi più rilevanti del panorama teatrale internazionale contemporaneo. L’articolo cerca di fornire una sintetica analisi della poetica del regista soffermandosi in particolar modo sulle nozioni di “montaggio” e di “immagine” al fine di definire il rapporto tra tecnologia e linguaggio in teatro. L’analisi di due spettacoli di Lepage presentati in occasione del Napoli Teatro Festival Italia(edizioni 2010 e 2011 alimenta la riflessione teorica che si snoda seguendo una metafora anatomica:analizzare separatamente (sezionando come il chirurgo le varie componenti narrative e formali del modus operandi lepagiano permette di comprendere più agevolmente l’architettura organica dell’insieme Abstract – FR Robert Lepage est un des metteurs en scène les plus remarqués de la scène théâtrale internationale contemporaine. L’article cherche à fournir une analyse synthétique de l’art poétique du metteur en scèneen se concentrant en particulier sur les notions de « montage » et « image » afin d’en définir le rapportentre technologie et langage au théâtre. L’analyse de deux spectacles de Lepage présentés pendant leNapoli Teatro Festival Italia (éditions 2010 et 2011 alimente la réflexion théorique qui se développeselon une métaphore anatomique : à la manière d'un chirurgien disséquant un corps, on analyseraséparément les différentes composantes narratives et formelles utilisées par Lepage afin de comprendreplus facilement l’architecture organique de l’ensemble. Abstract – EN Robert Lepage is one of the most significant directors on the international and contemporary theatrescene. The article tries to provide a synthetic analysis of the director’s work: focusing on the notions of “editing” and “image”, it defines the relation between technology and language in theatre. The analysis oftwo pieces of theatre presented at the Napoli Teatro Festival Italia

David Roberts en Córdoba. Vistas de paisaje y arquitectura hacia 1833

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Gámiz Gordo, Antonio

2015-12-01

Full Text Available David Roberts' views of Córdoba were carried out in 1833 and later redrafted as lithographs, engravings, and oils. These artworks enjoyed great commercial success and international diffusion due to their thematic and undoubted artistic value. The authors analyze their documentary value as a graphic record -prior to the advent of photography- of the urban landscape and architecture of Cordoba, a city now denominated a World Heritage Site. These images are studied here for the first time as a group, since they are either virtually untraceable or dispersed in museums throughout the world. In addition, these views have been contextualized with information concerning the artist and his Spanish journey, including a letter that he wrote from Córdoba. The documentary reliability of every image is also assessed, while the significant transformations of the places represented are indicated.Las vistas realizadas en Córdoba por David Roberts en 1833, reelaboradas como litografías, grabados y óleos, han gozado de gran éxito comercial y difusión internacional por su temática e indudable interés artístico. Esta investigación profundiza en su valor documental como registros gráficos previos a la aparición de la fotografía, del paisaje y la arquitectura de una ciudad hoy considerada Patrimonio de la Humanidad. Las imágenes presentadas se analizan por primera vez como conjunto, pues algunas son de difícil localización o están dispersas en museos de todo el mundo, y se contextualizan con datos sobre el pintor y su viaje por España, considerando una carta que éste escribió desde Córdoba. También se valora la fiabilidad documental de cada vista, a la vez que se detectan significativas transformaciones de los lugares representados.

Kas noore õpetaja lähtetoetus motiveerib maakooli minema? / Robert Ossipov, Kerstin Kirmjõe, Liina Lüüs...[jt.

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastasid TLÜ õpetajakoolituse magistriõppe üliõpilane Robert Ossipov, TÜ üliõpilane Kerstin Kirmjõe, Tartu Mart Reiniku gümnaasiumi sotsiaalpedagoog Liina Lüüs, Tapa gümnaasiumi füüsikaõpetaja Henrik Sova, TÜ üliõpilane Ott Maidre

Robert L. Oprisko’s Honor: A Phenomenology and Holden Caulfield

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Eliza Quincey

2015-07-01

Full Text Available Robert L. Oprisko’s book, “Honor: A Phenomenology” challenges ones of the most obvious social norms in contemporary society. The concept of honor is one that the “generic” as Sergei Prozorov would say, simply cannot comprehend, nor even make efforts to define. Though fluently used in infamous works such as “The Iliad”, honor has yet to be so explicitly dissected until now. Dr. Oprisko’s book takes a promiscuous and brutally honest approach to “Honor” en generale as well as the many facets associated with such. Similar to fine cuisine and wine, there are many literary accompaniments that serve as wonderful pairings to broaden the kaleidoscope perspectives presented in the book. The contested novel by J.D. Salinger, “The Catcher in the Rye”, although by no means consists of any political or metaphysical theory, contains a stark personification of what is actively presented in every chapter of Dr. Oprisko’s book. Holden Caufield serves as a terrific litmus test for the concepts defined in Oprisko’s work. Holden is by no means a likeable character in the literary world, but however he is raw enough to be able to internalize and beholden things like, “honorableness”, “dignity”, and most importantly for Holden, “face”. Though to the naked eye and untrained mind these “things” which Holden can in fact internalize may seem fairly simple; it challenges the reader to humble oneself and accept that which is the raw. There is no space for semantics and lies in Oprisko’s work. In fact it is so shockingly explicit, one may find themselves utterly offended. Holden Caufield offended readers for years after Sallinger brought him to life over the span of 200 or more so pages, so much that the book was condemned in certain places. Robert L. Oprisko’s, “Honor: A Phenomenology”, in my utmost opinion, contains this same potential. By critically engaging in Oprisko’s spar with “honor”, one may find themselves

Topics in mathematical economics and game theory essays in honor of Robert J. Aumann

CERN Document Server

Wooders, Myrna H

1999-01-01

Since the publication of Theory of Games and Economic Behavior by von Neumann and Morgenstern, the concept of games has played an increasing role in economics. It also plays a role of growing importance in other sciences, including biology, political science, and psychology. Many scientists have made seminal advances and continue to be leaders in the field, including Harsanyi, Shapley, Shubik, and Selten. Professor Robert Aumann, in addition to his important contributions to game theory and economics, made a number of significant contributions to mathematics. This volume provides a collection

Use of social media in graduate-level medical humanities education: two pilot studies from Penn State College of Medicine.

Science.gov (United States)

George, Daniel R; Dellasega, Cheryl

2011-01-01

Social media strategies in education have gained attention for undergraduate students, but there has been relatively little application with graduate populations in medicine. To use and evaluate the integration of new social media tools into the curricula of two graduate-level medical humanities electives offered to 4th-year students at Penn State College of Medicine. Instructors selected five social media tools--Twitter, YouTube, Flickr, blogging and Skype--to promote student learning. At the conclusion of each course, students provided quantitative and qualitative course evaluation. Students gave high favourability ratings to both courses, and expressed that the integration of social media into coursework augmented learning and collaboration. Others identified challenges including: demands on time, concerns about privacy and lack of facility with technology. Integrating social media tools into class activities appeared to offer manifold benefits over traditional classroom methods, including real-time communication outside of the classroom, connecting with medical experts, collaborative opportunities and enhanced creativity. Social media can augment learning opportunities within humanities curriculum in medical schools, and help students acquire tools and skill-sets for problem solving, networking, and collaboration. Command of technologies will be increasingly important to the practice of medicine in the twenty-first century.

Versiones transgresoras y polémicas de Blancanieves: de Robert Walser a João César Monteiro

OpenAIRE

García-Manso, Angélica

2017-01-01

Este artículo analiza dos versiones heterodoxas del cuento de hadas Blancanieves: de un lado, la obra de teatro homónima escrita en 1901 por el suizo Robert Walser; y de otro, la película dirigida en el año 2000 por el cineasta portugués João Cé

Le paysage chez Robert Melançon. Entre milieu citadin et scène baroque

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Élise Lepage

2015-11-01

Full Text Available Cet article interroge le paysage urbain dans Le paradis des apparences (2004 de Robert Melançon en mobilisant tour à tour les concepts de « milieu » (Berque et d’« espaces mineur et majeur » (Desportes, qui invitent à une conception ouverte et dynamique du paysage. Soulignant tout d’abord l’intérêt du sujet melançonien pour les paysages « pauvres » de l’univers citadin, la réflexion se concentre ensuite sur l’importance de la médiation picturale et la valorisation toute baroque des apparences, des jeux d’illusions et autres trompe-l’œil dont fait son miel cette poésie par ailleurs pétrie d’une sobriété toute classique. This article questions the cityscape in Le paradis des apparences (2004 by Robert Melançon by discussing the concepts of « milieu » (Berque and « minor and major places » (Desportes that foster an open and dynamic conception of landscape. It first highlights the subject’s interest for “poor” and marginal cityscapes, before concentrating on the importance of the pictorial mediation and the baroque valorization of appearances, illusions, and other deceptive trompe-l’oeil, which are the very matter of this poetry that may not be as classical and understated as it first appears.

CTD and Water Sample Data from Research Vessel Robert Gordon Sproul in the NE Pacific, 24 October 2013 (NCEI Accession 0157082)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The expedition by research vessel Robert Gordon Sproul from 23 to 25 October 2013 had the objective to recover a broken mooring from the CORC project (Consortium on...

Lessons in power: Lyndon Johnson revealed. A conversation with historian Robert A. Caro.

Science.gov (United States)

Caro, Robert A

2006-04-01

No one can lead who does not first acquire power, and no leader can be great who does not know how to use that power. The trouble is that the combination of the two skills is rare. Amassing power requires ambition, a focused pragmatism, and a certain ruthlessness that is often at odds with the daring, idealistic vision needed to achieve great things with that power. The tension is as real in business as it is in politics. This magazine is replete with examples of successful senior managers who could not make the switch from ambitious executive to corporate leader because they did not know what to do with the power they had so expertly accumulated. Robert Caro is a student of power. For the past 27 years, the two-time Pulitzer prize-winning biographer of Robert Moses and Lyndon Johnson has focused on the question of how Johnson amassed and wielded power. Caro's deep understanding of the inner workings of power offers senior executives a nuanced picture of leadership at the highest level. In this wide-ranging conversation, Caro shares his insights about the nature of power, the complexity of ambition, and the role that the greater good can play in the making of a leader. Power doesn't always corrupt, he insists. But what it invariably does is reveal a leader's true nature. "Today, when CEOs have acquired more and more power to change our lives," Caro says,"they have become like presidents in their own right, and they, too, need to align themselves with something greater than themselves if they hope to become truly great leaders."

Rapid kit-based (68)Ga-labelling and PET imaging with THP-Tyr(3)-octreotate: a preliminary comparison with DOTA-Tyr(3)-octreotate.

Science.gov (United States)

Ma, Michelle T; Cullinane, Carleen; Waldeck, Kelly; Roselt, Peter; Hicks, Rodney J; Blower, Philip J

2015-12-01

Ge/(68)Ga generators provide an inexpensive source of a PET isotope to hospitals without cyclotron facilities. The development of new (68)Ga-based molecular imaging agents and subsequent clinical translation would be greatly facilitated by simplification of radiochemical syntheses. We report the properties of a tris(hydroxypyridinone) conjugate of the SSTR2-targeted peptide, Tyr(3)-octreotate (TATE), and compare the (68)Ga-labelling and biodistribution of [(68)Ga(THP-TATE)] with the clinical radiopharmaceutical [(68)Ga(DOTATATE)]. A tris(hydroxypyridinone) with a pendant isothiocyanate group was conjugated to the primary amine terminus of H2N-PEG2-Lys(iv-Dde)(5)-TATE, and the resulting conjugate was deprotected to provide THP-TATE. THP-TATE was radiolabelled with (68)Ga(3+) from a (68)Ge/(68)Ga generator. In vitro uptake was assessed in SSTR2-positive 427-7 cells and SSTR2-negative 427 (parental) cells. Biodistribution of [(68)Ga(THP-TATE)] was compared with that of [(68)Ga(DOTATATE)] in Balb/c nude mice bearing SSTR2-positive AR42J tumours. PET scans were obtained 1 h post-injection, after which animals were euthanised and tissues/organs harvested and counted. [(68)Ga(THP-TATE)] was radiolabelled and formulated rapidly in negative cells, and receptor binding and internalisation were specific. Animals administered [(68)Ga(THP-TATE)] demonstrated comparable SSTR2-positive tumour activity (11.5 ± 0.6 %ID g(-1)) compared to animals administered [(68)Ga(DOTATATE)] (14.4 ± 0.8 %ID g(-1)). Co-administration of unconjugated Tyr(3)-octreotate effectively blocked tumour accumulation of [(68)Ga(THP-TATE)] (2.7 ± 0.6 %ID g(-1)). Blood clearance of [(68)Ga(THP-TATE)] was rapid and excretion was predominantly renal, although compared to [(68)Ga(DOTATATE)], [(68)Ga(THP-TATE)] exhibited comparatively longer kidney retention. Radiochemical synthesis of [(68)Ga(THP-TATE)] is significantly faster, proceeds under milder conditions, and requires less manipulation

Aasta 2000 - meteoor, mis ohustab maailma : Nobeli majanduspreemia värske laureaat soovitab 1. detsembrist külmutada valuutakursid / Robert Mundell ; interv. Marshall Loeb

Index Scriptorium Estoniae

Mundell, Robert

1999-01-01

Nobeli majanduspreemia laureaadi Robert Mundelli intervjuu ajakirja Fortune endisele toimetajale Marshall Loebile teleprogrammis Marketwatch. Aasta 2000 probleem rahaturgudel. Jack Kempi kiri USA presidendile Bill Clintonile

Robert Wood Johnson Foundation Nurse Faculty Scholars program leadership training.

Science.gov (United States)

Campbell, Jacquelyn C; McBride, Angela Barron; Etcher, LuAnn; Deming, Katie

The Robert Wood Johnson Foundation Nurse Faculty Scholars program was created to address the nursing shortage via development of the next generation of national leaders in academic nursing. The leadership training combined development at the scholar's home institution with in-person didactic and interactive sessions with notable leaders in nursing and other disciplines. A curriculum matrix, organized by six domains, was evaluated quantitatively and qualitatively. What set this program apart is that it immersed junior faculty in concerted leadership development with regard to all aspects of the faculty role so that teaching interactively, making use of the latest in information technology, giving testimony before a policy-making group, participating in strategic planning, and figuring out how to reduce the budget without jeopardizing quality were all envisioned as part of the faculty role. The domains covered by this program could easily be used as the framework to plan other leadership-development programs for the next generation of academic leaders. Copyright © 2017 Elsevier Inc. All rights reserved.

Anthony (Tony) ROBERTS 5 March 1948 – 16 January 2008

CERN Multimedia

2008-01-01

Tony came from Netherton, a small town near Birmingham in the English West Midlands, where he grew up with his parents, who ran the local grocery store, "T.W. Roberts & Son". This is where he regularly liked to return, firstly to help his parents and later simply to spend time with them. Here undoubtedly lie the roots of his organizational skills and his ability to get on so well with others. He soon became interested in the rapidly-developing field of computing and this was how he first came to CERN, during the summer of 1973, at the age of 25. He joined the DD Division as an operator responsible for the "calculators" of that time, where he stayed until 1979 when he joined the Fellows and Associates Section of Personnel Division. He participated in the general computerisation of the Administration and continued his career in the Records Office of HR Department, a post he held until the end. Though still very British – ob...

The diffident naturalist Robert Boyle and the philosophy of experiment

CERN Document Server

Sargent, Rose-Mary

2009-01-01

In a provocative reassessment of one of the quintessential figures of early modern science, Rose-Mary Sargent explores Robert Boyle's philosophy of experiment, a central aspect of his life and work that became a model for mid- to late seventeenth-century natural philosophers and for many who followed them. Sargent examines the philosophical, legal, experimental, and religious traditions-among them English common law, alchemy, medicine, and Christianity-that played a part in shaping Boyle's experimental thought and practice. The roots of his philosophy in his early life and education, in his religious ideals, and in the work of his predecessors-particularly Bacon, Descartes, and Galileo-are fully explored, as are the possible influences of his social and intellectual circle. Drawing on the full range of Boyle's published works, as well as on his unpublished notebooks and manuscripts, Sargent shows how these diverse influences were transformed and incorporated into Boyle's views on and practice of experiment.

Obituary: Robert Mowbray Walker, 1929-2004

Science.gov (United States)

Schoenherr, Neil T.

2004-12-01

Robert M. Walker, PhD, Professor of Physics in Arts & Sciences and a faculty fellow of the McDonnell Center for the Space Sciences, died of stomach cancer Thursday, 12 February 2004, in Brussels, Belgium. He was 75. Walker worked on the frontiers of space research for more than four decades. Robert Walker was born in Philadelphia on 6 February 1929. His mother was Dorothy Potter and he considered Roger Potter his father though he was not his biological father. His early years were spent in New York City and in upstate New York. He attended the Bronx High School of Science, earned his BS in physics from Union College and in 1954, he received his PhD in particle physics from Yale University. He subsequently joined the General Electric Laboratory in Schenectady, New York where he studied the radiation effects in solids. His work on defects in irradiated copper is still regarded as the definitive work on the topic. In the early 1960s, Walker's discovery of fossil nuclear particle tracks in minerals was instrumental to new developments in geo-chronology and cosmic ray physics. In particular, his discovery of tracks from nuclei heavier than iron opened a new frontier of cosmic ray physics. He subsequently pioneered the use of plastics to detect and count such nuclei in cosmic ray balloon flights. Beginning in 1966, when he moved to Washington University and became the first McDonnell Professor of Physics, his research interests turned more toward space physics. He was the inaugural director of the McDonnell Center, which was established in 1975 by a gift from aerospace pioneer James S. McDonnell. Walker was a member of the NASA committee that allocated samples of the first returned lunar materials, and his laboratory led the way in deciphering their record of lunar, solar system and galactic evolution. Together with Ghislaine Crozaz and other colleagues, Walker made path breaking laboratory studies of the first moon rocks revealing the history of solar radiation and

Statistical ultrasonics: the influence of Robert F. Wagner

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Insana, Michael F.

2009-02-01

An important ongoing question for higher education is how to successfully mentor the next generation of scientists and engineers. It has been my privilege to have been mentored by one of the best, Dr Robert F. Wagner and his colleagues at the CDRH/FDA during the mid 1980s. Bob introduced many of us in medical ultrasonics to statistical imaging techniques. These ideas continue to broadly influence studies on adaptive aperture management (beamforming, speckle suppression, compounding), tissue characterization (texture features, Rayleigh/Rician statistics, scatterer size and number density estimators), and fundamental questions about how limitations of the human eye-brain system for extracting information from textured images can motivate image processing. He adapted the classical techniques of signal detection theory to coherent imaging systems that, for the first time in ultrasonics, related common engineering metrics for image quality to task-based clinical performance. This talk summarizes my wonderfully-exciting three years with Bob as I watched him explore topics in statistical image analysis that formed a rational basis for many of the signal processing techniques used in commercial systems today. It is a story of an exciting time in medical ultrasonics, and of how a sparkling personality guided and motivated the development of junior scientists who flocked around him in admiration and amazement.

Robert Alexy's Rules Ponderation and Narciso Baez's Theory Of Double Size of Human Rights in Analysis of Rights in Conflict Infanticide Concrete Case in Indigenous Villages

OpenAIRE

Rogério Gesta Leal; Fabio Biasi Pavão

2015-01-01

O presente artigo tem por objetivo analisar o tema da colisão de princípios e direitos fundamentais sob o prisma da teoria de Robert Alexy e de reflexões sobre a dupla dimensão dos direitos humanos de Narciso Leandro Xavier Baez. Para tanto, propõe uma análise dos conceitos elaborados por Robert Alexy sobre normas e princípios e situações de conflitos entre direitos. Alexy propõe regras de ponderação como alternativa à solução de conflitos entre princípios, proporcionando a prevalência de um ...

Robert Mandell: a pioneer and giant in the art and science of contact lenses.

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Polse, Kenneth A

2008-10-01

Robert B. Mandell is the quintessential modern clinical scientist. Over his long academic career, he has pioneered many advances in contact lens practice, ranging from a more complete understanding of corneal shape to the effects of contact lenses on corneal health. His classic text, Contact Lens Practice, first published in 1965, was reprinted 14 times in four editions up to 1988. Mandell's contributions to the advancement of the profession of optometry have always been characterized by a genuine concern for the patient and a steadfast belief that his research must have relevance to the practice of optometry.

Robert S(trange McNamara (junho de 1916 a julho de 2009: a ascensão imperfeita da tecnocracia

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Virgílio Caixeta Arraes

2009-08-01

Full Text Available o artigo trata da biografia de Robert McNamara,
falecido em julho de 2009. Ele foi Secretário de Defesa durante a gestão de John Kennedy e Lyndon
Johnson. Nesse sentido, ele foi um dos responsáveis
pelo fracasso da Guerra do Vietnã.

Spontaneous intracranial hemorrhage and multiple intracranial aneurysms in a patient with Roberts/SC phocomelia syndrome.

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Wang, Anthony C; Gemmete, Joseph J; Keegan, Catherine E; Witt, Cordelie E; Muraszko, Karin M; Than, Khoi D; Maher, Cormac O

2011-11-01

Roberts/SC phocomelia syndrome (RBS) is a rare but distinct genetic disorder with an autosomal recessive inheritance pattern. It has been associated with microcephaly, craniofacial malformation, cavernous hemangioma, encephalocele, and hydrocephalus. There are no previously reported cases of RBS with intracranial aneurysms. The authors report on a patient with a history of RBS who presented with a spontaneous posterior fossa hemorrhage. Multiple small intracranial aneurysms were noted on a preoperative CT angiogram. The patient underwent emergency craniotomy for evacuation of the hemorrhage. A postoperative angiogram confirmed the presence of multiple, distal small intracranial aneurysms.

LOS DERECHOS FUNDAMENTALES COMO NORMAS JURÍDICAS MATERIALES EN LA TEORÍA DE ROBERT ALEXY

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María Dolores Pérez Jaraba

2011-12-01

ABSTRACT. The theory of the civil rights of Robert Alexy is based on a material concept of rule of law. It is two-fold. On the one hand, is defined by the traits of the principles, consistent with the idea of ??correct argument. But on the other hand, weight is still the legal validity of the rules contained civil rights, constitutional rules considered. As argued in the work, this ambiguity of the norm theory allows for different approaches Alexy, positivist and positivist, which is a sign of its theoretical richness

An experimental ‘Life’ for an experimental life : Richard Waller's biography of Robert Hooke (1705)

OpenAIRE

Moxham, Noah

2016-01-01

Richard Waller's ‘Life of Dr Robert Hooke’, prefixed to his edition of Hooke's Posthumous Works (1705), is an important source for the life of one of the most eminent members of the early Royal Society. It also has the distinction of being one of the earliest biographies of a man of science to be published in English. I argue that it is in fact the first biography to embrace the subject's natural-philosophical work as the centre of his life, and I investigate Waller's reasons for adopting thi...

Validation of the Penn Inventory of Scrupulosity (PIOS) in scrupulous and nonscrupulous patients: Revision of factor structure and psychometrics.

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Huppert, Jonathan D; Fradkin, Isaac

2016-06-01

Scrupulosity, or obsessive-compulsive symptoms related to religiosity or religion, is a common presentation of obsessive compulsive disorder (OCD), and it is important to elucidate its phenomenology and measurement. Today, the most widespread questionnaire for the assessment of scrupulosity is the Penn Inventory of Scrupulosity (PIOS). The current study examines the psychometric properties of the PIOS in outpatient, treatment-seeking patients. Results of a confirmatory factor analysis suggested an unsatisfactory fit for previously suggested factor structures. A follow-up exploratory factor analysis suggested that a bifactor model was the most suitable solution. In addition, the scores of the PIOS and its revised subscales were found to have moderate-good concurrent validity; however, its scores discriminated poorly between patients with scrupulous obsessions and patients with OCD and other repugnant obsessions. Group differences and receiver operating characteristics (ROC) analyses both indicated that the PIOS is more suitable in discriminating scrupulous obsessions in Christian patients but not in other religious groups (i.e., Jews, nonreligious patients). Additional analyses revealed that the co-occurrence of scrupulous and other repugnant obsessions is also moderated by religious affiliation. These results raise questions in terms of grouping scrupulosity with other repugnant obsessions and suggest for the need of culturally sensitive instruments of scrupulosity. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Multistep translation and cultural adaptation of the Penn acoustic neuroma quality-of-life scale for German-speaking patients.

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Kristin, Julia; Glaas, Marcel Fabian; Stenin, Igor; Albrecht, Angelika; Klenzner, Thomas; Schipper, Jörg; Eysel-Gosepath, Katrin

2017-11-01

Monitoring the health-related quality of life (HRQOL) for patients with vestibular schwannoma (VS) has garnered increasing interest. In German-speaking countries, there is no disease-specific questionnaire available similar to the "Penn Acoustic Neuroma Quality-of-life Scale" (PANQOL). We translated the PANQOL for German-speaking patients based on a multistep protocol that included not only a forward-backward translation but also linguistic and sociocultural adaptations. The process consists of translation, synthesis, back translation, review by an expert committee, administration of the prefinal version to our patients, submission and appraisal of all written documents by our research team. The required multidisciplinary team for translation comprised head and neck surgeons, language professionals (German and English), a professional translator, and bilingual participants. A total of 123 patients with VS underwent microsurgical procedures via different approaches at our clinic between January 2007 and January 2017. Among these, 72 patients who underwent the translabyrinthine approach participated in the testing of the German-translated PANQOL. The first German version of the PANQOL questionnaire was created by a multistep translation process. The responses indicate that the questionnaire is simple to administer and applicable to our patients. The use of a multistep process to translate quality-of-life questionnaires is complex and time-consuming. However, this process was performed properly and resulted in a version of the PANQOL for assessing the quality of life of German-speaking patients with VS.

Feminism and Faith: Exploring Christian Spaces in the Writing of Sara Maitland and Michèle Roberts

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Arina LUNGU-CIRSTEA

2011-03-01

Full Text Available En 1983, les féministes britanniques Sara Maitland et Jo Garcia ont publié Walking on the Water (London : Virago, une collection d’essais, de récits, de poèmes et de photos produits par des femmes sur le thème de la spiritualité. Les contributrices ont été en particulier invitées à explorer la relation entre leur identité féministe et leurs croyances religieuses. Le ton de ces contributions varie fortement, allant de l’envie passionnée de concilier les objectifs du féminisme avec le christianisme à un rejet total de l’Eglise comme institution patriarcale suprême. Cet article met en dialogue des récits diamétralement opposés du rapport entre christianisme et féminisme en s’intéressante plus particulièrement à deux des contributrices, Sara Maitland (1950 - et Michèle Roberts (1949 - . Ces deux écrivaines, qui se sont activement impliquées dans les mouvements féministes des années 1970, ont toutes deux lutté pour se réconcilier avec leur héritage chrétien. Néanmoins, alors que Maitland tente essentiellement de revisiter le christianisme en y incorporant les points essentiels d’une idéologie féministe, Roberts sent le besoin impérieux de se défaire de son identité religieuse afin de devenir indépendante ; en effet, dans son autobiographie Paper Houses (2007 elle décrit son éducation catholique comme “autoritaire et misogyne” (16. Cet article explore les façons dont l’identité spirituelle se construit dans le jeu complexe des interactions entre féminisme et foi. Il se propose, dans une perspective comparatiste, d’analyser d’une part le recueil de nouvelles de Sara Maitland intitulé A Book of Spells, et d’autre part, le roman acclamé de Michèle Roberts, Daughters of the House. Dans ces écrits, Maitland et Roberts ont un objectif commun qui est de renégocier la place des femmes dans l’histoire chrétienne dont elles reconnaissent – il est vrai à partir de perspectives diff

Number theory and modular forms papers in memory of Robert A Rankin

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Ono, Ken

2003-01-01

Robert A. Rankin, one of the world's foremost authorities on modular forms and a founding editor of The Ramanujan Journal, died on January 27, 2001, at the age of 85. Rankin had broad interests and contributed fundamental papers in a wide variety of areas within number theory, geometry, analysis, and algebra. To commemorate Rankin's life and work, the editors have collected together 25 papers by several eminent mathematicians reflecting Rankin's extensive range of interests within number theory. Many of these papers reflect Rankin's primary focus in modular forms. It is the editors' fervent hope that mathematicians will be stimulated by these papers and gain a greater appreciation for Rankin's contributions to mathematics. This volume would be an inspiration to students and researchers in the areas of number theory and modular forms.

Essay in honor of Robert Motherwell's centenary: “temporalized form”: mediating Romanticism and American Expressionism—Robert Motherwell, Henri Bergson, and the ontological origins of abstraction around 18001

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Manfred Milz

2016-02-01

Full Text Available The influence of process metaphysics on the development of abstraction between 1800 and the second half of the 20th century can best be exemplified with the case of the American Expressionist painter and theoretician Robert Motherwell (1915–1991. Taking as its starting point Motherwell's exposure to the History of Idea of Romanticism, Arthur O. Lovejoy's yearlong seminar at Harvard (1937–38, the artist's affinity with fluid forms through motion brushstrokes in Romanticist painting is analyzed as a preformative stage of his own transitory creations. This is done by structural comparison between Motherwell's written reflections and Romanticist art theory. Motherwell's specific perception through Bergson's and Whitehead's lens of immanence and multiplicity, I argue, resonates Lovejoy's principle of “Romantic Evolutionism,” in its turn from being to becoming, derived from the philosophies of the Spiritualist Maine de Biran and the Idealist–Empiricist George Berkeley.

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

OpenAIRE

Anibal Meza; Carmen Lazarte

1993-01-01

Se reseñan aspectos fundamentales de la psicología del aprendizaje de Robert Gagné, destacando sus bases filosóficas (positivismo y pragmatismo) y científicas ( conductismo y modelo de procesamiento de la información) y luego se evalúan dichos aspectos desde una perspectiva epistemológica en términos de sus <

Wearing the crown of Solomon? Chief Justice Roberts and the Affordable Care Act "tax".

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Muise, Robert J; Yerushalmi, David

2013-04-01

Attempting to play the role of King Solomon in his PPACA decision, Chief Justice John Roberts split the baby perversely by ruling it was not a tax under the Anti-Injunction Act, which would have likely deprived the Court of jurisdiction to hear this pre-enforcement challenge to the individual mandate, but it was a tax for taxing and spending purposes even though Congress said it was a "penalty" and not a tax. And the Chief Justice had to twist further his "wisdom" to hold that it was not an unconstitutional direct tax, even though that is exactly what it is, if it is a tax in the first instance.

The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world.

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Gest, Howard

2005-01-01

Robert Hooke played important roles in the early development of the Royal Society of London. As Curator of Experiments of the Society, he became a pioneering microscopist, prolific inventor, astronomer, geologist, architect, and an effective surveyor of the City of London following the Great Fire of 1666. Hooke's Micrographia (1665) revealed the microscopic structures of numerous biological and inorganic objects and became an important source of information for later studies. Aside from the body of detailed observations reported and depicted in Micrographia, the Preface is in itself an extraordinary document that exhibits Hooke's fertile mind, philosophical insights, and rare ability to look into the future.

Robert Boyle, Transmutation, and the History of Chemistry before Lavoisier: A Response to Kuhn.

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Newman, William R

2014-01-01

In an influential article of 1952, Thomas Kuhn argued that Robert Boyle had little or no influence on the subsequent development of chemistry. This essay challenges Kuhn's view on two fronts. First, it shows that Johann Joachim Becher developed his hierarchical matter theory under the influence of Boyle and then transmitted it to the founder of the phlogiston theory, G. E. Stahl. Second, this essay argues that transmutational matter theories were not necessarily opposed to the existence of stable chemical species, pace Kuhn. Boyle's corpuscular theory descended largely from the tradition of "chymical atomism," which often advocated both chrysopoeia and the reality of robust chemical substances.

Robert Boyle and the representation of imperceptible entities.

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Wragge-Morley, Alexander

2018-03-01

In this essay, I examine Robert Boyle's strategies for making imperceptible entities accessible to the senses. It is well known that, in his natural philosophy, Boyle confronted the challenge of making imperceptible particles of matter into objects of sensory experience. It has never been noted, however, that Boyle confronted a strikingly similar challenge in his natural theology - he needed to make an equally imperceptible God accessible to the senses. Taking this symmetrical difficulty as my starting point, I propose a new approach to thinking about the interconnections between Boyle's natural philosophy and natural theology. For the most part, studies of science and religion in the early modern period work by seeking out the influence of explicitly stated religious beliefs on scientific ideas. I argue, by contrast, that we need to focus on Boyle's representational practices, using his attempts to represent imperceptible entities as a means of uncovering metaphysical and theological presuppositions that he did not always articulate when stating his religious beliefs. With new interpretations of both A Discourse of Things Above Reason (1681) and Some Physico-Theological Considerations about the Possibility of the Resurrection (1675), I show that there were crucial similarities between Boyle's practices for representing both God and atoms. I go on to show, moreover, that Boyle used these practices to enact an ontological stance at odds with one of his most important professed beliefs.

Cinema and the Great War - Andrew Kelly, 1997. History by Hollywood. The use and abuse of the American past - Robert Brant Toplin, 1996

NARCIS (Netherlands)

Kester, Bernadette

1998-01-01

textabstractReview of: Cinema and the Great War. Andrew Kelly, Londen, New York (Routledge), 1997, 219 p.History by Hollywood. The use and abuse of the American past. Robert Brant Toplin, Chicago (Urbana), 1996, 267 p.

Overview of the Robert Wood Johnson Foundation Nurse Faculty Scholars program.

Science.gov (United States)

Campbell, Jacquelyn; Ladden, Maryjoan D; McBride, Angela Barron; Cimino, Andrea; Kostas-Polston, Elizabeth; Deming, Katie

The Robert Wood Johnson Foundation Nurse Faculty Scholars program was created to address the nursing faculty shortage and thereby decrease the nursing shortage. The purpose of the study was to describe the program development, implementation, and ongoing outcome evaluation. Data on scholarly productivity, impact of research, research funding, and leadership positions were compiled, including an h-index (impact of publications) comparison with a comparison group of other interdisciplinary faculty at the same institutions of the 90 current and alumni scholars. There is evidence of the achievements of the individual scholars; however, the effect of the synergy of the multiple components of the program is difficult to capture in traditional evaluation strategies. The sense of possibility and responsibility (to the profession, to improving the health of all Americans, and to one's school of nursing and university) was a significant outcome of the program. Lessons learned from the program are important for the leadership development and retention of nursing faculty. Copyright © 2017 Elsevier Inc. All rights reserved.

75 FR 57846 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Science.gov (United States)

2010-09-23

... Aircraft Certification Office (ACO), 1701 Columbia Avenue, College Park, Georgia 30337; telephone: (404... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1... the Docket Office (phone: 800-647-5527) is Document Management Facility, U.S. Department of...

78 FR 40958 - Amendment of Restricted Areas R-2504A & R-2504B; Camp Roberts, CA, and Restricted Area R-2530...

Science.gov (United States)

2013-07-09

...-0515; Airspace Docket No. 13-AWP-8] RIN 2120-AA66 Amendment of Restricted Areas R-2504A & R-2504B; Camp Roberts, CA, and Restricted Area R-2530; Sierra Army Depot, CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends the descriptions of restricted areas R...

Pena de muerte, peso de la ley, justicia simbólica y cultura jurídica escocesa en “El Weir de Hermiston” de Robert Louis Stevenson (Death Penalty, Force of the Law, Symbolic Justice and Scottish Legal Culture in Robert L. Stevenson's ‘Weir of Hermiston'

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Iker Nabaskues

2017-12-01

Full Text Available La novela El Weir de Hermiston del autor escocés Robert Louis Stevenson es una valiosa fuente para el análisis del campo del Derecho y Literatura (Law and Literature. En la obra del autor escocés se retratan personajes basados en importantes juristas de la historia de Escocia y se plasma una cultura jurídica con fuertes influencias de la Escuela de la Ilustración Escocesa, proyectando sobre la novela un sentido de la justicia particular, ambiguo y sutil característicos tanto de Escocia como del genial escritor y moralista.Robert Louis Stevenson´s novel Weir of Hermiston is an interesting source for the analysis from the Law and Literature approach. Stevenson shows characters based on important jurists in the Scottish history and a legal culture rooted in the Scottish enlightenment tradition, projecting on the novel a particular, ambiguous and subtle sense of justice, characteristic of Scotland and the great writer and moralist.DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=3067289

Understanding Robert Lucas (1967-1981: his influence and influences

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Alexandre F.S. Andrada

2017-05-01

Full Text Available This paper analyzes Robert Lucas's contribution to economic theory between 1967 (year of his first solo publication and 1981 (the year before the emergence of Real Business Cycle approach, and it has two parts. The first one, using citation data from three different sources, we try to answer two questions: (i What are Lucas's most influential papers currently? (ii How has this influence changed through time? We show, for instance, that according to two of those three sources, Lucas's most influential paper today is not from his business cycle research agenda, which gave him his Nobel Prize in 1995. Moreover, it is clear the loss of influence of Lucas's macroeconomic theory since the early 1980s. In the second part, by cataloging all the works that Lucas had used as bibliographical references in his papers and separating them in two categories (positive and negative, we try to understand who exerted influence on him. We show that the author that Lucas most cited in a positive context were John Muth, Milton Friedman and Edmund Phelps. The authors more often cited in a negative context were John M. Keynes and A. W. Phillips. We discuss the reasons behind this data.

Caruso St John y Robert Smithson: Interferencias

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Emilia Hernández Pezzi

2016-05-01

Full Text Available Resumen Los discursos cruzados son el soporte común del presente número de Cuadernos. El cruce que planteamos tiene como protagonistas al artista Robert Smithson y a los arquitectos Adam Caruso y Peter St John. Estos últimos hacen mención del trabajo del artista norteamericano para explicar su proyecto de remodelación de Stortorget, la plaza de la catedral en el centro de Kalmar, Suecia. A partir de aquí, comenzamos una exploración del trabajo y las preocupaciones de ambos que nos permite dibujar convergencias y sintonías procesuales por encima de las diferencias temáticas, ideológicas y estilísticas. Al disponer en paralelo la obra de Smithson y Caruso St John descubrimos vibraciones y resonancias que muestran una interacción productiva de sus preocupaciones. La materia se convierte en sus propuestas en un objeto activo y sensible, un depósito energético con el que operar. El traslado de piedras en Stortorget convoca la memoria de la ciudad del mismo modo que el basalto y la sal del Spiral Jetty, erosionados por el tiempo, nos hablan de procesos abiertos. El tiempo y la memoria pasan a ser soportes estratégicos con los que construyen sus miradas. Los objetos se disuelven en las relaciones que establecen con su entorno produciendo equilibrios frágiles e instantáneos. De esta manera el artículo pretende generar un vórtice de reflexión, una espiral en cuyo recorrido se manifiesten las tensiones parciales del cruce propuesto, sus fijezas momentáneas.

Chromatid repulsion associated with Roberts/SC phocomelia syndrome is reduced in malignant cells and not expressed in interspecies somatic-cell hybrids.

Science.gov (United States)

Krassikoff, N E; Cowan, J M; Parry, D M; Francke, U

1986-01-01

Different cell types from a female patient with Roberts/SC phocomelia syndrome were evaluated quantitatively for the presence of repulsion of heterochromatin and satellite regions of mitotic chromosomes. Whereas EBV-transformed lymphoblasts from an established cell line revealed these phenomena at frequencies equal to those in PHA-stimulated lymphocytes and cultured skin fibroblasts, aneuploid cells from a metastatic melanoma displayed them at 50% lower frequency. Cocultivation of the patient's fibroblasts with either an immortal Chinese hamster cell line or with a human male fibroblast strain carrying a t(4;6)(p14;q21) translocation showed that the phenomenon was not corrected or induced by a diffusible factor or by cell-to-cell contact. In each experiment, only the patient's metaphase spreads revealed chromatid repulsion. In fusion hybrids between the patient's fibroblasts and an established Chinese hamster cell line, the human chromosomes behaved perfectly normally, suggesting that the gene product which is missing or mutant in Roberts/SC phocomelia syndrome is supplied by the Chinese hamster genome. Images Fig. 1 Fig. 2 Fig. 3 PMID:3788975

Health aspects of Arctic exploration – Alaska's medical history based on the research files of Dr. Robert Fortuine

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Kathleen Murray

2013-08-01

Full Text Available Background . Robert Fortuine provided basic medical care to Alaska Native people, chronicled the Health Aspects of Arctic Exploration and through a number of influential publications, was the first to thoroughly document and analyse Alaska's Medical History. This overview of his published work will provide the reader with a detailed overview, so that they can begin to explore Dr. Fortuine's many published works in more detail. Objective . This review will explore Alaska's Medical History and the Health Aspects of Arctic Exploration through the research files and the 10 most significant publications of Dr. Robert Fortuine. Design . Review of Dr. Fortuine's major works and the master bibliography has over 3,000 references and 81 subjects. The master bibliography is a merger of 55 separate bibliographies, which provides a wealth of bibliographic information. This paper will describe his 10 most significant publications, 2 of which began as a journal issue. Results . Dr. Fortuine was a prolific writer throughout his career, publishing 134 articles and books. He wrote papers and books on Alaska's medical history, tuberculosis and health care delivery from Russian–America through the Public Health Service efforts in the territory and then the State of Alaska. The master bibliography has over 3,000 references and 81 subjects. This list has a significant number of entries for tuberculosis with almost one-third of the entries including this heading. Others dwell on the history of “pre-contact” health, the history of Alaska Native health care, the history of the Alaska Department of Health, especially the tuberculosis programme, the role of the US Public Health Service and traditional medicine. He completely reviewed every Governors’ and the US Surgeon General's reports in regard to Alaska content. This paper describes his 10 most significant publications. Conclusions . Robert Fortuine's published works offer a wealth of information and insight

Robert Lowell’s Culturally Coded Lexis

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Lidija Davidovska

2014-12-01

Full Text Available In this paper, I will examine how a vital ele­ment of Robert Lowell’s descriptive and narrative struc­tures, i.e., the lexis, promise to unfold the “layers” of the culture that served as context for Life Studies. This in­volves exploring both the denotations and connotations of his culturally encoded lexis, that is, the external mean­ings of certain words and phrases before they “en­ter” the poem and the internal meanings they acquire after entering the poem. This process of “verbal osmo­sis”, when words absorb meaning from these different contexts, is, what I believe, critic and linguist Winifred Nowottny describes as “give and take between those patterns” (Fowler, 2009: 31. My analysis will focus on the sociolinguistic patina accrued on certain units of Lowell’s poetic lexis, such as names of historical people, events and concepts belonging to American and Euro­pean spiritual cultures and traditions, as well as brand names from popular material culture of the first half of the twentieth century. The analysis will also dwell on the use of idioms, catch phrases and other verbal clichés which reflect the culture that generated them. They func­tion as verbal “ready-mades” that additionally rein­force Lowell’s well-known anecdotal, colloquial and infor­mal poetic language. The choice of these particular lexical items is significant as they reflect the categoriza­tion of the world and the experience of the poetic voice or the “language user” in broader linguistic terms. At the same time, the categorization of the experience reflects the ideational position, the worldview of the language user. In the context of his poetics of immanence and experi­ence, this culturally coded poetic diction is ana­lyzed as another authentic and documented presenta­tion of immanent narrator’s “lived experience”.

Robert J. Shiller: Nobel prize for 2013: Capital market efficiency

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Pantelić Svetlana

2015-01-01

Full Text Available In 2013 the Nobel Prize in Economic Sciences was awarded to the American economists, Eugene Fama, Lars Peter Hansen and Robert Shiller. The monetarists, Fama and Hansen, from the University of Chicago, and the Neo- Keynesian, Shiller, from the Yale University, according to the Swedish Royal Academy, won this prestigious prize for their research providing mathematical and economic models to determine (irregularities in the stock value trends at the stock exchanges. With his colleagues, in the 1960s Fama established that, in the short term, it is extremely difficult to forecast stock prices, given that new information gets embedded in the prices rather quickly. Shiller, however, determined that, although it is almost impossible to predict the stock prices for a period of few days, this is not true for a period of several years. He discovered that the stock prices fluctuate much more substantially than corporation dividents, and that the relationship between prices and dividends tends to decline when high, and to grow when low. This pattern does not apply only to stocks, but also to bonds and other forms of capital.

OF SOCIAL NETWORKS AND LINGUISTIC INFLUENCE: THE LANGUAGE OF ROBERT LOWTH AND HIS CORRESPONDENTS

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Ingrid Tieken-Boon van Ostade

2005-06-01

Full Text Available Analysing the unpublished correspondence of Robert Lowth, author of A Short Introduction to English Grammar (1762, this article attempts to find evidence of linguistic influence between people belonging to the same social network. Such evidence is used to try and determine where Lowth found the linguistic norm he presented in his grammar. Adding to the data presented by Nevalainen and Raumolin Bmnberg (2003 on the basis of their study of fourteen morphosyntactic items in the Corpus of Early English Correspondence, a detailed analysis is presented of eighteenth-century English. One of the results is an explanation for the presence in Lowth's grammar of the stricture against double negation at a time when double negation was no longer in current use.

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

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Anibal Meza

1993-12-01

Full Text Available Se reseñan aspectos fundamentales de la psicología del aprendizaje de Robert Gagné, destacando sus bases filosóficas (positivismo y pragmatismo y científicas ( conductismo y modelo de procesamiento de la información y luego se evalúan dichos aspectos desde una perspectiva epistemológica en términos de sus <

Human radiation studies: Remembering the early years. Oral history of biophysicist Robert Edmund Rowland, Ph.D., January 27, 1995

International Nuclear Information System (INIS)

1995-06-01

This report provides a transcript of an oral interview with Dr. Robert Edmund Rowland by representatives of the US DOE Office of Human Radiation Research on January 27, 1995. Dr. Rowland was involved with the study of radium in the human body since 1950 and relates his knowledge of over 40 years of study of radium in the human body including dial painters, inmates of Elgin State Hospital, and other treated therapeutically with radium

spareparts.exchange: Rahim and Robert, Stitched Together in Silence (Creative Intervention

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Monir Moniruzzaman

2016-12-01

Full Text Available Spare Parts (spareparts.exchange is an art installation created collaboratively by Heather Dewey-Hagborg, Jim Ruxton, Camille Turner, and Monir Moniruzzaman. Based on Monir Moniruzzaman’s ethnographic research on the illicit organ trade, Spare Parts explores the ethics of organ trafficking and the emergence of bodily inequality in times of transplant tinkering. In this installation, the viewer is confronted with life sized video projections of Rahim Sheikh, a Bangladeshi kidney seller and Robert Zurrer, a Canadian kidney transplant recipient/buyer, whose kidneys were commodified in the marketplace. The video projections are installed so that the individuals sit in silence facing each other.  Spare Parts highlights the intimacy of spare parts, the economy of the global marketplace, the perils of techno-medicine, and what is means to be human in the 21st century. The installation captures that the buying and selling of body parts is not just a market transaction, but rather represents the desperation, dis/connection, and inequality that exists in the trade.

The art of compromise: the founding of the National Gallery of British Art, 1890-1892

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Amy Woodson-Boulton

2015-03-01

Full Text Available This article argues that the press played a key role in defining the Tate Gallery by facilitating a national debate about the siting, nature, and purpose of the proposed National Gallery of British Art. Art critics, politicians, journalists and a variety of newspaper editors weighed in on whether Britain should create a museum of modern art, a museum of national art, or both. The understanding of British art as quintessentially modern at the time of the founding of the Gallery meant that from the beginning the Tate Gallery was founded as both the National Gallery of British Art and a museum of modern art. The changing definition of modern art in the twentieth century, however, created fractures between these two identities that eventually led to the split between Tate Britain and Tate Modern.

Something black in the American Psyche: formal innovation and Freudian imagery in the comics of Winsor McCay and Robert Crumb.

Science.gov (United States)

Shannon, Edward A

2010-01-01

Winsor McCay’s Little Nemo in Slumberland anticipates Robert Crumb’s work. McCay’s innocent dreamscapes seem antithetical to the sexually explicit work of anti-capitalist Crumb, but Nemo looks forward to Crumb in subject and form. Nemo’s presentation of class, gender, and race, and its pre-Freudian sensibility are ironic counterpoints to Crumb’s political, Freudian comix.

Statement of Robert Bernero, Deputy Director, Office of Nuclear Material Safety and Safeguards, Nuclear Regulatory Commission: Accompanied by Robert Browning, Director, Division of High-Level Waste Management

International Nuclear Information System (INIS)

Anon.

1987-01-01

Mr. Chairman, members of the Committee, thank you for this opportunity to present the views of the Nuclear Regulatory Commission (NRC) on the Department of Energy's (DOE) program for disposal of civilian high-level wastes. I have with me Mr. Robert Browning, Director of NRC's Division of High-Level Waste Management. As you know, we are in the pre-licensing consultation phase of the repository program. DOE has the responsibility to conduct site characterization activities to acquire data necessary to evaluate the suitability of each candidate site for an application to the Commission for construction authorization. I would like to discuss some of our concerns about site characterization at the three sites recommended to an approved by the President for characterization as candidate sites. It will then discuss our comments on DOE's Draft Mission Plan Amendment dated January, 1987 and, more generally, our interaction with DOE. Finally, I would like to describe our quality assurance activities. I will be happy to respond to any questions from the Committee

Preparation of Ta Te2 thin films by laser ablation

International Nuclear Information System (INIS)

Zidan, M.D.; Alkhwam, M.; Alkhasm, M.

2006-03-01

The laser ablation system consisting of a vacuum chamber and Nd-YAG laser has been built for deposition TaTe 2 on three different substrates (Silicon, glass, and Aluminium). The surface topography of the prepared thin films has been studied by atomic force microscopy (AFM). TaTe 2 powder was characterized by using x-ray diffraction. The crystallinity of the thin films was examined by x-ray diffraction (XRD). The results show no peaks corresponding TaTe 2 , but there are some indications to the Ta 3 N 5 . (author)

The Robert Wood Johnson Foundation Nurse Faculty Scholars Program: An opportunity for junior nurse faculty

Science.gov (United States)

Coffman, Maren J.; Goodman, Janice H.; Thomas, Tami L.; Roberson, Donna

2014-01-01

The Robert Wood Johnson Foundation Nurse Faculty Scholars program provides promising junior faculty extramural funding, expert mentoring, and the training needed to be successful in the academic role. The Nurse Faculty Scholars program, which admitted its first cohort in 2008, is designed to address the nursing faculty shortage by enhancing leadership, educational, and research skills in junior nursing faculty. This article provides an overview of the program, its purpose, and its eligibility requirements. The authors give strategies for selecting mentors, developing the written application, and preparing for an oral interview. Finally, the authors provide an analysis of funded institutions, research design and methods from current and recently funded projects, and rank and positions held by nursing mentors. PMID:22818282

Direitos fundamentais, ponderação e racionalidade jurídica nas decisões judiciais brasileiras: uma leitura a partir de Robert Alexy / Fundamental rights, balancing and legal rationality in brazilian judicial decisions: a reading from Robert Alexy

OpenAIRE

Heletícia Leão de Oliveira

2016-01-01

Este artigo analisa aspectos relevantes da dogmática dos direitos fundamentais e do seu sopesamento a partir do pensamento de Robert Alexy, cuja teoria tenta responder de forma racional e fundamentada as questões axiológicas. Alega-se que a ponderação utilizada pelos tribunais brasileiros foi transformada em um princípio e está longe da fórmula alexyana original, pois ela leva à discricionariedade. Para que as decisões judiciais não sejam acusadas de serem arbitrárias e ilegítimas, é necessár...

Bookshelf (Conceptual Foundations of Modern Particle Physics, by Robert E. Marshak)

International Nuclear Information System (INIS)

Fritzsch, Harald

1994-01-01

Particle physics really began as an independent scientific discipline after the Second World War. Robert Marshak was one of its pioneers on the theoretical front, starting out his career with important contributions on meson theory (together with Hans Bethe). The life of Marshak, who died in December 1992, was intimately interwoven with the post-war development of particle physics. His work on weak interaction theory was an important step towards the formulation of the V-A theory, the main pillar on which the modern electroweak theory rests erected. He is also remembered as the founder of the biennial 'Rochester' conference series (March 1993, page 24). Just before his death Robert Marshak finished writing his book on the concepts of particle physics. The book starts out with an historical account of the development of the field. He divides it into the startup period (1945-60) - the period of meson physics, the physics of strange particles, parity violation etc; the heroic period (1960-1975) when the Standard Model of the electroweak and strong interactions was developed; and finally the period of consolidation and speculation (since 1975). Marshak's recollection of the development of particle physics represents a personal view, worth reading by young researchers, although it does not attempt to provide a complete picture. After the historical chapter Marshak introduces the reader to the basics of quantum field theory (space-time symmetries, global internal symmetries and their breaking, gauge symmetries). Later he turns to a description of QCD and the gauge theory of the electroweak interactions. A whole chapter is devoted to the problems related to anomalies. In the last part of the book Marshak discusses various hypotheses of unifying the strong and electroweak interactions, especially the various facets of the SO(10) theory, followed by a long discussion of the fermion generation problem and of preon models. The book concludes with an extensive

Implementation of Robert's Coping with Labor Algorithm© in a large tertiary care facility.

Science.gov (United States)

Fairchild, Esther; Roberts, Leissa; Zelman, Karen; Michelli, Shelley; Hastings-Tolsma, Marie

2017-07-01

to implement use of Roberts' Coping with Labor Algorithm © (CWLA) with laboring women in a large tertiary care facility. this was a quality improvement project to implement an alternate approach to pain assessment during labor. It included system assessment for change readiness, implementation of the algorithm across a 6-week period, evaluation of usefulness by nursing staff, and determination of sustained change at one month. Stakeholder Theory (Friedman and Miles, 2002) and Deming's (1982) Plan-Do-Check-Act Cycle, as adapted by Roberts et al (2010), provided the framework for project implementation. the project was undertaken on a labor and delivery (L&D) unit of a large tertiary care facility in a southwestern state in the USA. The unit had 19 suites with close to 6000 laboring patients each year. full, part-time, and per diem Registered Nurse (RN) staff (N=80), including a subset (n=18) who served as the pilot group and champions for implementing the change. a majority of RNs held a positive attitude toward use of the CWLA to assess laboring women's coping with the pain of labor as compared to a Numeric Rating Scale (NRS). RNs reported usefulness in using the CWLA with patients from a wide variety of ethnicities. A pre-existing well-developed team which advocated for evidence-based practice on the unit proved to be a significant strength which promoted rapid change in practice. this work provides important knowledge supporting use of the CWLA in a large tertiary care facility and an approach for effectively implementing that change. Strengths identified in this project contributed to rapid implementation and could be emulated in other facilities. Participant reports support usefulness of the CWLA with patients of varied ethnicity. Assessment of change sustainability at 1 and 6 months demonstrated widespread use of the algorithm though long-term determination is yet needed. Copyright © 2017 Elsevier Ltd. All rights reserved.

Book Review by Daniel Moran of The Iraq War: Strategy, Tactics, and Military Lessons, by Anthony H. Cordesman, and The Iraq War: A Military History, by Williamson Murray and Major General Robert H. Scales

OpenAIRE

Moran, Daniel

2004-01-01

Reviewed: TThe Iraq War: Strategy, Tactics, and Military Lessons, by Anthony H. Cordesman, and The Iraq War: A Military History, by Williamson Murray and Major General Robert H. Scales The United States and its allies went to war against Iraq in 2003, as Williamson Murray and Robert Scales reasonably propose, “to make an example out of Saddam’s regime, for better or worse” (p. 44). Exactly what the war exemplified, and whether the results are better or worse than might have be...

Elsa Baxter, head of the Swiss Post Office's Stamps and Philately Unit, presents to Robert Aymar, CERN's Director-General, the Swiss commemorative stamp dedicated to CERN

CERN Multimedia

Patrice Loiez

2004-01-01

'I am delighted to offer you a special stamp which commemorates your Laboratory's fifty-year history and pays tribute to its achievements, its pioneering spirit and its perseverance' said Mrs Baxter to Robert Aymar, CERN's Director-General.

Friedrich Robert Helmert, founder of modern geodesy, on the occasion of the centenary of his death

Science.gov (United States)

Ihde, Johannes; Reinhold, Andreas

2017-08-01

Friedrich Robert Helmert died in Potsdam in 1917 at the age of 74 after serving for over 30 years as director of the Royal Prussian Geodetic Institute and of the Central Bureau of the Internationale Erdmessung, the forerunner of today's International Association of Geodesy. He dedicated his life and his scientific career to the field of geodesy. His teachings on theoretical and physical geodesy were incorporated into university curricula around the world and hence into international endeavours to measure planet Earth. The purpose of this article is to illustrate the impact he has had on the development of modern geodesy and on the related sciences.

A CONVERSATİON ON INSTRUCTİONAL DESİGN WİTH ROBERT GAGNÉ AND DAVİD MERRİLL NO:1

OpenAIRE

Necmi Esgi; Omer Arslan

2016-01-01

The purpose of the study is to bring in the first part of diachronic conversation on instructional design with Robert Gagné and David Merrill to transcripts. This conversation was hosted by Utah State University, in the United States of America, in July 10, 1989. Throughout the history of instructional design, these two scientists are considered as the pioneers of the field and in these sessions, they summarize and compare their studies. In the first session, Gagné and Merrill represent their...

Dr Robert Aymar, Director of the International Thermonuclear Experimental Reactor (ITER), was nominated to succeed Professor Luciano Maiani as CERN's Director General, to take office on 1 January 2004.

CERN Document Server

2002-01-01

Dr Robert Aymar, Director of the International Thermonuclear Experimental Reactor (ITER), was nominated to succeed Professor Luciano Maiani as CERN's Director General, to take office on 1 January 2004.

White goddess--the unspeakable name. An inquiry into Robert Graves' King Jesus.

Science.gov (United States)

Nakano, N

1984-03-01

Robert Graves is a poet-mythographer, well-known in the U. K. and the U. S. A., but not in Japan despite his huge amount of poetic, mythographical, prose and critical works. Furthermore, even in the U. S. A. and the U. K., some people have been shunning him politely as a versatile iconoclast possessed of the White Goddess. In fact, it is not difficult to imagine that when King Jesus, a life story of Christ, was published, people were shocked at his extraordinary mythographical Christology derived from his enthusiasm towards the White Goddess Cult. In Christ he discovered the fragments of maternal doctrine as a new concept in opposition to the Apollonian theory of Judaism, but they seemed to be quite incomplete in the author's eyes lacking in something most essential in life, recognition of love and hatred discipline. This paper is an inquiry into how the author developed his own hermaneutics of Christ through his wide and thorough scholarship on mythology, history, the Bible and Celtic poetry.

The discovery of microorganisms by Robert Hooke and Antoni Van Leeuwenhoek, fellows of the Royal Society.

Science.gov (United States)

Gest, Howard

2004-05-01

The existence of microscopic organisms was discovered during the period 1665-83 by two Fellows of The Royal Society, Robert Hooke and Antoni van Leeuwenhoek. In Micrographia (1665), Hooke presented the first published depiction of a microganism, the microfungus Mucor. Later, Leeuwenhoek observed and described microscopic protozoa and bacteria. These important revelations were made possible by the ingenuity of Hooke and Leeuwenhoek in fabricating and using simple microscopes that magnified objects from about 25-fold to 250-fold. After a lapse of more than 150 years, microscopy became the backbone of our understanding of the roles of microbes in the causation of infectious diseases and the recycling of chemical elements in the biosphere.

Sobre o Conceito de Justiça em John Rawls e Robert Nozick

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Keberson Bresolin

2015-03-01

Full Text Available O presente artigo tem como objetivo apresentar o pensamento e o conceito de justiça como equidade presente na obra Uma Teoria da Justiça (1971 de John Rawls. Para isso, demonstraremos como o autor relaciona os conceitos de posição original e véu de ignorância como procedimento da escolha racional. Além disso, pretendemos apresentar também o conceito de justiça presente na obra Anarquia, estado e utopia (1974 de Robert Nozick. Por isso, abordaremos a concepção libertária nozickiana dos direitos individuais e o estado mínimo, o qual deve ser fundamentado para proteger estes direitos. Desta forma, procederemos expondo os princípios que subjazem no pensamento político de ambos os autores e como estes constroem seu arcabouço conceitual. Ao fazer isso, colocaremos as duas propostas em diálogo.

Muuseumid kaubamajadeks? / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

Võib juhtuda, et Tate Gallery on sunnitud müüma teoseid oma kollektsioonist katmaks Tate Moderni loomisega kaasnenud kulusid. Sothebys tulevad 25. IV müügile 350 XX sajandi alguse Edward Steicheni, Walker Evansi, Alfred Stieglitzi, EugèneAtgeti, Man Ray fotot New Yorgi MOMA kogudest

Predictive factors for the success of McRoberts' manoeuvre and suprapubic pressure in relieving shoulder dystocia: a cross-sectional study.

Science.gov (United States)

Lok, Zara Lin Zau; Cheng, Yvonne Kwun Yue; Leung, Tak Yeung

2016-10-29

McRoberts' and suprapubic pressure are often recommended as the initial choices of manoeuvres to manage shoulder dystocia, as they are believed to be less invasive compared to other manoeuvres. However, their success rates range from 23 to 40 %. This study aims to investigate the predictive factors for the success of McRoberts' manoeuvre with or without suprapubic pressure (M+/-S). All cases of shoulder dystocia in a tertiary hospital in South East Asia were recruited from 1995 to 2009. Subjects were analysed according to either 'success' or 'failure' of M+/-S. Maternal and fetal antenatal and intrapartum factors were compared by univariate and multivariate analysis. Among 198 cases of shoulder dystocia, M+/-S as the primary manoeuvre was successful in 25.8 %. The other 74.2 % needed either rotational or posterior arm manoeuvres or combination of manoeuvres. Instrumental delivery was the single most significant factor associated with an increased risk of failed M+/-S on logistic regression (p dystocia occurred after instrumental delivery but was 47.7 % after spontaneous vaginal delivery. When shoulder dystocia occurs after instrumental vaginal delivery, the chance of failure of M+/-S is 85 %, which is 4.7 times higher than that after spontaneous vaginal delivery. Hence all operators performing instrumental delivery should be proficient in performing all manoeuvres to relieve shoulder dystocia when M+/-S cannot do so.

Una época de frío moral: La sociología comunitarista de Robert N. Bellah

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HELENA BÉJAR

1996-01-01

Full Text Available A partir de la actualidad del comunitarismo, el presente artículo plantea un análisis crítico de la obra de Robert N. Bellah, uno de los líderes de dicho movimiento intelectual y político. así, se tratan las diversas tradiciones que conforman los valores de la vida pública y privada de los americanos, tales como el individualismo o la ciudadanía. el artículo desbroza también los diversos sentidos del término "comunidad", como parte de una urdimbre teórica que se contrapone al liberalismo utilitario.

Distribution and origin of authigenic smectite clays in Cape Roberts Project Core 3, Victoria Land Basin, Antarctica

Science.gov (United States)

Priestas, A.W.; Wise, S.W.

2007-01-01

Of some 800 m of lower Oligocene marine sediments cored continuously from the seafloor in the Victoria Land Basin of Antarctica at Cape Roberts Site CRP-3, the lower 500 m exhibit authigenic smectite clay coats on shallow-water sandstone grains. A scanning electron microscope/EDS study of 46 fracture sections confirms that the distribution of the clay coats through the unit is not uniform or evenly distributed, but rather varies with depth, original porosity, and the kinds and abundance of source materials. Our results suggest that smectite emplacement resulted from in-situ, low-temperature burial diagenesis rather than hydrothermal or fault-focused thermobaric fluids.

Sobre la obra de Robert M. MacIver. La acción social entre la comunidad y el Estado

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Herrera Gómez, Manuel

2004-12-01

Full Text Available Sociology, science and political philosophy are the disciplinary fields that have guided Robert M. Maclver's investigation. This is based on accurate intuition always present in his thought: to study human social action in order to set up a realistic theory on democracy with important federal contents by reason of an understanding of the relation between society and state. At this relation, state is a simple mean belonging to the sphere of civilization and society is an original reality (a "network of groups and communities", in which the primary interests of any social being are expressed.

Sociología, ciencia y filosofía política son los ámbitos disciplinares que han guiado y alimentado, compenetrándose, la investigación de Robert M. Maclver. Todo esto es debido a una intuición bien precisa que está presente en la base de su pensamiento: estudiar la acción social para fundar una teoría realista de la democracia con importantes contenidos federales en virtud de una concepción de la relación entre sociedad y Estado en la que este último es un simple medio perteneciente a la esfera de la civilización respecto a la sociedad entendida como realidad originaria (como red de grupos y comunidades, en la que se constituyen y encuentran expresión los intereses primarios de todo ser social.

Comparison of Two Kinds of 64Cu Labelled Octreotide Analogues

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HAN Zhen-yi1;LIANG Ji-xin1;HU Ji2;LUO Hong-yi1;QING Jing2;CHEN Yu-qing2;LI Guang2;LI Hong-yu1,2

2016-10-01

Full Text Available Octreotide analogues DOTA-TOC and DOTA-TATE were labeled with 64Cu. The influences of the ratio of peptide mass to 64Cu activity, pH value, temperature and reaction time on labeling yield were investigated. The optimum labeling was determined. In vitro stability tests in saline and 10% bovine serum had been carried out. Biodistribution of the two radiolabelled compounds in normal mice and Micro PET imaging in nude mice bearing U87MG tumor had been evaluated. The results showed that the labeling yields of 64Cu-DOTA-TOC and 64Cu-DOTA-TATE were higher than 95%. Two kinds of octreotide analogues labeled with 64Cu were quite stable in saline and decomposed slowly in 10% bovine serum at 37 ℃. Biodistribution results in normal mice showed that two 64Cu labelled tracers had similar profiles. Both of the compounds washed out from the blood quickly. High uptake of radioactivity in liver and kidneys indicated the tracers were excreted via both hepatobiliary system and renal system. At the same time, compared to 64Cu-DOTA-TOC, higher radioactivity accumulation of 64Cu-DOTA-TATE in liver and kidneys was observed. Micro PET images of U87MG tumor-bearing nude mice with 64Cu-DOTA-TOC and 64Cu-DOTA-TATE showed the tumors very clearly. The radioactivity uptake of 64Cu-DOTA-TATE in tumor was higher than that of 64Cu-DOTA-TOC. This work has paved the way for further preclinical and clinical application of 64Cu-DOTA-TOC and 64Cu-DOTA-TATE as PET tumor imaging agents.

A Multicultural Glimpse of Rural and Urban Adolescence in Robert Newton Peck's "A Day No Pigs Would Die" and Paul Zindel's "The Pigman."

Science.gov (United States)

Agnello, Mary Frances Linden

"A Day No Pigs Would Die" by Robert Newton Peck and "The Pigman" by Paul Zindel are 2 short novels that offer treasures in the form of many lessons in life to share in the language arts classroom. These two rich novels can serve as sources for multicultural understanding of rural and urban life, as well as for interpreting the…

Topics in cohomology of groups

CERN Document Server

Lang, Serge

1996-01-01

The book is a mostly translated reprint of a report on cohomology of groups from the 1950s and 1960s, originally written as background for the Artin-Tate notes on class field theory, following the cohomological approach. This report was first published (in French) by Benjamin. For this new English edition, the author added Tate's local duality, written up from letters which John Tate sent to Lang in 1958 - 1959. Except for this last item, which requires more substantial background in algebraic geometry and especially abelian varieties, the rest of the book is basically elementary, depending only on standard homological algebra at the level of first year graduate students.

Number theory Diophantine problems, uniform distribution and applications : festschrift in honour of Robert F. Tichy’s 60th birthday

CERN Document Server

Grabner, Peter

2017-01-01

This volume is dedicated to Robert F. Tichy on the occasion of his 60th birthday. Presenting 22 research and survey papers written by leading experts in their respective fields, it focuses on areas that align with Tichy’s research interests and which he significantly shaped, including Diophantine problems, asymptotic counting, uniform distribution and discrepancy of sequences (in theory and application), dynamical systems, prime numbers, and actuarial mathematics. Offering valuable insights into recent developments in these areas, the book will be of interest to researchers and graduate students engaged in number theory and its applications.

Homage to Robert Hooke (1635-1703): new insights from the recently discovered Hooke Folio.

Science.gov (United States)

Gest, Howard

2009-01-01

Microorganisms were first observed by Robert Hooke and Antoni van Leeuwenhoek between 1665 and 1678. In 1665, Hooke published Micrographia, which depicted the details of 60 objects as seen in the microscope. One chapter was devoted to the microfungus Mucor, the first microbe observed by the human eye. Leeuwenhoek, despite having no scientific training, became the first to observe protozoa, red blood cells, the sperm cells of animals, and bacteria, which he described in numerous letters to the Royal Society of London. In 1677, Hooke became Secretary of the Royal Society and, in the same year, confirmed some of Leeuwenhoek's discoveries. The discovery in 2006 of more than 650 pages of Hooke's missing records (the "Hooke Folio") allows us to verify the proceedings of Royal Society meetings and promises to be an important new source of Hooke's views on the renaissance of science in the 17th century.

Memória digital e o futuro da comunicação: entrevista com Robert Darnton

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Aline Strelow

2013-06-01

Full Text Available Robert Darnton é diretor da Biblioteca da Universidade Harvard e referência internacional nos estudos de história da comunicação e história cultural. Dirige também, atualmente, a Digital Public Library of America, biblioteca digital lançada em abril de 2013, que reúne acervos de bibliotecas, arquivos e museus. Autor de dezenas de livros, nesta entrevista, ele fala sobre o desenvolvimento da DPLA, sobre os desafios enfrentados pelos projetos de digitalização, sobre o futuro do livro, do jornalismo e da pesquisa em história da comunicação diante das novas tecnologias. A entrevista foi realizada em outubro de 2012, no escritório do autor na Universidade Harvard.

Beck x Roberts: Comparativos do Diagrama do Metrô de Londres

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Joaquim Redig

2015-06-01

Full Text Available Este artigo foi originalmente dirigido à disciplina Design e Visualização da Informação, ministrada pelo Prof. André Monat no curso de Doutorado em Design da ESDI-UERJ, Escola Superior de Desenho Industrial da Universidade do Estado do Rio de Janeiro, em 2013, a partir da proposta do professor de se examinar a pertinência da estrutura radial proposta por Maxwell J. Roberts para o design de mapas de redes de transporte. No artigo, procuro demonstrar que, por ser uma forma padrão pré-convencionada e abstrata, não valorizando a relação visual analógica com o objeto representado – a rede geo-espacial do sistema de transporte, variável para cada cidade – a estrutura radial não facilita a compreensão e o uso da rede, relativamente ao sistema ortogonal/diagonal projetado por Harry Beck para o assim chamado Diagrama do metrô londrino, que, partindo do código mais universal e ancestral de orientação que é a Rosa dos Ventos, se baseia nos eixos dos percursos. Por isso, este sistema se tornou um paradigma mundial no campo do Design de Informação, ainda não superado.

The Value of the "Blueprint" Festival

Science.gov (United States)

Cawley-Gelling, India; Hyland, Steven; McCarron-Roberts, Connah; Noor, Sufea Mohamad; Morrissey, Ruth

2015-01-01

"Blueprint" was a three-day festival which took place at Tate Liverpool in July 2014 and was organised and produced by Tate Collective Liverpool, as part of "Circuit", a four-year national programme connecting 15-25 year olds to the arts. "Circuit" aims to be open, reflective and critical and bring about…

[Robert Schweitzer. Eine Unveröffentlichte Quelle zur Schulgeschichte von Reval Ferdinand Wiedemanns Geschichte des Revaler Gouvernementsgymnasiums aus dem Jahr 1856] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2008-01-01

Arvustus: Robert Schweitzer. Eine Unveröffentlichte Quelle zur Schulgeschichte von Reval Ferdinand Wiedemanns Geschichte des Revaler Gouvernementsgymnasiums aus dem Jahr 1856. - Buch und Bildung im Baltikum. Münster : LIT, 2005. lk. 495-525. Kubermangugümnaasiumi vanemõpetaja Ferdinand Wiedemann kirjutas 1856. aastal kooli ajaloo, mis mingitel põhjustel jäi avaldamata. Tema tööd on kasutanud 1881. aastal Gotthard von Hansen

Celebrando São Besso ou o que Robert Hertz e a Escola Francesa de Sociologia têm a nos dizer sobre festas, rituais e simbolismo

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Renata de Castro Menezes

2009-01-01

Full Text Available Este artigo apresenta reflexões sobre as possibilidades e as dificuldades do estudo de festas religiosas através da interpretação de um texto de Robert Hertz (um dos pesquisadores da Escola Francesa de Sociologia, originalmente publicado em 1913, que versa sobre a festa de São Besso, um evento religioso que ocorre nos alpes italianos. O objetivo do presente trabalho é destacar as pistas que Hertz deixou abertas em seu estudo e sugerir maneiras de nos apropriarmos de seus insights em nossas análises atuais.This article presents some reflections about the possibilities and difficulties in the study of religious festivals. It does so by reinterpreting a text written by Robert Hertz, one of the researches of the French School of Sociology. It is a text about Saint Besso’s festival, originally published in 1913. The aim of the article is to stress some of the clues that Hertz opened with his work and to suggest how his insights can be useful for our own analyses about festivals.

Preclinical evaluation of somatostatin analogs bearing two macrocyclic chelators for high specific activity labeling with radiometals

International Nuclear Information System (INIS)

Storch, D.; Schmitt, J.S.; Waldherr, C.; Maecke, H.R.; Waser, B.; Reubi, J.C.

2007-01-01

Radiometallated analogues of the regulatory peptide somatostatin are of interest in the in vivo localization and targeted radiotherapy of somatostatin receptor-overexpressing tumors. An important aspect of their use in vivo is a fast and efficient labeling (complexation) protocol for radiometals along with a high specific activity. We describe in this manuscript synthetic methods for the coupling of two chelators (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid = DOTA) to the bioactive peptide [Tyr 3 ,Thr 8 ]-octreotide (TATE) in order to increase the specific activity (radioactivity in Bq per mole peptide). The full chelator-linker-peptide conjugate was assembled on solid support using standard Fmoc chemistry. Two DOTA-chelators were linked to the peptide using lysine or N,N'-bis(3-aminopropyl)-glycine (Apg); in addition, pentasarcosine (Sar 5 ) was used as a spacer between the chelators and the peptide to probe its influence on biology and pharmacology. Complexation rates with In 3+ and Y 3+ salts and the corresponding radiometals were high, the bis-DOTA-derivatives showed higher complexation rates and gave higher specific activity than DOTA-TATE. Pharmacological and biological data of the complexed molecules did not show significant differences if compared to the parent peptide [ 111/nat In-DOTA]-TATE except for [( 111/nat In-DOTA) 2 -Apg]-TATE which showed a lower binding affinity and rate of internalization into tumor cells. The biodistribution of [( 111/nat In-DOTA)-Lys( 111/nat In-DOTA)]-TATE in the rat tumor model (AR4-2J) showed a high and specific (as shown by a blocking experiment) tracer uptake in somatostatin receptor-positive tissue but a lower tumor uptake compared to [ 111/nat In-DOTA]-TATE. (orig.)

Contemporary Studies Network Roundtable: Responding to Robert Macfarlane’s ‘Generation Anthropocene’

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Rachel Sykes

2017-02-01

Full Text Available In April 2016, 'The Guardian' published ‘Generation Anthropocene: How humans have altered the planet forever’ by the celebrated academic and nature writer Robert Macfarlane. Reflecting on the article’s importance as a critical experiment and, perhaps, a vital form of public engagement, Contemporary Studies Network (CSN asked six of its members, working across very different areas of literary and cultural studies, to respond to and extend Macfarlane’s article, mapping the different ways in which literary scholars might approach the age of the Anthropocene. Conducted via email, this roundtable conversation asks to what extent the Anthropocene marks a new era in literary criticism, how exactly it extends preexisting strands of ecocriticism and trauma studies, and what the global scope of the term might be beyond the confines of the Western literary canon. Discussion ranges from issues of temporality to genre and form and it also addresses Macfarlane’s rhetoric, his call to arms for those working in the humanities, for a more comprehensive investigation in to the roles of literature and art in responding to and representing what may become a new epoch.

A capital Scot: microscopes and museums in Robert E. Grant's zoology (1815-1840).

Science.gov (United States)

Quick, Tom

2016-06-01

Early nineteenth-century zoology in Britain has been characterized as determined by the ideological concerns of its proponents. Taking the zoologist Robert E. Grant as an exemplary figure in this regard, this article offers a differently nuanced account of the conditions under which natural-philosophical knowledge concerning animal life was established in post-Napoleonic Britain. Whilst acknowledging the ideological import of concepts such as force and law, it points to an additional set of concerns amongst natural philosophers - that of appropriate tool use in investigation. Grant's studies in his native Edinburgh relied heavily on the use of microscopes. On his arrival in London, however, he entered a culture in which a different set of objects - museum specimens - held greater persuasive power. This article relates changes in Grant's ideas and practices to the uneven emphases on microscopic and museological evidence amongst European, Scottish and English natural philosophers at this time. In so doing, it identifies the reliance of London-based natural philosophers on museology as constituting a limiting effect on the kinds of claim that Grant sought to make regarding the nature of life.

Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer.

Science.gov (United States)

Mitragotri, S

2013-01-01

Transdermal drug delivery continues to provide an advantageous route of drug administration over injections. While the number of drugs delivered by passive transdermal patches has increased over the years, no macromolecule is currently delivered by the transdermal route. Substantial research efforts have been dedicated by a large number of researchers representing varied disciplines including biology, chemistry, pharmaceutics and engineering to understand, model and overcome the skin's barrier properties. This article focuses on engineering contributions to the field of transdermal drug delivery. The article pays tribute to Prof. Robert Langer, who pioneered the engineering approach towards transdermal drug delivery. Over a period spanning nearly 25 years since his first publication in the field of transdermal drug delivery, Bob Langer has deeply impacted the field by quantitative analysis and innovative engineering. At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field. © 2013 S. Karger AG, Basel.

Challenging Expertise: Paul Feyerabend vs. Harry Collins & Robert Evans on democracy, public participation and scientific authority: Paul Feyerabend vs. Harry Collins & Robert Evans on scientific authority and public participation.

Science.gov (United States)

Sorgner, Helene

2016-06-01

This paper compares Feyerabend's arguments in Science in a Free Society to the controversial theory of expertise proposed by Harry Collins and Robert Evans as a Third Wave of Science Studies. Is the legitimacy of democratic decisions threatened by the unquestioned authority of scientific advice? Or does, on the contrary, science need protection from too much democratic participation in technical decisions? Where Feyerabend's political relativism envisions democratic society as inherently pluralist and demands equal contribution of all traditions and worldviews to public decision-making, Collins and Evans hold a conception of elective modernism, defending the reality and value of technical expertise and arguing that science deserves a privileged status in modern democracies, because scientific values are also democratic values. I will argue that Feyerabend's political relativism provides a valuable framework for the evaluation of Collins' and Evans' theory of expertise. By constructing a dialog between Feyerabend and this more recent approach in Science and Technology Studies, the aim of this article is not only to show where the two positions differ and in what way they might be reconciled, but also how Feyerabend's philosophy provides substantial input to contemporary debate. Copyright © 2015 Elsevier Ltd. All rights reserved.

A collection of publications and articles for a light water ultra-safe plant concept

International Nuclear Information System (INIS)

Klevans, E.H.

1988-01-01

This collection contains reports titled: ''The Penn State Ultra-Safe Reactor Concept; '' ''Ultra Safe Nuclear Power; '' ''Use of the Modular Modeling System, in the Design of the Penn State Advanced Light Water Reactor; '' ''Use of the Modular Modeling System in Severe Transient Analysis of Penn State Advanced Light Water Reactor; '' ''PSU Engineers' Reactor Design May Stop a Future TMI; '' and ''The Penn State Advanced Light Water reactor Concept.''

BASEMAP, Tate COUNTY, MS

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

O PROCESSO CRIATIVO EM THE BROTHER, DE ROBERT COOVER: UMA RELEITURA DO SAGRADO NA CONTEMPORANEIDADE

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Fernanda Aquino Sylvestre

2014-05-01

Full Text Available Robert Coover é um importante escritor norte-americano preocupado com as perspectivas sociais, psicológicas, econômicas e políticas contemporâneas e com o modo como elas se configuram na formação da sociedade do seu país. Essa preocupação se reflete tanto nas técnicas de construção de suas histórias, quanto nas críticas apresentadas em suas narrativas. O trabalho em questão discute a reescrita que Coover faz de mitos bíblicos dentro do contexto pós-moderno, globalizado, compondo novos textos que subvertem os elementos tradicionais da narrativa. Mais especificamente, este artigo analisa a reescrita que o autor norte-americano empreende acerca da passagem bíblica da Arca de Noé no conto “The Brother”.

Les « Photo Poche » de Robert Delpire : un exemple d’édition culturelle

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Gaëlle Morel

2010-06-01

Full Text Available « Accessible, maniable, élégante, soigneusement photogravée et imprimée », la collection « Photo Poche » de Robert Delpire apparaît vingt-cinq ans après sa création comme une grande réussite éditoriale. Fondée en 1982 et subventionnée à l’époque par le ministère de la Culture, la série des petits livres noirs constitue également un objet emblématique du processus de légitimation culturelle de la photographie en France. Éditeur expérimenté, Delpire est nommé à la tête de la principale institut...

The work of Charles Rennie Mackintosh and Robert Lorimer within national and international tendencies in design at the turn of the century [dissertation

OpenAIRE

Milne, Jason E.

1992-01-01

This dissertation examines the designs of two of Scotland's most important architects, Charles Rennie Mackintosh and Robert Lorimer, based in Glasgow and Edinburgh respectively at the turn of the century. Their work is viewed in relation to international tendencies in progressive architecture and design, namely the Arts and Crafts Movement; also in relation to the existing strand of Romanticism in Scotland and the Scottish Baronial Revival which in some respects reported a particular manifest...

Comparing two maps by Geographer Robert de Vaugondy that represent the Kingdom of Portugal in the 18th century (1751 with the current mapping of the country as regards its topography, hydrography, shoreline definition and settlements

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Marco Pais Neves Dos Santos

2014-07-01

Full Text Available In our paper “Estudo de dois Mapas do Geografo Robert de Vaugondy relativos ao Reino de Portugal do Século XVIII (1751” (Study on two maps by Geographer Robert de Vaugondy representing the Kingdom of Portugal in the 18th century, published in Revista Semina: Ciências Sociais e Humanas, Vol. 34, Issue No 1, 2013, we tried to give an explanation for the administrative divisions that appear in those maps. After having studied a number of texts dedicated to the period in question and other related documents, we came to the conclusion that the most logic explanation for those divisions is that they represent ecclesiastical divisions. In this paper, we go further in our analysis and compare these two maps with some current maps of Portugal, taking into account its topography, hydrography, shoreline definition and settlements. Although there are some errors in his maps, we can conclude that Robert de Vaugondy’s work, in terms of his knowledge and geographic representation of Portugal, was the best anyone could do at the time, and we restate the idea that the two maps represent ecclesiastical divisions.

Seeking a Second Opinion: Robert McNamara’s Distrust of the U.S. Intelligence Community During Operation Rolling Thunder

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Thomas A. Reinstein

2016-04-01

Full Text Available Thomas A. Reinstein reexamines how military intelligence was evaluated and employed during the Vietnam War, especially by Secretary of Defense Robert McNamara. Reinstein takes a relatively unexplored approach by delving into the Secretary’s personal policy predilections and efforts to retain cabinet influence as factors determining his use of intelligence reports. These considerations guided his changing positions on the bombing campaign known as Rolling Thunder. The article’s focus on personal considerations in policy making adds complexity to our views of decision making but also raises very serious concerns about the flawed nature of those processes and the dangers of miscalculation at the highest levels of government.

Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department

Energy Technology Data Exchange (ETDEWEB)

Colby, Eric R.; Hogan, Mark J.; /SLAC

2011-11-14

Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As the department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.

Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department

International Nuclear Information System (INIS)

Colby, Eric R.; Hogan, Mark J.

2008-01-01

Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As the department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.

EDITORIAL: Roberts Prize for the best paper published in 2012 Roberts Prize for the best paper published in 2012

Science.gov (United States)

Cherry, Simon; Ruffle, Jon

2013-08-01

The publishers of Physics in Medicine and Biology (PMB), IOP Publishing, in association with the journal owners, the Institute of Physics and Engineering in Medicine (IPEM), jointly award the Roberts prize for the best paper published in PMB during the previous year. The procedure for deciding the winner is a two-stage process. First, a shortlist of contenders is drawn up based on those papers that had the best referees' quality assessments, with a further quality check and endorsement by the Editorial Board. The papers on the shortlist are then reviewed by a specially convened IPEM committee consisting of members with fellow status. This committee reads the shortlisted papers and selects the winner. We have much pleasure in advising readers that the Roberts Prize for the best paper published in 2012 is awarded to Michel Defrise, Ahmadreza Rezaei and Johan Nuyts from the Vrije Universiteit Brussels and the Katholieke Universiteit Leuven, Belgium for their breakthrough paper that describes how the information needed for attenuation correction in PET imaging can be extracted, to within a constant, from time-of-flight emission data: Time-of-flight PET data determine the attenuation sinogram up to a constant 2012 Phys. Med. Biol. 57 885 Michel Defrise1, Ahmadreza Rezaei2 and Johan Nuyts2 1Department of Nuclear Medicine, Vrije Universiteit Brussel, B-1090 Brussels, Belgium 2Department of Nuclear Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium This paper represents an important and timely contribution to the literature as time-of-flight PET scanners are now offered by several manufacturers. In hybrid PET/CT scanners, the PET attenuation correction, necessary for quantitative reconstruction of the tracer distribution, can be derived directly from the CT data. Sometimes, however, the PET and CT scans may be poorly aligned due to patient motion and other approaches are needed. In addition, hybrid PET/MRI scanners also, have been developed recently, and in

Apparent target strength in long-rod penetration

Energy Technology Data Exchange (ETDEWEB)

Godwin, R.P.; Chapyak, E.J. [Los Alamos National Lab., NM (United States). Applied Theoretical and Computational Physics Div.

1996-03-01

The authors investigate the apparent enhancement of target strength in the steady-state Tate model of long-rod penetration. They show that computing the effective area over which the target behaves as a fluid provides an explanation of the effective 1-D target strength measured empirically. Expressing the effective target strength as R{sub t} = a {times} Y{sub t}, they postulate that a = A{sub e}/A{sub p}, where Y{sub t} is the nominal strength; A{sub e} is the effective target fluid cross-sectional area and A{sub p} the projectile cross-sectional area. For the case of a rod and projectile of the same material, they use the Tate model together with the jet model of Birkhoff et al. to show a {approx} 4 is likely. Simultaneously satisfying Newton`s Second Law and the Tate model yields a very general derivation of a = 4. By explicitly including strength terms in both the Tate equation and Newton`s Second Law, an even more general a = f(v,{rho}{sub p},{rho}{sub t},Y{sub p},Y{sub t}) can be derived.

Diversity dynamics: The experience of male Robert Wood Johnson Foundation nurse faculty scholars.

Science.gov (United States)

Brody, Abraham A; Farley, Jason E; Gillespie, Gordon L; Hickman, Ronald; Hodges, Eric A; Lyder, Courtney; Palazzo, Steven J; Ruppar, Todd; Schiavenato, Martin; Pesut, Daniel J

Managing diversity dynamics in academic or clinical settings for men in nursing has unique challenges resulting from their minority status within the profession. The purpose of this study was to share challenges and lessons learned identified by male scholars in the Robert Wood Johnson Foundation Nurse Faculty Scholars program and suggest strategies for creating positive organizations promoting inclusive excellence. Multiple strategies including informal mentored discussions and peer-to-peer dialogue throughout the program, formal online surveys of scholars and National Advisory Committee members, and review of scholar progress reports were analyzed as part of the comprehensive evaluation plan of the program. Diversity dynamic issues include concerns with negative stereotyping, microaggression, gender intelligence, and differences in communication and leadership styles. Male nurse faculty scholars report experiencing both opportunities and challenges residing in a predominately female profession. This article attempts to raise awareness and suggest strategies to manage diversity dynamics in service of promoting the development of a culture of health that values diversity and inclusive excellence for both men and women in academic, research, and practice contexts. Copyright © 2017 Elsevier Inc. All rights reserved.

The two faces of Robert Fitzroy, Captain of HMS Beagle and governor of New Zealand.

Science.gov (United States)

Paul, Diane B; Stenhouse, John; Spencer, Hamish G

2013-09-01

Robert FitzRoy, Captain of HMS Beagle and second governor of New Zealand, has two contradictory reputations among modern academics. Evolutionary biologists and Darwin scholars generally view FitzRoy as a supporter of slavery, famously quarrelling with the abolitionist Darwin over that topic during a Brazilian stopover early in the voyage of HMS Beagle. He is also regarded as a political and religious reactionary, taking a biblically creationist position at the infamous 1860 Oxford meeting of the British Association for the Advancement of Science. New Zealand historians, however, view his record as governor much more positively. They emphasize that FitzRoy was wildly unpopular with the British settlers because of his enlightened insistence that the native Maori should be treated fairly. We outline the history of these seemingly inconsistent views and examine the evidence for each. We conclude by suggesting that a more nuanced account of FitzRoy's career would surely be more thought-provoking as well as respectful of the facts.

An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial.

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Martyn Lewis

Full Text Available The TATE trial was a multicentre pragmatic randomized controlled trial of supplementing primary care management (PCM-consisting of a GP consultation followed by information and advice on exercises-with transcutaneous electrical nerve stimulation (TENS, to reduce pain intensity in patients with tennis elbow. This paper reports the health economic evaluation.Adults with new diagnosis of tennis elbow were recruited from 38 general practices in the UK, and randomly allocated to PCM (n = 120 or PCM plus TENS (n = 121. Outcomes included reduction in pain intensity and quality-adjusted-life-years (QALYs based on the EQ5D and SF6D. Two economic perspectives were evaluated: (i healthcare-inclusive of NHS and private health costs for the tennis elbow; (ii societal-healthcare costs plus productivity losses through work absenteeism. Mean outcome and cost differences between the groups were evaluated using a multiple imputed dataset as the base case evaluation, with uncertainty represented in cost-effectiveness planes and through probabilistic cost-effectiveness acceptability curves. Incremental healthcare cost was £33 (95%CI -40, 106 and societal cost £65 (95%CI -307, 176 for PCM plus TENS. Mean differences in outcome were: 0.11 (95%CI -0.13, 0.35 for change in pain (0-10 pain scale; -0.015 (95%CI -0.058, 0.029 for QALYEQ5D; 0.007 (95%CI -0.022, 0.035 for QALYSF6D (higher score differences denote greater benefit for PCM plus TENS. The ICER (incremental cost effectiveness ratio for the main evaluation of mean difference in societal cost (£ relative to mean difference in pain outcome was -582 (95%CI -8666, 8113. However, incremental ICERs show differences in cost-effectiveness of additional TENS, according to the outcome being evaluated.Our findings do not provide evidence for or against the cost-effectiveness of TENS as an adjunct to primary care management of tennis elbow.

Dr. Robert G. Heath: a controversial figure in the history of deep brain stimulation.

Science.gov (United States)

O'Neal, Christen M; Baker, Cordell M; Glenn, Chad A; Conner, Andrew K; Sughrue, Michael E

2017-09-01

The history of psychosurgery is filled with tales of researchers pushing the boundaries of science and ethics. These stories often create a dark historical framework for some of the most important medical and surgical advancements. Dr. Robert G. Heath, a board-certified neurologist, psychiatrist, and psychoanalyst, holds a debated position within this framework and is most notably remembered for his research on schizophrenia. Dr. Heath was one of the first physicians to implant electrodes in deep cortical structures as a psychosurgical intervention. He used electrical stimulation in an attempt to cure patients with schizophrenia and as a method of conversion therapy in a homosexual man. This research was highly controversial, even prior to the implementation of current ethics standards for clinical research and often goes unmentioned within the historical narrative of deep brain stimulation (DBS). While distinction between the modern practice of DBS and its controversial origins is necessary, it is important to examine Dr. Heath's work as it allows for reflection on current neurosurgical practices and questioning the ethical implication of these advancements.

Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome

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Petra van der Lelij

2010-01-01

Full Text Available Fanconi anemia (FA is a recessively inherited disease characterized by multiple symptoms including growth retardation, skeletal abnormalities, and bone marrow failure. The FA diagnosis is complicated due to the fact that the clinical manifestations are both diverse and variable. A chromosomal breakage test using a DNA cross-linking agent, in which cells from an FA patient typically exhibit an extraordinarily sensitive response, has been considered the gold standard for the ultimate diagnosis of FA. In the majority of FA patients the test results are unambiguous, although in some cases the presence of hematopoietic mosaicism may complicate interpretation of the data. However, some diagnostic overlap with other syndromes has previously been noted in cases with Nijmegen breakage syndrome. Here we present results showing that misdiagnosis may also occur with patients suffering from two of the three currently known cohesinopathies, that is, Roberts syndrome (RBS and Warsaw breakage syndrome (WABS. This complication may be avoided by scoring metaphase chromosomes—in addition to chromosomal breakage—for spontaneously occurring premature centromere division, which is characteristic for RBS and WABS, but not for FA.

Folk Narratives and the Reflection of (UTU Humanness in Shaaban Robert Adili na Nduzuze

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J.P. Madoshi

2015-08-01

Full Text Available This paper examines the novel Adili na Nduguze by Shaaban Robert. It seeks to explain how humanness is embedded in the plot of this prose fiction. The study uses Utu/Ubuntu as a theory of analyzing and explaining the events and the actions within this novel. The focus of the paper is to explore the plot of the novel in order to see how it reflects humanness (Utu/Ubuntu as it is perceived among the Bantu. The analysis is done by examining the reason of characters appellation and the author attention to diction which shows how royal characters intervene a conflict within this creative work. Also the study examines the novel in order to provide an account of the ontological conflict of two opposing beliefs in which a city is turned into stones (Mji Uliogeuka Mawe. Lastly, the paper attempts to inspect and explain reasons why Hasidi and Mwivu, Adili two brothers are turned into baboons, subjected to severe whipping from Adili and the cause of the removal of the curse placed upon them which subsequently makes them humans again.

Book review: The man who saved the whooping crane: The Robert Porter Allen story

Science.gov (United States)

King, Sammy L.

2013-01-01

Kathleen Kaska has done a remarkable job of capturing the life of Robert Porter Allen, truly one of the premier biologist/conservationists of the twentieth century. Allen, born in 1905, grew up reading outdoor adventure books and playing in the woods of northern Pennsylvania with his brother. At a young age, he was encouraged to join the Junior Audubon club and his passion for ornithology soon crystallized. He attended Lafayette College to study ornithology, but he was disinterested in academics and fared poorly. He dropped out after two years and joined the Merchant Marines. Not an auspicious beginning for such a highly respected scientist and conservationist! Soon, however, he landed a librarian job with Audubon and his diligence, acumen, and communication skills allowed him to take more and more responsibilities. He became one of the youngest Audubon sanctuary directors ever appointed, and he was also able to secure a fellowship through Cornell to work on Roseate Spoonbills (Platalea ajaja). Audubon later appointed him to lead their Whooping Crane (Grus americana) studies.

CERN 50th Anniversary Official Celebration : welcome by CERN Director General Robert Aymar to French President Jacques Chirac, to King of Spain Juan Carlos and to President of the Swiss Confederation Joseph Deiss

CERN Multimedia

Patrice Loiez; Michel Blanc

2004-01-01

CERN 50th Anniversary Official Celebration : welcome by CERN Director General Robert Aymar to French President Jacques Chirac, to King of Spain Juan Carlos and to President of the Swiss Confederation Joseph Deiss

Robert Dicke and the naissance of experimental gravity physics, 1957-1967

Science.gov (United States)

Peebles, Phillip James Edwin

2017-06-01

The experimental study of gravity became much more active in the late 1950s, a change pronounced enough be termed the birth, or naissance, of experimental gravity physics. I present a review of developments in this subject since 1915, through the broad range of new approaches that commenced in the late 1950s, and up to the transition of experimental gravity physics to what might be termed a normal and accepted part of physical science in the late 1960s. This review shows the importance of advances in technology, here as in all branches of natural science. The role of contingency is illustrated by Robert Dicke's decision in the mid-1950s to change directions in mid-career, to lead a research group dedicated to the experimental study of gravity. The review also shows the power of nonempirical evidence. Some in the 1950s felt that general relativity theory is so logically sound as to be scarcely worth the testing. But Dicke and others argued that a poorly tested theory is only that, and that other nonempirical arguments, based on Mach's Principle and Dirac's Large Numbers hypothesis, suggested it would be worth looking for a better theory of gravity. I conclude by offering lessons from this history, some peculiar to the study of gravity physics during the naissance, some of more general relevance. The central lesson, which is familiar but not always well advertised, is that physical theories can be empirically established, sometimes with surprising results.

‘Bagley among the Germans’: Robert Bagley, Gombrich among the Egyptians and Other Essays in the History of Art, Seattle: Marquand Books, 2016

Directory of Open Access Journals (Sweden)

Andrei Pop

2016-12-01

Full Text Available Robert Bagley’s Gombrich among the Egyptians is an ambitious challenge to business as usual in the teaching and practice of art history, tackling subjects from style and iconography to pedagogy and cross-cultural comparison, all in light of an original account of artist’s materials and techniques centred on prehistoric China. The book concludes on a polemic confrontation with the Anglo-Austrian art historian E.H. Gombrich, which is flawed but offers plenty of grist for further thinking.

Métodos para superação da dormência de sementes de quixabeira (Sideroxylon obtusifolium (Roem. & Schult. T.D.Penn..

Directory of Open Access Journals (Sweden)

Ana Clara Moura Neves Rebouças

2012-03-01

Full Text Available http://dx.doi.org/10.5902/198050985090Devido à ausência de informações sobre a metodologia para avaliação da qualidade fisiológica de sementes das espécies arbóreas medicinais, o presente trabalho teve por objetivo determinar o método mais eficiente para superação da dormência tegumentar em sementes de Sideroxylon obtusifolium (Roem. & Schult. T.D.Penn.. Além das sementes intactas, sementes que não foram submetidas a nenhum tratamento, também foram utilizados os seguintes tratamentos pré-germinativos: escarificação química - as sementes foram imersas em ácido sulfúrico absoluto por 10, 20, 30, 40, 50 e 60 minutos; escarificação mecânica - as sementes foram friccionadas manualmente em lixa nº 50, do lado oposto à micrópila, sem ou com embebição por 24 ou 48 horas; imersão em água a 100ºC por 15 ou 30 segundos; imersão em água a 80ºC até o resfriamento. Os efeitos foram avaliados através de testes de germinação e vigor. Constatou-se que houve diferença significativa entre os tratamentos para todos os parâmetros avaliados (porcentagem e velocidade de germinação, comprimento e massa seca de parte aérea e raiz primária, e a causa mais evidente da dormência é a impermeabilidade do tegumento, a qual foi superada com maior eficiência pelo método de imersão em ácido sulfúrico por 30 minutos.

¿Qué significa pensar moralmente? Dos maneras actuales de entender a Kant: Robert B. Brandom y Jürgen Habermas

Directory of Open Access Journals (Sweden)

Martínez de Velasco, Luis

2004-06-01

Full Text Available Two hundred years often I. Kant's death, his influence grows more and more each day. The list of such past and present philosophers as have received, in a way or another, the Kantian heritage cannot be easily encompassed. Among them all, there are two outstanding philosophers whose intellectual origin -analytic philosophy and Frankfurtian thought respectively- would not in principle betray any Kantian lineage. However they have been able to reach a rare mustering of the problematic essence of Kant' s reflexion, chiefly as regards the self-grounding of counterfactual thought within the framework of a pragmatic-transcendental view of language use. We are referring to Robert B. Brandom and Jürgen Habermas.

A los doscientos años del fallecimiento de Immanuel Kant, su influencia no hace sino crecer cada día que pasa. La nómina de filósofos pasados y presentes que han recibido, de alguna manera, herencias kantianas resulta difícilmente abarcable con la mirada. De entre todos estos filósofos destacan dos cuyo origen -filosofía analítica y pensamiento frankfurtiano, respectivamente- no parece delatar, en principio, la filiación kantiana de su pensamiento. Y, sin embargo, pocos pensadores han logrado captar como ellos la esencia problemática de la reflexión de Kant, sobre todo en lo concerniente a la autofundamentación de un pensamiento contrafáctico en el marco de una consideración pragmático-transcendental del uso del lenguaje. Nos referimos a Robert B. Brandom y a Jürgen Habermas.

Les rites de la mort à Bornéo : séparation ou renaissance ? Actualité de Robert Hertz Death Rites in Borneo: Separation or Rebirth? Robert Hertz’ Legacy

Directory of Open Access Journals (Sweden)

Pascal Couderc

2012-12-01

Full Text Available La publication récente par le Borneo Research Council d’un ouvrage collectif sur la mort fournit l’occasion de réévaluer l’apport de Robert Hertz à la compréhension des rites funéraires à Bornéo. Si la traduction en anglais, dans les années 1960, de l’essai de Hertz sur la représentation collective de la mort avait consacré, grâce notamment aux travaux de Peter Metcalf sur les Berawan, la puissance du modèle analytique hertzien, ce nouvel ouvrage semble signaler que le moment de la célébration finale est venu, où les héritiers se libèrent de l’emprise spirituelle du défunt. Tout en conservant une grande part de sa valeur comme théorie du deuil, le paradigme transitionnel ou « réactif » de Hertz révèle ses limites, mises ici en lumière par des données ethnographiques encore peu connues ou inédites, qui démontrent, par exemple, l’existence d’une circulation des composantes de la personne par delà l’opposition entre la vie et la mort, ou encore l’influence directe des secondes funérailles sur la renaissance des défunts. Cet article aborde le dépassement du modèle hertzien en retournant à la lettre de l’essai, dont il met en relief l’intelligence ethnographique et la finesse théorique.The recent publication by the Borneo Research Council of a collection of essays on death provides an opportunity to reassess the heritage of Robert Hertz, whose theory of the double obsequies relies heavily on the ethnography of the Ngaju and other Borneo peoples. The translation of Hertz’s essay on the collective representation of death in the 1960s, prompting in particular Peter Metcalf’s work on the Berawan, has consecrated the explanatory power of Hertz’s model. With this new book, however, time seems to have come for the final celebration that marks the heirs’ liberation from the deceased’s spiritual influence. While still largely valid as a general theory of mourning, Hertz’s paradigm of

Théorie mathématique des catégories en biologie et notion d'équivalence naturelle chez Robert Rosen

OpenAIRE

Varenne , Franck

2011-01-01

L'objectif de cet article est de rendre compte de la justification épistémologique de la proposition faite, dès 1958, par le biomathématicien Robert Rosen d'introduire le concept mathématique de " catégorie " et celui - corrélatif - d'" équivalence naturelle " dans la modélisation mathématique appliquée au vivant. Nos questions sont les suivantes : en quoi la notion mathématique de catégorie permet-elle, selon Rosen, de donner accès à des formalismes plus " naturels " pour la modélisation du ...

Obituary: Ralph Robert Robbins, Jr., 1938-2005

Science.gov (United States)

Hemenway, Mary Kay; Jefferys, William H.; Lambert, David L.

2007-12-01

Ralph Robert Robbins, Jr., died on 2 December 2005, in Kyle, Texas. His wife, Maria Elena Robbins, his daughters Julia Robbins Kelso and Stephanie Juarez Balles, his son Matthew Juarez, and five grandchildren survive him. Bob was on the faculty at the University of Texas from 1968 until his retirement in 2003. Bob was born in Wichita, Kansas, on 2 September 1938, the only son of Mildred and Ralph Robert Robbins, Sr. Guided by his high school's policy to provide a practical education to children of working-class parents, Bob began high school with a heavy dose of vocational courses until the results of a test indicated his special talent in mathematics. He was awarded a full scholarship to Yale University, graduating magna cum laude in mathematics in 1960. He won the Warner Prize in Mathematics at Yale that year. He received his Ph.D. in 1966 with a dissertation entitled "The Triplet Spectrum of Neutral Helium in Expanding Nebulae" from the University of California at Berkeley. His interest in college teaching was ignited at this time through summer teaching positions at San Mateo California Junior College and the Ohio State University. Following a year at Texas as a McDonald Observatory Post-doctoral Fellow, Bob taught for a year in the physics department of the University of Houston before returning to the University of Texas at Austin as an Assistant Professor of Astronomy in 1968. He was promoted to Associate Professor in 1972. Bob's research in the early 1970s on theoretical studies of helium was of vital importance to astronomers for over three decades. These pioneering calculations became vital to observational astronomers in the mid-1990s as interest grew in the primordial helium produced by the Big Bang. Bob's interest and influence in education was international in scope. In the summers 1968-1970, he was a government consultant in Mathematics in East Pakistan (now Bangladesh). He consulted with the government that was preparing a master plan for technical

Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

CERN Multimedia

Claudia Marcelloni

2007-01-01

Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

The Penn Polarimeters

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Robert H. Koch

2012-03-01

Full Text Available This report describes the inception, development and extensive use over 30 years of elliptical polarimeters at the University of Pennsylvania. The initial Mark I polarimeter design utilized oriented retarder plates and a calcite Foster-Clarke prism as the analyzer. The Mark I polarimeter was used on the Kitt Peak 0.9 m in 1969-70 to accomplish a survey of approximately 70 objects before the device was relocated to the 0.72 m reflector at the Flower and Cook Observatory. Successive generations of automation and improvements included the early-80’s optical redesign to utilize a photoelastic modulated wave plate and an Ithaco lock-in amplifier–the photoelastic modulating polarimeter. The final design in 2000 concluded with a fully remote operable device. The legacy of the polarimetric programs includes studies of close binaries, pulsating hot stars, and luminous late-type variables.

Preliminary clinical evaluation of Somatostatin Receptor Scintigraphy (SRS) with 99mTc-EDDA/HYNIC-TATE in comparison to 111In-Octreoscan and 131 I MIBG scans

International Nuclear Information System (INIS)

Hubalewska, A.; Fross, K.; Staszczak, A.; Huszno, B.; Mikolajczak, R.; Gorska, A.

2004-01-01

Full text: Over expression of somatostatin receptors in various neuroendocrine tumours prompted development of somatostatin analogues, which after radioactive labelling, could be used in oncological diagnostics. Somatostatin Receptor Positive Tumour (Spt) imaging with 111In-DTPA-DPhe1- octreotide (111In-Octreoscan) has become a widely used diagnostic procedure in clinical nuclear medicine. However 111In as a radiolabel has several drawbacks, including limited availability, sub optimal gamma energy and high radiation burden to the patient. Technetium (99mTc) labelling of somatostatin analogues is especially attractive due to the ready availability of 99mTc from generators and its well recognised favourable imaging characteristics. HYNIC conjugated Tyr 3 -Octreotate (HYNIC-TATE) prepared in our laboratory in a dry kit form was labelled with technetium-99mTc, with tricine and EDDA used as coligands. Tyr3-octreotate differs from octreotide (OC) by more hydrophilic tyrosine in the third position and the terminal threonine, which replaced threoninol present in OC. In vitro studies using cell lines transfected with somatostatin receptors (SSTR) revealed that octreotate shows 14- 17 times better binding affinity for SSTR type 2 than does OC. It is expected to clear more rapidly from non-target tissues as a result of the carboxylic group at the C-terminal of the peptide. HYNIC has been used as bifunctional chelator in 99mTc-HYNIC-Tyr3-octreotide (TOC) by Maecke and Behe, who reported on its favourable preclinical characteristics when EDDA was used as a co-ligand. These pre-clinical data were confirmed by Decristoforo and Mather and their early clinical studies appeared recently. The new radiopharmaceutical - 99mTc-DDA/HYNICTATE was evaluated in-vitro and in-vivo in an animal model and its potential for SSTR scintigraphy was documented. In the current patient study the diagnostic usefulness of the new radiopharmaceutical was tested for detection of tumours expressing SSTR

Nopcsa, Baron Franz. 2014. Traveler, Scholar, Politician, Adventurer – A Transylvanian Baron at the Birth of Albanian Independence (ed. and trans. from German Robert Elsie. Budapest: Central European University Press. 227 pp.

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David Mandler

2015-01-01

Full Text Available Nopcsa, Baron Franz. 2014. Traveler, Scholar, Politician, Adventurer – A Transylvanian Baron at the Birth of Albanian Independence (ed. and trans. from German Robert Elsie. Budapest: Central European University Press. 227 pp.  Reviewed by David Mandler, Independent Scholar

Establishment and characterization of Roberts syndrome and SC phocomelia model medaka (Oryzias latipes).

Science.gov (United States)

Morita, Akihiro; Nakahira, Kumiko; Hasegawa, Taeko; Uchida, Kaoru; Taniguchi, Yoshihito; Takeda, Shunichi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Shimada, Atsuko; Takeda, Hiroyuki; Yanagihara, Itaru

2012-06-01

Roberts syndrome and SC phocomelia (RBS/SC) are genetic autosomal recessive syndromes caused by establishment of cohesion 1 homolog 2 ( ESCO 2) mutation. RBS/SC appear to have a variety of clinical features, even with the same mutation of the ESCO2 gene. Here, we established and genetically characterized a medaka model of RBS/SC by reverse genetics. The RBS/SC model was screened from a mutant medaka library produced by the Targeting Induced Local Lesions in Genomes method. The medaka mutant carrying the homozygous mutation at R80S in the conserved region of ESCO2 exhibited clinical variety (i.e. developmental arrest with craniofacial and chromosomal abnormalities and embryonic lethality) as characterized in RBS/SC. Moreover, widespread apoptosis and downregulation of some gene expression, including notch1a, were detected in the R80S mutant. The R80S mutant is the animal model for RBS/SC and a valuable resource that provides the opportunity to extend knowledge of ESCO2. Downregulation of some gene expression in the R80S mutant is an important clue explaining non-correlation between genotype and phenotype in RBS/SC. © 2012 The Authors Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists.

ANTHROPOLOGY AT WAR: ROBERT H. LOWIE AND THE TRANSFORMATION OF THE CULTURE CONCEPT, 1904 to 1954.

Science.gov (United States)

Bargheer, Stefan

2017-03-01

The concept of culture used in American anthropology has fundamentally transformed throughout the first half of the twentieth century. The changing resonance of the work of Robert H. Lowie offers revealing insights into this development. Lowie was part of the first generation of students of Franz Boas that highlighted the importance of individual variation for the study of both primitive and civilized societies. Yet, its initial resonance notwithstanding, the culture concept that prevailed in the discipline went into a different direction as the result of anthropologists' involvement in the war effort. It was advanced by the second generation of Boas' students such as Ruth Benedict and Margaret Mead, who stressed the homogeneity of cultures. The contrast highlights the diversity of approaches available within anthropology in the first half of the century and the crucial impact of World War II in determining which of these possibilities became institutionalized in the decades after the war. © 2017 Wiley Periodicals, Inc.

Review: Local Government in England: Centralisation, Autonomy and Control by Colin Corpus, Mark Roberts, Rachel Wall

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Jonathan Carr-West

2018-04-01

Full Text Available Local Government in England: Centralisation, Autonomy and Control is a serious book and an important contribution to the scholarship around local government. It opens however, with a pleasingly comic tableau as academics from England, Portugal and Poland bicker amiably at a conference and on Twitter about whose country is really the most centralised. The rest of the book is devoted to showing why the English academics were right, why it matters and what should be done about it. The main thrust of the text is an analysis of the impact of the dominant policy narratives around centralism and localism. The argument that Copus, Wall and Roberts put forward could be boiled down to the assertion that the problem with local government in England is that it is neither local nor government. But to make this case they first helpfully unpack several sets of concepts that are all too often elided together.

Direitos fundamentais, ponderação e racionalidade jurídica nas decisões judiciais brasileiras: uma leitura a partir de Robert Alexy / Fundamental rights, balancing and legal rationality in brazilian judicial decisions: a reading from Robert Alexy

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Heletícia Leão de Oliveira

2016-02-01

Full Text Available Este artigo analisa aspectos relevantes da dogmática dos direitos fundamentais e do seu sopesamento a partir do pensamento de Robert Alexy, cuja teoria tenta responder de forma racional e fundamentada as questões axiológicas. Alega-se que a ponderação utilizada pelos tribunais brasileiros foi transformada em um princípio e está longe da fórmula alexyana original, pois ela leva à discricionariedade. Para que as decisões judiciais não sejam acusadas de serem arbitrárias e ilegítimas, é necessária a sua devida justificação. Por isto, surgem as tentativas de aperfeiçoar a consistência metodológica dessa técnica e a fixação de parâmetros que permitam um controle de argumentação.

Aplikace logistických technologií Just-in-Time a Just-in-Sequence ve společnosti Robert Bosch spol. s r.o.

OpenAIRE

ŠTEFKOVÁ, Iveta

2009-01-01

This work is mostly oriented to define theory and application of principle Just in Time ( JIT ), Just in Sequence (JIS ) and related methods in Robert Bosch Ltd.Part goals are define theoretical basis of JIT and JIS from knowledge of Czech and foreign literature and detailed analysis of particular methods. Each method is well evaluated with all its pros and cons. Further observations engaged method of Kanban, Heijunka, MRPI, MRPII, which are close related to JIT and JIS. This work precisely d...

Londoni maalipalavik / Jaan Elken

Index Scriptorium Estoniae

Elken, Jaan, 1954-

2010-01-01

Inglise kunstniku Damien Hirsti kolmest maalinäitusest. Michael Landy kuraatoriprojektist "Art Bin" South London Gallerys. Kunstnik Mark Rothkost rääkiva John Logani näidendi "Red" ("Punane") lavastusest Donmar Warehouse'is ja 2009 a. jaanuaris lõppenud Mark Rothko tööde näitusest Tate Modernis. Manchesteris sündinud mustanahalise kunstniku Chris Ofili retrospektiivist Tate Britainis. Näitusest "The Real Van Gogh" Royal Academy of Arts'is

[Regulation of behavior in the period between the world wars: Robert Musil and Kurt Lewin].

Science.gov (United States)

Innerhofer, Roland; Rothe, Katja

2010-12-01

The paper attempts to reconstruct the proto-cybernetic concept of regulation which emerged in early 20th century both in biology and psychology, and was critically reflected in literature. The basic premise is that Kurt Lewin's field-theoretical psychology played a crucial role in the development of behavioral self-regulation concepts. The goal is to show (1) that Lewin's early experiments and theories were based on the idea of a dynamic process of self-regulation determined by the actors and their personal motivation and interaction, (2) that this concept of self-regulation functioned as a camouflage for power-strategies that aimed to regulate and optimize the economic production and social reproduction processes, (3) that in Robert Musil's fragmentary, 'fringing' novel The Man without Qualities the attempt to optimize the social and economic behavior and to establish a homeostatic state proved to be a complete failure. As a notable result, this 'literary test' of behavioral self-regulation revealed the violence and imbalance of power inherent in this concept of self-regulation and its practical implementation.

Popular culture and sporting life in the rural margins of late eighteenth-century England: the world of Robert Anderson, "The Cumberland Bard".

Science.gov (United States)

Huggins, Mike

2012-01-01

This study sets out to extend and challenge existing historiography on late eighteenth century British popular culture, customary sports, class and cultural identity, focusing upon the rural geo-political borderland of England. It suggests that prevailing class-based and more London-biased studies need to be balanced with more regionalist-based work, and shows the importance of northern regional leisure variants. The textual and historical analysis draws largely on the published works of a neglected working-class dialect poet, Robert Anderson, living and working in Cumberland, arguing that he represented a strain of ''bardic regionalism,'' a variant of Katie Trumpener’s ''bardic nationalism.''

Parole et silence pour l’expression de l’éthique dans La mort est mon métier de Robert Merle

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María Badiola Dorronsoro

2015-11-01

Full Text Available Thanks to a daring and original exercise of focusing the narrative in first person, Robert Merle makes a historical Nazi the hero and narrator of his novel La mort est mon métier. Adding to this fact a careful choice of what is said and what is omitted, the author shows that the “final solution to the Jewish problem” by Hitler was not a massacre organized by some bloodthirsty or revengeful individuals, but a «hard task» accomplished by a group of de¬humanized beings for whom the honor –and morals– consisted of total dedication to blind obe¬dience to their superiors.

Temperature profile and water depth data collected from USS ROBERT G. BRADLEY using BT and XBT casts in the Red Sea and other seas from 26 September 1988 to 28 September 1988 (NODC Accession 8800288)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The accession contains data collected from USS Robert G Bradley from September 26, 1988 to September 29, 1988. The real time data of water temperature at varying...

Phenotypic variability in 49 cases of ESCO2 mutations, including novel missense and codon deletion in the acetyltransferase domain, correlates with ESCO2 expression and establishes the clinical criteria for Roberts syndrome

DEFF Research Database (Denmark)

Vega, H; Trainer, A H; Gordillo, M

2010-01-01

Roberts syndrome (RBS) and SC phocomelia are caused by mutations in ESCO2, which codes for an acetyltransferase involved in the regulation of sister chromatid cohesion. Of 26 mutations described to date, only one missense mutation has been reported and all others are predicted to be truncating...

Phenotypic variability in 49 cases of ESCO2 mutations, including novel missense and codon deletion in the acetyltransferase domain, correlates with ESCO2 expression and establishes the clinical criteria for Roberts syndrome

NARCIS (Netherlands)

Vega, H.; Trainer, A.H.; Gordillo, M.; Crosier, M.; Kayserili, H.; Skovby, F.; Uzielli, M.L.G.; Schnur, R.E.; Manouvrier, S.; Blair, E.; Hurst, J.A.; Forzano, F.; Meins, M.; Simola, K.O.J.; Raas-Rothschild, A; Hennekam, R.C.M.; Jabs, E.W.

2010-01-01

Background Roberts syndrome (RBS) and SC phocomelia are caused by mutations in ESCO2, which codes for an acetyltransferase involved in the regulation of sister chromatid cohesion. Of 26 mutations described to date, only one missense mutation has been reported and all others are predicted to be

Synthesis, Characterization, and In Vitro Evaluation of New (99m)Tc/Re(V)-Cyclized Octreotide Analogues: An Experimental and Computational Approach.

Science.gov (United States)

Li, Yawen; Ma, Lixin; Gaddam, Vikram; Gallazzi, Fabio; Hennkens, Heather M; Harmata, Michael; Lewis, Michael R; Deakyne, Carol A; Jurisson, Silvia S

2016-02-01

Radiolabeled proteolytic degradation-resistant somatostatin analogues have been of long-standing interest as cancer imaging and radiotherapy agents for targeting somatostatin receptor-positive tumors. Our interest in developing (186)Re- and (188)Re-based therapeutic radiopharmaceuticals led to investigation of a new Re(V)-cyclized octreotide analogue, Re(V)-cyclized, thiolated-DPhe(1)-Cys(2)-Tyr(3)-DTrp(4)-Lys(5)-Thr(6)-Cys(7)-Thr(OH)(8) (Re-SDPhe-TATE) using both experimental and quantum chemical methods. The metal is directly coordinated to SDPhe-TATE through cyclization of the peptide around the [ReO](3+) core. Upon complexation, four isomers were observed; the isolated/semi-isolated isomers exhibited different somatostatin receptor (sstr) binding affinities, 0.13 to 1.5 μM, in rat pancreatic tumor cells. Two-dimensional NMR experiments and electronic structure calculations were employed to elucidate the structural differences among the different isomers. According to NMR studies, the metal is coordinated to three thiolates and the backbone amide of Cys(2) in isomers 1 and 4, whereas the metal is coordinated to three thiolates and the backbone amide of Tyr(3) in isomer 2. Quantum chemical methods clarified the stereochemistry of Re-SDPhe-TATE and the possible peptide arrangements around the [ReO](3+) core. The re-cyclization reaction was translated to the (99m)Tc radiotracer level with four isomers observed on complexation with comparable HPLC retention times as the Re-SDPhe-TATE isomers. About 85% total (99m)Tc labeling yield was achieved by ligand exchange from (99m)Tc-glucoheptonate at 60 °C for an hour. About 100% and 51% of (99m)Tc(V)-cyclized SDPhe-TATE remained intact in phosphate buffered saline and 1 mM cysteine solution under physiological conditions at 6 h, respectively.

Rapid blood clearance and lack of long-term renal toxicity of 177Lu-DOTATATE enables shortening of renoprotective amino acid infusion

International Nuclear Information System (INIS)

Kashyap, Raghava; Eu, Peter; Jackson, Price; Hofman, Michael S.; Hicks, Rodney J.; Beauregard, Jean-Mathieu; Zannino, Diana

2013-01-01

The aim of the study was to investigate the feasibility of shortening the recommended 4-h renoprotective amino acid infusion in patients receiving peptide receptor chemoradionuclide therapy (PRCRT) using radiosensitizing 5-fluorouracil. We evaluated the clearance of radiopeptide from the blood, long-term nephrotoxicity in patients undergoing PRCRT with the conventional 4-h amino acid infusion and renal uptake in patients receiving an abbreviated infusion. The whole-blood clearance of 177 Lu-DOTA-octreotate (LuTate) was measured in 13 patients receiving PRCRT. A retrospective analysis of short-term and long-term changes in glomerular filtration rate (GFR) in 96 consecutive patients receiving a 4-h infusion was performed. Renal LuTate retention estimated using quantitative SPECT/CT in 22 cycles delivered with a 2.5-h amino acid infusion was compared with that in 72 cycles with the 4-h infusion. LuTate demonstrated biexponential blood clearance with an initial clearance half-time of 21 min. Approximately 88 % of blood activity was cleared within 2 h. With the 4-h protocol, there was no significant change in GFR (1.2 ml/min mean increase from baseline; 95 % CI -6.9 to 4.4 ml/min) and no grade 3 or 4 nephrotoxicity at the end of induction PRCRT. The long-term decline in GFR after a median follow up of 22 months was 2.2 ml/min per year. There was no significant difference in the renal LuTate retention measured in patients receiving a 2.5-h amino acid infusion compared to those who had a 4-h infusion. The greatest renal exposure to circulating radiopeptide occurs in the first 1 - 2 h after injection. This, combined with the safety of LuTate PRCRT, allows consideration of an abbreviated amino acid infusion, increasing patient convenience and reducing human resource allocation. (orig.)

Rapid blood clearance and lack of long-term renal toxicity of {sup 177}Lu-DOTATATE enables shortening of renoprotective amino acid infusion

Energy Technology Data Exchange (ETDEWEB)

Kashyap, Raghava; Eu, Peter [Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne (Australia); Jackson, Price [Peter MacCallum Cancer Centre, Department of Physical Sciences, Melbourne (Australia); Hofman, Michael S.; Hicks, Rodney J. [Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne (Australia); The University of Melbourne, Departments of Medicine and Radiology, Melbourne (Australia); Beauregard, Jean-Mathieu [Universite Laval, Department of Radiology, Quebec City (Canada); Zannino, Diana [Peter MacCallum Cancer Centre, Department of Biostatistics and Clinical Trials, Melbourne (Australia)

2013-12-15

The aim of the study was to investigate the feasibility of shortening the recommended 4-h renoprotective amino acid infusion in patients receiving peptide receptor chemoradionuclide therapy (PRCRT) using radiosensitizing 5-fluorouracil. We evaluated the clearance of radiopeptide from the blood, long-term nephrotoxicity in patients undergoing PRCRT with the conventional 4-h amino acid infusion and renal uptake in patients receiving an abbreviated infusion. The whole-blood clearance of {sup 177}Lu-DOTA-octreotate (LuTate) was measured in 13 patients receiving PRCRT. A retrospective analysis of short-term and long-term changes in glomerular filtration rate (GFR) in 96 consecutive patients receiving a 4-h infusion was performed. Renal LuTate retention estimated using quantitative SPECT/CT in 22 cycles delivered with a 2.5-h amino acid infusion was compared with that in 72 cycles with the 4-h infusion. LuTate demonstrated biexponential blood clearance with an initial clearance half-time of 21 min. Approximately 88 % of blood activity was cleared within 2 h. With the 4-h protocol, there was no significant change in GFR (1.2 ml/min mean increase from baseline; 95 % CI -6.9 to 4.4 ml/min) and no grade 3 or 4 nephrotoxicity at the end of induction PRCRT. The long-term decline in GFR after a median follow up of 22 months was 2.2 ml/min per year. There was no significant difference in the renal LuTate retention measured in patients receiving a 2.5-h amino acid infusion compared to those who had a 4-h infusion. The greatest renal exposure to circulating radiopeptide occurs in the first 1 - 2 h after injection. This, combined with the safety of LuTate PRCRT, allows consideration of an abbreviated amino acid infusion, increasing patient convenience and reducing human resource allocation. (orig.)

Projecting Dynastic Majesty: State Ceremony in the Reign of Robert Bruce

Directory of Open Access Journals (Sweden)

Lucinda Dean

2015-07-01

Full Text Available Following the murder of his rival John Comyn on 10 February at Greyfriars in Dumfries, and the crisis this act incited, Robert the Bruce’s inaugural ceremony took place at Scone in late March 1306. Much about this ceremony is speculative; however, subsequent retrospective legitimisation of the Bruce claims to the royal succession would suggest that all possible means by which Robert’s inauguration could emulate his Canmore predecessors and outline his right to rule on a level playing field with his contemporaries were amplified, particularly where they served the common purpose of legitimising Robert’s highly questioned hold on power. Fourteenth-century Scottish history is inextricably entwined in the Wars of Independence, civil strife and an accelerated struggle for autonomous rule and independence. The historiography of this period is unsurprisingly heavily dominated by such themes and, while this has been offset by works exploring subjects such as the tomb of Bruce and the piety of the Bruce dynasty, the ceremonial history of this era remains firmly in the shadows. This paper will address three key ceremonies through which a king would, traditionally, make powerful statements of royal authority: the inauguration or coronation of Bruce; the marriage of his infant son to the English princess Joan of the Tower in 1328, and his extravagant funeral ceremony in 1329. By focusing thus this paper hopes to shed new light on the ‘dark and drublie days’ of fourteenth-century Scotland and reveal that glory, dynastic majesty and pleasure were as central to the Scottish monarchy in this era as war and political turbulence.

The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

CERN Multimedia

Maximilien Brice

2008-01-01

The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

The dilemmas of indefiniteness: Utopia, fluidity and subjectivity in Stone, by Adam Roberts

Directory of Open Access Journals (Sweden)

André Cabral de Almeida Cardoso

2017-06-01

Full Text Available http://dx.doi.org/10.5007/2175-8026.2017v70n2p107 Ae, the narrator-protagonist of the novel Stone, by Adam Roberts, is the only criminal in a post-human utopian society in which the use of nanotechnology has allowed humanity to reach its plenitude. Isolated from the rest of society, one day Ae is offered freedom and wealth if he agrees to kill the population of a whole planet. After accepting this offer, Ae must try to fulfil his mission at the same time that he questions himself and tries to discover who his employers are. In developing the conflict between this deviant individual and the utopia in which he lives, Stone examines the limits of the utopia itself, which is based on the idea of flux and indefiniteness. The novel also explores the models of subjectivity created in the context of this utopia. The notion of utopia as a well-defined social project is replaced by the image of utopian bodies, influenced by technologies that challenge the definitions of the human and of the post-human. In establishing this network of tensions and indefiniteness, the novel offers the possibility that the marginalized sociopath might be the only one capable of examining in depth the reality of a world anesthetized by its own comfort.

Temperature profile and water depth data collected from USS ROBERT G. BRADLEY using BT and XBT casts in the NE/NW Atlantic Ocean and other seas from 03 May 1988 to 31 May 1988 (NODC Accession 8800213)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and water depth data were collected using BT and XBT casts from the USS ROBERT G. BRADLEY in the Northwest / Northeast Atlantic Ocean, Arabian...

CASTEL, Robert; et al. (2013. Individuación, Precariedad, Inseguridad: ¿desinstitucionalización del presente? Buenos Aires, Paidos. 176 pp.

Directory of Open Access Journals (Sweden)

Maximiliano E. Korstanje

2014-12-01

Full Text Available Individuación, precariedad, Inseguridad es una obra editada en cinco secciones, escritas por reconocidos sociólogos quienes se convocaron el 1 de marzo de 2011 en una conferencia organizada por la Casa Argentina en París. Robert Castel, Denis Merklen, Numa Murard y Gabriel Kessler focalizan en el tema de la vulnerabilidad ciudadana del presente, las relaciones productivas en la modernidad y el rol del riesgo en la vida social de las personas, entre los temas más importantes. Si bien a primera vista, cada argumento parece (por tratarse de diversas personas contradictorio con los restantes, lo cierto es que una lectura profunda revela todo lo contrario.

Anomia, normalidad y función del crimen desde la perspectiva de Robert Merton y su incidencia en la criminología

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Omar Huertas Díaz

2010-06-01

Full Text Available El presente artículo expone la teoría criminológica desarrollada por Robert Merton, a partir del estudio del delito en la sociedad norteamericana. Para ello, en la introducción se hace referencia a las condiciones económicas, sociales y jurídicas de la época, contextualizando la teoría de la anomia desarrollada por Merton en el marco del pensamiento estructural funcionalista; luego, se menciona la importancia de sus planteamientos, relacionándolos con formulaciones posteriores y la teoría sistémica de la prevención integradora, y por último, se dan a conocer las conclusiones.

Caracterização morfológica de frutos, sementes e germinação de Sideroxylon obtusifolium (Roem. e Schult. Penn. (Sapotaceae

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Kelina Bernardo Silva

2012-02-01

Full Text Available Estudos que visam ao conhecimento da morfologia de sementes e plântulas contribuem para a identificação das espécies, facilitando o reconhecimento das fases iniciais do seu desenvolvimento. Assim, os objetivos deste trabalho foram caracterizar morfologicamente as estruturas externa e interna dos frutos e das sementes de Sideroxylon obtusifolium (Roem. e Schult. Penn., além de descrever e ilustrar a morfologia externa da plântula. Para a descrição dos frutos foram observados detalhes externos e internos do pericarpo, referentes a textura, consistência, cor, pilosidade, brilho, forma, número de sementes por fruto e deiscência. Foram analisadas as seguintes variáveis externas das sementes: dimensões, cor, textura, consistência, forma e posição do hilo e da micrópila; e as internas: presença ou ausência de endosperma, tipo, forma, cor, posição dos cotilédones, eixo-hipocótilo-radícula e plúmula. A germinação foi considerada desde o intumescimento da semente até a emissão dos protófilos, sendo a plântula considerada estabelecida quando os protófilos já estavam totalmente expandidos. Os frutos de S. obtusifolium são dos tipos bacoide, globoso ou elipsoide, indeiscente e monospérmico. As sementes variam de globosas a elipsoides, e o embrião é do tipo cotiledonar e ocupa posição basal na semente. A germinação tem início no décimo segundo dia e pode ser encerrada no vigésimo primeiro dia após a semeadura.

Robert Castel, Gabriel Kessler, Denis Merklen, Numa Murard (2013: Individuación, Precariedad, Inseguridad: ¿desinstitucionalización del Presente? Buenos Aires, Paidós

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Maximiliano E. Korstanje

2014-09-01

Full Text Available Un libro editado en cinco secciones, cada una de ellas escritas por reconocidos sociólogos quienes se convocaron el 01 de Marzo de 2011 en una conferencia organizada por la Casa Argentina en París. Robert Castel, Denis Merklen, Numa Murard y Gabriel Kessler focalizan en el tema de la vulnerabilidad ciudadana del presente, las relaciones productivas en la modernidad y el rol del riesgo en la vida social de las personas entre los temas más importantes.

Robert Plant (1818–1858: A Victorian plant hunter in Natal, Zululand, Mauritius and the Seychelles

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Donal P. McCracken

2011-03-01

Full Text Available In the 1850s Robert William Plant collected plants and other natural specimens in what is now KwaZulu-Natal. This one-time Englishman compiled a dictionary for gardeners before emigrating to Natal in 1850. There he worked as the agent for Samuel Stevens, the London dealer in ‘curiosities of natural history’. Though Plant collected mainly plants, he also sent consignments of beetles, butterflies, bird skins and shells back to Britain. He published the first scientific paper on Zululand and was requested by the Royal Botanic Gardens at Kew to write the first Flora natalensis. It was while collecting for this never-to-be-completed treatise that Plant contracted malaria in Maputaland. He died in St Lucia in 1858 and in doing so became South Africa’s martyr to botany. What emerges from this study is a picture of the difficulties faced by plant hunters in mid-19th-century South Africa, the sort of plants they collected and the necessity for them sometimes to diversify into other natural history products to survive.

Turning point: the Robert Wood Johnson Foundation's effort to revitalize public health at the state level.

Science.gov (United States)

Hassmiller, Susan

2002-01-01

The Robert Wood Johnson (RWJ) Foundation initiated Turning Point in collaboration with the W.K. Kellogg Foundation (Kellogg) in 1997. The purpose of this major national initiative was to strengthen the public health infrastructure in the United States so that states, local communities, and their public health agencies might respond to the challenge to protect and improve the public's health in the 21st century. RWJ funded 21 states and Kellogg funded 43 communities to work together to create a new way of thinking about how health could be improved and who should be involved. Although the ultimate outcome was to improve health, both foundations expected diverse partnerships to work together to create strategic health improvement plans at both the community and state levels. The foundations funded a variety of strategies within those health improvement plans during an implementation phase. The premise in funding partnerships, as opposed to a single entity, was that effective public health systems would be developed best through a shared responsibility (including the private sector) for the health of a community.

Molecular, ultrastructural, and biological characterization of Pennsylvania isolates of Plum pox virus.

Science.gov (United States)

Schneider, William L; Damsteegt, Vernon D; Gildow, Fred E; Stone, Andrew L; Sherman, Diana J; Levy, Laurene E; Mavrodieva, Vessela; Richwine, Nancy; Welliver, Ruth; Luster, Douglas G

2011-05-01

Plum pox virus (PPV) was identified in Pennsylvania in 1999. The outbreak was limited to a four-county region in southern Pennsylvania. Initial serological and molecular characterization indicated that the isolates in Pennsylvania belong to the D strain of PPV. The Pennsylvania isolates were characterized by sequence analysis, electron microscopy, host range, and vector transmission to determine how these isolates related to their previously studied European counterparts. Genetically, Pennsylvania (PPV-Penn) isolates were more closely related to each other than to any other PPV-D strains, and isolates from the United States, Canada, and Chile were more closely related to each other than to European isolates. The PPV-Penn isolates exist as two clades, suggesting the possibility of multiple introductions. Electron microscopy analysis of PPV-Penn isolates, including cytopathological studies, indicated that the virions were similar to other Potyvirus spp. PPV-Penn isolates had a herbaceous host range similar to that of European D isolates. There were distinct differences in the transmission efficiencies of the two PPV-Penn isolates using Myzus persicae and Aphis spiraecola as vectors; however, both PPV-Penn isolates were transmitted by M. persicae more efficiently than a European D isolate but less efficiently than a European M isolate.

Initial evaluation of the Robert Wood Johnson Foundation Nurse Faculty Scholars program.

Science.gov (United States)

Hickey, Kathleen T; Hodges, Eric A; Thomas, Tami L; Coffman, Maren J; Taylor-Piliae, Ruth E; Johnson-Mallard, Versie M; Goodman, Janice H; Jones, Randy A; Kuntz, Sandra; Galik, Elizabeth; Gates, Michael G; Casida, Jesus M

2014-01-01

The Robert Wood Johnson Foundation Nurse Faculty Scholars (RWJF NFS) program was developed to enhance the career trajectory of young nursing faculty and to train the next generation of nurse scholars. Although there are publications that describe the RWJF NFS, no evaluative reports have been published. The purpose of this study was to evaluate the first three cohorts (n = 42 scholars) of the RWJF NFS program. A descriptive research design was used. Data were derived from quarterly and annual reports, and a questionnaire (seven open-ended questions) was administered via Survey Monkey Inc. (Palo Alto, CA, USA). During their tenure, scholars had on average six to seven articles published, were teaching/mentoring at the graduate level (93%), and holding leadership positions at their academic institutions (100%). Eleven scholars (26%) achieved fellowship in the American Academy of Nursing, one of the highest nursing honors. The average ratings on a Likert scale of 1 (not at all supportive) to 10 (extremely supportive) of whether or not RWJF had helped scholars achieve their goals in teaching, service, research, and leadership were 7.7, 8.0, 9.4, and 9.5, respectively. The majority of scholars reported a positive, supportive relationship with their primary nursing and research mentors; although, several scholars noted challenges in connecting for meetings or telephone calls with their national nursing mentors. These initial results of the RWJF NFS program highlight the success of the program in meeting its overall goal-preparing the next generation of nursing academic scholars for leadership in the profession. Copyright © 2014 Elsevier Inc. All rights reserved.

Unauthorised Biographies: An Analysis Under the Perspective of Robert Alexy's External Theory

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Adriana Inomata

2015-12-01

Full Text Available The present paperwork aimed to analyse whether or not the publication of a biography should require the prior authorisation from the subject  or their family. As there is, in this case, a collision between personality rights and freedom of speech, the proportionality test was used to solve such conflict. The first step was to define biography as a non-ficctional genre. The paperwork then aimed to define the theory of the principles, the external theory of the restriction of fundamental rights and the proportionality test developed by jurist Robert Alexy, which are largely used in Brazil by authors like Virgílio Afonso da Silva, Ingo Wolfgang Sarlet and Daniel Sarmento. It was observed that when fundamental rights collide, the proportionality must be verified and as a result there is a conditional precedence relation between the rights. In such case, the ceding right will be restricted by the preciding one. The external theory is a recognised manner of verifying whether the restriction of a fundamental right is legit or if it is a violation. The need for prior authorisation, based on the personality protection, restricts freedom of speech, on the other hand, its exemption is based on the right to freedom of speech. By applying the aforementioned method, a particular rule was developed and the conditions for it to be applicable: freedom of speech prevails over personality rights in given conditions (public figure, over suitable means, no expectation for privacy in the publication, diligence in the verification of truth or social and journalistic interest over the information

Conference "Internet, Web, What's next?" on 26 June 1998 at CERN : Robert Verrue, Director general of the DGXIII of the European Commission, responsible for telecommunication in Europe, outlines the Commission's vision on the Information Society in Europe

CERN Multimedia

1998-01-01

Conference "Internet, Web, What's next?" on 26 June 1998 at CERN : Robert Verrue, Director general of the DGXIII of the European Commission, responsible for telecommunication in Europe, outlines the Commission's vision on the Information Society in Europe

Obituary: Robert C. Bless (1927 - 2015)

Science.gov (United States)

Surrounded by his loving family, Robert Charles Bless died at home on November 29th, three days before his 88th birthday. He was born in Ithaca, NY on Dec. 3, 1927 to a Russian father, Arthur Aaron Bless, and a French mother, Eva Chantrell Bless. Bob spent many summers on the family farm in the South of France, where he gained a great pride and joy in his French heritage, large extended family, and mother tongue. As a child growing up in Gainesville, FL, Bob's first job was snake wrangling, earning 10 cents per foot, with an added bonus for the more venomous species. Young Robbie took daily adventures in the Florida woods and swamps, armed only with pockets full of pecans and oranges. He enjoyed spending time at the family's lake cabin, where he learned to sail and helped his father plant acres of trees to grow their timber plantation. As a first generation immigrant, Bob's father received a PhD in physics, which inspired Bob to pursue an extensive educational route in astrophysics. Bob excelled in academics, graduating high school at the age of 16 and the University of Florida (B.Sc.) at 19. His path to graduate school was interrupted by a diagnosis of tuberculosis that forced him into a Florida sanitorium for one year. During this time, Bob made the most of what he described as the most dismal part of life by advocating for patient rights, initiating an inter-sanitorium newsletter, and gaining skills and experience in community organization and leadership - qualities that would later inform his leadership in academe. After being one of the first successfully treated tuberculosis patients in the US, Bob went on to earn a M.Sc. from Cornell University, and received his PhD degree in Astronomy from the University of Michigan in 1958. That same year, Bob joined the staff of the Astronomy Department of the University of Wisconsin (UW), Madison. It was there that Bob met Diane McQueen. Despite Bob's Dodge Dart and what has been described as the worst first date in

Features phenomenon of «mental revolution» in research Robert Mandrou

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E. N. Bashkeyeva

2015-04-01

Full Text Available The author analyzes the views on the problem of «mental revolution» Robert Mandrou, the second generation of the school of «Annals». Mandrou contribution to the study of the phenomenon of mentalities, and in particular the phenomenon of «mental» revolution is enormous. Thanks to him, the new French historiography changed its name to the historical psychology at the history of mentalities, and in interdisciplinary humanities studies of the Soviet period began to develop themes mentality. R. Mandrou explores quiet «mental revolution» XVII century. We are talking about a change of attitude to the problem of witchcraft at all the French intellectuals, among them ­ parliamentarians, representatives of experimental science, especially medicine. Reconstruction of the revolutionary mental changes in France early modern era carried out in three dimensions ­ human, social environment and activities. Basic mental strategy early modern humans ­ recourse to the all­powerful deity in whose hands is the fate of all people and things. Each social class, professional and religious groups were carriers of its characteristic mental outlook, which is composed of knowledge about nature and man, beliefs, stereotypes, prejudice resulting from education in the family and society, etc. There is a dialectical relationship between the structures of the slow evolution of the (customs and conjuncture, that is giving way to forms of psychological climate in which the developing crises, mature big problem, expressing the evolution of mentalities large extent. Area of mental conjuncture ­ an area of avant­garde, the most susceptible to updates of the society, especially business people, intellectuals, artisans. Mental conjuncture like economic, they differ in duration. Оbviously that in determining the mental climate must be treated and to the material conjuncture: hunger or a good harvest, lack of money or their abundance, health epidemics or relative order.

Frank Robert Tangherlini — the Founder of an Alternative Relativistic Kinematics (On the Occasion of His 85th Birthday

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Malykin G. B.

2009-01-01

Full Text Available Already fifty years ago, Frank Robert Tangherlini, an American theoretical physicist, suggested an original procedure which, targeting the synchronization of clocks located in two different inertial reference frames of the space, was di erent from that Einstein had introduced. As a result of these, Tangherlini had deduced the so-called the Tangher- lini transformations, which are a sort of the transformations of the spatial coordinates and time being moved from one inertial reference frame into another one. The Tangher- lini transformations differ from the Lorentz transformations (which can be meant clas- sic ones in the theory of relativity and, in particular, suggest the velocity of light to be anisotropic in a moving inertial reference frame. The Tangherlini transformations be- ing applied provide adequate explanations to all well-known interference experiments checking of the Special Theory of Relativity.

Algebraic number theory

CERN Document Server

Weiss, Edwin

1998-01-01

Careful organization and clear, detailed proofs characterize this methodical, self-contained exposition of basic results of classical algebraic number theory from a relatively modem point of view. This volume presents most of the number-theoretic prerequisites for a study of either class field theory (as formulated by Artin and Tate) or the contemporary treatment of analytical questions (as found, for example, in Tate's thesis).Although concerned exclusively with algebraic number fields, this treatment features axiomatic formulations with a considerable range of applications. Modem abstract te

Some Remarks on the Translation of Proper Names in Mark of Toledo’s and Robert of Ketton’s Latin Qur’ā Translations

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Cecini, Ulisse

2014-12-01

Full Text Available This article presents Robert of Ketton’s (1143 and Mark of Toledo’s (1210 Latin translations of proper names appearing in the Qur’ān. Proper names represent a particular sub-group of words that challenges the translator in his task as a mediator between two cultures. Proper names are in fact tied to the person or the entity to which they belong and cannot, in absolute terms, be translated without losing their characteristic of being “proper.” In the article, the names are divided in different categories and the different methods are explained, that each translator uses to render the names in the translation. Final remarks try to formulate some hypotheses in order to explain the different choices of each translator in the context of their respective Qur’ān translation.En este artículo se presentan las traducciones latinas que Robert de Ketton (1143 y Marcos de Toledo (1210 hicieron de los nombres propios que aparecen en el Corán. Los nombres propios son un grupo particular de palabras que ponen a prueba al traductor en su tarea como mediador entre dos culturas. En efecto, los nombres propios son naturalmente vinculados a la persona o la entidad a las que pertenecen y no pueden ser traducidos sin perder su característica de ser «propios». En el artículo los nombres se dividen en diferentes categorías y se exponen de forma detallada los diferentes métodos que cada traductor utiliza para expresar los nombres en Latín. En las observaciones finales se formulan algunas hipótesis para explicar las diferentes soluciones que cada traductor ha elegido en el contexto de su propia traducción del Corán.

77 FR 26522 - Inland Waterways Users Board

Science.gov (United States)

2012-05-04

...: June 6, 2012. Location: The OMNI William Penn Hotel, 530 William Penn Place, Pittsburgh, PA 15219 at... budget, an update of the Inland Marine Transportation System (IMTS) Capital Projects Business Model...

No Bursts Detected from FRB121102 in Two 5 hr Observing Campaigns with the Robert C. Byrd Green Bank Telescope

Science.gov (United States)

Price, Danny C.; Gajjar, Vishal; Rosenthal, Lee; Hallinan, Gregg; Croft, Steve; DeBoer, David; Hellbourg, Greg; Isaacson, Howard; Lebofsky, Matt; Lynch, Ryan; MacMahon, David H. E.; Men, Yunpeng; Xu, Yonghua; Liu, Zhiyong; Lee, Kejia; Siemion, Andrew

2018-02-01

Here, we report non-detection of radio bursts from Fast Radio Burst FRB 121102 during two 5-hour observation sessions on the Robert C. Byrd 100-m Green Bank Telescope in West Virginia, USA, on December 11, 2017, and January 12, 2018. In addition, we report non-detection during an abutting 10-hour observation with the Kunming 40-m telescope in China, which commenced UTC 10:00 January 12, 2018. These are among the longest published contiguous observations of FRB 121102, and support the notion that FRB 121102 bursts are episodic. These observations were part of a simultaneous optical and radio monitoring campaign with the the Caltech HIgh- speed Multi-color CamERA (CHIMERA) instrument on the Hale 5.1-m telescope.

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside

International Nuclear Information System (INIS)

Lewin, Jeremy; Rao, Aparna; Mileshkin, Linda; Cullinane, Carleen; Akhurst, Tim; Eu, Peter; Waldeck, Kelly; Watkins, D.N.; Hicks, Rodney J.

2015-01-01

Small cell cancers (SmCC), whether pulmonary (SCLC) or extrapulmonary, have a poor prognosis unless localised at diagnosis. Given a proportion of these cancers express somatostatin receptor subtype 2 (SSTR2), we aimed to investigate the efficacy of targeted peptide receptor chemoradionuclide therapy (PRCRT). In this preclinical study, we used a SCLC xenograft mouse model with high expression of SSTR2 to investigate the effect of peptide receptor radionuclide therapy (PRRT) with chemotherapy compared to either alone. We subsequently explored the clinical utility in a patient with SmCC with high SSTR expression treated with PRCRT. Robust expression of SSTR2 in NCI-H69 SCLC xenografts was documented by 68 Ga-DOTA-octreotate (GaTate) (tumour to background uptake ratio = 35). The combination of PRRT using 177 Lu-DOTA-octreotate (LuTate) with carboplatin/etoposide (C/E) chemotherapy was more effective than either LuTate or C/E alone for regression of the NCI-H69 model (p value < 0.05). PRCRT was associated with significantly prolonged survival versus PRRT (p value = 0.0001) or chemotherapy alone (p value = 0.0058). In the subsequent case study, a patient with relapsed SmCC with high SSTR2 expression on GaTate PET underwent PRCRT with radiosensitising etoposide with evidence of a complete metabolic response for 4 months. Given the limited treatment options in this setting, PRCRT is a promising therapeutic option for SSTR2-expressing SmCC. (orig.)

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside

Energy Technology Data Exchange (ETDEWEB)

Lewin, Jeremy; Rao, Aparna; Mileshkin, Linda [Division of Hematology and Medical Oncology, East Melbourne, VIC (Australia); Cullinane, Carleen [Division of Cancer Research, East Melbourne, VIC (Australia); The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC (Australia); Akhurst, Tim; Eu, Peter [Centre for Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Waldeck, Kelly [Division of Cancer Research, East Melbourne, VIC (Australia); Watkins, D.N. [Monash University, Monash Institute of Medical Research, Clayton, VIC (Australia); Hicks, Rodney J. [Centre for Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC (Australia)

2015-01-15

Small cell cancers (SmCC), whether pulmonary (SCLC) or extrapulmonary, have a poor prognosis unless localised at diagnosis. Given a proportion of these cancers express somatostatin receptor subtype 2 (SSTR2), we aimed to investigate the efficacy of targeted peptide receptor chemoradionuclide therapy (PRCRT). In this preclinical study, we used a SCLC xenograft mouse model with high expression of SSTR2 to investigate the effect of peptide receptor radionuclide therapy (PRRT) with chemotherapy compared to either alone. We subsequently explored the clinical utility in a patient with SmCC with high SSTR expression treated with PRCRT. Robust expression of SSTR2 in NCI-H69 SCLC xenografts was documented by {sup 68}Ga-DOTA-octreotate (GaTate) (tumour to background uptake ratio = 35). The combination of PRRT using {sup 177}Lu-DOTA-octreotate (LuTate) with carboplatin/etoposide (C/E) chemotherapy was more effective than either LuTate or C/E alone for regression of the NCI-H69 model (p value < 0.05). PRCRT was associated with significantly prolonged survival versus PRRT (p value = 0.0001) or chemotherapy alone (p value = 0.0058). In the subsequent case study, a patient with relapsed SmCC with high SSTR2 expression on GaTate PET underwent PRCRT with radiosensitising etoposide with evidence of a complete metabolic response for 4 months. Given the limited treatment options in this setting, PRCRT is a promising therapeutic option for SSTR2-expressing SmCC. (orig.)

An analysis of the writings of Janet Geister and Mary Roberts regarding the problems of private duty nursing.

Science.gov (United States)

Baas, L S

1992-01-01

Fifty years ago there were two widely circulated nursing journals, each with a unique purpose and style. The Trained Nurse and Hospital Review was the privately owned older journal, and the American Journal of Nursing was the voice of the professional organization. Each journal was edited by a strong nursing leader, Janet Geister and Mary Roberts, respectively. Each editor had many years of service to the nursing profession in varied capacities. Naturally, each had distinctly different interests, visions, and styles of communication. These editors witnessed and commented on the change in the sphere of nursing practice from a private duty and public health orientation to one that eventually became dominated by the hospital. Although their approaches differed, both recognized the need for organization, versatility, and creative problem solving. However, the legacy of these leaders must be considered in view of the gap that continues to exist between practicing nurses and the American Nurses' Association leadership.