WorldWideScience

Sample records for system formidable challenges

  1. Family Planning in the Democratic Republic of the Congo: Encouraging Momentum, Formidable Challenges

    Science.gov (United States)

    Kwete, Dieudonné; Binanga, Arsene; Mukaba, Thibaut; Nemuandjare, Théophile; Mbadu, Muanda Fidele; Kyungu, Marie-Thérèse; Sutton, Perri; Bertrand, Jane T

    2018-01-01

    Momentum for family planning in the Democratic Republic of the Congo (DRC) is evident in multiple ways: strong political will, increasing donor support, a growing number of implementing organizations, innovative family planning programming, and a cohesive family planning stakeholder group. Between 2013 and 2017, the modern contraceptive prevalence rate (mCPR) in the capital city of Kinshasa increased from 18.5% to 26.7% among married women, but as of 2013–14, it was only 7.8% at the national level. The National Multisectoral Strategic Plan for Family Planning: 2014–2020 calls for achieving an mCPR of 19.0% by 2020, an ambitious goal in light of formidable challenges to family planning in the DRC. Of the 16,465 health facilities reporting to the national health information system in 2017, only 40% offer family planning services. Key challenges include uncertainty over the political situation, difficulties of ensuring access to family planning services in a vast country with a weak transportation infrastructure, funding shortfalls for procuring adequate quantities of contraceptives, weak contraceptive logistics and supply chain management, strong cultural norms that favor large families, and low capacity of the population to pay for contraceptive services. This article describes promising initiatives designed to address these barriers, consistent with the World Health Organization's framework for health systems strengthening. For example, the national family planning coordinating mechanism is being replicated at the provincial level to oversee the expansion of family planning service delivery. Promising initiatives are being implemented to improve the supply and quality of services and generate demand for family planning, including social marketing of subsidized contraceptives at both traditional and non-traditional channels and strengthening of services in military health facilities. To expand contraceptive access, family planning is being institutionalized in

  2. Family Planning in the Democratic Republic of the Congo: Encouraging Momentum, Formidable Challenges.

    Science.gov (United States)

    Kwete, Dieudonné; Binanga, Arsene; Mukaba, Thibaut; Nemuandjare, Théophile; Mbadu, Muanda Fidele; Kyungu, Marie-Thérèse; Sutton, Perri; Bertrand, Jane T

    2018-03-21

    Momentum for family planning in the Democratic Republic of the Congo (DRC) is evident in multiple ways: strong political will, increasing donor support, a growing number of implementing organizations, innovative family planning programming, and a cohesive family planning stakeholder group. Between 2013 and 2017, the modern contraceptive prevalence rate (mCPR) in the capital city of Kinshasa increased from 18.5% to 26.7% among married women, but as of 2013-14, it was only 7.8% at the national level. The National Multisectoral Strategic Plan for Family Planning: 2014-2020 calls for achieving an mCPR of 19.0% by 2020, an ambitious goal in light of formidable challenges to family planning in the DRC. Of the 16,465 health facilities reporting to the national health information system in 2017, only 40% offer family planning services. Key challenges include uncertainty over the political situation, difficulties of ensuring access to family planning services in a vast country with a weak transportation infrastructure, funding shortfalls for procuring adequate quantities of contraceptives, weak contraceptive logistics and supply chain management, strong cultural norms that favor large families, and low capacity of the population to pay for contraceptive services. This article describes promising initiatives designed to address these barriers, consistent with the World Health Organization's framework for health systems strengthening. For example, the national family planning coordinating mechanism is being replicated at the provincial level to oversee the expansion of family planning service delivery. Promising initiatives are being implemented to improve the supply and quality of services and generate demand for family planning, including social marketing of subsidized contraceptives at both traditional and non-traditional channels and strengthening of services in military health facilities. To expand contraceptive access, family planning is being institutionalized in

  3. To Defer or To Stand Up? How Offender Formidability Affects Third Party Moral Outrage

    DEFF Research Database (Denmark)

    Jensen, Niels Holm; Petersen, Michael Bang

    2011-01-01

    . Deciding whether to defer to or stand up against a formidable exploiter is a complicated decision as there is both much to lose (formidable individuals are able and prone to retaliate) and much to gain (formidable individuals pose a great future threat). An optimally designed outrage system should...

  4. Maoecrystal V: A formidable synthetic challenge

    Indian Academy of Sciences (India)

    Maoecrystal V; synthesis; Diels–Alder reaction; dearomatization. 1. Introduction. There is continuing search for ... of ailments, is known to be a rich source of biologi- cally active diterpenoids.5 Maoecrystal V (figure 1) ... ever, only two groups have succeeded in the synthesis of maoecrystal V since its isolation a decade ago.

  5. Weapons make the man (larger: formidability is represented as size and strength in humans.

    Directory of Open Access Journals (Sweden)

    Daniel M T Fessler

    Full Text Available In order to determine how to act in situations of potential agonistic conflict, individuals must assess multiple features of a prospective foe that contribute to the foe's resource-holding potential, or formidability. Across diverse species, physical size and strength are key determinants of formidability, and the same is often true for humans. However, in many species, formidability is also influenced by other factors, such as sex, coalitional size, and, in humans, access to weaponry. Decision-making involving assessments of multiple features is enhanced by the use of a single summary variable that encapsulates the contributions of these features. Given both a the phylogenetic antiquity of the importance of size and strength as determinants of formidability, and b redundant experiences during development that underscore the contributions of size and strength to formidability, we hypothesize that size and strength constitute the conceptual dimensions of a representation used to summarize multiple diverse determinants of a prospective foe's formidability. Here, we test this hypothesis in humans by examining the effects of a potential foe's access to weaponry on estimations of that individual's size and strength. We demonstrate that knowing that an individual possesses a gun or a large kitchen knife leads observers to conceptualize him as taller, and generally larger and more muscular, than individuals who possess only tools or similarly mundane objects. We also document that such patterns are not explicable in terms of any actual correlation between gun ownership and physical size, nor can they be explained in terms of cultural schemas or other background knowledge linking particular objects to individuals of particular size and strength. These findings pave the way for a fuller understanding of the evolution of the cognitive systems whereby humans--and likely many other social vertebrates--navigate social hierarchies.

  6. Airway management in Escobar syndrome: A formidable challenge

    Directory of Open Access Journals (Sweden)

    Shaji Mathew

    2013-01-01

    Full Text Available Escobar syndrome is a rare autosomal recessive disorder characterized by flexion joint and digit contractures, skin webbing, cleft palate, deformity of spine and cervical spine fusion. Associated difficult airway is mainly due to micrognathia, retrognathia, webbing of neck and limitation of the mouth opening and neck extension. We report a case of a 1 year old child with Escobar syndrome posted for bilateral hamstrings to quadriceps transfer. The child had adequate mouth opening with no evidence of cervical spine fusion, yet we faced difficulty in intubation which was ultimately overcome by securing a proseal laryngeal mask airway (PLMA and then by intubating with an endotracheal tube railroaded over a paediatric fibreoptic bronchoscope passed through the lumen of a PLMA.

  7. Oral rehabilitation of the cancer patient: A formidable challenge.

    Science.gov (United States)

    Petrovic, Ivana; Rosen, Evan B; Matros, Evan; Huryn, Joseph M; Shah, Jatin P

    2018-05-03

    Rehabilitation of oral functions following surgery on the jaws is a goal that is often difficult to achieve. Removable dentures supported by remaining teeth or gum are often unstable and seldom satisfactory. On the other hand, endosseous (dental) implants offer a mechanism to provide stability to the dentures. This review, discusses factors related to the tumor, patient, treatment, and physicians which impact upon the feasibility and success of dental implants in patients with oral cancer. © 2018 Wiley Periodicals, Inc.

  8. The role of physical formidability in human social status allocation.

    Science.gov (United States)

    Lukaszewski, Aaron W; Simmons, Zachary L; Anderson, Cameron; Roney, James R

    2016-03-01

    Why are physically formidable men willingly allocated higher social status by others in cooperative groups? Ancestrally, physically formidable males would have been differentially equipped to generate benefits for groups by providing leadership services of within-group enforcement (e.g., implementing punishment of free riders) and between-group representation (e.g., negotiating with other coalitions). Therefore, we hypothesize that adaptations for social status allocation are designed to interpret men's physical formidability as a cue to these leadership abilities, and to allocate greater status to formidable men on this basis. These hypotheses were supported in 4 empirical studies wherein young adults rated standardized photos of subjects (targets) who were described as being part of a white-collar business consultancy. In Studies 1 and 2, male targets' physical strength positively predicted ratings of their projected status within the organization, and this effect was mediated by perceptions that stronger men possessed greater leadership abilities of within-group enforcement and between-group representation. Moreover, (a) these same patterns held whether status was conceptualized as overall ascendancy, prestige-based status, or dominance-based status, and (b) strong men who were perceived as aggressively self-interested were not allocated greater status. Finally, 2 experiments established the causality of physical formidability's effects on status-related perceptions by manipulating targets' relative strength (Study 3) and height (Study 4). In interpreting our findings, we argue that adaptations for formidability-based status allocation may have facilitated the evolution of group cooperation in humans and other primates. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  9. Systems Challenges for Hypersonic Vehicles

    Science.gov (United States)

    Hunt, James L.; Laruelle, Gerard; Wagner, Alain

    1997-01-01

    This paper examines the system challenges posed by fully reusable hypersonic cruise airplanes and access to space vehicles. Hydrocarbon and hydrogen fueled airplanes are considered with cruise speeds of Mach 5 and 10, respectively. The access to space matrix is examined. Airbreathing and rocket powered, single- and two-stage vehicles are considered. Reference vehicle architectures are presented. Major systems/subsystems challenges are described. Advanced, enhancing systems concepts as well as common system technologies are discussed.

  10. Grand Challenges facing Storage Systems

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    In this talk, we will discuss the future of storage systems. In particular, we will focus on several big challenges which we are facing in storage, such as being able to build, manage and backup really massive storage systems, being able to find information of interest, being able to do long-term archival of data, and so on. We also present ideas and research being done to address these challenges, and provide a perspective on how we expect these challenges to be resolved as we go forward.

  11. Ecological Challenges for Closed Systems

    Science.gov (United States)

    Nelson, Mark; Dempster, William; Allen, John P.

    2012-07-01

    Closed ecological systems are desirable for a number of purposes. In space life support systems, material closure allows precious life-supporting resources to be kept inside and recycled. Closure in small biospheric systems facilitates detailed measurement of global ecological processes and biogeochemical cycles. Closed testbeds facilitate research topics which require isolation from the outside (e.g. genetically modified organisms; radioisotopes) so their ecological interactions and fluxes can be studied separate from interactions with the outside environment. But to achieve and maintain closure entails solving complex ecological challenges. These challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro- and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet and recycling nutrients and maintaining soil fertility, the sustaining of healthy air and water and preventing the loss of crucial elements from active circulation. In biospheric facilities the challenge is also to produce analogues to natural biomes and ecosystems, studying processes of self-organization and adaptation in systems that allow specification or determination of state variables and cycles which may be followed through all interactions from atmosphere to soils. Other challenges include the dynamics and genetics of small populations, the psychological challenges for small isolated human groups and measures and options which may be necessary to ensure long-term operation of closed ecological systems.

  12. Challenges in parameter identification of large structural dynamic systems

    International Nuclear Information System (INIS)

    Koh, C.G.

    2001-01-01

    In theory, it is possible to determine the parameters of a structural or mechanical system by subjecting it to some dynamic excitation and measuring the response. Considerable research has been carried out in this subject area known as the system identification over the past two decades. Nevertheless, the challenges associated with numerical convergence are still formidable when the system is large in terms of the number of degrees of freedom and number of unknowns. While many methods work for small systems, the convergence becomes difficult, if not impossible, for large systems. In this keynote lecture, both classical and non-classical system identification methods for dynamic testing and vibration-based inspection are discussed. For classical methods, the extended Kalman filter (EKF) approach is used. On this basis, a substructural identification method has been developed as a strategy to deal with large structural systems. This is achieved by reducing the problem size, thereby significantly improving the numerical convergence and efficiency. Two versions of this method are presented each with its own merits. A numerical example of frame structure with 20 unknown parameters is illustrated. For non-classical methods, the Genetic Algorithm (GA) is shown to be applicable with relative ease due to its 'forward analysis' nature. The computational time is, however, still enormous for large structural systems due to the combinatorial explosion problem. A model GA method has been developed to address this problem and tested with considerable success on a relatively large system of 50 degrees of freedom, accounting for input and output noise effects. An advantages of this GA-based identification method is that the objective function can be defined in response measured. Numerical studies show that the method is relatively robust, as it does in response measured. Numerical studies show that the method is relatively robust, as it dos not require good initial guess and the

  13. Challenges in Designing Mechatronic Systems

    DEFF Research Database (Denmark)

    Torry-Smith, Jonas; Qamar, Ahsan; Achiche, Sofiane

    2013-01-01

    Development of mechatronic products is traditionally carried out by several design experts from different design domains. Performing development of mechatronic products is thus greatly challenging. In order to tackle this, the critical challenges in mechatronics have to be well understood and well...... supported through applicable methods and tools. This paper aims at identifying the major challenges, by conducting a systematic and thorough survey of the most relevant research work in mechatronic design. Solutions proposed in literature are assessed and illustrated through a case study in order...... to investigate if the challenges can be handled appropriately by the methods, tools, and mindsets suggested by the mechatronic community. Using a real world mechatronics case, the paper identifies the areas where further research is required, by showing a clear connection between the actual problems faced during...

  14. Size, skills, and suffrage: Motivated distortions in perceived formidability of political leaders.

    Directory of Open Access Journals (Sweden)

    Jill E P Knapen

    Full Text Available Research shows that perception of physical size and status are positively associated. The current study was developed to replicate and extend earlier research on height perceptions of political leaders, indicating that supporters perceive their leaders as taller than non-supporters do, and winners are perceived as taller after the elections, while losers are perceived as shorter after the elections (winner/loser effects. Individuals use greater height and strength as indications of greater physical formidability. We hypothesized that in-group leaders' height and strength, but not weight, would be overestimated more compared to out-group leaders', and that this status-size association is not only driven by dominance, but also by prestige. We also tested whether previously found gender effects in estimates were due to using one's own height as an anchor, and we used an improved methodological approach by relying on multiple measurements of physical formidability and a within-subject design for testing winner/loser effects. The results of a two-part longitudinal study (self-selected sample via voting advice website; NWave1 = 2,011; NWave2 = 322 suggest that estimated physical formidability of political leaders is affected by motivated perception, as prestige was positively associated with estimated formidability, and in-group leaders were estimated more formidable than out-group leaders. We conclude that distortions in judged formidability related to social status are the result of motivated social perception in order to promote group functioning and leadership. Although we did not replicate a winner-effect (greater estimations of formidability after winning the elections, we did find some evidence for a loser-effect. Earlier suggestions that men make larger estimations than women because of their own larger body size are not supported. Implications for theory and future research are discussed.

  15. Staphylococcus aureus bacteraemia in children: a formidable foe

    African Journals Online (AJOL)

    Staphylococcus aureus bacteraemia is a systemic disease; and, multiple organ involvement should be .... damage.3. Few studies have investigated the epidemiology of SAB in South ... producing a multitude of virulence factors, exotoxins and.

  16. Embedded Systems Design: Optimization Challenges

    DEFF Research Database (Denmark)

    Pop, Paul

    2005-01-01

    Summary form only given. Embedded systems are everywhere: from alarm clocks to PDAs, from mobile phones to cars, almost all the devices we use are controlled by embedded systems. Over 99% of the microprocessors produced today are used in embedded systems, and recently the number of embedded systems...

  17. With God on our side: Religious primes reduce the envisioned physical formidability of a menacing adversary.

    Science.gov (United States)

    Holbrook, Colin; Fessler, Daniel M T; Pollack, Jeremy

    2016-01-01

    The imagined support of benevolent supernatural agents attenuates anxiety and risk perception. Here, we extend these findings to judgments of the threat posed by a potentially violent adversary. Conceptual representations of bodily size and strength summarize factors that determine the relative threat posed by foes. The proximity of allies moderates the envisioned physical formidability of adversaries, suggesting that cues of access to supernatural allies will reduce the envisioned physical formidability of a threatening target. Across two studies, subtle cues of both supernatural and earthly social support reduced the envisioned physical formidability of a violent criminal. These manipulations had no effect on the perceived likelihood of encountering non-conflictual physical danger, raising the possibility that imagined supernatural support leads participants to view themselves not as shielded from encountering perilous situations, but as protected should perils arise. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Assessing Causal Pathways between Physical Formidability and Aggression in Human Males

    DEFF Research Database (Denmark)

    Petersen, Michael Bang; Dawes, Christopher T.

    2017-01-01

    Studies suggest the existence of an association between the physical formidability of human males and their level of aggression. This association is theoretically predictable from animal models of conflict behavior but could emerge from multiple different causal pathways. Previous studies have...... not been able to tease apart these paths, as they have almost exclusively relied on bivariate correlations and cross-sectional data. Here, we apply longitudinal twin data from two different samples to (1) estimate the direction of causality between formidability and aggression by means of quasi......-experimental methods and (2) estimate the relative contribution of genetic and environmental factors by means of twin modeling. Importantly, the results suggest, on the one hand, that the association between formidability and aggression is less reliable than previously thought. On the other hand, the results also...

  19. Challenges for Nordic VET-systems

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    2015-01-01

    , this challenge is not new. It has been on the agenda since the late 1960s following the crisis for apprenticeship and the growing demand for equal access to all levels of education. What is new, however, is that the challenge has intensified and the solutions developed since the 1970s don’t appear tenable today......The systems of vocational education and training (VET) in the Nordic Countries all face a similar challenge: to offer double qualifications. The Nordic VET-systems are expected to give access not only to skilled employment, but also to higher education. As an increasing share of young people....... This situation calls for new solutions to tackle the challenge of double qualifications. The question, which I will examine in this chapter, is how the Nordic VET-systems have handled this challenge in different ways and what these systems can learn from Switzerland, which is often highlighted as a model...

  20. Software challenges in extreme scale systems

    International Nuclear Information System (INIS)

    Sarkar, Vivek; Harrod, William; Snavely, Allan E

    2009-01-01

    Computer systems anticipated in the 2015 - 2020 timeframe are referred to as Extreme Scale because they will be built using massive multi-core processors with 100's of cores per chip. The largest capability Extreme Scale system is expected to deliver Exascale performance of the order of 10 18 operations per second. These systems pose new critical challenges for software in the areas of concurrency, energy efficiency and resiliency. In this paper, we discuss the implications of the concurrency and energy efficiency challenges on future software for Extreme Scale Systems. From an application viewpoint, the concurrency and energy challenges boil down to the ability to express and manage parallelism and locality by exploring a range of strong scaling and new-era weak scaling techniques. For expressing parallelism and locality, the key challenges are the ability to expose all of the intrinsic parallelism and locality in a programming model, while ensuring that this expression of parallelism and locality is portable across a range of systems. For managing parallelism and locality, the OS-related challenges include parallel scalability, spatial partitioning of OS and application functionality, direct hardware access for inter-processor communication, and asynchronous rather than interrupt-driven events, which are accompanied by runtime system challenges for scheduling, synchronization, memory management, communication, performance monitoring, and power management. We conclude by discussing the importance of software-hardware co-design in addressing the fundamental challenges for application enablement on Extreme Scale systems.

  1. Middleware Challenges for Cyber-Physical Systems

    DEFF Research Database (Denmark)

    Mohamed, Nader; Al-Jaroodi, Jameela; Lazarova-Molnar, Sanja

    2017-01-01

    enhancements for improving physical processes, the development of such complex systems composed of many distributed and heterogeneous components is extremely difficult. This is due to the many communication, computing, and networking challenges. Using an appropriate middleware that provides a framework...

  2. Providing Equal Access to Education--A Formidable Challenge for China

    Science.gov (United States)

    Jones, Narelle; Maxwell, Bev; Palmer, Bill

    1996-01-01

    The People's Republic of China has seen a dramatic growth in its economy in recent years. It has a rapidly increasing population of approximately 1.2 billion people, though the population is still largely rural with about 80% of people living outside urban areas. China in its Education Law (1995) restated its commitment to universal education. In…

  3. Key ecological challenges for closed systems facilities

    Science.gov (United States)

    Nelson, Mark; Dempster, William F.; Allen, John P.

    2013-07-01

    Closed ecological systems are desirable for a number of purposes. In space life support systems, material closure allows precious life-supporting resources to be kept inside and recycled. Closure in small biospheric systems facilitates detailed measurement of global ecological processes and biogeochemical cycles. Closed testbeds facilitate research topics which require isolation from the outside (e.g. genetically modified organisms; radioisotopes) so their ecological interactions and fluxes can be studied separate from interactions with the outside environment. But to achieve and maintain closure entails solving complex ecological challenges. These challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro- and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet, recycling nutrients and maintaining soil fertility, the maintenance of healthy air and water and preventing the loss of critical elements from active circulation. In biospheric facilities, the challenge is also to produce analogues to natural biomes and ecosystems, studying processes of self-organization and adaptation in systems that allow specification or determination of state variables and cycles which may be followed through all interactions from atmosphere to soils. Other challenges include the dynamics and genetics of small populations, the psychological challenges for small isolated human groups and backup technologies and strategic options which may be necessary to ensure long-term operation of closed ecological systems.

  4. THE QATAR HEALTH SYSTEM: CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Shaher ALSHAMARI

    2017-06-01

    Full Text Available Qatar’s healthcare system is comparatively new and has experienced noteworthy developments over its brief history. In this paper, our aim is to look at the unique challenges this small nation has faced in building that system. This paper will describe the accomplishments of Qatar’s medical authorities and the challenges they faced. It will also compare public and private healthcare providers. Today, the government of Qatar has financed all the health care for this rapidly-developing, multicultural nation, but it is now planning to introduce medical insurance. This report of its experience will benefit other nations wanting to develop their own healthcare systems.

  5. Applying Systems Engineering on Energy Challenges

    NARCIS (Netherlands)

    Safi, J.; Muller, G.; Bonnema, Gerrit Maarten

    2012-01-01

    Systems engineering is a discipline with methods and techniques to address complex problems. We want to study how Systems Engineering methods can help to address today's grand challenges, such as the energy problem. The first step is problem definition which aims at articulating the problem in its

  6. Control challenges in domestic heating systems

    DEFF Research Database (Denmark)

    Thybo, Honglian; Larsen, Lars F. S.; Weitzmann, Peter

    2007-01-01

    The objective of this paper is to analyze domestic heating applications and identify unfavorable building constructions and control challenges to be addressed by high performance heating control systems. Heating of domestic houses use a large amount of the total energy consumption in Scandinavia....... Hence the potential of reducing energy consumption by applying high performance control is vast. Indoor climate issues are becoming more in focus, which also leads to a demand for high performance heating systems. The paper presents an analysis of how the building elements of today's domestic houses...... with water based floor heating affect the control challenge. The analysis is documented with simulation results....

  7. BPI Challenge 2012 : the transition system case

    NARCIS (Netherlands)

    Verbeek, H.M.W.; La Rosa, M.; Soffer, P.

    2013-01-01

    Using the Transition System Miner as available in ProM6, we have investigated the control-flow perspective, the data perspective, and the resource perspective of the process that underlies the event log provided for the BPI Challenge 2012.

  8. Challenges and progress in turbomachinery design systems

    International Nuclear Information System (INIS)

    Van den Braembussche, R A

    2013-01-01

    This paper first describes the requirements that a modern design system should meet, followed by a comparison between design systems based on inverse design or optimization techniques. The second part of the paper presents the way these challenges are realized in an optimization method combining an Evolutionary theory and a Metamodel. Extensions to multi-disciplinary, multi-point and multi-objective optimization are illustrated by examples

  9. Requirements for guidelines systems: implementation challenges and lessons from existing software-engineering efforts.

    Science.gov (United States)

    Shah, Hemant; Allard, Raymond D; Enberg, Robert; Krishnan, Ganesh; Williams, Patricia; Nadkarni, Prakash M

    2012-03-09

    A large body of work in the clinical guidelines field has identified requirements for guideline systems, but there are formidable challenges in translating such requirements into production-quality systems that can be used in routine patient care. Detailed analysis of requirements from an implementation perspective can be useful in helping define sub-requirements to the point where they are implementable. Further, additional requirements emerge as a result of such analysis. During such an analysis, study of examples of existing, software-engineering efforts in non-biomedical fields can provide useful signposts to the implementer of a clinical guideline system. In addition to requirements described by guideline-system authors, comparative reviews of such systems, and publications discussing information needs for guideline systems and clinical decision support systems in general, we have incorporated additional requirements related to production-system robustness and functionality from publications in the business workflow domain, in addition to drawing on our own experience in the development of the Proteus guideline system (http://proteme.org). The sub-requirements are discussed by conveniently grouping them into the categories used by the review of Isern and Moreno 2008. We cite previous work under each category and then provide sub-requirements under each category, and provide example of similar work in software-engineering efforts that have addressed a similar problem in a non-biomedical context. When analyzing requirements from the implementation viewpoint, knowledge of successes and failures in related software-engineering efforts can guide implementers in the choice of effective design and development strategies.

  10. Multi-scale biomedical systems: measurement challenges

    International Nuclear Information System (INIS)

    Summers, R

    2016-01-01

    Multi-scale biomedical systems are those that represent interactions in materials, sensors, and systems from a holistic perspective. It is possible to view such multi-scale activity using measurement of spatial scale or time scale, though in this paper only the former is considered. The biomedical application paradigm comprises interactions that range from quantum biological phenomena at scales of 10-12 for one individual to epidemiological studies of disease spread in populations that in a pandemic lead to measurement at a scale of 10+7. It is clear that there are measurement challenges at either end of this spatial scale, but those challenges that relate to the use of new technologies that deal with big data and health service delivery at the point of care are also considered. The measurement challenges lead to the use, in many cases, of model-based measurement and the adoption of virtual engineering. It is these measurement challenges that will be uncovered in this paper. (paper)

  11. Challenging problems and solutions in intelligent systems

    CERN Document Server

    Grzegorzewski, Przemysław; Kacprzyk, Janusz; Owsiński, Jan; Penczek, Wojciech; Zadrożny, Sławomir

    2016-01-01

    This volume presents recent research, challenging problems and solutions in Intelligent Systems– covering the following disciplines: artificial and computational intelligence, fuzzy logic and other non-classic logics, intelligent database systems, information retrieval, information fusion, intelligent search (engines), data mining, cluster analysis, unsupervised learning, machine learning, intelligent data analysis, (group) decision support systems, intelligent agents and multi-agent systems, knowledge-based systems, imprecision and uncertainty handling, electronic commerce, distributed systems, etc. The book defines a common ground for sometimes seemingly disparate problems and addresses them by using the paradigm of broadly perceived intelligent systems. It presents a broad panorama of a multitude of theoretical and practical problems which have been successfully dealt with using the paradigm of intelligent computing.

  12. Governance Challenges in Telecoupled Food Systems

    Science.gov (United States)

    Eakin, H.; Mahanti, A.; Rueda, X.

    2015-12-01

    Distal connections increasingly influence food systems' governance: social actors in one geographic context produce intended and unintended consequences in distant locations, coupling the dynamics of socio-ecological systems. While these linkages are not new, economic globalization, urbanization and the dynamics of consumer preferences have accentuated these 'telecoupled' relationships in food systems. Telecoupling refers to the unexpected causal interactions among human-environment systems that were otherwise not linked. This paper presents a framework for evaluating telecoupling processes and outcomes in food systems, focusing on how the disparate scales of drivers and outcomes, diverse values of actors involved, and spatial and social distance combine to challenge socio-ecological system governance. We draw from two examples of food systems (coffee and maize) to argue that telecoupling, as a challenge for food systems, emerges when the institutions and mechanisms of governance acting over one system do not account for the consequences and interactions involving a different system. Telecoupling can stimulate new forms of governance, such as the development of codes of conduct and certification schemes, with positive impacts on food and livelihood security. Our cases suggest that the emergence of new governance arrangements is at least partially contingent on the prior existence of alternative social networks, which cultivate shared values, meanings and goals in food systems, as well as the capacity of affected actors to mobilize political influence and demonstrate plausible causal links. In the absence of such networks and associated capacities, the prior governance arrangements, although poorly adjusted to the new circumstances, are likely to persist, reinforcing existing power relations and the probability of undesirable social and ecological outcomes.

  13. Systems biology solutions for biochemical production challenges

    DEFF Research Database (Denmark)

    Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus

    2017-01-01

    There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics...... characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity...... compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains...

  14. Systems biology solutions for biochemical production challenges.

    Science.gov (United States)

    Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus; Herrgård, Markus J

    2017-06-01

    There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Nuclear Hybrid Energy Systems: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    P. Sabharwall; S.B. Sitton; S.J. Yoon; C. Stoots

    2014-07-01

    With growing demand of energy and costs of the fossil fuels, coupled with the environmental concerns have resulted in an increased interest in alternative energy sources. Nuclear hybrid energy systems (NHES) are being considered which incorporates renewable energy sources such as solar and wind energy combined with nuclear reactor and energy storage to meet the peak hours demand imposed on the grid, along with providing process heat for other potential industrial applications. This concept could potentially satisfy various energy demands and improve reliability, robustness and resilience for the entire system as a whole, along with economic and net efficiency gains. This paper provides a brief understanding of potential NHES system and architecture along with the challenges

  16. Dairy goat production systems: status quo, perspectives and challenges.

    Science.gov (United States)

    Escareño, Luis; Salinas-Gonzalez, Homero; Wurzinger, Maria; Iñiguez, Luiz; Sölkner, Johann; Meza-Herrera, Cesar

    2013-01-01

    Goat production concentrated in developing countries (tropics, dry areas), contributes largely to the livelihoods of low and medium income farmers. Farming systems in these areas have evolved to cope with the formidable constraints imposed by harsh natural and economic conditions by adapting integrated crop/livestock production strategies. In Asia, Africa and Latin America, due to its almost exclusive extensive nature, goat production relies mainly on grazing on communal lands that hardly provide the minimum nutrient requirements due to overstocking and degradation. While some of these production systems are becoming semi-intensive, appropriate breeding strategies should be designed to promote conservation and improvement of their unique attributes, such as adaptability, water use efficiency and suitability under harsh climatic conditions. In Europe, dairy goat production is more common around the Mediterranean basin, where it is important from an economic, environmental and sociological perspective to the Mediterranean countries: Spain, France, Italy and Greece. Europe owns only 5.1 % of the world's dairy goat herds, but produces 15.6 % of the world's goat milk; this is the only continent where goat milk has such an economic importance and organization. In developing countries the dairy goat sector requires a systemic approach, whereby nutrition, animal health, breeding, know-how, inputs and technologies must be assembled. This would allow the optimization of natural and local resources and would promote the transition from a risk reduction strategy towards an increased productivity strategy. Such an increase would privilege production efficiency based on clean, green and ethical practices for responsible innovation.

  17. Information systems in logistics - transition challenges

    Directory of Open Access Journals (Sweden)

    Nikolay Dragomirov

    2016-03-01

    Full Text Available The implementation of information systems in business organizations does not consist of just buying software products and installing them on the servers. Most of these systems are important for the development of the organizations concerned and in some cases are very expensive. Therefore, their success requires a properly managed process of implementation, which seeks a balance between the aims of the systems and the financial and technical capabilities of the organization. The implementation problem becomes greater when the emphasis is on the logistics function in the context of the supply chain management. Last, but not least, these initiatives are related to something much more challenging, namely the adoption of the new information system by the users, which involves a change of habits in the organization. It is no secret that a new system may be rejected by its users and this will make it useless. All this requires finding adequate solutions to analyze these problems and to ensure the effective use of information systems in logistics.

  18. Challenges for Rule Systems on the Web

    Science.gov (United States)

    Hu, Yuh-Jong; Yeh, Ching-Long; Laun, Wolfgang

    The RuleML Challenge started in 2007 with the objective of inspiring the issues of implementation for management, integration, interoperation and interchange of rules in an open distributed environment, such as the Web. Rules are usually classified as three types: deductive rules, normative rules, and reactive rules. The reactive rules are further classified as ECA rules and production rules. The study of combination rule and ontology is traced back to an earlier active rule system for relational and object-oriented (OO) databases. Recently, this issue has become one of the most important research problems in the Semantic Web. Once we consider a computer executable policy as a declarative set of rules and ontologies that guides the behavior of entities within a system, we have a flexible way to implement real world policies without rewriting the computer code, as we did before. Fortunately, we have de facto rule markup languages, such as RuleML or RIF to achieve the portability and interchange of rules for different rule systems. Otherwise, executing real-life rule-based applications on the Web is almost impossible. Several commercial or open source rule engines are available for the rule-based applications. However, we still need a standard rule language and benchmark for not only to compare the rule systems but also to measure the progress in the field. Finally, a number of real-life rule-based use cases will be investigated to demonstrate the applicability of current rule systems on the Web.

  19. Structural materials challenges for fusion power systems

    International Nuclear Information System (INIS)

    Kurtz, Richard J.

    2009-01-01

    Full text: Structural materials in a fusion power system must function in an extraordinarily demanding environment that includes various combinations of high temperatures, reactive chemicals, time-dependent thermal and mechanical stresses, and intense damaging radiation. The fusion neutron environment produces displacement damage equivalent to displacing every atom in the material about 150 times during its expected service life, and changes in chemical composition by transmutation reactions, which includes creation of reactive and insoluble gases. Fundamental materials challenges that must be resolved to effectively harness fusion power include (1) understanding the relationships between material strength, ductility and resistance to cracking, (2) development of materials with extraordinary phase stability, high-temperature strength and resistance to radiation damage, (3) establishment of the means to control corrosion of materials exposed to aggressive environments, (4) development of technologies for large-scale fabrication and joining, and (5) design of structural materials that provide for an economically attractive fusion power system while simultaneously achieving safety and environmental acceptability goals. The most effective approach to solve these challenges is a science-based effort that couples development of physics-based, predictive models of materials behavior with key experiments to validate the models. The U.S. Fusion Materials Sciences program is engaged in an integrated effort of theory, modeling and experiments to develop structural materials that will enable fusion to reach its safety, environmental and economic competitiveness goals. In this presentation, an overview of recent progress on reduced activation ferritic/martensitic steels, nanocomposited ferritic alloys, and silicon carbide fiber reinforced composites for fusion applications will be given

  20. The challenge of greening energy systems

    International Nuclear Information System (INIS)

    Joseph, A.; Hughes, L.

    2006-01-01

    The current state of world energy supply and demand was examined along with future challenges facing population growth, economic growth, energy-demand growth, fossil energy supply, technology improvements, renewable energy solutions, and conservation measures. It was suggested that in order to implement cleaner and greener energy technology, it is important to understand the nature of global energy systems. The challenge of defining the related ideologies of green energy and sustainability was discussed. In this paper, green energy was defined as indicating environmental compatibility with little or no negative environmental impact. This differs from the concept of sustainability, which was defined as an action that can be repeated continuously without depleting or diminishing resources. In general, green energy options include most technologies that do not involve fossil fuels. However, this paper considered a spectrum of shades of green with some options being low-impact and cleaner, and others having high environmental impacts. As an example, the authors presented the ongoing debate over nuclear energy and hydro power. Although both energy sources can be sustainable over hundreds of years, they may or may not be environmentally compatible because they are often considered to have problematic attributes. Energy from renewable sources currently accounts for less than 20 per cent of world primary energy supply because price and implementation challenges in the renewables sector do not generally compare well to other energy sources. With high energy-demands beginning to strain finite fossil-energy supplies, the energy sector is now subject to more frequent disruptions and price fluctuations. Future growth from emerging economies will demand more energy and resources. This paper also emphasized that the proportion of green sources of energy has not increased substantially in the past 3 decades, and despite many technological advances, there continue to be significant

  1. The challenge of greening energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Joseph, A.; Hughes, L. [Dalhousie Univ., Halifax, NS (Canada). Dept. of Electrical and Computer Engineering, Energy Research Group

    2006-07-01

    The current state of world energy supply and demand was examined along with future challenges facing population growth, economic growth, energy-demand growth, fossil energy supply, technology improvements, renewable energy solutions, and conservation measures. It was suggested that in order to implement cleaner and greener energy technology, it is important to understand the nature of global energy systems. The challenge of defining the related ideologies of green energy and sustainability was discussed. In this paper, green energy was defined as indicating environmental compatibility with little or no negative environmental impact. This differs from the concept of sustainability, which was defined as an action that can be repeated continuously without depleting or diminishing resources. In general, green energy options include most technologies that do not involve fossil fuels. However, this paper considered a spectrum of shades of green with some options being low-impact and cleaner, and others having high environmental impacts. As an example, the authors presented the ongoing debate over nuclear energy and hydro power. Although both energy sources can be sustainable over hundreds of years, they may or may not be environmentally compatible because they are often considered to have problematic attributes. Energy from renewable sources currently accounts for less than 20 per cent of world primary energy supply because price and implementation challenges in the renewables sector do not generally compare well to other energy sources. With high energy-demands beginning to strain finite fossil-energy supplies, the energy sector is now subject to more frequent disruptions and price fluctuations. Future growth from emerging economies will demand more energy and resources. This paper also emphasized that the proportion of green sources of energy has not increased substantially in the past 3 decades, and despite many technological advances, there continue to be significant

  2. 78 FR 59974 - Centennial Challenges 2014 Unmanned Aircraft Systems (UAS) Airspace Operations Challenge (AOC)

    Science.gov (United States)

    2013-09-30

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Centennial Challenges 2014 Unmanned Aircraft Systems... wish to compete may now register. Centennial Challenges is a program of prize competitions to stimulate...: http://www.uasaoc.org For general information on the NASA Centennial Challenges Program please visit...

  3. Neural System Prediction and Identification Challenge

    Directory of Open Access Journals (Sweden)

    Ioannis eVlachos

    2013-12-01

    Full Text Available Can we infer the function of a biological neural network (BNN if we know the connectivity and activity of all its constituent neurons? This question is at the core of neuroscience and, accordingly, various methods have been developed to record the activity and connectivity of as many neurons as possible. Surprisingly, there is no theoretical or computational demonstration that neuronal activity and connectivity are indeed sufficient to infer the function of a BNN. Therefore, we pose the Neural Systems Identification and Prediction Challenge (nuSPIC. We provide the connectivity and activity of all neurons and invite participants (i to infer the functions implemented (hard-wired in spiking neural networks (SNNs by stimulating and recording the activity of neurons and, (ii to implement predefined mathematical/biological functions using SNNs. The nuSPICs can be accessed via a web-interface to the NEST simulator and the user is not required to know any specific programming language. Furthermore, the nuSPICs can be used as a teaching tool. Finally, nuSPICs use the crowd-sourcing model to address scientific issues. With this computational approach we aim to identify which functions can be inferred by systematic recordings of neuronal activity and connectivity. In addition, nuSPICs will help the design and application of new experimental paradigms based on the structure of the SNN and the presumed function which is to be discovered.

  4. Neural system prediction and identification challenge.

    Science.gov (United States)

    Vlachos, Ioannis; Zaytsev, Yury V; Spreizer, Sebastian; Aertsen, Ad; Kumar, Arvind

    2013-01-01

    Can we infer the function of a biological neural network (BNN) if we know the connectivity and activity of all its constituent neurons?This question is at the core of neuroscience and, accordingly, various methods have been developed to record the activity and connectivity of as many neurons as possible. Surprisingly, there is no theoretical or computational demonstration that neuronal activity and connectivity are indeed sufficient to infer the function of a BNN. Therefore, we pose the Neural Systems Identification and Prediction Challenge (nuSPIC). We provide the connectivity and activity of all neurons and invite participants (1) to infer the functions implemented (hard-wired) in spiking neural networks (SNNs) by stimulating and recording the activity of neurons and, (2) to implement predefined mathematical/biological functions using SNNs. The nuSPICs can be accessed via a web-interface to the NEST simulator and the user is not required to know any specific programming language. Furthermore, the nuSPICs can be used as a teaching tool. Finally, nuSPICs use the crowd-sourcing model to address scientific issues. With this computational approach we aim to identify which functions can be inferred by systematic recordings of neuronal activity and connectivity. In addition, nuSPICs will help the design and application of new experimental paradigms based on the structure of the SNN and the presumed function which is to be discovered.

  5. Orion Absolute Navigation System Progress and Challenges

    Science.gov (United States)

    Holt, Greg N.; D'Souza, Christopher

    2011-01-01

    The Orion spacecraft is being designed as NASA's next-generation exploration vehicle for crewed missions beyond Low-Earth Orbit. The navigation system for the Orion spacecraft is being designed in a Multi-Organizational Design Environment (MODE) team including contractor and NASA personnel. The system uses an Extended Kalman Filter to process measurements and determine the state. The design of the navigation system has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudorange and deltarange, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, pad alignment, cold start are discussed as are

  6. Decision-Making Amplification under Uncertainty: An Exploratory Study of Behavioral Similarity and Intelligent Decision Support Systems

    Science.gov (United States)

    Campbell, Merle Wayne

    2013-01-01

    Intelligent decision systems have the potential to support and greatly amplify human decision-making across a number of industries and domains. However, despite the rapid improvement in the underlying capabilities of these "intelligent" systems, increasing their acceptance as decision aids in industry has remained a formidable challenge.…

  7. Power system dynamics: same phenomena; new challenges

    Energy Technology Data Exchange (ETDEWEB)

    Mansour, Yakout; Vaahedi, Ebraim; Xu, Wilsun; Chang, Allen [British Columbia Hydro, Vancouver, BC (Canada). Regional System Planning

    1994-12-31

    This paper presents a summary of how a utility met some challenges recently in two areas: transient angular stability and voltage stability. The paper also includes a view of what is evolving in these two areas. (author) 7 refs., 11 figs., 1 tab.

  8. A systems approach for management of pests and pathogens of nursery crops

    Science.gov (United States)

    Jennifer L. Parke; Niklaus J. Grünwald

    2012-01-01

    Horticultural nurseries are heterogeneous and spatially complex agricultural systems, which present formidable challenges to management of diseases and pests. Moreover, nursery plants shipped interstate and internationally can serve as important vectors for pathogens and pests that threaten both agriculture and forestry. Current regulatory strategies to prevent this...

  9. Challenges in implementing electronic hand hygiene monitoring systems.

    Science.gov (United States)

    Conway, Laurie J

    2016-05-02

    Electronic hand hygiene (HH) monitoring systems offer the exciting prospect of a more precise, less biased measure of HH performance than direct observation. However, electronic systems are challenging to implement. Selecting a system that minimizes disruption to the physical infrastructure and to clinician workflow, and that fits with the organization's culture and budget, is challenging. Getting front-line workers' buy-in and addressing concerns about the accuracy of the system and how the data will be used are also difficult challenges. Finally, ensuring information from the system reaches front-line workers and is used by them to improve HH practice is a complex challenge. We describe these challenges in detail and suggests ways to overcome them. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  10. Challenges of communication system during emergency disaster ...

    African Journals Online (AJOL)

    The purpose of this review is to provide the overview of available systems and potential future systems for communication during disaster in Malaysia. Electronic searches in major subject loci databases such as MEDLINE (via PUBMED), Ovid, Science Direct, Scopus, IEEE Xplore digital library and Springer are used in ...

  11. Lifesaving emergency obstetric services are inadequate in south-west Ethiopia: a formidable challenge to reducing maternal mortality in Ethiopia.

    Science.gov (United States)

    Girma, Meseret; Yaya, Yaliso; Gebrehanna, Ewenat; Berhane, Yemane; Lindtjørn, Bernt

    2013-11-04

    Most maternal deaths take place during labour and within a few weeks after delivery. The availability and utilization of emergency obstetric care facilities is a key factor in reducing maternal mortality; however, there is limited evidence about how these institutions perform and how many people use emergency obstetric care facilities in rural Ethiopia. We aimed to assess the availability, quality, and utilization of emergency obstetric care services in the Gamo Gofa Zone of south-west Ethiopia. We conducted a retrospective review of three hospitals and 63 health centres in Gamo Gofa. Using a retrospective review, we recorded obstetric services, documents, cards, and registration books of mothers treated and served in the Gamo Gofa Zone health facilities between July 2009 and June 2010. There were three basic and two comprehensive emergency obstetric care qualifying facilities for the 1,740,885 people living in Gamo Gofa. The proportion of births attended by skilled attendants in the health facilities was 6.6% of expected births, though the variation was large. Districts with a higher proportion of midwives per capita, hospitals and health centres capable of doing emergency caesarean sections had higher institutional delivery rates. There were 521 caesarean sections (0.8% of 64,413 expected deliveries and 12.3% of 4,231 facility deliveries). We recorded 79 (1.9%) maternal deaths out of 4,231 deliveries and pregnancy-related admissions at institutions, most often because of post-partum haemorrhage (42%), obstructed labour (15%) and puerperal sepsis (15%). Remote districts far from the capital of the Zone had a lower proportion of institutional deliveries (4% of deliveries, much higher than the average 1.9%). Based on a population of 1.7 million people, there should be 14 basic and four comprehensive emergency obstetric care (EmOC) facilities in the Zone. Our study found that only three basic and two comprehensive EmOC service qualifying facilities serve this large population which is below the UN's minimum recommendation. The utilization of the existing facilities for delivery was also low, which is clearly inadequate to reduce maternal deaths to the MDG target.

  12. Homegarden systems: agricultural characteristics and challenges

    NARCIS (Netherlands)

    Hoogerbrugge, I.; Fresco, L.O.

    1993-01-01

    Many sources of informal, grey literature on agronomic aspects of homegardens are discussed with the aim to increase the understanding of current garden systems, of their evolution and of their potential for increasing food security

  13. Religious legal systems: challenges of the modernity

    Directory of Open Access Journals (Sweden)

    Д. В. Лук’янов

    2015-11-01

    Full Text Available The influence of world globalization processes on the development of the religious legal systems has been analyzed in the paper. Globalization processes in the XXI century are regarding individuals, nations, and civilizations. Global transformations lead to qualitative changes in the socio-cultural relations and actualize a wide range of issues which are related to the formation of a new world culture. Modern globalization takes diverse range of public relations in its own orbit. The relationship between the legal systems in the twentieth century is some of the most important aspects of this process. However, the interaction of legal systems has significant differences from the interaction of economies of different countries. There are actual economic relations domination of Western financial and economic institutions and standardization of relevant rules. But the attempts to apply this approach to law lead to resistance to Western standards and the spread of major civilizational conflicts in different parts of the world. Globalization should be based on respect for cultural, religious and legal diversity. It has to ensure preservation of forced “Westernisation”. Significant differences in the impact of globalization on the convergence of legal systems of Western law (Romano-Germanic and Anglo-American and their impact on religious legal systems of Muslim, Hindu and Jewish law must be emphasized. The religious legal systems are not exposed to other systems and the related changes. This is due to such features as the divine nature, increased stability, specific sources of law etc. An important issue that requires further study is the reverse influence which religious law exercises to secularized modern legal system.

  14. Challenges within ventilation systems during accident situations

    International Nuclear Information System (INIS)

    Neuberger, M.; Bletzer, P.; Fronhoefer, M.; Hardy, T.; Kuhn, W.; Ricketts, C.I.; Schmidmeier, K.H.

    1991-01-01

    To help estimate the mechanical loading at the service location two fluid dynamic codes were investigated. FLOWMASTER shows good results in generating the air-cleaning network and in calculating steady state conditions, but fails in calculating fluid dynamic transients. PROMO is very time consuming in generating the network, but one can obtain good results in calculating fluid dynamic transients. In addition to the challenges posed by elevated pressure, temperature, and air flow, the effects of shock waves, caused by explosions or hydrogen detonations must be considered. The problem of a 'shock-shock' in the flow after the diverging channel by high shock strengths were solved. In order to guarantee the safety margins of filter units during their entire service lives, filter performance needs to be verified under standardized test conditions that take into consideration the particularly adverse effects of filter exposure to super-saturated airflows and elevated differential pressure. The detail construction for a rig to type test filter units under fog conditions and increased pressure drop was finished, and the components of the test facility were chosen. (orig./DG)

  15. Past and future challenges in developing remote systems technology

    International Nuclear Information System (INIS)

    Ferguson, K.R.

    1978-01-01

    During the early development of remote systems for processing and examining fuel and materials from nuclear reactors, the facility designer and operator worked closely together to meet the challenges of this new field. Numerous challenges still face the nuclear remote systems engineer, e.g., the development of systems that reduce the exposure of workers, the need for advances in basic technology, and the development of cost-effective facilities. The solution to these and other challenges can be accelerated by an expanded program of information exchange, an aggressive development program, and improved project management procedures

  16. Power plant cooling systems: trends and challenges

    International Nuclear Information System (INIS)

    Rittenhouse, R.C.

    1979-01-01

    A novel design for an intake and discharge system at the Belle River plant is described followed by a general discussion of water intake screens and porous dikes for screening fish and zooplankton. The intake system for the San Onofre PWR plant is described and the state regulations controlling the use of water for power plants is discussed. The use of sewage effluent as a source of cooling water is mentioned with reference to the Palo Verde plant. Progress in dry cooling and a new wet/dry tower due to be installed at the San Juan plant towards the end of this year, complete the survey

  17. Orion Absolute Navigation System Progress and Challenge

    Science.gov (United States)

    Holt, Greg N.; D'Souza, Christopher

    2012-01-01

    The absolute navigation design of NASA's Orion vehicle is described. It has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary onboard measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudo-range and delta-range, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, and cold start are discussed as are strategies for whole and partial state updates as well as covariance considerations. Strategies are given for dealing with latent measurements and high-rate propagation using multi-rate architecture. The details of the rate groups and the data ow between the elements is discussed and evaluated.

  18. Cooperative mobility systems: The human factor challenges.

    NARCIS (Netherlands)

    Martens, Marieke; Kroon, Elisabeth

    2014-01-01

    This paper presents a vision on cooperative mobility systems from a human factors perspective. To create a common ground for future developments, it’s important to define the common research themes and knowledge gaps. This article presents what steps need to be taken in order to come to proper

  19. Challenges of communication system during emergency disaster ...

    African Journals Online (AJOL)

    pc

    2017-10-05

    Oct 5, 2017 ... 3.2.3.Satellite-Based Communication. Satellite-based communication is another alternative for communication in the event of disaster. Japan, United States of America and Russia are the countries that have utilised the system to disseminate emergency messages during previous disasters. Satellite-based.

  20. Health system challenges of NCDs in Tunisia.

    Science.gov (United States)

    Ben Romdhane, Habiba; Tlili, Faten; Skhiri, Afef; Zaman, Shahaduz; Phillimore, Peter

    2015-01-01

    The objective of this study was to present a qualitative 'situation analysis' of the healthcare system in Tunisia, as it applies to management of cardiovascular disease (CVD) and diabetes. A primary concern was the institutional capacity to manage non-communicable diseases (NCDs). Research took place during 2010 (analysis of official documents, semi-structured interviews with key informants, and case studies in four clinics). Walt and Gilson's framework (1994) for policy analysis was used: content, actors, context, and process. Problems of integration and coordination have compounded funding pressures. Despite its importance in Tunisian healthcare, primary health is ill-equipped to manage NCDs. With limited funds, and no referral or health information system, staff morale in the public sector was low. Private healthcare has been the main development filling the void. This study highlights major gaps in the implementation of a comprehensive approach to NCDs, which is an urgent task across the region. In strategic planning, research on the health system is vital; but the capacity within Ministries of Health to use research has first to be built, with a commitment to grounding policy change in evidence.

  1. Challenging obduracy: how local communities transform the energy system

    NARCIS (Netherlands)

    van der Schoor, Tineke; van Lente, Harro; Scholtens, Bert; Peine, Alexander

    Paper discussing the contribution of local energy initiatives to the energy transition in the Netherlands. Highlights: New energy movement challenges present governance of energy system. Sustainability and strengthening regional economy are primary goals. Democratic cooperative model should

  2. Challenges facing transactional e-government systems

    OpenAIRE

    AI-Sebie, Madi M

    2005-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 17/10/2005. A review of normative literature, in the field of e-government, indicates that the transactional stage of e-government is one of the most important to the implementation of an e-government system as it represents the highest level of interaction within organisations and between customers and government organisations. Due to the importance of the transactional stage of the e-govern...

  3. ATLAS LTCS Vertically Challenged System Lessons Learned

    Science.gov (United States)

    Patel, Deepak; Garrison, Matt; Ku, Jentung

    2014-01-01

    Re-planning of LTCS TVAC testing and supporting RTA (Receiver Telescope Assembly) Test Plan and Procedure document preparation. The Laser Thermal Control System (LTCS) is designed to maintain the lasers onboard Advanced Topographic Laser Altimeter System (ATLAS) at their operational temperatures. In order to verify the functionality of the LTCS, a thermal balance test of the thermal hardware was performed. During the first cold start of the LTCS, the Loop Heat Pipe (LHP) was unable to control the laser mass simulators temperature. The control heaters were fully on and the loop temperature remained well below the desired setpoint. Thermal analysis of the loop did not show these results. This unpredicted behavior of the LTCS was brought up to a panel of LHP experts. Based on the testing and a review of all the data, there were multiple diagnostic performed in order to narrow down the cause. The prevailing theory is that gravity is causing oscillating flow within the loop, which artificially increased the control power needs. This resulted in a replan of the LTCS test flow and the addition of a GSE heater to allow vertical operation.

  4. Improving cold chain systems: Challenges and solutions.

    Science.gov (United States)

    Ashok, Ashvin; Brison, Michael; LeTallec, Yann

    2017-04-19

    While a number of new vaccines have been rolled out across the developing world (with more vaccines in the pipeline), cold chain systems are struggling to efficiently support national immunization programs in ensuring the availability of safe and potent vaccines. This article reflects on the Clinton Health Access Initiative, Inc. (CHAI) experience working since 2010 with national immunization programs and partners to improve vaccines cold chains in 10 countries-Ethiopia, Nigeria, Kenya, Malawi, Tanzania, Uganda, Cameroon, Mozambique, Lesotho and India - to identify the root causes and solutions for three common issues limiting cold chain performance. Key recommendations include: Collectively, the solutions detailed in this article chart a path to substantially improving the performance of the cold chain. Combined with an enabling global and in-country environment, it is possible to eliminate cold chain issues as a substantial barrier to effective and full immunization coverage over the next few years. Copyright © 2017. Published by Elsevier Ltd.

  5. The computational challenges of Earth-system science.

    Science.gov (United States)

    O'Neill, Alan; Steenman-Clark, Lois

    2002-06-15

    The Earth system--comprising atmosphere, ocean, land, cryosphere and biosphere--is an immensely complex system, involving processes and interactions on a wide range of space- and time-scales. To understand and predict the evolution of the Earth system is one of the greatest challenges of modern science, with success likely to bring enormous societal benefits. High-performance computing, along with the wealth of new observational data, is revolutionizing our ability to simulate the Earth system with computer models that link the different components of the system together. There are, however, considerable scientific and technical challenges to be overcome. This paper will consider four of them: complexity, spatial resolution, inherent uncertainty and time-scales. Meeting these challenges requires a significant increase in the power of high-performance computers. The benefits of being able to make reliable predictions about the evolution of the Earth system should, on their own, amply repay this investment.

  6. Grand societal challenges in information systems research and education

    CERN Document Server

    vom Brocke, Jan; Hofmann, Sara; Tumbas, Sanja

    2015-01-01

    This book examines how information systems research and education can play a major role in contributing to solutions to the Societal Grand Challenges formulated in "The Millennium Project" (millenium-project.org). Individual chapters focus on specific challenges, review existing approaches and contributions towards solutions in information systems research and outline a research agenda for these challenges. The topics considered in this volume range from climate change, population growth, global ICT availability, breakthroughs in science and technology and energy demand to ethical decision-making, policymaking, gender status and transnational crime prevention. It is the first book to present ideas on how the Information Systems discipline can contribute to the solution on this wide spectrum of grand societal challenges.

  7. Preferences in Interactive Systems: Technical Challenges and Case Studies

    OpenAIRE

    Peintner, Bart; Viappiani, Paolo; Yorke-Smith, Neil

    2008-01-01

    Interactive artificial intelligence systems employ preferences in both their reasoning and their interaction with the user. This survey considers preference handling in applications such as recommender systems, personal assistant agents, and personalized user interfaces. We survey the major questions and approaches, present illustrative examples, and give an outlook on potential benefits and challenges.

  8. Subclinical primary psychopathy, but not physical formidability or attractiveness, predicts conversational dominance in a zero-acquaintance situation.

    Science.gov (United States)

    Manson, Joseph H; Gervais, Matthew M; Fessler, Daniel M T; Kline, Michelle A

    2014-01-01

    The determinants of conversational dominance are not well understood. We used videotaped triadic interactions among unacquainted same-sex American college students to test predictions drawn from the theoretical distinction between dominance and prestige as modes of human status competition. Specifically, we investigated the effects of physical formidability, facial attractiveness, social status, and self-reported subclinical psychopathy on quantitative (proportion of words produced), participatory (interruptions produced and sustained), and sequential (topic control) dominance. No measure of physical formidability or attractiveness was associated with any form of conversational dominance, suggesting that the characteristics of our study population or experimental frame may have moderated their role in dominance dynamics. Primary psychopathy was positively associated with quantitative dominance and (marginally) overall triad talkativeness, and negatively associated (in men) with affect word use, whereas secondary psychopathy was unrelated to conversational dominance. The two psychopathy factors had significant opposing effects on quantitative dominance in a multivariate model. These latter findings suggest that glibness in primary psychopathy may function to elicit exploitable information from others in a relationally mobile society.

  9. Subclinical primary psychopathy, but not physical formidability or attractiveness, predicts conversational dominance in a zero-acquaintance situation.

    Directory of Open Access Journals (Sweden)

    Joseph H Manson

    Full Text Available The determinants of conversational dominance are not well understood. We used videotaped triadic interactions among unacquainted same-sex American college students to test predictions drawn from the theoretical distinction between dominance and prestige as modes of human status competition. Specifically, we investigated the effects of physical formidability, facial attractiveness, social status, and self-reported subclinical psychopathy on quantitative (proportion of words produced, participatory (interruptions produced and sustained, and sequential (topic control dominance. No measure of physical formidability or attractiveness was associated with any form of conversational dominance, suggesting that the characteristics of our study population or experimental frame may have moderated their role in dominance dynamics. Primary psychopathy was positively associated with quantitative dominance and (marginally overall triad talkativeness, and negatively associated (in men with affect word use, whereas secondary psychopathy was unrelated to conversational dominance. The two psychopathy factors had significant opposing effects on quantitative dominance in a multivariate model. These latter findings suggest that glibness in primary psychopathy may function to elicit exploitable information from others in a relationally mobile society.

  10. Subclinical Primary Psychopathy, but Not Physical Formidability or Attractiveness, Predicts Conversational Dominance in a Zero-Acquaintance Situation

    Science.gov (United States)

    Manson, Joseph H.; Gervais, Matthew M.; Fessler, Daniel M. T.; Kline, Michelle A.

    2014-01-01

    The determinants of conversational dominance are not well understood. We used videotaped triadic interactions among unacquainted same-sex American college students to test predictions drawn from the theoretical distinction between dominance and prestige as modes of human status competition. Specifically, we investigated the effects of physical formidability, facial attractiveness, social status, and self-reported subclinical psychopathy on quantitative (proportion of words produced), participatory (interruptions produced and sustained), and sequential (topic control) dominance. No measure of physical formidability or attractiveness was associated with any form of conversational dominance, suggesting that the characteristics of our study population or experimental frame may have moderated their role in dominance dynamics. Primary psychopathy was positively associated with quantitative dominance and (marginally) overall triad talkativeness, and negatively associated (in men) with affect word use, whereas secondary psychopathy was unrelated to conversational dominance. The two psychopathy factors had significant opposing effects on quantitative dominance in a multivariate model. These latter findings suggest that glibness in primary psychopathy may function to elicit exploitable information from others in a relationally mobile society. PMID:25426962

  11. Shared Electronic Health Record Systems: Key Legal and Security Challenges.

    Science.gov (United States)

    Christiansen, Ellen K; Skipenes, Eva; Hausken, Marie F; Skeie, Svein; Østbye, Truls; Iversen, Marjolein M

    2017-11-01

    Use of shared electronic health records opens a whole range of new possibilities for flexible and fruitful cooperation among health personnel in different health institutions, to the benefit of the patients. There are, however, unsolved legal and security challenges. The overall aim of this article is to highlight legal and security challenges that should be considered before using shared electronic cooperation platforms and health record systems to avoid legal and security "surprises" subsequent to the implementation. Practical lessons learned from the use of a web-based ulcer record system involving patients, community nurses, GPs, and hospital nurses and doctors in specialist health care are used to illustrate challenges we faced. Discussion of possible legal and security challenges is critical for successful implementation of shared electronic collaboration systems. Key challenges include (1) allocation of responsibility, (2) documentation routines, (3) and integrated or federated access control. We discuss and suggest how challenges of legal and security aspects can be handled. This discussion may be useful for both current and future users, as well as policy makers.

  12. A Formidable Task: Reflections on obtaining legal empirical evidence on human trafficking in Canada

    OpenAIRE

    Hayli Millar; Tamara O'Doherty; Katrin Roots

    2017-01-01

    This article explores the experiences, challenges and findings of two empirical research studies examining Canada’s legal efforts to combat human trafficking. The authors outline the methodologies of their respective studies and reflect on some of the difficulties they faced in obtaining empirical data on human trafficking court cases and legal proceedings. Ultimately, the authors found that Canadian trafficking case law developments are in their early stages with very few convictions, despit...

  13. Challenge-driven attention: interacting frontal and brainstem systems

    Directory of Open Access Journals (Sweden)

    Rajeev D S Raizada

    2008-03-01

    Full Text Available The world is an unpredictable place, presenting challenges that fl uctuate from moment to moment. However, the neural systems for responding to such challenges are far from fully understood. Using fMRI, we studied an audiovisual task in which the trials' diffi culty and onset times varied unpredictably. Two regions were found to increase their activation for challenging trials, with their activities strongly correlated: right frontal cortex and the brainstem. The frontal area matched regions found in previous human studies of cognitive control, and activated in a graded manner with increasing task diffi culty. The brainstem responded only to the most diffi cult trials, showing a phasic activity pattern paralleling locus coeruleus recordings in monkeys. These results reveal a bridge between animal and human studies, and suggest interacting roles for the brainstem and right frontal cortex: the brainstem may signal that an attentional challenge is occurring, while right frontal cortex allocates cognitive resources in response.

  14. Technical challenges to energy systems' operation and markets

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, P.; Meibom, P.; Gehrke, O. [Risoe National Lab. (Denmark); Oestergaard, J. [Technical Univ. of Denmark (Denmark)

    2006-11-15

    A future energy system that includes a high proportion of renewable energy will be expected to meet the same requirements for security of supply and economic efficiency as the energy systems of today, while delivering better environmental performance, especially with regard to CO{sub 2} emissions. Security of supply refers to the long-term reliability of fuel supply; especially in power systems, it also covers short-term requirements for system stability and adequacy. Economic efficiency is concerned with getting the best from the significant amounts of money, human capital and natural resources involved in an energy system. Integral to economic efficiency in energy systems is the presence of well-functioning markets for energy services. The variability and reduced predictability of a number of renewable energy sources, notably wind power, create specific challenges for future energy systems compared to those of today. Power transmission will also become an issue, as the areas with good potential for wind power and wave energy are often located some distance from the centres of power consumption. This chapter describes the challenges involved, and possible solutions to these, with a focus on power systems. The chapter is divided into two sections reflecting the fact that some challenges relate to managing the power system in its normal operation mode, whereas others are specific to fault conditions. (au)

  15. A Systems Thinking Approach to Engineering Challenges of Military Systems-of-Systems

    Science.gov (United States)

    2016-09-01

    as part of organizational thinking , processes and practice; and 2) an adequate SoSE practice supporting environment created and used to enable SoS...UNCLASSIFIED UNCLLASIFIED A Systems Thinking Approach to Engineering Challenges of Military Systems-of-Systems Pin Chen and Mark...their products and outcomes. This report introduces a systems thinking -based approach, SoS thinking , which offers a language and a thoughtful process

  16. Methods and metrics challenges of delivery-system research

    Directory of Open Access Journals (Sweden)

    Alexander Jeffrey A

    2012-03-01

    Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

  17. Challenges in the analysis of complex systems: introduction and overview

    Science.gov (United States)

    Hastings, Harold M.; Davidsen, Jörn; Leung, Henry

    2017-12-01

    One of the main challenges of modern physics is to provide a systematic understanding of systems far from equilibrium exhibiting emergent behavior. Prominent examples of such complex systems include, but are not limited to the cardiac electrical system, the brain, the power grid, social systems, material failure and earthquakes, and the climate system. Due to the technological advances over the last decade, the amount of observations and data available to characterize complex systems and their dynamics, as well as the capability to process that data, has increased substantially. The present issue discusses a cross section of the current research on complex systems, with a focus on novel experimental and data-driven approaches to complex systems that provide the necessary platform to model the behavior of such systems.

  18. Case prediction in BPM systems : a research challenge

    NARCIS (Netherlands)

    Reijers, H.A.

    2007-01-01

    The capabilities of Business Process Management Systems (BPMS's) are continuously extended to increase the effectiveness of the management and enactment of business processes. This paper identifies the challenge of case prediction, which for a specific case under the control of a BPMS deals with the

  19. The Almajiri educational system in Nigeria: cost and challenges ...

    African Journals Online (AJOL)

    The cost implications of Almajiri system include human resources wastage, exposure of children to harsh environmental hazards, and deprivation of these children of parental care. The paper also highlighted on the major challenges to include illiterate teachers involve in teaching the children, lack of basic infrastructural ...

  20. Material challenges for the next generation of fission reactor systems

    International Nuclear Information System (INIS)

    Buckthorpe, Derek

    2010-01-01

    The new generation of fission reactor systems wil require the deployment and construction of a series of advanced water cooled reactors as part of a package of measures to meet UK and European energy needs and to provide a near term non-fossil fuel power solution that addresses CO 2 emission limits. In addition new longer term Generation IV reactor tye systems are being developed and evaluated to enhance safety, reliability, sustainability economics and proliferation resistance requirements and to meet alternative energy applications (outside of electricity generation) such as process heat and large scale hydrogen generation. New fission systems will impose significant challenges on materials supply and development. In the near term, because of the need to 'gear up' to large scale construction after decades of industrial hibernation/contraction and, in the longer term, because of the need for materials to operate under more challenging environments requiring the deployment and development of new alternative materials not yet established to an industrial stage. This paper investigates the materials challenges imposed by the new Generation III+ and Generation IV systems. These include supply and fabrication issues, development of new high temperature alloys and non-metallic materials, the use of new methods of manufacture and the best use of currently available resources and minerals. Recommendations are made as to how these materials challenges might be met and how governments, industry, manufacturers and researchers can all play their part. (orig.)

  1. A System of Movement and Motor Skill Challenges for Children

    Science.gov (United States)

    Hill, Grant M.; Turner, Bud

    2012-01-01

    Given increasing childhood inactivity and obesity, and minimal time for quality physical education in elementary and secondary schools, it is essential that children are motivated and held accountable for independent motor and movement skill practice. The Movement and Motor Skill Challenge System provides a comprehensive set of stimulating,…

  2. Electronic Payment System in Nigeria: Its Economic Benefits and Challenges

    Science.gov (United States)

    Okifo, Joseph; Igbunu, Richard

    2015-01-01

    The crux of this study is on the adoption of E-payment system in Nigeria: Its economic benefits and challenges. The arrival of the internet has taken electronic payments and transactions to an exponential growth level. Consumers could purchase goods and services from the internet and send unencrypted credit card numbers across the network, which…

  3. Material challenges for the next generation of fission reactor systems

    Energy Technology Data Exchange (ETDEWEB)

    Buckthorpe, Derek [AMEC, Knutsford, Cheshire (United Kingdom)

    2010-07-01

    The new generation of fission reactor systems wil require the deployment and construction of a series of advanced water cooled reactors as part of a package of measures to meet UK and European energy needs and to provide a near term non-fossil fuel power solution that addresses CO{sub 2} emission limits. In addition new longer term Generation IV reactor tye systems are being developed and evaluated to enhance safety, reliability, sustainability economics and proliferation resistance requirements and to meet alternative energy applications (outside of electricity generation) such as process heat and large scale hydrogen generation. New fission systems will impose significant challenges on materials supply and development. In the near term, because of the need to 'gear up' to large scale construction after decades of industrial hibernation/contraction and, in the longer term, because of the need for materials to operate under more challenging environments requiring the deployment and development of new alternative materials not yet established to an industrial stage. This paper investigates the materials challenges imposed by the new Generation III+ and Generation IV systems. These include supply and fabrication issues, development of new high temperature alloys and non-metallic materials, the use of new methods of manufacture and the best use of currently available resources and minerals. Recommendations are made as to how these materials challenges might be met and how governments, industry, manufacturers and researchers can all play their part. (orig.)

  4. Educator Perspectives on Earth System Science Literacy: Challenges and Priorities

    Science.gov (United States)

    LaDue, Nicole; Clark, Scott K.

    2012-01-01

    The challenges and priorities of defining and achieving Earth System Science (ESS) literacy are examined through surveys of geoscience educators attending a professional geological meeting. Two surveys with Likert-style and free-response questions were distributed to geoscientists and K-12 teachers to elicit what instructors think are important…

  5. Human capital flight challenges within an Equitable Health System ...

    African Journals Online (AJOL)

    Human capital flight challenges within an Equitable Health System. N E Udonwa. Abstract. No Abstract Nigerian Journal of Medicine Vol. 16 (4) 2007: pp. 307-311. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/njm.v16i4.37327 · AJOL African ...

  6. Control Engineering, System Theory and Mathematics: The Teacher's Challenge

    Science.gov (United States)

    Zenger, K.

    2007-01-01

    The principles, difficulties and challenges in control education are discussed and compared to the similar problems in the teaching of mathematics and systems science in general. The difficulties of today's students to appreciate the classical teaching of engineering disciplines, which are based on rigorous and scientifically sound grounds, are…

  7. A Formidable Task: Reflections on obtaining legal empirical evidence on human trafficking in Canada

    Directory of Open Access Journals (Sweden)

    Hayli Millar

    2017-04-01

    Full Text Available This article explores the experiences, challenges and findings of two empirical research studies examining Canada’s legal efforts to combat human trafficking. The authors outline the methodologies of their respective studies and reflect on some of the difficulties they faced in obtaining empirical data on human trafficking court cases and legal proceedings. Ultimately, the authors found that Canadian trafficking case law developments are in their early stages with very few convictions, despite a growing number of police-reported charges. The authors assert it is difficult to assess the efficacy and effects of Canadian anti-trafficking laws and policies due to the institutional and political limitations to collecting legal data in this highly politicised subject area. They conclude with five recommendations to increase the transparency of Canada’s public claims about its anti-trafficking enforcement efforts and call for more empirically-based law reform.

  8. An Open Challenge Problem Repository for Systems Supporting Binders

    OpenAIRE

    Felty, A.; Momigliano, A.; Pientka, B.

    2015-01-01

    A variety of logical frameworks support the use of higher-order abstract syntax in representing formal systems; however, each system has its own set of benchmarks. Even worse, general proof assistants that provide special libraries for dealing with binders offer a very limited evaluation of such libraries, and the examples given often do not exercise and stress-test key aspects that arise in the presence of binders. In this paper we design an open repository ORBI (Open challenge problem Repo...

  9. Nanomedical device and systems design challenges, possibilities, visions

    CERN Document Server

    2014-01-01

    Nanomedical Device and Systems Design: Challenges, Possibilities, Visions serves as a preliminary guide toward the inspiration of specific investigative pathways that may lead to meaningful discourse and significant advances in nanomedicine/nanotechnology. This volume considers the potential of future innovations that will involve nanomedical devices and systems. It endeavors to explore remarkable possibilities spanning medical diagnostics, therapeutics, and other advancements that may be enabled within this discipline. In particular, this book investigates just how nanomedical diagnostic and

  10. Challenges for maintaining the modernization of instrumentation and control systems

    International Nuclear Information System (INIS)

    Rojas, V.

    2014-01-01

    Instrumentation and control system upgrades in nuclear power plants come with some challenges for their maintenance staff. It is important to have a long term modernization plant that derives from specific studies for each system. Training, spares, configuration control and cybersecurity are critical topics to take into account from the beginning of these projects. New system maintenance plans can require a new approach in accordance with the technology. FPGAs (Field Programmable Gate Array) appear as the alternative for the future, mainly in safety systems. (Author)

  11. Challenges to China's transition to a low carbon electricity system

    International Nuclear Information System (INIS)

    Kahrl, Fredrich; Williams, Jim; Ding Jianhua; Hu Junfeng

    2011-01-01

    We examine the challenges to China's transition to a low carbon electricity system, in which renewable energy would play a significant role. China's electricity system currently lacks the flexibility in planning, operations, and pricing to respond to conflicting pressures from demand growth, rising costs, and environmental mandates in a way that simultaneously maintains reliability, decarbonizes the system, and keeps prices within acceptable bounds. Greater flexibility crucially requires the ability to more systematically and transparently manage and allocate costs. This will require re-orientating sector institutions still rooted in central planning, and strengthening independent regulation. Some of the necessary changes require fundamental political and legal reforms beyond the scope of energy policy. However, the system's flexibility can still be increased through the development of traditional planning and regulatory tools and approaches, such as an avoided cost basis for energy efficiency investments, more integrated planning to improve the coordination of generation, transmission, and demand-side investments, and a transparent ratemaking process. The judicious application of OECD electricity sector experience and skills can support these developments. - Research highlights: → China's electricity system currently lacks the flexibility to integrate renewables and reduce CO 2 emissions on a large scale at an acceptable cost and level of reliability. → The challenges to increased flexibility are more institutional than technological. → Chinese government agencies need new approaches to basic power system planning and ratemaking. → OECD countries can help address these challenges through the transfer of 'soft' technologies.

  12. Innovation in Extraterrestrial Service Systems - A Challenge for Service Science

    Science.gov (United States)

    Bergner, David

    2010-01-01

    This presentation was prepared at the invitation of Professor Yukio Ohsawa, Department of Systems Innovation, School of Engineering, The University of Tokyo, for delivery at the International Workshop on Innovating Service Systems, sponsored by the Japanese Society of Artificial Intelligence (JSAI) as part of the JSAI Internation Symposium on AI, 2010. It offers several challenges for Service Science and Service Innovation. the goal of the presentation is to stimulate thinking about how service systems viII evolve in the future, as human society advances from its terrestrial base toward a permanent presence in space. First we will consider the complexity of the International Space Station (ISS) as it is today, with particular emphasis of its research facilities, and focus on a current challenge - to maximize the utilization of ISS research facilities for the benefit of society. After briefly reviewing the basic principles of Service Science, we will discuss the potential application of Service Innovation methodology to this challenge. Then we viII consider how game-changing technologies - in particular Synthetic Biology - could accelerate the pace of sociocultural evolution and consequently, the progression of human society into space. We will use this provocative vision to advance thinking about how the emerging field of Service Science, Management, and Engineering (SSME) might help us anticipate and better handle the challenges of this inevitable evolutionary process.

  13. Assessment in Open and Distance Learning System (ODL: A Challenge

    Directory of Open Access Journals (Sweden)

    S. V. S. Chaudhary

    2013-09-01

    Full Text Available Assessment is an integral part of the learning process. The traditional practice of assessment has changed to meet the need of the contemporary society. In this paper assessment strategies used in Open and Distance Education are discussed and constructive suggestions are given to meet the challenges of assessment. Recently we experience a paradigm shift in assessment both in face-to-face and ODL system. Content-based testing has shifted to performance-based assessment. Assessment is no longer used for grading and certification, rather it has linked with learning and skill development of the students. Instead of a single paper pencil test, a variety of techniques and methods are being increasingly conducted. In this context assessment in the ODL system has adopted a new shape to provide better assessment judgments to its students and at the same time helping teachers and administrators. Coping with the changing scenario in ODL we face challenges addressed extensively in this article.

  14. Challenges, issues and trends in fall detection systems

    Science.gov (United States)

    2013-01-01

    Since falls are a major public health problem among older people, the number of systems aimed at detecting them has increased dramatically over recent years. This work presents an extensive literature review of fall detection systems, including comparisons among various kinds of studies. It aims to serve as a reference for both clinicians and biomedical engineers planning or conducting field investigations. Challenges, issues and trends in fall detection have been identified after the reviewing work. The number of studies using context-aware techniques is still increasing but there is a new trend towards the integration of fall detection into smartphones as well as the use of machine learning methods in the detection algorithm. We have also identified challenges regarding performance under real-life conditions, usability, and user acceptance as well as issues related to power consumption, real-time operations, sensing limitations, privacy and record of real-life falls. PMID:23829390

  15. Pilot Implementation of Health Information Systems: Issues and challenges

    DEFF Research Database (Denmark)

    Bansler, Jørgen Peter; Havn, Erling C.

    2010-01-01

    Objectives: This study aims to explore the issues and challenges involved in designing and organizing pilot implementations of health information systems (HIS). Pilot implementations are a widely used approach for identifying design flaws and implementation issues before full-scale deployment...... of conventional implementations; they are fundamentally different and they have their own complications and issues to deal with that make them hard to design and manage....

  16. Electronic health systems: challenges faced by hospital-based providers.

    Science.gov (United States)

    Agno, Christina Farala; Guo, Kristina L

    2013-01-01

    The purpose of this article is to discuss specific challenges faced by hospitals adopting the use of electronic medical records and implementing electronic health record (EHR) systems. Challenges include user and information technology support; ease of technical use and software interface capabilities; compliance; and financial, legal, workforce training, and development issues. Electronic health records are essential to preventing medical errors, increasing consumer trust and use of the health system, and improving quality and overall efficiency. Government efforts are focused on ways to accelerate the adoption and use of EHRs as a means of facilitating data sharing, protecting health information privacy and security, quickly identifying emerging public health threats, and reducing medical errors and health care costs and increasing quality of care. This article will discuss physician and nonphysician staff training before, during, and after implementation; the effective use of EHR systems' technical features; the selection of a capable and secure EHR system; and the development of collaborative system implementation. Strategies that are necessary to help health care providers achieve successful implementation of EHR systems will be addressed.

  17. Smart wearable systems: current status and future challenges.

    Science.gov (United States)

    Chan, Marie; Estève, Daniel; Fourniols, Jean-Yves; Escriba, Christophe; Campo, Eric

    2012-11-01

    Extensive efforts have been made in both academia and industry in the research and development of smart wearable systems (SWS) for health monitoring (HM). Primarily influenced by skyrocketing healthcare costs and supported by recent technological advances in micro- and nanotechnologies, miniaturisation of sensors, and smart fabrics, the continuous advances in SWS will progressively change the landscape of healthcare by allowing individual management and continuous monitoring of a patient's health status. Consisting of various components and devices, ranging from sensors and actuators to multimedia devices, these systems support complex healthcare applications and enable low-cost wearable, non-invasive alternatives for continuous 24-h monitoring of health, activity, mobility, and mental status, both indoors and outdoors. Our objective has been to examine the current research in wearable to serve as references for researchers and provide perspectives for future research. Herein, we review the current research and development of and the challenges facing SWS for HM, focusing on multi-parameter physiological sensor systems and activity and mobility measurement system designs that reliably measure mobility or vital signs and integrate real-time decision support processing for disease prevention, symptom detection, and diagnosis. For this literature review, we have chosen specific selection criteria to include papers in which wearable systems or devices are covered. We describe the state of the art in SWS and provide a survey of recent implementations of wearable health-care systems. We describe current issues, challenges, and prospects of SWS. We conclude by identifying the future challenges facing SWS for HM. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Big data in complex systems challenges and opportunities

    CERN Document Server

    Azar, Ahmad; Snasael, Vaclav; Kacprzyk, Janusz; Abawajy, Jemal

    2015-01-01

    This volume provides challenges and Opportunities with updated, in-depth material on the application of Big data to complex systems in order to find solutions for the challenges and problems facing big data sets applications. Much data today is not natively in structured format; for example, tweets and blogs are weakly structured pieces of text, while images and video are structured for storage and display, but not for semantic content and search. Therefore transforming such content into a structured format for later analysis is a major challenge. Data analysis, organization, retrieval, and modeling are other  foundational challenges treated in this book. The material of this book will be useful for researchers and practitioners in the field of big data as well as advanced undergraduate and graduate  students. Each of the 17 chapters in the book opens with a chapter abstract and key terms list. The chapters are organized along the lines of problem description, related works, and analysis of the results and ...

  19. Challenges in designing interactive systems for emergency response

    DEFF Research Database (Denmark)

    Kristensen, Margit; Kyng, Morten; Nielsen, Esben Toftdahl

    2007-01-01

    and visions as ways to bridge between fieldwork and literature studies on the one hand and the emerging computer based prototypes on the other. Our case concerns design of innovative interactive systems for support in emergency response, including patient identification and monitoring as well as construction......This paper presents research on participatory design of interactive systems for emergency response. We present the work by going through the design method with a focus on the new elements that we developed for the participatory design toolkit, in particular we emphasize the use of challenges...

  20. Technology, Applications, and Process Challenges of Dual Chamber Systems.

    Science.gov (United States)

    Werk, Tobias; Ludwig, Imke S; Luemkemann, Joerg; Mahler, Hanns-Christian; Huwyler, Joerg; Hafner, Mathias

    2016-01-01

    Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes. Copyright © 2016. Published by Elsevier Inc.

  1. Challenges at different stages of an iris based biometric system

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Singla

    2012-04-01

    Full Text Available Iris recognition has been used for authentication for the past few years and is capable of positive/negative authenticationof an individual without any physical contact or intervention. This technique is being used mainly because of its uniqueness,stability, and reliability but still many challenges are being faced an the iris based recognition system. This paperpresents the difficulties faced in different modules, like the sensor module, preprocessing module, feature extraction module,and matching module of an iris biometric system.

  2. Challenges in data science: a complex systems perspective

    International Nuclear Information System (INIS)

    Carbone, Anna; Jensen, Meiko; Sato, Aki-Hiro

    2016-01-01

    The ability to process and manage large data volumes has been proven to be not enough to tackle the current challenges presented by “Big Data”. Deep insight is required for understanding interactions among connected systems, space- and time- dependent heterogeneous data structures. Emergence of global properties from locally interacting data entities and clustering phenomena demand suitable approaches and methodologies recently developed in the foundational area of Data Science by taking a Complex Systems standpoint. Here, we deal with challenges that can be summarized by the question: “What can Complex Systems Science contribute to Big Data? ”. Such question can be reversed and brought to a superior level of abstraction by asking “What Knowledge can be drawn from Big Data?” These aspects constitute the main motivation behind this article to introduce a volume containing a collection of papers presenting interdisciplinary advances in the Big Data area by methodologies and approaches typical of the Complex Systems Science, Nonlinear Systems Science and Statistical Physics.

  3. Challenge of Replacing Obsolete Equipment and Systems on Brownfield Sites

    International Nuclear Information System (INIS)

    Teasdale, St.

    2009-01-01

    The Nuclear Decommissioning Authority (NDA) is responsible for the decommissioning and clean-up of the UK's civil public sector nuclear sites. One of their top priorities is the retrieval of sludge and fuel from the First Generation Magnox Fuel Storage Pond (FGMSP) at Sellafield site which is one of the most complex and compact nuclear sites in the world. The FGMSP plant is currently undergoing a series of major modifications in preparation for the retrievals operations. One of the most challenging modifications undertaken in the facility has been the Control and Surveillance Project which covered replacement of the existing Environmental Monitoring System, this presented the complex challenge of replacing an existing system whilst maintaining full functionality on a live radiological safety system with a constant radiological hazard. The Control and Surveillance Project involved the design, procurement, installation, changeover and commissioning of a new Radiological Surveillance System (alpha, beta and gamma monitoring) along with Building Evacuation Systems within the FGMSP complex to replace the existing obsolete system. This Project was a key enabler to future FGMSP retrievals and decommissioning activities. The project objective was to create and maintain a safe radiological working environment for over 450 personnel working in the plant up to 2020. The Legacy Ponds at Sellafield represent one of the biggest challenges in the civil nuclear clean up portfolio in the UK. Retrieval of sludge and fuel from the First Generation Magnox Fuel Storage Pond (FGMSP), and its safe long term storage is one of the NDA's top priorities. In June 2002 Sellafield Ltd contracted with the ACKtiv Nuclear Joint Venture to progress the risk mitigation, asset restoration and the early enabling works associated with preparation for clean up. Since then significant progress has been made in preparing the facility, and it's support systems, for the clean-up operations. This has been

  4. Challenges in Quantitative Abstractions for Collective Adaptive Systems

    Directory of Open Access Journals (Sweden)

    Mirco Tribastone

    2016-07-01

    Full Text Available Like with most large-scale systems, the evaluation of quantitative properties of collective adaptive systems is an important issue that crosscuts all its development stages, from design (in the case of engineered systems to runtime monitoring and control. Unfortunately it is a difficult problem to tackle in general, due to the typically high computational cost involved in the analysis. This calls for the development of appropriate quantitative abstraction techniques that preserve most of the system's dynamical behaviour using a more compact representation. This paper focuses on models based on ordinary differential equations and reviews recent results where abstraction is achieved by aggregation of variables, reflecting on the shortcomings in the state of the art and setting out challenges for future research.

  5. Accomplishments and challenges in development of an autonomous operation system

    International Nuclear Information System (INIS)

    Endou, A.; Saiki, A.; Yoshikawa, S.; Okusa, K.; Suda, K.

    1994-01-01

    The authors are studying an autonomous operation system for nuclear power plants in which AI plays key roles as an alternative of plant operators and traditional controllers. In contrast with past studies dedicated to assist the operators, the ultimate target of development of the autonomous operation system is to operate the nuclear plants by AI. To realize humanlike decision-making process by means of AI, the authors used a model-based approach from multiple viewpoints and methodology diversity. A hierarchical distributed cooperative multi-agent system configuration is adopted to allow to incorporate diversified methodologies and to dynamically reorganize system functions. In the present paper, accomplishments to date in the course of the development are described. Challenges for developing methodologies to attain dynamic reorganization are also addressed. (author)

  6. International outsourcing as a challenge for the world trade system

    Directory of Open Access Journals (Sweden)

    Elena Sivacheva

    2007-02-01

    Full Text Available From the strategic management point of view, the twenty-first century is being widely recognized as the century for outsourcing in the global economy. In the meantime international outsourcing is one of the most dynamic, innovation-driven and complicated processes in modern world. The present paper concentrates on the essence of international outsourcing (tracing its roots in the international division of labour and world economic relations theoretical approaches, reviews its explicit and implicit challenges and finally presents opportunities for regulating international outsourcing. Attention is focused on the following key questions: to what extent does international outsourcing represent a challenge for the world trade system? what contribution does international outsourcing make to economic «strength» in the modern world?

  7. Challenges and Success Factors of ERP Systems in Australian SMEs

    Directory of Open Access Journals (Sweden)

    Sitalakshmi Venkatraman

    2016-05-01

    Full Text Available Today, great potential is envisaged for ERP systems in small and medium-sized enterprises (SMEs, and software vendors have been repackaging their ERP systems for SMEs with a recent focus on cloud-based systems. While cloud ERP offers the best solution for SMEs without the overheads of the huge investment and management costs that are associated with traditional ERP systems, the SME sector faces many challenges in their adoption. Traditional ERP studies have predominantly focused on large organizations, and gaps in the literature indicate that both vendor and consumer perspectives require more understanding with new technology offerings for SMEs. This paper describes some of the common challenges, such as cost effectiveness, alignment between software and business processes, customized governance and training, which form the major SME constraints for ERP system adoption. Due to the dynamic nature of SME businesses, best practice guidelines for an SME’s ERP implementation could be arrived at through closer investigation of its business requirements in order to avoid misfits. This forms the main objective of the study. We identify key success factors of ERP implementation in an Australian SME as a case study. These target success factors are then compared to the actual outcomes achieved. Factors such as business process alignment with the ERP system, meeting customer and stakeholder needs and reducing recurring and maintenance costs were key to the success of ERP implementation for the Australian SME. In particular, the IT and business strategy alignment with a customer focus and flexible reporting features of ERP systems has resulted in business agility.

  8. Information management challenges of the EOS Data and Information System

    Science.gov (United States)

    Mcdonald, Kenneth R.; Blake, Deborah J.

    1991-01-01

    An overview of the current information management concepts that are embodied in the plans for the Earth Observing System Data and Information System (EOSDIS) is presented, and some of the technology development and application areas that are envisioned to be particularly challenging are introduced. The Information Management System (IMS) is the EOSDIS element that provides the primary interface between the science users and the data products and services of EOSDIS. The goals of IMS are to define a clear and complete set of functional requirements and to apply innovative methods and technologies to satisfy them. The information management functions are described in detail, and some applicable technolgies are discussed. Some of the general issues affecting the successful development and operation of the information management element are addressed.

  9. Progress and challenges to the global waste management system.

    Science.gov (United States)

    Singh, Jagdeep; Laurenti, Rafael; Sinha, Rajib; Frostell, Björn

    2014-09-01

    Rapid economic growth, urbanization and increasing population have caused (materially intensive) resource consumption to increase, and consequently the release of large amounts of waste to the environment. From a global perspective, current waste and resource management lacks a holistic approach covering the whole chain of product design, raw material extraction, production, consumption, recycling and waste management. In this article, progress and different sustainability challenges facing the global waste management system are presented and discussed. The study leads to the conclusion that the current, rather isolated efforts, in different systems for waste management, waste reduction and resource management are indeed not sufficient in a long term sustainability perspective. In the future, to manage resources and wastes sustainably, waste management requires a more systems-oriented approach that addresses the root causes for the problems. A specific issue to address is the development of improved feedback information (statistics) on how waste generation is linked to consumption. © The Author(s) 2014.

  10. Security Challenges in Smart-Grid Metering and Control Systems

    Directory of Open Access Journals (Sweden)

    Xinxin Fan

    2013-07-01

    Full Text Available The smart grid is a next-generation power system that is increasingly attracting the attention of government, industry, and academia. It is an upgraded electricity network that depends on two-way digital communications between supplier and consumer that in turn give support to intelligent metering and monitoring systems. Considering that energy utilities play an increasingly important role in our daily life, smart-grid technology introduces new security challenges that must be addressed. Deploying a smart grid without adequate security might result in serious consequences such as grid instability, utility fraud, and loss of user information and energy-consumption data. Due to the heterogeneous communication architecture of smart grids, it is quite a challenge to design sophisticated and robust security mechanisms that can be easily deployed to protect communications among different layers of the smart grid-infrastructure. In this article, we focus on the communication-security aspect of a smart-grid metering and control system from the perspective of cryptographic techniques, and we discuss different mechanisms to enhance cybersecurity of the emerging smart grid. We aim to provide a comprehensive vulnerability analysis as well as novel insights on the cybersecurity of a smart grid.

  11. Immigrants and health system challenges to TB control in Oman

    Directory of Open Access Journals (Sweden)

    Fochsen Grethe

    2010-07-01

    Full Text Available Abstract Background During the past three decades, Oman has made significant progress in controlling TB within it's borders. However, the national TB control program elimination target has yet to be reached. This study aims to explore the perceived roles played by the immigrant population and the private health sector in relation to TB control in Oman. Methods We conducted seventeen interviews with different health care providers. The verbatim transcripts were processed using content analysis. Results Three main themes emerged. Firstly the threat of repatriation faced by underprivileged expatriates, secondly the criticized and forgotten private health sector as a key player and thirdly the user and provider barriers faced by Omani patients in the Omani public health system. Conclusions The study has identified some of the challenges and barriers to TB control in Oman. These challenges are mainly related to unintended negative consequences arising from the current repatriation policy of immigrants and to and the lack of involvement of the private sector in TB control. TB control strategies designed to address these challenges are needed, for Oman to reach its TB elimination targets.

  12. New Advances and Challenges of Fall Detection Systems: A Survey

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2018-03-01

    Full Text Available Falling, as one of the main harm threats to the elderly, has drawn researchers’ attentions and has always been one of the most valuable research topics in the daily health-care for the elderly in last two decades. Before 2014, several researchers reviewed the development of fall detection, presented issues and challenges, and navigated the direction for the study in the future. With smart sensors and Internet of Things (IoT developing rapidly, this field has made great progress. However, there is a lack of a review and discussion on novel sensors, technologies and algorithms introduced and employed from 2014, as well as the emerging challenges and new issues. To bridge this gap, we present an overview of fall detection research and discuss the core research questions on this topic. A total of 6830 related documents were collected and analyzed based on the key words. Among these documents, the twenty most influential and highly cited articles are selected and discussed profoundly from three perspectives: sensors, algorithms and performance. The findings would assist researchers in understanding current developments and barriers in the systems of fall detection. Although researchers achieve fruitful work and progress, this research domain still confronts challenges on theories and practice. In the near future, the new solutions based on advanced IoT will sustainably urge the development to prevent falling injuries.

  13. Opportunities and challenges for multicriteria assessment of food system sustainability

    Directory of Open Access Journals (Sweden)

    Hugo F. Alrøe

    2016-03-01

    Full Text Available The focus of the Special Feature on "Multicriteria assessment of food system sustainability" is on the complex challenges of making and communicating overall assessments of food systems sustainability based on multiple and varied criteria. Four papers concern the choice and development of appropriate tools for making multicriteria sustainability assessments that handle built-in methodological conflicts and trade-offs between different assessment objectives. They underscore the value of linking diverse methods and tools, or nesting and stepping their deployment, to help build resilience and sustainability. They conclude that there is no one tool, one framework, or one indicator set that is appropriate for the different purposes and contexts of sustainability assessment. The process of creating the assessment framework also emerges as important: if the key stakeholders are not given a responsible and full role in the development of any assessment tool, it is less likely to be fit for their purpose and they are unlikely to take ownership or have confidence in it. Six other papers reflect on more fundamental considerations of how assessments are based in different scientific perspectives and on the role of values, motivation, and trust in relation to assessments in the development of more sustainable food systems. They recommend a radical break with the tradition of conducting multicriteria assessment from one hegemonic perspective to considering multiple perspectives. Collectively the contributions to this Special Feature identify three main challenges for improved multicriteria assessment of food system sustainability: (i how to balance different types of knowledge to avoid that the most well-known, precise, or easiest to measure dimensions of sustainability gets the most weight; (ii how to expose the values in assessment tools and choices to allow evaluation of how they relate to the ethical principles of sustainable food systems, to societal

  14. The Modern Hearing Aid – an Extreme System Integration Challenge

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    (Application Specific Integrated Circuit) to produce a competitive advantage in terms of size and features. This presentation will give a brief insight into the hearing aid market and industry and a brief view of the historic development of hearing aids. The system integration challenge will be illustrated......People with reduced hearing generally want to hide this disability and thus the size of hearing aids is constantly decreasing in the effort to make them virtually invisible. However, as for all other modern electrical devices more and more features are constantly added to hearing aids driven...

  15. Health recommender systems: concepts, requirements, technical basics and challenges.

    Science.gov (United States)

    Wiesner, Martin; Pfeifer, Daniel

    2014-03-03

    During the last decades huge amounts of data have been collected in clinical databases representing patients' health states (e.g., as laboratory results, treatment plans, medical reports). Hence, digital information available for patient-oriented decision making has increased drastically but is often scattered across different sites. As as solution, personal health record systems (PHRS) are meant to centralize an individual's health data and to allow access for the owner as well as for authorized health professionals. Yet, expert-oriented language, complex interrelations of medical facts and information overload in general pose major obstacles for patients to understand their own record and to draw adequate conclusions. In this context, recommender systems may supply patients with additional laymen-friendly information helping to better comprehend their health status as represented by their record. However, such systems must be adapted to cope with the specific requirements in the health domain in order to deliver highly relevant information for patients. They are referred to as health recommender systems (HRS). In this article we give an introduction to health recommender systems and explain why they are a useful enhancement to PHR solutions. Basic concepts and scenarios are discussed and a first implementation is presented. In addition, we outline an evaluation approach for such a system, which is supported by medical experts. The construction of a test collection for case-related recommendations is described. Finally, challenges and open issues are discussed.

  16. Health Recommender Systems: Concepts, Requirements, Technical Basics and Challenges

    Directory of Open Access Journals (Sweden)

    Martin Wiesner

    2014-03-01

    Full Text Available During the last decades huge amounts of data have been collected in clinical databases representing patients’ health states (e.g., as laboratory results, treatment plans, medical reports. Hence, digital information available for patient-oriented decision making has increased drastically but is often scattered across different sites. As as solution, personal health record systems (PHRS are meant to centralize an individual’s health data and to allow access for the owner as well as for authorized health professionals. Yet, expert-oriented language, complex interrelations of medical facts and information overload in general pose major obstacles for patients to understand their own record and to draw adequate conclusions. In this context, recommender systems may supply patients with additional laymen-friendly information helping to better comprehend their health status as represented by their record. However, such systems must be adapted to cope with the specific requirements in the health domain in order to deliver highly relevant information for patients. They are referred to as health recommender systems (HRS. In this article we give an introduction to health recommender systems and explain why they are a useful enhancement to PHR solutions. Basic concepts and scenarios are discussed and a first implementation is presented. In addition, we outline an evaluation approach for such a system, which is supported by medical experts. The construction of a test collection for case-related recommendations is described. Finally, challenges and open issues are discussed.

  17. Thermostability of biological systems: fundamentals, challenges, and quantification.

    Science.gov (United States)

    He, Xiaoming

    2011-01-01

    This review examines the fundamentals and challenges in engineering/understanding the thermostability of biological systems over a wide temperature range (from the cryogenic to hyperthermic regimen). Applications of the bio-thermostability engineering to either destroy unwanted or stabilize useful biologicals for the treatment of diseases in modern medicine are first introduced. Studies on the biological responses to cryogenic and hyperthermic temperatures for the various applications are reviewed to understand the mechanism of thermal (both cryo and hyperthermic) injury and its quantification at the molecular, cellular and tissue/organ levels. Methods for quantifying the thermophysical processes of the various applications are then summarized accounting for the effect of blood perfusion, metabolism, water transport across cell plasma membrane, and phase transition (both equilibrium and non-equilibrium such as ice formation and glass transition) of water. The review concludes with a summary of the status quo and future perspectives in engineering the thermostability of biological systems.

  18. Nonviral Delivery Systems For Cancer Gene Therapy: Strategies And Challenges.

    Science.gov (United States)

    Shim, Gayong; Kim, Dongyoon; Le, Quoc-Viet; Park, Gyu Thae; Kwon, Taekhyun; Oh, Yu-Kyoung

    2018-01-19

    Gene therapy has been receiving widespread attention due to its unique advantage in regulating the expression of specific target genes. In the field of cancer gene therapy, modulation of gene expression has been shown to decrease oncogenic factors in cancer cells or increase immune responses against cancer. Due to the macromolecular size and highly negative physicochemical features of plasmid DNA, efficient delivery systems are an essential ingredient for successful gene therapy. To date, a variety of nanostructures and materials have been studied as nonviral gene delivery systems. In this review, we will cover nonviral delivery strategies for cancer gene therapy, with a focus on target cancer genes and delivery materials. Moreover, we will address current challenges and perspectives for nonviral delivery-based cancer gene therapeutics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Front-end electronics and trigger systems - status and challenges

    International Nuclear Information System (INIS)

    Spieler, Helmuth G; Spieler, Helmuth G

    2007-01-01

    The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not provide the required electronic noise at lower power, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

  20. Challenges facing air management for fuel cell systems

    Energy Technology Data Exchange (ETDEWEB)

    Davis, P.B. [Department of Energy (United States); Sutton, R. [Argonne National Lab. (United States); Wagner, F.W. [Energetics Incorporated (United States)

    2000-07-01

    The U.S. Department of Energy (DOE) and the U.S. automotive industry are working cooperatively under the auspices of the Partnership for a New Generation of Vehicles (PNGV) to develop a six-passenger automobile that can achieve up to 80 mpg. while meeting customer needs and all safety and emission requirements. These partners are continuing to invest heavily in the research and development of polymer electrolyte membrane (PEM) fuel cells as a clean and efficient energy conversion system for the PNGV. A critical challenge facing fuel cell systems for the PNGV is the development of efficient, compact, cost-effective air management systems. The U.S. Department of Energy has been exploring several compressor/expander options for pressurized fuel cell systems, including scroll, toroidal intersecting vane, turbine, twin screw, and piston technologies. Each of these technologies has strengths and weaknesses regarding efficiency, pressure ratio over turndown, size and weight, and cost. This paper will present data from the U.S. Department of Energy's research and development efforts on air management systems and will discusses recent program developments resulting from an independent peer review evaluation. (author)

  1. Fourth Data Challenge for the ALICE data acquisition system

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ALICE experiment will study quark-gluon plasma using beams of heavy ions, such as those of lead. The particles in the beams will collide thousands of times per second in the detector and each collision will generate an event containing thousands of charged particles. Every second, the characteristics of tens of thousands of particles will have to be recorded. Thus, to be effective, the data acquisition system (DAQ) must meet extremely strict performance criteria. To this end, the ALICE Data Challenges entail step-by-step testing of the DAQ with existing equipment that is sufficiently close to the final equipment to provide a reliable indication of performance. During the fourth challenge, in 2002, a data acquisition rate of 1800 megabytes per second was achieved by using some thirty parallel-linked PCs running the specially developed DATE software. During the final week of tests in December 2002, the team also tested the Storage Tek linear magnetic tape drives. Their bandwidth is 30 megabytes per second a...

  2. Digital health and the challenge of health systems transformation

    Science.gov (United States)

    Gagnon, Marie-Pierre; Fortin, Jean-Paul

    2017-01-01

    Information and communication technologies have transformed all sectors of society. The health sector is no exception to this trend. In light of “digital health”, we see multiplying numbers of web platforms and mobile health applications, often brought by new unconventional players who produce and offer services in non-linear and non-hierarchal ways, this by multiplying access points to services for people. Some speak of a “uberization” of healthcare. New realities and challenges have emerged from this paradigm, which question the abilities of health systems to cope with new business and economic models, governance of data and regulation. Countries must provide adequate responses so that digital health, based increasingly on disruptive technologies, can benefit for all. PMID:28894741

  3. Urban underground logistics system in China: Opportunities or challenges?

    Directory of Open Access Journals (Sweden)

    Zhilong Chen

    2017-09-01

    Full Text Available An urban underground logistics system (ULS is one important means of solving urban traffic problems that has unique advantages. Freight transportation in China requires a new transportation mode. Therefore, ULS has garnered increasing attention. However, to date, few scholars and practitioners have investigated ULS in China. Although ULS shows good development opportunities, it also faces great challenges. Based on the Macro-environment and situation analysis (PEST-SWOT model, which is a strategic analysis method that combines both SWOT and PEST to effectively identify advantages, disadvantages, opportunities and threats, this paper first uses PEST to analyze the macro-environment of ULS in China and identify its internal factors (i.e., advantages and disadvantages and external factors (i.e., opportunities and threats. Next, based on the SWOT framework, this paper proposes several development strategies and recommendations that provide a comprehensive and novel perspective to the study of ULS in China.

  4. Digital health and the challenge of health systems transformation.

    Science.gov (United States)

    Alami, Hassane; Gagnon, Marie-Pierre; Fortin, Jean-Paul

    2017-01-01

    Information and communication technologies have transformed all sectors of society. The health sector is no exception to this trend. In light of "digital health", we see multiplying numbers of web platforms and mobile health applications, often brought by new unconventional players who produce and offer services in non-linear and non-hierarchal ways, this by multiplying access points to services for people. Some speak of a "uberization" of healthcare. New realities and challenges have emerged from this paradigm, which question the abilities of health systems to cope with new business and economic models, governance of data and regulation. Countries must provide adequate responses so that digital health, based increasingly on disruptive technologies, can benefit for all.

  5. Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation.

    Science.gov (United States)

    Paldi, Andras

    2018-01-01

    The cells of a multicellular organism are derived from a single zygote and genetically identical. Yet, they are phenotypically very different. This difference is the result of a process commonly called cell differentiation. How the phenotypic diversity emerges during ontogenesis or regeneration is a central and intensely studied but still unresolved issue in biology. Cell biology is facing conceptual challenges that are frequently confused with methodological difficulties. How to define a cell type? What stability or change means in the context of cell differentiation and how to deal with the ubiquitous molecular variations seen in the living cells? What are the driving forces of the change? We propose to reframe the problem of cell differentiation in a systemic way by incorporating different theoretical approaches. The new conceptual framework is able to capture the insights made at different levels of cellular organization and considered previously as contradictory. It also provides a formal strategy for further experimental studies.

  6. Integrating Photovoltaic Systems in Power System: Power Quality Impacts and Optimal Planning Challenges

    Directory of Open Access Journals (Sweden)

    Aida Fazliana Abdul Kadir

    2014-01-01

    Full Text Available This paper is an overview of some of the main issues in photovoltaic based distributed generation (PVDG. A discussion of the harmonic distortion produced by PVDG units is presented. The maximum permissible penetration level of PVDG in distribution system is also considered. The general procedures of optimal planning for PVDG placement and sizing are also explained in this paper. The result of this review shows that there are different challenges for integrating PVDG in the power systems. One of these challenges is integrated system reliability whereas the amount of power produced by renewable energy source is consistent. Thus, the high penetration of PVDG into grid can decrease the reliability of the power system network. On the other hand, power quality is considered one of the challenges of PVDG whereas the high penetration of PVDGs can lead to more harmonic propagation into the power system network. In addition to that, voltage fluctuation of the integrated PVDG and reverse power flow are two important challenges to this technology. Finally, protection of power system with integrated PVDG is one of the most critical challenges to this technology as the current protection schemes are designed for unidirectional not bidirectional power flow pattern.

  7. RFIC's challenges for third-generation wireless systems

    Science.gov (United States)

    Boric-Lubecke, Olga; Lin, Jenshan; Gould, Penny; Kermalli, Munawar

    2001-11-01

    Third generation (3G) cellular wireless systems are envisioned to offer low cost, high-capacity mobile communications with data rates of up to 2 Mbit/s, with global roaming and advanced data services. Besides adding mobility to the internet, 3G systems will provide location-based services, as well as personalized information and entertainment. Low cost, high dynamic-range radios, both for base stations (BS) and for mobile stations (MS) are required to enable worldwide deployment of such networks. A receiver's reference sensitivity, intermodulation characteristics, and blocking characteristics, set by a wireless standard, define performance requirements of individual components of a receiver front end. Since base station handles multiple signals from various distances simultaneously, its radio specifications are significantly more demanding than those for mobile devices. While high level of integration has already been achieved for second generation hand-sets using low-cost silicon technologies, the cost and size reduction of base stations still remains a challenge and necessity. While silicon RFIC technology is steadily improving, it is still difficult to achieve noise figure (NF), linearity, and phase noise requirements with presently available devices. This paper will discuss base station specification for 2G (GSM) and 3G (UMTS) systems, as well as the feasibility of implementing base station radios in low-cost silicon processes.

  8. Privacy Management and Networked PPD Systems - Challenges Solutions.

    Science.gov (United States)

    Ruotsalainen, Pekka; Pharow, Peter; Petersen, Francoise

    2015-01-01

    Modern personal portable health devices (PPDs) become increasingly part of a larger, inhomogeneous information system. Information collected by sensors are stored and processed in global clouds. Services are often free of charge, but at the same time service providers' business model is based on the disclosure of users' intimate health information. Health data processed in PPD networks is not regulated by health care specific legislation. In PPD networks, there is no guarantee that stakeholders share same ethical principles with the user. Often service providers have own security and privacy policies and they rarely offer to the user possibilities to define own, or adapt existing privacy policies. This all raises huge ethical and privacy concerns. In this paper, the authors have analyzed privacy challenges in PPD networks from users' viewpoint using system modeling method and propose the principle "Personal Health Data under Personal Control" must generally be accepted at global level. Among possible implementation of this principle, the authors propose encryption, computer understandable privacy policies, and privacy labels or trust based privacy management methods. The latter can be realized using infrastructural trust calculation and monitoring service. A first step is to require the protection of personal health information and the principle proposed being internationally mandatory. This requires both regulatory and standardization activities, and the availability of open and certified software application which all service providers can implement. One of those applications should be the independent Trust verifier.

  9. Graphene and the immune system: Challenges and potentiality.

    Science.gov (United States)

    Orecchioni, Marco; Ménard-Moyon, Cécilia; Delogu, Lucia Gemma; Bianco, Alberto

    2016-10-01

    In the growing area of nanomedicine, graphene-based materials (GBMs) are some of the most recent explored nanomaterials. For the majority of GBM applications in nanomedicine, the immune system plays a fundamental role. It is necessary to well understand the complexity of the interactions between GBMs, the immune cells, and the immune components and how they could be of advantage for novel effective diagnostic and therapeutic approaches. In this review, we aimed at painting the current picture of GBMs in the background of the immune system. The picture we have drawn looks like a cubist image, a sort of Picasso-like portrait looking at the topic from all perspectives: the challenges (due to the potential toxicity) and the potentiality like the conjugation of GBMs to biomolecules to develop advanced nanomedicine tools. In this context, we have described and discussed i) the impact of graphene on immune cells, ii) graphene as immunobiosensor, and iii) antibodies conjugated to graphene for tumor targeting. Thanks to the huge advances on graphene research, it seems realistic to hypothesize in the near future that some graphene immunoconjugates, endowed of defined immune properties, can go through preclinical test and be successfully used in nanomedicine. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Management of systemic lupus erythematosus during pregnancy: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Knight CL

    2017-03-01

    Full Text Available Caroline L Knight, Catherine Nelson-Piercy Division of Women’s Health, Women’s Health Academic Centre, King’s College London and King’s Health Partners, St Thomas’ Hospital, London, UK Abstract: Systemic lupus erythematosus (SLE is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal–neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy. In pregnancy, early referral for hospital-coordinated care, involvement of obstetricians and rheumatologists (and other specialists as required, an individual management plan, regular reviews, and early recognition of flares and complications are all important. Women are at risk of lupus flares, worsening renal impairment, onset of or worsening hypertension, preeclampsia, and/or venous thromboembolism, and miscarriage, intrauterine growth restriction, preterm delivery, and/or neonatal lupus syndrome (congenital heart block or neonatal lupus erythematosus. A cesarean section may be required in certain obstetric contexts (such as urgent preterm delivery for maternal and/or fetal well-being, but vaginal birth should be the aim for the majority of women. Postnatally, an ongoing individual management plan remains important, with neonatal management where necessary and rheumatology follow-up. This article explores the challenges at each stage of pregnancy, discusses the effect of SLE on pregnancy and

  11. Challenges of structural materials for innovative nuclear systems in Europe

    International Nuclear Information System (INIS)

    Serrano, M.; Gomez-Briceno, D.

    2009-01-01

    New fusion and fission reactors for generation IV are envisaged to operate at conditions well above the actual ones for commercial fission reactors. This type of reactor combined a high operation temperature with a high neutron dose and an aggressive coolant, which imply new challenges for structural materials. One of the key issues to assure the safety and feasibility of these new nuclear systems is the selection of the structural materials, especially for in core components. Beside the differences between them, especially the amount of transmutation He in fusion reactors, similar structural materials have been selected. Some of the selected materials are well characterized at least at medium temperatures, as conventional ferritic/martensitic steels, but the qualification for higher temperatures is needed. For other materials, as ODS steels, there is a need for a complete characterization and qualification. In this paper a review of the operating conditions and selected structural materials for generation IV and fusion reactors within Europe is made. The needs for a complete characterization of these candidate materials are identified in terms of high temperature behaviour, radiation damage and coolant compatibility. (author)

  12. Women in Arab countries: challenging the patriarchal system?

    Science.gov (United States)

    Fargues, Philippe

    2005-05-01

    Progress in the empowerment of Arab women was found to be low in a 2002 report. Yet Arab women's status is not reflected in continuing high fertility, which in 2000 had dropped sharply in one generation to 3.4. This paper discusses why fertility decline could nevertheless have taken place in the Arab countries. Islam has not stood in the way of fertility decline, as Iran and Algeria show. From the mid- 1970s to 1980s, subsidised consumption through oil wealth redistribution reduced the cost of children, and social conservatism kept married women out of the labour force, both of which promoted higher fertility. The early stages of fertility decline were mainly due to longer length of education of girls, rising female age at first marriage, e.g. 28 in urban Morocco and 29 in Libya, and entry into the labour force of young, single women. There is also a growing population sub-group of never-married young women. Collapsing oil prices and structural adjustment reduced household resources and became an effective fertility regulation factor. Girls born since the 1950s have not only been educated longer than their mothers, but also their fathers, which increases their authority. These factors, and women's activism and civil and political lobbying for the reform of personal status now underway in a number of Arab countries, could all challenge the patriarchal system.

  13. Identity Management Mismatch Challenges in the Danish Municipality Administration System

    DEFF Research Database (Denmark)

    Andersen, Mads Schaarup; Christensen, Henrik Bærbak

    2010-01-01

    Integrating a COTS product in a company’s product portfolio is appealing from a business perspective but highly challenging from the perspective of the software architecture. In this paper we outline research challenges regarding authorization in the identity management part of the Danish...

  14. Kazakhstan's Environment-Health system, a Big Data challenge

    Science.gov (United States)

    Vitolo, Claudia; Bella Gazdiyeva, Bella; Tucker, Allan; Russell, Andrew; Ali, Maged; Althonayan, Abraham

    2016-04-01

    Kazakhstan has witnessed a remarkable economic development in the past 15 years, becoming an upper-middle-income country. However it is still widely regarded as a developing nation, partially because of its population's low life expectancy which is 5 years below the average in similar economies. The environment is in a rather fragile state, affected by soil, water, air pollution, radioactive contamination and climate change. However, Kazakhstan's government is moving towards clean energy and environmental protection and calling on scientists to help prioritise investments. The British Council-funded "Kazakhstan's Environment-Health Risk Analysis (KEHRA)" project is one of the recently launched initiatives to support Kazakhstan healthier future. The underlying hypothesis of this research is that the above mentioned factors (air/water/soil pollution, etc.) affecting public health almost certainly do not act independently but rather trigger and exacerbate each other. Exploring the environment-health links in a multi-dimensional framework is a typical Big Data problem, in which the volume and variety of the data needed poses technical as well as scientific challenges. In Kazakhstan, the complexities related to managing and analysing Big Data are worsened by a number of obstacles at the data acquisition step: most of the data is not in digital form, spatial and temporal attributes are often ambiguous and the re-use and re-purpose of the information is subject to restrictive licenses and other mechanisms of control. In this work, we document the first steps taken towards building an understanding of the complex environment-health system in Kazakhstan, using interactive visualisation tools to identify and compare hot-spots of pollution and poor health outcomes, Big Data and web technologies to collect, manage and explore available information. In the future, the knowledge acquired will be modelled to develop evidence-based recommendation systems for decision makers in

  15. Challenges of information systems strategy implementation in public hospitals: a South African experience

    CSIR Research Space (South Africa)

    Hwabamungu, B

    2015-05-01

    Full Text Available on this phenomenon in the healthcare sector. Building on previous IS strategizing research we explored the challenges of Information Systems strategy implementation. We then explored the challenges of IS strategy implementation in public hospitals in developing...

  16. NASA Engineering Design Challenges: Environmental Control and Life Support Systems. Water Filtration Challenge. EG-2008-09-134-MSFC

    Science.gov (United States)

    Schneider, Twila, Ed.

    2010-01-01

    This educator guide is organized into seven chapters: (1) Overview; (2) The Design Challenge; (3) Connections to National Curriculum Standards; (4) Preparing to Teach; (5) Classroom Sessions; (6) Opportunities for Extension; and (7) Teacher Resources. Chapter 1 provides information about Environmental Control and Life Support Systems used on NASA…

  17. Nuclear Hybrid Energy Systems: Imperatives, Prospects, and Challenges

    International Nuclear Information System (INIS)

    Aumeier, Steven E.

    2010-01-01

    certainly not new, renewed interest in more tightly coupled energy product plants (such as HES) that meet the objectives outline above have gained additional interest recently, an interest likely sparked by sharpening energy security concerns. Studies have shown that non-nuclear integrated (hybrid) energy systems can have appealing attributes in terms of overall process efficiency, enhanced electric grid stability, renewable energy integration, and economic performance, and lifecycle greenhouse gas emissions. These attributes seem to be sufficiently compelling that several significant commercial investments in fossil-renewable HES are being made in the United States while the U.S. Defense Advanced Research Projects Agency (DARPA) has openly solicited information regarding nuclear energy integration schemes. The challenges of nuclear energy integration include myriad issues associated with the following RD and D areas, or 'platforms': (1) feedstock processing (e.g. bio-feedstock integration with coal, carbon feedstock extraction using nuclear energy); (2) heat/energy management (e.g. advanced heat exchangers, process design); (3) energy storage (e.g. H2 production, liquid fuels synthesis); (4) byproduct management (e.g. CO2 recycle approaches); (5) systems dynamics, integration and control (e.g. process dynamics analyses and optimization, advanced prognostics, diagnostics, variable time scale control and flow sheet optimization).

  18. The promises and challenges of future reactor system developments

    International Nuclear Information System (INIS)

    Kim, S. H.; Chang, M. H.; Kim, H. J.

    2007-01-01

    improved economy when compared to currently the existing plants. The APR 1400 has been developed since 1991 and it is expected that its first commercial operation will be in 2012. In the short term by 2011, the APR-1400 design will be improved from the viewpoints of safety, economics and performance. We are also developing a small integral reactor SMART, which is a promising advanced small and medium-size power category of nuclear reactors. It is an integral type reactor with a sensible mixture of new innovative design features and proven technologies aimed at achieving a highly enhanced safety and improved economics. SMART is purposed for dual applications such as for seawater desalination and electricity generation. Since the SMART technology is technically sound and has sufficient economics, the SMART desalination plant has good prospects of being deployed as a nuclear desalination plant. We are also actively participating in the GEN IV collaboration (GIF: GEN IV International Forum) for a VHTR and a SFR technology development. Through close collaboration with GIF, a proliferation-resistant SFR technology will be developed based on KALIMAER for an effective uranium utilization and waste minimization. Also a high temperature reactor is currently under development to demonstrate a nuclear based hydrogen production technology. Korea is really looking ahead by developing new generation of advanced nuclear reactor systems for a sustainable development, economical benefits, a clean environment and public confidence. In this paper, Korean nuclear reactor technology development program is described together with lessons learned from self-reliance in nuclear reactor technology. In addition, this paper presents the status of the next generation reactor system development program and the future reactor system development program for addressing these challenges

  19. Building a Global Earth Observation System of Systems (GEOSS) and Its Interoperability Challenges

    Science.gov (United States)

    Ryan, B. J.

    2015-12-01

    Launched in 2005 by industrialized nations, the Group on Earth Observations (GEO) began building the Global Earth Observation System of Systems (GEOSS). Consisting of both a policy framework, and an information infrastructure, GEOSS, was intended to link and/or integrate the multitude of Earth observation systems, primarily operated by its Member Countries and Participating Organizations, so that users could more readily benefit from global information assets for a number of society's key environmental issues. It was recognized that having ready access to observations from multiple systems was a prerequisite for both environmental decision-making, as well as economic development. From the very start, it was also recognized that the shear complexity of the Earth's system cannot be captured by any single observation system, and that a federated, interoperable approach was necessary. While this international effort has met with much success, primarily in advancing broad, open data policies and practices, challenges remain. In 2014 (Geneva, Switzerland) and 2015 (Mexico City, Mexico), Ministers from GEO's Member Countries, including the European Commission, came together to assess progress made during the first decade (2005 to 2015), and approve implementation strategies and mechanisms for the second decade (2016 to 2025), respectively. The approved implementation strategies and mechanisms are intended to advance GEOSS development thereby facilitating the increased uptake of Earth observations for informed decision-making. Clearly there are interoperability challenges that are technological in nature, and several will be discussed in this presentation. There are, however, interoperability challenges that can be better characterized as economic, governmental and/or political in nature, and these will be discussed as well. With the emergence of the Sustainable Development Goals (SDGs), the World Conference on Disaster Risk Reduction (WCDRR), and the United Nations

  20. RNAi nanomedicines: challenges and opportunities within the immune system

    International Nuclear Information System (INIS)

    Weinstein, Shiri; Peer, Dan

    2010-01-01

    RNAi, as a novel therapeutic modality, has an enormous potential to bring the era of personalized medicine one step further from notion into reality. However, delivery of RNAi effector molecules into their target tissues and cells remain extremely challenging. Major attempts have been made in recent years to develop sophisticated nanocarriers that could overcome these hurdles. This review will present the recent progress with the challenges and opportunities in this emerging field, focusing mostly on the in vivo applications with special emphasis on the strategies for RNAi delivery into immune cells. (topical review)

  1. Future illumination systems and the climate change challenge

    DEFF Research Database (Denmark)

    Bjarklev, Araceli; Bjarklev, Anders Overgaard

    2010-01-01

    are met in conjunction with situations, where the esthetical design issues are addressed. Finally, our study also points out to the necessity of finding a trans-disciplinary cooperation across sectors to more effectively answer to the climate change challenge, when designing low-carbon technologies...

  2. Editorial: Challenges and solutions in GW calculations for complex systems

    Science.gov (United States)

    Giustino, F.; Umari, P.; Rubio, A.

    2012-09-01

    We report key advances in the area of GW calculations, review the available software implementations and define standardization criteria to render the comparison between GW calculations from different codes meaningful, and identify future major challenges in the area of quasiparticle calculations. This Topical Issue should be a reference point for further developments in the field.

  3. Teacher Perspectives of Challenges within the Norwegian Educational System

    Science.gov (United States)

    Anderson, Sarah K.; Terras, Katherine L.

    2015-01-01

    This research examines teacher perspectives' of educational challenges in Norway. Norway is one of the most well-resourced, prosperous, social welfare states in the world, yet the OECD (2011) recognized students' weak basic skills and insufficient teacher ability in content and pedagogy, along with engagement and imbalanced resources as points for…

  4. The challenge of benchmarking health systems: is ICT innovation capacity more systemic than organizational dependent?

    Science.gov (United States)

    Lapão, Luís Velez

    2015-01-01

    The article by Catan et al. presents a benchmarking exercise comparing Israel and Portugal on the implementation of Information and Communication Technologies in the healthcare sector. Special attention was given to e-Health and m-Health. The authors collected information via a set of interviews with key stakeholders. They compared two different cultures and societies, which have reached slightly different implementation outcomes. Although the comparison is very enlightening, it is also challenging. Benchmarking exercises present a set of challenges, such as the choice of methodologies and the assessment of the impact on organizational strategy. Precise benchmarking methodology is a valid tool for eliciting information about alternatives for improving health systems. However, many beneficial interventions, which benchmark as effective, fail to translate into meaningful healthcare outcomes across contexts. There is a relationship between results and the innovational and competitive environments. Differences in healthcare governance and financing models are well known; but little is known about their impact on Information and Communication Technology implementation. The article by Catan et al. provides interesting clues about this issue. Public systems (such as those of Portugal, UK, Sweden, Spain, etc.) present specific advantages and disadvantages concerning Information and Communication Technology development and implementation. Meanwhile, private systems based fundamentally on insurance packages, (such as Israel, Germany, Netherlands or USA) present a different set of advantages and disadvantages - especially a more open context for innovation. Challenging issues from both the Portuguese and Israeli cases will be addressed. Clearly, more research is needed on both benchmarking methodologies and on ICT implementation strategies.

  5. Challenges in miniaturized automotive long-range lidar system design

    Science.gov (United States)

    Fersch, Thomas; Weigel, Robert; Koelpin, Alexander

    2017-05-01

    This paper discusses the current technical limitations posed on endeavors to miniaturize lidar systems for use in automotive applications and how to possibly extend those limits. The focus is set on long-range scanning direct time of flight LiDAR systems using APD photodetectors. Miniaturization evokes severe problems in ensuring absolute laser safety while maintaining the systems' performance in terms of maximum range, signal-to-noise ratio, detection probability, pixel density, or frame rate. Based on hypothetical but realistic specifications for an exemplary system the complete lidar signal path is calculated. The maximum range of the system is used as a general performance indicator. It is determined with the minimum signal-to-noise ratio required to detect an object. Various system parameters are varied to find their impact on the system's range. The reduction of the laser's pulse width and the right choice for the transimpedance amplifier's amplification have shown to be practicable measures to double the system's range.

  6. Taming Big Data Variety in the Earth Observing System Data and Information System

    Science.gov (United States)

    Lynnes, Christopher; Walter, Jeff

    2015-01-01

    Although the volume of the remote sensing data managed by the Earth Observing System Data and Information System is formidable, an oft-overlooked challenge is the variety of data. The diversity in satellite instruments, science disciplines and user communities drives cost as much or more as the data volume. Several strategies are used to tame this variety: data allocation to distinct centers of expertise; a common metadata repository for discovery, data format standards and conventions; and services that further abstract the variations in data.

  7. Expert Systems: A Challenge for the Reading Profession.

    Science.gov (United States)

    Balajthy, Ernest

    The expert systems are designed to imitate the reasoning of a human expert in a content area field. Designed to be advisors, these software systems combine the content area knowledge and decision-making ability of an expert with the user's understanding and knowledge of particular circumstances. The reading diagnosis system, the RD2P System…

  8. IFRS IN ROMANIAN BANKING SYSTEM. LIMITS AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    Inesa TOFANICA

    2017-07-01

    Full Text Available In our globalized world, accounting has followed the trend and it has imposed comparability norms in order to adjust to everyday economic transactions. The International Financial Reporting Standards are a set of accounting standards developed by a non-profit organization called IASB (International Accounting Standards Board. This set of standards is applied in many countries all over the world, and Romania is one of them. The advantages of IFRS are well known and recognized, but the path of IFRS adoption is not always smooth. This paper aims to present the limits and the challenges encountered by the companies which apply IFRS in their financial reports.

  9. Arctic System Science: Meeting Earth System and Social Impact Challenges through Integrative Approaches and Synthesis

    Science.gov (United States)

    Vorosmarty, C. J.; Hinzman, L. D.; Rawlins, M. A.; Serreze, M. C.; Francis, J. A.; Liljedahl, A. K.; McDonald, K. C.; Piasecki, M.; Rich, R. H.; Holland, M. M.

    2017-12-01

    The Arctic is an integral part of the Earth system where multiple interactions unite its natural and human elements. Recent observations show the Arctic to be experiencing rapid and amplified signatures of global climate change. At the same time, the Arctic system's response to this broader forcing has itself become a central research topic, given its potential role as a critical throttle on future planetary dynamics. Changes are already impacting life systems and economic prosperity and continued change is expected to bear major implications far outside the region. We also have entered an era when environmental management, traditionally local in scope, must confront regional, whole biome, and pan-Arctic biogeophysical challenges. While challenges may appear to operate in isolation, they emerge within the context of an evolving, integrated Arctic system defined by interactions among natural and social sub-systems. Clearly, new efforts aimed at community planning, industrial development, and infrastructure construction must consider this multiplicity of interacting processes. We recently organized an "Arctic System Synthesis Workshop Series" supported by the Arctic Systems Science Program of NSF and devoted to exploring approaches capable of uncovering the systems-level behavior in both the natural and social sciences domains. The series featured two topical meetings. The first identified the sources responsible for extreme climate events in the Arctic. The second focused on multiple "currencies" within the system (i.e., water, energy, carbon, nutrients) and how they interact to produce systems-level behaviors. More than 40 experts participated, drawn from the ranks of Arctic natural and social sciences. We report here on the workshop series consensus report, which identifies a broad array of topics. Principal among these are a consideration of why study the Arctic as a system, as well as an articulation of the major systems-level approaches to support basic as well

  10. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system

    Directory of Open Access Journals (Sweden)

    Elesban Kihuba

    2016-06-01

    Full Text Available Background: Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. Design: We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit framework to analyze the components and standards of a cost accounting system. Results: Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. Conclusion: To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context.

  11. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system

    Science.gov (United States)

    Kihuba, Elesban; Gheorghe, Adrian; Bozzani, Fiammetta; English, Mike; Griffiths, Ulla K.

    2016-01-01

    Background Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. Design We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit) framework to analyze the components and standards of a cost accounting system. Results Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. Conclusion To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context. PMID:27357072

  12. Opportunities and challenges for implementing cost accounting systems in the Kenyan health system.

    Science.gov (United States)

    Kihuba, Elesban; Gheorghe, Adrian; Bozzani, Fiammetta; English, Mike; Griffiths, Ulla K

    2016-01-01

    Low- and middle-income countries need to sustain efficiency and equity in health financing on their way to universal health care coverage. However, systems meant to generate quality economic information are often deficient in such settings. We assessed the feasibility of streamlining cost accounting systems within the Kenyan health sector to illustrate the pragmatic challenges and opportunities. We reviewed policy documents, and conducted field observations and semi-structured interviews with key informants in the health sector. We used an adapted Human, Organization and Technology fit (HOT-fit) framework to analyze the components and standards of a cost accounting system. Among the opportunities for a viable cost accounting system, we identified a supportive broad policy environment, political will, presence of a national data reporting architecture, good implementation experience with electronic medical records systems, and the availability of patient clinical and resource use data. However, several practical issues need to be considered in the design of the system, including the lack of a framework to guide the costing process, the lack of long-term investment, the lack of appropriate incentives for ground-level staff, and a risk of overburdening the current health management information system. To facilitate the implementation of cost accounting into the health sector, the design of any proposed system needs to remain simple and attuned to the local context.

  13. Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS Drug Delivery Systems for in Vitro and in Vivo Applications

    Directory of Open Access Journals (Sweden)

    Ken-Tye Yong

    2012-11-01

    Full Text Available Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

  14. Adaptive Embedded SystemsChallenges of Run-Time Resource Management

    DEFF Research Database (Denmark)

    Understanding and efficiently controlling the dynamic behavior of adaptive embedded systems is a challenging endavor. The challenges come from the often very complicated interplay between the application, the application mapping, and the underlying hardware architecture. With MPSoC, we have...... the technology to design and fabricate dynamically reconfigurable hardware platforms. However, such platforms will pose new challenges to tools and methods to efficiently explore these platforms at run-time. This talk will address some of the challenges of run-time resource management in adaptive embedded...... systems....

  15. Power System Challenge: Synthesis Report for the 7th Clean Energy Ministerial

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-06-01

    The Clean Energy Ministerial's (CEM's) Power System Challenge was established in 2015 to create a shared vision among major economies regarding the pathway to clean, reliable, resilient, and affordable power. Endorsing governments have created core principles and challenge propositions as a framework for government and industry action to support and guide power system transformation. This brochure details the status of the Challenge, how countries are working to meet the Challenge, and the relevant milestones reached by initiatives of the Clean Energy Ministerial.

  16. 'Motor challenge' pilot programme; Motor Challenge Pilotprogramm. Schweizer Teilnahme im SAVE-Programm: pilot actions for motor systems industrial energy use challenge

    Energy Technology Data Exchange (ETDEWEB)

    Nipkow, J.

    2003-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) presents the results of a pilot project associated with the Motor Challenge Programme (MCP) initiated by the European Commission (Transport and Energy Committee). The programme is briefly described, which aims to improve the efficiency of electrical motors used in industrial compressed-air, pump and ventilator systems as well as in comprehensive motor driven systems. Switzerland's participation in this pilot project is examined, which was concluded after a period of two years when the Motor Challenge Programme itself was launched in February 2003. The mechanisms of the programme are described, whereby companies may become involved in the programme either as partners (users of drive systems) or as endorsers (suppliers, planners, etc., of such systems). Experience gained with two companies in Switzerland - a food processing group and a major chemical pulp producer - who participated in the programme is presented. Efficiency potentials of around 3 GWh/a were identified; these represent a high proportion of the estimated total of 18 GWh/a in the overall programme. A follow-up project is proposed that is to provide detailed information and initiate further efficiency projects in order to encourage other companies to participate in the MCP programme.

  17. THE SYSTEMIC RISK BUFFER – A CHALLENGING INSTRUMENT FOR ASSESSING

    Directory of Open Access Journals (Sweden)

    BADEA IRINA - RALUCA

    2015-08-01

    Full Text Available The consequences of the global financial crisis have changed the orientation of the regulators from the micro towards the macroeconomic level, which encompasses the financial system as a whole, with its components as individual financial institutions. Needless to say that there is an inherent risk to which every participant to the market is exposed, the systemic risk. Therefore, this paper aims at presenting systemic risk in a clear manner, paying attention to and highlighting several approaches regarding systemic risk in literature and practice. Moreover, the mechanism of systemic risk transmission points out the channels through which systemic risk spreads and affects the real economy. There is also presented a new component of the macroprudential regulation, i.e. the systemic risk buffer (SRB, which is an important instrument to fight against systemic risk along with the other buffers stipulated in the Basel III standards. Hence, the subject dealt in this paper represents a realistic outlook upon the situation of the financial system at the moment, in its struggle to forecast a potential systemic threat and the instruments needed to counteract it in order to diminish its negative effects. In the last part of the paper there is presented evidence from a few countries that started to implement the SRB and G-SII or O-SII buffers or are phased for implementation to the extent of 2019. Tracking the vulnerabilities of the system as a whole, of each of its components and the tranmission channels of systemic risk should be the first step to make before taking any measures against a monetary or financial phenomenon.

  18. The Challenges of Basel III for Romanian Banking System

    OpenAIRE

    Anca Elena NUCU

    2011-01-01

    Basel III represents a fundamental review of the regulatory and supervision framework of the banking industry in the future, the aim being to strengthen the stability of the financial system. The purpose of this paper is to analyze the impact of Basel III introduction upon the banking system at European level, respectively, upon the Romanian banking system. If at European level it is estimated a substantial deficit in capital and liquidity, with major impact on profitability indicators, the i...

  19. Emerging nuclear energy systems: Economic challenge: Revision 1

    International Nuclear Information System (INIS)

    Nuckolls, J.H.

    1986-01-01

    Future nuclear energy systems may achieve substantially lower energy costs than those of existing fossil energy systems and comparable capital costs. Such low cost nuclear energy would provide a strong economic incentive to minimize the use of fossil fuels. If these low cost nuclear energy systems emerge in the next few decades, 21st century civilization may be able to avert potentially disastrous CO 2 induced global climate changes. 12 refs., 1 fig

  20. Big Data challenges and solutions in building the Global Earth Observation System of Systems (GEOSS)

    Science.gov (United States)

    Mazzetti, Paolo; Nativi, Stefano; Santoro, Mattia; Boldrini, Enrico

    2014-05-01

    The Group on Earth Observation (GEO) is a voluntary partnership of governments and international organizations launched in response to calls for action by the 2002 World Summit on Sustainable Development and by the G8 (Group of Eight) leading industrialized countries. These high-level meetings recognized that international collaboration is essential for exploiting the growing potential of Earth observations to support decision making in an increasingly complex and environmentally stressed world. To this aim is constructing the Global Earth Observation System of Systems (GEOSS) on the basis of a 10-Year Implementation Plan for the period 2005 to 2015 when it will become operational. As a large-scale integrated system handling large datasets as those provided by Earth Observation, GEOSS needs to face several challenges related to big data handling and big data infrastructures management. Referring to the traditional multiple Vs characteristics of Big Data (volume, variety, velocity, veracity and visualization) it is evident how most of them can be found in data handled by GEOSS. In particular, concerning Volume, Earth Observation already generates a large amount of data which can be estimated in the range of Petabytes (1015 bytes), with Exabytes (1018) already targeted. Moreover, the challenge is related not only to the data size, but also to the large amount of datasets (not necessarily having a big size) that systems need to manage. Variety is the other main challenge since datasets coming from different sensors, processed for different use-cases are published with highly heterogeneous metadata and data models, through different service interfaces. Innovative multidisciplinary applications need to access and use those datasets in a harmonized way. Moreover Earth Observation data are growing in size and variety at an exceptionally fast rate and new technologies and applications, including crowdsourcing, will even increase data volume and variety in the next future

  1. Grand Challenges in Space Technology: Distributed Satellite Systems

    National Research Council Canada - National Science Library

    Miller, David

    2001-01-01

    The MITIAFRL Distributed Satellite Systems program examines the motivation, analysis and development of technology associated with the distribution of assets and functionality over a number of cooperating satellites...

  2. Greenlandic water and sanitation systems-identifying system constellation and challenges

    DEFF Research Database (Denmark)

    Hendriksen, Kåre; Hoffmann, Birgitte

    2017-01-01

    " (United Nations 2015). This obviously raises the question of how this can be achieved considering the very different conditions and cultures around the globe. This article presents the Greenlandic context and elucidates the current Greenland water supply system and wastewater management system from......A good water supply and wastewater management is essential for a local sustainable community development. This is emphasized in the new global goals of the UN Sustainable Development, where the sixth objective is to: "Ensure availability and sustainable management of water and sanitation for all...... a socio-technical approach, focusing on the geographic, climatic and cultural challenges. The article identifies a diverse set of system constellations in different parts of Greenland and concludes with a discussion of health and quality of life implications....

  3. Decadel climate prediction: challenges and opportunities

    International Nuclear Information System (INIS)

    Hurrell, J W

    2008-01-01

    The scientific understanding of climate change is now sufficiently clear to show that climate change from global warming is already upon us, and the rate of change as projected exceeds anything seen in nature in the past 10,000 years. Uncertainties remain, however, especially regarding how climate will change at regional and local scales where the signal of natural variability is large. Addressing many of these uncertainties will require a movement toward high resolution climate system predictions, with a blurring of the distinction between shorter-term predictions and longer-term climate projections. The key is the realization that climate system predictions, regardless of timescale, will require initialization of coupled general circulation models with best estimates of the current observed state of the atmosphere, oceans, cryosphere, and land surface. Formidable challenges exist: for instance, what is the best method of initialization given imperfect observations and systematic errors in models? What effect does initialization have on climate predictions? What predictions should be attempted, and how would they be verified? Despite such challenges, the unrealized predictability that resides in slowly evolving phenomena, such as ocean current systems, is of paramount importance for society to plan and adapt for the next few decades. Moreover, initialized climate predictions will require stronger collaboration with shared knowledge, infrastructure and technical capabilities among those in the weather and climate prediction communities. The potential benefits include improved understanding and predictions on all time scales

  4. Child human trafficking victims: challenges for the child welfare system.

    Science.gov (United States)

    Fong, Rowena; Berger Cardoso, Jodi

    2010-08-01

    Since the passing of the Victims of Trafficking and Violence Protection Act in 2000 and its reauthorization by President George Bush in 2008, federal, state and community efforts in identifying and providing services for victims of human trafficking have significantly improved. However, most of the research and resources for trafficking victims have been directed towards adults rather than children. Researchers agree that there is a growing number of sexually exploited and trafficked children in the United States yet few programs emphasize the unique experiences and special needs of this population. This article examines commercial sexual exploitation of children; differentiates the needs and problems between child prostitution and victims of human trafficking; reviews and critiques current treatment practices; and summarizes challenges and successes in working with child victims of human trafficking, offering practice and policy recommendations. Published by Elsevier Ltd.

  5. Hidden Challenges to Education Systems in Transition Economies.

    Science.gov (United States)

    Berryman, Sue E.

    This book, published by the World Bank, sounds the alarm for education in Europe and Central Asia (ECA). It describes how the transition from communism to free-market economies has left many countries' educational systems in disarray. At the start of transition, ECA education systems had solved problems that plagued other regions of the world,…

  6. Accelerating cooperative systems' development through the Grand Cooperative Driving challenge

    NARCIS (Netherlands)

    Vonk Noordegraaf, D.; Malone, K.M.; Katwijk, R. van; Gerrits, A.

    2009-01-01

    Cooperative driving systems comprise an important research area. They are considered a promising solution for reducing traffic congestion, reducing environmental impact and improving traffic safety and driver comfort. The key to these systems is the communication and interaction between vehicles and

  7. Challenging obduracy : How local communities transform the energy system

    NARCIS (Netherlands)

    Van Der Schoor, Tineke; Van Lente, Harro; Scholtens, Bert; Peine, Alex

    2016-01-01

    The transformation from the current energy system to a decentralized renewable energy system requires the transformation of communities into energy neutral or even energy producing communities. Increasingly, citizens become 'prosumers' and pool their resources to start a local energy initiative. In

  8. Activity theory as a challenge to systems design

    DEFF Research Database (Denmark)

    Bødker, Susanne

    1991-01-01

    This paper suggests an improvement of the theoretical foundation of information systems research of the 1990s. This foundation is found in human activity theory. The paper deals with how human activity theory can help systems design change, theoretically and practically. Applying activity theory...

  9. An integrated drug prescription and distribution system: challenges and opportunities.

    Science.gov (United States)

    Lanssiers, R; Everaert, E; De Win, M; Van De Velde, R; De Clercq, H

    2002-01-01

    Using the hospital's drug prescription and distribution system as a guide, benefits and drawbacks of a medical activity management system that is tightly integrated with the supply chain management of a hospital will be discussed from the point of view of various participating healthcare actors.

  10. Green certificate system for heating - principal and practical challenges

    International Nuclear Information System (INIS)

    Eldegard, Tom

    2002-01-01

    A certificate system with an obligation to buying is a very relevant instrument in energy policy in order to stimulate the implementation of new renewable energy sources. This solution is widely supported; it is being institutionalized in many countries, especially in Europe and in the electricity sector, and the heating sector is soon to follow. This report discusses the broad lines of a possible green certificate system for the heating sector in Norway and concludes that it is might well be linked with a similar system for the electricity sector. For Norway, an isolated certificate system for the electricity sector would not be cost-effective. This is because this system would emphasize relatively expensive renewable electric energy rather than utilizing the large potential for replacing the electric heating of buildings with much cheaper renewable heat

  11. Development of tsunami early warning systems and future challenges

    Directory of Open Access Journals (Sweden)

    J. Wächter

    2012-06-01

    Full Text Available Fostered by and embedded in the general development of information and communications technology (ICT, the evolution of tsunami warning systems (TWS shows a significant development from seismic-centred to multi-sensor system architectures using additional sensors (e.g. tide gauges and buoys for the detection of tsunami waves in the ocean.

    Currently, the beginning implementation of regional tsunami warning infrastructures indicates a new phase in the development of TWS. A new generation of TWS should not only be able to realise multi-sensor monitoring for tsunami detection. Moreover, these systems have to be capable to form a collaborative communication infrastructure of distributed tsunami warning systems in order to implement regional, ocean-wide monitoring and warning strategies.

    In the context of the development of the German Indonesian Tsunami Early Warning System (GITEWS and in the EU-funded FP6 project Distant Early Warning System (DEWS, a service platform for both sensor integration and warning dissemination has been newly developed and demonstrated. In particular, standards of the Open Geospatial Consortium (OGC and the Organization for the Advancement of Structured Information Standards (OASIS have been successfully incorporated.

    In the FP7 project Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC, new developments in ICT (e.g. complex event processing (CEP and event-driven architecture (EDA are used to extend the existing platform to realise a component-based technology framework for building distributed tsunami warning systems.

  12. The LHCb Silicon Tracker - Control system specific tools and challenges

    CERN Document Server

    Adeva, G; Esperante Pereira, D; Gallas, A; Pazos Alvarez, A; Perez Trigo, E; Rodriguez Perez, P; Saborido, J; Amhis, Y; Bay, A; Blanc, F; Bressieux, J; Conti, G; Dupertuis, F; Fave, V; Frei, R; Gauvin, N; Haefeli, G; Keune, A; Luisier, J; Marki, R; Muresan, R; Nakada, T; Needham, M; Knecht, M; Schneider, O; Tran, M; Anderson, J; Buechler, A; Bursche, A; Chiapolini, N; De Cian, M; Elsasser, C; Salzmann, C; Saornil Gamarra, S; Steiner, S; Steinkamp, O; Straumann, U; van Tilburg, J; Tobin, M; Vollhardt, A; Aquines Gutierrez, O; Bauer, C; Britsch, M; Maciuc, F; Schmelling, M; Voss, H; Iakovenko, V; Okhrimenko, O; Pugatch, V

    2014-01-01

    The Experiment Control System (ECS) of the LHCb Silicon Tracker sub-detectors is built on the integrated LHCb ECS framework. Although all LHCb sub-detectors use the same framework and follow the same guidelines, the Silicon Tracker control system uses some interesting additional features in terms of operation and monitoring. The main details are described in this document. Since its design, the Silicon Tracker control system has been continuously evolving in a quite disorganized way. Some major maintenance activities are required to be able to keep improving. A description of those activities can also be found here.

  13. The Challenges of Basel III for Romanian Banking System

    Directory of Open Access Journals (Sweden)

    Anca Elena NUCU

    2011-12-01

    Full Text Available Basel III represents a fundamental review of the regulatory and supervision framework of the banking industry in the future, the aim being to strengthen the stability of the financial system. The purpose of this paper is to analyze the impact of Basel III introduction upon the banking system at European level, respectively, upon the Romanian banking system. If at European level it is estimated a substantial deficit in capital and liquidity, with major impact on profitability indicators, the impact of Basel III upon banking system in Romania is considered to be limited. The measures which credit institutions could take to mitigate the impact of alignment with the new standards are business model adjustment and balance sheet restructuring.

  14. Systemic inflammatory responses following welding inhalation challenge test

    Directory of Open Access Journals (Sweden)

    Paula Kauppi

    2015-01-01

    Conclusions: Exposure to MS and SS welding fume resulted in a mild systemic inflammatory response. The particle concentration from the breathing zones correlated with the measurements inside the welding face shields.

  15. H4: A challenging system for natural orbital functional approximations

    International Nuclear Information System (INIS)

    Ramos-Cordoba, Eloy; Lopez, Xabier; Piris, Mario; Matito, Eduard

    2015-01-01

    The correct description of nondynamic correlation by electronic structure methods not belonging to the multireference family is a challenging issue. The transition of D 2h to D 4h symmetry in H 4 molecule is among the most simple archetypal examples to illustrate the consequences of missing nondynamic correlation effects. The resurgence of interest in density matrix functional methods has brought several new methods including the family of Piris Natural Orbital Functionals (PNOF). In this work, we compare PNOF5 and PNOF6, which include nondynamic electron correlation effects to some extent, with other standard ab initio methods in the H 4 D 4h /D 2h potential energy surface (PES). Thus far, the wrongful behavior of single-reference methods at the D 2h –D 4h transition of H 4 has been attributed to wrong account of nondynamic correlation effects, whereas in geminal-based approaches, it has been assigned to a wrong coupling of spins and the localized nature of the orbitals. We will show that actually interpair nondynamic correlation is the key to a cusp-free qualitatively correct description of H 4 PES. By introducing interpair nondynamic correlation, PNOF6 is shown to avoid cusps and provide the correct smooth PES features at distances close to the equilibrium, total and local spin properties along with the correct electron delocalization, as reflected by natural orbitals and multicenter delocalization indices

  16. H4: A challenging system for natural orbital functional approximations

    Science.gov (United States)

    Ramos-Cordoba, Eloy; Lopez, Xabier; Piris, Mario; Matito, Eduard

    2015-10-01

    The correct description of nondynamic correlation by electronic structure methods not belonging to the multireference family is a challenging issue. The transition of D2h to D4h symmetry in H4 molecule is among the most simple archetypal examples to illustrate the consequences of missing nondynamic correlation effects. The resurgence of interest in density matrix functional methods has brought several new methods including the family of Piris Natural Orbital Functionals (PNOF). In this work, we compare PNOF5 and PNOF6, which include nondynamic electron correlation effects to some extent, with other standard ab initio methods in the H4 D4h/D2h potential energy surface (PES). Thus far, the wrongful behavior of single-reference methods at the D2h-D4h transition of H4 has been attributed to wrong account of nondynamic correlation effects, whereas in geminal-based approaches, it has been assigned to a wrong coupling of spins and the localized nature of the orbitals. We will show that actually interpair nondynamic correlation is the key to a cusp-free qualitatively correct description of H4 PES. By introducing interpair nondynamic correlation, PNOF6 is shown to avoid cusps and provide the correct smooth PES features at distances close to the equilibrium, total and local spin properties along with the correct electron delocalization, as reflected by natural orbitals and multicenter delocalization indices.

  17. Challenges in Modeling the Sun-Earth System

    Science.gov (United States)

    Spann, James

    2004-01-01

    The transfer of mass, energy and momentum through the coupled Sun-Earth system spans a wide range of scales in time and space. While profound advances have been made in modeling isolated regions of the Sun-Earth system, minimal progress has been achieved in modeling the end-to-end system. Currently, end-to-end modeling of the Sun-Earth system is a major goal of the National Space Weather and NASA Living With a Star (LWS) programs. The uncertainty in the underlying physics responsible for coupling contiguous regions of the Sun-Earth system is recognized as a significant barrier to progress. Our limited understanding of the underlying coupling physics is illustrated by the following example questions: how does the propagation of a typical CME/solar flare influence the measured properties of the solar wind at 1 AU? How does the solar wind compel the dynamic response of the Earth's magnetosphere? How is variability in the ionosphere-thermosphere system coupled to magnetospheric variations? Why do these and related important questions remain unanswered? What are the primary problems that need to be resolved to enable significant progress in comprehensive modeling of the Sun-Earth system? Which model/technique improvements are required and what new data coverage is required to enable full model advances? This poster opens the discussion for how these and other important questions can be addressed. A workshop scheduled for October 8-22, 2004 in Huntsville, Alabama, will be a forum for identifying ana exploring promising new directions and approaches for characterizing and understanding the system. To focus the discussion, the workshop will emphasize the genesis, evolution, propagation and interaction of high-speed solar wind streamers or CME/flares with geospace and the subsequent response of geospace from its outer reaches in the magnetosphere to the lower edge of the ionosphere-mesosphere-thermosphere. Particular emphasis will be placed on modeling the coupling aspects

  18. Challenges and Opportunities of Implementing District-based Health Information System in Ethiopia

    DEFF Research Database (Denmark)

    Mengiste, Shegaw Anagaw

    2005-01-01

    This paper has analyzed the challenges of sustainability and scalability of HIS. The empirical analysis was conducted in a backward and disadvantaged region of Ethiopia. An ongoing process of HISP (Health Information System Program) was addressed and the main challenges in the implementation...... of sustainable and scalable district-based health information system in the context of Primary Health Care (PHC) sector in Ethiopia were identified. Human resource, infrastructure, and HIS related problems are the main challenges hindering the implementation of sustainable and scalable district-based health...... information systems in the region....

  19. The unique safety challenges of space reactor systems

    International Nuclear Information System (INIS)

    Lanes, S.J.; Marshall, A.C.

    1991-01-01

    Compact reactor systems can provide high levels of power for extended periods in space environments. Their relatively low mass and their ability to operate independently of their proximity to the sun make reactor power systems high desirable for many civilian and military space missions. The US Department of Energy is developing reactor system technologies to provide electrical power for space applications. In addition, reactors are now being considered to provide thermal power to a hydrogen propellant for nuclear thermal rocketry. Space reactor safety issues differ from commercial reactor issues, in some areas, because of very different operating requirements and environments. Accidents similar to those postulated for commercial reactors must be considered for space reactors during their operational phase. Safety strategies will need to be established that account for the consequences of the loss of essential power

  20. Web Content Management Systems: An Analysis of Forensic Investigatory Challenges.

    Science.gov (United States)

    Horsman, Graeme

    2018-02-26

    With an increase in the creation and maintenance of personal websites, web content management systems are now frequently utilized. Such systems offer a low cost and simple solution for those seeking to develop an online presence, and subsequently, a platform from which reported defamatory content, abuse, and copyright infringement has been witnessed. This article provides an introductory forensic analysis of the three current most popular web content management systems available, WordPress, Drupal, and Joomla! Test platforms have been created, and their site structures have been examined to provide guidance for forensic practitioners facing investigations of this type. Result's document available metadata for establishing site ownership, user interactions, and stored content following analysis of artifacts including Wordpress's wp_users, and wp_comments tables, Drupal's "watchdog" records, and Joomla!'s _users, and _content tables. Finally, investigatory limitations documenting the difficulties of investigating WCMS usage are noted, and analysis recommendations are offered. © 2018 American Academy of Forensic Sciences.

  1. Road transportation challenges and systems for the next decade

    International Nuclear Information System (INIS)

    Welbourne, E.R.

    1992-01-01

    An overview is presented of the historical evolution in road transport systems technology and regulations, and of developments foreseen in the next decade, in the contexts of safety, energy consumption and emissions, and the environment. Collision reduction technology including high centre mounted stop lights, antilock braking systems, headlight glare reduction, crashworthiness, and impact modes are discussed. Technology for reducing energy consumption, global climate change implications, chlorofluorocarbons, urban air quality impacts, and the conflict between improved safety and the environment (larger cars tend to be safer) are discussed. 13 refs

  2. New challenges to air/gas cleaning systems

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, J.L. [NUCON International, Inc., Columbus, OH (United States)

    1997-08-01

    This paper discusses the need for changes in the design and manufacturing of air and gas cleaning systems to meet waste management and site remediation requirements. Current design and manufacturing practices are primarily directed toward evaluating operational problems with existing systems in nuclear reactor facilities. However, nuclear waste management needs have developed which are much broader in scope and have different processing conditions. Numerous examples of air cleaning needs for waste management activities are provided; the major differences from operating facility needs are the requirement for continuous effluent treatment under widely different processing conditions. Related regulatory issues are also discussed briefly. 1 ref.

  3. Pilot Implementation of Health Information Systems: Issues and challenges

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2009-01-01

    Pilot implementation is a powerful and widely used approach in identifying design flaws and implementation issues before the full-scale deployment of new health information systems. However, pilot implementations often fail in the sense that they say little about the usability and usefulness...

  4. Opportunities and Challenges of Multi-Loop Aquaponic Systems

    NARCIS (Netherlands)

    Goddek, Simon

    2017-01-01

    Climate change requires new and innovative agricultural approaches to food security, especially in countries facing water scarcity. In this context, aquaponics could constitute a partial solution to tackle this issue. Traditional designs for one-loop aquaponic systems comprise of both aquaculture

  5. Mexico - The Federal Procurement System : Challenges and Opportunities

    OpenAIRE

    World Bank

    2007-01-01

    The World Bank carried out the first country procurement assessment review (CPAR) jointly with the Government in 2001, focusing on the features and performance of the federal procurement system. Based on the action plan included in the 2001 CPAR, the government reformed federal procurement laws and regulations in 2005 and furthered the development of Government Procurement Electronic Syste...

  6. Production systems of traditional leafy vegetables: Challenges for ...

    African Journals Online (AJOL)

    to access the indigenous or local knowledge associated with the production of these crops. This paper focuses on factors that are unique to TLV production systems. TLV production is dominated by women farmers in an attempt to sustain immediate household food security. The cultural environment within which the women ...

  7. The Evolution and Challenges of the Danish Civil Service System

    DEFF Research Database (Denmark)

    Hansen, Morten Balle

    2013-01-01

    service is examined. The Danish civil service system has been characterized by long-term gradual evolution and adoption of many of the prevailing institutions in medieval and modern European state administration. This adaptation to prevailing trends has been predominantly characterized by integration...

  8. Public Sector Agricultural Extension System Reform and the Challenges Ahead

    Science.gov (United States)

    Rivera, William M.

    2011-01-01

    This paper is organized into two main sections. The first section examines extension as an engine for innovation and reviews the numerous priorities confronting extension systems. Section two highlights the current knowledge imperative and the critical connection of extension to post-secondary higher education and training, organizational…

  9. Independent School Success Challenging the Danish Public School System

    Science.gov (United States)

    Ringsmose, Charlotte

    2013-01-01

    Denmark has had a long history of placing a high priority on education and public schooling. It is a declared goal of the Danish welfare system to provide comprehensive schooling, where children from different socioeconomic backgrounds can go to school together and have the same opportunities through education. It is also a declared goal for…

  10. Predictive maintenance of maritime systems : models and challenges

    NARCIS (Netherlands)

    Tinga, T.; Tiddens, W.W.; Amoiralis, F.; Politis, M.; Cepin, Marko; Bris, Radim

    2017-01-01

    To reduce maintenance and logistic costs and increase the asset availability, a predictive maintenance concept for maritime systems is developed. In the present paper, the physics-of-failure based prognostic methods will be introduced, but also other issues related to the development and application

  11. Security challenges for cooperative and interconnected mobility systems

    NARCIS (Netherlands)

    Bijlsma, T.; Kievit, S. de; Sluis, H.J.D. van de; Nunen, E. van; Passchier, I.; Luiijf, H.A.M.

    2013-01-01

    Software is becoming an important part of the innovation for vehicles. In addition, the systems in vehicles become interconnected and also get external connections, to the internet and Vehicular Ad hoc NETworks (VANETs). These trends form a combined security and safety threat, because recent

  12. Participatory Design and the Challenges of Large-Scale Systems

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2008-01-01

    With its 10th biannual anniversary conference, Participatory Design (PD) is leaving its teens and must now be considered ready to join the adult world. In this article we encourage the PD community to think big: PD should engage in large-scale information-systems development and opt for a PD...

  13. Mars Surface Systems Common Capabilities and Challenges for Human Missions

    Science.gov (United States)

    Toups, Larry; Hoffman, Stephen J.

    2016-01-01

    This paper describes the current status of common systems and operations as they are applied to actual locations on Mars that are representative of Exploration Zones (EZ) - NASA's term for candidate locations where humans could land, live and work on the Martian surface. Given NASA's current concepts for human missions to Mars, an EZ is a collection of Regions of Interest (ROIs) located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. An EZ also contains a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. The Evolvable Mars Campaign (EMC), a description of NASA's current approach to these human Mars missions, assumes that a single EZ will be identified within which NASA will establish a substantial and durable surface infrastructure that will be used by multiple human crews. The process of identifying and eventually selecting this single EZ will likely take many years to finalized. Because of this extended EZ selection process it becomes important to evaluate the current suite of surface systems and operations being evaluated for the EMC as they are likely to perform at a variety of proposed EZ locations and for the types of operations - both scientific and development - that are proposed for these candidate EZs. It is also important to evaluate proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. Four locations identified in the Mars Exploration Program Analysis Group (MEPAG)'s Human Exploration of Mars Science Analysis Group (HEM-SAG) report are used in this paper as representative of candidate EZs that will emerge from the selection process that NASA has initiated. A field

  14. Mars Surface System Common Capabilities and Challenges for Human Missions

    Science.gov (United States)

    Hoffman, Stephen J.; Toups, Larry

    2016-01-01

    NASA has begun a process to identify and evaluate candidate locations where humans could land, live and work on the martian surface. These locations are referred to as Exploration Zones (EZs). Given current mission concepts, an EZ is a collection of Regions of Interest (ROIs) that are located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains a landing site and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. In parallel with this process, NASA continues to make progress on the Evolvable Mars Campaign examining alternatives that can pioneer an extended human presence on Mars that is Earth independent. This involves ongoing assessments of surface systems and operations to enable a permanent, sustainable human presence. Because of the difficulty in getting equipment and supplies to the surface of Mars, part of these assessments involve identifying those systems and processes that can perform in multiple, sometimes completely unrelated, situations. These assessments have been performed in a very generic surface mission carried out at a very generic surface location. As specific candidate EZs are identified it becomes important to evaluate the current suite of surface systems and operations as they are likely to perform for the specific locations and for the types of operations - both scientific and development - that are proposed for these EZs. It is also important to evaluate the proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. This means looking at setting up and operating a field station at a central location within the EZ as well as traversing to and

  15. Developing and using expert systems and neural networks in medicine: a review on benefits and challenges.

    Science.gov (United States)

    Sheikhtaheri, Abbas; Sadoughi, Farahnaz; Hashemi Dehaghi, Zahra

    2014-09-01

    Complicacy of clinical decisions justifies utilization of information systems such as artificial intelligence (e.g. expert systems and neural networks) to achieve better decisions, however, application of these systems in the medical domain faces some challenges. We aimed at to review the applications of these systems in the medical domain and discuss about such challenges. Following a brief introduction of expert systems and neural networks by representing few examples, the challenges of these systems in the medical domain are discussed. We found that the applications of expert systems and artificial neural networks have been increased in the medical domain. These systems have shown many advantages such as utilization of experts' knowledge, gaining rare knowledge, more time for assessment of the decision, more consistent decisions, and shorter decision-making process. In spite of all these advantages, there are challenges ahead of developing and using such systems including maintenance, required experts, inputting patients' data into the system, problems for knowledge acquisition, problems in modeling medical knowledge, evaluation and validation of system performance, wrong recommendations and responsibility, limited domains of such systems and necessity of integrating such systems into the routine work flows. We concluded that expert systems and neural networks can be successfully used in medicine; however, there are many concerns and questions to be answered through future studies and discussions.

  16. Health information systems: challenges for the 21st century.

    Science.gov (United States)

    Ball, M J; Lillis, J C

    2000-08-01

    No longer focused on mere automation of manual processes, healthcare technology is poised to transform practice. Healthcare information systems can extend and enhance the memory; streamline administrative processes; provide access to information where, when, and how it is needed; and manage the cost of care while protecting and improving clinical quality and customer satisfaction. To reap the benefits of information systems, healthcare professionals must take stock of the industry's current position on the road to transformation and determine how to manage the journey ahead. This article explores healthcare information technology trends, discusses emerging technologies such as the Internet and the computerized patient record, and offers future recommendations for achieving technology integration and acceptance. Key to this discussion is the belief that people-based skills such as cooperation, leadership, and creative thinking are just as important as--if not more important than--the actual technology.

  17. Social-ecological system framework: initial changes and continuing challenges

    Directory of Open Access Journals (Sweden)

    Michael D. McGinnis

    2014-06-01

    Full Text Available The social-ecological system (SES framework investigated in this special issue enables researchers from diverse disciplinary backgrounds working on different resource sectors in disparate geographic areas, biophysical conditions, and temporal domains to share a common vocabulary for the construction and testing of alternative theories and models that determine which influences on processes and outcomes are especially critical in specific empirical settings. We summarize changes that have been made to this framework and discuss a few remaining ambiguities in its formulation. Specifically, we offer a tentative rearrangement of the list of relevant attributes of governance systems and discuss other ways to make this framework applicable to policy settings beyond natural resource settings. The SES framework will continue to change as more researchers apply it to additional contexts; the main purpose of this article is to delineate the version that served as the basis for the theoretical innovations and empirical analyses detailed in other contributions to this special issue.

  18. Water: Challenges at the Intersection of Human and Natural Systems

    Energy Technology Data Exchange (ETDEWEB)

    Futrell, J.H.; Gephart, R. E.; Kabat-Lensch, E.; McKnight, D. M.; Pyrtle, A.; Schimel, J. P.; Smyth, R. L.; Skole, D. L. Wilson, J. L.; Gephart, J. M.

    2005-09-01

    There is a growing recognition about the critical role water plays in sustaining people and society. This workshop established dialog between disciplinary scientists and program managers from diverse backgrounds in order to share perspectives and broaden community understanding of ongoing fundamental and applied research on water as a complex environmental problem. Three major scientific themes emerged: (1) coupling of cycles and process, with emphasis on the role of interfaces; (2) coupling of human and natural systems across spatial and temporal scales; and (3) prediction in the face of uncertainty. In addition, the need for observation systems, sensors, and infrastructure; and the need for data management and synthesis were addressed. Current barriers to progress were noted as educational and institutional barriers and the integration of science and policy.

  19. Health Behaviour Change Support Systems: Past Research and Future Challenges

    OpenAIRE

    Mettler, Tobias

    2015-01-01

    The emergence of mobile devices and social technologies has opened up new possibilities for health promotion and disease prevention. By means of emotional stimuli, motivation, and persuasion health behaviour change support systems (HBCSS) aim at influencing users to improve their health and wellbeing. This article presents the results of a bibliometric analysis related to the existing HBCSS body of knowledge. A total of 51 research studies were analysed with a look at their topical and theore...

  20. Challenges to the multilateral trading system and possible responses

    OpenAIRE

    Panagariya, Arvind

    2013-01-01

    This paper develops three major themes. First, the atmosphere of gloom around the multilateral trading system due to dim prospects of a successful conclusion of the Doha Round notwithstanding, global trade regime remains open and the institution in charge of it, the World Trade Organization, is in sound health. If anything, the Doha Round has been a victim of its own success: considerable de facto liberalization in agriculture has been achieved since the launch of the round. Second, to secure...

  1. Promoting better integration of health information systems: best practices and challenges

    NARCIS (Netherlands)

    Michelsen, K.; Brand, H.; Achterberg, P.; Wilkinson, J.

    2015-01-01

    Health Evidence Network Synthesis Report [Promoting better integration of health information systems: best practices and challenges K Michelsen, H Brand, P Achterberg, J Wilkinson - 2015 ... Authors Kai Michelsen Department of International Health, Maastricht University Maastricht,

  2. Context-aware Recommender Systems for Learning: a Survey and Future Challenges

    NARCIS (Netherlands)

    Verbert, Katrien; Manouselis, Nikos; Xavier, Ochoa; Wolpers, Martin; Drachsler, Hendrik; Ivana, Bosnic; Erik, Duval

    2011-01-01

    Verbert, K., Manouselis, N., Xavier, O., Wolpers, M., Drachsler, H., Bosnic, I., & Duval, E. (accepted). Context-aware Recommender Systems for Learning: a Survey and Future Challenges. IEEE Transactions on Learning Technologies (TLT).

  3. "Excuse me, where's the registration desk?" Report on Integrating Systems for the Robot Challenge AAAI 2002

    National Research Council Canada - National Science Library

    Perzanowski, Dennis; Schultz, Alan C; Adams, William; Bugajska, Magda; Abramson, M; MacMahon, M; Atrash, A; Coblenz, M

    2002-01-01

    ...., and the Naval Research Laboratory -- collaborated and integrated their various robotic systems and interfaces to attempt The Robot Challenge held at the AAAI 2002 annual conference in Edmonton, Alberta...

  4. The Emergence of Enterprise Systems Management - A Challenge to the IS Curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2005-01-01

    This paper proposes four cornerstones of a future Information Systems curriculum. It analyzes the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage resulting...... in the emergence of Enterprise Systems Management (ESM). Enterprise Systems Management calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways...

  5. Security, development and human rights: normative, legal and policy challenges for the international drug control system.

    Science.gov (United States)

    Barrett, Damon

    2010-03-01

    This commentary addresses some of the challenges posed by the broader normative, legal and policy framework of the United Nations for the international drug control system. The 'purposes and principles' of the United Nations are presented and set against the threat based rhetoric of the drug control system and the negative consequences of that system. Some of the challenges posed by human rights law and norms to the international drug control system are also described, and the need for an impact assessment of the current system alongside alternative policy options is highlighted as a necessary consequence of these analyses. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  6. Sustainable energy systems: Limitations and challenges based on exergy analysis

    OpenAIRE

    Woudstra, N.

    2012-01-01

    General There is a general understanding that the so-called “developed countries” have to change their way of life including their energy supply into a more sustainable way. But even in the case of unanimity with regard to the direction, there are still many opinions about the way to follow. This thesis discusses problems and possibilities of more sustainable energy systems first of all for the energy supply of the Netherlands. The “trias energetica” is used to distinguish the steps that have...

  7. Challenges in thermal and hydraulic analysis of ADS target systems

    International Nuclear Information System (INIS)

    Groetzbach, G.; Batta, A.; Lefhalm, C.-H.; Otic, I.

    2004-01-01

    The liquid metal cooled spallation targets of Accelerator Driven nuclear reactor Systems obey high thermal loads; in addition some flow and cooling conditions are of a prototypical character; in contrast the operating conditions for the engaged materials are narrow; thus, the target development requires a very careful analysis by experimental and numerical means. Especially the cooling of the steel window, which is heated by the proton beam, needs special care. Some of the main goals of the experimental and numerical analyses of the thermal dynamics of those systems are discusses. The prediction of locally detached flows and of flows with larger recirculation areas suffers from insufficient turbulence modeling; this has to be compensated by using prototypical model experiments, e.g. with water, to select the adequate models and numerical schemes. The well known problems with the Reynolds analogy in predicting the heat transfer in liquid metals requires always prototypic liquid metal experiments to select and adapt the turbulent heat flux models. The uncertainties in liquid metal experiments cannot be neglected; so it is necessary to perform CFD calculations and experiments always hand in hand and to develop improve turbulent heat flux models. One contribution to an improved 3 or 4-equation model is deduced from recent Direct Numerical Simulation (DNS) data. (author)

  8. Human capital flight challenges within an equitable health system.

    Science.gov (United States)

    Udonwa, N E

    2007-01-01

    The issue of human capital flight has been discussed at different forums with a consensus opinion that it has its merits and demerits to equitable health system. Most often one nation becomes a substantial net exporter of talent, leaving the provider nation at risk of depleting its natural supply of talent. This paper looks into the historical perspective of human capital flight or "brain drain", and its burden. It attempts to elucidate the various causes and suggested solutions. The paper's objective is to educate colleagues on the conceptual and contextual imperatives of the issue. Using a convenient sample of key informants who were medical colleagues in Nigeria relevant information was sourced from these colleagues, documents from the postgraduate medical college of Nigeria and the internet on maters relating to human capital flight and brain drain. Every year, thousands of qualified doctors, and other professionals leave Nigeria tempted by significantly higher wages, brighter prospects for employment and education, stability, food security. It appears that the potential exposure to different working conditions, resources and professional environments can be of advantage to the country, should Nigeria be able to recall these professionals. It also appears that necessary economic reforms that make staying at home rewarding, that is--good leadership, and policy planning that seriously looks into rural development, among other issues, are keys ingredients to reversing the trend in order to ensure a more equitable health system.

  9. The mental health system in Brazil: Policies and future challenges

    Directory of Open Access Journals (Sweden)

    Razzouk Denise

    2008-09-01

    Full Text Available Abstract Background The aim of this paper is to assess the mental health system in Brazil in relation to the human resources and the services available to the population. Methods The World Health Organization Assessment Instrument for Mental Health Systems (WHO AIMS was recently applied in Brazil. This paper will analyse data on the following sections of the WHO-AIMS: a mental health services; and b human resources. In addition, two more national datasets will be used to complete the information provided by the WHO questionnaire: a the Executive Bureau of the Department of Health (Datasus; and b the National Register of Health Institutions (CNS. Results There are 6003 psychiatrists, 18,763 psychologists, 1985 social workers, 3119 nurses and 3589 occupational therapists working for the Unified Health System (SUS. At primary care level, there are 104,789 doctors, 184, 437 nurses and nurse technicians and 210,887 health agents. The number of psychiatrists is roughly 5 per 100,000 inhabitants in the Southeast region, and the Northeast region has less than 1 psychiatrist per 100,000 inhabitants. The number of psychiatric nurses is insufficient in all geographical areas, and psychologists outnumber other mental health professionals in all regions of the country. The rate of beds in psychiatric hospitals in the country is 27.17 beds per 100,000 inhabitants. The rate of patients in psychiatric hospitals is 119 per 100,000 inhabitants. The average length of stay in mental hospitals is 65.29 days. In June 2006, there were 848 Community Psychosocial Centers (CAPS registered in Brazil, a ratio of 0.9 CAPS per 200,000 inhabitants, unequally distributed in the different geographical areas: the Northeast and the North regions having lower figures than the South and Southeast regions. Conclusion The country has opted for innovative services and programs, such as the expansion of Psychosocial Community Centers and the Return Home program to deinstitutionalize

  10. Changing tax system challenges producers and refiners in Russia

    International Nuclear Information System (INIS)

    Khartukov, E.M.

    1996-01-01

    Over the past several years, economics of the Russian oil industry has undergone considerable change reflecting the radical transformation of the country's core industry from a wholly state-run and heftily subsidized distribution system toward a formally privatized, cash-strapped, and quasi-market entrepreneurship. All-out price liberalization, launched by the Russian government at the start of 1992, did not apply to the national oil industry. Domestic oil prices remained tangibly restrained until mid-1993 and were officially deregulated in March 1995. Consequently, rising costs diminished profit margins of Russian oil producers, whose operating costs were never as low as popularly believed. This paper reviews the tax structure of the Russian oil industry showing the effects on exports, gas prices at the pumps, and distribution prices

  11. Simple model systems: a challenge for Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Di Carlo Marta

    2012-04-01

    Full Text Available Abstract The success of biomedical researches has led to improvement in human health and increased life expectancy. An unexpected consequence has been an increase of age-related diseases and, in particular, neurodegenerative diseases. These disorders are generally late onset and exhibit complex pathologies including memory loss, cognitive defects, movement disorders and death. Here, it is described as the use of simple animal models such as worms, fishes, flies, Ascidians and sea urchins, have facilitated the understanding of several biochemical mechanisms underlying Alzheimer's disease (AD, one of the most diffuse neurodegenerative pathologies. The discovery of specific genes and proteins associated with AD, and the development of new technologies for the production of transgenic animals, has helped researchers to overcome the lack of natural models. Moreover, simple model systems of AD have been utilized to obtain key information for evaluating potential therapeutic interventions and for testing efficacy of putative neuroprotective compounds.

  12. Underwater lidar system: design challenges and application in pollution detection

    Science.gov (United States)

    Gupta, Pradip; Sankolli, Swati; Chakraborty, A.

    2016-05-01

    The present remote sensing techniques have imposed limitations in the applications of LIDAR Technology. The fundamental sampling inadequacy of the remote sensing data obtained from satellites is that they cannot resolve in the third spatial dimension, the vertical. This limits our possibilities of measuring any vertical variability in the water column. Also the interaction between the physical and biological process in the oceans and their effects at subsequent depths cannot be modeled with present techniques. The idea behind this paper is to introduce underwater LIDAR measurement system by using a LIDAR mounted on an Autonomous Underwater Vehicle (AUV). The paper introduces working principles and design parameters for the LIDAR mounted AUV (AUV-LIDAR). Among several applications the papers discusses the possible use and advantages of AUV-LIDAR in water pollution detection through profiling of Dissolved Organic Matter (DOM) in water bodies.

  13. Inclusive Education as Complex Process and Challenge for School System

    Directory of Open Access Journals (Sweden)

    Al-Khamisy Danuta

    2015-08-01

    Full Text Available Education may be considered as a number of processes, actions and effects affecting human being, as the state or level of the results of these processes or as the modification of the functions, institutions and social practices roles, which in the result of inclusion become new, integrated system. Thus this is very complex process. Nowadays the complexity appears to be one of very significant terms both in science and in philosophy. It appears that despite searching for simple rules, strategies, solutions everything is still more complex. The environment is complex, the organism living in it and exploring it, and just the exploration itself is a complex phenomenon, much more than this could initially seem to be.

  14. A stratified myeloid system, the challenge of understanding macrophage diversity.

    Science.gov (United States)

    Geissmann, F; Mass, E

    2015-12-01

    The present issue of 'Seminars in Immunology' addresses the topic of macrophage biology, 100 years after the death of Elie Metchnikoff (May 1845-July 1916). As foreseen by Metchnikoff, the roles of macrophages in the maintenance of homeostasis and immunity against pathogens have become a broad and active area of investigation. We now start to realize that the myeloid system includes a multiplicity of cell types with diverse developmental origins and functions. Therefore, the textbook picture of a plastic and multifunctional macrophage does not meet the requirements of our current knowledge anymore. Further development toward a quantitative and molecular understanding of myeloid cell biology in vivo and their roles in tissue homeostasis and remodeling will benefit from taking this complexity into account. A tentative model to help in this pursuit and account for myeloid cell and macrophage diversity is discussed below. Copyright © 2016. Published by Elsevier Ltd.

  15. ETHICAL CHALLENGES OF THE E-LEARNING SYSTEM

    Directory of Open Access Journals (Sweden)

    MARIA CERNAT

    2013-05-01

    Full Text Available This article is the result of a four years teaching experience in one of the largest and controversial Romanian Universities using the E-learning system: Spiru Haret. It is a well-known fact that this was the first Romanian academic institution that used the E-learning techniques in wide and systematic way. Numerous articles appeared in the press in 2009 when the scandal of fake diplomas first started. This article is the perspective of an insider, that is, of someone who taught information and communication techniques in this institution for several years. I consider my experience and my findings to be balanced and objective and I also believe that we have to analyze things in a more profound and rational manner after the 2009 media storm ended. My article provides very useful information in this area since there are no academic articles on the way this Romanian academic institution (misunderstands the power of E-learning tools.

  16. The international nuclear non-proliferation system: Challenges and choices

    International Nuclear Information System (INIS)

    Simpson, J.; McGrew, A.G.

    1984-01-01

    When a topic has been under discussion for almost 40 years there is a danger that the literature will become excessively esoteric and that, as Philip Grummett suggests, '...a new scholasticism will arise' (p.79). Originating in a November l982 seminar co-sponsored by the British International Studies Association and the Foreign and Commonwealth Office, this volume is a refreshing, well conceived, and well written antidote to that trend. It is also well timed for the 1985 NPT Review Conference. The eight chapters of the volume are divided into three sections. Following an introduction by Anthony McGrew that touches on all the major themes of the volume, the first section deals with the existing non-proliferation system. In three chapters the historical, institutional and policy-making elements of the present system are outlined. There is a vignette on the Nuclear Suppliers Group in Wilmshurst's chapter one (pp. 28-33). Fischer's informative chapter on the IAEA is followed by Gummett's examination of policy options, including, for example, the linking of conventional weapons transfer to non-proliferation policies. The second section, also of three chapters, examines current issues: the state of the international nuclear industry, and the non-proliferation policies of the United States and Britain. Walker's chapter focuses chiefly on change in the industry-from monopoly to pluralism in suppliers, the effect of the economic recession, and the combined effect of these two factors on international politics. Devine's American non-proliferation chapter is a statement of the State Department view, whilst Keohane's chapter on Britain attempts to put the Trident procurement into a proliferation context. The British chapter is present because of ethnocentric considerations

  17. The international nuclear non-proliferation system: Challenges and choices

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, J.; McGrew, A.G.

    1984-01-01

    When a topic has been under discussion for almost 40 years there is a danger that the literature will become excessively esoteric and that, as Philip Grummett suggests, '...a new scholasticism will arise' (p.79). Originating in a November l982 seminar co-sponsored by the British International Studies Association and the Foreign and Commonwealth Office, this volume is a refreshing, well conceived, and well written antidote to that trend. It is also well timed for the 1985 NPT Review Conference. The eight chapters of the volume are divided into three sections. Following an introduction by Anthony McGrew that touches on all the major themes of the volume, the first section deals with the existing non-proliferation system. In three chapters the historical, institutional and policy-making elements of the present system are outlined. There is a vignette on the Nuclear Suppliers Group in Wilmshurst's chapter one (pp. 28-33). Fischer's informative chapter on the IAEA is followed by Gummett's examination of policy options, including, for example, the linking of conventional weapons transfer to non-proliferation policies. The second section, also of three chapters, examines current issues: the state of the international nuclear industry, and the non-proliferation policies of the United States and Britain. Walker's chapter focuses chiefly on change in the industry-from monopoly to pluralism in suppliers, the effect of the economic recession, and the combined effect of these two factors on international politics. Devine's American non-proliferation chapter is a statement of the State Department view, whilst Keohane's chapter on Britain attempts to put the Trident procurement into a proliferation context. The British chapter is present because of ethnocentric considerations.

  18. The Emergence of Enterprise Systems Management - A Challenge to the IS Curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    This paper proposes four cornerstones of a future Information Systems curriculum. It analyzes the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage resulting ...

  19. The Geopolitics of Climate Change: Challenges to the International System

    International Nuclear Information System (INIS)

    Halden, Peter

    2007-12-01

    This report analyses the consequences of climate change and global warming for international politics in general and international security in particular. The report focuses on whether and in what way climate change may alter the conditions of international security. From this perspective, the initial effects of climate change will vary according to existing economic, political and social structures in different world regions. Organised violence is more likely in regions with weak states and conflictual inter-state dynamics than in those characterised by co-operative relations. In the short- to medium term, climate change is unlikely to alter the constitutive structures of international security. However, depending on the severity of climate change, these conditions may change over the long term. Such changes will probably depend on the secondary effects that change has on the world and regional economies. Climate change is unlikely to lead to an increase in conflicts in the short- to medium term, but a long-term development marked by unmitigated climate change could very well have serious consequences for international security. The report argues that, although necessary, mitigation and adaptation measures may have consequences for international politics. These are due to the changes in social and political systems that they entail

  20. The Geopolitics of Climate Change: Challenges to the International System

    Energy Technology Data Exchange (ETDEWEB)

    Halden, Peter

    2007-12-15

    This report analyses the consequences of climate change and global warming for international politics in general and international security in particular. The report focuses on whether and in what way climate change may alter the conditions of international security. From this perspective, the initial effects of climate change will vary according to existing economic, political and social structures in different world regions. Organised violence is more likely in regions with weak states and conflictual inter-state dynamics than in those characterised by co-operative relations. In the short- to medium term, climate change is unlikely to alter the constitutive structures of international security. However, depending on the severity of climate change, these conditions may change over the long term. Such changes will probably depend on the secondary effects that change has on the world and regional economies. Climate change is unlikely to lead to an increase in conflicts in the short- to medium term, but a long-term development marked by unmitigated climate change could very well have serious consequences for international security. The report argues that, although necessary, mitigation and adaptation measures may have consequences for international politics. These are due to the changes in social and political systems that they entail.

  1. Computational brain models: Advances from system biology and future challenges

    Directory of Open Access Journals (Sweden)

    George E. Barreto

    2015-02-01

    Full Text Available Computational brain models focused on the interactions between neurons and astrocytes, modeled via metabolic reconstructions, are reviewed. The large source of experimental data provided by the -omics techniques and the advance/application of computational and data-management tools are being fundamental. For instance, in the understanding of the crosstalk between these cells, the key neuroprotective mechanisms mediated by astrocytes in specific metabolic scenarios (1 and the identification of biomarkers for neurodegenerative diseases (2,3. However, the modeling of these interactions demands a clear view of the metabolic and signaling pathways implicated, but most of them are controversial and are still under evaluation (4. Hence, to gain insight into the complexity of these interactions a current view of the main pathways implicated in the neuron-astrocyte communication processes have been made from recent experimental reports and reviews. Furthermore, target problems, limitations and main conclusions have been identified from metabolic models of the brain reported from 2010. Finally, key aspects to take into account into the development of a computational model of the brain and topics that could be approached from a systems biology perspective in future research are highlighted.

  2. What Are the Professional, Political, and Ethical Challenges of Co-Creating Health Care Systems?

    Science.gov (United States)

    Singh, Guddi; Owens, John; Cribb, Alan

    2017-11-01

    Co-creation is seen by many as a means of meeting the multiple challenges facing contemporary health care systems by involving institutions, professionals, patients, and stakeholders in new roles, relationships, and collaborative practices. While co-creation has the potential to positively transform health care systems, it generates a number of political and ethical challenges that should not be overlooked. We suggest that those involved in envisioning and implementing co-creation initiatives pay close attention to significant questions of equity, power, and justice and to the fundamental challenge of securing a common vision of the aims of and agendas for health care systems. While such initiatives present significant opportunities for improvement, they need to be viewed in light of their accompanying professional, political, and ethical challenges. © 2017 American Medical Association. All Rights Reserved.

  3. The emergence of enterprise systems management: a challenge to the IS curriculum

    DEFF Research Database (Denmark)

    Møller, Charles; Kræmmergaard, Pernille; Rikhardsson, Pall M.

    2006-01-01

    This paper proposes four cornerstones of a future Information Systems (IS) curriculum. It analyses the challenges of the IS curriculum based on the development of enterprise systems, and further argues that the practice and the research into enterprise systems have progressed to a new stage...... resulting in the emergence of Enterprise Systems Management (ESM). ESM calls for new competences and consequently represents new challenges to the IS curriculum. The paper outlines potential teaching issues and discusses the impact on the IS curriculum. Finally the paper suggests ways of approaching...

  4. Evolution of Hydro-systems: The 500-Year Challenge

    Science.gov (United States)

    Vörösmarty, C. J.; Band, L.; Lettenmaier, D. P.; Vogel, R. M.; Green, M. B.; Hermans, C.

    2008-12-01

    engineered water and land systems, and gives us a perspective on unfolding strategic water issues into the remainder of this century. This talk will present an overview of the rationale, modes of execution, and early results emerging from an NSF-funded hydrologic synthesis prototype effort.

  5. Some Challenges in the Design of Human-Automation Interaction for Safety-Critical Systems

    Science.gov (United States)

    Feary, Michael S.; Roth, Emilie

    2014-01-01

    Increasing amounts of automation are being introduced to safety-critical domains. While the introduction of automation has led to an overall increase in reliability and improved safety, it has also introduced a class of failure modes, and new challenges in risk assessment for the new systems, particularly in the assessment of rare events resulting from complex inter-related factors. Designing successful human-automation systems is challenging, and the challenges go beyond good interface development (e.g., Roth, Malin, & Schreckenghost 1997; Christoffersen & Woods, 2002). Human-automation design is particularly challenging when the underlying automation technology generates behavior that is difficult for the user to anticipate or understand. These challenges have been recognized in several safety-critical domains, and have resulted in increased efforts to develop training, procedures, regulations and guidance material (CAST, 2008, IAEA, 2001, FAA, 2013, ICAO, 2012). This paper points to the continuing need for new methods to describe and characterize the operational environment within which new automation concepts are being presented. We will describe challenges to the successful development and evaluation of human-automation systems in safety-critical domains, and describe some approaches that could be used to address these challenges. We will draw from experience with the aviation, spaceflight and nuclear power domains.

  6. Challenge of superfund community relations

    International Nuclear Information System (INIS)

    Goldman, N.J.

    1991-01-01

    Conducting a community relations effort in a community which is home to a Superfund site is a formidable challenge. Any education press, however appropriate, quickly falls victim to doubt, mistrust of fears of the very public intended to be served by the effort. While each site is uniquely different, the issues raised by affected communities in one part of the country are strikingly similar to those raised in other parts. Those most involved must join those most affected in seeking meaningful solutions and in building the trust that is so vital in moving forward with Superfund

  7. Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions

    NARCIS (Netherlands)

    Sandy, Heleau; Drachsler, Hendrik; Gillet, Dennis

    2009-01-01

    Heleou, S., Drachsler, H., & Gillet, D. (2009). Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions. 1st workshop on Context-aware Recommender Systems for Learning at the Alpine Rendez-Vous. November, 30-December, 3, 2009, Garmisch-Patenkirchen,

  8. Use of Point-of-Service Systems in School Nutrition Programs: Types, Challenges, and Employee Training

    Science.gov (United States)

    Lee, Yee Ming; Kwon, Junehee; Park, Eunhye; Wang, Yujia; Rushing, Keith

    2017-01-01

    Purpose/Objectives: This study investigated the use of electronic and paper-based point-of-service (POS) systems in school nutrition programs (SNPs), including associated challenges and the desired skills and existing training practices for personnel handling such systems. Methods: A questionnaire was developed based on interviews with 25 SNP…

  9. Why we need resilience thinking to meet societal challenges in bio-based production systems

    NARCIS (Netherlands)

    Ge, L.; Anten, N.P.R.; Dixhoorn, van I.D.E.; Feindt, P.H.; Kramer, K.; Leemans, H.B.J.; Gielen-Meuwissen, M.P.M.; Spoolder, H.A.M.; Sukkel, W.

    2016-01-01

    The need to feed an increasing world population and to
    respond to the effects of climate change creates
    unprecedented challenges for bio-based production systems.
    Many of these systems have been designed to maximize
    productivity and efficiency under standard

  10. Challenges in the Development of Environmental Management Systems on the Modern University Campus

    Science.gov (United States)

    Bero, Bridget N.; Doerry, Eckehard; Middleton, Ryan; Meinhardt, Christian

    2012-01-01

    Purpose: The purpose of this paper is to describe challenges and lessons learned in the design and development of a comprehensive, flexible environmental management system (EMS) in a real university setting; also to inform development of similar systems elsewhere and provide a modular, extensible software architecture for such efforts.…

  11. Challenge Study: A Project-Based Learning on a Wireless Communication System at Technical High School

    Science.gov (United States)

    Terasawa, Ikuo

    2016-01-01

    The challenge study is a project based learning curriculum at Technical High School aimed at the construction of a wireless communication system. The first period was engineering issues in the construction of an artificial satellite and the second period was a positional locating system based on the general purpose wire-less device--ZigBee device.…

  12. Challenges posed to the European pharmaceutical regulatory system by highly personalized medicines.

    Science.gov (United States)

    Johnston, John D; Feldschreiber, Peter

    2014-03-01

    The European pharmaceutical regulatory system has not yet been challenged by issues related to highly personalized medicines such as those to be found with active substances that affect RNA biochemistry. We review the current status of RNA-based pharmacology and present three possible case histories. The implications for the European pharmaceutical regulatory system are discussed. © 2013 The British Pharmacological Society.

  13. Systems analysis of carbon nanotubes: opportunities and challenges for space applications

    Science.gov (United States)

    Samareh, Jamshid A.; Siochi, Emilie J.

    2017-09-01

    Recent availability of carbon nanotubes (CNTs) in quantities and formats amenable to producing macroscale components invites consideration of these materials in space applications where their attractive properties can enable the realization of bold concepts for affordable space exploration. The challenge is to identify relevant systems and quantify the benefits at the systems level. Before significant investment or adoption of CNTs for large aerospace systems can be justified, there must be a plausible path to attain the perceived systems level benefits. This challenging step requires a close collaboration among experts on CNTs and aerospace system communities. This paper provides an overview of a few relevant potential CNTs applications for space systems and the gap that must be overcome for deployment of CNTs. It also provides a simple engineering-level systems analysis approach to quantify the benefits of using CNTs over state of the art material solutions.

  14. Localizing Global Medicine: Challenges and Opportunities in Cervical Screening in an Indigenous Community in Ecuador.

    Science.gov (United States)

    Nugus, Peter; Désalliers, Julie; Morales, Juana; Graves, Lisa; Evans, Andrea; Macaulay, Ann C

    2018-04-01

    This participatory research study examines the tensions and opportunities in accessing allopathic medicine, or biomedicine, in the context of a cervical cancer screening program in a rural indigenous community of Northern Ecuador. Focusing on the influence of social networks, the article extends research on "re-appropriation" of biomedicine. It does so by recognizing two competing tensions expressed through social interactions: suspicion of allopathic medicine and the desire to maximize one's health. Semistructured individual interviews and focus groups were conducted with 28 women who had previously participated in a government-sponsored cervical screening program. From inductive thematic analysis, the article traces these women's active agency in navigating coherent paths of health. Despite drawing on social networks to overcome formidable challenges, the participants faced enduring system obstacles-the organizational effects of the networks of allopathic medicine. Such obstacles need to be understood to reconcile competing knowledge systems and improve health care access in underresourced communities.

  15. Challenges in Evaluating Clinical Governance Systems in Iran: A Qualitative Study

    Science.gov (United States)

    Hooshmand, Elaheh; Tourani, Sogand; Ravaghi, Hamid; Ebrahimipour, Hossein

    2014-01-01

    Background: In spite of the pivotal role of clinical governance in enhancing quality of services provided by hospitals across the country, a scientific framework with specific criteria for evaluating hospitals has not been developed so far. Objectives: This study was conducted with the aim to identify the challenges involved in evaluating systems of clinical governance in Iran. Materials and Methods: For the purposes of this qualitative study, 15 semi-structured interviews with experts in the field were conducted in 2011 and the data were analyzed using framework analysis method. Results: Five major challenges in evaluating clinical governance include managing human resources, improving clinical quality, managing development, organizing clinical governance, and providing patient-oriented healthcare system. Conclusions: Healthcare system in Iran requires a clinical governance program which has a patient-oriented approach in philosophy, operation, and effectiveness in order to meet the challenges ahead. PMID:24910799

  16. Pre-Ebola virus disease laboratory system and related challenges in Liberia

    Directory of Open Access Journals (Sweden)

    Stephen B. Kennedy

    2016-10-01

    Full Text Available Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of effective and sustainablelaboratory services in Liberia. However, in a resource-limited environment such as Liberiaprogress regarding the rebuilding of the health system can be relatively slow, while efforts tosustain the transient gains remain a key challenge for the Ministry of Health. In this paper, wedescribe the pre-Ebola virus disease laboratory system in Liberia and its prevailing efforts toaddress future emerging infectious diseases, as well as current Infectious diseases, all of whichare exacerbated by poverty. We conclude that laboratory and diagnostic services in Liberiahave encountered numerous challenges regarding its efforts to strengthen the healthcaredelivery system. These challenges include limited trained human resource capacity, inadequateinfrastructure, and a lack of coordination. As with most countries in sub-Saharan Africa, whencomparing urban and rural settings, diagnostic and clinical services are generally skewedtoward urban health facilities and private, faith-based health facilities. We recommend thatstructured policy be directed at these challenges for national institutions to develop guidelinesto improve, strengthen and sustain diagnostic and curative laboratory services to effectivelyaddress current infectious diseases and prepare for future emerging and re-emerging infectiousdiseases.

  17. Architecting Cloud-Enabled Systems: A Systematic Survey of Challenges and Solutions

    DEFF Research Database (Denmark)

    Chauhan, Aufeef; Babar, Muhammad Ali; Benatallah, Boualem

    2016-01-01

    architectures for cloud-based systems. Our key conclusions are that a large number of primary studies focus on middleware services aimed at achieving scalability, performance, response time and efficient resource optimization. Architecting cloud-based systems presents unique challenges as the systems...... to be designed range from pervasive embedded systems and enterprise applications to smart devices with Internet of Things (IoTs). We also conclude that there is a huge potential of research on architecting cloud-based systems in areas related to green computing, energy efficient systems, mobile cloud computing...

  18. Application of Customer Relationship Management Systems in Business: Challenges and Opportunities

    OpenAIRE

    K. Liagkouras; K. Metaxiotis

    2014-01-01

    Customer relationship management (CRM) systems in business are a reality of the contemporary business world for the last decade or so. Still, there are grey areas regarding the successful implementation and operation of CRM systems in business. This paper, through the systematic study of the CRM implementation paradigm, attempts to identify the most important challenges and opportunities that the CRM systems face in a rapidly changing business world.

  19. Achieving Ultra-Reliable Low-Latency Communications: Challenges and Envisioned System Enhancements

    DEFF Research Database (Denmark)

    Pocovi Gerardino, Guillermo Andres; Shariatmadari, Hamidreza; Berardinelli, Gilberto

    2018-01-01

    URLLC have the potential to enable a new range of applications and services: from wireless control and automation in industrial environments to self-driving vehicles. 5G wireless systems are faced by different challenges for supporting URLLC. Some of the challenges, particularly in the downlink......-of-the-art solutions covering different aspects of the radio interface. In addition, system-level simulation results are presented, showing how the proposed techniques can work in harmony in order to fulfill the ambitious latency and reliability requirements of upcoming URLLC applications....

  20. JACoW Challenges of the ALICE Detector Control System for the LHC RUN3

    CERN Document Server

    Chochula, Peter; Bond, Peter; Kurepin, Alexander; Lechman, Mateusz; Lang, John; Pinazza, Ombretta

    2018-01-01

    The ALICE Detector Control System (DCS) has provided its services to the experiment since 10 years. During this period it ensured uninterrupted operation of the experiment and guaranteed stable conditions for the data taking. The DCS has been designed to cope with the detector requirements compatible with the LHC operation during its RUN1 and RUN2 phases. The decision to extend the lifetime of the experiment beyond this horizon requires the redesign of the DCS data flow and represents a major challenge. The major challenges of the system upgrade are presented in this paper.

  1. BIG DATA-Related Challenges and Opportunities in Earth System Modeling

    Science.gov (United States)

    Bamzai, A. S.

    2012-12-01

    Knowledge of the Earth's climate has increased immensely in recent decades, both through observational analysis and modeling. BIG DATA-related challenges emerge in our quest for understanding the variability and predictability of the climate and earth system on a range of time scales, as well as in our endeavor to improve predictive capability using state-of-the-science models. To enable further scientific discovery, bottlenecks in current paradigms need to be addressed. An overview of current NSF activities in Earth System Modeling with a focus on associated data-related challenges and opportunities, will be presented.

  2. Rectifier Design Challenges for RF Wireless Power Transfer and Energy Harvesting Systems

    Directory of Open Access Journals (Sweden)

    A. Collado

    2017-06-01

    Full Text Available The design of wireless power transfer (WPT and energy harvesting (EH solutions poses different challenges towards achieving maximum RF-DC conversion efficiency in these systems. This paper covers several selected challenges when developing WPT and electromagnetic EH solutions, such as the design of multiband and broadband rectifiers, the minimization of the effect that load and input power variations may have on the system performance and finally the most optimum power combining mechanisms that can be used when dealing with multi-element rectifiers.

  3. INTEGRATION CHALLENGES OF UNIVERSITY AND INFORMATION MANAGEMENT SYSTEM (UIMS TO MOODLE

    Directory of Open Access Journals (Sweden)

    Jyldyzbek J. Jakshylykov

    2016-06-01

    Full Text Available Introduction: in 2006 an International Ataturk Ala-Too University (IAAU began to adopt internationally recognised Bologna system, which was initiated by the Ministry of Science and Education of Kyrgyz Republic because of problems of managerial and educational problems at universities in Kyrgyzstan. Consequently, IAAU had to improve its information and grading system and created University Information and Manage¬ment System (UIMS, which was developed by the university professional team including the author. At the same time, the university began to apply a Moodle software, which delivers open source management system programs, in order to appropriately manage teaching proc esses and manage courses online. Materials and Methods: the methodological basis of the research are descriptive method, analysis, and comparison. Results: however, the IAAU faced some challenged issues in the application of the two innovation, which was the integration challenges of those Moodle and UIMS. Hence, the main purpose of this study is to demonstrate benefits of Moodle and UIMS linking challenges. at first, this paper informs Moodle functions, features, advantages and disadvantages in a shortly manner and UIMS management features and primary functions, which included six fundamentally crucial processes with some graphical representations. In addition, the analysis and methodologies of two systems through identifying advantages and disadvantages for the possible integ ration. Discussion and Conclusions: at the end, some challenged issues were identified from analysis results, also Moodle and UIMS benefits were demonstrated in the International Ataturk Ala-Too University.

  4. Hybrid Societies: Challenges and Perspectives in the Design of Collective Behavior in Self-organizing Systems

    Directory of Open Access Journals (Sweden)

    Heiko eHamann

    2016-04-01

    Full Text Available Hybrid societies are self-organizing, collective systems composed of different components, for example, natural and artificial parts (bio-hybrid or human beings interacting with and through technical systems (socio-technical. Many different disciplines investigate methods and systems closely related to the design of hybrid societies. A~stronger collaboration between these disciplines could allow for re-use of methods and create significant synergies. We identify three main areas of challenges in the design of self-organizing hybrid societies. First, we identify the formalization challenge. There is an urgent need for a generic model that allows a description and comparison of collective hybrid societies. Second, we identify the system design challenge. Starting from the formal specification of the system, we need to develop an integrated design process. Third, we identify the challenge of interdisciplinarity. Current research on self-organizing hybrid societies stretches over many different fields and hence requires the re-use and synthesis of methods at intersections between disciplines. We then conclude by presenting our perspective for future approaches with high potential in this area.

  5. Challenges when evaluating Product/Service-Systems through Life Cycle Assessment

    DEFF Research Database (Denmark)

    Kjær, Louise Laumann; Pagoropoulos, Aris; Schmidt, Jannick H.

    2016-01-01

    the environmental performance of PSS. We identify a set of PSS characteristics that can challenge an LCA study. Three relevant scopes are distinguished, where LCA may be applied: (1) evaluating options within the PSS itself; (2) comparing a PSS with an alternative; and (3) modelling the actual contextual changes...... caused by the PSS. We derive three pronounced challenges when conducting LCA within the three scopes: (i) identifying and defining the reference system; (ii) defining the functional unit; and (iii) setting system boundaries. We elaborate on how these challenges are discussed in current literature....... Recommended future work includes developing adapted guidelines and further empirical case studies that quantify the environmental changes and impacts caused by introducing PSS....

  6. Challenges of using Hospital Information Systems by nurses: comparing academic and non-academic hospitals.

    Science.gov (United States)

    Ahmadian, Leila; Dorosti, Nafise; Khajouei, Reza; Gohari, Sadrieh Hajesmaeel

    2017-06-01

    Hospital Information Systems (HIS) are used for easy access to information, improvement of documentation and reducing errors. Nonetheless, using these systems is faced with some barriers and obstacles. This study identifies the challenges and the obstacles of using these systems in the academic and non-academic hospitals in Kerman. This is a cross-sectional study which was carried out in 2015. The statistical population in this study consisted of the nurses who had been working in the academic and non-academic hospitals in Kerman. A questionnaire consisting of two sections was used. The first section consisted of the demographic information of the participants and the second section comprised 34 questions about the challenges of HIS use. Data were analyzed by the descriptive and statistical analysis (t-test, and ANOVA) using SPSS 19 software. The most common and important challenges in the academic hospitals were about human environment factors, particularly "negative attitude of society toward using HIS". In the non-academic hospitals, the most common and important challenges were related to human factors, and among them, "no incentive to use system" was the main factor. The results of the t-test method revealed that there was a significant relationship between gender and the mean score of challenges related to the organizational environment category in the academic hospitals and between familiarity with HIS and mean score of human environment factors (pinformation systems are the factors related to the human environment and the human factors. The results of this study can bring a good perspective to the policy makers and the managers regarding obstacles of using HISs from the nurses' perspective, so that they can solve their problems and can successfully implement these systems.

  7. Preparing Information Systems (IS) Graduates to Meet the Challenges of Global IT Security: Some Suggestions

    Science.gov (United States)

    Sauls, Jeff; Gudigantala, Naveen

    2013-01-01

    Managing IT security and assurance is a top priority for organizations. Aware of the costs associated with a security or privacy breach, organizations are constantly vigilant about protecting their data and IT systems. In addition, organizations are investing heavily in IT resources to keep up with the challenges of managing their IT security and…

  8. Spatial agent-based models for socio-ecological systems: challenges and prospects

    NARCIS (Netherlands)

    de Filatova, T.; Verburg, P.H.; Parker, D.C.; Stannard, S.R.

    2013-01-01

    Departing from the comprehensive reviews carried out in the field, we identify the key challenges that agent-based methodology faces when modeling coupled socio-ecological systems. Focusing primarily on the papers presented in this thematic issue, we review progress in spatial agent-based models

  9. Organic Coasts? Regulatory Challenges of Certifying Integrated Shrimp-Mangrove Production Systems in Vietnam

    Science.gov (United States)

    Ha, Tran Thi Thu; Bush, Simon R.; Mol, Arthur P. J.; van Dijk, Han

    2012-01-01

    The Vietnamese government aims to expand the scale of Naturland certified organic production in integrated shrimp-mangrove farming systems across the coast of Ca Mau province by 2015. In doing so the division between public and private regulation has become blurred. We analyze the government's goal by examining the regulatory challenges of using…

  10. Challenges Faced by Undergraduate Military Students at American Public University System

    Science.gov (United States)

    Machuca, Ana; Torres, Karin; Morris, Pamela; Whitley, William

    2014-01-01

    This paper will summarize some of challenges faced by military students enrolled in an associate and bachelors online program at American Public University System (APUS). The survey results on which the study is based exposed the following problems faced by military personnel: 48.7% had difficulties working around military obligations, 33.3%…

  11. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    Directory of Open Access Journals (Sweden)

    Xavier Bosch-Capblanch

    Full Text Available In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  12. Legitimacy challenges of intermediary gatekeeping in the Chinese internet regulatory system

    NARCIS (Netherlands)

    Wei, Lulu

    2018-01-01

    Legitimacy Challenges of Intermediary Gatekeeping in the Chinese Internet Regulatory System In the Chinese legal and political framework, in order for the government to maintain control over information posted on social media platforms, commercial internet intermediaries are assigned the role of

  13. Information and Communications Technology (ICT) in Nigeria Educational Assessment System--Emerging Challenges

    Science.gov (United States)

    Aworanti, Olatunde Awotokun

    2016-01-01

    This paper examines Information and Communications Technology (ICT) in Nigeria educational assessment system with its emerging challenges. This is inevitable following the globalisation trend which has brought drastic changes in the world of technology. The essence of the paper is to describe the present status of ICT in the Nigeria educational…

  14. Towards a Standardized e-Assessment System: Motivations, Challenges and First Findings

    Directory of Open Access Journals (Sweden)

    Denis Helic

    2009-10-01

    Full Text Available “Global Learning” with shared learning contents, resources, activities and goals is one of the contributions of Globalization. With the capability to use new Information and Communication Technologies (ICT it is a bit easier to have a technology based learning systems that enable learners to share the learning resources and possibilities. As a result many Learning Management Systems (LMS were developed with divers of platforms and approaches. Consequently, sharing learning resources and components has become a major challenge. E-assessment as a primary activity of any LMS is facing the same challenges and problems. In order to stand on this challenge people in the field of technology enhanced learning have recommended that LMS should conform to specific standards. This paper discuses this challenge, the consequences and limitations of standards in the modern learning settings. Moreover, it shows a service oriented framework for assessment which aims to make the e-assessment systems flexible and also to initiate the term of “Global Learning Assessment” with the possibility of sharing the e-assessment system components.

  15. Verification and Validation Challenges for Adaptive Flight Control of Complex Autonomous Systems

    Science.gov (United States)

    Nguyen, Nhan T.

    2018-01-01

    Autonomy of aerospace systems requires the ability for flight control systems to be able to adapt to complex uncertain dynamic environment. In spite of the five decades of research in adaptive control, the fact still remains that currently no adaptive control system has ever been deployed on any safety-critical or human-rated production systems such as passenger transport aircraft. The problem lies in the difficulty with the certification of adaptive control systems since existing certification methods cannot readily be used for nonlinear adaptive control systems. Research to address the notion of metrics for adaptive control began to appear in the recent years. These metrics, if accepted, could pave a path towards certification that would potentially lead to the adoption of adaptive control as a future control technology for safety-critical and human-rated production systems. Development of certifiable adaptive control systems represents a major challenge to overcome. Adaptive control systems with learning algorithms will never become part of the future unless it can be proven that they are highly safe and reliable. Rigorous methods for adaptive control software verification and validation must therefore be developed to ensure that adaptive control system software failures will not occur, to verify that the adaptive control system functions as required, to eliminate unintended functionality, and to demonstrate that certification requirements imposed by regulatory bodies such as the Federal Aviation Administration (FAA) can be satisfied. This presentation will discuss some of the technical issues with adaptive flight control and related V&V challenges.

  16. Challenges in developing a comprehensive, automated and flexible oil accounting system

    Energy Technology Data Exchange (ETDEWEB)

    Nordell, L.F.; Ruda, H. [Enbridge Pipelines Inc., Edmonton, AB (Canada)

    2004-07-01

    Enbridge Pipelines Inc. operates a long and complex system of pipelines which transport hydrocarbon liquid commodities, including crude oils, refined products and natural gas liquids across provincial and national boundaries. Due to growing internal demands for the addition of pipelines, the company developed a comprehensive oil accounting (OA) system in 1998. The OA accommodated changing business requirements by incorporating more complex tariff agreements and the demand for customized system reporting for customers. The new OA was also compatible with the company's technology direction, which focused on aligning information technology (IT) with business drivers and upgrading the flexibility of the entire OA system. This paper summarized the business improvement and redevelopment study; the OA system redevelopment project; challenges of integrating new system components with the legacy system during system development; specific process improvement results that were targeted and achieved by the new system development team; and, the project development challenges. The project team adopted a software development approach that was responsive to changes in the requirements and in the project direction introduced by key stakeholders during the life of the project. The project management approaches and logic of the SCRUM and extreme programming (XP) methods were combined to incorporate the principles of agile development to ensure a quality product. The result was an automated crude oil balancing and revenue accounting system that interfaced with other pipeline management software systems. 6 refs., 5 figs.

  17. Benefits and challenges of cloud ERP systems – A systematic literature review

    Directory of Open Access Journals (Sweden)

    Mohamed A. Abd Elmonem

    2016-12-01

    Full Text Available Enterprise Resource Planning (ERP systems provide extensive benefits and facilities to the whole enterprise. ERP systems help the enterprise to share and transfer data and information across all functions units inside and outside the enterprise. Sharing data and information between enterprise departments helps in many aspects and aims to achieve different objectives. Cloud computing is a computing model which takes place over the internet and provides scalability, reliability, availability and low cost of computer reassures. Implementing and running ERP systems over the cloud offers great advantages and benefits, in spite of its many difficulties and challenges. In this paper, we follow the Systematic Literature Review (SLR research method to explore the benefits and challenges of implementing ERP systems over a cloud environment.

  18. The Grand Challenges of WCRP and the Climate Observing System of the Future

    Science.gov (United States)

    Brasseur, G. P.

    2017-12-01

    The successful implementation the Paris agreement on climate change (COP21) calls for a well-designed global monitoring system of essential climate variables, climate processes and Earth system budgets. The Grand Challenges implemented by the World Climate Research Programme (WCRP) provide an opportunity to investigate issues of high societal relevance, directly related to sea level rise, droughts, floods, extreme heat events, food security, and fresh water availability. These challenges would directly benefit from a well-designed suite of systematic climate observations. Quantification of the evolution of the global energy, water and carbon budgets as well as the development and the production of near-term and regional climate predictions require that a comprehensive, focused, multi-platform observing system (satellites, ground-based and in situ observations) be established in an international context. This system must be accompanied by the development of climate services that should translate and disseminate scientific outcomes as actionable information for users and stakeholders.

  19. CAR T Cell Therapy for Glioblastoma: Recent Clinical Advances and Future Challenges.

    Science.gov (United States)

    Bagley, Stephen J; Desai, Arati S; Linette, Gerald P; June, Carl H; O'Rourke, Donald M

    2018-03-02

    In patients with certain hematologic malignancies, the use of autologous T cells genetically modified to express chimeric antigen receptors (CARs) has led to unprecedented clinical responses. Although progress in solid tumors has been elusive, recent clinical studies have demonstrated the feasibility and safety of CAR T cell therapy for glioblastoma. In addition, despite formidable barriers to T cell localization and effector function in glioblastoma, signs of efficacy have been observed in select patients. In this review, we begin with a discussion of established obstacles to systemic therapy in glioblastoma and how these may be overcome by CAR T cells. We continue with a summary of previously published CAR T cell trials in GBM, and end by outlining the key therapeutic challenges associated with the use of CAR T cells in this disease.

  20. Cervical cancer data and data systems in limited-resource settings: Challenges and opportunities.

    Science.gov (United States)

    Drummond, Jennifer L; Were, Martin C; Arrossi, Silvina; Wools-Kaloustian, Kara

    2017-07-01

    Appropriate collection and use of health information is critical to the planning, scaling up, and improvement of cervical cancer programs. The health information systems implementation landscape is unique to each country; however, systems serving cervical cancer programs in low-resource settings share characteristics that present common challenges. In response, many programs have taken innovative approaches to generating the quality information needed for decision making. Recent advances in health information technology also provide feasible solutions to challenges. This article draws from the experiences of the authors and from current literature to describe outstanding challenges and promising practices in the implementation of cervical cancer data systems, and to make recommendations for next steps. Recommendations include engaging all stakeholders-including providers, program managers, implementing partners, and donors-in promoting national, district, and community information systems; building on existing systems and processes, as well as introducing new technologies; and evolving data collection and data systems as programs advance. © 2017 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.

  1. Social work in the Veterans Health Administration (VA) System: rewards, challenges, roles and interventions.

    Science.gov (United States)

    Beder, Joan; Postiglione, Paul

    2013-01-01

    For the social worker in the Veterans Health Administration (VA) System, numerous challenges are faced and met while serving the nation's Veterans. As part of the multidisciplinary team, social workers perform a variety of tasks and function in diverse roles. The qualitative survey research reported in this article sought to detail what social workers identified about the impact and rewards of their work and what they saw as the challenges and frustrations. In addition the social workers were asked to clarify their role with the patient and the family. Intervention strategies used in the course of the social workers interaction with the Veterans was also ascertained.

  2. Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.

    Science.gov (United States)

    Hill, A J; Blundell, J E

    1990-03-01

    The sensitivity of the appetite system of a group of obese individuals was assessed in response to two challenges known to reduce hunger and enhance satiety in lean people. The challenges were the presentation of a caloric (high protein) load and the activation of serotonin systems. Eight obese female adults (BMI = 38) received 2 X 15 mg d-fenfluramine or placebo daily for 3 days, the study conforming to a 2 X 2 factor (drug X lunch type), double blind, repeated measures design. Three hours after dosing on day 3 they ate either a high carbohydrate (63 percent of total energy) or high protein (54 percent) lunchtime meal (the caloric load). These fixed meal challenges were equal in energy (475 kcal), weight and fat content. Ratings of hunger motivation and food preferences were tracked over the course of lunch and for a further 3 hours, at which point subjects returned for a self-selection test meal. Intakes from this second open meal revealed significant main effects of both caloric load and drug on energy intake, with the high protein d-fenfluramine combination being the most potent anorectic pairing. These findings were supported by the profiles of hunger motivation. This study has confirmed that the appetite system of these subjects was responsive to these biologically relevant challenges. The results suggest that the combination of an appetite modulating drug with specific dietary intervention may represent an effective strategy for the management of hunger arising from caloric restriction.

  3. HIV Infection among People Who Inject Drugs: The Challenge of Racial/Ethnic Disparities

    Science.gov (United States)

    Des Jarlais, Don C.; McCarty, Dennis; Vega, William A.; Bramson, Heidi

    2013-01-01

    Racial/ethnic disparities in HIV infection, with minority groups typically having higher rates of infection, are a formidable public health challenge. In the United States, among both men and women who inject drugs, HIV infection rates are elevated among Hispanics and non-Hispanic Blacks. A meta-analysis of international research concluded that…

  4. Reinforced Ultra-Tightly Coupled GPS/INS System for Challenging Environment

    Directory of Open Access Journals (Sweden)

    Xueyun Wang

    2014-01-01

    Full Text Available Among all integration levels currently available for Global Positioning System (GPS and Inertial Navigation System (INS Integrated System, ultra-tightly coupled (UTC GPS/INS system is the best choice for accurate and reliable navigation. Nevertheless the performance of UTC GPS/INS system degrades in challenging environments, such as jamming, changing noise of GPS signals, and high dynamic maneuvers. When low-end Inertial Measurement Units (IMUs based on MEMS sensors are employed, the performance degradation will be more severe. To solve this problem, a reinforced UTC GPS/INS system is proposed. Two techniques are adopted to deal with jamming and high dynamics. Firstly, adaptive integration Kalman filter (IKF based on fuzzy logics is developed to reinforce the antijamming ability. The parameters of membership functions (MFs are adjusted and optimized through self-developed neutral network. Secondly, a Doppler frequency error estimator based on Kalman filter is designed to improve the navigation performance under high dynamics. A complete simulation platform is established to evaluate the reinforced system. Results demonstrate that the proposed system architecture significantly improves navigation performance in challenging environments and it is a more advanced solution to accurate and reliable navigation than traditional UTC GPS/INS system.

  5. Industrial Adoption of Model-Based Systems Engineering: Challenges and Strategies

    Science.gov (United States)

    Maheshwari, Apoorv

    As design teams are becoming more globally integrated, one of the biggest challenges is to efficiently communicate across the team. The increasing complexity and multi-disciplinary nature of the products are also making it difficult to keep track of all the information generated during the design process by these global team members. System engineers have identified Model-based Systems Engineering (MBSE) as a possible solution where the emphasis is placed on the application of visual modeling methods and best practices to systems engineering (SE) activities right from the beginning of the conceptual design phases through to the end of the product lifecycle. Despite several advantages, there are multiple challenges restricting the adoption of MBSE by industry. We mainly consider the following two challenges: a) Industry perceives MBSE just as a diagramming tool and does not see too much value in MBSE; b) Industrial adopters are skeptical if the products developed using MBSE approach will be accepted by the regulatory bodies. To provide counter evidence to the former challenge, we developed a generic framework for translation from an MBSE tool (Systems Modeling Language, SysML) to an analysis tool (Agent-Based Modeling, ABM). The translation is demonstrated using a simplified air traffic management problem and provides an example of a potential quite significant value: the ability to use MBSE representations directly in an analysis setting. For the latter challenge, we are developing a reference model that uses SysML to represent a generic infusion pump and SE process for planning, developing, and obtaining regulatory approval of a medical device. This reference model demonstrates how regulatory requirements can be captured effectively through model-based representations. We will present another case study at the end where we will apply the knowledge gained from both case studies to a UAV design problem.

  6. Regionalization in the SUS: implementation process, challenges and perspectives in the critical view of system managers.

    Science.gov (United States)

    Carvalho, Andre Luis Bonifácio de; Jesus, Washington Luiz Abreu de; Senra, Isabel Maria Vilas Boas

    2017-04-01

    This article examines the regionalization process in the Brazilian Health System, identifying frameworks and challenges of this process from critical dialogue on the subject, contextualized by the experience of the management system and in the light of an established theoretical debate in the last decade. We used the thematic content analysis of legal and documentary surveys of the regionalization process in SUS, collated by elements of the historical and political context in the period. As evidence, it appears that the regionalization process has been incremental decentralization/deconcentration of management and health actions and services. There are important challenges, particularly in relation to ensuring access and system governance structure, which contributes to critical thinking and construction of new perspectives by those who lead their implementation.

  7. Social challenges when implementing information systems in everyday work in a nursing context.

    Science.gov (United States)

    Nilsson, Lina; Eriksén, Sara; Borg, Christel

    2014-09-01

    Implementation of information systems in healthcare has become a lengthy process where healthcare staff (eg, nurses) are expected to put information into systems without getting the overall picture of the potential usefulness for their own work. The aim of this study was to explore social challenges when implementing information systems in everyday work in a nursing context. Moreover, this study aimed at putting perceived social challenges in a theoretical framework to address them more constructively when implementing information systems in healthcare. Influenced by institutional ethnography, the findings are based on interviews, observations, and written reflections. Power (changing the existing hierarchy, alienation), professional identity (calling on hold, expert becomes novice, changed routines), and encounter (ignorant introductions, preconceived notions) were categories (subcategories) presented in the findings. Social Cognitive Theory, Diffusion of Innovations, organizational culture, and dramaturgical analysis are proposed to set up a theoretical framework. If social challenges are not considered and addressed in the implementation process, it will be affected by nurses' solidarity to existing power structures and their own professional identity. Thus, implementation of information systems affects more aspects in the organization than might have been intended. These aspects need to be taken in to account in the implementation process.

  8. Model-based nonlinear control of hydraulic servo systems: Challenges, developments and perspectives

    Science.gov (United States)

    Yao, Jianyong

    2018-06-01

    Hydraulic servo system plays a significant role in industries, and usually acts as a core point in control and power transmission. Although linear theory-based control methods have been well established, advanced controller design methods for hydraulic servo system to achieve high performance is still an unending pursuit along with the development of modern industry. Essential nonlinearity is a unique feature and makes model-based nonlinear control more attractive, due to benefit from prior knowledge of the servo valve controlled hydraulic system. In this paper, a discussion for challenges in model-based nonlinear control, latest developments and brief perspectives of hydraulic servo systems are presented: Modelling uncertainty in hydraulic system is a major challenge, which includes parametric uncertainty and time-varying disturbance; some specific requirements also arise ad hoc difficulties such as nonlinear friction during low velocity tracking, severe disturbance, periodic disturbance, etc.; to handle various challenges, nonlinear solutions including parameter adaptation, nonlinear robust control, state and disturbance observation, backstepping design and so on, are proposed and integrated, theoretical analysis and lots of applications reveal their powerful capability to solve pertinent problems; and at the end, some perspectives and associated research topics (measurement noise, constraints, inner valve dynamics, input nonlinearity, etc.) in nonlinear hydraulic servo control are briefly explored and discussed.

  9. Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems.

    Science.gov (United States)

    Hughes, David J; Kostrzewski, Tomasz; Sceats, Emma L

    2017-10-01

    Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge. The maintenance of functional primary hepatocytes cultures, the parenchymal cell of the liver, has historically been difficult with dedifferentiation and the consequent loss of hepatic function limiting utility. The desire for longer term functional liver cultures sparked the development of numerous systems, including collagen sandwiches, spheroids, micropatterned co-cultures and liver microphysiological systems. This review will focus on liver microphysiological systems, often referred to as liver-on-a-chip, and broaden to include platforms with interconnected microphysiological systems or multi-organ-chips. The interconnection of microphysiological systems presents the opportunity to explore system level effects, investigate organ cross talk, and address questions which were previously the preserve of animal experimentation. As a field, microphysiological systems have reached a level of maturity suitable for commercialization and consequent evaluation by a wider community of users, in academia and the pharmaceutical industry. Here scientific, operational, and organizational considerations relevant to the wider adoption of microphysiological systems will be discussed. Applications in which microphysiological systems might offer unique scientific insights or enable studies currently feasible only with animal models are described, and challenges which might be addressed to enable wider adoption of the technologies are highlighted. A path forward which envisions the development of microphysiological systems in partnerships between academia, vendors and industry, is proposed. Impact statement Microphysiological systems are in vitro models of human tissues and organs. These systems have advanced rapidly in recent years and are now being

  10. Large system change challenges: addressing complex critical issues in linked physical and social domains

    Science.gov (United States)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

    2015-04-01

    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  11. Systems Engineering in the Information Age: The Challenge of Mega-Systems

    National Research Council Canada - National Science Library

    Stevens, Renee

    2004-01-01

    .... We call these mega-systems. This paper focuses on the engineering of this class of systems which is characterized by increasing scale, the nature and pace of change of the technologies involved, the complexity of system...

  12. The national system of nuclear material control development and challenges. Vol. 3

    International Nuclear Information System (INIS)

    Badawy, I.

    1996-01-01

    This paper presents the major factors which may affect the implementation of the National System of Nuclear Material Accounting and Safeguards in Egypt. Developments of this National System-being a division of the Nuclear Regulatory Body in the country-are discussed. Also, recent requirements of the International Atomic Energy Agency within the policy of strengthening its regime of international nuclear control are reviewed. The challenges facing the National System are indicated taking in consideration the anticipated growth in the nuclear field in Egypt by the year 2000 and after. 2 figs

  13. Challenges of Utilizing E-Learning Systems in Public Universities in Jordan

    Directory of Open Access Journals (Sweden)

    Muhannad Anwar Al-Shboul

    2010-06-01

    Full Text Available This research paper lists and discusses major challenges and barriers that may face faculty members at the public universities in Jordan in employing e-Learning systems authoring tools in their instructions. It also proposes several suggestions for the administrators in public universities in Jordan for what they could do to improve the utilization of e-Learning authoring tools at their campuses. E-Learning systems authoring tools allow instructors to easily create and deliver their e-contents and e-lectures. Furthermore, online course materials which uploaded by using such authoring tools could be viewed by any popular web browser system.

  14. The national system of nuclear material control development and challenges. Vol. 3

    Energy Technology Data Exchange (ETDEWEB)

    Badawy, I [National Centre for Nuclear Safety and Radiation Control, Atomic Energy Authority, Cairo (Egypt)

    1996-03-01

    This paper presents the major factors which may affect the implementation of the National System of Nuclear Material Accounting and Safeguards in Egypt. Developments of this National System-being a division of the Nuclear Regulatory Body in the country-are discussed. Also, recent requirements of the International Atomic Energy Agency within the policy of strengthening its regime of international nuclear control are reviewed. The challenges facing the National System are indicated taking in consideration the anticipated growth in the nuclear field in Egypt by the year 2000 and after. 2 figs.

  15. System Engineering and Technical Challenges Overcome in the J-2X Rocket Engine Development Project

    Science.gov (United States)

    Ballard, Richard O.

    2012-01-01

    Beginning in 2006, NASA initiated the J-2X engine development effort to develop an upper stage propulsion system to enable the achievement of the primary objectives of the Constellation program (CxP): provide continued access to the International Space Station following the retirement of the Space Station and return humans to the moon. The J-2X system requirements identified to accomplish this were very challenging and the time expended over the five years following the beginning of the J- 2X effort have been noteworthy in the development of innovations in both the fields for liquid rocket propulsion and system engineering.

  16. Evolution of the Darlington NGS fuel handling computer systems

    International Nuclear Information System (INIS)

    Leung, V.; Crouse, B.

    1996-01-01

    The ability to improve the capabilities and reliability of digital control systems in nuclear power stations to meet changing plant and personnel requirements is a formidable challenge. Many of these systems have high quality assurance standards that must be met to ensure adequate nuclear safety. Also many of these systems contain obsolete hardware along with software that is not easily transported to newer technology computer equipment. Combining modern technology upgrades into a system of obsolete hardware components is not an easy task. Lastly, as users become more accustomed to using modern technology computer systems in other areas of the station (e.g. information systems), their expectations of the capabilities of the plant systems increase. This paper will present three areas of the Darlington NGS fuel handling computer system that have been or are in the process of being upgraded to current technology components within the framework of an existing fuel handling control system. (author). 3 figs

  17. Evolution of the Darlington NGS fuel handling computer systems

    Energy Technology Data Exchange (ETDEWEB)

    Leung, V; Crouse, B [Ontario Hydro, Bowmanville (Canada). Darlington Nuclear Generating Station

    1997-12-31

    The ability to improve the capabilities and reliability of digital control systems in nuclear power stations to meet changing plant and personnel requirements is a formidable challenge. Many of these systems have high quality assurance standards that must be met to ensure adequate nuclear safety. Also many of these systems contain obsolete hardware along with software that is not easily transported to newer technology computer equipment. Combining modern technology upgrades into a system of obsolete hardware components is not an easy task. Lastly, as users become more accustomed to using modern technology computer systems in other areas of the station (e.g. information systems), their expectations of the capabilities of the plant systems increase. This paper will present three areas of the Darlington NGS fuel handling computer system that have been or are in the process of being upgraded to current technology components within the framework of an existing fuel handling control system. (author). 3 figs.

  18. A Perspective on Smart Process Manufacturing Research Challenges for Process Systems Engineers

    Directory of Open Access Journals (Sweden)

    Ian David Lockhart Bogle

    2017-04-01

    Full Text Available The challenges posed by smart manufacturing for the process industries and for process systems engineering (PSE researchers are discussed in this article. Much progress has been made in achieving plant- and site-wide optimization, but benchmarking would give greater confidence. Technical challenges confronting process systems engineers in developing enabling tools and techniques are discussed regarding flexibility and uncertainty, responsiveness and agility, robustness and security, the prediction of mixture properties and function, and new modeling and mathematics paradigms. Exploiting intelligence from big data to drive agility will require tackling new challenges, such as how to ensure the consistency and confidentiality of data through long and complex supply chains. Modeling challenges also exist, and involve ensuring that all key aspects are properly modeled, particularly where health, safety, and environmental concerns require accurate predictions of small but critical amounts at specific locations. Environmental concerns will require us to keep a closer track on all molecular species so that they are optimally used to create sustainable solutions. Disruptive business models may result, particularly from new personalized products, but that is difficult to predict.

  19. A Systematic Review of Wearable Patient Monitoring Systems - Current Challenges and Opportunities for Clinical Adoption.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Moqeem, Aasia A; Mirza, Farhaan; Lindén, Maria

    2017-07-01

    The aim of this review is to investigate barriers and challenges of wearable patient monitoring (WPM) solutions adopted by clinicians in acute, as well as in community, care settings. Currently, healthcare providers are coping with ever-growing healthcare challenges including an ageing population, chronic diseases, the cost of hospitalization, and the risk of medical errors. WPM systems are a potential solution for addressing some of these challenges by enabling advanced sensors, wearable technology, and secure and effective communication platforms between the clinicians and patients. A total of 791 articles were screened and 20 were selected for this review. The most common publication venue was conference proceedings (13, 54%). This review only considered recent studies published between 2015 and 2017. The identified studies involved chronic conditions (6, 30%), rehabilitation (7, 35%), cardiovascular diseases (4, 20%), falls (2, 10%) and mental health (1, 5%). Most studies focussed on the system aspects of WPM solutions including advanced sensors, wireless data collection, communication platform and clinical usability based on a specific area or disease. The current studies are progressing with localized sensor-software integration to solve a specific use-case/health area using non-scalable and 'silo' solutions. There is further work required regarding interoperability and clinical acceptance challenges. The advancement of wearable technology and possibilities of using machine learning and artificial intelligence in healthcare is a concept that has been investigated by many studies. We believe future patient monitoring and medical treatments will build upon efficient and affordable solutions of wearable technology.

  20. Design challenges for electronic medication administration record systems in residential aged care facilities: a formative evaluation.

    Science.gov (United States)

    Tariq, A; Lehnbom, E; Oliver, K; Georgiou, A; Rowe, C; Osmond, T; Westbrook, J

    2014-01-01

    Electronic medication administration record (eMAR) systems are promoted as a potential intervention to enhance medication safety in residential aged care facilities (RACFs). The purpose of this study was to conduct an in-practice evaluation of an eMAR being piloted in one Australian RACF before its roll out, and to provide recommendations for system improvements. A multidisciplinary team conducted direct observations of workflow (n=34 hours) in the RACF site and the community pharmacy. Semi-structured interviews (n=5) with RACF staff and the community pharmacist were conducted to investigate their views of the eMAR system. Data were analysed using a grounded theory approach to identify challenges associated with the design of the eMAR system. The current eMAR system does not offer an end-to-end solution for medication management. Many steps, including prescribing by doctors and communication with the community pharmacist, are still performed manually using paper charts and fax machines. Five major challenges associated with the design of eMAR system were identified: limited interactivity; inadequate flexibility; problems related to information layout and semantics; the lack of relevant decision support; and system maintenance issues. We suggest recommendations to improve the design of the eMAR system and to optimize existing workflows. Immediate value can be achieved by improving the system interactivity, reducing inconsistencies in data entry design and offering dedicated organisational support to minimise connectivity issues. Longer-term benefits can be achieved by adding decision support features and establishing system interoperability requirements with stakeholder groups (e.g. community pharmacies) prior to system roll out. In-practice evaluations of technologies like eMAR system have great value in identifying design weaknesses which inhibit optimal system use.

  1. Managing the Interoperability and Privacy of e-Health Systems as an Interdisciplinary Challenge

    Directory of Open Access Journals (Sweden)

    Alexandru Soceanu

    2016-10-01

    Full Text Available The growing number of patients with chronic diseases, the ageing population worldwide, the rapid increase in hospital costs and in the cost of care personnel as well as the achieving medical objectives "increase the patient quality of life and survival" face Europe with a huge challenge. One of the solutions for reaching these challenges in the future is the deployment of complex eHealth systems in support of all the healthcare aspects on the way between patient home and healthcare provider. In the last decade the European Commission (EC in cooperation with healthcare associations and standardization institutes announced large frameworks for supporting research and development of various components of the future eHealth systems. This may be considered as an immediate interdisciplinary opportunity for European researchers and developers to create jointly the spine of future healthcare systems. After a short introduction to eHealth architecture, interoperability, security and privacy the talk refers to the interdisciplinary solutions which approach these healthcare huge overall challenge. Two case studies will be addressed: a interdisciplinary partnership for conducting jointly European research concerning remote control and management of future wearable dialysis devices, and b ERASMUS supported international education programs for creating future interdisciplinary expert networks working on developing and implementing a better healthcare system.

  2. Security challenges in designing I and C systems for nuclear power plant

    International Nuclear Information System (INIS)

    Behera, Rajendra Prasad; Jayanthi, T.; Madhusoodanan, K.; Satya Murty, S.A.V.

    2016-01-01

    Geographically distributed instrumentation and control (I and C) systems in any nuclear power plant (NPP) facilitate the operator with remote access to real-time data and issue supervisory command to remote control devices deployed in the field. The increased connectivity to plant communication network has exposed I and C systems to security vulnerabilities both in terms of physical and logical access. For example, denial-of service and fault induction attack can disrupt the operation of I and C systems by delaying or blocking the flow of data through plant communication network. The design process of I and C system is quite challenging since an engineer has to consider both safety and security features implemented in hardware and software components of the system. This paper analyzes attack taxonomy based on available data and presents Security Tree Analysis (STA) technique towards building safe and secures I and C systems for Nuclear Power Plant. (author)

  3. Mental health system governance in Nigeria: challenges, opportunities and strategies for improvement.

    Science.gov (United States)

    Abdulmalik, J; Kola, L; Gureje, O

    2016-01-01

    A health systems approach to understanding efforts for improving health care services is gaining traction globally. A component of this approach focuses on health system governance (HSG), which can make or mar the successful implementation of health care interventions. Very few studies have explored HSG in low- and middle-income countries, including Nigeria. Studies focusing on mental health system governance, are even more of a rarity. This study evaluates the mental HSG of Nigeria with a view to understanding the challenges, opportunities and strategies for strengthening it. This study was conducted as part of the project, Emerging Mental Health Systems in Low and Middle Income Countries (Emerald). A multi-method study design was utilized to evaluate the mental HSG status of Nigeria. A situational analysis of the health policy and legal environment in the country was performed. Subsequently, 30 key informant interviews were conducted at national, state and district levels to explore the country's mental HSG. The existing policy, legislative and institutional framework for HSG in Nigeria reveals a complete exclusion of mental health in key health sector documents. The revised mental health policy is however promising. Using the Siddiqi framework categories, we identified pragmatic strategies for mental health system strengthening that include a consideration of existing challenges and opportunities within the system. The identified strategies provide a template for the subsequent activities of the Emerald Programme (and other interventions), towards strengthening the mental health system of Nigeria.

  4. Challenges in Modelling and Control of Offshore De-oiling Hydrocyclone Systems

    DEFF Research Database (Denmark)

    Løhndorf, Petar Durdevic; Pedersen, Simon; Yang, Zhenyu

    2017-01-01

    , and alternatively this task imposes a number of key control challenges. Specifically, there is much research to be performed in the direction of dynamic modelling and control of de-oiling hydrocyclone systems. The current solutions rely heavily on empirical trial-and-error approaches. This paper gives a brief......Offshore de-oiling installations are facing an increasing challenge with regards to removing oil residuals from produced water prior to discharge into the ocean. The de-oiling of produced water is initially achieved in the primary separation processes using gravity-based multi-phase separators...... in the produced water before it can be discharged into the ocean. The popularity of hydrocyclone technology in the offshore oil and gas industry is mainly due to its rugged design and low maintenance requirements. However, to operate and control this type of system in an efficient way is far less simple...

  5. IT-security challenges in IoT environments and autonomous systems

    Science.gov (United States)

    Heun, Ulrich

    2017-05-01

    Internet of Things will open the digital world for future services working across company borders. Together with autonomous systems intelligent things will communicate and work together without direct influence of human technicians or service managers. IT-security will become one of the most important challenges to ensure a stable service performance and to provide a trustful environment to let people use such service without any concerns regarding data privacy and eligibility of the outcomes.

  6. Finding food: Issues and challenges in using Geographic Information Systems to measure food access

    OpenAIRE

    Forsyth, Ann; Lytle, Leslie; Riper, David Van

    2010-01-01

    A significant amount of travel is undertaken to find food. This paper examines challenges in measuring access to food using Geographic Information Systems (GIS), important in studies of both travel and eating behavior. It compares different sources of data available including fieldwork, land use and parcel data, licensing information, commercial listings, taxation data, and online street-level photographs. It proposes methods to classify different kinds of food sales places in a way that says...

  7. Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge

    DEFF Research Database (Denmark)

    Salvesen, Øyvind; Reiten, Malin R; Heegaard, Peter M. H.

    2016-01-01

    observed peaking at 2 h, corroborating the increasing evidence that ISGs respond immediately to bacterial endotoxins. A slower response was manifested by four extrahepatic acute phase proteins (APP) (SAA3, HP, LF and LCN2) reaching maximum levels at 5 h. We report an immediate induction of ISGs...... insights into the dynamic regulation of innate immune genes, as well as raising new questions regarding the importance of ISGs and extrahepatic APPs in leukocytes after systemic endotoxin challenge....

  8. Challenges facing the distribution of an artificial-intelligence-based system for nursing.

    Science.gov (United States)

    Evans, S

    1985-04-01

    The marketing and successful distribution of artificial-intelligence-based decision-support systems for nursing face special barriers and challenges. Issues that must be confronted arise particularly from the present culture of the nursing profession as well as the typical organizational structures in which nurses predominantly work. Generalizations in the literature based on the limited experience of physician-oriented artificial intelligence applications (predominantly in diagnosis and pharmacologic treatment) must be modified for applicability to other health professions.

  9. Analysis of Aviation Safety Reporting System Incident Data Associated With the Technical Challenges of the Vehicle Systems Safety Technology Project

    Science.gov (United States)

    Withrow, Colleen A.; Reveley, Mary S.

    2014-01-01

    This analysis was conducted to support the Vehicle Systems Safety Technology (VSST) Project of the Aviation Safety Program (AVsP) milestone VSST4.2.1.01, "Identification of VSST-Related Trends." In particular, this is a review of incident data from the NASA Aviation Safety Reporting System (ASRS). The following three VSST-related technical challenges (TCs) were the focus of the incidents searched in the ASRS database: (1) Vechicle health assurance, (2) Effective crew-system interactions and decisions in all conditions; and (3) Aircraft loss of control prevention, mitigation, and recovery.

  10. [Challenges of an integrative and personalised health care for health economics and the insurance system].

    Science.gov (United States)

    Schoch, Goentje-Gesine; Würdemann, E

    2014-11-01

    "Stratifying medicine" is a topic of increasing importance in the public health system. There are several questions related to "stratifying medicine". This paper reconsiders definitions, opportunities and risks related to "stratifying medicine" as well as the main challenges of "stratifying medicine" from the perspective of a public health insurance. The application of the term and the definition are important points to discuss. Terms such as "stratified medicine", "personalised medicine" or "individualised medicine" are used. The Techniker Krankenkasse prefers "stratifying medicine", because it usually means a medicine that tailors therapy to specific groups of patients by biomarkers. OPPORTUNITIES AND RISKS: "Stratifying medicine" is associated with various hopes, e. g., the avoidance of ineffective therapies and early detection of diseases. But "stratifying medicine" also carries risks, such as an increase in the number of cases by treatment of disease risks, a duty for health and the weakening of the criteria of evidence-based medicine. The complexity of "stratifying medicine" is a big challenge for all involved parties in the health system. A lot of interrelations are still not completely understood. So the statutory health insurance faces the challenge of making innovative therapy concepts accessible in a timely manner to all insured on the one hand but on the other hand also to protect the community from harmful therapies. Information and advice to patients related to "stratifying medicine" is of particular importance. The equitable distribution of fees for diagnosis and counselling presents a particular challenge. The solidarity principle of public health insurance may be challenged by social and ethical issues of "stratifying medicine". "Stratifying medicine" offers great potential to improve medical care. However, false hopes must be avoided. Providers and payers should measure chances and risks of "stratifying medicine" together for the welfare of the

  11. A suite of benchmark and challenge problems for enhanced geothermal systems

    Energy Technology Data Exchange (ETDEWEB)

    White, Mark; Fu, Pengcheng; McClure, Mark; Danko, George; Elsworth, Derek; Sonnenthal, Eric; Kelkar, Sharad; Podgorney, Robert

    2017-11-06

    A diverse suite of numerical simulators is currently being applied to predict or understand the performance of enhanced geothermal systems (EGS). To build confidence and identify critical development needs for these analytical tools, the United States Department of Energy, Geothermal Technologies Office sponsored a Code Comparison Study (GTO-CCS), with participants from universities, industry, and national laboratories. A principal objective for the study was to create a community forum for improvement and verification of numerical simulators for EGS modeling. Teams participating in the study were those representing U.S. national laboratories, universities, and industries, and each team brought unique numerical simulation capabilities to bear on the problems. Two classes of problems were developed during the study, benchmark problems and challenge problems. The benchmark problems were structured to test the ability of the collection of numerical simulators to solve various combinations of coupled thermal, hydrologic, geomechanical, and geochemical processes. This class of problems was strictly defined in terms of properties, driving forces, initial conditions, and boundary conditions. The challenge problems were based on the enhanced geothermal systems research conducted at Fenton Hill, near Los Alamos, New Mexico, between 1974 and 1995. The problems involved two phases of research, stimulation, development, and circulation in two separate reservoirs. The challenge problems had specific questions to be answered via numerical simulation in three topical areas: 1) reservoir creation/stimulation, 2) reactive and passive transport, and 3) thermal recovery. Whereas the benchmark class of problems were designed to test capabilities for modeling coupled processes under strictly specified conditions, the stated objective for the challenge class of problems was to demonstrate what new understanding of the Fenton Hill experiments could be realized via the application of

  12. MAINTAINING LONG-TERM MANAGEMENT: Herbicide-resistant weeds challenge some signature cropping systems

    Directory of Open Access Journals (Sweden)

    Bradley D. Hanson

    2014-10-01

    Full Text Available Invasive and endemic weeds pose recurring challenges for California land managers. The evolution of herbicide resistance in several species has imposed new challenges in some cropping systems, and these issues are being addressed by UC Cooperative Extension farm advisors, specialists and faculty. There are currently 24 unique herbicide-resistant weed biotypes in the state, dominated by grasses and sedges in flooded rice systems and, more recently, glyphosate-resistant broadleaf and grass weeds in tree and vine systems, roadsides and glyphosate-tolerant field crops. Weed scientists address these complex issues using approaches ranging from basic physiology and genetics research to applied research and extension efforts in grower fields throughout the state. Although solutions to herbicide resistance are not simple and are affected by many biological, economic, regulatory and social factors, California stakeholders need information, training and solutions to address new weed management problems as they arise. Coordinated efforts conducted under the Endemic and Invasive Pests and Disease Strategic Initiative directly address weed management challenges in California's agricultural industries.

  13. Changing societies and four tasks of schooling: Challenges for strongly differentiated educational systems

    Science.gov (United States)

    van de Werfhorst, Herman G.

    2014-05-01

    Changing labour markets, increased calls for selection and excellence, and increased diversity and individualisation have repercussions on how educational systems can prepare youth for work, optimise knowledge production, achieve equality of opportunity, and socialise students into active civic engagement. This paper discusses four central tasks of schooling and examines to what extent societal developments challenge education policy to deliver on the tasks at hand. Particular attention is given to the challenges Europe's strongly diversified educational systems are currently facing. Both the Netherlands and Germany, for example, have been offering vocationally-oriented pathways alongside traditional academic higher education for some time. But today's ongoing changes in job descriptions, mainly due to ever-accelerating technological developments, are causing a risk of skills obsolescence which can only be avoided by continuous upskilling and/or reskilling of a sufficiently flexible workforce. Overcoming differences of intelligence as well as differences of diverse socioeconomic, ethnic and linguistic backgrounds by way of education is another challenge, as is fostering "soft" skills and political awareness. This paper investigates the effectiveness of current education systems in preparing citizens for a functioning modern society.

  14. Cloud service performance evaluation: status, challenges, and opportunities – a survey from the system modeling perspective

    Directory of Open Access Journals (Sweden)

    Qiang Duan

    2017-05-01

    Full Text Available With rapid advancement of Cloud computing and networking technologies, a wide spectrum of Cloud services have been developed by various providers and utilized by numerous organizations as indispensable ingredients of their information systems. Cloud service performance has a significant impact on performance of the future information infrastructure. Thorough evaluation on Cloud service performance is crucial and beneficial to both service providers and consumers; thus forming an active research area. Some key technologies for Cloud computing, such as virtualization and the Service-Oriented Architecture (SOA, bring in special challenges to service performance evaluation. A tremendous amount of effort has been put by the research community to address these challenges and exciting progress has been made. Among the work on Cloud performance analysis, evaluation approaches developed with a system modeling perspective play an important role. However, related works have been reported in different sections of the literature; thus lacking a big picture that shows the latest status of this area. The objectives of this article is to present a survey that reflects the state of the art of Cloud service performance evaluation from the system modeling perspective. This articles also examines open issues and challenges to the surveyed evaluation approaches and identifies possible opportunities for future research in this important field.

  15. Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities.

    Science.gov (United States)

    Li, Ling; Hu, Shuo; Chen, Xiaoyuan

    2018-07-01

    In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-associated) genome editing systems have become one of the most robust platforms in basic biomedical research and therapeutic applications. To date, efficient in vivo delivery of the CRISPR/Cas9 system to the targeted cells remains a challenge. Although viral vectors have been widely used in the delivery of the CRISPR/Cas9 system in vitro and in vivo, their fundamental shortcomings, such as the risk of carcinogenesis, limited insertion size, immune responses and difficulty in large-scale production, severely limit their further applications. Alternative non-viral delivery systems for CRISPR/Cas9 are urgently needed. With the rapid development of non-viral vectors, lipid- or polymer-based nanocarriers have shown great potential for CRISPR/Cas9 delivery. In this review, we analyze the pros and cons of delivering CRISPR/Cas9 systems in the form of plasmid, mRNA, or protein and then discuss the limitations and challenges of CRISPR/Cas9-based genome editing. Furthermore, current non-viral vectors that have been applied for CRISPR/Cas9 delivery in vitro and in vivo are outlined in details. Finally, critical obstacles for non-viral delivery of CRISPR/Cas9 system are highlighted and promising strategies to overcome these barriers are proposed. Published by Elsevier Ltd.

  16. Challenges and opportunities of using recommender systems for personalized health education.

    Science.gov (United States)

    Fernandez-Luque, Luis; Karlsen, Randi; Vognild, Lars K

    2009-01-01

    The use of computers in health education started more than a decade ago, mainly for tailoring health educational resources. Nowadays, many of the computer-tailoring health education systems are using the Internet for delivering different types of health education. Traditionally, these systems are designed for a specific health problem, with a predefined library of educational resources. These systems do not take advantage of the increasing amount of educational resources available on the Internet. One of the reasons is that the high availability of content is making it more difficult to find the relevant one. The problem of information overload has been addressed for many years in the field of recommender systems. This paper is focused on the challenges and opportunities of merging recommender systems with personalized health education. It also discusses the usage of social networks and semantic technologies within this approach.

  17. Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

    Science.gov (United States)

    Singh, Mrityunjay

    2010-01-01

    Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

  18. Greenlandic water and sanitation-a context oriented analysis of system challenges towards local sustainable development.

    Science.gov (United States)

    Hendriksen, Kåre; Hoffmann, Birgitte

    2017-08-28

    Today, as Greenland focuses on more economic and cultural autonomy, the continued development of societal infrastructure systems is vital. At the same time, pressure is put on the systems by a lack of financial resources and locally based professional competences as well as new market-based forms of organization. Against this background, the article discusses the challenges facing Greenland's self-rule in relation to further develop the existing water and wastewater systems so that they can contribute to the sustainable development of Greenland. The article reviews the historical development of the water supply and wastewater system. This leads to an analysis of the sectorisation, which in recent decades has reorganized the Greenlandic infrastructures, and of how this process is influencing local sustainable development. The article discusses the socio-economic and human impacts and points to the need for developing the water and sanitation system to support not only hygiene and health, but also local sustainable development.

  19. The Diagnostic Challenge Competition: Probabilistic Techniques for Fault Diagnosis in Electrical Power Systems

    Science.gov (United States)

    Ricks, Brian W.; Mengshoel, Ole J.

    2009-01-01

    Reliable systems health management is an important research area of NASA. A health management system that can accurately and quickly diagnose faults in various on-board systems of a vehicle will play a key role in the success of current and future NASA missions. We introduce in this paper the ProDiagnose algorithm, a diagnostic algorithm that uses a probabilistic approach, accomplished with Bayesian Network models compiled to Arithmetic Circuits, to diagnose these systems. We describe the ProDiagnose algorithm, how it works, and the probabilistic models involved. We show by experimentation on two Electrical Power Systems based on the ADAPT testbed, used in the Diagnostic Challenge Competition (DX 09), that ProDiagnose can produce results with over 96% accuracy and less than 1 second mean diagnostic time.

  20. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2015-10-01

    Full Text Available Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX, are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

  1. Public Health System in Brazil nowadays: challenges for its operation and funding

    Directory of Open Access Journals (Sweden)

    Alethele de Oliveira Santos

    2016-09-01

    Full Text Available This paper has the aim to revisit the theme of the brazilian public health system from the perspective of its operation and funding of its actions and services, analyzing some of the main obstacles to its effectiveness. Endowed with its own logic of organization, planning and funding of its actions and services, the Brazilian Unified Health System (SUS finds barriers to its sustainability when it comes to funding and the judicialization of health. Historical under-funding worsened by the economic and political crisis the country currently faces plus the increase in casuistic judicial decisions that prioritize the individual logic over the collective right have produced serious shocks in the system. These are just some of the challenges to an effective public health system. This is why the work of public bodies must be responsible and always take into consideration the collective dimension of the right to health under penalty of causing the collapse of the public health system altogether.

  2. Challenges to China's transition to a low carbon electricity system

    Energy Technology Data Exchange (ETDEWEB)

    Kahrl, Fredrich, E-mail: fkahrl@berkeley.edu [Energy and Resources Group, University of California, Berkeley, 310 Barrows Hall, Berkeley, CA 94720 (United States); Williams, Jim [Energy and Environmental Economics, Inc., 101 Montgomery Street, 16th Floor, San Francisco, CA 94104 (United States); Monterey Institute of International Studies, 460 Pierce Street, Monterey, CA 93940 (United States); Ding Jianhua [Energy and Environmental Economics, Inc., 101 Montgomery Street, 16th Floor, San Francisco, CA 94104 (United States); Hu Junfeng [School of Economics and Business Administration, North China Electric Power University, Beijing 102206 (China)

    2011-07-15

    We examine the challenges to China's transition to a low carbon electricity system, in which renewable energy would play a significant role. China's electricity system currently lacks the flexibility in planning, operations, and pricing to respond to conflicting pressures from demand growth, rising costs, and environmental mandates in a way that simultaneously maintains reliability, decarbonizes the system, and keeps prices within acceptable bounds. Greater flexibility crucially requires the ability to more systematically and transparently manage and allocate costs. This will require re-orientating sector institutions still rooted in central planning, and strengthening independent regulation. Some of the necessary changes require fundamental political and legal reforms beyond the scope of energy policy. However, the system's flexibility can still be increased through the development of traditional planning and regulatory tools and approaches, such as an avoided cost basis for energy efficiency investments, more integrated planning to improve the coordination of generation, transmission, and demand-side investments, and a transparent ratemaking process. The judicious application of OECD electricity sector experience and skills can support these developments. - Research Highlights: > China's electricity system currently lacks the flexibility to integrate renewables and reduce CO{sub 2} emissions on a large scale at an acceptable cost and level of reliability. > The challenges to increased flexibility are more institutional than technological. > Chinese government agencies need new approaches to basic power system planning and ratemaking. > OECD countries can help address these challenges through the transfer of 'soft' technologies.

  3. A Systematic Review of Wearable Systems for Cancer Detection: Current State and Challenges.

    Science.gov (United States)

    Ray, Partha Pratim; Dash, Dinesh; De, Debashis

    2017-10-02

    Rapid growth of sensor and computing platforms have introduced the wearable systems. In recent years, wearable systems have led to new applications across all medical fields. The aim of this review is to present current state-of-the-art approach in the field of wearable system based cancer detection and identify key challenges that resist it from clinical adoption. A total of 472 records were screened and 11 were finally included in this study. Two types of records were studied in this context that includes 45% research articles and 55% manufactured products. The review was performed per PRISMA guidelines where considerations was given to records that were published or reported between 2009 and 2017. The identified records included 4 cancer detecting wearable systems such as breast cancer (36.3%), skin cancer (36.3%), prostate cancer (18.1%), and multi-type cancer (9%). Most works involved sensor based smart systems comprising of microcontroller, Bluetooth module, and smart phone. Few demonstrated Ultra-Wide Band (i.e. UWB) antenna based wearable systems. Skin cancer detecting wearable systems were most comprehensible ones. The current works are gradually progressing with seamless integration of sensory units along with smart networking. However, they lack in cloud computing and long-range communication paradigms. Artificial intelligence and machine learning are key ports that need to be attached with current wearable systems. Further, clinical inertia, lack of awareness, and high cost are altogether pulling back the actual growth of such system. It is well comprehended that upon sincere orientation of all identified challenges, wearable systems would emerge as vital alternative to futuristic cancer detection.

  4. Drivers and challenges for implementing ISO 14001 environmental management systems in an emerging Gulf Arab country.

    Science.gov (United States)

    Waxin, Marie-France; Knuteson, Sandra L; Bartholomew, Aaron

    2017-11-13

    Worldwide, ISO 14001 certification for organizations has become the norm, but the Arab world accounts for an insignificant portion of all the certified organizations. There is a dearth of research on environmental management systems (EMS) in Arab and emerging countries and in public organizations. The objectives of this research are to: (1) examine the key drivers and challenges related to implementation of ISO 14001 certified EMS in the United Arab Emirates, an emerging Arab country and (2) compare and contrast these drivers and challenges between private and public organizations. We adopt an explorative, qualitative methodology, using semi-structured interviews with environmental managers in 11 organizations (6 private and 5 public) from different industrial sectors. Drivers of EMS certification were mostly similar between private and public organizations, with some differences. Compliance with regulations and standards, and increasing environmental performance were the main drivers for ISO 14001 certification in both private and public organizations. Commitment to sustainability was more important for public organizations. Cost reduction, competitors, leadership commitment and customers' demands were shared drivers, but more stressed by private organizations. Local community and employees' pressures were reported by private organizations only. The challenges to ISO 14001 implementation were similar for private and public organizations. They were: a lack of qualified human resources, practical challenges associated with implementation, a lack of regulations, a lack of support from management, and high costs. Our findings have implications for managers, academics, consultants, and policy makers in the UAE and other emerging markets.

  5. Achieving Closure for Bioregenerative Life Support Systems: Engineering and Ecological Challenges, Research Opportunities

    Science.gov (United States)

    Dempster, William; Allen, John P.

    Closed systems are desirable for a number of purposes: space life support systems where precious life-supporting resources need to be kept inside; biospheric systems; where global ecological pro-cesses can be studied in great detail and testbeds where research topics requiring isolation from the outside (e.g. genetically modified organisms; radioisotopes) can be studied in isolation from the outside environment and where their ecological interactions and fluxes can be studied. But to achieve and maintain closure raises both engineering and ecological challenges. Engineering challenges include methods of achieving closure for structures of different materials, and devel-oping methods of allowing energy (for heating and cooling) and information transfer through the materially closed structure. Methods of calculating degree of closure include measuring degradation rates of inert trace gases introduced into the system. An allied problem is devel-oping means of locating where leaks are located so that they may be repaired and degree of closure maintained. Once closure is achieved, methods of dealing with the pressure differen-tials between inside and outside are needed: from inflatable structures which might adjust to the pressure difference to variable volume chambers attached to the life systems component. These issues are illustrated through the engineering employed at Biosphere 2, the Biosphere 2 Test Module and the Laboratory Biosphere and a discussion of methods used by other closed ecological system facility engineers. Ecological challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro-and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet and recycling nutrients and maintaining soil fertility, healthy air and

  6. Challenges of implementing economic model predictive control strategy for buildings interacting with smart energy systems

    DEFF Research Database (Denmark)

    Zong, Yi; Böning, Georg Martin; Santos, Rui Mirra

    2016-01-01

    ) strategy for energy management in smart buildings, which can act as active users interacting with smart energy systems. The challenges encountered during the implementation of EMPC for active demand side management are investigated in detail in this paper. A pilot testing study shows energy savings......When there is a high penetration of renewables in the energy system, it requires proactive control of large numbers of distributed demand response resources to maintain the system’s reliability and improve its operational economics. This paper presents the Economic Model Predictive Control (EMPC...

  7. Socio-Hydrology: Conceptual and Methodological Challenges in the Bidirectional Coupling of Human and Water Systems

    Science.gov (United States)

    Scott, C. A.

    2014-12-01

    This presentation reviews conceptual advances in the emerging field of socio-hydrology that focuses on coupled human and water systems. An important current challenge is how to better couple the bidirectional influences between human and water systems, which lead to emergent dynamics. The interactions among (1) the structure and dynamics of systems with (2) human values and norms lead to (3) outcomes, which in turn influence subsequent interactions. Human influences on hydrological systems are relatively well understood, chiefly resulting from developments in the field of water resources. The ecosystem-service concept of cultural value has expanded understanding of decision-making beyond economic rationality criteria. Hydrological impacts on social processes are less well developed conceptually, but this is changing with growing attention to vulnerability, adaptation, and resilience, particularly in the face of climate change. Methodological limitations, especially in characterizing the range of human responses to hydrological events and drivers, still pose challenges to modeling bidirectional human-water influences. Evidence from multiple case studies, synthesized in more broadly generic syndromes, helps surmount these methodological limitations and offers the potential to improve characterization and quantification of socio-hydrological systems.

  8. Community-Based Disaster Risk Management in the Philippines: Achievements and Challenges of the Purok System

    Directory of Open Access Journals (Sweden)

    Angelina Matthies

    2017-06-01

    Full Text Available The purok system in the Philippines is promoted as a voluntary self-organization at the sub-village level which strengthens community resilience to natural hazards. In 2011, the system received the UN Sasakawa Award and gained prominence among the practitioner community. Based on a qualitative study in the municipality of San Francisco (Cebu province from December 2014 to March 2015, the article elaborates on the achievements and challenges of the purok system. Striking merits encompass efficient and effective information dissemination and evacuation measurements between all levels of political administration that stem from the system’s remarkable enforcement of human and social capital. This is underpinned by a clear determination of roles and responsibility that is subsumed under the concept of accountability. However, the purok system faces internal challenges of maintenance and implies profound conceptual ambiguities regarding the notion of voluntarism and capabilities that favor clientelism. Nevertheless, the purok system clearly distinguishes itself from conventional community-based disaster risk management practices and implies potentials that are highly beneficial for strengthening resilience in disaster prone areas.

  9. A status report on artificial lift systems and challenges in North Dakota horizontal completions

    Energy Technology Data Exchange (ETDEWEB)

    Fangmeier, K. [Amerada Hess Corp., ND (United States)

    2005-07-01

    Partially pressure depleted reservoirs and unfavorable horizontal flow geometries can impact artificial lift designs and diagnostics. In addition, terrain slugging, drilling fines, high gas volume fractions, H{sub 2}S gas and high bottom hole temperatures also pose challenges. This paper provides an overview of various systems utilized by Amerada Hess, a company which examines methods of reducing gas lift gas volumes to achieve maximum flow. A description of naturally fractured reservoirs and limited natural fractures was provided. A comparison was presented between the original conditions at Beaver Lodge Madison and existing conditions with horizontal development. Various artificial lift challenges were examined. It was suggested that high volume lift utilizing gas lift was the preferred artificial lift system for high volume wells. It was noted that downhole sensors can be used as an indicator of potential run life. However, reliability is limited by downhole operating temperatures and electrical ground faults. A comparison of friendly and unfriendly flow systems was presented, as well as a gas lift pressure chart. A summary of average gas volume systems was provided as well as an example of a response to increase drawdown. Examples of downhole Electric Submersible Pump (ESP) sensors were provided, as well as possible flowing pressure profiles in horizontal completion because of the constraints of lift capacity. It was concluded that a single point injection and proven gas lift system is the next step in high volume lift strategy. 2 tabs, 16 figs.

  10. [Sustainability and excellence of the Catalan health system. New paradigms, challenges and responses].

    Science.gov (United States)

    Fernández i Alegre, Roser; Argenter i Giralt, Miquel; Rodríguez i Guasch, Xavier

    2015-11-01

    The aim of a health system and the priority of any government is to anticipate problems before they appear, provide an innovative response to these new needs and healthcare models, improve access of the general public and patients to health care, especially care for the most vulnerable groups, improve healthcare results and implement the structural reforms necessary to maintain a viable and sustainable quality public healthcare system for everyone. In the current environment, health systems are facing new economic, demographic, care, social, technological and political paradigms to which health policy must respond. Faced with these challenges, health systems, especially in the case of Catalonia, are challenged to take decisions on how best to approach the implementation of structural reform designed to facilitate the necessary economic and fiscal sustainability in the service of fresh and innovative health policies and patient-centred care within a system marked by excellence and equity. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  11. Fall Prediction and Prevention Systems: Recent Trends, Challenges, and Future Research Directions

    Directory of Open Access Journals (Sweden)

    Ramesh Rajagopalan

    2017-11-01

    Full Text Available Fall prediction is a multifaceted problem that involves complex interactions between physiological, behavioral, and environmental factors. Existing fall detection and prediction systems mainly focus on physiological factors such as gait, vision, and cognition, and do not address the multifactorial nature of falls. In addition, these systems lack efficient user interfaces and feedback for preventing future falls. Recent advances in internet of things (IoT and mobile technologies offer ample opportunities for integrating contextual information about patient behavior and environment along with physiological health data for predicting falls. This article reviews the state-of-the-art in fall detection and prediction systems. It also describes the challenges, limitations, and future directions in the design and implementation of effective fall prediction and prevention systems.

  12. Embedded and real-time vehicle detection system for challenging on-road scenes

    Science.gov (United States)

    Gu, Qin; Yang, Jianyu; Kong, Lingjiang; Yan, Wei Qi; Klette, Reinhard

    2017-06-01

    Vehicle detection is an important topic for advanced driver-assistance systems. This paper proposes an adaptive approach for an embedded system by focusing on monocular vehicle detection in real time, also aiming at being accurate under challenging conditions. Scene classification is accomplished by using a simplified convolution neural network with hypothesis generation by SoftMax regression. The output is consequently taken into account to optimize detection parameters for hypothesis generation and testing. Thus, we offer a sample-reorganization mechanism to improve the performance of vehicle hypothesis verification. A hypothesis leap mechanism is in use to improve the operating efficiency of the on-board system. A practical on-road test is employed to verify vehicle detection (i.e., accuracy) and also the performance of the designed on-board system regarding speed.

  13. Fall Prediction and Prevention Systems: Recent Trends, Challenges, and Future Research Directions.

    Science.gov (United States)

    Rajagopalan, Ramesh; Litvan, Irene; Jung, Tzyy-Ping

    2017-11-01

    Fall prediction is a multifaceted problem that involves complex interactions between physiological, behavioral, and environmental factors. Existing fall detection and prediction systems mainly focus on physiological factors such as gait, vision, and cognition, and do not address the multifactorial nature of falls. In addition, these systems lack efficient user interfaces and feedback for preventing future falls. Recent advances in internet of things (IoT) and mobile technologies offer ample opportunities for integrating contextual information about patient behavior and environment along with physiological health data for predicting falls. This article reviews the state-of-the-art in fall detection and prediction systems. It also describes the challenges, limitations, and future directions in the design and implementation of effective fall prediction and prevention systems.

  14. Testing Challenges of Maritime Safety and Security Systems-of-Systems

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.; Gross, H.G.

    2008-01-01

    Preprint of paper published in: TAIC PART 2008: Testing: Academic & Industrial Conference, Practice and Research Techniques, 29-31 August 2008; doi:10.1109/TAIC-PART.2008.14 Maritime Safety and Security systems represent a novel kind of large-scale distributed component-based systems in which the

  15. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

    Science.gov (United States)

    Vaquero, Juan José; Kinahan, Paul

    2017-01-01

    Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges. PMID:26643024

  16. Sensor Network Middleware for Cyber-Physical Systems: Opportunities and Challenges

    Science.gov (United States)

    Singh, G.

    2015-12-01

    Wireless Sensor Network middleware typically provides abstractions for common tasks such as atomicity, synchronization and communication with the intention of isolating the developers of distributed applications from lower-level details of the underlying platforms. Developing middleware to meet the performance constraints of applications is an important challenge. Although one would like to develop generic middleware services which can be used in a variety of different applications, efficiency considerations often force developers to design middleware and algorithms customized to specific operational contexts. This presentation will discuss techniques to design middleware that is customizable to suit the performance needs of specific applications. We also discuss the challenges poised in designing middleware for pervasive sensor networks and cyber-physical systems with specific focus on environmental monitoring.

  17. The deployed medical director: managing the challenges of a complex trauma system.

    Science.gov (United States)

    Mahoney, P F; Hodgetts, T J; Hicks, I

    2011-09-01

    Contemporary combat casualty care has never been more sophisticated or effective, which is matched by an unprecedented level of clinical complexity. The management of this complexity has demanded the evolution of a more direct clinical leadership model in the field hospital: the Deployed Medical Director (DMD). The DMD has a central co-ordinating role in reducing the friction generated by individuals' unfamiliarity in a rapidly developing clinical environment that has diverged from the NHS; in cementing interoperability within a multinational medical treatment facility working at high intensity; and in maintaining and developing the highest clinical standards within the deployed trauma system. This article describes the evolution of the DMD role and illustrates the challenges through a series of vignettes. Particular emphasis is given to the organisational risk that the role carries through necessary ethical choices, the requirement to integrate multi-national cultural differences and the challenge of dealing with interpersonal frictions amongst senior staff.

  18. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.

    Science.gov (United States)

    Vaquero, Juan José; Kinahan, Paul

    2015-01-01

    Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.

  19. Next-Generation Climate Modeling Science Challenges for Simulation, Workflow and Analysis Systems

    Science.gov (United States)

    Koch, D. M.; Anantharaj, V. G.; Bader, D. C.; Krishnan, H.; Leung, L. R.; Ringler, T.; Taylor, M.; Wehner, M. F.; Williams, D. N.

    2016-12-01

    We will present two examples of current and future high-resolution climate-modeling research that are challenging existing simulation run-time I/O, model-data movement, storage and publishing, and analysis. In each case, we will consider lessons learned as current workflow systems are broken by these large-data science challenges, as well as strategies to repair or rebuild the systems. First we consider the science and workflow challenges to be posed by the CMIP6 multi-model HighResMIP, involving around a dozen modeling groups performing quarter-degree simulations, in 3-member ensembles for 100 years, with high-frequency (1-6 hourly) diagnostics, which is expected to generate over 4PB of data. An example of science derived from these experiments will be to study how resolution affects the ability of models to capture extreme-events such as hurricanes or atmospheric rivers. Expected methods to transfer (using parallel Globus) and analyze (using parallel "TECA" software tools) HighResMIP data for such feature-tracking by the DOE CASCADE project will be presented. A second example will be from the Accelerated Climate Modeling for Energy (ACME) project, which is currently addressing challenges involving multiple century-scale coupled high resolution (quarter-degree) climate simulations on DOE Leadership Class computers. ACME is anticipating production of over 5PB of data during the next 2 years of simulations, in order to investigate the drivers of water cycle changes, sea-level-rise, and carbon cycle evolution. The ACME workflow, from simulation to data transfer, storage, analysis and publication will be presented. Current and planned methods to accelerate the workflow, including implementing run-time diagnostics, and implementing server-side analysis to avoid moving large datasets will be presented.

  20. The plant as metaorganism and research on next-generation systemic pesticides - Prospects and challenges

    Directory of Open Access Journals (Sweden)

    Zisis Vryzas

    2016-12-01

    Full Text Available Systemic pesticides (SP are usually recommended for soil treatments and as seed coating agents and are taken up from the soil by involving various plant-mediated processes, physiological and morphological attributes of the root systems. Microscopic insights and next-generation sequencing combined with bioinformatics allow us now to identify new functions and interactions of plant-associated bacteria and perceive plants as meta-organisms. Host symbiotic, rhizo-epiphytic, endophytic microorganisms and their functions on plants have not been studied yet in accordance with uptake, tanslocation and action of pesticides. Root tips exudates mediated by rhizobacteria could modify the uptake of specific pesticides while bacterial ligands and enzymes can affect metabolism and fate of pesticide within plant. Over expression of specific proteins in cell membrane can also modify pesticide influx in roots. Moreover, proteins and other membrane compartments are usually involved in pesticide modes of action and resistance development. In this article it is discussed what is known of the physiological attributes including apoplastic, symplastic and trans-membane transport of systemic pesticides in accordance with the intercommunication dictated by plant-microbe, cell to cell and intracellular signaling. Prospects and challenges for uptake, translocation, storage, exudation, metabolism and action of systemic pesticides are given through the prism of new insights of plant microbiome. Interactions of soil applied pesticides with physiological processes, plant root exudates and plant microbiome are summarized to scrutinize challenges for the next-generation pesticides.

  1. u-Healthcare system: state-of-the-art review and challenges.

    Science.gov (United States)

    Touati, Farid; Tabish, Rohan

    2013-06-01

    With the increase of an ageing population and chronic diseases, society becomes more health conscious and patients become "health consumers" looking for better health management. People's perception is shifting towards patient-centered, rather than the classical, hospital-centered health services which has been propelling the evolution of telemedicine research from the classic e-Health to m-Health and now is to ubiquitous healthcare (u-Health). It is expected that mobile & ubiquitous Telemedicine, integrated with Wireless Body Area Network (WBAN), have a great potential in fostering the provision of next-generation u-Health. Despite the recent efforts and achievements, current u-Health proposed solutions still suffer from shortcomings hampering their adoption today. This paper presents a comprehensive review of up-to-date requirements in hardware, communication, and computing for next-generation u-Health systems. It compares new technological and technical trends and discusses how they address expected u-Health requirements. A thorough survey on various worldwide recent system implementations is presented in an attempt to identify shortcomings in state-of-the art solutions. In particular, challenges in WBAN and ubiquitous computing were emphasized. The purpose of this survey is not only to help beginners with a holistic approach toward understanding u-Health systems but also present to researchers new technological trends and design challenges they have to cope with, while designing such systems.

  2. The health and health system of South Africa: historical roots of current public health challenges.

    Science.gov (United States)

    Coovadia, Hoosen; Jewkes, Rachel; Barron, Peter; Sanders, David; McIntyre, Diane

    2009-09-05

    The roots of a dysfunctional health system and the collision of the epidemics of communicable and non-communicable diseases in South Africa can be found in policies from periods of the country's history, from colonial subjugation, apartheid dispossession, to the post-apartheid period. Racial and gender discrimination, the migrant labour system, the destruction of family life, vast income inequalities, and extreme violence have all formed part of South Africa's troubled past, and all have inexorably affected health and health services. In 1994, when apartheid ended, the health system faced massive challenges, many of which still persist. Macroeconomic policies, fostering growth rather than redistribution, contributed to the persistence of economic disparities between races despite a large expansion in social grants. The public health system has been transformed into an integrated, comprehensive national service, but failures in leadership and stewardship and weak management have led to inadequate implementation of what are often good policies. Pivotal facets of primary health care are not in place and there is a substantial human resources crisis facing the health sector. The HIV epidemic has contributed to and accelerated these challenges. All of these factors need to be addressed by the new government if health is to be improved and the Millennium Development Goals achieved in South Africa.

  3. Cross-terminology mapping challenges: A demonstration using medication terminological systems

    Science.gov (United States)

    Saitwal, Himali; Qing, David; Jones, Stephen; Bernstam, Elmer; Chute, Christopher G.; Johnson, Todd R.

    2015-01-01

    Standardized terminological systems for biomedical information have provided considerable benefits to biomedical applications and research. However, practical use of this information often requires mapping across terminological systems—a complex and time-consuming process. This paper demonstrates the complexity and challenges of mapping across terminological systems in the context of medication information. It provides a review of medication terminological systems and their linkages, then describes a case study in which we mapped proprietary medication codes from an electronic health record to SNOMED-CT and the UMLS Metathesaurus. The goal was to create a polyhierarchical classification system for querying an i2b2 clinical data warehouse. We found that three methods were required to accurately map the majority of actively prescribed medications. Only 62.5% of source medication codes could be mapped automatically. The remaining codes were mapped using a combination of semi-automated string comparison with expert selection, and a completely manual approach. Compound drugs were especially difficult to map: only 7.5% could be mapped using the automatic method. General challenges to mapping across terminological systems include (1) the availability of up-to-date information to assess the suitability of a given terminological system for a particular use case, and to assess the quality and completeness of cross-terminology links; (2) the difficulty of correctly using complex, rapidly evolving, modern terminologies; (3) the time and effort required to complete and evaluate the mapping; (4) the need to address differences in granularity between the source and target terminologies; and (5) the need to continuously update the mapping as terminological systems evolve. PMID:22750536

  4. Pediatric Intubation by Paramedics in a Large Emergency Medical Services System: Process, Challenges, and Outcomes.

    Science.gov (United States)

    Prekker, Matthew E; Delgado, Fernanda; Shin, Jenny; Kwok, Heemun; Johnson, Nicholas J; Carlbom, David; Grabinsky, Andreas; Brogan, Thomas V; King, Mary A; Rea, Thomas D

    2016-01-01

    Pediatric intubation is a core paramedic skill in some emergency medical services (EMS) systems. The literature lacks a detailed examination of the challenges and subsequent adjustments made by paramedics when intubating children in the out-of-hospital setting. We undertake a descriptive evaluation of the process of out-of-hospital pediatric intubation, focusing on challenges, adjustments, and outcomes. We performed a retrospective analysis of EMS responses between 2006 and 2012 that involved attempted intubation of children younger than 13 years by paramedics in a large, metropolitan EMS system. We calculated the incidence rate of attempted pediatric intubation with EMS and county census data. To summarize the intubation process, we linked a detailed out-of-hospital airway registry with clinical records from EMS, hospital, or autopsy encounters for each child. The main outcome measures were procedural challenges, procedural success, complications, and patient disposition. Paramedics attempted intubation in 299 cases during 6.3 years, with an incidence of 1 pediatric intubation per 2,198 EMS responses. Less than half of intubations (44%) were for patients in cardiac arrest. Two thirds of patients were intubated on the first attempt (66%), and overall success was 97%. The most prevalent challenge was body fluids obscuring the laryngeal view (33%). After a failed first intubation attempt, corrective actions taken by paramedics included changing equipment (33%), suctioning (32%), and repositioning the patient (27%). Six patients (2%) experienced peri-intubation cardiac arrest and 1 patient had an iatrogenic tracheal injury. No esophageal intubations were observed. Of patients transported to the hospital, 86% were admitted to intensive care and hospital mortality was 27%. Pediatric intubation by paramedics was performed infrequently in this EMS system. Although overall intubation success was high, a detailed evaluation of the process of intubation revealed specific

  5. Building Applications, Opportunities and Challenges of Active Shading Systems: A State-of-the-Art Review

    Directory of Open Access Journals (Sweden)

    Joud Al Dakheel

    2017-10-01

    Full Text Available Active shading systems in buildings have emerged as a high performing shading solution that selectively and optimally controls daylight and heat gains. Active shading systems are increasingly used in buildings, due to their ability to mainly improve the building environment, reduce energy consumption and in some cases generate energy. They may be categorized into three classes: smart glazing, kinetic shading and integrated renewable energy shading. This paper reviews the current status of the different types in terms of design principle and working mechanism of the systems, performance, control strategies and building applications. Challenges, limitations and future opportunities of the systems are then discussed. The review highlights that despite its high initial cost, the electrochromic (EC glazing is the most applied smart glazing due to the extensive use of glass in buildings under all climatic conditions. In terms of external shadings, the rotating shading type is the predominantly used one in buildings due to its low initial cost. Algae façades and folding shading systems are still emerging types, with high initial and maintenance costs and requiring specialist installers. The algae façade systems and PV integrated shading systems are a promising solution due to their dual benefits of providing shading and generating electricity. Active shading systems were found to save 12 to 50% of the building cooling electricity consumption.

  6. [Primary malignant melanoma of the central nervous system: A diagnostic challenge].

    Science.gov (United States)

    Quillo-Olvera, Javier; Uribe-Olalde, Juan Salvador; Alcántara-Gómez, Leopoldo Alberto; Rejón-Pérez, Jorge Dax; Palomera-Gómez, Héctor Guillermo

    2015-01-01

    The rare incidence of primary malignant melanoma of the central nervous system and its ability to mimic other melanocytic tumors on images makes it a diagnostic challenge for the neurosurgeon. A 51-year-old patient, with a tumor located in the right forniceal callosum area. Total surgical excision was performed. Histopathological result was consistent with the diagnosis of primary malignant melanoma of the central nervous system, after ruling out extra cranial and extra spinal melanocytic lesions. The primary malignant melanoma of the central nervous system is extremely rare. There are features in magnetic resonance imaging that increase the diagnostic suspicion; nevertheless there are other tumors with more prevalence that share some of these features through image. Since there is not an established therapeutic standard its prognosis is discouraging. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  7. U.S. Experiences in Tackling Energy and Environmental Challenges of Boiler System

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lu, Hongyou [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Price, Lynn K. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-08-15

    In the U.S., energy consumption by steam and process heat combined accounts for over 50% of the total energy use from industrial systems (see Figure 1). The use of boilers, process heaters, and furnaces for generating steam and heat in industrial facilities, commercial settings, and institutions consumes significant amounts of energy and is one of major sources of hazardous air pollutants, which contribute significantly to local pollution and global climate change. To address the energy and environmental challenges caused by boiler systems in the U.S., the country has taken a series of actions to reduce emissions from industrial, commercial and institutional boilers, improve the efficiency of steam systems, replace coal with cleaner energy resources, and promote the wider use of combined heat and power (CHP).

  8. Cloud Based Educational Systems 
And Its Challenges And Opportunities And Issues

    Directory of Open Access Journals (Sweden)

    Prantosh Kr. PAUL

    2014-01-01

    Full Text Available Cloud Computing (CC is actually is a set of hardware, software, networks, storage, services an interface combines to deliver aspects of computing as a service. Cloud Computing (CC actually uses the central remote servers to maintain data and applications. Practically Cloud Computing (CC is extension of Grid computing with independency and smarter tools and technological gradients. Healthy Cloud Computing helps in sharing of software, hardware, application and other packages with the help of internet tools and wireless media. Cloud Computing, has benefits in several field and applications domain such as Agriculture, Business and Commerce, Health Care, Hospitality and Tourism, Education and Training sector and so on. In Education Systems, it may be applicable in general regular education and other education systems including general and vocational training. This paper is talks about opportunities that provide Cloud Computing (CC; however the intention would be challenges and issues in relation to Education, Education Systems and Training programme.

  9. Turning challenges into design principles: Telemonitoring systems for patients with multiple chronic conditions.

    Science.gov (United States)

    Sultan, Mehwish; Kuluski, Kerry; McIsaac, Warren J; Cafazzo, Joseph A; Seto, Emily

    2018-01-01

    People with multiple chronic conditions often struggle with managing their health. The purpose of this research was to identify specific challenges of patients with multiple chronic conditions and to use the findings to form design principles for a telemonitoring system tailored for these patients. Semi-structured interviews with 15 patients with multiple chronic conditions and 10 clinicians were conducted to gain an understanding of their needs and preferences for a smartphone-based telemonitoring system. The interviews were analyzed using a conventional content analysis technique, resulting in six themes. Design principles developed from the themes included that the system must be modular to accommodate various combinations of conditions, reinforce a routine, consolidate record keeping, as well as provide actionable feedback to the patients. Designing an application for multiple chronic conditions is complex due to variability in patient conditions, and therefore, design principles developed in this study can help with future innovations aimed to help manage this population.

  10. Mechatronic futures challenges and solutions for mechatronic systems and their designers

    CERN Document Server

    Bradley, David

    2016-01-01

    Offering a comprehensive overview of the challenges, risks and options facing the future of mechatronics, this book provides insights into how these issues are currently assessed and managed. Building on the previously published book ‘Mechatronics in Action,’ it identifies and discusses the key issues likely to impact on future mechatronic systems. It supports mechatronics practitioners in identifying key areas in design, modeling and technology and places these in the wider context of concepts such as cyber-physical systems and the Internet of Things. For educators it considers the potential effects of developments in these areas on mechatronic course design, and ways of integrating these. Written by experts in the field, it explores topics including systems integration, design, modeling, privacy, ethics and future application domains. Highlighting novel innovation directions, it is intended for academics, engineers and students working in the field of mechatronics, particularly those developing new conc...

  11. Public health systems under attack in Canada: Evidence on public health system performance challenges arbitrary reform.

    Science.gov (United States)

    Guyon, Ak'ingabe; Perreault, Robert

    2016-10-20

    Public health is currently being weakened in several Canadian jurisdictions. Unprecedented and arbitrary cuts to the public health budget in Quebec in 2015 were a striking example of this. In order to support public health leaders and citizens in their capacity to advocate for evidence-informed public health reforms, we propose a knowledge synthesis of elements of public health systems that are significantly associated with improved performance. Research consistently and significantly associates four elements of public health systems with improved productivity: 1) increased financial resources, 2) increased staffing per capita, 3) population size between 50,000 and 500,000, and 4) specific evidence-based organizational and administrative features. Furthermore, increased financial resources and increased staffing per capita are significantly associated with improved population health outcomes. We contend that any effort at optimization of public health systems should at least be guided by these four evidence-informed factors. Canada already has existing capacity in carrying out public health systems and services research. Further advancement of our academic and professional expertise on public health systems will allow Canadian public health jurisdictions to be inspired by the best public health models and become stronger advocates for public health's resources, interventions and outcomes when they need to be celebrated or defended.

  12. A remote in-vessel and ex-vessel force-reflecting telerobotic system for the burning plasma experiment

    International Nuclear Information System (INIS)

    Kuban, D.P.; Busko, N.

    1992-01-01

    The Burning Plasma Experiment (BPX) has made an applaudable commitment to total remote maintenance which will undoubtedly move fusion energy closer to commercial reality. This commitment poses new and formidable challenges due to the dimensional constraints, diversity of maintenance operations, and the geometrically intricate equipment arrangements. These challenges must be addressed for successful hot operation of the Princeton Plasma Physics Laboratory BPX. This paper reports on a new manipulator system, called the TeleMate, which is under development to contribute to this needed capability. This system combines enhancements to a proven mechanical design with state-of-the-art controls technology, to produce a flexible system that can be configured to address the numerous remote fusion applications. The mechanical portion of the system has many years of operation in existing radioactive facilities. This paper presents a system description, the development status, initial test data, and control system performance

  13. The challenges of integrating multiple safeguards systems in a large nuclear facility

    International Nuclear Information System (INIS)

    Lavietes, A.; Liguori, C.; Pickrell, M.; Plenteda, R.; Sweet, M.

    2009-01-01

    Full-text: Implementing safeguards in a cost-effective manner in large nuclear facilities such as fuel conditioning, fuel reprocessing, and fuel fabrication plants requires the extensive use of instrumentation that is operated in unattended mode. The collected data is then periodically reviewed by the inspectors either on-site at a central location in the facility or remotely in the IAEA offices. A wide variety of instruments are deployed in large facilities, including video surveillance cameras, electronic sealing devices, non-destructive assay systems based on gamma ray and neutron detection, load cells for mass measurement, ID-readers, and other process-specific monitors. The challenge to integrate these different measurement instruments into an efficient, reliable, and secure system requires implementing standardization at various levels throughout the design process. This standardization includes the data generator behaviour and interface, networking solutions, and data security approaches. This standardization will provide a wide range of savings, including reduced training for inspectors and technicians, reduced periodic technical maintenance, reduced spare parts inventory, increased system robustness, and more predictive system behaviour. The development of standard building blocks will reduce the number of data generators required and allow implementation of simplified architectures that do not require local collection computers but rather utilize transmission of the acquired data directly to a central server via Ethernet connectivity. This approach will result in fewer system components and therefore reduced maintenance efforts and improved reliability. This paper discusses in detail the challenges and the subsequent solutions in the various areas that the IAEA Department of Safeguards has committed to pursue as the best sustainable way of maintaining the ability to implement reliable safeguards systems. (author)

  14. Challenges in network science: Applications to infrastructures, climate, social systems and economics

    Science.gov (United States)

    Havlin, S.; Kenett, D. Y.; Ben-Jacob, E.; Bunde, A.; Cohen, R.; Hermann, H.; Kantelhardt, J. W.; Kertész, J.; Kirkpatrick, S.; Kurths, J.; Portugali, J.; Solomon, S.

    2012-11-01

    Network theory has become one of the most visible theoretical frameworks that can be applied to the description, analysis, understanding, design and repair of multi-level complex systems. Complex networks occur everywhere, in man-made and human social systems, in organic and inorganic matter, from nano to macro scales, and in natural and anthropogenic structures. New applications are developed at an ever-increasing rate and the promise for future growth is high, since increasingly we interact with one another within these vital and complex environments. Despite all the great successes of this field, crucial aspects of multi-level complex systems have been largely ignored. Important challenges of network science are to take into account many of these missing realistic features such as strong coupling between networks (networks are not isolated), the dynamics of networks (networks are not static), interrelationships between structure, dynamics and function of networks, interdependencies in given networks (and other classes of links, including different signs of interactions), and spatial properties (including geographical aspects) of networks. This aim of this paper is to introduce and discuss the challenges that future network science needs to address, and how different disciplines will be accordingly affected.

  15. Materials and structures technology insertion into spacecraft systems: Successes and challenges

    Science.gov (United States)

    Rawal, Suraj

    2018-05-01

    Over the last 30 years, significant advancements have led to the use of multifunctional materials and structures technologies in spacecraft systems. This includes the integration of adaptive structures, advanced composites, nanotechnology, and additive manufacturing technologies. Development of multifunctional structures has been directly influenced by the implementation of processes and tools for adaptive structures pioneered by Prof. Paolo Santini. Multifunctional materials and structures incorporating non-structural engineering functions such as thermal, electrical, radiation shielding, power, and sensors have been investigated. The result has been an integrated structure that offers reduced mass, packaging volume, and ease of integration for spacecraft systems. Current technology development efforts are being conducted to develop innovative multifunctional materials and structures designs incorporating advanced composites, nanotechnology, and additive manufacturing. However, these efforts offer significant challenges in the qualification and acceptance into spacecraft systems. This paper presents a brief overview of the technology development and successful insertion of advanced material technologies into spacecraft structures. Finally, opportunities and challenges to develop and mature next generation advanced materials and structures are presented.

  16. Overcoming the Challenges of Implementing a Multi-Mission Distributed Workflow System

    Science.gov (United States)

    Sayfi, Elias; Cheng, Cecilia; Lee, Hyun; Patel, Rajesh; Takagi, Atsuya; Yu, Dan

    2009-01-01

    A multi-mission approach to solving the same problems for various projects is enticing. However, the multi-mission approach leads to the need to develop a configurable, adaptable and distributed system to meet unique project requirements. That, in turn, leads to a set of challenges varying from handling synchronization issues to coming up with a smart design that allows the "unknowns" to be decided later. This paper discusses the challenges that the Multi-mission Automated Task Invocation Subsystem (MATIS) team has come up against while designing the distributed workflow system, as well as elaborates on the solutions that were implemented. The first is to design an easily adaptable system that requires no code changes as a result of configuration changes. The number of formal deliveries is often limited because each delivery costs time and money. Changes such as the sequence of programs being called, a change of a parameter value in the program that is being automated should not result in code changes or redelivery.

  17. Data Mining for Wearable Sensors in Health Monitoring Systems: A Review of Recent Trends and Challenges

    Directory of Open Access Journals (Sweden)

    Hadi Banaee

    2013-12-01

    Full Text Available The past few years have witnessed an increase in the development of wearable sensors for health monitoring systems. This increase has been due to several factors such as development in sensor technology as well as directed efforts on political and stakeholder levels to promote projects which address the need for providing new methods for care given increasing challenges with an aging population. An important aspect of study in such system is how the data is treated and processed. This paper provides a recent review of the latest methods and algorithms used to analyze data from wearable sensors used for physiological monitoring of vital signs in healthcare services. In particular, the paper outlines the more common data mining tasks that have been applied such as anomaly detection, prediction and decision making when considering in particular continuous time series measurements. Moreover, the paper further details the suitability of particular data mining and machine learning methods used to process the physiological data and provides an overview of the properties of the data sets used in experimental validation. Finally, based on this literature review, a number of key challenges have been outlined for data mining methods in health monitoring systems.

  18. A Primitive Memory System for Attention Deployments: Some Recent Challenges and Their Resolution

    Directory of Open Access Journals (Sweden)

    Árni Kristjánsson

    2011-05-01

    Full Text Available In the past my colleagues and I have presented evidence for the existence of a primitive memory for attention deployments. This memory system orients attention to features and locations of recent behavioral importance. A large part of the proposal is that the memory system facilitates attentional selection of features in the environment such as color, orientation, etc. I will review the findings behind these proposals. The bulk of this evidence comes from studies of history effects in vision, such as priming of visual search, and implicit learning in exogenously cued attention shifts. In addition, recent challenges to this view will be discussed (in particular, arguments that the facilitation from repetition in visual search tasks occurs at a relatively late stage of perceptual processing. Our recent investigations of these proposals suggest that there is indeed evidence for higher-level priming effects in visual search under certain conditions, but those findings do not challenge the basic proposals regarding the primitive memory system, since the evidence for feature-specific facilitation is robust.

  19. New capabilities in the HENP grand challenge storage access system and its application at RHIC

    International Nuclear Information System (INIS)

    Bernardo, L.; Gibbard, B.; Malon, D.; Nordberg, H.; Olson, D.; Porter, R.; Shoshani, A.; Sim, A.; Vaniachine, A.; Wenaus, T.; Wu, K.; Zimmerman, D.

    2000-01-01

    The High Energy and Nuclear Physics Data Access Grand Challenge project has developed an optimizing storage access software system that was prototyped at RHIC. It is currently undergoing integration with the STAR experiment in preparation for data taking that starts in mid-2000. The behavior and lessons learned in the RHIC Mock Data Challenge exercises are described as well as the observed performance under conditions designed to characterize scalability. Up to 250 simultaneous queries were tested and up to 10 million events across 7 event components were involved in these queries. The system coordinates the staging of ''bundles'' of files from the HPSS tape system, so that all the needed components of each event are in disk cache when accessed by the application software. The caching policy algorithm for the coordinated bundle staging is described in the paper. The initial prototype implementation interfaced to the Objectivity/DB. In this latest version, it evolved to work with arbitrary files and use CORBA interfaces to the tag database and file catalog services. The interface to the tag database and the MySQL-based file catalog services used by STAR are described along with the planned usage scenarios

  20. Phenotype prediction using regularized regression on genetic data in the DREAM5 Systems Genetics B Challenge.

    Directory of Open Access Journals (Sweden)

    Po-Ru Loh

    Full Text Available A major goal of large-scale genomics projects is to enable the use of data from high-throughput experimental methods to predict complex phenotypes such as disease susceptibility. The DREAM5 Systems Genetics B Challenge solicited algorithms to predict soybean plant resistance to the pathogen Phytophthora sojae from training sets including phenotype, genotype, and gene expression data. The challenge test set was divided into three subcategories, one requiring prediction based on only genotype data, another on only gene expression data, and the third on both genotype and gene expression data. Here we present our approach, primarily using regularized regression, which received the best-performer award for subchallenge B2 (gene expression only. We found that despite the availability of 941 genotype markers and 28,395 gene expression features, optimal models determined by cross-validation experiments typically used fewer than ten predictors, underscoring the importance of strong regularization in noisy datasets with far more features than samples. We also present substantial analysis of the training and test setup of the challenge, identifying high variance in performance on the gold standard test sets.

  1. The challenge of establishing treatment efficacy for cutaneous vascular manifestations of systemic sclerosis.

    Science.gov (United States)

    Pauling, John D

    2018-05-01

    The cutaneous vascular manifestations of systemic sclerosis (SSc) comprise Raynaud's phenomenon, cutaneous ulceration, telangiectasia formation and critical digital ischaemia; each of which are associated with significant disease-related morbidity. Despite the availability of multiple classes of vasodilator therapy, many of which have been the subject of RCTs, a limited number of pharmacological interventions are currently approved for the management of cutaneous vascular manifestations of SSc. Areas covered: A major challenge has been demonstrating treatment efficacy with examples of promising therapies yielding contrasting results in controlled trial settings. Differences between consensus best-practice guidelines, evidence-based recommendations and marketing approvals in different jurisdictions has resulted in geographic variation in clinical practice concerning the management of cutaneous vascular manifestations of SSc. Difficulty demonstrating treatment efficacy risks waning industry engagement for drug development programmes in this field. This article highlights the key challenges in establishing treatment efficacy and barriers that must be overcome to support successful clinical trial programmes across the spectrum of cutaneous vascular manifestations of SSc. Expert commentary: The paucity of approved treatments for cutaneous vascular manifestations of SSc relates as much to challenges in clinical trial design and the need for reliable clinical trial endpoints, as to lack of therapeutic options.

  2. The GLOFOULING Partnerships project and the anti-fouling systems: challenges for Marine Environment Protection

    Directory of Open Access Journals (Sweden)

    Fabián Ramírez Cabrales

    2018-05-01

    Full Text Available Within the framework of the Agenda 2030 for Sustainable Development, the regulation of international maritime transport is a priority to face the challenges on the Protection of the Marine Environment. However, some states present difficulties in complying with international or normative agreements adopted by the International Maritime Organization (IMO. In particular, we revised the Guidelines for the control and management of ships’ biofouling to minimize the transfer of invasive aquatic species and their linkage with the Glofouling Associations project, including the adverse effects of the use of antifouling systems and the biocides that may contain. As preliminary results, we identified the challenges that this global project entails for States, shipbuilders, ship maintenance and cleaning companies, universities, port authorities, repair facilities, dry docks and ship recycling, manufacturers and suppliers of anti-fouling paints and other stakeholders. We concluded that the challenges for the international maritime community are linked to the ability of States and stakeholders to enhance scientific knowledge, develop research capacity and transfer marine technology to mitigate marine biological contamination of ships.

  3. Development of sustainable energy systems: a new challenge for process systems engineering education

    OpenAIRE

    Astier, Stéphan; Ayache, Antoine; Azzaro-Pantel, Catherine; David, Maria; Fontes, Guillaume; Gourdon, Christophe; Joulia, Xavier; Le Lann, Jean-Marc

    2008-01-01

    This paper presents the main features of the master-level programme in “EcoEnergy” offered as a full-time one year course at “Institut National Polytechnique of Toulouse” in order to provide engineers with a state-of-the-art education in the area of advanced energy technologies and systems. It is based on an original and equilibrated combination of process systems engineering and electrical engineering disciplines, with an interdisciplinary problem-solving approach necessary for identifying s...

  4. Challenges in legislation, recycling system and technical system of waste electrical and electronic equipment in China.

    Science.gov (United States)

    Zhang, Shengen; Ding, Yunji; Liu, Bo; Pan, De'an; Chang, Chein-chi; Volinsky, Alex A

    2015-11-01

    Waste electrical and electronic equipment (WEEE) has been one of the fastest growing waste streams worldwide. Effective and efficient management and treatment of WEEE has become a global problem. As one of the world's largest electronic products manufacturing and consumption countries, China plays a key role in the material life cycle of electrical and electronic equipment. Over the past 20 years, China has made a great effort to improve WEEE recycling. Centered on the legal, recycling and technical systems, this paper reviews the progresses of WEEE recycling in China. An integrated recycling system is proposed to realize WEEE high recycling rate for future WEEE recycling. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Communication for Change in the Challenge of Systemic Crisis. Latin American Perspective

    Directory of Open Access Journals (Sweden)

    Alejandro Barranquero

    2013-05-01

    Full Text Available The examination of the relationship between communication and development in a context of climate change and global systemic crisis challenges us to come to terms with the importance of the limits of human intervention on nature and against the logic of unlimited growth determined by modern and capitalist rationality. In this context, Latin America has usually played an influential and pioneering role in the questioning of development imaginaries from the dependency and participatory theories in the 60s and 70s and nowadays through the biocentric turn proposed by Living Well and other critical ecology perspectives.

  6. The regulatory control of radiation sources in Australia -- The challenges of a federal system

    International Nuclear Information System (INIS)

    Loy, J.; Colgan, P.

    2001-01-01

    The report refers to the challenges that Australia is facing, as a federal nation having a Commonwealth Government and six States and two territories, in establishing appropriate regulatory control of radiation sources. Information on the national inventory of radiation sources and existing regulatory infrastructure, including the system of notification, registration, licensing, inspection and enforcement, is explained in the report. The national provisions for the management of disused sources; the planning, preparedness and response to abnormal events and emergencies; the recovery of control over orphan sources; and education and training; are specifically emphasized. (author)

  7. Challenges and Specifications for Robust Face and Gait Recognition Systems for Surveillance Application

    Directory of Open Access Journals (Sweden)

    BUCIU Ioan

    2014-05-01

    Full Text Available Automated person recognition (APR based on biometric signals addresses the process of automatically recognize a person according to his physiological traits (face, voice, iris, fingerprint, ear shape, body odor, electroencephalogram – EEG, electrocardiogram, or hand geometry, or behavioural patterns (gait, signature, hand-grip, lip movement. The paper aims at briefly presenting the current challenges for two specific non-cooperative biometric approaches, namely face and gait biometrics as well as approaches that consider combination of the two in the attempt of a more robust system for accurate APR, in the context of surveillance application. Open problems from both sides are also pointed out.

  8. Health system challenges in organizing quality diabetes care for urban poor in South India.

    Science.gov (United States)

    Bhojani, Upendra; Devedasan, Narayanan; Mishra, Arima; De Henauw, Stefaan; Kolsteren, Patrick; Criel, Bart

    2014-01-01

    Weak health systems in low- and middle-income countries are recognized as the major constraint in responding to the rising burden of chronic conditions. Despite recognition by global actors for the need for research on health systems, little attention has been given to the role played by local health systems. We aim to analyze a mixed local health system to identify the main challenges in delivering quality care for diabetes mellitus type 2. We used the health system dynamics framework to analyze a health system in KG Halli, a poor urban neighborhood in South India. We conducted semi-structured interviews with healthcare providers located in and around the neighborhood who provide care to diabetes patients: three specialist and 13 non-specialist doctors, two pharmacists, and one laboratory technician. Observations at the health facilities were recorded in a field diary. Data were analyzed through thematic analysis. There is a lack of functional referral systems and a considerable overlap in provision of outpatient care for diabetes across the different levels of healthcare services in KG Halli. Inadequate use of patients' medical records and lack of standard treatment protocols affect clinical decision-making. The poor regulation of the private sector, poor systemic coordination across healthcare providers and healthcare delivery platforms, widespread practice of bribery and absence of formal grievance redress platforms affect effective leadership and governance. There appears to be a trust deficit among patients and healthcare providers. The private sector, with a majority of healthcare providers lacking adequate training, operates to maximize profit, and healthcare for the poor is at best seen as charity. Systemic impediments in local health systems hinder the delivery of quality diabetes care to the urban poor. There is an urgent need to address these weaknesses in order to improve care for diabetes and other chronic conditions.

  9. Health system challenges in organizing quality diabetes care for urban poor in South India.

    Directory of Open Access Journals (Sweden)

    Upendra Bhojani

    Full Text Available BACKGROUND: Weak health systems in low- and middle-income countries are recognized as the major constraint in responding to the rising burden of chronic conditions. Despite recognition by global actors for the need for research on health systems, little attention has been given to the role played by local health systems. We aim to analyze a mixed local health system to identify the main challenges in delivering quality care for diabetes mellitus type 2. METHODS: We used the health system dynamics framework to analyze a health system in KG Halli, a poor urban neighborhood in South India. We conducted semi-structured interviews with healthcare providers located in and around the neighborhood who provide care to diabetes patients: three specialist and 13 non-specialist doctors, two pharmacists, and one laboratory technician. Observations at the health facilities were recorded in a field diary. Data were analyzed through thematic analysis. RESULT: There is a lack of functional referral systems and a considerable overlap in provision of outpatient care for diabetes across the different levels of healthcare services in KG Halli. Inadequate use of patients' medical records and lack of standard treatment protocols affect clinical decision-making. The poor regulation of the private sector, poor systemic coordination across healthcare providers and healthcare delivery platforms, widespread practice of bribery and absence of formal grievance redress platforms affect effective leadership and governance. There appears to be a trust deficit among patients and healthcare providers. The private sector, with a majority of healthcare providers lacking adequate training, operates to maximize profit, and healthcare for the poor is at best seen as charity. CONCLUSIONS: Systemic impediments in local health systems hinder the delivery of quality diabetes care to the urban poor. There is an urgent need to address these weaknesses in order to improve care for diabetes

  10. Dealing with Health and Health Care System Challenges in China: assessing health determinants and health care reforms

    NARCIS (Netherlands)

    H. Zhang (Hao)

    2017-01-01

    markdownabstractThis dissertation investigates the challenges faced by China around 2010 in two domains – population health and the health care system. Specifically, chapters 2 and 3 are devoted to health challenges, explaining the female health disadvantage in later life and assessing the effect

  11. Enrolling Advisers in Governing Privatised Agricultural Extension in Australia: Challenges and Opportunities for the Research, Development and Extension System

    Science.gov (United States)

    Paschen, Jana-Axinja; Reichelt, Nicole; King, Barbara; Ayre, Margaret; Nettle, Ruth

    2017-01-01

    Purpose: Current developments in the Australian agricultural research, development and extension (RD&E) system exemplify the complex governance challenges arising from the international privatisation of agricultural extension. Presenting early challenges emerging from a multi-stakeholder project aimed at stimulating the role of the private…

  12. Groundwater and human development: challenges and opportunities in livelihoods and environment.

    Science.gov (United States)

    Shah, T

    2005-01-01

    At less than 1000 km3/year, the world's annual use of groundwater is 1.5% of renewable water resource but contributes a lion's share of water-induced human welfare. Global groundwater use however has increased manifold in the past 50 years; and the human race has never had to manage groundwater use on such a large scale. Sustaining the massive welfare gains groundwater development has created without ruining the resource is a key water challenge facing the world today. In exploring this challenge, we have focused a good deal on conditions of resource occurrence but less so on resource use. I offer a typology of five groundwater demand systems as Groundwater Socio-ecologies (GwSE), each embodying a unique pattern of interactions between socio-economic and ecological variables, and each facing a distinct groundwater governance challenge. During the past century, a growing corpus of experiential knowledge has accumulated in the industrialized world on managing groundwater in various uses and contexts. A daunting global groundwater issue today is to apply this knowledge intelligently to by far the more formidable challenge that has arisen in developing regions of Asia and Africa, where groundwater irrigation has evolved into a colossal anarchy supporting billions of livelihoods but threatening the resource itself.

  13. Challenges to modeling the Sun-Earth System: A Workshop Summary

    Science.gov (United States)

    Spann, James F.

    2006-01-01

    This special issue of the Journal of' Atmospheric and Solar-Terrestrial Physics is a compilation of 23 papers presented at The 2004 Huntsville Modeling Workshop: Challenges to Modeling thc San-Earth System held in Huntsville, AB on October 18-22, 2004. The title of the workshop appropriately captures the theme of what was presented and discussed by the 120 participants. Currently, end-to-end modeling of the Sun-Earth system is a major goal of the National Space Weather and NASA living with a star (LWS) programs. While profound advances have been made in modeling isolated regions of the Sun-Earth system, minimal progress has been achieved in modeling the end-to-end system. The transfer of mass, energy and momentum through the coupled Sun-Earth system spans a wide range of scales inn time and space. The uncertainty in the underlying physics responsible for coupling contiguous regions of the Sun-Earth system is recognized as a significant barrier to progress

  14. Challenges in the implementation of a quality management system applied to radiometric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Danila C.S.; Bonifacio, Rodrigo L.; Nascimento, Marcos R.L.; Silva, Nivaldo C. da; Taddei, Maria Helena T., E-mail: danilacdias@gmail.com [Comissao Nacional de Energia Nuclear (LAPOC/CNEN-MG), Pocos de Caldas, MG (Brazil). Laboratorio de Pocos de Caldas

    2015-07-01

    The concept of quality in laboratories has been well established as an essential factor in the search for reliable results. Since its first version published (1999), the ISO/IEC 17025 has been applied in the industrial and research fields, in a wide range of laboratorial analyses. However, the implementation of a Quality Management System still poses great challenges to institutions and companies. The purpose of this work is to expose the constraints related to the implementation of ISO/IEC 17025 applied to analytical assays of radionuclides, accomplished by studying the case of the Pocos de Caldas Laboratory of the Brazilian Commission for Nuclear Energy. In this lab, a project of accreditation of techniques involving determination of radionuclides in water, soil, sediment and food samples has been conducted since 2011. The challenges presented by this project arise from the administrative view, where the governmental nature of the institution translates into unlevelled availability resources and the organizational view, whereas QMS requires inevitable changes in the organizational culture. It is important to point out that when it comes to accreditation of analysis involving radioactive elements, many aspects must be treated carefully due to the their very particular nature. Among these concerns are the determination of analysis uncertainties, accessibility to international proficiency studies, international radioactive samples and CRM transportation, the study of parameters on the validation of analytical methods and the lack of documentation and specialized personnel regarding quality at radiometric measurements. Through an effective management system, the institution is overcoming these challenges, moving toward the ISO/IEC 17025 accreditation. (author)

  15. Challenges in the implementation of a quality management system applied to radiometric analysis

    International Nuclear Information System (INIS)

    Dias, Danila C.S.; Bonifacio, Rodrigo L.; Nascimento, Marcos R.L.; Silva, Nivaldo C. da; Taddei, Maria Helena T.

    2015-01-01

    The concept of quality in laboratories has been well established as an essential factor in the search for reliable results. Since its first version published (1999), the ISO/IEC 17025 has been applied in the industrial and research fields, in a wide range of laboratorial analyses. However, the implementation of a Quality Management System still poses great challenges to institutions and companies. The purpose of this work is to expose the constraints related to the implementation of ISO/IEC 17025 applied to analytical assays of radionuclides, accomplished by studying the case of the Pocos de Caldas Laboratory of the Brazilian Commission for Nuclear Energy. In this lab, a project of accreditation of techniques involving determination of radionuclides in water, soil, sediment and food samples has been conducted since 2011. The challenges presented by this project arise from the administrative view, where the governmental nature of the institution translates into unlevelled availability resources and the organizational view, whereas QMS requires inevitable changes in the organizational culture. It is important to point out that when it comes to accreditation of analysis involving radioactive elements, many aspects must be treated carefully due to the their very particular nature. Among these concerns are the determination of analysis uncertainties, accessibility to international proficiency studies, international radioactive samples and CRM transportation, the study of parameters on the validation of analytical methods and the lack of documentation and specialized personnel regarding quality at radiometric measurements. Through an effective management system, the institution is overcoming these challenges, moving toward the ISO/IEC 17025 accreditation. (author)

  16. Introducing the emissions trading system to China’s electricity sector: Challenges and opportunities

    International Nuclear Information System (INIS)

    Teng, Fei; Wang, Xin; Zhiqiang, LV

    2014-01-01

    We examine the challenges and opportunities to introduce emissions trading (ETS) in China’s electricity sector, in which the interaction between ETS and electricity market reform plays a major role. China’s electricity sector is currently in a slow progress towards a more competitive and market-based system. Both equal share dispatching policy and regulated wholesale and retail pricing policies pose significant challenges for implementation of ETS in China’s electricity sector. One of the important points of ETS is to give a price for carbon emissions and establish a cost pass-through mechanism (reminded that the essential of carbon pricing is to put a price on carbon emissions that is equal to discounted value of the external damages). It should be regarded as a part of broader policy package for energy and resources price reform. This will require that any low-carbon power policy should be considered as a part of whole policy package aiming at further liberalizing the electricity sector in China. Three policy options are identified to incorporate ETS with electricity reform under different circumstances. A combination of those three options is also proposed to break the lock and reinforce the positive interaction between ETS and the transition towards a competitive electricity system, in link with current pilot ETS designs. A roadmap to introduce ETS in a stepwise manner is suggested. - Highlights: • We assess the institutional barriers of electricity market to ETS in China. • Major challenges to ETS come from equal share dispatching an regulated pricing policies. • Several options are examined to reconcile the ETS and electricity market in China

  17. The integration of renewable energy in the French electricity system: what challenges for optimization?

    International Nuclear Information System (INIS)

    Mathieu, Mathilde; Ruedinger, Andreas; Pescia, Dimitri

    2016-01-01

    Based on research reports and dialogue through expert seminars organized by IDDRI and Agora Energiewende in 2015, this Working Paper proposes a synthesis of the main challenges for the integration of renewable energies using an analysis of the electricity system and its potential for optimization over different time frames: the potential evolution of electricity systems at the regional and national levels in France between now and 2030; an analysis of the needs and options for flexibility services beyond production systems; the potential for optimization of instruments to encourage short-term integration in line with changes in regulation regarding RES support schemes. Achieving the targets for renewable energy development (RES-E) in France (40% share of the electricity consumption) and in Europe (approximately 50%) by 2030 poses new integration challenges. The successful transformation of the electricity system based on a significant renewable component requires a systemic approach which takes into account: the evolution of demand and supply (for electricity and all energy), the interactions and competition between flexibility options for system stabilization (interconnections, active demand-side management, storage), the development of relevant infrastructure and articulation between the technical system and market design. A forward-looking analysis of electricity systems helps to assess this increase in flexibility requirements while identifying several optimization options to facilitate RES integration, starting with regional coordination. France already has a flexible electricity system, thanks notably to its hydro potential. Even so, its evolution towards 40% RES by 2030 calls for some strategic choices. On the one hand, drawing up a long-term trajectory for the evolution of electricity demand - in terms of volume as well as the nature of needs addressed - seems essential to bring coherence to the evolution of the technology portfolio and to increase the

  18. Cancer vaccines: the challenge of developing an ideal tumor killing system.

    Science.gov (United States)

    Mocellin, Simone

    2005-09-01

    Despite the evidence that the immune system plays a significant role in controlling tumor growth in natural conditions and in response to therapeutic vaccination, cancer cells can survive their attack as the disease progresses and no vaccination regimen should be currently proposed to patients outside experimental clinical trials. Clinical results show that the immune system can be actively polarized against malignant cells by means of a variety of vaccination strategies, and that in some cases this is associated with tumor regression. This implies that under some unique circumstances, the naturally "dormant" immune effectors can actually be put at work and used as endogenous weapons against malignant cells. Consequently, the main challenge of tumor immunologists appears to lie on the ability of reproducing those conditions in a larger set of patients. The complexity of the immune network and the still enigmatic host-tumor interactions make these tasks at the same time challenging and fascinating. Recent tumor immunology findings are giving new impetus to the development of more effective vaccination strategies and might revolutionize the way of designing the next generation of cancer vaccines. In the near future, the implementation of these insights in the clinical setting and the completion/conduction of comparative randomized phase III trials will allow oncologists to define the actual role of cancer vaccines in the fight against malignancy.

  19. Obstacles and Challenges to Gender Parity. Political Violence, Electoral System and Interculturalism

    Directory of Open Access Journals (Sweden)

    Laura Albaine

    2015-05-01

    Full Text Available This study is a contribution to the debate about the adoption of gender parity policies in Latin America analyzing particular obstacles and challenges related to the implementation of this principle. Electoral systems tend to either optimize or reduce the impact of such gender parity measures. As well as with quotas, the size of the electoral district and the kind of electoral list system are the two variables that most influence the effective implementation of these measures. At the same time, the socio-cultural context also influences the process of implementation of gender parity measures. In patriarchal societies –with high levels of gender-based violence– electoral processes are often characterized by gender-based harassment and political violence, one of the greatest obstacles for increasing women’s political participation. These situations are further complicated in societies which are also characterized by ethnic and cultural diversity, presenting the challenge of including women who are also discriminated against for their ethno-cultural identity.

  20. Multi -omics and metabolic modelling pipelines: challenges and tools for systems microbiology.

    Science.gov (United States)

    Fondi, Marco; Liò, Pietro

    2015-02-01

    Integrated -omics approaches are quickly spreading across microbiology research labs, leading to (i) the possibility of detecting previously hidden features of microbial cells like multi-scale spatial organization and (ii) tracing molecular components across multiple cellular functional states. This promises to reduce the knowledge gap between genotype and phenotype and poses new challenges for computational microbiologists. We underline how the capability to unravel the complexity of microbial life will strongly depend on the integration of the huge and diverse amount of information that can be derived today from -omics experiments. In this work, we present opportunities and challenges of multi -omics data integration in current systems biology pipelines. We here discuss which layers of biological information are important for biotechnological and clinical purposes, with a special focus on bacterial metabolism and modelling procedures. A general review of the most recent computational tools for performing large-scale datasets integration is also presented, together with a possible framework to guide the design of systems biology experiments by microbiologists. Copyright © 2015. Published by Elsevier GmbH.

  1. The challenges of teaching geographical information systems integrated into the management of environment and natural resources

    International Nuclear Information System (INIS)

    Escobar, John; Betancur, Teresita; Palacio, Carlos

    2008-01-01

    The Geographic Information Systems, GIS, have the potential to become tools and methodologies for the solution of practical problems that involve complex spatial analyses, like the associated with natural resources and environmental management areas. The university, with its postgraduate programs, can help with the social adaptation processes for this new technology and can contribute to achieve the success sooner and with more effectiveness. To do so, three main challenges must be reached in the users of this technology: first, a spatial thinking second, skills to design and to make use of this instrument as supporting in environmental and natural resources analyses and finally, the identification of strategies to use this technology in projects and corporative surroundings. The Antioquia University in its Engineering Faculty (at first, in agreement with the Education Faculty)developed a Specialization in Environment and Geoinformatic. In this, the curriculum is worked in three moments (one for each challenge): first, a moment to building a common language and to adopting conceptual and technical instruments? second, a moment to put together instruments and methods and finally, a moment to make the practical application of the environmental management supported in the geo information spatial systems. This article gives account of this institutional experience.

  2. Challenge for knowledge information processing systems (preliminary report on Fifth Generation Computer Systems)

    Energy Technology Data Exchange (ETDEWEB)

    Moto-oka, T

    1982-01-01

    The author explains the reasons, aims and strategies for the Fifth Generation Computer Project in Japan. The project aims to introduce a radical new breed of computer by 1990. This article outlines the economic and social reasons for the project. It describes the impacts and effects that these computers are expected to have. The areas of technology which will form the contents of the research and development are highlighted. These are areas such as VLSI technology, speech and image understanding systems, artificial intelligence and advanced architecture design. Finally a schedule for completion of research is given which aims for a completed project by 1990.

  3. Challenges in Gaining Large Scale Carbon Reductions through Wireless Home Automation Systems

    DEFF Research Database (Denmark)

    Larsen, Peter Gorm; Rovsing, Poul Ejnar; Toftegaard, Thomas Skjødeberg

    2010-01-01

    Buildings account for more than a 35 % of the energy consumption in Europe. Therefore a step towards more sustainable lifestile is to use home automation to optimize the energy consumption “automatically”. This paper reports about the usage and some of the remaining challenges of especially...... wireless but also powerline communication in a home automation setting. For many years, home automation has been visible to many, but accessible to only a few, because of inadequate integration of systems. A vast number of both standard and proprietary communication protocols are used, and systems...... are often difficult to install and configure so professional assistance is needed. In this paper we report about our experience in constructing an open universal home automation framework enabling interoperability of multiple communication protocols. The framework can easily be expanded in order to support...

  4. Overview of the main challenges for the engineering design of the test facilities system of IFMIF

    International Nuclear Information System (INIS)

    Molla, J.; Nakamura, K.

    2009-01-01

    High intense radiation fields were demanded to IFMIF to address the lack of information on effects in materials due to radiation fields with fusion reactor features. Such intense radiation fields will also produce a number of unwanted effects in exposed materials and components. The main difficulties to achieve a reliable engineering design of the Test Facilities System during the Engineering Validation and the Engineering Design phase of IFMIF now under development are reviewed in this paper. The most challenging activities will be the design of the high flux test module, the creep fatigue test module, the test cell and the remote handling system. The intense radiation fields in the irradiation area and the high availability required for IFMIF (70%) are the main reasons for these difficulties.

  5. Unmanned Aerial Aircraft Systems for transportation engineering: Current practice and future challenges

    Directory of Open Access Journals (Sweden)

    Emmanouil N. Barmpounakis

    2016-10-01

    Full Text Available Acquiring and processing video streams from static cameras has been proposed as one of the most efficient tools for visualizing and gathering traffic information. With the latest advances in technology and visual media, combined with the increased needs in dealing with congestion more effectively and directly, the use of Unmanned Aerial Aircraft Systems (UAS has emerged in the field of traffic engineering. In this paper, we review studies and applications that incorporate UAS in transportation research and practice with the aim to set the grounds from the proper understanding and implementation of UAS related surveillance systems in transportation and traffic engineering. The studies reviewed are categorized in different transportation engineering areas. Additional significant applications from other research fields are also referenced to identify other promising applications. Finally, issues and emerging challenges in both a conceptual and methodological level are revealed and discussed.

  6. Challenges and opportunities in providing a digital protection system for the PBMR - HTR2008-58173

    International Nuclear Information System (INIS)

    Marais, J.; Ridolfo, C. F.

    2008-01-01

    , key design specifications, architectural configuration, design and implementation challenges, and unique opportunities that are provided by this type of Protection System. Copyright ASME 2008. (authors)

  7. RAVONSICS-challenging for assuring software reliability of nuclear I and C system

    International Nuclear Information System (INIS)

    Hai Zeng; Ming Yang; Yoshikawa, Hidekazu

    2015-01-01

    As the “central nerve system”, the highly reliable Instrumentation and Control (I and C) systems, which provide the right functions and functions correctly, are always desirable not only for the end users of NPPs but also the suppliers of I and C systems. The Digitalization of nuclear I and C system happened in recent years brought a lot of new features for nuclear I and C system. On one side digital technology provides more functionalities, and it should be more reliable and robust; on the other side, digital technology brings new challenge for nuclear I and C system, especially the software running in the hardware component. The software provides flexible functionalities for nuclear I and C system, but it also brings the difficulties to evaluate the reliability and safety of it because of the complexity of software. The reliability of software, which is indispensable part of I and C system, will have essential impact on the reliability of the whole system, and people definitely want to know what the reliability of this intangible part is. The methods used for the evaluation of reliability of system and hardware hardly work for software, because the inherent difference of failure mechanism exists between software and hardware. Failure in software is systematically induced by design error, but failure in hardware is randomly induced by material and production. To continue the effort on this hot topic and to try to achieve consensus on the potential methodology for software reliability evaluation, a cooperative research project called RAVONSICS (Reliability and Verification and Validation of Nuclear Safety I and C Software) is being carried on by 7 Chinese partners, which includes University, research institute, utility, vendor, and safety regulatory body. The objective of RAVONSICS is to bring forwards the methodology for the software reliability evaluation, and the software verification technique. RAVONSICS works cooperatively with its European sister project

  8. Challenges of the Unemployment Protection System and Active Policies in Spain

    Directory of Open Access Journals (Sweden)

    Del Pino, Eloísa

    2015-02-01

    Full Text Available The NorSpaR project aims to analyse the main public policy initiatives by which Norway and Spain cope with the new social and economic challenges derived from the so-called New Social Risks (NSR. Although both countries present significant differences in their institutional settings (such as Spanish EU membership, or its belonging to diverse welfare regimes types (Norway is generally included in the Nordic regime, while Spain is part of the Mediterranean one, both countries share a common interest in addressing the aforementioned challenges while maintaining social cohesion. In the last decade, governments in both countries have tried to respond to those challenges by reforming their labour markets, adapting their unemployment schemes, as well as their gender, family and long-term care policies. The analysis covered in this project includes three areas of public policy addressing NSR. First, dependency is one of the most daunting challenges for post-industrial societies experiencing population ageing and with an increasing number of frail people in need of care. This situation is forcing governments to rethink their long-term care policies. Second, family and gender public programs need to respond to the growing difficulties of families in reconciling professional and family life. Third, in the transition to a post-industrial order, and in a context of mass unemployment, social protection systems have a renewed prominence. Along with the so-called passive policies offering financial support to the unemployed, active labour market policies are geared to put people back into work. In our analysis we try to find answers to the following questions: What are the challenges that each of these policies have been trying to address in recent years? How have these policies evolved? What kinds of reforms have been implemented, and which ones have been neglected? Have the policy goals and targets of welfare programs been modified in any significant way

  9. When health systems are barriers to health care: challenges faced by uninsured Mexican kidney patients.

    Science.gov (United States)

    Kierans, Ciara; Padilla-Altamira, Cesar; Garcia-Garcia, Guillermo; Ibarra-Hernandez, Margarita; Mercado, Francisco J

    2013-01-01

    Chronic Kidney Disease disproportionately affects the poor in Low and Middle Income Countries (LMICs). Mexico exemplifies the difficulties faced in supporting Renal Replacement Therapy (RRT) and providing equitable patient care, despite recent attempts at health reform. The objective of this study is to document the challenges faced by uninsured, poor Mexican families when attempting to access RRT. The article takes an ethnographic approach, using interviewing and observation to generate detailed accounts of the problems that accompany attempts to secure care. The study, based in the state of Jalisco, comprised interviews with patients, their caregivers, health and social care professionals, among others. Observations were carried out in both clinical and social settings. In the absence of organised health information and stable pathways to renal care, patients and their families work extraordinarily hard and at great expense to secure care in a mixed public-private healthcare system. As part of this work, they must navigate challenging health and social care environments, negotiate treatments and costs, resource and finance healthcare and manage a wide range of formal and informal health information. Examining commonalities across pathways to adequate healthcare reveals major failings in the Mexican system. These systemic problems serve to reproduce and deepen health inequalities. A system, in which the costs of renal care are disproportionately borne by those who can least afford them, faces major difficulties around the sustainability and resourcing of RRTs. Attempts to increase access to renal therapies, therefore, need to take into account the complex social and economic demands this places on those who need access most. This paper further shows that ethnographic studies of the concrete ways in which healthcare is accessed in practice provide important insights into the plight of CKD patients and so constitute an important source of evidence in that effort.

  10. 3D-TV System with Depth-Image-Based Rendering Architectures, Techniques and Challenges

    CERN Document Server

    Zhao, Yin; Yu, Lu; Tanimoto, Masayuki

    2013-01-01

    Riding on the success of 3D cinema blockbusters and advances in stereoscopic display technology, 3D video applications have gathered momentum in recent years. 3D-TV System with Depth-Image-Based Rendering: Architectures, Techniques and Challenges surveys depth-image-based 3D-TV systems, which are expected to be put into applications in the near future. Depth-image-based rendering (DIBR) significantly enhances the 3D visual experience compared to stereoscopic systems currently in use. DIBR techniques make it possible to generate additional viewpoints using 3D warping techniques to adjust the perceived depth of stereoscopic videos and provide for auto-stereoscopic displays that do not require glasses for viewing the 3D image.   The material includes a technical review and literature survey of components and complete systems, solutions for technical issues, and implementation of prototypes. The book is organized into four sections: System Overview, Content Generation, Data Compression and Transmission, and 3D V...

  11. Front-end electronics and trigger systems-Status and challenges

    International Nuclear Information System (INIS)

    Spieler, Helmuth

    2007-01-01

    The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not reduce the power required for the desired noise levels, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems, they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

  12. Emerging research in micro and nano systems: opportunities and challenges for societal impact

    Science.gov (United States)

    Gianchandani, Yogesh B.

    2010-02-01

    In just a few decades, micro and nano technologies have changed the way that we live - how we work and communicate; the food and medicine that we consume; the clothing that we use; and the entertainment that we seek. While these technologies are being actively investigated in several research communities, the potential for continued societal impact is constrained by resources available for system-level research. Given the long time-lines and levels of investment that are typically necessary to develop functional systems, strategic prioritization of research directions from the perspective of societal needs can be helpful. This paper outlines the findings of an NSF-sponsored road-mapping workshop that was held in 2009, with the intention of initiating a conversation about the opportunities and challenges for micro and nano systems. Four areas of need were discussed: environmental sensing; health care; infrastructure monitoring; and energy alternatives. Possible research trajectories were identified by envisioning technological goals for the year 2040, and linking these to horizons for 2015 and 2025. This paper also provides few examples of current research in each of the four application domains. It is noted that a systems perspective can help to keep the research focused, accelerating and amplifying the societal gain with available resources. Practical and affordable solutions at the system level will require partnerships between specialists, and also between academia and industry.

  13. Human practice in the life cycle of complex systems. Challenges and methods

    Energy Technology Data Exchange (ETDEWEB)

    Nuutinen, M. (ed.) [VTT Building and Transport, Espoo (Finland); Luoma, J. (ed.) [VTT Industrial Systems, Espoo (Finland)

    2005-12-15

    This book describes the current and near future challenges in work and traffic environments in light of the rapid technology development. It focuses on the following domains: road and vessel traffic, nuclear power production, automatic mining, steel factory and the pulp and paper industry. Each example concerns complex technical systems where human practice and behaviour has an important role for the safety, efficiency and productivity of the system. The articles illustrate the enormous field of humanrelated research when considering the design, validation, implementation, operation and maintenance of complex sociotechnical systems. Nevertheless, these 14 chapters are only examples of the range of questions related to the issue. The authors of the book are VTT experts in work or traffic psychology and research, system usability, risk and safety analysis, virtual environments and they have experience in studying different domains. This book is an attempt to open up the complex world of human-technology interaction for readers facing practical problems with complex systems. It is aimed to help a technical or organisational designer, a policy- maker, an expert or a user, the one who works or lives within the technology. (orig.)

  14. Human practice in the life cycle of complex systems. Challenges and methods

    International Nuclear Information System (INIS)

    Nuutinen, M.; Luoma, J.

    2005-12-01

    This book describes the current and near future challenges in work and traffic environments in light of the rapid technology development. It focuses on the following domains: road and vessel traffic, nuclear power production, automatic mining, steel factory and the pulp and paper industry. Each example concerns complex technical systems where human practice and behaviour has an important role for the safety, efficiency and productivity of the system. The articles illustrate the enormous field of human-related research when considering the design, validation, implementation, operation and maintenance of complex sociotechnical systems. Nevertheless, these 14 chapters are only examples of the range of questions related to the issue. The authors of the book are VTT experts in work or traffic psychology and research, system usability, risk and safety analysis, virtual environments and they have experience in studying different domains. This book is an attempt to open up the complex world of human-technology interaction for readers facing practical problems with complex systems. It is aimed to help a technical or organisational designer, a policy-maker, an expert or 'a user', the one who works or lives within the technology. (orig.)

  15. The Challenges Associated with Accounting for the Army's Force Provider (FP) System when Deployed in Support of Military Operations

    National Research Council Canada - National Science Library

    Correia, Carlos A; Horner, Allen; McLaughlin, James; Stewardson, Donald

    2008-01-01

    .... The analysis will address the inherent challenges associated with accountability of the FP System when deployed and decommissioned to undergo RESET, the lack of a singular management and decision...

  16. Challenges in the management of gas voids in safety related systems

    International Nuclear Information System (INIS)

    Ezekoye, L.I.; Turkowski, W.M.; Ferraraccio, F.P.; Swartz, M.M.

    2009-01-01

    of mechanisms, such as maintenance, gas desorption, vortex activities, cavitation, etc. This paper discusses the sources of gas into safety related systems and the challenges associated with management of gas voids in these systems. Various issues such as gas monitoring, gas purging, gas transport characterization in piping, gas ingestion in safety related pumps, water hammer in discharge piping, and gas impact on the core cooling during design basis accidents are discussed. Industry efforts to support the management of gases in these systems are also presented

  17. Challenges in the management of gas voids in safety related systems

    Energy Technology Data Exchange (ETDEWEB)

    Ezekoye, L.I.; Turkowski, W.M.; Ferraraccio, F.P.; Swartz, M.M. [Westinghouse Electric Company LLC, Pittsburgh (United States)

    2009-04-15

    a number of mechanisms, such as maintenance, gas desorption, vortex activities, cavitation, etc. This paper discusses the sources of gas into safety related systems and the challenges associated with management of gas voids in these systems. Various issues such as gas monitoring, gas purging, gas transport characterization in piping, gas ingestion in safety related pumps, water hammer in discharge piping, and gas impact on the core cooling during design basis accidents are discussed. Industry efforts to support the management of gases in these systems are also presented.

  18. Model Based Reasoning by Introductory Students When Analyzing Earth Systems and Societal Challenges

    Science.gov (United States)

    Holder, L. N.; Herbert, B. E.

    2014-12-01

    Understanding how students use their conceptual models to reason about societal challenges involving societal issues such as natural hazard risk assessment, environmental policy and management, and energy resources can improve instructional activity design that directly impacts student motivation and literacy. To address this question, we created four laboratory exercises for an introductory physical geology course at Texas A&M University that engages students in authentic scientific practices by using real world problems and issues that affect societies based on the theory of situated cognition. Our case-study design allows us to investigate the various ways that students utilize model based reasoning to identify and propose solutions to societally relevant issues. In each of the four interventions, approximately 60 students in three sections of introductory physical geology were expected to represent and evaluate scientific data, make evidence-based claims about the data trends, use those claims to express conceptual models, and use their models to analyze societal challenges. Throughout each step of the laboratory exercise students were asked to justify their claims, models, and data representations using evidence and through the use of argumentation with peers. Cognitive apprenticeship was the foundation for instruction used to scaffold students so that in the first exercise they are given a partially completed model and in the last exercise students are asked to generate a conceptual model on their own. Student artifacts, including representation of earth systems, representation of scientific data, verbal and written explanations of models and scientific arguments, and written solutions to specific societal issues or environmental problems surrounding earth systems, were analyzed through the use of a rubric that modeled authentic expertise and students were sorted into three categories. Written artifacts were examined to identify student argumentation and

  19. Costs and epidemiological changes of chronic diseases: implications and challenges for health systems.

    Science.gov (United States)

    Arredondo, Armando; Aviles, Raul

    2015-01-01

    The need to integrate economic and epidemiological aspects in the clinical perspective leads to a proposal for the analysis of health disparities and to an evaluation of the health services and of the new challenges which are now being faced by health system reforms in middle income countries. To identify the epidemiological changes, the demand for health services and economic burden from chronic diseases (diabetes and hypertension) in a middle income county. We conducted longitudinal analyses of costs and epidemiological changes for diabetes and hypertension in the Mexican health system. The study population included both the insured and uninsured populations. The cost-evaluation method was used, based on the instrumentation and consensus techniques. To estimate the epidemiological changes and financial consequences for 2014-2016, six models were constructed according to the Box-Jenkins technique, using confidence intervals of 95%, and the Box-Pierce test. Regarding epidemiological changes expected in both diseases for 2014 vs. 2016, an increase is expected, although results predict a greater increase for diabetes, 8-12% in all three studied institutions, (p management per patient in the case of diabetes, and from $485 to $622 in patients with hypertension. Comparing financial consequences of health services required by insured and uninsured populations, the greater increase (23%) will be for the insured population (p financial requirements of both diseases will amount to 19.5% of the total budget for the uninsured and 12.5% for the insured population. If the risk factors and the different health care models remain as they currently are, the economic impact of expected epidemiological changes on the social security system will be particularly strong. Another relevant challenge is the appearance of internal competition in the use and allocation of financial resources with programs for other chronic and infectious diseases.

  20. Integration of community health workers into health systems in developing countries: Opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Collins Otieno Asweto

    2016-02-01

    Full Text Available Background: Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health workers (CHWs. It is imperative that health care systems focus on improving access to quality continuous primary care through the use of CHWs while paying attention to the factors that impact on CHWs and their effectiveness. Objective: To explore the possible opportunities and challenges of integrating CHWs into the health care systems of developing countries. Methods: Six databases were examined for quantitative, qualitative, and mixed-methods studies that included the integration of CHWs, their motivation and supervision, and CHW policy making and implementation in developing countries. Thirty-three studies met the inclusion criteria and were double read to extract data relevant to the context of CHW programs. Thematic coding was conducted and evidence on the main categories of contextual factors influencing integration of CHWs into the health system was synthesized. Results: CHWs are an effective and appropriate element of a health care team and can assist in addressing health disparities and social determinants of health. Important facilitators of integration of CHWs into health care teams are support from other health workers and inclusion of CHWs in case management meetings. Sustainable integration of CHWs into the health care system requires the formulation and implementation of polices that support their work, as well as financial and nonfinancial incentives, motivation, collaborative and supportive supervision, and a manageable workload. Conclusions: For sustainable integration of CHWs into health care systems, high-performing health systems with sound governance, adequate financing, well-organized service delivery, and adequate supplies and equipment are essential. Similarly, competent communities could contribute to better CHW performance through sound

  1. Multiple-use Management of Irrigation Systems: Technical Constraints and Challenges

    Science.gov (United States)

    Gowing, J.; Li, Q.; Mayilswami, C.; Gunawardhana, K.

    selected distributary commands combined with longitudinal studies based on available long- term data from the full command. The reliability and duration of flows and/or storages represent a constraint to effective integration of aquaculture within the case-study sys- tems. Although fish production is non-consumptive and can be seen as a complemen- tary use of irrigation water, the challenge is to devise operating procedures that will 1 guarantee reliability and duration of flows and/or storages for fish production without increasing total water-use within the system. This is a particular problem during the rainy season when irrigation demand fluctuates widely and rapidly. The problem is ex- acerbated by deficient information systems, which constrain the scope for responsive management in these extensive canal systems. 2

  2. Technological incorporation in the Unified Health System (SUS: the problem and ensuing challenges

    Directory of Open Access Journals (Sweden)

    Reinaldo Guimarães

    2014-12-01

    Full Text Available Technological incorporation is a central topic among the concerns regarding health care systems. This paper discusses the role of technology dynamics in health systems' cost increases, suggesting two different approaches - a 'pragmatic-economic' approach and a 'rational-defensive' approach - as guidelines to explain the reasons for this centrality. The paper shows how judicialization results from this situation and discusses two doctrinal views - 'reserve for contingencies' and 'rational use' - as the views that usually guide the debates in the courts and among health policy makers. The paper suggests that the attitude currently prevalent in the Brazilian judiciary system can prejudice the principle of equity by improperly evaluating the principle of integrality. We present a brief genealogy of HTA and a timeline of HTA in Brazil. We also discuss the relevance and the impact of Law 12401/2011, which regulates the principle of integrality in the Unified Health System (SUS and propose three challenges to the development of HTA actions aiming at technology incorporation in Brazil. Finally, we discuss the entry and the role of private health insurance companies, emphasizing changes in the scenario and in their position.

  3. LOCAL FOOD SYSTEMS DEVELOPMENT IN THE REPUBLIC OF MOLDOVA: CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Victor MOROZ

    2013-01-01

    Full Text Available The main challenge of the food sector in the Republic of Moldova is to identify specific needs and opportunities for agriculture and rural development throughout food supply chains, and focusing investment in areas where the most impact will be made. The identification and allocation of resources requires analysis of main dimensions of food supply chains, in order to establish links and determine local factors. In small transition economies the diagnosis of the food supply chains, is typically based on limited data and incomplete information. In order to investigate the actual state of food supply chains were used specific methods and techniques: statistical and economic analysis of macro-economic indicators, semi-structured interviews of key stakeholders, analysis of the impact of public policies on the agro-food sector. In the article is analyzed the process of food systems formation and integration at the local and global level. Although it is a small part of the overall agricultural sector, various local food systems are under development in the Republic of Moldova. These systems bring consumers in close contact with farmers and mobilize them to support local farms and sustainable farming practices. While local food systems continue to face many barriers, many of them show considerable potential for growth.

  4. Development of oral food-grade delivery systems: current knowledge and future challenges.

    Science.gov (United States)

    Benshitrit, Revital Cohen; Levi, Carmit Shani; Tal, Sharon Levi; Shimoni, Eyal; Lesmes, Uri

    2012-01-01

    In recent years there has been an increasing interest in the development of new and efficient oral food delivery systems as tools to prevent disease and promote human health and well-being. Such vehicles are sought to protect bioactive ingredients added to food while controlling and targeting their release as they pass through the human gastrointestinal tract (GIT). This review aims to summarize the key concepts of food delivery systems, their characterization and evaluation. Particularly, evaluation of their performance within the human GIT is discussed. To this end an overview of several in vivo and in vitro methods currently applied for the study of such systems is given. Although considered to be still in its infancy, this promising field of research is likely to infiltrate into real products through rational design. In order for such efforts to materialize into real products some challenges still need to be met and are discussed herein. Overall, it seems that adopting a comprehensive pharmacological approach and relevant cutting edge tools are likely to facilitate innovations and help elucidate and perhaps tailor delivery systems' behavior in the human GIT.

  5. Lead-Cooled Fast Reactor Systems and the Fuels and Materials Challenges

    Directory of Open Access Journals (Sweden)

    T. R. Allen

    2007-01-01

    Full Text Available Anticipated developments in the consumer energy market have led developers of nuclear energy concepts to consider how innovations in energy technology can be adapted to meet consumer needs. Properties of molten lead or lead-bismuth alloy coolants in lead-cooled fast reactor (LFR systems offer potential advantages for reactors with passive safety characteristics, modular deployment, and fuel cycle flexibility. In addition to realizing those engineering objectives, the feasibility of such systems will rest on development or selection of fuels and materials suitable for use with corrosive lead or lead-bismuth. Three proposed LFR systems, with varying levels of concept maturity, are described to illustrate their associated fuels and materials challenges. Nitride fuels are generally favored for LFR use over metal or oxide fuels due to their compatibility with molten lead and lead-bismuth, in addition to their high atomic density and thermal conductivity. Ferritic/martensitic stainless steels, perhaps with silicon and/or oxide-dispersion additions for enhanced coolant compatibility and improved high-temperature strength, might prove sufficient for low-to-moderate-temperature LFRs, but it appears that ceramics or refractory metal alloys will be necessary for higher-temperature LFR systems intended for production of hydrogen energy carriers.

  6. Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Sarah R. [J. Craig Venter Inst., Rockville, MD (United States); Rodemeyer, Michael [Univ. of Virginia, Charlottesville, VA (United States); Garfinkel, Michele S. [EMBO, Heidelberg (Germany); Friedman, Robert M. [J. Craig Venter Inst., Rockville, MD (United States)

    2014-05-01

    Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options Sarah R. Carter, Ph.D., J. Craig Venter Institute; Michael Rodemeyer, J.D., University of Virginia; Michele S. Garfinkel, Ph.D., EMBO; Robert M. Friedman, Ph.D., J. Craig Venter Institute In recent years, a range of genetic engineering techniques referred to as “synthetic biology” has significantly expanded the tool kit available to scientists and engineers, providing them with far greater capabilities to engineer organisms than previous techniques allowed. The field of synthetic biology includes the relatively new ability to synthesize long pieces of DNA from chemicals, as well as improved methods for genetic manipulation and design of genetic pathways to achieve more precise control of biological systems. These advances will help usher in a new generation of genetically engineered microbes, plants, and animals. The JCVI Policy Center team, along with researchers at the University of Virginia and EMBO, examined how well the current U.S. regulatory system for genetically engineered products will handle the near-term introduction of organisms engineered using synthetic biology. In particular, the focus was on those organisms intended to be used or grown directly in the environment, outside of a contained facility. The study concludes that the U.S. regulatory agencies have adequate legal authority to address most, but not all, potential environmental, health and safety concerns posed by these organisms. Such near-term products are likely to represent incremental changes rather than a marked departure from previous genetically engineered organisms. However, the study also identified two key challenges for the regulatory system, which are detailed in the report. First, USDA’s authority over genetically engineered plants depends on the use of an older engineering technique that is no longer necessary for many applications. The shift to synthetic biology and other newer genetic

  7. The new challenges of end-of-life tyres management systems: A Spanish case study

    International Nuclear Information System (INIS)

    Uruburu, Ángel; Ponce-Cueto, Eva; Cobo-Benita, José Ramón; Ordieres-Meré, Joaquín

    2013-01-01

    Highlights: ► Impact of the implementation of the Directive 2008/98/EC in Spain for end-of-life tyres. ► Characterization of the reverse supply chain for collecting, recovering, and treating end-of-life tyres. ► Identification of challenges to be coped and issues to be covered. ► Potential new applications for end-of-life tyres and development of new management related strategies. - Abstract: Directive 2008/98/EC released by the European Union represents a significant step forward in all relevant aspects of waste management. Under the already established, extended produced responsibility (EPR) principle, new policies have been enunciated to continuously achieve better overall environmental performance of key products throughout their life phases. This paper discusses how the directive is being articulated in Spain by the main integrated management system (IMS) for end-of-life (EOL) tyres since its creation in 2006. Focusing on the IMS technological, economic and legal aspects, the study provides a global perspective and evaluation of how the IMS is facing the current issues to resolve, the new challenges that have appeared and the management vision for the coming years

  8. Homebirth as systems-challenging praxis: knowledge, power, and intimacy in the birthplace.

    Science.gov (United States)

    Cheyney, Melissa J

    2008-02-01

    In this article, I examine the processes and motivations involved when women in the United States choose to circumvent the dominant obstetric care paradigm by delivering at home with a group of care providers called direct-entry midwives. Using grounded theory, participant observation, and open-ended, semistructured interviewing, I collected and analyzed homebirth narratives from a theoretical sample of women (n = 50) in two research locales. Findings interpreted from the perspective of critical medical anthropology suggest that women who choose to birth at home negotiate fears associated with the "just in case something bad happens" argument that forms the foundation for hospital birth rationales through complex individual and social processes. These involve challenging established forms of authoritative knowledge, valuing alternative and more embodied or intuitive ways of knowing, and knowledge sharing through the informed consent process. Adherence to subjugated discourses combined with lived experiences of personal power and the cultivation of intimacy in the birthplace fuel homebirth not only as a minority social movement, but also as a form of systems-challenging praxis.

  9. Clinical decision support systems in hospital care using ubiquitous devices: Current issues and challenges.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Moqeem, Aasia A; Mirza, Farhaan; Lindén, Maria

    2017-11-01

    Supporting clinicians in decision making using advanced technologies has been an active research area in biomedical engineering during the past years. Among a wide range of ubiquitous systems, smartphone applications have been increasingly developed in healthcare settings to help clinicians as well as patients. Today, many smartphone applications, from basic data analysis to advanced patient monitoring, are available to clinicians and patients. Such applications are now increasingly integrating into healthcare for clinical decision support, and therefore, concerns around accuracy, stability, and dependency of these applications are rising. In addition, lack of attention to the clinicians' acceptability, as well as the low impact on the medical professionals' decision making, are posing more serious issues on the acceptability of smartphone applications. This article reviews smartphone-based decision support applications, focusing on hospital care settings and their overall impact of these applications on the wider clinical workflow. Additionally, key challenges and barriers of the current ubiquitous device-based healthcare applications are identified. Finally, this article addresses current challenges, future directions, and the adoption of mobile healthcare applications.

  10. The new challenges of end-of-life tyres management systems: A Spanish case study

    Energy Technology Data Exchange (ETDEWEB)

    Uruburu, Ángel, E-mail: angel.uruburu@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Ponce-Cueto, Eva, E-mail: eva.ponce@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Center for Transportation and Logistics, Massachusetts Institute of Technology, Cambridge, MA (United States); Cobo-Benita, José Ramón, E-mail: joseramon.cobo@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Ordieres-Meré, Joaquín, E-mail: j.ordieres@upm.es [Industrial Management Department, Technical University of Madrid, C/José Gutiérrez Abascal, 2, 28006 Madrid (Spain)

    2013-03-15

    Highlights: ► Impact of the implementation of the Directive 2008/98/EC in Spain for end-of-life tyres. ► Characterization of the reverse supply chain for collecting, recovering, and treating end-of-life tyres. ► Identification of challenges to be coped and issues to be covered. ► Potential new applications for end-of-life tyres and development of new management related strategies. - Abstract: Directive 2008/98/EC released by the European Union represents a significant step forward in all relevant aspects of waste management. Under the already established, extended produced responsibility (EPR) principle, new policies have been enunciated to continuously achieve better overall environmental performance of key products throughout their life phases. This paper discusses how the directive is being articulated in Spain by the main integrated management system (IMS) for end-of-life (EOL) tyres since its creation in 2006. Focusing on the IMS technological, economic and legal aspects, the study provides a global perspective and evaluation of how the IMS is facing the current issues to resolve, the new challenges that have appeared and the management vision for the coming years.

  11. Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges.

    Science.gov (United States)

    Albanese, Chris; Rodriguez, Olga C; VanMeter, John; Fricke, Stanley T; Rood, Brian R; Lee, YiChien; Wang, Sean S; Madhavan, Subha; Gusev, Yuriy; Petricoin, Emanuel F; Wang, Yue

    2013-02-01

    Biologically accurate mouse models of human cancer have become important tools for the study of human disease. The anatomical location of various target organs, such as brain, pancreas, and prostate, makes determination of disease status difficult. Imaging modalities, such as magnetic resonance imaging, can greatly enhance diagnosis, and longitudinal imaging of tumor progression is an important source of experimental data. Even in models where the tumors arise in areas that permit visual determination of tumorigenesis, longitudinal anatomical and functional imaging can enhance the scope of studies by facilitating the assessment of biological alterations, (such as changes in angiogenesis, metabolism, cellular invasion) as well as tissue perfusion and diffusion. One of the challenges in preclinical imaging is the development of infrastructural platforms required for integrating in vivo imaging and therapeutic response data with ex vivo pathological and molecular data using a more systems-based multiscale modeling approach. Further challenges exist in integrating these data for computational modeling to better understand the pathobiology of cancer and to better affect its cure. We review the current applications of preclinical imaging and discuss the implications of applying functional imaging to visualize cancer progression and treatment. Finally, we provide new data from an ongoing preclinical drug study demonstrating how multiscale modeling can lead to a more comprehensive understanding of cancer biology and therapy. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  12. Coupled Data Assimilation for Integrated Earth System Analysis and Prediction: Goals, Challenges, and Recommendations

    Science.gov (United States)

    Penny, Stephen G.; Akella, Santha; Buehner, Mark; Chevallier, Matthieu; Counillon, Francois; Draper, Clara; Frolov, Sergey; Fujii, Yosuke; Karspeck, Alicia; Kumar, Arun

    2017-01-01

    The purpose of this report is to identify fundamental issues for coupled data assimilation (CDA), such as gaps in science and limitations in forecasting systems, in order to provide guidance to the World Meteorological Organization (WMO) on how to facilitate more rapid progress internationally. Coupled Earth system modeling provides the opportunity to extend skillful atmospheric forecasts beyond the traditional two-week barrier by extracting skill from low-frequency state components such as the land, ocean, and sea ice. More generally, coupled models are needed to support seamless prediction systems that span timescales from weather, subseasonal to seasonal (S2S), multiyear, and decadal. Therefore, initialization methods are needed for coupled Earth system models, either applied to each individual component (called Weakly Coupled Data Assimilation - WCDA) or applied the coupled Earth system model as a whole (called Strongly Coupled Data Assimilation - SCDA). Using CDA, in which model forecasts and potentially the state estimation are performed jointly, each model domain benefits from observations in other domains either directly using error covariance information known at the time of the analysis (SCDA), or indirectly through flux interactions at the model boundaries (WCDA). Because the non-atmospheric domains are generally under-observed compared to the atmosphere, CDA provides a significant advantage over single-domain analyses. Next, we provide a synopsis of goals, challenges, and recommendations to advance CDA: Goals: (a) Extend predictive skill beyond the current capability of NWP (e.g. as demonstrated by improving forecast skill scores), (b) produce physically consistent initial conditions for coupled numerical prediction systems and reanalyses (including consistent fluxes at the domain interfaces), (c) make best use of existing observations by allowing observations from each domain to influence and improve the full earth system analysis, (d) develop a robust

  13. Progresses and challenges in supporting activities toward a license to operate European TBM systems in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Poitevin, Y., E-mail: yves.poitevin@f4e.europa.eu [Fusion for Energy, Barcelona (Spain); Ricapito, I.; Zmitko, M. [Fusion for Energy, Barcelona (Spain); Tavassoli, F. [CEA, DEN, F-91191 Gif-sur-Yvette (France); Thomas, N. [ATMOSTAT, F-94815 Villejuif (France); De Dinechin, G. [CEA, DEN, F-91191 Gif-sur-Yvette (France); Bucci, Ph. [CEA DRT, 38000 Grenoble (France); Rey, J. [Karlsruhe Institute of Technology, Postfach 3640, Karlsruhe (Germany); Ibarra, A. [CIEMAT, Madrid (Spain); Panayotov, D. [Fusion for Energy, Barcelona (Spain); Giancarli, L. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); Calderoni, P.; Galabert, J.; Vallory, J. [Fusion for Energy, Barcelona (Spain); Aiello, A. [C.R. ENEA Brasimone, I-40032 Camugnano (Italy)

    2014-10-15

    Highlights: • First EUROFER steel design limits have been introduced in RCC-MRx. • Preliminary fabrication/welding procedure specifications for the European TBM box are under standardization. • Post irradiation examination (PIE) of beryllium pebbles irradiated at 17% of DEMO fluence target has been achieved. • Dynamic modeling of the TBM Systems with EcosimPro{sup ®} has been developed. - Abstract: Licensing a pressurized nuclear equipment like the European Test Blanket Modules (TBM) Systems and, on the longer term, breeder blankets of a fusion demonstration reactor (DEMO), will require presenting to the Regulator and the Agreed Notified Body, along with design and safety analyses, supporting data like consolidated materials data and design limits, qualified fabrication procedures specifications and validated modeling tools that go often over today's state-of-the-art of nuclear industry. TBM systems feature indeed a newly developed structural material and advanced fabrication processes that were not referenced in any nuclear construction codes before, new type of functional materials, complex structures geometry and many interconnected sub-systems exchanging tritium by permeation or fluid mass transfer. For many years now, Europe has structured its development activities on TBM Systems toward the preparation of licensing. First tangible results are now arising: the EUROFER structural material has been introduced in the RCC-MRx nuclear code, supported by a database of several thousands of test records; TBM box fabrication procedure specifications are under standardization by industry in view of their qualification; a modeling tool for accurate simulation of tritium transport in TBM systems has been developed in view of refining conservative inventory data published in preliminary safety reports and optimizing waste management. Remaining challenges are identified and discussed.

  14. External cues challenging the internal appetite control system-Overview and practical implications.

    Science.gov (United States)

    Bilman, Els; van Kleef, Ellen; van Trijp, Hans

    2017-09-02

    Inadequate regulation of food intake plays an important role in the development of overweight and obesity, and is under the influence of both the internal appetite control system and external environmental cues. Especially in environments where food is overly available, external cues seem to override and/or undermine internal signals, which put severe challenges on the accurate regulation of food intake. By structuring these external cues around five different phases in the food consumption process this paper aims to provide an overview of the wide range of external cues that potentially facilitate or hamper internal signals and with that influence food intake. For each of the five phases of the food consumption process, meal initiation, meal planning, consumption phase, end of eating episode and time till next meal, the most relevant internal signals are discussed and it is explained how specific external cues exert their influence.

  15. Facing the challenges of distribution systems operation with high wind power penetration

    DEFF Research Database (Denmark)

    Das, Kaushik; Altin, Müfit; Hansen, Anca Daniela

    2017-01-01

    power flow in 60kV distribution networks through controlling the ability of wind power plants (WPPs) to generate or absorb reactive power. This paper aims to understand the characteristics of a distribution network with high penetration of distributed generation. A detailed analysis of the active...... and reactive power flows in a real distribution network under different wind and load conditions based on actual measurements is performed in order to understand the correlation between the consumption, wind power production, and the network losses. Conclusive remarks are presented, briefly expressing......This paper addresses the challenges associated with the operation of a distribution system with high penetration of wind power. The paper presents some preliminary investigations of an ongoing Danish research work, which has as main objective to reduce the network losses by optimizing the reactive...

  16. Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.

    Directory of Open Access Journals (Sweden)

    Steve D M Brown

    2006-08-01

    Full Text Available Understanding mammalian genetic systems is predicated on the determination of the relationship between genetic variation and phenotype. Several international programmes are under way to deliver mutations in every gene in the mouse genome. The challenge for mouse geneticists is to develop approaches that will provide comprehensive phenotype datasets for these mouse mutant libraries. Several factors are critical to success in this endeavour. It will be important to catalogue assay and environment and where possible to adopt standardised procedures for phenotyping tests along with common environmental conditions to ensure comparable datasets of phenotypes. Moreover, the scale of the task underlines the need to invest in technological development improving both the speed and cost of phenotyping platforms. In addition, it will be necessary to develop new informatics standards that capture the phenotype assay as well as other factors, genetic and environmental, that impinge upon phenotype outcome.

  17. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Directory of Open Access Journals (Sweden)

    F. Sabath

    2004-01-01

    Full Text Available The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  18. Environmental challenges for Asian-Pacific energy systems in the 1991s

    International Nuclear Information System (INIS)

    Markham, Adam; Ramani, K.V.

    1991-01-01

    This paper provides an overview of the main issues addressed and conclusions arrived at by the Regional Conference on Environmental Challenges for Asian and Pacific Energy Systems in the 1990s', jointly organized by the Asian and Pacific Development Centre and the World Wide Fund for Nature during 14-18 January 1991 at Kuala Lumpur, Malaysia. The first part of the paper focuses on the regional and global context of the conference. This is followed by a review of the key issues that are considered relevant to the shaping of a new energy policy for the region to ensure environmental sustainability. The concluding part provides some cautionary notes and suggestions for the immediate future. (author)

  19. The challenges of connecting generation to distribution systems: a utility perspective

    International Nuclear Information System (INIS)

    Kropp, F.

    2004-01-01

    'Full text:' This presentation discusses the technical, financial and regulatory barriers to connecting generation to Distribution Systems in Ontario. Case studies will be used to provide examples of the operational and technical challenges that impact the utility as well as a discussion on the site-specific advantages and disadvantages (to the utility) of the generation connections. These studies will include discussions on the problems and lessons learned with respect to the overall project implementation and the contractual agreements. The case studies will be complemented by an explanation of the financial constraints (both short term and long term) associated with the connections, and the regulatory issues that impact the financial recovery models including net and gross load billing. (author)

  20. Reframing the challenges to integrated care: a complex-adaptive systems perspective

    Directory of Open Access Journals (Sweden)

    Peter Tsasis

    2012-09-01

    Full Text Available Introduction: Despite over two decades of international experience and research on health systems integration, integrated care has not developed widely. We hypothesized that part of the problem may lie in how we conceptualize the integration process and the complex systems within which integrated care is enacted. This study aims to contribute to discourse regarding the relevance and utility of a complex-adaptive systems (CAS perspective on integrated care.Methods: In the Canadian province of Ontario, government mandated the development of fourteen Local Health Integration Networks in 2006. Against the backdrop of these efforts to integrate care, we collected focus group data from a diverse sample of healthcare professionals in the Greater Toronto Area using convenience and snowball sampling. A semi-structured interview guide was used to elicit participant views and experiences of health systems integration. We use a CAS framework to describe and analyze the data, and to assess the theoretical fit of a CAS perspective with the dominant themes in participant responses.Results: Our findings indicate that integration is challenged by system complexity, weak ties and poor alignment among professionals and organizations, a lack of funding incentives to support collaborative work, and a bureaucratic environment based on a command and control approach to management. Using a CAS framework, we identified several characteristics of CAS in our data, including diverse, interdependent and semi-autonomous actors; embedded co-evolutionary systems; emergent behaviours and non-linearity; and self-organizing capacity. Discussion and Conclusion: One possible explanation for the lack of systems change towards integration is that we have failed to treat the healthcare system as complex-adaptive. The data suggest that future integration initiatives must be anchored in a CAS perspective, and focus on building the system's capacity to self-organize. We conclude that

  1. Reframing the challenges to integrated care: a complex-adaptive systems perspective

    Directory of Open Access Journals (Sweden)

    Peter Tsasis

    2012-09-01

    Full Text Available Introduction: Despite over two decades of international experience and research on health systems integration, integrated care has not developed widely. We hypothesized that part of the problem may lie in how we conceptualize the integration process and the complex systems within which integrated care is enacted. This study aims to contribute to discourse regarding the relevance and utility of a complex-adaptive systems (CAS perspective on integrated care. Methods: In the Canadian province of Ontario, government mandated the development of fourteen Local Health Integration Networks in 2006. Against the backdrop of these efforts to integrate care, we collected focus group data from a diverse sample of healthcare professionals in the Greater Toronto Area using convenience and snowball sampling. A semi-structured interview guide was used to elicit participant views and experiences of health systems integration. We use a CAS framework to describe and analyze the data, and to assess the theoretical fit of a CAS perspective with the dominant themes in participant responses. Results: Our findings indicate that integration is challenged by system complexity, weak ties and poor alignment among professionals and organizations, a lack of funding incentives to support collaborative work, and a bureaucratic environment based on a command and control approach to management. Using a CAS framework, we identified several characteristics of CAS in our data, including diverse, interdependent and semi-autonomous actors; embedded co-evolutionary systems; emergent behaviours and non-linearity; and self-organizing capacity.  Discussion and Conclusion: One possible explanation for the lack of systems change towards integration is that we have failed to treat the healthcare system as complex-adaptive. The data suggest that future integration initiatives must be anchored in a CAS perspective, and focus on building the system's capacity to self-organize. We conclude that

  2. Technology Transfer Challenges: A Case Study of User-Centered Design in NASA's Systems Engineering Culture

    Science.gov (United States)

    Quick, Jason

    2009-01-01

    The Upper Stage (US) section of the National Aeronautics and Space Administration's (NASA) Ares I rocket will require internal access platforms for maintenance tasks performed by humans inside the vehicle. Tasks will occur during expensive critical path operations at Kennedy Space Center (KSC) including vehicle stacking and launch preparation activities. Platforms must be translated through a small human access hatch, installed in an enclosed worksite environment, support the weight of ground operators and be removed before flight - and their design must minimize additional vehicle mass at attachment points. This paper describes the application of a user-centered conceptual design process and the unique challenges encountered within NASA's systems engineering culture focused on requirements and "heritage hardware". The NASA design team at Marshall Space Flight Center (MSFC) initiated the user-centered design process by studying heritage internal access kits and proposing new design concepts during brainstorming sessions. Simultaneously, they partnered with the Technology Transfer/Innovative Partnerships Program to research inflatable structures and dynamic scaffolding solutions that could enable ground operator access. While this creative, technology-oriented exploration was encouraged by upper management, some design stakeholders consistently opposed ideas utilizing novel, untested equipment. Subsequent collaboration with an engineering consulting firm improved the technical credibility of several options, however, there was continued resistance from team members focused on meeting system requirements with pre-certified hardware. After a six-month idea-generating phase, an intensive six-week effort produced viable design concepts that justified additional vehicle mass while optimizing the human factors of platform installation and use. Although these selected final concepts closely resemble heritage internal access platforms, challenges from the application of the

  3. Adapting a regularized canopy reflectance model (REGFLEC) for the retrieval challenges of dryland agricultural systems

    KAUST Repository

    Houborg, Rasmus

    2016-08-20

    A regularized canopy reflectance model (REGFLEC) is applied over a dryland irrigated agricultural system in Saudi Arabia for the purpose of retrieving leaf area index (LAI) and leaf chlorophyll content (Chll). To improve the robustness of the retrieved properties, REGFLEC was modified to 1) correct for aerosol and adjacency effects, 2) consider foliar dust effects on modeled canopy reflectances, 3) include spectral information in the red-edge wavelength region, and 4) exploit empirical LAI estimates in the model inversion. Using multi-spectral RapidEye imagery allowed Chll to be retrieved with a Mean Absolute Deviation (MAD) of 7.9 μg cm− 2 (16%), based upon in-situ measurements conducted in fields of alfalfa, Rhodes grass and maize over the course of a growing season. LAI and Chll compensation effects on canopy reflectance were largely avoided by informing the inversion process with ancillary LAI inputs established empirically on the basis of a statistical machine learning technique. As a result, LAI was reproduced with good accuracy, with an overall MAD of 0.42 m2 m− 2 (12.5%). Results highlighted the considerable challenges associated with the translation of at-sensor radiance observations to surface bidirectional reflectances in dryland environments, where issues such as high aerosol loadings and large spatial gradients in surface reflectance from bright desert soils to dark vegetated fields are often present. Indeed, surface reflectances in the visible bands were reduced by up to 60% after correction for such adjacency effects. In addition, dust deposition on leaves required explicit modification of the reflectance sub-model to account for its influence. By implementing these model refinements, REGFLEC demonstrated its utility for within-field characterization of vegetation conditions over the challenging landscapes typical of dryland agricultural regions, offering a means through which improvements can be made in the management of these globally

  4. Systemic challenges in bipolar disorder management: A patient-centered approach.

    Science.gov (United States)

    Nestsiarovich, Anastasiya; Hurwitz, Nathaniel G; Nelson, Stuart J; Crisanti, Annette S; Kerner, Berit; Kuntz, Matt J; Smith, Alicia N; Volesky, Emma; Schroeter, Quentin L; DeShaw, Jason L; Young, S Stanley; Obenchain, Robert L; Krall, Ronald L; Jordan, Kimmie; Fawcett, Jan; Tohen, Mauricio; Perkins, Douglas J; Lambert, Christophe G

    2017-12-01

    As part of a series of Patient-Centered Outcomes Research Institute-funded large-scale retrospective observational studies on bipolar disorder (BD) treatments and outcomes, we sought the input of patients with BD and their family members to develop research questions. We aimed to identify systemic root causes of patient-reported challenges with BD management in order to guide subsequent studies and initiatives. Three focus groups were conducted where patients and their family members (total n = 34) formulated questions around the central theme, "What do you wish you had known in advance or over the course of treatment for BD?" In an affinity mapping exercise, participants clustered their questions and ranked the resulting categories by importance. The research team and members of our patient partner advisory council further rated the questions by expected impact on patients. Using a Theory of Constraints systems thinking approach, several causal models of BD management challenges and their potential solution were developed with patients using the focus group data. A total of 369 research questions were mapped to 33 categories revealing 10 broad themes. The top priorities for patient stakeholders involved pharmacotherapy and treatment alternatives. Analysis of causal relationships underlying 47 patient concerns revealed two core conflicts: for patients, whether or not to take pharmacotherapy, and for mental health services, the dilemma of care quality vs quantity. To alleviate the core conflicts identified, BD management requires a coordinated multidisciplinary approach including: improved access to mental health services, objective diagnostics, sufficient provider visit time, evidence-based individualized treatment, and psychosocial support. © 2017 The Authors. Bipolar Disorders Published by John Wiley & Sons Ltd.

  5. Computer-assisted learning and simulation systems in dentistry--a challenge to society.

    Science.gov (United States)

    Welk, A; Splieth, Ch; Wierinck, E; Gilpatrick, R O; Meyer, G

    2006-07-01

    Computer technology is increasingly used in practical training at universities. However, in spite of their potential, computer-assisted learning (CAL) and computer-assisted simulation (CAS) systems still appear to be underutilized in dental education. Advantages, challenges, problems, and solutions of computer-assisted learning and simulation in dentistry are discussed by means of MEDLINE, open Internet platform searches, and key results of a study among German dental schools. The advantages of computer-assisted learning are seen for example in self-paced and self-directed learning and increased motivation. It is useful for both objective theoretical and practical tests and for training students to handle complex cases. CAL can lead to more structured learning and can support training in evidence-based decision-making. The reasons for the still relatively rare implementation of CAL/CAS systems in dental education include an inability to finance, lack of studies of CAL/CAS, and too much effort required to integrate CAL/CAS systems into the curriculum. To overcome the reasons for the relative low degree of computer technology use, we should strive for multicenter research and development projects monitored by the appropriate national and international scientific societies, so that the potential of computer technology can be fully realized in graduate, postgraduate, and continuing dental education.

  6. The Challenges Facing the Multilateral Trading System in Addressing Global Public Policy Objectives

    Directory of Open Access Journals (Sweden)

    Christophe Bellmann

    2013-02-01

    Full Text Available Despite a record-breaking 14.5 per cent increase in world merchandise exports, the effects of the financial crisis and global recession are still hampering faster economic recovery. Relatively high oil prices combined with persistent unemployment and measures designed to reduce budget deficits have undermined short-term growth prospects. While South–South trade continues to explode, trade imbalances – i.e. the gap between exports and imports – widened in 2010 compared to 2009 (though smaller than pre-crisis levels. Meanwhile, trade negotiations under the Doha Round have reached an impasse, generating uncertainties about the future of the World Trade Organization (WTO as a negotiating forum. Under these circumstances, should the system rethink its decision-making process founded upon the predominance of member states, the principle of consensus and the notion of single undertaking, as some critics have suggested? And, if so, how could such a reform agenda be initiated at the WTO? Moreover, beyond the negotiating function of the WTO, the paralysis of the system also raises urgent questions about the ability of the system to respond to pressing challenges of our times, such as trade and climate change, or food security and price volatility.

  7. Challenges in reducing the computational time of QSTS simulations for distribution system analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Deboever, Jeremiah [Georgia Inst. of Technology, Atlanta, GA (United States); Zhang, Xiaochen [Georgia Inst. of Technology, Atlanta, GA (United States); Reno, Matthew J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grijalva, Santiago [Georgia Inst. of Technology, Atlanta, GA (United States); Therrien, Francis [CME International T& D, St. Bruno, QC (Canada)

    2017-06-01

    The rapid increase in penetration of distributed energy resources on the electric power distribution system has created a need for more comprehensive interconnection modelling and impact analysis. Unlike conventional scenario - based studies , quasi - static time - series (QSTS) simulation s can realistically model time - dependent voltage controllers and the diversity of potential impacts that can occur at different times of year . However, to accurately model a distribution system with all its controllable devices, a yearlong simulation at 1 - second resolution is often required , which could take conventional computers a computational time of 10 to 120 hours when an actual unbalanced distribution feeder is modeled . This computational burden is a clear l imitation to the adoption of QSTS simulation s in interconnection studies and for determining optimal control solutions for utility operations . Our ongoing research to improve the speed of QSTS simulation has revealed many unique aspects of distribution system modelling and sequential power flow analysis that make fast QSTS a very difficult problem to solve. In this report , the most relevant challenges in reducing the computational time of QSTS simulations are presented: number of power flows to solve, circuit complexity, time dependence between time steps, multiple valid power flow solutions, controllable element interactions, and extensive accurate simulation analysis.

  8. Challenges and innovative technologies on fuel handling systems for future sodium-cooled fast reactors

    International Nuclear Information System (INIS)

    Chassignet, Mathieu; Dumas, Sebastien; Penigot, Christophe; Prele, Gerard; Capitaine, Alain; Rodriguez, Gilles; Sanseigne, Emmanuel; Beauchamp, Francois

    2011-01-01

    The reactor refuelling system provides the means of transporting, storing, and handling reactor core subassemblies. The system consists of the facilities and equipment needed to accomplish the scheduled refuelling operations. The choice of a FHS impacts directly on the general design of the reactor vessel (primary vessel, storage, and final cooling before going to reprocessing), its construction cost, and its availability factor. Fuel handling design must take into account various items and in particular operating strategies such as core design and management and core configuration. Moreover, the FHS will have to cope with safety assessments: a permanent cooling strategy to prevent fuel clad rupture, plus provisions to handle short-cooled fuel and criteria to ensure safety during handling. In addition, the handling and elimination of residual sodium must be investigated; it implies specific cleaning treatment to prevent chemical risks such as corrosion or excess hydrogen production. The objective of this study is to identify the challenges of a SFR fuel handling system. It will then present the range of technical options incorporating innovative technologies under development to answer the GENERATION IV SFR requirements. (author)

  9. Challenges in Wireless System Integration as Enablers for Indoor Context Aware Environments

    Directory of Open Access Journals (Sweden)

    Peio López-Iturri

    2017-07-01

    Full Text Available The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes. In this context, inherent transceiver density poses challenges in overall system operation, given by multiple node operation which increases overall interference levels. In this work, a deterministic based analysis applied to variable density wireless sensor network operation within complex indoor scenarios is presented, as a function of topological node distribution. The extensive analysis derives interference characterizations, both for conventional transceivers as well as wearables, which provide relevant information in terms of individual node configuration as well as complete network layout.

  10. PUCK: An Automated Prompting System for Smart Environments: Towards achieving automated prompting; Challenges involved.

    Science.gov (United States)

    Das, Barnan; Cook, Diane J; Schmitter-Edgecombe, Maureen; Seelye, Adriana M

    2012-10-01

    The growth in popularity of smart environments has been quite steep in the last decade and so has the demand for smart health assistance systems. A smart home-based prompting system can enhance these technologies to deliver in-home interventions to users for timely reminders or brief instructions describing the way a task should be done for successful completion. This technology is in high demand given the desire of people who have physical or cognitive limitations to live independently in their homes. In this paper, with the introduction of the "PUCK" prompting system, we take an approach to automate prompting-based interventions without any predefined rule sets or user feedback. Unlike other approaches, we use simple off-the-shelf sensors and learn the timing for prompts based on real data that is collected with volunteer participants in our smart home test bed. The data mining approaches taken to solve this problem come with the challenge of an imbalanced class distribution that occurs naturally in the data. We propose a variant of an existing sampling technique, SMOTE, to deal with the class imbalance problem. To validate the approach, a comparative analysis with Cost Sensitive Learning is performed.

  11. Challenges and models in supporting logistics system design for dedicated-biomass-based bioenergy industry.

    Science.gov (United States)

    Zhu, Xiaoyan; Li, Xueping; Yao, Qingzhu; Chen, Yuerong

    2011-01-01

    This paper analyzed the uniqueness and challenges in designing the logistics system for dedicated biomass-to-bioenergy industry, which differs from the other industries, due to the unique features of dedicated biomass (e.g., switchgrass) including its low bulk density, restrictions on harvesting season and frequency, content variation with time and circumambient conditions, weather effects, scattered distribution over a wide geographical area, and so on. To design it, this paper proposed a mixed integer linear programming model. It covered from planting and harvesting switchgrass to delivering to a biorefinery and included the residue handling, concentrating on integrating strategic decisions on the supply chain design and tactical decisions on the annual operation schedules. The present numerical examples verified the model and demonstrated its use in practice. This paper showed that the operations of the logistics system were significantly different for harvesting and non-harvesting seasons, and that under the well-designed biomass logistics system, the mass production with a steady and sufficient supply of biomass can increase the unit profit of bioenergy. The analytical model and practical methodology proposed in this paper will help realize the commercial production in biomass-to-bioenergy industry. Copyright © 2010 Elsevier Ltd. All rights reserved.

  12. Challenges in small screening laboratories: implementing an on-demand laboratory information management system.

    Science.gov (United States)

    Lemmon, Vance P; Jia, Yuanyuan; Shi, Yan; Holbrook, S Douglas; Bixby, John L; Buchser, William

    2011-11-01

    The Miami Project to Cure Paralysis, part of the University of Miami Miller School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) of neurons. The goal of the laboratory is to uncover signaling pathways, genes, compounds, or drugs that can be used to promote nerve growth. HCA permits the quantification of neuronal morphology, including the lengths and numbers of axons. HCA of various libraries on primary neurons requires a team-based approach, a variety of process steps and complex manipulations of cells and libraries to obtain meaningful results. HCA itself produces vast amounts of information including images, well-based data and cell-based phenotypic measures. Documenting and integrating the experimental workflows, library data and extensive experimental results is challenging. For academic laboratories generating large data sets from experiments involving thousands of perturbagens, a Laboratory Information Management System (LIMS) is the data tracking solution of choice. With both productivity and efficiency as driving rationales, the Miami Project has equipped its HCA laboratory with an On Demand or Software As A Service (SaaS) LIMS to ensure the quality of its experiments and workflows. The article discusses how the system was selected and integrated into the laboratory. The advantages of a SaaS based LIMS over a client-server based system are described. © 2011 Bentham Science Publishers

  13. Defining the methodological challenges and opportunities for an effective science of sociotechnical systems and safety

    Science.gov (United States)

    Waterson, Patrick; Robertson, Michelle M.; Cooke, Nancy J.; Militello, Laura; Roth, Emilie; Stanton, Neville A.

    2015-01-01

    An important part of the application of sociotechnical systems theory (STS) is the development of methods, tools and techniques to assess human factors and ergonomics workplace requirements. We focus in this paper on describing and evaluating current STS methods for workplace safety, as well as outlining a set of six case studies covering the application of these methods to a range of safety contexts. We also describe an evaluation of the methods in terms of ratings of their ability to address a set of theoretical and practical questions (e.g. the degree to which methods capture static/dynamic aspects of tasks and interactions between system levels). The outcomes from the evaluation highlight a set of gaps relating to the coverage and applicability of current methods for STS and safety (e.g. coverage of external influences on system functioning; method usability). The final sections of the paper describe a set of future challenges, as well as some practical suggestions for tackling these. Practitioner Summary: We provide an up-to-date review of STS methods, a set of case studies illustrating their use and an evaluation of their strengths and weaknesses. The paper concludes with a ‘roadmap’ for future work. PMID:25832121

  14. Reawakening the Irish language through the ırish education system: Challenges and priorities

    Directory of Open Access Journals (Sweden)

    T.J. Ó Ceallaigh

    2015-12-01

    Full Text Available As a language, Irish is unique to Ireland and is, therefore, of crucial importance to the identity of the Irish people, to Irish culture and to world heritage. The Irish language however has had a turbulent and traumatic history and has endured a complex and varied relationship with the Irish people. Since the foundation of the Irish Free State, the education system has been targeted as an agency and model for Irish language planning, education and language revitalisation and has had a critical role in generating linguistic ability in the Irish language. This paper reviews the complex and controversial relationship between the Irish language, the State and the education system from an historical perspective. Some key acts of recent legislation and government initiatives, which impact on the status of the Irish language are considered and barriers and challenges to progress in the education system are outlined. The paper concludes with a discussion on significant positive factors which may revolutionise and reawaken the Irish language through our education syste

  15. Challenges in Albania for improving Labor Market Information System and Labor Market Governance

    Directory of Open Access Journals (Sweden)

    Neshat Zeneli

    2017-07-01

    Full Text Available Labour Market Policy of the Republic of Albania in terms of design (preparation, case identification, formulation, and approval, programming and budgeting, implementation, monitoring and evaluation has a short experience (1995-ongoing. The influence and presence of hierarchy model is very high beside the support of different programs and projects through bilateral and EU programs. Still there are a lot of key issues to be addressed. The most important issues to be addressed in this paper are evidence based related to: • The Availability of Labor Market Information and its structure on national, regional and local level in Albania and how much this information is used for -policy making and –monitoring/evaluation in terms of input, output, outcome and impact. • Mode of the governance of the labor market in Albania and challenges to pass from the hierarchy to market and network governance. The main aim of this paper/article is to do a complete and deep analysis of the actual situation of labor market information system and labor market governance in Albania, and to propose conclusions and recommendations that will improve both labor market information system and the labor market governance from hierarchy to market and network governance, because good and standardized labor information system can help towards right policy decisions and good governance of LM policy means more employment, more stability, more social inclusion in the society.

  16. A Grand Challenge for CMOS Scaling: Alternate Gate Dielectrics

    Science.gov (United States)

    Wallace, Robert M.

    2001-03-01

    Many materials systems are currently under consideration as potential replacements for SiO2 as the gate dielectric material for sub-0.13 um complementary metal oxide semiconductor (CMOS) technology. The prospect of replacing SiO2 is a formidable task because the alternate gate dielectric must provide many properties that are, at a minimum, comparable to those of SiO2 yet with a much higher permittivity. A systematic examination of the required performance of gate dielectrics suggests that the key properties to consider in the selection an alternative gate dielectric candidate are (a) permittivity, band gap and band alignment to silicon, (b) thermodynamic stability, (c) film morphology, (d) interface quality, (e) compatibility with the current or expected materials to be used in processing for CMOS devices, (f) process compatibility, and (g) reliability. Many dielectrics appear favorable in some of these areas, but very few materials are promising with respect to all of these guidelines. We will review the performance requirements for materials associated with CMOS scaling, the challenges associated with these requirements, and the state-of-the-art in current research for alternate gate dielectrics. The requirements for process integration compatibility are remarkably demanding, and any serious candidates will emerge only through continued, intensive investigation.

  17. Cultured meat from stem cells: challenges and prospects.

    Science.gov (United States)

    Post, Mark J

    2012-11-01

    As one of the alternatives for livestock meat production, in vitro culturing of meat is currently studied. The generation of bio-artificial muscles from satellite cells has been ongoing for about 15 years, but has never been used for generation of meat, while it already is a great source of animal protein. In order to serve as a credible alternative to livestock meat, lab or factory grown meat should be efficiently produced and should mimic meat in all of its physical sensations, such as visual appearance, smell, texture and of course, taste. This is a formidable challenge even though all the technologies to create skeletal muscle and fat tissue have been developed and tested. The efficient culture of meat will primarily depend on culture conditions such as the source of medium and its composition. Protein synthesis by cultured skeletal muscle cells should further be maximized by finding the optimal combination of biochemical and physical conditions for the cells. Many of these variables are known, but their interactions are numerous and need to be mapped. This involves a systematic, if not systems, approach. Given the urgency of the problems that the meat industry is facing, this endeavor is worth undertaking. As an additional benefit, culturing meat may provide opportunities for production of novel and healthier products. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Open source challenges for hospital information system (HIS in developing countries: a pilot project in Mali

    Directory of Open Access Journals (Sweden)

    Chaacho Saad

    2010-04-01

    Full Text Available Abstract Background We are currently witnessing a significant increase in use of Open Source tools in the field of health. Our study aims to research the potential of these software packages for developing countries. Our experiment was conducted at the Centre Hospitalier Mere Enfant in Mali. Methods After reviewing several Open Source tools in the field of hospital information systems, Mediboard software was chosen for our study. To ensure the completeness of Mediboard in relation to the functionality required for a hospital information system, its features were compared to those of a well-defined comprehensive record management tool set up at the University Hospital "La Timone" of Marseilles in France. It was then installed on two Linux servers: a first server for testing and validation of different modules, and a second one for the deployed full implementation. After several months of use, we have evaluated the usability aspects of the system including feedback from end-users through a questionnaire. Results Initial results showed the potential of Open Source in the field of health IT for developing countries like Mali. Five main modules have been fully implemented: patient administrative and medical records management of hospital activities, tracking of practitioners' activities, infrastructure management and the billing system. This last component of the system has been fully developed by the local Mali team. The evaluation showed that the system is broadly accepted by all the users who participated in the study. 77% of the participants found the system useful; 85% found it easy; 100% of them believe the system increases the reliability of data. The same proportion encourages the continuation of the experiment and its expansion throughout the hospital. Conclusions In light of the results, we can conclude that the objective of our study was reached. However, it is important to take into account the recommendations and the challenges discussed

  19. Universal coverage challenges require health system approaches; the case of India.

    Science.gov (United States)

    Duran, Antonio; Kutzin, Joseph; Menabde, Nata

    2014-02-01

    This paper uses the case of India to demonstrate that Universal Health Coverage (UHC) is about not only health financing; personal and population services production issues, stewardship of the health system and generation of the necessary resources and inputs need to accompany the health financing proposals. In order to help policy makers address UHC in India and sort out implementation issues, the framework developed by the World Health Organization (WHO) in the World Health Report 2000 and its subsequent extensions are advocated. The framework includes final goals, generic intermediate objectives and four inter-dependent functions which interact as a system; it can be useful by diagnosing current shortcomings and facilitating the filling up of gaps between functions and goals. Different positions are being defended in India re the preconditions for UHC to succeed. This paper argues that more (public) money will be important, but not enough; it needs to be supplemented with broad interventions at various health system levels. The paper analyzes some of the most important issues in relation to the functions of service production, generation of inputs and the necessary stewardship. It also pays attention to reform implementation, as different from its design, and suggests critical aspects emanating from a review of recent health system reforms. Precisely because of the lack of comparative reference for India, emphasis is made on the need to accompany implementation with analysis, so that the "solutions" ("what to do?", "how to do it?") are found through policy analysis and research embedded into flexible implementation. Strengthening "evidence-to-policy" links and the intelligence dimension of stewardship/leadership as well as accountability during implementation are considered paramount. Countries facing similar challenges to those faced by India can also benefit from the above approaches. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  20. Evolving the Nation's Energy Infrastructure: A Challenging System Issue for the Twenty-First Century; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, B.

    2007-04-01

    Over the next several decades, a profound transformation of the global energy enterprise will occur driven largely by population growth and economic development. How this growing demand for energy is met poses one of the most complex and challenging issues of our time. The current national energy dialogue reflects the challenge in simultaneously considering the social, political, economic, and technical issues as the energy system is defined, technical targets are established, and programs and investments are implemented to meet those technical targets. This paper examines the general concepts and options for meeting this challenge.

  1. Costs and epidemiological changes of chronic diseases: implications and challenges for health systems.

    Directory of Open Access Journals (Sweden)

    Armando Arredondo

    Full Text Available The need to integrate economic and epidemiological aspects in the clinical perspective leads to a proposal for the analysis of health disparities and to an evaluation of the health services and of the new challenges which are now being faced by health system reforms in middle income countries.To identify the epidemiological changes, the demand for health services and economic burden from chronic diseases (diabetes and hypertension in a middle income county.We conducted longitudinal analyses of costs and epidemiological changes for diabetes and hypertension in the Mexican health system. The study population included both the insured and uninsured populations. The cost-evaluation method was used, based on the instrumentation and consensus techniques. To estimate the epidemiological changes and financial consequences for 2014-2016, six models were constructed according to the Box-Jenkins technique, using confidence intervals of 95%, and the Box-Pierce test.Regarding epidemiological changes expected in both diseases for 2014 vs. 2016, an increase is expected, although results predict a greater increase for diabetes, 8-12% in all three studied institutions, (p < .05. Indeed, in the case of diabetes, the increase was 41469 cases for uninsured population (SSA and 65737 for the insured population (IMSS and ISSSTE. On hypertension cases the increase was 38109 for uninsured vs 62895 for insured. Costs in US$ ranged from $699 to $748 for annual case management per patient in the case of diabetes, and from $485 to $622 in patients with hypertension. Comparing financial consequences of health services required by insured and uninsured populations, the greater increase (23% will be for the insured population (p < .05. The financial requirements of both diseases will amount to 19.5% of the total budget for the uninsured and 12.5% for the insured population.If the risk factors and the different health care models remain as they currently are, the economic

  2. Design challenges in nanoparticle-based platforms: Implications for targeted drug delivery systems

    Science.gov (United States)

    Mullen, Douglas Gurnett

    Characterization and control of heterogeneous distributions of nanoparticle-ligand components are major design challenges for nanoparticle-based platforms. This dissertation begins with an examination of poly(amidoamine) (PAMAM) dendrimer-based targeted delivery platform. A folic acid targeted modular platform was developed to target human epithelial cancer cells. Although active targeting was observed in vitro, active targeting was not found in vivo using a mouse tumor model. A major flaw of this platform design was that it did not provide for characterization or control of the component distribution. Motivated by the problems experienced with the modular design, the actual composition of nanoparticle-ligand distributions were examined using a model dendrimer-ligand system. High Pressure Liquid Chromatography (HPLC) resolved the distribution of components in samples with mean ligand/dendrimer ratios ranging from 0.4 to 13. A peak fitting analysis enabled the quantification of the component distribution. Quantified distributions were found to be significantly more heterogeneous than commonly expected and standard analytical parameters, namely the mean ligand/nanoparticle ratio, failed to adequately represent the component heterogeneity. The distribution of components was also found to be sensitive to particle modifications that preceded the ligand conjugation. With the knowledge gained from this detailed distribution analysis, a new platform design was developed to provide a system with dramatically improved control over the number of components and with improved batch reproducibility. Using semi-preparative HPLC, individual dendrimer-ligand components were isolated. The isolated dendrimer with precise numbers of ligands were characterized by NMR and analytical HPLC. In total, nine different dendrimer-ligand components were obtained with degrees of purity ≥80%. This system has the potential to serve as a platform to which a precise number of functional molecules

  3. Intelligent systems for urban search and rescue: challenges and lessons learned

    Science.gov (United States)

    Jacoff, Adam; Messina, Elena; Weiss, Brian A.

    2003-09-01

    Urban search and rescue (USAR) is one of the most dangerous and time-critical non-wartime activities. Researchers have been developing hardware and software to enable robots to perform some search and rescue functions so as to minimize the exposure of human rescue personnel to danger and maximize the survival of victims. Significant progress has been achieved, but much work remains. USAR demands a blending of numerous specialized technologies. An effective USAR robot must be endowed with key competencies, such as being able to negotiate collapsed structures, find victims and assess their condition, identify potential hazards, generate maps of the structure and victim locations, and communicate with rescue personnel. These competencies bring to bear work in numerous sub-disciplines of intelligent systems (or artificial intelligence) such as sensory processing, world modeling, behavior generation, path planning, and human-robot interaction, in addition to work in communications, mechanism design and advanced sensors. In an attempt to stimulate progress in the field, reference USAR challenges are being developed and propagated worldwide. In order to make efficient use of finite research resources, the robotic USAR community must share a common understanding of what is required, technologically, to attain each competency, and have a rigorous measure of the current level of effectiveness of various technologies. NIST is working with partner organizations to measure the performance of robotic USAR competencies and technologies. In this paper, we describe the reference test arenas for USAR robots, assess the current challenges within the field, and discuss experiences thus far in the testing effort.

  4. Challenges of Executive Information Systems in listed Johannesburg Stock Exchange companies

    Directory of Open Access Journals (Sweden)

    Elmarie Papageorgiou

    2011-09-01

    Objectives: The purpose of this study is to establish and to determine the existence, and to what extent EISs exist in all levels of management and to identify the challenges companies experienced in listed JSE companies. Therefore the problem exists that EIS-users at all levels of management are unaware of the challenges of EISs and that EISs can be used as a tool to analyse their businesses’ performance and competitiveness. Method: A mixed method was used; both quantitative and qualitative in nature. Questionnaires were sent to 334 listed JSE companies and 13 interviews were conducted with users of EISs in all levels of management. Results: The results of the study demonstrate that the majority of respondents of the questionnaire have an EIS or plan to implement an EIS. The results further revealed the respondents’ positive attitude towards EISs as it is an excellent management information tool that adds strategic value to their business, that is critical for real-time decision-making, solves problems and creates a competitive edge. From the results it is evident that there is a need for an EIS to be ‘everybody’s information system’. The results of the interviews demonstrate that an EIS is a seamless reliable system necessary for proper timeous decision-making. The respondents to the questionnaire and the interviewees indicated that they understood the value of EISs as a useful part of their company. Conclusion: The study adds value to the awareness and understanding of EISs that creates a business environment in which business and management can enhance sustainability and strategic competitiveness.

  5. BRIC Health Systems and Big Pharma: A Challenge for Health Policy and Management.

    Science.gov (United States)

    Rodwin, Victor G; Fabre, Guilhem; Ayoub, Rafael F

    2018-01-02

    BRIC nations - Brazil, Russia, India, and China - represent 40% of the world's population, including a growing aging population and middle class with an increasing prevalence of chronic disease. Their healthcare systems increasingly rely on prescription drugs, but they differ from most other healthcare systems because healthcare expenditures in BRIC nations have exhibited the highest revenue growth rates for pharmaceutical multinational corporations (MNCs), Big Pharma. The response of BRIC nations to Big Pharma presents contrasting cases of how governments manage the tensions posed by rising public expectations and limited resources to satisfy them. Understanding these tensions represents an emerging area of research and an important challenge for all those who work in the field of health policy and management (HPAM). © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  6. A Concise Presentation of Doubly Fed Induction Generator Wind Energy Conversion Systems Challenges and Solutions

    Directory of Open Access Journals (Sweden)

    Julius Mwaniki

    2017-01-01

    Full Text Available There is increased worldwide wind power generation, a large percentage of which is grid connected. The doubly fed induction generator (DFIG wind energy conversion system (WECS has many merits and, as a result, large numbers have been installed to date. The DFIG WECS operation, under both steady state and fault conditions, is of great interest since it impacts on grid performance. This review paper presents a condensed look at the various applied solutions to the challenges of the DFIG WECS including maximum power point tracking, common mode voltages, subsynchronous resonance, losses, modulation, power quality, and faults both internal and from the grid. It also looks at approaches used to meet the increasingly stringent grid codes requirements for the DFIG WECS to not only ride through faults but also provide voltage support. These are aspects of the DFIG WECS that are critical for system operators and prospective investors and can also serve as an introduction for new entrants into this area of study.

  7. Opportunities and challenges of Web 2.0 within the health care systems: an empirical exploration.

    Science.gov (United States)

    Lupiáñez-Villanueva, Francisco; Mayer, Miquel Angel; Torrent, Joan

    2009-09-01

    The Internet has become one of the main drivers of e-health. Whilst its impact and potential is being analysed, the Web 2.0 phenomenon has reached the health field and has emerged as a buzzword that people use to describe a wide range of online activities and applications. The aims of this article are: to explore the opportunities and challenges of the Web 2.0 within the health care system and to identify the gap between the potential of these online activities and applications and the empirical data. The analysis is based on: online surveys to physicians, nurses, pharmacist and patient support groups; static web shot analysis of 1240 web pages and exploration of the most popular Web 2.0 initiatives. The empirical results contrast with the Web 2.0 trends identified. Whereas the main characteristic of the Web 2.0 is the opportunity for social interaction, the health care system at large could currently be characterised by: a lack of interactive communication technologies available on the Internet; a lack of professional production of health care information on the Internet, and a lack of interaction between these professionals and patients on the Internet. These results reveal a scenario away from 2.0 trends.

  8. Health Information System Role-Based Access Control Current Security Trends and Challenges.

    Science.gov (United States)

    de Carvalho Junior, Marcelo Antonio; Bandiera-Paiva, Paulo

    2018-01-01

    This article objective is to highlight implementation characteristics, concerns, or limitations over role-based access control (RBAC) use on health information system (HIS) using industry-focused literature review of current publishing for that purpose. Based on the findings, assessment for indication of RBAC is obsolete considering HIS authorization control needs. We have selected articles related to our investigation theme "RBAC trends and limitations" in 4 different sources related to health informatics or to the engineering technical field. To do so, we have applied the following search query string: "Role-Based Access Control" OR "RBAC" AND "Health information System" OR "EHR" AND "Trends" OR "Challenges" OR "Security" OR "Authorization" OR "Attacks" OR "Permission Assignment" OR "Permission Relation" OR "Permission Mapping" OR "Constraint". We followed PRISMA applicable flow and general methodology used on software engineering for systematic review. 20 articles were selected after applying inclusion and exclusion criteria resulting contributions from 10 different countries. 17 articles advocate RBAC adaptations. The main security trends and limitations mapped were related to emergency access, grant delegation, and interdomain access control. Several publishing proposed RBAC adaptations and enhancements in order to cope current HIS use characteristics. Most of the existent RBAC studies are not related to health informatics industry though. There is no clear indication of RBAC obsolescence for HIS use.

  9. An exploration of neuromorphic systems and related design issues/challenges in dark silicon era

    Science.gov (United States)

    Chandaliya, Mudit; Chaturvedi, Nitin; Gurunarayanan, S.

    2018-03-01

    The current microprocessors has shown a remarkable performance and memory capacity improvement since its innovation. However, due to power and thermal limitations, only a fraction of cores can operate at full frequency at any instant of time irrespective of the advantages of new technology generation. This phenomenon of under-utilization of microprocessor is called as dark silicon which leads to distraction in innovative computing. To overcome the limitation of utilization wall, IBM technologies explored and invented neurosynaptic system chips. It has opened a wide scope of research in the field of innovative computing, technology, material sciences, machine learning etc. In this paper, we first reviewed the diverse stages of research that have been influential in the innovation of neurosynaptic architectures. These, architectures focuses on the development of brain-like framework which is efficient enough to execute a broad set of computations in real time while maintaining ultra-low power consumption as well as area considerations in mind. We also reveal the inadvertent challenges and the opportunities of designing neuromorphic systems as presented by the existing technologies in the dark silicon era, which constitute the utmost area of research in future.

  10. Learning in the cloud: a new challenge for a global teaching system in optics and photonics

    Science.gov (United States)

    Sultana, Razia; Christ, Andreas; Feisst, Markus; Curticapean, Dan

    2014-07-01

    Nowadays, it is assumed of many applications, companies and parts of the society to be always available online. However, according to [Times, Oct, 31 2011], 73% of the world population do not use the internet and thus aren't "online" at all. The most common reasons for not being "online" are expensive personal computer equipment and high costs for data connections, especially in developing countries that comprise most of the world's population (e.g. parts of Africa, Asia, Central and South America). However it seems that these countries are leap-frogging the "PC and landline" age and moving directly to the "mobile" age. Decreasing prices for smart phones with internet connectivity and PC-like operating systems make it more affordable for these parts of the world population to join the "always-online" community. Storing learning content in a way accessible to everyone, including mobile and smart phones, seems therefore to be beneficial. This way, learning content can be accessed by personal computers as well as by mobile and smart phones and thus be accessible for a big range of devices and users. A new trend in the Internet technologies is to go to "the cloud". This paper discusses the changes, challenges and risks of storing learning content in the "cloud". The experiences were gathered during the evaluation of the necessary changes in order to make our solutions and systems "cloud-ready".

  11. Health systems' responses to 25 years of HIV in Europe: inequities persist and challenges remain.

    Science.gov (United States)

    Atun, Rifat A; McKee, Martin; Coker, Richard; Gurol-Urganci, Ipek

    2008-05-01

    Europe is currently experiencing the fastest rate of growth of HIV of any region of the world. An analysis of policy and health system responses to the HIV epidemic in Europe and central Asia (hereafter referred to as Europe) over the last 25 years reveals considerable heterogeneity. In general, while noting hazards of broad generalisations and the differences that exist across countries in a particular grouping, effective policies to control HIV have been implemented more widely in western than in central and eastern Europe. However, the evidence suggests persistence of inequalities in access to preventive and treatment services, with those at highest risk, such as commercial sex workers, prisoners, intravenous drug users, and migrants often particularly disadvantaged, despite many targeted programmes. Responses in individual countries, especially in the early stages of the epidemic, were influenced by specific cultural and political factors. Strong leadership and active involvement by civil society organisations emerge as important factors for success but also a limiting factor to the response observed in eastern Europe, where civil society or NGO culture is weak as compared to western Europe. Scaling up of effective responses in many countries in eastern Europe will be challenging-where increased financial resources will have to be accompanied by broader changes to health system organization with greater involvement of the civil society in planning and delivery of client-focused services.

  12. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2012-12-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system.Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies.Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field.Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis.Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models.Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes. The

  13. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2013-02-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system. Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies. Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field. Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis. Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models. Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes

  14. bb̅ud̅ four-quark systems in the Born-Oppenheimer approximation: prospects and challenges

    Science.gov (United States)

    Peters, Antje; Bicudo, Pedro; Wagner, Marc

    2018-03-01

    We summarize previous work on b̅b̅ud four-quark systems in the Born-Oppenheimer approximation and discuss first steps towards an extension to the theoretically more challenging bb̅ud̅ system. Strategies to identify a possibly existing bb̅ud̅ bound state are discussed and first numerical results are presented.

  15. ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale

    DEFF Research Database (Denmark)

    Halling-Brown, M.; Pappalardo, F.; Rapin, Nicolas

    2010-01-01

    , such as the European Virtual Physiological Human initiative. Finally, we ask a key question: How long will it take us to resolve these challenges and when can we expect to have fully functional models that will deliver health-care benefits in the form of personalized care solutions and improved disease prevention?......The ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model of the human immune system-that is, one that reflects both the diversity and the relative proportions of the molecules and cells that comprise it-together with the grid infrastructure necessary to apply...... this model to specific applications in the field of immunology. These objectives present the ImmunoGrid Consortium with formidable challenges in terms of complexity of the immune system, our partial understanding about how the immune system works, the lack of reliable data and the scale of computational...

  16. International Safety Management – Safety Management Systems and the Challenges of Changing a Culture

    Directory of Open Access Journals (Sweden)

    Gregory Hanchrow

    2017-03-01

    Full Text Available Over the past generation, the ISM code has brought forth tremendous opportunities to investigate and enhance the human factor in shipping through the implementation of Safety Management Systems. One of the critical factors to this implementation has been mandatory compliance and a requirement for obtaining a Document of Compliance (DOC for vessels operating globally or at least internationally. A primary objective of these systems is to maintain them as “living” or “dynamic” systems that are always evolving. As the ISM code has evolved, there have been instances where large organizations have opted to maintain a voluntary DOC from their respective class society. This has been accomplished with a large human factor element as typically an organizational culture does not always accept change readily especially if there is not a legal requirement to do so. In other words, when considering maritime training is it possible that organizations may represent cultural challenges? The intent of this paper will be to research large maritime operations that have opted for a document of compliance voluntarily and compare them to similar organizations that have been mandated by international law to do the same. The result should be to gain insight into the human factors that must contribute to a culture change in the organization for the purposes of a legal requirement versus the human factors that contribute to a voluntary establishment of a safety management system. This analysis will include both the executive decision making that designs a system implementation and the operational sector that must execute its implementation. All success and failures of education and training can be determined by the outcome. Did the training achieve its goal? Or has the education prepared the students to embrace a new idea in conjunction with a company goal or a new regulatory scheme? In qualifying the goal of a successful ISM integration by examining both

  17. Challenges of nuclear fusion

    International Nuclear Information System (INIS)

    Kunkel, W.B.

    1987-01-01

    After 30 years of research and development in many countries, the magnetic confinement fusion experiments finally seem to be getting close to the original first goal: the point of ''scientific break-even''. Plans are being made for a generation of experiments and tests with actual controlled thermonuclear fusion conditions. Therefore engineers and material scientists are hard at work to develop the required technology. In this paper the principal elements of a generic fusion reactor are described briefly to introduce the reader to the nature of the problems at hand. The main portion of the presentation summarises the recent advances made in this field and discusses the major issues that still need to be addressed in regard to materials and technology for fusion power. Specific examples are the problems of the first wall and other components that come into direct contact with the plasma, where both lifetime and plasma contamination are matters of concern. Equally challenging are the demands on structural materials and on the magnetic-field coils, particularly in connection with the neutron-radiation environment of fusion reactors. Finally, the role of ceramics must be considered, both for insulators and for fuel breeding purposes. It is evident that we still have a formidable task before us, but at this point none of the problems seem to be insoluble. (author)

  18. A Critical Appraisal of the Juvenile Justice System under Cameroon's 2005 Criminal Procedure Code: Emerging Challenges

    Directory of Open Access Journals (Sweden)

    S Tabe

    2012-03-01

    Full Text Available The objective of this article is to examine the changes introduced by the 2005 Cameroonian Criminal Procedure Code on matters of juvenile justice, considering that before this Code, juvenile justice in Cameroon was governed by extra-national laws. In undertaking this analysis, the article highlights the evolution of the administration of juvenile justice 50 years after independence of Cameroon. It also points out the various difficulties and shortcomings in the treatment of juvenile offenders in Cameroon since the enactment of the new Criminal Procedure Code. The article reveals that the 2005 Code is an amalgamation of all hitherto existing laws in the country that pertained to juvenile justice, and that despite the considerable amount of criticism it has received, the Code is clearly an improvement of the system of juvenile justice in Cameroon, since it represents a balance of the due process rights of young people, the protection of society and the special needs of young offenders. This is so because the drafters of the Code took a broad view of the old laws on juvenile justice. Also a wide range of groups were consulted, including criminal justice professionals, children’s service organisations, victims, parents, young offenders, educators, advocacy groups and social-policy analysts. However, to address the challenges that beset the juvenile justice system of Cameroon, the strategy of the government should be focussed on three areas: the prevention of youth crime, the provision of meaningful consequences for the actions of young people, and the rehabilitation and reintegration of young offenders. Cameroonian law should seek educative solutions rather than to impose prison sentences or other repressive measures on young offenders. Special courts to deal with young offenders should be established outside the regular penal system and should be provided with resources that are adequate for and appropriate to fostering their understanding of

  19. Models meet data: Challenges and opportunities in implementing land management in Earth system models.

    Science.gov (United States)

    Pongratz, Julia; Dolman, Han; Don, Axel; Erb, Karl-Heinz; Fuchs, Richard; Herold, Martin; Jones, Chris; Kuemmerle, Tobias; Luyssaert, Sebastiaan; Meyfroidt, Patrick; Naudts, Kim

    2018-04-01

    As the applications of Earth system models (ESMs) move from general climate projections toward questions of mitigation and adaptation, the inclusion of land management practices in these models becomes crucial. We carried out a survey among modeling groups to show an evolution from models able only to deal with land-cover change to more sophisticated approaches that allow also for the partial integration of land management changes. For the longer term a comprehensive land management representation can be anticipated for all major models. To guide the prioritization of implementation, we evaluate ten land management practices-forestry harvest, tree species selection, grazing and mowing harvest, crop harvest, crop species selection, irrigation, wetland drainage, fertilization, tillage, and fire-for (1) their importance on the Earth system, (2) the possibility of implementing them in state-of-the-art ESMs, and (3) availability of required input data. Matching these criteria, we identify "low-hanging fruits" for the inclusion in ESMs, such as basic implementations of crop and forestry harvest and fertilization. We also identify research requirements for specific communities to address the remaining land management practices. Data availability severely hampers modeling the most extensive land management practice, grazing and mowing harvest, and is a limiting factor for a comprehensive implementation of most other practices. Inadequate process understanding hampers even a basic assessment of crop species selection and tillage effects. The need for multiple advanced model structures will be the challenge for a comprehensive implementation of most practices but considerable synergy can be gained using the same structures for different practices. A continuous and closer collaboration of the modeling, Earth observation, and land system science communities is thus required to achieve the inclusion of land management in ESMs. © 2017 John Wiley & Sons Ltd.

  20. Technical Challenge and Demonstration of Advanced Solution Monitoring and Measurement System (ASMS)

    International Nuclear Information System (INIS)

    Takaya, A.; Mukai, Y.; Nakamura, H.; Hosoma, T.; Yoshimoto, K.; Tamura, T.; Iwamoto, T.

    2010-01-01

    JNFL and JAEA have collaboratively started to develop an Advanced Solution Measurement and monitoring System (ASMS) as a part of technical challenge intended for next generation safeguards NDA equipment. After we completed feasibility study by using small detectors, the second stage of ASMS has installed into PCDF tank located in a cell, and then tested and calibrated by Pu nitrate solution experimentally. There was no experience measuring around 50kg Pu inventory directly, so it was very challenging work. The conventional SMMS (Solution Monitoring and Measurement System) that is composed of precision manometers acquires density, level and temperature of solution, so that the sampling and analysis are essential to obtain the nuclear material amount in the tank. The SMMS has two weak points on verification and monitoring of the nuclear material flow and inventory; (1) Direct measurement of the inventory cannot be done, (2) Solution rework and reagent adjustment operation in actual plant will make miss-interpretation on the monitoring evaluation. The purpose of ASMS development is to establish quantitative plutonium mass measurement technique directly by NDA of high concentrated pure plutonium nitrate solution and monitoring capability for solution transfers in a process. The merits of ASMS are considered below; (1) Provide direct Pu measurement and continuous monitoring capability, (2) Eliminate sampling and analysis at IIV, (3) Reduce unmeasured inventory. The target of the measurement uncertainty of ASMS is set less than 6% (1sigma) which is equivalent to meet the detection level of the partial defect at IIV by NDA. Known-alpha coincidence counting technique is applied to the ASMS, which is similar to the NDAs for MOX powder as a principle measurement technique. Especially, three following points are key techniques to establish ASMS. (1) Pre-determination of plutonium isotopic composition because it impacts alpha and rho-zero values to obtain multiplication

  1. Synergies, strengths and challenges: findings on community capability from a systematic health systems research literature review

    Directory of Open Access Journals (Sweden)

    Asha S. George

    2016-11-01

    Full Text Available Abstract Background Community capability is the combined influence of a community’s social systems and collective resources that can address community problems and broaden community opportunities. We frame it as consisting of three domains that together support community empowerment: what communities have; how communities act; and for whom communities act. We sought to further understand these domains through a secondary analysis of a previous systematic review on community participation in health systems interventions in low and middle income countries (LMICs. Methods We searched for journal articles published between 2000 and 2012 related to the concepts of “community”, “capability/participation”, “health systems research” and “LMIC.” We identified 64 with rich accounts of community participation involving service delivery and governance in health systems research for thematic analysis following the three domains framing community capability. Results When considering what communities have, articles reported external linkages as the most frequently gained resource, especially when partnerships resulted in more community power over the intervention. In contrast, financial assets were the least mentioned, despite their importance for sustainability. With how communities act, articles discussed challenges of ensuring inclusive participation and detailed strategies to improve inclusiveness. Very little was reported about strengthening community cohesiveness and collective efficacy despite their importance in community initiatives. When reviewing for whom communities act, the importance of strong local leadership was mentioned frequently, while conflict resolution strategies and skills were rarely discussed. Synergies were found across these elements of community capability, with tangible success in one area leading to positive changes in another. Access to information and opportunities to develop skills were crucial to community

  2. The Challenge of Providing Safe Water with an Intermittently Supplied Piped Water Distribution System

    Science.gov (United States)

    Kumpel, E.; Nelson, K. L.

    2012-12-01

    An increasing number of urban residents in low- and middle-income countries have access to piped water; however, this water is often not available continuously. 84% of reporting utilities in low-income countries provide piped water for fewer than 24 hours per day (van den Berg and Danilenko, 2010), while no major city in India has continuous piped water supply. Intermittent water supply leaves pipes vulnerable to contamination and forces households to store water or rely on alternative unsafe sources, posing a health threat to consumers. In these systems, pipes are empty for long periods of time and experience low or negative pressure even when water is being supplied, leaving them susceptible to intrusion from sewage, soil, or groundwater. Households with a non-continuous supply must collect and store water, presenting more opportunities for recontamination. Upgrading to a continuous water supply, while an obvious solution to these challenges, is currently out of reach for many resource-constrained utilities. Despite its widespread prevalence, there are few data on the mechanisms causing contamination in an intermittent supply and the frequency with which it occurs. Understanding the impact of intermittent operation on water quality can lead to strategies to improve access to safe piped water for the millions of people currently served by these systems. We collected over 100 hours of continuous measurements of pressure and physico-chemical water quality indicators and tested over 1,000 grab samples for indicator bacteria over 14 months throughout the distribution system in Hubli-Dharwad, India. This data set is used to explore and explain the mechanisms influencing water quality when piped water is provided for a few hours every 3-5 days. These data indicate that contamination occurs along the distribution system as water travels from the treatment plant to reservoirs and through intermittently supplied pipes to household storage containers, while real

  3. [The challenge of adequate reimbursement for the seriously injured patient in the German DRG system].

    Science.gov (United States)

    Franz, D; Lefering, R; Siebert, H; Windolf, J; Roeder, N; Mahlke, L

    2013-02-01

    Critically injured patients are a very heterogeneous group, medically and economically. Their treatment is a major challenge for both the medical care and the appropriate financial reimbursement. Systematic underfunding can have a significant impact on the quality of patient care. In 2009 the German Trauma Society and the DRG-Research Group of the University Hospital Muenster initialised a DRG evaluation project to analyse the validity of case allocation of critically injured patients within the German DRG system versions 2008 and 2011 with additional consideration of clinical data from the trauma registry of the German Trauma Society. Severe deficits within the G-DRG structure were identified and specific solutions were designed and realised. A retrospective analysis was undertaken of standardised G-DRG data (§ 21 KHEntgG) including case-related cost data from 3 362 critically injured patients in the periods 2007 and 2008 from 10 university hospitals and 7 large municipal hospitals. For 1 241 cases of the sample, complementary detailed information was available from the trauma registry of the German Trauma Society to monitor the case allocation of critically injured patients within the G-DRG system. Analyses of coding and grouping, performance of case allocation, and the homogeneity of costs in the G-DRG versions 2008 and 2011 were done. The following situations were found: (i) systematic underfunding of trauma patients in the G-DRG-Version 2008, especially trauma patients with acute paraplegia; (ii) participation in the official G-DRG development for 2011 with 13 proposals which were largely realised; (ii) the majority of cases with cost-covering in the G-DRG version 2011; (iv) significant improvements in the quality of statistical criteria; (v) overfunded trauma patients with high intensive care costs; (vi) underfunding for clinically relevant critically injured patients not identified in the G-DRG system. The quality of the G-DRG system is measured by the

  4. Opportunities and challenges for structural health monitoring of radioactive waste systems and structures

    Energy Technology Data Exchange (ETDEWEB)

    Giurgiutiu, Victor [University of South Carolina, Columbia, SC 29208 (United States); Mendez Torres, Adrian E. [Savannah River National Laboratory, Aiken, SC 29808 (United States)

    2013-07-01

    Radioactive waste systems and structures (RWSS) are safety-critical facilities in need of monitoring over prolonged periods of time. Structural health monitoring (SHM) is an emerging technology that aims at monitoring the state of a structure through the use of networks of permanently mounted sensors. SHM technologies have been developed primarily within the aerospace and civil engineering communities. This paper addresses the issue of transitioning the SHM concept to the monitoring of RWSS and evaluates the opportunities and challenges associated with this process. Guided wave SHM technologies utilizing structurally-mounted piezoelectric wafer active sensors (PWAS) have a wide range of applications based on both propagating-wave and standing-wave methodologies. Hence, opportunities exist for transitioning these SHM technologies into RWSS monitoring. However, there exist certain special operational conditions specific to RWSS such as: radiation field, caustic environments, marine environments, and chemical, mechanical and thermal stressors. In order to address the high discharge of used nuclear fuel (UNF) and the limited space in the storage pools the U.S. the Department of Energy (DOE) has adopted a 'Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste' (January 2013). This strategy endorses the key principles that underpin the Blue Ribbon Commission's on America's Nuclear Future recommendations to develop a sustainable program for deploying an integrated system capable of transporting, storing, and disposing of UNF and high-level radioactive waste from civilian nuclear power generation, defense, national security, and other activities. This will require research to develop monitoring, diagnosis, and prognosis tools that can aid to establish a strong technical basis for extended storage and transportation of UNF. Monitoring of such structures is critical for assuring the safety and security of the

  5. Challenges in the implementation of an electronic surveillance system in a resource-limited setting: Alerta, in Peru

    Directory of Open Access Journals (Sweden)

    Soto Giselle

    2008-11-01

    Full Text Available Abstract Background Infectious disease surveillance is a primary public health function in resource-limited settings. In 2003, an electronic disease surveillance system (Alerta was established in the Peruvian Navy with support from the U.S. Naval Medical Research Center Detachment (NMRCD. Many challenges arose during the implementation process, and a variety of solutions were applied. The purpose of this paper is to identify and discuss these issues. Methods This is a retrospective description of the Alerta implementation. After a thoughtful evaluation according to the Centers for Disease Control and Prevention (CDC guidelines, the main challenges to implementation were identified and solutions were devised in the context of a resource-limited setting, Peru. Results After four years of operation, we have identified a number of challenges in implementing and operating this electronic disease surveillance system. These can be divided into the following categories: (1 issues with personnel and stakeholders; (2 issues with resources in a developing setting; (3 issues with processes involved in the collection of data and operation of the system; and (4 issues with organization at the central hub. Some of the challenges are unique to resource-limited settings, but many are applicable for any surveillance system. For each of these challenges, we developed feasible solutions that are discussed. Conclusion There are many challenges to overcome when implementing an electronic disease surveillance system, not only related to technology issues. A comprehensive approach is required for success, including: technical support, personnel management, effective training, and cultural sensitivity in order to assure the effective deployment of an electronic disease surveillance system.

  6. Panoramic view of challenges and opportunities for primary healthcare systems in Pakistan

    International Nuclear Information System (INIS)

    Sharif, H.; Sughra, U.; Butt, Z.

    2016-01-01

    Pakistan has a broad system of primary health care facilities to achieve mission of Health for all. Over the last seven years health expenditure by government of Pakistan has been increased to attain this goal. This study was conducted with the aim to assess all blocks of service readiness (basic equipment, basic amenities, laboratory capacity, standard precautions and essential medicines) in public-primary health care facilities of tehsil Rawalpindi, Pakistan. Methods: A cross-sectional survey was carried out utilizing two separate structured questionnaires for basic health units and rural health centres. Information was collected from administrative heads along with other staff where required, of all public-primary health care facilities of Tehsil Rawalpindi. Data were analysed by using SPSS version17. Results: A total of 26 health facilities were assessed; only 56% BHUs had a sign board that was available in readable form. BHUs with women medical officer as administrative head constituted 52%. Backup for electricity and toilet were the most neglected areas. Basic amenities, standard precautions and laboratory capacity of Basic Health Units (BHUs) showed a clear deviation from standards and is thus a challenge for Pakistan's Primary Health care (PHC). On the other hand for Rural Health Centres (RHCs), most were on the way to meet expectations. Conclusion: Pakistan's government is undoubtedly putting efforts in order to achieve targets of primary healthcare but it needs better mainstreaming of political, institutional and social commitments with modified standards for PHC. (author)

  7. Nuclear technologies to address the challenges in plant-water systems and adaptation strategies

    International Nuclear Information System (INIS)

    Datta, P.S.

    2016-01-01

    In India, over the last decade or so, the stagnation in yield and recent declining trend of the most popular varieties of wheat and rice suggest that the farmers' limited fields with the current soil fertility and agronomic practices has reached the limits of food production sustainability. While water is an important input resource in agriculture, a reliable assessment of its aggregate situation and its protection from depletion and degradation has not received its due respect in the management of agriculture. For enhancement in food production, besides the HYVs and agronomic practices, proper management of the limited groundwater resource, and the water demand under the scarce water availability conditions, enhancing water use efficiency and reducing post-harvest losses is important. Nuclear techniques can provide detailed insight into many long-term process governing Plant-Water Systems, and could be helpful to address the challenges in agriculture. Extensive studies on groundwater assessment and water use efficiency using radioactive "3H, "1"4C, "2"3"4U, "2"3"8U) and stable (2"H, "1"3C, "1"8O) isotopes, have been undertaken for over three decades in Punjab, Haryana, Delhi and Uttar Pradesh of the Gangetic Plains, in Sabarmati River Basin, Gujarat and in arid Rajasthan. Some examples have been discussed, along with HYV development and post harvest preservation using gamma irradiation

  8. Capacities for the Risk Assessment of GMOs: Challenges to Build Sustainable Systems

    Directory of Open Access Journals (Sweden)

    Danilo Fernández Ríos

    2018-04-01

    Full Text Available The need for functional risk assessment bodies in general, and in the biosafety field in particular, demands continued efforts and commitment from regulatory agencies, if results that are sustainable in time are to be achieved. The lack of formal processes that ensure continuity in the application of state of the art scientific criteria, the high rotation in some cases or the lack of experienced professionals, in others, is a challenge to be addressed. Capacity building initiatives with different approaches and degrees of success have been implemented in many countries over the years, supported by diverse governmental and non-governmental organizations. This document summarizes some capacity building experiences in developing countries and concludes that risk assessors taking ownership and regulatory authorities fully committed to developing and retaining highly qualified bodies are a sine qua non to achieve sustainable systems. To this end, it is essential to implement “in-house” continuing education mechanisms supported by external experts and organizations, and inter-institutional cooperation. It has to be noted that these recommendations could only be realized if policy makers understand and appreciate the value of professional, independent regulatory bodies.

  9. Capacities for the Risk Assessment of GMOs: Challenges to Build Sustainable Systems.

    Science.gov (United States)

    Fernández Ríos, Danilo; Rubinstein, Clara; Vicién, Carmen

    2018-01-01

    The need for functional risk assessment bodies in general, and in the biosafety field in particular, demands continued efforts and commitment from regulatory agencies, if results that are sustainable in time are to be achieved. The lack of formal processes that ensure continuity in the application of state of the art scientific criteria, the high rotation in some cases or the lack of experienced professionals, in others, is a challenge to be addressed. Capacity building initiatives with different approaches and degrees of success have been implemented in many countries over the years, supported by diverse governmental and non-governmental organizations. This document summarizes some capacity building experiences in developing countries and concludes that risk assessors taking ownership and regulatory authorities fully committed to developing and retaining highly qualified bodies are a sine qua non to achieve sustainable systems. To this end, it is essential to implement "in-house" continuing education mechanisms supported by external experts and organizations, and inter-institutional cooperation. It has to be noted that these recommendations could only be realized if policy makers understand and appreciate the value of professional, independent regulatory bodies.

  10. Requisites, benefits, and challenges of sustainable HIV/AIDS system-building: where theory meets practice.

    Science.gov (United States)

    Indyk, Debbie; Rier, David A

    2006-01-01

    This paper is the third and final of a series that has previously presented the rationale (Rier and Indyk, this volume) and major program elements (Indyk and Rier, this volume) of an approach to link community and tertiary sociomedical providers, clients/patients, sites, and systems into an integrated response to HIV/AIDS. The primary goal has been to improve sociomedical HIV/AIDS services for a hard-to-reach inner city population. The current paper first summarizes the main advantages (e.g., greater efficiency; more realistic, effective programs with greater credibility among the community; stimulation of knowledge production and dissemination amongst players rarely formally engaged in such activities; creation of a platform useful for other applications) of this work. It then examines some of the main organizational challenges in conducting the work (involving issues such as personnel, coordination, funding, turf conflicts, sustainability). From this discussion emerge organizational requisites to conducting this work (e.g., development of key boundary-spanning figures; attention to the specific interests of potential linkage partners; translation efforts to demonstrate the value of participation; a continuous quality improvement approach featuring wide distribution of feedback in user-friendly form; flexibility, tact and patience), so that others can adapt and apply the linkage approach to manage HIV/AIDS or other problems. Finally, we explain how theory and practice have driven one another in this work.

  11. Development of the Digestive System-Experimental Challenges and Approaches of Infant Lipid Digestion.

    Science.gov (United States)

    Abrahamse, Evan; Minekus, Mans; van Aken, George A; van de Heijning, Bert; Knol, Jan; Bartke, Nana; Oozeer, Raish; van der Beek, Eline M; Ludwig, Thomas

    2012-12-01

    At least during the first 6 months after birth, the nutrition of infants should ideally consist of human milk which provides 40-60 % of energy from lipids. Beyond energy, human milk also delivers lipids with a specific functionality, such as essential fatty acids (FA), phospholipids, and cholesterol. Healthy development, especially of the nervous and digestive systems, depends fundamentally on these. Epidemiological data suggest that human milk provides unique health benefits during early infancy that extend to long-lasting benefits. Preclinical findings show that qualitative changes in dietary lipids, i.e., lipid structure and FA composition, during early life may contribute to the reported long-term effects. Little is known in this respect about the development of digestive function and the digestion and absorption of lipids by the newborn. This review gives a detailed overview of the distinct functionalities that dietary lipids from human milk and infant formula provide and the profound differences in the physiology and biochemistry of lipid digestion between infants and adults. Fundamental mechanisms of infant lipid digestion can, however, almost exclusively be elucidated in vitro. Experimental approaches and their challenges are reviewed in depth.

  12. Resolving Rivalries and Realigning Goals: Challenges of Clinical and Research Multiteam Systems.

    Science.gov (United States)

    Gerber, David E; Reimer, Torsten; Williams, Erin L; Gill, Mary; Loudat Priddy, Laurin; Bergestuen, Deidi; Schiller, Joan H; Kirkpatrick, Haskell; Craddock Lee, Simon J

    2016-11-01

    This article describes the care processes for a 64-year-old man with newly diagnosed advanced non-small-cell lung cancer who was enrolled in a first-line clinical trial of a new immunotherapy regimen. The case highlights the concept of multiteam systems in cancer clinical research and clinical care. Because clinical research represents a highly dynamic entity-with studies frequently opening, closing, and undergoing modifications-concerted efforts of multiple teams are needed to respond to these changes while continuing to provide consistent, high-level care and timely, accurate clinical data. The case illustrates typical challenges of multiteam care processes. Compared with clinical tasks that are routinely performed by single teams, multiple-team care greatly increases the demands for communication, collaboration, cohesion, and coordination among team members. As the case illustrates, the described research team and clinical team are separated, resulting in suboptimal function. Individual team members interact predominantly with members of their own team. A considerable number of team members lack regular interaction with anyone outside their team. Accompanying this separation, the teams enact rivalries that impede collaboration. The teams have misaligned goals and competing priorities that create competition. Collective identity and cohesion across the two teams are low. Research team and clinical team members have limited knowledge of the roles and work of individuals outside their team. Recommendations to increase trust and collaboration are provided. Clinical providers and researchers may incorporate these themes into development and evaluation of multiteam systems, multidisciplinary teams, and cross-functional teams within their own institutions.

  13. Opportunities and challenges for 3D printing of solid-state lighting systems

    Science.gov (United States)

    Narendran, Nadarajah; Perera, Indika U.; Mou, Xi; Thotagamuwa, Dinusha R.

    2017-09-01

    Low energy use and reduced maintenance have made the LED, a solid-state light (SSL) source, the preferred technology for many lighting applications. With the explosion of products in the marketplace and subsequent price erosion, manufacturers are looking for lower cost materials and manufacturing methods. 3-D printing, also known as additive manufacturing, could be a potential solution. Recently, manufacturers in the automotive, aerospace, and medical industries have embraced 3-D printing for manufacturing parts and systems. This could pave the way for the lighting industry to produce lower cost, custom lighting systems that are 3-D printed on-site to achieve on-time and on-demand manufacturing. One unique aspect of LED fixture manufacturing is that it requires thermo-mechanical, electrical, and optical components. The goal of our investigation was to understand if current 3-D printing technologies and materials can be used to manufacture functional thermo-mechanical, electrical, and optical components for SSL fixtures. We printed heat sink components and electrical traces using an FFF-type 3-D printer with different filaments. The results showed that the printed heat sinks achieved higher thermal conductivity values compared to components made with plastic materials. For electrical traces, graphene-infused PLA showed low resistivity but it is much higher than bulk copper resistivity. For optics, SLA-printed optical components showed that print resolution, print orientation, and postprocessing affect light transmission and light scatter properties. Overall, 3-D printing offers an opportunity for mass customization of SSL fixtures and changing architectural lighting practice, but several challenges in terms of process and materials still have to be overcome.

  14. Progress in Harmonizing Tiered HIV Laboratory Systems: Challenges and Opportunities in 8 African Countries.

    Science.gov (United States)

    Williams, Jason; Umaru, Farouk; Edgil, Dianna; Kuritsky, Joel

    2016-09-28

    In 2014, the Joint United Nations Programme on HIV/AIDS released its 90-90-90 targets, which make laboratory diagnostics a cornerstone for measuring efforts toward the epidemic control of HIV. A data-driven laboratory harmonization and standardization approach is one way to create efficiencies and ensure optimal laboratory procurements. Following the 2008 "Maputo Declaration on Strengthening of Laboratory Systems"-a call for government leadership in harmonizing tiered laboratory networks and standardizing testing services-several national ministries of health requested that the United States Government and in-country partners help implement the recommendations by facilitating laboratory harmonization and standardization workshops, with a primary focus on improving HIV laboratory service delivery. Between 2007 and 2015, harmonization and standardization workshops were held in 8 African countries. This article reviews progress in the harmonization of laboratory systems in these 8 countries. We examined agreed-upon instrument lists established at the workshops and compared them against instrument data from laboratory quantification exercises over time. We used this measure as an indicator of adherence to national procurement policies. We found high levels of diversity across laboratories' diagnostic instruments, equipment, and services. This diversity contributes to different levels of compliance with expected service delivery standards. We believe the following challenges to be the most important to address: (1) lack of adherence to procurement policies, (2) absence or limited influence of a coordinating body to fully implement harmonization proposals, and (3) misalignment of laboratory policies with minimum packages of care and with national HIV care and treatment guidelines. Overall, the effort to implement the recommendations from the Maputo Declaration has had mixed success and is a work in progress. Program managers should continue efforts to advance the

  15. Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

    Directory of Open Access Journals (Sweden)

    Attila Oláh

    2017-11-01

    Full Text Available It is well known that certain active ingredients of the plants of Cannabis genus, i.e., the “phytocannabinoids” [pCBs; e.g., (−-trans-Δ9-tetrahydrocannabinol (THC, (−-cannabidiol, etc.] can influence a wide array of biological processes, and the human body is able to produce endogenous analogs of these substances [“endocannabinoids” (eCB, e.g., arachidonoylethanolamine (anandamide, AEA, 2-arachidonoylglycerol (2-AG, etc.]. These ligands, together with multiple receptors (e.g., CB1 and CB2 cannabinoid receptors, etc., and a complex enzyme and transporter apparatus involved in the synthesis and degradation of the ligands constitute the endocannabinoid system (ECS, a recently emerging regulator of several physiological processes. The ECS is widely expressed in the human body, including several members of the innate and adaptive immune system, where eCBs, as well as several pCBs were shown to deeply influence immune functions thereby regulating inflammation, autoimmunity, antitumor, as well as antipathogen immune responses, etc. Based on this knowledge, many in vitro and in vivo studies aimed at exploiting the putative therapeutic potential of cannabinoid signaling in inflammation-accompanied diseases (e.g., multiple sclerosis or in organ transplantation, and to dissect the complex immunological effects of medical and “recreational” marijuana consumption. Thus, the objective of the current article is (i to summarize the most recent findings of the field; (ii to highlight the putative therapeutic potential of targeting cannabinoid signaling; (iii to identify open questions and key challenges; and (iv to suggest promising future directions for cannabinoid-based drug development.

  16. Performance-Based Financing to Strengthen the Health System in Benin: Challenging the Mainstream Approach

    Directory of Open Access Journals (Sweden)

    Elisabeth Paul

    2018-01-01

    sustainability issues are also discussed. Conclusion BTC’s alternative PBF approach is both promising in terms of effects, ownership and sustainability, and less resource consuming. This experience testifies that PBF is not a uniform or rigid model, and opens the policy ground for recipient governments to put their own emphasis and priorities and design ad hoc models adapted to their context specificities. However, integrating PBF within the normal functioning of local health systems, in line with other reforms, is a big challenge.

  17. Applied & Computational MathematicsChallenges for the Design and Control of Dynamic Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D L; Burns, J A; Collis, S; Grosh, J; Jacobson, C A; Johansen, H; Mezic, I; Narayanan, S; Wetter, M

    2011-03-10

    ) Installation and commissioning - Current methodology and tools can target a three month window for commissioning of building subsystems; what is needed is one week. A 10X improvement is needed. (3) Quality - Current design tools can achieve 30% accuracy; what is needed to make design decisions is 5% with quantification of uncertainty. A 5X improvement is needed. These challenges cannot be overcome by raw computational power alone and require the development of new algorithms. Here algorithms mean much more than simulating the building physics but need to be inclusive of a much better understanding of the building and the control systems associated with the building and to capture the entire set of dynamics. The algorithmsmust represent computationally new mathematical approaches to modeling, simulation, optimization and control of large multi-scale dynamic systems and bringing these elements to bear on industry in simulation enabled design approaches.

  18. Challenges in the use of the mental health information system in a resource-limited setting: lessons from Ghana.

    Science.gov (United States)

    Kpobi, Lily; Swartz, Leslie; Ofori-Atta, Angela L

    2018-02-08

    One of the most successful modes of record-keeping and data collection is the use of health management information systems, where patient information and management plans are uniformly entered into a database to streamline the information and for ease of further patient management. For mental healthcare, a Mental Health Information System (MHIS) has been found most successful since a properly established and operational MHIS is helpful for developing equitable and appropriate mental health care systems. Until 2010, the system of keeping patient records and information in the Accra Psychiatric Hospital of Ghana was old and outdated. In light of this and other factors, a complete reforming of the mental health information systems in three psychiatric hospitals in Ghana was undertaken in 2010. Four years after its implementation, we explored user experiences with the new system, and report here the challenges that were identified with use of the new MHIS. Individual semi-structured interviews were conducted with nine clinical and administrative staff of the Accra Psychiatric Hospital to examine their experiences with the new MHIS. Participants in the study were in three categories: clinical staff, administrator, and records clerk. Participants' knowledge of the system and its use, as well as the challenges they had experienced in its use were explored using an interpretative phenomenological approach. The data suggest that optimal use of the current MHIS had faced significant implementation challenges in a number of areas. Central challenges reported by users included increased workload, poor staff involvement and training, and absence of logistic support to keep the system running. Setting up a new system does not guarantee its success. As important as it is to have a mental health information system, its usefulness is largely dependent on proper implementation and maintenance. Further, the system can facilitate policy transformation only when the place of mental

  19. Challenges with the introduction of radio-frequency identification systems into a manufacturer's supply chain - a pilot study

    Science.gov (United States)

    Kumar, Sameer; Kadow, Brooke B.; Lamkin, Melissa K.

    2011-05-01

    As radio-frequency identification (RFID) implementation becomes more widespread it is important for managers to consider if this technology is right for their businesses. This study examines challenges of RFID implementation along with a cost-benefit analysis of a pharmaceuticals manufacturer's supply chain. Research was gathered from a variety of sources on the topic of RFID to provide an in-depth analysis of challenges and benefits found with RFID systems. Furthermore, the study reviews the real case applications of the RFID technology in healthcare and customer services. Many of the challenges with RFID stem from improper planning of the synchronisation of the supply chain and the integration of RFID technology into facilities and software systems. Customer privacy, excess information and obsolete technology are also of concern to companies considering RFID. Benefits such as increased information sharing, product visibility and real-time information help to offset these challenges. In addition, pharmaceuticals manufacturer real case application showed cost savings from reducing labour and decreased opportunities for lost product counteract the expense to implement an RFID system. This study will be of value to managers who are attempting to implement RFID technology in their companies. It is intended that readers, both academics and practitioners, will be able to identify possible challenges and mitigate them as the RFID technology is put into practice.

  20. Dynamics of immune system gene expression upon bacterial challenge and wounding in a social insect (Bombus terrestris.

    Directory of Open Access Journals (Sweden)

    Silvio Erler

    2011-03-01

    Full Text Available The innate immune system which helps individuals to combat pathogens comprises a set of genes representing four immune system pathways (Toll, Imd, JNK and JAK/STAT. There is a lack of immune genes in social insects (e.g. honeybees when compared to Diptera. Potentially, this might be compensated by an advanced system of social immunity (synergistic action of several individuals. The bumble bee, Bombus terrestris, is a primitively eusocial species with an annual life cycle and colonies headed by a single queen. We used this key pollinator to study the temporal dynamics of immune system gene expression in response to wounding and bacterial challenge.Antimicrobial peptides (AMP (abaecin, defensin 1, hymenoptaecin were strongly up-regulated by wounding and bacterial challenge, the latter showing a higher impact on the gene expression level. Sterile wounding down-regulated TEP A, an effector gene of the JAK/STAT pathway, and bacterial infection influenced genes of the Imd (relish and JNK pathway (basket. Relish was up-regulated within the first hour after bacterial challenge, but decreased strongly afterwards. AMP expression following wounding and bacterial challenge correlates with the expression pattern of relish whereas correlated expression with dorsal was absent. Although expression of AMPs was high, continuous bacterial growth was observed throughout the experiment.Here we demonstrate for the first time the temporal dynamics of immune system gene expression in a social insect. Wounding and bacterial challenge affected the innate immune system significantly. Induction of AMP expression due to wounding might comprise a pre-adaptation to accompanying bacterial infections. Compared with solitary species this social insect exhibits reduced immune system efficiency, as bacterial growth could not be inhibited. A negative feedback loop regulating the Imd-pathway is suggested. AMPs, the end product of the Imd-pathway, inhibited the up-regulation of the

  1. Challenges, problems and possible solutions in wind generator systems from the aspect of forecast, planning and delivery of wind energy

    International Nuclear Information System (INIS)

    Giovski, Nikola

    2014-01-01

    The fundamental difficulties of integrating wind energy into the power system arise from its large temporal variability and limited predictability. That's why the integration of wind power presents major challenge for today's operating and planning practices of the power system operators. Accurate predictions of the possible wind power output, in time intervals relevant for creating schedules for production and exchange capacity, allows to system operators and dispatching personnel more efficient power system management. Despite the challenges and problems that arise due to integration of wind power into power systems, which need to be solved or reduced, wind power has its advantages that should be utilized. The effective integration of wind power plants into the transmission grid should allow them to represent the backbone of future energy systems. Modern wind generators represent production units that have the ability to participate in the management of energy systems e.g. in the regulation of frequency, voltage and other network operating requirements. This paper provides a brief overview of global experiences with the challenges, problems and possible solutions that appear in wind generator systems from the aspect of forecasting, planning and delivery of wind energy. (author)

  2. What do we know about the needs and challenges of health systems? A scoping review of the international literature.

    Science.gov (United States)

    Roncarolo, Federico; Boivin, Antoine; Denis, Jean-Louis; Hébert, Rejean; Lehoux, Pascale

    2017-09-08

    While there is an extensive literature on Health System (HS) strengthening and on the performance of specific HSs, there are few exhaustive syntheses of the challenges HSs are facing worldwide. This paper reports the findings of a scoping review aiming to classify the challenges of HSs investigated in the scientific literature. Specifically, it determines the kind of research conducted on HS challenges, where it was performed, in which health sectors and on which populations. It also identifies the types of challenge described the most and how they varied across countries. We searched 8 databases to identify scientific papers published in English, French and Italian between January 2000 and April 2016 that addressed HS needs and challenges. The challenges reported in the articles were classified using van Olmen et al.'s dynamic HS framework. Countries were classified using the Human Development Index (HDI). Our analyses relied on descriptive statistics and qualitative content analysis. 292 articles were included in our scoping review. 33.6% of these articles were empirical studies and 60.1% were specific to countries falling within the very high HDI category, in particular the United States. The most frequently researched sectors were mental health (41%), infectious diseases (12%) and primary care (11%). The most frequently studied target populations included elderly people (23%), people living in remote or poor areas (21%), visible or ethnic minorities (15%), and children and adolescents (15%). The most frequently reported challenges related to human resources (22%), leadership and governance (21%) and health service delivery (24%). While health service delivery challenges were more often examined in countries within the very high HDI category, human resources challenges attracted more attention within the low HDI category. This scoping review provides a quantitative description of the available evidence on HS challenges and a qualitative exploration of the

  3. Employment challenges in the future

    DEFF Research Database (Denmark)

    2011-01-01

    Discussion of challenges in employment challenges in Europe and a brief discription of the Danish flexicurity system......Discussion of challenges in employment challenges in Europe and a brief discription of the Danish flexicurity system...

  4. Design and challenges for a tsunami early warning system in the Marmara Sea

    Science.gov (United States)

    Necmioğlu, Öcal

    2016-01-01

    Since 1900, around 90,000 people have lost their lives in 76 earthquakes in Turkey, with a total affected population of around 7 million and direct losses of around 25 billion USD. Based on a time-dependent model that includes coseismic and post-seismic effects of the 1999 Kocaeli earthquake with moment magnitude Mw = 7.4, Parsons (J Geophys Res. 109, 2004) concluded that the probability of an earthquake with Mw > 7 in the Sea of Marmara near Istanbul is 35 to 70 % in the next 30 years. According to a 2011 study, an earthquake with Mw = 7.25 on the Main Marmara Fault is expected to heavily damage or destroy 2 to 4 % of around 1,000,000 buildings in Istanbul with a population around 13 million, with 9 to 15 % of the buildings receiving medium damage and 20 to 34 % of the buildings damaged lightly (Erdik, Science 341:72, 2013). In the absence of adequate post-earthquake assembly areas especially in the heavily urbanized Istanbul, it is evident that after a major earthquake, especially in the coastal parts of the city, citizens would be storming to landfill assembly and recreational areas. Besides earthquakes, around 30 tsunamis have been reported by Altınok et al. (Natural Hazards Earth System Science 11:273-293, 2011) in the Marmara Sea. Among those, catastrophic earthquakes such as 1509, 1766, and 1894 resulted in considerable tsunamis and some damage. The latest tsunami observed in Marmara was due to a triggered submarine landslide of the 1999 Mw = 7.4 Kocaeli earthquake which led to reported run-up heights of 1-3 m in most places (Tinti et al., Marine Geology 225:311-330, 2006). In this study, I propose a design for a tsunami warning system specific for the Marmara region that is strongly coupled with the earthquake early warning system (due to the short arrival times of tsunami) and stakeholders of the tsunami mitigation activities, such as local and regional components of disaster and emergency management and civil protection units, to ensure that the citizens

  5. Volcano alert level systems: managing the challenges of effective volcanic crisis communication

    Science.gov (United States)

    Fearnley, C. J.; Beaven, S.

    2018-05-01

    Over the last four decades, volcano observatories have adopted a number of different communication strategies for the dissemination of information on changes in volcanic behaviour and potential hazards to a wide range of user groups. These commonly include a standardised volcano alert level system (VALS), used in conjunction with other uni-valent communication techniques (such as information statements, reports and maps) and multi-directional techniques (such as meetings and telephone calls). This research, based on interviews and observation conducted 2007-2009 at the five US Geological Survey (USGS) volcano observatories, and including some of the key users of the VALS, argues for the importance of understanding how communicating volcanic hazard information takes place as an everyday social practice, focusing on the challenges of working across the boundaries between the scientific and decision-making communities. It is now widely accepted that the effective use, value and deployment of information across science-policy interfaces of this kind depend on three criteria: the scientific credibility of the information, its relevance to the needs of stakeholders and the legitimacy of both the information and the processes that produced it. Translation and two-way communication are required to ensure that all involved understand what information is credible and relevant. Findings indicate that whilst VALS play a role in raising awareness of an unfolding situation, supplementary communication techniques are crucial in facilitating situational understanding of that situation, and the uncertainties inherent to its scientific assessment, as well as in facilitating specific responses. In consequence, `best practice' recommendations eschew further standardisation, and focus on the in situ cultivation of dialogue between scientists and stakeholders as a means of ensuring that information, and the processes through which it is produced are perceived to be legitimate by all

  6. Progress in Harmonizing Tiered HIV Laboratory Systems: Challenges and Opportunities in 8 African Countries

    Science.gov (United States)

    Williams, Jason; Umaru, Farouk; Edgil, Dianna; Kuritsky, Joel

    2016-01-01

    ABSTRACT In 2014, the Joint United Nations Programme on HIV/AIDS released its 90-90-90 targets, which make laboratory diagnostics a cornerstone for measuring efforts toward the epidemic control of HIV. A data-driven laboratory harmonization and standardization approach is one way to create efficiencies and ensure optimal laboratory procurements. Following the 2008 “Maputo Declaration on Strengthening of Laboratory Systems”—a call for government leadership in harmonizing tiered laboratory networks and standardizing testing services—several national ministries of health requested that the United States Government and in-country partners help implement the recommendations by facilitating laboratory harmonization and standardization workshops, with a primary focus on improving HIV laboratory service delivery. Between 2007 and 2015, harmonization and standardization workshops were held in 8 African countries. This article reviews progress in the harmonization of laboratory systems in these 8 countries. We examined agreed-upon instrument lists established at the workshops and compared them against instrument data from laboratory quantification exercises over time. We used this measure as an indicator of adherence to national procurement policies. We found high levels of diversity across laboratories’ diagnostic instruments, equipment, and services. This diversity contributes to different levels of compliance with expected service delivery standards. We believe the following challenges to be the most important to address: (1) lack of adherence to procurement policies, (2) absence or limited influence of a coordinating body to fully implement harmonization proposals, and (3) misalignment of laboratory policies with minimum packages of care and with national HIV care and treatment guidelines. Overall, the effort to implement the recommendations from the Maputo Declaration has had mixed success and is a work in progress. Program managers should continue efforts to

  7. Web-based communications systems: innovate solutions to complex development challenges

    International Nuclear Information System (INIS)

    Levy, D.S.; Sordi, G.M.; Villavicencio, A.L.H.; Biazini Filho, F.

    2015-01-01

    This research work focus on the potential value of Information and Communication Technologies (ICTs) to enhance communication and education on Radiological Protection throughout Brazil. ICTs present unprecedented opportunities to innovate solutions to complex development issues, in this large country where it is a strong challenge to ensure access to information to as many people as possible, minimizing costs and optimizing results. Therefore, taking advantage of the impact of ICTs in modern Information Society and its institutions, some research works include education for workers, researchers and the public, offering conditions for learning and improving professional and personal skills. UNIPRORAD is a research work of informatization of radiological protection programs to offer unified programs and inter-related information in Portuguese. The system provides Brazilian facilities and researchers a complete repository for research, consultation and information. The content includes the best practices for optimization and monitoring programs, taking into account that in order to establish a Radiation Protection Plan or a Radiation Emergency Plan, there must be observed all procedures based on national and international recommendations published by different organizations over the past decades: International Commission on Radiological Protection (ICRP), International Atomic Energy Agency (IAEA) and National Nuclear Energy Commission (CNEN). Other than the efforts to disseminate information to radioactive facilities and researches, it is equally essential to invest in education and communication to increase public knowledge and understanding of the benefits of Nuclear Technology, such as food irradiation and social responsibility for electric power generation, for public acceptance of Nuclear Technology depends on public understanding of radiation and its effects on individuals, workers and environment. This research work aims to present several important initiatives

  8. Challenges and perspectives in Service Design curricula. The case of the Service Systems Design Master of Aalborg University in Copenhagen

    DEFF Research Database (Denmark)

    Götzen, Amalia De; Morelli, Nicola; Grani, Francesco

    2014-01-01

    In this paper the new Master program on Service Systems Design at Aalborg University in Copenhagen will be presented, focusing on the challenges of building such a curriculum and on its peculiar approach to Service Design through the Problem Based Learning methodology. All the semesters will be d...

  9. Introduction of Geographical Information Systems (GIS) in Technical University Education in Ghana: Challenges and the Way Forward

    Science.gov (United States)

    Acquah, Prince C.; Asamoah, Jack N.; Konadu, Daniel D.

    2017-01-01

    Geographic Information System (GIS) continue to play very important role in improving spatial thinking skills of graduates from higher educational institutions. However, teaching and learning of GIS at the technical university level in Ghana remains very limited due to some implementation challenges. This paper reviews the implementation of GIS in…

  10. Challenges in IC design for hearing aids

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    2012-01-01

    Designing modern hearing aids is a formidable challenge. The size of hearing aids is constantly decreasing, making them virtually invisible today. Still, as in all other modern electronics, more and more features are added to these devices driven by the development in modern IC technology....... The demands for performance and features at very low supply voltage and power consumption constantly prove a challenge to the physical design of hearing aids and not at least the design of the ICs for these. As a result of this all large hearing aid manufacturers use fully customized ASICs in their products...... to produce a competitive advantage. This presentation will give a brief insight into the hearing aid market and industry, a brief view of the historic development of hearing aids and an introduction to how a modern hearing is constructed showing the amplifier as the key component in the modern hearing aid...

  11. WE-EF-BRD-02: Battling Maxwell’s Equations: Physics Challenges and Solutions for Hybrid MRI Systems

    Energy Technology Data Exchange (ETDEWEB)

    Keall, P. [University of Sydney (Australia)

    2015-06-15

    MRI-guided treatment is a growing area of medicine, particularly in radiotherapy and surgery. The exquisite soft tissue anatomic contrast offered by MRI, along with functional imaging, makes the use of MRI during therapeutic procedures very attractive. Challenging the utility of MRI in the therapy room are many issues including the physics of MRI and the impact on the environment and therapeutic instruments, the impact of the room and instruments on the MRI; safety, space, design and cost. In this session, the applications and challenges of MRI-guided treatment will be described. The session format is: Past, present and future: MRI-guided radiotherapy from 2005 to 2025: Jan Lagendijk Battling Maxwell’s equations: Physics challenges and solutions for hybrid MRI systems: Paul Keall I want it now!: Advances in MRI acquisition, reconstruction and the use of priors to enable fast anatomic and physiologic imaging to inform guidance and adaptation decisions: Yanle Hu MR in the OR: The growth and applications of MRI for interventional radiology and surgery: Rebecca Fahrig Learning Objectives: To understand the history and trajectory of MRI-guided radiotherapy To understand the challenges of integrating MR imaging systems with linear accelerators To understand the latest in fast MRI methods to enable the visualisation of anatomy and physiology on radiotherapy treatment timescales To understand the growing role and challenges of MRI for image-guided surgical procedures My disclosures are publicly available and updated at: http://sydney.edu.au/medicine/radiation-physics/about-us/disclosures.php.

  12. WE-EF-BRD-02: Battling Maxwell’s Equations: Physics Challenges and Solutions for Hybrid MRI Systems

    International Nuclear Information System (INIS)

    Keall, P.

    2015-01-01

    MRI-guided treatment is a growing area of medicine, particularly in radiotherapy and surgery. The exquisite soft tissue anatomic contrast offered by MRI, along with functional imaging, makes the use of MRI during therapeutic procedures very attractive. Challenging the utility of MRI in the therapy room are many issues including the physics of MRI and the impact on the environment and therapeutic instruments, the impact of the room and instruments on the MRI; safety, space, design and cost. In this session, the applications and challenges of MRI-guided treatment will be described. The session format is: Past, present and future: MRI-guided radiotherapy from 2005 to 2025: Jan Lagendijk Battling Maxwell’s equations: Physics challenges and solutions for hybrid MRI systems: Paul Keall I want it now!: Advances in MRI acquisition, reconstruction and the use of priors to enable fast anatomic and physiologic imaging to inform guidance and adaptation decisions: Yanle Hu MR in the OR: The growth and applications of MRI for interventional radiology and surgery: Rebecca Fahrig Learning Objectives: To understand the history and trajectory of MRI-guided radiotherapy To understand the challenges of integrating MR imaging systems with linear accelerators To understand the latest in fast MRI methods to enable the visualisation of anatomy and physiology on radiotherapy treatment timescales To understand the growing role and challenges of MRI for image-guided surgical procedures My disclosures are publicly available and updated at: http://sydney.edu.au/medicine/radiation-physics/about-us/disclosures.php

  13. Policy challenges for the pediatric rheumatology workforce: Part II. Health care system delivery and workforce supply.

    Science.gov (United States)

    Henrickson, Michael

    2011-01-01

    The United States pediatric population with chronic health conditions is expanding. Currently, this demographic comprises 12-18% of the American child and youth population. Affected children often receive fragmented, uncoordinated care. Overall, the American health care delivery system produces modest outcomes for this population. Poor, uninsured and minority children may be at increased risk for inferior coordination of services. Further, the United States health care delivery system is primarily organized for the diagnosis and treatment of acute conditions. For pediatric patients with chronic health conditions, the typical acute problem-oriented visit actually serves as a barrier to care. The biomedical model of patient education prevails, characterized by unilateral transfer of medical information. However, the evidence basis for improvement in disease outcomes supports the use of the chronic care model, initially proposed by Dr. Edward Wagner. Six inter-related elements distinguish the success of the chronic care model, which include self-management support and care coordination by a prepared, proactive team. United States health care lacks a coherent policy direction for the management of high cost chronic conditions, including rheumatic diseases. A fundamental restructure of United States health care delivery must urgently occur which places the patient at the center of care. For the pediatric rheumatology workforce, reimbursement policies and the actions of health plans and insurers are consistent barriers to chronic disease improvement. United States reimbursement policy and overall fragmentation of health care services pose specific challenges for widespread implementation of the chronic care model. Team-based multidisciplinary care, care coordination and self-management are integral to improve outcomes. Pediatric rheumatology demand in the United States far exceeds available workforce supply. This article reviews the career choice decision-making process

  14. EUROPEAN PENSION SYSTEMS - THE REAL CHALLENGE OF THE 21ST CENTURY

    Directory of Open Access Journals (Sweden)

    Maria Augusztinovics

    2003-07-01

    Full Text Available It will be argued that the present focus of the pension reform debate - public, pay-as-you-go versus private, funded - is misplaced and somewhat outdated. Pay-as-you-go versus funding or pre-funding is a more-or-less technical issue. The public versus private choice should be seen as a cost-benefit, efficiency problem. These two dichotomies represent important, but secondary problems. (They cannot even be expected to help solving the certainly serious - although not that catastrophic as often painted - problems caused by the foreseeable demographic changes, the so-called ageing of the population. The major distinctive attribute of existing European pension schemes is not the mode of financing or management. It is the Bismarckian heritage, the close link to employment, based on the typically 20th century-type, continuous working career. A presently emerging trend, however, is the transformation of the labour market. The so-called "atypical" forms of employment (part-time work, outsourcing, work at home, fixed-length contracts, etc. are spreading and the traditional employer-employee link is weakening, if not - at least partially - disappearing. Activity ratios (poorly represented by the unemployment rate are declining. This trend will probably be accentuated by the deepening of globalization and European integration, the growing importance of migration, including temporary migration (i.e. working in one country for a few years, then in another one, then maybe returning home for retirement. The questions thus arise: how, when, where will people, who are economically "inactive" or wandering around during a large faction of their earning span, acquire pension eligibility, sufficient for income security in old age? Will the present forms of pension insurance (including social security as well as country-based private funds be able to live up to this 21st century-type of challenge? If not, what are the adequate models for the future and what are the

  15. Policy challenges for the pediatric rheumatology workforce: Part II. Health care system delivery and workforce supply

    Directory of Open Access Journals (Sweden)

    Henrickson Michael

    2011-08-01

    Full Text Available Abstract The United States pediatric population with chronic health conditions is expanding. Currently, this demographic comprises 12-18% of the American child and youth population. Affected children often receive fragmented, uncoordinated care. Overall, the American health care delivery system produces modest outcomes for this population. Poor, uninsured and minority children may be at increased risk for inferior coordination of services. Further, the United States health care delivery system is primarily organized for the diagnosis and treatment of acute conditions. For pediatric patients with chronic health conditions, the typical acute problem-oriented visit actually serves as a barrier to care. The biomedical model of patient education prevails, characterized by unilateral transfer of medical information. However, the evidence basis for improvement in disease outcomes supports the use of the chronic care model, initially proposed by Dr. Edward Wagner. Six inter-related elements distinguish the success of the chronic care model, which include self-management support and care coordination by a prepared, proactive team. United States health care lacks a coherent policy direction for the management of high cost chronic conditions, including rheumatic diseases. A fundamental restructure of United States health care delivery must urgently occur which places the patient at the center of care. For the pediatric rheumatology workforce, reimbursement policies and the actions of health plans and insurers are consistent barriers to chronic disease improvement. United States reimbursement policy and overall fragmentation of health care services pose specific challenges for widespread implementation of the chronic care model. Team-based multidisciplinary care, care coordination and self-management are integral to improve outcomes. Pediatric rheumatology demand in the United States far exceeds available workforce supply. This article reviews the career

  16. Key challenges and recent progress in batteries, fuel cells, and hydrogen storage for clean energy systems

    Science.gov (United States)

    Chalk, Steven G.; Miller, James F.

    Reducing or eliminating the dependency on petroleum of transportation systems is a major element of US energy research activities. Batteries are a key enabling technology for the development of clean, fuel-efficient vehicles and are key to making today's hybrid electric vehicles a success. Fuel cells are the key enabling technology for a future hydrogen economy and have the potential to revolutionize the way we power our nations, offering cleaner, more efficient alternatives to today's technology. Additionally fuel cells are significantly more energy efficient than combustion-based power generation technologies. Fuel cells are projected to have energy efficiency twice that of internal combustion engines. However before fuel cells can realize their potential, significant challenges remain. The two most important are cost and durability for both automotive and stationary applications. Recent electrocatalyst developments have shown that Pt alloy catalysts have increased activity and greater durability than Pt catalysts. The durability of conventional fluorocarbon membranes is improving, and hydrocarbon-based membranes have also shown promise of equaling the performance of fluorocarbon membranes at lower cost. Recent announcements have also provided indications that fuel cells can start from freezing conditions without significant deterioration. Hydrogen storage systems for vehicles are inadequate to meet customer driving range expectations (>300 miles or 500 km) without intrusion into vehicle cargo or passenger space. The United States Department of Energy has established three centers of Excellence for hydrogen storage materials development. The centers are focused on complex metal hydrides that can be regenerated onboard a vehicle, chemical hydrides that require off-board reprocessing, and carbon-based storage materials. Recent developments have shown progress toward the 2010 DOE targets. In addition DOE has established an independent storage material testing center

  17. Liquid lithium loop system to solve challenging technology issues for fusion power plant

    Science.gov (United States)

    Ono, M.; Majeski, R.; Jaworski, M. A.; Hirooka, Y.; Kaita, R.; Gray, T. K.; Maingi, R.; Skinner, C. H.; Christenson, M.; Ruzic, D. N.

    2017-11-01

    Steady-state fusion power plant designs present major divertor technology challenges, including high divertor heat flux both in steady-state and during transients. In addition to these concerns, there are the unresolved technology issues of long term dust accumulation and associated tritium inventory and safety issues. It has been suggested that radiation-based liquid lithium (LL) divertor concepts with a modest lithium-loop could provide a possible solution for these outstanding fusion reactor technology issues, while potentially improving reactor plasma performance. The application of lithium (Li) in NSTX resulted in improved H-mode confinement, H-mode power threshold reduction, and reduction in the divertor peak heat flux while maintaining essentially Li-free core plasma operation even during H-modes. These promising results in NSTX and related modeling calculations motivated the radiative liquid lithium divertor concept and its variant, the active liquid lithium divertor concept, taking advantage of the enhanced or non-coronal Li radiation in relatively poorly confined divertor plasmas. To maintain the LL purity in a 1 GW-electric class fusion power plant, a closed LL loop system with a modest circulating capacity of ~1 l s-1 is envisioned. We examined two key technology issues: (1) dust or solid particle removal and (2) real time recovery of tritium from LL while keeping the tritium inventory level to an acceptable level. By running the LL-loop continuously, it can carry the dust particles and impurities generated in the vacuum vessel to the outside where the dust/impurities can be removed by relatively simple dust filter, cold trap and/or centrifugal separation systems. With ~1 l s-1 LL flow, even a small 0.1% dust content by weight (or 0.5 g s-1) suggests that the LL-loop could carry away nearly 16 tons of dust per year. In a 1 GW-electric (or ~3 GW fusion power) fusion power plant, about 0.5 g s-1 of tritium is needed to maintain the fusion fuel cycle

  18. Prevention of Congenital Transmission of Malaria in Sub-Saharan African Countries: Challenges and Implications for Health System Strengthening

    OpenAIRE

    Osungbade, Kayode O.; Oladunjoye, Olubunmi O.

    2012-01-01

    Objectives. Review of burden of congenital transmission of malaria, challenges of preventive measures, and implications for health system strengthening in sub-Saharan Africa. Methods. Literature from Pubmed (MEDLINE), Biomed central, Google Scholar, and Cochrane Database were reviewed. Results. The prevalence of congenital malaria in sub-Saharan Africa ranges from 0 to 23%. Diagnosis and existing preventive measures are constantly hindered by weak health systems and sociocultural issues. WHO ...

  19. Identifying and evaluating high risk areas and challenges on marine drilling riser system in relation to deepwater problems

    OpenAIRE

    Iversen, Alexander

    2012-01-01

    Master's thesis in Offshore technology The main concerns during drilling operations are riser integrity and maintaining well control. This thesis has mainly been focusing on the problems and challenges faced with the marine riser system to illuminate high risk areas related to riser integrity. A marine riser system consists generally of four main elements; the upper marine riser package, riser joints, lower marine riser package, and the blowout preventer, each playing an important par...

  20. WE-AB-201-01: Treatment Planning System Commissioning and QA: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Salomons, G. [Cancer Center of Southeastern Ontario (Canada)

    2015-06-15

    Treatment planning systems (TPS) are a cornerstone of modern radiation therapy. Errors in their commissioning or use can have a devastating impact on many patients. To support safe and high quality care, medical physicists must conduct efficient and proper commissioning, good clinical integration, and ongoing quality assurance (QA) of the TPS. AAPM Task Group 53 and related publications have served as seminal benchmarks for TPS commissioning and QA over the past two decades. Over the same time, continuing innovations have made the TPS even more complex and more central to the clinical process. Medical goals are now expressed in terms of the dose and margins around organs and tissues that are delineated from multiple imaging modalities (CT, MR and PET); and even temporally resolved (i.e., 4D) imaging. This information is passed on to optimization algorithms to establish accelerator movements that are programmed directly for IMRT, VMAT and stereotactic treatments. These advances have made commissioning and QA of the TPS much more challenging. This education session reviews up-to-date experience and guidance on this subject; including the recently published AAPM Medical Physics Practice Guideline (MPPG) #5 “Commissioning and QA of Treatment Planning Dose Calculations: Megavoltage Photon and Electron Beams”. Treatment Planning System Commissioning and QA: Challenges and Opportunities (Greg Salomons) This session will provide some key background and review publications describing prominent incidents relating to TPS commissioning and QA. Traditional approaches have been hardware and feature oriented. They aim to establish a functional configuration and establish specifications for regular testing of features (like dose calculation) to assure stable operation and detect failures. With the advent of more complex systems, more patient-specific testing has also been adopted. A number of actual TPS defects will be presented along with heuristics for identifying similar

  1. WE-AB-201-01: Treatment Planning System Commissioning and QA: Challenges and Opportunities

    International Nuclear Information System (INIS)

    Salomons, G.

    2015-01-01

    Treatment planning systems (TPS) are a cornerstone of modern radiation therapy. Errors in their commissioning or use can have a devastating impact on many patients. To support safe and high quality care, medical physicists must conduct efficient and proper commissioning, good clinical integration, and ongoing quality assurance (QA) of the TPS. AAPM Task Group 53 and related publications have served as seminal benchmarks for TPS commissioning and QA over the past two decades. Over the same time, continuing innovations have made the TPS even more complex and more central to the clinical process. Medical goals are now expressed in terms of the dose and margins around organs and tissues that are delineated from multiple imaging modalities (CT, MR and PET); and even temporally resolved (i.e., 4D) imaging. This information is passed on to optimization algorithms to establish accelerator movements that are programmed directly for IMRT, VMAT and stereotactic treatments. These advances have made commissioning and QA of the TPS much more challenging. This education session reviews up-to-date experience and guidance on this subject; including the recently published AAPM Medical Physics Practice Guideline (MPPG) #5 “Commissioning and QA of Treatment Planning Dose Calculations: Megavoltage Photon and Electron Beams”. Treatment Planning System Commissioning and QA: Challenges and Opportunities (Greg Salomons) This session will provide some key background and review publications describing prominent incidents relating to TPS commissioning and QA. Traditional approaches have been hardware and feature oriented. They aim to establish a functional configuration and establish specifications for regular testing of features (like dose calculation) to assure stable operation and detect failures. With the advent of more complex systems, more patient-specific testing has also been adopted. A number of actual TPS defects will be presented along with heuristics for identifying similar

  2. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges

    International Nuclear Information System (INIS)

    Hannan, M.A.; Abdulla Al Mamun, Md.; Hussain, Aini; Basri, Hassan; Begum, R.A.

    2015-01-01

    Highlights: • Classification of available technologies for SWM system in four core category. • Organization of technology based SWM systems in three main groups. • Summary of SWM systems with target application, methodology and functional domain. • Issues and challenges are highlighted for further design of a sustainable system. - Abstract: In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system

  3. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Hannan, M.A., E-mail: hannan@eng.ukm.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Abdulla Al Mamun, Md., E-mail: md.abdulla@siswa.ukm.edu.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Hussain, Aini, E-mail: aini@eng.ukm.my [Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Basri, Hassan, E-mail: drhb@ukm.my [Department of Civil and Structural Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia); Begum, R.A., E-mail: rawshan@ukm.edu.my [Institute of Climate Change, Universiti Kebangsaan Malaysia, Bangi, Selangor DE (Malaysia)

    2015-09-15

    Highlights: • Classification of available technologies for SWM system in four core category. • Organization of technology based SWM systems in three main groups. • Summary of SWM systems with target application, methodology and functional domain. • Issues and challenges are highlighted for further design of a sustainable system. - Abstract: In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system.

  4. Challenges to the Israeli healthcare system: attracting medical students to primary care and to the periphery.

    Science.gov (United States)

    Weissman, Charles; Zisk-Rony, Rachel Yaffa; Avidan, Alexander; Elchalal, Uriel; Tandeter, Howard

    2018-05-29

    The greatest challenges facing healthcare systems include ensuring a sufficient supply of primary care physicians and physicians willing to work in rural or peripheral areas. Especially challenging is enticing young physicians to practice primary care in rural/peripheral areas. Identifying medical students interested in primary care and in residencies in Israel's periphery should aid the healthcare leadership. It may be particularly important to do so during the clinical years, as this is the stage at which many future physicians begin to crystallize their specialty and location preferences. Questionnaires, distributed to 6 consecutive 5th-year classes of the Hebrew University - Hadassah School of Medicine, from 2010 to 2016, elicited information on criteria for choosing a career specialty, criteria for choosing a residency program and whether one-time monetary grants authorized in the 2011 physicians' union contract would attract students to residencies in the periphery. Completed questionnaires were returned by 511 of 740 (69%) students. Ninety-eight (19%) were interested in a primary care residency, 184 (36%) were unsure and 229 (45%) were not interested. Students interested in primary care were significantly less interested in specialties that perform procedures/surgeries and in joining a medical school faculty, while being more inclined towards specialties dealing with social problems, controllable lifestyles and working limited hours. The percentage of students interested in primary care was stable during the study period. Forty-eight of the students indicated interest in residencies in the country's periphery, and 42% of them were also interested in primary care residencies. Overall, only 3.7% of students were interested in both a primary care residency and a residency in the periphery. Thirty percent of the students indicated that the monetary incentives tempted them to consider a residency in the periphery. Fifty-three percent of these students reported

  5. Alternative and augmentative communication systems (AACS as an instrument for decreasing challenging behaviour to students with ASD: a case study

    Directory of Open Access Journals (Sweden)

    Rosa Mira Pastor

    2017-06-01

    Full Text Available An intervention based on the Benson Schaeffer’s Speak Signal Program, to provide an eight years old girl with Autism Spectrum Disorder (ASD with the Alternative and Augmentative Communication System (AACS is described. The intervention aims at promoting the use of signs to express her needs and through this achieve a decrease in challenging behaviors, mostly produced when trying to communicate. A qualitative single case study by objective methodology was used. The program was developed in the communication and language classroom of a public school for children in nursery and primary education in Valencia. Eight signs worked functionally in different contexts. Likewise, reduction of challenging behavior was evident.

  6. Robot-assisted pyeloplasty for pelvi-ureteric junction obstruction of lower moiety in partial duplex system: A technical challenge

    Directory of Open Access Journals (Sweden)

    Girdhar S Bora

    2016-01-01

    Full Text Available Management of pelvi-ureteric junction obstruction (PUJO in a duplex system is technically challenging as dissection at the pelvis may jeopardize the vascularity of the normal moiety ureter. Anastomosing the pelvis to the one single ureter will have a risk of future development of stricture which then will risk both the moieties. Robotic assistance enables appropriate tissue dissection; minimal handling of normal ureter and precision in suturing, overcoming the potential challenges involved in the minimally invasive management of such complex cases. We report the feasibility and efficacy of robot-assisted laparoscopic pyeloplasty in such case.

  7. Applying a framework for assessing the health system challenges to scaling up mHealth in South Africa

    Directory of Open Access Journals (Sweden)

    Leon Natalie

    2012-11-01

    Full Text Available Abstract Background Mobile phone technology has demonstrated the potential to improve health service delivery, but there is little guidance to inform decisions about acquiring and implementing mHealth technology at scale in health systems. Using the case of community-based health services (CBS in South Africa, we apply a framework to appraise the opportunities and challenges to effective implementation of mHealth at scale in health systems. Methods A qualitative study reviewed the benefits and challenges of mHealth in community-based services in South Africa, through a combination of key informant interviews, site visits to local projects and document reviews. Using a framework adapted from three approaches to reviewing sustainable information and communication technology (ICT, the lessons from local experience and elsewhere formed the basis of a wider consideration of scale up challenges in South Africa. Results Four key system dimensions were identified and assessed: government stewardship and the organisational, technological and financial systems. In South Africa, the opportunities for successful implementation of mHealth include the high prevalence of mobile phones, a supportive policy environment for eHealth, successful use of mHealth for CBS in a number of projects and a well-developed ICT industry. However there are weaknesses in other key health systems areas such as organisational culture and capacity for using health information for management, and the poor availability and use of ICT in primary health care. The technological challenges include the complexity of ensuring interoperability and integration of information systems and securing privacy of information. Finally, there are the challenges of sustainable financing required for large scale use of mobile phone technology in resource limited settings. Conclusion Against a background of a health system with a weak ICT environment and limited implementation capacity, it remains

  8. Challenges in predicting climate and environmental effects on vector-borne disease episystems in a changing world.

    Science.gov (United States)

    Tabachnick, W J

    2010-03-15

    Vector-borne pathogens cause enormous suffering to humans and animals. Many are expanding their range into new areas. Dengue, West Nile and Chikungunya have recently caused substantial human epidemics. Arthropod-borne animal diseases like Bluetongue, Rift Valley fever and African horse sickness pose substantial threats to livestock economies around the world. Climate change can impact the vector-borne disease epidemiology. Changes in climate will influence arthropod vectors, their life cycles and life histories, resulting in changes in both vector and pathogen distribution and changes in the ability of arthropods to transmit pathogens. Climate can affect the way pathogens interact with both the arthropod vector and the human or animal host. Predicting and mitigating the effects of future changes in the environment like climate change on the complex arthropod-pathogen-host epidemiological cycle requires understanding of a variety of complex mechanisms from the molecular to the population level. Although there has been substantial progress on many fronts the challenges to effectively understand and mitigate the impact of potential changes in the environment on vector-borne pathogens are formidable and at an early stage of development. The challenges will be explored using several arthropod-borne pathogen systems as illustration, and potential avenues to meet the challenges will be presented.

  9. A review of human factors challenges of complex adaptive systems: discovering and understanding chaos in human performance.

    Science.gov (United States)

    Karwowski, Waldemar

    2012-12-01

    In this paper, the author explores a need for a greater understanding of the true nature of human-system interactions from the perspective of the theory of complex adaptive systems, including the essence of complexity, emergent properties of system behavior, nonlinear systems dynamics, and deterministic chaos. Human performance, more often than not, constitutes complex adaptive phenomena with emergent properties that exhibit nonlinear dynamical (chaotic) behaviors. The complexity challenges in the design and management of contemporary work systems, including service systems, are explored. Examples of selected applications of the concepts of nonlinear dynamics to the study of human physical performance are provided. Understanding and applications of the concepts of theory of complex adaptive and dynamical systems should significantly improve the effectiveness of human-centered design efforts of a large system of systems. Performance of many contemporary work systems and environments may be sensitive to the initial conditions and may exhibit dynamic nonlinear properties and chaotic system behaviors. Human-centered design of emergent human-system interactions requires application of the theories of nonlinear dynamics and complex adaptive system. The success of future human-systems integration efforts requires the fusion of paradigms, knowledge, design principles, and methodologies of human factors and ergonomics with those of the science of complex adaptive systems as well as modern systems engineering.

  10. Technical Challenges in the Application and Licensing of Digital Instrumentation and Control Systems in Nuclear Power Plants

    International Nuclear Information System (INIS)

    2015-01-01

    With the modernization of existing analogue instrumentation and control (I&C) systems in nuclear power plants through digital I&C technology, and the implementation of digital I&C systems in new plants, the industry is faced with significant challenges. These challenges appear in the form of difficulties in managing the necessarily incremental transition, highly integrated (and interdependent) architectures, the flexible configurability enabled by digital technology, and uncertainty and inconsistency in licensing digital I&C systems and equipment in the different Member States. This publication discusses 17 major issues that utilities, developers, suppliers and regulatory stakeholders need to consider, so that the industry can capture and benefit from shared experience, recent technological developments, and emerging best practices

  11. Qualitative analysis of round-table discussions on the business case and procurement challenges for hospital electronic prescribing systems.

    Directory of Open Access Journals (Sweden)

    Kathrin M Cresswell

    Full Text Available There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making.We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9.We drew on data from 17 participants (approximately eight per roundtable, six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing "wants" and aspirations from organizational "needs".Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management.

  12. Challenges in using geographic information systems (GIS to understand and control malaria in Indonesia

    Directory of Open Access Journals (Sweden)

    Dale Pat

    2003-11-01

    Full Text Available Abstract Malaria is a mosquito-borne disease of global concern with 1.5 to 2.7 million people dying each year and many more suffering from it. In Indonesia, malaria is a major public health issue with around six million clinical cases and 700 deaths each year. Malaria is most prevalent in the developing countries of the world. Aid agencies have provided financial and technical assistance to malaria-prone countries in an effort to battle the disease. Over the past decade, the focus of some of this assistance has been in the provision of geographic information systems (GIS hardware, software and training. In theory, GIS can be a very effective tool in combating malaria, however, in practice there have been a host of challenges to its successful use. This review is based, in part, on the literature but also on our experience working with the Indonesian Ministry of Health. The review identifies three broad problem areas. The first of these relates to data concerns. Without adequate data, GIS is not very useful. Specific problem areas include: accurate data on the disease and how it is reported; basic environmental data on vegetation, land uses, topography, rainfall, etc.; and demographic data on the movement of people. The second problem area involves technology – specifically computer hardware, GIS software and training. The third problem area concerns methods – assuming the previous data and technological problems have been resolved – how can GIS be used to improve our understanding of malaria? One of the main methodological tools is spatial statistical analysis, however, this is a newly developing field, is not easy to understand and suffers from the fact that there is no agreement on standard methods of analysis. The paper concludes with a discussion of strategies that can be used to overcome some of these problems. One of these strategies involves using ArcView GIS software in combination with ArcExplorer (a public domain program that can

  13. Strengthening preventive care programs: a permanent challenge for healthcare systems; lessons from PREVENIMSS México

    Directory of Open Access Journals (Sweden)

    Cantón Sonia

    2010-07-01

    new challenges that this healthcare system faces. The unsolved problems such as anemia, and the emerging ones such as overweight, obesity, among others, point out the need to strength preventive care through designing and implementing innovative programs aimed to attain effective coverage for those conditions in which prevention obtains substandard results.

  14. Towards large-scale data analysis: challenges in the design of portable systems and use of Cloud computing.

    Science.gov (United States)

    Diaz, Javier; Arrizabalaga, Saioa; Bustamante, Paul; Mesa, Iker; Añorga, Javier; Goya, Jon

    2013-01-01

    Portable systems and global communications open a broad spectrum for new health applications. In the framework of electrophysiological applications, several challenges are faced when developing portable systems embedded in Cloud computing services. In order to facilitate new developers in this area based on our experience, five areas of interest are presented in this paper where strategies can be applied for improving the performance of portable systems: transducer and conditioning, processing, wireless communications, battery and power management. Likewise, for Cloud services, scalability, portability, privacy and security guidelines have been highlighted.

  15. Ebola and Immune System

    OpenAIRE

    KOMENAN, Alexis

    2016-01-01

    Ebola hemorrhagic fever is a formidable disease whose surges always result in a high number of victims in sub-Saharan Africa. There is no official treatment against the virus, which makes the task of containment extremely delicate. However, the existence of survivors to the virus demonstrates curable nature of the disease and suggests the existence of favorable factors of immunity. The author examines these factors and their challenges and perspectives in the cure of the disease.

  16. Analysis of Factors Affecting System Performance in the ASpIRE Challenge

    Science.gov (United States)

    2015-12-13

    performance in the ASpIRE ( Automatic Speech recognition In Reverberant Environments) challenge. In particular, overall word error rate (WER) of the solver...in mismatched conditions. Index Terms: speech recognition, reverberant rooms, microphone audio 1. Introduction The development of automatic ...IEEE Workshop on Automatic Speech Recognition and Understanding, 2005. [7] Harper, M., The Automatic Speech Recognition in Reverberant

  17. Activity-Based Management System Implementation in Higher Education Institution: Benefits and Challenges

    Science.gov (United States)

    Ismail, Noor Azizi

    2010-01-01

    Purpose: The purpose of this paper is to discuss how activity-based costing (ABC) technique can be applied in the context of higher education institutions. It also discusses the obstacles and challenges to the successful implementation of activity-based management (ABM) in the higher education environment. Design/methodology/approach: This paper…

  18. Towards Achieving a Critical Thinking Society in Malaysia: A Challenge to School Libraries and Educational Systems.

    Science.gov (United States)

    Yaacob, Raja Abdullah; Seman, Norma Abur

    One of the challenges facing Malaysia amidst its economic development is the achievement of a critical thinking society. This would enhance and guarantee the success of research and development programs in addition to having other socioeconomic effects. This paper covers the following topics: Vision 2020, Malaysia's goal to reach developed nation…

  19. E-Learning in Supplemental Educational Systems in Taiwan: Present Status and Future Challenges

    Science.gov (United States)

    Zhang, Ke; Hung, Jui-Long

    2009-01-01

    As Taiwan's full-scale e-learning initiatives moved to the seventh year in 2009, the current status and challenges of e-learning development there are yet to be fully understood. Further extending Zhang and Hung's (2006) investigation on e-learning in all universities and colleges in Taiwan, this study investigated the after-school programs (ASPs)…

  20. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges.

    Science.gov (United States)

    Hannan, M A; Abdulla Al Mamun, Md; Hussain, Aini; Basri, Hassan; Begum, R A

    2015-09-01

    In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system. Copyright © 2015 Elsevier Ltd. All rights reserved.