WorldWideScience

Sample records for system formidable challenges

  1. A formidable synthetic challenge

    Indian Academy of Sciences (India)

    Isolation and characterization of maoecrystal V, a C19 terpenoid, having potent and selective cytotoxicity towards HeLa cells was recently reported. Unusually complex pentacyclic molecular structure, presence of spirofused rings and several stereogenic centres posed a great synthetic challenge. In this short review, efforts ...

  2. Family Planning in the Democratic Republic of the Congo: Encouraging Momentum, Formidable Challenges.

    Science.gov (United States)

    Kwete, Dieudonné; Binanga, Arsene; Mukaba, Thibaut; Nemuandjare, Théophile; Mbadu, Muanda Fidele; Kyungu, Marie-Thérèse; Sutton, Perri; Bertrand, Jane T

    2018-03-21

    Momentum for family planning in the Democratic Republic of the Congo (DRC) is evident in multiple ways: strong political will, increasing donor support, a growing number of implementing organizations, innovative family planning programming, and a cohesive family planning stakeholder group. Between 2013 and 2017, the modern contraceptive prevalence rate (mCPR) in the capital city of Kinshasa increased from 18.5% to 26.7% among married women, but as of 2013-14, it was only 7.8% at the national level. The National Multisectoral Strategic Plan for Family Planning: 2014-2020 calls for achieving an mCPR of 19.0% by 2020, an ambitious goal in light of formidable challenges to family planning in the DRC. Of the 16,465 health facilities reporting to the national health information system in 2017, only 40% offer family planning services. Key challenges include uncertainty over the political situation, difficulties of ensuring access to family planning services in a vast country with a weak transportation infrastructure, funding shortfalls for procuring adequate quantities of contraceptives, weak contraceptive logistics and supply chain management, strong cultural norms that favor large families, and low capacity of the population to pay for contraceptive services. This article describes promising initiatives designed to address these barriers, consistent with the World Health Organization's framework for health systems strengthening. For example, the national family planning coordinating mechanism is being replicated at the provincial level to oversee the expansion of family planning service delivery. Promising initiatives are being implemented to improve the supply and quality of services and generate demand for family planning, including social marketing of subsidized contraceptives at both traditional and non-traditional channels and strengthening of services in military health facilities. To expand contraceptive access, family planning is being institutionalized in

  3. On avoiding dangerous anthropogenic interference with the climate system: formidable challenges ahead.

    Science.gov (United States)

    Ramanathan, V; Feng, Y

    2008-09-23

    The observed increase in the concentration of greenhouse gases (GHGs) since the preindustrial era has most likely committed the world to a warming of 2.4 degrees C (1.4 degrees C to 4.3 degrees C) above the preindustrial surface temperatures. The committed warming is inferred from the most recent Intergovernmental Panel on Climate Change (IPCC) estimates of the greenhouse forcing and climate sensitivity. The estimated warming of 2.4 degrees C is the equilibrium warming above preindustrial temperatures that the world will observe even if GHG concentrations are held fixed at their 2005 concentration levels but without any other anthropogenic forcing such as the cooling effect of aerosols. The range of 1.4 degrees C to 4.3 degrees C in the committed warming overlaps and surpasses the currently perceived threshold range of 1 degrees C to 3 degrees C for dangerous anthropogenic interference with many of the climate-tipping elements such as the summer arctic sea ice, Himalayan-Tibetan glaciers, and the Greenland Ice Sheet. IPCC models suggest that approximately 25% (0.6 degrees C) of the committed warming has been realized as of now. About 90% or more of the rest of the committed warming of 1.6 degrees C will unfold during the 21st century, determined by the rate of the unmasking of the aerosol cooling effect by air pollution abatement laws and by the rate of release of the GHGs-forcing stored in the oceans. The accompanying sea-level rise can continue for more than several centuries. Lastly, even the most aggressive CO(2) mitigation steps as envisioned now can only limit further additions to the committed warming, but not reduce the already committed GHGs warming of 2.4 degrees C.

  4. On avoiding dangerous anthropogenic interference with the climate system: Formidable challenges ahead

    Science.gov (United States)

    Ramanathan, V.; Feng, Y.

    2008-01-01

    The observed increase in the concentration of greenhouse gases (GHGs) since the preindustrial era has most likely committed the world to a warming of 2.4°C (1.4°C to 4.3°C) above the preindustrial surface temperatures. The committed warming is inferred from the most recent Intergovernmental Panel on Climate Change (IPCC) estimates of the greenhouse forcing and climate sensitivity. The estimated warming of 2.4°C is the equilibrium warming above preindustrial temperatures that the world will observe even if GHG concentrations are held fixed at their 2005 concentration levels but without any other anthropogenic forcing such as the cooling effect of aerosols. The range of 1.4°C to 4.3°C in the committed warming overlaps and surpasses the currently perceived threshold range of 1°C to 3°C for dangerous anthropogenic interference with many of the climate-tipping elements such as the summer arctic sea ice, Himalayan–Tibetan glaciers, and the Greenland Ice Sheet. IPCC models suggest that ≈25% (0.6°C) of the committed warming has been realized as of now. About 90% or more of the rest of the committed warming of 1.6°C will unfold during the 21st century, determined by the rate of the unmasking of the aerosol cooling effect by air pollution abatement laws and by the rate of release of the GHGs-forcing stored in the oceans. The accompanying sea-level rise can continue for more than several centuries. Lastly, even the most aggressive CO2 mitigation steps as envisioned now can only limit further additions to the committed warming, but not reduce the already committed GHGs warming of 2.4°C. PMID:18799733

  5. Maoecrystal V: A formidable synthetic challenge

    Indian Academy of Sciences (India)

    Magdziak D, Meek S J and Pettus T R R 2004 Chem. Rev. 104 1383. 30. Roche S P and Porco Jr J A 2011 Angew. Chem. Int. Ed. 50 4068. 31. (a) Singh V 1999 Acc. Chem. Res. 32 324; (b) Singh V,. Praveena G D, Karki K and Mobin S M 2007 J. Org. Chem. 72 2058; (c) Singh V, Sahu P K, Sahu B C and. Mobin S M 2009 ...

  6. Maoecrystal V: A formidable synthetic challenge

    Indian Academy of Sciences (India)

    Maoecrystal V; synthesis; Diels–Alder reaction; dearomatization. 1. Introduction. There is continuing search for ... of ailments, is known to be a rich source of biologi- cally active diterpenoids.5 Maoecrystal V (figure 1) ... ever, only two groups have succeeded in the synthesis of maoecrystal V since its isolation a decade ago.

  7. Maoecrystal V: A formidable synthetic challenge

    Indian Academy of Sciences (India)

    Nature continues to be a rich source of bio-active compounds that often provide the lead for drug development. Isolation and characterization of maoecrystal V, a C19 terpenoid, having potent and selective cytotoxicity towards HeLa cells was recently reported. Unusually complex pentacyclic molecular structure, presence of ...

  8. Weapons make the man (larger): formidability is represented as size and strength in humans.

    Science.gov (United States)

    Fessler, Daniel M T; Holbrook, Colin; Snyder, Jeffrey K

    2012-01-01

    In order to determine how to act in situations of potential agonistic conflict, individuals must assess multiple features of a prospective foe that contribute to the foe's resource-holding potential, or formidability. Across diverse species, physical size and strength are key determinants of formidability, and the same is often true for humans. However, in many species, formidability is also influenced by other factors, such as sex, coalitional size, and, in humans, access to weaponry. Decision-making involving assessments of multiple features is enhanced by the use of a single summary variable that encapsulates the contributions of these features. Given both a) the phylogenetic antiquity of the importance of size and strength as determinants of formidability, and b) redundant experiences during development that underscore the contributions of size and strength to formidability, we hypothesize that size and strength constitute the conceptual dimensions of a representation used to summarize multiple diverse determinants of a prospective foe's formidability. Here, we test this hypothesis in humans by examining the effects of a potential foe's access to weaponry on estimations of that individual's size and strength. We demonstrate that knowing that an individual possesses a gun or a large kitchen knife leads observers to conceptualize him as taller, and generally larger and more muscular, than individuals who possess only tools or similarly mundane objects. We also document that such patterns are not explicable in terms of any actual correlation between gun ownership and physical size, nor can they be explained in terms of cultural schemas or other background knowledge linking particular objects to individuals of particular size and strength. These findings pave the way for a fuller understanding of the evolution of the cognitive systems whereby humans--and likely many other social vertebrates--navigate social hierarchies.

  9. Weapons make the man (larger: formidability is represented as size and strength in humans.

    Directory of Open Access Journals (Sweden)

    Daniel M T Fessler

    Full Text Available In order to determine how to act in situations of potential agonistic conflict, individuals must assess multiple features of a prospective foe that contribute to the foe's resource-holding potential, or formidability. Across diverse species, physical size and strength are key determinants of formidability, and the same is often true for humans. However, in many species, formidability is also influenced by other factors, such as sex, coalitional size, and, in humans, access to weaponry. Decision-making involving assessments of multiple features is enhanced by the use of a single summary variable that encapsulates the contributions of these features. Given both a the phylogenetic antiquity of the importance of size and strength as determinants of formidability, and b redundant experiences during development that underscore the contributions of size and strength to formidability, we hypothesize that size and strength constitute the conceptual dimensions of a representation used to summarize multiple diverse determinants of a prospective foe's formidability. Here, we test this hypothesis in humans by examining the effects of a potential foe's access to weaponry on estimations of that individual's size and strength. We demonstrate that knowing that an individual possesses a gun or a large kitchen knife leads observers to conceptualize him as taller, and generally larger and more muscular, than individuals who possess only tools or similarly mundane objects. We also document that such patterns are not explicable in terms of any actual correlation between gun ownership and physical size, nor can they be explained in terms of cultural schemas or other background knowledge linking particular objects to individuals of particular size and strength. These findings pave the way for a fuller understanding of the evolution of the cognitive systems whereby humans--and likely many other social vertebrates--navigate social hierarchies.

  10. Airway management in Escobar syndrome: A formidable challenge

    Directory of Open Access Journals (Sweden)

    Shaji Mathew

    2013-01-01

    Full Text Available Escobar syndrome is a rare autosomal recessive disorder characterized by flexion joint and digit contractures, skin webbing, cleft palate, deformity of spine and cervical spine fusion. Associated difficult airway is mainly due to micrognathia, retrognathia, webbing of neck and limitation of the mouth opening and neck extension. We report a case of a 1 year old child with Escobar syndrome posted for bilateral hamstrings to quadriceps transfer. The child had adequate mouth opening with no evidence of cervical spine fusion, yet we faced difficulty in intubation which was ultimately overcome by securing a proseal laryngeal mask airway (PLMA and then by intubating with an endotracheal tube railroaded over a paediatric fibreoptic bronchoscope passed through the lumen of a PLMA.

  11. The role of physical formidability in human social status allocation.

    Science.gov (United States)

    Lukaszewski, Aaron W; Simmons, Zachary L; Anderson, Cameron; Roney, James R

    2016-03-01

    Why are physically formidable men willingly allocated higher social status by others in cooperative groups? Ancestrally, physically formidable males would have been differentially equipped to generate benefits for groups by providing leadership services of within-group enforcement (e.g., implementing punishment of free riders) and between-group representation (e.g., negotiating with other coalitions). Therefore, we hypothesize that adaptations for social status allocation are designed to interpret men's physical formidability as a cue to these leadership abilities, and to allocate greater status to formidable men on this basis. These hypotheses were supported in 4 empirical studies wherein young adults rated standardized photos of subjects (targets) who were described as being part of a white-collar business consultancy. In Studies 1 and 2, male targets' physical strength positively predicted ratings of their projected status within the organization, and this effect was mediated by perceptions that stronger men possessed greater leadership abilities of within-group enforcement and between-group representation. Moreover, (a) these same patterns held whether status was conceptualized as overall ascendancy, prestige-based status, or dominance-based status, and (b) strong men who were perceived as aggressively self-interested were not allocated greater status. Finally, 2 experiments established the causality of physical formidability's effects on status-related perceptions by manipulating targets' relative strength (Study 3) and height (Study 4). In interpreting our findings, we argue that adaptations for formidability-based status allocation may have facilitated the evolution of group cooperation in humans and other primates. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  12. Grand Challenges facing Storage Systems

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    In this talk, we will discuss the future of storage systems. In particular, we will focus on several big challenges which we are facing in storage, such as being able to build, manage and backup really massive storage systems, being able to find information of interest, being able to do long-term archival of data, and so on. We also present ideas and research being done to address these challenges, and provide a perspective on how we expect these challenges to be resolved as we go forward.

  13. Ecological Challenges for Closed Systems

    Science.gov (United States)

    Nelson, Mark; Dempster, William; Allen, John P.

    2012-07-01

    Closed ecological systems are desirable for a number of purposes. In space life support systems, material closure allows precious life-supporting resources to be kept inside and recycled. Closure in small biospheric systems facilitates detailed measurement of global ecological processes and biogeochemical cycles. Closed testbeds facilitate research topics which require isolation from the outside (e.g. genetically modified organisms; radioisotopes) so their ecological interactions and fluxes can be studied separate from interactions with the outside environment. But to achieve and maintain closure entails solving complex ecological challenges. These challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro- and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet and recycling nutrients and maintaining soil fertility, the sustaining of healthy air and water and preventing the loss of crucial elements from active circulation. In biospheric facilities the challenge is also to produce analogues to natural biomes and ecosystems, studying processes of self-organization and adaptation in systems that allow specification or determination of state variables and cycles which may be followed through all interactions from atmosphere to soils. Other challenges include the dynamics and genetics of small populations, the psychological challenges for small isolated human groups and measures and options which may be necessary to ensure long-term operation of closed ecological systems.

  14. Embedded Systems Design: Optimization Challenges

    DEFF Research Database (Denmark)

    Pop, Paul

    2005-01-01

    -to-market, and reduce development and manufacturing costs. In this paper, the author introduces several embedded systems design problems, and shows how they can be formulated as optimization problems. Solving such challenging design optimization problems are the key to the success of the embedded systems design...... of designing such systems is becoming increasingly important and difficult at the same time. New automated design optimization techniques are needed, which are able to: successfully manage the complexity of embedded systems, meet the constraints imposed by the application domain, shorten the time...

  15. To Defer or To Stand Up? How Offender Formidability Affects Third Party Moral Outrage

    DEFF Research Database (Denmark)

    Jensen, Niels Holm; Petersen, Michael Bang

    2011-01-01

    , therefore, be sensitive to these cost- benefit trade-offs. To test this argument, participants read scenarios containing exploitative acts (trivial vs. serious) and were presented with head-shot photos of the apparent exploiters (formidable vs. non-formidable). As predicted, results showed that, compared...

  16. Challenges in Designing Mechatronic Systems

    DEFF Research Database (Denmark)

    Torry-Smith, Jonas; Qamar, Ahsan; Achiche, Sofiane

    2013-01-01

    Development of mechatronic products is traditionally carried out by several design experts from different design domains. Performing development of mechatronic products is thus greatly challenging. In order to tackle this, the critical challenges in mechatronics have to be well understood and well...

  17. Size, skills, and suffrage: Motivated distortions in perceived formidability of political leaders.

    Directory of Open Access Journals (Sweden)

    Jill E P Knapen

    Full Text Available Research shows that perception of physical size and status are positively associated. The current study was developed to replicate and extend earlier research on height perceptions of political leaders, indicating that supporters perceive their leaders as taller than non-supporters do, and winners are perceived as taller after the elections, while losers are perceived as shorter after the elections (winner/loser effects. Individuals use greater height and strength as indications of greater physical formidability. We hypothesized that in-group leaders' height and strength, but not weight, would be overestimated more compared to out-group leaders', and that this status-size association is not only driven by dominance, but also by prestige. We also tested whether previously found gender effects in estimates were due to using one's own height as an anchor, and we used an improved methodological approach by relying on multiple measurements of physical formidability and a within-subject design for testing winner/loser effects. The results of a two-part longitudinal study (self-selected sample via voting advice website; NWave1 = 2,011; NWave2 = 322 suggest that estimated physical formidability of political leaders is affected by motivated perception, as prestige was positively associated with estimated formidability, and in-group leaders were estimated more formidable than out-group leaders. We conclude that distortions in judged formidability related to social status are the result of motivated social perception in order to promote group functioning and leadership. Although we did not replicate a winner-effect (greater estimations of formidability after winning the elections, we did find some evidence for a loser-effect. Earlier suggestions that men make larger estimations than women because of their own larger body size are not supported. Implications for theory and future research are discussed.

  18. Size, skills, and suffrage: Motivated distortions in perceived formidability of political leaders.

    Science.gov (United States)

    Knapen, Jill E P; Blaker, Nancy M; Pollet, Thomas V

    2017-01-01

    Research shows that perception of physical size and status are positively associated. The current study was developed to replicate and extend earlier research on height perceptions of political leaders, indicating that supporters perceive their leaders as taller than non-supporters do, and winners are perceived as taller after the elections, while losers are perceived as shorter after the elections (winner/loser effects). Individuals use greater height and strength as indications of greater physical formidability. We hypothesized that in-group leaders' height and strength, but not weight, would be overestimated more compared to out-group leaders', and that this status-size association is not only driven by dominance, but also by prestige. We also tested whether previously found gender effects in estimates were due to using one's own height as an anchor, and we used an improved methodological approach by relying on multiple measurements of physical formidability and a within-subject design for testing winner/loser effects. The results of a two-part longitudinal study (self-selected sample via voting advice website; NWave1 = 2,011; NWave2 = 322) suggest that estimated physical formidability of political leaders is affected by motivated perception, as prestige was positively associated with estimated formidability, and in-group leaders were estimated more formidable than out-group leaders. We conclude that distortions in judged formidability related to social status are the result of motivated social perception in order to promote group functioning and leadership. Although we did not replicate a winner-effect (greater estimations of formidability after winning the elections), we did find some evidence for a loser-effect. Earlier suggestions that men make larger estimations than women because of their own larger body size are not supported. Implications for theory and future research are discussed.

  19. Challenges in Business System Integration

    NARCIS (Netherlands)

    Hvolby, H.H.; Trienekens, J.H.

    2010-01-01

    Four main frameworks for intercompany relationships (SCOR, CPFR, ISA95 and OAG) are discussed and compared. The link between the frameworks and different supply chain integration applications such as ERP, CRM and VMI are pictured. Finally the state-of-the-art, future state and challenges of the

  20. With God on our side: Religious primes reduce the envisioned physical formidability of a menacing adversary.

    Science.gov (United States)

    Holbrook, Colin; Fessler, Daniel M T; Pollack, Jeremy

    2016-01-01

    The imagined support of benevolent supernatural agents attenuates anxiety and risk perception. Here, we extend these findings to judgments of the threat posed by a potentially violent adversary. Conceptual representations of bodily size and strength summarize factors that determine the relative threat posed by foes. The proximity of allies moderates the envisioned physical formidability of adversaries, suggesting that cues of access to supernatural allies will reduce the envisioned physical formidability of a threatening target. Across two studies, subtle cues of both supernatural and earthly social support reduced the envisioned physical formidability of a violent criminal. These manipulations had no effect on the perceived likelihood of encountering non-conflictual physical danger, raising the possibility that imagined supernatural support leads participants to view themselves not as shielded from encountering perilous situations, but as protected should perils arise. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Challenges for Nordic VET-systems

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    2015-01-01

    . This situation calls for new solutions to tackle the challenge of double qualifications. The question, which I will examine in this chapter, is how the Nordic VET-systems have handled this challenge in different ways and what these systems can learn from Switzerland, which is often highlighted as a model...

  2. Embedded Systems Design: Optimization Challenges

    DEFF Research Database (Denmark)

    Pop, Paul

    2005-01-01

    Summary form only given. Embedded systems are everywhere: from alarm clocks to PDAs, from mobile phones to cars, almost all the devices we use are controlled by embedded systems. Over 99% of the microprocessors produced today are used in embedded systems, and recently the number of embedded systems...... in use has become larger than the number of humans on the planet. The complexity of embedded systems is growing at a very high pace and the constraints in terms of functionality, performance, low energy consumption, reliability, cost and time-to-market are getting tighter. Therefore, the task...... of designing such systems is becoming increasingly important and difficult at the same time. New automated design optimization techniques are needed, which are able to: successfully manage the complexity of embedded systems, meet the constraints imposed by the application domain, shorten the time...

  3. Assessing Causal Pathways between Physical Formidability and Aggression in Human Males

    DEFF Research Database (Denmark)

    Petersen, Michael Bang; Dawes, Christopher T.

    2017-01-01

    Studies suggest the existence of an association between the physical formidability of human males and their level of aggression. This association is theoretically predictable from animal models of conflict behavior but could emerge from multiple different causal pathways. Previous studies have...

  4. Providing Equal Access to Education--A Formidable Challenge for China

    Science.gov (United States)

    Jones, Narelle; Maxwell, Bev; Palmer, Bill

    1996-01-01

    The People's Republic of China has seen a dramatic growth in its economy in recent years. It has a rapidly increasing population of approximately 1.2 billion people, though the population is still largely rural with about 80% of people living outside urban areas. China in its Education Law (1995) restated its commitment to universal education. In…

  5. Solitary tubercular caecal ulcer causing massive lower gastrointestinal bleed: a formidable diagnostic challenge.

    Science.gov (United States)

    Ram, Duvuru; Karthikeyan, Vilvapathy Senguttuvan; Sistla, Sarath Chandra; Ali, Sheik Manwar

    2014-03-06

    Gastrointestinal (GI) haemorrhage is a common surgical emergency accounting for approximately 1% of acute hospital admissions. Lower GI bleed is less common and less severe than upper GI bleed and is usually caused by diverticulosis, neoplasms, angiodysplasia and inflammatory bowel disease. A 51-year-old man presented with massive lower GI bleed. He had no history of tuberculosis. He underwent colonoscopy and an isolated caecal ulcer was noted. Segmental ileocaecal resection was performed and no specific cause was identifiable on histopathology. PCR was performed on this specimen and it was positive for Mycobacterium tuberculosis. This case reports the unusual presentation of tuberculosis as solitary caecal ulcer with massive lower GI bleed and highlights the role of PCR as an adjuvant diagnostic tool for its diagnosis when characteristic histopathological findings are absent.

  6. Life Support Systems Microbial Challenges

    Science.gov (United States)

    Roman, Monsi C.

    2010-01-01

    Many microbiological studies were performed during the development of the Space Station Water Recovery and Management System from1990-2009. Studies include assessments of: (1) bulk phase (planktonic) microbial population (2) biofilms, (3) microbially influenced corrosion (4) biofouling treatments. This slide presentation summarizes the studies performed to assess the bulk phase microbial community during the Space Station Water Recovery Tests (WRT) from 1990 to 1998. This report provides an overview of some of the microbiological analyses performed during the Space Station WRT program. These tests not only integrated several technologies with the goal of producing water that met NASA s potable water specifications, but also integrated humans, and therefore human flora into the protocols. At the time these tests were performed, not much was known (or published) about the microbial composition of these types of wastewater. It is important to note that design changes to the WRS have been implemented over the years and results discussed in this report might be directly related to test configurations that were not chosen for the final flight configuration. Results microbiological analyses performed Conclusion from the during the WRT showed that it was possible to recycle water from different sources, including urine, and produce water that can exceed the quality of municipally produced water.

  7. Key ecological challenges for closed systems facilities

    Science.gov (United States)

    Nelson, Mark; Dempster, William F.; Allen, John P.

    2013-07-01

    Closed ecological systems are desirable for a number of purposes. In space life support systems, material closure allows precious life-supporting resources to be kept inside and recycled. Closure in small biospheric systems facilitates detailed measurement of global ecological processes and biogeochemical cycles. Closed testbeds facilitate research topics which require isolation from the outside (e.g. genetically modified organisms; radioisotopes) so their ecological interactions and fluxes can be studied separate from interactions with the outside environment. But to achieve and maintain closure entails solving complex ecological challenges. These challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro- and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet, recycling nutrients and maintaining soil fertility, the maintenance of healthy air and water and preventing the loss of critical elements from active circulation. In biospheric facilities, the challenge is also to produce analogues to natural biomes and ecosystems, studying processes of self-organization and adaptation in systems that allow specification or determination of state variables and cycles which may be followed through all interactions from atmosphere to soils. Other challenges include the dynamics and genetics of small populations, the psychological challenges for small isolated human groups and backup technologies and strategic options which may be necessary to ensure long-term operation of closed ecological systems.

  8. THE QATAR HEALTH SYSTEM: CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Shaher ALSHAMARI

    2017-06-01

    Full Text Available Qatar’s healthcare system is comparatively new and has experienced noteworthy developments over its brief history. In this paper, our aim is to look at the unique challenges this small nation has faced in building that system. This paper will describe the accomplishments of Qatar’s medical authorities and the challenges they faced. It will also compare public and private healthcare providers. Today, the government of Qatar has financed all the health care for this rapidly-developing, multicultural nation, but it is now planning to introduce medical insurance. This report of its experience will benefit other nations wanting to develop their own healthcare systems.

  9. Applying Systems Engineering on Energy Challenges

    NARCIS (Netherlands)

    Safi, J.; Muller, G.; Bonnema, Gerrit Maarten

    2012-01-01

    Systems engineering is a discipline with methods and techniques to address complex problems. We want to study how Systems Engineering methods can help to address today's grand challenges, such as the energy problem. The first step is problem definition which aims at articulating the problem in its

  10. Control challenges in domestic heating systems

    DEFF Research Database (Denmark)

    Thybo, Honglian; Larsen, Lars F. S.; Weitzmann, Peter

    2007-01-01

    The objective of this paper is to analyze domestic heating applications and identify unfavorable building constructions and control challenges to be addressed by high performance heating control systems. Heating of domestic houses use a large amount of the total energy consumption in Scandinavia....... Hence the potential of reducing energy consumption by applying high performance control is vast. Indoor climate issues are becoming more in focus, which also leads to a demand for high performance heating systems. The paper presents an analysis of how the building elements of today's domestic houses...... with water based floor heating affect the control challenge. The analysis is documented with simulation results....

  11. Employability: Challenges for Education and Training Systems

    Science.gov (United States)

    Perez, Elena Arjona; Garrouste, Christelle; Kozovska, Kornelia

    The recent crisis has taken its toll in terms of unemployment, especially among young people. This has revived the debate on the contribution of Education and Training (E&T) systems to the employability of young graduates. At European policy level, there is a growing interest in creating incentives for reforming E&T systems so as to make them more responsive to future labour market needs and short term adverse labour market conditions. One of the main challenges is finding valid measures for evaluating the contribution of E&T systems to employability, taking into account their diversity within the European Union. This paper presents an operational framework of analysis for employability and discusses some of the most important challenges related to the multidimensional nature of the employability concept, the lack of data for cross-country comparison and the difficulty of disentangling the role of education and training systems from other factors in evaluating labour market outcomes.

  12. Requirements for guidelines systems: implementation challenges and lessons from existing software-engineering efforts.

    Science.gov (United States)

    Shah, Hemant; Allard, Raymond D; Enberg, Robert; Krishnan, Ganesh; Williams, Patricia; Nadkarni, Prakash M

    2012-03-09

    A large body of work in the clinical guidelines field has identified requirements for guideline systems, but there are formidable challenges in translating such requirements into production-quality systems that can be used in routine patient care. Detailed analysis of requirements from an implementation perspective can be useful in helping define sub-requirements to the point where they are implementable. Further, additional requirements emerge as a result of such analysis. During such an analysis, study of examples of existing, software-engineering efforts in non-biomedical fields can provide useful signposts to the implementer of a clinical guideline system. In addition to requirements described by guideline-system authors, comparative reviews of such systems, and publications discussing information needs for guideline systems and clinical decision support systems in general, we have incorporated additional requirements related to production-system robustness and functionality from publications in the business workflow domain, in addition to drawing on our own experience in the development of the Proteus guideline system (http://proteme.org). The sub-requirements are discussed by conveniently grouping them into the categories used by the review of Isern and Moreno 2008. We cite previous work under each category and then provide sub-requirements under each category, and provide example of similar work in software-engineering efforts that have addressed a similar problem in a non-biomedical context. When analyzing requirements from the implementation viewpoint, knowledge of successes and failures in related software-engineering efforts can guide implementers in the choice of effective design and development strategies.

  13. Multi-scale biomedical systems: measurement challenges

    International Nuclear Information System (INIS)

    Summers, R

    2016-01-01

    Multi-scale biomedical systems are those that represent interactions in materials, sensors, and systems from a holistic perspective. It is possible to view such multi-scale activity using measurement of spatial scale or time scale, though in this paper only the former is considered. The biomedical application paradigm comprises interactions that range from quantum biological phenomena at scales of 10-12 for one individual to epidemiological studies of disease spread in populations that in a pandemic lead to measurement at a scale of 10+7. It is clear that there are measurement challenges at either end of this spatial scale, but those challenges that relate to the use of new technologies that deal with big data and health service delivery at the point of care are also considered. The measurement challenges lead to the use, in many cases, of model-based measurement and the adoption of virtual engineering. It is these measurement challenges that will be uncovered in this paper. (paper)

  14. Challenging problems and solutions in intelligent systems

    CERN Document Server

    Grzegorzewski, Przemysław; Kacprzyk, Janusz; Owsiński, Jan; Penczek, Wojciech; Zadrożny, Sławomir

    2016-01-01

    This volume presents recent research, challenging problems and solutions in Intelligent Systems– covering the following disciplines: artificial and computational intelligence, fuzzy logic and other non-classic logics, intelligent database systems, information retrieval, information fusion, intelligent search (engines), data mining, cluster analysis, unsupervised learning, machine learning, intelligent data analysis, (group) decision support systems, intelligent agents and multi-agent systems, knowledge-based systems, imprecision and uncertainty handling, electronic commerce, distributed systems, etc. The book defines a common ground for sometimes seemingly disparate problems and addresses them by using the paradigm of broadly perceived intelligent systems. It presents a broad panorama of a multitude of theoretical and practical problems which have been successfully dealt with using the paradigm of intelligent computing.

  15. Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases.

    Science.gov (United States)

    Baswan, Sudhir; Kasting, Gerald B; Li, S Kevin; Wickett, Randy; Adams, Brian; Eurich, Sean; Schamper, Ryan

    2017-05-01

    The topical treatment of nail fungal infections has been a focal point of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. A few of the parameters affecting the nail permeability and potential causes of the recurrence of fungal nail infection are also discussed. © 2017 Blackwell Verlag GmbH.

  16. Systems biology solutions for biochemical production challenges

    DEFF Research Database (Denmark)

    Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus

    2017-01-01

    characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity......There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics...

  17. Middleware Challenges for Cyber-Physical Systems

    DEFF Research Database (Denmark)

    Mohamed, Nader; Al-Jaroodi, Jameela; Lazarova-Molnar, Sanja

    2017-01-01

    to provide advanced monitoring and control mechanisms geared towards enhancing the targeted physical system or environment. These components function seamlessly to offer specific functionalities that help enhance human lives, physical system operations and environments. While CPS can offer many smart......Cyber-Physical Systems (CPS) are being developed to provide useful interactions between physical systems and environments and cyber world for a variety of applications. CPS are designed with a set of software and interconnected distributed hardware components that are linked with physical elements...... enhancements for improving physical processes, the development of such complex systems composed of many distributed and heterogeneous components is extremely difficult. This is due to the many communication, computing, and networking challenges. Using an appropriate middleware that provides a framework...

  18. Nuclear Hybrid Energy Systems: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    P. Sabharwall; S.B. Sitton; S.J. Yoon; C. Stoots

    2014-07-01

    With growing demand of energy and costs of the fossil fuels, coupled with the environmental concerns have resulted in an increased interest in alternative energy sources. Nuclear hybrid energy systems (NHES) are being considered which incorporates renewable energy sources such as solar and wind energy combined with nuclear reactor and energy storage to meet the peak hours demand imposed on the grid, along with providing process heat for other potential industrial applications. This concept could potentially satisfy various energy demands and improve reliability, robustness and resilience for the entire system as a whole, along with economic and net efficiency gains. This paper provides a brief understanding of potential NHES system and architecture along with the challenges

  19. Information systems in logistics - transition challenges

    Directory of Open Access Journals (Sweden)

    Nikolay Dragomirov

    2016-03-01

    Full Text Available The implementation of information systems in business organizations does not consist of just buying software products and installing them on the servers. Most of these systems are important for the development of the organizations concerned and in some cases are very expensive. Therefore, their success requires a properly managed process of implementation, which seeks a balance between the aims of the systems and the financial and technical capabilities of the organization. The implementation problem becomes greater when the emphasis is on the logistics function in the context of the supply chain management. Last, but not least, these initiatives are related to something much more challenging, namely the adoption of the new information system by the users, which involves a change of habits in the organization. It is no secret that a new system may be rejected by its users and this will make it useless. All this requires finding adequate solutions to analyze these problems and to ensure the effective use of information systems in logistics.

  20. Challenges for Rule Systems on the Web

    Science.gov (United States)

    Hu, Yuh-Jong; Yeh, Ching-Long; Laun, Wolfgang

    The RuleML Challenge started in 2007 with the objective of inspiring the issues of implementation for management, integration, interoperation and interchange of rules in an open distributed environment, such as the Web. Rules are usually classified as three types: deductive rules, normative rules, and reactive rules. The reactive rules are further classified as ECA rules and production rules. The study of combination rule and ontology is traced back to an earlier active rule system for relational and object-oriented (OO) databases. Recently, this issue has become one of the most important research problems in the Semantic Web. Once we consider a computer executable policy as a declarative set of rules and ontologies that guides the behavior of entities within a system, we have a flexible way to implement real world policies without rewriting the computer code, as we did before. Fortunately, we have de facto rule markup languages, such as RuleML or RIF to achieve the portability and interchange of rules for different rule systems. Otherwise, executing real-life rule-based applications on the Web is almost impossible. Several commercial or open source rule engines are available for the rule-based applications. However, we still need a standard rule language and benchmark for not only to compare the rule systems but also to measure the progress in the field. Finally, a number of real-life rule-based use cases will be investigated to demonstrate the applicability of current rule systems on the Web.

  1. A Framework for the Modelling of Biphasic Reacting Systems

    DEFF Research Database (Denmark)

    Anantpinijwatna, Amata; Sin, Gürkan; O’Connell, John P.

    2014-01-01

    Biphasic reacting systems have a broad application range from organic reactions in pharmaceutical and agro-bio industries to CO 2 capture. However, mathematical modelling of biphasic reacting systems is a formidable challenge due to many phenomena underlying the process such as chemical equilibrium...

  2. The challenge of greening energy systems

    International Nuclear Information System (INIS)

    Joseph, A.; Hughes, L.

    2006-01-01

    The current state of world energy supply and demand was examined along with future challenges facing population growth, economic growth, energy-demand growth, fossil energy supply, technology improvements, renewable energy solutions, and conservation measures. It was suggested that in order to implement cleaner and greener energy technology, it is important to understand the nature of global energy systems. The challenge of defining the related ideologies of green energy and sustainability was discussed. In this paper, green energy was defined as indicating environmental compatibility with little or no negative environmental impact. This differs from the concept of sustainability, which was defined as an action that can be repeated continuously without depleting or diminishing resources. In general, green energy options include most technologies that do not involve fossil fuels. However, this paper considered a spectrum of shades of green with some options being low-impact and cleaner, and others having high environmental impacts. As an example, the authors presented the ongoing debate over nuclear energy and hydro power. Although both energy sources can be sustainable over hundreds of years, they may or may not be environmentally compatible because they are often considered to have problematic attributes. Energy from renewable sources currently accounts for less than 20 per cent of world primary energy supply because price and implementation challenges in the renewables sector do not generally compare well to other energy sources. With high energy-demands beginning to strain finite fossil-energy supplies, the energy sector is now subject to more frequent disruptions and price fluctuations. Future growth from emerging economies will demand more energy and resources. This paper also emphasized that the proportion of green sources of energy has not increased substantially in the past 3 decades, and despite many technological advances, there continue to be significant

  3. Neural System Prediction and Identification Challenge

    Directory of Open Access Journals (Sweden)

    Ioannis eVlachos

    2013-12-01

    Full Text Available Can we infer the function of a biological neural network (BNN if we know the connectivity and activity of all its constituent neurons? This question is at the core of neuroscience and, accordingly, various methods have been developed to record the activity and connectivity of as many neurons as possible. Surprisingly, there is no theoretical or computational demonstration that neuronal activity and connectivity are indeed sufficient to infer the function of a BNN. Therefore, we pose the Neural Systems Identification and Prediction Challenge (nuSPIC. We provide the connectivity and activity of all neurons and invite participants (i to infer the functions implemented (hard-wired in spiking neural networks (SNNs by stimulating and recording the activity of neurons and, (ii to implement predefined mathematical/biological functions using SNNs. The nuSPICs can be accessed via a web-interface to the NEST simulator and the user is not required to know any specific programming language. Furthermore, the nuSPICs can be used as a teaching tool. Finally, nuSPICs use the crowd-sourcing model to address scientific issues. With this computational approach we aim to identify which functions can be inferred by systematic recordings of neuronal activity and connectivity. In addition, nuSPICs will help the design and application of new experimental paradigms based on the structure of the SNN and the presumed function which is to be discovered.

  4. Neural system prediction and identification challenge.

    Science.gov (United States)

    Vlachos, Ioannis; Zaytsev, Yury V; Spreizer, Sebastian; Aertsen, Ad; Kumar, Arvind

    2013-01-01

    Can we infer the function of a biological neural network (BNN) if we know the connectivity and activity of all its constituent neurons?This question is at the core of neuroscience and, accordingly, various methods have been developed to record the activity and connectivity of as many neurons as possible. Surprisingly, there is no theoretical or computational demonstration that neuronal activity and connectivity are indeed sufficient to infer the function of a BNN. Therefore, we pose the Neural Systems Identification and Prediction Challenge (nuSPIC). We provide the connectivity and activity of all neurons and invite participants (1) to infer the functions implemented (hard-wired) in spiking neural networks (SNNs) by stimulating and recording the activity of neurons and, (2) to implement predefined mathematical/biological functions using SNNs. The nuSPICs can be accessed via a web-interface to the NEST simulator and the user is not required to know any specific programming language. Furthermore, the nuSPICs can be used as a teaching tool. Finally, nuSPICs use the crowd-sourcing model to address scientific issues. With this computational approach we aim to identify which functions can be inferred by systematic recordings of neuronal activity and connectivity. In addition, nuSPICs will help the design and application of new experimental paradigms based on the structure of the SNN and the presumed function which is to be discovered.

  5. Safe vs. Fair: A Formidable Trade-off in Tackling Climate Change

    Directory of Open Access Journals (Sweden)

    Robert Socolow

    2012-02-01

    Full Text Available Global warming requires a response characterized by forward-looking management of atmospheric carbon and respect for ethical principles. Both safety and fairness must be pursued, and there are severe trade-offs as these are intertwined by the limited headroom for additional atmospheric CO2 emissions. This paper provides a simple numerical mapping at the aggregated level of developed vs. developing countries in which safety and fairness are formulated in terms of cumulative emissions and cumulative per capita emissions respectively. It becomes evident that safety and fairness cannot be achieved simultaneously for strict definitions of both. The paper further posits potential global trading in future cumulative emissions budgets in a world where financial transactions compensate for physical emissions: the safe vs. fair tradeoff is less severe but remains formidable. Finally, we explore very large deployment of engineered carbon sinks and show that roughly 1,000 Gt CO2 of cumulative negative emissions over the century are required to have a significant effect, a remarkable scale of deployment. We also identify the unexplored issue of how such sinks might be treated in sub-global carbon accounting.

  6. Orion Absolute Navigation System Progress and Challenges

    Science.gov (United States)

    Holt, Greg N.; D'Souza, Christopher

    2011-01-01

    The Orion spacecraft is being designed as NASA's next-generation exploration vehicle for crewed missions beyond Low-Earth Orbit. The navigation system for the Orion spacecraft is being designed in a Multi-Organizational Design Environment (MODE) team including contractor and NASA personnel. The system uses an Extended Kalman Filter to process measurements and determine the state. The design of the navigation system has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudorange and deltarange, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, pad alignment, cold start are discussed as are

  7. Decision-Making Amplification under Uncertainty: An Exploratory Study of Behavioral Similarity and Intelligent Decision Support Systems

    Science.gov (United States)

    Campbell, Merle Wayne

    2013-01-01

    Intelligent decision systems have the potential to support and greatly amplify human decision-making across a number of industries and domains. However, despite the rapid improvement in the underlying capabilities of these "intelligent" systems, increasing their acceptance as decision aids in industry has remained a formidable challenge.…

  8. Power system dynamics: same phenomena; new challenges

    Energy Technology Data Exchange (ETDEWEB)

    Mansour, Yakout; Vaahedi, Ebraim; Xu, Wilsun; Chang, Allen [British Columbia Hydro, Vancouver, BC (Canada). Regional System Planning

    1994-12-31

    This paper presents a summary of how a utility met some challenges recently in two areas: transient angular stability and voltage stability. The paper also includes a view of what is evolving in these two areas. (author) 7 refs., 11 figs., 1 tab.

  9. A systems approach for management of pests and pathogens of nursery crops

    Science.gov (United States)

    Jennifer L. Parke; Niklaus J. Grünwald

    2012-01-01

    Horticultural nurseries are heterogeneous and spatially complex agricultural systems, which present formidable challenges to management of diseases and pests. Moreover, nursery plants shipped interstate and internationally can serve as important vectors for pathogens and pests that threaten both agriculture and forestry. Current regulatory strategies to prevent this...

  10. Measuring Systems Interoperability: Challenges and Opportunities

    National Research Council Canada - National Science Library

    Kasunic, Mark; Anderson, William

    2004-01-01

    Interoperability is the ability of systems, units, or forces to provide services to and accept services from other systems, units, or forces and to use the services exchanged to enable them to operate...

  11. Challenges in implementing electronic hand hygiene monitoring systems.

    Science.gov (United States)

    Conway, Laurie J

    2016-05-02

    Electronic hand hygiene (HH) monitoring systems offer the exciting prospect of a more precise, less biased measure of HH performance than direct observation. However, electronic systems are challenging to implement. Selecting a system that minimizes disruption to the physical infrastructure and to clinician workflow, and that fits with the organization's culture and budget, is challenging. Getting front-line workers' buy-in and addressing concerns about the accuracy of the system and how the data will be used are also difficult challenges. Finally, ensuring information from the system reaches front-line workers and is used by them to improve HH practice is a complex challenge. We describe these challenges in detail and suggests ways to overcome them. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  12. Challenges of communication system during emergency disaster ...

    African Journals Online (AJOL)

    The purpose of this review is to provide the overview of available systems and potential future systems for communication during disaster in Malaysia. Electronic searches in major subject loci databases such as MEDLINE (via PUBMED), Ovid, Science Direct, Scopus, IEEE Xplore digital library and Springer are used in ...

  13. Challenges of communication system during emergency disaster ...

    African Journals Online (AJOL)

    pc

    2017-10-05

    Oct 5, 2017 ... ABSTRACT. The purpose of this review is to provide the overview of available systems and potential future systems for communication during disaster in Malaysia. Electronic searches in major subject loci databases such as MEDLINE (via PUBMED), Ovid, Science Direct, Scopus,. IEEE Xplore digital library ...

  14. Plant systems biology: insights, advances and challenges.

    Science.gov (United States)

    Sheth, Bhavisha P; Thaker, Vrinda S

    2014-07-01

    Plants dwelling at the base of biological food chain are of fundamental significance in providing solutions to some of the most daunting ecological and environmental problems faced by our planet. The reductionist views of molecular biology provide only a partial understanding to the phenotypic knowledge of plants. Systems biology offers a comprehensive view of plant systems, by employing a holistic approach integrating the molecular data at various hierarchical levels. In this review, we discuss the basics of systems biology including the various 'omics' approaches and their integration, the modeling aspects and the tools needed for the plant systems research. A particular emphasis is given to the recent analytical advances, updated published examples of plant systems biology studies and the future trends.

  15. Lifesaving emergency obstetric services are inadequate in south-west Ethiopia: a formidable challenge to reducing maternal mortality in Ethiopia

    Science.gov (United States)

    2013-01-01

    Background Most maternal deaths take place during labour and within a few weeks after delivery. The availability and utilization of emergency obstetric care facilities is a key factor in reducing maternal mortality; however, there is limited evidence about how these institutions perform and how many people use emergency obstetric care facilities in rural Ethiopia. We aimed to assess the availability, quality, and utilization of emergency obstetric care services in the Gamo Gofa Zone of south-west Ethiopia. Methods We conducted a retrospective review of three hospitals and 63 health centres in Gamo Gofa. Using a retrospective review, we recorded obstetric services, documents, cards, and registration books of mothers treated and served in the Gamo Gofa Zone health facilities between July 2009 and June 2010. Results There were three basic and two comprehensive emergency obstetric care qualifying facilities for the 1,740,885 people living in Gamo Gofa. The proportion of births attended by skilled attendants in the health facilities was 6.6% of expected births, though the variation was large. Districts with a higher proportion of midwives per capita, hospitals and health centres capable of doing emergency caesarean sections had higher institutional delivery rates. There were 521 caesarean sections (0.8% of 64,413 expected deliveries and 12.3% of 4,231 facility deliveries). We recorded 79 (1.9%) maternal deaths out of 4,231 deliveries and pregnancy-related admissions at institutions, most often because of post-partum haemorrhage (42%), obstructed labour (15%) and puerperal sepsis (15%). Remote districts far from the capital of the Zone had a lower proportion of institutional deliveries (4% of deliveries, much higher than the average 1.9%). Conclusion Based on a population of 1.7 million people, there should be 14 basic and four comprehensive emergency obstetric care (EmOC) facilities in the Zone. Our study found that only three basic and two comprehensive EmOC service qualifying facilities serve this large population which is below the UN’s minimum recommendation. The utilization of the existing facilities for delivery was also low, which is clearly inadequate to reduce maternal deaths to the MDG target. PMID:24180672

  16. Trauma Systems: Origins, Evolution, and Current Challenges.

    Science.gov (United States)

    Pigneri, Danielle A; Beldowicz, Brian; Jurkovich, Gregory J

    2017-10-01

    Trauma is the leading cause of death among patients 46 years or younger, and having a system in place for the care of the injured is of paramount importance to the health of a community. The growth and development of civilian trauma systems has not been an easy process. The concept of regionalized health care that the trauma system models has been emulated by other specialized and time-sensitive areas of medicine, notably stroke and acute cardiac events. Continued process improvement, public education, support and involvement, a sound infrastructure, and integrated technology should remain our focus. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Homegarden systems: agricultural characteristics and challenges

    NARCIS (Netherlands)

    Hoogerbrugge, I.; Fresco, L.O.

    1993-01-01

    Many sources of informal, grey literature on agronomic aspects of homegardens are discussed with the aim to increase the understanding of current garden systems, of their evolution and of their potential for increasing food security

  18. Switched Systems and Motion Coordination: Combinatorial Challenges

    Science.gov (United States)

    Sadovsky, Alexander V.

    2016-01-01

    Problems of routing commercial air traffic in a terminal airspace encounter different constraints: separation assurance, aircraft performance limitations, regulations. The general setting of these problems is that of a switched control system. Such a system combines the differentiable motion of the aircraft with the combinatorial choices of choosing precedence when traffic routes merge and choosing branches when the routes diverge. This presentation gives an overview of the problem, the ATM context, related literature, and directions for future research.

  19. Challenges within ventilation systems during accident situations

    International Nuclear Information System (INIS)

    Neuberger, M.; Bletzer, P.; Fronhoefer, M.; Hardy, T.; Kuhn, W.; Ricketts, C.I.; Schmidmeier, K.H.

    1991-01-01

    To help estimate the mechanical loading at the service location two fluid dynamic codes were investigated. FLOWMASTER shows good results in generating the air-cleaning network and in calculating steady state conditions, but fails in calculating fluid dynamic transients. PROMO is very time consuming in generating the network, but one can obtain good results in calculating fluid dynamic transients. In addition to the challenges posed by elevated pressure, temperature, and air flow, the effects of shock waves, caused by explosions or hydrogen detonations must be considered. The problem of a 'shock-shock' in the flow after the diverging channel by high shock strengths were solved. In order to guarantee the safety margins of filter units during their entire service lives, filter performance needs to be verified under standardized test conditions that take into consideration the particularly adverse effects of filter exposure to super-saturated airflows and elevated differential pressure. The detail construction for a rig to type test filter units under fog conditions and increased pressure drop was finished, and the components of the test facility were chosen. (orig./DG)

  20. Past and future challenges in developing remote systems technology

    International Nuclear Information System (INIS)

    Ferguson, K.R.

    1978-01-01

    During the early development of remote systems for processing and examining fuel and materials from nuclear reactors, the facility designer and operator worked closely together to meet the challenges of this new field. Numerous challenges still face the nuclear remote systems engineer, e.g., the development of systems that reduce the exposure of workers, the need for advances in basic technology, and the development of cost-effective facilities. The solution to these and other challenges can be accelerated by an expanded program of information exchange, an aggressive development program, and improved project management procedures

  1. Modeling Biology Spanning Different Scales: An Open Challenge

    Directory of Open Access Journals (Sweden)

    Filippo Castiglione

    2014-01-01

    Full Text Available It is coming nowadays more clear that in order to obtain a unified description of the different mechanisms governing the behavior and causality relations among the various parts of a living system, the development of comprehensive computational and mathematical models at different space and time scales is required. This is one of the most formidable challenges of modern biology characterized by the availability of huge amount of high throughput measurements. In this paper we draw attention to the importance of multiscale modeling in the framework of studies of biological systems in general and of the immune system in particular.

  2. Challenges and Opportunities for the School System

    Science.gov (United States)

    Capogna, Stefania

    2015-01-01

    Educational agencies are going through a difficult transition, with important consequences in terms of de-legitimacy of the social mandate historically assigned to the school. The reason for this widespread unease can be traced to the fact that today we live in a complex system. This paper arises within this problematic framework with the intent…

  3. Healthcare information systems: the cognitive challenge.

    Science.gov (United States)

    Lintern, Gavan; Motavalli, Al

    2018-01-11

    Healthcare work is, to a considerable extent, cognitive. Subsequently, the analysis and the design of supporting technology must be sensitive to the cognitive and adaptive demands of the work and to the cognitive strategies employed by healthcare practitioners. Despite the vital role that cognition plays in healthcare work, current technocentric design approaches for healthcare technology do not account for it, failing to observe it during analysis and failing to develop support for it during design. By review and analysis of case studies, we show that healthcare systems developed without input from cognitive analysis and cognitive design fail to take account of important healthcare work processes and workflows. In contrast, systems developed with a cognitively-focused design strategy demonstrate how it is possible to introduce technology that supports and enhances the work strategies of those engaged in patient care. Significant problems emerge when technological support systems are developed without any serious and comprehensive attempt to understand the cognitive capabilities and skills deployed by those involved in patient care. In contrast, significant benefits accrue from taking full account of those cognitive capabilities and skills. Subsequently, the design and development of supporting technology must be sensitive to the cognitive demands of the work and the cognitive strategies employed by healthcare practitioners.

  4. Identity Management Mismatch Challenges in the Danish Municipality Administration System

    DEFF Research Database (Denmark)

    Andersen, Mads Schaarup; Christensen, Henrik Bærbak

    2010-01-01

    Integrating a COTS product in a company’s product portfolio is appealing from a business perspective but highly challenging from the perspective of the software architecture. In this paper we outline research challenges regarding authorization in the identity management part of the Danish...... municipality administration system, called Opus BRS, a system that integrates SAP, legacy mainframe systems, and other systems present in the individual municipalities. Each of these systems defines their own access control model and architecture, which leads to architectural mismatch that impacts security...

  5. Improving cold chain systems: Challenges and solutions.

    Science.gov (United States)

    Ashok, Ashvin; Brison, Michael; LeTallec, Yann

    2017-04-19

    While a number of new vaccines have been rolled out across the developing world (with more vaccines in the pipeline), cold chain systems are struggling to efficiently support national immunization programs in ensuring the availability of safe and potent vaccines. This article reflects on the Clinton Health Access Initiative, Inc. (CHAI) experience working since 2010 with national immunization programs and partners to improve vaccines cold chains in 10 countries-Ethiopia, Nigeria, Kenya, Malawi, Tanzania, Uganda, Cameroon, Mozambique, Lesotho and India - to identify the root causes and solutions for three common issues limiting cold chain performance. Key recommendations include: Collectively, the solutions detailed in this article chart a path to substantially improving the performance of the cold chain. Combined with an enabling global and in-country environment, it is possible to eliminate cold chain issues as a substantial barrier to effective and full immunization coverage over the next few years. Copyright © 2017. Published by Elsevier Ltd.

  6. Challenges in the optical system of GAIA

    Science.gov (United States)

    Le Poole, Rudolf S.

    2017-11-01

    The precision aimed at by ESA's Astrometry and Radial Velocity mission GAIA surpasses that of the successful HIPPARCOS mission by more than 2 orders of magnitude, while at the same time increasing the number of objects 10000 times. This overwhelming increase in performance (statistical weight increased by 8 orders of magnitude) is achieved by insisting on a full description in terms of photon shot noise as the fundamental limiting factor. Yet such measurements refer to wave front topography to be understood to the level of better than 100 pico meters, in an optical system a few meters across. Obviously such understanding relies heavily on the expected stability, and chromatic effects also are of dominant importance, requiring stellar spectral energy distributions to be determined. It is fascinating that the experience of HIPPARCOS can indeed generate sufficient confidence for these performance specifications to be within reach. Elaborating the design specifications and tolerances I hope to convince you of GAIA's imminent success.

  7. Grand societal challenges in information systems research and education

    CERN Document Server

    vom Brocke, Jan; Hofmann, Sara; Tumbas, Sanja

    2015-01-01

    This book examines how information systems research and education can play a major role in contributing to solutions to the Societal Grand Challenges formulated in "The Millennium Project" (millenium-project.org). Individual chapters focus on specific challenges, review existing approaches and contributions towards solutions in information systems research and outline a research agenda for these challenges. The topics considered in this volume range from climate change, population growth, global ICT availability, breakthroughs in science and technology and energy demand to ethical decision-making, policymaking, gender status and transnational crime prevention. It is the first book to present ideas on how the Information Systems discipline can contribute to the solution on this wide spectrum of grand societal challenges.

  8. Subclinical primary psychopathy, but not physical formidability or attractiveness, predicts conversational dominance in a zero-acquaintance situation.

    Directory of Open Access Journals (Sweden)

    Joseph H Manson

    Full Text Available The determinants of conversational dominance are not well understood. We used videotaped triadic interactions among unacquainted same-sex American college students to test predictions drawn from the theoretical distinction between dominance and prestige as modes of human status competition. Specifically, we investigated the effects of physical formidability, facial attractiveness, social status, and self-reported subclinical psychopathy on quantitative (proportion of words produced, participatory (interruptions produced and sustained, and sequential (topic control dominance. No measure of physical formidability or attractiveness was associated with any form of conversational dominance, suggesting that the characteristics of our study population or experimental frame may have moderated their role in dominance dynamics. Primary psychopathy was positively associated with quantitative dominance and (marginally overall triad talkativeness, and negatively associated (in men with affect word use, whereas secondary psychopathy was unrelated to conversational dominance. The two psychopathy factors had significant opposing effects on quantitative dominance in a multivariate model. These latter findings suggest that glibness in primary psychopathy may function to elicit exploitable information from others in a relationally mobile society.

  9. Intelligent Mobility Systems: Some Socio-technical Challenges and Opportunities

    Science.gov (United States)

    Büscher, Monika; Coulton, Paul; Efstratiou, Christos; Gellersen, Hans; Hemment, Drew; Mehmood, Rashid; Sangiorgi, Daniela

    Analysis of socio-technical challenges and opportunities around contemporary mobilities suggests new interpretations and visions for intelligent transport systems. Multiple forms of intelligence are required (but not easily compatible), transport is too narrow a term, and innovation results in new socio-technical systems. An exploration of cumulative, collective and collaborative aspects of mobility systems, allows us to sketch challenges and opportunities in relation to practices of collaboration, communication and coordination, literacies for creativity, comfort and control, citizenship and (lack of) a sense of crisis, concluding with a discussion of methodological implications.

  10. The Almajiri educational system in Nigeria: cost and challenges ...

    African Journals Online (AJOL)

    This paper highlights the cost and challenges of the Almajiri system of education in Nigeria. The paper theoretically examines pertinent issues arising from its conduct and administration. Although the Almajiri system of education in Nigeria has attracted very large number of children in the Northern part of the country, it has ...

  11. Preferences in Interactive Systems: Technical Challenges and Case Studies

    OpenAIRE

    Peintner, Bart; Viappiani, Paolo; Yorke-Smith, Neil

    2008-01-01

    Interactive artificial intelligence systems employ preferences in both their reasoning and their interaction with the user. This survey considers preference handling in applications such as recommender systems, personal assistant agents, and personalized user interfaces. We survey the major questions and approaches, present illustrative examples, and give an outlook on potential benefits and challenges.

  12. Bio- and ecological systems: Challenges, accomplishments and forecasts

    NARCIS (Netherlands)

    Carson, E.; Feng, D.D.; Pons, M.N.; Soncini-Sessa, R.; Straten, van G.

    2009-01-01

    Abstract The complexities of the dynmic processes and their control associated with bio- and ecological systems offer many challenges for the control engineer. Applying dynamic modelling and control can aid understanding of their complexities. Moreover,using such complex systems as test-beds for new

  13. Shared Electronic Health Record Systems: Key Legal and Security Challenges.

    Science.gov (United States)

    Christiansen, Ellen K; Skipenes, Eva; Hausken, Marie F; Skeie, Svein; Østbye, Truls; Iversen, Marjolein M

    2017-11-01

    Use of shared electronic health records opens a whole range of new possibilities for flexible and fruitful cooperation among health personnel in different health institutions, to the benefit of the patients. There are, however, unsolved legal and security challenges. The overall aim of this article is to highlight legal and security challenges that should be considered before using shared electronic cooperation platforms and health record systems to avoid legal and security "surprises" subsequent to the implementation. Practical lessons learned from the use of a web-based ulcer record system involving patients, community nurses, GPs, and hospital nurses and doctors in specialist health care are used to illustrate challenges we faced. Discussion of possible legal and security challenges is critical for successful implementation of shared electronic collaboration systems. Key challenges include (1) allocation of responsibility, (2) documentation routines, (3) and integrated or federated access control. We discuss and suggest how challenges of legal and security aspects can be handled. This discussion may be useful for both current and future users, as well as policy makers.

  14. Methods and metrics challenges of delivery-system research

    Directory of Open Access Journals (Sweden)

    Alexander Jeffrey A

    2012-03-01

    Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

  15. Challenges in the analysis of complex systems: introduction and overview

    Science.gov (United States)

    Hastings, Harold M.; Davidsen, Jörn; Leung, Henry

    2017-12-01

    One of the main challenges of modern physics is to provide a systematic understanding of systems far from equilibrium exhibiting emergent behavior. Prominent examples of such complex systems include, but are not limited to the cardiac electrical system, the brain, the power grid, social systems, material failure and earthquakes, and the climate system. Due to the technological advances over the last decade, the amount of observations and data available to characterize complex systems and their dynamics, as well as the capability to process that data, has increased substantially. The present issue discusses a cross section of the current research on complex systems, with a focus on novel experimental and data-driven approaches to complex systems that provide the necessary platform to model the behavior of such systems.

  16. Electronic Payment System in Nigeria: Its Economic Benefits and Challenges

    Science.gov (United States)

    Okifo, Joseph; Igbunu, Richard

    2015-01-01

    The crux of this study is on the adoption of E-payment system in Nigeria: Its economic benefits and challenges. The arrival of the internet has taken electronic payments and transactions to an exponential growth level. Consumers could purchase goods and services from the internet and send unencrypted credit card numbers across the network, which…

  17. Material challenges for the next generation of fission reactor systems

    International Nuclear Information System (INIS)

    Buckthorpe, Derek

    2010-01-01

    The new generation of fission reactor systems wil require the deployment and construction of a series of advanced water cooled reactors as part of a package of measures to meet UK and European energy needs and to provide a near term non-fossil fuel power solution that addresses CO 2 emission limits. In addition new longer term Generation IV reactor tye systems are being developed and evaluated to enhance safety, reliability, sustainability economics and proliferation resistance requirements and to meet alternative energy applications (outside of electricity generation) such as process heat and large scale hydrogen generation. New fission systems will impose significant challenges on materials supply and development. In the near term, because of the need to 'gear up' to large scale construction after decades of industrial hibernation/contraction and, in the longer term, because of the need for materials to operate under more challenging environments requiring the deployment and development of new alternative materials not yet established to an industrial stage. This paper investigates the materials challenges imposed by the new Generation III+ and Generation IV systems. These include supply and fabrication issues, development of new high temperature alloys and non-metallic materials, the use of new methods of manufacture and the best use of currently available resources and minerals. Recommendations are made as to how these materials challenges might be met and how governments, industry, manufacturers and researchers can all play their part. (orig.)

  18. Human capital flight challenges within an Equitable Health System ...

    African Journals Online (AJOL)

    Human capital flight challenges within an Equitable Health System. N E Udonwa. Abstract. No Abstract Nigerian Journal of Medicine Vol. 16 (4) 2007: pp. 307-311. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/njm.v16i4.37327 · AJOL African ...

  19. Control Engineering, System Theory and Mathematics: The Teacher's Challenge

    Science.gov (United States)

    Zenger, K.

    2007-01-01

    The principles, difficulties and challenges in control education are discussed and compared to the similar problems in the teaching of mathematics and systems science in general. The difficulties of today's students to appreciate the classical teaching of engineering disciplines, which are based on rigorous and scientifically sound grounds, are…

  20. Material challenges for the next generation of fission reactor systems

    Energy Technology Data Exchange (ETDEWEB)

    Buckthorpe, Derek [AMEC, Knutsford, Cheshire (United Kingdom)

    2010-07-01

    The new generation of fission reactor systems wil require the deployment and construction of a series of advanced water cooled reactors as part of a package of measures to meet UK and European energy needs and to provide a near term non-fossil fuel power solution that addresses CO{sub 2} emission limits. In addition new longer term Generation IV reactor tye systems are being developed and evaluated to enhance safety, reliability, sustainability economics and proliferation resistance requirements and to meet alternative energy applications (outside of electricity generation) such as process heat and large scale hydrogen generation. New fission systems will impose significant challenges on materials supply and development. In the near term, because of the need to 'gear up' to large scale construction after decades of industrial hibernation/contraction and, in the longer term, because of the need for materials to operate under more challenging environments requiring the deployment and development of new alternative materials not yet established to an industrial stage. This paper investigates the materials challenges imposed by the new Generation III+ and Generation IV systems. These include supply and fabrication issues, development of new high temperature alloys and non-metallic materials, the use of new methods of manufacture and the best use of currently available resources and minerals. Recommendations are made as to how these materials challenges might be met and how governments, industry, manufacturers and researchers can all play their part. (orig.)

  1. Nanomedical device and systems design challenges, possibilities, visions

    CERN Document Server

    2014-01-01

    Nanomedical Device and Systems Design: Challenges, Possibilities, Visions serves as a preliminary guide toward the inspiration of specific investigative pathways that may lead to meaningful discourse and significant advances in nanomedicine/nanotechnology. This volume considers the potential of future innovations that will involve nanomedical devices and systems. It endeavors to explore remarkable possibilities spanning medical diagnostics, therapeutics, and other advancements that may be enabled within this discipline. In particular, this book investigates just how nanomedical diagnostic and

  2. Challenges to China's transition to a low carbon electricity system

    International Nuclear Information System (INIS)

    Kahrl, Fredrich; Williams, Jim; Ding Jianhua; Hu Junfeng

    2011-01-01

    We examine the challenges to China's transition to a low carbon electricity system, in which renewable energy would play a significant role. China's electricity system currently lacks the flexibility in planning, operations, and pricing to respond to conflicting pressures from demand growth, rising costs, and environmental mandates in a way that simultaneously maintains reliability, decarbonizes the system, and keeps prices within acceptable bounds. Greater flexibility crucially requires the ability to more systematically and transparently manage and allocate costs. This will require re-orientating sector institutions still rooted in central planning, and strengthening independent regulation. Some of the necessary changes require fundamental political and legal reforms beyond the scope of energy policy. However, the system's flexibility can still be increased through the development of traditional planning and regulatory tools and approaches, such as an avoided cost basis for energy efficiency investments, more integrated planning to improve the coordination of generation, transmission, and demand-side investments, and a transparent ratemaking process. The judicious application of OECD electricity sector experience and skills can support these developments. - Research highlights: → China's electricity system currently lacks the flexibility to integrate renewables and reduce CO 2 emissions on a large scale at an acceptable cost and level of reliability. → The challenges to increased flexibility are more institutional than technological. → Chinese government agencies need new approaches to basic power system planning and ratemaking. → OECD countries can help address these challenges through the transfer of 'soft' technologies.

  3. The Challenges Confronting Public Hospitals in India, Their Origins, and Possible Solutions

    Directory of Open Access Journals (Sweden)

    Vikas Bajpai

    2014-01-01

    Full Text Available Despite the implementation of National Rural Health Mission over a period of nine years since 2005, the public health system in the country continues to face formidable challenges. In the context of plans for rolling out “Universal Health Care” in the country, this paper analyzes the social, economic, and political origins of the major challenges facing public hospitals in India. The view taken therein holds the class nature of the ruling classes in the country and the development paradigm pursued by them as being at the root of the present problems being faced by public hospitals. The suggested solutions are in tune with these realities.

  4. Innovation in Extraterrestrial Service Systems - A Challenge for Service Science

    Science.gov (United States)

    Bergner, David

    2010-01-01

    This presentation was prepared at the invitation of Professor Yukio Ohsawa, Department of Systems Innovation, School of Engineering, The University of Tokyo, for delivery at the International Workshop on Innovating Service Systems, sponsored by the Japanese Society of Artificial Intelligence (JSAI) as part of the JSAI Internation Symposium on AI, 2010. It offers several challenges for Service Science and Service Innovation. the goal of the presentation is to stimulate thinking about how service systems viII evolve in the future, as human society advances from its terrestrial base toward a permanent presence in space. First we will consider the complexity of the International Space Station (ISS) as it is today, with particular emphasis of its research facilities, and focus on a current challenge - to maximize the utilization of ISS research facilities for the benefit of society. After briefly reviewing the basic principles of Service Science, we will discuss the potential application of Service Innovation methodology to this challenge. Then we viII consider how game-changing technologies - in particular Synthetic Biology - could accelerate the pace of sociocultural evolution and consequently, the progression of human society into space. We will use this provocative vision to advance thinking about how the emerging field of Service Science, Management, and Engineering (SSME) might help us anticipate and better handle the challenges of this inevitable evolutionary process.

  5. A Systems Thinking Approach to Engineering Challenges of Military Systems-of-Systems

    Science.gov (United States)

    2016-09-01

    particular in aspects of cooperation, interoperability, joint effects, emergent behaviours and uncertainties. SoS development state management is...processes. Inadequate understanding of SoS problems and inability to manage complexity encountered in planning, development and operation of...Systems (SoS) is broadly acknowledged as an engineering and management challenge for defence organisations, in particular in pursuing joint force

  6. Assessment in Open and Distance Learning System (ODL: A Challenge

    Directory of Open Access Journals (Sweden)

    S. V. S. Chaudhary

    2013-09-01

    Full Text Available Assessment is an integral part of the learning process. The traditional practice of assessment has changed to meet the need of the contemporary society. In this paper assessment strategies used in Open and Distance Education are discussed and constructive suggestions are given to meet the challenges of assessment. Recently we experience a paradigm shift in assessment both in face-to-face and ODL system. Content-based testing has shifted to performance-based assessment. Assessment is no longer used for grading and certification, rather it has linked with learning and skill development of the students. Instead of a single paper pencil test, a variety of techniques and methods are being increasingly conducted. In this context assessment in the ODL system has adopted a new shape to provide better assessment judgments to its students and at the same time helping teachers and administrators. Coping with the changing scenario in ODL we face challenges addressed extensively in this article.

  7. Environmental Accounting – A New Challenge for the Accounting System

    OpenAIRE

    Hajnalka Ván

    2012-01-01

    The appearance of environmental problems impacts every area of science globally, as a result, accounting has to answer these challenges as well, one way of which is environmental accounting. The main aim of the study is explore the roots and the tendencies of the development of environmental accounting. In addition, environmental accounting will also be discussed in terms of its relevance to supplementing the traditional accounting system, which topic will be concluded with an outlook on Hung...

  8. Assessment in Open and Distance Learning System (ODL): A Challenge

    OpenAIRE

    Chaudhary, S. V. S.; Dey, Niradhar

    2013-01-01

    Assessment is an integral part of the learning process. The traditional practice of assessment has changed to meet the need of the contemporary society. In this paper assessment strategies used in Open and Distance Education are discussed and constructive suggestions are given to meet the challenges of assessment. Recently we experience a paradigm shift in assessment both in face-to-face and ODL system. Content-based testing has shifted to performance-based assessment. Assessment is no longer...

  9. Smart wearable systems: current status and future challenges.

    Science.gov (United States)

    Chan, Marie; Estève, Daniel; Fourniols, Jean-Yves; Escriba, Christophe; Campo, Eric

    2012-11-01

    Extensive efforts have been made in both academia and industry in the research and development of smart wearable systems (SWS) for health monitoring (HM). Primarily influenced by skyrocketing healthcare costs and supported by recent technological advances in micro- and nanotechnologies, miniaturisation of sensors, and smart fabrics, the continuous advances in SWS will progressively change the landscape of healthcare by allowing individual management and continuous monitoring of a patient's health status. Consisting of various components and devices, ranging from sensors and actuators to multimedia devices, these systems support complex healthcare applications and enable low-cost wearable, non-invasive alternatives for continuous 24-h monitoring of health, activity, mobility, and mental status, both indoors and outdoors. Our objective has been to examine the current research in wearable to serve as references for researchers and provide perspectives for future research. Herein, we review the current research and development of and the challenges facing SWS for HM, focusing on multi-parameter physiological sensor systems and activity and mobility measurement system designs that reliably measure mobility or vital signs and integrate real-time decision support processing for disease prevention, symptom detection, and diagnosis. For this literature review, we have chosen specific selection criteria to include papers in which wearable systems or devices are covered. We describe the state of the art in SWS and provide a survey of recent implementations of wearable health-care systems. We describe current issues, challenges, and prospects of SWS. We conclude by identifying the future challenges facing SWS for HM. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Big data in complex systems challenges and opportunities

    CERN Document Server

    Azar, Ahmad; Snasael, Vaclav; Kacprzyk, Janusz; Abawajy, Jemal

    2015-01-01

    This volume provides challenges and Opportunities with updated, in-depth material on the application of Big data to complex systems in order to find solutions for the challenges and problems facing big data sets applications. Much data today is not natively in structured format; for example, tweets and blogs are weakly structured pieces of text, while images and video are structured for storage and display, but not for semantic content and search. Therefore transforming such content into a structured format for later analysis is a major challenge. Data analysis, organization, retrieval, and modeling are other  foundational challenges treated in this book. The material of this book will be useful for researchers and practitioners in the field of big data as well as advanced undergraduate and graduate  students. Each of the 17 chapters in the book opens with a chapter abstract and key terms list. The chapters are organized along the lines of problem description, related works, and analysis of the results and ...

  11. Pilot Implementation of Health Information Systems: Issues and challenges

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2009-01-01

    Pilot implementation is a powerful and widely used approach in identifying design flaws and implementation issues before the full-scale deployment of new health information systems. However, pilot implementations often fail in the sense that they say little about the usability and usefulness...... information system. Based on the findings from this study, we identify three main challenges: (1) defining an appropriate scope for pilot implementation, (2) managing the implementation process, and (3) ensuring commitment to the pilot. Finally, recommendations for future research and implications...

  12. Challenges at different stages of an iris based biometric system

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Singla

    2012-04-01

    Full Text Available Iris recognition has been used for authentication for the past few years and is capable of positive/negative authenticationof an individual without any physical contact or intervention. This technique is being used mainly because of its uniqueness,stability, and reliability but still many challenges are being faced an the iris based recognition system. This paperpresents the difficulties faced in different modules, like the sensor module, preprocessing module, feature extraction module,and matching module of an iris biometric system.

  13. Challenges in designing interactive systems for emergency response

    DEFF Research Database (Denmark)

    Kristensen, Margit; Kyng, Morten; Nielsen, Esben Toftdahl

    2007-01-01

    and visions as ways to bridge between fieldwork and literature studies on the one hand and the emerging computer based prototypes on the other. Our case concerns design of innovative interactive systems for support in emergency response, including patient identification and monitoring as well as construction......This paper presents research on participatory design of interactive systems for emergency response. We present the work by going through the design method with a focus on the new elements that we developed for the participatory design toolkit, in particular we emphasize the use of challenges...... and maintenance of a situational overview....

  14. System-level challenges in pressure-operated soft robotics

    Science.gov (United States)

    Onal, Cagdas D.

    2016-05-01

    Last decade witnessed the revival of fluidic soft actuation. As pressure-operated soft robotics becomes more popular with promising recent results, system integration remains an outstanding challenge. Inspired greatly by biology, we envision future robotic systems to embrace mechanical compliance with bodies composed of soft and hard components as well as electronic and sensing sub-systems, such that robot maintenance starts to resemble surgery. In this vision, portable energy sources and driving infrastructure plays a key role to offer autonomous many-DoF soft actuation. On the other hand, while offering many advantages in safety and adaptability to interact with unstructured environments, objects, and human bodies, mechanical compliance also violates many inherent assumptions in traditional rigid-body robotics. Thus, a complete soft robotic system requires new approaches to utilize proprioception that provides rich sensory information while remaining flexible, and motion control under significant time delay. This paper discusses our proposed solutions for each of these system-level challenges in soft robotics research.

  15. Challenges in data science: a complex systems perspective

    International Nuclear Information System (INIS)

    Carbone, Anna; Jensen, Meiko; Sato, Aki-Hiro

    2016-01-01

    The ability to process and manage large data volumes has been proven to be not enough to tackle the current challenges presented by “Big Data”. Deep insight is required for understanding interactions among connected systems, space- and time- dependent heterogeneous data structures. Emergence of global properties from locally interacting data entities and clustering phenomena demand suitable approaches and methodologies recently developed in the foundational area of Data Science by taking a Complex Systems standpoint. Here, we deal with challenges that can be summarized by the question: “What can Complex Systems Science contribute to Big Data? ”. Such question can be reversed and brought to a superior level of abstraction by asking “What Knowledge can be drawn from Big Data?” These aspects constitute the main motivation behind this article to introduce a volume containing a collection of papers presenting interdisciplinary advances in the Big Data area by methodologies and approaches typical of the Complex Systems Science, Nonlinear Systems Science and Statistical Physics.

  16. Challenge of Replacing Obsolete Equipment and Systems on Brownfield Sites

    International Nuclear Information System (INIS)

    Teasdale, St.

    2009-01-01

    The Nuclear Decommissioning Authority (NDA) is responsible for the decommissioning and clean-up of the UK's civil public sector nuclear sites. One of their top priorities is the retrieval of sludge and fuel from the First Generation Magnox Fuel Storage Pond (FGMSP) at Sellafield site which is one of the most complex and compact nuclear sites in the world. The FGMSP plant is currently undergoing a series of major modifications in preparation for the retrievals operations. One of the most challenging modifications undertaken in the facility has been the Control and Surveillance Project which covered replacement of the existing Environmental Monitoring System, this presented the complex challenge of replacing an existing system whilst maintaining full functionality on a live radiological safety system with a constant radiological hazard. The Control and Surveillance Project involved the design, procurement, installation, changeover and commissioning of a new Radiological Surveillance System (alpha, beta and gamma monitoring) along with Building Evacuation Systems within the FGMSP complex to replace the existing obsolete system. This Project was a key enabler to future FGMSP retrievals and decommissioning activities. The project objective was to create and maintain a safe radiological working environment for over 450 personnel working in the plant up to 2020. The Legacy Ponds at Sellafield represent one of the biggest challenges in the civil nuclear clean up portfolio in the UK. Retrieval of sludge and fuel from the First Generation Magnox Fuel Storage Pond (FGMSP), and its safe long term storage is one of the NDA's top priorities. In June 2002 Sellafield Ltd contracted with the ACKtiv Nuclear Joint Venture to progress the risk mitigation, asset restoration and the early enabling works associated with preparation for clean up. Since then significant progress has been made in preparing the facility, and it's support systems, for the clean-up operations. This has been

  17. Accomplishments and challenges in development of an autonomous operation system

    International Nuclear Information System (INIS)

    Endou, A.; Saiki, A.; Yoshikawa, S.; Okusa, K.; Suda, K.

    1994-01-01

    The authors are studying an autonomous operation system for nuclear power plants in which AI plays key roles as an alternative of plant operators and traditional controllers. In contrast with past studies dedicated to assist the operators, the ultimate target of development of the autonomous operation system is to operate the nuclear plants by AI. To realize humanlike decision-making process by means of AI, the authors used a model-based approach from multiple viewpoints and methodology diversity. A hierarchical distributed cooperative multi-agent system configuration is adopted to allow to incorporate diversified methodologies and to dynamically reorganize system functions. In the present paper, accomplishments to date in the course of the development are described. Challenges for developing methodologies to attain dynamic reorganization are also addressed. (author)

  18. Challenges in Quantitative Abstractions for Collective Adaptive Systems

    Directory of Open Access Journals (Sweden)

    Mirco Tribastone

    2016-07-01

    Full Text Available Like with most large-scale systems, the evaluation of quantitative properties of collective adaptive systems is an important issue that crosscuts all its development stages, from design (in the case of engineered systems to runtime monitoring and control. Unfortunately it is a difficult problem to tackle in general, due to the typically high computational cost involved in the analysis. This calls for the development of appropriate quantitative abstraction techniques that preserve most of the system's dynamical behaviour using a more compact representation. This paper focuses on models based on ordinary differential equations and reviews recent results where abstraction is achieved by aggregation of variables, reflecting on the shortcomings in the state of the art and setting out challenges for future research.

  19. The Evolution and Challenges of the Danish Civil Service System

    DEFF Research Database (Denmark)

    Hansen, Morten Balle

    2013-01-01

    In this article a descriptive analysis of the evolution and current challenges of the Danish civil service system is given. The focus is on the state administration. Theories of path-dependency and the transnational diffusion of ideas inform the empirical analysis. The broad features of the long......-term history of the Danish civil service system are analyzed. The basic characteristics of the current internal labor market of the civil service are analyzed as well as some recent changes in the system. Issues of politicization of the civil service are discussed and public opinion concerning the civil...... service is examined. The Danish civil service system has been characterized by long-term gradual evolution and adoption of many of the prevailing institutions in medieval and modern European state administration. This adaptation to prevailing trends has been predominantly characterized by integration...

  20. International outsourcing as a challenge for the world trade system

    Directory of Open Access Journals (Sweden)

    Elena Sivacheva

    2007-02-01

    Full Text Available From the strategic management point of view, the twenty-first century is being widely recognized as the century for outsourcing in the global economy. In the meantime international outsourcing is one of the most dynamic, innovation-driven and complicated processes in modern world. The present paper concentrates on the essence of international outsourcing (tracing its roots in the international division of labour and world economic relations theoretical approaches, reviews its explicit and implicit challenges and finally presents opportunities for regulating international outsourcing. Attention is focused on the following key questions: to what extent does international outsourcing represent a challenge for the world trade system? what contribution does international outsourcing make to economic «strength» in the modern world?

  1. Progress and challenges to the global waste management system.

    Science.gov (United States)

    Singh, Jagdeep; Laurenti, Rafael; Sinha, Rajib; Frostell, Björn

    2014-09-01

    Rapid economic growth, urbanization and increasing population have caused (materially intensive) resource consumption to increase, and consequently the release of large amounts of waste to the environment. From a global perspective, current waste and resource management lacks a holistic approach covering the whole chain of product design, raw material extraction, production, consumption, recycling and waste management. In this article, progress and different sustainability challenges facing the global waste management system are presented and discussed. The study leads to the conclusion that the current, rather isolated efforts, in different systems for waste management, waste reduction and resource management are indeed not sufficient in a long term sustainability perspective. In the future, to manage resources and wastes sustainably, waste management requires a more systems-oriented approach that addresses the root causes for the problems. A specific issue to address is the development of improved feedback information (statistics) on how waste generation is linked to consumption. © The Author(s) 2014.

  2. System dynamics of electrified vehicles: some facts, thoughts, and challenges

    Science.gov (United States)

    Rauh, Jochen; Ammon, Dieter

    2011-07-01

    Mainly motivated by ecological aspects and the resulting worldwide regulations, electrified vehicles are getting increasing attention from researchers, car manufacturers, and consumers. While most discussions are focusing on the hybrid or completely electric propulsion technologies, this contribution will focus on the aspects of system dynamics related to electrified vehicles. Most of the aspects discussed here are also interesting for vehicles with conventional combustion engines, which will be dominating the mobility market for many years to come. Here, after discussing some basic principles of energy consumption and recuperation potentials, chassis systems are discussed with respect to energy efficiency and fitness for electrified vehicles. Further on, some system implementations are presented to show promising or already successful solutions to the arising challenges.

  3. Information management challenges of the EOS Data and Information System

    Science.gov (United States)

    Mcdonald, Kenneth R.; Blake, Deborah J.

    1991-01-01

    An overview of the current information management concepts that are embodied in the plans for the Earth Observing System Data and Information System (EOSDIS) is presented, and some of the technology development and application areas that are envisioned to be particularly challenging are introduced. The Information Management System (IMS) is the EOSDIS element that provides the primary interface between the science users and the data products and services of EOSDIS. The goals of IMS are to define a clear and complete set of functional requirements and to apply innovative methods and technologies to satisfy them. The information management functions are described in detail, and some applicable technolgies are discussed. Some of the general issues affecting the successful development and operation of the information management element are addressed.

  4. Pedotransfer Functions in Earth System Science: Challenges and Perspectives

    Science.gov (United States)

    Van Looy, Kris; Bouma, Johan; Herbst, Michael; Koestel, John; Minasny, Budiman; Mishra, Umakant; Montzka, Carsten; Nemes, Attila; Pachepsky, Yakov A.; Padarian, José; Schaap, Marcel G.; Tóth, Brigitta; Verhoef, Anne; Vanderborght, Jan; van der Ploeg, Martine J.; Weihermüller, Lutz; Zacharias, Steffen; Zhang, Yonggen; Vereecken, Harry

    2017-12-01

    Soil, through its various functions, plays a vital role in the Earth's ecosystems and provides multiple ecosystem services to humanity. Pedotransfer functions (PTFs) are simple to complex knowledge rules that relate available soil information to soil properties and variables that are needed to parameterize soil processes. In this paper, we review the existing PTFs and document the new generation of PTFs developed in the different disciplines of Earth system science. To meet the methodological challenges for a successful application in Earth system modeling, we emphasize that PTF development has to go hand in hand with suitable extrapolation and upscaling techniques such that the PTFs correctly represent the spatial heterogeneity of soils. PTFs should encompass the variability of the estimated soil property or process, in such a way that the estimation of parameters allows for validation and can also confidently provide for extrapolation and upscaling purposes capturing the spatial variation in soils. Most actively pursued recent developments are related to parameterizations of solute transport, heat exchange, soil respiration, and organic carbon content, root density, and vegetation water uptake. Further challenges are to be addressed in parameterization of soil erosivity and land use change impacts at multiple scales. We argue that a comprehensive set of PTFs can be applied throughout a wide range of disciplines of Earth system science, with emphasis on land surface models. Novel sensing techniques provide a true breakthrough for this, yet further improvements are necessary for methods to deal with uncertainty and to validate applications at global scale.

  5. Security Challenges in Smart-Grid Metering and Control Systems

    Directory of Open Access Journals (Sweden)

    Xinxin Fan

    2013-07-01

    Full Text Available The smart grid is a next-generation power system that is increasingly attracting the attention of government, industry, and academia. It is an upgraded electricity network that depends on two-way digital communications between supplier and consumer that in turn give support to intelligent metering and monitoring systems. Considering that energy utilities play an increasingly important role in our daily life, smart-grid technology introduces new security challenges that must be addressed. Deploying a smart grid without adequate security might result in serious consequences such as grid instability, utility fraud, and loss of user information and energy-consumption data. Due to the heterogeneous communication architecture of smart grids, it is quite a challenge to design sophisticated and robust security mechanisms that can be easily deployed to protect communications among different layers of the smart grid-infrastructure. In this article, we focus on the communication-security aspect of a smart-grid metering and control system from the perspective of cryptographic techniques, and we discuss different mechanisms to enhance cybersecurity of the emerging smart grid. We aim to provide a comprehensive vulnerability analysis as well as novel insights on the cybersecurity of a smart grid.

  6. Achieving Equity in an Evolving Healthcare System: Opportunities and Challenges.

    Science.gov (United States)

    Williams, Joni Strom; Walker, Rebekah J; Egede, Leonard E

    2016-01-01

    For decades, disparities in health have been well documented in the United States and regrettably, remain prevalent despite evidence and appeals for their elimination. Compared with the majority, racial and ethnic minorities continue to have poorer health status and health outcomes for most chronic conditions, including diabetes mellitus, cardiovascular disease, cancer and end-stage renal disease. Many factors, such as affordability, access and diversity in the healthcare system, influence care and outcomes, creating challenges that make the task of eliminating health disparities and achieving health equity daunting and elusive. Novel strategies are needed to bring about much needed change in the complex and evolving United States healthcare system. Although not exhaustive, opportunities such as (1) developing standardized race measurements across health systems, (2) implementing effective interventions, (3) improving workforce diversity, (4) using technological advances and (5) adopting practices such as personalized medicine may serve as appropriate starting points for moving toward health equity. Over the past several decades, diversity in the U.S. population has increased significantly and is expected to increase exponentially in the near future. As the population becomes more diverse, it is important to recognize the possibilities of new and emerging disparities. It is imperative that steps are taken to eliminate the current gap in care and prevent new disparities from developing. Therefore, we present challenges and offer recommendations for facilitating the process of eliminating health disparities and achieving health equity across diverse populations. Published by Elsevier Inc.

  7. Opportunities and challenges for multicriteria assessment of food system sustainability

    Directory of Open Access Journals (Sweden)

    Hugo F. Alrøe

    2016-03-01

    Full Text Available The focus of the Special Feature on "Multicriteria assessment of food system sustainability" is on the complex challenges of making and communicating overall assessments of food systems sustainability based on multiple and varied criteria. Four papers concern the choice and development of appropriate tools for making multicriteria sustainability assessments that handle built-in methodological conflicts and trade-offs between different assessment objectives. They underscore the value of linking diverse methods and tools, or nesting and stepping their deployment, to help build resilience and sustainability. They conclude that there is no one tool, one framework, or one indicator set that is appropriate for the different purposes and contexts of sustainability assessment. The process of creating the assessment framework also emerges as important: if the key stakeholders are not given a responsible and full role in the development of any assessment tool, it is less likely to be fit for their purpose and they are unlikely to take ownership or have confidence in it. Six other papers reflect on more fundamental considerations of how assessments are based in different scientific perspectives and on the role of values, motivation, and trust in relation to assessments in the development of more sustainable food systems. They recommend a radical break with the tradition of conducting multicriteria assessment from one hegemonic perspective to considering multiple perspectives. Collectively the contributions to this Special Feature identify three main challenges for improved multicriteria assessment of food system sustainability: (i how to balance different types of knowledge to avoid that the most well-known, precise, or easiest to measure dimensions of sustainability gets the most weight; (ii how to expose the values in assessment tools and choices to allow evaluation of how they relate to the ethical principles of sustainable food systems, to societal

  8. Immigrants and health system challenges to TB control in Oman

    Directory of Open Access Journals (Sweden)

    Fochsen Grethe

    2010-07-01

    Full Text Available Abstract Background During the past three decades, Oman has made significant progress in controlling TB within it's borders. However, the national TB control program elimination target has yet to be reached. This study aims to explore the perceived roles played by the immigrant population and the private health sector in relation to TB control in Oman. Methods We conducted seventeen interviews with different health care providers. The verbatim transcripts were processed using content analysis. Results Three main themes emerged. Firstly the threat of repatriation faced by underprivileged expatriates, secondly the criticized and forgotten private health sector as a key player and thirdly the user and provider barriers faced by Omani patients in the Omani public health system. Conclusions The study has identified some of the challenges and barriers to TB control in Oman. These challenges are mainly related to unintended negative consequences arising from the current repatriation policy of immigrants and to and the lack of involvement of the private sector in TB control. TB control strategies designed to address these challenges are needed, for Oman to reach its TB elimination targets.

  9. Global nurse leader perspectives on health systems and workforce challenges.

    Science.gov (United States)

    Gantz, Nancy Rollins; Sherman, Rose; Jasper, Melanie; Choo, Chua Gek; Herrin-Griffith, Donna; Harris, Kathy

    2012-05-01

    As part of the 2011 annual American Organization of Nurse Executives conference held in San Diego, California, a session was presented that focused on nursing workforce and health systems challenges from a global perspective. This article includes content addressed during the session representing nurse leader perspectives from the UK, Singapore and the USA. Recent events in global economic markets have highlighted the interdependence of countries. There is now a global focus on health-care costs and quality as government leaders struggle to reduce budgets and remain solvent. Finding solutions to these complex problems requires that nurse leaders adopt more of a world view and network with one another as they look for best practices and creative strategies. Nursing leadership challenges such as staffing, competency development, ageing populations, reduced health-care funding and maintaining quality are now common global problems. There is a need for innovation in nursing practice to accommodate the enormous challenges facing nursing's future. Opportunities on an international scale for nurse leaders to have dialogue and network, such as the conference presentation discussed in this article, will become increasingly more important to facilitate the development of innovative leadership strategies. © 2012 Blackwell Publishing Ltd.

  10. New Advances and Challenges of Fall Detection Systems: A Survey

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2018-03-01

    Full Text Available Falling, as one of the main harm threats to the elderly, has drawn researchers’ attentions and has always been one of the most valuable research topics in the daily health-care for the elderly in last two decades. Before 2014, several researchers reviewed the development of fall detection, presented issues and challenges, and navigated the direction for the study in the future. With smart sensors and Internet of Things (IoT developing rapidly, this field has made great progress. However, there is a lack of a review and discussion on novel sensors, technologies and algorithms introduced and employed from 2014, as well as the emerging challenges and new issues. To bridge this gap, we present an overview of fall detection research and discuss the core research questions on this topic. A total of 6830 related documents were collected and analyzed based on the key words. Among these documents, the twenty most influential and highly cited articles are selected and discussed profoundly from three perspectives: sensors, algorithms and performance. The findings would assist researchers in understanding current developments and barriers in the systems of fall detection. Although researchers achieve fruitful work and progress, this research domain still confronts challenges on theories and practice. In the near future, the new solutions based on advanced IoT will sustainably urge the development to prevent falling injuries.

  11. Health recommender systems: concepts, requirements, technical basics and challenges.

    Science.gov (United States)

    Wiesner, Martin; Pfeifer, Daniel

    2014-03-03

    During the last decades huge amounts of data have been collected in clinical databases representing patients' health states (e.g., as laboratory results, treatment plans, medical reports). Hence, digital information available for patient-oriented decision making has increased drastically but is often scattered across different sites. As as solution, personal health record systems (PHRS) are meant to centralize an individual's health data and to allow access for the owner as well as for authorized health professionals. Yet, expert-oriented language, complex interrelations of medical facts and information overload in general pose major obstacles for patients to understand their own record and to draw adequate conclusions. In this context, recommender systems may supply patients with additional laymen-friendly information helping to better comprehend their health status as represented by their record. However, such systems must be adapted to cope with the specific requirements in the health domain in order to deliver highly relevant information for patients. They are referred to as health recommender systems (HRS). In this article we give an introduction to health recommender systems and explain why they are a useful enhancement to PHR solutions. Basic concepts and scenarios are discussed and a first implementation is presented. In addition, we outline an evaluation approach for such a system, which is supported by medical experts. The construction of a test collection for case-related recommendations is described. Finally, challenges and open issues are discussed.

  12. Health Recommender Systems: Concepts, Requirements, Technical Basics and Challenges

    Directory of Open Access Journals (Sweden)

    Martin Wiesner

    2014-03-01

    Full Text Available During the last decades huge amounts of data have been collected in clinical databases representing patients’ health states (e.g., as laboratory results, treatment plans, medical reports. Hence, digital information available for patient-oriented decision making has increased drastically but is often scattered across different sites. As as solution, personal health record systems (PHRS are meant to centralize an individual’s health data and to allow access for the owner as well as for authorized health professionals. Yet, expert-oriented language, complex interrelations of medical facts and information overload in general pose major obstacles for patients to understand their own record and to draw adequate conclusions. In this context, recommender systems may supply patients with additional laymen-friendly information helping to better comprehend their health status as represented by their record. However, such systems must be adapted to cope with the specific requirements in the health domain in order to deliver highly relevant information for patients. They are referred to as health recommender systems (HRS. In this article we give an introduction to health recommender systems and explain why they are a useful enhancement to PHR solutions. Basic concepts and scenarios are discussed and a first implementation is presented. In addition, we outline an evaluation approach for such a system, which is supported by medical experts. The construction of a test collection for case-related recommendations is described. Finally, challenges and open issues are discussed.

  13. Mobile healthcare applications: system design review, critical issues and challenges.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Connolly, Martin J

    2015-03-01

    Mobile phones are becoming increasingly important in monitoring and delivery of healthcare interventions. They are often considered as pocket computers, due to their advanced computing features, enhanced preferences and diverse capabilities. Their sophisticated sensors and complex software applications make the mobile healthcare (m-health) based applications more feasible and innovative. In a number of scenarios user-friendliness, convenience and effectiveness of these systems have been acknowledged by both patients as well as healthcare providers. M-health technology employs advanced concepts and techniques from multidisciplinary fields of electrical engineering, computer science, biomedical engineering and medicine which benefit the innovations of these fields towards healthcare systems. This paper deals with two important aspects of current mobile phone based sensor applications in healthcare. Firstly, critical review of advanced applications such as; vital sign monitoring, blood glucose monitoring and in-built camera based smartphone sensor applications. Secondly, investigating challenges and critical issues related to the use of smartphones in healthcare including; reliability, efficiency, mobile phone platform variability, cost effectiveness, energy usage, user interface, quality of medical data, and security and privacy. It was found that the mobile based applications have been widely developed in recent years with fast growing deployment by healthcare professionals and patients. However, despite the advantages of smartphones in patient monitoring, education, and management there are some critical issues and challenges related to security and privacy of data, acceptability, reliability and cost that need to be addressed.

  14. Polypathology, an emerging phenomenon and a challenge for healthcare systems.

    Science.gov (United States)

    Román, P; Ruiz-Cantero, A

    2017-05-01

    Improvements in living conditions and scientific advances have led to an unprecedented demographic change. The curing of numerous acute diseases and the growing adoption of unhealthy lifestyles have caused a pandemic of cumulative chronic diseases that constitute the leading cause of death worldwide. Currently, the most common situation is the coexistence of multiple chronic diseases (or polypathology). This situation undermines socio-economic development and increases inequality. This results in an overriding need to change the way in which health and disease are addressed. Healthcare systems are not prepared to meet the needs of complex polypathological patients. In this article, we summarise the challenges facing healthcare systems and states, as well as the main recommendations from the organisations responsible for healthcare. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  15. Nonviral Delivery Systems For Cancer Gene Therapy: Strategies And Challenges.

    Science.gov (United States)

    Shim, Gayong; Kim, Dongyoon; Le, Quoc-Viet; Park, Gyu Thae; Kwon, Taekhyun; Oh, Yu-Kyoung

    2018-01-19

    Gene therapy has been receiving widespread attention due to its unique advantage in regulating the expression of specific target genes. In the field of cancer gene therapy, modulation of gene expression has been shown to decrease oncogenic factors in cancer cells or increase immune responses against cancer. Due to the macromolecular size and highly negative physicochemical features of plasmid DNA, efficient delivery systems are an essential ingredient for successful gene therapy. To date, a variety of nanostructures and materials have been studied as nonviral gene delivery systems. In this review, we will cover nonviral delivery strategies for cancer gene therapy, with a focus on target cancer genes and delivery materials. Moreover, we will address current challenges and perspectives for nonviral delivery-based cancer gene therapeutics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  16. Challenges in Data Quality Assurance in Pervasive Health Monitoring Systems

    Science.gov (United States)

    Sriram, Janani; Shin, Minho; Kotz, David; Rajan, Anand; Sastry, Manoj; Yarvis, Mark

    Wearable, portable, and implantable medical sensors have ushered in a new paradigm for healthcare in which patients can take greater responsibility and caregivers can make well-informed, timely decisions. Health-monitoring systems built on such sensors have huge potential benefit to the quality of healthcare and quality of life for many people, such as patients with chronic medical conditions (such as blood-sugar sensors for diabetics), people seeking to change unhealthy behavior (such as losing weight or quitting smoking), or athletes wishing to monitor their condition and performance. To be effective, however, these systems must provide assurances about the quality of the sensor data. The sensors must be applied to the patient by a human, and the sensor data may be transported across multiple networks and devices before it is presented to the medical team. While no system can guarantee data quality, we anticipate that it will help for the system to annotate data with some measure of confidence. In this paper, we take a deeper look at potential health-monitoring usage scenarios and highlight research challenges required to ensure and assess quality of sensor data in health-monitoring systems.

  17. Front-end electronics and trigger systems - status and challenges

    International Nuclear Information System (INIS)

    Spieler, Helmuth G; Spieler, Helmuth G

    2007-01-01

    The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not provide the required electronic noise at lower power, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

  18. Membranes for bioelectrochemical systems: challenges and research advances.

    Science.gov (United States)

    Dhar, Bipro Ranjan; Lee, Hyung-Sool

    2013-01-01

    Increasing energy demand has been a big challenge for current society, as the fossil fuel sources are gradually decreasing. Hence, development of renewable and sustainable energy sources for the future is considered one of the top priorities in national strategic plans. Bioenergy can meet future energy requirements - renewability, sustainability, and even carbon-neutrality. Bioenergy production from wastes and wastewaters is especially attractive because of dual benefits of energy generation and contaminant stabilization. There are several bioenergy technologies using wastes and wastewaters as electron donor, which include anaerobic digestion, dark biohydrogen fermentation, biohydrogen production using photosynthetic microorganisms, and bioelectrochemical systems (BESs). Among them BES seems to be very promising as we can produce a variety of value-added products from wastes and wastewaters, such as electric power, hydrogen gas, hydrogen peroxide, acetate, ethanol etc. Most ofthe traditional BES uses a membrane to separate the anode and cathode chamber, which is essential for improving microbial metabolism on the anode and the recovery of value-added products on the cathode. Performance of BES lacking a membrane can be seriously deteriorated, due to oxygen diffusion or substantial loss of synthesized products. For this reason, usage of a membrane seems essential to facilitate BES performance. However, a membrane can bring several technical challenges to BES application compared to membrane-less BES. These challenges include poor proton permeability, substrate loss, oxygen back diffusion, pH gradient, internal resistance, biofouling, etc. This paper aims to review the major technical barriers associated with membranes and future research directions for their application in BESs.

  19. Establishing national medical imaging incident reporting systems: issues and challenges.

    Science.gov (United States)

    Jones, D Neil; Benveniste, Klee A; Schultz, Timothy J; Mandel, Catherine J; Runciman, William B

    2010-08-01

    Radiology incident reporting systems provide one source of invaluable patient safety data that, when combined with appropriate analysis and action, can result in significantly safer health care, which is now an urgent priority for governments worldwide. Such systems require integration into a wider safety, quality, and risk management framework because many issues have global implications, and they also require an international classification scheme, which is now being developed. These systems can be used to inform global research activities as identified by the World Health Organization, many of which intersect with the activities of and issues seen in medical imaging departments. How to ensure that radiologists (and doctors in general) report incidents, and are engaged in the process, is a challenge. However, as demonstrated with the example of the Australian Radiology Events Register, this can be achieved when the reporting system is integrated with their professional organization and its other related activities (such as training and education) and administered by a patient safety organization. Copyright 2010 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  20. Pedotransfer functions in Earth system science: challenges and perspectives

    Science.gov (United States)

    Van Looy, K.; Minasny, B.; Nemes, A.; Verhoef, A.; Weihermueller, L.; Vereecken, H.

    2017-12-01

    We make a stronghold for a new generation of Pedotransfer functions (PTFs) that is currently developed in the different disciplines of Earth system science, offering strong perspectives for improvement of integrated process-based models, from local to global scale applications. PTFs are simple to complex knowledge rules that relate available soil information to soil properties and variables that are needed to parameterize soil processes. To meet the methodological challenges for a successful application in Earth system modeling, we highlight how PTF development needs to go hand in hand with suitable extrapolation and upscaling techniques such that the PTFs correctly capture the spatial heterogeneity of soils. Most actively pursued recent developments are related to parameterizations of solute transport, heat exchange, soil respiration and organic carbon content, root density and vegetation water uptake. We present an outlook and stepwise approach to the development of a comprehensive set of PTFs that can be applied throughout a wide range of disciplines of Earth system science, with emphasis on land surface models. Novel sensing techniques and soil information availability provide a true breakthrough for this, yet further improvements are necessary in three domains: 1) the determining of unknown relationships and dealing with uncertainty in Earth system modeling; 2) the step of spatially deploying this knowledge with PTF validation at regional to global scales; and 3) the integration and linking of the complex model parameterizations (coupled parameterization). Integration is an achievable goal we will show.

  1. Pilot implementation of health information systems: issues and challenges.

    Science.gov (United States)

    Bansler, Jørgen P; Havn, Erling

    2010-09-01

    This study aims to explore the issues and challenges involved in designing and organizing pilot implementations of health information systems (HIS). Pilot implementations are a widely used approach for identifying design flaws and implementation issues before full-scale deployment of new HIS. However, it is not uncommon for pilot implementations to fail in the sense that little can be learned from them. We employed an interpretive case study approach in attempting to throw light on the reasons why pilot implementations sometimes fail. We studied the (failed) pilot implementation of an electronic Pregnancy Record (ePR) in Denmark. Our primary data collection methods comprised participant observations, semi-structured interviews and document analyses. Based on a comprehensive evaluation of the implementation process, we identify three major challenges that complicated the pilot project and eventually led to its failure, namely difficulties in (1) defining an appropriate scope for the pilot implementation, (2) coping with unanticipated technical and practical problems, and (3) ensuring commitment from test users and their managers. Pilot implementations are a very useful technique for developing HIS, but also one that is very difficult to do successfully. It is sometimes assumed that pilot implementations are less complicated and risky than regular, full-scale implementations. However, pilot implementations are not just small-scale versions of conventional implementations; they are fundamentally different and they have their own complications and issues to deal with that make them hard to design and manage. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  2. Fourth Data Challenge for the ALICE data acquisition system

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ALICE experiment will study quark-gluon plasma using beams of heavy ions, such as those of lead. The particles in the beams will collide thousands of times per second in the detector and each collision will generate an event containing thousands of charged particles. Every second, the characteristics of tens of thousands of particles will have to be recorded. Thus, to be effective, the data acquisition system (DAQ) must meet extremely strict performance criteria. To this end, the ALICE Data Challenges entail step-by-step testing of the DAQ with existing equipment that is sufficiently close to the final equipment to provide a reliable indication of performance. During the fourth challenge, in 2002, a data acquisition rate of 1800 megabytes per second was achieved by using some thirty parallel-linked PCs running the specially developed DATE software. During the final week of tests in December 2002, the team also tested the Storage Tek linear magnetic tape drives. Their bandwidth is 30 megabytes per second a...

  3. Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation.

    Science.gov (United States)

    Paldi, Andras

    2018-01-01

    The cells of a multicellular organism are derived from a single zygote and genetically identical. Yet, they are phenotypically very different. This difference is the result of a process commonly called cell differentiation. How the phenotypic diversity emerges during ontogenesis or regeneration is a central and intensely studied but still unresolved issue in biology. Cell biology is facing conceptual challenges that are frequently confused with methodological difficulties. How to define a cell type? What stability or change means in the context of cell differentiation and how to deal with the ubiquitous molecular variations seen in the living cells? What are the driving forces of the change? We propose to reframe the problem of cell differentiation in a systemic way by incorporating different theoretical approaches. The new conceptual framework is able to capture the insights made at different levels of cellular organization and considered previously as contradictory. It also provides a formal strategy for further experimental studies.

  4. Digital health and the challenge of health systems transformation

    Science.gov (United States)

    Gagnon, Marie-Pierre; Fortin, Jean-Paul

    2017-01-01

    Information and communication technologies have transformed all sectors of society. The health sector is no exception to this trend. In light of “digital health”, we see multiplying numbers of web platforms and mobile health applications, often brought by new unconventional players who produce and offer services in non-linear and non-hierarchal ways, this by multiplying access points to services for people. Some speak of a “uberization” of healthcare. New realities and challenges have emerged from this paradigm, which question the abilities of health systems to cope with new business and economic models, governance of data and regulation. Countries must provide adequate responses so that digital health, based increasingly on disruptive technologies, can benefit for all. PMID:28894741

  5. Pilot Implementation of Health Information Systems: Issues and challenges

    DEFF Research Database (Denmark)

    Bansler, Jørgen Peter; Havn, Erling C.

    2010-01-01

    Objectives: This study aims to explore the issues and challenges involved in designing and organizing pilot implementations of health information systems (HIS). Pilot implementations are a widely used approach for identifying design flaws and implementation issues before full-scale deployment...... of conventional implementations; they are fundamentally different and they have their own complications and issues to deal with that make them hard to design and manage....... of new HIS. However, it is not uncommon for pilot implementations to fail in the sense that little can be learned from them. Method: We employed an interpretive case study approach in attempting to throw light on the reasons why pilot implementations sometimes fail. We studied the (failed) pilot...

  6. Digital health and the challenge of health systems transformation.

    Science.gov (United States)

    Alami, Hassane; Gagnon, Marie-Pierre; Fortin, Jean-Paul

    2017-01-01

    Information and communication technologies have transformed all sectors of society. The health sector is no exception to this trend. In light of "digital health", we see multiplying numbers of web platforms and mobile health applications, often brought by new unconventional players who produce and offer services in non-linear and non-hierarchal ways, this by multiplying access points to services for people. Some speak of a "uberization" of healthcare. New realities and challenges have emerged from this paradigm, which question the abilities of health systems to cope with new business and economic models, governance of data and regulation. Countries must provide adequate responses so that digital health, based increasingly on disruptive technologies, can benefit for all.

  7. Integrating Photovoltaic Systems in Power System: Power Quality Impacts and Optimal Planning Challenges

    Directory of Open Access Journals (Sweden)

    Aida Fazliana Abdul Kadir

    2014-01-01

    Full Text Available This paper is an overview of some of the main issues in photovoltaic based distributed generation (PVDG. A discussion of the harmonic distortion produced by PVDG units is presented. The maximum permissible penetration level of PVDG in distribution system is also considered. The general procedures of optimal planning for PVDG placement and sizing are also explained in this paper. The result of this review shows that there are different challenges for integrating PVDG in the power systems. One of these challenges is integrated system reliability whereas the amount of power produced by renewable energy source is consistent. Thus, the high penetration of PVDG into grid can decrease the reliability of the power system network. On the other hand, power quality is considered one of the challenges of PVDG whereas the high penetration of PVDGs can lead to more harmonic propagation into the power system network. In addition to that, voltage fluctuation of the integrated PVDG and reverse power flow are two important challenges to this technology. Finally, protection of power system with integrated PVDG is one of the most critical challenges to this technology as the current protection schemes are designed for unidirectional not bidirectional power flow pattern.

  8. Integrated Food-Energy Systems: Challenges and Opportunities

    Science.gov (United States)

    Gerst, M.; Cox, M. E.; Locke, K. A.; Laser, M.; Raker, M.; Gooch, C.; Kapuscinski, A. R.

    2015-12-01

    Predominant forms of food and energy systems pose multiple challenges to the environment as current configurations tend to be structured around centralized one-way through-put of materials and energy. One proposed form of system transformation involves locally integrating "unclosed" material and energy loops from food and energy systems. Such systems, which have been termed integrated food-energy systems (IFES), have existed in diverse niche forms but have not been systematically studied with respect to technological, governance, and environmental differences. This is likely because IFES can have widely different configurations, from co-located renewable energy production on cropland to agroforestry. As a first step in creating a synthesis of IFES, our research team constructed a taxonomy using exploratory data analysis of diverse IFES cases (Gerst et al., 2015, ES&T 49:734-741). It was found that IFES may be categorized by type of primary product produced (plant- or animal-based food or energy) and the degree and direction of vertical supply chain coordination. To further explore these implications, we have begun a study of a highly-coordinated, animal-driven IFES: dairy farms with biogas production from anaerobic digestion of manure. The objectives of the research are to understand the barriers to adoption and the potential benefits to the farms financial resilience and to the environment. To address these objectives, we are interviewing 50 farms across New York and Vermont, collecting information on farmer decision-making and farm operation. These results will be used to calibrate biophysical and economic models of the farm in order understand the future conditions under which adoption of an IFES is beneficial.

  9. Inferring connectivity in networked dynamical systems: Challenges using Granger causality

    Science.gov (United States)

    Lusch, Bethany; Maia, Pedro D.; Kutz, J. Nathan

    2016-09-01

    Determining the interactions and causal relationships between nodes in an unknown networked dynamical system from measurement data alone is a challenging, contemporary task across the physical, biological, and engineering sciences. Statistical methods, such as the increasingly popular Granger causality, are being broadly applied for data-driven discovery of connectivity in fields from economics to neuroscience. A common version of the algorithm is called pairwise-conditional Granger causality, which we systematically test on data generated from a nonlinear model with known causal network structure. Specifically, we simulate networked systems of Kuramoto oscillators and use the Multivariate Granger Causality Toolbox to discover the underlying coupling structure of the system. We compare the inferred results to the original connectivity for a wide range of parameters such as initial conditions, connection strengths, community structures, and natural frequencies. Our results show a significant systematic disparity between the original and inferred network, unless the true structure is extremely sparse or dense. Specifically, the inferred networks have significant discrepancies in the number of edges and the eigenvalues of the connectivity matrix, demonstrating that they typically generate dynamics which are inconsistent with the ground truth. We provide a detailed account of the dynamics for the Erdős-Rényi network model due to its importance in random graph theory and network science. We conclude that Granger causal methods for inferring network structure are highly suspect and should always be checked against a ground truth model. The results also advocate the need to perform such comparisons with any network inference method since the inferred connectivity results appear to have very little to do with the ground truth system.

  10. Privacy Management and Networked PPD Systems - Challenges Solutions.

    Science.gov (United States)

    Ruotsalainen, Pekka; Pharow, Peter; Petersen, Francoise

    2015-01-01

    Modern personal portable health devices (PPDs) become increasingly part of a larger, inhomogeneous information system. Information collected by sensors are stored and processed in global clouds. Services are often free of charge, but at the same time service providers' business model is based on the disclosure of users' intimate health information. Health data processed in PPD networks is not regulated by health care specific legislation. In PPD networks, there is no guarantee that stakeholders share same ethical principles with the user. Often service providers have own security and privacy policies and they rarely offer to the user possibilities to define own, or adapt existing privacy policies. This all raises huge ethical and privacy concerns. In this paper, the authors have analyzed privacy challenges in PPD networks from users' viewpoint using system modeling method and propose the principle "Personal Health Data under Personal Control" must generally be accepted at global level. Among possible implementation of this principle, the authors propose encryption, computer understandable privacy policies, and privacy labels or trust based privacy management methods. The latter can be realized using infrastructural trust calculation and monitoring service. A first step is to require the protection of personal health information and the principle proposed being internationally mandatory. This requires both regulatory and standardization activities, and the availability of open and certified software application which all service providers can implement. One of those applications should be the independent Trust verifier.

  11. Management of systemic lupus erythematosus during pregnancy: challenges and solutions.

    Science.gov (United States)

    Knight, Caroline L; Nelson-Piercy, Catherine

    2017-01-01

    Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal-neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy. In pregnancy, early referral for hospital-coordinated care, involvement of obstetricians and rheumatologists (and other specialists as required), an individual management plan, regular reviews, and early recognition of flares and complications are all important. Women are at risk of lupus flares, worsening renal impairment, onset of or worsening hypertension, preeclampsia, and/or venous thromboembolism, and miscarriage, intrauterine growth restriction, preterm delivery, and/or neonatal lupus syndrome (congenital heart block or neonatal lupus erythematosus). A cesarean section may be required in certain obstetric contexts (such as urgent preterm delivery for maternal and/or fetal well-being), but vaginal birth should be the aim for the majority of women. Postnatally, an ongoing individual management plan remains important, with neonatal management where necessary and rheumatology followup. This article explores the challenges at each stage of pregnancy, discusses the effect of SLE on pregnancy and vice versa, and reviews antirheumatic medications with the latest guidance about their use and safety in pregnancy. Such information is required to effectively and safely manage each stage of pregnancy in women with SLE.

  12. Management of systemic lupus erythematosus during pregnancy: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Knight CL

    2017-03-01

    Full Text Available Caroline L Knight, Catherine Nelson-Piercy Division of Women’s Health, Women’s Health Academic Centre, King’s College London and King’s Health Partners, St Thomas’ Hospital, London, UK Abstract: Systemic lupus erythematosus (SLE is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal–neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy. In pregnancy, early referral for hospital-coordinated care, involvement of obstetricians and rheumatologists (and other specialists as required, an individual management plan, regular reviews, and early recognition of flares and complications are all important. Women are at risk of lupus flares, worsening renal impairment, onset of or worsening hypertension, preeclampsia, and/or venous thromboembolism, and miscarriage, intrauterine growth restriction, preterm delivery, and/or neonatal lupus syndrome (congenital heart block or neonatal lupus erythematosus. A cesarean section may be required in certain obstetric contexts (such as urgent preterm delivery for maternal and/or fetal well-being, but vaginal birth should be the aim for the majority of women. Postnatally, an ongoing individual management plan remains important, with neonatal management where necessary and rheumatology follow-up. This article explores the challenges at each stage of pregnancy, discusses the effect of SLE on pregnancy and

  13. Women in Arab countries: challenging the patriarchal system?

    Science.gov (United States)

    Fargues, Philippe

    2005-05-01

    Progress in the empowerment of Arab women was found to be low in a 2002 report. Yet Arab women's status is not reflected in continuing high fertility, which in 2000 had dropped sharply in one generation to 3.4. This paper discusses why fertility decline could nevertheless have taken place in the Arab countries. Islam has not stood in the way of fertility decline, as Iran and Algeria show. From the mid- 1970s to 1980s, subsidised consumption through oil wealth redistribution reduced the cost of children, and social conservatism kept married women out of the labour force, both of which promoted higher fertility. The early stages of fertility decline were mainly due to longer length of education of girls, rising female age at first marriage, e.g. 28 in urban Morocco and 29 in Libya, and entry into the labour force of young, single women. There is also a growing population sub-group of never-married young women. Collapsing oil prices and structural adjustment reduced household resources and became an effective fertility regulation factor. Girls born since the 1950s have not only been educated longer than their mothers, but also their fathers, which increases their authority. These factors, and women's activism and civil and political lobbying for the reform of personal status now underway in a number of Arab countries, could all challenge the patriarchal system.

  14. Challenges of structural materials for innovative nuclear systems in Europe

    International Nuclear Information System (INIS)

    Serrano, M.; Gomez-Briceno, D.

    2009-01-01

    New fusion and fission reactors for generation IV are envisaged to operate at conditions well above the actual ones for commercial fission reactors. This type of reactor combined a high operation temperature with a high neutron dose and an aggressive coolant, which imply new challenges for structural materials. One of the key issues to assure the safety and feasibility of these new nuclear systems is the selection of the structural materials, especially for in core components. Beside the differences between them, especially the amount of transmutation He in fusion reactors, similar structural materials have been selected. Some of the selected materials are well characterized at least at medium temperatures, as conventional ferritic/martensitic steels, but the qualification for higher temperatures is needed. For other materials, as ODS steels, there is a need for a complete characterization and qualification. In this paper a review of the operating conditions and selected structural materials for generation IV and fusion reactors within Europe is made. The needs for a complete characterization of these candidate materials are identified in terms of high temperature behaviour, radiation damage and coolant compatibility. (author)

  15. Kazakhstan's Environment-Health system, a Big Data challenge

    Science.gov (United States)

    Vitolo, Claudia; Bella Gazdiyeva, Bella; Tucker, Allan; Russell, Andrew; Ali, Maged; Althonayan, Abraham

    2016-04-01

    Kazakhstan has witnessed a remarkable economic development in the past 15 years, becoming an upper-middle-income country. However it is still widely regarded as a developing nation, partially because of its population's low life expectancy which is 5 years below the average in similar economies. The environment is in a rather fragile state, affected by soil, water, air pollution, radioactive contamination and climate change. However, Kazakhstan's government is moving towards clean energy and environmental protection and calling on scientists to help prioritise investments. The British Council-funded "Kazakhstan's Environment-Health Risk Analysis (KEHRA)" project is one of the recently launched initiatives to support Kazakhstan healthier future. The underlying hypothesis of this research is that the above mentioned factors (air/water/soil pollution, etc.) affecting public health almost certainly do not act independently but rather trigger and exacerbate each other. Exploring the environment-health links in a multi-dimensional framework is a typical Big Data problem, in which the volume and variety of the data needed poses technical as well as scientific challenges. In Kazakhstan, the complexities related to managing and analysing Big Data are worsened by a number of obstacles at the data acquisition step: most of the data is not in digital form, spatial and temporal attributes are often ambiguous and the re-use and re-purpose of the information is subject to restrictive licenses and other mechanisms of control. In this work, we document the first steps taken towards building an understanding of the complex environment-health system in Kazakhstan, using interactive visualisation tools to identify and compare hot-spots of pollution and poor health outcomes, Big Data and web technologies to collect, manage and explore available information. In the future, the knowledge acquired will be modelled to develop evidence-based recommendation systems for decision makers in

  16. Challenges for sustainable food systems in metropolitan landscapes

    NARCIS (Netherlands)

    Carsjens, G.J.

    2015-01-01

    Metropolitan landscapes are facing the challenge to find a balance between urban development on the one hand and the preservation of farmland and natural resources on the other. Conventional land use planning approaches are often not up to this complex challenge and many regions are in need for

  17. Environmental decision support systems (EDSS) development - Challenges and best practices

    Science.gov (United States)

    B. S. McIntosh; J. C. Ascough II; S. Chen; J. Chew; S. Cuddy; A. Elmahdi; D. Haase; J. Harou; D. Hepting; A. J. Jakeman; A. Kassahun; S. Lautenbach; K. Matthews; W. Merritt; N. W. T. Quinn; I. Rodriguez-Roda; S. Sieber; M. Stavenga; A. Sulis; J. Ticehurst; M. J. Twery; M. Volk; M. Wrobel; H. van Delden; S. El-Sawah; A. Rizzoli; A. Voinov

    2011-01-01

    Despite the perceived value of DSS in informing environmental and natural resource management, DSS tools often fail to be adopted by intended end users. By drawing together the experience of a global group of EDSS developers, we have identified and assessed key challenges in EDSS development and offer recommendations to resolve them. Challenges related to engaging end...

  18. Challenges of Conversion from Document Management System to Data Management System

    OpenAIRE

    Siali, Irene

    2017-01-01

    Master's thesis in Offshore technology: Industrial asset management Issues that emerged from the use of the document management system and the desire to change to a database management system (DBMS) by many organizations is the driving force behind the ideas from this thesis. Draga AS identified the challenges arising from this shift and provided the basis for this work. The goal is to present a review of the relevant bibliographical material that illustrates those critical factors that bo...

  19. Human Robotic Systems (HRS): Space Robotics Challenge Project

    Data.gov (United States)

    National Aeronautics and Space Administration — During 2013 and 2015, the DARPA Robotics Challenge explored through a competition the tasks and technologies for robots to operate in a natural and man-made...

  20. Enterprise collaboration systems: addressing adoption challenges and the shaping of sociotechnical systems

    Directory of Open Access Journals (Sweden)

    Clara Greeven

    2017-01-01

    Full Text Available This article examines the adoption challenges organizations encounter when they introduce enterprise collaboration systems (ECS and the measures that can be used, i.e. actions that can be taken, to address these challenges. The aim of the article is to provide an overview of the multitude of different ECS adoption challenges and measures, and based on these, to lay the theoretical and analytical basis for studying the shaping of such complex sociotechnical systems. For this purpose, a qualitative meta-analysis of the academic literature and interviews with companies were conducted, which resulted in a collection of ECS challenges and measures classified and analyzed with regard to their specific spatiotemporal aspects. Drawing on the results of this study, research imperatives, which include the call for studying ECS over multiple time frames and settings, are presented. These will be examined in greater depth as part of our wider, multidisciplinary research program that focuses on enterprise collaboration systems use in the emerging digital workplace.

  1. NASA Engineering Design Challenges: Environmental Control and Life Support Systems. Water Filtration Challenge. EG-2008-09-134-MSFC

    Science.gov (United States)

    Schneider, Twila, Ed.

    2010-01-01

    This educator guide is organized into seven chapters: (1) Overview; (2) The Design Challenge; (3) Connections to National Curriculum Standards; (4) Preparing to Teach; (5) Classroom Sessions; (6) Opportunities for Extension; and (7) Teacher Resources. Chapter 1 provides information about Environmental Control and Life Support Systems used on NASA…

  2. The promises and challenges of future reactor system developments

    International Nuclear Information System (INIS)

    Kim, S. H.; Chang, M. H.; Kim, H. J.

    2007-01-01

    improved economy when compared to currently the existing plants. The APR 1400 has been developed since 1991 and it is expected that its first commercial operation will be in 2012. In the short term by 2011, the APR-1400 design will be improved from the viewpoints of safety, economics and performance. We are also developing a small integral reactor SMART, which is a promising advanced small and medium-size power category of nuclear reactors. It is an integral type reactor with a sensible mixture of new innovative design features and proven technologies aimed at achieving a highly enhanced safety and improved economics. SMART is purposed for dual applications such as for seawater desalination and electricity generation. Since the SMART technology is technically sound and has sufficient economics, the SMART desalination plant has good prospects of being deployed as a nuclear desalination plant. We are also actively participating in the GEN IV collaboration (GIF: GEN IV International Forum) for a VHTR and a SFR technology development. Through close collaboration with GIF, a proliferation-resistant SFR technology will be developed based on KALIMAER for an effective uranium utilization and waste minimization. Also a high temperature reactor is currently under development to demonstrate a nuclear based hydrogen production technology. Korea is really looking ahead by developing new generation of advanced nuclear reactor systems for a sustainable development, economical benefits, a clean environment and public confidence. In this paper, Korean nuclear reactor technology development program is described together with lessons learned from self-reliance in nuclear reactor technology. In addition, this paper presents the status of the next generation reactor system development program and the future reactor system development program for addressing these challenges

  3. Building a Global Earth Observation System of Systems (GEOSS) and Its Interoperability Challenges

    Science.gov (United States)

    Ryan, B. J.

    2015-12-01

    Launched in 2005 by industrialized nations, the Group on Earth Observations (GEO) began building the Global Earth Observation System of Systems (GEOSS). Consisting of both a policy framework, and an information infrastructure, GEOSS, was intended to link and/or integrate the multitude of Earth observation systems, primarily operated by its Member Countries and Participating Organizations, so that users could more readily benefit from global information assets for a number of society's key environmental issues. It was recognized that having ready access to observations from multiple systems was a prerequisite for both environmental decision-making, as well as economic development. From the very start, it was also recognized that the shear complexity of the Earth's system cannot be captured by any single observation system, and that a federated, interoperable approach was necessary. While this international effort has met with much success, primarily in advancing broad, open data policies and practices, challenges remain. In 2014 (Geneva, Switzerland) and 2015 (Mexico City, Mexico), Ministers from GEO's Member Countries, including the European Commission, came together to assess progress made during the first decade (2005 to 2015), and approve implementation strategies and mechanisms for the second decade (2016 to 2025), respectively. The approved implementation strategies and mechanisms are intended to advance GEOSS development thereby facilitating the increased uptake of Earth observations for informed decision-making. Clearly there are interoperability challenges that are technological in nature, and several will be discussed in this presentation. There are, however, interoperability challenges that can be better characterized as economic, governmental and/or political in nature, and these will be discussed as well. With the emergence of the Sustainable Development Goals (SDGs), the World Conference on Disaster Risk Reduction (WCDRR), and the United Nations

  4. Data Management Challenges and Development for Military Information Systems

    National Research Council Canada - National Science Library

    Ceruti, Marion G

    2003-01-01

    ..., interoperation, and application of C41 systems. Specific topics include issues in integration and interoperability, joint standards, data access, data aggregation, information system component reuse, and legacy systems...

  5. RNAi nanomedicines: challenges and opportunities within the immune system

    International Nuclear Information System (INIS)

    Weinstein, Shiri; Peer, Dan

    2010-01-01

    RNAi, as a novel therapeutic modality, has an enormous potential to bring the era of personalized medicine one step further from notion into reality. However, delivery of RNAi effector molecules into their target tissues and cells remain extremely challenging. Major attempts have been made in recent years to develop sophisticated nanocarriers that could overcome these hurdles. This review will present the recent progress with the challenges and opportunities in this emerging field, focusing mostly on the in vivo applications with special emphasis on the strategies for RNAi delivery into immune cells. (topical review)

  6. Strategic challenges in neurotherapeutic pharmaceutical development.

    Science.gov (United States)

    Gallen, Christopher C

    2004-01-01

    Developing new therapeutics presents formidable economic, scientific, and medical challenges that are exacerbated by special factors in neurotherapeutics development, e.g., the complexity of the CNS with its attendant need to sometimes affect multiple pathways, the lack of clarity of disease etiology, inadequacy of available animal models, and difficulties in defining disease populations and quantifying treatment response. This paper reviews the economic challenges faced by therapeutics developers in general and neurotherapeutics developers in particular. It discusses key scientific challenges, particularly those pertinent to neurotherapeutics development, as a background to proposing a different industrial strategy to drive future therapeutics development. This Biodesign strategy potentially surpasses previous paradigms by incorporating elements such as the use of disease modeling to select better targets and potential therapies, information science-based approaches to enhance small molecule chemistry, exploitation of the potential for biological technologies to rapidly generate mechanistic probes, and development of improved approaches for using animal models and studying human molecules mechanistically and biologically. Synergistic use of these elements can change the overall business model of companies engaged in neurotherapeutics development. The Biodesign paradigm has the potential to both markedly enhance the development of new therapies and to address some of the economic challenges facing healthcare systems and therapeutics developers alike.

  7. Implementation Challenges of an Enterprise System and Its Advantages over Legacy Systems

    OpenAIRE

    Dr. Nabie Y. Conteh; M. Jalil Akhtar

    2015-01-01

    This paper explores the implementation challenges of Enterprise Resource Planning in the industry and its advantages over legacy systems. The paper depicts the historical background of ERPs and their significance in facilitating coordination among the functional areas of organizations in the industry. It also discusses the role it plays in promoting the activities of Supply Chain Management (SCM) and Customer Relationship Management (CRM). The paper presents empirical data on ERPs and their c...

  8. Future illumination systems and the climate change challenge

    DEFF Research Database (Denmark)

    Bjarklev, Araceli; Bjarklev, Anders Overgaard

    2010-01-01

    are met in conjunction with situations, where the esthetical design issues are addressed. Finally, our study also points out to the necessity of finding a trans-disciplinary cooperation across sectors to more effectively answer to the climate change challenge, when designing low-carbon technologies...

  9. Farming Systems and the Challenge of Climate Change

    African Journals Online (AJOL)

    ... of the damages that it brings to the environment, local people would have to be educated en masse on the issues at stake with which they are little aware of and initiatives in the agricultural sector integrated in all other initiatives geared at meeting the climate change challenge. Keywords: Knowledge, practices, agriculture, ...

  10. Environmental decision support systems (EDSS) development - Challenges and best practices

    NARCIS (Netherlands)

    McIntosh, B.S.; Ascough, J.C.; Twery, M.; Chew, J.; Elmahdi, A.; Haase, D.; Harou, J.J.; Hepting, D.; Cuddy, S.; Jakeman, A.J.; Chen, S.; Kassahun, A.; Lautenbach, S.; Matthews, K.; Merritt, W.; Quinn, N.W.T.; Rodriguez-Roda, I.; Sieber, S.; Stavenga, M.; Sulis, A.; Ticehurst, J.; Volk, M.; Wrobel, M.; Delden, H.; El-Sawah, S.; Rizzoli, A.; Voinov, A.

    2011-01-01

    Despite the perceived value of DSS in informing environmental and natural resource management, DSS tools often fail to be adopted by intended end users. By drawing together the experience of a global group of EDSS developers, we have identified and assessed key challenges in EDSS development and

  11. Teacher Perspectives of Challenges within the Norwegian Educational System

    Science.gov (United States)

    Anderson, Sarah K.; Terras, Katherine L.

    2015-01-01

    This research examines teacher perspectives' of educational challenges in Norway. Norway is one of the most well-resourced, prosperous, social welfare states in the world, yet the OECD (2011) recognized students' weak basic skills and insufficient teacher ability in content and pedagogy, along with engagement and imbalanced resources as points for…

  12. The Forgotten Tribe in ODL Systems: Challenges Faced by Visually ...

    African Journals Online (AJOL)

    This study sought to evaluate the challenges faced by visually impaired students in Open and Distance Learning (ODL) Institutions of Higher Learning. This was a case study of the Zimbabwe Open University. Twenty purposefully selected lecturers in the Faculty of Applied Social Sciences and ten blind and visually impaired ...

  13. The challenge of benchmarking health systems: is ICT innovation capacity more systemic than organizational dependent?

    Science.gov (United States)

    Lapão, Luís Velez

    2015-01-01

    The article by Catan et al. presents a benchmarking exercise comparing Israel and Portugal on the implementation of Information and Communication Technologies in the healthcare sector. Special attention was given to e-Health and m-Health. The authors collected information via a set of interviews with key stakeholders. They compared two different cultures and societies, which have reached slightly different implementation outcomes. Although the comparison is very enlightening, it is also challenging. Benchmarking exercises present a set of challenges, such as the choice of methodologies and the assessment of the impact on organizational strategy. Precise benchmarking methodology is a valid tool for eliciting information about alternatives for improving health systems. However, many beneficial interventions, which benchmark as effective, fail to translate into meaningful healthcare outcomes across contexts. There is a relationship between results and the innovational and competitive environments. Differences in healthcare governance and financing models are well known; but little is known about their impact on Information and Communication Technology implementation. The article by Catan et al. provides interesting clues about this issue. Public systems (such as those of Portugal, UK, Sweden, Spain, etc.) present specific advantages and disadvantages concerning Information and Communication Technology development and implementation. Meanwhile, private systems based fundamentally on insurance packages, (such as Israel, Germany, Netherlands or USA) present a different set of advantages and disadvantages - especially a more open context for innovation. Challenging issues from both the Portuguese and Israeli cases will be addressed. Clearly, more research is needed on both benchmarking methodologies and on ICT implementation strategies.

  14. Progress and challenges to the global waste management system

    OpenAIRE

    Singh, J; Laurenti, R; Sinha, R; Frostell, B

    2014-01-01

    Rapid economic growth, urbanization and increasing population have caused (materially intensive) resource consumption to increase, and consequently the release of large amounts of waste to the environment. From a global perspective, current waste and resource management lacks a holistic approach covering the whole chain of product design, raw material extraction, production, consumption, recycling and waste management. In this article, progress and different sustainability challenges facing t...

  15. Methodological challenges of trans-disciplinary research: Some systemic reflections

    OpenAIRE

    Ison, Ray

    2008-01-01

    This essay was written in response to an invitation by the editors of NSS issued after the author had reviewed the paper entitled 'Methodological challenges of trans-disciplinary research' submitted by Christian Pohl and Gertrude Hirsch-Hadorn (see Pohl and Hirsch Hadorn, 2008). The essay provides an accounting for the transformation in my emotioning as I read the submitted paper by introducing three sets of distinctions: (i) a model of research practice; (ii) an explication of the nature of ...

  16. Taming Big Data Variety in the Earth Observing System Data and Information System

    Science.gov (United States)

    Lynnes, Christopher; Walter, Jeff

    2015-01-01

    Although the volume of the remote sensing data managed by the Earth Observing System Data and Information System is formidable, an oft-overlooked challenge is the variety of data. The diversity in satellite instruments, science disciplines and user communities drives cost as much or more as the data volume. Several strategies are used to tame this variety: data allocation to distinct centers of expertise; a common metadata repository for discovery, data format standards and conventions; and services that further abstract the variations in data.

  17. Challenges of information systems strategy implementation in public hospitals: a South African experience

    CSIR Research Space (South Africa)

    Hwabamungu, B

    2015-05-01

    Full Text Available Information Systems (IS) strategizing research conducted mostly in the private sector setting indicates that there are many challenges to the implementation of Information Systems strategy and that there is need for further research...

  18. The Modern Hearing Aid – an Extreme System Integration Challenge

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    of the ICs for these. This leads to very large demands for system integration at the packing level, SiP (System-in-Package), and not at least at the IC level, SoC (System-on-Chip). As a result of this all large hearing aid manufactures use custom package technology which again uses fully customized ASICs...

  19. Arctic System Science: Meeting Earth System and Social Impact Challenges through Integrative Approaches and Synthesis

    Science.gov (United States)

    Vorosmarty, C. J.; Hinzman, L. D.; Rawlins, M. A.; Serreze, M. C.; Francis, J. A.; Liljedahl, A. K.; McDonald, K. C.; Piasecki, M.; Rich, R. H.; Holland, M. M.

    2017-12-01

    The Arctic is an integral part of the Earth system where multiple interactions unite its natural and human elements. Recent observations show the Arctic to be experiencing rapid and amplified signatures of global climate change. At the same time, the Arctic system's response to this broader forcing has itself become a central research topic, given its potential role as a critical throttle on future planetary dynamics. Changes are already impacting life systems and economic prosperity and continued change is expected to bear major implications far outside the region. We also have entered an era when environmental management, traditionally local in scope, must confront regional, whole biome, and pan-Arctic biogeophysical challenges. While challenges may appear to operate in isolation, they emerge within the context of an evolving, integrated Arctic system defined by interactions among natural and social sub-systems. Clearly, new efforts aimed at community planning, industrial development, and infrastructure construction must consider this multiplicity of interacting processes. We recently organized an "Arctic System Synthesis Workshop Series" supported by the Arctic Systems Science Program of NSF and devoted to exploring approaches capable of uncovering the systems-level behavior in both the natural and social sciences domains. The series featured two topical meetings. The first identified the sources responsible for extreme climate events in the Arctic. The second focused on multiple "currencies" within the system (i.e., water, energy, carbon, nutrients) and how they interact to produce systems-level behaviors. More than 40 experts participated, drawn from the ranks of Arctic natural and social sciences. We report here on the workshop series consensus report, which identifies a broad array of topics. Principal among these are a consideration of why study the Arctic as a system, as well as an articulation of the major systems-level approaches to support basic as well

  20. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system

    Science.gov (United States)

    Kihuba, Elesban; Gheorghe, Adrian; Bozzani, Fiammetta; English, Mike; Griffiths, Ulla K.

    2016-01-01

    Background Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. Design We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit) framework to analyze the components and standards of a cost accounting system. Results Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. Conclusion To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context. PMID:27357072

  1. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system

    Directory of Open Access Journals (Sweden)

    Elesban Kihuba

    2016-06-01

    Full Text Available Background: Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. Design: We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit framework to analyze the components and standards of a cost accounting system. Results: Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. Conclusion: To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context.

  2. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system.

    Science.gov (United States)

    Kihuba, Elesban; Gheorghe, Adrian; Bozzani, Fiammetta; English, Mike; Griffiths, Ulla K

    2016-01-01

    Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit) framework to analyze the components and standards of a cost accounting system. Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context.

  3. Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS Drug Delivery Systems for in Vitro and in Vivo Applications

    Directory of Open Access Journals (Sweden)

    Ken-Tye Yong

    2012-11-01

    Full Text Available Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

  4. Big Data challenges and solutions in building the Global Earth Observation System of Systems (GEOSS)

    Science.gov (United States)

    Mazzetti, Paolo; Nativi, Stefano; Santoro, Mattia; Boldrini, Enrico

    2014-05-01

    The Group on Earth Observation (GEO) is a voluntary partnership of governments and international organizations launched in response to calls for action by the 2002 World Summit on Sustainable Development and by the G8 (Group of Eight) leading industrialized countries. These high-level meetings recognized that international collaboration is essential for exploiting the growing potential of Earth observations to support decision making in an increasingly complex and environmentally stressed world. To this aim is constructing the Global Earth Observation System of Systems (GEOSS) on the basis of a 10-Year Implementation Plan for the period 2005 to 2015 when it will become operational. As a large-scale integrated system handling large datasets as those provided by Earth Observation, GEOSS needs to face several challenges related to big data handling and big data infrastructures management. Referring to the traditional multiple Vs characteristics of Big Data (volume, variety, velocity, veracity and visualization) it is evident how most of them can be found in data handled by GEOSS. In particular, concerning Volume, Earth Observation already generates a large amount of data which can be estimated in the range of Petabytes (1015 bytes), with Exabytes (1018) already targeted. Moreover, the challenge is related not only to the data size, but also to the large amount of datasets (not necessarily having a big size) that systems need to manage. Variety is the other main challenge since datasets coming from different sensors, processed for different use-cases are published with highly heterogeneous metadata and data models, through different service interfaces. Innovative multidisciplinary applications need to access and use those datasets in a harmonized way. Moreover Earth Observation data are growing in size and variety at an exceptionally fast rate and new technologies and applications, including crowdsourcing, will even increase data volume and variety in the next future

  5. Adaptive Embedded SystemsChallenges of Run-Time Resource Management

    DEFF Research Database (Denmark)

    Understanding and efficiently controlling the dynamic behavior of adaptive embedded systems is a challenging endavor. The challenges come from the often very complicated interplay between the application, the application mapping, and the underlying hardware architecture. With MPSoC, we have...... the technology to design and fabricate dynamically reconfigurable hardware platforms. However, such platforms will pose new challenges to tools and methods to efficiently explore these platforms at run-time. This talk will address some of the challenges of run-time resource management in adaptive embedded...... systems....

  6. Power System Challenge: Synthesis Report for the 7th Clean Energy Ministerial

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-06-01

    The Clean Energy Ministerial's (CEM's) Power System Challenge was established in 2015 to create a shared vision among major economies regarding the pathway to clean, reliable, resilient, and affordable power. Endorsing governments have created core principles and challenge propositions as a framework for government and industry action to support and guide power system transformation. This brochure details the status of the Challenge, how countries are working to meet the Challenge, and the relevant milestones reached by initiatives of the Clean Energy Ministerial.

  7. Emerging nuclear energy systems: Economic challenge: Revision 1

    International Nuclear Information System (INIS)

    Nuckolls, J.H.

    1986-01-01

    Future nuclear energy systems may achieve substantially lower energy costs than those of existing fossil energy systems and comparable capital costs. Such low cost nuclear energy would provide a strong economic incentive to minimize the use of fossil fuels. If these low cost nuclear energy systems emerge in the next few decades, 21st century civilization may be able to avert potentially disastrous CO 2 induced global climate changes. 12 refs., 1 fig

  8. The emergence of enterprise systems management: a challenge to the IS curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2006-01-01

    This paper proposes four cornerstones of a future Information Systems (IS) curriculum. It analyses the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage...... resulting in the emergence of Enterprise Systems Management (ESM). ESM calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways of approaching...... the challenges...

  9. Challenging obduracy : How local communities transform the energy system

    NARCIS (Netherlands)

    Van Der Schoor, Tineke; Van Lente, Harro; Scholtens, Bert; Peine, Alex

    2016-01-01

    The transformation from the current energy system to a decentralized renewable energy system requires the transformation of communities into energy neutral or even energy producing communities. Increasingly, citizens become 'prosumers' and pool their resources to start a local energy initiative. In

  10. Hidden Challenges to Education Systems in Transition Economies.

    Science.gov (United States)

    Berryman, Sue E.

    This book, published by the World Bank, sounds the alarm for education in Europe and Central Asia (ECA). It describes how the transition from communism to free-market economies has left many countries' educational systems in disarray. At the start of transition, ECA education systems had solved problems that plagued other regions of the world,…

  11. Global positioning system : challenges in sustaining and upgrading capabilities persist.

    Science.gov (United States)

    2010-09-01

    The Global Positioning System (GPS) provides positioning, navigation, and timing (PNT) data to users worldwide. The U.S. Air Force, which is responsible for GPS acquisition, is in the process of modernizing the system. Last year GAO reported that it ...

  12. Accelerating cooperative systems' development through the Grand Cooperative Driving challenge

    NARCIS (Netherlands)

    Vonk Noordegraaf, D.; Malone, K.M.; Katwijk, R. van; Gerrits, A.

    2009-01-01

    Cooperative driving systems comprise an important research area. They are considered a promising solution for reducing traffic congestion, reducing environmental impact and improving traffic safety and driver comfort. The key to these systems is the communication and interaction between vehicles and

  13. ENVIRONMENTAL SYSTEMS MANAGEMENT, SUSTAINABILITY THEORY, AND THE CHALLENGE OF UNCERTAINTY

    Science.gov (United States)

    Environmental Systems Management is the management of environmental problems at the systems level fully accounting fo rthe multi-dimensional nature of the environment. This includes socio-economic dimensions as well s the usual physical and life science aspects. This is important...

  14. An integrated drug prescription and distribution system: challenges and opportunities.

    Science.gov (United States)

    Lanssiers, R; Everaert, E; De Win, M; Van De Velde, R; De Clercq, H

    2002-01-01

    Using the hospital's drug prescription and distribution system as a guide, benefits and drawbacks of a medical activity management system that is tightly integrated with the supply chain management of a hospital will be discussed from the point of view of various participating healthcare actors.

  15. Child human trafficking victims: challenges for the child welfare system.

    Science.gov (United States)

    Fong, Rowena; Berger Cardoso, Jodi

    2010-08-01

    Since the passing of the Victims of Trafficking and Violence Protection Act in 2000 and its reauthorization by President George Bush in 2008, federal, state and community efforts in identifying and providing services for victims of human trafficking have significantly improved. However, most of the research and resources for trafficking victims have been directed towards adults rather than children. Researchers agree that there is a growing number of sexually exploited and trafficked children in the United States yet few programs emphasize the unique experiences and special needs of this population. This article examines commercial sexual exploitation of children; differentiates the needs and problems between child prostitution and victims of human trafficking; reviews and critiques current treatment practices; and summarizes challenges and successes in working with child victims of human trafficking, offering practice and policy recommendations. Published by Elsevier Ltd.

  16. Challenges of Forecasting Physician Workforce Needs Amid Delivery System Transformation.

    Science.gov (United States)

    Cunningham, Rob

    2015-09-29

    As population growth and the aging of the overall population increase demand for health care, policymakers and analysts grapple with whether sufficient health care providers, particularly physicians, will be available to meet that demand. Some argue there are too few physicians already; others say our current supply-demand problems lie with efficiency. But suppose both are correct? Perhaps the real challenge is to understand how the provision of health care services is changing in response to market forces such as payment changes, patients' expectations, provider distributions, and technology innovations. This issue brief revisits what is known about evolving practice organizations, professional mixes, information technology support, and the implications of these and other factors for physician workforce policies.

  17. Green certificate system for heating - principal and practical challenges

    International Nuclear Information System (INIS)

    Eldegard, Tom

    2002-01-01

    A certificate system with an obligation to buying is a very relevant instrument in energy policy in order to stimulate the implementation of new renewable energy sources. This solution is widely supported; it is being institutionalized in many countries, especially in Europe and in the electricity sector, and the heating sector is soon to follow. This report discusses the broad lines of a possible green certificate system for the heating sector in Norway and concludes that it is might well be linked with a similar system for the electricity sector. For Norway, an isolated certificate system for the electricity sector would not be cost-effective. This is because this system would emphasize relatively expensive renewable electric energy rather than utilizing the large potential for replacing the electric heating of buildings with much cheaper renewable heat

  18. Decadel climate prediction: challenges and opportunities

    International Nuclear Information System (INIS)

    Hurrell, J W

    2008-01-01

    The scientific understanding of climate change is now sufficiently clear to show that climate change from global warming is already upon us, and the rate of change as projected exceeds anything seen in nature in the past 10,000 years. Uncertainties remain, however, especially regarding how climate will change at regional and local scales where the signal of natural variability is large. Addressing many of these uncertainties will require a movement toward high resolution climate system predictions, with a blurring of the distinction between shorter-term predictions and longer-term climate projections. The key is the realization that climate system predictions, regardless of timescale, will require initialization of coupled general circulation models with best estimates of the current observed state of the atmosphere, oceans, cryosphere, and land surface. Formidable challenges exist: for instance, what is the best method of initialization given imperfect observations and systematic errors in models? What effect does initialization have on climate predictions? What predictions should be attempted, and how would they be verified? Despite such challenges, the unrealized predictability that resides in slowly evolving phenomena, such as ocean current systems, is of paramount importance for society to plan and adapt for the next few decades. Moreover, initialized climate predictions will require stronger collaboration with shared knowledge, infrastructure and technical capabilities among those in the weather and climate prediction communities. The potential benefits include improved understanding and predictions on all time scales

  19. Application and Development of Energy System Optimisation Models to Meet Challenges of the Future

    DEFF Research Database (Denmark)

    Balyk, Olexandr

    Climate change, security of supply and local air pollution are among the challenges that are shaping the future of energy systems worldwide. In response to these challenges, various goals are set nationally and internationally that energy systems are supposed to fulfil. These include e.g. EU 20...... them. The challenges of climate change, security of supply, and local air pollution are addressed in the papers by focusing on renewable energy systems, demand side management options, climate change mitigation and resource potentials. In the process of the study the energy system optimisation models...... upon in the Copenhagen Accord and the importance of large emerging economies in this context, and the role of district heating in the future Danish renewable energy system.The outcomes of this work illustrate the potential of energy system optimisation models to address challenges of the future...

  20. Development of tsunami early warning systems and future challenges

    Directory of Open Access Journals (Sweden)

    J. Wächter

    2012-06-01

    Full Text Available Fostered by and embedded in the general development of information and communications technology (ICT, the evolution of tsunami warning systems (TWS shows a significant development from seismic-centred to multi-sensor system architectures using additional sensors (e.g. tide gauges and buoys for the detection of tsunami waves in the ocean.

    Currently, the beginning implementation of regional tsunami warning infrastructures indicates a new phase in the development of TWS. A new generation of TWS should not only be able to realise multi-sensor monitoring for tsunami detection. Moreover, these systems have to be capable to form a collaborative communication infrastructure of distributed tsunami warning systems in order to implement regional, ocean-wide monitoring and warning strategies.

    In the context of the development of the German Indonesian Tsunami Early Warning System (GITEWS and in the EU-funded FP6 project Distant Early Warning System (DEWS, a service platform for both sensor integration and warning dissemination has been newly developed and demonstrated. In particular, standards of the Open Geospatial Consortium (OGC and the Organization for the Advancement of Structured Information Standards (OASIS have been successfully incorporated.

    In the FP7 project Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC, new developments in ICT (e.g. complex event processing (CEP and event-driven architecture (EDA are used to extend the existing platform to realise a component-based technology framework for building distributed tsunami warning systems.

  1. The LHCb Silicon Tracker - Control system specific tools and challenges

    CERN Document Server

    Adeva, G; Gallas, A; Pazos Alvarez, A; Perez Trigo, E; Rodriguez Perez, P; Saborido, J; Amhis, Y; Bay, A; Blanc, F; Bressieux, J; Conti, G; Dupertuis, F; Fave, V; Frei, R; Gauvin, N; Haefeli, G; Keune, A; Luisier, J; Marki, R; Muresan, R; Nakada, T; Needham, M; Knecht, M; Schneider, O; Tran, M; Anderson, J; Buechler, A; Bursche, A; Chiapolini, N; De Cian, M; Elsasser, C; Salzmann, C; Saornil Gamarra, S; Steiner, S; Steinkamp, O; Straumann, U; van Tilburg, J; Tobin, M; Vollhardt, A; Aquines Gutierrez, O; Bauer, C; Britsch, M; Maciuc, F; Schmelling, M; Voss, H; Iakovenko, V; Okhrimenko, O; Pugatch, V

    2014-01-01

    The Experiment Control System (ECS) of the LHCb Silicon Tracker sub-detectors is built on the integrated LHCb ECS framework. Although all LHCb sub-detectors use the same framework and follow the same guidelines, the Silicon Tracker control system uses some interesting additional features in terms of operation and monitoring. The main details are described in this document. Since its design, the Silicon Tracker control system has been continuously evolving in a quite disorganized way. Some major maintenance activities are required to be able to keep improving. A description of those activities can also be found here.

  2. The challenges of developing a trauma system for Indigenous people.

    Science.gov (United States)

    Plani, Frank; Carson, Phil

    2008-12-01

    Trauma systems have been shown to provide the best trauma care for injured patients. A trauma system developed for Indigenous people should take into account many factors including geographical remoteness and cultural diversity. Indigenous people suffer from a significant intentional and non-intentional burden of injury, often greater than non-Indigenous populations, and a public health approach in dealing with trauma can be adopted. This includes transport issues, prevention and control of intentional violence, cultural sensitization of health providers, community emergency responses, community rehabilitation and improving resilience. The ultimate aim is to decrease the trauma burden through a trauma system with which indigenous people can fully identify.

  3. Psychedelic Drugs as Therapeutics: No Illusions About the Challenges.

    Science.gov (United States)

    Sellers, Edward M; Leiderman, Deborah B

    2018-04-01

    Interest in the potential therapeutic benefits of psychedelic agents has recently increased. In addition to psilocybin, a wide variety of agents with psychedelic properties have been proposed and partially tested. However, the challenges of obtaining approval to market a restricted psychotomimetic agent are formidable. © 2017 American Society for Clinical Pharmacology and Therapeutics.

  4. Systemic inflammatory responses following welding inhalation challenge test

    Directory of Open Access Journals (Sweden)

    Paula Kauppi

    2015-01-01

    Conclusions: Exposure to MS and SS welding fume resulted in a mild systemic inflammatory response. The particle concentration from the breathing zones correlated with the measurements inside the welding face shields.

  5. Information System as a Service: Issues and Challenges

    OpenAIRE

    Hilman, Muhammad

    2013-01-01

    Information system evolved as the evolution of information technology. The current state of information technology, placed the internet as a main resources of computing. Cloud technology as the backbone of internet has been utilized as a powerful computing resources. Therefore, cloud introduced new term of service oriented technology, popular with "as a service" kind of name. In this paper, the service oriented paradigm will be used to address future trend of information system. Thus, this pa...

  6. H4: A challenging system for natural orbital functional approximations

    International Nuclear Information System (INIS)

    Ramos-Cordoba, Eloy; Lopez, Xabier; Piris, Mario; Matito, Eduard

    2015-01-01

    The correct description of nondynamic correlation by electronic structure methods not belonging to the multireference family is a challenging issue. The transition of D 2h to D 4h symmetry in H 4 molecule is among the most simple archetypal examples to illustrate the consequences of missing nondynamic correlation effects. The resurgence of interest in density matrix functional methods has brought several new methods including the family of Piris Natural Orbital Functionals (PNOF). In this work, we compare PNOF5 and PNOF6, which include nondynamic electron correlation effects to some extent, with other standard ab initio methods in the H 4 D 4h /D 2h potential energy surface (PES). Thus far, the wrongful behavior of single-reference methods at the D 2h –D 4h transition of H 4 has been attributed to wrong account of nondynamic correlation effects, whereas in geminal-based approaches, it has been assigned to a wrong coupling of spins and the localized nature of the orbitals. We will show that actually interpair nondynamic correlation is the key to a cusp-free qualitatively correct description of H 4 PES. By introducing interpair nondynamic correlation, PNOF6 is shown to avoid cusps and provide the correct smooth PES features at distances close to the equilibrium, total and local spin properties along with the correct electron delocalization, as reflected by natural orbitals and multicenter delocalization indices

  7. Challenges and Opportunities of Implementing District-based Health Information System in Ethiopia

    DEFF Research Database (Denmark)

    Mengiste, Shegaw Anagaw

    2005-01-01

    This paper has analyzed the challenges of sustainability and scalability of HIS. The empirical analysis was conducted in a backward and disadvantaged region of Ethiopia. An ongoing process of HISP (Health Information System Program) was addressed and the main challenges in the implementation...... of sustainable and scalable district-based health information system in the context of Primary Health Care (PHC) sector in Ethiopia were identified. Human resource, infrastructure, and HIS related problems are the main challenges hindering the implementation of sustainable and scalable district-based health...... information systems in the region....

  8. Computational Research Challenges and Opportunities for the Optimization of Fossil Energy Power Generation System

    Energy Technology Data Exchange (ETDEWEB)

    Zitney, S.E.

    2007-06-01

    Emerging fossil energy power generation systems must operate with unprecedented efficiency and near-zero emissions, while optimizing profitably amid cost fluctuations for raw materials, finished products, and energy. To help address these challenges, the fossil energy industry will have to rely increasingly on the use advanced computational tools for modeling and simulating complex process systems. In this paper, we present the computational research challenges and opportunities for the optimization of fossil energy power generation systems across the plant lifecycle from process synthesis and design to plant operations. We also look beyond the plant gates to discuss research challenges and opportunities for enterprise-wide optimization, including planning, scheduling, and supply chain technologies.

  9. Web Content Management Systems: An Analysis of Forensic Investigatory Challenges.

    Science.gov (United States)

    Horsman, Graeme

    2018-02-26

    With an increase in the creation and maintenance of personal websites, web content management systems are now frequently utilized. Such systems offer a low cost and simple solution for those seeking to develop an online presence, and subsequently, a platform from which reported defamatory content, abuse, and copyright infringement has been witnessed. This article provides an introductory forensic analysis of the three current most popular web content management systems available, WordPress, Drupal, and Joomla! Test platforms have been created, and their site structures have been examined to provide guidance for forensic practitioners facing investigations of this type. Result's document available metadata for establishing site ownership, user interactions, and stored content following analysis of artifacts including Wordpress's wp_users, and wp_comments tables, Drupal's "watchdog" records, and Joomla!'s _users, and _content tables. Finally, investigatory limitations documenting the difficulties of investigating WCMS usage are noted, and analysis recommendations are offered. © 2018 American Academy of Forensic Sciences.

  10. European coding system for tissues and cells: a challenge unmet?

    Science.gov (United States)

    Reynolds, Melvin; Warwick, Ruth M; Poniatowski, Stefan; Trias, Esteve

    2010-11-01

    The Comité Européen de Normalisation (European Committee for Standardization, CEN) Workshop on Coding of Information and Traceability of Human Tissues and Cells was established by the Expert Working Group of the Directorate General for Health and Consumer Affairs of the European Commission (DG SANCO) to identify requirements concerning the coding of information and the traceability of human tissues and cells, and propose guidelines and recommendations to permit the implementation of the European Coding system required by the European Tissues and Cells Directive 2004/23/EC (ED). The Workshop included over 70 voluntary participants from tissue, blood and eye banks, national ministries for healthcare, transplant organisations, universities and coding organisations; mainly from Europe with a small number of representatives from professionals in Canada, Australia, USA and Japan. The Workshop commenced in April 2007 and held its final meeting in February 2008. The draft Workshop Agreement went through a public comment phase from 15 December 2007 until 15 January 2008 and the endorsement period ran from 9 April 2008 until 2 May 2008. The endorsed CEN Workshop Agreement (CWA) set out the issues regarding a common coding system, qualitatively assessed what the industry felt was required of a coding system, reviewed coding systems that were put forward as potential European coding systems and established a basic specification for a proposed European coding system for human tissues and cells, based on ISBT 128, and which is compatible with existing systems of donation identification, traceability and nomenclatures, indicating how implementation of that system could be approached. The CWA, and the associated Workshop proposals with recommendations, were finally submitted to the European Commission and to the Committee of Member States that assists its management process under article 29 of the Directive 2004/23/EC on May 25 2008. In 2009 the European Commission initiated an

  11. Road transportation challenges and systems for the next decade

    International Nuclear Information System (INIS)

    Welbourne, E.R.

    1992-01-01

    An overview is presented of the historical evolution in road transport systems technology and regulations, and of developments foreseen in the next decade, in the contexts of safety, energy consumption and emissions, and the environment. Collision reduction technology including high centre mounted stop lights, antilock braking systems, headlight glare reduction, crashworthiness, and impact modes are discussed. Technology for reducing energy consumption, global climate change implications, chlorofluorocarbons, urban air quality impacts, and the conflict between improved safety and the environment (larger cars tend to be safer) are discussed. 13 refs

  12. Security challenges for cooperative and interconnected mobility systems

    NARCIS (Netherlands)

    Bijlsma, T.; Kievit, S. de; Sluis, H.J.D. van de; Nunen, E. van; Passchier, I.; Luiijf, H.A.M.

    2013-01-01

    Software is becoming an important part of the innovation for vehicles. In addition, the systems in vehicles become interconnected and also get external connections, to the internet and Vehicular Ad hoc NETworks (VANETs). These trends form a combined security and safety threat, because recent

  13. Climate benefits and environmental challenges related to urban food systems

    NARCIS (Netherlands)

    Verzandvoort, S.J.E.; Mol, G.; Meulen, van der Suzanne; Oostrom, van Niels

    2014-01-01

    In a short literature review, we have collected available knowledge on the potential benefits of urban agriculture, as part of local food systems, on climate change mitigation and adaptation. The effects of urban agriculture on climate change mitigation and adaptation depend on the type of

  14. Independent School Success Challenging the Danish Public School System

    Science.gov (United States)

    Ringsmose, Charlotte

    2013-01-01

    Denmark has had a long history of placing a high priority on education and public schooling. It is a declared goal of the Danish welfare system to provide comprehensive schooling, where children from different socioeconomic backgrounds can go to school together and have the same opportunities through education. It is also a declared goal for…

  15. Predictive maintenance of maritime systems : models and challenges

    NARCIS (Netherlands)

    Tinga, T.; Tiddens, W.W.; Amoiralis, F.; Politis, M.; Cepin, Marko; Bris, Radim

    2017-01-01

    To reduce maintenance and logistic costs and increase the asset availability, a predictive maintenance concept for maritime systems is developed. In the present paper, the physics-of-failure based prognostic methods will be introduced, but also other issues related to the development and application

  16. Inclusive Education as Complex Process and Challenge for School System

    Science.gov (United States)

    Al-Khamisy, Danuta

    2015-01-01

    Education may be considered as a number of processes, actions and effects affecting human being, as the state or level of the results of these processes or as the modification of the functions, institutions and social practices roles, which in the result of inclusion become new, integrated system. Thus this is very complex process. Nowadays the…

  17. Opportunities and Challenges of Multi-Loop Aquaponic Systems

    NARCIS (Netherlands)

    Goddek, Simon

    2017-01-01

    Climate change requires new and innovative agricultural approaches to food security, especially in countries facing water scarcity. In this context, aquaponics could constitute a partial solution to tackle this issue. Traditional designs for one-loop aquaponic systems comprise of both aquaculture

  18. Participatory Design and the Challenges of Large-Scale Systems

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2008-01-01

    With its 10th biannual anniversary conference, Participatory Design (PD) is leaving its teens and must now be considered ready to join the adult world. In this article we encourage the PD community to think big: PD should engage in large-scale information-systems development and opt for a PD...

  19. Opportunities and Challenges of Multi-Loop Aquaponic Systems

    NARCIS (Netherlands)

    Goddek, Simon

    2017-01-01

    Climate change requires new and innovative agricultural approaches to food security, especially in countries facing water scarcity. In this context, aquaponics could constitute a partial solution to tackle this issue. Traditional designs for one-loop aquaponic systems comprise of both aquaculture

  20. Reforms and Challenges of Post-conflict Kosovo Health System.

    Science.gov (United States)

    Mustafa, Mybera; Berisha, Merita; Lenjani, Basri

    2014-04-01

    Before its collapse, Kosovo's healthcare system was an integrated part of the Former Yugoslav Republics System (known as relatively well advanced for its time). Standstill had begun in the last decade of the twentieth century as the result of political disintegration of the former state. The enthusiasm of the healthcare professionals and the people of Kosovo that at the end of the conflict healthcare services will consolidate did not prove just right. Although we can claim that reorganization of Kosovo healthcare was a serious push (especially in the first years after the conflict), the intensity of development begun to fall at the latter stages. Although the basic legislation for the operation of the Healthcare System today in Kosovo does exist, the largest cause for the reform stagnation is where the law is not implemented properly and measures are not set as to a meaningful system of accountability. Twelve years have passed by since the 1999 war-conflict and, although, Kosovo has made progress in many other spheres, it has not yet reached to consolidate a health system comparable to those of other European countries. Intending to get out of difficult situation, several healthcare strategic plans have been developed in the past decade in Kosovo, but attempts in this direction have not been particularly fruitful. This script describes the actual Healthcare complexity of a situation in Kosovo 12 years after the end of the 1999 war-conflict. Interconnection and historical background is also looked upon and is described in the flow of events. Finally, the description of transfer competencies from international administrators to the local authorities as well as the flow of strategic planning that took place since 1999 has also been analyzed.

  1. Towards An Oceanographic Component Of A Global Earth Observation System Of Systems: Progress And Challenges

    Science.gov (United States)

    Ackleson, S. G.

    2012-12-01

    Ocean observatories (systems of coordinated sensors and platforms providing real-time in situ observations across multiple temporal and spatial scales) have advanced rapidly during the past several decades with the integration of novel hardware, development of advanced cyber-infrastructures and data management software, and the formation of researcher networks employing fixed, drifting, and mobile assets. These advances have provided persistent, real-time, multi-disciplinary observations representing even the most extreme environmental conditions, enabled unique and informative views of complicated ocean processes, and aided in the development of more accurate and higher fidelity ocean models. Combined with traditional ship-based and remotely sensed observations, ocean observatories have yielded new knowledge across a broad spectrum of earth-ocean scales that would likely not exist otherwise. These developments come at a critical time in human history when the demands of global population growth are creating unprecedented societal challenges associated with rapid climatic change and unsustainable consumption of key ocean resources. Successfully meeting and overcoming these challenges and avoiding the ultimate tragedy of the commons will require greater knowledge of environmental processes than currently exists, including interactions between the ocean, the overlying atmosphere, and the adjacent land and synthesizing new knowledge into effective policy and management structures. To achieve this, researchers must have free and ready access to comprehensive data streams (oceanic, atmospheric, and terrestrial), regardless of location and collection system. While the precedent for the concept of free and open access to environmental data is not new (it traces back to the International Geophysical Year, 1957), implementing procedures and standards on a global scale is proving to be difficult, both logistically and politically. Observatories have been implemented in many

  2. Mars Surface System Common Capabilities and Challenges for Human Missions

    Science.gov (United States)

    Hoffman, Stephen J.; Toups, Larry

    2016-01-01

    NASA has begun a process to identify and evaluate candidate locations where humans could land, live and work on the martian surface. These locations are referred to as Exploration Zones (EZs). Given current mission concepts, an EZ is a collection of Regions of Interest (ROIs) that are located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains a landing site and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. In parallel with this process, NASA continues to make progress on the Evolvable Mars Campaign examining alternatives that can pioneer an extended human presence on Mars that is Earth independent. This involves ongoing assessments of surface systems and operations to enable a permanent, sustainable human presence. Because of the difficulty in getting equipment and supplies to the surface of Mars, part of these assessments involve identifying those systems and processes that can perform in multiple, sometimes completely unrelated, situations. These assessments have been performed in a very generic surface mission carried out at a very generic surface location. As specific candidate EZs are identified it becomes important to evaluate the current suite of surface systems and operations as they are likely to perform for the specific locations and for the types of operations - both scientific and development - that are proposed for these EZs. It is also important to evaluate the proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. This means looking at setting up and operating a field station at a central location within the EZ as well as traversing to and

  3. Developing and using expert systems and neural networks in medicine: a review on benefits and challenges.

    Science.gov (United States)

    Sheikhtaheri, Abbas; Sadoughi, Farahnaz; Hashemi Dehaghi, Zahra

    2014-09-01

    Complicacy of clinical decisions justifies utilization of information systems such as artificial intelligence (e.g. expert systems and neural networks) to achieve better decisions, however, application of these systems in the medical domain faces some challenges. We aimed at to review the applications of these systems in the medical domain and discuss about such challenges. Following a brief introduction of expert systems and neural networks by representing few examples, the challenges of these systems in the medical domain are discussed. We found that the applications of expert systems and artificial neural networks have been increased in the medical domain. These systems have shown many advantages such as utilization of experts' knowledge, gaining rare knowledge, more time for assessment of the decision, more consistent decisions, and shorter decision-making process. In spite of all these advantages, there are challenges ahead of developing and using such systems including maintenance, required experts, inputting patients' data into the system, problems for knowledge acquisition, problems in modeling medical knowledge, evaluation and validation of system performance, wrong recommendations and responsibility, limited domains of such systems and necessity of integrating such systems into the routine work flows. We concluded that expert systems and neural networks can be successfully used in medicine; however, there are many concerns and questions to be answered through future studies and discussions.

  4. Health information systems: challenges for the 21st century.

    Science.gov (United States)

    Ball, M J; Lillis, J C

    2000-08-01

    No longer focused on mere automation of manual processes, healthcare technology is poised to transform practice. Healthcare information systems can extend and enhance the memory; streamline administrative processes; provide access to information where, when, and how it is needed; and manage the cost of care while protecting and improving clinical quality and customer satisfaction. To reap the benefits of information systems, healthcare professionals must take stock of the industry's current position on the road to transformation and determine how to manage the journey ahead. This article explores healthcare information technology trends, discusses emerging technologies such as the Internet and the computerized patient record, and offers future recommendations for achieving technology integration and acceptance. Key to this discussion is the belief that people-based skills such as cooperation, leadership, and creative thinking are just as important as--if not more important than--the actual technology.

  5. Water: Challenges at the Intersection of Human and Natural Systems

    Energy Technology Data Exchange (ETDEWEB)

    Futrell, J.H.; Gephart, R. E.; Kabat-Lensch, E.; McKnight, D. M.; Pyrtle, A.; Schimel, J. P.; Smyth, R. L.; Skole, D. L. Wilson, J. L.; Gephart, J. M.

    2005-09-01

    There is a growing recognition about the critical role water plays in sustaining people and society. This workshop established dialog between disciplinary scientists and program managers from diverse backgrounds in order to share perspectives and broaden community understanding of ongoing fundamental and applied research on water as a complex environmental problem. Three major scientific themes emerged: (1) coupling of cycles and process, with emphasis on the role of interfaces; (2) coupling of human and natural systems across spatial and temporal scales; and (3) prediction in the face of uncertainty. In addition, the need for observation systems, sensors, and infrastructure; and the need for data management and synthesis were addressed. Current barriers to progress were noted as educational and institutional barriers and the integration of science and policy.

  6. Challenge of Primary Voltage Control in Large Scale Wind Integrated Power System: A Danish Power System Case Study

    DEFF Research Database (Denmark)

    Rather, Zakir Hussain; Chen, Zhe; Thøgersen, Paul

    2013-01-01

    Grid integration of Renewable Energy (RE) at large scale poses vast majority of challenges to secure and stable operation of Power System. This paper presents the challenge of short circuit power and primary voltage control of wind integrated power system where majority of conventional generators...... of operational and future model of western Danish power system has been presented to support the effectiveness of demonstrated alternatives....... are replaced by wind generators. The impact of large scale wind integration on fast reactive power support is studied in this paper. Considering both technical and economic aspects, alternatives to address the challenge of dynamic voltage support have also been demonstrated in this paper. A case study...

  7. The Emergence of Enterprise Systems Management - A Challenge to the IS Curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    This paper proposes four cornerstones of a future Information Systems curriculum. It analyzes the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage resulting...... in the emergence of Enterprise Systems Management (ESM). Enterprise Systems Management calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways...

  8. The Emergence of Enterprise Systems Management - A Challenge to the IS Curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2005-01-01

    This paper proposes four cornerstones of a future Information Systems curriculum. It analyzes the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage resulting...... in the emergence of Enterprise Systems Management (ESM). Enterprise Systems Management calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways...

  9. Context-aware Recommender Systems for Learning: a Survey and Future Challenges

    NARCIS (Netherlands)

    Verbert, Katrien; Manouselis, Nikos; Xavier, Ochoa; Wolpers, Martin; Drachsler, Hendrik; Ivana, Bosnic; Erik, Duval

    2011-01-01

    Verbert, K., Manouselis, N., Xavier, O., Wolpers, M., Drachsler, H., Bosnic, I., & Duval, E. (accepted). Context-aware Recommender Systems for Learning: a Survey and Future Challenges. IEEE Transactions on Learning Technologies (TLT).

  10. Sustainable energy systems: Limitations and challenges based on exergy analysis

    OpenAIRE

    Woudstra, N.

    2012-01-01

    General There is a general understanding that the so-called “developed countries” have to change their way of life including their energy supply into a more sustainable way. But even in the case of unanimity with regard to the direction, there are still many opinions about the way to follow. This thesis discusses problems and possibilities of more sustainable energy systems first of all for the energy supply of the Netherlands. The “trias energetica” is used to distinguish the steps that have...

  11. Human capital flight challenges within an equitable health system.

    Science.gov (United States)

    Udonwa, N E

    2007-01-01

    The issue of human capital flight has been discussed at different forums with a consensus opinion that it has its merits and demerits to equitable health system. Most often one nation becomes a substantial net exporter of talent, leaving the provider nation at risk of depleting its natural supply of talent. This paper looks into the historical perspective of human capital flight or "brain drain", and its burden. It attempts to elucidate the various causes and suggested solutions. The paper's objective is to educate colleagues on the conceptual and contextual imperatives of the issue. Using a convenient sample of key informants who were medical colleagues in Nigeria relevant information was sourced from these colleagues, documents from the postgraduate medical college of Nigeria and the internet on maters relating to human capital flight and brain drain. Every year, thousands of qualified doctors, and other professionals leave Nigeria tempted by significantly higher wages, brighter prospects for employment and education, stability, food security. It appears that the potential exposure to different working conditions, resources and professional environments can be of advantage to the country, should Nigeria be able to recall these professionals. It also appears that necessary economic reforms that make staying at home rewarding, that is--good leadership, and policy planning that seriously looks into rural development, among other issues, are keys ingredients to reversing the trend in order to ensure a more equitable health system.

  12. Challenges in thermal and hydraulic analysis of ADS target systems

    International Nuclear Information System (INIS)

    Groetzbach, G.; Batta, A.; Lefhalm, C.-H.; Otic, I.

    2004-01-01

    The liquid metal cooled spallation targets of Accelerator Driven nuclear reactor Systems obey high thermal loads; in addition some flow and cooling conditions are of a prototypical character; in contrast the operating conditions for the engaged materials are narrow; thus, the target development requires a very careful analysis by experimental and numerical means. Especially the cooling of the steel window, which is heated by the proton beam, needs special care. Some of the main goals of the experimental and numerical analyses of the thermal dynamics of those systems are discusses. The prediction of locally detached flows and of flows with larger recirculation areas suffers from insufficient turbulence modeling; this has to be compensated by using prototypical model experiments, e.g. with water, to select the adequate models and numerical schemes. The well known problems with the Reynolds analogy in predicting the heat transfer in liquid metals requires always prototypic liquid metal experiments to select and adapt the turbulent heat flux models. The uncertainties in liquid metal experiments cannot be neglected; so it is necessary to perform CFD calculations and experiments always hand in hand and to develop improve turbulent heat flux models. One contribution to an improved 3 or 4-equation model is deduced from recent Direct Numerical Simulation (DNS) data. (author)

  13. Inclusive Education as Complex Process and Challenge for School System

    Directory of Open Access Journals (Sweden)

    Al-Khamisy Danuta

    2015-08-01

    Full Text Available Education may be considered as a number of processes, actions and effects affecting human being, as the state or level of the results of these processes or as the modification of the functions, institutions and social practices roles, which in the result of inclusion become new, integrated system. Thus this is very complex process. Nowadays the complexity appears to be one of very significant terms both in science and in philosophy. It appears that despite searching for simple rules, strategies, solutions everything is still more complex. The environment is complex, the organism living in it and exploring it, and just the exploration itself is a complex phenomenon, much more than this could initially seem to be.

  14. ETHICAL CHALLENGES OF THE E-LEARNING SYSTEM

    Directory of Open Access Journals (Sweden)

    MARIA CERNAT

    2013-05-01

    Full Text Available This article is the result of a four years teaching experience in one of the largest and controversial Romanian Universities using the E-learning system: Spiru Haret. It is a well-known fact that this was the first Romanian academic institution that used the E-learning techniques in wide and systematic way. Numerous articles appeared in the press in 2009 when the scandal of fake diplomas first started. This article is the perspective of an insider, that is, of someone who taught information and communication techniques in this institution for several years. I consider my experience and my findings to be balanced and objective and I also believe that we have to analyze things in a more profound and rational manner after the 2009 media storm ended. My article provides very useful information in this area since there are no academic articles on the way this Romanian academic institution (misunderstands the power of E-learning tools.

  15. Changing tax system challenges producers and refiners in Russia

    International Nuclear Information System (INIS)

    Khartukov, E.M.

    1996-01-01

    Over the past several years, economics of the Russian oil industry has undergone considerable change reflecting the radical transformation of the country's core industry from a wholly state-run and heftily subsidized distribution system toward a formally privatized, cash-strapped, and quasi-market entrepreneurship. All-out price liberalization, launched by the Russian government at the start of 1992, did not apply to the national oil industry. Domestic oil prices remained tangibly restrained until mid-1993 and were officially deregulated in March 1995. Consequently, rising costs diminished profit margins of Russian oil producers, whose operating costs were never as low as popularly believed. This paper reviews the tax structure of the Russian oil industry showing the effects on exports, gas prices at the pumps, and distribution prices

  16. The mental health system in Brazil: Policies and future challenges

    Directory of Open Access Journals (Sweden)

    Razzouk Denise

    2008-09-01

    Full Text Available Abstract Background The aim of this paper is to assess the mental health system in Brazil in relation to the human resources and the services available to the population. Methods The World Health Organization Assessment Instrument for Mental Health Systems (WHO AIMS was recently applied in Brazil. This paper will analyse data on the following sections of the WHO-AIMS: a mental health services; and b human resources. In addition, two more national datasets will be used to complete the information provided by the WHO questionnaire: a the Executive Bureau of the Department of Health (Datasus; and b the National Register of Health Institutions (CNS. Results There are 6003 psychiatrists, 18,763 psychologists, 1985 social workers, 3119 nurses and 3589 occupational therapists working for the Unified Health System (SUS. At primary care level, there are 104,789 doctors, 184, 437 nurses and nurse technicians and 210,887 health agents. The number of psychiatrists is roughly 5 per 100,000 inhabitants in the Southeast region, and the Northeast region has less than 1 psychiatrist per 100,000 inhabitants. The number of psychiatric nurses is insufficient in all geographical areas, and psychologists outnumber other mental health professionals in all regions of the country. The rate of beds in psychiatric hospitals in the country is 27.17 beds per 100,000 inhabitants. The rate of patients in psychiatric hospitals is 119 per 100,000 inhabitants. The average length of stay in mental hospitals is 65.29 days. In June 2006, there were 848 Community Psychosocial Centers (CAPS registered in Brazil, a ratio of 0.9 CAPS per 200,000 inhabitants, unequally distributed in the different geographical areas: the Northeast and the North regions having lower figures than the South and Southeast regions. Conclusion The country has opted for innovative services and programs, such as the expansion of Psychosocial Community Centers and the Return Home program to deinstitutionalize

  17. Computational brain models: Advances from system biology and future challenges

    Directory of Open Access Journals (Sweden)

    George E. Barreto

    2015-02-01

    Full Text Available Computational brain models focused on the interactions between neurons and astrocytes, modeled via metabolic reconstructions, are reviewed. The large source of experimental data provided by the -omics techniques and the advance/application of computational and data-management tools are being fundamental. For instance, in the understanding of the crosstalk between these cells, the key neuroprotective mechanisms mediated by astrocytes in specific metabolic scenarios (1 and the identification of biomarkers for neurodegenerative diseases (2,3. However, the modeling of these interactions demands a clear view of the metabolic and signaling pathways implicated, but most of them are controversial and are still under evaluation (4. Hence, to gain insight into the complexity of these interactions a current view of the main pathways implicated in the neuron-astrocyte communication processes have been made from recent experimental reports and reviews. Furthermore, target problems, limitations and main conclusions have been identified from metabolic models of the brain reported from 2010. Finally, key aspects to take into account into the development of a computational model of the brain and topics that could be approached from a systems biology perspective in future research are highlighted.

  18. The Geopolitics of Climate Change: Challenges to the International System

    International Nuclear Information System (INIS)

    Halden, Peter

    2007-12-01

    This report analyses the consequences of climate change and global warming for international politics in general and international security in particular. The report focuses on whether and in what way climate change may alter the conditions of international security. From this perspective, the initial effects of climate change will vary according to existing economic, political and social structures in different world regions. Organised violence is more likely in regions with weak states and conflictual inter-state dynamics than in those characterised by co-operative relations. In the short- to medium term, climate change is unlikely to alter the constitutive structures of international security. However, depending on the severity of climate change, these conditions may change over the long term. Such changes will probably depend on the secondary effects that change has on the world and regional economies. Climate change is unlikely to lead to an increase in conflicts in the short- to medium term, but a long-term development marked by unmitigated climate change could very well have serious consequences for international security. The report argues that, although necessary, mitigation and adaptation measures may have consequences for international politics. These are due to the changes in social and political systems that they entail

  19. The Geopolitics of Climate Change: Challenges to the International System

    Energy Technology Data Exchange (ETDEWEB)

    Halden, Peter

    2007-12-15

    This report analyses the consequences of climate change and global warming for international politics in general and international security in particular. The report focuses on whether and in what way climate change may alter the conditions of international security. From this perspective, the initial effects of climate change will vary according to existing economic, political and social structures in different world regions. Organised violence is more likely in regions with weak states and conflictual inter-state dynamics than in those characterised by co-operative relations. In the short- to medium term, climate change is unlikely to alter the constitutive structures of international security. However, depending on the severity of climate change, these conditions may change over the long term. Such changes will probably depend on the secondary effects that change has on the world and regional economies. Climate change is unlikely to lead to an increase in conflicts in the short- to medium term, but a long-term development marked by unmitigated climate change could very well have serious consequences for international security. The report argues that, although necessary, mitigation and adaptation measures may have consequences for international politics. These are due to the changes in social and political systems that they entail.

  20. The emergence of enterprise systems management: a challenge to the IS curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2006-01-01

    This paper proposes four cornerstones of a future Information Systems (IS) curriculum. It analyses the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage...... resulting in the emergence of Enterprise Systems Management (ESM). ESM calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways of approaching...

  1. The emergence of enterprise systems management: a challenge to the IS curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2006-01-01

    resulting in the emergence of Enterprise Systems Management (ESM). ESM calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways of approaching......This paper proposes four cornerstones of a future Information Systems (IS) curriculum. It analyses the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage...

  2. Some Challenges in the Design of Human-Automation Interaction for Safety-Critical Systems

    Science.gov (United States)

    Feary, Michael S.; Roth, Emilie

    2014-01-01

    Increasing amounts of automation are being introduced to safety-critical domains. While the introduction of automation has led to an overall increase in reliability and improved safety, it has also introduced a class of failure modes, and new challenges in risk assessment for the new systems, particularly in the assessment of rare events resulting from complex inter-related factors. Designing successful human-automation systems is challenging, and the challenges go beyond good interface development (e.g., Roth, Malin, & Schreckenghost 1997; Christoffersen & Woods, 2002). Human-automation design is particularly challenging when the underlying automation technology generates behavior that is difficult for the user to anticipate or understand. These challenges have been recognized in several safety-critical domains, and have resulted in increased efforts to develop training, procedures, regulations and guidance material (CAST, 2008, IAEA, 2001, FAA, 2013, ICAO, 2012). This paper points to the continuing need for new methods to describe and characterize the operational environment within which new automation concepts are being presented. We will describe challenges to the successful development and evaluation of human-automation systems in safety-critical domains, and describe some approaches that could be used to address these challenges. We will draw from experience with the aviation, spaceflight and nuclear power domains.

  3. Solar PV Project Financing: Regulatory and Legislative Challenges for Third-Party PPA System Owners

    Energy Technology Data Exchange (ETDEWEB)

    Kollins, K.; Speer, B.; Cory, K.

    2009-11-01

    Residential and commercial end users of electricity who want to generate electricity using on-site solar photovoltaic (PV) systems face challenging initial and O&M costs. The third-party ownership power purchase agreement (PPA) finance model addresses these and other challenges. It allows developers to build and own PV systems on customers? properties and sell power back to customers. However, third-party electricity sales commonly face five regulatory challenges. The first three challenges involve legislative or regulatory definitions of electric utilities, power generation equipment, and providers of electric services. These definitions may compel third-party owners of solar PV systems to comply with regulations that may be cost prohibitive. Third-party owners face an additional challenge if they may not net meter, a practice that provides significant financial incentive to owning solar PV systems. Finally, municipalities and cooperatives worry about the regulatory implications of allowing an entity to sell electricity within their service territories. This paper summarizes these challenges, when they occur, and how they have been addressed in five states. This paper also presents alternative to the third-party ownership PPA finance model, including solar leases, contractual intermediaries, standardized contract language, federal investment tax credits, clean renewable energy bonds, and waived monopoly powers.

  4. ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale

    DEFF Research Database (Denmark)

    Halling-Brown, M.; Pappalardo, F.; Rapin, Nicolas

    2010-01-01

    The ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model of the human immune system-that is, one that reflects both the diversity and the relative proportions of the molecules and cells that comprise it-together with the grid infrastructure necessary to apply...... this model to specific applications in the field of immunology. These objectives present the ImmunoGrid Consortium with formidable challenges in terms of complexity of the immune system, our partial understanding about how the immune system works, the lack of reliable data and the scale of computational...

  5. Challenge Study: A Project-Based Learning on a Wireless Communication System at Technical High School

    Science.gov (United States)

    Terasawa, Ikuo

    2016-01-01

    The challenge study is a project based learning curriculum at Technical High School aimed at the construction of a wireless communication system. The first period was engineering issues in the construction of an artificial satellite and the second period was a positional locating system based on the general purpose wire-less device--ZigBee device.…

  6. Challenge models to study the effect of immune system activation on amino acid metabolism in pigs

    NARCIS (Netherlands)

    Hoek, van de E.; Gerrits, W.J.J.; Borne, van den J.J.G.C.; Peet-Schwering, van der C.M.C.; Beers, van H.; Jansman, A.J.M.

    2013-01-01

    In response to (non-)pathogenic challenges, the immune system of pigs can be activated. During immune system activation, there is a competition for amino acids (AA) between body protein deposition (growth) and immune function (Sandberg et al., 2007). As a consequence, feed intake and growth are

  7. Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions

    NARCIS (Netherlands)

    Sandy, Heleau; Drachsler, Hendrik; Gillet, Dennis

    2009-01-01

    Heleou, S., Drachsler, H., & Gillet, D. (2009). Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions. 1st workshop on Context-aware Recommender Systems for Learning at the Alpine Rendez-Vous. November, 30-December, 3, 2009, Garmisch-Patenkirchen,

  8. Why we need resilience thinking to meet societal challenges in bio-based production systems

    NARCIS (Netherlands)

    Ge, L.; Anten, N.P.R.; Dixhoorn, van I.D.E.; Feindt, P.H.; Kramer, K.; Leemans, H.B.J.; Gielen-Meuwissen, M.P.M.; Spoolder, H.A.M.; Sukkel, W.

    2016-01-01

    The need to feed an increasing world population and to
    respond to the effects of climate change creates
    unprecedented challenges for bio-based production systems.
    Many of these systems have been designed to maximize
    productivity and efficiency under standard

  9. Use of Point-of-Service Systems in School Nutrition Programs: Types, Challenges, and Employee Training

    Science.gov (United States)

    Lee, Yee Ming; Kwon, Junehee; Park, Eunhye; Wang, Yujia; Rushing, Keith

    2017-01-01

    Purpose/Objectives: This study investigated the use of electronic and paper-based point-of-service (POS) systems in school nutrition programs (SNPs), including associated challenges and the desired skills and existing training practices for personnel handling such systems. Methods: A questionnaire was developed based on interviews with 25 SNP…

  10. Challenges in the Development of Environmental Management Systems on the Modern University Campus

    Science.gov (United States)

    Bero, Bridget N.; Doerry, Eckehard; Middleton, Ryan; Meinhardt, Christian

    2012-01-01

    Purpose: The purpose of this paper is to describe challenges and lessons learned in the design and development of a comprehensive, flexible environmental management system (EMS) in a real university setting; also to inform development of similar systems elsewhere and provide a modular, extensible software architecture for such efforts.…

  11. Challenges and Benefits of Standardising Early Warning Systems: A Case Study of New Zealand’s Volcanic Alert Level System

    OpenAIRE

    Fearnley, C. J.; Potter, S. H.; Scott, B. J.; Leonard, G. S.; Gregg, C. E.

    2017-01-01

    Volcano early warning systems are used globally to communicate volcano-related information to diverse stakeholders ranging from specific user groups to the general public, or both. Within the framework of a volcano early warning system, Volcano Alert Level (VAL) systems are commonly used as a simple communication tool to inform society about the status of activity at a specific volcano. Establishing a VAL system that is effective for multiple volcanoes can be challenging, given that each volc...

  12. Health systems research in fragile and conflict affected states: a qualitative study of associated challenges.

    Science.gov (United States)

    Woodward, Aniek; Sheahan, Kate; Martineau, Tim; Sondorp, Egbert

    2017-06-07

    High quality health systems research (HSR) in fragile and conflict-affected states (FCAS) is essential to guiding the policies and programmes that will improve access to health services and, ultimately, health outcomes. Yet, conducting HSR in FCAS is challenging. An understanding of these challenges is essential to tackling them and to supporting research conducted in these complex environments. Led by the Thematic Working Group on Health Systems in FCAS, the primary aim of this study was to develop a research agenda on HSR in FCAS. The secondary aim was to identify the challenges associated with conducting HSR in these contexts. This paper presents these challenges. Guided by a purposely-selected steering group, this qualitative study collected respondents' perspectives through an online survey (n = 61) and a group discussion at the Third Global Symposium on HSR in September 2014 (n = 11). Respondents with knowledge and/or experience of HSR in FCAS were intentionally recruited. Of those ever involved in HSR in FCAS (45/61, 75%), almost all (98%) experienced challenges in conducting their research. Challenges fall under three broad thematic areas: (1) lack of appropriate support; (2) complex local research environment, including access constraints, weak local research capacity, collaboration challenges and lack of trust in the research process; and (3) limited research application, including rapidly outdated findings and lack of engagement with the research process and results. This study shows that those familiar with HSR in FCAS face many challenges in gaining support for and in conducting and applying high-quality research. There is a need for more sustainable support, including commitment to and long-term funding of HSR in FCAS; investment in capacity building within FCAS to meet the challenges related to implementation of research in these complex environments; relationship and trust building among stakeholders involved in HSR, particularly between local and

  13. Reverse engineering biomolecular systems using −omic data: challenges, progress and opportunities

    Science.gov (United States)

    Quo, Chang F.; Kaddi, Chanchala; Phan, John H.; Zollanvari, Amin; Xu, Mingqing

    2012-01-01

    Recent advances in high-throughput biotechnologies have led to the rapid growing research interest in reverse engineering of biomolecular systems (REBMS). ‘Data-driven’ approaches, i.e. data mining, can be used to extract patterns from large volumes of biochemical data at molecular-level resolution while ‘design-driven’ approaches, i.e. systems modeling, can be used to simulate emergent system properties. Consequently, both data- and design-driven approaches applied to –omic data may lead to novel insights in reverse engineering biological systems that could not be expected before using low-throughput platforms. However, there exist several challenges in this fast growing field of reverse engineering biomolecular systems: (i) to integrate heterogeneous biochemical data for data mining, (ii) to combine top–down and bottom–up approaches for systems modeling and (iii) to validate system models experimentally. In addition to reviewing progress made by the community and opportunities encountered in addressing these challenges, we explore the emerging field of synthetic biology, which is an exciting approach to validate and analyze theoretical system models directly through experimental synthesis, i.e. analysis-by-synthesis. The ultimate goal is to address the present and future challenges in reverse engineering biomolecular systems (REBMS) using integrated workflow of data mining, systems modeling and synthetic biology. PMID:22833495

  14. Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities.

    Science.gov (United States)

    Quo, Chang F; Kaddi, Chanchala; Phan, John H; Zollanvari, Amin; Xu, Mingqing; Wang, May D; Alterovitz, Gil

    2012-07-01

    Recent advances in high-throughput biotechnologies have led to the rapid growing research interest in reverse engineering of biomolecular systems (REBMS). 'Data-driven' approaches, i.e. data mining, can be used to extract patterns from large volumes of biochemical data at molecular-level resolution while 'design-driven' approaches, i.e. systems modeling, can be used to simulate emergent system properties. Consequently, both data- and design-driven approaches applied to -omic data may lead to novel insights in reverse engineering biological systems that could not be expected before using low-throughput platforms. However, there exist several challenges in this fast growing field of reverse engineering biomolecular systems: (i) to integrate heterogeneous biochemical data for data mining, (ii) to combine top-down and bottom-up approaches for systems modeling and (iii) to validate system models experimentally. In addition to reviewing progress made by the community and opportunities encountered in addressing these challenges, we explore the emerging field of synthetic biology, which is an exciting approach to validate and analyze theoretical system models directly through experimental synthesis, i.e. analysis-by-synthesis. The ultimate goal is to address the present and future challenges in reverse engineering biomolecular systems (REBMS) using integrated workflow of data mining, systems modeling and synthetic biology.

  15. Addressing Energy System Modelling Challenges: The Contribution of the Open Energy Modelling Framework (oemof)

    DEFF Research Database (Denmark)

    Hilpert, Simon; Günther, Stephan; Kaldemeyer, Cord

    2017-01-01

    complexity of energy systems and high uncertainties on different levels. In addition, interdisciplinary modelling is necessary for getting insight in mechanisms of an integrated world. At the same time models need to meet scientific standards as public acceptance becomes increasingly important......The process of modelling energy systems is accompanied by challenges inherently connected with mathematical modelling. However, due to modern realities in the 21st century, existing challenges are gaining in magnitude and are supplemented with new ones. Modellers are confronted with a rising....... In this intricate environment model application as well as result communication and interpretation is also getting more difficult. In this paper we present the open energy modelling framework (oemof) as a novel approach for energy system modelling and derive its contribution to existing challenges. Therefore, based...

  16. Pre-Ebola virus disease laboratory system and related challenges in Liberia

    Directory of Open Access Journals (Sweden)

    Stephen B. Kennedy

    2016-10-01

    Full Text Available Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of effective and sustainablelaboratory services in Liberia. However, in a resource-limited environment such as Liberiaprogress regarding the rebuilding of the health system can be relatively slow, while efforts tosustain the transient gains remain a key challenge for the Ministry of Health. In this paper, wedescribe the pre-Ebola virus disease laboratory system in Liberia and its prevailing efforts toaddress future emerging infectious diseases, as well as current Infectious diseases, all of whichare exacerbated by poverty. We conclude that laboratory and diagnostic services in Liberiahave encountered numerous challenges regarding its efforts to strengthen the healthcaredelivery system. These challenges include limited trained human resource capacity, inadequateinfrastructure, and a lack of coordination. As with most countries in sub-Saharan Africa, whencomparing urban and rural settings, diagnostic and clinical services are generally skewedtoward urban health facilities and private, faith-based health facilities. We recommend thatstructured policy be directed at these challenges for national institutions to develop guidelinesto improve, strengthen and sustain diagnostic and curative laboratory services to effectivelyaddress current infectious diseases and prepare for future emerging and re-emerging infectiousdiseases.

  17. JACoW Challenges of the ALICE Detector Control System for the LHC RUN3

    CERN Document Server

    Chochula, Peter; Bond, Peter; Kurepin, Alexander; Lechman, Mateusz; Lang, John; Pinazza, Ombretta

    2018-01-01

    The ALICE Detector Control System (DCS) has provided its services to the experiment since 10 years. During this period it ensured uninterrupted operation of the experiment and guaranteed stable conditions for the data taking. The DCS has been designed to cope with the detector requirements compatible with the LHC operation during its RUN1 and RUN2 phases. The decision to extend the lifetime of the experiment beyond this horizon requires the redesign of the DCS data flow and represents a major challenge. The major challenges of the system upgrade are presented in this paper.

  18. BIG DATA-Related Challenges and Opportunities in Earth System Modeling

    Science.gov (United States)

    Bamzai, A. S.

    2012-12-01

    Knowledge of the Earth's climate has increased immensely in recent decades, both through observational analysis and modeling. BIG DATA-related challenges emerge in our quest for understanding the variability and predictability of the climate and earth system on a range of time scales, as well as in our endeavor to improve predictive capability using state-of-the-science models. To enable further scientific discovery, bottlenecks in current paradigms need to be addressed. An overview of current NSF activities in Earth System Modeling with a focus on associated data-related challenges and opportunities, will be presented.

  19. Rectifier Design Challenges for RF Wireless Power Transfer and Energy Harvesting Systems

    Directory of Open Access Journals (Sweden)

    A. Collado

    2017-06-01

    Full Text Available The design of wireless power transfer (WPT and energy harvesting (EH solutions poses different challenges towards achieving maximum RF-DC conversion efficiency in these systems. This paper covers several selected challenges when developing WPT and electromagnetic EH solutions, such as the design of multiband and broadband rectifiers, the minimization of the effect that load and input power variations may have on the system performance and finally the most optimum power combining mechanisms that can be used when dealing with multi-element rectifiers.

  20. INTEGRATION CHALLENGES OF UNIVERSITY AND INFORMATION MANAGEMENT SYSTEM (UIMS TO MOODLE

    Directory of Open Access Journals (Sweden)

    Jyldyzbek J. Jakshylykov

    2016-06-01

    Full Text Available Introduction: in 2006 an International Ataturk Ala-Too University (IAAU began to adopt internationally recognised Bologna system, which was initiated by the Ministry of Science and Education of Kyrgyz Republic because of problems of managerial and educational problems at universities in Kyrgyzstan. Consequently, IAAU had to improve its information and grading system and created University Information and Manage¬ment System (UIMS, which was developed by the university professional team including the author. At the same time, the university began to apply a Moodle software, which delivers open source management system programs, in order to appropriately manage teaching proc esses and manage courses online. Materials and Methods: the methodological basis of the research are descriptive method, analysis, and comparison. Results: however, the IAAU faced some challenged issues in the application of the two innovation, which was the integration challenges of those Moodle and UIMS. Hence, the main purpose of this study is to demonstrate benefits of Moodle and UIMS linking challenges. at first, this paper informs Moodle functions, features, advantages and disadvantages in a shortly manner and UIMS management features and primary functions, which included six fundamentally crucial processes with some graphical representations. In addition, the analysis and methodologies of two systems through identifying advantages and disadvantages for the possible integ ration. Discussion and Conclusions: at the end, some challenged issues were identified from analysis results, also Moodle and UIMS benefits were demonstrated in the International Ataturk Ala-Too University.

  1. Hybrid Societies: Challenges and Perspectives in the Design of Collective Behavior in Self-organizing Systems

    Directory of Open Access Journals (Sweden)

    Heiko eHamann

    2016-04-01

    Full Text Available Hybrid societies are self-organizing, collective systems composed of different components, for example, natural and artificial parts (bio-hybrid or human beings interacting with and through technical systems (socio-technical. Many different disciplines investigate methods and systems closely related to the design of hybrid societies. A~stronger collaboration between these disciplines could allow for re-use of methods and create significant synergies. We identify three main areas of challenges in the design of self-organizing hybrid societies. First, we identify the formalization challenge. There is an urgent need for a generic model that allows a description and comparison of collective hybrid societies. Second, we identify the system design challenge. Starting from the formal specification of the system, we need to develop an integrated design process. Third, we identify the challenge of interdisciplinarity. Current research on self-organizing hybrid societies stretches over many different fields and hence requires the re-use and synthesis of methods at intersections between disciplines. We then conclude by presenting our perspective for future approaches with high potential in this area.

  2. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry.

    Science.gov (United States)

    Iannaccone, Mario; D'Ascenzo, Fabrizio; Frangieh, Antonio H; Niccoli, Giampaolo; Ugo, Fabrizio; Boccuzzi, Giacomo; Bertaina, Maurizio; Mancone, Massimo; Montefusco, Antonio; Amabile, Nicolas; Sardella, Gennaro; Motreff, Pascal; Toutouzas, Konstantinos; Colombo, Francesco; Garbo, Roberto; Biondi-Zoccai, Giuseppe; Tamburino, Corrado; Omedè, Pierluigi; Moretti, Claudio; D'amico, Maurizio; Souteyrand, Geraud; Meieir, Pascal; Lüscher, Thomas F; Gaita, Fiorenzo; Templin, Christian

    2017-08-01

    To determine the potential clinical impact of OCT (Optical Coherence Tomography) during primary percutaneous coronary intervention in patients presenting with ACS (Acute Coronary Syndrome). FORMIDABLE is a multicentre retrospective registry enrolling all patients presenting with ACS and treated with an OCT-guided approach, while the USZ registry enrolled patients treated with a standard angiography guided approach. Multivariate adjustment was performed via a propensity score matching. The number stents useds was the primary outcome, while the incidence of MACE (a composite of death, myocardial infarction, target vessel revascularization, and stent thrombosis) was the secondary endpoint. A total of 285 patients OCT-guided and 1,547 angiography guided patients were enrolled, resulting in 270 for each cohort after propensity score with matching. Two stents were used in 12% versus 34%; 3 stents in 8% versus 38% of the patients (P < 0.001). After a follow up of 700 days (450-890), there was no difference in myocardial infarction (6% vs. 6%, P = 0.86), while MACE (11% vs. 16%, P = 0.06), target vessel revascularization (2% vs. 4%, P = 0.15) and stent thrombosis rates (0% vs. 2.7%, P = 0.26) were numerically lower for the OCT-guided cohort but none of these endpoints did reach statistical significance. An OCT-guided approach reduced the number of stents used, number of patients treated with more than one stent, while there was no statistically significant difference in clinical endpoints while most of them were numerically lower, including stent thrombosis rates. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry.

    Science.gov (United States)

    Barbero, Umberto; Scacciatella, Paolo; Iannaccone, Mario; D'Ascenzo, Fabrizio; Niccoli, Giampaolo; Colombo, Francesco; Ugo, Fabrizio; Colangelo, Salvatore; Mancone, Massimo; Calcagno, Simone; Sardella, Gennaro; Amabile, Nicolas; Motreff, Pascal; Toutouzas, Konstantinos; Garbo, Roberto; Tamburino, Corrado; Montefusco, Antonio; Omedè, Pierluigi; Moretti, Claudio; D'amico, Maurizio; Souteyrand, Geraud; Gaita, Fiorenzo; Templin, Christian

    2017-07-12

    Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years). Primary end-point was the prevalence of plaque rupture (PR). Secondary end point was the prevalence of thin cap fibro atheroma (TCFA), fibrocalcific and fibrotic plaque. 285 patients were included, 71 (24.9%) in juvenile-ACS group and 215 (75.1%) in not juvenile-ACS group. Younger patients showed a trend for a higher prevalence of TCFA (70 vs. 58%, P = 0.06) and thrombus presence (62 vs. 51%, P = 0.1), while no statistical difference concerning PR (70 vs. 64%, P = 0.29). Of interest patients younger that 35 years showed a higher prevalence of PR compared to patients aged between 35 and 45 or 45 and 50 years (100 vs. 72 vs. 55%, P = 0.03). Culprit plaque in juvenile-ACS group showed more frequently a reduced mean cap thickness (119 ± 66 vs. 155 ± 95 nm, P = 0.05) and less frequently fibrotic (32 vs. 57%, P < 0.001) or fibrocalcific (17 vs. 36%, P = 0.003) characteristics. young patients with ACS show a trend for a higher prevalence of culprit PR, a thinner cap and less fibrotic or fibrocalcific components. © 2017 Wiley Periodicals, Inc.

  4. Challenges when evaluating Product/Service-Systems through Life Cycle Assessment

    DEFF Research Database (Denmark)

    Kjær, Louise Laumann; Pagoropoulos, Aris; Schmidt, Jannick H.

    2016-01-01

    the environmental performance of PSS. We identify a set of PSS characteristics that can challenge an LCA study. Three relevant scopes are distinguished, where LCA may be applied: (1) evaluating options within the PSS itself; (2) comparing a PSS with an alternative; and (3) modelling the actual contextual changes...... caused by the PSS. We derive three pronounced challenges when conducting LCA within the three scopes: (i) identifying and defining the reference system; (ii) defining the functional unit; and (iii) setting system boundaries. We elaborate on how these challenges are discussed in current literature....... Recommended future work includes developing adapted guidelines and further empirical case studies that quantify the environmental changes and impacts caused by introducing PSS....

  5. Challenges of using Hospital Information Systems by nurses: comparing academic and non-academic hospitals.

    Science.gov (United States)

    Ahmadian, Leila; Dorosti, Nafise; Khajouei, Reza; Gohari, Sadrieh Hajesmaeel

    2017-06-01

    Hospital Information Systems (HIS) are used for easy access to information, improvement of documentation and reducing errors. Nonetheless, using these systems is faced with some barriers and obstacles. This study identifies the challenges and the obstacles of using these systems in the academic and non-academic hospitals in Kerman. This is a cross-sectional study which was carried out in 2015. The statistical population in this study consisted of the nurses who had been working in the academic and non-academic hospitals in Kerman. A questionnaire consisting of two sections was used. The first section consisted of the demographic information of the participants and the second section comprised 34 questions about the challenges of HIS use. Data were analyzed by the descriptive and statistical analysis (t-test, and ANOVA) using SPSS 19 software. The most common and important challenges in the academic hospitals were about human environment factors, particularly "negative attitude of society toward using HIS". In the non-academic hospitals, the most common and important challenges were related to human factors, and among them, "no incentive to use system" was the main factor. The results of the t-test method revealed that there was a significant relationship between gender and the mean score of challenges related to the organizational environment category in the academic hospitals and between familiarity with HIS and mean score of human environment factors (pinformation systems are the factors related to the human environment and the human factors. The results of this study can bring a good perspective to the policy makers and the managers regarding obstacles of using HISs from the nurses' perspective, so that they can solve their problems and can successfully implement these systems.

  6. Measurement of cold challenge responses in primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis.

    Science.gov (United States)

    O'Reilly, D; Taylor, L; el-Hadidy, K; Jayson, M I

    1992-01-01

    Using computed thermography continuous temperature recordings were made before and after cold challenge of the fingers of control subjects and patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis. Basal skin temperature measurements (Tpre) were significantly lower in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis than in the controls. Temperatures immediately after cold challenge (T0) were significantly lower in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis than in controls. The lag phase before the start of temperature recovery (Tlag) was significantly greater in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis than in control subjects. The maximum recovery index (R%) was significantly less in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis than in controls. The maximum rate of change of temperature during the rapid phase of rewarming (Gmax) was significantly greater in controls than in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis. Discriminant analysis showed that the dynamic parameters of rewarming (Tlag, Gmax, and R%) showed greater variation between the patients with primary Raynaud's phenomenon and those with Raynaud's phenomenon associated with systemic sclerosis than did Tpre or T0. This method of analysis of cold challenge will be used in studies of the effects of treatment of Raynaud's phenomenon. PMID:1466594

  7. Toward an Integrated Competence-based System Supporting Lifelong Learning and Employability: Concepts, Model, and Challenges

    NARCIS (Netherlands)

    Miao, Yongwu; Van der Klink, Marcel; Boon, Jo; Sloep, Peter; Koper, Rob

    2009-01-01

    Miao, Y., Van der Klink, M., Boon, J., Sloep, P. B., & Koper, R. (2009). Toward an Integrated Competence-based System Supporting Lifelong Learning and Employability: Concepts, Model, and Challenges. In M. Spaniol, Q. Li, R. Klamma & R. W. H. Lau (Eds.), Proceedings of the 8th International

  8. Preparing Information Systems (IS) Graduates to Meet the Challenges of Global IT Security: Some Suggestions

    Science.gov (United States)

    Sauls, Jeff; Gudigantala, Naveen

    2013-01-01

    Managing IT security and assurance is a top priority for organizations. Aware of the costs associated with a security or privacy breach, organizations are constantly vigilant about protecting their data and IT systems. In addition, organizations are investing heavily in IT resources to keep up with the challenges of managing their IT security and…

  9. Towards a Standardized e-Assessment System: Motivations, Challenges and First Findings

    Directory of Open Access Journals (Sweden)

    Denis Helic

    2009-10-01

    Full Text Available “Global Learning” with shared learning contents, resources, activities and goals is one of the contributions of Globalization. With the capability to use new Information and Communication Technologies (ICT it is a bit easier to have a technology based learning systems that enable learners to share the learning resources and possibilities. As a result many Learning Management Systems (LMS were developed with divers of platforms and approaches. Consequently, sharing learning resources and components has become a major challenge. E-assessment as a primary activity of any LMS is facing the same challenges and problems. In order to stand on this challenge people in the field of technology enhanced learning have recommended that LMS should conform to specific standards. This paper discuses this challenge, the consequences and limitations of standards in the modern learning settings. Moreover, it shows a service oriented framework for assessment which aims to make the e-assessment systems flexible and also to initiate the term of “Global Learning Assessment” with the possibility of sharing the e-assessment system components.

  10. Facing the challenges of distribution systems operation with high wind power penetration

    DEFF Research Database (Denmark)

    Das, Kaushik; Altin, Müfit; Hansen, Anca Daniela

    This paper addresses the challenges associated with the operation of a distribution system with high penetration of wind power. The paper presents some preliminary investigations of an ongoing Danish research work, which has as main objective to reduce the network losses by optimizing the reactive...

  11. Legitimacy challenges of intermediary gatekeeping in the Chinese internet regulatory system

    NARCIS (Netherlands)

    Wei, Lulu

    2018-01-01

    Legitimacy Challenges of Intermediary Gatekeeping in the Chinese Internet Regulatory System In the Chinese legal and political framework, in order for the government to maintain control over information posted on social media platforms, commercial internet intermediaries are assigned the role of

  12. Building an Agricultural Extension Services System Supported by ICTs in Tanzania: Progress Made, Challenges Remain

    Science.gov (United States)

    Sanga, C.; Kalungwizi, V. J.; Msuya, C. P.

    2013-01-01

    The conventional agricultural extension service in Tanzania is mainly provided by extension officers visiting farmers to provide agricultural advisory service. This system of extension service provision faces a number of challenges including the few number of extension officers and limited resources. This article assesses the effectiveness of an…

  13. Toward an Integrated Competence-based System Supporting Lifelong Learning and Employability: Concepts, Model, and Challenges

    NARCIS (Netherlands)

    Miao, Yongwu; Van der Klink, Marcel; Boon, Jo; Sloep, Peter; Koper, Rob

    2009-01-01

    Miao, Y., Van der Klink, M., Boon, J., Sloep, P. B., & Koper, R. (2009). Toward an Integrated Competence-based System Supporting Lifelong Learning and Employability: Concepts, Model, and Challenges. Presentation at the 8th International Conference Advances in Web Based Learning - ICWL 2009. August,

  14. Information and Communications Technology (ICT) in Nigeria Educational Assessment System--Emerging Challenges

    Science.gov (United States)

    Aworanti, Olatunde Awotokun

    2016-01-01

    This paper examines Information and Communications Technology (ICT) in Nigeria educational assessment system with its emerging challenges. This is inevitable following the globalisation trend which has brought drastic changes in the world of technology. The essence of the paper is to describe the present status of ICT in the Nigeria educational…

  15. Understanding Challenges in the Front Lines of Home Health Care: A Human-Systems Approach

    Science.gov (United States)

    Beer, Jenay M.; McBride, Sara E.; Mitzner, Tracy L.; Rogers, Wendy A.

    2014-01-01

    A human-systems perspective is a fruitful approach to understanding home health care because it emphasizes major individual components of the system – persons, equipment/technology, tasks, and environments –as well as the interaction between these components. The goal of this research was to apply a human-system perspective to consider the capabilities and limitations of the persons, in relation to the demands of the tasks and equipment/technology in home health care. Identification of challenges and mismatches between the person(s) capabilities and the demands of providing care provide guidance for human factors interventions. A qualitative study was conducted with 8 home health Certified Nursing Assistants and 8 home health Registered Nurses interviewed about challenges they encounter in their jobs. A systematic categorization of the challenges the care providers reported was conducted and human factors recommendations were proposed in response, to improve home health. The challenges inform a human-systems model of home health care. PMID:24958610

  16. Organic Coasts? Regulatory Challenges of Certifying Integrated Shrimp-Mangrove Production Systems in Vietnam

    Science.gov (United States)

    Ha, Tran Thi Thu; Bush, Simon R.; Mol, Arthur P. J.; van Dijk, Han

    2012-01-01

    The Vietnamese government aims to expand the scale of Naturland certified organic production in integrated shrimp-mangrove farming systems across the coast of Ca Mau province by 2015. In doing so the division between public and private regulation has become blurred. We analyze the government's goal by examining the regulatory challenges of using…

  17. Verification and Validation Challenges for Adaptive Flight Control of Complex Autonomous Systems

    Science.gov (United States)

    Nguyen, Nhan T.

    2018-01-01

    Autonomy of aerospace systems requires the ability for flight control systems to be able to adapt to complex uncertain dynamic environment. In spite of the five decades of research in adaptive control, the fact still remains that currently no adaptive control system has ever been deployed on any safety-critical or human-rated production systems such as passenger transport aircraft. The problem lies in the difficulty with the certification of adaptive control systems since existing certification methods cannot readily be used for nonlinear adaptive control systems. Research to address the notion of metrics for adaptive control began to appear in the recent years. These metrics, if accepted, could pave a path towards certification that would potentially lead to the adoption of adaptive control as a future control technology for safety-critical and human-rated production systems. Development of certifiable adaptive control systems represents a major challenge to overcome. Adaptive control systems with learning algorithms will never become part of the future unless it can be proven that they are highly safe and reliable. Rigorous methods for adaptive control software verification and validation must therefore be developed to ensure that adaptive control system software failures will not occur, to verify that the adaptive control system functions as required, to eliminate unintended functionality, and to demonstrate that certification requirements imposed by regulatory bodies such as the Federal Aviation Administration (FAA) can be satisfied. This presentation will discuss some of the technical issues with adaptive flight control and related V&V challenges.

  18. Challenges in developing a comprehensive, automated and flexible oil accounting system

    Energy Technology Data Exchange (ETDEWEB)

    Nordell, L.F.; Ruda, H. [Enbridge Pipelines Inc., Edmonton, AB (Canada)

    2004-07-01

    Enbridge Pipelines Inc. operates a long and complex system of pipelines which transport hydrocarbon liquid commodities, including crude oils, refined products and natural gas liquids across provincial and national boundaries. Due to growing internal demands for the addition of pipelines, the company developed a comprehensive oil accounting (OA) system in 1998. The OA accommodated changing business requirements by incorporating more complex tariff agreements and the demand for customized system reporting for customers. The new OA was also compatible with the company's technology direction, which focused on aligning information technology (IT) with business drivers and upgrading the flexibility of the entire OA system. This paper summarized the business improvement and redevelopment study; the OA system redevelopment project; challenges of integrating new system components with the legacy system during system development; specific process improvement results that were targeted and achieved by the new system development team; and, the project development challenges. The project team adopted a software development approach that was responsive to changes in the requirements and in the project direction introduced by key stakeholders during the life of the project. The project management approaches and logic of the SCRUM and extreme programming (XP) methods were combined to incorporate the principles of agile development to ensure a quality product. The result was an automated crude oil balancing and revenue accounting system that interfaced with other pipeline management software systems. 6 refs., 5 figs.

  19. The Grand Challenges of WCRP and the Climate Observing System of the Future

    Science.gov (United States)

    Brasseur, G. P.

    2017-12-01

    The successful implementation the Paris agreement on climate change (COP21) calls for a well-designed global monitoring system of essential climate variables, climate processes and Earth system budgets. The Grand Challenges implemented by the World Climate Research Programme (WCRP) provide an opportunity to investigate issues of high societal relevance, directly related to sea level rise, droughts, floods, extreme heat events, food security, and fresh water availability. These challenges would directly benefit from a well-designed suite of systematic climate observations. Quantification of the evolution of the global energy, water and carbon budgets as well as the development and the production of near-term and regional climate predictions require that a comprehensive, focused, multi-platform observing system (satellites, ground-based and in situ observations) be established in an international context. This system must be accompanied by the development of climate services that should translate and disseminate scientific outcomes as actionable information for users and stakeholders.

  20. Benefits and challenges of cloud ERP systems – A systematic literature review

    Directory of Open Access Journals (Sweden)

    Mohamed A. Abd Elmonem

    2016-12-01

    Full Text Available Enterprise Resource Planning (ERP systems provide extensive benefits and facilities to the whole enterprise. ERP systems help the enterprise to share and transfer data and information across all functions units inside and outside the enterprise. Sharing data and information between enterprise departments helps in many aspects and aims to achieve different objectives. Cloud computing is a computing model which takes place over the internet and provides scalability, reliability, availability and low cost of computer reassures. Implementing and running ERP systems over the cloud offers great advantages and benefits, in spite of its many difficulties and challenges. In this paper, we follow the Systematic Literature Review (SLR research method to explore the benefits and challenges of implementing ERP systems over a cloud environment.

  1. Trust Evaluation for Embedded Systems Security research challenges identified from an incident network scenario

    OpenAIRE

    Gehrmann, Christian; Löfvenberg , Jacob

    2011-01-01

    This paper is about trust establishment and trust evaluations techniques. A short background about trust, trusted computing and security in embedded systems is given. An analysis has been done of an incident network scenario with roaming users and a set of basic security needs has been identified. These needs have been used to derive security requirements for devices and systems, supporting the considered scenario. Using the requirements, a list of major security challenges for...

  2. Cervical cancer data and data systems in limited-resource settings: Challenges and opportunities.

    Science.gov (United States)

    Drummond, Jennifer L; Were, Martin C; Arrossi, Silvina; Wools-Kaloustian, Kara

    2017-07-01

    Appropriate collection and use of health information is critical to the planning, scaling up, and improvement of cervical cancer programs. The health information systems implementation landscape is unique to each country; however, systems serving cervical cancer programs in low-resource settings share characteristics that present common challenges. In response, many programs have taken innovative approaches to generating the quality information needed for decision making. Recent advances in health information technology also provide feasible solutions to challenges. This article draws from the experiences of the authors and from current literature to describe outstanding challenges and promising practices in the implementation of cervical cancer data systems, and to make recommendations for next steps. Recommendations include engaging all stakeholders-including providers, program managers, implementing partners, and donors-in promoting national, district, and community information systems; building on existing systems and processes, as well as introducing new technologies; and evolving data collection and data systems as programs advance. © 2017 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.

  3. Social work in the Veterans Health Administration (VA) System: rewards, challenges, roles and interventions.

    Science.gov (United States)

    Beder, Joan; Postiglione, Paul

    2013-01-01

    For the social worker in the Veterans Health Administration (VA) System, numerous challenges are faced and met while serving the nation's Veterans. As part of the multidisciplinary team, social workers perform a variety of tasks and function in diverse roles. The qualitative survey research reported in this article sought to detail what social workers identified about the impact and rewards of their work and what they saw as the challenges and frustrations. In addition the social workers were asked to clarify their role with the patient and the family. Intervention strategies used in the course of the social workers interaction with the Veterans was also ascertained.

  4. MIT-QCRI Arabic Dialect Identification System for the 2017 Multi-Genre Broadcast Challenge

    OpenAIRE

    Shon, Suwon; Ali, Ahmed; Glass, James

    2017-01-01

    In order to successfully annotate the Arabic speech con- tent found in open-domain media broadcasts, it is essential to be able to process a diverse set of Arabic dialects. For the 2017 Multi-Genre Broadcast challenge (MGB-3) there were two possible tasks: Arabic speech recognition, and Arabic Dialect Identification (ADI). In this paper, we describe our efforts to create an ADI system for the MGB-3 challenge, with the goal of distinguishing amongst four major Arabic dialects, as well as Moder...

  5. Reinforced Ultra-Tightly Coupled GPS/INS System for Challenging Environment

    Directory of Open Access Journals (Sweden)

    Xueyun Wang

    2014-01-01

    Full Text Available Among all integration levels currently available for Global Positioning System (GPS and Inertial Navigation System (INS Integrated System, ultra-tightly coupled (UTC GPS/INS system is the best choice for accurate and reliable navigation. Nevertheless the performance of UTC GPS/INS system degrades in challenging environments, such as jamming, changing noise of GPS signals, and high dynamic maneuvers. When low-end Inertial Measurement Units (IMUs based on MEMS sensors are employed, the performance degradation will be more severe. To solve this problem, a reinforced UTC GPS/INS system is proposed. Two techniques are adopted to deal with jamming and high dynamics. Firstly, adaptive integration Kalman filter (IKF based on fuzzy logics is developed to reinforce the antijamming ability. The parameters of membership functions (MFs are adjusted and optimized through self-developed neutral network. Secondly, a Doppler frequency error estimator based on Kalman filter is designed to improve the navigation performance under high dynamics. A complete simulation platform is established to evaluate the reinforced system. Results demonstrate that the proposed system architecture significantly improves navigation performance in challenging environments and it is a more advanced solution to accurate and reliable navigation than traditional UTC GPS/INS system.

  6. Industrial Adoption of Model-Based Systems Engineering: Challenges and Strategies

    Science.gov (United States)

    Maheshwari, Apoorv

    As design teams are becoming more globally integrated, one of the biggest challenges is to efficiently communicate across the team. The increasing complexity and multi-disciplinary nature of the products are also making it difficult to keep track of all the information generated during the design process by these global team members. System engineers have identified Model-based Systems Engineering (MBSE) as a possible solution where the emphasis is placed on the application of visual modeling methods and best practices to systems engineering (SE) activities right from the beginning of the conceptual design phases through to the end of the product lifecycle. Despite several advantages, there are multiple challenges restricting the adoption of MBSE by industry. We mainly consider the following two challenges: a) Industry perceives MBSE just as a diagramming tool and does not see too much value in MBSE; b) Industrial adopters are skeptical if the products developed using MBSE approach will be accepted by the regulatory bodies. To provide counter evidence to the former challenge, we developed a generic framework for translation from an MBSE tool (Systems Modeling Language, SysML) to an analysis tool (Agent-Based Modeling, ABM). The translation is demonstrated using a simplified air traffic management problem and provides an example of a potential quite significant value: the ability to use MBSE representations directly in an analysis setting. For the latter challenge, we are developing a reference model that uses SysML to represent a generic infusion pump and SE process for planning, developing, and obtaining regulatory approval of a medical device. This reference model demonstrates how regulatory requirements can be captured effectively through model-based representations. We will present another case study at the end where we will apply the knowledge gained from both case studies to a UAV design problem.

  7. Model-based nonlinear control of hydraulic servo systems: Challenges, developments and perspectives

    Science.gov (United States)

    Yao, Jianyong

    2017-11-01

    Hydraulic servo system plays a significant role in industries, and usually acts as a core point in control and power transmission. Although linear theory-based control methods have been well established, advanced controller design methods for hydraulic servo system to achieve high performance is still an unending pursuit along with the development of modern industry. Essential nonlinearity is a unique feature and makes model-based nonlinear control more attractive, due to benefit from prior knowledge of the servo valve controlled hydraulic system. In this paper, a discussion for challenges in model-based nonlinear control, latest developments and brief perspectives of hydraulic servo systems are presented: Modelling uncertainty in hydraulic system is a major challenge, which includes parametric uncertainty and time-varying disturbance; some specific requirements also arise ad hoc difficulties such as nonlinear friction during low velocity tracking, severe disturbance, periodic disturbance, etc.; to handle various challenges, nonlinear solutions including parameter adaptation, nonlinear robust control, state and disturbance observation, backstepping design and so on, are proposed and integrated, theoretical analysis and lots of applications reveal their powerful capability to solve pertinent problems; and at the end, some perspectives and associated research topics (measurement noise, constraints, inner valve dynamics, input nonlinearity, etc.) in nonlinear hydraulic servo control are briefly explored and discussed.

  8. HIV Infection among People Who Inject Drugs: The Challenge of Racial/Ethnic Disparities

    Science.gov (United States)

    Des Jarlais, Don C.; McCarty, Dennis; Vega, William A.; Bramson, Heidi

    2013-01-01

    Racial/ethnic disparities in HIV infection, with minority groups typically having higher rates of infection, are a formidable public health challenge. In the United States, among both men and women who inject drugs, HIV infection rates are elevated among Hispanics and non-Hispanic Blacks. A meta-analysis of international research concluded that…

  9. The main technological R and D challenges for future nuclear systems

    International Nuclear Information System (INIS)

    Billot, Ph.; Carre, F.

    2006-01-01

    The search for natural resources saving, for a minimum production of radioactive wastes and for the direct use of high temperature heat in industrial applications, are the main context elements that influence today the development of future nuclear systems. The priority has been given to fast neutron systems with closed fuel cycle, while the second goal requires a very high temperature system. The common technological challenges of the very-high temperature gas-cooled thermal neutron system (VHTR) and of the gas-cooled fast neutron system (GFR) are the high temperature resistant materials, the helium generic technology, and the gas turbine technology of the power generation system. The specific problems raised by both systems concern the fuel and the management of accidental situations. (J.S.)

  10. Large system change challenges: addressing complex critical issues in linked physical and social domains

    Science.gov (United States)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

    2015-04-01

    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  11. Technology Challenges and Opportunities for Very Large In-Space Structural Systems

    Science.gov (United States)

    Belvin, W. Keith; Dorsey, John T.; Watson, Judith J.

    2009-01-01

    Space solar power satellites and other large space systems will require creative and innovative concepts in order to achieve economically viable designs. The mass and volume constraints of current and planned launch vehicles necessitate highly efficient structural systems be developed. In addition, modularity and in-space deployment/construction will be enabling design attributes. While current space systems allocate nearly 20 percent of the mass to the primary structure, the very large space systems of the future must overcome subsystem mass allocations by achieving a level of functional integration not yet realized. A proposed building block approach with two phases is presented to achieve near-term solar power satellite risk reduction with accompanying long-term technology advances. This paper reviews the current challenges of launching and building very large space systems from a structures and materials perspective utilizing recent experience. Promising technology advances anticipated in the coming decades in modularity, material systems, structural concepts, and in-space operations are presented. It is shown that, together, the current challenges and future advances in very large in-space structural systems may provide the technology pull/push necessary to make solar power satellite systems more technically and economically feasible.

  12. Challenges of Utilizing E-Learning Systems in Public Universities in Jordan

    Directory of Open Access Journals (Sweden)

    Muhannad Anwar Al-Shboul

    2010-06-01

    Full Text Available This research paper lists and discusses major challenges and barriers that may face faculty members at the public universities in Jordan in employing e-Learning systems authoring tools in their instructions. It also proposes several suggestions for the administrators in public universities in Jordan for what they could do to improve the utilization of e-Learning authoring tools at their campuses. E-Learning systems authoring tools allow instructors to easily create and deliver their e-contents and e-lectures. Furthermore, online course materials which uploaded by using such authoring tools could be viewed by any popular web browser system.

  13. A Systematic Review of Wearable Patient Monitoring Systems - Current Challenges and Opportunities for Clinical Adoption.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Moqeem, Aasia A; Mirza, Farhaan; Lindén, Maria

    2017-07-01

    The aim of this review is to investigate barriers and challenges of wearable patient monitoring (WPM) solutions adopted by clinicians in acute, as well as in community, care settings. Currently, healthcare providers are coping with ever-growing healthcare challenges including an ageing population, chronic diseases, the cost of hospitalization, and the risk of medical errors. WPM systems are a potential solution for addressing some of these challenges by enabling advanced sensors, wearable technology, and secure and effective communication platforms between the clinicians and patients. A total of 791 articles were screened and 20 were selected for this review. The most common publication venue was conference proceedings (13, 54%). This review only considered recent studies published between 2015 and 2017. The identified studies involved chronic conditions (6, 30%), rehabilitation (7, 35%), cardiovascular diseases (4, 20%), falls (2, 10%) and mental health (1, 5%). Most studies focussed on the system aspects of WPM solutions including advanced sensors, wireless data collection, communication platform and clinical usability based on a specific area or disease. The current studies are progressing with localized sensor-software integration to solve a specific use-case/health area using non-scalable and 'silo' solutions. There is further work required regarding interoperability and clinical acceptance challenges. The advancement of wearable technology and possibilities of using machine learning and artificial intelligence in healthcare is a concept that has been investigated by many studies. We believe future patient monitoring and medical treatments will build upon efficient and affordable solutions of wearable technology.

  14. A Perspective on Smart Process Manufacturing Research Challenges for Process Systems Engineers

    Directory of Open Access Journals (Sweden)

    Ian David Lockhart Bogle

    2017-04-01

    Full Text Available The challenges posed by smart manufacturing for the process industries and for process systems engineering (PSE researchers are discussed in this article. Much progress has been made in achieving plant- and site-wide optimization, but benchmarking would give greater confidence. Technical challenges confronting process systems engineers in developing enabling tools and techniques are discussed regarding flexibility and uncertainty, responsiveness and agility, robustness and security, the prediction of mixture properties and function, and new modeling and mathematics paradigms. Exploiting intelligence from big data to drive agility will require tackling new challenges, such as how to ensure the consistency and confidentiality of data through long and complex supply chains. Modeling challenges also exist, and involve ensuring that all key aspects are properly modeled, particularly where health, safety, and environmental concerns require accurate predictions of small but critical amounts at specific locations. Environmental concerns will require us to keep a closer track on all molecular species so that they are optimally used to create sustainable solutions. Disruptive business models may result, particularly from new personalized products, but that is difficult to predict.

  15. Assessing Vulnerability to Climate Change in Dryland Livelihood Systems: Conceptual Challenges and Interdisciplinary Solutions

    Directory of Open Access Journals (Sweden)

    Evan D. G. Fraser

    2011-09-01

    Full Text Available Over 40% of the earth's land surface are drylands that are home to approximately 2.5 billion people. Livelihood sustainability in drylands is threatened by a complex and interrelated range of social, economic, political, and environmental changes that present significant challenges to researchers, policy makers, and, above all, rural land users. Dynamic ecological and environmental change models suggest that climate change induced drought events may push dryland systems to cross biophysical thresholds, causing a long-term drop in agricultural productivity. Therefore, research is needed to explore how development strategies and other socioeconomic changes help livelihoods become more resilient and robust at a time of growing climatic risk and uncertainty. As a result, the overarching goal of this special feature is to conduct a structured comparison of how livelihood systems in different dryland regions are affected by drought, thereby making methodological, empirical, and theoretical contributions to our understanding of how these types of social-ecological systems may be vulnerable to climate change. In introducing these issues, the purpose of this editorial is to provide an overview of the two main intellectual challenges of this work, namely: (1 how to conceptualize vulnerability to climate change in coupled social-ecological systems; and (2 the methodological challenges of anticipating trends in vulnerability in dynamic environments.

  16. Managing the Interoperability and Privacy of e-Health Systems as an Interdisciplinary Challenge

    Directory of Open Access Journals (Sweden)

    Alexandru Soceanu

    2016-10-01

    Full Text Available The growing number of patients with chronic diseases, the ageing population worldwide, the rapid increase in hospital costs and in the cost of care personnel as well as the achieving medical objectives "increase the patient quality of life and survival" face Europe with a huge challenge. One of the solutions for reaching these challenges in the future is the deployment of complex eHealth systems in support of all the healthcare aspects on the way between patient home and healthcare provider. In the last decade the European Commission (EC in cooperation with healthcare associations and standardization institutes announced large frameworks for supporting research and development of various components of the future eHealth systems. This may be considered as an immediate interdisciplinary opportunity for European researchers and developers to create jointly the spine of future healthcare systems. After a short introduction to eHealth architecture, interoperability, security and privacy the talk refers to the interdisciplinary solutions which approach these healthcare huge overall challenge. Two case studies will be addressed: a interdisciplinary partnership for conducting jointly European research concerning remote control and management of future wearable dialysis devices, and b ERASMUS supported international education programs for creating future interdisciplinary expert networks working on developing and implementing a better healthcare system.

  17. [Challenges to Latin-American health systems: what can be learned from the European experience?].

    Science.gov (United States)

    Figueras, J; Musgrove, P; Carrin, G; Durán, A

    2002-01-01

    This article compares the challenges of health systems in Latin America and the experience in Europe. The framework is the analysis of four functions: a) to generate resources; b) to produce activities; c) to finance, and d) to exercise stewardship. It is at this level where actors can influence health system responsiveness. Five challenges are identified in Latin America: a) to extend (prepayment and solidarity) financial protection; b) to stabilise that protection for crisis times; c) to equilibrate resources in accordance to capacity for financing services; d) to increase efficiency (technical and of placement) to produce services, and e) to improve the stewardship function in public and private sectors (the most important and difficult challenge Latin-American systems have nowadays). The experience of reform in Europe is analysed, showing: a) experiences about financial protection in Beveridge and Bismarck systems; b) stability in crisis times, recently confirm (West) and with important obstacles (East); c) efforts to equilibrate hospital beds and health care professionals, combining regulation and incentives; d) increase of efficiency in services production, with more express prioritisation, empowering patients, decentralising management and with market incentives, and e) improvement of stewardship with better (not less, sometimes even more) regulation. Three areas of European experience stand out: a) to combine solidarity with financial sustainability; b) to introduce market incentives in a measured way, but maintaining a clear stewardship role for the state, and c) to adopt innovations in organising and producing services. In spite of methodological difficulties, convergence of challenges and adopted solutions justify this analysis, but learning must be seen in each national context. A future article will analyse lessons offered by reform in Latin-American systems for European reforms.

  18. Security challenges in designing I and C systems for nuclear power plant

    International Nuclear Information System (INIS)

    Behera, Rajendra Prasad; Jayanthi, T.; Madhusoodanan, K.; Satya Murty, S.A.V.

    2016-01-01

    Geographically distributed instrumentation and control (I and C) systems in any nuclear power plant (NPP) facilitate the operator with remote access to real-time data and issue supervisory command to remote control devices deployed in the field. The increased connectivity to plant communication network has exposed I and C systems to security vulnerabilities both in terms of physical and logical access. For example, denial-of service and fault induction attack can disrupt the operation of I and C systems by delaying or blocking the flow of data through plant communication network. The design process of I and C system is quite challenging since an engineer has to consider both safety and security features implemented in hardware and software components of the system. This paper analyzes attack taxonomy based on available data and presents Security Tree Analysis (STA) technique towards building safe and secures I and C systems for Nuclear Power Plant. (author)

  19. Incorporating Systems Science Principles into the Development of Obesity Prevention Interventions: Principles, Benefits, and Challenges.

    Science.gov (United States)

    Gittelsohn, Joel; Mui, Yeeli; Adam, Atif; Lin, Sen; Kharmats, Anna; Igusa, Takeru; Lee, Bruce Y

    2015-06-01

    Systems modeling represents an innovative approach for addressing the obesity epidemic at the community level. We developed an agent-based model of the Baltimore City food environment that permits us to assess the relative impact of different programs and policies, alone and in combination, and potential unexpected consequences. Based on this experience, and a review of literature, we have identified a set of principles, potential benefits, and challenges. Some of the key principles include the importance of early and multilevel engagement with the community prior to initiating model development and continued engagement and testing with community stakeholders. Important benefits include improving community stakeholder understanding of the system, testing of interventions before implementation, and identification of unexpected consequences. Challenges in these models include deciding on the most important, yet parsimonious factors to consider, how to model food source and food selection behavior in a realistic yet transferable manner, and identifying the appropriate outcomes and limitations of the model.

  20. Gay, lesbian, and bisexual foster parents: strengths and challenges for the child welfare system.

    Science.gov (United States)

    Downs, A Chris; James, Steven E

    2006-01-01

    Historically, a shortage of skilled and dedicated foster parents has existed in America. Lesbian, gay, or bisexual (LBG) foster parents have received little attention in the published literature. This article documents the challenges and successes of a group of 60 LGB foster parents. All participants provided foster parenting for public (state or county) agencies. The primary successes of this group included meaningful and gratifying parenting and successful testing of whether adoption might be a natural next step after foster parenting. The primary challenges included insensitive, inappropriate, and difficult social workers; state or local laws that worked against successful foster parenting by LGB adults; failure to recognize parents' partners; and lack of support by the system to acknowledge the important role of LGB parents. Numerous recommendations are identified for improving how LGB foster parents are supported within child welfare systems including foster parent and social worker training in LGB issues.

  1. Analysis of Aviation Safety Reporting System Incident Data Associated With the Technical Challenges of the Vehicle Systems Safety Technology Project

    Science.gov (United States)

    Withrow, Colleen A.; Reveley, Mary S.

    2014-01-01

    This analysis was conducted to support the Vehicle Systems Safety Technology (VSST) Project of the Aviation Safety Program (AVsP) milestone VSST4.2.1.01, "Identification of VSST-Related Trends." In particular, this is a review of incident data from the NASA Aviation Safety Reporting System (ASRS). The following three VSST-related technical challenges (TCs) were the focus of the incidents searched in the ASRS database: (1) Vechicle health assurance, (2) Effective crew-system interactions and decisions in all conditions; and (3) Aircraft loss of control prevention, mitigation, and recovery.

  2. IT-security challenges in IoT environments and autonomous systems

    Science.gov (United States)

    Heun, Ulrich

    2017-05-01

    Internet of Things will open the digital world for future services working across company borders. Together with autonomous systems intelligent things will communicate and work together without direct influence of human technicians or service managers. IT-security will become one of the most important challenges to ensure a stable service performance and to provide a trustful environment to let people use such service without any concerns regarding data privacy and eligibility of the outcomes.

  3. Challenges facing the distribution of an artificial-intelligence-based system for nursing.

    Science.gov (United States)

    Evans, S

    1985-04-01

    The marketing and successful distribution of artificial-intelligence-based decision-support systems for nursing face special barriers and challenges. Issues that must be confronted arise particularly from the present culture of the nursing profession as well as the typical organizational structures in which nurses predominantly work. Generalizations in the literature based on the limited experience of physician-oriented artificial intelligence applications (predominantly in diagnosis and pharmacologic treatment) must be modified for applicability to other health professions.

  4. Challenges to strengthening agricultural innovation systems: where do we go from here?

    OpenAIRE

    Hall, A.

    2007-01-01

    This paper was prepared to present at the Farmer First Revisited: 20 Years On conference at IDS, University of Sussex, UK, December 2007. Its focus is the challenge of strengthening agricultural innovation systems. The paper prefaces this discussion by reflecting on an apparent paradox. While agricultural innovation has never been better studied and understood, many of our ideas about innovation have failed to fundamentally change the institutional and policy setting of public and private inv...

  5. Challenges to deployment of twenty-first century nuclear reactor systems

    Science.gov (United States)

    Ion, Sue

    2017-02-01

    The science and engineering of materials have always been fundamental to the success of nuclear power to date. They are also the key to the successful deployment and operation of a new generation of nuclear reactor systems and their associated fuel cycles. This article reflects on some of the historical issues, the challenges still prevalent today and the requirement for significant ongoing materials R&D and discusses the potential role of small modular reactors.

  6. Challenges to deployment of twenty-first century nuclear reactor systems

    OpenAIRE

    Ion, Sue

    2017-01-01

    The science and engineering of materials have always been fundamental to the success of nuclear power to date. They are also the key to the successful deployment and operation of a new generation of nuclear reactor systems and their associated fuel cycles. This article reflects on some of the historical issues, the challenges still prevalent today and the requirement for significant ongoing materials R&D and discusses the potential role of small modular reactors.

  7. A suite of benchmark and challenge problems for enhanced geothermal systems

    Energy Technology Data Exchange (ETDEWEB)

    White, Mark; Fu, Pengcheng; McClure, Mark; Danko, George; Elsworth, Derek; Sonnenthal, Eric; Kelkar, Sharad; Podgorney, Robert

    2017-11-06

    A diverse suite of numerical simulators is currently being applied to predict or understand the performance of enhanced geothermal systems (EGS). To build confidence and identify critical development needs for these analytical tools, the United States Department of Energy, Geothermal Technologies Office sponsored a Code Comparison Study (GTO-CCS), with participants from universities, industry, and national laboratories. A principal objective for the study was to create a community forum for improvement and verification of numerical simulators for EGS modeling. Teams participating in the study were those representing U.S. national laboratories, universities, and industries, and each team brought unique numerical simulation capabilities to bear on the problems. Two classes of problems were developed during the study, benchmark problems and challenge problems. The benchmark problems were structured to test the ability of the collection of numerical simulators to solve various combinations of coupled thermal, hydrologic, geomechanical, and geochemical processes. This class of problems was strictly defined in terms of properties, driving forces, initial conditions, and boundary conditions. The challenge problems were based on the enhanced geothermal systems research conducted at Fenton Hill, near Los Alamos, New Mexico, between 1974 and 1995. The problems involved two phases of research, stimulation, development, and circulation in two separate reservoirs. The challenge problems had specific questions to be answered via numerical simulation in three topical areas: 1) reservoir creation/stimulation, 2) reactive and passive transport, and 3) thermal recovery. Whereas the benchmark class of problems were designed to test capabilities for modeling coupled processes under strictly specified conditions, the stated objective for the challenge class of problems was to demonstrate what new understanding of the Fenton Hill experiments could be realized via the application of

  8. [Challenges of an integrative and personalised health care for health economics and the insurance system].

    Science.gov (United States)

    Schoch, Goentje-Gesine; Würdemann, E

    2014-11-01

    "Stratifying medicine" is a topic of increasing importance in the public health system. There are several questions related to "stratifying medicine". This paper reconsiders definitions, opportunities and risks related to "stratifying medicine" as well as the main challenges of "stratifying medicine" from the perspective of a public health insurance. The application of the term and the definition are important points to discuss. Terms such as "stratified medicine", "personalised medicine" or "individualised medicine" are used. The Techniker Krankenkasse prefers "stratifying medicine", because it usually means a medicine that tailors therapy to specific groups of patients by biomarkers. OPPORTUNITIES AND RISKS: "Stratifying medicine" is associated with various hopes, e. g., the avoidance of ineffective therapies and early detection of diseases. But "stratifying medicine" also carries risks, such as an increase in the number of cases by treatment of disease risks, a duty for health and the weakening of the criteria of evidence-based medicine. The complexity of "stratifying medicine" is a big challenge for all involved parties in the health system. A lot of interrelations are still not completely understood. So the statutory health insurance faces the challenge of making innovative therapy concepts accessible in a timely manner to all insured on the one hand but on the other hand also to protect the community from harmful therapies. Information and advice to patients related to "stratifying medicine" is of particular importance. The equitable distribution of fees for diagnosis and counselling presents a particular challenge. The solidarity principle of public health insurance may be challenged by social and ethical issues of "stratifying medicine". "Stratifying medicine" offers great potential to improve medical care. However, false hopes must be avoided. Providers and payers should measure chances and risks of "stratifying medicine" together for the welfare of the

  9. Cloud service performance evaluation: status, challenges, and opportunities – a survey from the system modeling perspective

    Directory of Open Access Journals (Sweden)

    Qiang Duan

    2017-05-01

    Full Text Available With rapid advancement of Cloud computing and networking technologies, a wide spectrum of Cloud services have been developed by various providers and utilized by numerous organizations as indispensable ingredients of their information systems. Cloud service performance has a significant impact on performance of the future information infrastructure. Thorough evaluation on Cloud service performance is crucial and beneficial to both service providers and consumers; thus forming an active research area. Some key technologies for Cloud computing, such as virtualization and the Service-Oriented Architecture (SOA, bring in special challenges to service performance evaluation. A tremendous amount of effort has been put by the research community to address these challenges and exciting progress has been made. Among the work on Cloud performance analysis, evaluation approaches developed with a system modeling perspective play an important role. However, related works have been reported in different sections of the literature; thus lacking a big picture that shows the latest status of this area. The objectives of this article is to present a survey that reflects the state of the art of Cloud service performance evaluation from the system modeling perspective. This articles also examines open issues and challenges to the surveyed evaluation approaches and identifies possible opportunities for future research in this important field.

  10. Changing societies and four tasks of schooling: Challenges for strongly differentiated educational systems

    Science.gov (United States)

    van de Werfhorst, Herman G.

    2014-05-01

    Changing labour markets, increased calls for selection and excellence, and increased diversity and individualisation have repercussions on how educational systems can prepare youth for work, optimise knowledge production, achieve equality of opportunity, and socialise students into active civic engagement. This paper discusses four central tasks of schooling and examines to what extent societal developments challenge education policy to deliver on the tasks at hand. Particular attention is given to the challenges Europe's strongly diversified educational systems are currently facing. Both the Netherlands and Germany, for example, have been offering vocationally-oriented pathways alongside traditional academic higher education for some time. But today's ongoing changes in job descriptions, mainly due to ever-accelerating technological developments, are causing a risk of skills obsolescence which can only be avoided by continuous upskilling and/or reskilling of a sufficiently flexible workforce. Overcoming differences of intelligence as well as differences of diverse socioeconomic, ethnic and linguistic backgrounds by way of education is another challenge, as is fostering "soft" skills and political awareness. This paper investigates the effectiveness of current education systems in preparing citizens for a functioning modern society.

  11. Overcoming Health System Challenges for Women and Children Living With HIV Through the Global Plan

    Science.gov (United States)

    Modi, Surbhi; Callahan, Tegan; Rodrigues, Jessica; Kajoka, Mwikemo D.; Dale, Helen M.; Langa, Judite O.; Urso, Marilena; Nchephe, Matsepeli I.; Bongdene, Helene; Romano, Sostena; Broyles, Laura N.

    2017-01-01

    To meet the ambitious targets set by the Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), the initial 22 priority countries quickly developed innovative approaches for overcoming long-standing health systems challenges and providing HIV testing and treatment to pregnant and breastfeeding women and their infants. The Global Plan spurred programs for prevention of mother-to-child HIV transmission to integrate HIV-related care and treatment into broader maternal, newborn, and child health services; expand the effectiveness of the health workforce through task sharing; extend health services into communities; strengthen supply chain and commodity management systems; reduce diagnostic and laboratory hurdles; and strengthen strategic supervision and mentorship. The article reviews the ongoing challenges for prevention of mother-to-child HIV transmission programs as they continue to strive for elimination of vertical transmission of HIV infection in the post-Global Plan era. Although progress has been rapid, health systems still face important challenges, particularly follow-up and diagnosis of HIV-exposed infants, continuity of care, and the promotion of services that are respectful and client centered. PMID:28399000

  12. Future evolution of distributed systems for smart grid - The challenges and opportunities to using decentralized energy system

    Science.gov (United States)

    Konopko, Joanna

    2015-12-01

    A decentralized energy system is a relatively new approach in the power industry. Decentralized energy systems provide promising opportunities for deploying renewable energy sources locally available as well as for expanding access to clean energy services to remote communities. The electricity system of the future must produce and distribute electricity that is reliable and affordable. To accomplish these goals, both the electricity grid and the existing regulatory system must be smarter. In this paper, the major issues and challenges in distributed systems for smart grid are discussed and future trends are presented. The smart grid technologies and distributed generation systems are explored. A general overview of the comparison of the traditional grid and smart grid is also included.

  13. Greenlandic water and sanitation-a context oriented analysis of system challenges towards local sustainable development.

    Science.gov (United States)

    Hendriksen, Kåre; Hoffmann, Birgitte

    2017-08-28

    Today, as Greenland focuses on more economic and cultural autonomy, the continued development of societal infrastructure systems is vital. At the same time, pressure is put on the systems by a lack of financial resources and locally based professional competences as well as new market-based forms of organization. Against this background, the article discusses the challenges facing Greenland's self-rule in relation to further develop the existing water and wastewater systems so that they can contribute to the sustainable development of Greenland. The article reviews the historical development of the water supply and wastewater system. This leads to an analysis of the sectorisation, which in recent decades has reorganized the Greenlandic infrastructures, and of how this process is influencing local sustainable development. The article discusses the socio-economic and human impacts and points to the need for developing the water and sanitation system to support not only hygiene and health, but also local sustainable development.

  14. Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

    Science.gov (United States)

    Singh, Mrityunjay

    2010-01-01

    Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

  15. The Diagnostic Challenge Competition: Probabilistic Techniques for Fault Diagnosis in Electrical Power Systems

    Science.gov (United States)

    Ricks, Brian W.; Mengshoel, Ole J.

    2009-01-01

    Reliable systems health management is an important research area of NASA. A health management system that can accurately and quickly diagnose faults in various on-board systems of a vehicle will play a key role in the success of current and future NASA missions. We introduce in this paper the ProDiagnose algorithm, a diagnostic algorithm that uses a probabilistic approach, accomplished with Bayesian Network models compiled to Arithmetic Circuits, to diagnose these systems. We describe the ProDiagnose algorithm, how it works, and the probabilistic models involved. We show by experimentation on two Electrical Power Systems based on the ADAPT testbed, used in the Diagnostic Challenge Competition (DX 09), that ProDiagnose can produce results with over 96% accuracy and less than 1 second mean diagnostic time.

  16. Challenges and opportunities of using recommender systems for personalized health education.

    Science.gov (United States)

    Fernandez-Luque, Luis; Karlsen, Randi; Vognild, Lars K

    2009-01-01

    The use of computers in health education started more than a decade ago, mainly for tailoring health educational resources. Nowadays, many of the computer-tailoring health education systems are using the Internet for delivering different types of health education. Traditionally, these systems are designed for a specific health problem, with a predefined library of educational resources. These systems do not take advantage of the increasing amount of educational resources available on the Internet. One of the reasons is that the high availability of content is making it more difficult to find the relevant one. The problem of information overload has been addressed for many years in the field of recommender systems. This paper is focused on the challenges and opportunities of merging recommender systems with personalized health education. It also discusses the usage of social networks and semantic technologies within this approach.

  17. Public Health System in Brazil nowadays: challenges for its operation and funding

    Directory of Open Access Journals (Sweden)

    Alethele de Oliveira Santos

    2016-09-01

    Full Text Available This paper has the aim to revisit the theme of the brazilian public health system from the perspective of its operation and funding of its actions and services, analyzing some of the main obstacles to its effectiveness. Endowed with its own logic of organization, planning and funding of its actions and services, the Brazilian Unified Health System (SUS finds barriers to its sustainability when it comes to funding and the judicialization of health. Historical under-funding worsened by the economic and political crisis the country currently faces plus the increase in casuistic judicial decisions that prioritize the individual logic over the collective right have produced serious shocks in the system. These are just some of the challenges to an effective public health system. This is why the work of public bodies must be responsible and always take into consideration the collective dimension of the right to health under penalty of causing the collapse of the public health system altogether.

  18. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2015-10-01

    Full Text Available Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX, are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

  19. A Systematic Review of Wearable Systems for Cancer Detection: Current State and Challenges.

    Science.gov (United States)

    Ray, Partha Pratim; Dash, Dinesh; De, Debashis

    2017-10-02

    Rapid growth of sensor and computing platforms have introduced the wearable systems. In recent years, wearable systems have led to new applications across all medical fields. The aim of this review is to present current state-of-the-art approach in the field of wearable system based cancer detection and identify key challenges that resist it from clinical adoption. A total of 472 records were screened and 11 were finally included in this study. Two types of records were studied in this context that includes 45% research articles and 55% manufactured products. The review was performed per PRISMA guidelines where considerations was given to records that were published or reported between 2009 and 2017. The identified records included 4 cancer detecting wearable systems such as breast cancer (36.3%), skin cancer (36.3%), prostate cancer (18.1%), and multi-type cancer (9%). Most works involved sensor based smart systems comprising of microcontroller, Bluetooth module, and smart phone. Few demonstrated Ultra-Wide Band (i.e. UWB) antenna based wearable systems. Skin cancer detecting wearable systems were most comprehensible ones. The current works are gradually progressing with seamless integration of sensory units along with smart networking. However, they lack in cloud computing and long-range communication paradigms. Artificial intelligence and machine learning are key ports that need to be attached with current wearable systems. Further, clinical inertia, lack of awareness, and high cost are altogether pulling back the actual growth of such system. It is well comprehended that upon sincere orientation of all identified challenges, wearable systems would emerge as vital alternative to futuristic cancer detection.

  20. Drivers and challenges for implementing ISO 14001 environmental management systems in an emerging Gulf Arab country.

    Science.gov (United States)

    Waxin, Marie-France; Knuteson, Sandra L; Bartholomew, Aaron

    2017-11-13

    Worldwide, ISO 14001 certification for organizations has become the norm, but the Arab world accounts for an insignificant portion of all the certified organizations. There is a dearth of research on environmental management systems (EMS) in Arab and emerging countries and in public organizations. The objectives of this research are to: (1) examine the key drivers and challenges related to implementation of ISO 14001 certified EMS in the United Arab Emirates, an emerging Arab country and (2) compare and contrast these drivers and challenges between private and public organizations. We adopt an explorative, qualitative methodology, using semi-structured interviews with environmental managers in 11 organizations (6 private and 5 public) from different industrial sectors. Drivers of EMS certification were mostly similar between private and public organizations, with some differences. Compliance with regulations and standards, and increasing environmental performance were the main drivers for ISO 14001 certification in both private and public organizations. Commitment to sustainability was more important for public organizations. Cost reduction, competitors, leadership commitment and customers' demands were shared drivers, but more stressed by private organizations. Local community and employees' pressures were reported by private organizations only. The challenges to ISO 14001 implementation were similar for private and public organizations. They were: a lack of qualified human resources, practical challenges associated with implementation, a lack of regulations, a lack of support from management, and high costs. Our findings have implications for managers, academics, consultants, and policy makers in the UAE and other emerging markets.

  1. PRODUCT INFORMATION MANAGEMENT IN E‐COMMERCE SYSTEMS : CHALLENGES AND BEST PRACTICES

    OpenAIRE

    Kubisztal, Justyna

    2013-01-01

    E­‐commerce became a widely spread platform used both by enterprises as well as private customers. Since product information became more and more complex, new tools were needed and systems such as Products Information Management were created. Despite the fact that PIM system solves several common problems with data for e-­commerce, it still has its own challenges.This study shows examples of different solutions for same kind of products and common problems with its attributes that are c...

  2. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

    Directory of Open Access Journals (Sweden)

    Krstic Dimitrije

    2012-07-01

    Full Text Available Abstract Background Alzheimer’s disease (AD is the most prevalent form of age-related dementia, and its effect on society increases exponentially as the population ages. Accumulating evidence suggests that neuroinflammation, mediated by the brain’s innate immune system, contributes to AD neuropathology and exacerbates the course of the disease. However, there is no experimental evidence for a causal link between systemic inflammation or neuroinflammation and the onset of the disease. Methods The viral mimic, polyriboinosinic-polyribocytidilic acid (PolyI:C was used to stimulate the immune system of experimental animals. Wild-type (WT and transgenic mice were exposed to this cytokine inducer prenatally (gestation day (GD17 and/or in adulthood. Behavioral, immunological, immunohistochemical, and biochemical analyses of AD-associated neuropathologic changes were performed during aging. Results We found that a systemic immune challenge during late gestation predisposes WT mice to develop AD-like neuropathology during the course of aging. They display chronic elevation of inflammatory cytokines, an increase in the levels of hippocampal amyloid precursor protein (APP and its proteolytic fragments, altered Tau phosphorylation, and mis-sorting to somatodendritic compartments, and significant impairments in working memory in old age. If this prenatal infection is followed by a second immune challenge in adulthood, the phenotype is strongly exacerbated, and mimics AD-like neuropathologic changes. These include deposition of APP and its proteolytic fragments, along with Tau aggregation, microglia activation and reactive gliosis. Whereas Aβ peptides were not significantly enriched in extracellular deposits of double immune-challenged WT mice at 15 months, they dramatically increased in age-matched immune-challenged transgenic AD mice, precisely around the inflammation-induced accumulations of APP and its proteolytic fragments, in striking similarity to

  3. Crohn's disease presenting as gastric outlet obstruction: a therapeutic challenge?

    Science.gov (United States)

    Inayat, Faisal; Ullah, Waqas; Hussain, Qulsoom; Shafique, Khurram

    2017-04-28

    Isolated gastric Crohn's disease with initial presentation related to gastric outlet obstruction is an unusual clinicopathological entity. We undertake here a literature review of this rare initial presentation of isolated gastric Crohn's disease and discuss the formidable diagnostic and therapeutic challenges encountered in such patients. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Urban drainage system planning and design--challenges with climate change and urbanization: a review.

    Science.gov (United States)

    Yazdanfar, Zeinab; Sharma, Ashok

    2015-01-01

    Urban drainage systems are in general failing in their functions mainly due to non-stationary climate and rapid urbanization. As these systems are becoming less efficient, issues such as sewer overflows and increase in urban flooding leading to surge in pollutant loads to receiving water bodies are becoming pervasive rapidly. A comprehensive investigation is required to understand these factors impacting the functioning of urban drainage, which vary spatially and temporally and are more complex when weaving together. It is necessary to establish a cost-effective, integrated planning and design framework for every local area by incorporating fit for purpose alternatives. Carefully selected adaptive measures are required for the provision of sustainable drainage systems to meet combined challenges of climate change and urbanization. This paper reviews challenges associated with urban drainage systems and explores limitations and potentials of different adaptation alternatives. It is hoped that the paper would provide drainage engineers, water planners, and decision makers with the state of the art information and technologies regarding adaptation options to increase drainage systems efficiency under changing climate and urbanization.

  5. Community-Based Disaster Risk Management in the Philippines: Achievements and Challenges of the Purok System

    Directory of Open Access Journals (Sweden)

    Angelina Matthies

    2017-06-01

    Full Text Available The purok system in the Philippines is promoted as a voluntary self-organization at the sub-village level which strengthens community resilience to natural hazards. In 2011, the system received the UN Sasakawa Award and gained prominence among the practitioner community. Based on a qualitative study in the municipality of San Francisco (Cebu province from December 2014 to March 2015, the article elaborates on the achievements and challenges of the purok system. Striking merits encompass efficient and effective information dissemination and evacuation measurements between all levels of political administration that stem from the system’s remarkable enforcement of human and social capital. This is underpinned by a clear determination of roles and responsibility that is subsumed under the concept of accountability. However, the purok system faces internal challenges of maintenance and implies profound conceptual ambiguities regarding the notion of voluntarism and capabilities that favor clientelism. Nevertheless, the purok system clearly distinguishes itself from conventional community-based disaster risk management practices and implies potentials that are highly beneficial for strengthening resilience in disaster prone areas.

  6. Testing Challenges of Maritime Safety and Security Systems-of-Systems

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.; Gross, H.G.

    2008-01-01

    Preprint of paper published in: TAIC PART 2008: Testing: Academic & Industrial Conference, Practice and Research Techniques, 29-31 August 2008; doi:10.1109/TAIC-PART.2008.14 Maritime Safety and Security systems represent a novel kind of large-scale distributed component-based systems in which the

  7. The challenges of modulating the 'rest and digest' system: acetylcholine receptors as drug targets.

    Science.gov (United States)

    VanPatten, Sonya; Al-Abed, Yousef

    2017-01-01

    Acetylcholine, a major neurotransmitter of the parasympathetic and sympathetic nervous systems, was discovered in the early 1900s. Over the years, researchers have revealed much about its regulation, properties of its receptors and features of the downstream signaling that influence its terminal effects. The acetylcholine system, traditionally associated with neuromuscular communication, is now known to play a crucial part in modulation of the immune system and other 'rest and digest' effects. Recent research seeks to elucidate the system's role in brain functions including cognition, sleep, arousal, motivation, reward and pain. We highlight clinically approved and experimental drugs that modulate the acetylcholine receptors. The complexities in targeting the acetylcholine receptors are vast and finding future indications for drug development associated with specific acetylcholine receptors remains a challenge. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Embedded and real-time vehicle detection system for challenging on-road scenes

    Science.gov (United States)

    Gu, Qin; Yang, Jianyu; Kong, Lingjiang; Yan, Wei Qi; Klette, Reinhard

    2017-06-01

    Vehicle detection is an important topic for advanced driver-assistance systems. This paper proposes an adaptive approach for an embedded system by focusing on monocular vehicle detection in real time, also aiming at being accurate under challenging conditions. Scene classification is accomplished by using a simplified convolution neural network with hypothesis generation by SoftMax regression. The output is consequently taken into account to optimize detection parameters for hypothesis generation and testing. Thus, we offer a sample-reorganization mechanism to improve the performance of vehicle hypothesis verification. A hypothesis leap mechanism is in use to improve the operating efficiency of the on-board system. A practical on-road test is employed to verify vehicle detection (i.e., accuracy) and also the performance of the designed on-board system regarding speed.

  9. Fall Prediction and Prevention Systems: Recent Trends, Challenges, and Future Research Directions

    Directory of Open Access Journals (Sweden)

    Ramesh Rajagopalan

    2017-11-01

    Full Text Available Fall prediction is a multifaceted problem that involves complex interactions between physiological, behavioral, and environmental factors. Existing fall detection and prediction systems mainly focus on physiological factors such as gait, vision, and cognition, and do not address the multifactorial nature of falls. In addition, these systems lack efficient user interfaces and feedback for preventing future falls. Recent advances in internet of things (IoT and mobile technologies offer ample opportunities for integrating contextual information about patient behavior and environment along with physiological health data for predicting falls. This article reviews the state-of-the-art in fall detection and prediction systems. It also describes the challenges, limitations, and future directions in the design and implementation of effective fall prediction and prevention systems.

  10. Passive sensing and imaging for GIS-PMS: system concept and challenges

    Science.gov (United States)

    Boyajian, D.; Chung, H.; Chen, S. E.

    2008-03-01

    A GIS-based data management system has been proposed for pavement management due to the spatial capability in organizing diverse geo-referenced information. The technology can be further enhanced by nondestructive distributed sensing. To target a wide study area, this research proposes a low-cost vibro-acousto passive sensing technique that embeds within roadways for long-term sensing. Using self-sustaining MEM sensors, the technology detects acoustic signals and use relative rating to assess pavement conditions. The detection technique echoes the traditional chain-drag technology in that the same sound detection is deployed. Coupling with previously established AMPIS pavement imaging and distress detection technique, the proposed system can evolve to be a more powerful new-generation GIS-PMS. This paper introduces the system concept and describes the philosophy behind the system and some of the challenges that we are currently attempting to solve.

  11. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

    Science.gov (United States)

    Vaquero, Juan José; Kinahan, Paul

    2017-01-01

    Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges. PMID:26643024

  12. The deployed medical director: managing the challenges of a complex trauma system.

    Science.gov (United States)

    Mahoney, P F; Hodgetts, T J; Hicks, I

    2011-09-01

    Contemporary combat casualty care has never been more sophisticated or effective, which is matched by an unprecedented level of clinical complexity. The management of this complexity has demanded the evolution of a more direct clinical leadership model in the field hospital: the Deployed Medical Director (DMD). The DMD has a central co-ordinating role in reducing the friction generated by individuals' unfamiliarity in a rapidly developing clinical environment that has diverged from the NHS; in cementing interoperability within a multinational medical treatment facility working at high intensity; and in maintaining and developing the highest clinical standards within the deployed trauma system. This article describes the evolution of the DMD role and illustrates the challenges through a series of vignettes. Particular emphasis is given to the organisational risk that the role carries through necessary ethical choices, the requirement to integrate multi-national cultural differences and the challenge of dealing with interpersonal frictions amongst senior staff.

  13. u-Healthcare system: state-of-the-art review and challenges.

    Science.gov (United States)

    Touati, Farid; Tabish, Rohan

    2013-06-01

    With the increase of an ageing population and chronic diseases, society becomes more health conscious and patients become "health consumers" looking for better health management. People's perception is shifting towards patient-centered, rather than the classical, hospital-centered health services which has been propelling the evolution of telemedicine research from the classic e-Health to m-Health and now is to ubiquitous healthcare (u-Health). It is expected that mobile & ubiquitous Telemedicine, integrated with Wireless Body Area Network (WBAN), have a great potential in fostering the provision of next-generation u-Health. Despite the recent efforts and achievements, current u-Health proposed solutions still suffer from shortcomings hampering their adoption today. This paper presents a comprehensive review of up-to-date requirements in hardware, communication, and computing for next-generation u-Health systems. It compares new technological and technical trends and discusses how they address expected u-Health requirements. A thorough survey on various worldwide recent system implementations is presented in an attempt to identify shortcomings in state-of-the art solutions. In particular, challenges in WBAN and ubiquitous computing were emphasized. The purpose of this survey is not only to help beginners with a holistic approach toward understanding u-Health systems but also present to researchers new technological trends and design challenges they have to cope with, while designing such systems.

  14. Computer-Aided Diagnosis Systems for Lung Cancer: Challenges and Methodologies

    Directory of Open Access Journals (Sweden)

    Ayman El-Baz

    2013-01-01

    Full Text Available This paper overviews one of the most important, interesting, and challenging problems in oncology, the problem of lung cancer diagnosis. Developing an effective computer-aided diagnosis (CAD system for lung cancer is of great clinical importance and can increase the patient’s chance of survival. For this reason, CAD systems for lung cancer have been investigated in a huge number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This paper overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. For each technique, various aspects of technical issues, implemented methodologies, training and testing databases, and validation methods, as well as achieved performances, are described. In addition, the paper addresses several challenges that researchers face in each implementation step and outlines the strengths and drawbacks of the existing approaches for lung cancer CAD systems.

  15. The influence of social challenges when implementing information systems in a Swedish health-care organisation.

    Science.gov (United States)

    Nilsson, Lina; Eriksén, Sara; Borg, Christel

    2016-09-01

    To describe and obtain a deeper understanding of social challenges and their influence on the implementation process when implementing Information systems in a Swedish health-care organisation. Despite positive effects when implementing Information systems in health-care organisations, there are difficulties in the implementation process. Nurses' experiences of being neglected have been dismissed as reasons for setbacks in implementation. An Institutional Ethnography design was used. A deductive content analysis was made influenced by empirically identified social challenges of power, professional identity and encounters. An abstraction was made of the analysis. Nineteen nurses at macro, meso and micro levels were interviewed in focus groups. Organisational levels are lost in different ways in how to control the reformation, how to introduce Information systems as reformation strategies and in how to translate new tools and assumptions that do not fit traditional ways of working in shaping professional identities. Different focus may affect the reformation of health-care organisations and implementation and knowledge processes. An implementation climate is needed where the system standards fit the values of the users. Nursing management needs to be visionary, engaged and work with risk factors in order to reform the hierarchical health-care organisation. © 2016 John Wiley & Sons Ltd.

  16. The health and health system of South Africa: historical roots of current public health challenges.

    Science.gov (United States)

    Coovadia, Hoosen; Jewkes, Rachel; Barron, Peter; Sanders, David; McIntyre, Diane

    2009-09-05

    The roots of a dysfunctional health system and the collision of the epidemics of communicable and non-communicable diseases in South Africa can be found in policies from periods of the country's history, from colonial subjugation, apartheid dispossession, to the post-apartheid period. Racial and gender discrimination, the migrant labour system, the destruction of family life, vast income inequalities, and extreme violence have all formed part of South Africa's troubled past, and all have inexorably affected health and health services. In 1994, when apartheid ended, the health system faced massive challenges, many of which still persist. Macroeconomic policies, fostering growth rather than redistribution, contributed to the persistence of economic disparities between races despite a large expansion in social grants. The public health system has been transformed into an integrated, comprehensive national service, but failures in leadership and stewardship and weak management have led to inadequate implementation of what are often good policies. Pivotal facets of primary health care are not in place and there is a substantial human resources crisis facing the health sector. The HIV epidemic has contributed to and accelerated these challenges. All of these factors need to be addressed by the new government if health is to be improved and the Millennium Development Goals achieved in South Africa.

  17. Modelling of Multi-Agent Systems: Experiences with Membrane Computing and Future Challenges

    Directory of Open Access Journals (Sweden)

    Petros Kefalas

    2010-08-01

    Full Text Available Formal modelling of Multi-Agent Systems (MAS is a challenging task due to high complexity, interaction, parallelism and continuous change of roles and organisation between agents. In this paper we record our research experience on formal modelling of MAS. We review our research throughout the last decade, by describing the problems we have encountered and the decisions we have made towards resolving them and providing solutions. Much of this work involved membrane computing and classes of P Systems, such as Tissue and Population P Systems, targeted to the modelling of MAS whose dynamic structure is a prominent characteristic. More particularly, social insects (such as colonies of ants, bees, etc., biology inspired swarms and systems with emergent behaviour are indicative examples for which we developed formal MAS models. Here, we aim to review our work and disseminate our findings to fellow researchers who might face similar challenges and, furthermore, to discuss important issues for advancing research on the application of membrane computing in MAS modelling.

  18. Developing the Malaysian health system to meet the challenges of the future.

    Science.gov (United States)

    Merican, M I; Rohaizat, Y; Haniza, S

    2004-03-01

    The Malaysian health care system is a success story among countries of equivalent socio-economic status. However there are numerous challenges faced by the nation, which create the need for changes and reform. There is rising consumer demands and expectations for high technology and high cost medical care due to improved standards of living, changing disease patterns and demographic changes, inadequate integration of health services, maldistribution of resources and the threats as well as opportunities of globalisation and liberalisation. The changes in health policy, priorities and planning for the country are guided by the country's development policies, objectives and the challenges of Vision 2020, Vision for Health and the goals of the health system in ensuring universal access, improving equity and efficiency and the quality of life of the population. The essential services in the health system of the future are information and education of individuals to empower support for the wellness paradigm. There is also a need to restructure the national health care financing and the health care delivery system. The present roles and responsibilities of MOH also need to be reviewed.

  19. Next-Generation Climate Modeling Science Challenges for Simulation, Workflow and Analysis Systems

    Science.gov (United States)

    Koch, D. M.; Anantharaj, V. G.; Bader, D. C.; Krishnan, H.; Leung, L. R.; Ringler, T.; Taylor, M.; Wehner, M. F.; Williams, D. N.

    2016-12-01

    We will present two examples of current and future high-resolution climate-modeling research that are challenging existing simulation run-time I/O, model-data movement, storage and publishing, and analysis. In each case, we will consider lessons learned as current workflow systems are broken by these large-data science challenges, as well as strategies to repair or rebuild the systems. First we consider the science and workflow challenges to be posed by the CMIP6 multi-model HighResMIP, involving around a dozen modeling groups performing quarter-degree simulations, in 3-member ensembles for 100 years, with high-frequency (1-6 hourly) diagnostics, which is expected to generate over 4PB of data. An example of science derived from these experiments will be to study how resolution affects the ability of models to capture extreme-events such as hurricanes or atmospheric rivers. Expected methods to transfer (using parallel Globus) and analyze (using parallel "TECA" software tools) HighResMIP data for such feature-tracking by the DOE CASCADE project will be presented. A second example will be from the Accelerated Climate Modeling for Energy (ACME) project, which is currently addressing challenges involving multiple century-scale coupled high resolution (quarter-degree) climate simulations on DOE Leadership Class computers. ACME is anticipating production of over 5PB of data during the next 2 years of simulations, in order to investigate the drivers of water cycle changes, sea-level-rise, and carbon cycle evolution. The ACME workflow, from simulation to data transfer, storage, analysis and publication will be presented. Current and planned methods to accelerate the workflow, including implementing run-time diagnostics, and implementing server-side analysis to avoid moving large datasets will be presented.

  20. Building Applications, Opportunities and Challenges of Active Shading Systems: A State-of-the-Art Review

    Directory of Open Access Journals (Sweden)

    Joud Al Dakheel

    2017-10-01

    Full Text Available Active shading systems in buildings have emerged as a high performing shading solution that selectively and optimally controls daylight and heat gains. Active shading systems are increasingly used in buildings, due to their ability to mainly improve the building environment, reduce energy consumption and in some cases generate energy. They may be categorized into three classes: smart glazing, kinetic shading and integrated renewable energy shading. This paper reviews the current status of the different types in terms of design principle and working mechanism of the systems, performance, control strategies and building applications. Challenges, limitations and future opportunities of the systems are then discussed. The review highlights that despite its high initial cost, the electrochromic (EC glazing is the most applied smart glazing due to the extensive use of glass in buildings under all climatic conditions. In terms of external shadings, the rotating shading type is the predominantly used one in buildings due to its low initial cost. Algae façades and folding shading systems are still emerging types, with high initial and maintenance costs and requiring specialist installers. The algae façade systems and PV integrated shading systems are a promising solution due to their dual benefits of providing shading and generating electricity. Active shading systems were found to save 12 to 50% of the building cooling electricity consumption.

  1. A remote in-vessel and ex-vessel force-reflecting telerobotic system for the burning plasma experiment

    International Nuclear Information System (INIS)

    Kuban, D.P.; Busko, N.

    1992-01-01

    The Burning Plasma Experiment (BPX) has made an applaudable commitment to total remote maintenance which will undoubtedly move fusion energy closer to commercial reality. This commitment poses new and formidable challenges due to the dimensional constraints, diversity of maintenance operations, and the geometrically intricate equipment arrangements. These challenges must be addressed for successful hot operation of the Princeton Plasma Physics Laboratory BPX. This paper reports on a new manipulator system, called the TeleMate, which is under development to contribute to this needed capability. This system combines enhancements to a proven mechanical design with state-of-the-art controls technology, to produce a flexible system that can be configured to address the numerous remote fusion applications. The mechanical portion of the system has many years of operation in existing radioactive facilities. This paper presents a system description, the development status, initial test data, and control system performance

  2. U.S. Experiences in Tackling Energy and Environmental Challenges of Boiler System

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lu, Hongyou [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Price, Lynn K. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-08-15

    In the U.S., energy consumption by steam and process heat combined accounts for over 50% of the total energy use from industrial systems (see Figure 1). The use of boilers, process heaters, and furnaces for generating steam and heat in industrial facilities, commercial settings, and institutions consumes significant amounts of energy and is one of major sources of hazardous air pollutants, which contribute significantly to local pollution and global climate change. To address the energy and environmental challenges caused by boiler systems in the U.S., the country has taken a series of actions to reduce emissions from industrial, commercial and institutional boilers, improve the efficiency of steam systems, replace coal with cleaner energy resources, and promote the wider use of combined heat and power (CHP).

  3. [Primary malignant melanoma of the central nervous system: A diagnostic challenge].

    Science.gov (United States)

    Quillo-Olvera, Javier; Uribe-Olalde, Juan Salvador; Alcántara-Gómez, Leopoldo Alberto; Rejón-Pérez, Jorge Dax; Palomera-Gómez, Héctor Guillermo

    2015-01-01

    The rare incidence of primary malignant melanoma of the central nervous system and its ability to mimic other melanocytic tumors on images makes it a diagnostic challenge for the neurosurgeon. A 51-year-old patient, with a tumor located in the right forniceal callosum area. Total surgical excision was performed. Histopathological result was consistent with the diagnosis of primary malignant melanoma of the central nervous system, after ruling out extra cranial and extra spinal melanocytic lesions. The primary malignant melanoma of the central nervous system is extremely rare. There are features in magnetic resonance imaging that increase the diagnostic suspicion; nevertheless there are other tumors with more prevalence that share some of these features through image. Since there is not an established therapeutic standard its prognosis is discouraging. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  4. The implementation of mental health information systems in developing countries: challenges and opportunities.

    Science.gov (United States)

    Ndetei, David M; Jenkins, Rachel

    2009-01-01

    The aims are to examine the challenges and opportunities in the implementation of mental health information systems (MHIS) in developing countries as suggested by the World Health Organization (WHO) and explored by Gulbinat et al. (2008). Special recommendations for developing countries are: 1) MHIS should be linked to the general medical information system; 2) there is need for adoption, adaptation and validation of preferably self-administered instruments that are appropriate for different levels within the health care system; 3) developing countries must adopt innovative and "unconventional" approaches through utilization of community members, traditional doctors/healers and mid-cadre health workers, in addition to general doctors, for the delivery of mental health services.

  5. Adaptation and Implementation of a Science-Based Prevention System in Colombia: Challenges and Achievements

    Science.gov (United States)

    Pérez-Gómez, Augusto; Mejía-Trujillo, Juliana; Brown, Eric C.; Eisenberg, Nicole

    2016-01-01

    During the last 2 years, the Colombian government and the Nuevos Rumbos Corporation have been implementing an adapted version of the Communities That Care (CTC) prevention system, called Comunidades Que se Cuidan (CQC) in Spanish, for use in Colombia. This brief report presents the process of implementing CQC and identifies some of the main challenges and achievements of implementing the system in eight communities in Colombia. Preliminary results of a pilot study of CQC implementation in Colombia show that prevention system development, including a focus on measuring community risk and protection, can be established successfully in Latin American communities despite a lack of rigorously tested prevention programs and strategies. Moreover, mobilizing community coalitions toward science-based prevention, with a focus on examining local risk and protective factor data, can spur development and evaluation of prevention efforts in Latin America. PMID:28154437

  6. Cloud Based Educational Systems 
And Its Challenges And Opportunities And Issues

    Directory of Open Access Journals (Sweden)

    Prantosh Kr. PAUL

    2014-01-01

    Full Text Available Cloud Computing (CC is actually is a set of hardware, software, networks, storage, services an interface combines to deliver aspects of computing as a service. Cloud Computing (CC actually uses the central remote servers to maintain data and applications. Practically Cloud Computing (CC is extension of Grid computing with independency and smarter tools and technological gradients. Healthy Cloud Computing helps in sharing of software, hardware, application and other packages with the help of internet tools and wireless media. Cloud Computing, has benefits in several field and applications domain such as Agriculture, Business and Commerce, Health Care, Hospitality and Tourism, Education and Training sector and so on. In Education Systems, it may be applicable in general regular education and other education systems including general and vocational training. This paper is talks about opportunities that provide Cloud Computing (CC; however the intention would be challenges and issues in relation to Education, Education Systems and Training programme.

  7. Mechatronic futures challenges and solutions for mechatronic systems and their designers

    CERN Document Server

    Bradley, David

    2016-01-01

    Offering a comprehensive overview of the challenges, risks and options facing the future of mechatronics, this book provides insights into how these issues are currently assessed and managed. Building on the previously published book ‘Mechatronics in Action,’ it identifies and discusses the key issues likely to impact on future mechatronic systems. It supports mechatronics practitioners in identifying key areas in design, modeling and technology and places these in the wider context of concepts such as cyber-physical systems and the Internet of Things. For educators it considers the potential effects of developments in these areas on mechatronic course design, and ways of integrating these. Written by experts in the field, it explores topics including systems integration, design, modeling, privacy, ethics and future application domains. Highlighting novel innovation directions, it is intended for academics, engineers and students working in the field of mechatronics, particularly those developing new conc...

  8. Challenges in legislation, recycling system and technical system of waste electrical and electronic equipment in China.

    Science.gov (United States)

    Zhang, Shengen; Ding, Yunji; Liu, Bo; Pan, De'an; Chang, Chein-chi; Volinsky, Alex A

    2015-11-01

    Waste electrical and electronic equipment (WEEE) has been one of the fastest growing waste streams worldwide. Effective and efficient management and treatment of WEEE has become a global problem. As one of the world's largest electronic products manufacturing and consumption countries, China plays a key role in the material life cycle of electrical and electronic equipment. Over the past 20 years, China has made a great effort to improve WEEE recycling. Centered on the legal, recycling and technical systems, this paper reviews the progresses of WEEE recycling in China. An integrated recycling system is proposed to realize WEEE high recycling rate for future WEEE recycling. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. The challenges of integrating multiple safeguards systems in a large nuclear facility

    International Nuclear Information System (INIS)

    Lavietes, A.; Liguori, C.; Pickrell, M.; Plenteda, R.; Sweet, M.

    2009-01-01

    Full-text: Implementing safeguards in a cost-effective manner in large nuclear facilities such as fuel conditioning, fuel reprocessing, and fuel fabrication plants requires the extensive use of instrumentation that is operated in unattended mode. The collected data is then periodically reviewed by the inspectors either on-site at a central location in the facility or remotely in the IAEA offices. A wide variety of instruments are deployed in large facilities, including video surveillance cameras, electronic sealing devices, non-destructive assay systems based on gamma ray and neutron detection, load cells for mass measurement, ID-readers, and other process-specific monitors. The challenge to integrate these different measurement instruments into an efficient, reliable, and secure system requires implementing standardization at various levels throughout the design process. This standardization includes the data generator behaviour and interface, networking solutions, and data security approaches. This standardization will provide a wide range of savings, including reduced training for inspectors and technicians, reduced periodic technical maintenance, reduced spare parts inventory, increased system robustness, and more predictive system behaviour. The development of standard building blocks will reduce the number of data generators required and allow implementation of simplified architectures that do not require local collection computers but rather utilize transmission of the acquired data directly to a central server via Ethernet connectivity. This approach will result in fewer system components and therefore reduced maintenance efforts and improved reliability. This paper discusses in detail the challenges and the subsequent solutions in the various areas that the IAEA Department of Safeguards has committed to pursue as the best sustainable way of maintaining the ability to implement reliable safeguards systems. (author)

  10. Overcoming the Challenges of Implementing a Multi-Mission Distributed Workflow System

    Science.gov (United States)

    Sayfi, Elias; Cheng, Cecilia; Lee, Hyun; Patel, Rajesh; Takagi, Atsuya; Yu, Dan

    2009-01-01

    A multi-mission approach to solving the same problems for various projects is enticing. However, the multi-mission approach leads to the need to develop a configurable, adaptable and distributed system to meet unique project requirements. That, in turn, leads to a set of challenges varying from handling synchronization issues to coming up with a smart design that allows the "unknowns" to be decided later. This paper discusses the challenges that the Multi-mission Automated Task Invocation Subsystem (MATIS) team has come up against while designing the distributed workflow system, as well as elaborates on the solutions that were implemented. The first is to design an easily adaptable system that requires no code changes as a result of configuration changes. The number of formal deliveries is often limited because each delivery costs time and money. Changes such as the sequence of programs being called, a change of a parameter value in the program that is being automated should not result in code changes or redelivery.

  11. Data Mining for Wearable Sensors in Health Monitoring Systems: A Review of Recent Trends and Challenges

    Directory of Open Access Journals (Sweden)

    Hadi Banaee

    2013-12-01

    Full Text Available The past few years have witnessed an increase in the development of wearable sensors for health monitoring systems. This increase has been due to several factors such as development in sensor technology as well as directed efforts on political and stakeholder levels to promote projects which address the need for providing new methods for care given increasing challenges with an aging population. An important aspect of study in such system is how the data is treated and processed. This paper provides a recent review of the latest methods and algorithms used to analyze data from wearable sensors used for physiological monitoring of vital signs in healthcare services. In particular, the paper outlines the more common data mining tasks that have been applied such as anomaly detection, prediction and decision making when considering in particular continuous time series measurements. Moreover, the paper further details the suitability of particular data mining and machine learning methods used to process the physiological data and provides an overview of the properties of the data sets used in experimental validation. Finally, based on this literature review, a number of key challenges have been outlined for data mining methods in health monitoring systems.

  12. A Primitive Memory System for Attention Deployments: Some Recent Challenges and Their Resolution

    Directory of Open Access Journals (Sweden)

    Árni Kristjánsson

    2011-05-01

    Full Text Available In the past my colleagues and I have presented evidence for the existence of a primitive memory for attention deployments. This memory system orients attention to features and locations of recent behavioral importance. A large part of the proposal is that the memory system facilitates attentional selection of features in the environment such as color, orientation, etc. I will review the findings behind these proposals. The bulk of this evidence comes from studies of history effects in vision, such as priming of visual search, and implicit learning in exogenously cued attention shifts. In addition, recent challenges to this view will be discussed (in particular, arguments that the facilitation from repetition in visual search tasks occurs at a relatively late stage of perceptual processing. Our recent investigations of these proposals suggest that there is indeed evidence for higher-level priming effects in visual search under certain conditions, but those findings do not challenge the basic proposals regarding the primitive memory system, since the evidence for feature-specific facilitation is robust.

  13. Challenges in network science: Applications to infrastructures, climate, social systems and economics

    Science.gov (United States)

    Havlin, S.; Kenett, D. Y.; Ben-Jacob, E.; Bunde, A.; Cohen, R.; Hermann, H.; Kantelhardt, J. W.; Kertész, J.; Kirkpatrick, S.; Kurths, J.; Portugali, J.; Solomon, S.

    2012-11-01

    Network theory has become one of the most visible theoretical frameworks that can be applied to the description, analysis, understanding, design and repair of multi-level complex systems. Complex networks occur everywhere, in man-made and human social systems, in organic and inorganic matter, from nano to macro scales, and in natural and anthropogenic structures. New applications are developed at an ever-increasing rate and the promise for future growth is high, since increasingly we interact with one another within these vital and complex environments. Despite all the great successes of this field, crucial aspects of multi-level complex systems have been largely ignored. Important challenges of network science are to take into account many of these missing realistic features such as strong coupling between networks (networks are not isolated), the dynamics of networks (networks are not static), interrelationships between structure, dynamics and function of networks, interdependencies in given networks (and other classes of links, including different signs of interactions), and spatial properties (including geographical aspects) of networks. This aim of this paper is to introduce and discuss the challenges that future network science needs to address, and how different disciplines will be accordingly affected.

  14. New capabilities in the HENP grand challenge storage access system and its application at RHIC

    International Nuclear Information System (INIS)

    Bernardo, L.; Gibbard, B.; Malon, D.; Nordberg, H.; Olson, D.; Porter, R.; Shoshani, A.; Sim, A.; Vaniachine, A.; Wenaus, T.; Wu, K.; Zimmerman, D.

    2000-01-01

    The High Energy and Nuclear Physics Data Access Grand Challenge project has developed an optimizing storage access software system that was prototyped at RHIC. It is currently undergoing integration with the STAR experiment in preparation for data taking that starts in mid-2000. The behavior and lessons learned in the RHIC Mock Data Challenge exercises are described as well as the observed performance under conditions designed to characterize scalability. Up to 250 simultaneous queries were tested and up to 10 million events across 7 event components were involved in these queries. The system coordinates the staging of ''bundles'' of files from the HPSS tape system, so that all the needed components of each event are in disk cache when accessed by the application software. The caching policy algorithm for the coordinated bundle staging is described in the paper. The initial prototype implementation interfaced to the Objectivity/DB. In this latest version, it evolved to work with arbitrary files and use CORBA interfaces to the tag database and file catalog services. The interface to the tag database and the MySQL-based file catalog services used by STAR are described along with the planned usage scenarios

  15. Phenotype prediction using regularized regression on genetic data in the DREAM5 Systems Genetics B Challenge.

    Directory of Open Access Journals (Sweden)

    Po-Ru Loh

    Full Text Available A major goal of large-scale genomics projects is to enable the use of data from high-throughput experimental methods to predict complex phenotypes such as disease susceptibility. The DREAM5 Systems Genetics B Challenge solicited algorithms to predict soybean plant resistance to the pathogen Phytophthora sojae from training sets including phenotype, genotype, and gene expression data. The challenge test set was divided into three subcategories, one requiring prediction based on only genotype data, another on only gene expression data, and the third on both genotype and gene expression data. Here we present our approach, primarily using regularized regression, which received the best-performer award for subchallenge B2 (gene expression only. We found that despite the availability of 941 genotype markers and 28,395 gene expression features, optimal models determined by cross-validation experiments typically used fewer than ten predictors, underscoring the importance of strong regularization in noisy datasets with far more features than samples. We also present substantial analysis of the training and test setup of the challenge, identifying high variance in performance on the gold standard test sets.

  16. Engineering challenges for instrumenting and controlling integrated organ-on-chip systems.

    Science.gov (United States)

    Wikswo, John P; Block, Frank E; Cliffel, David E; Goodwin, Cody R; Marasco, Christina C; Markov, Dmitry A; McLean, David L; McLean, John A; McKenzie, Jennifer R; Reiserer, Ronald S; Samson, Philip C; Schaffer, David K; Seale, Kevin T; Sherrod, Stacy D

    2013-03-01

    The sophistication and success of recently reported microfabricated organs-on-chips and human organ constructs have made it possible to design scaled and interconnected organ systems that may significantly augment the current drug development pipeline and lead to advances in systems biology. Physiologically realistic live microHuman (μHu) and milliHuman (mHu) systems operating for weeks to months present exciting and important engineering challenges such as determining the appropriate size for each organ to ensure appropriate relative organ functional activity, achieving appropriate cell density, providing the requisite universal perfusion media, sensing the breadth of physiological responses, and maintaining stable control of the entire system, while maintaining fluid scaling that consists of ~5 mL for the mHu and ~5 μL for the μHu. We believe that successful mHu and μHu systems for drug development and systems biology will require low-volume microdevices that support chemical signaling, microfabricated pumps, valves and microformulators, automated optical microscopy, electrochemical sensors for rapid metabolic assessment, ion mobility-mass spectrometry for real-time molecular analysis, advanced bioinformatics, and machine learning algorithms for automated model inference and integrated electronic control. Toward this goal, we are building functional prototype components and are working toward top-down system integration.

  17. From Playground to Salon: Challenges in Designing a System for Online Public Debate

    DEFF Research Database (Denmark)

    Løvlie, Anders Sundnes

    2017-01-01

    This article brings together two separate strands of media research: Online comments and media design. Online comments have long been a topic of much concern, both among scholars and the public at large, fearing negative effects from phenomena such as echo chambers, filter bubbles and hate speech....... This paper reports on a project by the Danish public service broadcaster Danmarks Radio, aiming to develop a system for online comments in line with the broadcaster's public service ideals. Through interviews and observations, I explore the challenges encountered by the project team as an empirical case...

  18. Facing the challenge of a changing system: training child welfare workers in a privatized environment.

    Science.gov (United States)

    Ortega, Debora M; Levy, Michelle M

    2002-01-01

    The state of Kansas' implementation of a privatized child welfare system is arguably an ambitious shift in child welfare service delivery. In an attempt to drastically improve services to vulnerable families, privatization resulted in intended and unintended consequences for the child welfare workforce. Some of these consequences, including the influx of inexperienced new workers, high worker turnover, and managing relationships with multiple partners, are issues that affect training needs of child welfare professionals. The following paper offers one approach to addressing these needs as well as identifying the challenges involved in training in a privatized environment.

  19. Communication for Change in the Challenge of Systemic Crisis. Latin American Perspective

    Directory of Open Access Journals (Sweden)

    Alejandro Barranquero

    2013-05-01

    Full Text Available The examination of the relationship between communication and development in a context of climate change and global systemic crisis challenges us to come to terms with the importance of the limits of human intervention on nature and against the logic of unlimited growth determined by modern and capitalist rationality. In this context, Latin America has usually played an influential and pioneering role in the questioning of development imaginaries from the dependency and participatory theories in the 60s and 70s and nowadays through the biocentric turn proposed by Living Well and other critical ecology perspectives.

  20. The regulatory control of radiation sources in Australia -- The challenges of a federal system

    International Nuclear Information System (INIS)

    Loy, J.; Colgan, P.

    2001-01-01

    The report refers to the challenges that Australia is facing, as a federal nation having a Commonwealth Government and six States and two territories, in establishing appropriate regulatory control of radiation sources. Information on the national inventory of radiation sources and existing regulatory infrastructure, including the system of notification, registration, licensing, inspection and enforcement, is explained in the report. The national provisions for the management of disused sources; the planning, preparedness and response to abnormal events and emergencies; the recovery of control over orphan sources; and education and training; are specifically emphasized. (author)

  1. Challenges and Specifications for Robust Face and Gait Recognition Systems for Surveillance Application

    Directory of Open Access Journals (Sweden)

    BUCIU Ioan

    2014-05-01

    Full Text Available Automated person recognition (APR based on biometric signals addresses the process of automatically recognize a person according to his physiological traits (face, voice, iris, fingerprint, ear shape, body odor, electroencephalogram – EEG, electrocardiogram, or hand geometry, or behavioural patterns (gait, signature, hand-grip, lip movement. The paper aims at briefly presenting the current challenges for two specific non-cooperative biometric approaches, namely face and gait biometrics as well as approaches that consider combination of the two in the attempt of a more robust system for accurate APR, in the context of surveillance application. Open problems from both sides are also pointed out.

  2. [Current challenges of external quality assurance in the German healthcare system].

    Science.gov (United States)

    Willms, Gerald; Bramesfeld, Anke; Pottkämper, Karen; Broge, Björn; Szecsenyi, Joachim

    2013-01-01

    External quality assurance has three main aims: to make service provision in medicine and nursing comparable, to systematically identify deficits in service quality and to support the introduction of measures for quality improvement. This article reflects on three major developments in mandatory external quality assurance in the German healthcare system that took place during the last five years. These developments include the implementation of cross-sectoral quality assurance, the utilisation of new data sources and a new focus on quality deficits and practicability. The article highlights the challenges that come along with these developments. Copyright © 2013. Published by Elsevier GmbH.

  3. Health system challenges in organizing quality diabetes care for urban poor in South India.

    Directory of Open Access Journals (Sweden)

    Upendra Bhojani

    Full Text Available BACKGROUND: Weak health systems in low- and middle-income countries are recognized as the major constraint in responding to the rising burden of chronic conditions. Despite recognition by global actors for the need for research on health systems, little attention has been given to the role played by local health systems. We aim to analyze a mixed local health system to identify the main challenges in delivering quality care for diabetes mellitus type 2. METHODS: We used the health system dynamics framework to analyze a health system in KG Halli, a poor urban neighborhood in South India. We conducted semi-structured interviews with healthcare providers located in and around the neighborhood who provide care to diabetes patients: three specialist and 13 non-specialist doctors, two pharmacists, and one laboratory technician. Observations at the health facilities were recorded in a field diary. Data were analyzed through thematic analysis. RESULT: There is a lack of functional referral systems and a considerable overlap in provision of outpatient care for diabetes across the different levels of healthcare services in KG Halli. Inadequate use of patients' medical records and lack of standard treatment protocols affect clinical decision-making. The poor regulation of the private sector, poor systemic coordination across healthcare providers and healthcare delivery platforms, widespread practice of bribery and absence of formal grievance redress platforms affect effective leadership and governance. There appears to be a trust deficit among patients and healthcare providers. The private sector, with a majority of healthcare providers lacking adequate training, operates to maximize profit, and healthcare for the poor is at best seen as charity. CONCLUSIONS: Systemic impediments in local health systems hinder the delivery of quality diabetes care to the urban poor. There is an urgent need to address these weaknesses in order to improve care for diabetes

  4. Health system challenges in organizing quality diabetes care for urban poor in South India.

    Science.gov (United States)

    Bhojani, Upendra; Devedasan, Narayanan; Mishra, Arima; De Henauw, Stefaan; Kolsteren, Patrick; Criel, Bart

    2014-01-01

    Weak health systems in low- and middle-income countries are recognized as the major constraint in responding to the rising burden of chronic conditions. Despite recognition by global actors for the need for research on health systems, little attention has been given to the role played by local health systems. We aim to analyze a mixed local health system to identify the main challenges in delivering quality care for diabetes mellitus type 2. We used the health system dynamics framework to analyze a health system in KG Halli, a poor urban neighborhood in South India. We conducted semi-structured interviews with healthcare providers located in and around the neighborhood who provide care to diabetes patients: three specialist and 13 non-specialist doctors, two pharmacists, and one laboratory technician. Observations at the health facilities were recorded in a field diary. Data were analyzed through thematic analysis. There is a lack of functional referral systems and a considerable overlap in provision of outpatient care for diabetes across the different levels of healthcare services in KG Halli. Inadequate use of patients' medical records and lack of standard treatment protocols affect clinical decision-making. The poor regulation of the private sector, poor systemic coordination across healthcare providers and healthcare delivery platforms, widespread practice of bribery and absence of formal grievance redress platforms affect effective leadership and governance. There appears to be a trust deficit among patients and healthcare providers. The private sector, with a majority of healthcare providers lacking adequate training, operates to maximize profit, and healthcare for the poor is at best seen as charity. Systemic impediments in local health systems hinder the delivery of quality diabetes care to the urban poor. There is an urgent need to address these weaknesses in order to improve care for diabetes and other chronic conditions.

  5. Challenges in the implementation of a quality management system applied to radiometric analysis

    International Nuclear Information System (INIS)

    Dias, Danila C.S.; Bonifacio, Rodrigo L.; Nascimento, Marcos R.L.; Silva, Nivaldo C. da; Taddei, Maria Helena T.

    2015-01-01

    The concept of quality in laboratories has been well established as an essential factor in the search for reliable results. Since its first version published (1999), the ISO/IEC 17025 has been applied in the industrial and research fields, in a wide range of laboratorial analyses. However, the implementation of a Quality Management System still poses great challenges to institutions and companies. The purpose of this work is to expose the constraints related to the implementation of ISO/IEC 17025 applied to analytical assays of radionuclides, accomplished by studying the case of the Pocos de Caldas Laboratory of the Brazilian Commission for Nuclear Energy. In this lab, a project of accreditation of techniques involving determination of radionuclides in water, soil, sediment and food samples has been conducted since 2011. The challenges presented by this project arise from the administrative view, where the governmental nature of the institution translates into unlevelled availability resources and the organizational view, whereas QMS requires inevitable changes in the organizational culture. It is important to point out that when it comes to accreditation of analysis involving radioactive elements, many aspects must be treated carefully due to the their very particular nature. Among these concerns are the determination of analysis uncertainties, accessibility to international proficiency studies, international radioactive samples and CRM transportation, the study of parameters on the validation of analytical methods and the lack of documentation and specialized personnel regarding quality at radiometric measurements. Through an effective management system, the institution is overcoming these challenges, moving toward the ISO/IEC 17025 accreditation. (author)

  6. Challenges in the implementation of a quality management system applied to radiometric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Danila C.S.; Bonifacio, Rodrigo L.; Nascimento, Marcos R.L.; Silva, Nivaldo C. da; Taddei, Maria Helena T., E-mail: danilacdias@gmail.com [Comissao Nacional de Energia Nuclear (LAPOC/CNEN-MG), Pocos de Caldas, MG (Brazil). Laboratorio de Pocos de Caldas

    2015-07-01

    The concept of quality in laboratories has been well established as an essential factor in the search for reliable results. Since its first version published (1999), the ISO/IEC 17025 has been applied in the industrial and research fields, in a wide range of laboratorial analyses. However, the implementation of a Quality Management System still poses great challenges to institutions and companies. The purpose of this work is to expose the constraints related to the implementation of ISO/IEC 17025 applied to analytical assays of radionuclides, accomplished by studying the case of the Pocos de Caldas Laboratory of the Brazilian Commission for Nuclear Energy. In this lab, a project of accreditation of techniques involving determination of radionuclides in water, soil, sediment and food samples has been conducted since 2011. The challenges presented by this project arise from the administrative view, where the governmental nature of the institution translates into unlevelled availability resources and the organizational view, whereas QMS requires inevitable changes in the organizational culture. It is important to point out that when it comes to accreditation of analysis involving radioactive elements, many aspects must be treated carefully due to the their very particular nature. Among these concerns are the determination of analysis uncertainties, accessibility to international proficiency studies, international radioactive samples and CRM transportation, the study of parameters on the validation of analytical methods and the lack of documentation and specialized personnel regarding quality at radiometric measurements. Through an effective management system, the institution is overcoming these challenges, moving toward the ISO/IEC 17025 accreditation. (author)

  7. The integration of renewable energy in the French electricity system: what challenges for optimization?

    International Nuclear Information System (INIS)

    Mathieu, Mathilde; Ruedinger, Andreas; Pescia, Dimitri

    2016-01-01

    Based on research reports and dialogue through expert seminars organized by IDDRI and Agora Energiewende in 2015, this Working Paper proposes a synthesis of the main challenges for the integration of renewable energies using an analysis of the electricity system and its potential for optimization over different time frames: the potential evolution of electricity systems at the regional and national levels in France between now and 2030; an analysis of the needs and options for flexibility services beyond production systems; the potential for optimization of instruments to encourage short-term integration in line with changes in regulation regarding RES support schemes. Achieving the targets for renewable energy development (RES-E) in France (40% share of the electricity consumption) and in Europe (approximately 50%) by 2030 poses new integration challenges. The successful transformation of the electricity system based on a significant renewable component requires a systemic approach which takes into account: the evolution of demand and supply (for electricity and all energy), the interactions and competition between flexibility options for system stabilization (interconnections, active demand-side management, storage), the development of relevant infrastructure and articulation between the technical system and market design. A forward-looking analysis of electricity systems helps to assess this increase in flexibility requirements while identifying several optimization options to facilitate RES integration, starting with regional coordination. France already has a flexible electricity system, thanks notably to its hydro potential. Even so, its evolution towards 40% RES by 2030 calls for some strategic choices. On the one hand, drawing up a long-term trajectory for the evolution of electricity demand - in terms of volume as well as the nature of needs addressed - seems essential to bring coherence to the evolution of the technology portfolio and to increase the

  8. The challenges of teaching geographical information systems integrated into the management of environment and natural resources

    International Nuclear Information System (INIS)

    Escobar, John; Betancur, Teresita; Palacio, Carlos

    2008-01-01

    The Geographic Information Systems, GIS, have the potential to become tools and methodologies for the solution of practical problems that involve complex spatial analyses, like the associated with natural resources and environmental management areas. The university, with its postgraduate programs, can help with the social adaptation processes for this new technology and can contribute to achieve the success sooner and with more effectiveness. To do so, three main challenges must be reached in the users of this technology: first, a spatial thinking second, skills to design and to make use of this instrument as supporting in environmental and natural resources analyses and finally, the identification of strategies to use this technology in projects and corporative surroundings. The Antioquia University in its Engineering Faculty (at first, in agreement with the Education Faculty)developed a Specialization in Environment and Geoinformatic. In this, the curriculum is worked in three moments (one for each challenge): first, a moment to building a common language and to adopting conceptual and technical instruments? second, a moment to put together instruments and methods and finally, a moment to make the practical application of the environmental management supported in the geo information spatial systems. This article gives account of this institutional experience.

  9. Chikungunya in the region of the Americas. A challenge for rheumatologists and health care systems.

    Science.gov (United States)

    Pineda, Carlos; Muñoz-Louis, Roberto; Caballero-Uribe, Carlo V; Viasus, Diego

    2016-10-01

    At the end of 2013, the Pan American Health Organization issued an epidemiological alert due to the detection of the first local cases of Chikungunya in the Americas. By August 2015, autochthonous transmissions were detected in 33 countries and territories of the Americas. Latin America has reported nearly one million cases; only Colombia has issued a report of >200,000 cases during the first 4 months of 2015. In some Latin American and Caribbean countries, Chikungunya becomes a major public health problem. The disease commonly exhibits a self-limited course of arthritis, usually lasting for a few days or that may be prolonged to weeks; however, in 10-60 % of cases, joint pain may become chronic and persist for up to 3-5 years. Human-caused environmental changes, such as climate change, the globalization of international exchange, and disordered urban growth, are some factors that aid in its emergence and dissemination. Outbreaks of Chikungunya comprise a challenge for health care systems and rheumatologists because of the high attack rate on the population and the anticipated development of post-Chikungunya chronic rheumatism. This review emphasizes the rheumatologic clinical manifestations reported in the American continent and highlights the challenges that health care systems face in the absence of an effective vaccine and specific treatment to fight Chikungunya.

  10. Multi -omics and metabolic modelling pipelines: challenges and tools for systems microbiology.

    Science.gov (United States)

    Fondi, Marco; Liò, Pietro

    2015-02-01

    Integrated -omics approaches are quickly spreading across microbiology research labs, leading to (i) the possibility of detecting previously hidden features of microbial cells like multi-scale spatial organization and (ii) tracing molecular components across multiple cellular functional states. This promises to reduce the knowledge gap between genotype and phenotype and poses new challenges for computational microbiologists. We underline how the capability to unravel the complexity of microbial life will strongly depend on the integration of the huge and diverse amount of information that can be derived today from -omics experiments. In this work, we present opportunities and challenges of multi -omics data integration in current systems biology pipelines. We here discuss which layers of biological information are important for biotechnological and clinical purposes, with a special focus on bacterial metabolism and modelling procedures. A general review of the most recent computational tools for performing large-scale datasets integration is also presented, together with a possible framework to guide the design of systems biology experiments by microbiologists. Copyright © 2015. Published by Elsevier GmbH.

  11. Challenges at the interface of working between mental health services and the criminal justice system.

    Science.gov (United States)

    Hean, Sarah; Warr, Jerry; Staddon, Sue

    2009-07-01

    Provision of mental health reports for defendants in contact with the criminal justice system is problematic. This paper explores factors that facilitate the flow of information on a defendant between the courts and the mental health services. It identifies key challenges to this information transfer from a court worker's perspective. It also explores potential mismatches in the expectations held by the criminal justice system and the mental health services of the timeframes in which reports should be delivered and examines the perceived usefulness of reports. In Part 1, questionnaires were distributed to a population of 2107 court workers. In Part 2, monitoring forms were completed by court and health professionals on each report request made over a seven month period. Three key challenges to information transfer were identified: delays in report production, perceived inadequacies in the report content and report funding. Perceived timelines within which respondents believed reports should be delivered varied and there is a mismatch between the expectations of the two services. Perceptions on the usefulness of court reports also varied. Poor inter-agency communications are caused by lack of a clear, shared protocol outlining agreed timelines, report content and lines of responsibility relating to resource provision. Clear service level agreements are required between services to achieve clarity.

  12. RAVONSICS-challenging for assuring software reliability of nuclear I and C system

    International Nuclear Information System (INIS)

    Hai Zeng; Ming Yang; Yoshikawa, Hidekazu

    2015-01-01

    As the “central nerve system”, the highly reliable Instrumentation and Control (I and C) systems, which provide the right functions and functions correctly, are always desirable not only for the end users of NPPs but also the suppliers of I and C systems. The Digitalization of nuclear I and C system happened in recent years brought a lot of new features for nuclear I and C system. On one side digital technology provides more functionalities, and it should be more reliable and robust; on the other side, digital technology brings new challenge for nuclear I and C system, especially the software running in the hardware component. The software provides flexible functionalities for nuclear I and C system, but it also brings the difficulties to evaluate the reliability and safety of it because of the complexity of software. The reliability of software, which is indispensable part of I and C system, will have essential impact on the reliability of the whole system, and people definitely want to know what the reliability of this intangible part is. The methods used for the evaluation of reliability of system and hardware hardly work for software, because the inherent difference of failure mechanism exists between software and hardware. Failure in software is systematically induced by design error, but failure in hardware is randomly induced by material and production. To continue the effort on this hot topic and to try to achieve consensus on the potential methodology for software reliability evaluation, a cooperative research project called RAVONSICS (Reliability and Verification and Validation of Nuclear Safety I and C Software) is being carried on by 7 Chinese partners, which includes University, research institute, utility, vendor, and safety regulatory body. The objective of RAVONSICS is to bring forwards the methodology for the software reliability evaluation, and the software verification technique. RAVONSICS works cooperatively with its European sister project

  13. Unmanned Aerial Aircraft Systems for transportation engineering: Current practice and future challenges

    Directory of Open Access Journals (Sweden)

    Emmanouil N. Barmpounakis

    2016-10-01

    Full Text Available Acquiring and processing video streams from static cameras has been proposed as one of the most efficient tools for visualizing and gathering traffic information. With the latest advances in technology and visual media, combined with the increased needs in dealing with congestion more effectively and directly, the use of Unmanned Aerial Aircraft Systems (UAS has emerged in the field of traffic engineering. In this paper, we review studies and applications that incorporate UAS in transportation research and practice with the aim to set the grounds from the proper understanding and implementation of UAS related surveillance systems in transportation and traffic engineering. The studies reviewed are categorized in different transportation engineering areas. Additional significant applications from other research fields are also referenced to identify other promising applications. Finally, issues and emerging challenges in both a conceptual and methodological level are revealed and discussed.

  14. Non-communicable disease prevention in Nepal: systemic challenges and future directions.

    Science.gov (United States)

    Sharma, Sudesh Raj; Page, Rachel; Matheson, Anna; Lambrick, Danielle; Faulkner, James; Mishra, Shiva Raj

    2017-08-01

    Developing countries such as Nepal are experiencing a double burden of communicable and non-communicable diseases (NCDs) resulting in social and economic losses. In Nepal, more than half of the disease burden is due to NCDs. The major NCDs in Nepal are cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. Behavioural factors such as tobacco use, alcohol consumption, physical inactivity and unhealthy diet are driving the epidemic of NCDs, which are further influenced by social, economic and environmental determinants. The health system of Nepal has not been able to address the ever-increasing burden of NCDs. With the formulation of the Multisectoral Action Plan for Prevention and Control of NCDs 2014-2020, there has been some hope for tackling the NCDs and their social determinants in Nepal through a primary prevention approach. This paper discusses the systemic challenges and recommends two key actions for the prevention and control of NCDs in Nepal.

  15. Toward an Integrated Competence-Based System Supporting Lifelong Learning and Employability: Concepts, Model, and Challenges

    Science.gov (United States)

    Miao, Yongwu; van der Klink, Marcel; Boon, Jo; Sloep, Peter; Koper, Rob

    Efficient and effective lifelong learning requires that people can make informed decisions about their continuous personal development in the different stages of their life. In this paper we state that lifelong learners need to be characterized as decision-makers. In order to improve the quality of their decisions, we propose the development of an integrated lifelong learning and employment support system, which traces learners’ competence development and provides a decision support environment. An abstract conceptual model has been developed and the main design ideas have been documented using Z notation. Moreover, we analyzed the main technical challenges for the realization of the target system: competence information fusion, decision analysis models, spatial indexing structures and browsing structures and visualization of competence-related information objects.

  16. Challenges in Gaining Large Scale Carbon Reductions through Wireless Home Automation Systems

    DEFF Research Database (Denmark)

    Larsen, Peter Gorm; Rovsing, Poul Ejnar; Toftegaard, Thomas Skjødeberg

    2010-01-01

    Buildings account for more than a 35 % of the energy consumption in Europe. Therefore a step towards more sustainable lifestile is to use home automation to optimize the energy consumption “automatically”. This paper reports about the usage and some of the remaining challenges of especially...... wireless but also powerline communication in a home automation setting. For many years, home automation has been visible to many, but accessible to only a few, because of inadequate integration of systems. A vast number of both standard and proprietary communication protocols are used, and systems...... are often difficult to install and configure so professional assistance is needed. In this paper we report about our experience in constructing an open universal home automation framework enabling interoperability of multiple communication protocols. The framework can easily be expanded in order to support...

  17. When health systems are barriers to health care: challenges faced by uninsured Mexican kidney patients.

    Science.gov (United States)

    Kierans, Ciara; Padilla-Altamira, Cesar; Garcia-Garcia, Guillermo; Ibarra-Hernandez, Margarita; Mercado, Francisco J

    2013-01-01

    Chronic Kidney Disease disproportionately affects the poor in Low and Middle Income Countries (LMICs). Mexico exemplifies the difficulties faced in supporting Renal Replacement Therapy (RRT) and providing equitable patient care, despite recent attempts at health reform. The objective of this study is to document the challenges faced by uninsured, poor Mexican families when attempting to access RRT. The article takes an ethnographic approach, using interviewing and observation to generate detailed accounts of the problems that accompany attempts to secure care. The study, based in the state of Jalisco, comprised interviews with patients, their caregivers, health and social care professionals, among others. Observations were carried out in both clinical and social settings. In the absence of organised health information and stable pathways to renal care, patients and their families work extraordinarily hard and at great expense to secure care in a mixed public-private healthcare system. As part of this work, they must navigate challenging health and social care environments, negotiate treatments and costs, resource and finance healthcare and manage a wide range of formal and informal health information. Examining commonalities across pathways to adequate healthcare reveals major failings in the Mexican system. These systemic problems serve to reproduce and deepen health inequalities. A system, in which the costs of renal care are disproportionately borne by those who can least afford them, faces major difficulties around the sustainability and resourcing of RRTs. Attempts to increase access to renal therapies, therefore, need to take into account the complex social and economic demands this places on those who need access most. This paper further shows that ethnographic studies of the concrete ways in which healthcare is accessed in practice provide important insights into the plight of CKD patients and so constitute an important source of evidence in that effort.

  18. Evolution of health coverage in Mexico: evidence of progress and challenges in the Mexican health system.

    Science.gov (United States)

    Urquieta-Salomón, José E; Villarreal, Héctor J

    2016-02-01

    To consolidate an effective and efficient universal health care coverage requires a deep understanding of the challenges faced by the health care system in providing services demanded by population in need. This study analyses the dynamics of health insurance coverage and effective access coverage to some health interventions in Mexico. It examines the evolution of inequalities and heterogeneous performance of the insurance subsystems incorporated under the Mexican health care system. Two types of coverage indicators were selected: health insurance and effective access to preventive health interventions intended for normative population. Data were drawn from National Health and Nutrition Surveys 2006 and 2012. The economic inequality was estimated using the Standardized Concentration Index by household per capita consumption expenditure as socioeconomic-status indicator. Approximately 75% of the population reported being covered by one of the existing insurance schemes, representing a huge step forward from 2006, when as much as 51.62% of the population had no health insurance. About 87% of this growth was attributable to the expansion of Non Contributory Health Insurance whereas 7% emanated from the Social Security subsystem. The results revealed that inequality in access to health insurance was virtually eradicated; however, traces of unequal access persisted in some subpopulations groups. Coverage indicators of effective access showed a slight improvement in the period analysed, but prenatal care and interventions to prevent chronic disease still presented a serious shortage. Furthermore, there was no evidence that inequities in coverage of these interventions have decreased in recent years. The results provided a mixed picture, generalizable to the system as a whole, expansion of insurance status represents one of the most remarkable advances that have not been accompanied by a significant improvement in effective access. In addition, existing inequalities are

  19. When Health Systems Are Barriers to Health Care: Challenges Faced by Uninsured Mexican Kidney Patients

    Science.gov (United States)

    Kierans, Ciara; Padilla-Altamira, Cesar; Garcia-Garcia, Guillermo; Ibarra-Hernandez, Margarita; Mercado, Francisco J.

    2013-01-01

    Background Chronic Kidney Disease disproportionately affects the poor in Low and Middle Income Countries (LMICs). Mexico exemplifies the difficulties faced in supporting Renal Replacement Therapy (RRT) and providing equitable patient care, despite recent attempts at health reform. The objective of this study is to document the challenges faced by uninsured, poor Mexican families when attempting to access RRT. Methods The article takes an ethnographic approach, using interviewing and observation to generate detailed accounts of the problems that accompany attempts to secure care. The study, based in the state of Jalisco, comprised interviews with patients, their caregivers, health and social care professionals, among others. Observations were carried out in both clinical and social settings. Results In the absence of organised health information and stable pathways to renal care, patients and their families work extraordinarily hard and at great expense to secure care in a mixed public-private healthcare system. As part of this work, they must navigate challenging health and social care environments, negotiate treatments and costs, resource and finance healthcare and manage a wide range of formal and informal health information. Conclusions Examining commonalities across pathways to adequate healthcare reveals major failings in the Mexican system. These systemic problems serve to reproduce and deepen health inequalities. A system, in which the costs of renal care are disproportionately borne by those who can least afford them, faces major difficulties around the sustainability and resourcing of RRTs. Attempts to increase access to renal therapies, therefore, need to take into account the complex social and economic demands this places on those who need access most. This paper further shows that ethnographic studies of the concrete ways in which healthcare is accessed in practice provide important insights into the plight of CKD patients and so constitute an

  20. 3D-TV System with Depth-Image-Based Rendering Architectures, Techniques and Challenges

    CERN Document Server

    Zhao, Yin; Yu, Lu; Tanimoto, Masayuki

    2013-01-01

    Riding on the success of 3D cinema blockbusters and advances in stereoscopic display technology, 3D video applications have gathered momentum in recent years. 3D-TV System with Depth-Image-Based Rendering: Architectures, Techniques and Challenges surveys depth-image-based 3D-TV systems, which are expected to be put into applications in the near future. Depth-image-based rendering (DIBR) significantly enhances the 3D visual experience compared to stereoscopic systems currently in use. DIBR techniques make it possible to generate additional viewpoints using 3D warping techniques to adjust the perceived depth of stereoscopic videos and provide for auto-stereoscopic displays that do not require glasses for viewing the 3D image.   The material includes a technical review and literature survey of components and complete systems, solutions for technical issues, and implementation of prototypes. The book is organized into four sections: System Overview, Content Generation, Data Compression and Transmission, and 3D V...

  1. Emerging research in micro and nano systems: opportunities and challenges for societal impact

    Science.gov (United States)

    Gianchandani, Yogesh B.

    2010-02-01

    In just a few decades, micro and nano technologies have changed the way that we live - how we work and communicate; the food and medicine that we consume; the clothing that we use; and the entertainment that we seek. While these technologies are being actively investigated in several research communities, the potential for continued societal impact is constrained by resources available for system-level research. Given the long time-lines and levels of investment that are typically necessary to develop functional systems, strategic prioritization of research directions from the perspective of societal needs can be helpful. This paper outlines the findings of an NSF-sponsored road-mapping workshop that was held in 2009, with the intention of initiating a conversation about the opportunities and challenges for micro and nano systems. Four areas of need were discussed: environmental sensing; health care; infrastructure monitoring; and energy alternatives. Possible research trajectories were identified by envisioning technological goals for the year 2040, and linking these to horizons for 2015 and 2025. This paper also provides few examples of current research in each of the four application domains. It is noted that a systems perspective can help to keep the research focused, accelerating and amplifying the societal gain with available resources. Practical and affordable solutions at the system level will require partnerships between specialists, and also between academia and industry.

  2. The Challenges Associated with Accounting for the Army's Force Provider (FP) System when Deployed in Support of Military Operations

    National Research Council Canada - National Science Library

    Correia, Carlos A; Horner, Allen; McLaughlin, James; Stewardson, Donald

    2008-01-01

    .... The analysis will address the inherent challenges associated with accountability of the FP System when deployed and decommissioned to undergo RESET, the lack of a singular management and decision...

  3. Costs and epidemiological changes of chronic diseases: implications and challenges for health systems.

    Science.gov (United States)

    Arredondo, Armando; Aviles, Raul

    2015-01-01

    The need to integrate economic and epidemiological aspects in the clinical perspective leads to a proposal for the analysis of health disparities and to an evaluation of the health services and of the new challenges which are now being faced by health system reforms in middle income countries. To identify the epidemiological changes, the demand for health services and economic burden from chronic diseases (diabetes and hypertension) in a middle income county. We conducted longitudinal analyses of costs and epidemiological changes for diabetes and hypertension in the Mexican health system. The study population included both the insured and uninsured populations. The cost-evaluation method was used, based on the instrumentation and consensus techniques. To estimate the epidemiological changes and financial consequences for 2014-2016, six models were constructed according to the Box-Jenkins technique, using confidence intervals of 95%, and the Box-Pierce test. Regarding epidemiological changes expected in both diseases for 2014 vs. 2016, an increase is expected, although results predict a greater increase for diabetes, 8-12% in all three studied institutions, (p management per patient in the case of diabetes, and from $485 to $622 in patients with hypertension. Comparing financial consequences of health services required by insured and uninsured populations, the greater increase (23%) will be for the insured population (p financial requirements of both diseases will amount to 19.5% of the total budget for the uninsured and 12.5% for the insured population. If the risk factors and the different health care models remain as they currently are, the economic impact of expected epidemiological changes on the social security system will be particularly strong. Another relevant challenge is the appearance of internal competition in the use and allocation of financial resources with programs for other chronic and infectious diseases.

  4. Integration of community health workers into health systems in developing countries: Opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Collins Otieno Asweto

    2016-02-01

    Full Text Available Background: Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health workers (CHWs. It is imperative that health care systems focus on improving access to quality continuous primary care through the use of CHWs while paying attention to the factors that impact on CHWs and their effectiveness. Objective: To explore the possible opportunities and challenges of integrating CHWs into the health care systems of developing countries. Methods: Six databases were examined for quantitative, qualitative, and mixed-methods studies that included the integration of CHWs, their motivation and supervision, and CHW policy making and implementation in developing countries. Thirty-three studies met the inclusion criteria and were double read to extract data relevant to the context of CHW programs. Thematic coding was conducted and evidence on the main categories of contextual factors influencing integration of CHWs into the health system was synthesized. Results: CHWs are an effective and appropriate element of a health care team and can assist in addressing health disparities and social determinants of health. Important facilitators of integration of CHWs into health care teams are support from other health workers and inclusion of CHWs in case management meetings. Sustainable integration of CHWs into the health care system requires the formulation and implementation of polices that support their work, as well as financial and nonfinancial incentives, motivation, collaborative and supportive supervision, and a manageable workload. Conclusions: For sustainable integration of CHWs into health care systems, high-performing health systems with sound governance, adequate financing, well-organized service delivery, and adequate supplies and equipment are essential. Similarly, competent communities could contribute to better CHW performance through sound

  5. Development of oral food-grade delivery systems: current knowledge and future challenges.

    Science.gov (United States)

    Benshitrit, Revital Cohen; Levi, Carmit Shani; Tal, Sharon Levi; Shimoni, Eyal; Lesmes, Uri

    2012-01-01

    In recent years there has been an increasing interest in the development of new and efficient oral food delivery systems as tools to prevent disease and promote human health and well-being. Such vehicles are sought to protect bioactive ingredients added to food while controlling and targeting their release as they pass through the human gastrointestinal tract (GIT). This review aims to summarize the key concepts of food delivery systems, their characterization and evaluation. Particularly, evaluation of their performance within the human GIT is discussed. To this end an overview of several in vivo and in vitro methods currently applied for the study of such systems is given. Although considered to be still in its infancy, this promising field of research is likely to infiltrate into real products through rational design. In order for such efforts to materialize into real products some challenges still need to be met and are discussed herein. Overall, it seems that adopting a comprehensive pharmacological approach and relevant cutting edge tools are likely to facilitate innovations and help elucidate and perhaps tailor delivery systems' behavior in the human GIT.

  6. LOCAL FOOD SYSTEMS DEVELOPMENT IN THE REPUBLIC OF MOLDOVA: CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Victor MOROZ

    2013-01-01

    Full Text Available The main challenge of the food sector in the Republic of Moldova is to identify specific needs and opportunities for agriculture and rural development throughout food supply chains, and focusing investment in areas where the most impact will be made. The identification and allocation of resources requires analysis of main dimensions of food supply chains, in order to establish links and determine local factors. In small transition economies the diagnosis of the food supply chains, is typically based on limited data and incomplete information. In order to investigate the actual state of food supply chains were used specific methods and techniques: statistical and economic analysis of macro-economic indicators, semi-structured interviews of key stakeholders, analysis of the impact of public policies on the agro-food sector. In the article is analyzed the process of food systems formation and integration at the local and global level. Although it is a small part of the overall agricultural sector, various local food systems are under development in the Republic of Moldova. These systems bring consumers in close contact with farmers and mobilize them to support local farms and sustainable farming practices. While local food systems continue to face many barriers, many of them show considerable potential for growth.

  7. Lead-Cooled Fast Reactor Systems and the Fuels and Materials Challenges

    Directory of Open Access Journals (Sweden)

    T. R. Allen

    2007-01-01

    Full Text Available Anticipated developments in the consumer energy market have led developers of nuclear energy concepts to consider how innovations in energy technology can be adapted to meet consumer needs. Properties of molten lead or lead-bismuth alloy coolants in lead-cooled fast reactor (LFR systems offer potential advantages for reactors with passive safety characteristics, modular deployment, and fuel cycle flexibility. In addition to realizing those engineering objectives, the feasibility of such systems will rest on development or selection of fuels and materials suitable for use with corrosive lead or lead-bismuth. Three proposed LFR systems, with varying levels of concept maturity, are described to illustrate their associated fuels and materials challenges. Nitride fuels are generally favored for LFR use over metal or oxide fuels due to their compatibility with molten lead and lead-bismuth, in addition to their high atomic density and thermal conductivity. Ferritic/martensitic stainless steels, perhaps with silicon and/or oxide-dispersion additions for enhanced coolant compatibility and improved high-temperature strength, might prove sufficient for low-to-moderate-temperature LFRs, but it appears that ceramics or refractory metal alloys will be necessary for higher-temperature LFR systems intended for production of hydrogen energy carriers.

  8. An overview of the challenges facing death investigation systems in certain resource limited countries.

    Science.gov (United States)

    Obenson, Ken; Enow Orock, George

    2017-08-01

    A properly operated death investigation system (DIS) serves multiple stakeholders. Law enforcement, public health departments and members of the public, benefit in various ways from the information that it provides. This information must be collected systematically and efficiently. The system must also be flexible enough to respond to pressures on its resources such as occurs during mass disasters. These obligations on a DIS require an investment of public money. However even in affluent Western countries the recent world economic crisis has led to a cut in spending on public services that affect both the healthcare system and services associated with death investigation. Although pathologists and other stake holders (judiciary, police, families) would like to see death investigations conducted to international standards, the fact is that policy makers in resource limited countries face additional population health and sociopolitical pressures which generally result in very little funding for the service. The purpose of this paper is to review some of the challenges that impede the proper functioning of a death investigation system in resource limited countries in Sub-Saharan Africa and the Caribbean. Possible solutions are discussed. Copyright © 2017. Published by Elsevier Ltd.

  9. Technological incorporation in the Unified Health System (SUS: the problem and ensuing challenges

    Directory of Open Access Journals (Sweden)

    Reinaldo Guimarães

    2014-12-01

    Full Text Available Technological incorporation is a central topic among the concerns regarding health care systems. This paper discusses the role of technology dynamics in health systems' cost increases, suggesting two different approaches - a 'pragmatic-economic' approach and a 'rational-defensive' approach - as guidelines to explain the reasons for this centrality. The paper shows how judicialization results from this situation and discusses two doctrinal views - 'reserve for contingencies' and 'rational use' - as the views that usually guide the debates in the courts and among health policy makers. The paper suggests that the attitude currently prevalent in the Brazilian judiciary system can prejudice the principle of equity by improperly evaluating the principle of integrality. We present a brief genealogy of HTA and a timeline of HTA in Brazil. We also discuss the relevance and the impact of Law 12401/2011, which regulates the principle of integrality in the Unified Health System (SUS and propose three challenges to the development of HTA actions aiming at technology incorporation in Brazil. Finally, we discuss the entry and the role of private health insurance companies, emphasizing changes in the scenario and in their position.

  10. [Market and public policy network failures: challenges and possibilities for the Brazilian Unified Health System].

    Science.gov (United States)

    Pinheiro Filho, Francisco Percival; Sarti, Flávia Mori

    2012-11-01

    The principles and guidelines of the Brazilian Unified Health System (SUS) impose a healthcare service structure based on public policy networks which, combined with the financing model adopted, leads to market failings. This imposes barriers to the management of the public health system and the enactment of SUS objectives. The institutional characteristics and the heterogeneity of players, allied to the existence of different healthcare approaches, generate analytical complexity in the study of the global dynamics of the SUS network. There are limitations in the use of quantitative methods based on static analysis of retrospective SUS data. Thus, an approach taking SUS as a complex system using innovative quantitative methodology based on computational simulation is proposed. This paper sought to analyze challenges and possibilities of the combined application of cellular automata modeling and agent-based modeling for simulation of the evolution of the SUS healthcare service network. This approach should permit better understanding of the organization, heterogeneity and structural dynamics of the SUS service network and a minimization of the effects of market failings on the Brazilian health system.

  11. Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Sarah R. [J. Craig Venter Inst., Rockville, MD (United States); Rodemeyer, Michael [Univ. of Virginia, Charlottesville, VA (United States); Garfinkel, Michele S. [EMBO, Heidelberg (Germany); Friedman, Robert M. [J. Craig Venter Inst., Rockville, MD (United States)

    2014-05-01

    Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options Sarah R. Carter, Ph.D., J. Craig Venter Institute; Michael Rodemeyer, J.D., University of Virginia; Michele S. Garfinkel, Ph.D., EMBO; Robert M. Friedman, Ph.D., J. Craig Venter Institute In recent years, a range of genetic engineering techniques referred to as “synthetic biology” has significantly expanded the tool kit available to scientists and engineers, providing them with far greater capabilities to engineer organisms than previous techniques allowed. The field of synthetic biology includes the relatively new ability to synthesize long pieces of DNA from chemicals, as well as improved methods for genetic manipulation and design of genetic pathways to achieve more precise control of biological systems. These advances will help usher in a new generation of genetically engineered microbes, plants, and animals. The JCVI Policy Center team, along with researchers at the University of Virginia and EMBO, examined how well the current U.S. regulatory system for genetically engineered products will handle the near-term introduction of organisms engineered using synthetic biology. In particular, the focus was on those organisms intended to be used or grown directly in the environment, outside of a contained facility. The study concludes that the U.S. regulatory agencies have adequate legal authority to address most, but not all, potential environmental, health and safety concerns posed by these organisms. Such near-term products are likely to represent incremental changes rather than a marked departure from previous genetically engineered organisms. However, the study also identified two key challenges for the regulatory system, which are detailed in the report. First, USDA’s authority over genetically engineered plants depends on the use of an older engineering technique that is no longer necessary for many applications. The shift to synthetic biology and other newer genetic

  12. Developing natural resource models using the object modeling system: feasibility and challenges

    Directory of Open Access Journals (Sweden)

    L. R. Ahuja

    2005-01-01

    Full Text Available Current challenges in natural resource management have created demand for integrated, flexible, and easily parameterized hydrologic models. Most of these monolithic models are not modular, thus modifications (e.g., changes in process representation require considerable time, effort, and expense. In this paper, the feasibility and challenges of using the Object Modeling System (OMS for natural resource model development will be explored. The OMS is a Java-based modeling framework that facilitates simulation model development, evaluation, and deployment. In general, the OMS consists of a library of science, control, and database modules and a means to assemble the selected modules into an application-specific modeling package. The framework is supported by data dictionary, data retrieval, GIS, graphical visualization, and statistical analysis utility modules. Specific features of the OMS that will be discussed include: 1 how to reduce duplication of effort in natural resource modeling; 2 how to make natural resource models easier to build, apply, and evaluate; 3 how to facilitate long-term maintainability of existing and new natural resource models; and 4 how to improve the quality of natural resource model code and ensure credibility of model implementations. Examples of integrating a simple water balance model and a large monolithic model into the OMS will be presented.

  13. Clinical decision support systems in hospital care using ubiquitous devices: Current issues and challenges.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Moqeem, Aasia A; Mirza, Farhaan; Lindén, Maria

    2017-11-01

    Supporting clinicians in decision making using advanced technologies has been an active research area in biomedical engineering during the past years. Among a wide range of ubiquitous systems, smartphone applications have been increasingly developed in healthcare settings to help clinicians as well as patients. Today, many smartphone applications, from basic data analysis to advanced patient monitoring, are available to clinicians and patients. Such applications are now increasingly integrating into healthcare for clinical decision support, and therefore, concerns around accuracy, stability, and dependency of these applications are rising. In addition, lack of attention to the clinicians' acceptability, as well as the low impact on the medical professionals' decision making, are posing more serious issues on the acceptability of smartphone applications. This article reviews smartphone-based decision support applications, focusing on hospital care settings and their overall impact of these applications on the wider clinical workflow. Additionally, key challenges and barriers of the current ubiquitous device-based healthcare applications are identified. Finally, this article addresses current challenges, future directions, and the adoption of mobile healthcare applications.

  14. Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.

    Science.gov (United States)

    Zhou, Zijian; Song, Jibin; Nie, Liming; Chen, Xiaoyuan

    2016-11-21

    The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, a photosensitizer (PS) and oxygen, which greatly favors the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) the limited penetration depth of light, which restricts traditional PDT to superficial tumours; (ii) oxygen reliance does not allow PDT treatment of hypoxic tumours; (iii) light can complicate the phototherapeutic outcomes because of the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects from undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of the current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities for ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatments.

  15. The new challenges of end-of-life tyres management systems: A Spanish case study

    Energy Technology Data Exchange (ETDEWEB)

    Uruburu, Ángel, E-mail: angel.uruburu@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Ponce-Cueto, Eva, E-mail: eva.ponce@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Center for Transportation and Logistics, Massachusetts Institute of Technology, Cambridge, MA (United States); Cobo-Benita, José Ramón, E-mail: joseramon.cobo@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Ordieres-Meré, Joaquín, E-mail: j.ordieres@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain)

    2013-03-15

    Highlights: ► Impact of the implementation of the Directive 2008/98/EC in Spain for end-of-life tyres. ► Characterization of the reverse supply chain for collecting, recovering, and treating end-of-life tyres. ► Identification of challenges to be coped and issues to be covered. ► Potential new applications for end-of-life tyres and development of new management related strategies. - Abstract: Directive 2008/98/EC released by the European Union represents a significant step forward in all relevant aspects of waste management. Under the already established, extended produced responsibility (EPR) principle, new policies have been enunciated to continuously achieve better overall environmental performance of key products throughout their life phases. This paper discusses how the directive is being articulated in Spain by the main integrated management system (IMS) for end-of-life (EOL) tyres since its creation in 2006. Focusing on the IMS technological, economic and legal aspects, the study provides a global perspective and evaluation of how the IMS is facing the current issues to resolve, the new challenges that have appeared and the management vision for the coming years.

  16. Homebirth as systems-challenging praxis: knowledge, power, and intimacy in the birthplace.

    Science.gov (United States)

    Cheyney, Melissa J

    2008-02-01

    In this article, I examine the processes and motivations involved when women in the United States choose to circumvent the dominant obstetric care paradigm by delivering at home with a group of care providers called direct-entry midwives. Using grounded theory, participant observation, and open-ended, semistructured interviewing, I collected and analyzed homebirth narratives from a theoretical sample of women (n = 50) in two research locales. Findings interpreted from the perspective of critical medical anthropology suggest that women who choose to birth at home negotiate fears associated with the "just in case something bad happens" argument that forms the foundation for hospital birth rationales through complex individual and social processes. These involve challenging established forms of authoritative knowledge, valuing alternative and more embodied or intuitive ways of knowing, and knowledge sharing through the informed consent process. Adherence to subjugated discourses combined with lived experiences of personal power and the cultivation of intimacy in the birthplace fuel homebirth not only as a minority social movement, but also as a form of systems-challenging praxis.

  17. The new challenges of end-of-life tyres management systems: A Spanish case study

    International Nuclear Information System (INIS)

    Uruburu, Ángel; Ponce-Cueto, Eva; Cobo-Benita, José Ramón; Ordieres-Meré, Joaquín

    2013-01-01

    Highlights: ► Impact of the implementation of the Directive 2008/98/EC in Spain for end-of-life tyres. ► Characterization of the reverse supply chain for collecting, recovering, and treating end-of-life tyres. ► Identification of challenges to be coped and issues to be covered. ► Potential new applications for end-of-life tyres and development of new management related strategies. - Abstract: Directive 2008/98/EC released by the European Union represents a significant step forward in all relevant aspects of waste management. Under the already established, extended produced responsibility (EPR) principle, new policies have been enunciated to continuously achieve better overall environmental performance of key products throughout their life phases. This paper discusses how the directive is being articulated in Spain by the main integrated management system (IMS) for end-of-life (EOL) tyres since its creation in 2006. Focusing on the IMS technological, economic and legal aspects, the study provides a global perspective and evaluation of how the IMS is facing the current issues to resolve, the new challenges that have appeared and the management vision for the coming years

  18. Coupled Data Assimilation for Integrated Earth System Analysis and Prediction: Goals, Challenges, and Recommendations

    Science.gov (United States)

    Penny, Stephen G.; Akella, Santha; Buehner, Mark; Chevallier, Matthieu; Counillon, Francois; Draper, Clara; Frolov, Sergey; Fujii, Yosuke; Karspeck, Alicia; Kumar, Arun

    2017-01-01

    The purpose of this report is to identify fundamental issues for coupled data assimilation (CDA), such as gaps in science and limitations in forecasting systems, in order to provide guidance to the World Meteorological Organization (WMO) on how to facilitate more rapid progress internationally. Coupled Earth system modeling provides the opportunity to extend skillful atmospheric forecasts beyond the traditional two-week barrier by extracting skill from low-frequency state components such as the land, ocean, and sea ice. More generally, coupled models are needed to support seamless prediction systems that span timescales from weather, subseasonal to seasonal (S2S), multiyear, and decadal. Therefore, initialization methods are needed for coupled Earth system models, either applied to each individual component (called Weakly Coupled Data Assimilation - WCDA) or applied the coupled Earth system model as a whole (called Strongly Coupled Data Assimilation - SCDA). Using CDA, in which model forecasts and potentially the state estimation are performed jointly, each model domain benefits from observations in other domains either directly using error covariance information known at the time of the analysis (SCDA), or indirectly through flux interactions at the model boundaries (WCDA). Because the non-atmospheric domains are generally under-observed compared to the atmosphere, CDA provides a significant advantage over single-domain analyses. Next, we provide a synopsis of goals, challenges, and recommendations to advance CDA: Goals: (a) Extend predictive skill beyond the current capability of NWP (e.g. as demonstrated by improving forecast skill scores), (b) produce physically consistent initial conditions for coupled numerical prediction systems and reanalyses (including consistent fluxes at the domain interfaces), (c) make best use of existing observations by allowing observations from each domain to influence and improve the full earth system analysis, (d) develop a robust

  19. Practicalities and challenges in re-orienting the health system in Zambia for treating chronic conditions.

    Science.gov (United States)

    Aantjes, Carolien J; Quinlan, Tim K C; Bunders, Joske F G

    2014-07-08

    The rapid evolution in disease burdens in low- and middle income countries is forcing policy makers to re-orient their health system towards a system which has the capability to simultaneously address infectious and non-communicable diseases. This paper draws on two different but overlapping studies which examined how actors in the Zambian health system are re-directing their policies, strategies and service structures to include the provision of health care for people with chronic conditions. Study methods in both studies included semi-structured interviews with government health officials at national level, and governmental and non-governmental health practitioners operating from community-, primary health care to hospital facility level. Focus group discussions were conducted with staff, stakeholders and caregivers of programmes providing care and support at community- and household levels. Study settings included urban and rural sites. A series of adaptations transformed the HIV programme from an emergency response into the first large chronic care programme in the country. There are clear indications that the Zambian government is intending to expand this reach to patients with non-communicable diseases. Challenges to do this effectively include a lack of proper NCD prevalence data for planning, a concentration of technology and skills to detect and treat NCDs at secondary and tertiary levels in the health system and limited interest by donor agencies to support this transition. The reorientation of Zambia's health system is in full swing and uses the foundation of a decentralised health system and presence of local models for HIV chronic care which actively involve community partners, patients and their families. There are early warning signs which could cause this transition to stall, one of which is the financial capability to resource this process.

  20. The challenges of connecting generation to distribution systems: a utility perspective

    International Nuclear Information System (INIS)

    Kropp, F.

    2004-01-01

    'Full text:' This presentation discusses the technical, financial and regulatory barriers to connecting generation to Distribution Systems in Ontario. Case studies will be used to provide examples of the operational and technical challenges that impact the utility as well as a discussion on the site-specific advantages and disadvantages (to the utility) of the generation connections. These studies will include discussions on the problems and lessons learned with respect to the overall project implementation and the contractual agreements. The case studies will be complemented by an explanation of the financial constraints (both short term and long term) associated with the connections, and the regulatory issues that impact the financial recovery models including net and gross load billing. (author)

  1. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Science.gov (United States)

    Sabath, F.

    2004-05-01

    The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  2. Environmental challenges for Asian-Pacific energy systems in the 1991s

    International Nuclear Information System (INIS)

    Markham, Adam; Ramani, K.V.

    1991-01-01

    This paper provides an overview of the main issues addressed and conclusions arrived at by the Regional Conference on Environmental Challenges for Asian and Pacific Energy Systems in the 1990s', jointly organized by the Asian and Pacific Development Centre and the World Wide Fund for Nature during 14-18 January 1991 at Kuala Lumpur, Malaysia. The first part of the paper focuses on the regional and global context of the conference. This is followed by a review of the key issues that are considered relevant to the shaping of a new energy policy for the region to ensure environmental sustainability. The concluding part provides some cautionary notes and suggestions for the immediate future. (author)

  3. Do alien species matter? Impacts of invasions in Indian freshwater systems and challenges in management

    Directory of Open Access Journals (Sweden)

    Murugan Muralidharan

    2017-06-01

    Full Text Available Alongside anthropogenic activities and habitat destruction, invasions are regarded as one of the most influential components of global change. India as a growing economy and rapidly developing nation has been constantly engaged in infrastructure development which consequently has led to depletion of natural resources and declining quality of habitats aquatic systems in particular. Invasions that have established from the introductions in past during the colonial era and recently spread species are great challenges that hamper survival of aquatic resources. As of 2015, 20 plants, one mollusc and 37 fishes are known to have naturalized in Indian water bodies. Awareness on the invasive species along with detailed information on the ecosystem-wide impacts is essential for management.

  4. The new challenges of end-of-life tyres management systems: a Spanish case study.

    Science.gov (United States)

    Uruburu, Angel; Ponce-Cueto, Eva; Cobo-Benita, José Ramón; Ordieres-Meré, Joaquín

    2013-03-01

    Directive 2008/98/EC released by the European Union represents a significant step forward in all relevant aspects of waste management. Under the already established, extended produced responsibility (EPR) principle, new policies have been enunciated to continuously achieve better overall environmental performance of key products throughout their life phases. This paper discusses how the directive is being articulated in Spain by the main integrated management system (IMS) for end-of-life (EOL) tyres since its creation in 2006. Focusing on the IMS technological, economic and legal aspects, the study provides a global perspective and evaluation of how the IMS is facing the current issues to resolve, the new challenges that have appeared and the management vision for the coming years. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. External cues challenging the internal appetite control system-Overview and practical implications.

    Science.gov (United States)

    Bilman, Els; van Kleef, Ellen; van Trijp, Hans

    2017-09-02

    Inadequate regulation of food intake plays an important role in the development of overweight and obesity, and is under the influence of both the internal appetite control system and external environmental cues. Especially in environments where food is overly available, external cues seem to override and/or undermine internal signals, which put severe challenges on the accurate regulation of food intake. By structuring these external cues around five different phases in the food consumption process this paper aims to provide an overview of the wide range of external cues that potentially facilitate or hamper internal signals and with that influence food intake. For each of the five phases of the food consumption process, meal initiation, meal planning, consumption phase, end of eating episode and time till next meal, the most relevant internal signals are discussed and it is explained how specific external cues exert their influence.

  6. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Directory of Open Access Journals (Sweden)

    F. Sabath

    2004-01-01

    Full Text Available The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  7. [Separation of functions in the System of Social Protection in Health, Mexico 2009: progress and challenges].

    Science.gov (United States)

    González-Robledo, Luz María; Nigenda, Gustavo; González-Robledo, María Cecilia; Reich, Michael

    2011-01-01

    To evaluate advancements and challenges in the separation of functions within Mexico's System of Social Protection in Health. A 2009 evaluation study involving nine states and the National Commission for Social Protection in Health was carried out via semi-structured interviews with key actors and literature analysis. The main advancement has been the creation of the State Regimens for Social Protection in Health (REPSS in Spanish) which act as intermediaries between users and health service providers, making these state-level entities responsible for both managing financial resources and shaping and coordinating the health care delivery network. However, most of the REPSS studied were found to be in a state of inertia, leading to inadequate compliance with legally mandated functions. Normative, technical, political and managerial obstacles persist, impeding the successful separation of functions.

  8. Technology Transfer Challenges: A Case Study of User-Centered Design in NASA's Systems Engineering Culture

    Science.gov (United States)

    Quick, Jason

    2009-01-01

    The Upper Stage (US) section of the National Aeronautics and Space Administration's (NASA) Ares I rocket will require internal access platforms for maintenance tasks performed by humans inside the vehicle. Tasks will occur during expensive critical path operations at Kennedy Space Center (KSC) including vehicle stacking and launch preparation activities. Platforms must be translated through a small human access hatch, installed in an enclosed worksite environment, support the weight of ground operators and be removed before flight - and their design must minimize additional vehicle mass at attachment points. This paper describes the application of a user-centered conceptual design process and the unique challenges encountered within NASA's systems engineering culture focused on requirements and "heritage hardware". The NASA design team at Marshall Space Flight Center (MSFC) initiated the user-centered design process by studying heritage internal access kits and proposing new design concepts during brainstorming sessions. Simultaneously, they partnered with the Technology Transfer/Innovative Partnerships Program to research inflatable structures and dynamic scaffolding solutions that could enable ground operator access. While this creative, technology-oriented exploration was encouraged by upper management, some design stakeholders consistently opposed ideas utilizing novel, untested equipment. Subsequent collaboration with an engineering consulting firm improved the technical credibility of several options, however, there was continued resistance from team members focused on meeting system requirements with pre-certified hardware. After a six-month idea-generating phase, an intensive six-week effort produced viable design concepts that justified additional vehicle mass while optimizing the human factors of platform installation and use. Although these selected final concepts closely resemble heritage internal access platforms, challenges from the application of the

  9. Adapting a regularized canopy reflectance model (REGFLEC) for the retrieval challenges of dryland agricultural systems

    KAUST Repository

    Houborg, Rasmus

    2016-08-20

    A regularized canopy reflectance model (REGFLEC) is applied over a dryland irrigated agricultural system in Saudi Arabia for the purpose of retrieving leaf area index (LAI) and leaf chlorophyll content (Chll). To improve the robustness of the retrieved properties, REGFLEC was modified to 1) correct for aerosol and adjacency effects, 2) consider foliar dust effects on modeled canopy reflectances, 3) include spectral information in the red-edge wavelength region, and 4) exploit empirical LAI estimates in the model inversion. Using multi-spectral RapidEye imagery allowed Chll to be retrieved with a Mean Absolute Deviation (MAD) of 7.9 μg cm− 2 (16%), based upon in-situ measurements conducted in fields of alfalfa, Rhodes grass and maize over the course of a growing season. LAI and Chll compensation effects on canopy reflectance were largely avoided by informing the inversion process with ancillary LAI inputs established empirically on the basis of a statistical machine learning technique. As a result, LAI was reproduced with good accuracy, with an overall MAD of 0.42 m2 m− 2 (12.5%). Results highlighted the considerable challenges associated with the translation of at-sensor radiance observations to surface bidirectional reflectances in dryland environments, where issues such as high aerosol loadings and large spatial gradients in surface reflectance from bright desert soils to dark vegetated fields are often present. Indeed, surface reflectances in the visible bands were reduced by up to 60% after correction for such adjacency effects. In addition, dust deposition on leaves required explicit modification of the reflectance sub-model to account for its influence. By implementing these model refinements, REGFLEC demonstrated its utility for within-field characterization of vegetation conditions over the challenging landscapes typical of dryland agricultural regions, offering a means through which improvements can be made in the management of these globally

  10. Multi-host expression system for recombinant production of challenging proteins.

    Science.gov (United States)

    Meyer, Steffen; Lorenz, Carmen; Baser, Bahar; Wördehoff, Mona; Jäger, Volker; van den Heuvel, Joop

    2013-01-01

    Recombinant production of complex eukaryotic proteins for structural analyses typically requires a profound screening process to identify suitable constructs for the expression of ample amounts of properly folded protein. Furthermore, the evaluation of an optimal expression host has a major impact on protein yield and quality as well as on actual cost of the production process. Here we present a novel fast expression system for multiple hosts based on a single donor vector termed pFlp-Bac-to-Mam. The range of applications of pFlp-Bac-to-Mam comprises highly efficient transient transfection of HEK293-6E in serum-free suspension culture and subsequent large-scale production of challenging proteins expressing in mg per Liter level using either the baculoviral expression vector system or stable CHO production cell lines generated by Flp-mediated cassette exchange. The success of the multi-host expression vector to identify the optimal expression strategy for efficient production of high quality protein is demonstrated in a comparative expression study of three model proteins representing different protein classes: intracellular expression using a fluorescent protein, secretion of a single-chain-Fv-hIgG1Fc fusion construct and production of a large amount of highly homogeneous protein sample of the extracellular domain of a Toll-like receptor. The evaluation of the production efficiency shows that the pFlp-Bac-to-Mam system allows a fast and individual optimization of the expression strategy for each protein class.

  11. Reawakening the Irish language through the ırish education system: Challenges and priorities

    Directory of Open Access Journals (Sweden)

    T.J. Ó Ceallaigh

    2015-12-01

    Full Text Available As a language, Irish is unique to Ireland and is, therefore, of crucial importance to the identity of the Irish people, to Irish culture and to world heritage. The Irish language however has had a turbulent and traumatic history and has endured a complex and varied relationship with the Irish people. Since the foundation of the Irish Free State, the education system has been targeted as an agency and model for Irish language planning, education and language revitalisation and has had a critical role in generating linguistic ability in the Irish language. This paper reviews the complex and controversial relationship between the Irish language, the State and the education system from an historical perspective. Some key acts of recent legislation and government initiatives, which impact on the status of the Irish language are considered and barriers and challenges to progress in the education system are outlined. The paper concludes with a discussion on significant positive factors which may revolutionise and reawaken the Irish language through our education syste

  12. Challenges and models in supporting logistics system design for dedicated-biomass-based bioenergy industry.

    Science.gov (United States)

    Zhu, Xiaoyan; Li, Xueping; Yao, Qingzhu; Chen, Yuerong

    2011-01-01

    This paper analyzed the uniqueness and challenges in designing the logistics system for dedicated biomass-to-bioenergy industry, which differs from the other industries, due to the unique features of dedicated biomass (e.g., switchgrass) including its low bulk density, restrictions on harvesting season and frequency, content variation with time and circumambient conditions, weather effects, scattered distribution over a wide geographical area, and so on. To design it, this paper proposed a mixed integer linear programming model. It covered from planting and harvesting switchgrass to delivering to a biorefinery and included the residue handling, concentrating on integrating strategic decisions on the supply chain design and tactical decisions on the annual operation schedules. The present numerical examples verified the model and demonstrated its use in practice. This paper showed that the operations of the logistics system were significantly different for harvesting and non-harvesting seasons, and that under the well-designed biomass logistics system, the mass production with a steady and sufficient supply of biomass can increase the unit profit of bioenergy. The analytical model and practical methodology proposed in this paper will help realize the commercial production in biomass-to-bioenergy industry. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges.

    Science.gov (United States)

    Montanez-Sauri, Sara I; Beebe, David J; Sung, Kyung Eun

    2015-01-01

    The increasing interest in studying cells using more in vivo-like three-dimensional (3D) microenvironments has created a need for advanced 3D screening platforms with enhanced functionalities and increased throughput. 3D screening platforms that better mimic in vivo microenvironments with enhanced throughput would provide more in-depth understanding of the complexity and heterogeneity of microenvironments. The platforms would also better predict the toxicity and efficacy of potential drugs in physiologically relevant conditions. Traditional 3D culture models (e.g., spinner flasks, gyratory rotation devices, non-adhesive surfaces, polymers) were developed to create 3D multicellular structures. However, these traditional systems require large volumes of reagents and cells, and are not compatible with high-throughput screening (HTS) systems. Microscale technology offers the miniaturization of 3D cultures and allows efficient screening of various conditions. This review will discuss the development, most influential works, and current advantages and challenges of microscale culture systems for screening cells in 3D microenvironments.

  14. Challenges in Wireless System Integration as Enablers for Indoor Context Aware Environments

    Directory of Open Access Journals (Sweden)

    Peio López-Iturri

    2017-07-01

    Full Text Available The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes. In this context, inherent transceiver density poses challenges in overall system operation, given by multiple node operation which increases overall interference levels. In this work, a deterministic based analysis applied to variable density wireless sensor network operation within complex indoor scenarios is presented, as a function of topological node distribution. The extensive analysis derives interference characterizations, both for conventional transceivers as well as wearables, which provide relevant information in terms of individual node configuration as well as complete network layout.

  15. Challenges in reducing the computational time of QSTS simulations for distribution system analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Deboever, Jeremiah [Georgia Inst. of Technology, Atlanta, GA (United States); Zhang, Xiaochen [Georgia Inst. of Technology, Atlanta, GA (United States); Reno, Matthew J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grijalva, Santiago [Georgia Inst. of Technology, Atlanta, GA (United States); Therrien, Francis [CME International T& D, St. Bruno, QC (Canada)

    2017-06-01

    The rapid increase in penetration of distributed energy resources on the electric power distribution system has created a need for more comprehensive interconnection modelling and impact analysis. Unlike conventional scenario - based studies , quasi - static time - series (QSTS) simulation s can realistically model time - dependent voltage controllers and the diversity of potential impacts that can occur at different times of year . However, to accurately model a distribution system with all its controllable devices, a yearlong simulation at 1 - second resolution is often required , which could take conventional computers a computational time of 10 to 120 hours when an actual unbalanced distribution feeder is modeled . This computational burden is a clear l imitation to the adoption of QSTS simulation s in interconnection studies and for determining optimal control solutions for utility operations . Our ongoing research to improve the speed of QSTS simulation has revealed many unique aspects of distribution system modelling and sequential power flow analysis that make fast QSTS a very difficult problem to solve. In this report , the most relevant challenges in reducing the computational time of QSTS simulations are presented: number of power flows to solve, circuit complexity, time dependence between time steps, multiple valid power flow solutions, controllable element interactions, and extensive accurate simulation analysis.

  16. Planning of Polish physician workforce - Systemic inconsistencies, challenges and possible ways forward.

    Science.gov (United States)

    Domagała, Alicja; Klich, Jacek

    2018-02-01

    Poland has the lowest number of physicians per 1000 population (2.2/1000) in the EU. This is accompanied by a considerable migration rate of Polish physicians to other EU countries (estimated at above 7%). Among other consequences, this results in waiting lists and unmet health needs. The aim of this article is an identification of the main challenges for physician workforce planning in Poland. The authors analysed national and international documents, reports, official statements, publications and statistical databases. In Poland health workforce planning is inadequate and insufficient. There is no formal structure and no strategy regarding human resource planning or regular forecasts for the health workforce, which results in many negative effects for the healthcare system. Currently the shortage of physicians in some specialties is becoming one of the most important reasons for limited access to care and lengthening the average wait time. To improve this situation operational and strategic actions should be undertaken without unnecessary delay. Effective and close cooperation between key stakeholders is needed. Health workforce planning needs to become one of the key building blocks of the Polish health system's reforms, strongly connected to the other functions of the health system. It is essential for Poland to follow available good practices in health workforce planning. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Continuing Education Meets the Learning Organization: The Challenge of a Systems Approach to Patient Safety.

    Science.gov (United States)

    Eisenberg, John M

    2017-01-01

    Since the release of the report of the Institute of Medicine on medical errors and patient safety in November 1999, health policy makers and health care leaders in several nations have sought solutions that will improve the safety of health care. This attention to patient safety has highlighted the importance of a learning approach and a systems approach to quality measurement and improvement. Balanced with the need for public disclosure of performance, confidential reporting with feedback is one of the prime ways that nations such as the United States, Canada, the United Kingdom, and Australia have approached this challenge. In the United States, the Quality Interagency Coordination Task Force has convened federal agencies that are involved in health care quality improvement for a coordinated initiative. Based on an investment in a strong research foundation in health care quality measurement and improvement, there are eight key lessons for continuing education if it is to parlay the interest in patient safety into enhanced continuing education and quality improvement in learning health care systems. The themes for these lessons are (1) informatics for information, (2) guidelines as learning tools, (3) learning from opinion leaders, (4) learning from the patient, (5) decision support systems, (6) the team learning together, (7) learning organizations, and (8) just-in-time and point-of care delivery.

  18. Challenges in Albania for improving Labor Market Information System and Labor Market Governance

    Directory of Open Access Journals (Sweden)

    Neshat Zeneli

    2017-07-01

    Full Text Available Labour Market Policy of the Republic of Albania in terms of design (preparation, case identification, formulation, and approval, programming and budgeting, implementation, monitoring and evaluation has a short experience (1995-ongoing. The influence and presence of hierarchy model is very high beside the support of different programs and projects through bilateral and EU programs. Still there are a lot of key issues to be addressed. The most important issues to be addressed in this paper are evidence based related to: • The Availability of Labor Market Information and its structure on national, regional and local level in Albania and how much this information is used for -policy making and –monitoring/evaluation in terms of input, output, outcome and impact. • Mode of the governance of the labor market in Albania and challenges to pass from the hierarchy to market and network governance. The main aim of this paper/article is to do a complete and deep analysis of the actual situation of labor market information system and labor market governance in Albania, and to propose conclusions and recommendations that will improve both labor market information system and the labor market governance from hierarchy to market and network governance, because good and standardized labor information system can help towards right policy decisions and good governance of LM policy means more employment, more stability, more social inclusion in the society.

  19. Challenges in Scheduling Aggregation in CyberPhysical Information Processing Systems

    Energy Technology Data Exchange (ETDEWEB)

    Horey, James L [ORNL; Lagesse, Brent J [ORNL

    2011-01-01

    Data aggregation (a.k.a reduce operations) is an important element in information processing systems, including MapReduce clusters and cyberphysical networks. Unlike simple sensor networks, all the data in information processing systems must be eventually aggregated. Our goal is to lower overall latency in these systems by intelligently scheduling aggregation on intermediate routing nodes. Unlike previous models, our model explicitly takes into account link latency and computa- tion time. Our model also considers heterogeneous computing capabilities. In order to understand the potential challenges associated with constructing a distributed scheduler that minimizes la- tency, we ve developed a simulation of our model and tested the results of randomly scheduling nodes. Although these experiments were designed to provide data for a null-model, preliminary results have yielded a few interesting observations. We show that in cases where the computation time is larger than transmission time, in-network aggregation can have a large effect (reducing latency by 50% or more), but that naive scheduling can have a detrimental effect. Specifically, we show that when the root node (a.k.a the basestation) is faster than the other nodes, the latency can increase with increased coverage, and that these effects vary with the number of nodes present.

  20. The Challenges Facing the Multilateral Trading System in Addressing Global Public Policy Objectives

    Directory of Open Access Journals (Sweden)

    Christophe Bellmann

    2013-02-01

    Full Text Available Despite a record-breaking 14.5 per cent increase in world merchandise exports, the effects of the financial crisis and global recession are still hampering faster economic recovery. Relatively high oil prices combined with persistent unemployment and measures designed to reduce budget deficits have undermined short-term growth prospects. While South–South trade continues to explode, trade imbalances – i.e. the gap between exports and imports – widened in 2010 compared to 2009 (though smaller than pre-crisis levels. Meanwhile, trade negotiations under the Doha Round have reached an impasse, generating uncertainties about the future of the World Trade Organization (WTO as a negotiating forum. Under these circumstances, should the system rethink its decision-making process founded upon the predominance of member states, the principle of consensus and the notion of single undertaking, as some critics have suggested? And, if so, how could such a reform agenda be initiated at the WTO? Moreover, beyond the negotiating function of the WTO, the paralysis of the system also raises urgent questions about the ability of the system to respond to pressing challenges of our times, such as trade and climate change, or food security and price volatility.

  1. Defining the methodological challenges and opportunities for an effective science of sociotechnical systems and safety

    Science.gov (United States)

    Waterson, Patrick; Robertson, Michelle M.; Cooke, Nancy J.; Militello, Laura; Roth, Emilie; Stanton, Neville A.

    2015-01-01

    An important part of the application of sociotechnical systems theory (STS) is the development of methods, tools and techniques to assess human factors and ergonomics workplace requirements. We focus in this paper on describing and evaluating current STS methods for workplace safety, as well as outlining a set of six case studies covering the application of these methods to a range of safety contexts. We also describe an evaluation of the methods in terms of ratings of their ability to address a set of theoretical and practical questions (e.g. the degree to which methods capture static/dynamic aspects of tasks and interactions between system levels). The outcomes from the evaluation highlight a set of gaps relating to the coverage and applicability of current methods for STS and safety (e.g. coverage of external influences on system functioning; method usability). The final sections of the paper describe a set of future challenges, as well as some practical suggestions for tackling these. Practitioner Summary: We provide an up-to-date review of STS methods, a set of case studies illustrating their use and an evaluation of their strengths and weaknesses. The paper concludes with a ‘roadmap’ for future work. PMID:25832121

  2. Nitrogen cycling in Bioregenerative Life Support Systems: Challenges for waste refinery and food production processes

    Science.gov (United States)

    Clauwaert, Peter; Muys, Maarten; Alloul, Abbas; De Paepe, Jolien; Luther, Amanda; Sun, Xiaoyan; Ilgrande, Chiara; Christiaens, Marlies E. R.; Hu, Xiaona; Zhang, Dongdong; Lindeboom, Ralph E. F.; Sas, Benedikt; Rabaey, Korneel; Boon, Nico; Ronsse, Frederik; Geelen, Danny; Vlaeminck, Siegfried E.

    2017-05-01

    In order to sustain human life in an isolated environment, an efficient conversion of wasted nutrients to food might become mandatory. This is particularly the case for space missions where resupply from earth or in-situ resource utilization is not possible or desirable. A combination of different technologies is needed to allow full recycling of e.g. nitrogenous compounds in space. In this review, an overview is given of the different essential processes and technologies that enable closure of the nitrogen cycle in Bioregenerative Life Support Systems (BLSS). Firstly, a set of biological and physicochemical refinery stages ensures efficient conversion of waste products into the building blocks, followed by the production of food with a range of biological methods. For each technology, bottlenecks are identified. Furthermore, challenges and outlooks are presented at the integrated system level. Space adaptation and integration deserve key attention to enable the recovery of nitrogen for the production of nutritional food in space, but also in closed loop systems on earth.

  3. Challenges in small screening laboratories: implementing an on-demand laboratory information management system.

    Science.gov (United States)

    Lemmon, Vance P; Jia, Yuanyuan; Shi, Yan; Holbrook, S Douglas; Bixby, John L; Buchser, William

    2011-11-01

    The Miami Project to Cure Paralysis, part of the University of Miami Miller School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) of neurons. The goal of the laboratory is to uncover signaling pathways, genes, compounds, or drugs that can be used to promote nerve growth. HCA permits the quantification of neuronal morphology, including the lengths and numbers of axons. HCA of various libraries on primary neurons requires a team-based approach, a variety of process steps and complex manipulations of cells and libraries to obtain meaningful results. HCA itself produces vast amounts of information including images, well-based data and cell-based phenotypic measures. Documenting and integrating the experimental workflows, library data and extensive experimental results is challenging. For academic laboratories generating large data sets from experiments involving thousands of perturbagens, a Laboratory Information Management System (LIMS) is the data tracking solution of choice. With both productivity and efficiency as driving rationales, the Miami Project has equipped its HCA laboratory with an On Demand or Software As A Service (SaaS) LIMS to ensure the quality of its experiments and workflows. The article discusses how the system was selected and integrated into the laboratory. The advantages of a SaaS based LIMS over a client-server based system are described. © 2011 Bentham Science Publishers

  4. Wind Energy Deployment in Isolated Islanded Power Systems: Challenges & Realities (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Baring-Gould, I.

    2014-05-01

    Rising costs of fuels, energy surety, and the carbon impacts of diesel fuel are driving remote and islanded communities dependent on diesel power generation to look for alternatives. Over the past few years, interest in using wind energy to reduce diesel fuel consumption has increased dramatically, potentially providing economic, environmental, social, and security benefits to the energy supply of isolated and islanded communities. However, the task of implementing such systems has remained elusive and subject to many cases of lower-than-expected performance. This poster describes the current status of integrating higher contribution wind technology into islanded power systems, the progress of recent initiatives implemented by the U.S. Department of Energy and Interior, and some of the lingering technical and commercial challenges. Operating experience from a number of power systems is described. The worldwide market for wind development in islanded communities (some of these supplying large domestic loads) provides a strong market niche for the wind industry, even in the midst of a slow global recovery.

  5. Challenges in Wireless System Integration as Enablers for Indoor Context Aware Environments.

    Science.gov (United States)

    López-Iturri, Peio; Aguirre, Erik; Azpilicueta, Leyre; Astrain, José Javier; Villandangos, Jesús; Falcone, Francisco

    2017-07-12

    The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes. In this context, inherent transceiver density poses challenges in overall system operation, given by multiple node operation which increases overall interference levels. In this work, a deterministic based analysis applied to variable density wireless sensor network operation within complex indoor scenarios is presented, as a function of topological node distribution. The extensive analysis derives interference characterizations, both for conventional transceivers as well as wearables, which provide relevant information in terms of individual node configuration as well as complete network layout.

  6. Open source challenges for hospital information system (HIS) in developing countries: a pilot project in Mali.

    Science.gov (United States)

    Bagayoko, Cheick-Oumar; Dufour, Jean-Charles; Chaacho, Saad; Bouhaddou, Omar; Fieschi, Marius

    2010-04-16

    We are currently witnessing a significant increase in use of Open Source tools in the field of health. Our study aims to research the potential of these software packages for developing countries. Our experiment was conducted at the Centre Hospitalier Mere Enfant in Mali. After reviewing several Open Source tools in the field of hospital information systems, Mediboard software was chosen for our study. To ensure the completeness of Mediboard in relation to the functionality required for a hospital information system, its features were compared to those of a well-defined comprehensive record management tool set up at the University Hospital "La Timone" of Marseilles in France. It was then installed on two Linux servers: a first server for testing and validation of different modules, and a second one for the deployed full implementation. After several months of use, we have evaluated the usability aspects of the system including feedback from end-users through a questionnaire. Initial results showed the potential of Open Source in the field of health IT for developing countries like Mali.Five main modules have been fully implemented: patient administrative and medical records management of hospital activities, tracking of practitioners' activities, infrastructure management and the billing system. This last component of the system has been fully developed by the local Mali team.The evaluation showed that the system is broadly accepted by all the users who participated in the study. 77% of the participants found the system useful; 85% found it easy; 100% of them believe the system increases the reliability of data. The same proportion encourages the continuation of the experiment and its expansion throughout the hospital. In light of the results, we can conclude that the objective of our study was reached. However, it is important to take into account the recommendations and the challenges discussed here to avoid several potential pitfalls specific to the context of

  7. Open source challenges for hospital information system (HIS in developing countries: a pilot project in Mali

    Directory of Open Access Journals (Sweden)

    Chaacho Saad

    2010-04-01

    Full Text Available Abstract Background We are currently witnessing a significant increase in use of Open Source tools in the field of health. Our study aims to research the potential of these software packages for developing countries. Our experiment was conducted at the Centre Hospitalier Mere Enfant in Mali. Methods After reviewing several Open Source tools in the field of hospital information systems, Mediboard software was chosen for our study. To ensure the completeness of Mediboard in relation to the functionality required for a hospital information system, its features were compared to those of a well-defined comprehensive record management tool set up at the University Hospital "La Timone" of Marseilles in France. It was then installed on two Linux servers: a first server for testing and validation of different modules, and a second one for the deployed full implementation. After several months of use, we have evaluated the usability aspects of the system including feedback from end-users through a questionnaire. Results Initial results showed the potential of Open Source in the field of health IT for developing countries like Mali. Five main modules have been fully implemented: patient administrative and medical records management of hospital activities, tracking of practitioners' activities, infrastructure management and the billing system. This last component of the system has been fully developed by the local Mali team. The evaluation showed that the system is broadly accepted by all the users who participated in the study. 77% of the participants found the system useful; 85% found it easy; 100% of them believe the system increases the reliability of data. The same proportion encourages the continuation of the experiment and its expansion throughout the hospital. Conclusions In light of the results, we can conclude that the objective of our study was reached. However, it is important to take into account the recommendations and the challenges discussed

  8. Cultured meat from stem cells: challenges and prospects.

    Science.gov (United States)

    Post, Mark J

    2012-11-01

    As one of the alternatives for livestock meat production, in vitro culturing of meat is currently studied. The generation of bio-artificial muscles from satellite cells has been ongoing for about 15 years, but has never been used for generation of meat, while it already is a great source of animal protein. In order to serve as a credible alternative to livestock meat, lab or factory grown meat should be efficiently produced and should mimic meat in all of its physical sensations, such as visual appearance, smell, texture and of course, taste. This is a formidable challenge even though all the technologies to create skeletal muscle and fat tissue have been developed and tested. The efficient culture of meat will primarily depend on culture conditions such as the source of medium and its composition. Protein synthesis by cultured skeletal muscle cells should further be maximized by finding the optimal combination of biochemical and physical conditions for the cells. Many of these variables are known, but their interactions are numerous and need to be mapped. This involves a systematic, if not systems, approach. Given the urgency of the problems that the meat industry is facing, this endeavor is worth undertaking. As an additional benefit, culturing meat may provide opportunities for production of novel and healthier products. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Universal coverage challenges require health system approaches; the case of India.

    Science.gov (United States)

    Duran, Antonio; Kutzin, Joseph; Menabde, Nata

    2014-02-01

    This paper uses the case of India to demonstrate that Universal Health Coverage (UHC) is about not only health financing; personal and population services production issues, stewardship of the health system and generation of the necessary resources and inputs need to accompany the health financing proposals. In order to help policy makers address UHC in India and sort out implementation issues, the framework developed by the World Health Organization (WHO) in the World Health Report 2000 and its subsequent extensions are advocated. The framework includes final goals, generic intermediate objectives and four inter-dependent functions which interact as a system; it can be useful by diagnosing current shortcomings and facilitating the filling up of gaps between functions and goals. Different positions are being defended in India re the preconditions for UHC to succeed. This paper argues that more (public) money will be important, but not enough; it needs to be supplemented with broad interventions at various health system levels. The paper analyzes some of the most important issues in relation to the functions of service production, generation of inputs and the necessary stewardship. It also pays attention to reform implementation, as different from its design, and suggests critical aspects emanating from a review of recent health system reforms. Precisely because of the lack of comparative reference for India, emphasis is made on the need to accompany implementation with analysis, so that the "solutions" ("what to do?", "how to do it?") are found through policy analysis and research embedded into flexible implementation. Strengthening "evidence-to-policy" links and the intelligence dimension of stewardship/leadership as well as accountability during implementation are considered paramount. Countries facing similar challenges to those faced by India can also benefit from the above approaches. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  10. Design challenges in nanoparticle-based platforms: Implications for targeted drug delivery systems

    Science.gov (United States)

    Mullen, Douglas Gurnett

    Characterization and control of heterogeneous distributions of nanoparticle-ligand components are major design challenges for nanoparticle-based platforms. This dissertation begins with an examination of poly(amidoamine) (PAMAM) dendrimer-based targeted delivery platform. A folic acid targeted modular platform was developed to target human epithelial cancer cells. Although active targeting was observed in vitro, active targeting was not found in vivo using a mouse tumor model. A major flaw of this platform design was that it did not provide for characterization or control of the component distribution. Motivated by the problems experienced with the modular design, the actual composition of nanoparticle-ligand distributions were examined using a model dendrimer-ligand system. High Pressure Liquid Chromatography (HPLC) resolved the distribution of components in samples with mean ligand/dendrimer ratios ranging from 0.4 to 13. A peak fitting analysis enabled the quantification of the component distribution. Quantified distributions were found to be significantly more heterogeneous than commonly expected and standard analytical parameters, namely the mean ligand/nanoparticle ratio, failed to adequately represent the component heterogeneity. The distribution of components was also found to be sensitive to particle modifications that preceded the ligand conjugation. With the knowledge gained from this detailed distribution analysis, a new platform design was developed to provide a system with dramatically improved control over the number of components and with improved batch reproducibility. Using semi-preparative HPLC, individual dendrimer-ligand components were isolated. The isolated dendrimer with precise numbers of ligands were characterized by NMR and analytical HPLC. In total, nine different dendrimer-ligand components were obtained with degrees of purity ≥80%. This system has the potential to serve as a platform to which a precise number of functional molecules

  11. Costs and epidemiological changes of chronic diseases: implications and challenges for health systems.

    Directory of Open Access Journals (Sweden)

    Armando Arredondo

    Full Text Available The need to integrate economic and epidemiological aspects in the clinical perspective leads to a proposal for the analysis of health disparities and to an evaluation of the health services and of the new challenges which are now being faced by health system reforms in middle income countries.To identify the epidemiological changes, the demand for health services and economic burden from chronic diseases (diabetes and hypertension in a middle income county.We conducted longitudinal analyses of costs and epidemiological changes for diabetes and hypertension in the Mexican health system. The study population included both the insured and uninsured populations. The cost-evaluation method was used, based on the instrumentation and consensus techniques. To estimate the epidemiological changes and financial consequences for 2014-2016, six models were constructed according to the Box-Jenkins technique, using confidence intervals of 95%, and the Box-Pierce test.Regarding epidemiological changes expected in both diseases for 2014 vs. 2016, an increase is expected, although results predict a greater increase for diabetes, 8-12% in all three studied institutions, (p < .05. Indeed, in the case of diabetes, the increase was 41469 cases for uninsured population (SSA and 65737 for the insured population (IMSS and ISSSTE. On hypertension cases the increase was 38109 for uninsured vs 62895 for insured. Costs in US$ ranged from $699 to $748 for annual case management per patient in the case of diabetes, and from $485 to $622 in patients with hypertension. Comparing financial consequences of health services required by insured and uninsured populations, the greater increase (23% will be for the insured population (p < .05. The financial requirements of both diseases will amount to 19.5% of the total budget for the uninsured and 12.5% for the insured population.If the risk factors and the different health care models remain as they currently are, the economic

  12. Evolving the Nation's Energy Infrastructure: A Challenging System Issue for the Twenty-First Century; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, B.

    2007-04-01

    Over the next several decades, a profound transformation of the global energy enterprise will occur driven largely by population growth and economic development. How this growing demand for energy is met poses one of the most complex and challenging issues of our time. The current national energy dialogue reflects the challenge in simultaneously considering the social, political, economic, and technical issues as the energy system is defined, technical targets are established, and programs and investments are implemented to meet those technical targets. This paper examines the general concepts and options for meeting this challenge.

  13. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2012-12-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system.Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies.Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field.Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis.Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models.Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes. The

  14. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2013-02-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system. Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies. Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field. Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis. Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models. Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes

  15. Opportunities and challenges of Web 2.0 within the health care systems: an empirical exploration.

    Science.gov (United States)

    Lupiáñez-Villanueva, Francisco; Mayer, Miquel Angel; Torrent, Joan

    2009-09-01

    The Internet has become one of the main drivers of e-health. Whilst its impact and potential is being analysed, the Web 2.0 phenomenon has reached the health field and has emerged as a buzzword that people use to describe a wide range of online activities and applications. The aims of this article are: to explore the opportunities and challenges of the Web 2.0 within the health care system and to identify the gap between the potential of these online activities and applications and the empirical data. The analysis is based on: online surveys to physicians, nurses, pharmacist and patient support groups; static web shot analysis of 1240 web pages and exploration of the most popular Web 2.0 initiatives. The empirical results contrast with the Web 2.0 trends identified. Whereas the main characteristic of the Web 2.0 is the opportunity for social interaction, the health care system at large could currently be characterised by: a lack of interactive communication technologies available on the Internet; a lack of professional production of health care information on the Internet, and a lack of interaction between these professionals and patients on the Internet. These results reveal a scenario away from 2.0 trends.

  16. Overview of status and challenges of system testing on chip with embedded DRAMS

    Science.gov (United States)

    Falter, T.; Richter, D.

    2000-05-01

    The combination of logic together with DRAM as a system on chip (SOC) has many advantages for a large variety of computing and network applications. The goal of testing a system is to detect the fabrication caused faults in order to guarantee the defined quality. The increasing size of memories, shrinking dimensions, higher demands on application (frequency and temperature range) and quality cause new problems and higher costs of testing. On the other hand the pressure to serve the market with low cost products forces the test engineer to reduce test costs by reducing test times and using low cost test equipment. Different solutions are discussed in this paper in order to meet these challenges. The variety of test approaches for testing SOC with embedded DRAMs reaches from testing with completely chip external test logic, a simple on-chip test logic up to a full blown built-in self test (BIST) on chip. Which choice is the right one depends on different criteria e.g. memory size, quality demands and application of the product. As an example the modular embedded DRAM core concept from Infineon Technologies is discussed, which includes a dedicated modular test concept based on on-chip integration of a test controller.

  17. Health Information System Role-Based Access Control Current Security Trends and Challenges.

    Science.gov (United States)

    de Carvalho Junior, Marcelo Antonio; Bandiera-Paiva, Paulo

    2018-01-01

    This article objective is to highlight implementation characteristics, concerns, or limitations over role-based access control (RBAC) use on health information system (HIS) using industry-focused literature review of current publishing for that purpose. Based on the findings, assessment for indication of RBAC is obsolete considering HIS authorization control needs. We have selected articles related to our investigation theme "RBAC trends and limitations" in 4 different sources related to health informatics or to the engineering technical field. To do so, we have applied the following search query string: "Role-Based Access Control" OR "RBAC" AND "Health information System" OR "EHR" AND "Trends" OR "Challenges" OR "Security" OR "Authorization" OR "Attacks" OR "Permission Assignment" OR "Permission Relation" OR "Permission Mapping" OR "Constraint". We followed PRISMA applicable flow and general methodology used on software engineering for systematic review. 20 articles were selected after applying inclusion and exclusion criteria resulting contributions from 10 different countries. 17 articles advocate RBAC adaptations. The main security trends and limitations mapped were related to emergency access, grant delegation, and interdomain access control. Several publishing proposed RBAC adaptations and enhancements in order to cope current HIS use characteristics. Most of the existent RBAC studies are not related to health informatics industry though. There is no clear indication of RBAC obsolescence for HIS use.

  18. An exploration of neuromorphic systems and related design issues/challenges in dark silicon era

    Science.gov (United States)

    Chandaliya, Mudit; Chaturvedi, Nitin; Gurunarayanan, S.

    2018-03-01

    The current microprocessors has shown a remarkable performance and memory capacity improvement since its innovation. However, due to power and thermal limitations, only a fraction of cores can operate at full frequency at any instant of time irrespective of the advantages of new technology generation. This phenomenon of under-utilization of microprocessor is called as dark silicon which leads to distraction in innovative computing. To overcome the limitation of utilization wall, IBM technologies explored and invented neurosynaptic system chips. It has opened a wide scope of research in the field of innovative computing, technology, material sciences, machine learning etc. In this paper, we first reviewed the diverse stages of research that have been influential in the innovation of neurosynaptic architectures. These, architectures focuses on the development of brain-like framework which is efficient enough to execute a broad set of computations in real time while maintaining ultra-low power consumption as well as area considerations in mind. We also reveal the inadvertent challenges and the opportunities of designing neuromorphic systems as presented by the existing technologies in the dark silicon era, which constitute the utmost area of research in future.

  19. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

    Directory of Open Access Journals (Sweden)

    Shailbala Singh

    Full Text Available Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA metastatic melanoma lung tumor formation by sublingual vaccination with the model tumor antigen OVA plus synthetic glycolipid alpha-galactosylceramide (aGalCer for harnessing the adjuvant potential of natural killer T (NKT cells, which effectively bridge innate and adaptive arms of the immune system. The protective efficacy of immunization with OVA plus aGalCer was antigen-specific as immunized mice challenged with parental B16 tumors lacking OVA expression were not protected. Multiple sublingual immunizations in the presence, but not in the absence of aGalCer, resulted in repeated activation of NKT cells in the draining lymph nodes, spleens, and lungs of immunized animals concurrent with progressively increasing OVA-specific CD8+ T cell responses as well as serum IgG and vaginal IgA levels. Furthermore, sublingual administration of the antigen only in the presence of the aGalCer adjuvant effectively boosted the OVA-specific immune responses. These results support potential clinical utility of sublingual route of vaccination with aGalCer-for prevention of pulmonary metastases.

  20. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

    Science.gov (United States)

    Singh, Shailbala; Yang, Guojun; Schluns, Kimberly S; Anthony, Scott M; Sastry, K Jagannadha

    2014-01-01

    Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA) metastatic melanoma lung tumor formation by sublingual vaccination with the model tumor antigen OVA plus synthetic glycolipid alpha-galactosylceramide (aGalCer) for harnessing the adjuvant potential of natural killer T (NKT) cells, which effectively bridge innate and adaptive arms of the immune system. The protective efficacy of immunization with OVA plus aGalCer was antigen-specific as immunized mice challenged with parental B16 tumors lacking OVA expression were not protected. Multiple sublingual immunizations in the presence, but not in the absence of aGalCer, resulted in repeated activation of NKT cells in the draining lymph nodes, spleens, and lungs of immunized animals concurrent with progressively increasing OVA-specific CD8+ T cell responses as well as serum IgG and vaginal IgA levels. Furthermore, sublingual administration of the antigen only in the presence of the aGalCer adjuvant effectively boosted the OVA-specific immune responses. These results support potential clinical utility of sublingual route of vaccination with aGalCer-for prevention of pulmonary metastases.

  1. A Concise Presentation of Doubly Fed Induction Generator Wind Energy Conversion Systems Challenges and Solutions

    Directory of Open Access Journals (Sweden)

    Julius Mwaniki

    2017-01-01

    Full Text Available There is increased worldwide wind power generation, a large percentage of which is grid connected. The doubly fed induction generator (DFIG wind energy conversion system (WECS has many merits and, as a result, large numbers have been installed to date. The DFIG WECS operation, under both steady state and fault conditions, is of great interest since it impacts on grid performance. This review paper presents a condensed look at the various applied solutions to the challenges of the DFIG WECS including maximum power point tracking, common mode voltages, subsynchronous resonance, losses, modulation, power quality, and faults both internal and from the grid. It also looks at approaches used to meet the increasingly stringent grid codes requirements for the DFIG WECS to not only ride through faults but also provide voltage support. These are aspects of the DFIG WECS that are critical for system operators and prospective investors and can also serve as an introduction for new entrants into this area of study.

  2. Integration of gross anatomy in an organ system-based medical curriculum: strategies and challenges.

    Science.gov (United States)

    Brooks, William S; Woodley, Kristina T C Panizzi; Jackson, James R; Hoesley, Craig J

    2015-01-01

    The University of Alabama School of Medicine (UASOM) instituted a fully integrated, organ system-based preclinical curriculum in 2007. Gross anatomy and embryology were integrated with other basic science disciplines throughout the first two years of undergraduate medical education. Here we describe the methods of instruction and integration of gross anatomy and embryology in this curriculum as well as challenges faced along the way. Gross anatomy and embryology are taught through a combination of didactic lectures, team-based learning activities, and cadaveric dissection laboratories. Vertical integration occurs through third- and fourth-year anatomy and embryology elective courses. Radiology is integrated with anatomy instruction through self-study modules and hands-on ultrasound sessions. Our model of anatomy instruction is time efficient, clinically relevant, and effective as demonstrated by student performance on the United States Medical Licensing Examination(®) (USMLE(®) ) Step 1 examination. We recommend that medical schools considering full integration of gross anatomy and embryology (1) carefully consider the sequencing of organ system modules, (2) be willing to sacrifice anatomical detail for clinical application, (3) provide additional electives to third- and fourth-year students, and (4) integrate radiology with anatomical education. © 2014 American Association of Anatomists.

  3. Challenges of Executive Information Systems in listed Johannesburg Stock Exchange companies

    Directory of Open Access Journals (Sweden)

    Elmarie Papageorgiou

    2011-09-01

    Objectives: The purpose of this study is to establish and to determine the existence, and to what extent EISs exist in all levels of management and to identify the challenges companies experienced in listed JSE companies. Therefore the problem exists that EIS-users at all levels of management are unaware of the challenges of EISs and that EISs can be used as a tool to analyse their businesses’ performance and competitiveness. Method: A mixed method was used; both quantitative and qualitative in nature. Questionnaires were sent to 334 listed JSE companies and 13 interviews were conducted with users of EISs in all levels of management. Results: The results of the study demonstrate that the majority of respondents of the questionnaire have an EIS or plan to implement an EIS. The results further revealed the respondents’ positive attitude towards EISs as it is an excellent management information tool that adds strategic value to their business, that is critical for real-time decision-making, solves problems and creates a competitive edge. From the results it is evident that there is a need for an EIS to be ‘everybody’s information system’. The results of the interviews demonstrate that an EIS is a seamless reliable system necessary for proper timeous decision-making. The respondents to the questionnaire and the interviewees indicated that they understood the value of EISs as a useful part of their company. Conclusion: The study adds value to the awareness and understanding of EISs that creates a business environment in which business and management can enhance sustainability and strategic competitiveness.

  4. Intelligent systems for urban search and rescue: challenges and lessons learned

    Science.gov (United States)

    Jacoff, Adam; Messina, Elena; Weiss, Brian A.

    2003-09-01

    Urban search and rescue (USAR) is one of the most dangerous and time-critical non-wartime activities. Researchers have been developing hardware and software to enable robots to perform some search and rescue functions so as to minimize the exposure of human rescue personnel to danger and maximize the survival of victims. Significant progress has been achieved, but much work remains. USAR demands a blending of numerous specialized technologies. An effective USAR robot must be endowed with key competencies, such as being able to negotiate collapsed structures, find victims and assess their condition, identify potential hazards, generate maps of the structure and victim locations, and communicate with rescue personnel. These competencies bring to bear work in numerous sub-disciplines of intelligent systems (or artificial intelligence) such as sensory processing, world modeling, behavior generation, path planning, and human-robot interaction, in addition to work in communications, mechanism design and advanced sensors. In an attempt to stimulate progress in the field, reference USAR challenges are being developed and propagated worldwide. In order to make efficient use of finite research resources, the robotic USAR community must share a common understanding of what is required, technologically, to attain each competency, and have a rigorous measure of the current level of effectiveness of various technologies. NIST is working with partner organizations to measure the performance of robotic USAR competencies and technologies. In this paper, we describe the reference test arenas for USAR robots, assess the current challenges within the field, and discuss experiences thus far in the testing effort.

  5. International Safety Management – Safety Management Systems and the Challenges of Changing a Culture

    Directory of Open Access Journals (Sweden)

    Gregory Hanchrow

    2017-03-01

    Full Text Available Over the past generation, the ISM code has brought forth tremendous opportunities to investigate and enhance the human factor in shipping through the implementation of Safety Management Systems. One of the critical factors to this implementation has been mandatory compliance and a requirement for obtaining a Document of Compliance (DOC for vessels operating globally or at least internationally. A primary objective of these systems is to maintain them as “living” or “dynamic” systems that are always evolving. As the ISM code has evolved, there have been instances where large organizations have opted to maintain a voluntary DOC from their respective class society. This has been accomplished with a large human factor element as typically an organizational culture does not always accept change readily especially if there is not a legal requirement to do so. In other words, when considering maritime training is it possible that organizations may represent cultural challenges? The intent of this paper will be to research large maritime operations that have opted for a document of compliance voluntarily and compare them to similar organizations that have been mandated by international law to do the same. The result should be to gain insight into the human factors that must contribute to a culture change in the organization for the purposes of a legal requirement versus the human factors that contribute to a voluntary establishment of a safety management system. This analysis will include both the executive decision making that designs a system implementation and the operational sector that must execute its implementation. All success and failures of education and training can be determined by the outcome. Did the training achieve its goal? Or has the education prepared the students to embrace a new idea in conjunction with a company goal or a new regulatory scheme? In qualifying the goal of a successful ISM integration by examining both

  6. A Critical Appraisal of the Juvenile Justice System under Cameroon's 2005 Criminal Procedure Code: Emerging Challenges

    Directory of Open Access Journals (Sweden)

    S Tabe

    2012-03-01

    Full Text Available The objective of this article is to examine the changes introduced by the 2005 Cameroonian Criminal Procedure Code on matters of juvenile justice, considering that before this Code, juvenile justice in Cameroon was governed by extra-national laws. In undertaking this analysis, the article highlights the evolution of the administration of juvenile justice 50 years after independence of Cameroon. It also points out the various difficulties and shortcomings in the treatment of juvenile offenders in Cameroon since the enactment of the new Criminal Procedure Code. The article reveals that the 2005 Code is an amalgamation of all hitherto existing laws in the country that pertained to juvenile justice, and that despite the considerable amount of criticism it has received, the Code is clearly an improvement of the system of juvenile justice in Cameroon, since it represents a balance of the due process rights of young people, the protection of society and the special needs of young offenders. This is so because the drafters of the Code took a broad view of the old laws on juvenile justice. Also a wide range of groups were consulted, including criminal justice professionals, children’s service organisations, victims, parents, young offenders, educators, advocacy groups and social-policy analysts. However, to address the challenges that beset the juvenile justice system of Cameroon, the strategy of the government should be focussed on three areas: the prevention of youth crime, the provision of meaningful consequences for the actions of young people, and the rehabilitation and reintegration of young offenders. Cameroonian law should seek educative solutions rather than to impose prison sentences or other repressive measures on young offenders. Special courts to deal with young offenders should be established outside the regular penal system and should be provided with resources that are adequate for and appropriate to fostering their understanding of

  7. Parasite management extension - challenging traditional practice through adoption of a systems approach.

    Science.gov (United States)

    Wilson, L; Rhodes, A P; Dodunski, G

    2015-11-01

    The drivers for anthelmintic use today are substantial and anthelmintic use has become an embedded normalised behaviour. The cheapness and easy availability of anthelmintic products has meant that New Zealand farmers have had access to easy "solutions" for dealing with parasites and minimal forward planning or system redesign has been required. Despite 30 years of messaging about the emerging issue of anthelmintic resistance, management to reduce parasitism and the need to change behaviour, farmer practice has largely remained unchanged. Traditional approaches to extension, particularly around parasite management, appear to have been quite ineffective, apart from encouraging change in anthelmintic products and a switch to use of anthelmintics in combination. More effective approaches are required. The evolving nature of anthelmintic resistance and sustainable management of parasitism require attitudes, knowledge and behaviour to change. This is a challenge for all players in the industry; researchers, manufacturers and sellers, advisors and farmers. Looking beyond agriculture to the health sector provides some insight into models of decision making and behaviour change that can inform future strategies. Features in the health belief model including concepts of self-efficacy and cues to action appear to align with the issues, challenges and culture prevailing in farming, and parasite management in particular. Programmes through which farmers have made substantial beneficial behaviour change and the lessons learnt are discussed. Effecting consistent behaviour change around parasite management will involve new approaches by all participants in the process. And the process itself also needs to change. It requires an understanding of whole-farm systems, and the consideration of all the sources of influence on the farmer and the other participants in the process. The process of knowledge sharing involving the farmer should be based on equality; each person in the process

  8. Synergies, strengths and challenges: findings on community capability from a systematic health systems research literature review.

    Science.gov (United States)

    George, Asha S; Scott, Kerry; Mehra, Vrinda; Sriram, Veena

    2016-11-15

    Community capability is the combined influence of a community's social systems and collective resources that can address community problems and broaden community opportunities. We frame it as consisting of three domains that together support community empowerment: what communities have; how communities act; and for whom communities act. We sought to further understand these domains through a secondary analysis of a previous systematic review on community participation in health systems interventions in low and middle income countries (LMICs). We searched for journal articles published between 2000 and 2012 related to the concepts of "community", "capability/participation", "health systems research" and "LMIC." We identified 64 with rich accounts of community participation involving service delivery and governance in health systems research for thematic analysis following the three domains framing community capability. When considering what communities have, articles reported external linkages as the most frequently gained resource, especially when partnerships resulted in more community power over the intervention. In contrast, financial assets were the least mentioned, despite their importance for sustainability. With how communities act, articles discussed challenges of ensuring inclusive participation and detailed strategies to improve inclusiveness. Very little was reported about strengthening community cohesiveness and collective efficacy despite their importance in community initiatives. When reviewing for whom communities act, the importance of strong local leadership was mentioned frequently, while conflict resolution strategies and skills were rarely discussed. Synergies were found across these elements of community capability, with tangible success in one area leading to positive changes in another. Access to information and opportunities to develop skills were crucial to community participation, critical thinking, problem solving and ownership. Although

  9. The Challenge of Providing Safe Water with an Intermittently Supplied Piped Water Distribution System

    Science.gov (United States)

    Kumpel, E.; Nelson, K. L.

    2012-12-01

    An increasing number of urban residents in low- and middle-income countries have access to piped water; however, this water is often not available continuously. 84% of reporting utilities in low-income countries provide piped water for fewer than 24 hours per day (van den Berg and Danilenko, 2010), while no major city in India has continuous piped water supply. Intermittent water supply leaves pipes vulnerable to contamination and forces households to store water or rely on alternative unsafe sources, posing a health threat to consumers. In these systems, pipes are empty for long periods of time and experience low or negative pressure even when water is being supplied, leaving them susceptible to intrusion from sewage, soil, or groundwater. Households with a non-continuous supply must collect and store water, presenting more opportunities for recontamination. Upgrading to a continuous water supply, while an obvious solution to these challenges, is currently out of reach for many resource-constrained utilities. Despite its widespread prevalence, there are few data on the mechanisms causing contamination in an intermittent supply and the frequency with which it occurs. Understanding the impact of intermittent operation on water quality can lead to strategies to improve access to safe piped water for the millions of people currently served by these systems. We collected over 100 hours of continuous measurements of pressure and physico-chemical water quality indicators and tested over 1,000 grab samples for indicator bacteria over 14 months throughout the distribution system in Hubli-Dharwad, India. This data set is used to explore and explain the mechanisms influencing water quality when piped water is provided for a few hours every 3-5 days. These data indicate that contamination occurs along the distribution system as water travels from the treatment plant to reservoirs and through intermittently supplied pipes to household storage containers, while real

  10. Synergies, strengths and challenges: findings on community capability from a systematic health systems research literature review

    Directory of Open Access Journals (Sweden)

    Asha S. George

    2016-11-01

    Full Text Available Abstract Background Community capability is the combined influence of a community’s social systems and collective resources that can address community problems and broaden community opportunities. We frame it as consisting of three domains that together support community empowerment: what communities have; how communities act; and for whom communities act. We sought to further understand these domains through a secondary analysis of a previous systematic review on community participation in health systems interventions in low and middle income countries (LMICs. Methods We searched for journal articles published between 2000 and 2012 related to the concepts of “community”, “capability/participation”, “health systems research” and “LMIC.” We identified 64 with rich accounts of community participation involving service delivery and governance in health systems research for thematic analysis following the three domains framing community capability. Results When considering what communities have, articles reported external linkages as the most frequently gained resource, especially when partnerships resulted in more community power over the intervention. In contrast, financial assets were the least mentioned, despite their importance for sustainability. With how communities act, articles discussed challenges of ensuring inclusive participation and detailed strategies to improve inclusiveness. Very little was reported about strengthening community cohesiveness and collective efficacy despite their importance in community initiatives. When reviewing for whom communities act, the importance of strong local leadership was mentioned frequently, while conflict resolution strategies and skills were rarely discussed. Synergies were found across these elements of community capability, with tangible success in one area leading to positive changes in another. Access to information and opportunities to develop skills were crucial to community

  11. Uses of Data on Child Outcomes and Program Processes in Early Childhood Accountability Systems: Assumptions, Challenges, and Consequences.

    OpenAIRE

    John M. Love

    2006-01-01

    This paper examines a number of issues crucial in establishing state early childhood accountability systems. The author notes that these systems require careful consideration of who will be using the results and how the results are likely to be used. Challenges exist in attributing outcomes to program characteristics, implementing a large system with limited resources, and anticipating negative unintended consequences. The paper concludes with five actions that can lead to effective accountab...

  12. Panoramic view of challenges and opportunities for primary healthcare systems in Pakistan

    International Nuclear Information System (INIS)

    Sharif, H.; Sughra, U.; Butt, Z.

    2016-01-01

    Pakistan has a broad system of primary health care facilities to achieve mission of Health for all. Over the last seven years health expenditure by government of Pakistan has been increased to attain this goal. This study was conducted with the aim to assess all blocks of service readiness (basic equipment, basic amenities, laboratory capacity, standard precautions and essential medicines) in public-primary health care facilities of tehsil Rawalpindi, Pakistan. Methods: A cross-sectional survey was carried out utilizing two separate structured questionnaires for basic health units and rural health centres. Information was collected from administrative heads along with other staff where required, of all public-primary health care facilities of Tehsil Rawalpindi. Data were analysed by using SPSS version17. Results: A total of 26 health facilities were assessed; only 56% BHUs had a sign board that was available in readable form. BHUs with women medical officer as administrative head constituted 52%. Backup for electricity and toilet were the most neglected areas. Basic amenities, standard precautions and laboratory capacity of Basic Health Units (BHUs) showed a clear deviation from standards and is thus a challenge for Pakistan's Primary Health care (PHC). On the other hand for Rural Health Centres (RHCs), most were on the way to meet expectations. Conclusion: Pakistan's government is undoubtedly putting efforts in order to achieve targets of primary healthcare but it needs better mainstreaming of political, institutional and social commitments with modified standards for PHC. (author)

  13. Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge

    DEFF Research Database (Denmark)

    Salvesen, Øyvind; Reiten, Malin R; Heegaard, Peter M. H.

    2016-01-01

    Sepsis is a serious health problem associated with a range of infectious diseases in animals and humans. Early events of this syndrome can be mimicked by experimental administration of lipopolysaccharides (LPS). Compared with mice, small ruminants and humans are highly sensitive to LPS, making go...... insights into the dynamic regulation of innate immune genes, as well as raising new questions regarding the importance of ISGs and extrahepatic APPs in leukocytes after systemic endotoxin challenge....... goats valuable in inflammatory models. We performed a longitudinal study in eight Norwegian dairy goats that received LPS (0.1 μg/kg, Escherichia coli O26:B6) intravenously. A control group of five goats received corresponding volumes of sterile saline. Clinical examinations were performed continuously...... with the acute phase response, type I interferon signaling, LPS cascade and apoptosis, in addition to cytokines and chemokines were targeted. Pro-inflammatory genes, such as IL1B, CCL3 and IL8, were significantly up-regulated. Interestingly, increased mRNA levels of seven interferon stimulated genes (ISGs) were...

  14. Health Management Information System utilization in Pakistan: challenges, pitfalls and the way forward.

    Science.gov (United States)

    Qazi, Muhammad Suleman; Ali, Moazzam

    2011-12-01

    Use of data generated through the Health Management Information System (HMIS) in decision making has been facing various challenges ever since its inception in Pakistan. This descriptive qualitative study attempts to explore the perceptions of health managers to identify the status and issues in use of HMIS. Overall 26 managers (all men, ages ranging from 26 to 49 years; selected from federal level (2), provincial (4) and seven selected districts (20) from all four provinces) were interviewed face to face. The respondents identified a number of hurdles resulting in non-use, misuse and disuse of data. These included limited scope of HMIS, dubious data quality, political motives behind demand of data and an element of corruption in data reporting etc. A great deal of political and administrative will is required to institutionalize transparency in decision making in health management and HMIS is an important tool for doing so. Appropriate legislation and regulations are needed to create a conducive policy environment that would help in changing the existing decision making culture. The effective use of information requires that besides capacity development of district health managers in understanding and use of data, the higher level decision makers are provided with relevant data timely and in an easily understandable form along with the recommended actions pertinent to this data.

  15. Polypharmacy: a challenge for the primary health care of the Brazilian Unified Health System.

    Science.gov (United States)

    Nascimento, Renata Cristina Rezende Macedo do; Álvares, Juliana; Guerra, Augusto Afonso; Gomes, Isabel Cristina; Silveira, Micheline Rosa; Costa, Ediná Alves; Leite, Silvana Nair; Costa, Karen Sarmento; Soeiro, Orlando Mario; Guibu, Ione Aquemi; Karnikowski, Margô Gomes de Oliveira; Acurcio, Francisco de Assis

    2017-11-13

    To characterize the polypharmacy in primary health care patients and to identify its associated factors. This is a cross-sectional, exploratory, and evaluative study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). The variable of interest was polypharmacy, defined as the use of five or more medicines. We sought to identify the association of sociodemographic variables and indicators of health conditions to polypharmacy. For group comparison, the Pearson's Chi-square test was used. The association between polypharmacy and explanatory variables was evaluated by logistic regression model (p < 0.05). The quality of the adjustment was verified by Hosmer-Lemeshow test. The prevalence of polypharmacy among medicine users was 9.4% (95%CI 7.8-12.0) in the general population and 18.1% (95%CI 13.6-22.8) in older adults above 65 years old. We found statistically significant association between polypharmacy and age above 45 years, lower self-perception of health, presence of chronic diseases, having health insurance, care in emergency services, and region of the Country. South users presented the highest chances to polypharmacy. The most used medicines were those of the cardiovascular system, being compatible with the national epidemiological profile. Polypharmacy is a reality in the population met within the primary care of Brazilian Unified Health System and may be related to excessive or inappropriate use of medicines. The main challenge to qualify health care is to ensure that prescription of multiple medicines be appropriate and safe.

  16. ICTs and the challenge of health system transition in low and middle-income countries.

    Science.gov (United States)

    Bloom, Gerald; Berdou, Evangelia; Standing, Hilary; Guo, Zhilei; Labrique, Alain

    2017-08-07

    The aim of this paper is to contribute to debates about how governments and other stakeholders can influence the application of ICTs to increase access to safe, effective and affordable treatment of common illnesses, especially by the poor. First, it argues that the health sector is best conceptualized as a 'knowledge economy'. This supports a broadened view of health service provision that includes formal and informal arrangements for the provision of medical advice and drugs. This is particularly important in countries with a pluralistic health system, with relatively underdeveloped institutional arrangements. It then argues that reframing the health sector as a knowledge economy allows us to circumvent the blind spots associated with donor-driven ICT-interventions and consider more broadly the forces that are driving e-health innovations. It draws on small case studies in Bangladesh and China to illustrate new types of organization and new kinds of relationship between organizations that are emerging. It argues that several factors have impeded the rapid diffusion of ICT innovations at scale including: the limited capacity of innovations to meet health service needs, the time it takes to build new kinds of partnership between public and private actors and participants in the health and communications sectors and the lack of a supportive regulatory environment. It emphasises the need to understand the political economy of the digital health knowledge economy and the new regulatory challenges likely to emerge. It concludes that governments will need to play a more active role to facilitate the diffusion of beneficial ICT innovations at scale and ensure that the overall pattern of health system development meets the needs of the population, including the poor.

  17. Opportunities and challenges for 3D printing of solid-state lighting systems

    Science.gov (United States)

    Narendran, Nadarajah; Perera, Indika U.; Mou, Xi; Thotagamuwa, Dinusha R.

    2017-09-01

    Low energy use and reduced maintenance have made the LED, a solid-state light (SSL) source, the preferred technology for many lighting applications. With the explosion of products in the marketplace and subsequent price erosion, manufacturers are looking for lower cost materials and manufacturing methods. 3-D printing, also known as additive manufacturing, could be a potential solution. Recently, manufacturers in the automotive, aerospace, and medical industries have embraced 3-D printing for manufacturing parts and systems. This could pave the way for the lighting industry to produce lower cost, custom lighting systems that are 3-D printed on-site to achieve on-time and on-demand manufacturing. One unique aspect of LED fixture manufacturing is that it requires thermo-mechanical, electrical, and optical components. The goal of our investigation was to understand if current 3-D printing technologies and materials can be used to manufacture functional thermo-mechanical, electrical, and optical components for SSL fixtures. We printed heat sink components and electrical traces using an FFF-type 3-D printer with different filaments. The results showed that the printed heat sinks achieved higher thermal conductivity values compared to components made with plastic materials. For electrical traces, graphene-infused PLA showed low resistivity but it is much higher than bulk copper resistivity. For optics, SLA-printed optical components showed that print resolution, print orientation, and postprocessing affect light transmission and light scatter properties. Overall, 3-D printing offers an opportunity for mass customization of SSL fixtures and changing architectural lighting practice, but several challenges in terms of process and materials still have to be overcome.

  18. Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

    Directory of Open Access Journals (Sweden)

    Attila Oláh

    2017-11-01

    Full Text Available It is well known that certain active ingredients of the plants of Cannabis genus, i.e., the “phytocannabinoids” [pCBs; e.g., (−-trans-Δ9-tetrahydrocannabinol (THC, (−-cannabidiol, etc.] can influence a wide array of biological processes, and the human body is able to produce endogenous analogs of these substances [“endocannabinoids” (eCB, e.g., arachidonoylethanolamine (anandamide, AEA, 2-arachidonoylglycerol (2-AG, etc.]. These ligands, together with multiple receptors (e.g., CB1 and CB2 cannabinoid receptors, etc., and a complex enzyme and transporter apparatus involved in the synthesis and degradation of the ligands constitute the endocannabinoid system (ECS, a recently emerging regulator of several physiological processes. The ECS is widely expressed in the human body, including several members of the innate and adaptive immune system, where eCBs, as well as several pCBs were shown to deeply influence immune functions thereby regulating inflammation, autoimmunity, antitumor, as well as antipathogen immune responses, etc. Based on this knowledge, many in vitro and in vivo studies aimed at exploiting the putative therapeutic potential of cannabinoid signaling in inflammation-accompanied diseases (e.g., multiple sclerosis or in organ transplantation, and to dissect the complex immunological effects of medical and “recreational” marijuana consumption. Thus, the objective of the current article is (i to summarize the most recent findings of the field; (ii to highlight the putative therapeutic potential of targeting cannabinoid signaling; (iii to identify open questions and key challenges; and (iv to suggest promising future directions for cannabinoid-based drug development.

  19. Overview of main challenges for Early Warning Systems for Food Security in West Africa

    Science.gov (United States)

    Genesio, Lorenzo; Bacci, Maurizio; Baron, Christian; Diarra, Birama; di Vecchia, Andrea; Traoré, Seydou; Hassane, Idrissa; Ndiaye, Mamadou; Philippon, Nathalie; Tarchiani, Vieri

    2010-05-01

    In West Africa Early Warning Systems (EWSs) for food security have been widely recognized to have contributed in the last twenty years to better face famine emergencies. The improved understanding of the environmental and socio-economic dynamics of the region, a change in the causes for food insecurity and the evolution of Information and Communication Technologies (ICT) have favored the introduction of new approaches and the involvement of a network of stakeholders. In recent years the improvement of EWS has been concentrated in the adaptation and the transfer of existing tools rather than the development of the overall design of EWS in function of users needs, at the same time key scientific areas to be improved to provide major operational advancements needs to be better identified. This partially due to a difficulty of the research community to be in direct connection with operational processes and on the other side by an evident limit in following a demand driven approach due to the difficulties in modelling bio and social phenomena in a unique environment. In this context AMMA project had the ambitious objective of bridging the gap between state of the art research in the domains of geo-science and human related disciplines, and the operational EWS. The work carried out in AMMA, while improving the understanding of monsoon system, allowed to better orient research challenges in order to provide EWS with improved products effectively meeting the needs of end-users at different levels. In this work, advancements in providing appropriate information for the identification of agricultural risk zones by using short to long time forecasts are illustrated highlighting critical aspects still demanding scientific improvements.

  20. Health system governance to support integrated mental health care in South Africa: challenges and opportunities.

    Science.gov (United States)

    Marais, Debra Leigh; Petersen, Inge

    2015-01-01

    While South Africa has a new policy framework supporting the integration of mental health care into primary health care, this is not sufficient to ensure transformation of the health care system towards integrated primary mental health care. Health systems strengthening is needed, incorporating, inter alia, capacity building and resource inputs, as well as good governance for ensuring that the relevant policy imperatives are implemented. To identify systemic factors within institutional and policy contexts that are likely to facilitate or impede the implementation of integrated mental health care in South Africa. Semi-structured qualitative interviews were conducted with 17 key stakeholders in the Department of Health and Department of Social Development at national level, at provincial level in the North West Province, and at district level in the Dr Kenneth Kaunda district. Participants were purposively identified based on their positions and job responsibilities. Interview questions were guided by a hybrid of Siddiqi et al.'s governance framework principles and Mikkelsen-Lopez et al.'s health system governance approach. Data were analysed using framework analysis in NVivo. Facilitative factors included the recent mental health care policy framework and national action plan that embraces integrated care using a task sharing model and provides policy imperatives for the establishment of district mental health teams to facilitate the development and implementation of district mental health care plans; the roll out of the integrated chronic disease service delivery platform that can be leveraged to increase access and resources as well as decrease stigma; and the presence of NGOs that can assist with service delivery. Challenges included the low prioritisation and stigmatisation of mental illness; weak managerial and planning capacity to develop and implement mental health care plans at provincial and district level; poor pre-service training of generalists in

  1. Performance-Based Financing to Strengthen the Health System in Benin: Challenging the Mainstream Approach

    Directory of Open Access Journals (Sweden)

    Elisabeth Paul

    2018-01-01

    sustainability issues are also discussed. Conclusion BTC’s alternative PBF approach is both promising in terms of effects, ownership and sustainability, and less resource consuming. This experience testifies that PBF is not a uniform or rigid model, and opens the policy ground for recipient governments to put their own emphasis and priorities and design ad hoc models adapted to their context specificities. However, integrating PBF within the normal functioning of local health systems, in line with other reforms, is a big challenge.

  2. Applied & Computational MathematicsChallenges for the Design and Control of Dynamic Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D L; Burns, J A; Collis, S; Grosh, J; Jacobson, C A; Johansen, H; Mezic, I; Narayanan, S; Wetter, M

    2011-03-10

    ) Installation and commissioning - Current methodology and tools can target a three month window for commissioning of building subsystems; what is needed is one week. A 10X improvement is needed. (3) Quality - Current design tools can achieve 30% accuracy; what is needed to make design decisions is 5% with quantification of uncertainty. A 5X improvement is needed. These challenges cannot be overcome by raw computational power alone and require the development of new algorithms. Here algorithms mean much more than simulating the building physics but need to be inclusive of a much better understanding of the building and the control systems associated with the building and to capture the entire set of dynamics. The algorithmsmust represent computationally new mathematical approaches to modeling, simulation, optimization and control of large multi-scale dynamic systems and bringing these elements to bear on industry in simulation enabled design approaches.

  3. Challenges in the use of the mental health information system in a resource-limited setting: lessons from Ghana.

    Science.gov (United States)

    Kpobi, Lily; Swartz, Leslie; Ofori-Atta, Angela L

    2018-02-08

    One of the most successful modes of record-keeping and data collection is the use of health management information systems, where patient information and management plans are uniformly entered into a database to streamline the information and for ease of further patient management. For mental healthcare, a Mental Health Information System (MHIS) has been found most successful since a properly established and operational MHIS is helpful for developing equitable and appropriate mental health care systems. Until 2010, the system of keeping patient records and information in the Accra Psychiatric Hospital of Ghana was old and outdated. In light of this and other factors, a complete reforming of the mental health information systems in three psychiatric hospitals in Ghana was undertaken in 2010. Four years after its implementation, we explored user experiences with the new system, and report here the challenges that were identified with use of the new MHIS. Individual semi-structured interviews were conducted with nine clinical and administrative staff of the Accra Psychiatric Hospital to examine their experiences with the new MHIS. Participants in the study were in three categories: clinical staff, administrator, and records clerk. Participants' knowledge of the system and its use, as well as the challenges they had experienced in its use were explored using an interpretative phenomenological approach. The data suggest that optimal use of the current MHIS had faced significant implementation challenges in a number of areas. Central challenges reported by users included increased workload, poor staff involvement and training, and absence of logistic support to keep the system running. Setting up a new system does not guarantee its success. As important as it is to have a mental health information system, its usefulness is largely dependent on proper implementation and maintenance. Further, the system can facilitate policy transformation only when the place of mental

  4. Challenges with the introduction of radio-frequency identification systems into a manufacturer's supply chain - a pilot study

    Science.gov (United States)

    Kumar, Sameer; Kadow, Brooke B.; Lamkin, Melissa K.

    2011-05-01

    As radio-frequency identification (RFID) implementation becomes more widespread it is important for managers to consider if this technology is right for their businesses. This study examines challenges of RFID implementation along with a cost-benefit analysis of a pharmaceuticals manufacturer's supply chain. Research was gathered from a variety of sources on the topic of RFID to provide an in-depth analysis of challenges and benefits found with RFID systems. Furthermore, the study reviews the real case applications of the RFID technology in healthcare and customer services. Many of the challenges with RFID stem from improper planning of the synchronisation of the supply chain and the integration of RFID technology into facilities and software systems. Customer privacy, excess information and obsolete technology are also of concern to companies considering RFID. Benefits such as increased information sharing, product visibility and real-time information help to offset these challenges. In addition, pharmaceuticals manufacturer real case application showed cost savings from reducing labour and decreased opportunities for lost product counteract the expense to implement an RFID system. This study will be of value to managers who are attempting to implement RFID technology in their companies. It is intended that readers, both academics and practitioners, will be able to identify possible challenges and mitigate them as the RFID technology is put into practice.

  5. Challenges, problems and possible solutions in wind generator systems from the aspect of forecast, planning and delivery of wind energy

    International Nuclear Information System (INIS)

    Giovski, Nikola

    2014-01-01

    The fundamental difficulties of integrating wind energy into the power system arise from its large temporal variability and limited predictability. That's why the integration of wind power presents major challenge for today's operating and planning practices of the power system operators. Accurate predictions of the possible wind power output, in time intervals relevant for creating schedules for production and exchange capacity, allows to system operators and dispatching personnel more efficient power system management. Despite the challenges and problems that arise due to integration of wind power into power systems, which need to be solved or reduced, wind power has its advantages that should be utilized. The effective integration of wind power plants into the transmission grid should allow them to represent the backbone of future energy systems. Modern wind generators represent production units that have the ability to participate in the management of energy systems e.g. in the regulation of frequency, voltage and other network operating requirements. This paper provides a brief overview of global experiences with the challenges, problems and possible solutions that appear in wind generator systems from the aspect of forecasting, planning and delivery of wind energy. (author)

  6. Dynamics of immune system gene expression upon bacterial challenge and wounding in a social insect (Bombus terrestris.

    Directory of Open Access Journals (Sweden)

    Silvio Erler

    2011-03-01

    Full Text Available The innate immune system which helps individuals to combat pathogens comprises a set of genes representing four immune system pathways (Toll, Imd, JNK and JAK/STAT. There is a lack of immune genes in social insects (e.g. honeybees when compared to Diptera. Potentially, this might be compensated by an advanced system of social immunity (synergistic action of several individuals. The bumble bee, Bombus terrestris, is a primitively eusocial species with an annual life cycle and colonies headed by a single queen. We used this key pollinator to study the temporal dynamics of immune system gene expression in response to wounding and bacterial challenge.Antimicrobial peptides (AMP (abaecin, defensin 1, hymenoptaecin were strongly up-regulated by wounding and bacterial challenge, the latter showing a higher impact on the gene expression level. Sterile wounding down-regulated TEP A, an effector gene of the JAK/STAT pathway, and bacterial infection influenced genes of the Imd (relish and JNK pathway (basket. Relish was up-regulated within the first hour after bacterial challenge, but decreased strongly afterwards. AMP expression following wounding and bacterial challenge correlates with the expression pattern of relish whereas correlated expression with dorsal was absent. Although expression of AMPs was high, continuous bacterial growth was observed throughout the experiment.Here we demonstrate for the first time the temporal dynamics of immune system gene expression in a social insect. Wounding and bacterial challenge affected the innate immune system significantly. Induction of AMP expression due to wounding might comprise a pre-adaptation to accompanying bacterial infections. Compared with solitary species this social insect exhibits reduced immune system efficiency, as bacterial growth could not be inhibited. A negative feedback loop regulating the Imd-pathway is suggested. AMPs, the end product of the Imd-pathway, inhibited the up-regulation of the

  7. What do we know about the needs and challenges of health systems? A scoping review of the international literature.

    Science.gov (United States)

    Roncarolo, Federico; Boivin, Antoine; Denis, Jean-Louis; Hébert, Rejean; Lehoux, Pascale

    2017-09-08

    While there is an extensive literature on Health System (HS) strengthening and on the performance of specific HSs, there are few exhaustive syntheses of the challenges HSs are facing worldwide. This paper reports the findings of a scoping review aiming to classify the challenges of HSs investigated in the scientific literature. Specifically, it determines the kind of research conducted on HS challenges, where it was performed, in which health sectors and on which populations. It also identifies the types of challenge described the most and how they varied across countries. We searched 8 databases to identify scientific papers published in English, French and Italian between January 2000 and April 2016 that addressed HS needs and challenges. The challenges reported in the articles were classified using van Olmen et al.'s dynamic HS framework. Countries were classified using the Human Development Index (HDI). Our analyses relied on descriptive statistics and qualitative content analysis. 292 articles were included in our scoping review. 33.6% of these articles were empirical studies and 60.1% were specific to countries falling within the very high HDI category, in particular the United States. The most frequently researched sectors were mental health (41%), infectious diseases (12%) and primary care (11%). The most frequently studied target populations included elderly people (23%), people living in remote or poor areas (21%), visible or ethnic minorities (15%), and children and adolescents (15%). The most frequently reported challenges related to human resources (22%), leadership and governance (21%) and health service delivery (24%). While health service delivery challenges were more often examined in countries within the very high HDI category, human resources challenges attracted more attention within the low HDI category. This scoping review provides a quantitative description of the available evidence on HS challenges and a qualitative exploration of the

  8. Design and challenges for a tsunami early warning system in the Marmara Sea

    Science.gov (United States)

    Necmioğlu, Öcal

    2016-01-01

    Since 1900, around 90,000 people have lost their lives in 76 earthquakes in Turkey, with a total affected population of around 7 million and direct losses of around 25 billion USD. Based on a time-dependent model that includes coseismic and post-seismic effects of the 1999 Kocaeli earthquake with moment magnitude Mw = 7.4, Parsons (J Geophys Res. 109, 2004) concluded that the probability of an earthquake with Mw > 7 in the Sea of Marmara near Istanbul is 35 to 70 % in the next 30 years. According to a 2011 study, an earthquake with Mw = 7.25 on the Main Marmara Fault is expected to heavily damage or destroy 2 to 4 % of around 1,000,000 buildings in Istanbul with a population around 13 million, with 9 to 15 % of the buildings receiving medium damage and 20 to 34 % of the buildings damaged lightly (Erdik, Science 341:72, 2013). In the absence of adequate post-earthquake assembly areas especially in the heavily urbanized Istanbul, it is evident that after a major earthquake, especially in the coastal parts of the city, citizens would be storming to landfill assembly and recreational areas. Besides earthquakes, around 30 tsunamis have been reported by Altınok et al. (Natural Hazards Earth System Science 11:273-293, 2011) in the Marmara Sea. Among those, catastrophic earthquakes such as 1509, 1766, and 1894 resulted in considerable tsunamis and some damage. The latest tsunami observed in Marmara was due to a triggered submarine landslide of the 1999 Mw = 7.4 Kocaeli earthquake which led to reported run-up heights of 1-3 m in most places (Tinti et al., Marine Geology 225:311-330, 2006). In this study, I propose a design for a tsunami warning system specific for the Marmara region that is strongly coupled with the earthquake early warning system (due to the short arrival times of tsunami) and stakeholders of the tsunami mitigation activities, such as local and regional components of disaster and emergency management and civil protection units, to ensure that the citizens

  9. Employment challenges in the future

    DEFF Research Database (Denmark)

    Rimmer, Nina Roehr

    2011-01-01

    Discussion of challenges in employment challenges in Europe and a brief discription of the Danish flexicurity system......Discussion of challenges in employment challenges in Europe and a brief discription of the Danish flexicurity system...

  10. Implementing Black Box Warnings (BBWs) in Health Information Systems: An Organizing Taxonomy Identifying Opportunities and Challenges.

    Science.gov (United States)

    Ikezuagu, M; Yang, E; Daghstani, A; Kaelber, D C

    2012-01-01

    To develop a practical approach for implementing clinical decision support (CDS) for medication black box warnings (BBWs) into health information systems (HIS). We reviewed all existing medication BBWs and organized them into a taxonomy that identifies opportunities and challenges for implementing CDS for BBWs into HIS. Of the over 400 BBWs that currently exist, they can be organized into 4 categories with 9 sub-categories based on the types of information contained in the BBWs, who should be notified, and potential actions to that could be taken by the person receiving the BBW. Informatics oriented categories and sub-categories of BBWs include - interactions (13%) (drug-drug (4%) and drug-diagnosis (9%)), testing (21%) (baseline (9%) and on-going (12%)), notifications (29%) (drug prescribers (7%), drug dispensers (2%), drug administrators (9%), patients (10%), and third parties (1%)), and non-actionable (37%). This categorization helps identify BBWs for which CDS can be easily implemented into HIS today (such as drug-drug interaction BBWs), those that cannot be easily implemented into HIS today (such as non-actionable BBWs), and those where advanced and/or integrated HIS need to be in place to implement CDS for BBWs (such a drug dispensers BBWs). HIS have the potential to improve patient safety by implementing CDS for BBWs. A key to building CDS for BBWs into HIS is developing a taxonomy to serve as an organizing roadmap for implementation. The informatics oriented BBWs taxonomy presented here identified types of BBWs in which CDS can be implemented easily into HIS currently (a minority of the BBWs) and those types of BBWs where CDS cannot be easily implemented today (a majority of BBWs).

  11. Volcano alert level systems: managing the challenges of effective volcanic crisis communication

    Science.gov (United States)

    Fearnley, C. J.; Beaven, S.

    2018-05-01

    Over the last four decades, volcano observatories have adopted a number of different communication strategies for the dissemination of information on changes in volcanic behaviour and potential hazards to a wide range of user groups. These commonly include a standardised volcano alert level system (VALS), used in conjunction with other uni-valent communication techniques (such as information statements, reports and maps) and multi-directional techniques (such as meetings and telephone calls). This research, based on interviews and observation conducted 2007-2009 at the five US Geological Survey (USGS) volcano observatories, and including some of the key users of the VALS, argues for the importance of understanding how communicating volcanic hazard information takes place as an everyday social practice, focusing on the challenges of working across the boundaries between the scientific and decision-making communities. It is now widely accepted that the effective use, value and deployment of information across science-policy interfaces of this kind depend on three criteria: the scientific credibility of the information, its relevance to the needs of stakeholders and the legitimacy of both the information and the processes that produced it. Translation and two-way communication are required to ensure that all involved understand what information is credible and relevant. Findings indicate that whilst VALS play a role in raising awareness of an unfolding situation, supplementary communication techniques are crucial in facilitating situational understanding of that situation, and the uncertainties inherent to its scientific assessment, as well as in facilitating specific responses. In consequence, `best practice' recommendations eschew further standardisation, and focus on the in situ cultivation of dialogue between scientists and stakeholders as a means of ensuring that information, and the processes through which it is produced are perceived to be legitimate by all

  12. Web-based communications systems: innovate solutions to complex development challenges

    International Nuclear Information System (INIS)

    Levy, D.S.; Sordi, G.M.; Villavicencio, A.L.H.; Biazini Filho, F.

    2015-01-01

    This research work focus on the potential value of Information and Communication Technologies (ICTs) to enhance communication and education on Radiological Protection throughout Brazil. ICTs present unprecedented opportunities to innovate solutions to complex development issues, in this large country where it is a strong challenge to ensure access to information to as many people as possible, minimizing costs and optimizing results. Therefore, taking advantage of the impact of ICTs in modern Information Society and its institutions, some research works include education for workers, researchers and the public, offering conditions for learning and improving professional and personal skills. UNIPRORAD is a research work of informatization of radiological protection programs to offer unified programs and inter-related information in Portuguese. The system provides Brazilian facilities and researchers a complete repository for research, consultation and information. The content includes the best practices for optimization and monitoring programs, taking into account that in order to establish a Radiation Protection Plan or a Radiation Emergency Plan, there must be observed all procedures based on national and international recommendations published by different organizations over the past decades: International Commission on Radiological Protection (ICRP), International Atomic Energy Agency (IAEA) and National Nuclear Energy Commission (CNEN). Other than the efforts to disseminate information to radioactive facilities and researches, it is equally essential to invest in education and communication to increase public knowledge and understanding of the benefits of Nuclear Technology, such as food irradiation and social responsibility for electric power generation, for public acceptance of Nuclear Technology depends on public understanding of radiation and its effects on individuals, workers and environment. This research work aims to present several important initiatives

  13. Progress in Harmonizing Tiered HIV Laboratory Systems: Challenges and Opportunities in 8 African Countries

    Science.gov (United States)

    Williams, Jason; Umaru, Farouk; Edgil, Dianna; Kuritsky, Joel

    2016-01-01

    ABSTRACT In 2014, the Joint United Nations Programme on HIV/AIDS released its 90-90-90 targets, which make laboratory diagnostics a cornerstone for measuring efforts toward the epidemic control of HIV. A data-driven laboratory harmonization and standardization approach is one way to create efficiencies and ensure optimal laboratory procurements. Following the 2008 “Maputo Declaration on Strengthening of Laboratory Systems”—a call for government leadership in harmonizing tiered laboratory networks and standardizing testing services—several national ministries of health requested that the United States Government and in-country partners help implement the recommendations by facilitating laboratory harmonization and standardization workshops, with a primary focus on improving HIV laboratory service delivery. Between 2007 and 2015, harmonization and standardization workshops were held in 8 African countries. This article reviews progress in the harmonization of laboratory systems in these 8 countries. We examined agreed-upon instrument lists established at the workshops and compared them against instrument data from laboratory quantification exercises over time. We used this measure as an indicator of adherence to national procurement policies. We found high levels of diversity across laboratories’ diagnostic instruments, equipment, and services. This diversity contributes to different levels of compliance with expected service delivery standards. We believe the following challenges to be the most important to address: (1) lack of adherence to procurement policies, (2) absence or limited influence of a coordinating body to fully implement harmonization proposals, and (3) misalignment of laboratory policies with minimum packages of care and with national HIV care and treatment guidelines. Overall, the effort to implement the recommendations from the Maputo Declaration has had mixed success and is a work in progress. Program managers should continue efforts to

  14. Challenges and perspectives in Service Design curricula. The case of the Service Systems Design Master of Aalborg University in Copenhagen

    DEFF Research Database (Denmark)

    Götzen, Amalia De; Morelli, Nicola; Grani, Francesco

    2014-01-01

    In this paper the new Master program on Service Systems Design at Aalborg University in Copenhagen will be presented, focusing on the challenges of building such a curriculum and on its peculiar approach to Service Design through the Problem Based Learning methodology. All the semesters will be d...

  15. Introduction of Geographical Information Systems (GIS) in Technical University Education in Ghana: Challenges and the Way Forward

    Science.gov (United States)

    Acquah, Prince C.; Asamoah, Jack N.; Konadu, Daniel D.

    2017-01-01

    Geographic Information System (GIS) continue to play very important role in improving spatial thinking skills of graduates from higher educational institutions. However, teaching and learning of GIS at the technical university level in Ghana remains very limited due to some implementation challenges. This paper reviews the implementation of GIS in…

  16. Designing and Delivering Skills Transferability and Employment Mobility: The Challenges of a Market-Driven Vocational Education and Training System

    Science.gov (United States)

    Gekara, Victor; Snell, Darryn

    2018-01-01

    As job security declines and precarious employment arrangements become more prevalent, transferable skills have become vital for job seeking success. In recognition of this issue, many governments are seeking to redesign their training systems in ways that transferable skills become better emphasised. This paper examines the challenges of…

  17. Systems approach to waste governance: unpacking the challenges facing local government

    CSIR Research Space (South Africa)

    Godfrey, Linda K

    2008-09-01

    Full Text Available ; no or poor levels of service delivery; and potential environmental and human health impacts. However, these broad challenges were found to contain further primary, secondary, etc. root causes, both internal and external to the municipality. This analysis...

  18. WE-EF-BRD-02: Battling Maxwell’s Equations: Physics Challenges and Solutions for Hybrid MRI Systems

    Energy Technology Data Exchange (ETDEWEB)

    Keall, P. [University of Sydney (Australia)

    2015-06-15

    MRI-guided treatment is a growing area of medicine, particularly in radiotherapy and surgery. The exquisite soft tissue anatomic contrast offered by MRI, along with functional imaging, makes the use of MRI during therapeutic procedures very attractive. Challenging the utility of MRI in the therapy room are many issues including the physics of MRI and the impact on the environment and therapeutic instruments, the impact of the room and instruments on the MRI; safety, space, design and cost. In this session, the applications and challenges of MRI-guided treatment will be described. The session format is: Past, present and future: MRI-guided radiotherapy from 2005 to 2025: Jan Lagendijk Battling Maxwell’s equations: Physics challenges and solutions for hybrid MRI systems: Paul Keall I want it now!: Advances in MRI acquisition, reconstruction and the use of priors to enable fast anatomic and physiologic imaging to inform guidance and adaptation decisions: Yanle Hu MR in the OR: The growth and applications of MRI for interventional radiology and surgery: Rebecca Fahrig Learning Objectives: To understand the history and trajectory of MRI-guided radiotherapy To understand the challenges of integrating MR imaging systems with linear accelerators To understand the latest in fast MRI methods to enable the visualisation of anatomy and physiology on radiotherapy treatment timescales To understand the growing role and challenges of MRI for image-guided surgical procedures My disclosures are publicly available and updated at: http://sydney.edu.au/medicine/radiation-physics/about-us/disclosures.php.

  19. Mulching methods impact on herb production and weed control in a certified organic production system

    Science.gov (United States)

    Weed control challenges for horticulture production are formidable; however, these challenges are even greater for those considering organic crop production. Black plastic as a weed barrier is widely used and effective. The expense associated with black plastic, as well as the ecological impact of...

  20. Key challenges and recent progress in batteries, fuel cells, and hydrogen storage for clean energy systems

    Science.gov (United States)

    Chalk, Steven G.; Miller, James F.

    Reducing or eliminating the dependency on petroleum of transportation systems is a major element of US energy research activities. Batteries are a key enabling technology for the development of clean, fuel-efficient vehicles and are key to making today's hybrid electric vehicles a success. Fuel cells are the key enabling technology for a future hydrogen economy and have the potential to revolutionize the way we power our nations, offering cleaner, more efficient alternatives to today's technology. Additionally fuel cells are significantly more energy efficient than combustion-based power generation technologies. Fuel cells are projected to have energy efficiency twice that of internal combustion engines. However before fuel cells can realize their potential, significant challenges remain. The two most important are cost and durability for both automotive and stationary applications. Recent electrocatalyst developments have shown that Pt alloy catalysts have increased activity and greater durability than Pt catalysts. The durability of conventional fluorocarbon membranes is improving, and hydrocarbon-based membranes have also shown promise of equaling the performance of fluorocarbon membranes at lower cost. Recent announcements have also provided indications that fuel cells can start from freezing conditions without significant deterioration. Hydrogen storage systems for vehicles are inadequate to meet customer driving range expectations (>300 miles or 500 km) without intrusion into vehicle cargo or passenger space. The United States Department of Energy has established three centers of Excellence for hydrogen storage materials development. The centers are focused on complex metal hydrides that can be regenerated onboard a vehicle, chemical hydrides that require off-board reprocessing, and carbon-based storage materials. Recent developments have shown progress toward the 2010 DOE targets. In addition DOE has established an independent storage material testing center

  1. Policy challenges for the pediatric rheumatology workforce: Part II. Health care system delivery and workforce supply

    Directory of Open Access Journals (Sweden)

    Henrickson Michael

    2011-08-01

    Full Text Available Abstract The United States pediatric population with chronic health conditions is expanding. Currently, this demographic comprises 12-18% of the American child and youth population. Affected children often receive fragmented, uncoordinated care. Overall, the American health care delivery system produces modest outcomes for this population. Poor, uninsured and minority children may be at increased risk for inferior coordination of services. Further, the United States health care delivery system is primarily organized for the diagnosis and treatment of acute conditions. For pediatric patients with chronic health conditions, the typical acute problem-oriented visit actually serves as a barrier to care. The biomedical model of patient education prevails, characterized by unilateral transfer of medical information. However, the evidence basis for improvement in disease outcomes supports the use of the chronic care model, initially proposed by Dr. Edward Wagner. Six inter-related elements distinguish the success of the chronic care model, which include self-management support and care coordination by a prepared, proactive team. United States health care lacks a coherent policy direction for the management of high cost chronic conditions, including rheumatic diseases. A fundamental restructure of United States health care delivery must urgently occur which places the patient at the center of care. For the pediatric rheumatology workforce, reimbursement policies and the actions of health plans and insurers are consistent barriers to chronic disease improvement. United States reimbursement policy and overall fragmentation of health care services pose specific challenges for widespread implementation of the chronic care model. Team-based multidisciplinary care, care coordination and self-management are integral to improve outcomes. Pediatric rheumatology demand in the United States far exceeds available workforce supply. This article reviews the career

  2. Policy challenges for the pediatric rheumatology workforce: Part II. Health care system delivery and workforce supply.

    Science.gov (United States)

    Henrickson, Michael

    2011-01-01

    The United States pediatric population with chronic health conditions is expanding. Currently, this demographic comprises 12-18% of the American child and youth population. Affected children often receive fragmented, uncoordinated care. Overall, the American health care delivery system produces modest outcomes for this population. Poor, uninsured and minority children may be at increased risk for inferior coordination of services. Further, the United States health care delivery system is primarily organized for the diagnosis and treatment of acute conditions. For pediatric patients with chronic health conditions, the typical acute problem-oriented visit actually serves as a barrier to care. The biomedical model of patient education prevails, characterized by unilateral transfer of medical information. However, the evidence basis for improvement in disease outcomes supports the use of the chronic care model, initially proposed by Dr. Edward Wagner. Six inter-related elements distinguish the success of the chronic care model, which include self-management support and care coordination by a prepared, proactive team. United States health care lacks a coherent policy direction for the management of high cost chronic conditions, including rheumatic diseases. A fundamental restructure of United States health care delivery must urgently occur which places the patient at the center of care. For the pediatric rheumatology workforce, reimbursement policies and the actions of health plans and insurers are consistent barriers to chronic disease improvement. United States reimbursement policy and overall fragmentation of health care services pose specific challenges for widespread implementation of the chronic care model. Team-based multidisciplinary care, care coordination and self-management are integral to improve outcomes. Pediatric rheumatology demand in the United States far exceeds available workforce supply. This article reviews the career choice decision-making process

  3. EUROPEAN PENSION SYSTEMS - THE REAL CHALLENGE OF THE 21ST CENTURY

    Directory of Open Access Journals (Sweden)

    Maria Augusztinovics

    2003-07-01

    Full Text Available It will be argued that the present focus of the pension reform debate - public, pay-as-you-go versus private, funded - is misplaced and somewhat outdated. Pay-as-you-go versus funding or pre-funding is a more-or-less technical issue. The public versus private choice should be seen as a cost-benefit, efficiency problem. These two dichotomies represent important, but secondary problems. (They cannot even be expected to help solving the certainly serious - although not that catastrophic as often painted - problems caused by the foreseeable demographic changes, the so-called ageing of the population. The major distinctive attribute of existing European pension schemes is not the mode of financing or management. It is the Bismarckian heritage, the close link to employment, based on the typically 20th century-type, continuous working career. A presently emerging trend, however, is the transformation of the labour market. The so-called "atypical" forms of employment (part-time work, outsourcing, work at home, fixed-length contracts, etc. are spreading and the traditional employer-employee link is weakening, if not - at least partially - disappearing. Activity ratios (poorly represented by the unemployment rate are declining. This trend will probably be accentuated by the deepening of globalization and European integration, the growing importance of migration, including temporary migration (i.e. working in one country for a few years, then in another one, then maybe returning home for retirement. The questions thus arise: how, when, where will people, who are economically "inactive" or wandering around during a large faction of their earning span, acquire pension eligibility, sufficient for income security in old age? Will the present forms of pension insurance (including social security as well as country-based private funds be able to live up to this 21st century-type of challenge? If not, what are the adequate models for the future and what are the

  4. Liquid lithium loop system to solve challenging technology issues for fusion power plant

    Science.gov (United States)

    Ono, M.; Majeski, R.; Jaworski, M. A.; Hirooka, Y.; Kaita, R.; Gray, T. K.; Maingi, R.; Skinner, C. H.; Christenson, M.; Ruzic, D. N.

    2017-11-01

    Steady-state fusion power plant designs present major divertor technology challenges, including high divertor heat flux both in steady-state and during transients. In addition to these concerns, there are the unresolved technology issues of long term dust accumulation and associated tritium inventory and safety issues. It has been suggested that radiation-based liquid lithium (LL) divertor concepts with a modest lithium-loop could provide a possible solution for these outstanding fusion reactor technology issues, while potentially improving reactor plasma performance. The application of lithium (Li) in NSTX resulted in improved H-mode confinement, H-mode power threshold reduction, and reduction in the divertor peak heat flux while maintaining essentially Li-free core plasma operation even during H-modes. These promising results in NSTX and related modeling calculations motivated the radiative liquid lithium divertor concept and its variant, the active liquid lithium divertor concept, taking advantage of the enhanced or non-coronal Li radiation in relatively poorly confined divertor plasmas. To maintain the LL purity in a 1 GW-electric class fusion power plant, a closed LL loop system with a modest circulating capacity of ~1 l s-1 is envisioned. We examined two key technology issues: (1) dust or solid particle removal and (2) real time recovery of tritium from LL while keeping the tritium inventory level to an acceptable level. By running the LL-loop continuously, it can carry the dust particles and impurities generated in the vacuum vessel to the outside where the dust/impurities can be removed by relatively simple dust filter, cold trap and/or centrifugal separation systems. With ~1 l s-1 LL flow, even a small 0.1% dust content by weight (or 0.5 g s-1) suggests that the LL-loop could carry away nearly 16 tons of dust per year. In a 1 GW-electric (or ~3 GW fusion power) fusion power plant, about 0.5 g s-1 of tritium is needed to maintain the fusion fuel cycle

  5. Prevention of Congenital Transmission of Malaria in Sub-Saharan African Countries: Challenges and Implications for Health System Strengthening

    OpenAIRE

    Osungbade, Kayode O.; Oladunjoye, Olubunmi O.

    2012-01-01

    Objectives. Review of burden of congenital transmission of malaria, challenges of preventive measures, and implications for health system strengthening in sub-Saharan Africa. Methods. Literature from Pubmed (MEDLINE), Biomed central, Google Scholar, and Cochrane Database were reviewed. Results. The prevalence of congenital malaria in sub-Saharan Africa ranges from 0 to 23%. Diagnosis and existing preventive measures are constantly hindered by weak health systems and sociocultural issues. WHO ...

  6. Change as a Service: Challenges and Effects of a New Paradigm for Library Systems and Content Infrastructure

    OpenAIRE

    Forsman, Daniel

    2012-01-01

    The infrastructure for supplying information resources to higher education and research has gone through dramatic changes the last 15 years. The amount of electronic resources available and library systems that handle them have multiplied leaving libraries in a challenging situation. We are coping with a changing definition of library collections, changing business models for owning and accessing materials as well as a shift in the architecture of library systems. The Library at Chalmers U...

  7. WE-AB-201-01: Treatment Planning System Commissioning and QA: Challenges and Opportunities

    International Nuclear Information System (INIS)

    Salomons, G.

    2015-01-01

    Treatment planning systems (TPS) are a cornerstone of modern radiation therapy. Errors in their commissioning or use can have a devastating impact on many patients. To support safe and high quality care, medical physicists must conduct efficient and proper commissioning, good clinical integration, and ongoing quality assurance (QA) of the TPS. AAPM Task Group 53 and related publications have served as seminal benchmarks for TPS commissioning and QA over the past two decades. Over the same time, continuing innovations have made the TPS even more complex and more central to the clinical process. Medical goals are now expressed in terms of the dose and margins around organs and tissues that are delineated from multiple imaging modalities (CT, MR and PET); and even temporally resolved (i.e., 4D) imaging. This information is passed on to optimization algorithms to establish accelerator movements that are programmed directly for IMRT, VMAT and stereotactic treatments. These advances have made commissioning and QA of the TPS much more challenging. This education session reviews up-to-date experience and guidance on this subject; including the recently published AAPM Medical Physics Practice Guideline (MPPG) #5 “Commissioning and QA of Treatment Planning Dose Calculations: Megavoltage Photon and Electron Beams”. Treatment Planning System Commissioning and QA: Challenges and Opportunities (Greg Salomons) This session will provide some key background and review publications describing prominent incidents relating to TPS commissioning and QA. Traditional approaches have been hardware and feature oriented. They aim to establish a functional configuration and establish specifications for regular testing of features (like dose calculation) to assure stable operation and detect failures. With the advent of more complex systems, more patient-specific testing has also been adopted. A number of actual TPS defects will be presented along with heuristics for identifying similar

  8. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Hannan, M.A., E-mail: hannan@eng.ukm.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Abdulla Al Mamun, Md., E-mail: md.abdulla@siswa.ukm.edu.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Hussain, Aini, E-mail: aini@eng.ukm.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Basri, Hassan, E-mail: drhb@ukm.my [Department of Civil and Structural Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Begum, R.A., E-mail: rawshan@ukm.edu.my [Institute of Climate Change, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia)

    2015-09-15

    Highlights: • Classification of available technologies for SWM system in four core category. • Organization of technology based SWM systems in three main groups. • Summary of SWM systems with target application, methodology and functional domain. • Issues and challenges are highlighted for further design of a sustainable system. - Abstract: In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system.

  9. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges

    International Nuclear Information System (INIS)

    Hannan, M.A.; Abdulla Al Mamun, Md.; Hussain, Aini; Basri, Hassan; Begum, R.A.

    2015-01-01

    Highlights: • Classification of available technologies for SWM system in four core category. • Organization of technology based SWM systems in three main groups. • Summary of SWM systems with target application, methodology and functional domain. • Issues and challenges are highlighted for further design of a sustainable system. - Abstract: In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system

  10. Alternative and augmentative communication systems (AACS as an instrument for decreasing challenging behaviour to students with ASD: a case study

    Directory of Open Access Journals (Sweden)

    Rosa Mira Pastor

    2017-06-01

    Full Text Available An intervention based on the Benson Schaeffer’s Speak Signal Program, to provide an eight years old girl with Autism Spectrum Disorder (ASD with the Alternative and Augmentative Communication System (AACS is described. The intervention aims at promoting the use of signs to express her needs and through this achieve a decrease in challenging behaviors, mostly produced when trying to communicate. A qualitative single case study by objective methodology was used. The program was developed in the communication and language classroom of a public school for children in nursery and primary education in Valencia. Eight signs worked functionally in different contexts. Likewise, reduction of challenging behavior was evident.

  11. Robot-assisted pyeloplasty for pelvi-ureteric junction obstruction of lower moiety in partial duplex system: A technical challenge

    Directory of Open Access Journals (Sweden)

    Girdhar S Bora

    2016-01-01

    Full Text Available Management of pelvi-ureteric junction obstruction (PUJO in a duplex system is technically challenging as dissection at the pelvis may jeopardize the vascularity of the normal moiety ureter. Anastomosing the pelvis to the one single ureter will have a risk of future development of stricture which then will risk both the moieties. Robotic assistance enables appropriate tissue dissection; minimal handling of normal ureter and precision in suturing, overcoming the potential challenges involved in the minimally invasive management of such complex cases. We report the feasibility and efficacy of robot-assisted laparoscopic pyeloplasty in such case.

  12. Applying a framework for assessing the health system challenges to scaling up mHealth in South Africa

    Directory of Open Access Journals (Sweden)

    Leon Natalie

    2012-11-01

    Full Text Available Abstract Background Mobile phone technology has demonstrated the potential to improve health service delivery, but there is little guidance to inform decisions about acquiring and implementing mHealth technology at scale in health systems. Using the case of community-based health services (CBS in South Africa, we apply a framework to appraise the opportunities and challenges to effective implementation of mHealth at scale in health systems. Methods A qualitative study reviewed the benefits and challenges of mHealth in community-based services in South Africa, through a combination of key informant interviews, site visits to local projects and document reviews. Using a framework adapted from three approaches to reviewing sustainable information and communication technology (ICT, the lessons from local experience and elsewhere formed the basis of a wider consideration of scale up challenges in South Africa. Results Four key system dimensions were identified and assessed: government stewardship and the organisational, technological and financial systems. In South Africa, the opportunities for successful implementation of mHealth include the high prevalence of mobile phones, a supportive policy environment for eHealth, successful use of mHealth for CBS in a number of projects and a well-developed ICT industry. However there are weaknesses in other key health systems areas such as organisational culture and capacity for using health information for management, and the poor availability and use of ICT in primary health care. The technological challenges include the complexity of ensuring interoperability and integration of information systems and securing privacy of information. Finally, there are the challenges of sustainable financing required for large scale use of mobile phone technology in resource limited settings. Conclusion Against a background of a health system with a weak ICT environment and limited implementation capacity, it remains

  13. Technical Challenges in the Application and Licensing of Digital Instrumentation and Control Systems in Nuclear Power Plants

    International Nuclear Information System (INIS)

    2015-01-01

    With the modernization of existing analogue instrumentation and control (I&C) systems in nuclear power plants through digital I&C technology, and the implementation of digital I&C systems in new plants, the industry is faced with significant challenges. These challenges appear in the form of difficulties in managing the necessarily incremental transition, highly integrated (and interdependent) architectures, the flexible configurability enabled by digital technology, and uncertainty and inconsistency in licensing digital I&C systems and equipment in the different Member States. This publication discusses 17 major issues that utilities, developers, suppliers and regulatory stakeholders need to consider, so that the industry can capture and benefit from shared experience, recent technological developments, and emerging best practices

  14. Challenges in predicting climate and environmental effects on vector-borne disease episystems in a changing world.

    Science.gov (United States)

    Tabachnick, W J

    2010-03-15

    Vector-borne pathogens cause enormous suffering to humans and animals. Many are expanding their range into new areas. Dengue, West Nile and Chikungunya have recently caused substantial human epidemics. Arthropod-borne animal diseases like Bluetongue, Rift Valley fever and African horse sickness pose substantial threats to livestock economies around the world. Climate change can impact the vector-borne disease epidemiology. Changes in climate will influence arthropod vectors, their life cycles and life histories, resulting in changes in both vector and pathogen distribution and changes in the ability of arthropods to transmit pathogens. Climate can affect the way pathogens interact with both the arthropod vector and the human or animal host. Predicting and mitigating the effects of future changes in the environment like climate change on the complex arthropod-pathogen-host epidemiological cycle requires understanding of a variety of complex mechanisms from the molecular to the population level. Although there has been substantial progress on many fronts the challenges to effectively understand and mitigate the impact of potential changes in the environment on vector-borne pathogens are formidable and at an early stage of development. The challenges will be explored using several arthropod-borne pathogen systems as illustration, and potential avenues to meet the challenges will be presented.

  15. Qualitative analysis of round-table discussions on the business case and procurement challenges for hospital electronic prescribing systems.

    Directory of Open Access Journals (Sweden)

    Kathrin M Cresswell

    Full Text Available There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making.We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9.We drew on data from 17 participants (approximately eight per roundtable, six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing "wants" and aspirations from organizational "needs".Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management.

  16. Qualitative analysis of round-table discussions on the business case and procurement challenges for hospital electronic prescribing systems.

    Science.gov (United States)

    Cresswell, Kathrin M; Slee, Ann; Coleman, Jamie; Williams, Robin; Bates, David W; Sheikh, Aziz

    2013-01-01

    There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making. We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9. We drew on data from 17 participants (approximately eight per roundtable), six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing "wants" and aspirations from organizational "needs". Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management.

  17. Combined assessment of attentional reserve and cognitive-motor effort under various levels of challenge with a dry EEG system.

    Science.gov (United States)

    Gentili, Rodolphe J; Jaquess, Kyle J; Shuggi, Isabelle M; Shaw, Emma P; Oh, Hyuk; Lo, Li-Chuan; Tan, Ying Ying; Domingues, Clayton A; Blanco, Justin A; Rietschel, Jeremy C; Miller, Matthew W; Hatfield, Bradley D

    2018-02-09

    A novel ERP approach was proposed to index variations in mental workload, particularly in attentional reserve, which is complementary to EEG spectral content thought to reflect mental effort. To our knowledge, no study has assessed mental effort and attentional reserve simultaneously in EEG gel-based and, importantly, dry systems, which are particularly well suited for real-world settings. Therefore, by systematically considering ERP, EEG spectral, and importantly the combination of both, this study examined if a small set of dry EEG electrodes could detect changes in both spectral and ERP metrics to assess the mental workload under various challenges with a similar fidelity to their gel-based counterparts in a laboratory setting. By employing both EEG gel-based and dry systems, the ERP and spectral markers were computed while participants executed a visuomotor task under three levels of challenge. For both EEG systems, more challenging levels of difficulty were associated with concomitant changes in ERP amplitude, and spectral power reflected a reduction of the attentional reserve and an increase in cognitive-motor effort, respectively. Those variations in attentional reserve and cognitive-motor effort collectively indexed mental workload with nearly identical fidelity for both gel-based and dry EEG systems. These findings promise to assess the mental workload in situations where the use of dry EEG systems could be advantageously employed to examine human cognitive-motor performance. © 2018 Society for Psychophysiological Research.

  18. Computerization of workflows, guidelines, and care pathways: a review of implementation challenges for process-oriented health information systems.

    Science.gov (United States)

    Gooch, Phil; Roudsari, Abdul

    2011-01-01

    There is a need to integrate the various theoretical frameworks and formalisms for modeling clinical guidelines, workflows, and pathways, in order to move beyond providing support for individual clinical decisions and toward the provision of process-oriented, patient-centered, health information systems (HIS). In this review, we analyze the challenges in developing process-oriented HIS that formally model guidelines, workflows, and care pathways. A qualitative meta-synthesis was performed on studies published in English between 1995 and 2010 that addressed the modeling process and reported the exposition of a new methodology, model, system implementation, or system architecture. Thematic analysis, principal component analysis (PCA) and data visualisation techniques were used to identify and cluster the underlying implementation 'challenge' themes. One hundred and eight relevant studies were selected for review. Twenty-five underlying 'challenge' themes were identified. These were clustered into 10 distinct groups, from which a conceptual model of the implementation process was developed. We found that the development of systems supporting individual clinical decisions is evolving toward the implementation of adaptable care pathways on the semantic web, incorporating formal, clinical, and organizational ontologies, and the use of workflow management systems. These architectures now need to be implemented and evaluated on a wider scale within clinical settings.

  19. E-Learning in Supplemental Educational Systems in Taiwan: Present Status and Future Challenges

    Science.gov (United States)

    Zhang, Ke; Hung, Jui-Long

    2009-01-01

    As Taiwan's full-scale e-learning initiatives moved to the seventh year in 2009, the current status and challenges of e-learning development there are yet to be fully understood. Further extending Zhang and Hung's (2006) investigation on e-learning in all universities and colleges in Taiwan, this study investigated the after-school programs (ASPs)…

  20. Towards Achieving a Critical Thinking Society in Malaysia: A Challenge to School Libraries and Educational Systems.

    Science.gov (United States)

    Yaacob, Raja Abdullah; Seman, Norma Abur

    One of the challenges facing Malaysia amidst its economic development is the achievement of a critical thinking society. This would enhance and guarantee the success of research and development programs in addition to having other socioeconomic effects. This paper covers the following topics: Vision 2020, Malaysia's goal to reach developed nation…

  1. Challenges and Prospects of Staff Development Programmes in Nigeria's Secondary School System: An Overview

    Science.gov (United States)

    Asaya, Samuel Adetunji

    2011-01-01

    The vices rampant now among students in Nigeria secondary schools, such as acts of indiscipline, stealing, cheating, truancy, rioting, cultism, and raping, together with population explosion, call for special skills on the part of the school administrators to be able to cope with these challenges. Consequently, this paper examines the uniqueness…

  2. Building and Sustaining Complex Systems: Addressing Common Challenges to Implementing Intensive Intervention

    Science.gov (United States)

    McInerney, Maurice; Zumeta, Rebecca O.; Gandhi, Allison G.; Gersten, Russell

    2014-01-01

    School and district personnel have identified common challenges in implementing individualized, intensive interventions for students with severe, persistent learning and behavioral needs. The National Center on Intensive Intervention has worked with scores of local educators--including district administrators, building principals, special and…

  3. Tool integration and interoperability challenges of a system-level design flow: A case study

    NARCIS (Netherlands)

    Pimentel, A.D.; Stefanov, T.; Nikolov, H.; Thompson, M.; Polstra, S.; Deprettere, E.F.

    2008-01-01

    Daedalus is a system-level design flow for the design of multiprocessor system-on-chip (MP-SoC) based embedded multimedia systems. It offers a fully integrated tool-flow in which design exploration, system-level synthesis, application mapping, and system prototyping of MP-SoC architectures are

  4. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges.

    Science.gov (United States)

    Hannan, M A; Abdulla Al Mamun, Md; Hussain, Aini; Basri, Hassan; Begum, R A

    2015-09-01

    In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Achilles' Head: Understanding the Challenges in Implementing Dependable and Secure Deeply Networked Military Embedded Systems

    National Research Council Canada - National Science Library

    Sarji, David K

    2008-01-01

    ... (IT) systems has made it abundantly clear that computing systems are subject to attacks, and that including security in the design process is a critical component in the development of new systems...

  6. Health system challenges for the management of cardiovascular disease and diabetes: an empirical qualitative study from Syria.

    Science.gov (United States)

    Ahmad, Balsam; Fouad, Fouad M; Elias, Madonna; Zaman, Shahaduz; Phillimore, Peter; Maziak, Wasim

    2015-01-01

    To explore through empirical qualitative data health system barriers to effective management of cardiovascular disease and diabetes in Syria before the crisis, and how such analysis can inform the building of a post-crisis system. Data were collected through document review, semi-structured key informant interviews, and fieldwork in clinics. Institutional commitment to address the increasing burden of CVD and diabetes in Syria was limited and uncoordinated. Challenges included an increasingly split healthcare system, with private provision for those who could afford it, and a residual state health sector for the majority. Public trust in the system had been declining. We conclude that lack of effective management of CVD and diabetes indicated weaknesses of the state and its retracting role in providing effective healthcare. Such weaknesses that existed before the crisis are now compounded by new challenges resulting from wide destruction of the health system due to the ongoing war. The rebuilding of post-conflict heath care system may benefit from insights into the structural problems of the pre-crisis system.

  7. Formidable achievement through determination and pragmatism

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Anglo American Corporation's former chief consulting metallurgist Ewen Pinkney has a remarkable record of achievement in mining metallurgy and chemical engineering at mines all over Southern Africa despite the fact that he could not afford a university education. Just one feature of his career was the leading role he played in the establishment of the country's first big uranium plants. This as well as other features of his career are discussed

  8. Airport baggage handling--where do human factors fit in the challenges that airports put on a baggage system?

    Science.gov (United States)

    Lenior, O N M

    2012-01-01

    The challenges put on large baggage systems by airports can be summarized as: handling a high number of bags in a short period of time, in a limited space, with all sorts of disruptions, whilst complying with stringent regulation upon security, sustainability and health and safety. The aim of this company case study is to show in the different project phases--as indicated in the system ergonomic approach--how the human factors specialist can play a major part in tackling these challenges. By describing different projects in terms of scope, organization, human factors topics covered, phases and lessons learned, the importance of Human-Computer Interaction, automation as well as manual handling and work organization in baggage is addressed.

  9. Sympathetic nervous system activity measured by skin conductance quantifies the challenge of walking adaptability tasks after stroke.

    Science.gov (United States)

    Clark, David J; Chatterjee, Sudeshna A; McGuirk, Theresa E; Porges, Eric C; Fox, Emily J; Balasubramanian, Chitralakshmi K

    2018-02-01

    Walking adaptability tasks are challenging for people with motor impairments. The construct of perceived challenge is typically measured by self-report assessments, which are susceptible to subjective measurement error. The development of an objective physiologically-based measure of challenge may help to improve the ability to assess this important aspect of mobility function. The objective of this study to investigate the use of sympathetic nervous system (SNS) activity measured by skin conductance to gauge the physiological stress response to challenging walking adaptability tasks in people post-stroke. Thirty adults with chronic post-stroke hemiparesis performed a battery of seventeen walking adaptability tasks. SNS activity was measured by skin conductance from the palmar surface of each hand. The primary outcome variable was the percent change in skin conductance level (ΔSCL) between the baseline resting and walking phases of each task. Task difficulty was measured by performance speed and by physical therapist scoring of performance. Walking function and balance confidence were measured by preferred walking speed and the Activities-specific Balance Confidence Scale, respectively. There was a statistically significant negative association between ΔSCL and task performance speed and between ΔSCL and clinical score, indicating that tasks with greater SNS activity had slower performance speed and poorer clinical scores. ΔSCL was significantly greater for low functioning participants versus high functioning participants, particularly during the most challenging walking adaptability tasks. This study supports the use of SNS activity measured by skin conductance as a valuable approach for objectively quantifying the perceived challenge of walking adaptability tasks in people post-stroke. Published by Elsevier B.V.

  10. Development Challenges of Game-Changing Entry System Technologies From Concept to Mission Infusion

    Science.gov (United States)

    Venkatapathy, Ethiraj; Beck, Robin; Ellerby, Don; Feldman, Jay; Gage, Peter; Munk, Michelle; Wercinski, Paul

    2016-01-01

    Realization within the US and NASA that future exploration both Human and Robotic will require innovative new technologies led to the creation of the Space Technology Mission Directorate and investment in game changing technologies with high pay-off. Some of these investments will see success and others, due to many of the constraints, will not attain their goal. The co-authors of this proposed presentation have been involved from concept to mission infusion aspects of entry technologies that are game changing. The four example technologies used to describe the challenges experienced along the pathways to success are at different levels of maturity. They are Conformal, 3-D MAT, HEEET and ADEPT. The four examples in many ways capture broad aspects of the challenges of maturation and illustrate what led some to be exceptionally successful and how others had to be altered in order remain viable game changing technologies.

  11. Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge.

    Science.gov (United States)

    Norden, Diana M; Trojanowski, Paige J; Villanueva, Emmanuel; Navarro, Elisa; Godbout, Jonathan P

    2016-02-01

    Activation of the peripheral immune system elicits a coordinated response from the central nervous system. Key to this immune to brain communication is that glia, microglia, and astrocytes, interpret and propagate inflammatory signals in the brain that influence physiological and behavioral responses. One issue in glial biology is that morphological analysis alone is used to report on glial activation state. Therefore, our objective was to compare behavioral responses after in vivo immune (lipopolysaccharide, LPS) challenge to glial specific mRNA and morphological profiles. Here, LPS challenge induced an immediate but transient sickness response with decreased locomotion and social interaction. Corresponding with active sickness behavior (2-12 h), inflammatory cytokine mRNA expression was elevated in enriched microglia and astrocytes. Although proinflammatory cytokine expression in microglia peaked 2-4 h after LPS, astrocyte cytokine, and chemokine induction was delayed and peaked at 12 h. Morphological alterations in microglia (Iba-1(+)) and astrocytes (GFAP(+)), however, were undetected during this 2-12 h timeframe. Increased Iba-1 immunoreactivity and de-ramified microglia were evident 24 and 48 h after LPS but corresponded to the resolution phase of activation. Morphological alterations in astrocytes were undetected after LPS. Additionally, glial cytokine expression did not correlate with morphology after four repeated LPS injections. In fact, repeated LPS challenge was associated with immune and behavioral tolerance and a less inflammatory microglial profile compared with acute LPS challenge. Overall, induction of glial cytokine expression was sequential, aligned with active sickness behavior, and preceded increased Iba-1 or GFAP immunoreactivity after LPS challenge. © 2015 Wiley Periodicals, Inc.

  12. The impact of civilian control on contemporary defense planning systems challenges for South East Europe

    OpenAIRE

    Molodilo, Diana

    2011-01-01

    Approved for public release; distribution is unlimited. Defense planning has always been one of the most sensitive issues in promoting civilian control of the armed forces. Ensuring democratic control of defense policy is a challenging task, and Southeastern Europe's (SEE) experience to date has inevitably been mixed. At this phase of the reform process, some countries from the region do not possess the necessary civilian knowledge to replace the dominance of the armed forces in the defens...

  13. Challenges with the implementation of an Integrated Disease Surveillance and Response (IDSR) system: systematic review of the lessons learned.

    Science.gov (United States)

    Phalkey, Revati K; Yamamoto, Shelby; Awate, Pradip; Marx, Michael

    2015-02-01

    Despite a realistic strategy and availability of resources, multiple challenges still overwhelm countries grappling with the challenges of communicable disease surveillance. The Integrated Disease Surveillance and Response (IDSR) strategy is by far the most pragmatic strategy in resource-poor settings. The objective of this study was to systematically review and document the lessons learned and the challenges identified with the implementation of the IDSR in low- and middle-income countries and to identify the main barriers that contribute to its sub-optimal functioning. A systematic review of literature published in English using Web of Knowledge, PubMed, and databases of the World Health Organization (WHO) and the Centers for Disease Control (CDC) between 1998 and 2012 was undertaken. Additionally, manual reference and grey literature searches were conducted. Citations describing core and support functions or the quality attributes of the IDSR as described by WHO and CDC were included in the review. Thirty-three assessment studies met the inclusion criteria. IDSR strategy has been best adopted and implemented in the WHO-AFRO region. Although significant progress is made in overcoming the challenges identified with vertical disease surveillance strategies, gaps still exist. Mixed challenges with core and support IDSR functions were observed across countries. Main issues identified include non-sustainable financial resources, lack of co-ordination, inadequate training and turnover of peripheral staff, erratic feedback, inadequate supervision from the next level, weak laboratory capacities coupled with unavailability of job aids (case definitions/reporting formats), and poor availability of communication and transport systems particularly at the periphery. Best outcomes in core functions and system attributes were reported when support surveillance functions performed optimally. Apart from technical and technological issues, human resources and the health care

  14. Challenges in immunisation service delivery for refugees in Australia: A health system perspective.

    Science.gov (United States)

    Mahimbo, A; Seale, H; Smith, M; Heywood, A

    2017-09-12

    Refugees are at risk of being under-immunised in their countries of origin, in transit and post-resettlement in Australia. Whilst studies have focused on identifying barriers to accessibility of health services among refugees, few focus on providers' perspectives on immunisation service delivery to this group. Health service providers are well placed to provide insights into the pragmatic challenges associated with refugee health service delivery, which can be useful in identifying strategies aimed at improving immunisation coverage among this group. A qualitative study involving 30 semi-structured interviews was undertaken with key stakeholders in immunisation service delivery across all States and Territories in Australia between December 2014 and December 2015. Thematic analysis was undertaken. Variability in accessing program funding and vaccines, lack of a national policy for catch-up vaccination, unclear roles and responsibilities for catch-up, a lack of a central immunisation register and insufficient training among general practitioners were seen as the main challenges impacting on immunisation service delivery for refugees. This study provides insight into the challenges that impact on effective immunisation service delivery for refugees. Deliberate strategies such as national funding for relevant vaccines, improved data collection nationally and increased guidance for general practitioners on catch-up immunisation for refugees would help to ensure equitable access across all age groups. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Future Opportunities and Challenges with Using Demand Response as a Resource in Distribution System Operation and Planning Activities

    Energy Technology Data Exchange (ETDEWEB)

    Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); MacDonald, Jason [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Page, Janie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Potter, Jennifer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stewart, Emma [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-01-01

    This scoping study focuses on identifying the ability for current and future demand response opportunities to contribute to distribution system management. To do so, this scoping study will identify the needs of a distribution system to operate efficiently, safely and reliably; summarize both benefits and challenges for the operation of the distribution system with high penetration levels of distributed energy resources; define a suite of services based on those changing operational needs that could be provided by resources; identify existing demand response opportunities sponsored by distribution utilities and/or aggregators of retail customers; assess the extent to which distribution system services can be provided via DR opportunities both in their current form and with alterations to their design; and provide a qualitative assessment of coordination issues that bulk power and distribution system providers of DR opportunities will need to address.

  16. Challenges of Using E-learning Management Systems faced by the ...

    African Journals Online (AJOL)

    OUT) to find out how lecturers use the E-learning Management System (ELMS) and the problems that they encounter when using the ELMS. Based on the general hypothesis of the use of Information Systems, different methodologies were ...

  17. The ProADAPT System in the 2009 Diagnostic Challenge Competition

    Data.gov (United States)

    National Aeronautics and Space Administration — Reliable systems health management is an important research area of NASA. A health management system that can accurately and quickly diagnose faults in various...

  18. FINANCIAL REPORTING AND THE COMPUTERISED ACCOUNTING INFORMATION SYSTEM: BENEFITS AND CHALLENGES

    OpenAIRE

    Aregbesola, Olateju.D; Adeleke, Ezekiel.O,; Olaose, Odunayo O

    2013-01-01

    This paper examined the importance of computerized accounting information system as an effective tool for accurate and reliable financial reporting. An accounting information system is a system of collection, storage and processing of financial and accounting data that is used by decision makers. Furthermore, in the computerized system of accounting, the computer handles every step in the accounting process from recording the financial transaction to preparing the financial statem...

  19. Designing High Quality Evaluation Systems for High School Teachers: Challenges and Potential Solutions

    Science.gov (United States)

    Tyler, John H.

    2011-01-01

    A central part of education reform today is the wide-ranging and unprecedented effort to either revamp existing teacher evaluation systems or develop and implement entirely new systems. High-quality teacher evaluation systems are seen as one lever for improving the teacher workforce and hence the outcomes of students, including high school…

  20. Challenges to Cognitive Systems Engineering:Understanding Qualitative Aspects of Control Actions

    DEFF Research Database (Denmark)

    Lind, Morten

    2009-01-01

    The paper discusses the future role of Cognitive Systems Engineering (CSE) in contributing to integrated design of process, automation and human machine systems. Existing concepts and methods of Cognitive Systems Engineering do not integrate well with control theory and industrial automation tools...