Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

International Nuclear Information System (INIS)

Hoppe, M.

1996-05-01

On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D 2 or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester's Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks

Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

Energy Technology Data Exchange (ETDEWEB)

Hoppe, M. [ed.

1996-05-01

On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ``Onsite Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D{sub 2} or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester`s Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks.

Targeted Technology Transfer to US Independents

Energy Technology Data Exchange (ETDEWEB)

Donald F. Duttlinger; E. Lance Cole

2006-09-29

The Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers in 1994 as a national not-for-profit organization to address the increasingly urgent need to improve the technology-transfer process in the U.S. upstream petroleum industry. Coordinated from a Headquarters (HQ) office in Houston, PTTC maintains an active grassroots program executed by 10 Regional Lead Organizations (RLOs) and two satellite offices (Figure 1). Regional Directors interact with domestic oil and gas producers through technology workshops, resource centers, websites, newsletters, technical publications and cooperative outreach efforts. HQ facilitates inter-regional technology transfer and implements a comprehensive communications program. Active volunteers on the National Board and in Producer Advisory Groups (PAGs) in each of the 10 regions focus effort in areas that will create the most impact for domestic producers. Focused effort by dedicated individuals across the country has enabled PTTC to achieve the milestones outlined in Appendix A.

Near-term technology policies for long-term climate targets--economy wide versus technology specific approaches

International Nuclear Information System (INIS)

Sanden, B.A.; Azar, Christian

2005-01-01

The aim of this paper is to offer suggestions when it comes to near-term technology policies for long-term climate targets based on some insights into the nature of technical change. We make a distinction between economy wide and technology specific policy instruments and put forward two key hypotheses: (i) Near-term carbon targets such as the Kyoto protocol can be met by economy wide price instruments (carbon taxes, or a cap-and-trade system) changing the technologies we pick from the shelf (higher energy efficiency in cars, buildings and industry, wind, biomass for heat and electricity, natural gas instead of coal, solar thermal, etc.). (ii) Technology specific policies are needed to bring new technologies to the shelf. Without these new technologies, stricter emission reduction targets may be considered impossible to meet by the government, industry and the general public, and therefore not adopted. The policies required to bring these more advanced technologies to the shelf are more complex and include increased public research and development, demonstration, niche market creation, support for networks within the new industries, standard settings and infrastructure policies (e.g., when it comes to hydrogen distribution). There is a risk that the society in its quest for cost-efficiency in meeting near-term emissions targets, becomes blindfolded when it comes to the more difficult, but equally important issue of bringing more advanced technologies to the shelf. The paper presents mechanisms that cause technology look in, how these very mechanisms can be used to get out of the current 'carbon lock-in' and the risk with premature lock-ins into new technologies that do not deliver what they currently promise. We then review certain climate policy proposals with regards to their expected technology impact, and finally we present a let-a-hundred-flowers-bloom strategy for the next couple of decades

Integrating Technology, Art, and Writing to Create Comic Books

Science.gov (United States)

Vega, Edwin S.; Schnakenberg, Heidi L.

2006-01-01

In this article, the authors talk about the Summer Safari program that is designed for 9-to 14-year-old students. It targets individuals with an interest in comic books and a penchant for writing stories and/or drawing. The highlight of this multidisciplinary workshop is the seamless integration of writing, fine arts, and computer technology to…

The Tools of Teacher Education: Preservice Teachers' Use of Technology To Create Instructional Materials.

Science.gov (United States)

Roberts, Sherron Killingsworth; Hsu, Ying-Shao

2000-01-01

Examines the effectiveness/efficiency of preservice teachers' use of technology to create instructional materials developed in an undergraduate reading/language arts course. Results showed no significant difference between measures of overall quality of the technology assistance as compared to handmade prompts. Eighty-five percent of the teachers…

The Alternative Way of Creating Infographics Using SVG Technology

Directory of Open Access Journals (Sweden)

Sandra Pavazza

2012-07-01

Full Text Available The article develops new ways of creating and using interactive SVG infographics. The emphasis lies on the compatibility of SVG standard with other web standards, like XML, XSL, CSS, SMIL and ECMAScript, the advantages that it brings are particularly explored. There is a XSLT template developed which transforms XML data into SVG infographic, and the way of achieving complete control over data and data visualization is tested. This enabled the achieving of dynamic control of content and its presentation, and contributed to the results in reduced developing cost and time, better flexibility and reliability of the organizational system. The paper also studied the possibility to convey infographic message by adding interactivity, and explored technologies by means of which this can be achieved. The aspects of establishing a more efficient communication with end users, such as searchability and accessibility are also considered. SVG infographics are compared with other approaches for creating infographics in raster and vector techniques.

Report on a survey in fiscal 1999. Supplementary survey on research and development of carbon dioxide fixation and effective utilization technologies utilizing bacteria and algae (the survey on feasibility of bio-technologies to create economic effects, such as the biological CO2 fixation technology); 1999 nendo saikin sorui nado riyo nisanka tanso koteika yuko riyo gijutsu kenkyu kaihatsu futai chosa. Keizaiteki koka wo soshutsusuru seibutsuteki CO{sub 2} koteigijutsu nado no biotechnology no kanosei chosa

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

Bio-technologies including the biological CO2 fixation technology, or the green bio-technologies (GBT) are the technologies indispensable in realizing the change to a resource circulating and environment harmonizing society that accompanies economical growth, or in other words, the 'sustainable development'. In quantifying the feasibility of these technologies, the GBTs that contribute to creating Japan's international competitive power and employment were specified, and an approach to establish the realization target in 2010 was adopted, upon identifying the general condition of the related markets inside and outside the country. The GBT is the technology that makes the best use of Japan's independent strength created by combining the enzyme engineering and fermentation engineering with the 'genome science' (HEART). The targets are to substitute four million kiloliters of petroleum with a resource circulation type energy generated by the bio-technology; apply the bio-technology to about 30% of products and processes produced or used in Japan's chemical industries; and aim at creating markets by using environmental measurement and analysis, treatment of hard-to-decompose substances, and supports on tree planting as the three pillars. A simulation on return on investment in GBT business suggests the effect of promoting PFI. (NEDO)

The role of strategic alliances in creating technology legitimacy: a study on the emerging field of bio-plastics

NARCIS (Netherlands)

Kishna, M.J.; Niesten, E.M.M.I.; Negro, S.O.; Hekkert, M.P.

2015-01-01

The aim of this study is to analyze the role of strategic alliances in creating legitimacy for an emerging sustainable technology. The literature has identified different ways in which alliances create legitimacy for firms, but it has failed to address the legitimacy of technologies. This paper

Interaction Design Beyond the Product : Creating Technology-Enhanced Activity Spaces

DEFF Research Database (Denmark)

Kaptelinin, Victor; Bannon, Liam J.

2012-01-01

The field of interaction design to date has been predominantly concerned with designing products, that is, devices, systems, and more recently services. A growing body of theoretical and empirical analyses suggests that the scope of interaction design needs to be expanded: An explicit concern...... of the field should include not only helping designers create better products but also helping people themselves create better environments for their work, learning, and leisure activities. In this article we argue that expanding the scope of interaction design beyond products requires a revision of some...... of the most central concepts in interaction design, including the notion of “the object of design” and our understanding of the impact of technologies on human practices. The aim of the article is to explore some of these conceptual challenges and discuss possible ways of dealing with them. We differentiate...

Leveraging 21st Century Learning & Technology to Create Caring Diverse Classroom Cultures

Science.gov (United States)

Tarbutton, Tanya

2018-01-01

Creating diverse caring classroom environments, for all students, using innovative technology, is the impetus of this article. Administrators and teachers in many states have worked to integrate 21st Century Learning Outcomes and Local Control and Accountability Plans (LCAP) into daily teaching and learning. These initiatives are designed to…

Gas target with thin wall

International Nuclear Information System (INIS)

Korenchenko, A.S.; Korenchenko, S.M.; Kravchuk, N.P.; Filippov, A.I.; Fursov, A.P.

1992-01-01

The technology of targets manufacture with thin wall diameter 100 mm and lengthwise 700 mm from composition kevlar + epoxy resin is described. The test's results on pressure and vacuum are reported. The created targets are supposed to be used on the installation ARES for an investigation of muons and pions interactions with light nuclei and rare pions decay 'on flying'. 5 refs.; 2 figs.; 2 tabs

Multicultural Media Authorship: Using Technology to Create Children's Literature Texts

Science.gov (United States)

Byker, Erik Jon; Good, Amy J.; Miller, Erin; Kissel, Brian

2018-01-01

The purpose of this article is to describe and report on how a group of teacher candidates used technology to create multicultural texts which integrated literacy and social studies. To meet this purpose, the authors briefly describe the objectives of the assignment, examine 41 teacher candidates' perceptions of the assignment, and discuss media…

Using virtual reality technology and hand tracking technology to create software for training surgical skills in 3D game

Science.gov (United States)

Zakirova, A. A.; Ganiev, B. A.; Mullin, R. I.

2015-11-01

The lack of visible and approachable ways of training surgical skills is one of the main problems in medical education. Existing simulation training devices are not designed to teach students, and are not available due to the high cost of the equipment. Using modern technologies such as virtual reality and hands movements fixation technology we want to create innovative method of learning the technics of conducting operations in 3D game format, which can make education process interesting and effective. Creating of 3D format virtual simulator will allow to solve several conceptual problems at once: opportunity of practical skills improvement unlimited by the time without the risk for patient, high realism of environment in operational and anatomic body structures, using of game mechanics for information perception relief and memorization of methods acceleration, accessibility of this program.

Gene transfer technology and genetic radioisotope targeting therapy

International Nuclear Information System (INIS)

Wang Jiaqiong; Wang Zizheng

2004-01-01

With deeper cognition about mechanisms of disease at the cellular and molecular level, gene therapy has become one of the most important research fields in medical molecular biology at present. Gene transfer technology plays an important role during the course of gene therapy, and further improvement should be made about vectors carrying target gene sequences. Also, gene survey is needed during gene therapy, and gene imaging is the most effective method. The combination of gene therapy and targeted radiotherapy, that is, 'Genetic Radioisotope Targeting Therapy', will be a novel approach to tumor gene therapy

Screening Technologies for Target Identification in Pancreatic Cancer

Energy Technology Data Exchange (ETDEWEB)

Michl, Patrick, E-mail: michlp@med.uni-marburg.de; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte [Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University Marburg, Baldinger Strasse, D-35043 Marburg (Germany)

2010-12-29

Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments.

Screening Technologies for Target Identification in Pancreatic Cancer

International Nuclear Information System (INIS)

Michl, Patrick; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte

2010-01-01

Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments

Technology Strategy for 'Environmental Technology for the Future'; Technology Target Areas; TTA1 - environmental technology for the future

Energy Technology Data Exchange (ETDEWEB)

2007-07-01

and technology based on in-depth knowledge of environmental impact will further strengthen the position of the Norwegian oil and gas industry. The industry should continue to provide proactive input to the process of creating new legislation. Continuous innovation and development are important for attracting international companies to Norway, maintaining recruitment to the industry and to support export of environmental technology that can have a positive global impact. Environmental considerations specific to the other Technology Target Areas are discussed in their respective strategies. The identified interfaces are listed in Section 7. (Author)

A Plane Target Detection Algorithm in Remote Sensing Images based on Deep Learning Network Technology

Science.gov (United States)

Shuxin, Li; Zhilong, Zhang; Biao, Li

2018-01-01

Plane is an important target category in remote sensing targets and it is of great value to detect the plane targets automatically. As remote imaging technology developing continuously, the resolution of the remote sensing image has been very high and we can get more detailed information for detecting the remote sensing targets automatically. Deep learning network technology is the most advanced technology in image target detection and recognition, which provided great performance improvement in the field of target detection and recognition in the everyday scenes. We combined the technology with the application in the remote sensing target detection and proposed an algorithm with end to end deep network, which can learn from the remote sensing images to detect the targets in the new images automatically and robustly. Our experiments shows that the algorithm can capture the feature information of the plane target and has better performance in target detection with the old methods.

Technologies using accelerator-driven targets under development at BNL

International Nuclear Information System (INIS)

Van Tuyle, G.J.

1994-01-01

Recent development work conducted at Brookhaven National Laboratory on technologies which use particle accelerator-driven targets is summarized. These efforts include development of the Spallation-Induced Lithium Conversion (SILC) Target for the Accelerator Production of Tritium (APT), the Accelerator-Driven Assembly for Plutonium Transformation (ADAPT) Target for the Accelerator-Based Conversion (ABC) of excess weapons plutonium. The PHOENIX Concept for the accelerator-driven transmutation of minor actinides and fission products from the waste stream of commercial nuclear power plants, and other potential applications

Physics and technology of inertial fusion energy targets chambers and drivers. Proceedings of a technical meeting

International Nuclear Information System (INIS)

2005-09-01

The third IAEA Technical Meeting on Physics and Technology of Inertial Fusion Energy Targets and Chambers took place 11-13 October 2004 in the Yousung Hotel Daejon, Republic of Korea. The first meeting was held in Madrid, Spain, 7-9 June 2000, and the second one in San Diego, California, 17-19 June 2002. Nuclear fusion has the promise of becoming an abundant energy source with good environmental compatibility. Excellent progress has been made in controlled nuclear fusion research on both magnetic and inertial approaches for plasma confinement. The IAEA plays a pro-active role to catalyze innovation and enhance worldwide commitment to fusion. This is done by creating awareness of the different concepts of magnetic as well as inertial confinement. The International Fusion Research Council (IFRC) supports the IAEA in the development of strategies to enhance fusion research in Member States. As part of the recommendations, a technical meeting on the physics and technology of inertial fusion energy (IFE) was proposed in one of the council meetings. The objective of the technical meeting was to contribute to advancing the understanding of targets and chambers for all proposed inertial fusion energy power plant designs. The topics to be covered were: Target design and physics, chamber design and physics, target fabrication injection and Tritium handling, assessment of safety, environment and economy aspect of IFE. It was recognized by the International Advisory Committee that the scope of the meeting should also include fusion drivers. The presentations of the meeting included target and chamber physics and technology for all proposed IFE plant concepts (laser driven, heavy-ion driven, Z-pinches, etc.). The final Research Coordination Meeting of the Coordinated Research Project on Elements of Power Plant Design for Inertial Fusion Energy, including further new results and achievements, followed the technical meeting. Twenty-nine participants from 12 countries participated

Target and (Astro-)WISE technologies Data federations and its applications

Science.gov (United States)

Valentijn, E. A.; Begeman, K.; Belikov, A.; Boxhoorn, D. R.; Brinchmann, J.; McFarland, J.; Holties, H.; Kuijken, K. H.; Kleijn, G. Verdoes; Vriend, W.-J.; Williams, O. R.; Roerdink, J. B. T. M.; Schomaker, L. R. B.; Swertz, M. A.; Tsyganov, A.; van Dijk, G. J. W.

2017-06-01

After its first implementation in 2003 the Astro-WISE technology has been rolled out in several European countries and is used for the production of the KiDS survey data. In the multi-disciplinary Target initiative this technology, nicknamed WISE technology, has been further applied to a large number of projects. Here, we highlight the data handling of other astronomical applications, such as VLT-MUSE and LOFAR, together with some non-astronomical applications such as the medical projects Lifelines and GLIMPS; the MONK handwritten text recognition system; and business applications, by amongst others, the Target Holding. We describe some of the most important lessons learned and describe the application of the data-centric WISE type of approach to the Science Ground Segment of the Euclid satellite.

Gold-manganese nanoparticles for targeted diagnostic and imaging

Energy Technology Data Exchange (ETDEWEB)

Murph, Simona Hunyadi [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-11-10

Imagine the possibility of non-invasive, non-radiation based Magnetic resonance imaging (MRI) in combating cardiac disease. Researchers at the Savannah River National Laboratory (SRNL) are developing a process that would use nanotechnology in a novel, targeted approach that would allow MRIs to be more descriptive and brighter, and to target specific organs. Researchers at SRNL have discovered a way to use multifunctional metallic gold-manganese nanoparticles to create a unique, targeted positive contrast agent. SRNL Senior Scientist Dr. Simona Hunyadi Murph says she first thought of using the nanoparticles for cardiac disease applications after learning that people who survive an infarct exhibit up to 15 times higher rate of developing chronic heart failure, arrhythmias and/or sudden death compared to the general population. Without question, nanotechnology will revolutionize the future of technology. The development of functional nanomaterials with multi-detection modalities opens up new avenues for creating multi-purpose technologies for biomedical applications.

The Advanced Linked Extended Reconnaissance & Targeting Technology Demonstration project

Science.gov (United States)

Edwards, Mark

2008-04-01

The Advanced Linked Extended Reconnaissance & Targeting (ALERT) Technology Demonstration (TD) project is addressing many operational needs of the future Canadian Army's Surveillance and Reconnaissance forces. Using the surveillance system of the Coyote reconnaissance vehicle as an experimental platform, the ALERT TD project aims to significantly enhance situational awareness by fusing multi-sensor and tactical data, developing automated processes, and integrating beyond line-of-sight sensing. The project is exploiting important advances made in computer processing capability, displays technology, digital communications, and sensor technology since the design of the original surveillance system. As the major research area within the project, concepts are discussed for displaying and fusing multi-sensor and tactical data within an Enhanced Operator Control Station (EOCS). The sensor data can originate from the Coyote's own visible-band and IR cameras, laser rangefinder, and ground-surveillance radar, as well as from beyond line-of-sight systems such as mini-UAVs and unattended ground sensors. Video-rate image processing has been developed to assist the operator to detect poorly visible targets. As a second major area of research, automatic target cueing capabilities have been added to the system. These include scene change detection, automatic target detection and aided target recognition algorithms processing both IR and visible-band images to draw the operator's attention to possible targets. The merits of incorporating scene change detection algorithms are also discussed. In the area of multi-sensor data fusion, up to Joint Defence Labs level 2 has been demonstrated. The human factors engineering aspects of the user interface in this complex environment are presented, drawing upon multiple user group sessions with military surveillance system operators. The paper concludes with Lessons Learned from the project. The ALERT system has been used in a number of C4ISR

Target technologies for laser inertial confinement fusion: state-of-the-art and future perspective

International Nuclear Information System (INIS)

Zhang Lin; Du Kai

2013-01-01

Targets are physical base of the laser inertial confinement fusion (ICF) researches. The quality of the targets has extremely important influences on the reliabilities and degree of precision of the ICF experimental results. The characteristics of the ICF targets, such as complexity and microscale, high precision, determine that the target fabrication process must be a system engineering. This paper presents progresses on the fabrication technologies of ICF targets. The existing problem and the future needs of ICF target fabrication technologies are also discussed. (authors)

OPTICAL correlation identification technology applied in underwater laser imaging target identification

Science.gov (United States)

Yao, Guang-tao; Zhang, Xiao-hui; Ge, Wei-long

2012-01-01

The underwater laser imaging detection is an effective method of detecting short distance target underwater as an important complement of sonar detection. With the development of underwater laser imaging technology and underwater vehicle technology, the underwater automatic target identification has gotten more and more attention, and is a research difficulty in the area of underwater optical imaging information processing. Today, underwater automatic target identification based on optical imaging is usually realized with the method of digital circuit software programming. The algorithm realization and control of this method is very flexible. However, the optical imaging information is 2D image even 3D image, the amount of imaging processing information is abundant, so the electronic hardware with pure digital algorithm will need long identification time and is hard to meet the demands of real-time identification. If adopt computer parallel processing, the identification speed can be improved, but it will increase complexity, size and power consumption. This paper attempts to apply optical correlation identification technology to realize underwater automatic target identification. The optics correlation identification technology utilizes the Fourier transform characteristic of Fourier lens which can accomplish Fourier transform of image information in the level of nanosecond, and optical space interconnection calculation has the features of parallel, high speed, large capacity and high resolution, combines the flexibility of calculation and control of digital circuit method to realize optoelectronic hybrid identification mode. We reduce theoretical formulation of correlation identification and analyze the principle of optical correlation identification, and write MATLAB simulation program. We adopt single frame image obtained in underwater range gating laser imaging to identify, and through identifying and locating the different positions of target, we can improve

Development of a Novel Targeted RNAi Delivery Technology inTherapies for Metabolic Diseases

Science.gov (United States)

2017-10-01

report Impact on other disciplines: Nothing to report Impact on technology transfer: Nothing to report Impact on society : Nothing to report 5. CHANGES...AWARD NUMBER: W81XWH-15-1-0569 TITLE: Development of a Novel Targeted RNAi Delivery Technology in Therapies for Metabolic Diseases PRINCIPAL...COVERED 30Sep2016 - 29Sep2017 4. TITLE AND SUBTITLE Development of a Novel Targeted RNAi Delivery Technology in Therapies for Metabolic Diseases 5a

Targeted Food Marketing to Youth: Engaging Professionals in an Online Environment

Science.gov (United States)

Katras, Mary Jo; Kunkel, Kelly; Croymans, Sara R.; Routh, Brianna; Schroeder, Mary; Olson, Carrie Ann

2014-01-01

The use of technology provides unique ways to create an engaged online community of learning for professionals that can be integrated into existing and future Extension programming. The Targeted Food Marketing to Youth online professional development course uses strategies and tools to create and support an engaged online community.

Reconfiguring global pharmaceutical value networks through targeted technology interventions

OpenAIRE

Harrington, Tomas Seosamh; Phillips, MA; Srai, Jagjit Singh

2016-01-01

Targeting a series of advanced manufacturing technology (AMT) ‘interventions’ provides the potential for significant step changes across the pharmaceutical value chain, from early stage ‘system discovery’ and clinical trials, through to novel service supply models. This research explores future value network configurations which, when aligned with disruptive shifts in technology (process and digital), may enable alternative routes to medicines production and the delivery of additional value t...

Measurement of casting parameters in ZnAlCu3 molds created by additive technology

Directory of Open Access Journals (Sweden)

S. Medić

2016-10-01

Full Text Available This paper examines the parameters of casting ZnAl4Cu3 alloy (volume, castability, density and occupancy of the mold in mold made additive technology. Molds made by additive technology are: cheaper in production of a small number of castings, geometrically more accurate and faster made. From obtained results of this paper it is clearly seen that printed mold must be protected with thermal coating because liquid adhesive of powder otherwise evaporates during casting and creates additional moisture in the mold, as it was noted.

Targeted Research and Technology Within NASA's Living With a Star Program

Science.gov (United States)

Antiochos, Spiro; Baker, Kile; Bellaire, Paul; Blake, Bern; Crowley, Geoff; Eddy, Jack; Goodrich, Charles; Gopalswamy, Nat; Gosling, Jack; Hesse, Michael

2004-01-01

Targeted Research & Technology (TR&T) NASA's Living With a Star (LWS) initiative is a systematic, goal-oriented research program targeting those aspects of the Sun-Earth system that affect society. The Targeted Research and Technology (TR&T) component of LWS provides the theory, modeling, and data analysis necessary to enable an integrated, system-wide picture of Sun-Earth connection science with societal relevance. Recognizing the central and essential role that TR&T would have for the success of the LWS initiative, the LWS Science Architecture Team (SAT) recommended that a Science Definition Team (SDT), with the same status as a flight mission definition team, be formed to design and coordinate a TR&T program having prioritized goals and objectives that focused on practical societal benefits. This report details the SDT recommendations for the TR&T program.

Using home networks to create atmospheres in the home: Technology push or (latent) user need?

NARCIS (Netherlands)

Kuiper-Hoyng, L.L.M.L.; Beusmans, J.W.F.

2004-01-01

The Atmosphere Controller is an implementation of home networking technology that could make life at home a totally new experience. An atmosphere is created by combining light (intensity and colour), music and wallpaper projection. To find out if is this type of experience fits into everyday life of

Target-Centric Network Modeling

DEFF Research Database (Denmark)

Mitchell, Dr. William L.; Clark, Dr. Robert M.

In Target-Centric Network Modeling: Case Studies in Analyzing Complex Intelligence Issues, authors Robert Clark and William Mitchell take an entirely new approach to teaching intelligence analysis. Unlike any other book on the market, it offers case study scenarios using actual intelligence...... reporting formats, along with a tested process that facilitates the production of a wide range of analytical products for civilian, military, and hybrid intelligence environments. Readers will learn how to perform the specific actions of problem definition modeling, target network modeling......, and collaborative sharing in the process of creating a high-quality, actionable intelligence product. The case studies reflect the complexity of twenty-first century intelligence issues by dealing with multi-layered target networks that cut across political, economic, social, technological, and military issues...

Clean Technology Evaluation & Workforce Development Program

Energy Technology Data Exchange (ETDEWEB)

Patricia Glaza

2012-12-01

The overall objective of the Clean Technology Evaluation portion of the award was to design a process to speed up the identification of new clean energy technologies and match organizations to testing and early adoption partners. The project was successful in identifying new technologies targeted to utilities and utility technology integrators, in developing a process to review and rank the new technologies, and in facilitating new partnerships for technology testing and adoption. The purpose of the Workforce Development portion of the award was to create an education outreach program for middle & high-school students focused on clean technology science and engineering. While originally targeting San Diego, California and Cambridge, Massachusetts, the scope of the program was expanded to include a major clean technology speaking series and expo as part of the USA Science & Engineering Festival on the National Mall in Washington, D.C.

Artificial Intelligence In Automatic Target Recognizers: Technology And Timelines

Science.gov (United States)

Gilmore, John F.

1984-12-01

The recognition of targets in thermal imagery has been a problem exhaustively analyzed in its current localized dimension. This paper discusses the application of artificial intelligence (AI) technology to automatic target recognition, a concept capable of expanding current ATR efforts into a new globalized dimension. Deficiencies of current automatic target recognition systems are reviewed in terms of system shortcomings. Areas of artificial intelligence which show the most promise in improving ATR performance are analyzed, and a timeline is formed in light of how near (as well as far) term artificial intelligence applications may exist. Current research in the area of high level expert vision systems is reviewed and the possible utilization of artificial intelligence architectures to improve low level image processing functions is also discussed. Additional application areas of relevance to solving the problem of automatic target recognition utilizing both high and low level processing are also explored.

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

Directory of Open Access Journals (Sweden)

Xiao-Hui Zhang

2015-01-01

Full Text Available CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%—RGEN (RNA-guided endonuclease-induced mutations at sites other than the intended on-target site—is one major concern, especially for therapeutic and clinical applications. Here, we review the basic mechanisms underlying off-target cutting in the CRISPR/Cas9 system, methods for detecting off-target mutations, and strategies for minimizing off-target cleavage. The improvement off-target specificity in the CRISPR/Cas9 system will provide solid genotype–phenotype correlations, and thus enable faithful interpretation of genome-editing data, which will certainly facilitate the basic and clinical application of this technology.

Pre-Service Teachers' Perception of and Technology Competency at Creating and Using E-Picture Books

Science.gov (United States)

Park, Yong Joon; Yang, Youjin

2013-01-01

This study investigated pre-service teachers' perception of and technology competency in creating and using e-picture books in their future classrooms. Participants were 114 pre-service teachers in a required Early Childhood Education undergraduate course at a mid-western university in the United States. As part of the course assignments,…

Research on infrared small-target tracking technology under complex background

Science.gov (United States)

Liu, Lei; Wang, Xin; Chen, Jilu; Pan, Tao

2012-10-01

In this paper, some basic principles and the implementing flow charts of a series of algorithms for target tracking are described. On the foundation of above works, a moving target tracking software base on the OpenCV is developed by the software developing platform MFC. Three kinds of tracking algorithms are integrated in this software. These two tracking algorithms are Kalman Filter tracking method and Camshift tracking method. In order to explain the software clearly, the framework and the function are described in this paper. At last, the implementing processes and results are analyzed, and those algorithms for tracking targets are evaluated from the two aspects of subjective and objective. This paper is very significant in the application of the infrared target tracking technology.

Creating the Future: Research and Technology

Science.gov (United States)

1998-01-01

With the many different technical talents, Marshall Space Flight Center (MSFC) continues to be an important force behind many scientific breakthroughs. The MSFC's annual report reviews the technology developments, research in space and microgravity sciences, studies in space system concepts, and technology transfer. The technology development programs include development in: (1) space propulsion and fluid management, (2) structures and dynamics, (3) materials and processes and (4) avionics and optics.

Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy

Directory of Open Access Journals (Sweden)

Chang WC

2014-06-01

Full Text Available Wen-Chung Chang,1,* Chin-Sheng Chen,2,* Hung-Chi Tai,3 Chia-Yuan Liu,4,5 Yu-Jen Chen3 1Department of Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan; 2Graduate Institute of Automation Technology, National Taipei University of Technology, Taipei, Taiwan; 3Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan; 4Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 5Department of Medicine, Mackay Medical College, New Taipei City, Taiwan  *These authors contributed equally to this work Abstract: The current practice of radiotherapy examines target coverage solely from digitally reconstructed beam's eye view (BEV in a way that is indirectly accessible and that is not in real time. We aimed to visualize treatment targets in real time from each BEV. The image data of phantom or patients from ultrasound (US and computed tomography (CT scans were captured to perform image registration. We integrated US, CT, US/CT image registration, robotic manipulation of US, a radiation treatment planning system, and a linear accelerator to constitute an innovative target visualization system. The performance of this algorithm segmented the target organ in CT images, transformed and reconstructed US images to match each orientation, and generated image registration in real time mode with acceptable accuracy. This image transformation allowed physicians to visualize the CT image-reconstructed target via a US probe outside the BEV that was non-coplanar to the beam's plane. It allowed the physicians to remotely control the US probe that was equipped on a robotic arm to dynamically trace and real time monitor the coverage of the target within the BEV during a simulated beam-on situation. This target visualization system may provide a direct remotely accessible and real time way to visualize, verify, and ensure tumor targeting during radiotherapy. Keywords: ultrasound, computerized tomography

Creating markets for efficient technologies by establishment of strategic niche markets

International Nuclear Information System (INIS)

Wene, Clas-Otto; Nilsson, Hans

2003-01-01

Creation of markets for more efficient technologies requires careful targeting of actors that have an interest in driving the process further. Such will both reduce the resources needed and make use of the actors self-interest for development and thus uphold the learning process. This is done by identification of strategic niche markets (SNM) where those suppliers and users, that have the biggest interest and benefit of the change will act. Both the identification and the development is a dynamic process that is better designed and operated by use of a triangulation method introduced by the IEA in its recent work

Long-Lifetime Low-Scatter Neutron Polarization Target

International Nuclear Information System (INIS)

Richardson, Jonathan M.

2004-01-01

Polarized neutrons scattering is an important technology for characterizing magnetic and other materials. Polarized helium three (P-3He) is a novel technology for creating polarized beams and, perhaps more importantly, for the analysis of polarization in highly divergent scattered beams. Analysis of scattered beams requires specialized targets with complex geometries to ensure accurate results. Special materials and handling procedures are required to give the targets a long useful lifetime. In most cases, the targets must be shielded from stray magnetic fields from nearby equipment. SRL has developed and demonstrated hybrid targets made from glass and aluminum. We have also developed and calibrated a low-field NMR system for measuring polarization lifetimes. We have demonstrated that our low-field system is able to measure NMR signals in the presence of conducting (metallic) cell elements. We have also demonstrated a non-magnetic valve that can be used to seal the cells. We feel that these accomplishments in Phase I are sufficient to ensure a successful Phase II program. The commercial market for this technology is solid. There are over nine neutron scattering centers in the US and Canada and over 22 abroad. Currently, the US plans to build a new $1.4B scattering facility called the Spallation Neutron Source (SNS). The technology developed in this project will allow SRL to supply targets to both existing and future facilities. SRL is also involved with the application of P-3He to medical imaging

Biofuels development in China: Technology options and policies needed to meet the 2020 target

International Nuclear Information System (INIS)

Chang, Shiyan; Zhao, Lili; Timilsina, Govinda R.; Zhang, Xiliang

2012-01-01

China promulgated the Medium and Long-Term Development Plan for Renewable Energy in 2007, which included sub-targets of 2010 and 2020 for various renewable energy technologies. Almost all the 2010 sub-targets have been met and even surpassed except non-grain fuel ethanol. There is debate surrounding the questions of whether and how the country will be able to meet the 2020 biofuels target. This paper provides the assessment of potential technology pathways to achieve the 2020 target regarding their respective resource potential and supply cost. Barriers and policy options are identified based on broad literatures review. And an overview of biofuels projections is presented to provide insight into the comparison of various policy scenarios. The study shows that China can potentially satisfy non-grain fuel ethanol target by 2020 from technology perspective. But she will probably fall far short of this target if current situations continue. Additional policy efforts are needed. Meanwhile, the target of biodiesel production has high probability to be achieved. However, if given support policies, it will develop better. - Highlights: ► I. Non-grain feedstocks such as cassava, sweet sorghum and sweet potato grown in low productive arable lands or unutilized lands have enough potential to meet ethanol targets in 2020. ► II. If current situations continue, China will fall far short of the 2020 target. ► III. The target of biodiesel production has high probability to be achieved, while, if given support policies, it will develop better. ► IV. Supply cost is one of the major barriers faced by all biofuels pathways. ► V. Various policy measures would be necessary to overcome the costs barriers to biofuels in China.

Media, Information Technology, and Language Planning: What Can Endangered Language Communities Learn from Created Language Communities?

Science.gov (United States)

Schreyer, Christine

2011-01-01

The languages of Klingon and Na'vi, both created for media, are also languages that have garnered much media attention throughout the course of their existence. Speakers of these languages also utilize social media and information technologies, specifically websites, in order to learn the languages and then put them into practice. While teaching a…

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments.

Science.gov (United States)

MacLean, Brendan; Tomazela, Daniela M; Shulman, Nicholas; Chambers, Matthew; Finney, Gregory L; Frewen, Barbara; Kern, Randall; Tabb, David L; Liebler, Daniel C; MacCoss, Michael J

2010-04-01

Skyline is a Windows client application for targeted proteomics method creation and quantitative data analysis. It is open source and freely available for academic and commercial use. The Skyline user interface simplifies the development of mass spectrometer methods and the analysis of data from targeted proteomics experiments performed using selected reaction monitoring (SRM). Skyline supports using and creating MS/MS spectral libraries from a wide variety of sources to choose SRM filters and verify results based on previously observed ion trap data. Skyline exports transition lists to and imports the native output files from Agilent, Applied Biosystems, Thermo Fisher Scientific and Waters triple quadrupole instruments, seamlessly connecting mass spectrometer output back to the experimental design document. The fast and compact Skyline file format is easily shared, even for experiments requiring many sample injections. A rich array of graphs displays results and provides powerful tools for inspecting data integrity as data are acquired, helping instrument operators to identify problems early. The Skyline dynamic report designer exports tabular data from the Skyline document model for in-depth analysis with common statistical tools. Single-click, self-updating web installation is available at http://proteome.gs.washington.edu/software/skyline. This web site also provides access to instructional videos, a support board, an issues list and a link to the source code project.

Creating an effective system of quality management in health care organizations through the implementation of technology lean production

Directory of Open Access Journals (Sweden)

M. A. Gurina

2017-01-01

Full Text Available In the conditions of changing management paradigm in the public sphere, strengthening political, economic, social and technological risks on the part of stakeholders of medical organizations, there is a need to create an effective quality management system based on the technology of lean production. This system is aimed at increasing the satisfaction of consumers of medical services, reducing the labor losses of medical personnel, improving the quality and productivity of labor in medical organizations. The use of lin-production in the framework of pilot projects implemented in Russia for the last three years shows significant advantages in the work of medical organizations in comparison with traditional approaches in the organization of the provision of services by polyclinics. In the article, step-by-step organization of the work on creating a thrifty polyclinic is considered.

Creating Instructional Environments that Keep Students on TARGET

Science.gov (United States)

Boyce, B. Ann

2009-01-01

Teachers' instructional decisions, such as lesson goals, how students are grouped, or how students are recognized and evaluated, can affect their students' level of motivation related to physical activity. A physical educator's primary responsibility is to create a classroom environment that enhances motivation and fosters positive attitudes and…

Creating smart contracts using blockchain technology

OpenAIRE

Baronas, Erikas

2018-01-01

This paper presents Blockchain, crypto-currencie’s core technology analysis and smart cont- racts potentialities research. Bringing up two frameworks - Ethereum and Bitcoin - helps to un- derstand the principles of how decentralized system work and what solutions ensure data integrity and immutability in both technologies. The main goal of this work - prove, that smart contracts can be used in real world system model. Paper egzamines prototypes, which increase exponentially by their complexit...

Creating a sustainable energy future for Australia

International Nuclear Information System (INIS)

Sonneborn, C.L.

1995-01-01

A joint industry approach is needed to put in place a sustainable energy system that is economically and technologically feasible. The industry sectors involved must include the renewable energy industry, energy efficiency industry and the natural gas industry. Conventional forecasts of energy futures make far less use of these industries than is economically and technically feasible. Existing forecasts make the trade off between acceptable levels of economic growth, limitation of greenhouse gases and dependence on coal and oil appear more difficult than they actually are and overlook the benefits of sustainable energy industry development. This paper outlines how national gains from carefully targeted action can exceed national losses while substantially reducing greenhouse gases and creating jobs at zero or negative costs. (author). 3 figs., 27 refs

Realizing Technologies for Magnetized Target Fusion

Energy Technology Data Exchange (ETDEWEB)

Wurden, Glen A. [Los Alamos National Laboratory

2012-08-24

Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

A business strategy formulation for commercializing university-created technology: A university spin-offs

Science.gov (United States)

Saputra, Iqbal Wahyu; Sutopo, Wahyudi; Zakaria, Roni

2018-02-01

There are some mechanism to commercialize the innovations that have been developed by academic scientists in universities, i.e. patenting, licensing, start-up creation, and university-industry partnerships. The start-up creations or university spin-offs (USOs) company is a very special start-up company that is founded by an academic inventor and the university with the aim to commercialize the technological innovation that created by the university. However, it is not always as smooth as expected. The market competitiveness of the USOs obviously has many challenges to be able to compete with the existing companies, analysis need to be done to get the right business step so the business strategy will be efficient. In this article, we discuss a real case study of a university spin-off that owned by Sebelas Maret University for Commercializing Battery Lithium. The aim of our research is twofold: first, to identify the gap in the literature of business strategy formulation between a conventional and USOs. Second, to propose a business strategy formulation for commercializing university-created technology, i.e. battery lithium as core business of a university spin-off as a case study. We conduct surveys, observation and FGD in order to collect the data and information to build the company objective and goals. The analytical tools to generate the solution of business strategy are SWOT analysis, IFE-EFE matrix, and QSPM model so the result will be the most attractive and suitable for the company. The result shows that the case study of USO company is classified on conservative continuous improvement phase so the suitable strategy for this company are product development and business strategy integration.

Solar Europe industry initiative: research technology development and demonstration in support of 2020 and long-term targets

NARCIS (Netherlands)

Sinke, W.C.; Fraile Montoro, D.; Despotou, E.; Nowak, S.; Perezagua, E.

2010-01-01

The European Union has set an ambitious target for the implementation of renewable energy technologies by 2020, i.e. a share of 20% of the total energy consumption. In support of these targets the Strategic Energy Technology (SET) Plan has been initiated by the European Commission. One of the key

Decision Analysis and Policy Formulation for Technology-Specific Renewable Energy Targets

Science.gov (United States)

Okioga, Irene Teshamulwa

This study establishes a decision making procedure using Analytic Hierarchy Process (AHP) for a U.S. national renewable portfolio standard, and proposes technology-specific targets for renewable electricity generation for the country. The study prioritizes renewable energy alternatives based on a multi-perspective view: from the public, policy makers, and investors' points-of-view, and uses multiple criteria for ranking the alternatives to generate a unified prioritization scheme. During this process, it considers a 'quadruple bottom-line' approach (4P), i.e. reflecting technical "progress", social "people", economic 'profits", and environmental "planet" factors. The AHP results indicated that electricity generation from solar PV ranked highest, and biomass energy ranked lowest. A "Benefits/Cost Incentives/Mandates" (BCIM) model was developed to identify where mandates are needed, and where incentives would instead be required to bring down costs for technologies that have potential for profitable deployment. The BCIM model balances the development of less mature renewable energy technologies, without the potential for rising near-term electricity rates for consumers. It also ensures that recommended policies do not lead to growth of just one type of technology--the "highest-benefit, least-cost" technology. The model indicated that mandates would be suited for solar PV, and incentives generally for geothermal and concentrated solar power. Development for biomass energy, as a "low-cost, low-benefits" alternative was recommended at a local rather than national level, mainly due to its low resource potential values. Further, biomass energy generated from wastewater treatment plants (WWTPs) had the least resource potential compared to other biomass sources. The research developed methodologies and recommendations for biogas electricity targets at WWTPs, to take advantage of the waste-to-energy opportunities.

The technology benefits of inertial confinement fusion research

International Nuclear Information System (INIS)

Powell, H.T.

1999-01-01

The development and demonstration of inertial fusion is incredibly challenging because it requires simultaneously controlling and precisely measuring parameters at extreme values in energy, space, and time. The challenges range from building megajoule (10 6 J) drivers that perform with percent-level precision to fabricating targets with submicron specifications to measuring target performance at micron scale (10 -6 m) with picosecond (10 -12 s) time resolution. Over the past 30 years in attempting to meet this challenge, the inertial fusion community around the world has invented new technologies in lasers, particle beams, pulse power drivers, diagnostics, target fabrication, and other areas. These technologies have found applications in diverse fields of industry and science. Moreover, simply assembling the teams with the background, experience, and personal drive to meet the challenging requirements of inertial fusion has led to spin-offs in unexpected directions, for example, in laser isotope separation, extreme ultraviolet lithography for microelectronics, compact and inexpensive radars, advanced laser materials processing, and medical technology. The experience of inertial fusion research and development of spinning off technologies has not been unique to any one laboratory or country but has been similar in main research centers in the US, Europe, and Japan. Strengthening and broadening the inertial fusion effort to focus on creating a new source of electrical power (inertial fusion energy [IFE]) that is economically competitive and environmentally benign will yield rich rewards in technology spin-offs. The additional challenges presented by IFE are to make drivers affordable, efficient, and long-lived while operating at a repetition rate of a few Hertz; to make fusion targets that perform consistently at high-fusion yield; and to create target chambers that can repetitively handle greater than 100-MJ yields while producing minimal radioactive by

Gene targeting in adult rhesus macaque fibroblasts

Directory of Open Access Journals (Sweden)

Wolf Don P

2008-03-01

Full Text Available Abstract Background Gene targeting in nonhuman primates has the potential to produce critical animal models for translational studies related to human diseases. Successful gene targeting in fibroblasts followed by somatic cell nuclear transfer (SCNT has been achieved in several species of large mammals but not yet in primates. Our goal was to establish the protocols necessary to achieve gene targeting in primary culture of adult rhesus macaque fibroblasts as a first step in creating nonhuman primate models of genetic disease using nuclear transfer technology. Results A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro manipulations. Successful gene targeting of the HPRT locus in rhesus macaques was achieved by electroporating S-phase synchronized cells with a construct containing a SV40 enhancer. Conclusion The cell lines reported here could be used for the production of null mutant rhesus macaque models of human genetic disease using SCNT technology. In addition, given the close evolutionary relationship and biological similarity between rhesus macaques and humans, the protocols described here may prove useful in the genetic engineering of human somatic cells.

Elucidating antimalarial drug targets/mode-of-action by application of system biology technologies

CSIR Research Space (South Africa)

Becker, J

2008-11-01

Full Text Available targets/mode-of-action by application of systems biology technologies J BECKER, L MTWISHA, B CRAMPTON AND D MANCAMA CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa Email: JBecker@csir.co.za – www.csir.co.za INTRODUCTION Malaria is one... The objective of this study was to use systems biology tools to unravel the drug target/mode-of-action (MoA) of an antimalarial drug (cyclohexylamine) with a known drug target/MoA, by analysing differential expression profiles of drug treated vs untreated...

The never-ending digital journey creating new consumer experiences through technology

CERN Document Server

Angelani, Andres; Migoya, Martin

2016-01-01

The Never-Ending Digital Journey provides readers with the concepts and steps needed to create successful user experiences. The authors look ahead and explore digital scenarios of the future. They probe how technology is changing the way users interact with brands, and they address today's digital challenges with new ways of surprising consumers, integrating design and engineering. The authors leverage knowledge gleaned from working with renowned global companies to describe the recipe needed to build a Digital Journey. With a strong focus on Agile Pods, they dive into technolo- gies, processes, team building, motivation, and met- rics that enable businesses to construct and nurture the dynamic ecosystems necessary in this digital era to foster success. Over the last several years, customers, employees, and partners have become tech-savvy users whose expectations of “Give me more and deliver it faster" require manageable solutions. The desire to interact with digital ecosystems anywhere, anytime demands that...

Cooperation Mechanisms To Achieve Eu Renewable Targets

DEFF Research Database (Denmark)

Klinge Jacobsen, Henrik; Pade, Lise-Lotte; Schröder, Sascha Thorsten

2014-01-01

targets. Furthermore, countries might find themselves competing for investment in a market with limited capital available. In both cases, the cost-efficiency of the renewable support policies is reduced compared to a coordinated solution. Barriers for joint support such as network regulation regarding......There are considerable benefits from cooperating among member states on meeting the 2020 renewable energy sources (RES) targets. Today countries are supporting investments in renewable energy by many different types of support schemes and with different levels of support. The EU has opened...... for cooperation mechanisms such as joint support schemes for promoting renewable energy to meet the 2020 targets. The potential coordination benefits, with more efficient localisation and composition of renewable investment, can be achieved by creating new areas/sub-segments of renewable technologies where...

Evaluation of a novel ultra small target technology supporting on-product overlay measurements

Science.gov (United States)

Smilde, Henk-Jan H.; den Boef, Arie; Kubis, Michael; Jak, Martin; van Schijndel, Mark; Fuchs, Andreas; van der Schaar, Maurits; Meyer, Steffen; Morgan, Stephen; Wu, Jon; Tsai, Vincent; Wang, Cathy; Bhattacharyya, Kaustuve; Chen, Kai-Hsiung; Huang, Guo-Tsai; Ke, Chih-Ming; Huang, Jacky

2012-03-01

Reducing the size of metrology targets is essential for in-die overlay metrology in advanced semiconductor manufacturing. In this paper, μ-diffraction-based overlay (μDBO) measurements with a YieldStar metrology tool are presented for target-sizes down to 10 × 10 μm2. The μDBO technology enables selection of only the diffraction efficiency information from the grating by efficiently separating it from product structure reflections. Therefore, μDBO targets -even when located adjacent to product environment- give excellent correlation with 40 × 160 μm2 reference targets. Although significantly smaller than standard scribe-line targets, they can achieve total-measurement-uncertainty values of below 0.5 nm on a wide range of product layers. This shows that the new μDBO technique allows for accurate metrology on ultra small in-die targets, while retaining the excellent TMU performance of diffraction-based overlay metrology.

[Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities].

Science.gov (United States)

Fan, Xiang-yu; Lin, Yan-ping; Liao, Guo-jian; Xie, Jian-ping

2015-12-01

Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.

The advanced linked extended reconnaissance and targeting technology demonstration project

Science.gov (United States)

Cruickshank, James; de Villers, Yves; Maheux, Jean; Edwards, Mark; Gains, David; Rea, Terry; Banbury, Simon; Gauthier, Michelle

2007-06-01

The Advanced Linked Extended Reconnaissance & Targeting (ALERT) Technology Demonstration (TD) project is addressing key operational needs of the future Canadian Army's Surveillance and Reconnaissance forces by fusing multi-sensor and tactical data, developing automated processes, and integrating beyond line-of-sight sensing. We discuss concepts for displaying and fusing multi-sensor and tactical data within an Enhanced Operator Control Station (EOCS). The sensor data can originate from the Coyote's own visible-band and IR cameras, laser rangefinder, and ground-surveillance radar, as well as beyond line-of-sight systems such as a mini-UAV and unattended ground sensors. The authors address technical issues associated with the use of fully digital IR and day video cameras and discuss video-rate image processing developed to assist the operator to recognize poorly visible targets. Automatic target detection and recognition algorithms processing both IR and visible-band images have been investigated to draw the operator's attention to possible targets. The machine generated information display requirements are presented with the human factors engineering aspects of the user interface in this complex environment, with a view to establishing user trust in the automation. The paper concludes with a summary of achievements to date and steps to project completion.

CRISPR-DT: designing gRNAs for the CRISPR-Cpf1 system with improved target efficiency and specificity

OpenAIRE

Liang, Chun; Zhu, Houxiang

2018-01-01

The CRISPR-Cpf1 system has been successfully applied in genome editing. However, target efficiency of the CRISPR-Cpf1 system varies among different gRNA sequences. We reanalyzed the published CRISPR-Cpf1 gRNAs data and found many sequence and structural features related to their target efficiency. Using machine learning technology, a SVM model was created to predict target efficiency for any given gRNAs. We have developed the first web service application, CRISPR-DT (CRISPR DNA Targeting), to...

SciDAC visualization and analytics center for enabling technology

International Nuclear Information System (INIS)

Bethel, E Wes; Johnson, Chris; Joy, Ken; Ahern, Sean; Pascucci, Valerio; Childs, Hank; Cohen, Jonathan; Duchaineau, Mark; Hamann, Bernd; Hansen, Charles; Laney, Dan; Lindstrom, Peter; Meredith, Jeremy; Ostrouchov, George; Parker, Steven; Silva, Claudio; Sanderson, Allen; Tricoche, Xavier

2007-01-01

The Visualization and Analytics Center for Enabling Technologies (VACET) focuses on leveraging scientific visualization and analytics software technology as an enabling technology for increasing scientific productivity and insight. Advances in computational technology have resulted in an 'information big bang,' which in turn has created a significant data understanding challenge. This challenge is widely acknowledged to be one of the primary bottlenecks in contemporary science. The vision of VACET is to adapt, extend, create when necessary, and deploy visual data analysis solutions that are responsive to the needs of DOE's computational and experimental scientists. Our center is engineered to be directly responsive to those needs and to deliver solutions for use in DOE's large open computing facilities. The research and development directly target data understanding problems provided by our scientific application stakeholders. VACET draws from a diverse set of visualization technology ranging from production quality applications and application frameworks to state-of-the-art algorithms for visualization, analysis, analytics, data manipulation, and data management

Strand Invasion Based Amplification (SIBA®): a novel isothermal DNA amplification technology demonstrating high specificity and sensitivity for a single molecule of target analyte.

Science.gov (United States)

Hoser, Mark J; Mansukoski, Hannu K; Morrical, Scott W; Eboigbodin, Kevin E

2014-01-01

Isothermal nucleic acid amplification technologies offer significant advantages over polymerase chain reaction (PCR) in that they do not require thermal cycling or sophisticated laboratory equipment. However, non-target-dependent amplification has limited the sensitivity of isothermal technologies and complex probes are usually required to distinguish between non-specific and target-dependent amplification. Here, we report a novel isothermal nucleic acid amplification technology, Strand Invasion Based Amplification (SIBA). SIBA technology is resistant to non-specific amplification, is able to detect a single molecule of target analyte, and does not require target-specific probes. The technology relies on the recombinase-dependent insertion of an invasion oligonucleotide (IO) into the double-stranded target nucleic acid. The duplex regions peripheral to the IO insertion site dissociate, thereby enabling target-specific primers to bind. A polymerase then extends the primers onto the target nucleic acid leading to exponential amplification of the target. The primers are not substrates for the recombinase and are, therefore unable to extend the target template in the absence of the IO. The inclusion of 2'-O-methyl RNA to the IO ensures that it is not extendible and that it does not take part in the extension of the target template. These characteristics ensure that the technology is resistant to non-specific amplification since primer dimers or mis-priming are unable to exponentially amplify. Consequently, SIBA is highly specific and able to distinguish closely-related species with single molecule sensitivity in the absence of complex probes or sophisticated laboratory equipment. Here, we describe this technology in detail and demonstrate its use for the detection of Salmonella.

Strand Invasion Based Amplification (SIBA®: a novel isothermal DNA amplification technology demonstrating high specificity and sensitivity for a single molecule of target analyte.

Directory of Open Access Journals (Sweden)

Mark J Hoser

Full Text Available Isothermal nucleic acid amplification technologies offer significant advantages over polymerase chain reaction (PCR in that they do not require thermal cycling or sophisticated laboratory equipment. However, non-target-dependent amplification has limited the sensitivity of isothermal technologies and complex probes are usually required to distinguish between non-specific and target-dependent amplification. Here, we report a novel isothermal nucleic acid amplification technology, Strand Invasion Based Amplification (SIBA. SIBA technology is resistant to non-specific amplification, is able to detect a single molecule of target analyte, and does not require target-specific probes. The technology relies on the recombinase-dependent insertion of an invasion oligonucleotide (IO into the double-stranded target nucleic acid. The duplex regions peripheral to the IO insertion site dissociate, thereby enabling target-specific primers to bind. A polymerase then extends the primers onto the target nucleic acid leading to exponential amplification of the target. The primers are not substrates for the recombinase and are, therefore unable to extend the target template in the absence of the IO. The inclusion of 2'-O-methyl RNA to the IO ensures that it is not extendible and that it does not take part in the extension of the target template. These characteristics ensure that the technology is resistant to non-specific amplification since primer dimers or mis-priming are unable to exponentially amplify. Consequently, SIBA is highly specific and able to distinguish closely-related species with single molecule sensitivity in the absence of complex probes or sophisticated laboratory equipment. Here, we describe this technology in detail and demonstrate its use for the detection of Salmonella.

Inertial Confinement Fusion Target Component Fabrication and Technology Development report

International Nuclear Information System (INIS)

Steinman, D.

1994-03-01

On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities which took place under this contract during the period of October 1, 1992 through September 30, 1993. During this period, GA was assigned 18 tasks in support of the Inertial Confinement Fusion program and its laboratories. These tasks included ''Capabilities Activation'' and ''Capabilities Demonstration'' to enable us to begin production of glass and composite polymer capsules. Capsule delivery tasks included ''Small Glass Shell Deliveries'' and ''Composite Polymer Capsules'' for Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL). We also were asked to provide direct ''Onsite Support'' at LLNL and LANL. We continued planning for the transfer of ''Micromachining Equipment from Rocky Flats'' and established ''Target Component Micromachining and Electroplating Facilities'' at GA. We fabricated over 1100 films and filters of 11 types for Sandia National Laboratory and provided full-time onsite engineering support for target fabrication and characterization. We initiated development of methods to make targets for the Naval Research Laboratory. We investigated spherical interferometry, built an automated capsule sorter, and developed an apparatus for calorimetric measurement of fuel fill for LLNL. We assisted LANL in the ''Characterization of Opaque b-Layered Targets.'' We developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process

Creating Porcine Biomedical Models Through Recombineering

Directory of Open Access Journals (Sweden)

Lawrence B. Schook

2006-03-01

Full Text Available Recent advances in genomics provide genetic information from humans and other mammals (mouse, rat, dog and primates traditionally used as models as well as new candidates (pigs and cattle. In addition, linked enabling technologies, such as transgenesis and animal cloning, provide innovative ways to design and perform experiments to dissect complex biological systems. Exploitation of genomic information overcomes the traditional need to choose naturally occurring models. Thus, investigators can utilize emerging genomic knowledge and tools to create relevant animal models. This approach is referred to as reverse genetics. In contrast to ‘forward genetics’, in which gene(s responsible for a particular phenotype are identified by positional cloning (phenotype to genotype, the ‘reverse genetics’ approach determines the function of a gene and predicts the phenotype of a cell, tissue, or organism (genotype to phenotype. The convergence of classical and reverse genetics, along with genomics, provides a working definition of a ‘genetic model’ organism (3. The recent construction of phenotypic maps defining quantitative trait loci (QTL in various domesticated species provides insights into how allelic variations contribute to phenotypic diversity. Targeted chromosomal regions are characterized by the construction of bacterial artificial chromosome (BAC contigs to isolate and characterize genes contributing towards phenotypic variation. Recombineering provides a powerful methodology to harvest genetic information responsible for phenotype. Linking recombineering with gene-targeted homologous recombination, coupled with nuclear transfer (NT technology can provide ‘clones’ of genetically modified animals.

creating social presence in large classes

African Journals Online (AJOL)

Social presence refers to the ability of students to project themselves as 'real people' in an online learning community. While it is difficult to create social presence in large classes, educational technologies can enhance the social dimension of online learning if educators relinquish the use of technology as an instrument of ...

GIS-technologies as a mechanism to study geological structures

Science.gov (United States)

Sharapatov, Abish

2014-05-01

Specialized GIS-technologies allow creating multi-parameter models, completing multi-criteria optimisation tasks, and issues of geological profile forecasts using miscellaneous data. Pictorial and attributive geological and geophysical information collected to create GIS database is supplemented by the ERS (Earth's Remote Sensing) data, air spectrometry, space images, and topographic data. Among the important tasks are as follows: a unification of initial geological, geophysical and other types of information on a tectonic position, rock classification and stratigraphic scale; topographic bases (various projectures, scales); the levels of detail and exhaustibility; colors and symbols of legends; data structures and their correlation; units of measurement of physical quantities, and attribute systems of descriptions. Methods of the geological environment investigation using GIS-technology are based on a principle of the research target analogy with a standard. A similarity ratio is quantitative estimate. A geological forecast model is formed by structuring of geological information based on detailed analysis and aggregation of geological and formal knowledge bases on standard targets. Development of a bank of models of the analyzed geological structures of various range, ore-bearing features described by numerous prospecting indicators is the way to aggregate geological knowledge. The south terrain of the Valerianovskaya structure-facies zone (SFZ) of the Torgai paleo-rift structure covered with thick Mesozoic and Cenozoic rocks up to 2,000m is considered a so-called training ground for the development of GIS-technology. Parameters of known magnetite deposits located in the north of the SFZ (Sarybaiskoye, Sokolovskoye, etc.) are used to create the standard model. A meaning of the job implemented involves the following: - A goal-seeking nature of the research being performed and integration of the geological, geo-physical and other data (in many cases, efforts of the

Competence formation of engineering directions students in the field of energy saving as a way to create new generation technologies

Science.gov (United States)

Gilmanshin, I. R.; Gilmanshina, S. I.

2017-09-01

The urgency of the formation of competence in the field of energy saving in the process of studying engineering and technical disciplines at the university is substantiated. The author’s definition of the competence in the field of energy saving is given, allowing to consider the necessity of its formation among students - future engineers as a way to create technologies of a new generation. The essence of this competence is revealed. The system of work, pedagogical conditions and technologies of its formation in the conditions of the federal university is substantiated.

The value of advanced technology in meeting 2050 greenhouse gas emissions targets in the United States

International Nuclear Information System (INIS)

Kyle, Page; Clarke, Leon; Pugh, Graham; Wise, Marshall; Calvin, Kate; Edmonds, James; Kim, Son

2009-01-01

This paper, a contribution to the EMF 22 subgroup on Transition Scenarios, examines the relationship between technology evolution over the next 40 years and the cost, energy, and greenhouse gas emissions consequences of possible U.S. mitigation goals. The paper explores these issues within the context of cumulative emissions targets based on linear reductions in CO 2 -e emissions of 50% and 80% below 1990 levels by 2050. Six technology futures were constructed within the MiniCAM integrated assessment model and then applied to the emissions targets. The paper explores the influence of technology availability and expectations of future technology availability on the economic consequences of emissions mitigation, on the time path of emissions mitigation, and on the evolution of the U.S. energy system over time. One of the strongest themes to emerge from the scenarios in this study is that near-term decision-making depends on the availability of technology decades into the future, when deep emissions reductions are required to meet the cumulative emissions goals. In the scenarios in this paper, it is the expectations about future technology that have the most dramatic effect on greenhouse gas emissions prices and emissions reductions in 2020, as opposed to near-term technology availability. Moreover, it is the nature of technology 20, 30, and 40 years out, rather than availability and deployment of technology in the next decade, that will largely determine the character of the mid-century energy system.

Report on achievements in fiscal 1999. Research and development of advanced function creating and processing technologies; 1990 nendo senshin kino soshutsu kako gijutsu no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1991-03-01

In order to provide materials with superior advanced functions such as high-level biological compatibility, external environment identifying function, chemical reaction activating function, high-performance electromagnetic properties, and corrosion and heat resistant high strength properties, it is intended to establish novel material creating technologies using chemical processing processes that can control finely the compositions and constructions of the materials. The efforts include (1) works on research and development of an ultra-high purity separating technology composed mainly of laser selection and excitation actions for manifestation of new natures such as sensing function, catalytic function, and electromagnetic properties, (2) works on research and development of a micro-fine crystal controlling technology capable of designing materials, such as micro-fine particle synthesizing, dispersing and compounding technologies, micro thin film lamination, and interface controlling technologies to create materials having high strength as well as high tenacity, and (3) works on research and development of high-function organic material synthesizing technologies compounding the utilization of high-grade photons with application of extreme environmental fields such as ferromagnetic fields whose effects are expected on controlling structure like orientation of atomic and molecular levels for the purpose of creating high-function materials having high heat resistance, corrosion resistance, and lubrication performance. (NEDO)

Targeted Technology Transfer to US Independents

Energy Technology Data Exchange (ETDEWEB)

Schatzinger, Viola [Petroleum Tech. Transfer Council, Tulsa, OK (United States); Chapman, Kathy [Petroleum Tech. Transfer Council, Tulsa, OK (United States); Lovendahl, Kristi [Petroleum Tech. Transfer Council, Tulsa, OK (United States)

2014-09-30

-year contract with the Department of Energy (DOE) for providing technology transfer services. This report summarizes activity and results during for five years, FY10 through FY14. In FY12 changes occurred in responsibilities of consultants serving HQ, because funding was reduced below the threshold level of $500,000 audits were no longer required and consultant time was reduced on the primary contract. Contracts for Permian Carbon Capture Utilization and Storage (CCUS) training, and providing tech transfer services to the Research Partnership to Secure Energy for America (RPSEA) provided work that enabled HQ to retain services of regular consultants. Both CCUS and RPSEA were five year contracts with PTTC, and providing services for these DOE funded contracts provided synergy for PTTC and the oil and gas industry. With further decreases in DOE funding the regions conducted workshops with no PTTC funding starting in June FY11. Since 2011 the number of workshops has declined from 79 in FY10 and FY11 to 49 in FY12, and risen to 54 in FY13 and 63 in FY14. The attendee's numbers dipped slightly below 3,000 per year in FY 10, FY12, and FY13, but rose to over 3,800 in FY 11 and 3105 in FY14. Quantitative accomplishments: PTTC has maintained its unique structure of a national organization working through Regional Lead Organizations (RLOs) to deliver local, affordable workshops. During the contract period PTTC consolidated from 10 to five regions to increase efficiency, and because no active RLO's would be maintained in the Central and Eastern Gulf Coast regions. RLO's for the regions are located at: Eastern - West Virginia University, (Illinois Geol. Survey., W. Michigan Univ. FY10-12); Midwest created in FY13 - Illinois Geological Survey, W. Michigan University; Midcontinent - University of Kansas, expanded to Houston, TX (2013-14); Rocky Mountain - Colorado School of Mines; Texas/SE New Mexico (FY10-FY11) - Bureau of Economic Geology, Univ. of Texas at Austin; West

Marketing Plan for the National Security Technology Incubator

Energy Technology Data Exchange (ETDEWEB)

None

2008-03-31

This marketing plan was developed as part of the National Security Preparedness Project by the Arrowhead Center of New Mexico State University. The vision of the National Security Technology Incubator program is to be a successful incubator of technologies and private enterprise that assist the NNSA in meeting new challenges in national safety and security. The plan defines important aspects of developing the incubator, such as defining the target market, marketing goals, and creating strategies to reach the target market while meeting those goals. The three main marketing goals of the incubator are: 1) developing marketing materials for the incubator program; 2) attracting businesses to become incubator participants; and 3) increasing name recognition of the incubator program on a national level.

A novel technology to target adenovirus vectors : application in cells involved in atherosclerosis

NARCIS (Netherlands)

Gras, Jan Cornelis Emile

2007-01-01

In this thesis a novel technology is described to target adenovirus vectors. Adenovirus vectors are powerful tools to modulate gene expression. The use of these vectors however, is hampered by the fact that many for gene therapy interesting cell types do not, or only at low levels express the CAR

Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets.

Science.gov (United States)

Wong, Vincent Kam-Wai; Law, Betty Yuen-Kwan; Yao, Xiao-Jun; Chen, Xi; Xu, Su Wei; Liu, Liang; Leung, Elaine Lai-Han

2016-09-01

Traditional biotechnology has been utilized by human civilization for long in wide aspects of our daily life, such as wine and vinegar production, which can generate new phytochemicals from natural products using micro-organism. Today, with advanced biotechnology, diverse applications and advantages have been exhibited not only in bringing benefits to increase the diversity and composition of herbal phytochemicals, but also helping to elucidate the treatment mechanism and accelerate new drug discovery from Chinese herbal medicine (CHM). Applications on phytochemical biotechnologies and microbial biotechnologies have been promoted to enhance phytochemical diversity. Cell labeling and imaging technology and -omics technology have been utilized to elucidate CHM treatment mechanism. Application of computational methods, such as chemoinformatics and bioinformatics provide new insights on direct target of CHM. Overall, these technologies provide efficient ways to overcome the bottleneck of CHM, such as helping to increase the phytochemical diversity, match their molecular targets and elucidate the treatment mechanism. Potentially, new oriented herbal phytochemicals and their corresponding drug targets can be identified. In perspective, tighter integration of multi-disciplinary biotechnology and computational technology will be the cornerstone to accelerate new arena formation, advancement and revolution in the fields of CHM and world pharmaceutical industry. Copyright © 2016 Elsevier Ltd. All rights reserved.

Let nuclear technology create new brilliancy for china's sustainable development

International Nuclear Information System (INIS)

Du Xiangwan

2008-01-01

This paper summarizes the development and application directions of nuclear technology, including five aspects: nuclear technology and energy nuclear technology and medicine, nuclear anclear analysis technology, nuclear radiation technology, astronautics and voyage's nuclear power, etc. The paper discusses the importance of them to sustainable development and generalizes the development trilogy of nuclear science and technology and its prospect. (authors)

Technology strategy for gas technologies; Technology Target Areas; TTA8 Gas Technology

Energy Technology Data Exchange (ETDEWEB)

2008-07-01

TTA8 - Gas technologies points out the various routes Norway can follow to capitalise on the vast resources of natural gas that will be produced in the years to come by developing a strong technology and competence platform. A broad view is taken for the value creation having as basis the continued gas export from NCS to Europe, but also a strong focus on development of gas resources in other parts of the world. The latter can also be seen as part of international positioning for upstream resources and does also include involvements in projects, and export of technology and products. The TTA has structured the analysis into 3 main areas: Gas transport and processing (pipeline, LNG, other); Gas conversion to fuels, chemicals and materials; CO{sub 2} management. In this report, for each of these areas, scenarios based on a gap analysis are presented. One of the key goals has been to identify pacing and emerging technologies for the next 20 years. Based on this, technologies have been mapped according to importance for future competitiveness and technology ambitions. This also includes primary funding responsibilities (public and/or industry). The road map below reflects the key issues in the proposed strategy. The base level of the figure explains areas that will have to be pursued to maintain Norway's role as a key gas and gas technology provider. The second layer represents near term options and possibilities with a reasonable risk profile that could further enhance the Norwegian position given the resources and drive to further develop this industry. As the top layer we have selected some of our 'dreams', what we may achieve if a progressive approach is followed with a strongly innovation based policy. It is acknowledged by the TTA that Norway cannot be a leading technology player in all aspects of the gas value chain. For some technologies we should be an active player and developer, whilst for other technologies we should become a competent buyer and user. This

Technology strategy for gas technologies; Technology Target Areas; TTA8 Gas Technology

Energy Technology Data Exchange (ETDEWEB)

2008-07-01

TTA8 - Gas technologies points out the various routes Norway can follow to capitalise on the vast resources of natural gas that will be produced in the years to come by developing a strong technology and competence platform. A broad view is taken for the value creation having as basis the continued gas export from NCS to Europe, but also a strong focus on development of gas resources in other parts of the world. The latter can also be seen as part of international positioning for upstream resources and does also include involvements in projects, and export of technology and products. The TTA has structured the analysis into 3 main areas: Gas transport and processing (pipeline, LNG, other); Gas conversion to fuels, chemicals and materials; CO{sub 2} management. In this report, for each of these areas, scenarios based on a gap analysis are presented. One of the key goals has been to identify pacing and emerging technologies for the next 20 years. Based on this, technologies have been mapped according to importance for future competitiveness and technology ambitions. This also includes primary funding responsibilities (public and/or industry). The road map below reflects the key issues in the proposed strategy. The base level of the figure explains areas that will have to be pursued to maintain Norway's role as a key gas and gas technology provider. The second layer represents near term options and possibilities with a reasonable risk profile that could further enhance the Norwegian position given the resources and drive to further develop this industry. As the top layer we have selected some of our 'dreams', what we may achieve if a progressive approach is followed with a strongly innovation based policy. It is acknowledged by the TTA that Norway cannot be a leading technology player in all aspects of the gas value chain. For some technologies we should be an active player and developer, whilst for other technologies we should become a competent buyer

Advances in Targeted Pesticides with Environmentally Responsive Controlled Release by Nanotechnology

Directory of Open Access Journals (Sweden)

Bingna Huang

2018-02-01

Full Text Available Pesticides are the basis for defending against major biological disasters and important for ensuring national food security. Biocompatible, biodegradable, intelligent, and responsive materials are currently an emerging area of interest in the field of efficient, safe, and green pesticide formulation. Using nanotechnology to design and prepare targeted pesticides with environmentally responsive controlled release via compound and chemical modifications has also shown great potential in creating novel formulations. In this review, special attention has been paid to intelligent pesticides with precise controlled release modes that can respond to micro-ecological environment changes such as light-sensitivity, thermo-sensitivity, humidity sensitivity, soil pH, and enzyme activity. Moreover, establishing intelligent and controlled pesticide release technologies using nanomaterials are reported. These technologies could increase pesticide-loading, improve the dispersibility and stability of active ingredients, and promote target ability.

Database created with the operation of environmental monitoring program from the Nuclear Technology Development Center (CDTN) - Brazilian CNEN

International Nuclear Information System (INIS)

Peixoto, C.M.

1995-01-01

The environmental control from the Nuclear Technology Development Center (CDTN - Brazilian CNEN) is done through a Program of Environmental Monitoring-PMA, which has been in operation since 1985. To register all the analytic results of the several samples, samples, a database was created. In this work, this database structure as well as the information used in the evaluation of the results obtained from the operation of the above-mentioned PMA are presented. (author). 5 refs, 1 fig, 3 tabs

Method for Targeted Therapeutic Delivery of Proteins into Cells | NCI Technology Transfer Center | TTC

Science.gov (United States)

The Protein Expression Laboratory at the National Cancer Institute in Frederick, MD is seeking statements of capability or interest from parties interested in collaborative research to further develop a platform technology for the targeted intra-cellular delivery of proteins using virus-like particles (VLPs).

Targeted Prostate Biopsy: Lessons Learned Midst the Evolution of a Disruptive Technology.

Science.gov (United States)

Nassiri, Nima; Natarajan, Shyam; Margolis, Daniel J; Marks, Leonard S

2015-09-01

Lessons learned during a 6-year experience with more than 1200 patients undergoing targeted prostate biopsy via MRI/ultrasound fusion are reported: (1) the procedure is safe and efficient, requiring some 15-20 minutes in an office setting; (2) MRI is best performed by a radiologist with specialized training, using a transabdominal multiparametric approach and preferably a 3T magnet; (3) grade of MRI suspicion is the most powerful predictor of biopsy results, eg, Grade 5 usually represents cancer; (4) some potentially important cancers (15%-30%) are MRI-invisible; (5) Targeted biopsies provide >80% concordance with whole-organ pathology. Early enthusiasm notwithstanding, cost-effectiveness is yet to be resolved, and the technologies remain in evolution. Copyright © 2015 Elsevier Inc. All rights reserved.

Coping with Atmospheric Turbulence in the Selection of Laser Hardening Technology for FCS Targeting Systems

National Research Council Canada - National Science Library

Pritchett, Timothy M

2004-01-01

... by frequency-agile battlefield lasers at both long and short range. Evidently, the selection of sensor protection technologies for incorporation into the final targeting system will be based on their optical limiting performance under field conditions...

Teamwork and technology: Success factors for creating growth

International Nuclear Information System (INIS)

1998-01-01

The petroleum industry faces many challenges moving toward the next century. How effectively these challenges are addressed and managed will determine whether or not the exploration and production business grows and prospers in the future. This presentation relates to success factors for growth creation. Themes discussed here are succeeding in a global energy market, evolution of relationships between oil and gas companies and service companies, the power of technology, and effectively combining teamwork and technology

Thermal analysis of LEU modified Cintichem target irradiated in TRIGA reactor

International Nuclear Information System (INIS)

Catana, A; Toma, C.

2009-01-01

Actions conceived during last years at international level for conversion of Molybdenum fabrication process from HEU to LEU targets utilization created opportunities for INR to get access to information and participating to international discussions under IAEA auspices. Concrete steps for developing fission Molybdenum technology were facilitated. Institute of Nuclear Research bringing together a number of conditions like suitable irradiation possibilities, direct communication between reactor and hot cell facility, handling capacity of high radioactive sources, and simultaneously the existence of an expanding internal market, decided to undertake the necessary steps in order to produce fission molybdenum. Over the course of last years of efforts in this direction we developed the steps for fission Molybdenum technology development based on modified Cintichem process in accordance with the Argonne National Laboratory proved methodology. Progress made by INR to heat transfer computations of annular target using is presented. An advanced thermal-hydraulic analysis was performed to estimate the heat removal capability for an enriched uranium (LEU) foil annular target irradiated in TRIGA reactor core. As a result, the present analysis provides an upper limit estimate of the LEU-foil and external target surface temperatures during irradiation in TRIGA 14 MW reactor. (authors)

The development of uranium foil farication technology utilizing twin roll method for Mo-99 irradiation target

CERN Document Server

Kim, C K; Park, H D

2002-01-01

MDS Nordion in Canada, occupying about 75% of global supply of Mo-99 isotope, has provided the irradiation target of Mo-99 using the rod-type UAl sub x alloys with HEU(High Enrichment Uranium). ANL (Argonne National Laboratory) through co-operation with BATAN in Indonesia, leading RERTR (Reduced Enrichment for Research and Test Reactors) program substantially for nuclear non-proliferation, has designed and fabricated the annular cylinder of uranium targets, and successfully performed irradiation test, in order to develop the fabrication technology of fission Mo-99 using LEU(Low Enrichment Uranium). As the uranium foils could be fabricated in laboratory scale, not in commercialized scale by hot rolling method due to significant problems in foil quality, productivity and economic efficiency, attention has shifted to the development of new technology. Under these circumstances, the invention of uranium foil fabrication technology utilizing twin-roll casting method in KAERI is found to be able to fabricate LEU or...

The CRISPR-Cas9 technology: Closer to the ultimate toolkit for targeted genome editing.

Science.gov (United States)

Quétier, Francis

2016-01-01

The first period of plant genome editing was based on Agrobacterium; chemical mutagenesis by EMS (ethyl methanesulfonate) and ionizing radiations; each of these technologies led to randomly distributed genome modifications. The second period is associated with the discoveries of homing and meganuclease enzymes during the 80s and 90s, which were then engineered to provide efficient tools for targeted editing. From 2006 to 2012, a few crop plants were successfully and precisely modified using zinc-finger nucleases. A third wave of improvement in genome editing, which led to a dramatic decrease in off-target events, was achieved in 2009-2011 with the TALEN technology. The latest revolution surfaced in 2013 with the CRISPR-Cas9 system, whose high efficiency and technical ease of use is really impressive; scientists can use in-house kits or commercially available kits; the only two requirements are to carefully choose the location of the DNA double strand breaks to be induced and then to order an oligonucleotide. While this close-to- ultimate toolkit for targeted editing of genomes represents dramatic scientific progress which allows the development of more complex useful agronomic traits through synthetic biology, the social acceptance of genome editing remains regularly questioned by anti-GMO citizens and organizations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Research and development project for a large-scale industrial technology in fiscal 1992. Research and development of an advanced function creating and processing technology /Development of an advanced function creating and processing technology (Report on work achievements); 1992 nend senshin kino soshutsu kako gijutsu no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-01-01

A joint research has been performed between the Material Engineering Technology Research Institute of the National Institute of Materials and Chemical Research of the Ministry of International Trade and Industry and the Advanced Function Creating and Processing Technology Research Association. The research themes are the 'identification of the basic conditions for production of ultra fine ceramics particles by using the hybrid high-frequency plasma process' and the 'establishment of non-destructive analysis technology for inclination functional materials'. This paper reports the achievements in fiscal 1992. The research on the inclination functional materials has performed hybridization of high-frequency plasmas and fabrication of ultra fine alumina particles, trial fabrication and evaluation on alumina-titanium mixed ultra fine particles by using the high-frequency plasma process, spraying of hydroxyapatite by using high-frequency plasma, evaluation on thick film bulk made of ultra fine particles, and trial fabrication of an ultra fine particle injection device. It was intended to evaluate quantitatively crystalline deficiency and composition distribution in the inclination functional materials for which continuous composition control is important. Therefore, a Rutherford wake scattering device was introduced and installed newly at the Material Engineering Technology Research Institute, which has improved the evaluation and experiment system at the institute. (NEDO)

Technology strategy for subsea processing and transport; Technology Target Areas; TTA6 - Subsea processing and transportation

Energy Technology Data Exchange (ETDEWEB)

2008-07-01

OG21 (www.OG21.org) Norway's official technology strategy for the petroleum sector issued a revised strategy document in November 2005 (new strategy planned in 2009). In this document 'Subsea processing and transport' was identified as one of the eight new technology target areas (TTAs). The overall OG21 strategy document is on an aggregated level, and therefore the Board of OG21 decided that a sub-strategy for each TTA was needed. This document proposes the sub-strategy for the technology target area 'Subsea processing and transport' which covers the technology and competence necessary to effectively transport well stream to a platform or to onshore facilities. This includes multiphase flow modelling, flow assurance challenges to avoid problems with hydrates, asphaltenes and wax, subsea or downhole fluid conditioning including bulk water removal, and optionally complete water removal, and sand handling. It also covers technologies to increase recovery by pressure boosting from subsea pumping and/or subsea compression. Finally it covers technologies to facilitate subsea processing such as control systems and power supply. The vision of the Subsea processing and transport TTA is: Norway is to be the leading international knowledge- and technology cluster in subsea processing and transport: Sustain increased recovery and accelerated production on the NCS by applying subsea processing and efficient transport solutions; Enable >500 km gas/condensate multiphase well stream transport; Enable >200 km oil-dominated multiphase well stream transport; Enable well stream transport of complex fluids; Enable subsea separation, boosting compression, and water injection; Enable deepwater developments; Enable environmentally friendly and energy efficient field development. Increase the export of subsea processing and transport technology: Optimize technology from the NCS for application worldwide; Develop new technology that can meet the challenges found in

Creating a Pilot Educational Psychiatry Website: Opportunities, Barriers, and Next Steps.

Science.gov (United States)

Torous, John; O'Connor, Ryan; Franzen, Jamie; Snow, Caitlin; Boland, Robert; Kitts, Robert

2015-11-05

While medical students and residents may be utilizing websites as online learning resources, medical trainees and educators now have the opportunity to create such educational websites and digital tools on their own. However, the process and theory of building educational websites for medical education have not yet been fully explored. To understand the opportunities, barriers, and process of creating a novel medical educational website. We created a pilot psychiatric educational website to better understand the options, opportunities, challenges, and processes involved in the creation of a psychiatric educational website. We sought to integrate visual and interactive Web design elements to underscore the potential of such Web technology. A pilot website (PsychOnCall) was created to demonstrate the potential of Web technology in medical and psychiatric education. Creating an educational website is now technically easier than ever before, and the primary challenge no longer is technology but rather the creation, validation, and maintenance of information for such websites as well as translating text-based didactics into visual and interactive tools. Medical educators can influence the design and implementation of online educational resources through creating their own websites and engaging medical students and residents in the process.

Micro-CHP Technologies Roadmap: Meeting 21st Century Residential Energy Needs

Energy Technology Data Exchange (ETDEWEB)

none,

2003-12-01

On June 11-12, 2003, at Greenbelt, Maryland, key stakeholders from industry, government agencies, universities, and others involved in combined heat and power and the residential buildings industry explores solutions to technical, institutional, and market barriers facing micro-combined heat and power systems (mCHP). Participants outlined a desired future for mCHP systems, identified specific interim technology cost and performance targets, and developed actions to achieve the interim targets and vision. This document, The Micro-CHP Technologies Roadmap, is a result of their deliberations. It outlines a set of actions that can be pursued by both the government and industry to develop mCHP appliances for creating a new approach for households to meet their energy needs.

Studying the Technology of Creating Cortical Electrode Instruments using the Rapid Prototyping Technology

Directory of Open Access Journals (Sweden)

Ablyaz T. R.

2017-06-01

Full Text Available This paper shows the results of studying the technology of manufacturing cortical electrode-instruments (EI with the use of indirect methods of the Rapid Prototyping technology. Functional EI prototypes were made by layered synthesis of the photopolymer material with the use of the stereolithography technology (SLA - Stereo Lithography Apparatus. The article is focused on two methods of indirect EI manufacturing. One of the EI prototypes was used for making a molded wax model for hot investment casting, followed by applying copper coating. The second prototype was used for applying copper plating to a prepared current-conductive layer. As a result of EDMing a steel workpiece, both EIs reached the desired depth, which is 1 mm. The copper plating applied to the EI preserves its integrity. Through the use of the casting technology, there is a possibility to cut the economic costs by 35%. Using a prototype with preliminarily applied conductive coating makes it possible to make geometrically-complex EIs.

Creating and Diffusing a Technology Champion Course

Science.gov (United States)

Granitz, Neil; Hugstad, Paul

2004-01-01

Excitement has been generated for using Internet technology as a vehicle to further numerous educational objectives, including enhanced student learning, greater integration of business school functional areas, and increased job market relevance. This article discusses how the Introductory Internet Marketing course can be positioned as a…

Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

DEFF Research Database (Denmark)

Olsen, Louise Cathrine Braun; Færgeman, Nils J.

2012-01-01

and validate therapeutic targets and to discover drug candidates for rapidly and effectively generating new interventions for human diseases. The recent emergence of genomic technologies and their application on genetically tractable model organisms like Drosophila melanogaster,Caenorhabditis elegans...... critical roles in the genomic age of biological research and drug discovery. In the present review we discuss how simple biological model organisms can be used as screening platforms in combination with emerging genomic technologies to advance the identification of potential drugs and their molecular...

Can technology adoption for older adults be co-created?

DEFF Research Database (Denmark)

Lu, Yuan; Valk, Carlijn; Steenbakkers, Jim

2017-01-01

-creation ideation process can contribute to the technology adoption of older adults conducted in an EU project with multi-stakeholder teams with the aim of promoting physical activities of older adult citizens. This ideation process is adapted from Method A. By analyzing the co-creation ideation process from three......Technology can be very valuable to support older adults to remain healthy and active in their daily living. How to design technological product and service systems that will be adopted by older adults however still remains a challenge. This paper reports on an empirical study on how a co...

Creating load for new hydrogen production

International Nuclear Information System (INIS)

Smith, R.

2006-01-01

This presentation provides an update of the activities of the Hydrogen Village. The Hydrogen Village is a public-private partnership of approximately 40 companies with the goal of advancing awareness of the environmental, economic and social benefits of hydrogen and fuel cell technologies. The intent of the hydrogen village is to create a sustainable commercial market for these technologies within the Greater Toronto Area and to help to catalyze such markets in other areas

Laser coupling to reduced-scale targets at NIF Early Light

International Nuclear Information System (INIS)

Hinkel, D E; Schneider, M B; Young, B K; Holder, J P; Langdon, A B; Baldis, H A; Bonanno, G; Bower, D E; Bruns, H C; Campbell, K M; Celeste, J R; Compton, S; Costa, R L; Dewald, E L; Dixit, S N; Eckart, M J; Eder, D C; Edwards, M J; Ellis, A D; Emig, J A; Froula, D H; Glenzer, S H; Hargrove, D; Haynam, C A; Heeter, R F; Henesian, M A; Holtmeier, G; James, D L; Jancaitis, K S; Kalantar, D H; Kamperschroer, J H; Kauffman, R L; Kimbrough, J; Kirkwood, R K; Koniges, A E; Landen, O L; Landon, M; Lee, F D; MacGowan, B J; Mackinnon, A J; Manes, K R; Marshall, C; May, M J; McDonald, J W; Menapace, J; Moses, S I; Munro, D H; Murray, J R; Niemann, C; Pellinen, D; Power, G D; Rekow, V; Ruppe, J A; Schein, J; Shepherd, R; Singh, M S; Springer, P; Still, C H; Suter, L J; Tietbohl, G L; Turner, R E; VanWonterghem, B M; Wallace, R J; Warrick, A; Watts, P; Weber, F; Wegner, P J; Williams, E A; Young, P E

2005-01-01

Deposition of maximum laser energy into a small, high-Z enclosure in a short laser pulse creates a hot environment. Such targets were recently included in an experimental campaign using the first four of the 192 beams of the National Ignition Facility [J. A. Paisner, E. M. Campbell, and W. J. Hogan, Fusion Technology 26 26, 755 (1994)], under construction at the University of California Lawrence Livermore National Laboratory. These targets demonstrate good laser coupling, reaching a radiation temperature of 340 eV. In addition, the Raman backscatter spectrum contains features consistent with Brillouin backscatter of Raman forward scatter [A. B. Langdon and D. E. Hinkel, Physical Review Letters 89, 015003 (2002)]. Also, NIF Early Light diagnostics indicate that 20% of the direct backscatter from these reduced-scale targets is in the polarization orthogonal to that of the incident light

Creating technological boundaries to protect bedtime: examining work-home boundary management, psychological detachment and sleep.

Science.gov (United States)

Barber, Larissa K; Jenkins, Jade S

2014-08-01

This study examined the mechanism by which information and communication technology (ICT) use at home for work purposes may affect sleep. In this investigation, data from 315 employees were used to examine the indirect effect of ICT use at home on sleep outcomes through psychological detachment, and how boundary creation may moderate this effect. Results revealed the indirect effect of increased work-home boundary crossing on sleep (quantity, quality and consistency) through psychological detachment occurred only among individuals with low boundaries around ICT use and not among those with high boundaries. These results suggest that creating boundaries around work-relevant ICT use while at home is beneficial to sleep as a recovery process through being able to psychologically disengage from work. Copyright © 2013 John Wiley & Sons, Ltd.

Can technology adoption for older adults be co-created?

NARCIS (Netherlands)

Lu, Y.; Valk, C.A.L.; Steenbakkers, J.J.H.; Bekker, M.M.; Visser, T.; Proctor, G.M.; Toshniwal, O.; Langberg, H.

2017-01-01

Technology can be very valuable to support older adults to remain healthy and active in their daily living. How to design technological product and service systems that will be adopted by older adults however still remains a challenge. This paper reports on an empirical study on how a co-creation

CREATING DIGITAL ELEVATION MODEL USING A MOBILE DEVICE

Directory of Open Access Journals (Sweden)

A. İ. Durmaz

2017-11-01

Full Text Available DEM (Digital Elevation Models is the best way to interpret topography on the ground. In recent years, lidar technology allows to create more accurate elevation models. However, the problem is this technology is not common all over the world. Also if Lidar data are not provided by government agencies freely, people have to pay lots of money to reach these point clouds. In this article, we will discuss how we can create digital elevation model from less accurate mobile devices’ GPS data. Moreover, we will evaluate these data on the same mobile device which we collected data to reduce cost of this modeling.

The Time Is Now! Creating Technology Competencies for Teacher Educators

Science.gov (United States)

Foulger, Teresa S.; Graziano, Kevin J.; Slykhuis, David; Schmidt-Crawford, Denise; Trust, Torrey

2016-01-01

The way preservice teachers learn to use technology within their practice varies widely depending on the learning opportunities available (e.g., technology-infused teacher preparation program vs. standalone education technology course), and the knowledge, skills, and attitudes of the teacher educators within their teacher preparation programs.…

Learning through Creating Robotic Models of Biological Systems

Science.gov (United States)

Cuperman, Dan; Verner, Igor M.

2013-01-01

This paper considers an approach to studying issues in technology and science, which integrates design and inquiry activities towards creating and exploring technological models of scientific phenomena. We implemented this approach in a context where the learner inquires into a biological phenomenon and develops its representation in the form of a…

Qualitative analysis of plasma created by shock laser

International Nuclear Information System (INIS)

Grevey, D.; Maiffredy, L.; Vannes, A.B.; Gobin, P.F.

1987-01-01

The origin of effects observed of the surface of metals treated by lasers was studied. High speed cinematography (20,000 frames/sec) was used to follow the evolution of plasma shape from start to finish. An Nd glass laser and FeNi targets were used. The irradiated surface was examined using optical and scanning electron-microscopes. The phenomenology of plasma formation, and plasma expansion are summarized. Liquid spattering and concentric waves on the target surface are revealed. Results suggest that the main agent of the effects in laser-target interactions is the plasma, which creates compression waves inside the target. These waves quickly become a shock wave which can modify the microstructure of the target [fr

The Ignition Target for the National Ignition Facility

International Nuclear Information System (INIS)

Atherton, L J; Moses, E I; Carlisle, K; Kilkenny, J

2007-01-01

The National Ignition Facility (NIF) is a 192 beam Nd-glass laser facility presently under construction at Lawrence Livermore National Laboratory (LLNL) for performing inertial confinement fusion (ICF) and experiments studying high energy density (HED) science. When completed in 2009, NIF will be able to produce 1.8 MJ, 500 TW of ultraviolet light for target experiments that will create conditions of extreme temperatures (>10 8 K), pressures (10-GBar) and matter densities (> 100 g/cm 3 ). A detailed program called the National Ignition Campaign (NIC) has been developed to enable ignition experiments in 2010, with the goal of producing fusion ignition and burn of a deuterium-tritium (DT) fuel mixture in millimeter-scale target capsules. The first of the target experiments leading up to these ignition shots will begin in 2008. Targets for the National Ignition Campaign are both complex and precise, and are extraordinarily demanding in materials fabrication, machining, assembly, cryogenics and characterization. An overview of the campaign for ignition will be presented, along with technologies for target fabrication, assembly and metrology and advances in growth and x-ray imaging of DT ice layers. The sum of these efforts represents a quantum leap in target precision, characterization, manufacturing rate and flexibility over current state-of-the-art

OHVT Technology Roadmap

Energy Technology Data Exchange (ETDEWEB)

Bradley, R.A.

2001-10-22

The U.S. Department of Energy (DOE) Office of Heavy Vehicle Technologies (OHVT) was created in March 1996 to address the public-interest transportation-energy aspects of a set of customers who at that time had been largely unrecognized, namely, the manufacturers, suppliers, and users of heavy transport vehicles (trucks, buses, rail, and inland marine). Previously, the DOE had focused its attention on meeting the needs of the personal-transport-vehicle customer (automobile manufacturers, suppliers, and users). Those of us who were of driving age at the time of the 1973 oil embargo and the 1979 oil price escalation vividly recall the inconvenience and irritation of having to wait in long lines for gasoline to fuel our cars. However, most of us, other than professional truck owners or drivers, were unaware of the impacts that these disruptions in the fuel supply had on those whose livelihoods depend upon the transport of goods. Recognizing the importance of heavy vehicles to the national economic health, the DOE created OHVT with a mission to conduct, in collaboration with its industry partners and their suppliers, a customer-focused national program to research and develop technologies that will enable trucks and other heavy vehicles to be more energy-efficient and able to use alternative fuels while reducing emissions. The Office of Heavy Vehicle Technologies convened a workshop in April 1996 to elicit input from DOE's heavy vehicle industry customers, including truck and bus manufacturers, diesel-engine manufacturers, fuel producers, suppliers to these industries, and the trucking industry. The preparation of a ''technology roadmap'' was one of the key recommendations by this customer group. Therefore, the OHVT Technology Roadmap* was developed in 1996 as a first step in crafting a common vision for a government research and development (R and D) partnership in this increasingly important transportation sector. The approach used in

Gene targeting using homologous recombination in embryonic stem cells: The future for behavior genetics?

Directory of Open Access Journals (Sweden)

Robert eGerlai

2016-04-01

Full Text Available Gene targeting with homologous recombination in embryonic stem cells created a revolution in the analysis of the function of genes in behavioral brain research. The technology allowed unprecedented precision with which one could manipulate genes and study the effect of this manipulation on the central nervous system. With gene targeting, the uncertainty inherent in psychopharmacology regarding whether a particular compound would act only through a specific target was removed. Thus, gene targeting became highly popular. However, with this popularity came the realization that like other methods, gene targeting also suffered from some technical and principal problems. For example, two decades ago, issues about compensatory changes and about genetic linkage were raised. Since then, the technology developed, and its utility has been better delineated. This review will discuss the pros and cons of the technique along with these advancements from the perspective of the neuroscientist user. It will also compare and contrast methods that may represent novel alternatives to the homologous recombination based gene targeting approach, including the TALEN and the CRISPR/Cas9 systems. The goal of the review is not to provide detailed recipes, but to attempt to present a short summary of these approaches a behavioral geneticist or neuroscientist may consider for the analysis of brain function and behavior.

Creating With Carbon

Science.gov (United States)

2003-01-01

A subsidiary of SI Diamond Technology, Inc., Applied Nanotech, of Austin, Texas, is creating a buzz among various technology firms and venture capital groups interested in the company s progressive research on carbon-related field emission devices, including carbon nanotubes, filaments of pure carbon less than one ten-thousandth the width of human hair. Since their discovery in 1991, carbon nanotubes have gained considerable attention due to their unique physical properties. For example, a single perfect carbon nanotube can range from 10 to 100 times stronger than steel, per unit weight. Recent studies also indicate that the nanotubes may be the best heat-conducting material in existence. These properties, combined with the ease of growing thin films or nanotubes by a variety of deposition techniques, make the carbon-based material one of the most desirable for cold field emission cathodes.

Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology.

Science.gov (United States)

Xia, Chun-Fang; Zhang, Yufeng; Zhang, Yun; Boado, Ruben J; Pardridge, William M

2007-12-01

The effective delivery of short interfering RNA (siRNA) to brain following intravenous administration requires the development of a delivery system for transport of the siRNA across the brain capillary endothelial wall, which forms the blood-brain barrier in vivo. siRNA was delivered to brain in vivo with the combined use of a receptor-specific monoclonal antibody delivery system, and avidin-biotin technology. The siRNA was mono-biotinylated on either terminus of the sense strand, in parallel with the production of a conjugate of the targeting MAb and streptavidin. Rat glial cells (C6 or RG-2) were permanently transfected with the luciferase gene, and implanted in the brain of adult rats. Following the formation of intra-cranial tumors, the rats were treated with a single intravenous injection of 270 microg/kg of biotinylated siRNA attached to a transferrin receptor antibody via a biotin-streptavidin linker. The intravenous administration of the siRNA caused a 69-81% decrease in luciferase gene expression in the intracranial brain cancer in vivo. Brain delivery of siRNA following intravenous administration is possible with siRNAs that are targeted to brain with the combined use of receptor specific antibody delivery systems and avidin-biotin technology.

Target validation for FCV technology development in Japan from energy competition point of view

International Nuclear Information System (INIS)

ENDO Eiichi

2006-01-01

The objective of this work is to validate the technical targets in the governmental hydrogen energy road-map of Japan by analyzing market penetration of fuel cell vehicle(FCV)s and effects of fuel price and carbon tax on it from technology competition point of view. In this analysis, an energy system model of Japan based on MARKAL is used. The results of the analysis show that hydrogen FCVs could not have cost-competitiveness until 2030 without carbon tax, including the governmental actual plan of carbon tax. However, as the carbon tax rate increases, instead of conventional vehicles including gasoline hybrid electric vehicle, hydrogen FCVs penetrate to the market earlier and more. By assuming higher fuel price and severer carbon tax rate, market share of hydrogen FCVs approaches to the governmental goal. This suggests that cheaper vehicle cost and/or hydrogen price than those targeted in the road-map is required. At the same time, achievement of the technical targets in the road-map also allows to attain the market penetration target of hydrogen FCVs in some possible conditions. (authors)

[Optimization study on extraction technology of the seed of Ziziphus jujuba var. spinosa by orthogonal design with multi-targets].

Science.gov (United States)

Wang, Xiao-liang; Zhang, Yu-jie; Chen, Ming-xia; Wang, Ze-feng

2005-05-01

To optimize extraction technology of the seed of Ziziphus jujuba var. spinosa with the targets of the total saponin, total jujuboside A and B and total flavonoids. In the method of one-way and orthogonal tests, ethanol concentration, amount of ethanol, extraction time and extraction times were the factors in orthogonal test, and each factor with three levels. Ethanol concentration and extraction times had significant effect on all the targets, other factors should be selected in accordance with production practice. The best extraction technology is to extract for three times with 8 fold ethanol solution (60%), and 1.5 h each time.

Creating Intangible Value through a Corporate Employee Portal

OpenAIRE

David Mendes; Jorge Gomes; Mário Romao

2017-01-01

Organizations create competitive advantage by creating more economic value than their rivals. Increasing business competition and information technology development have both led to huge corporate organizational changes and have raised the importance of intangible assets along the value chain. Value creation and the success of organizations increasingly depends on the leverage of knowledge available internally, as nowadays it has become essential to understand employee portals’ business value...

Practice management companies. Creating sound information technology strategies.

Science.gov (United States)

Cross, M A

1997-10-01

Practice management companies are becoming more prominent players in the health care industry. To improve the performance of the group practices that they acquire, these companies are striving to use updated information technologies.

Convection in molten pool created by a concentrated energy flux on a solid metal target

International Nuclear Information System (INIS)

Dikshit, B.; Zende, G. R.; Bhatia, M. S.; Suri, B. M.

2009-01-01

During surface evaporation of metals by use of a concentrated energy flux such as electron beam or lasers, a liquid metal pool having a very high temperature gradient is formed around the hot zone created by the beam. Due to temperature dependence of surface tension, density, and depression of the evaporating surface caused by back pressure of the emitted vapor in this molten pool, a strong convective current sets in the molten pool. A proposition is made that this convection may pass through three different stages during increase in the electron beam power depending upon dominance of the various driving forces. To confirm this, convective heat transfer is quantified in terms of dimensionless Nusselt number and its evolution with power is studied in an experiment using aluminum, copper, and zirconium as targets. These experimentally determined values are also compared to the theoretical values predicted by earlier researchers to test the validity of their assumptions and to know about the type of flow in the melt pool. Thus, conclusion about the physical characteristics of flow in the molten pool of metals could be drawn by considering the roles of surface tension and curvature of the evaporating surface on the evolution of convective heat transfer.

2010 national progress report on R and D on LEU fuel and target technology in Argentina

International Nuclear Information System (INIS)

Balart, S.; Blaumann, H.; Cristini, P.; Gonzalez, A.G.; Gonzalez, R.; Hermida, J.D.; Lopez, M.; Mirandou, M.; Taboada, H.

2010-01-01

Since last RRFM meeting, CNEA has deployed several related tasks. The RA-6 MTR type reactor, converted its core from HEU to a new LEU silicide one is scaling up the power, according to a protocol requested by the national regulatory body, ARN. CNEA is deploying an intense R and D activity to fabricate both dispersed U-Mo (Al-Si matrix and Al cladding) and monolithic (Zry-4 cladding) miniplates to develop possible solutions to VHD dispersed and monolithic fuels technical problems. Some monolithic 58% enrichment U8%Mo and U10%Mo are being delivered to INL-DoE to be irradiated in ATR reactor core. A conscientious study on compound interphase formation in both cases is being carried out. CNEA, a worldwide leader on LEU technology for fission radioisotope production is providing Brazil with these radiopharmaceutical products and Egypt and Australia with the technology through INVAP SE. CNEA is also committed to improve the diffusion of LEU target and radiochemical technology for radioisotope production and target and process optimization. Future plans include: 1) Fabrication of a LEU dispersed U-Mo fuel prototype following the recommendations of the IAEA's Good Practices document, to be irradiated in a high flux reactor in the frame of the ARG/4/092 IAEA's Technical Cooperation project. 2) Development of LEU very high density monolithic and dispersed U-Mo fuel plates with Zry-4 or Al cladding as a part of the RERTR program. 3) Optimization of LEU target and radiochemical techniques for radioisotope production. (author)

The Impact of a Technology Coordinator's Belief System upon Using Technology to Create a Community's History

Science.gov (United States)

Waring, Scott M.

2010-01-01

As it has been shown that teachers of social studies content are less likely than teachers of other content areas to utilize technology in their classroom, this study focuses on one instructional technology coordinators' beliefs towards technology, instruction, and students and how these beliefs impacted how technology was utilized during a…

Laser Technology.

Science.gov (United States)

Gauger, Robert

1993-01-01

Describes lasers and indicates that learning about laser technology and creating laser technology activities are among the teacher enhancement processes needed to strengthen technology education. (JOW)

Creating Educational Technology Curricula for Advanced Studies in Learning Technology

Directory of Open Access Journals (Sweden)

Minoru Nakayama

2016-08-01

Full Text Available Curriculum design and content are key factors in the area of human resource development. To examine the possibility of using a collaboration of Human Computer Interaction (HCI and Educational Technology (ET to develop innovative improvements to the education system, the curricula of these two areas of study were lexically analyzed and compared. As a further example, the curriculum of a joint course in HCI and ET was also lexically analyzed and the contents were examined. These analyses can be used as references in the development of human resources for use in advanced learning environments.

Target Glint Suppression Technology.

Science.gov (United States)

1980-09-01

Rayleigh for either horizontal or vertical polarization). 2.1.2 Spatial Characterization. Before the effects of diversity on target detection can be...ncs) dRCS T If the lower intergration limit is taken as zero for the Rayleigh targct model of interest, then this quantity is unbounded. In...port wing, inner section Trailing edge of starboard .:ing, inner section Leading edge of horizontal stabilizer, inner section, port side TLeal, -g

Self-enhancement learning: target-creating learning and its application to self-organizing maps.

Science.gov (United States)

Kamimura, Ryotaro

2011-05-01

In this article, we propose a new learning method called "self-enhancement learning." In this method, targets for learning are not given from the outside, but they can be spontaneously created within a neural network. To realize the method, we consider a neural network with two different states, namely, an enhanced and a relaxed state. The enhanced state is one in which the network responds very selectively to input patterns, while in the relaxed state, the network responds almost equally to input patterns. The gap between the two states can be reduced by minimizing the Kullback-Leibler divergence between the two states with free energy. To demonstrate the effectiveness of this method, we applied self-enhancement learning to the self-organizing maps, or SOM, in which lateral interactions were added to an enhanced state. We applied the method to the well-known Iris, wine, housing and cancer machine learning database problems. In addition, we applied the method to real-life data, a student survey. Experimental results showed that the U-matrices obtained were similar to those produced by the conventional SOM. Class boundaries were made clearer in the housing and cancer data. For all the data, except for the cancer data, better performance could be obtained in terms of quantitative and topological errors. In addition, we could see that the trustworthiness and continuity, referring to the quality of neighborhood preservation, could be improved by the self-enhancement learning. Finally, we used modern dimensionality reduction methods and compared their results with those obtained by the self-enhancement learning. The results obtained by the self-enhancement were not superior to but comparable with those obtained by the modern dimensionality reduction methods.

Creating by Reusing Learning Design Solutions

NARCIS (Netherlands)

Hernández-Leo, Davinia; Harrer, Andreas; Dodero, Juan Manuel; Asensio-Pérez, Juan; Burgos, Daniel

2006-01-01

Hernández-Leo, D., Harrer, A., Dodero, J. M., Asension-Pérez, J. I., & Burgos, D. (2006). Creating by reusing Learning Design solutions. Proceedings of 8th Simposo Internacional de Informática Educativa, León, Spain: IEEE Technical Committee on Learning Technology. Retrieved October 3rd, 2006, from

Technology commercialization: From generating ideas to creating economic value

Directory of Open Access Journals (Sweden)

Tayeb Dehghani

2015-06-01

Full Text Available Frequent changes in competitors' status, technology, and customer interests make it unwise and impossible for companies to rely on their products. Customers always seek to find new products. Consequently, companies should continuously produce and offer superior products to meet customer needs, tastes, and expectations. In fact, every company needs a development plan for its new products. Research has demonstrated that one of the major reasons for rapid development of technology in industrial countries is commercialization of research results. The basis of such commercialization is research-industry collaboration in converting research output into innovation. Today, technology commercialization and its outcomes can provide financial resources required for organizational longevity. The main objective of this article is to propose a model for commercializing research findings from idea generation to initial market entry. We believe that this article can, hopefully, contribute to commercialization literature by acting as a guide to local authorities involved in commercialization cycle.

Role of Bioreactor Technology in Tissue Engineering for Clinical Use and Therapeutic Target Design

Directory of Open Access Journals (Sweden)

Clare Selden

2018-04-01

Full Text Available Micro and small bioreactors are well described for use in bioprocess development in pre-production manufacture, using ultra-scale down and microfluidic methodology. However, the use of bioreactors to understand normal and pathophysiology by definition must be very different, and the constraints of the physiological environment influence such bioreactor design. This review considers the key elements necessary to enable bioreactors to address three main areas associated with biological systems. All entail recreation of the in vivo cell niche as faithfully as possible, so that they may be used to study molecular and cellular changes in normal physiology, with a view to creating tissue-engineered grafts for clinical use; understanding the pathophysiology of disease at the molecular level; defining possible therapeutic targets; and enabling appropriate pharmaceutical testing on a truly representative organoid, thus enabling better drug design, and simultaneously creating the potential to reduce the numbers of animals in research. The premise explored is that not only cellular signalling cues, but also mechano-transduction from mechanical cues, play an important role.

FY 1991 Report on the results of the research and development of the processing technologies for creating advanced functions. Development of the technologies for preventing corrosion of oil production systems; 1991 nendo senshin kino soshutsu kako gijutsu no kenkyu kaihatsu seika hokokusho. Sekiyu seisan system fushoku boshi gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-03-01

The research and development project has been started to develop the technologies for superhigh-purity separation/processing; controlling ultrafine crystal particles, including creating composites by the aid of a plasma laser; synthesizing highly functional organic materials; and supporting these technologies, for creating functions, e.g., advanced sensing functions, highly functional electromagnetic characteristics, and corrosion resistance, heat resistance and high strength. The R and D program for the technologies for superhigh-purity separation/processing covers development of highly corrosion-resistant, high-sensitivity gas sensors and highly functional thin oxide film sensors. The R and D program for controlling ultrafine crystal particles covers the researches on the technologies for creating inclined structures by the ion composite vapor-phase process, and the technologies for producing composites by the aid of a plasma laser. The R and D program for the organic material synthesis technologies includes researches on the technologies for controlling higher structures in a molecular beam composite reaction field, and on the technologies for synthesizing materials in a photon composite reaction field and in an interfacial composite reaction field. The R and D program for the supporting technologies includes the researches on the technologies for diagnosing a composite reaction field by the laser-aided ionization method. In the FY 1991, which is essentially the first year for the project, the efforts are directed to designs and construction of the required facilities, and preliminary tests. (NEDO)

Braking wind in Australia. A critical evaluation of the renewable energy target

International Nuclear Information System (INIS)

Valentine, Scott

2010-01-01

This paper provides a critical evaluation of Australia's new Renewable Energy Target (RET) program with respect to its capacity to support wind power development. Four structural flaws associated with the RET which undermine its effectiveness as a catalyst for technological change in the electricity sector are discussed: (1) the inclusion of waste coal mine gas (WCMG) as an eligible fuel source which acts as an indirect coal industry subsidy, (2) program duration which is too short and ill-structured, (3) a multiplier that is well-intended to support small-scale renewable technologies but which creates 'phantom capacity', and (4) the capped target of 45,000 GWh which will stymie long-term wind power market investment. The paper concludes with recommendations which stress the importance of passing effective Carbon Pollution Renewable Scheme (CPRS) legislation to offset the weaknesses associated with the RET. If an effective CPRS cannot be implemented, the paper recommends that amendments be made to the RET to (1) remove WCMG from the list of approved alternative energy sources, and (2) extend the RET targets to reach 120,000 GWh by 2030. (author)

TARGET - NEW PAYMENT SYSTEM FOR THE EURO AREA

Directory of Open Access Journals (Sweden)

ELENA VIOLETA DRĂGOI

2015-04-01

Full Text Available At EU level, the funds transfer systems have undergone significant changes starting with the introduction of euro. The launch of the euro, the emergence of new technologies, introduction of financial innovations and the globalization have led to reorganization of funds transfer systems` infrastructure. The paper aims to offer an analysis of actual payment system for Euro area, a trans-European funds transfer system with gross settlement in real-time for payments in euro TARGET- to increase economical and operational efficiency of payments and also to reduce the risks in the electronic funds transfer system by creating efficient and secure payment systems.

Feeling validated yet? A scoping review of the use of consumer-targeted wearable and mobile technology to measure and improve sleep.

Science.gov (United States)

Baron, Kelly Glazer; Duffecy, Jennifer; Berendsen, Mark A; Cheung Mason, Ivy; Lattie, Emily G; Manalo, Natalie C

2017-12-20

The objectives of this review were to evaluate the use of consumer-targeted wearable and mobile sleep monitoring technology, identify gaps in the literature and determine the potential for use in behavioral interventions. We undertook a scoping review of studies conducted in adult populations using consumer-targeted wearable technology or mobile devices designed to measure and/or improve sleep. After screening for inclusion/exclusion criteria, data were extracted from the articles by two co-authors. Articles included in the search were using wearable or mobile technology to estimate or evaluate sleep, published in English and conducted in adult populations. Our search returned 3897 articles and 43 met our inclusion criteria. Results indicated that the majority of studies focused on validating technology to measure sleep (n = 23) or were observational studies (n = 10). Few studies were used to identify sleep disorders (n = 2), evaluate response to interventions (n = 3) or deliver interventions (n = 5). In conclusion, the use of consumer-targeted wearable and mobile sleep monitoring technology has largely focused on validation of devices and applications compared with polysomnography (PSG) but opportunities exist for observational research and for delivery of behavioral interventions. Multidisciplinary research is needed to determine the uses of these technologies in interventions as well as the use in more diverse populations including sleep disorders and other patient populations. Copyright © 2017 Elsevier Ltd. All rights reserved.

TARGETED TECHNOLOGY TRANSFER TO US INDEPENDENTS

Energy Technology Data Exchange (ETDEWEB)

Donald F. Duttlinger; E. Lance Cole

2005-01-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of assisting U.S. independent oil and gas producers with timely, informed technology decisions during Fiscal Year 2004 (FY04). PTTC has active grassroots programs through its 10 Regional Lead Organizations (RLOs) and 2 satellite offices. They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, technical publications and other cooperative outreach efforts. PTTC's Headquarters (HQ) staff receives direction from a National Board of Directors predominantly comprised of American natural gas and oil producers to plan and manage the overall technology transfer program. PTTC HQ implements a comprehensive communications program by interconnecting the talents of the National Board, 10 Regional Producer Advisory Groups (PAG) and the RLOs with industry across the U.S. PTTC effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy, namely the Strategic Center for Natural Gas and Oil with state and industry contributions to share application of upstream technologies. Ultimately, these efforts factor in to provide a safe, secure and reliable energy supply for American consumers. This integrated resource base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results regarding domestic production figures. PTTC is increasingly recognized as a critical resource for information and access to technologies by providing direct contact with research, development and demonstration (RD&D) results. A key to the program is demonstrating proven technologies that can be applied broadly and rapidly. This technical progress report summarizes PTTC's accomplishments during

Examining Engineering & Technology Students' Acceptance of Network Virtualization Technology Using the Technology Acceptance Model

Science.gov (United States)

Yousif, Wael K.

2010-01-01

This causal and correlational study was designed to extend the Technology Acceptance Model (TAM) and to test its applicability to Valencia Community College (VCC) Engineering and Technology students as the target user group when investigating the factors influencing their decision to adopt and to utilize VMware as the target technology. In…

Innovation for creating a smart future

Directory of Open Access Journals (Sweden)

Sang M. Lee

2018-01-01

Full Text Available Today, we live in a dynamic and turbulent global community. The wave of mega-trends, including rapid change in globalization and technological advances, is creating new market forces. For any organization to survive and prosper in such an environment, innovation is imperative. However, innovation is no longer just for creating value to benefit individuals, organizations, or societies. The ultimate purpose of innovation should be much more far reaching, helping create a smart future where people can enjoy the best quality of life possible. Thus, innovation must search for intelligent solutions to tackle major social ills, seek more proactive approaches to predict the uncertain future, and pursue strategies to remove barriers to the smart future. This study explores the detailed requirements of a smart future, including both hardware types and soft social/cultural components.

Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

DEFF Research Database (Denmark)

Ronda, Carlotta; Pedersen, Lasse Ebdrup; Hansen, Henning Gram

2014-01-01

of the CRISPR Cas9 technology in CHO cells by generating site-specific gene disruptions in COSMC and FUT8, both of which encode proteins involved in glycosylation. The tested single guide RNAs (sgRNAs) created an indel frequency up to 47.3% in COSMC, while an indel frequency up to 99.7% in FUT8 was achieved...... mutations at the target sites, with a strong preference for single base indels. Finally, we have developed a user-friendly bioinformatics tool, named “CRISPy” for rapid identification of sgRNA target sequences in the CHO-K1 genome. The CRISPy tool identified 1,970,449 CRISPR targets divided into 27...

Science and Technology Test Mining: Disruptive Technology Roadmaps

National Research Council Canada - National Science Library

Kostoff, Ronald

2003-01-01

Disruptive technologies create growth in the industries they penetrate or create entirely new industries through the introduction of products and services that are dramatically cheaper, better, and more convenient...

Research and development project for large industrial technologies in fiscal 1992. Achievement report on research and development of an advanced function creating and processing technology (Development of a technology to prevent corrosion in petroleum production systems); 1992 nendo senshin kino soshutsu kako gijutsu no kenkyu kaihatsu seika hokokusho. Sekiyu seisan system fushoku boshi gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-03-01

In order to enhance durability and safety of members used in ocean bottom petroleum collecting systems, researches were made to create materials having excellent corrosion resistance, strength and heat resistance. In the research of a gas sensor to measure nature of drilled mud water, high corrosion resistance and sensitivity improvement in an infrared gas sensor was attempted through research and development of a high-purity and high-quality film forming technology. In the research of an inclination structure creating technology, researches were made on an interface control technology to enhance adhesion of substrates with ultra fine particle complexes. Developmental research was performed on materials by synthesizing the ultra fine particle complex and by injecting ions into the surface layer. In developing thick ceramics film or bulk having high functions, researches were carried out on a synthesizing technology using compound plasma, and a synthesizing technology using compound laser. In synthesizing high-function organic materials, researches were performed on a high-order structure control technology using the molecular beam compound reaction field, and on a material synthesizing technology using the photon compound reaction field and the interface compound reaction field. A compound reaction field diagnosis technology using the laser ionizing process was studied as a supporting technology. (NEDO)

Captivate MenuBuilder: Creating an Online Tutorial for Teaching Software

Science.gov (United States)

Yelinek, Kathryn; Tarnowski, Lynn; Hannon, Patricia; Oliver, Susan

2008-01-01

In this article, the authors, students in an instructional technology graduate course, describe a process to create an online tutorial for teaching software. They created the tutorial for a cyber school's use. Five tutorial modules were linked together through one menu screen using the MenuBuilder feature in the Adobe Captivate program. The…

Low enrichment Mo-99 target development program at ANSTO

International Nuclear Information System (INIS)

Donlevy, Therese M.; Anderson, Peter J.; Beattie, David; Braddock, Ben; Fulton, Scott; Godfrey, Robert; Law, Russell; McNiven, Scott; Sirkka, Pertti; Storr, Greg; Wassink, David; Wong, Alan; Yeoh, Guan

2002-01-01

The Australian Nuclear Science and Technology Organisation (ANSTO, formerly AAEC) has been producing fission product Mo-99 in HIFAR, from the irradiation of Low Enrichment Uranium (LEU) UO 2 targets, for nearly thirty years. Over this period, the U-235 enrichment has been increased in stages, from natural to 1.8% to 2.2%. The decision to provide Australia with a replacement research reactor (RRR) for HIFAR has created an ideal opportunity to review and improve the current Mo-99 production process from target design through to chemical processing and waste management options. ANSTO has entered into a collaboration with Argonne National Laboratory (RERTR) to develop a target using uranium metal foil with U-235 enrichment of less than 20% The initial focus has been to demonstrate use of LEU foil targets in HIFAR, using existing irradiation methodology. The current effort focussed on designing a target assembly with optimised thermohydraulic characteristics to accommodate larger LEU foils to meet Mo-99 production needs. The ultimate goal is to produce an LEU target suitable for use in the Replacement Research Reactor when it is commissioned in 2005. This paper reports our activities on: - The regulatory approval processes required in order to undertake irradiation of this new target; -Supporting calculations (neutronics, computational fluid dynamics) for safety submission; - Design challenges and changes to prototype irradiation; - Trial irradiation of LEU foil target in HIFAR; - Future target and rig development program at ANSTO. (author)

Engineering Encounters: Creating a Prosthetic Hand

Science.gov (United States)

Cook, Kristin Leigh; Bush, Sarah B.; Cox, Richard

2015-01-01

The power of 3D printing technology has grown exponentially in just the past few years--people around the world are using 3D printers to prepare food, create tailored clothing, build cars and homes, and advance the medical field in ways that never seemed possible. In classrooms across the nation, 3D printers have become increasingly common because…

The first FDA marketing authorizations of next-generation sequencing technology and tests: challenges, solutions and impact for future assays.

Science.gov (United States)

Bijwaard, Karen; Dickey, Jennifer S; Kelm, Kellie; Težak, Živana

2015-01-01

The rapid emergence and clinical translation of novel high-throughput sequencing technologies created a need to clarify the regulatory pathway for the evaluation and authorization of these unique technologies. Recently, the US FDA authorized for marketing four next generation sequencing (NGS)-based diagnostic devices which consisted of two heritable disease-specific assays, library preparation reagents and a NGS platform that are intended for human germline targeted sequencing from whole blood. These first authorizations can serve as a case study in how different types of NGS-based technology are reviewed by the FDA. In this manuscript we describe challenges associated with the evaluation of these novel technologies and provide an overview of what was reviewed. Besides making validated NGS-based devices available for in vitro diagnostic use, these first authorizations create a regulatory path for similar future instruments and assays.

Creating Balance in the New Age of Technology

Science.gov (United States)

Herman, Jana Morgan

2012-01-01

Marc Prensky coined the term "digital native" in 2001 to describe those who have grown up with a constant interaction of technology, including television, video games, and the Internet (Prensky, 2001). For these people, many of them now in their twenties, life has always included the presence of screens--televisions, cell phones, iPods, video…

Creating a Regional Healthcare Network: People First.

Science.gov (United States)

Michel-Verkerke, Margreet B

2016-01-01

Care organizations in the Dutch region Apeldoorn want to collaborate more in order to improve the care provision to elderly and psychiatric patients living independently. In order to support the collaboration they intend to create a regional digital healthcare network. The research was focused on the relevance of a regional healthcare network for care providers. Eleven semi-structured interviews based on the USE IT-model, were conducted with care providers and staff members. Results show that care providers need to tune their activities for this target group and create an agreement on integrated care. The relevance of a digital communication and collaboration platform is high. The regional healthcare network should support the collaboration between care providers by: 1. Offering a communication platform to replace the time consuming communication by telephone; 2. Making patient information available for patient and care provider at patients' homes; 3. Giving insight in who is giving what care to whom; and 4. Giving access to knowledge about the target group: elderly and psychiatric patients living independently.

Creating Micro-Videos to Demonstrate Technology Learning and Digital Literacy

Science.gov (United States)

Frydenberg, Mark; Andone, Diana

2016-01-01

Purpose: Short videos, also known as micro-videos, have emerged as a platform for sharing ideas, experiences and life events via online social networks. This paper aims to share preliminary results of a study, involving students from two universities who created six-second videos using the Vine mobile app to explain or illustrate technological…

From boundaries to boundary work: middle managers creating inter-organizational change.

Science.gov (United States)

Oldenhof, Lieke; Stoopendaal, Annemiek; Putters, Kim

2016-11-21

Purpose In healthcare, organizational boundaries are often viewed as barriers to change. The purpose of this paper is to show how middle managers create inter-organizational change by doing boundary work: the dual act of redrawing boundaries and coordinating work in new ways. Design/methodology/approach Theoretically, the paper draws on the concept of boundary work from Science and Technology Studies. Empirically, the paper is based on an ethnographic investigation of middle managers that participate in a Dutch reform program across health, social care, and housing. Findings The findings show how middle managers create a sense of urgency for inter-organizational change by emphasizing "fragmented" service provision due to professional, sectoral, financial, and geographical boundaries. Rather than eradicating these boundaries, middle managers change the status quo gradually by redrawing composite boundaries. They use boundary objects and a boundary-transcending vocabulary emphasizing the need for societal gains that go beyond production targets of individual organizations. As a result, work is coordinated in new ways in neighborhood teams and professional expertise is being reconfigured. Research limitations/implications Since boundary workers create incremental change, it is necessary to follow their work for a longer period to assess whether boundary work contributes to paradigm change. Practical implications Organizations should pay attention to conditions for boundary work, such as legitimacy of boundary workers and the availability of boundary spaces that function as communities of practice. Originality/value By shifting the focus from boundaries to boundary work, this paper gives valuable insights into "how" boundaries are redrawn and embodied in objects and language.

Advanced hydraulic fracturing methods to create in situ reactive barriers

International Nuclear Information System (INIS)

Murdoch, L.; Siegrist, B.; Vesper, S.

1997-01-01

Many contaminated areas consist of a source area and a plume. In the source area, the contaminant moves vertically downward from a release point through the vadose zone to an underlying saturated region. Where contaminants are organic liquids, NAPL may accumulate on the water table, or it may continue to migrate downward through the saturated region. Early developments of permeable barrier technology have focused on intercepting horizontally moving plumes with vertical structures, such as trenches, filled with reactive material capable of immobilizing or degrading dissolved contaminants. This focus resulted in part from a need to economically treat the potentially large volumes of contaminated water in a plume, and in part from the availability of construction technology to create the vertical structures that could house reactive compounds. Contaminant source areas, however, have thus far remained largely excluded from the application of permeable barrier technology. One reason for this is the lack of conventional construction methods for creating suitable horizontal structures that would place reactive materials in the path of downward-moving contaminants. Methods of hydraulic fracturing have been widely used to create flat-lying to gently dipping layers of granular material in unconsolidated sediments. Most applications thus far have involved filling fractures with coarse-grained sand to create permeable layers that will increase the discharge of wells recovering contaminated water or vapor. However, it is possible to fill fractures with other compounds that alter the chemical composition of the subsurface. One early application involved development and field testing micro-encapsulated sodium percarbonate, a solid compound that releases oxygen and can create aerobic conditions suitable for biodegradation in the subsurface for several months

Advances in point-of-care technologies for molecular diagnostics.

Science.gov (United States)

Zarei, Mohammad

2017-12-15

Advances in miniaturization, nanotechnology, and microfluidics, along with developments in cloud-connected point-of-care (POC) diagnostics technologies are pushing the frontiers of POC devices toward low-cost, user-friendly, and enhanced sensitivity molecular-level diagnostics. The combination of various bio-sensing platforms within smartphone-integrated electronic readers provides accurate on-site and on-time diagnostics based on various types of chemical and biological targets. Further, 3D printing technology shows a huge potential toward fabrication and improving the performance of POC devices. Integration of skin-like flexible sensors with wireless communication technology creates a unique opportunity for continuous, real-time monitoring of patients for both preventative healthcare and during disease outbreaks. Here, we review recent developments and advances in POC technologies and describe how these advances enhance the performance of POC platforms. Also, this review describes challenges, directions, and future trends on application of emerging technologies in POC diagnostics. Copyright © 2017 Elsevier B.V. All rights reserved.

Photocatalytic Solutions Create Self-Cleaning Surfaces

Science.gov (United States)

2013-01-01

A Stennis Space Center researcher investigating the effectiveness of photocatalytic materials for keeping the Center's buildings free of grime turned to a solution created by PURETi Inc. of New York City. Testing proved successful, and NASA and the company now share a Dual Use Technology partnership. PURETi's coatings keep surfaces clean and purify surrounding air, eliminating pollution, odors, and microbes.

Technology is not Enough to Create Connected Cities – Here’s why

DEFF Research Database (Denmark)

Cooray, Mike; Duus, Rikke; Bundgaard, Lasse

2017-01-01

The United Nations (UN) estimates that by 2050, 66% of the world’s population will live in cities. This creates an unprecedented pressure on cities around the world to optimise the standard of living for citizens, organisations and institutions.Cities such as Dubai, Singapore, Yinchuan and Copenh......The United Nations (UN) estimates that by 2050, 66% of the world’s population will live in cities. This creates an unprecedented pressure on cities around the world to optimise the standard of living for citizens, organisations and institutions.Cities such as Dubai, Singapore, Yinchuan...

mRNA Transcript Diversity Creates New Opportunities for Pharmacological Intervention

OpenAIRE

Barrie, Elizabeth S.; Smith, Ryan M.; Sanford, Jonathan C.; Sadee, Wolfgang

2012-01-01

Most protein coding genes generate multiple RNA transcripts through alternative splicing, variable 3′ and 5′UTRs, and RNA editing. Although drug design typically targets the main transcript, alternative transcripts can have profound physiological effects, encoding proteins with distinct functions or regulatory properties. Formation of these alternative transcripts is tissue-selective and context-dependent, creating opportunities for more effective and targeted therapies with reduced adverse e...

INNOVATIVE TECHNOLOGICAL SOLUTIONS IN CREATING FUNCTIONAL PRODUCTS POWER

OpenAIRE

I. V. Sergienko; A. E. Kutsova; S. V. Kutsov

2015-01-01

The article deals with a problem of functional products creation for consumers feeling need in proteins, irreplaceable amino acids, vitamins, mineral substances, food fibers, polynonsaturated fat acids. One of the possible ways to improve human nutrition is using non-traditional cultures for bread making technology containing significant amounts of fibrous substances, easily digestible protein, vitamins, unsaturated fatty acids and minerals. Taking into account the Nutrition Science requireme...

New ultraportable display technology and applications

Science.gov (United States)

Alvelda, Phillip; Lewis, Nancy D.

1998-08-01

MicroDisplay devices are based on a combination of technologies rooted in the extreme integration capability of conventionally fabricated CMOS active-matrix liquid crystal display substrates. Customized diffraction grating and optical distortion correction technology for lens-system compensation allow the elimination of many lenses and systems-level components. The MicroDisplay Corporation's miniature integrated information display technology is rapidly leading to many new defense and commercial applications. There are no moving parts in MicroDisplay substrates, and the fabrication of the color generating gratings, already part of the CMOS circuit fabrication process, is effectively cost and manufacturing process-free. The entire suite of the MicroDisplay Corporation's technologies was devised to create a line of application- specific integrated circuit single-chip display systems with integrated computing, memory, and communication circuitry. Next-generation portable communication, computer, and consumer electronic devices such as truly portable monitor and TV projectors, eyeglass and head mounted displays, pagers and Personal Communication Services hand-sets, and wristwatch-mounted video phones are among the may target commercial markets for MicroDisplay technology. Defense applications range from Maintenance and Repair support, to night-vision systems, to portable projectors for mobile command and control centers.

Status and future application of pilot lead-bismuth target circuit TC-1 for ADS

Energy Technology Data Exchange (ETDEWEB)

Ignatiev, S.; Leonchuk, M.; Orlov, Y.; Pankratov, D.; Reshetnikova, O.; Suvorov, G.; Zabudko, A. [Institute for Physics and Power Engineering, Obninsk (Russian Federation); Stepanov, V.; Klimov, N. [Experimental and Design Organization, Gidropress, Podolsk (Russian Federation); Hechanova, A.; Ma, J. [Nevada Univ., Las Vegas, NV (United States); Li, N. [Los Alamos National Lab., NM (United States); Gudowski, W. [International Science and Technology Center, Moscow (Russian Federation)

2007-07-01

A complicated evolution, status and future application of the pilot molten lead-bismuth target circuit of 1 MW proton beam power (TC-1) as an important part of a target-blanket accelerator driven system (ADS), that has been developed, created and twice tested under the auspice of the International Science and Technology Center (ISTC), is analyzed. The target complex TC-1 is a circulation lead-bismuth loop whose beam window is made of ferritic steel EP-823 (this steel was used in the past as material of fuel rods cladding in reactors cooled with lead-bismuth). At present TC-1 is operating at coolant temperature up to 300 C degrees and will be used to study different issues linked to the use of lead-bismuth: -) interaction with air, water and hydrogen, -) different regimes of flow, -) corrosion, -) filtering, or -) slag formation.

How a Beacon Community Program in New Orleans Helped Create a Better Health Care System by Building Relationships before Technology.

Science.gov (United States)

Khurshid, Anjum; Brown, Lisanne

2014-01-01

In the aftermath of Hurricane Katrina, much of New Orleans' healthcare infrastructure was destroyed. Initial federal funding after the storm expanded primary care services and helped set up medical homes for New Orleans' large uninsured and underinsured population. Following that, the Beacon Community in New Orleans, charged with improving health care through the use of technology, decided the best way to accomplish those goals was to build community partnerships and introduce technology improvements based on their input and on their terms. The purpose of this paper is to describe how those partnerships were wrought, including the innovative use of a conceptual framework, and how they are being sustained; how different technologies were and are being introduced; and what the results have been so far. Past successful community experiences, as well as a proven conceptual framework, were used to help establish community partnerships and governance structures, as well as to demonstrate their linkages. This paper represents a compilation of reports and information from key Beacon leaders, staff and providers and their firsthand experiences in setting up those structures, as well as their conclusions. The community partnerships proved extremely successful in not only devising successful ways to introduce new technology into healthcare settings, but in sustaining those changes by creating a governance structure that has enough fluidity to adapt to changing circumstances. Building and developing community partnerships takes time and effort; however, these relationships are necessary and essential to introducing and sustaining new technologies in a healthcare setting and should be a first step for any organization looking to accomplish such goals.

Overview of the IFE chamber and target technologies R and D in the U.S

International Nuclear Information System (INIS)

Meier, W.R.; Abdou, M.A.; Kulcinski, G.L.; Moir, R.W.; Nobile, A.; Peterson, P.F.; Petti, D.A.; Schultz, K.R.; Tillack, M.; Yoda, M.

2001-01-01

The U.S. Department of Energy, Office of Fusion Energy Science (OFES) formed the Virtual Laboratory for Technology (VLT) to develop the technologies needed to support near term fusion experiments and to provide the basis for future magnetic and inertial fusion energy power plants. The scope of the inertial fusion energy (IFE) element of the VLT includes the fusion chamber, driver/chamber interface, target fabrication and injection, and safety and environmental assessment for IFE. Lawrence Livermore National Laboratory, in conjunction with other laboratories, universities and industry, has written an R and D plan to address the critical issues in these areas over the next 5 years in a coordinated manner. This paper provides an overview of the U.S. research activities addressing these critical issues. (author)

Creating a Test Validated Structural Dynamic Finite Element Model of the Multi-Utility Technology Test Bed Aircraft

Science.gov (United States)

Pak, Chan-Gi; Truong, Samson S.

2014-01-01

Small modeling errors in the finite element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of Multi Utility Technology Test Bed, X-56A, aircraft is the flight demonstration of active flutter suppression, and therefore in this study, the identification of the primary and secondary modes for the structural model tuning based on the flutter analysis of X-56A. The ground vibration test validated structural dynamic finite element model of the X-56A is created in this study. The structural dynamic finite element model of the X-56A is improved using a model tuning tool. In this study, two different weight configurations of the X-56A have been improved in a single optimization run.

Creating a FIESTA (Framework for Integrated Earth Science and Technology Applications) with MagIC

Science.gov (United States)

Minnett, R.; Koppers, A. A. P.; Jarboe, N.; Tauxe, L.; Constable, C.

2017-12-01

The Magnetics Information Consortium (https://earthref.org/MagIC) has recently developed a containerized web application to considerably reduce the friction in contributing, exploring and combining valuable and complex datasets for the paleo-, geo- and rock magnetic scientific community. The data produced in this scientific domain are inherently hierarchical and the communities evolving approaches to this scientific workflow, from sampling to taking measurements to multiple levels of interpretations, require a large and flexible data model to adequately annotate the results and ensure reproducibility. Historically, contributing such detail in a consistent format has been prohibitively time consuming and often resulted in only publishing the highly derived interpretations. The new open-source (https://github.com/earthref/MagIC) application provides a flexible upload tool integrated with the data model to easily create a validated contribution and a powerful search interface for discovering datasets and combining them to enable transformative science. MagIC is hosted at EarthRef.org along with several interdisciplinary geoscience databases. A FIESTA (Framework for Integrated Earth Science and Technology Applications) is being created by generalizing MagIC's web application for reuse in other domains. The application relies on a single configuration document that describes the routing, data model, component settings and external services integrations. The container hosts an isomorphic Meteor JavaScript application, MongoDB database and ElasticSearch search engine. Multiple containers can be configured as microservices to serve portions of the application or rely on externally hosted MongoDB, ElasticSearch, or third-party services to efficiently scale computational demands. FIESTA is particularly well suited for many Earth Science disciplines with its flexible data model, mapping, account management, upload tool to private workspaces, reference metadata, image

Digital Media Creates Youth Voices Heard

Directory of Open Access Journals (Sweden)

Jeff Sallee

2014-06-01

Full Text Available Oklahoma 4-H clubs and military service centers partnered with the Adobe Youth Voices (AYV program to give youth opportunities to raise their voices through digital media. This program reached out to underrepresented youth and gave them the tools and technology to effectively express themselves. The intent of this project was for 4-H members to create videos to educate, help and raise awareness in their communities of topics that were important to the youth. These experiences help youth gain knowledge towards helping others solve farm, home, and community problems. Participating youth selected issues that were important to them and created a short video, educating others and sharing their convictions on the topics of horse therapy, citizenship, bullying, and distracted driving.

Targeting mammalian organelles with internalizing phage (iPhage) libraries

Science.gov (United States)

Rangel, Roberto; Dobroff, Andrey S.; Guzman-Rojas, Liliana; Salmeron, Carolina C.; Gelovani, Juri G.; Sidman, Richard L.; Pasqualini, Renata; Arap, Wadih

2015-01-01

Techniques largely used for protein interaction studies and discovery of intracellular receptors, such as affinity capture complex purification and yeast two-hybrid, may produce inaccurate datasets due to protein insolubility, transient or weak protein interactions, or irrelevant intracellular context. A versatile tool to overcome these limitations as well as to potentially create vaccines and engineer peptides and antibodies as targeted diagnostic and therapeutic agents, is the phage display technique. We have recently developed a new technology for screening internalizing phage (iPhage) vectors and libraries utilizing a ligand/receptor-independent mechanism to penetrate eukaryotic cells. iPhage particles provide a unique discovery platform for combinatorial intracellular targeting of organelle ligands along with their corresponding receptors and to fingerprint functional protein domains in living cells. Here we explain the design, cloning, construction, and production of iPhage-based vectors and libraries, along with basic ligand-receptor identification and validation methodologies for organelle receptors. An iPhage library screening can be performed in ~8 weeks. PMID:24030441

CreatIng Web-based Math learnIng tool for TURKISH mIddle school students: Webquest

Directory of Open Access Journals (Sweden)

Aytac KURTULUS

2009-04-01

Full Text Available Internet is the most important product for the computer technology and it began to be used in many fields. Especially in the recent years, the usage of Internet has increased in the fields of communication, entertainment, advertisement, media, and technology. In Turkey, the usage of Internet is not used very common and active in primary and secondary education. The fast developments of the new technologies and the Web-Based Education Systems must be increased the importance of giving courses. In this study, the information to be aimed at is to introduce the WebQuest system, which was developed at San Diego State University by Bernie Dodge. A webQuest can be used web-based math learning tool for Turkish middle school students. Therefore, an example of geometry education WebQuest is given to introduce WebQuest system because WebQuest will be active in geometry teaching similar to the other subjects. An overview of WebQuest technology application and several resources for teachers and students interested in creating WebQuests can be found on The WebQutest Page (Dodge, 2001. Table 1 lists web sites that have many of these resources.

Targeted Technology Transfer to US Independents

Energy Technology Data Exchange (ETDEWEB)

E. Lance Cole

2009-09-30

The Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers, working in conjunction with the Independent Petroleum Association of America (IPAA), the U.S. Department of Energy (DOE) and selected universities, in 1994 as a national not-for-profit organization. Its goal is to transfer Exploration and Production (E&P) technology to the domestic upstream petroleum industry, in particular to the small independent operators. PTTC connects producers, technology providers and innovators, academia, and university/industry/government research and development (R&D) groups. From inception PTTC has received federal funding through DOE's oil and natural gas program managed by the National Energy Technology Laboratory (NETL). With higher funding available in its early years, PTTC was able to deliver well more than 100 workshops per year, drawing 6,000 or more attendees per year. Facing the reality of little or no federal funding in the 2006-2007 time frame, PTTC and the American Association of Petroleum Geologists (AAPG) worked together for PTTC to become a subsidiary organization of AAPG. This change brings additional organizational and financial resources to bear for PTTC's benefit. PTTC has now been 'powered by AAPG' for two full fiscal years. There is a clear sense that PTTC has stabilized and is strengthening its regional workshop and national technology transfer programs and is becoming more entrepreneurial in exploring technology transfer opportunities beyond its primary DOE contract. Quantitative accomplishments: PTTC has maintained its unique structure of a national organization working through Regional Lead Organizations (RLOs) to deliver local, affordable workshops. During the contract period PTTC consolidated from 10 to six regions efficiency and alignment with AAPG sections. The number of workshops delivered by its RLOs during the contract period is shown below. Combined attendance over the

Endogenous Technological Progress with Uncertainty and Carbon Abatement Polices

Energy Technology Data Exchange (ETDEWEB)

Cho, G.L. [Korea Energy Economics Institute, Euiwang (Korea)

2001-11-01

Most greenhouse gas abatement policy models tend to neglect a potentially important element that is relevant to the induced technology changes(ITC). These models that incorporate technological change treat such a change as autonomous, that is, unaffected by changes in prices brought about by policy reforms. However, climate change policies can create economic incentives to engage in more extensive R and D oriented toward the discovery of new production techniques that mitigate a reliance on convectional fuels, ultimately resulting in impacts on the policies themselves. In order to investigate the significance of induced technology for the attractiveness of abatement policies, this study develop the multi-sectoral dynamic CGE model by incorporating two characteristics of technological progress: the endogenous growth model with externality of technology in Romer (1986) and Lucas(1988) and the technological changes resulting from profit maximizing investment in R and D in Rebelo(1991) and Jones and Manuelli(1990). Furthermore, technological progress is affected by not only the economical factors but also the political and institutional system that cannot be captured in this model. This study considers such uncertainty in the technological progress as technology shock as in RBC school. This study shows that the presence of ITC implies lower costs of achieving a given abatement target in terms of the reduction cost per ton of carbon and GDP losses. The presence of ITC reduces the GDP losses by 0.9%p{approx}1.5%p compared with the absence of the ITC. As the abatement target is substantially high, R and D is reduced significantly even in the presence of ITC. Therefore, it is necessary to seriously consider the tax recycling for enhancing R and D investment, which minimizes the GDP losses. The reduction cost is highly sensitive to the uncertainty in technological progress. The technology shock leads the reduction cost to widely vary, in terms of standard deviation, 3

Creating an outcomes framework.

Science.gov (United States)

Doerge, J B

2000-01-01

Four constructs used to build a framework for outcomes management for a large midwestern tertiary hospital are described in this article. A system framework outlining a model of clinical integration and population management based in Steven Shortell's work is discussed. This framework includes key definitions of high-risk patients, target groups, populations and community. Roles for each level of population management and how they were implemented in the health care system are described. A point of service framework centered on seven dimensions of care is the next construct applied on each nursing unit. The third construct outlines the framework for role development. Three roles for nursing were created to implement strategies for target groups that are strategic disease categories; two of those roles are described in depth. The philosophy of nursing practice is centered on caring and existential advocacy. The final construct is the modification of the Dartmouth model as a common framework for outcomes. System applications of the scorecard and lessons learned in the 2-year process of implementation are shared

Technology strategy for cost-effective drilling and intervention; Technology Target Areas; TTA4 - Cost effective drilling and intervention

Energy Technology Data Exchange (ETDEWEB)

2007-07-01

The main goals of the OG21 initiative are to (1) develop new technology and knowledge to increase the value creation of Norwegian oil and gas resources and (2) enhance the export of Norwegian oil and gas technology. The OG21 Cost-effective Drilling and Intervention (CEDI) Technology Target Area (TTA) has identified some key strategic drilling and well intervention needs to help meet the goals of OG21. These key strategic drilling and well intervention needs are based on a review of present and anticipated future offshore-Norway drilling and well intervention conditions and the Norwegian drilling and well intervention industry. A gap analysis has been performed to assess the extent to which current drilling and well intervention research and development and other activities will meet the key strategic needs. Based on the identified strategic drilling and well intervention needs and the current industry res each and development and other activities, the most important technology areas for meeting the OG21 goals are: environment-friendly and low-cost exploration wells; low-cost methods for well intervention/sidetracks; faster and extended-reach drilling; deep water drilling, completion and intervention; offshore automated drilling; subsea and sub-ice drilling; drilling through basalt and tight carbonates; drilling and completion in salt formation. More specific goals for each area: reduce cost of exploration wells by 50%; reduce cost for well intervention/sidetracks by 50%; increase drilling efficiency by 40%; reduce drilling cost in deep water by 40 %; enable offshore automated drilling before 2012; enable automated drilling from seabed in 2020. Particular focus should be placed on developing new technology for low-cost exploration wells to stem the downward trends in the number of exploration wells drilled and the volume of discovered resources. The CEDI TTA has the following additional recommendations: The perceived gaps in addressing the key strategic drilling and

Vacuum Technology

Energy Technology Data Exchange (ETDEWEB)

Biltoft, P J

2004-10-15

The environmental condition called vacuum is created any time the pressure of a gas is reduced compared to atmospheric pressure. On earth we typically create a vacuum by connecting a pump capable of moving gas to a relatively leak free vessel. Through operation of the gas pump the number of gas molecules per unit volume is decreased within the vessel. As soon as one creates a vacuum natural forces (in this case entropy) work to restore equilibrium pressure; the practical effect of this is that gas molecules attempt to enter the evacuated space by any means possible. It is useful to think of vacuum in terms of a gas at a pressure below atmospheric pressure. In even the best vacuum vessels ever created there are approximately 3,500,000 molecules of gas per cubic meter of volume remaining inside the vessel. The lowest pressure environment known is in interstellar space where there are approximately four molecules of gas per cubic meter. Researchers are currently developing vacuum technology components (pumps, gauges, valves, etc.) using micro electro mechanical systems (MEMS) technology. Miniature vacuum components and systems will open the possibility for significant savings in energy cost and will open the doors to advances in electronics, manufacturing and semiconductor fabrication. In conclusion, an understanding of the basic principles of vacuum technology as presented in this summary is essential for the successful execution of all projects that involve vacuum technology. Using the principles described above, a practitioner of vacuum technology can design a vacuum system that will achieve the project requirements.

Affective ambiences created with lighting for older people

NARCIS (Netherlands)

Kuijsters, A.; Redi, J.; Ruyter, B.E.R. de; Seuntiens, P.; Heynderickx, I.

2015-01-01

Current lighting technologies provide huge flexibility in creating ambiences that may be adapted to the needs of an occupant in a room. These ambiences not only satisfy visual needs, but may also improve people’s well-being. This paper describes one possible application of adaptable light ambiences,

A Wiki Collaboration to Create National Guidelines: Tips for Professional Practice

Science.gov (United States)

Moser, Patt

2009-01-01

In 2006, technology directors from independent schools across the country had banded together and created "Principles of Good Practice" for technology in independent schools. These principles "define high standards and ethical behavior in key areas of independent school operations" (NAIS 2006). This author decided that it was time for the National…

Pre-School Children Creating and Communicating with Digital Technologies in the Home

Science.gov (United States)

McPake, Joanna; Plowman, Lydia; Stephen, Christine

2013-01-01

There is a limited literature on pre-school children's experiences with "digital technologies" at home and little discussion of the ways in which children harness these technologies for their own purposes. This paper discusses findings drawn from three studies that investigated the role of "domestic technologies" and…

Technology of micro- and macroshells and the problem of reactor targets

International Nuclear Information System (INIS)

Akunets, A.A.; Dorogotovtsev, V.M.; Merkul'ev, Yu.A.

1987-01-01

Technological principles, permitting to produce laser targets of 4.0 - 10 mm diameter are suggested. According to the given technique a particle of initial substance (drop or shell) with additions of a gas-forming agent under conditions similar to free fall, flies in the atmosphere of rarefied heat-exchange gas through a hot area. The process of its heating under conditions of a weak forced convective heat exchange is the main process taking much time. Starting heat treatment of a shell 4.0 mm in diameter with aspect ratio A = 200, i.e. thickness of 10 μm, the treatment can be finished with 10.0 mm diameter at A = 1300, i.e. with wall thickness 1.6 μm. Experimental testing has confirmed the evaluations. Shells of 4.0 mm diameter with A = 2500 are produced

Creating university spin-offs: a science-based design perspective

NARCIS (Netherlands)

Burg, van J.C.; Romme, A.G.L.; Gilsing, V.A.; Reymen, I.M.M.J.

2008-01-01

Academic entrepreneurship by means of university spin-offs commercializes technological breakthroughs, which may otherwise remain unexploited. However, many universities face difficulties in creating spin-offs. This article adopts a science-based design approach to connect scholarly research with

Creating university spin-offs : a science-based design perspective

NARCIS (Netherlands)

Burg, van J.C.; Romme, A.G.L.; Gilsing, V.A.; Reymen, I.M.M.J.; Dan Remenyi, xx

2007-01-01

Academic entrepreneurship by means of university spin-offs commercializes technological breakthroughs, which may otherwise remain unexploited. However, many universities face difficulties in creating spin-offs. This article adopts a science-based design approach, to connect scholarly research with

Picture models for 2-scene comics creating system

Directory of Open Access Journals (Sweden)

Miki UENO

2015-03-01

Full Text Available Recently, computer understanding pictures and stories becomes one of the most important research topics in computer science. However, there are few researches about human like understanding by computers because pictures have not certain format and contain more lyric aspect than that of natural laguage. For picture understanding, a comic is the suitable target because it is consisted by clear and simple plot of stories and separated scenes.In this paper, we propose 2 different types of picture models for 2-scene comics creating system. We also show the method of the application of 2-scene comics creating system by means of proposed picture model.

Future of brain stimulation: new targets, new indications, new technology.

Science.gov (United States)

Hariz, Marwan; Blomstedt, Patric; Zrinzo, Ludvic

2013-11-01

In the last quarter of a century, DBS has become an established neurosurgical treatment for Parkinson's disease (PD), dystonia, and tremors. Improved understanding of brain circuitries and their involvement in various neurological and psychiatric illnesses, coupled with the safety of DBS and its exquisite role as a tool for ethical study of the human brain, have unlocked new opportunities for this technology, both for future therapies and in research. Serendipitous discoveries and advances in structural and functional imaging are providing abundant "new" brain targets for an ever-increasing number of pathologies, leading to investigations of DBS in diverse neurological, psychiatric, behavioral, and cognitive conditions. Trials and "proof of concept" studies of DBS are underway in pain, epilepsy, tinnitus, OCD, depression, and Gilles de la Tourette syndrome, as well as in eating disorders, addiction, cognitive decline, consciousness, and autonomic states. In parallel, ongoing technological development will provide pulse generators with longer battery longevity, segmental electrode designs allowing a current steering, and the possibility to deliver "on-demand" stimulation based on closed-loop concepts. The future of brain stimulation is certainly promising, especially for movement disorders-that will remain the main indication for DBS for the foreseeable future-and probably for some psychiatric disorders. However, brain stimulation as a technique may be at risk of gliding down a slippery slope: Some reports indicate a disturbing trend with suggestions that future DBS may be proposed for enhancement of memory in healthy people, or as a tool for "treatment" of "antisocial behavior" and for improving "morality." © 2013 International Parkinson and Movement Disorder Society.

Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration.

Science.gov (United States)

Nikitichev, Daniil I; Shakir, Dzhoshkun I; Chadebecq, François; Tella, Marcel; Deprest, Jan; Stoyanov, Danail; Ourselin, Sébastien; Vercauteren, Tom

2017-02-23

We have developed a calibration target for use with fluid-immersed endoscopes within the context of the GIFT-Surg (Guided Instrumentation for Fetal Therapy and Surgery) project. One of the aims of this project is to engineer novel, real-time image processing methods for intra-operative use in the treatment of congenital birth defects, such as spina bifida and the twin-to-twin transfusion syndrome. The developed target allows for the sterility-preserving optical distortion calibration of endoscopes within a few minutes. Good optical distortion calibration and compensation are important for mitigating undesirable effects like radial distortions, which not only hamper accurate imaging using existing endoscopic technology during fetal surgery, but also make acquired images less suitable for potentially very useful image computing applications, like real-time mosaicing. In this paper proposes a novel fabrication method to create an affordable, sterilizable calibration target suitable for use in a clinical setup. This method involves etching a calibration pattern by laser cutting a sandblasted stainless steel sheet. This target was validated using the camera calibration module provided by OpenCV, a state-of-the-art software library popular in the computer vision community.

From Pipe Dream to Reality: Creating a Technology-Rich School Environment.

Science.gov (United States)

Crafton, John A.

1998-01-01

Methuen Public Schools, Massachusetts, has become a wired school system with computers in every classroom, Internet access, and state-of-the-art mixed-media. Five citizens who work in the technology industry formed a steering committee to drive the project. A long-term partnership with a private vendor, Lucent Technologies, addresses the…

Uncertainties in key low carbon power generation technologies - Implication for UK decarbonisation targets

International Nuclear Information System (INIS)

Kannan, R.

2009-01-01

The UK government's economy-wide 60% carbon dioxide reduction target by 2050 requires a paradigm shift in the whole energy system. Numerous analytical studies have concluded that the power sector is a critical contributor to a low carbon energy system, and electricity generation has dominated the policy discussion on UK decarbonisation scenarios. However, range of technical, social and market challenges, combined with alternate market investment strategies mean that large scale deployment of key classes of low carbon electricity technologies is fraught with uncertainty. The UK MARKAL energy systems model has been used to investigate these long-term uncertainties in key electricity generation options. A range of power sector specific parametric sensitivities have been performed under a 'what-if' framework to provide a systematic exploration of least-cost energy system configurations under a broad, integrated set of input assumptions. In this paper results of six sensitivities, via restricted investments in key low carbon technologies to reflect their technical and political uncertainties, and an alternate investment strategies from perceived risk and other barriers, have been presented. (author)

Materials technology applied to nuclear accelerator targets

International Nuclear Information System (INIS)

Barthell, B.L.

1986-01-01

The continuing requests for both shaped and flat, very low areal density metal foils have led to the development of metallurgical quality, high strength products. Intent of this paper is to show methods of forming structures on various substrates using periodic vapor interruptions, alternating anodes, and mechanical peening to alter otherwise unacceptable grain morphology which both lowers tensile strength and causes high stresses in thin films. The three technologies, physical vapor deposition, electrochemistry, and chemical vapor deposition and their thin film products can benefit from the use of laminate technology and control of grain structure morphology through the use of materials research and technology

The Ultimate Technology

DEFF Research Database (Denmark)

Riis, Søren

2013-01-01

One of the most influential philosophers of the 20th century, Martin Heidegger (1889-1976), died prior to the remarkable cloning of the sheep Dolly and before Dr. Venter started his experiments on creating synthetic life, and he never explicitly discussed living technologies. However, by reinterp......One of the most influential philosophers of the 20th century, Martin Heidegger (1889-1976), died prior to the remarkable cloning of the sheep Dolly and before Dr. Venter started his experiments on creating synthetic life, and he never explicitly discussed living technologies. However......, by reinterpreting his notion of "modern technology," this article shows how it is possible to philosophically assess living technologies and to recognize ways in which Heidegger anticipated this phenomenon with his notion of cybernetics. The interpretation elucidates the fundamental process of technology becoming...... living and simultaneously presents living technology as the ultimate technology. The thesis of this article is that living technology is not just one more technology; rather, it is the perfection of technology as understood by Aristotle. Aristotle's thinking is in this way a key example of a profound...

SPATIAL ANALYSIS TO SUPPORT GEOGRAPHIC TARGETING OF GENOTYPES TO ENVIRONMENTS

Directory of Open Access Journals (Sweden)

Glenn eHyman

2013-03-01

Full Text Available Crop improvement efforts have benefited greatly from advances in available data, computing technology and methods for targeting genotypes to environments. These advances support the analysis of genotype by environment interactions to understand how well a genotype adapts to environmental conditions. This paper reviews the use of spatial analysis to support crop improvement research aimed at matching genotypes to their most appropriate environmental niches. Better data sets are now available on soils, weather and climate, elevation, vegetation, crop distribution and local conditions where genotypes are tested in experimental trial sites. The improved data are now combined with spatial analysis methods to compare environmental conditions across sites, create agro-ecological region maps and assess environment change. Climate, elevation and vegetation data sets are now widely available, supporting analyses that were much more difficult even five or ten years ago. While detailed soil data for many parts of the world remains difficult to acquire for crop improvement studies, new advances in digital soil mapping are likely to improve our capacity. Site analysis and matching and regional targeting methods have advanced in parallel to data and technology improvements. All these developments have increased our capacity to link genotype to phenotype and point to a vast potential to improve crop adaptation efforts.

SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker Discovery.

Science.gov (United States)

Zha, Haihong; Cai, Yuping; Yin, Yandong; Wang, Zhuozhong; Li, Kang; Zhu, Zheng-Jiang

2018-03-20

The complexity of metabolome presents a great analytical challenge for quantitative metabolite profiling, and restricts the application of metabolomics in biomarker discovery. Targeted metabolomics using multiple-reaction monitoring (MRM) technique has excellent capability for quantitative analysis, but suffers from the limited metabolite coverage. To address this challenge, we developed a new strategy, namely, SWATHtoMRM, which utilizes the broad coverage of SWATH-MS technology to develop high-coverage targeted metabolomics method. Specifically, SWATH-MS technique was first utilized to untargeted profile one pooled biological sample and to acquire the MS 2 spectra for all metabolites. Then, SWATHtoMRM was used to extract the large-scale MRM transitions for targeted analysis with coverage as high as 1000-2000 metabolites. Then, we demonstrated the advantages of SWATHtoMRM method in quantitative analysis such as coverage, reproducibility, sensitivity, and dynamic range. Finally, we applied our SWATHtoMRM approach to discover potential metabolite biomarkers for colorectal cancer (CRC) diagnosis. A high-coverage targeted metabolomics method with 1303 metabolites in one injection was developed to profile colorectal cancer tissues from CRC patients. A total of 20 potential metabolite biomarkers were discovered and validated for CRC diagnosis. In plasma samples from CRC patients, 17 out of 20 potential biomarkers were further validated to be associated with tumor resection, which may have a great potential in assessing the prognosis of CRC patients after tumor resection. Together, the SWATHtoMRM strategy provides a new way to develop high-coverage targeted metabolomics method, and facilitates the application of targeted metabolomics in disease biomarker discovery. The SWATHtoMRM program is freely available on the Internet ( http://www.zhulab.cn/software.php ).

Managing Technology in Our Schools: Establishing Goals and Creating a Plan

Science.gov (United States)

Price, Betsy

2007-01-01

Schools are at a point for change, about to incorporate technology as never before in the nation's classrooms. For this to happen, the input of savvy business managers is required. This book is for those who will not only be responsible for managing and financing technology budgets, but for providing the leadership to govern. The book reflects on…

New design targets and new automated technology for the production of radionuclides with high specificity radioactivity in nuclear research reactors

International Nuclear Information System (INIS)

Gerasimov, A.S.; Kiselev, G.V.

1997-01-01

Current demands of industry require the application of radionuclides with high specific radioactivity under low consumption of neutrons. To provide this aim staff of ITEP Reactor Department investigated the different type AEs of start targets for the production of the main radionuclides; Co-60, Ir-192 and others. In first turn the targets of Co and Ir without the block-effect of neutron flux (with low absorption of neutrons) were investigated. The following principal results were received for example for Ir-192: block effect is equal 0.086 for diameter of Ir target mm and is equal 0.615 for diameter Ir target 0.5mm. It means average neutron flux for Ir target diameter 0.5mm and therefore the production of Ir-192 will be at 10 times more than for diameter 6.0mm. To provide the automated technology of the manufacture of radioactive sources with radionuclides with high specific radioactivity it was proposed that the compound targets for the irradiation of ones and for the management with the irradiated targets. Different types of compound targets were analyzed. (authors)

3D Printing Prototypes for Healthcare Professionals: Creating a Reciprocating Syringe.

Science.gov (United States)

Rothenberg, Steven; Abdullah, Selwan; Hirsch, Jeffrey

2017-10-01

3D printing (additive manufacturing) has been around since 1984, but interest in the technology has increased exponentially as it has become both accessible and inexpensive. The applications of the technology in healthcare are still being explored; however, initial forays have been encouraging. It has the potential to revolutionize the process of prototyping for healthcare professionals by democratizing the process and enhancing collaboration, making it cheaper to do iterative prototyping with little or no engineering experience. This case report details the creation of a multi-lumen reciprocating syringe with 3D printing. The product has been created and tested using a variety of publicly available resources. It provides a detailed overview of the approach and the framework required to create such a medical device. However, the implications of this report are much larger than this one product, and the fundamental ideas discussed here could be used for creating customized solutions for many healthcare problems.

Sequence based polymorphic (SBP marker technology for targeted genomic regions: its application in generating a molecular map of the Arabidopsis thaliana genome

Directory of Open Access Journals (Sweden)

Sahu Binod B

2012-01-01

Full Text Available Abstract Background Molecular markers facilitate both genotype identification, essential for modern animal and plant breeding, and the isolation of genes based on their map positions. Advancements in sequencing technology have made possible the identification of single nucleotide polymorphisms (SNPs for any genomic regions. Here a sequence based polymorphic (SBP marker technology for generating molecular markers for targeted genomic regions in Arabidopsis is described. Results A ~3X genome coverage sequence of the Arabidopsis thaliana ecotype, Niederzenz (Nd-0 was obtained by applying Illumina's sequencing by synthesis (Solexa technology. Comparison of the Nd-0 genome sequence with the assembled Columbia-0 (Col-0 genome sequence identified putative single nucleotide polymorphisms (SNPs throughout the entire genome. Multiple 75 base pair Nd-0 sequence reads containing SNPs and originating from individual genomic DNA molecules were the basis for developing co-dominant SBP markers. SNPs containing Col-0 sequences, supported by transcript sequences or sequences from multiple BAC clones, were compared to the respective Nd-0 sequences to identify possible restriction endonuclease enzyme site variations. Small amplicons, PCR amplified from both ecotypes, were digested with suitable restriction enzymes and resolved on a gel to reveal the sequence based polymorphisms. By applying this technology, 21 SBP markers for the marker poor regions of the Arabidopsis map representing polymorphisms between Col-0 and Nd-0 ecotypes were generated. Conclusions The SBP marker technology described here allowed the development of molecular markers for targeted genomic regions of Arabidopsis. It should facilitate isolation of co-dominant molecular markers for targeted genomic regions of any animal or plant species, whose genomic sequences have been assembled. This technology will particularly facilitate the development of high density molecular marker maps, essential for

Assistive Technology for Young Children: Creating Inclusive Learning Environments

Science.gov (United States)

Sadao, Kathleen C.; Robinson, Nancy B.

2010-01-01

Assistive technology (AT) can help young children with disabilities fully participate in natural, inclusive learning environments--but many early childhood professionals don't get the training they need to harness the power of AT. Fill that gap with this unintimidating, reader-friendly resource, the go-to guide to recommended AT practice for…

Teacher-Created Electronic Books: Integrating Technology to Support Readers with Disabilities

Science.gov (United States)

Rhodes, Joan A.; Milby, Tammy M.

2007-01-01

The No Child Left Behind Act of 2001 holds U.S. schools accountable for the yearly assessment of all students as they progress toward meeting state educational goals. Students with disabilities continue to be a focal point for improving student achievement at the school and district levels. Creating teacher-made electronic books is an effective…

Highlights from the 2015 WIN Symposium: novel targets, innovative agents, and advanced technologies-a WINning strategy?

Science.gov (United States)

Schilsky, Richard L

2015-01-01

The worldwide innovative networking (WIN) consortium comprises a global alliance of 28 academic and clinical cancer centres, 11 pharmaceutical and technology companies and five charitable or health payer organisations. Since its inception the consortium has striven to provide a forum for all of its members to network, share information and experience, and perform clinical trials with the overarching goal of advancing the care of patients with cancer through the use of precision medicine. The annual 2-day WIN Symposium is the most visible output of the consortium and provides an opportunity for around 400 experts and other delegates to meet and discuss the latest research and initiatives in personalised cancer medicine. The seventh WIN Symposium, held in Paris, France, 29-30 June 2015, consisted of nine plenary and eight poster sessions that covered the overarching theme of novel targets, innovative agents, and advanced technologies being a winning strategy. Highlights included discussions of immune mechanisms and ways to target the cancer immunome and systems biology approaches to supporting personalised cancer. The latest data from the BATTLE-2 and WINther trials were discussed, and round table discussions were held that focused on how best to design the next generation of clinical trials, which included SPRING, SUMMER, and BOOSTER being initiated by the WIN Consortium.

Regulatory barriers to hazardous waste technology innovation

International Nuclear Information System (INIS)

Kuusinen, T.L.; Siegel, M.R.

1991-02-01

The primary federal regulatory programs that influence the development of new technology for hazardous waste are the Resource Conservation and Recovery Act (RCRA) and the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA, also commonly known as Superfund). Two important aspects of RCRA that can create barriers to hazardous waste technology innovation are technology-based waste pre-treatment standards and a cumbersome permitting program. By choosing a technology-based approach to the RCRA land disposal restrictions program, the US Environmental Protection Agency (EPA) has simultaneously created tremendous demand for the technologies specified in its regulations, while at the same time significantly reduced incentives for technology innovation that might have otherwise existed. Also, the RCRA hazardous waste permitting process can take years and cost hundreds of thousands of dollars. The natural tendency of permit writers to be cautious of unproven (i.e., innovative) technology also can create a barrier to deployment of new technologies. EPA has created several permitting innovations, however, to attempt to mitigate this latter barrier. Understanding the constraints of these permitting innovations can be important to the success of hazardous waste technology development programs. 3 refs

PHILOSOPHICAL AND ANTHROPOLOGICAL IMPORTANCE OF DEVELOPMENT OF ARTIFICIALLY CREATED INTELLIGENT SYSTEMS

Directory of Open Access Journals (Sweden)

Yu. D. Gensitskiy

2015-12-01

Full Text Available Purpose. Understanding the philosophical and anthropological importance of the development the artificial intelligence systems requires the analysis of the socio and anthropological content of intercomputer problems of interaction in the context of media philosophical praxis, anthropological maintenance of intellect nature, considering the specifics of the concept of artificial intelligence systems in the environment of M2M development of socio-cognitive practices of intercomputer interaction of social and humanitarian potential. Methodology. The implementation target is seen in the use of scientific and theoretical basis of the media philosophical, philosophical anthropology, the media philosophical approach to understanding society, science and technology, the use of publications on selected topics of research. Scientific novelty. The concept of artificial intelligence systems in the aspect of social and humanitarian potential of their formation and development in the environment of M2M was considered. The problems of machine learning as technology transformation M2M were analysed. The anthropological threats to the development of artificially created intelligent systems were defined. Conclusions. From the global risks point of view, one of the most critical circumstances due to the artificial intelligent system can strengthen its intelligence very quickly. The obvious reason for suspecting such an opportunity – a recursive self-improvement. Such system becomes smarter, including the intelligent writing of internal cognitive function, that the ability to rewrite their existing cognitive function to make it work better. This will make such systems more intelligent, and smarter in terms of the processing itself. The success of artificial intelligence may be the beginning of the end of the human race. Almost any technology falling into malicious hands reveals the potential for harm, but when it comes to artificial intelligent system, there is a

Use of technology to provide competitive advantage

International Nuclear Information System (INIS)

Clark, P. D.

1999-01-01

The role of technology in plotting a new paradigm is explored by means of reviewing NOVA Chemicals' technology strategy for feedstocks, petrochemicals and polymers. As part of this transformation of technology from that of a servant to a key contributor to the success of the company, the expansion (in a 50/50 joint venture with DOW/Union Carbide) of a mammoth 2.8 billion pound ethylene plant at Joffre, Alberta is 'the jewel in the crown'. This plant, with the two ethylene units already on site will make Joffre in the year 2000 the world's largest single site for the manufacture of ethylene. An 800 million pound Advanced SCLAIRTECH T M polystyrene plant, (a proprietary process for the manufacture of high performance polymers initially developed, but considered 'non-strategic' to their own needs, by DuPont and sold to NOVA Chemicals for $ 45 million in 1994), the largest single train of its kind in the world, is also under construction. Also in the early stages of construction on the site is a large linear alpha olefin plant owned by BP-Amoco to supply co-monomer to the polyethylene plant, To back up these facilities, there is a 400 MW cogeneration unit to supply power and steam. NOVA Chemicals Research and Technology Laboratory is a focused world class research facility with an annual budget of $ 37 million, combined with the active collaboration with all major Canadian universities, and targeted projects with other universities around the world , are all necessary components of creating and acquiring the technology that is required to achieve the corporate goals of the company. The high level of investment in research and technology is seen as the pathway to fundamentally change the business and create value which can be realized in the marketplace. Research and technology also help the company to advance the competitiveness of their own processes, keep the company on the cutting edge of technology, and assure its survival among the leaders of the industry

Creating Start-up Companies around NCI Inventions | Poster

Science.gov (United States)

By Karen Surabian, Thomas Stackhouse, and Rose Freel, Contributing Writers, and Rosemarie Truman, Guest Writer The National Cancer Institute (NCI), led by the Technology Transfer Center (TTC),  the Avon Foundation, and The Center for Advancing Innovation have partnered to create a “first-of-a-kind” Breast Cancer Start-up Challenge.

Environmental labelling as a marketing concept to create added value for flower chains: How to create a horticultural chain based on responsive consumer information

NARCIS (Netherlands)

Dam, van Y.K.; Lans, van der I.A.; Zimmerman, K.L.

2004-01-01

We investigated the possibility to create markets for environmentally friendly grown flowers and plants by combining a push and a pull strategy. Consumer research revealed that the main pull should come from a target segment (one-fifth of the population) of heavy flower users that are either

3D game environments create professional 3D game worlds

CERN Document Server

Ahearn, Luke

2008-01-01

The ultimate resource to help you create triple-A quality art for a variety of game worlds; 3D Game Environments offers detailed tutorials on creating 3D models, applying 2D art to 3D models, and clear concise advice on issues of efficiency and optimization for a 3D game engine. Using Photoshop and 3ds Max as his primary tools, Luke Ahearn explains how to create realistic textures from photo source and uses a variety of techniques to portray dynamic and believable game worlds.From a modern city to a steamy jungle, learn about the planning and technological considerations for 3D modelin

Creating the next generation control system software

International Nuclear Information System (INIS)

Schultz, D.E.

1989-01-01

A new 1980's style support package for future accelerator control systems is proposed. It provides a way to create accelerator applications software without traditional programming. Visual Interactive Applications (VIA) is designed to meet the needs of expanded accelerator complexes in a more cost effective way than past experience with procedural languages by using technology from the personal computer and artificial intelligence communities. 4 refs

Targeted resequencing and variant validation using pxlence PCR assays

Directory of Open Access Journals (Sweden)

Frauke Coppieters

2016-01-01

Full Text Available The advent of next-generation sequencing technologies had a profound impact on molecular diagnostics. PCR is a popular method for target enrichment of disease gene panels. Using our proprietary primer-design pipeline, primerXL, we have created almost one million assays covering over 98% of the human exome. Here we describe the assay specification and both in silico and wet-lab validation of a selected set of 2294 assays using both next-generation sequencing and Sanger sequencing. Using a universal PCR protocol without optimization, these assays result in high coverage uniformity and limited non-specific coverage. In addition, data indicates a positive correlation between the predictive in silico specificity score and the amount of assay non-specific coverage.

Targeted killing with drones? Old arguments, new technologies

Directory of Open Access Journals (Sweden)

Meisels Tamar

2018-01-01

Full Text Available The question of how to contend with terrorism in keeping with our preexisting moral and legal commitments now challenges Europe as well as Israel and the United States: how do we apply Just War Theory and International Law to asymmetrical warfare, specifically to our counter terrorism measures? What can the classic moral argument in Just and Unjust Wars teach us about contemporary targeted killings with drones? I begin with a defense of targeted killing, arguing for the advantages of pin pointed attacks over any alternative measure available for combatting terrorism. Assuming the legitimacy of killing combatants in wartime, I argue, there is nothing wrong, and in fact much that is right, with targeting particular terrorists selected by name, as long as their assassinations can be reasonably expected to reduce terrorist hostilities rather than increase it. Subsequently, I offer some further thoughts and comments on the use of remotely piloted aircrafts to carry out targeted killings, and address the various sources for discomfort with this practice identified by Michael Walzer and others.

Low-enriched uranium high-density target project. Compendium report

Energy Technology Data Exchange (ETDEWEB)

Vandegrift, George; Brown, M. Alex; Jerden, James L.; Gelis, Artem V.; Stepinski, Dominique C.; Wiedmeyer, Stanley; Youker, Amanda; Hebden, Andrew; Solbrekken, G; Allen, C; Robertson., D; El-Gizawy, Sherif; Govindarajan, Srisharan; Hoyer, Annemarie; Makarewicz, Philip; Harris, Jacob; Graybill, Brian; Gunn, Andy; Berlin, James; Bryan, Chris; Sherman, Steven; Hobbs, Randy; Griffin, F. P.; Chandler, David; Hurt, C. J.; Williams, Paul; Creasy, John; Tjader, Barak; McFall, Danielle; Longmire, Hollie

2016-09-01

At present, most ⁹⁹Mo is produced in research, test, or isotope production reactors by irradiation of highly enriched uranium targets. To achieve the denser form of uranium needed for switching from high to low enriched uranium (LEU), targets in the form of a metal foil (~125-150 µm thick) are being developed. The LEU High Density Target Project successfully demonstrated several iterations of an LEU-fission-based Mo-99 technology that has the potential to provide the world’s supply of Mo-99, should major producers choose to utilize the technology. Over 50 annular high density targets have been successfully tested, and the assembly and disassembly of targets have been improved and optimized. Two target front-end processes (acidic and electrochemical) have been scaled up and demonstrated to allow for the high-density target technology to mate up to the existing producer technology for target processing. In the event that a new target processing line is started, the chemical processing of the targets is greatly simplified. Extensive modeling and safety analysis has been conducted, and the target has been qualified to be inserted into the High Flux Isotope Reactor, which is considered above and beyond the requirements for the typical use of this target due to high fluence and irradiation duration.

Technology in Mental Health: Creating New Knowledge and Inventing the Future of Services.

Science.gov (United States)

Ben-Zeev, Dror

2017-02-01

The mental health services now in place are intrinsically linked with the technology that has been at our disposal for decades of research and practice. Advancements in Web, mobile, sensor, and informatics technology can do more than serve as tools to enhance existing models of care. Novel technologies can help us better understand the very nature of mental illness and revise our fundamental assumptions about the structure, boundaries, and modalities of mental health treatment. Recognizing the unprecedented opportunities new technology offers to improve the outcomes of people with mental illness, Psychiatric Services announces a new column on technology and mental health.

Creating Learning Environment Connecting Engineering Design and 3D Printing

Science.gov (United States)

Pikkarainen, Ari; Salminen, Antti; Piili, Heidi

Engineering education in modern days require continuous development in didactics, pedagogics and used practical methods. 3D printing provides excellent opportunity to connect different engineering areas into practice and produce learning by doing applications. The 3D-printing technology used in this study is FDM (Fused deposition modeling). FDM is the most used 3D-printing technology by commercial numbers at the moment and the qualities of the technology makes it popular especially in academic environments. For achieving the best result possible, students will incorporate the principles of DFAM (Design for additive manufacturing) into their engineering design studies together with 3D printing. This paper presents a plan for creating learning environment for mechanical engineering students combining the aspects of engineering design, 3D-CAD learning and AM (additive manufacturing). As a result, process charts for carrying out the 3D printing process from technological point of view and design process for AM from engineering design point of view were created. These charts are used in engineering design education. The learning environment is developed to work also as a platform for Bachelor theses, work-training environment for students, prototyping service centre for cooperation partners and source of information for mechanical engineering education in Lapland University of Applied Sciences.

Progress in ISOL target-ion source systems

Energy Technology Data Exchange (ETDEWEB)

Koester, U. [Institut Laue Langevin, 6 Rue Jules Horowitz, F-38042 Grenoble Cedex 9 (France); ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland)], E-mail: koester@ill.fr; Arndt, O. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Bouquerel, E.; Fedoseyev, V.N. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Franberg, H. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Laboratory for Radio- and Environmental Chemistry, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Joinet, A. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Centre d' Etude Spatiale des Rayonnements, 9 Av. du Colonel Roche, F-31028 Toulouse Cedex 4 (France); Jost, C. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Kerkines, I.S.K. [Laboratory of Physical Chemistry, National and Kapodistrian University of Athens, Department of Chemistry, Zografou 157 71, GR (Greece); Cherry L. Emerson Center for Scientific Computation and Department of Chemistry, Emory University, Atlanta, GA 30322 (United States); Kirchner, R. [Gesellschaft fuer Schwerionenforschung, Planckstr. 1, D-64291 Darmstadt (Germany)

2008-10-15

The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

Progress in ISOL target-ion source systems

International Nuclear Information System (INIS)

Koester, U.; Arndt, O.; Bouquerel, E.; Fedoseyev, V.N.; Franberg, H.; Joinet, A.; Jost, C.; Kerkines, I.S.K.; Kirchner, R.

2008-01-01

The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

"Create" or "Buy" : Internal vs. External Sources of Innovation and Firm Productivity

OpenAIRE

Choi, Jieun

2017-01-01

The role of innovation in improving productivity might vary according to a country's relative position in technology advancement. Frontier countries might benefit more from policies that promote firms' internal innovation (create), while follower countries would gain more from policies favoring the adoption of existing technologies through innovation outsourcing (buy). However, in many cou...

Photon technology. Laser process technology; Photon technology. Laser process gijutsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

For developing laser process technology by interaction between substance and photon, the present state, system, R and D issues and proposal of such technology were summarized. Development of the photon technology aims at the modification of bonding conditions of substances by quantum energy of photon, and the new process technology for generating ultra- high temperature and pressure fields by concentrating photon on a minute region. Photon technology contributes to not only the conventional mechanical and thermal forming and removal machining but also function added machining (photon machining) in quantum level and new machining technology ranging from macro- to micro-machining, creating a new industrial field. This technology extends various fields from the basis of physics and chemistry to new bonding technology. Development of a compact high-quality high-power high-efficiency photon source, and advanced photon transmission technology are necessary. The basic explication of an unsolved physicochemical phenomenon related to photon and substance, and development of related application technologies are essential. 328 refs., 147 figs., 13 tabs.

Target support for inertial confinement fusion

International Nuclear Information System (INIS)

Schultz, K.R.

1995-08-01

General Atomics (GA) plays an important industrial support role for the US Inertial Confinement Fusion (ICF) program in the area of target technology. This includes three major activities: target fabrication support, target handling systems development, and target chamber design. The work includes target fabrication for existing ICF experiments, target and target system development for future experiments, and target research and target chamber design for experiments on future machines, such as the National Ignition Facility (NIF)

Applying Nano technology to Human Health: Revolution in Biomedical Sciences

International Nuclear Information System (INIS)

Shrivastava, S.; Dash, D.

2009-01-01

Recent research on bio systems at the nano scale has created one of the most dynamic science and technology domains at the confluence of physical sciences, molecular engineering, biology, biotechnology, and medicine. This domain includes better understanding of living and thinking systems, revolutionary biotechnology processes, synthesis of new drugs and their targeted delivery, regenerative medicine, necrophorum engineering, and developing a sustainable environment. Nano bio systems research is a priority in many countries and its relevance within nano technology is expected to increase in the future. The realisation that the nano scale has certain properties needed to solve important medical challenges and cater to unmet medical needs is driving nano medical research. The present review explores the significance of nano science and latest nano technologies for human health. Addressing the associated opportunities, the review also suggests how to manage far-reaching developments in these areas

Technology and Nursing

OpenAIRE

Maria Vera Lúcia Moreira Leitão Cardoso

2012-01-01

In the present age we cannot disassociate from emerging issues, which involve science, communication, health and technology, the influence of media, technological advances, and the use of computers in all spheres of life. The concepts created for technology cover various evaluation approaches, which depend upon which type of technology, approaches, usefulness and influences in a particular area of knowledge. Technological advances cover several areas, figuring quantum physics, nanotechnology,...

Memory for found targets interferes with subsequent performance in multiple-target visual search.

Science.gov (United States)

Cain, Matthew S; Mitroff, Stephen R

2013-10-01

Multiple-target visual searches--when more than 1 target can appear in a given search display--are commonplace in radiology, airport security screening, and the military. Whereas 1 target is often found accurately, additional targets are more likely to be missed in multiple-target searches. To better understand this decrement in 2nd-target detection, here we examined 2 potential forms of interference that can arise from finding a 1st target: interference from the perceptual salience of the 1st target (a now highly relevant distractor in a known location) and interference from a newly created memory representation for the 1st target. Here, we found that removing found targets from the display or making them salient and easily segregated color singletons improved subsequent search accuracy. However, replacing found targets with random distractor items did not improve subsequent search accuracy. Removing and highlighting found targets likely reduced both a target's visual salience and its memory load, whereas replacing a target removed its visual salience but not its representation in memory. Collectively, the current experiments suggest that the working memory load of a found target has a larger effect on subsequent search accuracy than does its perceptual salience. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Simulations of effusion from ISOL target/ion source systems

International Nuclear Information System (INIS)

Mustapha, B.; Nolen, J.A.

2004-01-01

Monte Carlo simulations of the low- and high-conductivity Target/Ion Source systems used at Oak Ridge National Laboratory for effusion measurements are performed. Comparisons with the corresponding experimental data for the different geometries are presented and discussed. Independent checks of the simulation using data for simple geometries and using the conductance approach well known in vacuum technology are performed. A simulation-based comparison between the low- and high-conductivity systems is also presented

Fiscal 2000 survey report on technological trends. Survey on trend of high-density energy beam technology concerning conservation of energy; 2000 nendo gijutsu doko nado chosa hokokusho. Energy shiyo gorika ni kakawaru komitsudo energy beam technology no doko chosa

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

There is a possibility that machining technology using high-density energy beam will bring an epoch-making change to micro-nano area processing. In particular, a laser beam having high controllability is indispensable. This is a report of the fiscal 2000 survey. The survey was conducted on laser beam generation, control and nano-diagnostic techniques, micro-nano optics technologies and machining technologies, with the development problems and targets summarized. Laser beam generation/control technologies, which become the basic tools for micro-nano manufacturing, were investigated, as were inspection technologies for the purpose of checking the functions of nano structures created. Particularly, the investigation elucidated the significance of development of a femtosecond solid state laser based on a semiconductor laser and the control techniques of their phase. Further, necessity was emphasized in developing X-ray probing, infrared and terahertz spectroscopy which are essential for nano-diagnostic techniques. In optics technologies, the paper described the importance of photonic crystals which enable less-than-wavelength machining or electrical beam control using interference effect. The possibility of fabricating photocatalysts with nano-particles was also mentioned, as was the manufacturing of nano-functional structures. (NEDO)

Technology strategy for deepwater and subsea production systems 2008 update; Technology Target Areas; TTA7 - Deep water and subsea prodution technology

Energy Technology Data Exchange (ETDEWEB)

2008-07-01

Executive summary 'Deepwater and Subsea Production Systems' has been identified as one of the eight new Technology Target Areas (TTAs) in Norway's technology strategy for the Oil and Gas sector. This TTA covers deepwater floating production systems, subsea systems (except subsea processing technologies which are addressed by TTA6) and arctic development systems (in both shallow and deepwater). The total hydrocarbon reserves worldwide, which are enabled by the technologies under this TTA exceed 400 billion boe which, itself exceeds the proven reserves of Saudi Arabia. For deepwater developments the long term technical challenge is to develop flexible and adaptive systems which are better able to cope with subsurface uncertainties e.g. compartmentalisation and provide required access to the reservoir to enable successful recovery. More specific medium term challenges relate to developing solutions for harsh environmental conditions such as those offshore Norway and to develop cost effective methods of installing subsea hardware in deep and ultra deep water without requiring expensive crane vessels. For subsea systems the challenge is to develop solutions for ultra deepwater without increasing costs, so that Norway's leading export position in this area can be maintained and strengthened. Considering developments in the arctic, Norwegian industry is already well placed through its familiarity with arctic climate, close relationship with Russia and involvement in Sakhalin II. As we move to water depth beyond about 150m use of Gravity Base Structures (GBS) becomes very expensive or non-feasible and we need to consider other solutions. Subsea-to-beach could be an attractive solution but we need to resolve challenges related to long distance tie backs, flow assurance, uneven terrain, etc. There is also a specific need to develop floating systems capable of drilling and production in an arctic environment. To address the above technical challenges the

Contribution of Renewable Cooling to the Renewable Energy Target of the EU. Policy report

Energy Technology Data Exchange (ETDEWEB)

Kenkmann, T.; Buerger, V. [The Oeko-Institut, Freiburg (Germany)

2012-06-15

Renewable cooling technologies do not play a major role in the climate protection discussion in the European Union today. At the same time the cooling demand is expected to increase significantly in the coming decades. Renewable cooling technologies could contribute to the EU renewable energy target if an appropriate political framework for a further spread of the technologies is created. This renewable cooling policy report intends to support the dissemination of renewable cooling technologies. It provides an overview of the situation, technologies and potential for cool-ing from renewable sources and identifies key areas in which further investigation is required. The report shows that there is a great need for the creation of a political framework supporting the market diffusion of renewable cooling technologies. Firstly the question of a commonly accepted definition on renewable cooling is being addressed. Secondly renewable cooling technologies are described and the today's role of cooling in European statistics and policies is analysed. In the next step existing studies are evaluated to compare the expected development of the cooling demand in Europe to the market potential of renewable cooling. At the end of the paper a long-term vision for renewable cooling is described and first steps towards a European roadmap for renewable cooling are given.

Report on achievements in fiscal 1999. System technology to create human life compatible living environment; 1999 nendo ningen kodo tekigogata seikatsu kankyo soshutsu system gijutsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The present research and development is intended to develop the following technology: a system technology to measure, understand and accumulate human activities, analyze objectively the compatibility of human being with products and environments, and support to have the products and working environments comply with activity characteristics of individual persons (a system technology to create human life compatible living environment). Human activities are developed in various scenes, and it is not easy to structure technologies to measure, understand and support the activities common to all of the scenes. Therefore, development will be made on the technologies for measuring, understanding and supporting the activities in the human activity scenes. Development of the manipulative activity complying technology deals with human activities in the scenes to operate devices by which the activities are changed by situation identification and skills in addition to activity characteristics of individual persons. Furthermore, as a scene in which attention to the activity characteristics of individual persons, skills, and external situation is a problem, the automobile driving activities are taken up for discussion, as well as the object building work activities as a scene in which difference in skills of individuals is a problem. (NEDO)

Fusion target design

International Nuclear Information System (INIS)

Bangerter, R.O.

1978-01-01

Most detailed fusion target design is done by numerical simulation using large computers. Although numerical simulation is briefly discussed, this lecture deals primarily with the way in which basic physical arguments, driver technology considerations and economical power production requirements are used to guide and augment the simulations. Physics topics discussed include target energetics, preheat, stability and symmetry. A specific design example is discussed

Creating energy citizenship through material participation.

Science.gov (United States)

Ryghaug, Marianne; Skjølsvold, Tomas Moe; Heidenreich, Sara

2018-04-01

Transitions towards low-carbon energy systems will be comprehensive and demanding, requiring substantial public support. One important contribution from STS is to highlight the roles of citizens and public engagement. Until recently, energy users have often been treated as customers and passive market actors, or as recipients of technology at the margins of centralized systems. With respect to the latter role, critical or hesitant public action has been explained in terms of NIMBYism and knowledge deficits. This article focuses on the production of energy citizenship when considering public participation in low-carbon energy transitions. We draw upon the theory of 'material participation' to highlight how introducing and using emergent energy technologies may create new energy practices. We analyze an ongoing introduction of new material objects, highlighting the way these technologies can be seen as material interventions co-constructing temporalities of new and sustainable practices. We argue that artefacts such as the electric car, the smart meter and photovoltaic panels may become objects of participation and engagement, and that the introduction of such technologies may foster material participation and energy citizenship. The paper concludes with a discussion about the role of policies for low-carbon energy transitions on the making of energy citizenship, as well as limits of introducing a materially based energy citizenship.

Genetic technologies and ethics.

Science.gov (United States)

Ardekani, Ali M

2009-01-01

In the past decade, the human genome has been completely sequenced and the knowledge from it has begun to influence the fields of biological and social sciences in fundamental ways. Identification of about 25000 genes in the human genome is expected to create great benefits in diagnosis and treatment of diseases in the coming years. However, Genetic technologies have also created many interesting and difficult ethical issues which can affect the human societies now and in the future. Application of genetic technologies in the areas of stem cells, cloning, gene therapy, genetic manipulation, gene selection, sex selection and preimplantation diagnosis has created a great potential for the human race to influence and change human life on earth as we know it today. Therefore, it is important for leaders of societies in the modern world to pay attention to the advances in genetic technologies and prepare themselves and those institutions under their command to face the challenges which these new technologies induce in the areas of ethics, law and social policies.

CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo

Science.gov (United States)

Moreno-Mateos, Miguel A.; Vejnar, Charles E.; Beaudoin, Jean-Denis; Fernandez, Juan P.; Mis, Emily K.; Khokha, Mustafa K.; Giraldez, Antonio J.

2015-01-01

CRISPR/Cas9 technology provides a powerful system for genome engineering. However, variable activity across different single guide RNAs (sgRNAs) remains a significant limitation. We have analyzed the molecular features that influence sgRNA stability, activity and loading into Cas9 in vivo. We observe that guanine enrichment and adenine depletion increase sgRNA stability and activity, while loading, nucleosome positioning and Cas9 off-target binding are not major determinants. We additionally identified truncated and 5′ mismatch-containing sgRNAs as efficient alternatives to canonical sgRNAs. Based on these results, we created a predictive sgRNA-scoring algorithm (CRISPRscan.org) that effectively captures the sequence features affecting Cas9/sgRNA activity in vivo. Finally, we show that targeting Cas9 to the germ line using a Cas9-nanos-3′-UTR fusion can generate maternal-zygotic mutants, increase viability and reduce somatic mutations. Together, these results provide novel insights into the determinants that influence Cas9 activity and a framework to identify highly efficient sgRNAs for genome targeting in vivo. PMID:26322839

Creating an iPhone Application for Collecting Continuous ABC Data

Science.gov (United States)

Whiting, Seth W.; Dixon, Mark R.

2012-01-01

This paper provides an overview and task analysis for creating a continuous ABC data- collection application using Xcode on a Mac computer. Behavior analysts can program an ABC data collection system, complete with a customized list of target clients, antecedents, behaviors, and consequences to be recorded, and have the data automatically sent to…

Creating an Authentic Learning Environment in the Foreign Language Classroom

Science.gov (United States)

Nikitina, Larisa

2011-01-01

Theatrical activities are widely used by language educators to promote and facilitate language learning. Involving students in production of their own video or a short movie in the target language allows a seamless fusion of language learning, art, and popular culture. The activity is also conducive for creating an authentic learning situation…

Creating aesthetically resonant environments for the handicapped, elderly and rehabilitation: Sweden

DEFF Research Database (Denmark)

Brooks, Tony; Hasselblad, Stefan

2005-01-01

CARE HERE (Creating Aesthetically Resonant Environments for the Handicapped, Elderly and Rehabilitation) was realised as a full European IST (Information Society Technologies) project, involving adults and children with learning disability, PMLD (Profound and Multiple Learning Disability...

Online Experiential Education for Technological Entrepreneurs

Science.gov (United States)

Ermolovich, Thomas R.

2011-01-01

Technological Entrepreneurship is both an art and a science. As such, the education of a technological entrepreneur requires both an academic and an experiential component. One form of experiential education is creating real new ventures with student teams. When these ventures are created in an online modality, students work in virtual teams and…

New vision in fractional radiofrequency technology with switching, vacuum and cooling.

Science.gov (United States)

Elman, Monica; Gauthier, Nelly; Belenky, Inna

2015-04-01

Since the introduction of fractional technology, various systems were launched to the market. The first generation of fractional RF systems created epidermal ablation with coagulative/necrosis of the dermis with sufficient clinical outcomes, but with some limitations. The aim of this study was to evaluate the efficacy and safety of SVC technology, based on the principle of separate biological responses. Fifty-two patients were treated for 3-6 sessions using fractional RF handpiece and eight patients received combination treatments with non-invasive RF handpiece. All volunteers showed notable to significant improvement in the photoageing symptoms, without any significant complications or adverse events. Due to its wide spectrum of parameters, the SVC technology can promote different biological responses. Owing to the "Switching" technology, the control of energy depth penetration enables delivery of the necessary thermal dose to the targeted skin layer. In addition, this novel technology includes the "Vacuum" and "Cooling" mechanisms, each contributing to the safety of the treatment. The Smart Heat function reduces the necessary energy levels and thereby reduces the pain level and risks for side effects.

Technology of solid-fuel-layer targets for laser-fusion experiments

International Nuclear Information System (INIS)

Musinski, D.L.; Henderson, T.M.; Pattinson, T.R.; Tarvin, J.A.

1979-01-01

An apparatus which produces uniform solid-fuel layers in glass-shell targets for laser irradiation is described. A low-power cw laser pulse is used to vaporize the fuel within a previously frozen target which is maintained in a cold-helium environment by a cryogenic shroud. The rapid refreezing that follows the pulse forms a uniform fuel layer on the inner surface of the glass shell. This apparatus and technique meet the restrictions imposed by the experimental target chamber. The method does not perturb the target position; nor does it preclude the usual diagnostic experimets since the shroud is retracted before the main laser pulse arrives. Successful laser irradiation and implosion of solid-fuel-layer targets at KMSF have confirmed the effectiveness and reliability of this system and extended the range of laser-target-interaction studies in the cryogenic regime

Addressing key science and technology issues for IFE chambers, target fabrication and target injection

International Nuclear Information System (INIS)

Meier, W.R.; Goodin, D.T.; Nobile, A.

2003-01-01

Significant progress has been made in the development of high repetition rate chambers, target fabrication and injection for inertial fusion energy (IFE) for both heavy ion and laser drivers. Research is being conducted in a coordinated manner by national laboratories, universities and industry. This paper provides an overview of U.S. research activities and discusses how interface considerations (such as beam propagation and target survival during injection) impact design choices. (author)

Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.

Directory of Open Access Journals (Sweden)

Sisse B Ditlev

Full Text Available Placental malaria is a major health problem for both pregnant women and their fetuses in malaria endemic regions. It is triggered by the accumulation of Plasmodium falciparum-infected erythrocytes (IE in the intervillous spaces of the placenta and is associated with foetal growth restriction and maternal anemia. IE accumulation is supported by the binding of the parasite-expressed protein VAR2CSA to placental chondroitin sulfate A (CSA. Defining specific CSA-binding epitopes of VAR2CSA, against which to target the immune response, is essential for the development of a vaccine aimed at blocking IE adhesion. However, the development of a VAR2CSA adhesion-blocking vaccine remains challenging due to (i the large size of VAR2CSA and (ii the extensive immune selection for polymorphisms and thereby non-neutralizing B-cell epitopes. Camelid heavy-chain-only antibodies (HcAbs are known to target epitopes that are less immunogenic to classical IgG and, due to their small size and protruding antigen-binding loop, able to reach and recognize cryptic, conformational epitopes which are inaccessible to conventional antibodies. The variable heavy chain (VHH domain is the antigen-binding site of camelid HcAbs, the so called Nanobody, which represents the smallest known (15 kDa intact, native antigen-binding fragment. In this study, we have used the Nanobody technology, an approach new to malaria research, to generate small and functional antibody fragments recognizing unique epitopes broadly distributed on VAR2CSA.

Education, Technology and Health Literacy.

Science.gov (United States)

Lindgren, Kurt; Koldkjær Sølling, Ina; Carøe, Per; Siggaard Mathiesen, Kirsten

2015-01-01

The purpose of this study is to develop an interdisciplinary learning environment between education in technology, business, and nursing. This collaboration creates natural interest and motivation for welfare technology. The aim of establishing an interaction between these three areas of expertise is to create an understanding of skills and cultural differences in each area. Futhermore, the aim is to enable future talents to gain knowledge and skills to improve health literacy among senior citizens. Based on a holistic view of welfare technology, a Student Academy was created as a theoretically- and practically-oriented learning center. The mission of the Student Academy is to support and facilitate education in order to maintain and upgrade knowledge and skills in information technology and information management related to e-health and health literacy. The Student Academy inspires students, stakeholders, politicians, DanAge Association members, companies, and professionals to participate in training, projects, workshops, and company visits.

Acquisition Modernization: Transitioning Technology Into Warfighter Capability

Science.gov (United States)

2011-08-01

to test and evaluate the technology and integrate the new capability into operational weapon systems (Figure 4). This funding model creates stove...misalignment between missions, TRLs, and the RDT&E funding model is a major 11 contributor to the valley of death. Technologies become obsolete on... funding model of the acquisition system. Create an individual budget account to fund the development of promising technologies. The Acquisition

What Is Educational Technology? An Inquiry into the Meaning, Use, and Reciprocity of Technology

Science.gov (United States)

Lakhana, Arun

2014-01-01

This position paper explores the ambiguity of technology, toward refined understanding of Educational Technology. The purpose of education is described by John Dewey as growing, or habitual learning. Two philosophical conceptions of technology are reviewed. Dewey positions inquiry as a technology that creates knowledge. Val Dusek offers a…

Design incentives to increase vehicle size created from the U.S. footprint-based fuel economy standards

International Nuclear Information System (INIS)

Whitefoot, Kate S.; Skerlos, Steven J.

2012-01-01

The recently amended U.S. Corporate Average Fuel Economy (CAFE) standards determine fuel-economy targets based on the footprint (wheelbase by track width) of vehicles such that larger vehicles have lower fuel-economy targets. This paper considers whether these standards create an incentive for firms to increase vehicle size by presenting an oligopolistic-equilibrium model in which automotive firms can modify vehicle dimensions, implement fuel-saving technology features, and trade off acceleration performance and fuel economy. Wide ranges of scenarios for consumer preferences are considered. Results suggest that the footprint-based CAFE standards create an incentive to increase vehicle size except when consumer preference for vehicle size is near its lower bound and preference for acceleration is near its upper bound. In all other simulations, the sales-weighted average vehicle size increases by 2–32%, undermining gains in fuel economy by 1–4 mpg (0.6–1.7 km/L). Carbon-dioxide emissions from these vehicles are 5–15% higher as a result (4.69×10 11 –5.17×10 11 kg for one year of produced vehicles compared to 4.47×10 11 kg with no size changes), which is equivalent to adding 3–10 coal-fired power plants to the electricity grid each year. Furthermore, results suggest that the incentive is larger for light trucks than for passenger cars, which could increase traffic safety risks. - Highlights: ► New U.S. fuel-economy standards may create an incentive to increase vehicle size. ► We model firms as choosing vehicle designs and prices in oligopolistic equilibrium. ► Vehicle size increases 2–32% for 20 out of 21 scenarios of consumer preferences. ► Increases in size reduce fuel economy gains from 5–13%, resulting in 5–15% higher CO 2 emissions. ► Incentive is larger for trucks than cars, which may increase traffic safety risks.

Accelerator and spallation target technologies for ADS applications

International Nuclear Information System (INIS)

2005-01-01

The efficient and safe management of spent fuel produced during the operation of commercial nuclear power plants is an important issue. Worldwide, more than 250 000 tons of spent fuel from reactors currently operating will require disposal. These numbers account for only high-level radio-active waste generated by present-day power reactors. Nearly all issues related to risks to future generations arising from the long-term disposal of such spent nuclear fuel is attributable to only about 1% of its content. This 1% is made up primarily of plutonium, neptunium, americium and curium (called transuranic elements) and the long-lived isotopes of iodine and technetium. When transuranics are removed from discharged fuel destined for disposal, the toxic nature of the spent fuel drops below that of natural uranium ore (that which was originally mined for the nuclear fuel) within a period of several hundred years. This significantly reduces the burden on geological repositories and the problem of addressing the remaining long-term residues can thus be done in controlled environments having timescales of centuries rather than millennia. To address the disposal of transuranics, accelerator-driven systems (ADS), i.e. a sub-critical system driven by an accelerator to sustain the chain reaction, seem to have great potential for transuranic transmutation, though much R and D work is still required in order to demonstrate their desired capability as a whole system. This report describes the current status of accelerator and spallation target technologies and suggests technical issues that need to be resolved for ADS applications. It will be of particular interest to nuclear scientists involved in ADS development and in advanced fuel cycles in general. (author)

Achievement report for fiscal 1998. Research and development of technologies for creating new bioaffinity molecules using submicron beads (Energy use rationalization related technology practicalization); 1998 nendo biryushi riyogata seitai ketsugo busshitsunado sosei gijutsu no kenkyu kaihatsu seika hokokusho. Energy shiyo gorika kankei gijutsu jitsuyoka kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

In the effort to develop chemical substance/bioreceptor analysis technology using submicron beads, polystyrene core/polyglycidyl methacrilate beads are used in a study started about a detachable spacer using newly developed fixation technology. In the development of bioaffinity chemical substance refining technology, two kinds of sugars and several kinds of aromatic aldehydes serve as building blocks in the construction of a library, and studies are made of analyses using liquid chromatography and mass spectrography. In the development of novel substance creation technology based on information on the analysis of chemical substance/bioreceptor, in an effort at developing technologies for creating novel function provided chemical substances, heterocyclic compounds, alkaloids, and sugar compounds are selected and their syntheses in the liquid phase and solid phase are studied, which is again for the construction of a library. (NEDO)

Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.

Science.gov (United States)

Tareen, Semih U; Kelley-Clarke, Brenna; Nicolai, Christopher J; Cassiano, Linda A; Nelson, Lisa T; Slough, Megan M; Vin, Chintan D; Odegard, Jared M; Sloan, Derek D; Van Hoeven, Neal; Allen, James M; Dubensky, Thomas W; Robbins, Scott H

2014-03-01

As sentinels of the immune system, dendritic cells (DCs) play an essential role in regulating cellular immune responses. One of the main challenges of developing DC-targeted therapies includes the delivery of antigen to DCs in order to promote the activation of antigen-specific effector CD8 T cells. With the goal of creating antigen-directed immunotherapeutics that can be safely administered directly to patients, Immune Design has developed a platform of novel integration-deficient lentiviral vectors that target and deliver antigen-encoding nucleic acids to human DCs. This platform, termed ID-VP02, utilizes a novel genetic variant of a Sindbis virus envelope glycoprotein with posttranslational carbohydrate modifications in combination with Vpx, a SIVmac viral accessory protein, to achieve efficient targeting and transduction of human DCs. In addition, ID-VP02 incorporates safety features in its design that include two redundant mechanisms to render ID-VP02 integration-deficient. Here, we describe the characteristics that allow ID-VP02 to specifically transduce human DCs, and the advances that ID-VP02 brings to conventional third-generation lentiviral vector design as well as demonstrate upstream production yields that will enable manufacturing feasibility studies to be conducted.

Clearing the fog of anticancer patents from 1993-2013: through an in-depth technology landscape & target analysis from pioneer research institutes and universities worldwide.

Science.gov (United States)

Dara, Ajay; Sangamwar, Abhay T

2014-01-01

In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR): India's largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade anticancer scenario with respect to top public funded universities worldwide.

Ultramild protein-mediated click chemistry creates efficient oligonucleotide probes for targeting and detecting nucleic acids

DEFF Research Database (Denmark)

Nåbo, Lina J.; Madsen, Charlotte S.; Jensen, Knud J.

2015-01-01

Functionalized synthetic oligonucleotides are finding growing applications in research, clinical studies, and therapy. However, it is not easy to prepare them in a biocompatible and highly efficient manner. We report a new strategy to synthesize oligonucleotides with promising nucleic acid...... targeting and detection properties. We focus in particular on the pH sensitivity of these new probes and their high target specificity. For the first time, human copper(I)-binding chaperon Cox17 was applied to effectively catalyze click labeling of oligonucleotides. This was performed under ultramild...... conditions with fluorophore, peptide, and carbohydrate azide derivatives. In thermal denaturation studies, the modified probes showed specific binding to complementary DNA and RNA targets. Finally, we demonstrated the pH sensitivity of the new rhodamine-based fluorescent probes in vitro and rationalize our...

Federal Technology Transfer Act Success Stories

Science.gov (United States)

Successful Federal Technology Transfer Act (FTTA) partnerships demonstrate the many advantages of technology transfer and collaboration. EPA and partner organizations create valuable and applicable technologies for the marketplace.

Developing Ethical Guidelines for Creating Social Media Technology Policy in Social Work Classrooms

OpenAIRE

Shane R. Brady; David A. McLeod; Jimmy A. Young

2015-01-01

This paper will discuss social media technology in the context of social work education. While social media technology is prevalent in social work education, most discourse about ethical use of social media in the classroom has taken a prescriptive and overly cautious approach that neglects the context dependent nature that social work educators teach in as well as the overwhelmingly positive potential of social media technology in the classroom. This paper utilizes social constructivist theo...

HTML5 games creating fun with HTML5, CSS3, and WebGL

CERN Document Server

Seidelin, Jacob

2011-01-01

Discover new opportunities for building 2D and 3D games with HTML5 The newest iteration of HTML, HTML5 can be used with JavaScript, CSS3, and WebGL to create beautiful, unique, engaging games that can be played on the web or mobile devices like the iPad or Android phones. Gone are the days where games were only possible with plugin technologies such as Flash and this cutting-edge book shows you how to utilize the latest open web technologies to create a game from scratch using Canvas, HTML5 Audio, WebGL, and WebSockets. You'll discover how to build a framework on which you will create your HTML5 game. Then each successive chapter covers a new aspect of the game, including user input, sound, multiplayer functionality, 2D and 3D graphics, and more. Aims directly at a new way to develop games for the web through the use of HTML5 Demonstrates how to make iOS and Android web apps Explains how to capture player input; create 3D graphics; and incorporate textures, lighting, and sound Guides you through the proce...

Creating a climate that catalyses healthcare innovation in the United Kingdom – learning lessons from international innovators

Directory of Open Access Journals (Sweden)

Kathrin Cresswell

2017-01-01

Conclusions:  There is now a need to create mechanisms through which frontline National Health Service staff in relation can raise ideas/concerns and suggest opportunities for improvement, and then build national innovation environments that seek to address these needs. This should be accompanied by creating competitive health technology markets to stimulate a commercial environment that attracts high-quality health information technology experts and innovators working in partnership with staff and patients.

The effect of target and non-target similarity on neural classification performance: A boost from confidence

OpenAIRE

Amar R Marathe; Anthony J Ries; Vernon J Lawhern; Vernon J Lawhern; Brent J Lance; Jonathan eTouryan; Kaleb eMcDowell; Hubert eCecotti

2015-01-01

Brain computer interaction (BCI) technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in si...

The effect of target and non-target similarity on neural classification performance: a boost from confidence

OpenAIRE

Marathe, Amar R.; Ries, Anthony J.; Lawhern, Vernon J.; Lance, Brent J.; Touryan, Jonathan; McDowell, Kaleb; Cecotti, Hubert

2015-01-01

Brain computer interaction (BCI) technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in si...

Creating technical heritage object replicas in a virtual environment

Science.gov (United States)

Egorova, Olga; Shcherbinin, Dmitry

2016-03-01

The paper presents innovative informatics methods for creating virtual technical heritage replicas, which are of significant scientific and practical importance not only to researchers but to the public in general. By performing 3D modeling and animation of aircrafts, spaceships, architectural-engineering buildings, and other technical objects, the process of learning is achieved while promoting the preservation of the replicas for future generations. Modern approaches based on the wide usage of computer technologies attract a greater number of young people to explore the history of science and technology and renew their interest in the field of mechanical engineering.

Application of real-time single camera SLAM technology for image-guided targeting in neurosurgery

Science.gov (United States)

Chang, Yau-Zen; Hou, Jung-Fu; Tsao, Yi Hsiang; Lee, Shih-Tseng

2012-10-01

In this paper, we propose an application of augmented reality technology for targeting tumors or anatomical structures inside the skull. The application is a combination of the technologies of MonoSLAM (Single Camera Simultaneous Localization and Mapping) and computer graphics. A stereo vision system is developed to construct geometric data of human face for registration with CT images. Reliability and accuracy of the application is enhanced by the use of fiduciary markers fixed to the skull. The MonoSLAM keeps track of the current location of the camera with respect to an augmented reality (AR) marker using the extended Kalman filter. The fiduciary markers provide reference when the AR marker is invisible to the camera. Relationship between the markers on the face and the augmented reality marker is obtained by a registration procedure by the stereo vision system and is updated on-line. A commercially available Android based tablet PC equipped with a 320×240 front-facing camera was used for implementation. The system is able to provide a live view of the patient overlaid by the solid models of tumors or anatomical structures, as well as the missing part of the tool inside the skull.

Final Report for Bio-Inspired Approaches to Moving-Target Defense Strategies

Energy Technology Data Exchange (ETDEWEB)

Fink, Glenn A.; Oehmen, Christopher S.

2012-09-01

This report records the work and contributions of the NITRD-funded Bio-Inspired Approaches to Moving-Target Defense Strategies project performed by Pacific Northwest National Laboratory under the technical guidance of the National Security Agency’s R6 division. The project has incorporated a number of bio-inspired cyber defensive technologies within an elastic framework provided by the Digital Ants. This project has created the first scalable, real-world prototype of the Digital Ants Framework (DAF)[11] and integrated five technologies into this flexible, decentralized framework: (1) Ant-Based Cyber Defense (ABCD), (2) Behavioral Indicators, (3) Bioinformatic Clas- sification, (4) Moving-Target Reconfiguration, and (5) Ambient Collaboration. The DAF can be used operationally to decentralize many such data intensive applications that normally rely on collection of large amounts of data in a central repository. In this work, we have shown how these component applications may be decentralized and may perform analysis at the edge. Operationally, this will enable analytics to scale far beyond current limitations while not suffering from the bandwidth or computational limitations of centralized analysis. This effort has advanced the R6 Cyber Security research program to secure digital infrastructures by developing a dynamic means to adaptively defend complex cyber systems. We hope that this work will benefit both our client’s efforts in system behavior modeling and cyber security to the overall benefit of the nation.

Persist in creating of science and technology (S.T.), promote the development of uranium exploration

International Nuclear Information System (INIS)

Du Letian; Yu Dagan

2002-01-01

The modern social production is characterized by high-grade S.T. leading, the guarantee of which are the creating and recreating. Creating is comprehensive, including the thinking, concepts, view points, theories, systems, management, S.T., engineering, etc. The prospecting and exploration of uranium deposits in China also must follow this trend by renewing the strategies, the management system, S.T. studies, the thinking fashion for more, faster, better, finding uranium deposits

Creating Better Library Information Systems: The Road to FRBR-Land

Science.gov (United States)

Mercun, Tanja; Švab, Katarina; Harej, Viktor; Žumer, Maja

2013-01-01

Introduction: To provide valuable services in the future, libraries will need to create better information systems and set up an infrastructure more in line with the current technologies. The "Functional Requirements for Bibliographic Records" conceptual model provides a basis for this transformation, but there are still a number of…

Creating Visual Design and Meaningful Audience Experiences

DEFF Research Database (Denmark)

Steijn, Arthur; Ion Wille, Jakob

2014-01-01

The main purpose of the EU Interreg funded Classical Composition Music and Experience Design project, was to rethink audience experiences and develop knowledge of applied technologies connected to classical music and live concerts. The project and its main objectives was motivated by at least thee...... conditions. The most important being 1) the development in new technology creating new expectations in audiences attending cultural events, including classical concerts, 2) resent decline in audiences attending classical music and 3) a will to strengthen relations between cultural institutions, creative...... businesses and educational institutions in the Øresund region (including the city and surroundings of Malmø and Copenhagen). Therefore the project Classical Composition Music and Experience Design focused on developing new and meaningful audience experiences where live classical music meets new digital...

FY 2000 report on the results of the research and development project for new industry creation type industrial science technologies. Cluster ion beam process technology; 2000 nendo shinki sangyo soshutsugata sangyo kagaku gijutsu kenkyu kaihatsu seido seika hokokusho. Cluster ion beam process technology

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Described herein are the FY 2000 results of development of cluster ion beams. This technology generates the strong ion beams of atom and molecule clusters, and irradiate them onto the solid surfaces, to create new materials or treat materials. It allows the nano-level treatment. The program for high-current cluster ion beam generation/irradiation technology for industrial purposes attains the target high-current beam of 500{mu}m. It is necessary to establish the optimum cluster size, irradiated energy and ion species for the highly functional surface treatment, for which applicable technologies, e.g., those related to time of flight and molecular dynamics, are developed. Studies on high-current, large-area irradiation technologies are started. The program for material processing technologies involves evaluation of crystalline defects formed during the beam implantation by photoluminescence spectroscopy, and studies on semiconductor surface processing technologies. The surface smoothening technology is investigated to reduce crystalline defects and stress-induced strains for difficult-to-process materials, e.g., SiC and diamond, and the good results are produced. The program for development of superflat/superhard thin film formation technology involves irradiation of the Ar ion beams during the deposition of C{sub 60}(fullerene), to produce the superhard thin film. (NEDO)

CREATE-IP and CREATE-V: Data and Services Update

Science.gov (United States)

Carriere, L.; Potter, G. L.; Hertz, J.; Peters, J.; Maxwell, T. P.; Strong, S.; Shute, J.; Shen, Y.; Duffy, D.

2017-12-01

The NASA Center for Climate Simulation (NCCS) at the Goddard Space Flight Center and the Earth System Grid Federation (ESGF) are working together to build a uniform environment for the comparative study and use of a group of reanalysis datasets of particular importance to the research community. This effort is called the Collaborative REAnalysis Technical Environment (CREATE) and it contains two components: the CREATE-Intercomparison Project (CREATE-IP) and CREATE-V. This year's efforts included generating and publishing an atmospheric reanalysis ensemble mean and spread and improving the analytics available through CREATE-V. Related activities included adding access to subsets of the reanalysis data through ArcGIS and expanding the visualization tool to GMAO forecast data. This poster will present the access mechanisms to this data and use cases including example Jupyter Notebook code. The reanalysis ensemble was generated using two methods, first using standard Python tools for regridding, extracting levels and creating the ensemble mean and spread on a virtual server in the NCCS environment. The second was using a new analytics software suite, the Earth Data Analytics Services (EDAS), coupled with a high-performance Data Analytics and Storage System (DASS) developed at the NCCS. Results were compared to validate the EDAS methodologies, and the results, including time to process, will be presented. The ensemble includes selected 6 hourly and monthly variables, regridded to 1.25 degrees, with 24 common levels used for the 3D variables. Use cases for the new data and services will be presented, including the use of EDAS for the backend analytics on CREATE-V, the use of the GMAO forecast aerosol and cloud data in CREATE-V, and the ability to connect CREATE-V data to NCCS ArcGIS services.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Science.gov (United States)

Herce, Henry D; Schumacher, Dominik; Schneider, Anselm F L; Ludwig, Anne K; Mann, Florian A; Fillies, Marion; Kasper, Marc-André; Reinke, Stefan; Krause, Eberhard; Leonhardt, Heinrich; Cardoso, M Cristina; Hackenberger, Christian P R

2017-08-01

Functional antibody delivery in living cells would enable the labelling and manipulation of intracellular antigens, which constitutes a long-thought goal in cell biology and medicine. Here we present a modular strategy to create functional cell-permeable nanobodies capable of targeted labelling and manipulation of intracellular antigens in living cells. The cell-permeable nanobodies are formed by the site-specific attachment of intracellularly stable (or cleavable) cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain VHH antibody fragments. We used this strategy for the non-endocytic delivery of two recombinant nanobodies into living cells, which enabled the relocalization of the polymerase clamp PCNA (proliferating cell nuclear antigen) and tumour suppressor p53 to the nucleolus, and thereby allowed the detection of protein-protein interactions that involve these two proteins in living cells. Furthermore, cell-permeable nanobodies permitted the co-transport of therapeutically relevant proteins, such as Mecp2, into the cells. This technology constitutes a major step in the labelling, delivery and targeted manipulation of intracellular antigens. Ultimately, this approach opens the door towards immunostaining in living cells and the expansion of immunotherapies to intracellular antigen targets.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

Science.gov (United States)

Herce, Henry D.; Schumacher, Dominik; Schneider, Anselm F. L.; Ludwig, Anne K.; Mann, Florian A.; Fillies, Marion; Kasper, Marc-André; Reinke, Stefan; Krause, Eberhard; Leonhardt, Heinrich; Cardoso, M. Cristina; Hackenberger, Christian P. R.

2017-08-01

Functional antibody delivery in living cells would enable the labelling and manipulation of intracellular antigens, which constitutes a long-thought goal in cell biology and medicine. Here we present a modular strategy to create functional cell-permeable nanobodies capable of targeted labelling and manipulation of intracellular antigens in living cells. The cell-permeable nanobodies are formed by the site-specific attachment of intracellularly stable (or cleavable) cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain VHH antibody fragments. We used this strategy for the non-endocytic delivery of two recombinant nanobodies into living cells, which enabled the relocalization of the polymerase clamp PCNA (proliferating cell nuclear antigen) and tumour suppressor p53 to the nucleolus, and thereby allowed the detection of protein-protein interactions that involve these two proteins in living cells. Furthermore, cell-permeable nanobodies permitted the co-transport of therapeutically relevant proteins, such as Mecp2, into the cells. This technology constitutes a major step in the labelling, delivery and targeted manipulation of intracellular antigens. Ultimately, this approach opens the door towards immunostaining in living cells and the expansion of immunotherapies to intracellular antigen targets.

Reviews on laser cutting technology for industrial applications

Science.gov (United States)

Muangpool, T.; Pullteap, S.

2018-03-01

In this paper, an overview of the laser technology applied for the industrial has been reviewed. In general, this technology was used in several engineering applications such as industrial, medical, science, research sectors, etc. Focusing on the laser technology in the industrial section, it was, normally, employed for many purposes i.e. target marking, welding, drilling, and also cutting. Consequently, the laser cutting technology was, however, divided into three classifications YAG, CO2, and fiber laser, respectively. Each laser types have different advantages and disadvantages depending on the material type. The advantages by using laser cutting compared with the general cutting machines were exploited in terms of narrow kerf, high cutting speed, low heat-affected zone (HAZ), improve efficiency of the cutting process, high accuracy, etc. However, the main objectives from the technology used were increasing of the products and also decreasing the production cost. In the opposite way, some disadvantages of the technology were summarized by complexity to operate, high maintenance cost, and also high power consumption. In Thailand industry, there were many factories used this technology as a cutting process. Unfortunately, only few researches were published. It might explains that this technology were difficulty to develop, high investment, and also easy to import from aboard. For becoming to the Thailand 4.0 community, the Thailand industry might awareness to reduce the importing machine and boosting some policies to create novel innovative / know-how from the own country.

Technological Literacy for All: A Course Designed to Raise the Technological Literacy of College Students

Science.gov (United States)

Baskette, Kimberly G.; Fantz, Todd D.

2013-01-01

Understanding what technology is, and is not, is the first step in becoming technologically literate. One should also understand how technology is created, how it works, how it shapes society, and how society shapes technology. This study was designed to gauge the ability of a single-semester course to raise students' technological literacy as…

Tobacco advertisements targeted on women: creating an awareness among women.

Science.gov (United States)

Kaleta, Dorota; Usidame, Bukola; Polańska, Kinga

2011-06-01

It has been always believed that men smoke more than women, but the trend of smoking in women is increasing nowadays. In some countries there are even more female smokers than male smokers. This is a major health risk because women are present and future mothers, and increasing number of smoking women will enlarge the number of exposed children. Relatively few women are aware of gender-specific health risks, including cervical cancer, osteoporosis, poor pregnancy outcome and early menopause. Tobacco related diseases are on the rise in women, considering the fact that more women now die of lung cancer than breast cancer. Tobacco companies have invented various ways to target women through tobacco advertising despite the various bans. This inevitably leads to the increase in female smoking rates. There are various recommendations from the World Health Organization which include the need for governments to pay particular attention to protect women from the tobacco companies' attempts to lure them into lifetimes of nicotine dependence and to take up counter advertisements against the tobacco companies.

Infrared small target detection technology based on OpenCV

Science.gov (United States)

Liu, Lei; Huang, Zhijian

2013-09-01

Accurate and fast detection of infrared (IR) dim target has very important meaning for infrared precise guidance, early warning, video surveillance, etc. In this paper, some basic principles and the implementing flow charts of a series of algorithms for target detection are described. These algorithms are traditional two-frame difference method, improved three-frame difference method, background estimate and frame difference fusion method, and building background with neighborhood mean method. On the foundation of above works, an infrared target detection software platform which is developed by OpenCV and MFC is introduced. Three kinds of tracking algorithms are integrated in this software. In order to explain the software clearly, the framework and the function are described in this paper. At last, the experiments are performed for some real-life IR images. The whole algorithm implementing processes and results are analyzed, and those algorithms for detection targets are evaluated from the two aspects of subjective and objective. The results prove that the proposed method has satisfying detection effectiveness and robustness. Meanwhile, it has high detection efficiency and can be used for real-time detection.

X-ray spectroscopy of plasmas created by the Nike KrF laser

International Nuclear Information System (INIS)

Aglitskiy, Y.; Lehecka, T.; Deniz, A.; Hardgrove, J.; Seely, J.; Brown, C.; Feldman, U.; Pawley, C.; Gerber, K.; Bodner, S.; Obenschain, S.; Lehmberg, R.; McLean, E.; Pronko, M.; Sethian, J.; Stamper, J.; Schmitt, A.; Sullivan, C.; Holland, G.; Laming, M.

1997-01-01

The x-ray emission from plasmas created by the Naval Research Laboratory Nike KrF laser was characterized using spectroscopic instruments. The targets were thin foils of aluminum and titanium and were irradiated by laser energies in the range 100 endash 1500 J. Using a spherical-crystal imaging spectrometer operating in the 1 endash 2 keV x-ray region, the density, temperature, and opacity of aluminum plasmas were determined with a spatial resolution of 10 μm in the direction perpendicular to the target surface. The spectral line ratios indicated that the aluminum plasmas were relatively dense, cool, and optically thick near the target surface

Clearing the fog of anticancer patents from 1993-2013: through an in-depth technology landscape & target analysis from pioneer research institutes and universities worldwide.

Directory of Open Access Journals (Sweden)

Ajay Dara

Full Text Available BACKGROUND: In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR: India's largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. METHODOLOGY/PRINCIPAL FINDINGS: The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. CONCLUSIONS/SIGNIFICANCE: The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade

The Center for Environmental Technology Innovative Technology Screening Process

International Nuclear Information System (INIS)

Bertrand, C.M.

1995-02-01

The Center for Environmental Technology's (CET) mission is to provide a fully integrated system for accelerated evaluation, development, commercialization, and public acceptance of creative environmental solutions which match the foremost demands in today's environmentally sensitive world. In short, CET will create a means to provide quick, effective solutions for environmental needs. To meet this mission objective, CET has created a unique and innovative approach to eliminating the usual barriers in developing and testing environmental technologies. The approach paves the way for these emerging, cutting-edge technologies by coordinating environmental restoration and waste management activities of industry, universities, and the government to: efficiently and effectively transfer technology to these users, provide market-driven, cost-effective technology programs to the public and DOE, and aid in developing innovative ideas by initiating efforts between DOE facilities and private industry. The central part to this mission is selecting and evaluating specific innovative technologies for demonstration and application at United States Department of Energy (DOE) installations. The methodology and criteria used for this selection, which is called the CET Innovative Technology Screening Process, is the subject of this paper. The selection criteria used for the screening process were modeled after other DOE technology transfer programs and were further developed by CET's Technology Screening and Evaluation Board (TSEB). The process benefits both CET and the proposing vendors by providing objective selection procedures based on predefined criteria. The selection process ensures a rapid response to proposing vendors, all technologies will have the opportunity to enter the selection process, and all technologies are evaluated on the same scale and with identical criteria

Induced mutation and epigenetics modification in plants for crop improvement by targeting CRISPR/Cas9 technology.

Science.gov (United States)

Khan, Muhammad Hafeez Ullah; Khan, Shahid U; Muhammad, Ali; Hu, Limin; Yang, Yang; Fan, Chuchuan

2018-06-01

Clustered regularly interspaced palindromic repeats associated protein Cas9 (CRISPR-Cas9), originally an adaptive immunity system of prokaryotes, is revolutionizing genome editing technologies with minimal off-targets in the present era. The CRISPR/Cas9 is now highly emergent, advanced, and highly specific tool for genome engineering. The technology is widely used to animal and plant genomes to achieve desirable results. The present review will encompass how CRISPR-Cas9 is revealing its beneficial role in characterizing plant genetic functions, genomic rearrangement, how it advances the site-specific mutagenesis, and epigenetics modification in plants to improve the yield of field crops with minimal side-effects. The possible pitfalls of using and designing CRISPR-Cas9 for plant genome editing are also discussed for its more appropriate applications in plant biology. Therefore, CRISPR/Cas9 system has multiple benefits that mostly scientists select for genome editing in several biological systems. © 2017 Wiley Periodicals, Inc.

The use of smart technologies in enabling construction components reuse: A viable method or a problem creating solution?

Science.gov (United States)

Iacovidou, Eleni; Purnell, Phil; Lim, Ming K

2018-06-15

The exploitation of Radio Frequency Identification (RFID) for tracking and archiving the properties of structural construction components could be a potentially innovative disruption for the construction sector. This is because RFID can stimulate the reuse of construction components and reduce their wastage, hence addressing sustainability issues in the construction sector. To test the plausibility of that idea, this study explores the potential pre-conditions for RFID to facilitate construction components reuse, and develops a guidance for promoting their redistribution back to the supply chain. It also looks at how integrating RFID with Building Information Modelling (BIM) can possibly be a valuable extension of its capabilities, providing the opportunity for tracked components to be incorporated into new structures in an informed, sound way. A preliminary assessment of the strengths, weaknesses, opportunities and threats of the RFID technology is presented in order to depict its current and future potential in promoting construction components' sustainable lifecycle management, while emphasis has been laid on capturing their technical, environmental, economic and social value. Findings suggest that the collection of the right amount of information at the design-construction-deconstruction-reuse-disposal stage is crucial for RFID to become a successful innovation in the construction sector. Although a number of limitations related to the technical operability and recycling of RFID tags seem to currently hinder its uptake for structural components' lifecycle management, future technological innovations could provide solutions that would enable it to become a mainstream practice. Taken together these proposals advocate that the use of RFID and its integration with BIM can create the right environment for the development of new business models focused on sustainable resource management. These models may then unlock multiple values that are otherwise dissipated in

Factors Affecting Use of Telepresence Technology in a Global Technology Company

Science.gov (United States)

Agnor, Robert Joseph

2013-01-01

Telepresence uses the latest video conferencing technology, with high definition video, surround sound audio, and specially constructed studios, to create a near face-to-face meeting experience. A Fortune 500 company which markets information technology has organizations distributed around the globe, and has extensive collaboration needs among…

Mobile Workforce, Mobile Technology, Mobile Threats

International Nuclear Information System (INIS)

Garcia, J.

2015-01-01

Mobile technologies' introduction into the world of safeguards business processes such as inspection creates tremendous opportunity for novel approaches and could result in a number of improvements to such processes. Mobile applications are certainly the wave of the future. The success of the application ecosystems has shown that users want full fidelity, highly-usable, simple purpose applications with simple installation, quick responses and, of course, access to network resources at all times. But the counterpart to opportunity is risk, and the widespread adoption of mobile technologies requires a deep understanding of the threats and vulnerabilities inherent in mobile technologies. Modern mobile devices can be characterized as small computers. As such, the threats against computing infrastructure apply to mobile devices. Meanwhile, the attributes of mobile technology that make it such an obvious benefit over traditional computing platforms all have elements of risk: pervasive, always-on networking; diverse ecosystems; lack of centralized control; constantly shifting technological foundations; intense competition among competitors in the marketplace; the scale of the installation base (from millions to billions); and many more. This paper will explore the diverse and massive environment of mobile, the number of attackers and vast opportunities for compromise. The paper will explain how mobile devices prove valuable targets to both advanced and persistent attackers as well as less-skilled casual hackers. Organized crime, national intelligence agencies, corporate espionage are all part of the landscape. (author)

Design of the MYRRHA Spallation Target Assembly

International Nuclear Information System (INIS)

Keijers, S.; Fernandez, R.; Stankovskiy, A.; Kennedy, G.; Van Tichelen, K.

2015-01-01

MYRRHA (Multi-purpose hybrid Research Reactor for High-tech Applications) is a multi-purpose research facility currently being developed at SCK.CEN. MYRRHA is based on the ADS (Accelerator Driven System) concept where a proton accelerator, a spallation target and a subcritical reactor are coupled. MYRRHA will demonstrate the ADS full concept by coupling these three components at a reasonable power level. As a flexible irradiation facility, the MYRRHA research reactor will be able to work in both critical and subcritical modes. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material research for GEN IV and fusion reactors, and radioisotope production for medical and industrial applications. MYRRHA will be cooled by Lead Bismuth Eutectic (LBE) and will play an important role in the development of the Pb-alloys technology needed for the LFR (Lead Fast Reactor) GEN IV concept. This paper describes the evolution of the MYRRHA spallation target design. In the early phase of the MYRRHA project (XT-ADS), the target design was based on a dedicated spallation loop inside the primary reactor vessel. Within the core, the 3 central fuel assembly positions were occupied by the spallation target, which enabled a windowless design created by a free surface of LBE facing the proton beam. The windowless option was preferred because of high heat loads in combination with severe irradiation damage in the target region would result in unacceptably short lifetimes of a target window. The LBE in the loop served as spallation target and as target coolant, but was separated from the LBE cooling the reactor core. The loop was equipped with its own pump, heat exchanger and conditioning system. The change from cyclotron to linear accelerator allowed the increase in proton energy from 350 MeV to 600 MeV. This modification led to an important reduction of the specific heat load at the target level and an improvement of the neutronic performance. In addition to

SedMob: A mobile application for creating sedimentary logs in the field

Science.gov (United States)

Wolniewicz, Pawel

2014-05-01

SedMob is an open-source, mobile software package for creating sedimentary logs, targeted for use in tablets and smartphones. The user can create an unlimited number of logs, save data from each bed in the log as well as export and synchronize the data with a remote server. SedMob is designed as a mobile interface to SedLog: a free multiplatform package for drawing graphic logs that runs on PC computers. Data entered into SedMob are saved in the CSV file format, fully compatible with SedLog.

Workshop: Creating Your Institutional Research Repository

KAUST Repository

Grenz, Daryl M.

2016-11-08

In 2002, the Scholarly Publishing and Academic Resources Coalition (SPARC) proposed the concept of an institutional repository to simultaneously disrupt and enhance the state of scholarly communications in the academic world. Thirteen years later, thousands of universities and other institutions have answered this call, but many more have not due to gaps in budgets, awareness and, most of all, practical guidance on creating an institutional repository. This workshop provides you with an essential primer on what it takes to establish a fully-functioning institutional repository. Every aspect of the process will be covered, including policies, procedures, staffing guidelines, workflows and repository technologies.

Network technology for depot modernization

Energy Technology Data Exchange (ETDEWEB)

Hostick, C.J.

1990-12-01

This report was prepared by the Pacific Northwest Laboratory to summarize existing and emerging information system technology and standards applicable to Depot System Command (DESCOM) modernization efforts. The intent of this summarization is to provide the Revitalization of Army Depots for the Year 2000 (READY 2000) team a clear understanding of the enabling information system technologies required to support effective modernization activities. Much of the information contained in this report was acquired during the last year in support of the US Army Armament, Munitions, and Chemical Command (AMCCOM) Facility Integrated Manufacturing Management System (FIMMS) project at PNL, which is targeting the modernization of plant-wide information systems at Army Ammunition Plants. The objective of information system modernization is to improve the effectiveness of an organization in performing its mission. Information system modernization strives to meet this objective by creating an environment where data is electronically captured near the source and readily available to all areas of the organization. Advanced networks, together with related information system technology, are the enabling mechanisms that make modern information system infrastructures possible. The intent of this paper is to present an overview of advanced information system network technology to support depot modernization planners in making technology management decisions. Existing and emerging Open System Interconnection (OSI) and Government Open System Interconnection Profile (GOSIP) standards are explained, as well as a brief assessment of existing products compliant with these standards. Finally, recommendations for achieving plant-wide integration using existing products are presented, and migration strategies for full OSI compliance are introduced. 5 refs., 16 figs. (JF)

INFORMATION TECHNOLOGY, INTERNET, AND MARKETING

OpenAIRE

Mihane Berisha-Namani

2013-01-01

Information technology developed very fast, and today's marketing activities are not possible without the help of information technology. Furthermore, it is difficult to think of a policy domain not affected by usage of information technology. Information technology is making possible and creating connections between businesses and organizations. The implications of information technology usage in marketing activities are profound too. Using information technology, companies possess the poten...

Harnessing the power of mobile technologies for collaborating, crowdsourcing, and creating

Science.gov (United States)

Crompton, H.

2015-12-01

Today's digital technologies can have a powerful influence on teaching and learning. M-learning and u-learning in particular are changing pedagogical practice. Sub categories are rapidly emerging, such as context-aware ubiquitous learning, that involve students learning subject content while immersed in authentic and relevant surroundings. Learning cultures are a nebulous blend of traditions, values, beliefs, and rituals built up over time. For a long time, education has long been conceived as classroom-based and predominantly sedentary (Merchant, 2012). Recent mobile technologies are disrupting this culture in favor of learning that is contextualized, personalized, on demand, and ubiquitous (Crompton, 2013). 21st century students are a different breed than past generations (Prensky, 2001). These students have grown up in a time that has not only altered their perceptions and practices but modified the wiring of the brain through neuroplasticity (Crompton, 2012). Students now cognitively receive information quickly through non-linear methods (Gross, 2003, Oblinger & Oblinger, 2005). They think differently. They also seem to be attached to mobile devices 24/7, although the content of the lesson does not match what they seem to be doing on the mobile devices. This presentation will showcase how to get your students to harness the power of mobile devices for educational purposes. For example, students in your classes will be using devices to collaborate on activities with Google Forms, crowdsourcing the best class questions in Slido, and screencasting thoughts and ideas to share with others with Educreations. These are examples of free apps or Web 2.0 tools that can be used on all the major mobile platforms. Crompton, H. (2013). Mobile learning: New approach, new theory. In Z. L. Berge & L. Y. Muilenburg (Eds.), Handbook of mobile learning (pp. 47-57). Prensky, M. (2001). Digital natives, digital immigrants. Mcb University Press, 9(5). Oblinger, D., & Oblinger, J

A Place to Call Home: Amphibian Use of Created and Restored Wetlands

Directory of Open Access Journals (Sweden)

Donald J. Brown

2012-01-01

Full Text Available Loss and degradation of wetland habitats are major contributing factors to the global decline of amphibians. Creation and restoration of wetlands could be a valuable tool for increasing local amphibian species richness and abundance. We synthesized the peer-reviewed literature addressing amphibian use of created and restored wetlands, focusing on aquatic habitat, upland habitat, and wetland connectivity and configuration. Amphibian species richness or abundance at created and restored wetlands was either similar to or greater than reference wetlands in 89% of studies. Use of created and restored wetlands by individual species was driven by aquatic and terrestrial habitat preferences, as well as ability to disperse from source wetlands. We conclude that creating and restoring wetlands can be valuable tools for amphibian conservation. However, the ecological needs and preferences of target species must be considered to maximize the potential for successful colonization and long-term persistence.

Emerging technologies to create inducible and genetically defined porcine cancer models

Directory of Open Access Journals (Sweden)

Lawrence B Schook

2016-02-01

Full Text Available There is an emerging need for new animal models that address unmet translational cancer research requirements. Transgenic porcine models provide an exceptional opportunity due to their genetic, anatomic and physiological similarities with humans. Due to recent advances in the sequencing of domestic animal genomes and the development of new organism cloning technologies, it is now very feasible to utilize pigs as a malleable species, with similar anatomic and physiological features with humans, in which to develop cancer models. In this review, we discuss genetic modification technologies successfully used to produce porcine biomedical models, in particular the Cre-loxP System as well as major advances and perspectives the CRISPR/Cas9 System. Recent advancements in porcine tumor modeling and genome editing will bring porcine models to the forefront of translational cancer research.

Emerging Technologies to Create Inducible and Genetically Defined Porcine Cancer Models.

Science.gov (United States)

Schook, Lawrence B; Rund, Laurie; Begnini, Karine R; Remião, Mariana H; Seixas, Fabiana K; Collares, Tiago

2016-01-01

There is an emerging need for new animal models that address unmet translational cancer research requirements. Transgenic porcine models provide an exceptional opportunity due to their genetic, anatomic, and physiological similarities with humans. Due to recent advances in the sequencing of domestic animal genomes and the development of new organism cloning technologies, it is now very feasible to utilize pigs as a malleable species, with similar anatomic and physiological features with humans, in which to develop cancer models. In this review, we discuss genetic modification technologies successfully used to produce porcine biomedical models, in particular the Cre-loxP System as well as major advances and perspectives the CRISPR/Cas9 System. Recent advancements in porcine tumor modeling and genome editing will bring porcine models to the forefront of translational cancer research.

Creating value through application of flotation science and technology

Energy Technology Data Exchange (ETDEWEB)

Clark, M.E.; Brake, I.; Huls, B.J.; Smith, B.E.; Yu, M. [BHP Billiton, Melbourne, Vic. (Australia)

2006-05-15

A brief outline of some of the pioneering events in the development of flotation technology, which originated in Broken Hill at the start of the 1900s, is presented. The development of the original Potter-Delprat process, the introduction of oils to generate froth flotation and the achievement of selective flotation processing are described, all focussed on solving challenges with the Broken Hill Pb-Ag-Zn ores. Some recent initiatives in flotation at BHP Billiton operations are also outlined, covering coal, copper, lead-silver-zinc and diamonds. Some views are offered on the characteristics of innovation in flotation and on possible trends into the future.

Physical Activity in an Underserved Population: Identifying Technology Preferences.

Science.gov (United States)

Medairos, Robert; Kang, Vicky; Aboubakare, Carissa; Kramer, Matthew; Dugan, Sheila Ann

2017-01-01

This study aims to identify patterns of use and preferences related to technology platforms that could support physical activity (PA) programs in an underserved population. A 29-item questionnaire was administered at 5 health and wellness sites targeting low income communities in Chicago. Frequency tables were generated for Internet, cell phone, and social media use and preferences. Chi-squared analysis was used to evaluate differences across age and income groups. A total of 291 individuals participated and were predominantly female (69.0%). Majority reported incomes less than $30,000 (72.9%) and identified as African American/Black/Caribbean (49.3%) or Mexican/Mexican American (34.3%). Most participants regularly used smartphones (63.2%) and the Internet (75.9%). Respondents frequently used Facebook (84.8%), and less commonly used Instagram (43.6%), and Twitter (20.0%). Free Internet-based exercise programs were the most preferred method to increase PA levels (31.6%), while some respondents (21.0%) thought none of the surveyed technology applications would help. Cell phone, Internet, and social media use is common among the surveyed underserved population. Technology preferences to increase PA levels varied, with a considerable number of respondents not preferring the surveyed technology platforms. Creating educational opportunities to increase awareness may maximize the effectiveness of technology-based PA interventions.

Physics and technology of superthin internal targets in storage rings

International Nuclear Information System (INIS)

Popov, S.G.

1989-01-01

The new generation of accelerators for coincidence electronuclear investigations is discussed. The luminosity and beam parameters are calculated for an electron storage ring with an internal target operating in the superthin regime. The advantages and disadvantages in comparison with conventional operation using an external beam and target are described. The intermediate results for 2 GeV electron scattering on polarized internal deuterium target are given (joint Novosibirsk-Argonne experiment). 32 refs.; 5 figs

Creating a Current Awareness Service Using Yahoo! Pipes and LibGuides

Directory of Open Access Journals (Sweden)

Elizabeth Kiscaden

2014-12-01

Full Text Available Migration from print to electronic journals brought an end to traditional current awareness services, which primarily utilized print routing. The emergence of Real Simple Syndication, or RSS feeds, and email alerting systems provided users with alternative services. To assist users with adopting these technologies, a service utilizing aggregate feeds to the library’s electronic journal content was created and made available through LibGuides. Libraries can resurrect current awareness services using current technologies to increase awareness and usage of library-provided electronic journal content. The current awareness service presented is an example of how libraries can build simple current awareness services utilizing freely accessible technologies.

Creating Long Term Income Streams for the 100 Year Starship Study Initiative

Science.gov (United States)

Sylvester, A. J.

Development and execution of long term research projects are very dependent on a consistent application of funding to maximize the potential for success. The business structure for the 100 Year Starship Study project should allow for multiple income streams to cover the expenses of the research objectives. The following examples illustrate the range of potential avenues: 1) affiliation with a charitable foundation for creating a donation program to fund a long term endowment for research, 2) application for grants to fund initial research projects and establish the core expertise of the research entity, 3) development of intellectual property which can then be licensed for additional revenue, 4) creation of spinout companies with equity positions retained by the lab for funding the endowment, and 5) funded research which is dual use for the technology goals of the interstellar flight research objectives. With the establishment of a diversified stream of funding options, then the endowment can be funded at a level to permit dedicated research on the interstellar flight topics. This paper will focus on the strategy of creating spinout companies to create income streams which would fund the endowment of the 100 Year Starship Study effort. This technique is widely used by universities seeking to commercially develop and market technologies developed by university researchers. An approach will be outlined for applying this technique to potentially marketable technologies generated as a part of the 100 Year Starship Study effort.

Technology Innovation

Science.gov (United States)

EPA produces innovative technologies and facilitates their creation in line with the Agency mission to create products such as the stormwater calculator, remote sensing, innovation clusters, and low-cost air sensors.

A Study of the Factors Associated with Successful Technology Transfer and their Applicability to Air Force Technology Transfers.

Science.gov (United States)

1995-09-01

transfer project. (D) 8a Organization has a technology transfer organization. (D,A) 10a Marketing and advertising of technologies targeted to relevant...Entrepreneurial (D) Developer: 10A: Marketing and advertising of technologies targeted to relevant industries. Most developers indicate that they marketed...regard to marketing and advertising . 10B: Technology maturation supported by internal units or by contracting out. Technology maturation is the

Technology transfer

International Nuclear Information System (INIS)

1998-01-01

On the base of technological opportunities and of the environmental target of the various sectors of energy system this paper intend to conjugate the opportunity/objective with economic and social development through technology transfer and information dissemination [it

STUDY OF HORIZONTAL SCREEN STRENGTH CREATED BY INJECTION TECHNOLOGY CEMENT BINDER BASED

Directory of Open Access Journals (Sweden)

BORISOV A. A.

2016-09-01

Full Text Available Annotation. Formulation of the problem. An important indicator in the planning of injection works is a particle size distribution of the soil and the very composition of injection. The ideal case is to comply with the injection optimum ratio between the size of particles in solution and injectable medium. This ratio corresponds to complete impregnation of the environment. Today in the field of building technologies known classical methods of grouting with the injection process [9]. This may be a cementation or silicification with different chemical compositions. Due to the fact that we have proposed an innovative technology of impervious curtain device, special attention should be paid to the performance and physical and mechanical properties of the resulting soil-injection. This is due to the fact that the proposed technology provides for lesser known technical solutions, the use of which should ultimately result in impervious screens with desired properties. Goal. The aim of this study is to investigate the properties of the resulting soil-concrete impervious screen. Such structures should have defined a number of physical and mechanical properties. In this paper, it was of interest to study the compressive strength of the resulting soil-concrete structure. Conclusion. As a result of experimentation and implementation of complex obtained experimentally-statistical models that describe the main soil-quality indicators. Based on these data is possible optimal selection of formulation and technological structure for sandy soils with different modules size of its particles.

Creating standards: Creating illusions?

DEFF Research Database (Denmark)

Linneberg, Mai Skjøtt

written standards may open up for the creation of illusions. These are created when written standards' content is not in accordance with the perception standard adopters and standard users have of the specific practice phenomenon's content. This general theoretical argument is exemplified by the specific...

Angular JS – The Newest Technology in Creating Web Applications

Directory of Open Access Journals (Sweden)

Radu BUCEA-MANEA-TONIS

2016-09-01

Full Text Available This article is the result of searching and selecting new technologies that help programmer in developing web applications. It also represents a pleading for using it, showing its advantages and disadvantages. Alongside the article there are features regarding binding elements, modules, filters and directives. It is a synthesis and a guide of good practice for innovative programmers. All technical issues presented are supported by a case study.

To create added value of smart home technology in small scale senior accommodations

NARCIS (Netherlands)

Dr. H.S.M. Kort; Hans Duits; Emelieke Huisman; Gerrit Jan Lanting

2013-01-01

Smart home technology has been introduced as a potential solution to support ageing in place, to enhance the quality of life of residents, or to decrease the workload of professionals. The ability of smart home technology is to monitor the activity of daily living and safety of residents. The aim of

The student`s training to creating computer games for preschool-age children

Directory of Open Access Journals (Sweden)

Мардарова И.К.

2016-09-01

Full Text Available The article deals with the special aspects of future kindergartner training to creating computer games for children of preschool age. The scratch-projects technology and recommendation for use at kindergarten pedagogical process are described in it.

Study and utilization of ion beams created in the Focus experiment

International Nuclear Information System (INIS)

Bernard, A.; Garconnet, J.P.; Jolas, A.; Le Breton, J.P.; Mascureau, J. de.

1982-06-01

Ion beams created in a plasma focus electrical discharge are evidenced and measured from interaction with CD 2 and DLi targets. Aluminum targets are also used with observation of the radiation temperature and material expansion velocity. Comparison between experimental measurements and numerical computations allows to determine energy deposition in the aluminum foil as well as beams values. With the 200 kJ Actime facility 2 to 3 MJ/g deposition is obtained in aluminum on approximately one square centimeter. A fast valve gas injection has been developed on another facility and preliminary results are given [fr

Pharmaceutical spray drying: solid-dose process technology platform for the 21st century.

Science.gov (United States)

Snyder, Herman E

2012-07-01

Requirement for precise control of solid-dosage particle properties created with a scalable process technology are continuing to expand in the pharmaceutical industry. Alternate methods of drug delivery, limited active drug substance solubility and the need to improve drug product stability under room-temperature conditions are some of the pharmaceutical applications that can benefit from spray-drying technology. Used widely for decades in other industries with production rates up to several tons per hour, pharmaceutical uses for spray drying are expanding beyond excipient production and solvent removal from crystalline material. Creation of active pharmaceutical-ingredient particles with combinations of unique target properties are now more common. This review of spray-drying technology fundamentals provides a brief perspective on the internal process 'mechanics', which combine with both the liquid and solid properties of a formulation to enable high-throughput, continuous manufacturing of precision powder properties.

ADVANTAGES OF GREEN TECHNOLOGY

OpenAIRE

Ghanshyam Das Soni

2017-01-01

Technology is application of knowledge to practical requirements. Green technologies encompass various aspects of technology which help us reduce the human impact on the environment and create ways of sustainable development. Social equitability, economic feasibility and sustainability are the key parameters for green technologies. Today the environment is racing towards the tipping point at which we would have done permanent irreversible damage to the planet earth. Our current actions are pu...

Creating the integral engineer : Combining development education, sustainability, entrepreneurship and technology at Delft University of Technology

NARCIS (Netherlands)

Zwarteveen, J.W.; Blom, E.M.; Vastbinder, B.; Brezet, J.C.

2010-01-01

A modern engineer is more than a technical specialist. Training an integral engineer requires education in non-technical skills, including social and ethical aspects. Therefore, Delft University of Technology (DUT) introduced sustainable development and entrepreneurship into its bachelor and master

LIFE Target Fabrication Research Plan Sept 2008

Energy Technology Data Exchange (ETDEWEB)

Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

2008-11-10

The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

Self-interested agents create, maintain, and modify group-functional culture.

Science.gov (United States)

Singh, Manvir; Glowacki, Luke; Wrangham, Richard W

2016-01-01

We agree that institutions and rules are crucial for explaining human sociality, but we question the claim of there not being "alternatives to CGS [that] can easily account for the institutionalized cooperation that characterizes human societies" (target article, sect. 7). Hypothesizing that self-interested individuals coercively and collaboratively create rules, we propose that agent-based hypotheses offer viable alternatives to cultural group selection (CGS).

Reflector Technology Development and System Design for Concentrating Solar Power Technologies

Energy Technology Data Exchange (ETDEWEB)

Adam Schaut

2011-12-30

Alcoa began this program in March of 2008 with the goal of developing and validating an advanced CSP trough design to lower the levelized cost of energy (LCOE) as compared to existing glass based, space-frame trough technology. In addition to showing a pathway to a significant LCOE reduction, Alcoa also desired to create US jobs to support the emerging CSP industry. Alcoa's objective during Phase I: Concept Feasibility was to provide the DOE with a design approach that demonstrates significant overall system cost savings without sacrificing performance. Phase I consisted of two major tasks; reflector surface development and system concept development. Two specific reflective surface technologies were investigated, silver metallized lamination, and thin film deposition both applied on an aluminum substrate. Alcoa prepared samples; performed test validation internally; and provided samples to the NREL for full-spectrum reflectivity measurements. The final objective was to report reflectivity at t = 0 and the latest durability results as of the completion of Phase 1. The target criteria for reflectance and durability were as follows: (1) initial (t = 0), hemispherical reflectance >93%, (2) initial spectral reflectance >90% for 25-mrad reading and >87% for 7-mrad reading, and (3) predicted 20 year durability of less than 5% optical performance drop. While the results of the reflective development activities were promising, Alcoa was unable to down-select on a reflective technology that met the target criteria. Given the progress and potential of both silver film and thin film technologies, Alcoa continued reflector surface development activities in Phase II. The Phase I concept development activities began with acquiring baseline CSP system information from both CSP Services and the DOE. This information was used as the basis to develop conceptual designs through ideation sessions. The concepts were evaluated based on estimated cost and high-level structural

Clearing the Fog of Anticancer Patents from 1993–2013: Through an In-Depth Technology Landscape & Target Analysis from Pioneer Research Institutes and Universities Worldwide

Science.gov (United States)

Dara, Ajay; Sangamwar, Abhay T.

2014-01-01

Background In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR): India’s largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. Methodology/Principal Findings The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. Conclusions/Significance The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade anticancer scenario

Combining technologies to create bioactive hybrid scaffolds for bone tissue engineering

NARCIS (Netherlands)

Nandakumar, A.; Barradas, A.M.C.; de Boer, Jan; Moroni, Lorenzo; van Blitterswijk, Clemens; Habibovic, Pamela

2013-01-01

Combining technologies to engineer scaffolds that can offer physical and chemical cues to cells is an attractive approach in tissue engineering and regenerative medicine. In this study, we have fabricated polymer-ceramic hybrid scaffolds for bone regeneration by combining rapid prototyping (RP),

Education, Technology and Health Literacy

DEFF Research Database (Denmark)

Lindgren, Kurt; Sølling, Ina Koldkjær; Carøe, Per

The purpose of this study is to develop an interdisciplinary learning environment between education in technology, business, and nursing. This collaboration contributes to the creation of a natural interest and motivation for welfare technology. The aim of establishing an interaction between the 3...... as a theoretical and practical learning center. The mission of the Student Academy is to support and facilitate education in order to maintain and upgrade knowledge and skills in information technology and information management in relation to e-health and Health Literacy. The Student Academy inspires students...... areas of expertise is to create an understanding for each other's skills and cultural differences. Futhermore enabling future talents to gain knowledge and skills to improve Health Literacy among senior citizens. Based on a holistic view on welfare technology a Student Academy was created...

Education, Technology and Health Literacy

DEFF Research Database (Denmark)

Lindgren, Kurt; Sølling, Ina Koldkjær; Carøe, Per

2016-01-01

Abstract The purpose of this study is to develop an interdisciplinary learning environment between education in technology, business, and nursing. This collaboration contributes to the creation of a natural interest and motivation for welfare technology. The aim of establishing an interaction...... as a theoretical and practical learning center. The mission of the Student Academy is to support and facilitate education in order to maintain and upgrade knowledge and skills in information technology and information management in relation to e-health and Health Literacy. The Student Academy inspires students...... between the 3 areas of expertise is to create an understanding for each other's skills and cultural differences. Futhermore enabling future talents to gain knowledge and skills to improve Health Literacy among senior citizens. Based on a holistic view on welfare technology a Student Academy was created...

Assessing consumer benefits of selected gas appliance technology center tasks. Topical report, April-December 1992

International Nuclear Information System (INIS)

Smith, T.R.; Bournakis, A.D.; Worek, W.M.; Kalensky, D.C.; Dombrowski, L.P.

1992-12-01

The Gas Appliance Technology Center (GATC) was created in 1983 to assist the gas industry in bringing about a new generation of reasonably priced, advanced gas appliances. The objective of the report is to evaluate consumer benefits of sixteen selected GATC tasks for the time period between 1983 and 1990. Tasks were selected for review based upon their degree of industry impact and how well they represented activities in the four targeted research areas of Space Conditioning, Commercial Appliances, Residential Appliances, and Codes and Standards

FY05 Targeted Technology Transfer to US Independents

Energy Technology Data Exchange (ETDEWEB)

Donald F. Duttlinger; E. Lance Cole

2005-11-01

Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers in 1994 as a national not-for-profit organization to address the increasingly urgent need to improve the technology-transfer process in the U.S. upstream petroleum industry. PTTC's technology-transfer programs enhance U.S. national security. PTTC administers the only nation-wide, comprehensive program dedicated to maximizing America's supplies of domestic oil and gas. PTTC conducts grassroots programs through 10 Regional Lead Organizations (RLOs) and two satellite offices, leveraging their preexisting connections with industry. This organizational structure helps bring researchers and academia to the table. Nationally and regionally, volunteers within a National Board and Regional Producer Advisory Groups guide efforts. The National Board meets three times per year, an important function being approving the annual plans and budgets developed by the regions and Headquarters (HQ). Between Board meetings, an active Management and Budget Committee guide HQ activity. PTTC itself undergoes a thorough financial audit each year. The PTTC's HQ staff plans and manages all aspects of the PTTC program, conducts nation-wide technology-transfer activities, and implements a comprehensive communications program. Networking, involvement in technical activities, and an active exhibit schedule are increasing PTTC's sphere of influence with both producers and the oilfield service sector. Circulation for ''PTTC Network News'', the quarterly newsletter, has risen to nearly 17,500. About 7,500 people receive an email Technology Alert on an approximate three-week frequency. Case studies in the ''Petroleum Technology Digest in World Oil'' appear monthly, as do ''Tech Connections'' columns in ''The American Oil and Gas Reporter''. As part of its oversight responsibility for the regions

THE SOUND OF CINEMA: TECHNOLOGY AND CREATIVITY

Directory of Open Access Journals (Sweden)

Poznin Vitaly F.

2017-12-01

Full Text Available Technology is a means of creating any product. However, in the onscreen art, it is one of the elements creating the art space of film. Considering the main stages of the development of cinematography, this article explores the influence of technology of sound recording on the creating a special artistic and physical space of film (the beginning of the use a sound in movies; the mastering the artistic means of an audiovisual work; the expansion of the spatial characteristics for the screen sound; and the sound in a modern cinema. Today, thanks to new technologies, the sound in a cinema forms a specific quasirealistic landscape, greatly enhancing the impact on the viewer of the virtual screen images.

76 FR 37344 - Technology Evaluation Process

Science.gov (United States)

2011-06-27

...-NOA-0039] Technology Evaluation Process AGENCY: Office of Energy Efficiency and Renewable Energy... seeks comments and information related to a commercial buildings technology evaluation process. DOE is seeking to create a process for evaluating emerging and underutilized energy efficient technologies for...

Targets for high power neutral beams

International Nuclear Information System (INIS)

Kim, J.

1980-01-01

Stopping high-power, long-pulse beams is fast becoming an engineering challenge, particularly in neutral beam injectors for heating magnetically confined plasmas. A brief review of neutral beam target technology is presented along with heat transfer calculations for some selected target designs

The Next Technology Revolution - Nano Electronic Technology

Science.gov (United States)

Turlik, Iwona

2004-03-01

Nanotechnology is a revolutionary engine that will engender enormous changes in a vast majority of today's industries and markets, while potentially creating whole new industries. The impact of nanotechnology is particularly significant in the electronics industry, which is constantly driven by the need for higher performance, increased functionality, smaller size and lower cost. Nanotechnology can influence many of the hundreds of components that are typically assembled to manufacture modern electronic devices. Motorola manufactures electronics for a wide range of industries and communication products. In this presentation, the typical components of a cellular phone are outlined and technology requirements for future products, the customer benefits, and the potential impact of nanotechnology on many of the components are discussed. Technology needs include reliable materials supply, processes for high volume production, experimental and simulation tools, etc. For example, even routine procedures such as failure characterization may require the development of new tools for investigating nano-scale phenomena. Business needs include the development of an effective, high volume supply chain for nano-materials and devices, disruptive product platforms, and visible performance impact on the end consumer. An equally significant long-term industry need is the availability of science and engineering graduates with a multidisciplinary focus and a deep understanding of the fundamentals of nano-technology, that can harness the technology to create revolutionary products.

Study on laser beam welding technology for nuclear power plants

International Nuclear Information System (INIS)

Chida, Itaru; Shiihara, Katsunori; Fukuda, Takeshi; Kono, Wataru; Obata, Minoru; Morishima, Yasuo

2012-01-01

Laser beam welding is one of the jointing processes by irradiating laser beam on the material surface locally and widely used at various industrial fields. Toshiba has developed various laser-based maintenance and repair technologies and already applied them to several existing nuclear power plants. Laser cladding is a technique to weld the corrosion resistant metal onto a substrate surface by feeding filler wire to improve the corrosion resistance. Temper-bead welding is the heat input process to provide the desired microstructure properties of welded low alloy steels without post weld heat treatment, by inducing proper heat cycle during laser welding. Both laser welding technologies would be performed underwater by blowing the shielding gas for creating the local dry area. In this report, some evaluation results of material characteristics by temper-bead welding to target at Reactor Coolant System nozzle of PWR are presented. (author)

Promoting renewable energy technologies

DEFF Research Database (Denmark)

Olsen, O.J.; Skytte, K.

2004-01-01

% of its annual electricity production. In this paper, we present and discuss the Danish experience as a case of promoting renewable energy technologies. The development path of the two technologies has been very different. Wind power is considered an outright success with fast deployment to decreasing...... technology and its particular context, it is possible to formulate some general principles that can help to create an effective and efficient policy for promoting new renewable energy technologies....

NASA Astrophysics Technology Needs

Science.gov (United States)

Stahl, H. Philip

2012-01-01

July 2010, NASA Office of Chief Technologist (OCT) initiated an activity to create and maintain a NASA integrated roadmap for 15 key technology areas which recommend an overall technology investment strategy and prioritize NASA?s technology programs to meet NASA?s strategic goals. Science Instruments, Observatories and Sensor Systems(SIOSS) roadmap addresses technology needs to achieve NASA?s highest priority objectives -- not only for the Science Mission Directorate (SMD), but for all of NASA.

Experimental Comparison of the Tribological Properties of Selected Surfaces Created by Thermal Spraying Technology

Directory of Open Access Journals (Sweden)

František Tóth

2016-01-01

Full Text Available The scientific article titled “Experimental comparison of the tribological properties of selected surfaces created by thermal spraying technology” deals with the surface condition of selected pairs working within the mixed friction before and after experimental tests. Based on the chosen methodology, the experimental tests were performed on the Tribotestor M’06 testing machine. The ecological oil MOGUL HEES 46 (manufactured by Paramo was used as a lubricant. The tests were performed on selected material pairs. The first friction element was a shaft of steel 14 220. The second friction element was a steel plate of steel 11 373 with a friction surface created by two materials, i.e. CuSn10 and NP 40. The results are statistically elaborated and illustrated in figures and tables.

The interface between forensic science and technology: how technology could cause a paradigm shift in the role of forensic institutes in the criminal justice system.

Science.gov (United States)

Kloosterman, Ate; Mapes, Anna; Geradts, Zeno; van Eijk, Erwin; Koper, Carola; van den Berg, Jorrit; Verheij, Saskia; van der Steen, Marcel; van Asten, Arian

2015-08-05

In this paper, the importance of modern technology in forensic investigations is discussed. Recent technological developments are creating new possibilities to perform robust scientific measurements and studies outside the controlled laboratory environment. The benefits of real-time, on-site forensic investigations are manifold and such technology has the potential to strongly increase the speed and efficacy of the criminal justice system. However, such benefits are only realized when quality can be guaranteed at all times and findings can be used as forensic evidence in court. At the Netherlands Forensic Institute, innovation efforts are currently undertaken to develop integrated forensic platform solutions that allow for the forensic investigation of human biological traces, the chemical identification of illicit drugs and the study of large amounts of digital evidence. These platforms enable field investigations, yield robust and validated evidence and allow for forensic intelligence and targeted use of expert capacity at the forensic institutes. This technological revolution in forensic science could ultimately lead to a paradigm shift in which a new role of the forensic expert emerges as developer and custodian of integrated forensic platforms. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

The interface between forensic science and technology: how technology could cause a paradigm shift in the role of forensic institutes in the criminal justice system

Science.gov (United States)

Kloosterman, Ate; Mapes, Anna; Geradts, Zeno; van Eijk, Erwin; Koper, Carola; van den Berg, Jorrit; Verheij, Saskia; van der Steen, Marcel; van Asten, Arian

2015-01-01

In this paper, the importance of modern technology in forensic investigations is discussed. Recent technological developments are creating new possibilities to perform robust scientific measurements and studies outside the controlled laboratory environment. The benefits of real-time, on-site forensic investigations are manifold and such technology has the potential to strongly increase the speed and efficacy of the criminal justice system. However, such benefits are only realized when quality can be guaranteed at all times and findings can be used as forensic evidence in court. At the Netherlands Forensic Institute, innovation efforts are currently undertaken to develop integrated forensic platform solutions that allow for the forensic investigation of human biological traces, the chemical identification of illicit drugs and the study of large amounts of digital evidence. These platforms enable field investigations, yield robust and validated evidence and allow for forensic intelligence and targeted use of expert capacity at the forensic institutes. This technological revolution in forensic science could ultimately lead to a paradigm shift in which a new role of the forensic expert emerges as developer and custodian of integrated forensic platforms. PMID:26101289

Using automatic item generation to create multiple-choice test items.

Science.gov (United States)

Gierl, Mark J; Lai, Hollis; Turner, Simon R

2012-08-01

Many tests of medical knowledge, from the undergraduate level to the level of certification and licensure, contain multiple-choice items. Although these are efficient in measuring examinees' knowledge and skills across diverse content areas, multiple-choice items are time-consuming and expensive to create. Changes in student assessment brought about by new forms of computer-based testing have created the demand for large numbers of multiple-choice items. Our current approaches to item development cannot meet this demand. We present a methodology for developing multiple-choice items based on automatic item generation (AIG) concepts and procedures. We describe a three-stage approach to AIG and we illustrate this approach by generating multiple-choice items for a medical licensure test in the content area of surgery. To generate multiple-choice items, our method requires a three-stage process. Firstly, a cognitive model is created by content specialists. Secondly, item models are developed using the content from the cognitive model. Thirdly, items are generated from the item models using computer software. Using this methodology, we generated 1248 multiple-choice items from one item model. Automatic item generation is a process that involves using models to generate items using computer technology. With our method, content specialists identify and structure the content for the test items, and computer technology systematically combines the content to generate new test items. By combining these outcomes, items can be generated automatically. © Blackwell Publishing Ltd 2012.

Prospects of technology adoption in small pump schemes in the River Nile State, Sudan

International Nuclear Information System (INIS)

Ahmed, A. T.; Hashim, A. A.

2010-01-01

Linear programming was used to simulate the farming systems of small pump schemes in Shendi Area, River Nile State, Sudan, to assess the prospect for technology use in cool-season food legumes and wheat. Different production activities, with respect to target crops, were identified to reflect different technology levels. The model constraints were the pump capacity, the scheme size and family labour. Alternative versions of the model were developed to examine possible production options that exist and to examine the effects of alternative resource levels and policy options, which are likely to affects adoption. The model results revealed that while farmers traditional practices were not economically feasible options, tendency is for adoption of medium rather than the recommended high technology levels. This reflects actual farmers behaviour, particularly for irrigation water, and indicates that water is the main resource constraint. The results also showed that the technology is not well supported by the traditional institutions of production relation, which create conflicting perception between resource owner to wards technology use.(Author)

Targeting Non-Coding RNAs in Plants with the CRISPR-Cas Technology is a Challenge yet Worth Accepting.

Science.gov (United States)

Basak, Jolly; Nithin, Chandran

2015-01-01

Non-coding RNAs (ncRNAs) have emerged as versatile master regulator of biological functions in recent years. MicroRNAs (miRNAs) are small endogenous ncRNAs of 18-24 nucleotides in length that originates from long self-complementary precursors. Besides their direct involvement in developmental processes, plant miRNAs play key roles in gene regulatory networks and varied biological processes. Alternatively, long ncRNAs (lncRNAs) are a large and diverse class of transcribed ncRNAs whose length exceed that of 200 nucleotides. Plant lncRNAs are transcribed by different RNA polymerases, showing diverse structural features. Plant lncRNAs also are important regulators of gene expression in diverse biological processes. There has been a breakthrough in the technology of genome editing, the CRISPR-Cas9 (clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9) technology, in the last decade. CRISPR loci are transcribed into ncRNA and eventually form a functional complex with Cas9 and further guide the complex to cleave complementary invading DNA. The CRISPR-Cas technology has been successfully applied in model plants such as Arabidopsis and tobacco and important crops like wheat, maize, and rice. However, all these studies are focused on protein coding genes. Information about targeting non-coding genes is scarce. Hitherto, the CRISPR-Cas technology has been exclusively used in vertebrate systems to engineer miRNA/lncRNAs, but it is still relatively unexplored in plants. While briefing miRNAs, lncRNAs and applications of the CRISPR-Cas technology in human and animals, this review essentially elaborates several strategies to overcome the challenges of applying the CRISPR-Cas technology in editing ncRNAs in plants and the future perspective of this field.

Targeting non-coding RNAs in Plants with the CRISPR-Cas technology is a challenge yet worth accepting

Directory of Open Access Journals (Sweden)

Jolly eBasak

2015-11-01

Full Text Available Non-coding RNAs (ncRNAs have emerged as versatile master regulator of biological functions in recent years. MicroRNAs (miRNAs are small endogenous ncRNAs of 18-24 nucleotides in length that originates from long self-complementary precursors. Besides their direct involvement in developmental processes, plant miRNAs play key roles in gene regulatory networks and varied biological processes. Alternatively, long ncRNAs (lncRNAs are a large and diverse class of transcribed ncRNAs whose length exceed that of 200 nucleotides. Plant lncRNAs are transcribed by different RNA polymerases, showing diverse structural features. Plant lncRNAs also are important regulators of gene expression in diverse biological processes. There has been a breakthrough in the technology of genome editing, the CRISPR-Cas9 (clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 technology, in the last decade. CRISPR loci are transcribed into ncRNA and eventually form a functional complex with Cas9 and further guide the complex to cleave complementary invading DNA. The CRISPR-Cas technology has been successfully applied in model plants such as Arabidopsis and tobacco and important crops like wheat, maize and rice. However, all these studies are focused on protein coding genes. Information about targeting non-coding genes is scarce. Hitherto, the CRISPR-Cas technology has been exclusively used in vertebrate systems to engineer miRNA/lncRNAs, but it is still relatively unexplored in plants. While briefing miRNAs, lncRNAs and applications of the CRISPR-Cas technology in human and animals, this review essentially elaborates several strategies to overcome the challenges of applying the CRISPR-Cas technology in editing ncRNAs in plants and the future perspective of this field.

Compete or Leapfrog: Creating Blue Ocean through Entrepreneurial Orientation

OpenAIRE

Arslan Ayub; Muhammad Salman Aslam; Hanan Iftekhar; Adeel Razzaq; Sabiha Hafeez

2013-01-01

The study analyzes the role of entrepreneurial orientation with mediating effect of knowledge creation process to creating Blue Ocean in corporate sector in Pakistan There is an increasing competition among companies due to globalization and technological advancements. Thus, it requires a study to measure the multifaceted influence of entrepreneurial orientation on knowledge creation process and Blue Ocean besides the actual paradigm of this terminology. This concept has been well discussed i...

CREATING NEW MARKETING STRATEGY FOR CASE COMPANY ADVENTURE NET

OpenAIRE

Koleva, Hristina

2017-01-01

The purpose of this thesis was to create new, more successful marketing strategy for case company Adventure Net through analyzing the current marketing strategy and market environment of the company. The tools included in the theoretical part were used to analyze the market environment and marketing strategy. The analyzing tools included were PESTEL (Political, Economic, Social, Technological, Ecologic, Legal) analysis, SWOT (Strengths, Weaknesses, Threats, Opportunities) analysis and com...

Fabrication technology for a series of cylindrical thin-wall cavity targets

CERN Document Server

Zheng Yong; Sun Zu Oke; Wang Ming Da; Zhou La; Zhou Zhi Yun

2002-01-01

Cylindrical thin-wall cavity targets have been fabricated to study the behavior of superthermal electrons and their effects on inertial confinement fusion (ICF). Self-supporting cavity targets having adjustable, uniform wall thickness, and low surface roughness were required. This required production of high-quality mandrels, coating them by sputtering or electroplating, developing techniques for measurement of wall thickness and other cavity parameters, improving the uniformity of rotation of the mandrels, and preventing damage to the targets during removal from the mandrels. Details of the fabrication process are presented. Experimental results from the use of these targets are presented. These results, in good agreement with simulations, indicate that the use of thin-wall cavity targets is an effective method for studying superthermal electrons in ICF.

76 FR 30696 - Technology Evaluation Process

Science.gov (United States)

2011-05-26

...-NOA-0039] Technology Evaluation Process AGENCY: Office of Energy Efficiency and Renewable Energy... (DOE) seeks comments and information related to a commercial buildings technology evaluation process... evaluation efforts. The goal of creating this standard process is to evaluate energy-saving technologies in a...

Inertial confinement fusion target component fabrication and technology development support. Annual report 10/1/98 through 9/30/99

International Nuclear Information System (INIS)

Gibson, Jane

1999-01-01

General Atomics (GA) has served as the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor for the U.S. Department of Energy since December 30, 1990. This report documents the technical activities of the period October 1, 1998 through September 30, 1999. During this period, GA and our partner Schafer Corporation were assigned 17 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory (SNL). We fabricated and delivered over 1790 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNL. We produced more than 1380 glass and plastic target capsules over a wide range of sizes and designs (plus over 300 near target-quality capsules) for LLNL, LANL, SNL, and University of Rochester/Laboratory for Laser Energetic (UR/LLE). We also delivered various target foils and films for Naval Research Lab (NRL) and UWLLE in FY99. We fabricated a device to polish NIF-sized beryllium shells and prepared a laboratory for the safe operation of beryllium polishing activities. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY99, the GA/Schafer portion of the GA/Schafer-UR/LLE-LANL team effort for design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA was completed. All components of the OCTS were procured, fabricated, assembled, tested, and shipped to UR/LLE. Only minor documentation tasks remain to be done in FY00. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D2 or deuterium

Technology certification and technology acceptance: Promoting interstate cooperation and market development for innovative technologies

International Nuclear Information System (INIS)

Brockbank, B.R.

1995-03-01

In the past two years, public and private efforts to promote development and deployment of innovative environmental technologies have shifted from the analysis of barriers to the implementation of a variety of initiatives aimed at surmounting those barriers. Particular attention has been directed at (1) streamlining fragmented technology acceptance processes within and among the states, and (2) alleviating disincentives, created by inadequate or unverified technology cost and performance data, for users and regulators to choose innovative technologies. Market fragmentation currently imposes significant cost burdens on technology developers and inhibits the investment of private capital in environmental technology companies. Among the responses to these problems are state and federal technology certification/validation programs, efforts to standardize cost/performance data reporting, and initiatives aimed at promoting interstate cooperation in technology testing and evaluation. This paper reviews the current status of these initiatives, identifies critical challenges to their success, and recommends strategies for addressing those challenges

Creating an Intentional Web Presence: Strategies for Every Educational Technology Professional

Science.gov (United States)

Lowenthal, Patrick R.; Dunlap, Joanna C.; Stitson, Patricia

2016-01-01

Educators are pushing for students, specifically graduates, to be digitally literate in order to successfully read, write, contribute, and ultimately compete in the global market place. Educational technology professionals, as a unique type of learning professional, need to be not only digitally literate--leading and assisting teachers and…

Creating a soil-like profile for plant growth using tailings sand and fine tails

International Nuclear Information System (INIS)

Li, X.; Fung, M. P. Y.

1996-01-01

Development of a technology to create stable aggregates with a soil-like profile capable of supporting a stable plant community, was discussed as the major challenge and primary task in restoring oil sands processing wastes, and in re-creating a self-sustaining ecosystem. A procedure for creating a soil-like profile using oil sands mining wastes, was described. Clay and water content were critical factors in the aggregation procedure. A study to evaluate the physical, chemical and biological properties of these soils and their suitability as a plant growth medium is currently underway. 6 refs., 3 figs

Modification of K-line emission profiles in laser-created solid-density plasmas

International Nuclear Information System (INIS)

Sengebusch, A.; Reinholz, H.; Roepke, G.

2010-01-01

Complete text of publication follows. X-ray emissions in the keV energy range have shown to be suitable radiation to investigate the properties of laser-created solid-density plasmas. We use the modifications of inner shell transitions due to the environment to characterize these plasmas. A theoretical treatment of spectral line profiles based on a self-consistent ion sphere model is applied on moderately ionized mid-Z materials, such as titanium, silicon and chlorine. We observe large contributions of satellite transitions due to M-shell ionization and excitation. To determine the composition a mixture of various excited and ionized ionic states embedded in a plasma has to be considered. Plasma polarization effects that cause shifts of the emission and ionization energies are taken into account. K-line profiles are calculated for bulk temperatures up to 100 eV and free electron densities up to 10 24 cm -3 in order to analyze recent measurements with respect to the plasma parameters of electron heated target regions. Moreover, in high-intensity laser-matter interactions, inevitable prepulses are likely to create preplasma and shocks within the target before the main pulse arrives. We investigate the influence of density gradients due to prepulses on the spectral profiles. Further, radial bulk temperature distributions as well the composition of the created warm dense matter are inferred.

Trapped between two tails: trading off scientific uncertainties via climate targets

International Nuclear Information System (INIS)

Lemoine, Derek; McJeon, Haewon C

2013-01-01

Climate change policies must trade off uncertainties about future warming, about the social and ecological impacts of warming, and about the cost of reducing greenhouse gas emissions. We show that laxer carbon targets produce broader distributions for climate damages, skewed towards severe outcomes. However, if potential low-carbon technologies fill overlapping niches, then more stringent carbon targets produce broader distributions for the cost of reducing emissions, skewed towards high-cost outcomes. We use the technology-rich GCAM integrated assessment model to assess the robustness of 450 and 500 ppm carbon targets to each uncertain factor. The 500 ppm target provides net benefits across a broad range of futures. The 450 ppm target provides net benefits only when impacts are greater than conventionally assumed, when multiple technological breakthroughs lower the cost of abatement, or when evaluated with a low discount rate. Policy evaluations are more sensitive to uncertainty about abatement technology and impacts than to uncertainty about warming. (letter)

Trapped between two tails: trading off scientific uncertainties via climate targets

Science.gov (United States)

Lemoine, Derek; McJeon, Haewon C.

2013-09-01

Climate change policies must trade off uncertainties about future warming, about the social and ecological impacts of warming, and about the cost of reducing greenhouse gas emissions. We show that laxer carbon targets produce broader distributions for climate damages, skewed towards severe outcomes. However, if potential low-carbon technologies fill overlapping niches, then more stringent carbon targets produce broader distributions for the cost of reducing emissions, skewed towards high-cost outcomes. We use the technology-rich GCAM integrated assessment model to assess the robustness of 450 and 500 ppm carbon targets to each uncertain factor. The 500 ppm target provides net benefits across a broad range of futures. The 450 ppm target provides net benefits only when impacts are greater than conventionally assumed, when multiple technological breakthroughs lower the cost of abatement, or when evaluated with a low discount rate. Policy evaluations are more sensitive to uncertainty about abatement technology and impacts than to uncertainty about warming.

Technological advances and proteomic applications in drug discovery and target deconvolution: identification of the pleiotropic effects of statins.

Science.gov (United States)

Banfi, Cristina; Baetta, Roberta; Gianazza, Erica; Tremoli, Elena

2017-06-01

Proteomic-based techniques provide a powerful tool for identifying the full spectrum of protein targets of a drug, elucidating its mechanism(s) of action, and identifying biomarkers of its efficacy and safety. Herein, we outline the technological advancements in the field, and illustrate the contribution of proteomics to the definition of the pharmacological profile of statins, which represent the cornerstone of the prevention and treatment of cardiovascular diseases (CVDs). Statins act by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, thus reducing cholesterol biosynthesis and consequently enhancing the clearance of low-density lipoproteins from the blood; however, HMG-CoA reductase inhibition can result in a multitude of additional effects beyond lipid lowering, known as 'pleiotropic effects'. The case of statins highlights the unique contribution of proteomics to the target profiling of a drug molecule. Copyright © 2017 Elsevier Ltd. All rights reserved.

Distance Education at Silesian University of Technology

Directory of Open Access Journals (Sweden)

Piotr Klosowski

2008-12-01

Full Text Available This paper presents Distance Learning Platform used by Silesian University of Technology. Distance Learning Platform is based on modular object-oriented dynamic learning environment, represents LMS (Learning Management Systems technology, a software package designed to help educators create quality online courses. Currently on Distance Learning Platform at Silesian University of Technology are available over 520 online courses created for students of twelve University's faculties. Number of Distance Learning Platform users exceeds 12000. Distance Learning Platform works as typically asynchronous e-learning service, but in the future more synchronous e-learning services will be added. Distance Learning Platform has great potential to create a successful elearning experience by providing a plethora of excellent tools that can be used to enhance conventional classroom instruction, in hybrid courses, or any distance learning arrangements.

Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1993--September 30, 1994

Energy Technology Data Exchange (ETDEWEB)

Hoppe, M. [ed.

1995-04-01

On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. During the period, GA was assigned 17 tasks in support of the Inertial Confinement Fusion program and its laboratories. This year they achieved full production capabilities for the micromachining, dimensional characterization and gold plating of hohlraums. They fabricated and delivered 726 gold-plated mandrels of 27 different types to LLNL and 48 gold-plated mandrels of two different types to LANL. They achieved full production capabilities in composite capsule production ad delivered in excess of 240 composite capsules. They continuously work to improve performance and capabilities. They were also directed to dismantle, remove, and disposition all equipment at the previous contractor (KMSF) that had radioactive contamination levels low enough that they could be exposed to the general public without radiological constraints. GA was also directed to receive and store the tritium fill equipment. They assisted LANL in the development of techniques for characterization of opaque targets. They developed deuterated and UV-opaque polymers for use by the University of Rochester`s Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process. The ICF program is anticipating experiments at NIF and the Omega Upgrade. Both facilities will require capsules containing layered D{sub 2} or D-T fuel. They continued engineering and assembly of equipment for a cryogenic target handling system for UR/LLE that will fill, transport, layer, and characterize targets filled with cryogenic deuterium or deuterium-tritium fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments.

Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1993--September 30, 1994

International Nuclear Information System (INIS)

Hoppe, M.

1995-04-01

On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. During the period, GA was assigned 17 tasks in support of the Inertial Confinement Fusion program and its laboratories. This year they achieved full production capabilities for the micromachining, dimensional characterization and gold plating of hohlraums. They fabricated and delivered 726 gold-plated mandrels of 27 different types to LLNL and 48 gold-plated mandrels of two different types to LANL. They achieved full production capabilities in composite capsule production ad delivered in excess of 240 composite capsules. They continuously work to improve performance and capabilities. They were also directed to dismantle, remove, and disposition all equipment at the previous contractor (KMSF) that had radioactive contamination levels low enough that they could be exposed to the general public without radiological constraints. GA was also directed to receive and store the tritium fill equipment. They assisted LANL in the development of techniques for characterization of opaque targets. They developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process. The ICF program is anticipating experiments at NIF and the Omega Upgrade. Both facilities will require capsules containing layered D 2 or D-T fuel. They continued engineering and assembly of equipment for a cryogenic target handling system for UR/LLE that will fill, transport, layer, and characterize targets filled with cryogenic deuterium or deuterium-tritium fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments

Technology Innovations to Improve Biomass Cookstoves to Meet Tier 4 Standards

Energy Technology Data Exchange (ETDEWEB)

Still, Dean K [Aprovecho Research Center, Cottage Grove, OR (United States); Hatfield, Micheal S [Aprovecho Research Center, Cottage Grove, OR (United States)

2015-12-15

Technology Innovations to Improve Biomass Cookstoves to Meet Tier 4 Standards. Protecting public health has become a major motivation for investigating how improved cook stoves might function as a viable intervention. Currently, the great majority of cookstoves for sale in the developing world were not designed for this purpose but instead success was based on criteria such as reduced fuel use, affordability, and ease of use. With DOE funding Aprovecho Research Center spent three years creating stoves using an iterative development and modeling approach resulting in four stoves that in lab tests met the World Health Organization (2014) intermediate rate vented targets for PM2.5 and for CO.

45 CFR 170.210 - Standards for health information technology to protect electronic health information created...

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Standards for health information technology to... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION... FOR HEALTH INFORMATION TECHNOLOGY Standards and Implementation Specifications for Health Information...

Implement the medical group revenue function. Create competitive advantage.

Science.gov (United States)

Colucci, C

1998-01-01

This article shows medical groups how they can employ new financial management and information technology techniques to safeguard their revenue and income streams. These managerial techniques stem from the application of the medical group revenue function, which is defined herein. This article also describes how the medical group revenue function can be used to create value by employing a database and a decision support system. Finally, the article describes how the decision support system can be used to create competitive advantage. Through the wise use of internally generated information, medical groups can negotiate better contract terms, improve their operations, cut their costs, embark on capital investment programs and improve market share. As medical groups gain market power by improving in these areas, they will be more attractive to potential strategic allies, payers and investment bankers.

Early Mandarin Literacy in a Class-created Reading Library

Directory of Open Access Journals (Sweden)

Reed Riggs

2017-06-01

Full Text Available This article explores methods for creating an extensive reading (ER library during the first weeks of language instruction, illustrated here in a college Mandarin course. Data include student-created texts, video transcripts of students reading in groups, field notes, and a student perceptions survey. Taken together the data provide a snapshot of how students in a beginning-level university Mandarin course can utilize Internet resources to create and use a personalized ER library. ER has been shown in previous research to enrich known words (Waring & Takaki, 2003, and provide opportunities for early literacy in languages that use nonalphabetic scripts like Japanese (Hitosugi & Day, 2004. Mandarin texts feature Chinese characters, which exhibit a low reliability in sound-meaning-visual associations, effectively blocking learners from sounding out unfamiliar words and clearly identifying meaning (Everson et al., 2016. The data here show how learners were able to connect prior knowledge from their own culture to new communicative situations in the form of printed comic books to read in class in small groups. Learners were found to connect understandings between their own culture and the target culture, focusing particularly on cultural similarities.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, GROUNDWATER SAMPLING TECHNOLOGIES, GEOPROBE INC., PNEUMATIC BLADDER PUMP GW 1400 SERIES

Science.gov (United States)

The U.S. Environmental Protection Agency (EPA) design efficient processes for conducting has created the Environmental Technology perfofl1lance tests of innovative technologies. Verification Program (E TV) to facilitate the deployment of innovative or improved environmental techn...

Ligand-targeted theranostic nanomedicines against cancer.

Science.gov (United States)

Yao, Virginia J; D'Angelo, Sara; Butler, Kimberly S; Theron, Christophe; Smith, Tracey L; Marchiò, Serena; Gelovani, Juri G; Sidman, Richard L; Dobroff, Andrey S; Brinker, C Jeffrey; Bradbury, Andrew R M; Arap, Wadih; Pasqualini, Renata

2016-10-28

Nanomedicines have significant potential for cancer treatment. Although the majority of nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome-based nanocarriers, their widespread use is limited by non-specificity and low target site concentration and thus, do not provide a substantial clinical advantage over conventional, systemic chemotherapy. In the past 20years, we have identified specific receptors expressed on the surfaces of tumor endothelial and perivascular cells, tumor cells, the extracellular matrix and stromal cells using combinatorial peptide libraries displayed on bacteriophage. These studies corroborate the notion that unique receptor proteins such as IL-11Rα, GRP78, EphA5, among others, are differentially overexpressed in tumors and present opportunities to deliver tumor-specific therapeutic drugs. By using peptides that bind to tumor-specific cell-surface receptors, therapeutic agents such as apoptotic peptides, suicide genes, imaging dyes or chemotherapeutics can be precisely and systemically delivered to reduce tumor growth in vivo, without harming healthy cells. Given the clinical applicability of peptide-based therapeutics, targeted delivery of nanocarriers loaded with therapeutic cargos seems plausible. We propose a modular design of a functionalized protocell in which a tumor-targeting moiety, such as a peptide or recombinant human antibody single chain variable fragment (scFv), is conjugated to a lipid bilayer surrounding a silica-based nanocarrier core containing a protected therapeutic cargo. The functionalized protocell can be tailored to a specific cancer subtype and treatment regimen by exchanging the tumor-targeting moiety and/or therapeutic cargo or used in combination to create unique, theranostic agents. In this review, we summarize the identification of tumor-specific receptors through combinatorial phage display technology and the use of antibody display selection to identify recombinant human sc

Tumor targeting using liposomal antineoplastic drugs

Directory of Open Access Journals (Sweden)

Jörg Huwyler

2008-03-01

Full Text Available Jörg Huwyler1, Jürgen Drewe2, Stephan Krähenbühl21University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland; 2Department of Research and Division of Clinical Pharmacology, University Hospital Basel, Basel, SwitzerlandAbstract: During the last years, liposomes (microparticulate phospholipid vesicles have beenused with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumordrugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.Keywords: tumor targeting, antineoplastic drugs, liposomes, pegylation, steric stabilization, immunoliposomes

Sensemaking technology

DEFF Research Database (Denmark)

Madsen, Charlotte Øland

Research objective: The object of the LOK research project is to gain a better understanding of the technological strategic processes in organisations by using the concept/metaphor of sensemaking. The project will investigate the technological strategies in organisations in order to gain a deeper...... understanding of the cognitive competencies and barriers towards implementing new technology in organisations. The research will therefore concentrate on researching the development process in the organisation's perception of the external environmental elements of customers, suppliers, competitors, internal...... and external technology and legislation and the internal environmental elements of structure, power relations and political arenas. All of these variables have influence on which/how technologies are implemented thus creating different outcomes all depending on the social dynamics that are triggered by changes...

Radioactive target and source development at Argonne National Laboratory

International Nuclear Information System (INIS)

Greene, J.P.; Ahmad, I.; Thomas, G.E.

1992-01-01

An increased demand for low-level radioactive targets has created the need for a laboratory dedicated to the production of these foils. A description is given of the radioactive target produced as well as source development work being performed at the Physics Division target facility of Argonne National Laboratory (ANL). Highlights include equipment used and the techniques employed. In addition, some examples of recent source preparation are given as well as work currently in progress

How to Create Business Value through Information Technology (A Case Study on Automotive Production

Directory of Open Access Journals (Sweden)

Kamran Feizi

2018-03-01

Full Text Available This study aimed at designing information technology business value model in order to explain the value of information technology in business and evaluate information technology contribution in organization function. For the purpose of a comprehensive analysis of the subject using qualitative data, the research method was set to be mixed method focusing on qualitative sequential design. The first stage of the research strategy was an exploratory single case study and for the second phase, the researchers used focus groups design. Saipa Corporation, one of the most famous firms in Iranian automotive industry, was selected as the case. The varied qualitative date were gathered through interview, document review and observation methods and were analyzed afterwards. Ultimately, the findings of the study highlighted the items and dimensions of information technology business value. This model is composed of the relationship between different dimensions of the theoretical models regarding and the share of information technology in building a business. In order to ensure research generalizability, the results of the research were compared with those in the literature review and the theoretic adequacy of the proposed framework was confirmed.

Creating and shaping innovation systems: Formal networks in the innovation system for stationary fuel cells in Germany

International Nuclear Information System (INIS)

Musiolik, Joerg; Markard, Jochen

2011-01-01

The development and diffusion of novel technologies, e.g. for decentralized energy generation, crucially depends on supportive institutional structures such as R and D programs, specific regulations, technical standards, or positive expectations. Such structures are not given but emerge through the interplay of different kinds of actors. In this paper, we study the role of formal networks in creating supportive structures in the technological innovation system for stationary fuel cells in Germany. Our findings are based on an in-depth study of five selected innovation networks. The analysis shows that the networks were strategically set up to support the creation of a variety of elements including public R and D programs, modules for vocational training, technical guidelines, standardized components, or a positive image of the technology. These elements have been reported to generate positive externalities in the field, e.g. as they help to establish user-supplier linkages in the emerging value chain. We conclude that, from a firm perspective such elements may represent strategically relevant resources made available at the innovation system level. This view opens up a link to the literature of strategic management, thus highlighting the importance of strategic action and cooperation in emerging technological fields. - Research Highlights: → We combine technological innovation systems with resource-based reasoning. → Formal networks are strategically set up to create and shape technological innovation systems. → Formal networks create system resources which provide positive externalities in emerging fields. → Collective action is essential for the build-up of energy innovation systems.

Creating and shaping innovation systems: Formal networks in the innovation system for stationary fuel cells in Germany

Energy Technology Data Exchange (ETDEWEB)

Musiolik, Joerg, E-mail: joerg.musiolik@eawag.c [Cirus - Innovation Research in Utility Sectors, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Duebendorf (Switzerland); Markard, Jochen [Cirus - Innovation Research in Utility Sectors, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Duebendorf (Switzerland)

2011-04-15

The development and diffusion of novel technologies, e.g. for decentralized energy generation, crucially depends on supportive institutional structures such as R and D programs, specific regulations, technical standards, or positive expectations. Such structures are not given but emerge through the interplay of different kinds of actors. In this paper, we study the role of formal networks in creating supportive structures in the technological innovation system for stationary fuel cells in Germany. Our findings are based on an in-depth study of five selected innovation networks. The analysis shows that the networks were strategically set up to support the creation of a variety of elements including public R and D programs, modules for vocational training, technical guidelines, standardized components, or a positive image of the technology. These elements have been reported to generate positive externalities in the field, e.g. as they help to establish user-supplier linkages in the emerging value chain. We conclude that, from a firm perspective such elements may represent strategically relevant resources made available at the innovation system level. This view opens up a link to the literature of strategic management, thus highlighting the importance of strategic action and cooperation in emerging technological fields. - Research Highlights: {yields} We combine technological innovation systems with resource-based reasoning. {yields} Formal networks are strategically set up to create and shape technological innovation systems. {yields} Formal networks create system resources which provide positive externalities in emerging fields. {yields} Collective action is essential for the build-up of energy innovation systems.

Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning.

Science.gov (United States)

Ploch, Caitlin C; Mansi, Chris S S A; Jayamohan, Jayaratnam; Kuhl, Ellen

2016-06-01

Three-dimensional (3D) printing holds promise for a wide variety of biomedical applications, from surgical planning, practicing, and teaching to creating implantable devices. The growth of this cheap and easy additive manufacturing technology in orthopedic, plastic, and vascular surgery has been explosive; however, its potential in the field of neurosurgery remains underexplored. A major limitation is that current technologies are unable to directly print ultrasoft materials like human brain tissue. In this technical note, the authors present a new technology to create deformable, personalized models of the human brain. The method combines 3D printing, molding, and casting to create a physiologically, anatomically, and tactilely realistic model based on magnetic resonance images. Created from soft gelatin, the model is easy to produce, cost-efficient, durable, and orders of magnitude softer than conventionally printed 3D models. The personalized brain model cost $50, and its fabrication took 24 hours. In mechanical tests, the model stiffness (E = 25.29 ± 2.68 kPa) was 5 orders of magnitude softer than common 3D printed materials, and less than an order of magnitude stiffer than mammalian brain tissue (E = 2.64 ± 0.40 kPa). In a multicenter surgical survey, model size (100.00%), visual appearance (83.33%), and surgical anatomy (81.25%) were perceived as very realistic. The model was perceived as very useful for patient illustration (85.00%), teaching (94.44%), learning (100.00%), surgical training (95.00%), and preoperative planning (95.00%). With minor refinements, personalized, deformable brain models created via 3D printing will improve surgical training and preoperative planning with the ultimate goal to provide accurate, customized, high-precision treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

The Spanish CEIDEN Technology Platform: Activities on Knowledge Management

International Nuclear Information System (INIS)

Velasco, R.; Montero, A.; Ruiz, F.; Leon, P.

2016-01-01

Full text: CEIDEN is a Spanish organization for the coordination of the needs and efforts on nuclear fission research and development (R&D). It was created in 1999 and since 2007 has the status of technology platform. The main functions of CEIDEN are to define and develop joint R&D projects, and to present a common position for national and international commitments and proposals in the nuclear fission R&D field. With around one hundred of Spanish members and a significant number of foreign collaborative entities, CEIDEN groups all sectors involved in this field. In 2011 the CEIDEN F+ permanent group was created to cope with the E&T issues. The main objectives of F+ are to promote the coordination of E&T programmes in a national level and to support the Spanish participation in international networks, programmes and projects in this field. Knowledge management is more and more a paramount issue that conditions the future of the Spanish nuclear sector, especially all the related to the generational replacement. In response to this challenge, a nuclear knowledge management group has been created recently in CEIDEN with the target of start coordinated initiatives in the Spanish nuclear sector, in this field. (author

Transmutation technology development; thermal hydraulic power analysis and structure analysis of the HYPER target beam window

Energy Technology Data Exchange (ETDEWEB)

Choi, J. H.; Ju, E. S.; Song, M. K.; Jeon, Y. Z. [Gyeongsang National University, Jinju (Korea)

2002-03-01

A thermal hydraulic power analysis, a structure analysis and optimization computation for some design factor for the design of spallation target suitable for HYPER with 1000 MW thermal power in this study was performed. Heat generation formula was used which was evaluated recently based on the LAHET code, mainly to find the maximum beam current under given computation conditions. Thermal hydraulic power of HYPER target system was calculated using FLUENT code, structure conducted by inputting the data into ANSYS. On the temp of beam windows and the pressure distribution calculated using FLUENT. Data transformation program was composed apply the data calculated using FLUENT being commercial CFD code and ANSYS being FEM code for CFX structure analysis. A basic study was conducted on various singular target to obtain fundamental data on the shape for optimum target design. A thermal hydraulic power analysis and structure analysis were conducted on the shapes of parabolic, uniform, scanning beams to choose the optimum shape of beam current analysis was done according to some turbulent model to simulate the real flow. To evaluate the reliability of numerical analysis result, benchmarking of FLUENT code reformed at SNU and Korea Advanced Institute of Science and Technology and it was compared to CFX in the possession of Korea Atomic Energy Research Institute and evaluated. Reliable deviation was observed in the results calculated using FLUENT code, but temperature deviation of about 200 .deg. C was observed in the result from CFX analysis at optimum design condition. Several benchmarking were performed on the basis of numerical analysis concerning conventional HYPER. It was possible to allow a beam arrests of 17.3 mA in the case of the {phi} 350 mm parabolic beam suggested to the optimum in nuclear transmutation when stress equivalent to VON-MISES was calculated to be 140 MPa. 29 refs., 109 figs. (Author)

Bilgi Teknolojilerinin Yattığı Örgütsel Değişim: Nasıl Bir İnsan Kaynakları Yönetimi / Organizational Change Created by Information Technologies : The Type of Corresponding Human Resources Management

Directory of Open Access Journals (Sweden)

Beyhan Aksoy

2005-04-01

Full Text Available The role of information technologies with all its dimensions in creating an organizational change is an important contemporary topic. Human resources management in terms of recruitment, placement, training, performance evaluation and compensation has all been influenced by the organizational change being generated by the information technologies. The present paper discusses the mentioned effects. Afterwards, the effects were observed upon a case study provided by a technology-intense firm and cituation of this firm has been evaluated in this circumtances.

Cost-Efficient and Sustainable Deployment of Renewable Energy Sources towards the 20% Target by 2020, and beyond. D5.3. Key recommendations from the RES4LESS roadmap

Energy Technology Data Exchange (ETDEWEB)

Dalla Longa, F. [ECN Policy Studies, Amsterdam (Netherlands); Raimundo, C. [IT Power, Bristol, Avon (United Kingdom)

2012-12-15

In its Directive 2009/28/EC the European Commission (EC) set an ambitious 20% target on the final consumption of energy from renewable sources (RES) in 2020 (European Commission, 2009). This EU-level target is divided into different domestic targets for each single Member State (MS). The MS-level targets do not always reflect the domestic RES potentials, creating a situation where certain MSs will have to deploy very expensive technologies in order to meet their target, while other countries are expected to reach their target at lower costs and even produce a RES surplus. In order to promote a more balanced distribution of costs, the Directive allows MSs to establish cooperation mechanisms. Three types of cooperation mechanisms are defined: a MS could buy the RES-credits associated with the surplus potential of other MSs via statistical transfers, could finance additional RES deployment in other MSs by engaging in joint projects, or could share (part of) its RES potential with other MSs by establishing joint support schemes.

Specific genetic modifications of domestic animals by gene targeting and animal cloning

Directory of Open Access Journals (Sweden)

Zhou Jiangfeng

2003-11-01

Full Text Available Abstract The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large livestock species until the successful creation of the first mammalian clone "Dolly" the sheep. The combination of the technologies for gene targeting of somatic cells with those of animal cloning made it possible to introduce specific genetic mutations into domestic animals. In this review, the principles of gene targeting in somatic cells and the challenges of nuclear transfer using gene-targeted cells are discussed. The relevance of gene targeting in domestic animals for applications in bio-medicine and agriculture are also examined.

ICF target technology at the Russian Federal Nuclear Center

International Nuclear Information System (INIS)

Veselov, A.V.; Drozhin, V.S.; Druzhinin, A.A.; Izgorodin, V.M.; Iiyushechkin, B.N.; Kirillov, G.A.; Komleva, G.V.; Korochkin, A.M.; Medvedev, E.F.; Nikolaev, G.P.; Pikulin, I.V.; Pinegin, A.V.; Punin, V.T.; Romaev, V.N.; Sumatokhin, V.L.; Tarasova, N.N.; Tachaev, G.V.; Cherkesova, I.N.

1995-01-01

The main effort of the ICF target fabrication group is support of the experiments performed on the 'ISKRA-4' and 'ISKRA-5' laser systems. The main types of targets used in these experiments are direct drive, inverted corona, and indirect drive. For production of direct drive targets, manufacturing techniques have been developed for both hollow glass and polystyrene microspheres. Hollow glass microspheres are fabricated by free-fall of liquid glass drops or dry gel in a 4 meter vertical kiln. These methods allow us to manufacture glass microspheres with diameters from 50 μm to 1 mm, wall thicknesses from 0.5 to 10 μm, and aspect ratios (radius/ wall) from 20 to 500. The microspheres have a thickness inhomogeneity less than 5% and non-sphericity less than 1%. Polystyrene microspheres are fabricated from polystyrene particles with a blowing agent in a similar vertical kiln. Polystyrene microspheres are fabricated with diameter up to 800 μm and wall thicknesses from 1 to 10 μm. 15 refs., 8 figs

Study on laser beam welding technology for nuclear power plants title

International Nuclear Information System (INIS)

Chida, Itaru; Shiihara, Katsunori; Fukuda, Takeshi; Kono, Wataru; Obata, Minoru; Morishima, Yasuo

2011-01-01

Laser beam welding is one of the jointing processes by irradiating laser beam on the material surface locally and widely used at various industrial fields. Toshiba has developed various laser-based maintenance and repair technologies and already applied them to several existing nuclear power plants. Laser cladding is a technique to weld the corrosion resistant metal onto a substrate surface by feeding filler wire to improve the corrosion resistance. Temper-bead welding is the heat input process to provide the desired microstructure properties of welded low alloy steels without post weld heat treatment, by inducing proper heat cycle during laser welding. Both laser welding technologies would be performed underwater by blowing the shielding gas for creating the local dry area. In this report, some evaluation results of material characteristics by temper-bead welding to target at Reactor Coolant System nozzle of PWR are presented. (author)

Gene targeting and cloning in pigs using fetal liver derived cells.

Science.gov (United States)

Waghmare, Sanjeev K; Estrada, Jose; Reyes, Luz; Li, Ping; Ivary, Bess; Sidner, Richard A; Burlak, Chris; Tector, A Joseph

2011-12-01

Since there are no pig embryonic stem cells, pig genetic engineering is done in fetal fibroblasts that remain totipotent for only 3 to 5 wk. Nuclear donor cells that remain totipotent for longer periods of time would facilitate complicated genetic engineering in pigs. The goal of this study was to test the feasibility of using fetal liver-derived cells (FLDC) to perform gene targeting, and create a genetic knockout pig. FLDC were isolated and processed using a human liver stem cell protocol. Single copy α-1,3-galactosyl transferase knockout (GTKO) FLDCs were created using electroporation and neomycin resistant colonies were screened using PCR. Homozygous GTKO cells were created through loss of heterozygosity mutations in single GTKO FLDCs. Double GTKO FLDCs were used in somatic cell nuclear transfer (SCNT) to create GTKO pigs. FLDCs grew for more than 80 population doublings, maintaining normal karyotype. Gene targeting and loss of heterozygosity mutations produced homozygous GTKO FLDCs. FLDCs used in SCNT gave rise to homozygous GTKO pigs. FDLCs can be used in gene targeting and SCNT to produce genetically modified pigs. The increased life span in culture compared to fetal fibroblasts may facilitate genetic engineering in the pig. Copyright © 2011 Elsevier Inc. All rights reserved.

Creating innovative programs for the future.

Science.gov (United States)

Allen, Patricia E; Keough, Vicki A; Armstrong, Myrna L

2013-09-01

Although several major national mandates advocate for a better educated workforce, this push comes at a time when the competition for faculty, financial resources, advanced technology, and students remains strong. If nurse educators are seriously considering creating a new nurse program at their school, some key points are essential during the development stage. Using the innovation frameworks from the Institute of Healthcare Improvement, from the global design firm IDEO, and from Gladwell's The Tipping Point: How Little Things Can Make a Big Difference, this article examines the informal, formal, internal, and external work needed during program conceptualization, initial program exploration, resource infrastructure, support, and evaluation for an effective and innovative plan. Copyright 2013, SLACK Incorporated.

CLOUD-BASED PLATFORM FOR CREATING AND SHARING WEB MAPS

Directory of Open Access Journals (Sweden)

Jean Pierre Gatera

2014-01-01

Full Text Available The rise of cloud computing is one the most important thing happening in information technology today. While many things are moving into the cloud, this trend has also reached the Geographic Information System (GIS world. For the users of GIS technology, the cloud opens new possibilities for sharing web maps, applications and spatial data. The goal of this presentation/demo is to demonstrate ArcGIS Online which is a cloud-based collaborative platform that allows to easily and quickly create interactive web maps that you can share with anyone. With ready-to-use content, apps, and templates you can produce web maps right away. And no matter what you use - desktops, browsers, smartphones, or tablets - you always have access to your content.

Competitiveness and Management of Technology

OpenAIRE

Cheng, Ming Yu

2015-01-01

This paper delves into competition and technology management as a means of economic development. Expanding from Porter's framework on competitiveness and using a novel framework of PTGE（People, Technology, Government and Environment）, this paper argues that three types of competitive advantage could be created. These competitive advantages range from passive to active advantages, i.e. natural advantage, duplicated advantage and niche advantage. Technology and effective management of technolog...

Low carbon and clean energy scenarios for India: Analysis of targets approach

International Nuclear Information System (INIS)

Shukla, Priyadarshi R.; Chaturvedi, Vaibhav

2012-01-01

Low carbon energy technologies are of increasing importance to India for reducing emissions and diversifying its energy supply mix. Using GCAM, an integrated assessment model, this paper analyzes a targets approach for pushing solar, wind, and nuclear technologies in the Indian electricity generation sector from 2005 to 2095. Targets for these technologies have been constructed on the basis of Indian government documents, policy announcements, and expert opinions. Different targets have been set for the reference scenario and the carbon price scenario. In the reference scenario, wind and nuclear technologies exceed respective targets in the long run without any subsidy push, while solar energy requires subsidy push throughout the century in order to meet its high targets. In the short run, nuclear energy also requires significant subsidy, including a much higher initial subsidy relative to solar power, which is a result of its higher targets. Under a carbon price scenario, the carbon price drives the penetration of these technologies. Still, subsidy is required — especially in the short run when the carbon price is low. We also found that pushing solar, wind, and nuclear technologies leads to a decrease in share of CCS under the carbon price scenario and biomass under both the reference and carbon price scenarios. This is because low carbon technologies compete among themselves and substitute each other, thereby enhancing the need for subsidy or carbon price, highlighting that proposed targets are not set at efficient levels. In light of contemporary debate on external costs of nuclear energy, we also assess the sensitivity of the results to nuclear technology cost. We find that higher cost significantly decreases the share of nuclear power under both the reference and carbon price scenarios.

CONDITIONS AND ORGANIZATION OF THE TRANSITION TO BASIC TECHNOLOGIES OF A NEW TECHNOLOGICAL STRUCTURE

Directory of Open Access Journals (Sweden)

B. L. Bourov

2011-01-01

Full Text Available With due account for the coming new (VI-th world technological structure, future creation of new types of industrial production is both possible and necessary. Economic environment conditions favorable for such development are designated. In reference to Russian technological environment particulars, self-developing economic-technological microenvironment of a new quality level should be created in zones where controlled «technological chains» function. Possibilities of creation of the VI-th technological structure level basic technologies are shown for industrial and household waste processing techniques as an example.

What factors determine therapists' acceptance of new technologies for rehabilitation – a study using the Unified Theory of Acceptance and Use of Technology (UTAUT).

Science.gov (United States)

Liu, Lili; Miguel Cruz, Antonio; Rios Rincon, Adriana; Buttar, Vickie; Ranson, Quentin; Goertzen, Darrell

2015-01-01

The aim of this study was to examine what factors affect the acceptance behavior and use of new technologies for rehabilitation by therapists at a large rehabilitation hospital in Canada. A self-administrated paper-based survey was created by adapting scales with high levels of internal consistency in prior research using the Unified Theory of Acceptance and Use of Technology (UTAUT). Items were scored on a 7-point Likert scale, ranging from "strongly disagree (1)" to "strongly agree (7)". The target population was all occupational therapists (OT) and physical therapists (PT) involved with the provision of therapeutic interventions at the hospital. Our research model was tested using partial least squares (PLS) technique. Performance expectancy was the strongest salient construct for behavioral intention to use new technologies in rehabilitation, whereas neither effort expectancy nor social influence were salient constructs for behavioral intention to use new technologies; (4) facilitating condition and behavioral intention to use new technologies were salient constructs for current use of new technologies in rehabilitation, with facilitating condition the strongest salient for current use of new technologies in rehabilitation. In a large rehabilitation hospital where use of new technologies in rehabilitation is not mandatory, performance expectancy, or how the technology can help in therapists' work, was the most important factor in determining therapists' acceptance and use of technologies. However, effort expectancy and social influence constructs were not important, i.e. therapists were not influenced by the degree of difficulty or social pressures to use technologies. Behavioral intention and facilitating condition, or institutional support, are related to current use of new technologies in rehabilitation.

Soulful Technologies

DEFF Research Database (Denmark)

Fausing, Bent

2010-01-01

Samsung introduced in 2008 a mobile phone called "Soul" made with a human touch and including itself a "magic touch". Through the analysis of a Nokia mobile phone TV-commercials I want to examine the function and form of digital technology in everyday images. The mobile phone and its digital camera...... and other devices are depicted by everyday aesthetics as capable of producing a unique human presence and interaction. The medium, the technology is a necessary helper of this very special and lost humanity. Without the technology, no special humanity, no soul - such is the prophecy. This personification...... or anthropomorphism is important for the branding of new technology. Technology is seen as creating a techno-transcendence towards a more qualified humanity which is in contact with fundamental human values like intuition, vision, and sensing; all the qualities that technology, industrialization, and rationalization...

Creating informed public opinion: citizen deliberation about nanotechnologies for human enhancements

International Nuclear Information System (INIS)

Cobb, Michael D.

2011-01-01

Many people believe that ordinary citizens should influence scientific and technological developments, but the American public is routinely uninformed about these issues. As a solution, some scholars advocate creating informed public opinions by encouraging citizens to deliberate about the issues. Although this idea is currently widely applauded in the science and technology literature, deliberative outcomes are infrequently measured and the practice of deliberation is routinely criticized in other disciplines. This research contributes to our understanding of the effectiveness of citizen deliberation as a method for increasing public engagement with science. I report data measuring results of deliberation in a national citizens’ technology forum (NCTF) about nanotechnologies for human enhancement. The NCTF was a month-long process involving six groups of 9–15 ordinary citizens who deliberated in different locations across the United States with the goal of reaching consensus about policy recommendations within their groups. I find that structured deliberation generated informed opinions, sometimes meaningful shifts in preferences, and increased trust and internal efficacy among the participants. Nevertheless, the NCTF has important shortcomings, and it is not obvious that consensus conferences should be preferred over other mechanisms for creating informed opinions. Future research is needed to corroborate the findings of this study and to systematically compare outcomes of structured citizen deliberation to other less resource intensive forms of engagement.

Are Emojis Creating a New or Old Visual Language for New Generations? A Socio-Semiotic Study

Science.gov (United States)

Alshenqeeti, Hamza

2016-01-01

The increasing use of emojis, digital images that can represent a word or feeling in a text or email, and the fact that they can be strung together to create a sentence with real and full meaning raises the question of whether they are creating a new language amongst technologically savvy youth, or devaluing existing language. There is however a…

Characterizing the technology firm : An exploratory study

NARCIS (Netherlands)

Grinstein, A.; Goldman, Arieh

Technology firms occupy a central position in modern economies. They drive economic growth, productivity gains and have created new industries and innovative products. Many will agree that technology firms are distinguished from others in their emphasis on technological activities. Since this

Disproportionality as a Framework to Target Pollution Reduction from Urban Landscapes

Directory of Open Access Journals (Sweden)

Brian Horgan

2008-01-01

Full Text Available New federal water quality regulations regarding impaired waters and urban stormwater, alongside a growing need to reverse eutrophication of urban lakes, are creating demand to decrease nutrient export from urban landscapes, particularly lawns. We propose that Nowak et al.’s (2006 disproportionality framework could be used to target specific households likely to generate disproportionate levels of nutrient export. The biophysical dimension would be based on landscape vulnerability (slope, soil type, proximity to lakes; the social dimension would target “inappropriate” lawn management behaviors leading to high nutrient export on these vulnerable landscapes. Understanding of lawn nutrient cycling (biophysical dimension and homeowner beliefs and attitudes (social dimension would be used to develop targeted, specific messages for homeowners practicing inappropriate management. A lawn management program developed with this disproportionality framework would probably be very effective, highly economical and fair, targeting only homeowners who are creating a disproportionate impact.

Identification of creat (Andrographis paniculata Ness as basic for concervation and make use of germ plasm

Directory of Open Access Journals (Sweden)

BAMBANG PUJIASMANTO

2007-07-01

Full Text Available This research is to learn the creat potention for cultivated as medical material producer plant. So that, the limited creat as medical material not occur. The method of research which used is survey. The survai include identification and creat distribution pattern. There was used vegetative analysis with quadrat method. The research result showed that 1 in creat habitat find out 11 species of tree, 20 species herba (include creat, and 16 species grasses, 2 The highest of importance value indeks Tectona grandis L. (tree group, Andrographis paniculata Ness (herb group, and Portulaca oleraceae L. (grasses group, 3 Distribution pattern of creat is clumped, and the herb others is uniform, 4 The creat growth on the common under shading Tectona grandis L. tree. The results of this research are domestication concept and theories which to basic the cultivated technology packet of creat wild plant which the statue increased be medical material produce crop. In the next ,expected can used for get conclusion policy of medical crop and planning, especially on creat propertion of creat medical material.

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

Directory of Open Access Journals (Sweden)

Hongguang Sun

2014-01-01

Full Text Available Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar to antibodies, aptamers interact with their targets by recognizing a specific three-dimensional structure and are thus termed “chemical antibodies.” In contrast to protein antibodies, aptamers offer unique chemical and biological characteristics based on their oligonucleotide properties. Hence, they are more suitable for the development of novel clinical applications. Aptamer technology has been widely investigated in various biomedical fields for biomarker discovery, in vitro diagnosis, in vivo imaging, and targeted therapy. This review will discuss the potential applications of aptamer technology as a new tool for targeted cancer therapy with emphasis on the development of aptamers that are able to specifically target cell surface biomarkers. Additionally, we will describe several approaches for the use of aptamers in targeted therapeutics, including aptamer-drug conjugation, aptamer-nanoparticle conjugation, aptamer-mediated targeted gene therapy, aptamer-mediated immunotherapy, and aptamer-mediated biotherapy.

On the selection of financing instruments to push the development of new technologies: Application to clean energy technologies

International Nuclear Information System (INIS)

Olmos, Luis; Ruester, Sophia; Liong, Siok-Jen

2012-01-01

Achieving climate policy goals requires mobilizing public funds to bring still immature clean technologies to competitiveness and create new technological options. The format of direct public support must be tailored to the characteristics of technologies addressed. Based on the experience accumulated with innovation programs, we have identified those features of innovation that should directly condition the choice of direct support instruments. These include the funding gap between the cost of innovation activities and the amount of private funds leveraged; the ability of technologies targeted to compete for public funds in the market; the probability that these technologies fail to reach the market; and the type of entity best suited to conduct these activities. Clean innovation features are matched to those of direct support instruments to provide recommendations on the use to be made of each type of instrument. Given the large financing gap of most clean energy innovation projects, public grants and contracts should finance a large part of clean pre-deployment innovation. However, public loans, equity investments, prizes and tax credits or rebates can successfully support certain innovation processes at a lower public cost. Principles derived are applied to identify the instrument best suited to a case example. - Highlights: ► Public financing instruments must be tailored to the features of supported innovation. ► Instruments should trigger desired innovation at the lowest public cost possible. ► They should strike the right balance between technology selection and competition. ► Public funds mobilized through them should reach the innovating entity. ► Public loans, equity investments, prizes, and rebates should be used in specific cases.

The role of the CSIR/WRC Sanitation Technology Demonstration Centre in creating awareness, sharing information and in decision-making regarding sanitation technologies

CSIR Research Space (South Africa)

Mema, V

2010-09-01

Full Text Available sanitation technologies platform exhibits wet sanitation technologies (e.g. septic tanks, pour flush toilet unit) which may generally be constructed within a building. Wet sanitation technologies are all the sanitation technologies that require water... to wash down faeces from the pedestal either to a septic tank or centralised treatment works. In decentralised treatment systems like septic tanks, the treatment of wastewater occurs at a localised treatment facility close to the source of waste...

Research and development achievement report for fiscal 1998 on accelerated type biological function construction technologies. Development of new-type advanced-function enzyme creating technologies; 1998 nendo kasokugata seibutsu kino kochiku gijutsu no kenkyu kaihatsu seika hokokusho. Shingata kokino koso sosei gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

An artificial mutation/selection system was constructed in a laboratory based on molecular-level findings collected about the biological evolution mechanism, and biotechnology was studied for creating excellent biological functions. In the study of novel mutation generating technologies, selection is performed after the formation of numerous chimera enzymes by a family shuffling process using resistance to heat as the index. Then, a hybrid enzyme with its resistance to heat more than 10 times higher than that of the parent enzyme was obtained. In the study of establishing coordination between genotype and phenotype, a highly sensitive bacterial coordination technology was developed, and a highly sensitive detection method was constructed using a flow cytometer. As for technologies of highly efficient selection, a research was conducted about the selection of catalytic antibodies equipped with protease and esterase activity. In the study of technologies for enhancing adaptive walk in an evolution experimenting system, the usefulness is studied of a terrain survey based on the adaptive walk theory and a high-efficiency adaptive walk method using the mutation scrambling method. (NEDO)

Developing and evaluating rare disease educational materials co-created by expert clinicians and patients

DEFF Research Database (Denmark)

Badiu, Corin; Bonomi, Marco; Borshchevsky, Ivan

2017-01-01

were conducted by clinicians and patients who are native speakers. RESULTS: Co-created patient education materials reached the target 6th grade reading level according to 2/6 (33%) algorithms (range: grade 5.9-9.7). The online survey received 164 hits in 2 months and 63/159 (40%) of eligible patients...... disease patients. Combining dissemination via traditional healthcare professional platforms as well as patient-centric sites can facilitate broad uptake of culturally adapted translations. This process may serve as a roadmap for creating patient education materials for other rare diseases....

Solar Photovoltaic Technology Basics | NREL

Science.gov (United States)

Photovoltaic Technology Basics Solar Photovoltaic Technology Basics Solar cells, also called found in sand) created an electric charge when exposed to sunlight. Soon solar cells were being used to power space satellites and smaller items like calculators and watches. Photo of a large silicon solar

A Career in Laser Technology.

Science.gov (United States)

Burns, William E.

1986-01-01

The increased expansion of laser technology will create many new jobs and will require workers with many different skills. At the same time, some kinds of occupations will be adversely affected, due to increasing use of laser technology in a broad range of industries. (CT)

Configuring the users of new HIV-prevention technologies: the case of HIV pre-exposure prophylaxis.

Science.gov (United States)

Holt, Martin

2015-01-01

HIV pre-exposure prophylaxis (PrEP) is a prevention technology that involves prescribing antiretroviral drugs to HIV-negative people to protect them from infection. This paper considers how the development of the technology has necessitated the parallel configuration of its users, and how this process has affected the perception and uptake of the technology. In designing a technology, potential users are typically defined, enabled and constrained, partly to create a target population (or market) for the technology, but also to reassure people that it can be used safely and effectively. This process may or may not be helpful for the uptake and use of the technology. Published research on PrEP indicates that while the technology was under trial, the primary focus was on the 'at-risk' subject in need of PrEP, with little or no consideration of the other qualities necessary for successful use. Post-trial accounts of PrEP have begun to outline desirable qualities of successful PrEP use, such as caution, compliance and being organised. It appears that the PrEP user was only partially configured during the technology's development, and the initial focus on risk has done little to counter fears of the technology, which may partially account for its slow uptake.

Additional risk of end-of-the-pipe geoengineering technologies

Science.gov (United States)

Bohle, Martin

2014-05-01

Humans are engineers, even the artists who engineer the surface of the globe. Should humans endeavour to engineer the Earth to counter climate change hazards? Striving towards 'global sustainability' will require to adjust the current production and consumption patterns. Contrary to an approach of global sustainability, 'geoengineering' deploys a 'technology fix' for the same purpose. Humans are much inclined to look for technological fixes for problems because well engineered technological methods have created modern societies. Thus, it seems obvious to apply an engineering solution to climate change issues too. In particular, as air pollution causing acid rains has been reduced by cleaner combustion processes or ozone destructing chemical coolants have been replaced by other substances. Common to these approaches was to reduce inputs into global or regional systems by withholding emission, replacing substances or limiting use cases for certain substances. Thus, the selected approach was a technological fix or regulatory measure targeting the 'start of the pipe'. However applying a 'start of the pipe' approach to climate change faces the issue that mankind should reduce inputs were its hurts, namely reducing radically energy that is produced from burning fossil fuels. Capping burning of fossil fuels would be disruptive for the economic structures or the consumption pattern of the developed and developing industrialised societies. Facing that dilemma, affordable geoengineering looks tempting for some. However geoengineering technologies, which counter climate change by other means than carbon capture at combustion, are of a different nature than the technological fixes and negotiated regulatory actions, which so far have been applied to limit threats to regional and global systems. Most of the proposed technologies target other parts of the climate system but the carbon-dioxide input into the atmosphere. Therefore, many geoengineering technologies differ

New type of metal targets

International Nuclear Information System (INIS)

Bukharov, A.V.; Ankudinov, V.B.; Ogorodnikov, V.P.; Marukhin, Y.A.

2014-01-01

Now the technologies based on interaction of high-intensity beams with substance of a target are being intensively developed. As a target it is possible to use the new type of monodisperse metal targets. The principal advantages of new targets type are: target cooling isn't required; there is no induced activity: the target can be used many times; small dispersion on the speed, the size and interaction points with a beam. The basis of a target is the jet of molten metal, following in the vacuum chamber .Under the influence of the special disturbance superimposed on the liquid jet, the jet disintegrated into identical drops. In the vacuum chamber the drops freeze and form into the solid granules. It is possible to receive monodisperse targets from different metals, alloys and salts (diameter of targets is from 30 .m to 1.5 mm). Dispersion by the sizes and speed is less than 1%. The technique allows to receive not only continuous targets, but also hollow targets with dispersion on thickness of wall within 1...2%.

Optoelectronics technologies for Virtual Reality systems

Science.gov (United States)

Piszczek, Marek; Maciejewski, Marcin; Pomianek, Mateusz; Szustakowski, Mieczysław

2017-08-01

Solutions in the field of virtual reality are very strongly associated with optoelectronic technologies. This applies to both process design and operation of VR applications. Technologies such as 360 cameras and 3D scanners significantly improve the design work. What is more, HMD displays with high field of view or optoelectronic Motion Capture systems and 3D cameras guarantee an extraordinary experience in immersive VR applications. This article reviews selected technologies from the perspective of their use in a broadly defined process of creating and implementing solutions for virtual reality. There is also the ability to create, modify and adapt new approaches that show team own work (SteamVR tracker). Most of the introduced examples are effectively used by authors to create different VR applications. The use of optoelectronic technology in virtual reality is presented in terms of design and operation of the system as well as referring to specific applications. Designers and users of VR systems should take a close look on new optoelectronics solutions, as they can significantly contribute to increased work efficiency and offer completely new opportunities for virtual world reception.

Fabrication of laser-target components by semiconductor technology

International Nuclear Information System (INIS)

Tindall, W.E.

1979-01-01

This paper describes the design and fabrication of a unique silicon substrate with which laser-target components can be mass produced. Different sizes and shapes of gold foils from 50 to 3000 microns in diameter and up to 25 microns thick have been produced with this process since 1976

Learning About Energy Resources Through Student Created Video Documentaries in the University Science Classroom

Science.gov (United States)

Wade, P.; Courtney, A.

2010-12-01

Students enrolled in an undergraduate non-science majors’ Energy Perspectives course created 10-15 minute video documentaries on topics related to Energy Resources and the Environment. Video project topics included wave, biodiesel, clean coal, hydro, solar and “off-the-grid” energy technologies. No student had any prior experience with creating video projects. Students had Liberal Arts academic backgrounds that included Anthropology, Theater Arts, International Studies, English and Early Childhood Education. Students were required to: 1) select a topic, 2) conduct research, 3) write a narrative, 4) construct a project storyboard, 5) shoot or acquire video and photos (from legal sources), 6) record the narrative, and 7) construct the video documentary. This study describes the instructional approach of using student created video documentaries as projects in an undergraduate non-science majors’ science course. Two knowledge survey instruments were used for assessment purposes. Each instrument was administered Pre-, Mid- and Post course. One survey focused on the skills necessary to research and produce video documentaries. Results showed students acquired enhanced technology skills especially with regard to research techniques, writing skills and video editing. The second survey assessed students’ content knowledge acquired from each documentary. Results indicated students’ increased their content knowledge of energy resource topics. Students reported very favorable evaluations concerning their experience with creating “Ken Burns” video project documentaries.

Technology Education in Preschool: Providing Opportunities for Children to Use Artifacts and to Create

Science.gov (United States)

Sundqvist, Pernilla; Nilsson, Tor

2018-01-01

In recent years, technology has been emphasized as an important area in early childhood curricula; however, in many countries preschool does not have the tradition of teaching specific subjects, and research shows that many preschool staff members are unsure about what teaching technology should include and how it should be taught. Therefore, with…

Toward a new information infrastructure in health technology assessment: communication, design, process, and results.

Science.gov (United States)

Neikter, Susanna Allgurin; Rehnqvist, Nina; Rosén, Måns; Dahlgren, Helena

2009-12-01

The aim of this study was to facilitate effective internal and external communication of an international network and to explore how to support communication and work processes in health technology assessment (HTA). STRUCTURE AND METHODS: European network for Health Technology Assessment (EUnetHTA) connected sixty-four HTA Partner organizations from thirty-three countries. User needs in the different steps of the HTA process were the starting point for developing an information system. A step-wise, interdisciplinary, creative approach was used in developing practical tools. An Information Platform facilitated the exchange of scientific information between Partners and with external target groups. More than 200 virtual meetings were set up during the project using an e-meeting tool. A Clearinghouse prototype was developed with the intent to offering a single point of access to HTA relevant information. This evolved into a next step not planned from the outset: Developing a running HTA Information System including several Web-based tools to support communication and daily HTA processes. A communication strategy guided the communication effort, focusing on practical tools, creating added value, involving stakeholders, and avoiding duplication of effort. Modern technology enables a new information infrastructure for HTA. The potential of information and communication technology was used as a strategic tool. Several target groups were represented among the Partners, which supported collaboration and made it easier to identify user needs. A distinctive visual identity made it easier to gain and maintain visibility on a limited budget.

Creating value: unifying silos into public health business intelligence.

Science.gov (United States)

Davidson, Arthur J

2014-01-01

Through September 2014, federal investments in health information technology have been unprecedented, with more than 25 billion dollars in incentive funds distributed to eligible hospitals and providers. Over 85 percent of eligible United States hospitals and 60 percent of eligible providers have used certified electronic health record (EHR) technology and received Meaningful Use incentive funds (HITECH Act1). Certified EHR technology could create new public health (PH) value through novel and rapidly evolving data-use opportunities, never before experienced by PH. The long-standing "silo" approach to funding has fragmented PH programs and departments,2 but the components for integrated business intelligence (i.e., tools and applications to help users make informed decisions) and maximally reuse data are available now. Challenges faced by PH agencies on the road to integration are plentiful, but an emphasis on PH systems and services research (PHSSR) may identify gaps and solutions for the PH community to address. Technology and system approaches to leverage this information explosion to support a transformed health care system and population health are proposed. By optimizing this information opportunity, PH can play a greater role in the learning health system.

Polarized targets in high energy physics

Energy Technology Data Exchange (ETDEWEB)

Cates, G.D. Jr. [Princeton Univ., NJ (United States)

1994-12-01

Various approaches are discussed for producing polarized nuclear targets for high energy physics experiments. As a unifying theme, examples are drawn from experiments to measure spin dependent structure functions of nucleons in deep inelastic scattering. This single physics goal has, over roughly two decades, been a driving force in advances in target technology. Actual or planned approaches have included solid targets polarized by dynamic nuclear polarization (DNP), several types of internal targets for use in storage rings, and gaseous {sup 3}He targets polarized by spin-exchange optical pumping. This last approach is the type of target adopted for SLAC E-142, an experiment to measure the spin structure function of the neutron, and is described in detail.

Polarized targets in high energy physics

International Nuclear Information System (INIS)

Cates, G.D. Jr.

1994-01-01

Various approaches are discussed for producing polarized nuclear targets for high energy physics experiments. As a unifying theme, examples are drawn from experiments to measure spin dependent structure functions of nucleons in deep inelastic scattering. This single physics goal has, over roughly two decades, been a driving force in advances in target technology. Actual or planned approaches have included solid targets polarized by dynamic nuclear polarization (DNP), several types of internal targets for use in storage rings, and gaseous 3 He targets polarized by spin-exchange optical pumping. This last approach is the type of target adopted for SLAC E-142, an experiment to measure the spin structure function of the neutron, and is described in detail

Fiscal 1999 achievement report. Important regional technology research and development--Advanced machining technology for high-melting point metal based members (Development of creating technology for high-efficiency power generating members); 1999 nendo koyuten kinzokukei buzai no kodo kako gijutsu seika hokokusho. Kokoritsu hatsuden'yo buzai sosei gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

Research and development is conducted concerning technologies of creating high-melting point metal based members for the purpose of enabling gas turbines to withstand still higher temperatures. In the research which deals mainly with Nb, solid solution state is enhanced, high-temperature strength and tenacity are improved by enhanced composition and diffusion, and surfaces are modified in terms of resistance to oxidation and corrosion by the technologies of multi-layer coating and slope-structured coating. In the designing and evaluation of high-strength Nb based solid solution alloys, alloys excellent in high-temperature strength and room-temperature tenacity are obtained, which contain 5-30at% Mo and 5-15at% W. In the designing and evaluation of Nb based composite materials, it is found that it strengthens the composition of Nb based enhanced solid solution alloys to add Si to Nb alloys for the precipitation of silicides in the Nb based solid solution alloy matrices. In the study of the creation technology for and evaluation of Nb based ultrahigh-temperature members, experiments are conducted with attention focused on the discharge plasma sintering method. In the development of technologies for providing oxidation resisting capability, studies are conducted about ion implantation and ion plating. (NEDO)

Target Detection Based on EBPSK Satellite Passive Radar

Directory of Open Access Journals (Sweden)

Lu Zeyuan

2015-05-01

Full Text Available Passive radar is a topic anti stealth technology with simple structure, and low cost. Radiation source model, signal transmission model, and target detection are the key points of passive radar technology research. The paper analyzes the characteristics of EBPSK signal modulation and target detection method aspect of spaceborne radiant source. By comparison with other satellite navigation and positioning system, the characteristics of EBPSK satellite passive radar system are analyzed. It is proved that the maximum detection range of EBPSK satellite signal can satisfy the needs of the proposed model. In the passive radar model, sparse representation is used to achieve high resolution DOA detection. The comparison with the real target track by simulation demonstrates that effective detection of airborne target using EBPSK satellite passive radar system based on sparse representation is efficient.

Characterizing Health Information for Different Target Audiences.

Science.gov (United States)

Sun, Yueping; Hou, Zhen; Hou, Li; Li, Jiao

2015-01-01

Different groups of audiences in health care: health professionals and health consumers, each have different information needs. Health monographs targeting different audiences are created by leveraging readers' background knowledge. The NCI's Physician Data Query (PDQ®) Cancer Information Summaries provide parallel cancer information and education resources with different target audiences. In this paper, we used targeted audience-specific cancer information PDQs to measure characteristic differences on the element level between audiences. In addition, we compared vocabulary coverage. Results show a significant difference between the professional and patient version of cancer monographs in both content organization and vocabulary. This study provides a new view to assess targeted audience-specific health information, and helps editors to improve the quality and readability of health information.

Creating an Authentic Learning Environment in the Foreign Language Classroom

Directory of Open Access Journals (Sweden)

Larisa Nikitina

2011-01-01

Full Text Available Theatrical activities are widely used by language educators to promote and facilitate language learning. Involving students in production of their own video or a short movie in the target language allows a seamless fusion of language learning, art, and popular culture. The activity is also conducive for creating an authentic learning situation where the real world becomes a part of the educational experience and necessitates the use of an authentic language by the learners. This article describes a video project carried out by Russian language learners at Universiti Malaysia Sabah (UMS. It examines how the work on the project created and supported authenticity of the learning experience. Though the article focuses on the video project done in the context of language learning and teaching this activity could be successfully implemented in teaching various subjects at both secondary and tertiary levels.

Fiscal 1999 research report on long-term energy technology strategy. Basic research on industrial technology strategy (Individual technology strategy (Textile technology field)); 1999 nendo choki energy gijutsu senryku nado ni kansuru chosa hokokusho. Sangyo gijutsu senryaku sakutei kiban chosa (bun'yabetsu gijutsu senryaku (sen'i gijutsu bun'ya))

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

This report summarizes the fiscal 1999 basic research result on industrial technology strategy of a textile technology field. Social demand and constraint in the 21st century restrict human life and industrial activity, however, include huge business chances. This technology strategy aims at construction of textile business contributing to the society, and improvement of the international competitiveness of Japanese textile industry. Analysis was made on the current international competitiveness of the textile industry in comparison between Japanese and American productivity. As factors hindering technological innovation, the following were pointed out: poor cooperation among industry, academia and government, poor cooperation among different kinds of industries, poor preparation of basic technology, knowledge base and creation base, and poor deregulation. As the future target and strategy, 7 technology targets, 2 creation targets, and every target year were showed. 4 proposals were also showed as follows: preparation of a technology base, creation base, talent education and knowledge base, and protection of intellectual property rights. (NEDO)

NATURAL BARRIERS TARGETED THRUST FY 2004 PROJECTS

International Nuclear Information System (INIS)

NA

2005-01-01

This booklet contains project descriptions of work performed by the Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM), Office of Science and Technology and International's (OSTandI) Natural Barriers Targeted Thrust during Fiscal Year (FY) 2004. The Natural Barriers Targeted Thrust is part of OSTandI's Science and Technology Program which supports the OCRWM mission to manage and dispose of high-level radioactive waste and spent nuclear fuel in a manner that protects health, safety, and the environment; enhances national and energy security; and merits public confidence. In general, the projects described will continue beyond FY 2004 assuming that the technical work remains relevant to the proposed Yucca Mountain Repository and sufficient funding is made available to the Science and Technology Program

[Changing the teaching of neurosurgery with information technology].

Science.gov (United States)

Moreau, Jean-Jacques; Caire, François; Kalamarides, Michel; Mireau, Etienne; Dauger, Frédéric; Coignac, Marie-Jo; Charlin, Bernard

2009-10-01

A digital campus is a distance learning site that uses the potential of information and communication technologies to disseminate and improve educational services. This website, with open and free access, is built from free software with Web 2.0 technology. It is hosted at the University of Limoges. It functions as a digital library, containing scanned books, slide shows, more than 200 hours of recorded courses and round tables accessible by streaming video. The site is indexed according to the users' needs, by level of knowledge, specialty, keywords, and supplementary MeSH terms. The campus is organized as the College of Neurosurgery (http://college.neurochirurgie.fr). The durability of this type of training (in existence for 9 years now) is made possible by a powerful and committed consortium: the French Society of Neurosurgery, which has created high-quality intellectual and scientific resources, the University of Limoges, the Dupuytren University Hospital Center in Limoges, the region of Limousin, and the French-language Virtual Medical University, which have provided logistic and financial support. To target appropriate levels at various users, we distinguished four groups: medical students, neurosurgery students, neurosurgeons (continuing medical education), and students in allied health fields. All areas of neurosurgery are concerned. All the courses, including tests for self-evaluation and scientific meetings (organized with information and communication technologies) are digitally recorded for the site. The principles that make it possible for a medical discipline to organize around an online project are: a pedagogical conception of projects built in the form of models reusable by other health specialties; a stronghold within professional societies of the relevant specialties able to create high-quality intellectual and scientific resources; an organization by educational levels that can be extended transversally to other health disciplines; and free

Dynamic effects of interaction of composite projectiles with targets

Energy Technology Data Exchange (ETDEWEB)

Zakharov, V. M. [Scientific Research Institute of Applied Mathematics and Mechanics of Tomsk State University, 36, Lenin Avenue, Tomsk, 634050 (Russian Federation)

2016-01-15

The process of high-speed impact of projectiles against targets of finite thickness is experimentally investigated. Medium-hard steel plates are used as targets. The objective of this research is to carry out a comparative analysis of dynamic effects of interaction of various types of projectiles with targets, such as characteristics of destruction of the target, the state of the projectile behind the target, and particularities of the after-penetration stream of fragments after the target has been pierced. The projectiles are made of composites on the basis of tungsten carbide obtained by caking and the SHS-technology. To compare effectiveness of composite projectiles steel projectiles are used. Their effectiveness was estimated in terms of the ballistic limit. High density projectiles obtained by means of the SHS-technology are shown to produce results comparable in terms of the ballistic limit with high-strength projectiles that contain tungsten received by caking.

Preservice Science Teachers' Perceptions of Their TPACK Development after Creating Digital Stories

Science.gov (United States)

Sancar-Tokmak, Hatice; Surmeli, Hikmet; Ozgelen, Sinan

2014-01-01

The aim of this case study was to examine pre-service science teachers' (PSTs) perceptions of their Technological Pedagogical Content Knowledge (TPACK) development after creating digital stories based on science topics drawn from the national curriculum. A total of 21 PSTs enrolled in Introduction to Computers II participated in the study. Data…

More Efficient Operations of the Company with the Help of Communication Technologies

Directory of Open Access Journals (Sweden)

Tešić Mirjana

2016-12-01

Full Text Available The success of the modern enterprise depends not only on its ability to develop a good product / service, to form an adequate price and your offer makes available to customers, but also on how to communicate with the target audience. For the management of modern enterprises, including small and medium-sized enterprises (SMEs, is a major challenge that all activities are carried out in a proper manner and that adds value to which the various interested stakeholders. In recent times, are very important, and information and communication systems in the new economy because the rapid technological progress in the ICT sector started the process of creating a new economy, a new growth and economic development. Successful management is increasingly based on interactive communication and the adopting of marketing communication new technologies, all of which contribute to more efficient business for a company.

Proceedings of the workshop on polarized targets in storage rings

International Nuclear Information System (INIS)

Holt, R.J.

1984-08-01

Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base

Value Creation, Appropriation, and Product Design Strategies in Technology Ecosystems: Three Essays on the Role of Complementary Technologies

Science.gov (United States)

Miller, Cameron Dee

2017-01-01

Firms are often embedded in a technology ecosystem comprised of complementary technologies that span multiple product markets. In this dissertation, I examine how complementarity between the firm's technologies influences its strategies to create and appropriate value in the ecosystem. I investigate this overarching question in two contexts:…

Physics and high technology

International Nuclear Information System (INIS)

Shao Liqin; Ma Junru.

1992-01-01

At present, the development of high technology has opened a new chapter in world's history of science and technology. This review describes the great impact of physics on high technology in six different fields (energy technology, new materials, information technology, biotechnology, space technology, and Ocean technology). It is shown that the new concepts and new methods created in physics and the special conditions and measurements established for physics researches not only deepen human's knowledge about nature but also point out new directions for engineering and technology. The achievements in physics have been more and more applied to high technology, while the development of high technology has explored some new research areas and raised many novel, important projects for physics. Therefore, it is important for us to strengthen the research on these major problems in physics

Recombinant innovation and endogenous technological transitions

NARCIS (Netherlands)

Frenken, K.; Izquierdo, L.R.; Zeppini, P.

2012-01-01

We propose a model of technological transitions based on two different types of innovations. Branching innovations refer to technological improvements along a particular path, while recombinant innovations represent fusions of multiple paths. Recombinant innovations create "short-cuts" which reduce

Doppler electron velocimetry : notes on creating a practical tool.

Energy Technology Data Exchange (ETDEWEB)

Reu, Phillip L.; Milster, Tom (University of Arizona)

2008-11-01

The Doppler electron velocimeter (DEV) has been shown to be theoretically possible. This report attempts to answer the next logical question: Is it a practical instrument? The answer hinges upon whether enough electrons are available to create a time-varying Doppler current to be measured by a detector with enough sensitivity and bandwidth. The answer to both of these questions is a qualified yes. A target Doppler frequency of 1 MHz was set as a minimum rate of interest. At this target a theoretical beam current signal-to-noise ratio of 25-to-1 is shown for existing electron holography equipment. A detector is also demonstrated with a bandwidth of 1-MHz at a current of 10 pA. Additionally, a Linnik-type interferometer that would increase the available beam current is shown that would offer a more flexible arrangement for Doppler electron measurements over the traditional biprism.

As Technologies for Nucleotide Therapeutics Mature, Products Emerge.

Science.gov (United States)

Beierlein, Jennifer M; McNamee, Laura M; Ledley, Fred D

2017-12-15

The long path from initial research on oligonucleotide therapies to approval of antisense products is not unfamiliar. This lag resembles those encountered with monoclonal antibodies, gene therapies, and many biological targets and is consistent with studies of innovation showing that technology maturation is a critical determinant of product success. We previously described an analytical model for the maturation of biomedical research, demonstrating that the efficiency of targeted and biological development is connected to metrics of technology growth. The present work applies this model to characterize the advance of oligonucleotide therapeutics. We show that recent oligonucleotide product approvals incorporate technologies and targets that are past the established point of technology growth, as do most of the oligonucleotide products currently in phase 3. Less mature oligonucleotide technologies, such as miRNAs and some novel gene targets, have not passed the established point and have not yielded products. This analysis shows that oligonucleotide product development has followed largely predictable patterns of innovation. While technology maturation alone does not ensure success, these data show that many oligonucleotide technologies are sufficiently mature to be considered part of the arsenal for therapeutic development. These results demonstrate the importance of technology assessment in strategic management of biomedical technologies. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Study On Technology Based Home Vision Screening And Creating Awareness On Eye Health

Directory of Open Access Journals (Sweden)

Nirav Mehta

2015-08-01

Full Text Available Introduction Technology is one of most important factor in todays life. IPAD is leading as people can make use of technology by just pressing buttons. Networking technology and education makes communication easier and helps people in easy education and awareness. Aim amp objectives The main aim of the study is to educate and aware among people regarding eye health and the check the visual function of their eye by using Apple I pad. Material and Methodology The following study is a home based vision screening program using IPAD which uses the basic tests like visual acuity color vision contrast sensitivity and amsler tests for checking the basic functions of the eye. The study was performed in many societies moving from one place to another using IPAD as a tool. Reliability of ipad was checked a pilot study on 25 subjects visual acuity colour vision and contrast sensitivity was taken on both ipad and Original chart like snellen ishihara and pellirobson and compared in which the results and the accuracy were same. The study also contains questionnaire on the awareness and education about eye health. The subjects included in the study were an age group of 10 to 70. Subjects like infants and blind were not included in the study. Results During the study it was observed that there is no significant difference in testing of visual acuity between ipad and Snellen standard chart. The subjects responded actively towards screening and that home vision screening can be possible. During the study it was found that 40 subjects out of 100 needed further detailed check-up and were referred in Rotary eye hospital hospital but only 3 out of 40 came for it. This shows that they are less aware and education about their eye health. Software used in IPAD were visual acuity color vision contrast sensitivity and amsler tests A questionnaire was also asked which indicated less awareness among the common people. Conclusion We examined with just an ipad and not an

Girls Creating Games: Challenging Existing Assumptions about Game Content

OpenAIRE

Denner, Jill

2005-01-01

In a reinforcing cycle, few females create games, and fewer girls than boys play games. According to the Interactive Digital Software Association’s 2003 survey, 72% of all video game players are male. This is unfortunate, as early game playing not only fosters specific cognitive and motor skills (Subrahmanyam, Kraut, Greenfield, & Gross, 2000), it is also a gateway to shaping the future of technology. How can we better attract, engage, and sustain the interests of girls in gaming? One str...

Technology Transfer Strategies for Creating Growth Opportunities in Frontier Markets of Sub-Saharan Africa

DEFF Research Database (Denmark)

Nielsen, Ulrik B.

In the past decade, Africa has developed from being an extremely impoverished continent with discouraging prospects to a more promising destination and home to some of the fastest growing Frontier Market economies. Approximately 75% of Africans rely on agriculture for their livelihoods, making...... to create growth opportunities in Frontier Markets of Sub-Saharan Africa....

Targeted intraoperative radiotherapy in oncology

CERN Document Server

Keshtgar, Mohammed; Wenz, Frederik

2014-01-01

Targeted intraoperative radiotherapy is a major advance in the management of cancer patients. With an emphasis on practical aspects, this book offers an ideal introduction to this innovative  technology for clinicians.

Role of the CSIR/WRC Sanitation Technology Demonstration Centre in creating awareness, sharing information and in decision-making regarding sanitation technologies

CSIR Research Space (South Africa)

Mema, V

2010-09-01

Full Text Available The CSIR and the Water Research Commission (WRC) have envisioned a Sanitation Technology Demonstration Centre to provide a cutting-edge environment for bringing to light old and new, as well as promising sanitation technologies. The purpose...

Agile science: creating useful products for behavior change in the real world.

Science.gov (United States)

Hekler, Eric B; Klasnja, Predrag; Riley, William T; Buman, Matthew P; Huberty, Jennifer; Rivera, Daniel E; Martin, Cesar A

2016-06-01

Evidence-based practice is important for behavioral interventions but there is debate on how best to support real-world behavior change. The purpose of this paper is to define products and a preliminary process for efficiently and adaptively creating and curating a knowledge base for behavior change for real-world implementation. We look to evidence-based practice suggestions and draw parallels to software development. We argue to target three products: (1) the smallest, meaningful, self-contained, and repurposable behavior change modules of an intervention; (2) "computational models" that define the interaction between modules, individuals, and context; and (3) "personalization" algorithms, which are decision rules for intervention adaptation. The "agile science" process includes a generation phase whereby contender operational definitions and constructs of the three products are created and assessed for feasibility and an evaluation phase, whereby effect size estimates/casual inferences are created. The process emphasizes early-and-often sharing. If correct, agile science could enable a more robust knowledge base for behavior change.

Creating a testing field where delta technology and water innovations are tested and demonstrated with the help of citizen science methods

Science.gov (United States)

de Vries, Sandra; Rutten, Martine; de Vries, Liselotte; Anema, Kim; Klop, Tanja; Kaspersma, Judith

2017-04-01

In highly populated deltas, much work is to be done. Complex problems ask for new and knowledge driven solutions. Innovations in delta technology and water can bring relief to managing the water rich urban areas. Testing fields form a fundamental part of the knowledge valorisation for such innovations. In such testing fields, product development by start-ups is coupled with researchers, thus supplying new scientific insights. With the help of tests, demonstrations and large-scale applications by the end-users, these innovations find their way to the daily practices of delta management. More and more cities embrace the concept of Smart Cities to tackle the ongoing complexity of urban problems and to manage the city's assets - such as its water supply networks and other water management infrastructure. Through the use of new technologies and innovative systems, data are collected from and with citizens and devices - then processed and analysed. The information and knowledge gathered are keys to enabling a better quality of life. By testing water innovations together with citizens in order to find solutions for water management problems, not only highly spatial amounts of data are provided by and/or about these innovations, they are also improved and demonstrated to the public. A consortium consisting of a water authority, a science centre, a valorisation program and two universities have joined forces to create a testing field for delta technology and water innovations using citizen science methods. In this testing field, the use of citizen science for water technologies is researched and validated by facilitating pilot projects. In these projects, researchers, start-ups and citizens work together to find the answer to present-day water management problems. The above mentioned testing field tests the use of crowd-sourcing data as for example hydrological model inputs, or to validate remote sensing applications, or improve water management decisions. Currently the

Poster – 39: Using Optical Scanner and 3D Printer Technology to Create Lead Shielding for Radiotherapy of Facial Skin Cancer with Low Energy Photons

International Nuclear Information System (INIS)

Rickey, Daniel; Leylek, Ahmet; Dubey, Arbind; Sasaki, David; Harris, Chad; Butler, Jim; Sharma, Ankur; McCurdy, Boyd; Alpuche Aviles, Jorge E.

2016-01-01

Purpose: Treatment of skin cancers of the face using orthovoltage radiotherapy often requires lead shielding. However, creating a lead shield can be difficult because the face has complex and intricate contours. The traditional process involved creating a plaster mould of the patient’s face can be difficult for patients. Our goal was to develop an improved process by using an optical scanner and 3D printer technology. Methods: The oncologist defined the treatment field by drawing on each patient’s skin. Three-dimensional images were acquired using a consumer-grade optical scanner. A 3D model of each patient’s face was processed with mesh editing software before being printed on a 3D printer. Using a hammer, a 3 mm thick layer of lead was formed to closely fit the contours of the model. A hole was then cut out to define the field. Results: The lead shields created were remarkably accurate and fit the contours of the patients. The hole defining the field exposed only a minimally sized site to be exposed to radiation, while the rest of the face was protected. It was easy to obtain perfect symmetry for the definition of parallel opposed beams. Conclusion: We are routinely using this technique to build lead shielding that wraps around the patient as an alternative to cut-outs. We also use it for treatment of the tip of the nose using a parallel opposed pair beams with a wax nose block. We found this technique allows more accurate delineation of the cut-out and a more reproducible set-up.

Poster – 39: Using Optical Scanner and 3D Printer Technology to Create Lead Shielding for Radiotherapy of Facial Skin Cancer with Low Energy Photons

Energy Technology Data Exchange (ETDEWEB)

Rickey, Daniel; Leylek, Ahmet; Dubey, Arbind; Sasaki, David; Harris, Chad; Butler, Jim; Sharma, Ankur; McCurdy, Boyd; Alpuche Aviles, Jorge E. [CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba, CancerCare Manitoba (Canada)

2016-08-15

Purpose: Treatment of skin cancers of the face using orthovoltage radiotherapy often requires lead shielding. However, creating a lead shield can be difficult because the face has complex and intricate contours. The traditional process involved creating a plaster mould of the patient’s face can be difficult for patients. Our goal was to develop an improved process by using an optical scanner and 3D printer technology. Methods: The oncologist defined the treatment field by drawing on each patient’s skin. Three-dimensional images were acquired using a consumer-grade optical scanner. A 3D model of each patient’s face was processed with mesh editing software before being printed on a 3D printer. Using a hammer, a 3 mm thick layer of lead was formed to closely fit the contours of the model. A hole was then cut out to define the field. Results: The lead shields created were remarkably accurate and fit the contours of the patients. The hole defining the field exposed only a minimally sized site to be exposed to radiation, while the rest of the face was protected. It was easy to obtain perfect symmetry for the definition of parallel opposed beams. Conclusion: We are routinely using this technique to build lead shielding that wraps around the patient as an alternative to cut-outs. We also use it for treatment of the tip of the nose using a parallel opposed pair beams with a wax nose block. We found this technique allows more accurate delineation of the cut-out and a more reproducible set-up.

Integration of intracellular telomerase monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive oxygen species.

Science.gov (United States)

Zhang, Huairong; Li, Binxiao; Sun, Zhaomei; Zhou, Hong; Zhang, Shusheng

2017-12-01

Cancer therapies based on reactive oxygen species (ROS) have emerged as promising clinical treatments. Electrochemiluminescence (ECL) technology has also attracted considerable attention in the field of clinical diagnosis. However, studies about the integration of ECL diagnosis and ROS cancer therapy are very rare. Here we introduce a novel strategy that employs ECL technology and ROS to fill the above vacancy. Briefly, an ITO electrode was electrodeposited with polyluminol-Pt NPs composite films and modified with aptamer DNA to capture HL-60 cancer cells with high specificity. After that, mesoporous silica nanoparticles (MSNs) filled with phorbol 12-myristate 13-acetate (PMA) were closed by the telomerase primer DNA (T-primer DNA) and aptamer. After aptamer on MSN@PMA recognized and combined with the HL-60 cancer cells with high specificity, T-primer DNA on MSN@PMA could be moved away from the MSN@PMA surface after extension by telomerase in the HL-60 cancer cells and PMA was released to induce the production of ROS by the HL-60 cancer cells. After that, the polyluminol-Pt NPs composite films could react with hydrogen peroxide (a major ROS) and generate an ECL signal. Thus the intracellular telomerase activity of the HL-60 cancer cells could be detected in situ . Besides, ROS could induce apoptosis in the HL-60 cancer cells with high efficacy by causing oxidative damage to the lipids, protein, and DNA. Above all, the designed platform could not only detect intracellular telomerase activity instead of that of extracted telomerase, but could also kill targeted tumors by ECL technology and ROS.

Accelerator and neutron targets: a survey

International Nuclear Information System (INIS)

Kobisk, E.H.

1974-01-01

Although advances in electronics, ion source physics, detector technology, and other technical aspects of accelerator science have resulted in the capability of making highly sophisticated and accurate measurements of nuclear and atomic properties, the significance of such measurements is frequently dictated by the form, composition, and other characteristics of the target containing the nuclear species being studied. Consideration must be given to the impurity content, number of isotope nuclei per unit area, uniformity of nuclei distribution in the target, physical strength of the target, and myriad other factors. Most target characteristics are related to the mode(s) of preparation and to the quality of isotopic material used. A wide variety of target types and associated preparative methods are described and evaluated, together with methods of target characterization

Inclusive design and anthropological methods to create technological support for societal inclusion

NARCIS (Netherlands)

Cremers, A.H.M.; Jansen, Y.J.F.M.; Neerincx, M.A.; Schouten, D.; Kayal, A.

2014-01-01

Large groups in society lack the necessary skills to be sufficiently self-reliant and are in need of personal assistance. They include ageing people, people with low literacy skills, non-natives, but also children. They could all be supported by information and communication technology (ICT), but

INNOVATIVE TECHNOLOGICAL SOLUTIONS IN CREATING FUNCTIONAL PRODUCTS POWER

Directory of Open Access Journals (Sweden)

I. V. Sergienko

2015-01-01

Full Text Available The article deals with a problem of functional products creation for consumers feeling need in proteins, irreplaceable amino acids, vitamins, mineral substances, food fibers, polynonsaturated fat acids. One of the possible ways to improve human nutrition is using non-traditional cultures for bread making technology containing significant amounts of fibrous substances, easily digestible protein, vitamins, unsaturated fatty acids and minerals. Taking into account the Nutrition Science requirements an expediency of the most full functional ingredients complex entering into bakery products prescription structure is proved. Replacement of the first grade wheat flour by the offered prescription composition allows to slow down a bread aging, to increase periods of products storage and to improve their physical and chemical indicators on the specific volume and porosity. The bakery products "Svyatogor" at the use of 100 g of a product allow to cover daily need in protein for 38,9%, in carbohydrates – for 3,4%, fat – for 9,2%. The power value of "Svyatogor" is 897 kJ, in control 959. Biological value, % 82,7 against 53,1 in control. Thanks to it the digestibility of bread protein (in vitro method of “Svyatogor” is higher. Thanks to unique properties of the compounding components “Svyatogor” gets functional properties by full-fledged protein increasing and its best comprehensibility (in vitro, advanced structure according to the content of vitamins, mineral substances, their balanced structure and can be recommended for mass consumption and prevention of osteoporosis, atherosclerosis, anemia, for children food, pregnant women and the feeding women.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT LASER TOUCH AND TECHNOLOGIES, LLC LASER TOUCH MODEL LT-B512

Science.gov (United States)

The Environmental Technology Verification report discusses the technology and performance of Laser Touch model LT-B512 targeting device manufactured by Laser Touch and Technologies, LLC, for manual spray painting operations. The relative transfer efficiency (TE) improved an avera...

Create Your Plate

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Full Text Available ... Plate Share Create Your Plate ! Share: Seven Simple Steps to Create Your Plate It's simple and effective ... foods within each food category. Try these seven steps to get started: Using your dinner plate, put ...

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Effect of repeat purchase and dynamic market size on diffusion of an innovative technological consumer product in a segmented market

DEFF Research Database (Denmark)

Aggarwal, S.; Gupta, A.; Govindan, K.

2014-01-01

creates a spectrum effect in market with an aim to create wider product awareness and influence the market size. Whereas the differentiated promotion strategy plays major role in external influence component in the respective segment and target for adoption by the current potential segment. Previous......This study develops diffusion models for technological consumer products under the marketing environment when a product is marketed in a segmented market and observes two distinctive promotional strategies of mass and differentiated promotion; an under explored study area. Mass promotion strategy...... studies on segmented diffusion models assumed only first time purchase and constant market size which may yield underestimated results and fail to give appropriate insight of the diffusion process. The study develops and validates generalized diffusion models for segmented market incorporating...

3D-Printing Technologies for Craniofacial Rehabilitation, Reconstruction, and Regeneration.

Science.gov (United States)

Nyberg, Ethan L; Farris, Ashley L; Hung, Ben P; Dias, Miguel; Garcia, Juan R; Dorafshar, Amir H; Grayson, Warren L

2017-01-01

The treatment of craniofacial defects can present many challenges due to the variety of tissue-specific requirements and the complexity of anatomical structures in that region. 3D-printing technologies provide clinicians, engineers and scientists with the ability to create patient-specific solutions for craniofacial defects. Currently, there are three key strategies that utilize these technologies to restore both appearance and function to patients: rehabilitation, reconstruction and regeneration. In rehabilitation, 3D-printing can be used to create prostheses to replace or cover damaged tissues. Reconstruction, through plastic surgery, can also leverage 3D-printing technologies to create custom cutting guides, fixation devices, practice models and implanted medical devices to improve patient outcomes. Regeneration of tissue attempts to replace defects with biological materials. 3D-printing can be used to create either scaffolds or living, cellular constructs to signal tissue-forming cells to regenerate defect regions. By integrating these three approaches, 3D-printing technologies afford the opportunity to develop personalized treatment plans and design-driven manufacturing solutions to improve aesthetic and functional outcomes for patients with craniofacial defects.

Smart Technology Applications in Business Environments

NARCIS (Netherlands)

Issa, Tomayess; Kommers, Petrus A.M.; Issa, Theodora; Isaías, Pedro; Issa, Touma B.

2017-01-01

Technology continues to make great strides in society by providing opportunities for advancement, inclusion, and global competency. As new systems and tools arise, novel applications are created as well. Smart Technology Applications in Business Environments is an essential reference source for the

HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

Science.gov (United States)

Moens, Lotte N J; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; Sundström, Magnus; La Fleur, Linnéa; Mathot, Lucy; Micke, Patrick; Nilsson, Mats; Botling, Johan

2015-11-01

In recent years, the advent of massively parallel next-generation sequencing technologies has enabled substantial advances in the study of human diseases. Combined with targeted DNA enrichment methods, high sequence coverage can be obtained for different genes simultaneously at a reduced cost per sample, creating unique opportunities for clinical cancer diagnostics. However, the formalin-fixed, paraffin-embedded (FFPE) process of tissue samples, routinely used in pathology departments, results in DNA fragmentation and nucleotide modifications that introduce a number of technical challenges for downstream biomolecular analyses. We evaluated the HaloPlex target enrichment system for somatic mutation detection in 80 tissue fractions derived from 20 clinical cancer cases with paired tumor and normal tissue available in both FFPE and fresh-frozen format. Several modifications to the standard method were introduced, including a reduced target fragment length and two strand capturing. We found that FFPE material can be used for HaloPlex-based target enrichment and next-generation sequencing, even when starting from small amounts of DNA. By specifically capturing both strands for each target fragment, we were able to reduce the number of false-positive errors caused by FFPE-induced artifacts and lower the detection limit for somatic mutations. We believe that the HaloPlex method presented here will be broadly applicable as a tool for somatic mutation detection in clinical cancer settings. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

NATURAL BARRIERS TARGETED THRUST FY 2004 PROJECTS

Energy Technology Data Exchange (ETDEWEB)

NA

2005-07-27

This booklet contains project descriptions of work performed by the Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM), Office of Science and Technology and International's (OST&I) Natural Barriers Targeted Thrust during Fiscal Year (FY) 2004. The Natural Barriers Targeted Thrust is part of OST&I's Science and Technology Program which supports the OCRWM mission to manage and dispose of high-level radioactive waste and spent nuclear fuel in a manner that protects health, safety, and the environment; enhances national and energy security; and merits public confidence. In general, the projects described will continue beyond FY 2004 assuming that the technical work remains relevant to the proposed Yucca Mountain Repository and sufficient funding is made available to the Science and Technology Program.

Radar cross-section (RCS) analysis of high frequency surface wave radar targets

OpenAIRE

ÇAKIR, Gonca; SEVGİ, Levent

2010-01-01

Realistic high frequency surface wave radar (HFSWR) targets are investigated numerically in terms of electromagnetic wave -- target interactions. Radar cross sections (RCS) of these targets are simulated via both the finite-difference time-domain (FDTD) method and the Method of Moments (MoM). The virtual RCS prediction tool that was introduced in previous work is used for these investigations. The virtual tool automatically creates the discrete FDTD model of the target under investi...

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.

NARCIS (Netherlands)

de Groote, M.L.; Verschure, P.J.; Rots, M.G.

2012-01-01

Despite significant advances made in epigenetic research in recent decades, many questions remain unresolved, especially concerning cause and consequence of epigenetic marks with respect to gene expression modulation (GEM). Technologies allowing the targeting of epigenetic enzymes to predetermined

Epigenetic Editing : targeted rewriting of epigenetic marks to modulate expression of selected target genes

NARCIS (Netherlands)

de Groote, Marloes L.; Verschure, Pernette J.; Rots, Marianne G.

2012-01-01

Despite significant advances made in epigenetic research in recent decades, many questions remain unresolved, especially concerning cause and consequence of epigenetic marks with respect to gene expression modulation (GEM). Technologies allowing the targeting of epigenetic enzymes to predetermined

The role of alliances in creating technology legitimacy: a study on the field of bio-plastics

NARCIS (Netherlands)

Kishna, M.J.; Niesten, E.; Negro, S.; Hekkert, M.

2017-01-01

In the transition to a more sustainable world, the development of sustainable technologies needs to be accompanied by promoting the legitimacy of the technologies. Consumers that perceive a technology as desirable and appropriate are more likely to adopt it. Organizations can collaborate to enhance

National Ignition Facility Target Chamber

International Nuclear Information System (INIS)

Wavrik, R W; Cox, J R; Fleming, P J

2000-01-01

On June 11, 1999 the Department of Energy dedicated the single largest piece of the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) in Livermore, California. The ten (10) meter diameter aluminum target high vacuum chamber will serve as the working end of the largest laser in the world. The output of 192 laser beams will converge at the precise center of the chamber. The laser beams will enter the chamber in two by two arrays to illuminate 10 millimeter long gold cylinders called hohlraums enclosing 2 millimeter capsule containing deuterium, tritium and isotopes of hydrogen. The two isotopes will fuse, thereby creating temperatures and pressures resembling those found only inside stars and in detonated nuclear weapons, but on a minute scale. The NIF Project will serve as an essential facility to insure safety and reliability of our nation's nuclear arsenal as well as demonstrating inertial fusion's contribution to creating electrical power. The paper will discuss the requirements that had to be addressed during the design, fabrication and testing of the target chamber. A team from Sandia National Laboratories (SNL) and LLNL with input from industry performed the configuration and basic design of the target chamber. The method of fabrication and construction of the aluminum target chamber was devised by Pitt-Des Moines, Inc. (PDM). PDM also participated in the design of the chamber in areas such as the Target Chamber Realignment and Adjustment System, which would allow realignment of the sphere laser beams in the event of earth settlement or movement from a seismic event. During the fabrication of the target chamber the sphericity tolerances had to be addressed for the individual plates. Procedures were developed for forming, edge preparation and welding of individual plates. Construction plans were developed to allow the field construction of the target chamber to occur parallel to other NIF construction activities. This was

Create Your Plate

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Full Text Available ... Planning Meals > Create Your Plate Share: Print Page Text Size: A A A Listen En Español Create ... Type 2 Education Series Hear audio clips and full recordings of past Q&A events at your ...

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Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call ... Meals > Create Your Plate Share: Print Page Text Size: A A A Listen En Español Create Your ...

Fiscal 1999 project for research and development of industrial and scientific technologies. Report on the achievements on research and development of a technology to structure accelerated type living organism functions (Research on a technology to create a new type high-function enzyme); 1999 nendo kosokugata seibutsu kino kochiku gijutsu no kenkyu kaihatsu seika hokokusho. Shingata kokino koso sosei gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

With an aim at structuring an advancement experimental system that can introduce high-level functions efficiently, development was made on a technology to create new type high-function enzymes. This paper summarizes the achievements in fiscal 1999. In the research of a mutation generating technology, application of the DNA shuffling technology was attempted onto phenol hydroxide enzymes and 2,3-dihydroxybiphenyl 1,2-oxygen added enzymes to discuss the possibility of decomposition of trichloroethylene and decomposition of PCB. In the research of a technology to provide gene type and expression type correspondence, improvement in the vector was studied to increase manifestation of motifs onto bacteria surface so that high-sensitivity detection may be made even on a very small amount of a substance. In the research of an efficient selection technology, studies were made on the catalytic function selecting system and the information function selecting system. In the research of an adaptive walking technology, studies were made on REP, LOD, the advancement experimental system using interaction between proteins as the adaptability, and the multi-dimensional adaptive walking technology. In comprehensive surveys and studies, technological information was exchanged, and discussion meetings were held. (NEDO)

Young Women’s Perceptions of Technology and Engineering: Factors Influencing Their Participation in Math, Science and Technology?

OpenAIRE

Roue, Leah C.

2007-01-01

The current number of women in technology and engineering only represents a fraction of today’s workforce. Technological innovation depends on our nation’s best and brightest, representing all segments of our diverse society. Sanders (2005), in talking about women in technology and engineering, stated that women’s lack of participation can only be measured in jobs not filled, problems not solved, and technology not created. Research in the area of how young women view technology will provide ...

Modelling Recycling Targets

DEFF Research Database (Denmark)

Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

2014-01-01

Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...... the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...

Technology leadership : a road map to commercially viable PEMFC stack technology

Energy Technology Data Exchange (ETDEWEB)

Stone, C. [Ballard Power Systems, Burnaby, BC (Canada)

2005-07-01

This abstract discussed recent advances in stack technology by Ballard Power Systems. The technology department of this Canadian-owned company exhibited the capability of a single proton exchange membrane fuel cell (PEMFC) stack design to demonstrate that cost reduction, freeze start capability from -20 degrees C and durability under an automotive dynamic operating cycle are comparable to that experienced by a fuel cell stack in an actual vehicle. A technology road map has been developed by the company to define a path to the commercial viability of the PEMFC stack by 2010. Key target parameters for cost reduction, durability, freeze start and stack power density were described in detail along with demonstrated historical capability and details of how the company will achieve its required targets. refs., tabs., figs.

Create Your Plate

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Full Text Available ... In Memory In Honor Become a Member En Español Type 1 Type 2 About Us Online Community ... Page Text Size: A A A Listen En Español Create Your Plate Create Your Plate is a ...

Create Your Plate

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Full Text Available ... Planning Meals Diabetes Meal Plans Create Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart- ... Create Your Plate Meal Planning for Vegetarian Diets Gluten Free Diets Holiday Meal Planning Cook with Heart-Healthy Foods ...

Using Information and Communication Technology (ICT) to the Maximum: Learning and Teaching Biology with Limited Digital Technologies

Science.gov (United States)

Van Rooy, Wilhelmina S.

2012-01-01

Background: The ubiquity, availability and exponential growth of digital information and communication technology (ICT) creates unique opportunities for learning and teaching in the senior secondary school biology curriculum. Digital technologies make it possible for emerging disciplinary knowledge and understanding of biological processes…

Comparing Natural Gas Leakage Detection Technologies Using an Open-Source "Virtual Gas Field" Simulator.

Science.gov (United States)

Kemp, Chandler E; Ravikumar, Arvind P; Brandt, Adam R

2016-04-19

We present a tool for modeling the performance of methane leak detection and repair programs that can be used to evaluate the effectiveness of detection technologies and proposed mitigation policies. The tool uses a two-state Markov model to simulate the evolution of methane leakage from an artificial natural gas field. Leaks are created stochastically, drawing from the current understanding of the frequency and size distributions at production facilities. Various leak detection and repair programs can be simulated to determine the rate at which each would identify and repair leaks. Integrating the methane leakage over time enables a meaningful comparison between technologies, using both economic and environmental metrics. We simulate four existing or proposed detection technologies: flame ionization detection, manual infrared camera, automated infrared drone, and distributed detectors. Comparing these four technologies, we found that over 80% of simulated leakage could be mitigated with a positive net present value, although the maximum benefit is realized by selectively targeting larger leaks. Our results show that low-cost leak detection programs can rely on high-cost technology, as long as it is applied in a way that allows for rapid detection of large leaks. Any strategy to reduce leakage should require a careful consideration of the differences between low-cost technologies and low-cost programs.

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

Science.gov (United States)

Joshi, Priyanka; Chia, Sean; Habchi, Johnny; Knowles, Tuomas P J; Dobson, Christopher M; Vendruscolo, Michele

2016-03-14

The aggregation process of intrinsically disordered proteins (IDPs) has been associated with a wide range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Currently, however, no drug in clinical use targets IDP aggregation. To facilitate drug discovery programs in this important and challenging area, we describe a fragment-based approach of generating small-molecule libraries that target specific IDPs. The method is based on the use of molecular fragments extracted from compounds reported in the literature to inhibit of the aggregation of IDPs. These fragments are used to screen existing large generic libraries of small molecules to form smaller libraries specific for given IDPs. We illustrate this approach by describing three distinct small-molecule libraries to target, Aβ, tau, and α-synuclein, which are three IDPs implicated in Alzheimer's and Parkinson's diseases. The strategy described here offers novel opportunities for the identification of effective molecular scaffolds for drug discovery for neurodegenerative disorders and to provide insights into the mechanism of small-molecule binding to IDPs.

Creating Next Generation Blended Learning Environments Using Mixed Reality, Video Games and Simulations

Science.gov (United States)

Kirkley, Sonny E.; Kirkley, Jamie R.

2005-01-01

In this article, the challenges and issues of designing next generation learning environments using current and emerging technologies are addressed. An overview of the issues is provided as well as design principles that support the design of instruction and the overall learning environment. Specific methods for creating cognitively complex,…

Communities of practice: pedagogy and internet-based technologies to support educator's continuing technology professional development in higher education

NARCIS (Netherlands)

Maurice Schols

2011-01-01

Advances in information and communication technologies (ICTs) as well as modern pedagogical perspectives have created new possibilities to facilitate and support learning in higher education (HE). Emerging technologies bring opportunities to reconsider teaching and learning. New ideas and concepts

Create Your Plate

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Full Text Available ... Diabetes Meal Plans Create Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday Meal Planning ... Planning Meals Diabetes Meal Plans and a Healthy Diet Create Your Plate Meal Planning for Vegetarian Diets ...

A Qualitative Study of Technology-Based Training in Organizations that Hire Agriculture and Life Sciences Students

Science.gov (United States)

Bedgood, Leslie; Murphrey, Theresa Pesl; Dooley, Kim E.

2008-01-01