Condition of physical health of pupils of the 7th-8th classes of the comprehensive school

Directory of Open Access Journals (Sweden)

Margarita Mameshina

2016-10-01

Full Text Available Purpose: to investigate the level of physical health of pupils of the 7th-8th classes. Material & Methods: pupils of the 7th-8th classes of the comprehensive school No. 150 of Kharkov participated in the research. The following methods were used: theoretical analysis and generalization of scientific literature, method of express-assessment of physical health, mathematical statistics. Results: the comparative analysis of the obtained data in age aspect and on gender sign is carried out; the general assessment of the level of physical health of pupils of the 7th-8th classes is defined. Conclusions: the insignificant prevalence of indicators of the separate components of health of boys over the data of girls and, generally, the reliable improvement of indicators of pupils with age are established; the "average" level of physical health of pupils of the 7th classes and "below the average" level of pupils of the 8th classes are determined.

4"t"h Annual workshop proceedings of the collaborative project ''Redox phenomena controlling systems'' (7"t"h EC FP CP RECOSY)

International Nuclear Information System (INIS)

Altmaier, Marcus; Kienzler, Bernhard; Duro, Lara; Grive, Mireia; Montoya, Vanessa

2012-01-01

The EURATOM 7"t"h EC Framework Program Collaborative Project REdox phenomena Controlling SYstems (RECOSY) started in April 2008 and extends over 4 years. Although redox is not a new geochemical issue, different questions are still not resolved. For this reason, main objectives of RECOSY project are a) the sound understanding of redox phenomena controlling the long-term release/retention of radionuclides in nuclear waste disposal, b) providing tools to apply the result to Performance Assessment/Safety Case, c) training of next generation and d) documentation and communication of the results. To this aim, the project set up a consortium of 32 Beneficiaries/Contractors and 6 Associated Groups. The consortium includes key European Research Institutes, Universities, National Waste Management Agencies and SMEs, from 13 EURATOM signatory states, Russia, Japan, Korea, USA and one European Joint Research Centre. The ReCosy concept is innovative in the scientific approach to the redox phenomena. It includes i) advanced analytical tools, ii) investigations of processes responsible for redox control (thermodynamically and kinetically controlled processes, surface reactions and microbial processes,..), iii) provision of required data on redox controlling processes, and iv) response to disturbances in disposal systems. The work program is structured along six RTD workpackages (WP1-6). They cover near-field and far field aspects as well as all relevant host-rocks considered in Europe. In WP1, the scientific state-of-the-art and its application to Performance Assessment/Safety Case is documented and regularly updated. WP2 focuses on development of redox determination methods. WP3 focuses on redox response of defined and near-natural systems. WP4 studies the redox reactions of radionuclides. WP5 focuses on Redox processes in radionuclide transport and WP6 deals with redox reactions affecting the spent fuel source-term. Specific workpackages on knowledge management, education and

Comparison of the 6th and 7th editions of the UICC-AJCC TNM classification for esophageal cancer

NARCIS (Netherlands)

K. Talsma (Koen); P. van Hagen (Pieter); B.A. Grotenhuis (Brechtje); E.W. Steyerberg (Ewout); H.W. Tilanus (Hugo); J.J.B. van Lanschot (Jan); B.P.L. Wijnhoven (Bas)

2012-01-01

textabstractBackground. The new 7th edition of the Union for International Cancer Control-American Joint Committee on Cancer (UICC-AJCC) tumor, node, metastasis (TNM) staging system is the ratification of data-driven recommendations from the Worldwide Esophageal Cancer Collaboration database.

Proceedings of the 4th workshop on WENDELSTEIN 7-X

International Nuclear Information System (INIS)

Junker, J.

1991-12-01

The 4th Workshop on WENDELSTEIN 7-x (28.-31.10.1991) treated the following topics: Coil System (optimization; ripple transport; magnetic fields, forces, stresses; analytic stellarator fields) - equilibrium and stability (computations; equilibrium with dissipation; global MHD stability; resistive ballooning modes) - transport and neutral gas (Pfirsch-Schlueter currents and anomalous transport; general solution of the ripple-averaged equation; the EIRENE neutral gas transport codes; application of DEGAS; CX-losses at NBI) - plasma parameters (alpha particle confinement in stellarators; the radical electric field in W 7) - divertor (structure of the magnetic field line diversion in Helias configurations; divertor studies for W 7; sweep coil system; the island divertor; one-dimensional fluid model and investigation of the plasma boundary layer) - engineering (W 7 status of planning; CAD/CAE applications for W 7; structural analysis of the coil system) - reactor (the Helias reactor) - concluding discussion. (AH)

Comparison of Socioeconomic Factors between Surrounding and Non-Surrounding Areas of the Qinghai–Tibet Railway before and after Its Construction

Directory of Open Access Journals (Sweden)

Shicheng Li

2016-08-01

Full Text Available As the world’s highest railway, and the longest highland railway, the Qinghai–Tibet Railway (QTR has been paid considerable attention by researchers. However, most attention has been paid to the ecological and environmental issues affecting it, and sustainable ecological, social, and economic development-related studies of the QTR are rare. In this study, by analyzing the passenger traffic, freight traffic, passenger-kilometers, and freight-kilometers of the QTR for the period 1982–2013 and the transport structure of the Tibetan Plateau (TP for 1990–2013, the evolutionary process of the transport system in the TP following the construction of the QTR has been revealed. Subsequently, by comparing Gross Domestic Product (GDP, population, industrial structure, and urbanization level at the county and 1 km scales between surrounding and non-surrounding areas of the QTR, the differences in socioeconomic performance before and after its construction were detected. The results show that (1 in the TP, the highway-dominated transport system will break up and an integrated and sustainable transport system will form; (2 at the county scale, the annual growth rates of GDP of counties surrounding the QTR were greater than those of non-surrounding counties for the period 2000–2010. At the 1 km scale, following the opening of the completed line, the GDP of surrounding areas had a greater growth rate than before; (3 analysis at the county and 1 km scales indicated that population was not aggregated into the surrounding areas of the QTR in the period 2000–2010; (4 in terms of industrial structure, the proportion of primary industry decreased continuously, while the proportion of secondary and tertiary industries increased overall in the period 1984–2012. The QTR had no obvious impact on changes in the urbanization level of its surrounding areas.

57Fe Moessbauer and magnetization study of the Th7Fe3 and the hydride Th7Fe3H/sub n/

International Nuclear Information System (INIS)

Viccaro, P.J.; Shenoy, G.K.; Dunlap, B.D.; Westlake, D.G.; Malik, S.K.; Wallace, W.E.

1978-01-01

Th 7 Fe 3 is known to be a Pauli paramagnet and to undergo a superconducting transition at 1.86K. Its hydride Th 7 Fe 3 H/sub n/ is shown to possess magnetic ordering. The 57 Fe saturated hyperfine field in the hydride is estimated to be aproximately 20kG. A positive isomer shift of 0.30 +- 0.02 mm/s at 300 K relative to Th 7 Fe 3 would be consistent with an increase in d-like electrons on Fe. Preliminary magnetization results indicate a magnetic moment of about 0.5 μ/sub B/ for the hydride and a transition temperature near 300 K

'HTA for Crisis': sharing experiences during the 7th EBHC Symposium.

Science.gov (United States)

Wladysiuk, Magdalena; Tabor, Anna; Godman, Brian

2013-02-01

The Central and Eastern European Society of Technology Assessment in Health Care was founded in Krakow, Poland in 2003. On October 8th and 9th, the 7th symposium took place titled 'HTA for Crisis'. This meeting was attended by over 250 decision makers, evidence-based specialists, healthcare managers, commercial company personnel and experts. The symposium was principally divided into four main themes: insurance in times of crisis; importance of pricing of health services in times of crisis; managing welfare benefits in times of crisis and Health Technology Assessment in crisis-laden countries. The symposium finished by debating potential ways forward for healthcare systems in times of crisis.

Effectiveness of Motor Skills Development in 5th-7th Grade Girls at Different Modes of Physical Exercises

Directory of Open Access Journals (Sweden)

Olga Ivashchenko

2017-12-01

Full Text Available The objective is to determine the influence of the physical exercises modes on effectiveness of motor skills development in 5th-7th grade girls.  Materials and methods. The study involved 5th grade girls (n = 28, 6th grade girls (n = 28 and 7th grade girls (n = 24. To solve the tasks set, the study relied on general scientific and special research methods, methods of mathematical experiment-planning. Studying the influence of different variants of the educational process structure, namely: the number of repetitions (x1 and the rest intervals (x2 on acquisition of the technique of physical exercises performance, provided for achieving the objective. A full 22 type factorial experiment was conducted. The 5th-7th graders were divided into training groups according to the experiment plan. In total, there were twelve experimental groups organized, four in each class. Results. The analysis of the regression equations shows that the rest interval between repetitions (x2 has the greatest influence on teaching 5th-7th grade girls physical exercises, with the number of repetitions (x1 being of somewhat less significant influence. The relation between these factors (x1x2 has a considerable weight in teaching to “rope climb in two or three sets” and to do a “pullover mount with a swing of one and a push-off with the other leg”. Conclusions. To increase the effectiveness of teaching 5th-7th grade girls physical exercises, the number of repetitions in throwing exercises should be increased to twelve times, and the rest interval reduced to 60 seconds. In the 7th grade, the number of repetitions should be reduced to six times, and the rest interval – to 60 seconds. The rest intervals in the exercises: “pullover mount with a swing of one and a push-off with the other leg” and “rope climbing in two or three sets”, should be reduced to 60 seconds and the number of repetitions – to six.

Peculiarities of Motor Abilities Development in 7th-8th-Graders

Directory of Open Access Journals (Sweden)

Ю. В. Мороз

2015-09-01

Full Text Available The pupose of the research is to define the peculiarities of motor abilities development in children of middle-school age. Research methods: theoretical analysis and collation of scientific and methodological literature; pedagogical testing; methods of mathematical statistics. To determine the effectiveness of realization of the developmental task of the physical education process at the beginning of the school year (in October 2014 and in March 2015, we tested the level of development of physical qualities in the 7th- and 8th-graders, 25 and 25 graders respectively, 13 of which in each class were boys and 12 — girls. Research results. The analysis of the materials shows that during the school year, the boys of the 7th grade showed reliably increased performance in standing long jumps (speed and strength qualities — 1.97%, raising the body from the lying position (strength — 26.46%, bent suspension (strength — 13.45%. The indicators have insignificantly (unreliably increased in the shuttle run 3×10 m (agility — 6.09%, and in body bending from the sitting position (flexibility — 6.25%. The girls showed reliably increased performance in the level of readiness: flexibility — 12%, strength — 12.09%, speed-strength qualities — 5.27%, agility — 7.77%. The analysis of the materials shows that during the school year the 8th-graders (boys reliably increased their physical readiness in speed-strength qualities — 0.8%, strength — 15.7%. The indicators of agility increased unreliably — 2.7%, as well as those of flexibility — 8%. The 8th‑graders (girls reliably improved their indicators in standing long jumps — 2.1%, in bent suspension — 18.8%, raising the body from the lying position in 30 seconds — 17.4%, body bending from the sitting position — 12 5%. The indicators agility improved unreliably — 3.4%. Conclusions. The data obtained are important in solving the pedagogical problems of schoolers’ physical education

Phase study in Sr-Th-P-O system: Structural and thermal investigations of quaternary compounds

International Nuclear Information System (INIS)

Keskar, Meera; Phatak, Rohan; Sali, S.K.; Krishnan, K.; Dahale, N.D.; Kulkarni, N.K.; Kannan, S.

2011-01-01

The sub-solidus phase relations in Sr-Th-P-O quaternary system were determined at 1223 K in air. To confirm the formation and stability of reported phases, ternary and quaternary compounds in Sr-Th-O, Sr-P-O, Th-P-O and Sr-Th-P-O systems were synthesized by solid state reactions of SrCO 3 , ThO 2 and NH 4 H 2 PO 4 in desired molar proportions at 1223 K. A pseudo-ternary phase diagram of SrO-ThO 2 -P 2 O 5 system was drawn on the basis of the phase analysis of various phase mixtures and phase fields were established by powder X-ray diffraction. In the phase diagram, three quaternary compounds SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were identified. When heated in air at 1673 K, these compounds decompose to ThO 2 . Structures of SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were derived from X-ray powder data using the Rietveld refinement method. Thermal expansion behaviors of SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were investigated using high-temperature X-ray diffraction in the temperature range of 298-1273 K.

7th Workshop on Complex Networks

CERN Document Server

Gonçalves, Bruno; Menezes, Ronaldo; Sinatra, Roberta

2016-01-01

The last decades have seen the emergence of Complex Networks as the language with which a wide range of complex phenomena in fields as diverse as Physics, Computer Science, and Medicine (to name just a few) can be properly described and understood. This book provides a view of the state of the art in this dynamic field and covers topics ranging from network controllability, social structure, online behavior, recommendation systems, and network structure. This book includes the peer-reviewed list of works presented at the 7th Workshop on Complex Networks CompleNet 2016 which was hosted by the Université de Bourgogne, France, from March 23-25, 2016. The 28 carefully reviewed and selected contributions in this book address many topics related to complex networks and have been organized in seven major groups: (1) Theory of Complex Networks, (2) Multilayer networks, (3) Controllability of networks, (4) Algorithms for networks, (5) Community detection, (6) Dynamics and spreading phenomena on networks, (7) Applicat...

Benchmarking Advanced Control Algorithms for a Laser Scanner System

DEFF Research Database (Denmark)

Stoustrup, Jakob; Ordys, A.W.; Smillie, I.

1996-01-01

The paper describes tests performed on the laser scanner system toassess feasibility of modern control techniques in achieving a requiredperformance in the trajectory following problem. The two methods tested areQTR H-infinity and Predictive Control. The results are ilustated ona simulation example....

Assessment of an Engineering Technology Outreach Program for 4th-7th Grade Girls

Science.gov (United States)

Dell, Elizabeth M.; Christman, Jeanne; Garrick, Robert D.

2011-01-01

This paper describes a workshop led by female Engineering Technology students, with support from female faculty, to provide an introduction to Engineering Technology to 4th-7th grade girls through a series of interactive laboratory experiments. This outreach program was developed to improve attitudes towards science and engineering in middle…

Physical activity levels and motor skills of 5 th to 7 th grade students ...

African Journals Online (AJOL)

The physical activity (PA) and motor skill levels (MS) (flexibility, balance, speed, sit-up, hand grip strength, standing long jump) were determined for 5th to 7th grade students from central schools in Nigde Province, Turkey according to age and gender and to investigate the relationships. PAL was determined by means of ...

H-infinity Control of Linear Systems with Almost Periodic Inputs

DEFF Research Database (Denmark)

Larsen, Mikael

1996-01-01

In this paper we consider the class of linear, infinitedimensional systems with bounded input and output operators. Wederive and QTR H-infinity type result, formulated for thecase where the input signals are almost periodic in a generalizedsense. Control probelms, for which this result is relevant...

[Review of WHO Expert Committee on Leprosy 8th report, --comparison to 7th report].

Science.gov (United States)

Kitajima, Shinichi; En, Junichiro; Kitajima, Shiori; Barua, Sumana; Goto, Masamichi

2014-03-01

In 2012 the WHO Expert Committee on Leprosy published its 8th report, 14 years after the publication of its 7th report in 1998. This report, the first since the leprosy reduction goal was met in 2000, highlights key points such as improvements in the quality of various services available to patients and the efforts of individuals and societies, in addition to medical progress in diagnosis and treatment. This review will mainly describe the changes made since the 7th report. Some of the main modifications are the deletion of single lesion paucibacillary type, elongated treatment of patients with high bacterial indices, the introduction of promising new drugs, and a shift from reducing the statistical number of patients to a new target for disability prevention.

4{sup th} Annual workshop proceedings of the collaborative project ''Redox phenomena controlling systems'' (7{sup th} EC FP CP RECOSY)

Energy Technology Data Exchange (ETDEWEB)

Altmaier, Marcus; Kienzler, Bernhard; Duro, Lara; Grive, Mireia; Montoya, Vanessa (eds.)

2012-07-01

The EURATOM 7{sup th} EC Framework Program Collaborative Project REdox phenomena Controlling SYstems (RECOSY) started in April 2008 and extends over 4 years. Although redox is not a new geochemical issue, different questions are still not resolved. For this reason, main objectives of RECOSY project are a) the sound understanding of redox phenomena controlling the long-term release/retention of radionuclides in nuclear waste disposal, b) providing tools to apply the result to Performance Assessment/Safety Case, c) training of next generation and d) documentation and communication of the results. To this aim, the project set up a consortium of 32 Beneficiaries/Contractors and 6 Associated Groups. The consortium includes key European Research Institutes, Universities, National Waste Management Agencies and SMEs, from 13 EURATOM signatory states, Russia, Japan, Korea, USA and one European Joint Research Centre. The ReCosy concept is innovative in the scientific approach to the redox phenomena. It includes i) advanced analytical tools, ii) investigations of processes responsible for redox control (thermodynamically and kinetically controlled processes, surface reactions and microbial processes,..), iii) provision of required data on redox controlling processes, and iv) response to disturbances in disposal systems. The work program is structured along six RTD workpackages (WP1-6). They cover near-field and far field aspects as well as all relevant host-rocks considered in Europe. In WP1, the scientific state-of-the-art and its application to Performance Assessment/Safety Case is documented and regularly updated. WP2 focuses on development of redox determination methods. WP3 focuses on redox response of defined and near-natural systems. WP4 studies the redox reactions of radionuclides. WP5 focuses on Redox processes in radionuclide transport and WP6 deals with redox reactions affecting the spent fuel source-term. Specific workpackages on knowledge management, education

JANNAF 17th Propulsion Systems Hazards Subcommittee Meeting. Volume 1

Science.gov (United States)

Cocchiaro, James E. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

1998-01-01

Volume 1, the first of two volumes is a compilation of 16 unclassified/unlimited technical papers presented at the 17th meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Propulsion Systems Hazards Subcommittee (PSHS) held jointly with the 35th Combustion Subcommittee (CS) and Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7 - 11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include projectile and shaped charge jet impact vulnerability of munitions; thermal decomposition and cookoff behavior of energetic materials; damage and hot spot initiation mechanisms with energetic materials; detonation phenomena of solid energetic materials; and hazard classification, insensitive munitions, and propulsion systems safety.

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

Science.gov (United States)

Guimarães, Poliana Macedo; Scavuzzi, Bruna Miglioranza; Stadtlober, Nicole Perugini; Franchi Santos, Lorena Flor da Rosa; Lozovoy, Marcell Alysson Batisti; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Reiche, Edna Maria Vissoci; Maes, Michael; Dichi, Isaias; Simão, Andréa Name Colado

2017-10-01

The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

7th Higgs Hunting 2016

CERN Document Server

2016-01-01

A subject of major importance in fundamental physics is the investigation of the origin of Electroweak Symmetry Breaking. The mechanism of mass generation through the spontaneous breaking of a gauge symmetry is called the Brout-Englert-Higgs mechanism and is associated with the appearance of a physical scalar boson. The discovery announced at CERN on 4th July 2012 by the ATLAS and CMS Collaborations of a boson at a mass close to 125 GeV/c2, compatible with this scalar boson of the Standard Model, the so-called Higgs boson, mainly in γγ, ZZ and WW decay modes, with compatible evidence also found at Fermilab in the bb mode, changed the landscape. This important discovery was acknowledged as decisive for the attribution of the 2013 Nobel Prize in Physics awarded jointly to François Englert and Peter Higgs . This 7th workshop of the "Higgs Hunting" series organized in Paris on August 31 - September 2, 2016 will discuss the developments of LHC run 2 analyses, detailed studies of the new boson and possible de...

Stepping It Up: Walking Behaviors in Children Transitioning from 5th to 7th Grade

Directory of Open Access Journals (Sweden)

Sharon E. Taverno Ross

2018-02-01

Full Text Available The purpose of this study was to (1 describe children’s walking behaviors in 5th to 7th grade and change over time and (2 examine associations between walking behaviors and Walk Score®. Participants consisted of n = 586 students from the Transitions and Activity Changes in Kids (TRACK Study. Children reported any walking behavior (e.g., exercise and transportation over the past five days. Walk Score was calculated based on children’s home address. Descriptive statistics summarized walking behaviors by gender and time, and repeated measure mixed models examined the relationship between walking behaviors and Walk Score. Approximately 46.8% and 19.2% of 5th grade children reported walking for exercise and transportation, respectively, and these percentages declined through 7th grade. Girls reported higher levels of total walking behavior and walking for exercise than boys (p < 0.001. Girls with a higher Walk Score had 63% higher odds of reporting walking for transportation than girls with a lower Walk Score (OR = 1.63, 95% CI = 1.02, 2.62. Walking behaviors among children were infrequent with significant declines over time, and of the nine associations examined with Walk Score, only one was significant. Efforts should prioritize frequent walking behavior and community design to increase children’s physical activity.

Suicidal ideation among students of the 7th, 8th, and 9th grades in the State of Lara, Venezuela: the Global School Health Survey.

Science.gov (United States)

Granero, Ricardo; Poni, Esteban; Poni, Carolin

2008-12-01

Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. The Global School Health Survey is a self-administered survey done on a random probabilistic sample among students of the 7th, 8th, and 9th grades in the Lara State, Venezuela, school period 2003 to 2004. Point prevalence of SI and associated factors were included and the odds (OR) of having SI was calculated given selected factors. Two-thousand seventy (2070) respondents, of which 13.5 % reported having SI in the last 12 months, and in females more than males (14.6% vs. 11.7%). The OR for SI, according to an associated risk factor, were among (a) females: age > or = 14 years (2.2), worries (3.42), loneliness (8.8), ever had sexual intercourse (5.58), alcohol (8.43) and (b) males: having only one or non close friends (3.69), alcohol (12.36), ever had sexual intercourse (2.73). Behavioral risk factors are relatively new in the field of surveillance systems; therefore, results on SI should be cautiously taken into consideration and a wide discussion should be encouraged as we learn how to best use the results for health promotion and disease prevention.

State prisons are covered by ADA, 7th Circuit rules.

Science.gov (United States)

1997-07-25

Prison inmate [name removed] sued the Indiana Department of Corrections, claiming it violated the Americans with Disabilities Act (ADA) by denying him access to education programs, the library, and the dining hall because he is blind. The 7th U.S. Circuit Court of Appeals rejected the district court's decision to dismiss the case based on the grounds that the ADA does not apply to prison inmates. The court held that the Department of Corrections cannot exclude an inmate with a disability from prison programs unless the accommodation caused an undue burden on the system.

7th International Workshop on Natural Computing

CERN Document Server

Hagiya, Masami

2015-01-01

This book highlights recent advances in natural computing, including biology and its theory, bio-inspired computing, computational aesthetics, computational models and theories, computing with natural media, philosophy of natural computing and educational technology. It presents extended versions of the best papers selected from the symposium “7th International Workshop on Natural Computing” (IWNC7), held in Tokyo, Japan, in 2013. The target audience is not limited to researchers working in natural computing but also those active in biological engineering, fine/media art design, aesthetics and philosophy.

The 2001 January 13th M {W}7.7 and February 13th M {W}6.6 El Salvador Earthquakes: Deformation and Stress Triggering

Science.gov (United States)

Hreinsdóttir, S.; Freymueller, J. T.

2001-12-01

On the 13th of January 2001, an M {W} 7.7 normal fault earthquake occurred offshore El Salvador. The earthquake occurred in the subducting Cocos plate and was followed by high seismic activity and several earthquakes exceeding magnitude 5. On the 13th of February, an M {W} 6.6 strike slip earthquake occurred in the overriding Caribbean plate, about 75 km NNW from the epicenter of the large January earthquake. Deformation due to these earthquakes was observed at six continuous CORS GPS stations in Central America. In the M {W} 7.7 earthquake about 10 mm displacement was measured at GPS stations in El Salvador and Honduras. A smaller but significant dispacement was also observed at GPS stations in Nicaragua, more then 200 km from the earthquake's epicenter. In the M {W} 6.6 earthquake 41+/- 1 mm displacement in direction N111oE was measured at the GPS station in San Salvador, El Salvador. Other CORS GPS stations were not affected by that earthquake. A postsesmic signal is detectable at the San Salvador GPS station, strongest right after the earthquake and then decays. On average we see 0.3 +/- 0.1 mm/day of SSW motion of the station in the first twenty days following the earthquake. Using seismic and geodetic data, we calculated Coulomb stress changes following the January 13th, M {W} 7.7 earthquake. Of special interest were six 5.4 earthquake that occurred in the overriding Caribean plate. The location and focal mechanism of these earthquakes correlate with areas of calculated increase in static stress thus indicating stress triggering. The thrust events occurred 2 to 20 days after the M {W} 7.7 earthquake, in increasing distance from the M {W} 7.7 event with time.

7th International Meshing Roundtable '98

Energy Technology Data Exchange (ETDEWEB)

Eldred, T.J.

1998-10-01

The goal of the 7th International Meshing Roundtable is to bring together researchers and developers from industry, academia, and government labs in a stimulating, open environment for the exchange of technical information related to the meshing process. In the past, the Roundtable has enjoyed significant participation from each of these groups from a wide variety of countries.

Proceedings of the Seventh International Conference on Educational Data Mining (EDM) (7th, London, United Kingdom, July 4-7, 2014)

Science.gov (United States)

Stamper, John, Ed.; Pardos, Zachary, Ed.; Mavrikis, Manolis, Ed.; McLaren, Bruce M., Ed.

2014-01-01

The 7th International Conference on Education Data Mining held on July 4th-7th, 2014, at the Institute of Education, London, UK is the leading international forum for high-quality research that mines large data sets in order to answer educational research questions that shed light on the learning process. These data sets may come from the traces…

Autoantibody to Th ribonucleoprotein (nucleolar 7-2 RNA protein particle) in patients with systemic sclerosis

International Nuclear Information System (INIS)

Okano, Y.; Medsger, T.A. Jr.

1990-01-01

We studied sera of 371 consecutive new patients with systemic sclerosis (SSc; scleroderma) who were first evaluated during 1984-1988. All sera were tested for antinuclear antibodies by immunofluorescence staining using HEp-2 cells as substrate. We excluded 219 sera showing dark nucleoli and screened for antibodies to Th in the remaining 152 sera by immunoprecipitation of a 32P-labeled HeLa cell extract. Fifteen (4.0%) of 371 sera were anti-Th+. Anti-Th antibodies were present in 14 (8.4%) of 167 SSc patients with limited cutaneous involvement, in 1 of 167 with diffuse cutaneous involvement, and in 0 of 37 with SSc overlap syndrome. Among 244 controls with other connective tissue diseases, anti-Th was detected in only 3 patients, all having primary Raynaud's phenomenon of less than 2 years duration. In the subgroup with SSc with limited cutaneous involvement, the 14 anti-Th+ patients had a significantly greater frequency of puffy fingers, small bowel involvement, and hypothyroidism, and a significantly lower frequency of arthralgia and/or arthritis. Their cumulative survival rate from the time of onset of symptoms was lower than that for anti-Th- patients (78% versus 91% at 10 years), primarily due to 3 deaths from pulmonary arterial hypertension (2 from primary pulmonary hypertension and 1 from pulmonary hypertension secondary to pulmonary interstitial fibrosis). Serum anti-Th antibodies are present almost exclusively in patients with SSc with limited cutaneous involvement or in those with primary Raynaud's phenomenon whose disease may evolve to SSc with limited cutaneous involvement, and these antibodies may identify those patients who are at greater risk for reduced survival

PREFACE: 7th International Conference on Cooling & Heating Technologies (ICCHT 2014)

Science.gov (United States)

2015-09-01

The Kyoto protocol has initiated a pledge from almost all developing and developed countries to be committed to reducing CO2 emissions. Development of new renewable energy technologies are also of interest in this conference. Greenhouse gases have contributed to global warming and other man-made disasters. Cooling and Heating communities also have responsibilities towards the commitment of reducing the greenhouse gas emissions. In addition, depleting natural resources also act as a threat to the Cooling and Heating industries, causing them to develop highly efficient equipment and innovative technologies. The 1st International Conference on Cooling & Heating Technologies was held in Hanoi Vietnam (Jan. 2005). Whereas the 2nd, 3rd, 4th and 5th ICCHT conferences were held in Dalian, China (Jul. 2006), Tokyo, Japan (Jul. 2007), Jinhae, Korea (Oct. 2008) and Bandung, Indonesia (Dec. 2010) respectively. The 6th International Conference on Cooling & Heating Technologies (ICCTH2012) was held in Xi'an in China on November 9-12, 2012. It is our pleasure to welcome you to the 7th International Conference on Cooling & Heating Technologies (ICCTH2014) on 4th - 6th November 2014 at the Grand Dorsett Subang Hotel, Subang Jaya, Selangor Darul Ehsan, Malaysia The Theme of the Conference is ''Sustainability and Innovation in Heating & Cooling Technologies''. The sub-themes are:- • CO2 Reduction and Low Carbon Technologies • HVAC System and Natural Ventilation • Energy & Alternative Energy • Computational Fluid Dynamics • Low Temperature & Refrigeration Engineering In conjunction with the Conference, an Exhibition will be organized as an integral part of the Conference. Project experiences, product solutions, new applications and state-of-the art information will be highlighted.

Pleural Mesothelioma Surveillance: Validity of Cases from a Tumour Registry

Directory of Open Access Journals (Sweden)

France Labrèche

2012-01-01

Full Text Available BACKGROUND: Pleural mesothelioma is a rare tumour associated with exposure to asbestos fibres. Fewer than than one-quarter of cases registered in the Quebec Tumour Registry (QTR have been compensated as work-related. While establishing a surveillance system, this led to questioning as to whether there has been over-registration of cases that are not authentic pleural mesotheliomas in the QTR.

Proceedings of the 7th simulation science symposium

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

The 7th Simulation Science Symposium was held October 16-17, 2003 at National Institute for Fusion Science, aiming at creating interactions between diversified research areas in the Simulation Science. Researchers from a variety of fields presented recent results and stimulating cross-cutting discussions have been made. (author)

Combat Operations in Mountainous Terrain: Are United States Army Light Infantry Divisions Preparing Properly?

Science.gov (United States)

1987-06-05

Mountain Division, Charles Hauptman, Comeany I. 97th Mountain Infantry Regiment by CPT George Earle, and PFC Hugh Graves (1945), and 10th Mountain...training in this country is believed to depend primarily ’Albert H. Jackman , "The Tenth Mountain Division, A Successful Experiment," The Algine Journal...44-48. Houston, Charles S., Dr. "Altitude Sickness and the Army," 112zard. 2d Qtr 1986: n.p. Jackman , Albert H. "The Tenth Mountain Division, A

European Commission - 7th Framework Programme

International Nuclear Information System (INIS)

Fiorini, G.L.; Vasile, A.

2011-01-01

Highlights: → Core safety optimisation through a set of reactivity feedback coefficients allowing to cope with accidental transients. → Reactor optimisation by exploring innovative options for intermediate circuits and steam generators. → Reactor behaviour under accidental conditions including severe accidents to improve the robustness. → Waste management options having both characteristics of efficiency and economics viability. → Promoting European young human resources skills on sodium fast reactors by means of dedicated workshops and doctoral dissertations. - Abstract: Fast Reactors have a unique capability as sustainable energy source; the closed fuel cycle allows significantly improving the usage of natural resources and the minimisation of volume and heat load of high-level waste. Among the fast reactor systems, the sodium-cooled fast reactor has the most comprehensive technological basis, thanks to the experience gained internationally from operating experimental, prototype and commercial size reactors. The paper summarizes the key characteristics of the four years large Collaborative Project on European Sodium Fast Reactor (CP ESFR - 2009-2012); the CP ESFR follows the 6th FP project named 'Roadmap for a European Innovative SOdium cooled FAst Reactor - EISOFAR' further identifying, organizing and implementing a significant part of the needed R and D effort. The CP ESFR merges the contribution of 25 European partners; it is performed under the aegis of the 7th FP under the Area - Advanced Nuclear Systems with a refund from the European Commission of 5.8 M Euro (11.55 M Euro total budget). It is a key component of the European Sustainable Nuclear Energy Technology Platform (SNE TP) and its Strategic Research Agenda (SRA). The inputs for the project are the key research goals for fourth generation of European sodium cooled fast reactors which can be summarized as follows: an improved safety with in particular the achievement of a robust architecture

7th ECCOMAS Thematic Conference on Smart Structures and Materials

CERN Document Server

Soares, Carlos

2017-01-01

This work was compiled with expanded and reviewed contributions from the 7th ECCOMAS Thematic Conference on Smart Structures and Materials, that was held from 3 to 6 June 2015 at Ponta Delgada, Azores, Portugal. The Conference provided a comprehensive forum for discussing the current state of the art in the field as well as generating inspiration for future ideas specifically on a multidisciplinary level. The scope of the Conference included topics related to the following areas: Fundamentals of smart materials and structures; Modeling/formulation and characterization of smart actuators, sensors and smart material systems; Trends and developments in diverse areas such as material science including composite materials, intelligent hydrogels, interfacial phenomena, phase boundaries and boundary layers of phase boundaries, control, micro- and nano-systems, electronics, etc. to be considered for smart systems; Comparative evaluation of different smart actuators and sensors; Analysis of structural concepts and des...

7th International Conference of Political Economy

OpenAIRE

BEKEN, Gülçin

2016-01-01

Abstract. In this study, the 7th International Conference of Political Economy in İstanbul was evaluated. This year it  was organized by Marmara University Faculty of Economics and Batman University Faculty of Economics and Administrative Sciences with the cooperation of their international supporters all over the world. These conference series are said to be successful to bring all the scholars, academicians, students, and volunteers who are interested in political economy. Starting from 200...

7th International Conference on Physics of Liquid Matter : Modern Problems

CERN Document Server

Chalyi, Alexander

2018-01-01

This book presents a collection of selected lectures discussing current problems in molecular physics and reviews the main cutting-edge advances in condensed and soft matter physics. It offers deep insights and a powerful basis for scientists and engineers to study complicated problems in physics, chemistry, biology, and medicine. The unification of experimental, theoretical, and computational methods allows milestone results to be achieved in areas such as ionic and ionic-electronic liquids, magnetic liquid systems, liquid systems with nanoparticles, structural phase transitions and critical phenomena, and small-angle neutron and X-ray scattering in liquids and liquid systems.   The lectures selected for this book were held at the 7th International Conference “Physics of Liquid Matter: Modern Problems” (PLMMP-2016), 27–31 May in Kiev, Ukraine.

7th IAASS Conference

CERN Document Server

Rongier, Isabelle

2015-01-01

The 7th IAASS Conference, “Space Safety is No Accident” is an invitation to reflect and exchange information on a number of topics in space safety and sustainability of national and international interest. The conference is also a forum to promote mutual understanding, trust and the widest possible international cooperation in such matters. The once exclusive “club” of nations with autonomous sub-orbital and orbital space access capabilities is becoming crowded with fresh and ambitious new entrants. New commercial spaceports are starting operations and others are being built. In the manned spaceflight arena a commercial market is becoming a tangible reality with suborbital spaceflights and government use of commercial services for cargo and crew transportation to orbit. Besides the national ambitions in space, the international cooperation both civil and commercial is also gaining momentum. In the meantime robotic space exploration will accelerate and with it the need to internationally better regulat...

Start-up of a cold loop in a VVER-440, the 7th AER benchmark calculation with HEXTRAN-SMABRE-PORFLO

International Nuclear Information System (INIS)

Hovi, Ville; Taivassalo, Veikko; Haemaelaeinen, Anitta; Raety, Hanna; Syrjaelahti, Elina

2017-01-01

The 7 th dynamic AER benchmark is the first in which three-dimensional thermal hydraulics codes are supposed to be applied. The aim is to get a more precise core inlet temperature profile than the sector temperatures available typically with system codes. The benchmark consists of a start-up of the sixth, isolated loop in a VVER-440 plant. The isolated loop initially contains cold water without boric acid and the start-up leads to a somewhat asymmetrical core power increase due to feedbacks in the core. In this study, the 7 th AER benchmark is calculated with the three-dimensional nodal reactor dynamics code HEXTRAN-SMABRE coupled with the porous computational fluid dynamics code PORFLO. These three codes are developed at VTT. A novel two-way coupled simulation of the 7 th AER benchmark was performed successfully demonstrating the feasibility and advantages of the new reactor analysis framework. The modelling issues for this benchmark are reported and some evaluation against the previously reported comparisons between the system codes is provided.

20th Annual Systems Engineering Conference, Thursday, Volume 4

Science.gov (United States)

2017-10-26

20th Annual Systems Engineering Conference October 23-26, 2017 | Waterford at Springfield | Springfield, VA NDIA.org/systemsengineering...Conference Program SYSTEMS ENGINEERING CONFERENCE 2 Welcome to the NDIA Systems Engineering Conference On behalf of the National Defense Industrial...Association’s Systems Engineering Division, I would like to extend a very warm welcome to the 20th Annual Systems Engineering Conference. Yes, the 20th Annual

Concept Mapping Improves Metacomprehension Accuracy among 7th Graders

Science.gov (United States)

Redford, Joshua S.; Thiede, Keith W.; Wiley, Jennifer; Griffin, Thomas D.

2012-01-01

Two experiments explored concept map construction as a useful intervention to improve metacomprehension accuracy among 7th grade students. In the first experiment, metacomprehension was marginally better for a concept mapping group than for a rereading group. In the second experiment, metacomprehension accuracy was significantly greater for a…

7th iTi Conference in Turbulence

CERN Document Server

Talamelli, Alessandro; Oberlack, Martin; Peinke, Joachim

2017-01-01

This volume collects the edited and reviewed contribution presented in the 7th iTi Conference in Bertinoro, covering fundamental and applied aspects in turbulence. In the spirit of the iTi conference, the volume is produced after the conference so that the authors had the opportunity to incorporate comments and discussions raised during the meeting. In the present book, the contributions have been structured according to the topics: I Theory II Wall bounded flows III Pipe flow IV Modelling V Experiments VII Miscellaneous topics.

9th Annual Systems Engineering Conference: Volume 4 Thursday

Science.gov (United States)

2006-10-26

ISO /IEC 27000 series – Information Security Management System (ISMS) – ISO /IEC 17799:2005 – Code of Practice for Information Security Management...October 2006, Track 2 Standards Organizations Supporting Assurance ISO IEC JTC1TC176 SC1 SC22 Terminology Software Engineering Language, OS SC7...Information Assurance IEEE CS ISO IEC IEEE CS NIST FISMA Projects U.S. Gov’t DoD MIL-STDsPolicy Memos OMG Knowledge Discovery Models OMG 259th Annual

Start-up of a cold loop in a VVER-440, the 7{sup th} AER benchmark calculation with HEXTRAN-SMABRE-PORFLO

Energy Technology Data Exchange (ETDEWEB)

Hovi, Ville; Taivassalo, Veikko; Haemaelaeinen, Anitta; Raety, Hanna; Syrjaelahti, Elina [VTT Technical Research Centre of Finland Ltd, VTT (Finland)

2017-09-15

The 7{sup th} dynamic AER benchmark is the first in which three-dimensional thermal hydraulics codes are supposed to be applied. The aim is to get a more precise core inlet temperature profile than the sector temperatures available typically with system codes. The benchmark consists of a start-up of the sixth, isolated loop in a VVER-440 plant. The isolated loop initially contains cold water without boric acid and the start-up leads to a somewhat asymmetrical core power increase due to feedbacks in the core. In this study, the 7{sup th} AER benchmark is calculated with the three-dimensional nodal reactor dynamics code HEXTRAN-SMABRE coupled with the porous computational fluid dynamics code PORFLO. These three codes are developed at VTT. A novel two-way coupled simulation of the 7{sup th} AER benchmark was performed successfully demonstrating the feasibility and advantages of the new reactor analysis framework. The modelling issues for this benchmark are reported and some evaluation against the previously reported comparisons between the system codes is provided.

Highlights from the 7th European Meeting on Molecular Diagnostics

NARCIS (Netherlands)

Dr. A.J.C. van den Brule, van den; Drs A.J.M. Loonen; Dr. R. Schuurman

2012-01-01

This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics

World health day - 7th april, 2004 "road safety is no accident"

Directory of Open Access Journals (Sweden)

S C Saxena

2004-06-01

Full Text Available In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April. To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They also contributed to spreading the message that such injuries can be prevented. In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April. To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They also contributed to spreading the message that such injuries can be prevented. The accident is defined as unexpected, unplanned event envolving injury, disability or death. The accidents occur in almost all countries. The most alarming fact is that accidents kill more young trained adults between 15-24 years of age group of males, mainly among two wheelers. All sorts of accidents kill more than 5 million

World health day - 7th april, 2004 "road safety is no accident"

Directory of Open Access Journals (Sweden)

S C Saxena

2006-06-01

Full Text Available In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April.To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They alsocontributed to spreading the message that such injuries can be prevented.In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April.To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They alsocontributed to spreading the message that such injuries can be prevented.t '            ■The accident is defined as unexpected, unplanned event envolving injury, disability or death. The accidents occur in almost all countries. The most alarming fact is that accidents kill more young trained adults between 15-24 years of age group of males, mainly among two wheelers. All sorts of accidents

Colorectal cancer and the 7th revision of the TNM staging system: review of changes and suggestions for uniform pathologic reporting.

Science.gov (United States)

Obrocea, F L; Sajin, Maria; Marinescu, Elena Cristina; Stoica, D

2011-01-01

Colorectal cancer (CRC) is a neoplastic disease with a continuously growing incidence in Romania and throughout the world. Although the surgery remains the first line treatment for most of the cases, newly discovered targeted molecular therapies - effective for some patients, but with various side effects and significant financial burden for the national health systems - requires not only stratification of patients in prognostic groups but also evaluation of some non-anatomic factors with major impact on the prognosis and therapeutic strategy. The AJCC/UICC TNM staging system, in his 7th revision, effective for cases diagnosed on or after January 1, 2010, responds to these needs. On the other hand, the role of the pathologist is increasing in terms of workload and amount of information to be included in the pathology report in order to deliver a personalized diagnosis. There are concerns worldwide regarding relevance, validity and completeness of pathologic reporting of CRC in the absence of a uniform reporting format. Therefore, suggestions for a standardized pathology report of CRC are made, based on TNM 7 and recent, up-to-date conclusive published data.

Results of 6th Review Meeting and Perspective of the 7th Review Meeting of the Convention on Nuclear Safety

International Nuclear Information System (INIS)

Lee, Sukho; Kim, Manwoong; You, Jeongwon; Lee, Youngeal

2017-01-01

This paper highlighted the objective and role of the Convention on Nuclear Safety organized by the IAEA. The Convention provides Member States to demonstrate and share how to maintain and improve the level of nuclear safety. The results of the 6 th review meeting were implemented for safety improvements and to prepare for 7 th national report. Seven and a half months before the 7 th Review Meeting, the National Report has submitted on steps and measures taken to implement Convention obligations. The Contracting Parties reviewed each other’s reports, and exchanged written questions, written answers and comments. The discussions in the Country Group sessions were generally good with a lively and frank exchange of information. The Country Groups noted the significant measures taken by Contracting Parties to improve nuclear safety and identified a number of good practices to be shared with all Contracting Parties.

PREFACE: The 7th International Seminar on Geometry, Continua and Microstructures

Science.gov (United States)

Burton, David A.

2007-04-01

It gives me great pleasure to present the proceedings of the 7th International Seminar on Geometry, Continua and Microstructures (GCM 7). The conference took place on 25-27 September 2006 at Lancaster University and the local organisers were Robin Tucker, Tim Walton, myself and Jonathan Gratus of the Lancaster University Mathematical Physics Group. Modern field theories of mechanically and electrically responsive continua have a wealth of interesting applications in physics. Such theories provide effective macroscopic models of complex systems, such as living tissue and material with dynamical defects, that capture macroscopic consequences of microscopic phenomena. GCM is an interdisciplinary conference series, initiated by the Eringen medallist Gérard A Maugin, that brings together physicists and applied mathematicians who have interests in continuum mechanics and differential geometry and who aim to develop new and powerful methods for analysing the behaviour of complex mechanical systems. The earlier conferences in the series were held in Paris, Madrid, Mannheim, Turin, Sinaia and Belgrade. This volume addresses a variety of topics including the physics of saturated porous media, the relationship between growth in living tissue and molecular transport, the mechanics of polymer bonds, the macroscopic properties of damaged elastomers, the mechanics of carbon nanotubes, the geometry of balance systems in Continuum Thermodynamics and wave propagation in the material manifold. I would like to warmly thank the rest of the organising committee and the conference participants for making GCM 7 an enjoyable and rewarding occasion. Photographs may be found at http://www.lancs.ac.uk/depts/spc/conf/gcm7/wss/index.htm David A Burton Editor

20th Annual Systems Engineering Conference. Volume 1, Monday-Tuesday

Science.gov (United States)

2017-10-26

20th Annual Systems Engineering Conference October 23-26, 2017 | Waterford at Springfield | Springfield, VA NDIA.org/systemsengineering...Conference Program SYSTEMS ENGINEERING CONFERENCE 2 Welcome to the NDIA Systems Engineering Conference On behalf of the National Defense Industrial...Association’s Systems Engineering Division, I would like to extend a very warm welcome to the 20th Annual Systems Engineering Conference. Yes, the 20th Annual

7th International Workshop on Parallel Tools for High Performance Computing

CERN Document Server

Gracia, José; Nagel, Wolfgang; Resch, Michael

2014-01-01

Current advances in High Performance Computing (HPC) increasingly impact efficient software development workflows. Programmers for HPC applications need to consider trends such as increased core counts, multiple levels of parallelism, reduced memory per core, and I/O system challenges in order to derive well performing and highly scalable codes. At the same time, the increasing complexity adds further sources of program defects. While novel programming paradigms and advanced system libraries provide solutions for some of these challenges, appropriate supporting tools are indispensable. Such tools aid application developers in debugging, performance analysis, or code optimization and therefore make a major contribution to the development of robust and efficient parallel software. This book introduces a selection of the tools presented and discussed at the 7th International Parallel Tools Workshop, held in Dresden, Germany, September 3-4, 2013.  

The proceedings of the 14th national symposium on atomic physics and nuclear physics and the 7th annual meeting on modern physics

International Nuclear Information System (INIS)

2002-01-01

It is the proceedings of the 14th national symposium on atomic physics and nuclear physics and the 7th annual meeting on modern physics. 27 theses are collected in these proceedings. Many of them are related with nuclear physics

A Rare Case of Simultaneous Acute Bilateral Quadriceps Tendon Rupture and Unilateral Achilles Tendon Rupture

Directory of Open Access Journals (Sweden)

Wei Yee Leong

2013-07-01

Full Text Available Introduction: There have been multiple reported cases of bilateral quadriceps tendon ruptures (QTR in the literature. These injuries frequently associated with delayed diagnosis, which results in delayed surgical treatment. In very unusual cases, bilateral QTRs can be associated with other simultaneous tendon ruptures. Case Report: We present a rare case of bilateral QTR with a simultaneous Achilles Tendon Rupture involving a 31 years old Caucasian man who is a semi-professional body builder taking anabolic steroids. To date bilateral QTR with additional TA rupture has only been reported once in the literature and to our knowledge this is the first reported case of bilateral QTR and simultaneous TA rupture in a young, fit and healthy individual. Conclusion: The diagnosis of bilateral QTR alone can sometimes be challenging and the possibility of even further tendon injuries should be carefully assessed. A delay in diagnosis could result in delay in treatment and potentially worse outcome for the patient. Keywords: Quadriceps tendon rupture; Achilles tendon rupture; Bilateral.

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

DEFF Research Database (Denmark)

Kishimoto, K; Dong, V M; Issazadeh-Navikas, Shohreh

2000-01-01

We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully mismatched cardiac allografts to study the role of T-cell costimulatory pathways in regulating allogeneic T-helper 1 (Th1) versus Th2 responses in vivo. STAT4(-/-) mice have...... impaired Th1 responses, whereas STAT6(-/-) mice do not generate normal Th2 responses. Cardiac allografts from C57BL/6 mice were transplanted into normal wild-type (WT), STAT4(-/-), and STAT6(-/-) BALB/c recipients. STAT4(-/-) and STAT6(-/-) mice rejected their grafts with the same tempo as untreated WT....... Furthermore, there was a similar differential effect of CD28-B7 versus CD154-CD40 blockade in inhibiting immune responses in animals immunized with ovalbumin and complete Freund's adjuvant. These novel data indicate that Th1 and Th2 cells are differentially regulated by CD28-B7 versus CD154-CD40 costimulation...

7th International Conference on Genetic and Evolutionary Computing

CERN Document Server

Krömer, Pavel; Snášel, Václav

2014-01-01

Genetic and Evolutionary Computing This volume of Advances in Intelligent Systems and Computing contains accepted papers presented at ICGEC 2013, the 7th International Conference on Genetic and Evolutionary Computing. The conference this year was technically co-sponsored by The Waseda University in Japan, Kaohsiung University of Applied Science in Taiwan, and VSB-Technical University of Ostrava. ICGEC 2013 was held in Prague, Czech Republic. Prague is one of the most beautiful cities in the world whose magical atmosphere has been shaped over ten centuries. Places of the greatest tourist interest are on the Royal Route running from the Powder Tower through Celetna Street to Old Town Square, then across Charles Bridge through the Lesser Town up to the Hradcany Castle. One should not miss the Jewish Town, and the National Gallery with its fine collection of Czech Gothic art, collection of old European art, and a beautiful collection of French art. The conference was intended as an international forum for the res...

In retrospect. 7th workshop RCA

International Nuclear Information System (INIS)

Knappik, Reinhard

2013-01-01

The 7th Workshop RCA with 27 lectures and 12 poster presentation took place on 10 and 11 June 2013 in Dresden-Rossendorf. The traditional German event brought over 90 participants together from Germany, Austria, France, Switzerland and the Netherlands. This time the workshop put forward a special subject for the first time ('Obstacles and pitfalls when characterising waste packages'). A remarkable range of contributions was presented, which demonstrated the diversity and the problems of this subject matter. Medium to low radioactive waste and their final disposal was discussed. Other topics were the upcoming approval of recycling materials according to paragraph 29 StrlSchV as well as those from NORM (Naturally Occurring Radioactive Materials) regarding radionuclide analytics, the range of matrices to be processed and the practical problems this causes. Although the radiological feature was the central focus, other material aspects were dealt with, above all the approval of recycling materials when nuclear power plants are dismantled, but also in research institutes, which is demanding more and more attention. The lectures by Jessica Riemer (GSI Darmstadt) on the topic 'Waste material management of a research centre with heavy ion accelerators' and Elvira Mesalic (TU Munich) on 'Determining the activity inventory of bituminized old wastes' as well as the poster by Sina Brockmann on the 'Locally resolved analysis or uranium species using a couple systems of CLSM and LIFS' were awarded prizes for being outstanding presentations. (orig.)

Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting The TGFβ/Smad3 pathway.

Science.gov (United States)

Luo, Zhenlong; Ji, Yudong; Tian, Dean; Zhang, Yong; Chang, Sheng; Yang, Chao; Zhou, Hongmin; Chen, Zhonghua Klaus

2018-06-08

Galectin-7 (Gal-7) has been associated with cell proliferation and apoptosis. It is known that Gal-7 antagonises TGFβ-mediated effects in hepatocytes by interacting with Smad3. Previously, we have demonstrated that Gal-7 is related to CD4+ T cells responses; nevertheless, its effect and functional mechanism on CD4+ T cells responses remain unclear. The murine CD4+ T cells were respectively cultured with Gal-7, anti-CD3/CD28 mAbs, or with anti-CD3/CD28 mAbs & Gal-7. The effects of Gal-7 on proliferation and the phenotypic changes in CD4+ T cells were assessed by flow cytometry. The cytokines from CD4+ T cells were analysed by quantitative real-time PCR. Subcellular localisation and expression of Smad3 were determined by immunofluorescence staining and Western blot, respectively. Gal-7 enhanced the proliferation of activated CD4+ T cells in a dose- and β-galactoside-dependent manner. Additionally, Gal-7 treatment did not change the ratio of Th2 cells in activated CD4+ T cells, while it increased the ratio of Th1 cells. Gal-7 also induced activated CD4+ T cells to produce a higher level of IFN-γ and TNF-α and a lower level of IL-10. Moreover, Gal-7 treatment significantly accelerated nuclear export of Smad3 in activated CD4+ T cells. These results revealed a novel role of Gal-7 in promoting proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting the TGFβ/Smad3 pathway. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ottoman Greek Education System and Greek Girls' Schools in Istanbul (19th and 20th Centuries)

Science.gov (United States)

Daglar Macar, Oya

2010-01-01

Modernization efforts in education, which were initiated in the 19th century, can be seen as forerunners of the modernization attempts in the Republic period. In this article, Greek education system in the Ottoman Empire will be discussed and the effects and importance of the changes observed in Greek girls' education in 19th and 20th centuries on…

FIRST-PRINCIPLES PHASE DIAGRAM OF THE Ce-Th SYSTEM

International Nuclear Information System (INIS)

Landa, A; Soderlind, P

2005-01-01

Actinide physics has seen a remarkable focus the last decade or so due to the combination of improved experimental diamond-anvil-cell techniques and the development of fast computers and more advanced theory. All f-electron systems are expected to have multiphase phase diagrams due to the sensitivity of the f-electron band to external influences such as pressure and temperature. For instance, compression of an f-electron metal generally causes the occupation of f-states to change due to the shift of these bands relative to others. This can in some cases, as in the Ce-Th system, cause the crystal to adopt a lower symmetry structure at elevated pressures. Here we study the phase stabilities of Ce, Th, and the Ce-Th system as a function of compression. Theoretically, both Ce and Th metals are rather well described within the DFT, although a proper treatment of the Ce-Th alloys has not yet been presented. In the present paper we revisit this problem by applying the modern theory of random alloys based on the coherent potential approximation (CPA)

7th International Conference on Robotics in Education (RiE)

CERN Document Server

Lepuschitz, Wilfried; Koppensteiner, Gottfried; Balogh, Richard

2017-01-01

This proceedings volume showcases the latest achievements in research and development in Educational Robotics presented at the 7th International Conference on Robotics in Education (RiE) held in Vienna, Austria, during April 14-15, 2016. The book offers a range of methodologies for teaching robotics and presents various educational robotics curricula. It includes dedicated chapters for the design and analysis of learning environments as well as evaluation means for measuring the impact of robotics on the students’ learning success. Moreover, the book presents interesting programming approaches as well as new applications, the latest tools, systems and components for using robotics. The presented applications cover the whole educative range, from elementary school to high school, college, university and beyond, for continuing education and possibly outreach and workforce development. The book provides a framework involving two complementary kinds of contributions: on the one hand on technical aspects and on ...

Evaluation of the 8th AJCC staging system for pathologically versus clinically staged pancreatic adenocarcinoma: A time to revisit a dogma?

Science.gov (United States)

Abdel-Rahman, Omar

2018-02-01

The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic exocrine adenocarcinoma has been released. The current study seeks to assess the 7th and 8th editions among patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been accessed through SEER*Stat program and AJCC 8th edition stages were reconstructed utilizing the collaborative stage descriptions. Kaplan-Meier analysis of overall survival and pancreatic cancer-specific survival analyses (according to both 7th and 8th editions and according to whether pathological or clinical staging were conducted) has been performed. Multivariate analysis of factors affecting pancreatic cancer-specific survival was also conducted through a Cox proportional hazard model. A total of 18  948 patients with pancreatic adenocarcinoma were identified in the period from 2010-2013. Pancreatic cancer-specific survival among pathologically staged patients and according to the 8th edition showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between stage IA and stage IB (P = 0.307) and the comparison between stage IB and stage IIA (P = 0.116). Moreover, P value for stage IA vs IIA was 0.014; while pancreatic cancer-specific survival according to the 7th edition among pathologically staged patients showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between IA and IB (P = 0.072), the comparison between stage IIA and stage IIB (P = 0.065), the comparison between stage IIA and stage III (P = 0.059) and the comparison between IIB and III (P = 0.595). Among clinically staged patients (i.e. those who did not undergo initial radical surgery), the prognostic performance of both 7th and 8th stages for both overall survival and pancreatic cancer-specific survival was

Freedom and Slavery in Early Islamic Time (1st/7th and 2nd/8th centuries

Directory of Open Access Journals (Sweden)

Schneider, Irene

2007-12-01

Full Text Available This article focuses on two topics: the presumption of freedom in the “literary period” (from the 8^th century on and the question of enslavement, sale, bondage or self-dedition of free persons in the “pre-literary period” (7^th and 8^th centuries. Based on the assumption that the legal practice in Late Antiquity influenced the discussions of the early Muslim jurists I will try to reconstruct the legal discourse of the 1^st/7^th and 2^nd/ 8^th centuries and to show that this discourse comprised interesting legal opinions with regard to the sale of children, debt-bondage and the legal position of foundlings. In the legal literature which emerged from the 2^nd/8^th century the jurists did not, as one would expect, deal intensively with the topic. Thus there is, as will be shown, a certain inconsistency between the lively and controversial discourse in the “pre-literary period” on the topic, which will be reconstructed in this article, and the marginalization of the topic in the legal literature afterwards.

Este artículo se centra en dos cuestiones: por un lado, la presunción de libertad en el «período literario» (desde el s. VIII en adelante; y, por otro, la cuestión de la esclavización, venta o servidumbre —voluntaria o no— de personas libres en la «época preliteraria» (ss. VII y VIII. Asumiendo de partida la idea de que la práctica legal en la Antigüedad Tardía influyó en las discusiones de los primeros juristas musulmanes, trataré de reconstruir el discurso legal de los siglos I/VII y II/VIII y de mostrar que ese discurso contenía interesantes opiniones legales en relación a la venta de niños, servidumbre por deudas y la situación legal de los huérfanos. En la literatura legal que emergió desde el s. II/VIII los juristas, al contrario de lo que se hubiese esperado, no trataron estas cuestiones intensamente. Tal y

[A development of Byzantine Christian charities during the 4(th)-7(th) centuries and the birth of the hospital].

Science.gov (United States)

Nam, Sung Hyun

2015-04-01

This study aims to examine the beginning and the development of Christian Charities during the 4(th)-6(th) centuries which would eventually result in the birth of the hospital in modern sense in the first half of the 7(th) century. For this purpose, I looked carefully into various primary sources concerning the early Christian institutions for the poor and the sick. Above all, it's proper to note that the first xenodocheion where hospitality was combined with a systematic caring, is concerned with the Trinitarian debate of the 4(th) century. In 356, Eustathios, one of the leaders of homoiousios group, established xenodocheion to care for the sick and the lepers in Sebaste of Armenia, whereas his opponent Aetios, doctor and leader of the heteroousios party, was reckoned to have combined the medical treatment with his clerical activities. Then, Basil of Caesarea, disciple of Eustathios of Sebaste, also founded in 372 a magnificent benevolent complex named 'Basileias' after its founder. I scrupulously analysed several contemporary materials mentioning the charitable institution of Caesarea which was called alternatively katagogia, ptochotropheion, xenodocheion. John Chrysostome also founded several nosokomeia in Constantinople at the end of the 4(th) century and the beginning of the 5(th) century. Apparently, the contemporary sources mention that doctors existed for these Charities, but there is no sufficient proof that these 'Christian Hospitals,' Basileias or nosokomeia of Constantinople were hospitals in modern sense. Imperial constitutions began to mention ptochotropheion, xenodocheion and orphanotropheion since the second half of the 5(th) century and then some Justinian laws evoked nosokomium, brephotrophia, gerontocomia. These laws reveal that 'Christian Hospitals' were well clarified and deeply rooted in Byzantine society already in these periods. And then, new benevolent institutions emerged in the 6(th) century: nosokomeia for a specific class and

Abnormal increase of cosmic ray on August 7th, 1972

International Nuclear Information System (INIS)

Kodama, Masahiro; Murakami, Kazuaki; Wada, Masami

1974-01-01

The abnormal increase of cosmic ray on Aug. 7th particularly the dependence of its starting time on local time was studied. Cosmic ray increased twice before and after the greatest Forbush decrease in history on August 4th and 7th, 1972. This study is a trial to estimate the anisotropic flow of solar cosmic ray from the time difference time at different places. Further, the past instance of 23 ground-level events were statistically restudied, and the relationship between the time of generation of solar cosmic ray and the time of transmission to the earth was investigated. A list is given regarding the solar cosmic ray of more than 10 9 eV which occurred since the observation had started. The list shows definite three groups. Attention is paid to the transmission time of F type which is considered to have the most simplest transmission mechanism. The dispersion of the transmission time is large regarding flare-starting time and peak wave intensity time, but is small regarding solar wave-starting time, but the dependence on the longitude is systematic. After all, cosmic ray is accelerated after 10 minutes since solar electric wave has started, and arrives at the earth most early in the case of a flare occurred at the root of garden force line toward the earth. In conclusion, the method of studying the difference of the starting time of abnormal increase according to local time may be an effective means for examining in the characteristics of anisotropic flow of solar cosmic ray. (Iwakiri, K.)

The Effects of Using Diorama on 7th Grade Students' Academic Achievement and Science Learning Skills

Science.gov (United States)

Aslan Efe, Hulya

2017-01-01

This study aims to investigate the effects of using diorama on 7th grade students' academic achievement and science learning skills in "human being and environment relation" unit. The participants were 49 (E:25, C:24) 7th grade students studying during 2015-16 academic year in Diyarbakir, Turkey. An achievement test and "science…

7th International Conference on Complex Systems

CERN Document Server

Braha, Dan; Bar-Yam, Yaneer

2012-01-01

The International Conference on Complex Systems (ICCS) creates a unique atmosphere for scientists of all fields, engineers, physicians, executives, and a host of other professionals to explore common themes and applications of complex system science. With this new volume, Unifying Themes in Complex Systems continues to build common ground between the wide-ranging domains of complex system science.

37th National Systems Conference

CERN Document Server

Yadav, Sandeep; Adhikari, Bibhas; Seshadri, Harinipriya; Fulwani, Deepak

2015-01-01

The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 37th National System Conference (NSC 2013). NSC is an annual event of the Systems Society of India (SSI), primarily oriented to strengthen the systems movement and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad are invited to attend the conference. The book presents research articles in the areas of system’s modelling, complex network modelling, cyber security, sustainable systems design, health care systems, socio-economic systems, and clean and green technologies. The book can be used as a tool for further research.

Multi-locus variable number tandem repeat analysis of 7th pandemic Vibrio cholerae

Directory of Open Access Journals (Sweden)

Lam Connie

2012-05-01

Full Text Available Abstract Background Seven pandemics of cholera have been recorded since 1817, with the current and ongoing pandemic affecting almost every continent. Cholera remains endemic in developing countries and is still a significant public health issue. In this study we use multilocus variable number of tandem repeats (VNTRs analysis (MLVA to discriminate between isolates of the 7th pandemic clone of Vibrio cholerae. Results MLVA of six VNTRs selected from previously published data distinguished 66 V. cholerae isolates collected between 1961–1999 into 60 unique MLVA profiles. Only 4 MLVA profiles consisted of more than 2 isolates. The discriminatory power was 0.995. Phylogenetic analysis showed that, except for the closely related profiles, the relationships derived from MLVA profiles were in conflict with that inferred from Single Nucleotide Polymorphism (SNP typing. The six SNP groups share consensus VNTR patterns and two SNP groups contained isolates which differed by only one VNTR locus. Conclusions MLVA is highly discriminatory in differentiating 7th pandemic V. cholerae isolates and MLVA data was most useful in resolving the genetic relationships among isolates within groups previously defined by SNPs. Thus MLVA is best used in conjunction with SNP typing in order to best determine the evolutionary relationships among the 7th pandemic V. cholerae isolates and for longer term epidemiological typing.

Proceedings of 7th Symposium of the Croatian Radiation Protection Association

Energy Technology Data Exchange (ETDEWEB)

Barisic, D; Grahek, Z; Krajcar Bronic, I; Miljanic, S

2008-07-01

The 7th symposium of the Croatian Radiation Protection Association discussed the following topics: general topics; radiation dosimetry and instrumentation; biological effects of radiation; radiation protection in medicine; radioecology and radon. For each subject many investigations, experiments, examples and results are presented. International character of this symposium shows importance of these topics not only in region but world wide.

Proceedings of 7th Symposium of the Croatian Radiation Protection Association

International Nuclear Information System (INIS)

Barisic, D.; Grahek, Z.; Krajcar Bronic, I.; Miljanic, S.

2008-01-01

The 7th symposium of the Croatian Radiation Protection Association discussed the following topics: general topics; radiation dosimetry and instrumentation; biological effects of radiation; radiation protection in medicine; radioecology and radon. For each subject many investigations, experiments, examples and results are presented. International character of this symposium shows importance of these topics not only in region but world wide

18th Asia Pacific Symposium on Intelligent and Evolutionary Systems

CERN Document Server

Ishibuchi, Hisao; Ong, Yew-Soon; Tan, Kay-Chen

2015-01-01

This book contains a collection of the papers accepted in the 18th Asia Pacific Symposium on Intelligent and Evolutionary Systems (IES 2014), which was held in Singapore from 10-12th November 2014. The papers contained in this book demonstrate notable intelligent systems with good analytical and/or empirical results.

Nonlinear H-infinity State Feedback Controllers: Computation of Valid Region

DEFF Research Database (Denmark)

Pedersen, Michael; Møller-Pedersen, J.; Pagh Petersen, M.

1996-01-01

"From a general point of view the state feedback QTR H-infinitysuboptimal control probelm is reasonable well-understood. Inportantproblems remain with regard to a priori information of the size of theneighbourhood where the local state feedback QTR H-infinityproblem is solvable, and with regard t...

7th WACBE World Congress on Bioengineering 2015

CERN Document Server

Lim, Chwee

2015-01-01

This volume publishes the proceedings of the WACBE World Congress on Bioengineering 2015 (WACBE 2015), which was be held in Singapore, from 6 to 8 July 2015. The World Association for Chinese Biomedical Engineers (WACBE) organizes this World Congress biannually. Our past congresses have brought together many biomedical engineers from over the world to share their experiences and views on the future development of biomedical engineering. The 7th WACBE World Congress on Bioengineering 2015 in Singapore continued to offer such a networking platform for all biomedical engineers. Hosted by the Biomedical Engineering Society (Singapore) and the Department of Biomedical Engineering, National University of Singapore, the congress covered all related areas in bioengineering.

Thermodynamic assessment of the HTGR fuel system Th-U-C-O

International Nuclear Information System (INIS)

Ugajin, M.; Shiba, K.

1978-01-01

Carbon monoxide pressures and uranium segregation at 2000 K have been calculated for the three-phase equilibria [(ThU)O 2 + (ThU)C 2 + C] in the Th-U-C-O system. This study is concerned with the thermochemical behavior of (Th, U)O 2 particle fuel for the high-temperature gas-cooled reactor (HTGR). The following two points are considered: (1) Reduction of the in-particle CO pressure of (Th, U)O 2 kernels by doping (Th, U)C 2 to make it an oxygen getter. (2) Prediction of U segregation between (Th, U)O 2 and (Th, U)C 2 , doped in the kernel. (Auth.)

2017 The 7th International Conference on Computer Engineering and Networks

Science.gov (United States)

This conference proceeding is a collection of the papers accepted by the CENet 2017 - the 7th International Conference on Computer Engineering and Networks held on Shanghai from 22-23 July, 2017. This proceeding contains the five parts: Part I focuses on Machine learning (21 papers); Part II Wireless communication (21 papers); Part III Information theory (21 papers), Part IV Cloud science (14 papers) and Part V Data analysis (21 papers). Each part can be used as an excellent reference by industry practitioners, university faculty, and undergraduate as well as graduate students who need to build a knowledge base of the most current advances and state-of-practice in the topics covered by this conference proceedings. This will enable them to produce, maintain, and manage systems with high levels of trustworthiness and complexity Thanks go to the authors for their hard work and dedication as well as the reviewers for ensuring the selection of only the highest quality papers; their efforts made this proceedings possible.

7th China Conference on Wireless Sensor Networks

CERN Document Server

Cui, Li; Guo, Zhongwen

2014-01-01

Advanced Technologies in Ad Hoc and Sensor Networks collects selected papers from the 7th China Conference on Wireless Sensor Networks (CWSN2013) held in Qingdao, October 17-19, 2013. The book features state-of-the-art studies on Sensor Networks in China with the theme of “Advances in wireless sensor networks of China”. The selected works can help promote development of sensor network technology towards interconnectivity, resource sharing, flexibility and high efficiency. Researchers and engineers in the field of sensor networks can benefit from the book. Xue Wang is a professor at Tsinghua University; Li Cui is a professor at Institute of Computing Technology, Chinese Academy of Sciences; Zhongwen Guo is a professor at Ocean University of China.

Idaho National Laboratory Quarterly Performance Analysis

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Lisbeth [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2014-11-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 60 reportable events (23 from the 4th Qtr FY14 and 37 from the prior three reporting quarters) as well as 58 other issue reports (including not reportable events and Significant Category A and B conditions) identified at INL from July 2013 through October 2014. Battelle Energy Alliance (BEA) operates the INL under contract DE AC07 051D14517.

Idaho National Laboratory Quarterly Occurrence Analysis

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-11-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 85 reportable events (18 from the 4th Qtr FY-15 and 67 from the prior three reporting quarters), as well as 25 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (8 from this quarter and 17 from the prior three quarters).

In retrospect. 7th workshop RCA; Nachlese. 7. Workshop RCA. Conference report

Energy Technology Data Exchange (ETDEWEB)

Knappik, Reinhard [Verein fuer Kernverfahrenstechnik und Analytik Rossendorf e.V. (VKTA), Dresden-Rossendorf (Germany). Programmausschuss Workshop RCA

2013-08-15

The 7th Workshop RCA with 27 lectures and 12 poster presentation took place on 10 and 11 June 2013 in Dresden-Rossendorf. The traditional German event brought over 90 participants together from Germany, Austria, France, Switzerland and the Netherlands. This time the workshop put forward a special subject for the first time ('Obstacles and pitfalls when characterising waste packages'). A remarkable range of contributions was presented, which demonstrated the diversity and the problems of this subject matter. Medium to low radioactive waste and their final disposal was discussed. Other topics were the upcoming approval of recycling materials according to paragraph 29 StrlSchV as well as those from NORM (Naturally Occurring Radioactive Materials) regarding radionuclide analytics, the range of matrices to be processed and the practical problems this causes. Although the radiological feature was the central focus, other material aspects were dealt with, above all the approval of recycling materials when nuclear power plants are dismantled, but also in research institutes, which is demanding more and more attention. The lectures by Jessica Riemer (GSI Darmstadt) on the topic 'Waste material management of a research centre with heavy ion accelerators' and Elvira Mesalic (TU Munich) on 'Determining the activity inventory of bituminized old wastes' as well as the poster by Sina Brockmann on the 'Locally resolved analysis or uranium species using a couple systems of CLSM and LIFS' were awarded prizes for being outstanding presentations. (orig.)

7th Annual Systems Biology Symposium: Systems Biology and Engineering

Energy Technology Data Exchange (ETDEWEB)

Galitski, Timothy P.

2008-04-01

Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

Special issue containing papers presented at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (7-11 September 2011) Special issue containing papers presented at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (7-11 September 2011)

Science.gov (United States)

Berk, H. L.

2012-09-01

The topic of the behaviour of energetic alpha particles in magnetic fusion confined plasmas is perhaps the ultimate frontier plasma physics issue that needs to be understood in the quest to achieve controlled power from the fusion reaction in magnetically confined plasmas. The partial pressure of alpha particles in a burning plasma will be ~5-10% of the total pressure and under these conditions the alpha particles may be prone to develop instability through Alfvénic interaction. This may lead, even with moderate alpha particle loss, to a burn quench or severe wall damage. Alternatively, benign Alfvénic signals may allow the vital information to control a fusion burn. The significance of this issue has led to extensive international investigations and a biannual meeting that began in Kyiv in 1989, followed by subsequent meetings in Aspenäs (1991), Trieste (1993), Princeton (1995), JET/Abingdon (1997), Naka (1999), Gothenburg (2001), San Diego (2003), Takayama (2005), Kloster Seeon (2007) and Kyiv (2009). The meeting was initially entitled 'Alpha Particles in Fusion Research' and then was changed during the 1997 meeting to 'Energetic Particles in Magnetic Confinement Systems' in appreciation of the need to study the significance of the electron runaway, which can lead to the production of energetic electrons with energies that can even exceed the energy produced by fusion products. This special issue presents some of the mature interesting work that was reported at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems, which was held in Austin, Texas, USA (7-11 September 2011). This meeting immediately followed a related meeting, the 5th IAEA Technical Meeting on Theory of Plasma Wave Instabilities (5-7 September 2011). The meetings shared one day (7 September 2011) with presentations relevant to both groups. The presentations from most of the participants, as well as some preliminary versions of papers, are available at the

27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes

Energy Technology Data Exchange (ETDEWEB)

Kim, Sun-Mi, E-mail: lala1647@hanmail.net [Department of Pharmacology, Pusan National University, School of Medicine, Yangsan, Gyeongnam 626-870 (Korea, Republic of); Kim, Bo-Young, E-mail: kimboyoung@pusan.ac.kr [Department of Pharmacology, Pusan National University, School of Medicine, Yangsan, Gyeongnam 626-870 (Korea, Republic of); Lee, Sae-A, E-mail: saeah486@nate.com [Department of Pharmacology, Pusan National University, School of Medicine, Yangsan, Gyeongnam 626-870 (Korea, Republic of); Eo, Seong-Kug, E-mail: vetvirus@chonbuk.ac.kr [Laboratory of Microbiology, College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Yun, Yungdae, E-mail: yunyung@ewha.ac.kr [Department of Life Science, Ewha Womans University, Seoul 120-750 (Korea, Republic of); Kim, Chi-Dae, E-mail: chidkim@pusan.ac.kr [Department of Pharmacology, Pusan National University, School of Medicine, Yangsan, Gyeongnam 626-870 (Korea, Republic of); Kim, Koanhoi, E-mail: koanhoi@pusan.ac.kr [Department of Pharmacology, Pusan National University, School of Medicine, Yangsan, Gyeongnam 626-870 (Korea, Republic of)

2014-02-01

Th1 lymphocytes are predominant in atherosclerotic lesions. However, mechanisms involved in the Th1 predominance are unknown. We have investigated the possibility of Th1 lymphocyte recruitment in a cholesterol-rich milieu. A high cholesterol diet resulted in enhanced expression of CCR5 ligands, including CCL3 and CCL4, but not of proatherogenic CXCR3 ligands, in atherosclerotic arteries of ApoE{sup −/−} mice. 27-Hydroxycholesterol and 7α-hydroxycholesterol, cholesterol oxides (oxysterols) detected in abundance in atherosclerotic lesions, greatly induced the transcription of CCL3 and CCL4 genes in addition to enhancing secretion of corresponding proteins by THP-1 monocytic cells. However, an identical or even higher concentration of cholesterol, 7β-hydroxycholesterol, and 7-ketocholsterol did not influence expression of these chemokines. Conditioned media containing the CCR5 ligands secreted from THP-1 cells induced migration of Jurkat T cells expressing CCR5, a characteristic chemokine receptor of Th1 cells, but not of Jurkat T cells that do not express CCR5. The migration of CCR5-expressing Jurkat T cells was abrogated in the presence of a CCR5-neutralizing antibody. 27-Hydroxycholesterol and 7α-hydroxycholesterol enhanced phosphorylation of Akt. Pharmacological inhibitors of phosphoinositide-3-kinase/Akt pathways blocked transcription as well as secretion of CCL3 and CCL4 in conjunction with attenuated migration of CCR5-expressing Jurkat T cells. This is the first report on the involvement of cholesterol oxides in migration of distinct subtype of T cells. We propose that 27-hydroxycholesterol and 7α-hydroxycholesterol can trigger a sequence of events that leads to recruitment of Th1 lymphocytes and phosphoinositide-3-kinase/Akt pathways play a major role in the process. - Graphical abstract: Th1 lymphocytes are predominant in atherosclerotic lesions. However, mechanisms involved in the Th1 predominance are unknown. We have investigated the possibility of

27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes

International Nuclear Information System (INIS)

Kim, Sun-Mi; Kim, Bo-Young; Lee, Sae-A; Eo, Seong-Kug; Yun, Yungdae; Kim, Chi-Dae; Kim, Koanhoi

2014-01-01

Th1 lymphocytes are predominant in atherosclerotic lesions. However, mechanisms involved in the Th1 predominance are unknown. We have investigated the possibility of Th1 lymphocyte recruitment in a cholesterol-rich milieu. A high cholesterol diet resulted in enhanced expression of CCR5 ligands, including CCL3 and CCL4, but not of proatherogenic CXCR3 ligands, in atherosclerotic arteries of ApoE −/− mice. 27-Hydroxycholesterol and 7α-hydroxycholesterol, cholesterol oxides (oxysterols) detected in abundance in atherosclerotic lesions, greatly induced the transcription of CCL3 and CCL4 genes in addition to enhancing secretion of corresponding proteins by THP-1 monocytic cells. However, an identical or even higher concentration of cholesterol, 7β-hydroxycholesterol, and 7-ketocholsterol did not influence expression of these chemokines. Conditioned media containing the CCR5 ligands secreted from THP-1 cells induced migration of Jurkat T cells expressing CCR5, a characteristic chemokine receptor of Th1 cells, but not of Jurkat T cells that do not express CCR5. The migration of CCR5-expressing Jurkat T cells was abrogated in the presence of a CCR5-neutralizing antibody. 27-Hydroxycholesterol and 7α-hydroxycholesterol enhanced phosphorylation of Akt. Pharmacological inhibitors of phosphoinositide-3-kinase/Akt pathways blocked transcription as well as secretion of CCL3 and CCL4 in conjunction with attenuated migration of CCR5-expressing Jurkat T cells. This is the first report on the involvement of cholesterol oxides in migration of distinct subtype of T cells. We propose that 27-hydroxycholesterol and 7α-hydroxycholesterol can trigger a sequence of events that leads to recruitment of Th1 lymphocytes and phosphoinositide-3-kinase/Akt pathways play a major role in the process. - Graphical abstract: Th1 lymphocytes are predominant in atherosclerotic lesions. However, mechanisms involved in the Th1 predominance are unknown. We have investigated the possibility of Th1

6th Conference on Design and Modeling of Mechanical Systems

CERN Document Server

Fakhfakh, Tahar; Daly, Hachmi; Aifaoui, Nizar; Chaari, Fakher

2015-01-01

This book offers a collection of original peer-reviewed contributions presented at the 6th International Congress on Design and Modeling of Mechanical Systems (CMSM’2015), held in Hammamet, Tunisia, from the 23rd to the 25th of March 2015. It reports on both recent research findings and innovative industrial applications in the fields of mechatronics and robotics, dynamics of mechanical systems, fluid structure interaction and vibroacoustics, modeling and analysis of materials and structures, and design and manufacturing of mechanical systems. Since its first edition in 2005, the CMSM Congress has been held every two years with the aim of bringing together specialists from universities and industry to present the state-of-the-art in research and applications, discuss the most recent findings and exchange and develop expertise in the field of design and modeling of mechanical systems. The CMSM Congress is jointly organized by three Tunisian research laboratories: the Mechanical Engineering Laboratory of th...

Isothermal equilibrium pressures of Y-Th alloy-H2 system

International Nuclear Information System (INIS)

Tanase, M.; Fisher, P.W.

1985-01-01

Isothermal equilibrium pressures of the Y 4 Th (3:2 by weight) alloy-H 2 system were measured as a function of atomic composition [H]/[Y + Th] in the temperature range 580-1160 K. The isotherms have two plateaux in the pressure range 10 -2 -10 3 Pa. The first plateau region is attributed to the formation of YH 2 , and the equilibrium pressure P in pascals was found to be log P = 12.36 - 11300/T where T is in kelvins. The second plateau is attributed to the formation of ThH 2 , and the equilibrium pressure was found to be log P = 10.66 - 6891/T. In low atomic composition region the system obeys Sieverts' law. (Auth.)

Teaching systems thinking to 4th and 5th graders using Environmental Dashboard display technology.

Science.gov (United States)

Clark, Shane; Petersen, John E; Frantz, Cindy M; Roose, Deborah; Ginn, Joel; Rosenberg Daneri, Daniel

2017-01-01

Tackling complex environmental challenges requires the capacity to understand how relationships and interactions between parts result in dynamic behavior of whole systems. There has been convincing research that these "systems thinking" skills can be learned. However, there is little research on methods for teaching these skills to children or assessing their impact. The Environmental Dashboard is a technology that uses "sociotechnical" feedback-information feedback designed to affect thought and behavior. Environmental Dashboard (ED) combines real-time information on community resource use with images and words that reflect pro-environmental actions of community members. Prior research indicates that ED supports the development of systems thinking in adults. To assess its impact on children, the technology was installed in a primary school and children were passively exposed to ED displays. This resulted in no measurable impact on systems thinking skills. The next stage of this research examined the impact of actively integrating ED into lessons on electricity in 4th and 5th grade. This active integration enhanced both content-related systems thinking skills and content retention.

Application of the AJCC 7th edition carcinoma of the eyelid staging system: a medical center pathology based, 15-year review

Directory of Open Access Journals (Sweden)

Crawford CM

2011-11-01

Full Text Available Courtney Crawford1, Colby Fernelius2, Paula Young1, Stephen Groo2, Darryl Ainbinder21Blanchfield Army Hospital, Fort Campbell, KY, USA; 2Madigan Army Medical Center, Fort Lewis, WA, USAContext: The purpose of this study was to conduct a quality improvement (QI, applied practical review of the American Joint Committee on Cancer (AJCC 7th edition, Carcinoma of the Eyelid staging system. AJCC utilizes a primary tumor, lymph node, metastasis (pTNM cancer staging approach.Objective: We wanted to determine if the AJCC pTNM carcinoma staging system identified patients with highly aggressive carcinoma of the eyelid. We also wanted to determine if there were any unexpected issues in its practical application. Design: We conducted a 15-year, consecutive, retrospective review of all cases of excisional biopsy for carcinoma of the eyelid. We reviewed the original histopathology slides and complete pathology records for each case.Results: Over a 15-year review period, 52 cases of excisional biopsy for carcinoma of the eyelid were identified. The average age of the study population was 72 years. Nodular well-differentiated basal cell carcinoma (BCC was the predominant histology for 85% of cases. Morpheaform/metatypical BCC was the next dominant at 9%. Squamous cell carcinoma and sebaceous carcinoma followed at 4% and 2%, respectively. We were able to assign clear staging to 50 of the 52 cases with the available pathology data. The stage results were as follows: stage 1A 72%, stage 1B 22%, stage II 4%, stage III 2%, with no cases of stage IV metastatic disease.Conclusions: The 7th edition AJCC Carcinoma of the Eyelid chapter proved to be a practical tool for carcinoma staging of the eyelid. The largest tumor dimension remains an effective predictive factor. High-grade pathologic prognostic factors such as tumor necrosis or perineural spread had a 100% association with a final stage of II or greater. Concordance and compliance was 100% for the recommended site

Idaho National Laboratory Quarterly Performance Analysis - 1st Quarter FY2015

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-03-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (27 from the 1St Qtr FY-15 and 46 from the prior three reporting quarters), as well as 38 other issue reports (including nine not reportable events and Significant Category A and B conditions reported during the1st Qtr FY-15) identified at INL during the past 12 months.

Smart energy systems and 4th generation district heating

DEFF Research Database (Denmark)

Lund, Henrik; Duic, Neven; Østergaard, Poul Alberg

2016-01-01

scientific understanding on how we can design and implement a suitable and least-cost transformation into a sustainable energy future. The concept of Smart Energy Systems emphasizes the importance of being coherent and cross-sectoral when the best solutions are to be found and how this also calls......This editorial gives an introduction to the important relationship between Smart Energy Systems and 4th Generation District Heating and presents a number of selected papers from the 1st International Conference on the topic. All of the papers elaborate on or otherwise contribute to the theoretical...... for the active inclusion of the heating and cooling sectors. The concept of 4th Generation District Heating emphasizes that district heating and cooling are both important elements but also technologies that have to be developed further into a 4th generation version to be able to fulfil their roles in future...

7th Young Researcher Meeting

International Nuclear Information System (INIS)

2017-01-01

Young Researcher Meeting, Torino 2016 F Agostini, C Antolini, A Avella, G Cattani, R Cuccaro, A Cultrera, M Di Stefano, G Fragione, L Lolli, M Migliaccio, L Pagnanini, E Pessana, F Piacentini, D Pietrobon, E Pusceddu, R Romeo, M Serra, E Simonetto, F Stellato Preface The Young Researcher Meeting (www.yrmr.it) has been established as a forum for students, postdoctoral fellows and young researchers determined to play a proactive role in the scientific progress. Since 2009 we run itinerant yearly meetings to discuss the most recent developments and achievements in Physics, as we are firmly convinced that sharing expertise and experience is the foundation of the research activity. One of the main purposes of the conference is actually to create an international network of young researchers, both experimentalists and theoreticians, and fruitful collaborations across the different branches of Physics. The format we chose is an informal meeting primarily aimed at students and researchers at the beginning of their scientific career, who are encouraged to present their work in brief presentations able to provide genuine engagement of the audience and cross-pollination of ideas. The 7 th edition of the Young Researcher Meeting was held at the Istituto Nazionale di Ricerca Metrologica (INRiM) in Turin, the Italian National Metrology Institute responsible for the national standards of the International System of Units. The conference took place from Monday 24 th to Wednesday 26 th October 2016. This edition gathered 120 participants belonging to universities and research centres from all over the world. The plenary talk sessions covered several areas of pure and applied Physics, and they were complemented by an extremely rich and interactive poster session, which was also extended to the coffee breaks. The programme included a “poster and wine” session on the first evening, a guided tour at the Turin Astrophysical Observatory and a very enjoyable and friendly conference

JANNAF 18th Propulsion Systems Hazards Subcommittee Meeting. Volume 1

Science.gov (United States)

Cocchiaro, James E. (Editor); Gannaway, Mary T. (Editor)

1999-01-01

This volume, the first of two volumes is a compilation of 18 unclassified/unlimited-distribution technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 18th Propulsion Systems Hazards Subcommittee (PSHS) meeting held jointly with the 36th Combustion Subcommittee (CS) and 24th Airbreathing Propulsion Subcommittee (APS) meetings. The meeting was held 18-21 October 1999 at NASA Kennedy Space Center and The DoubleTree Oceanfront Hotel, Cocoa Beach, Florida. Topics covered at the PSHS meeting include: shaped charge jet and kinetic energy penetrator impact vulnerability of gun propellants; thermal decomposition and cookoff behavior of energetic materials; violent reaction; detonation phenomena of solid energetic materials subjected to shock and impact stimuli; and hazard classification, insensitive munitions, and propulsion systems safety.

7th International Fermi Symposium

Science.gov (United States)

2017-10-01

especially encourage guest investigators worldwide to participate in this symposium to share results and to learn about upcoming opportunities. This meeting will focus on the new scientific investigations and results enabled by Fermi, the mission and instrument characteristics, future opportunities, coordinated observations and analysis techniques. In particular, we also encourage discussion of future prospects/science with Fermi in preparation for the upcoming NASA senior review. Details on the 7th International Fermi Symposium can be found here: https://events.mpe.mpg.de/Fermi2017

Effects of the opening of the Qinghai-Tibet Railway on municipal solid waste management generation in Lhasa.

Science.gov (United States)

Ding, Xu-Tong; Wang, Ji-Hua

2018-03-01

Lhasa, the capital of Tibet, is located on the Tibetan Plateau. Accelerated economic development and flourishing tourism resulting from the opening of the Qinghai-Tibet Railway (QTR) have increased solid waste generation and contamination in recent years. Using data from Lhasa Statistical Yearbooks and previous studies, this study estimates the future population of permanent residents and tourists using the least squares method to extrapolate the population from 2015-2025, and evaluates the effects of the QTR on municipal solid waste (MSW) generation in Lhasa and estimates future MSW generation. There were approximately 1.35 million tourists in 2008 when the QTR had been operating for 2 years and MSW generation was approximately 470 tons per day. The amount of MSW generated increased dramatically with time after opening the QTR. This study estimates that MSW generation will reach 962 tons per day in 2025. Due to the existence of the QTR, increasing numbers of people are traveling to Lhasa, and tourism has driven the development of the local economy. During the studies, the proportion of MSW produced by tourists increased from 2.99% to 20.06%, and it is estimated that it will increase to 33.49% in 2025. If the current trend continues, Lhasa will face significant challenges from garbage disposal. This study analyzes the current situation of urban garbage treatment in Lhasa, and it suggests several options for improvement to MSW generation, transportation equipment, disposal, and resource recycling.

Proceedings of 7th short conference on neutron radiography

International Nuclear Information System (INIS)

Hiraoka, Eiichi; Katsurayama, Kousuke; Tsujimoto, Tadashi

1986-10-01

The first short period conference on neutron radiography was held in 1970, and now the 7th meeting was held. The works to develop neutron radiography in Japan are as active as those in western countries, and the research is in progress by using neutrons from reactors, radioisotopes and accelerators in order to achieve the technology of high standard. In this conference, 26 papers and six comments were presented, and the themes covered the equipment for radiography, the practical application, and the related research. The second World Conference on Neutron Radiography will be held in Paris in June, 1986, and the further promotion of the spread of neutron radiography can be expected. The proceedings of the conference is published with the hope that joint effort and information exchange are further enhanced in coming years to develop the neutron radiography in Japan. The neutron radiography using the Kinki University reactor, the Rikkyo Triga-2 reactor, the Musashi reactor, the Kyoto research reactor, a 3MV Van de Graaff accelerator in Toyota, a subcompact cyclotron in Sumitomo, a baby cyclotron-dual collimator in National Space Development Agency and so on, Cf-252 based thermal neutron radiography, CT with Sb-124/Be neutrons, pulse power neutron source, imaging converters, neutron radiographic image processing, computed tomography using neutron television systems and others are reported. (Kako, I.)

Contributions to the 7th International Conference on plasma surface interactions in controlled fusion devices

International Nuclear Information System (INIS)

1986-01-01

The report contains three papers presented in the 7th International Conference on plasma surface interactions in controlled fusion devices held in Princeton (USA) 5-9 May 1986, all referred to the FT Tokamak

*Abstracts - 7th IN-CAM Research Symposium, Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety - November 2012.

Science.gov (United States)

Boon, Heather; Verhoef, Marja J

2012-10-23

Abstract The following are abstracts of oral and poster presentations given at the 7th IN-CAM Research Symposium - Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety, and the 4th HomeoNet Research Forum, a pre-Symposium event. The IN-CAM Research Symposium was held November 2 to 4, 2012 at the Leslie Dan Faculty of Pharmacy, University of Toronto, in Toronto, Ontario, Canada. For more information, please visit: www.incamresearch.ca.

NDE Conference on Civil Engineering : a joint conference of the 7th Structural Materials Technology Conference (SMT) and the 6th International Symposium on Nondestructive Testing in Civil Engineering (NDT-CE)

Science.gov (United States)

2007-01-01

The 2006 NDE conference on Civil Engineering was held in St. Louis, MO on August 14 18, 2006. The conference combined the 7th Structural Materials Technology Conference (SMT) along with the 6th International Symposium on Nondestructive Testing in...

The Contribution of Morphological Knowledge to 7th Grade Students' Reading Comprehension Performance

Science.gov (United States)

Mokhtari, Kouider; Neel, Joanna; Matatall, Abbey; Richards, Andrea

2015-01-01

In this study, we examined the role of morphology, an important yet largely understudied source of difficulty, in reading ability among 7th grade students in one junior high school in the southwestern United States. We sought to find out how much variance in reading ability is accounted for by these students' morphological knowledge, and whether…

The 7 th framework program of the EU

International Nuclear Information System (INIS)

Gonzalez, E. M.; Serrano, J. A.

2007-01-01

The framework Program is the principal community initiative for fostering and supporting R and D in the European Union. its main goal is to improve competitiveness by fundamentally financing research, technological development, demonstration and innovation activities through transnational collaboration between research institutes and firms belong to both the European Union countries and States affiliated as third countries. In addition, it provides financial support to enhancement and coordination of European research infrastructures, promotion and training of research personnel, basic research and, particularly as of the current 7th Framework Program, coordination of national R and D programs and impllementation of European technology platforms (PTEs), which have been conveived to promote strategic research agendas in key sectors with the cooperation of all the involved players. In the wake of the PTEs, different national platforms have been implemented at the national level which are very active in different sectors. (Authors)

Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.

Science.gov (United States)

Barkhordarian, Andre; Thames, April D; Du, Angela M; Jan, Allison L; Nahcivan, Melissa; Nguyen, Mia T; Sama, Nateli; Chiappelli, Francesco

2015-01-01

Viral cellular immune surveillance is a dynamic and fluid system that is driven by finely regulated cellular processes including cytokines and other factors locally in the microenvironment and systemically throughout the body. It is questionable as to what extent the central nervous system (CNS) is an immune-privileged organ protected by the blood-brain barrier (BBB). Recent evidence suggests converging pathways through which viral infection, and its associated immune surveillance processes, may alter the integrity of the blood-brain barrier, and lead to inflammation, swelling of the brain parenchyma and associated neurological syndromes. Here, we expand upon the recent "gateway theory", by which viral infection and other immune activation states may disrupt the specialized tight junctions of the BBB endothelium making it permeable to immune cells and factors. The model we outline here builds upon the proposition that this process may actually be initiated by cytokines of the IL-17 family, and recognizing the intimate balance between TH17 and TH9 cytokine profiles systemically. We argue that immune surveillance events, in response to viruses such as the Human Immunodeficiency Virus (HIV), cause a TH17/TH9 induced gateway through blood brain barrier, and thus lead to characteristic neuroimmune pathology. It is possible and even probable that the novel TH17/TH9 induced gateway, which we describe here, opens as a consequence of any state of immune activation and sustained chronic inflammation, whether associated with viral infection or any other cause of peripheral or central neuroinflammation. This view could lead to new, timely and critical patient-centered therapies for patients with neuroimmune pathologies across a variety of etiologies. BBB - blood brain barrier, BDV - Borna disease virus, CARD - caspase activation and recruitment domains, CD - clusters of differentiation, CNS - central nervous system, DAMP - damage-associated molecular patterns, DENV - Dengue

7th International Conference on Complex Systems Design & Management

CERN Document Server

Goubault, Eric; Krob, Daniel; Stephan, François

2017-01-01

This book contains all refereed papers that were accepted to the seventh edition of the international conference « Complex Systems Design & Management Paris» (CSD&M Paris 2016) which took place in Paris (France) on the December 13-14, 2016 These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (aeronautic & aerospace, defense & security, electronics & robotics, energy & environment, healthcare & welfare services, software & e-services, transportation), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, system is modeling tools) and system types (artificial ecosystems, embedded systems, software & information systems, systems of systems, transportation systems). The CSD&M Paris 2016 conference is organized under the guidance of the CESAMES non-profit orga...

7th International k0-Users' Workshop

International Nuclear Information System (INIS)

Borut Smodis

2018-01-01

Complete text of publication follows. The k 0 method of neutron activation analysis (k 0 -NAA) has become a well-established analytical tool for elemental analysis of various samples since its introduction in mid-1970s. To strengthen its development, applications and use, a series of regular workshops dedicated to this particular analytical method has been introduced twenty-five years ago, held in Astene, Belgium (1992); Ljubljana, Slovenia (1996); Bruges, Belgium (2001); Funchal, Portugal (2005); Belo Horizonte, Brazil (2009) and Budapest, Hungary (2013). The 7th k 0 -Users' Workshop was held at Hotel Novotel Montreal Centre, Canada, 3-8 September 2017. The meeting was organized by Polytechnique Montreal in cooperation with the International Atomic Energy Agency. Twenty-seven participants from 16 different countries (Australia, Austria, Belgium, Brazil, Canada, Czech Republic, Egypt, Germany, Hungary, Italy, Jamaica, Peru, Slovenia, the Netherlands, Turkey, Vietnam) from all five continents discussed the latest developments and applications of k 0 -NAA. Thirty-three papers were presented in the following sessions: Fundamentals of k 0 -NAA, Nuclear Data, Neutron Flux Parameters, k 0 -NAA Methodology, Validation of k 0 -NAA, Facilities, Automatization, and k 0 -NAA Methodology and PGAA. The talks included presentations by two Keynote Speakers and one Honorary Speaker. During the workshop, scientific visits were paid to the SLOWPOKE NAA Laboratory and Thermal Hydraulics Laboratory of the Polytechnique Montreal. The upcoming 12 papers in this issue of the Journal of Radioanalytical and Nuclear Chemistry were selected to be published from the workshop. The next, 8th k 0 -Users' Workshop is expected to be held in Ljubljana, Slovenia in 2021.

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 3, Sessions 12-16

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 3, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, ad the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected abstracts have been indexed separately for inclusion in the Energy Science and Technology Database.

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

International Nuclear Information System (INIS)

Block, R.C.; Feiner, F.

1995-09-01

This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 2, Sessions 6-11

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 2, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Six calendar systems in the European history from 18^{th} to 20^{th} Century

Science.gov (United States)

Theodossiou, Efstratios; Manimanis, Vassilios N.; Dimitrijević, Milan S.

The following calendar systems, introduced in Europe from 18^{th} to 20^{th} century, which were in use for a shorter or longer period by a larger or smaller community, were reviewed and discussed: The French Revolutionary Calendar, the Theosebic calendar invented by Theophilos Kairis, the Revolutionary Calendar of the Soviet Union (or 'Bolshevik calendar'), the Fascist calendar in Italy and the calendar of the Metaxas dictatorship in Greece before World War II. Also the unique of them, which is still in use, the New Rectified Julian calendar of the Orthodox Church, adopted according to proposition of Milutin Milanković on the Congress of Orthodox Churches in 1923 in Constantinople, is presented and discussed. At the end, difficulties to introduce a new calendar are discussed as well.

7th Italian Forum on Ambient Assisted Living

CERN Document Server

Marletta, Vincenzo; Monteriù, Andrea; Siciliano, Pietro

2017-01-01

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. The coverage is wide ranging, with sections on assistive devices, elderly people monitoring, home rehabilitation, ICT solutions for AAL, living with chronic conditions, robotic assistance for the elderly, sensing technologies for AAL, and smart housing. The book comprises a selection of the best papers presented at the 7th Italian Forum on Ambient Assisted Living (ForitAAL 2016), which was held in Pisa, Italy, in June 2016 and brought together end users, technology teams, and policy makers to develop a consensus on how to improve provision for elderly and impaired people. Readers will find that the expert contributions offer clear insights into the ways in which the most recent exciti ng advances may be expected to assist in addressing the needs of the elderly and those with chronic conditions.

5th International Symposium on Positive Systems

CERN Document Server

Farina, Lorenzo; Setola, Roberto; Germani, Alfredo

2017-01-01

This book presents high-quality original contributions on positive systems, including topics such as: monotone dynamical systems in mathematical biology and game theory; mathematical developments for networked systems in biology, chemistry and the social sciences; linear and nonlinear positive operators; dynamical analysis, observation and control of positive distributed parameter systems; stochastic realization theory; biological systems with positive variables and positive controls; iterated function systems; nonnegative dynamic processes; and dimensioning problems for collaborative systems. The book comprises a selection of the best papers presented at the POSTA 2016, the 5th International Symposium on Positive Systems, which was held in Rome, Italy, in September 2016. This conference series represents a targeted response to the growing need for research that reports on and critically discusses a wide range of topics concerning the theory and applications of positive systems.

Changing Configurations of Adult Education in Transitional Times. Conference Proceedings of the Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA) (7th, Berlin, Germany, September 4-7, 2013)

Science.gov (United States)

Käpplinger, Bernd, Ed.; Lichte, Nina, Ed.; Haberzeth, Erik, Ed.; Kulmus, Claudia, Ed.

2014-01-01

This book assembles over 50 papers from the 7th Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA), which was held from the 4th to the 7th of September 2013 at Humboldt-University in Berlin. The title of the conference was "Changing Configurations of Adult Education in Transitional…

Editorial: Papers from the 7th International Conference on Dendrochronology - Cultural Diversity, Environmental Variability

Science.gov (United States)

Margaret S. Devall; Elaine K. Sutherland

2008-01-01

The 7th International Conference on Dendrochronology - Cultural Diversity, Environmental Variability was held in Beijing, China from 11 to 17 June 2006. The conference was organized and hosted by the Institute of Botany, Chinese Academy of Sciences (IB_CAS) in conjunction with the International Union of Forest Research Organizations (IUFRO) Working Group 5.01.07 (Tree-...

Distributed Autonomous Robotic Systems : the 12th International Symposium

CERN Document Server

Cho, Young-Jo

2016-01-01

This volume of proceedings includes 32 original contributions presented at the 12th International Symposium on Distributed Autonomous Robotic Systems (DARS 2014), held in November 2014. The selected papers in this volume are authored by leading researchers from Asia, Europe, and the Americas, thereby providing a broad coverage and perspective of the state-of-the-art technologies, algorithms, system architectures, and applications in distributed robotic systems. .

EDITORIAL: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008 Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

Science.gov (United States)

Lobo, Alberto; Sopuerta, Carlos F.

2009-05-01

In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the symposium started at NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place in the city of Barcelona, Spain, 16-20 June, 2008, in the premises of CosmoCaixa, a modern science museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the symposium. Many of the most renowned world experts in LISA, gravitational wave science, and astronomy, as well as engineers, attended LISA #7 and produced state of the art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and eight parallel sessions in the afternoons. These were classified into seven major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave Sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. Abstracts for 138 communications were received, from which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the symposium website:http://www.ice.cat/research/LISA_Symposium. There was, however, a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main conference room, 320 seats—and were invited to ask questions to the speaker who boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas

7th european metallurgical conference EMC 2013

Directory of Open Access Journals (Sweden)

Srećko R. Stopić

2014-02-01

Full Text Available From June 23 – 26, 2013, the GDMB Society for Mining, Metallurgy, Resource and Environmental Technology organized 7th European Metallurgical Conference (EMC 2013 in Weimar, Germany. The previous European metallurgical conferences were organized by  the GDMB in Friedrichshafen (2001, Hanover (2003, Leipzig (2005, Duesseldorf (2007, Innsbruck (2009, and Duesseldorf (2011. The GDMB is a non-profit organization from Clausthal, Germany,,focused on combining science with practical experience in metallurgy, mining, materials engineering, mineral processing, recycling and refining of metals, and  manufacturing of semi- and finishing products. The European Metallurgical conference EMC is one of the most well-known conferences worldwide in the field of non-ferrous metallurgy and is attended regularly by decision makers from industry and universities. The scientific program contained 6 plenary lectures and more than 130 presentations. An extensive poster exhibition was held, during which the authors had an opportunity to introduce their posters to the entire plenum as a part of a brief presentation., The € 500 worth “Poster Award EMC 2011 was awarded to Christoph Pichler from the Montan-University in Leoben, Austria. Not only the most important European countries were represented here, but also more than one third of the lecturers were from countries outside Europe (Canada, Japan, China, USA, South Africa, Australia. The origin of the participants reflects the aim of the organizers: to make this conference a worldwide platform for the scientific exchange of experience and information. The scientific presentations of the conference are presented in Proceedings: Vol. 1: Copper, Precious Metals, Waste effluents Treatment/ Biohydrometallurgical applications; Process Metallurgy, Bridging Non-Ferrous and Ferrous Metallurgy; Vol. 2: Lead and Zinc, Light metals, Sustainable technologies, Sustainable of non-ferrous metals production, Process Control

7th IGRSM International Remote Sensing & GIS Conference and Exhibition

Science.gov (United States)

Shariff, Abdul Rashid Mohamed

2014-06-01

IGRSM This proceedings consists of the peer-reviewed papers from the 7th IGRSM International Conference and Exhibition on Remote Sensing & GIS (IGRSM 2014), which was held on 21-22 April 2014 at Berjaya Times Square Hotel, Kuala Lumpur, Malaysia. The conference, with the theme Geospatial Innovation for Nation Building was aimed at disseminating knowledge, and sharing expertise and experiences in geospatial sciences in all aspects of applications. It also aimed to build linkages between local and international professionals in this field with industries. Highlights of the conference included: Officiation by Y B Datuk Dr Abu Bakar bin Mohamad Diah, Deputy Minister of Minister of Science, Technology & Innovation Keynote presentations by: Associate Professor Dr Francis Harvey, Chair of the Geographic Information Science Commission at the International Geographical Union (IGU) and Director of U-Spatial, University of Minnesota, US: The Next Age of Discovery and a Future in a Post-GIS World. Professor Dr Naoshi Kondo, Bio-Sensing Engineering, University of Kyoto, Japan: Mobile Fruit Grading Machine for Precision Agriculture. Datuk Ir Hj Ahmad Jamalluddin bin Shaaban, Director-General, National Hydraulic Research Institute of Malaysia (NAHRIM), Malaysia: Remote Sensing & GIS in Climate Change Analyses. Oral and poster presentations from 69 speakers, from both Malaysia (35) and abroad (34), covering areas of water resources management, urban sprawl & social mobility, agriculture, land use/cover mapping, infrastructure planning, disaster management, technology trends, environmental monitoring, atmospheric/temperature monitoring, and space applications for the environment. Post-conference workshops on: Space Applications for Environment (SAFE), which was be organised by the Japan Aerospace Exploration Agency (JAXA) Global Positioning System (GPS) Receiver Evaluation Using GPS Simulation, which was be organised by the Science & Technology Research Institute for Defence

Systemic Th17/IL-17A response appears prior to hippocampal neurodegeneration in rats exposed to low doses of ozone.

Science.gov (United States)

Solleiro-Villavicencio, H; Rivas-Arancibia, S

2017-06-03

Exposure to low doses of O 3 leads to a state of oxidative stress. Some studies show that oxidative stress can modulate both the CNS and systemic inflammation, which are important factors in the development of Alzheimer disease (AD). This study aims to evaluate changes in the frequency of Th17-like cells (CD3 + CD4 + IL-17A + ), the concentration of IL-17A in peripheral blood, and hippocampal immunoreactivity to IL-17A in rats exposed to low doses of O 3 . One hundred eight male Wistar rats were randomly assigned to 6 groups (n=18) receiving the following treatments: control (O 3 free) or O 3 exposure (0.25ppm, 4hours daily) over 7, 15, 30, 60, and 90 days. Twelve animals from each group were decapitated and a peripheral blood sample was taken to isolate plasma and mononuclear cells. Plasma IL-17A was quantified using LUMINEX, while Th17-like cells were counted using flow cytometry. The remaining 6 rats were deeply anaesthetised and underwent transcardial perfusion for immunohistological study of the hippocampus. Results show that exposure to O 3 over 7 days resulted in a significant increase in the frequency of Th17-like cells and levels of IL-17A in peripheral blood. However, levels of Th17/IL-17A in peripheral blood were lower at day 15 of exposure. We also observed increased IL-17A in the hippocampus beginning at 30 days of exposure. These results indicate that O 3 induces a short-term, systemic Th17-like/IL-17A effect and an increase of IL-17A in the hippocampal tissue during the chronic neurodegenerative process. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

The USCACA hosted symposiums at the 7th CACA annual meeting and the 15th CSCO annual meeting in Beijing.

Science.gov (United States)

Shi, Michael; Yang, Wancai; Qian, Pascal; Yan, Li

2012-11-01

In September 2012, the US Chinese Anti-Cancer Association (USCACA) hosted two symposiums in Beijing. The USCACA hosted the first joint session at the 7th annual meetings of the Chinese Anti-Cancer Association (CACA), themed on "Collaboration between the US and China in Cancer Research." Six experts from the United States and China presented their latest work on basic and translational cancer research. During this symposium, 5 young Chinese scholars, returnees after their training in the United States, were honored the"AFCR-USCACA Scholarships Award." The USCACA hosted a second symposium during the 15th annual meeting of the Chinese Society of Clinical Oncology (CSCO), focused on the "US-China Collaboration in Cancer Drug Clinical Development." An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials, targeted therapy, and new drug development. The Oncology Drug Clinical Development and Safety Evaluation Committee was also launched to promote an innovative environment and to provide a collaborative platform for anti-cancer drug development in China.

EU-funded malaria research under the 6th and 7th Framework Programmes for research and technological development.

Science.gov (United States)

Holtel, Andreas; Troye-Blomberg, Marita; Penas-Jimenez, Inmaculada

2011-01-14

While malaria research has traditionally been strong in Europe, targeted and sustained support for cooperative malaria research at EU level, namely through the EU's 6th and 7th Framework Programmes for research and technological development, FP6 (2002-2006) and FP7 (2007-2013), has boosted both impact and visibility of European malaria research. Most of the European malaria research community is now organized under a number of comprehensive and complementary research networks and projects, assembled around four key areas: (1) fundamental research on the malaria parasite and the disease, (2) development of new malaria drugs, (3) research and development of a malaria vaccine, and (4) research to control the malaria-transmitting mosquito vector. Considerable efforts were undertaken to ensure adequate participation of research groups from disease-endemic countries, in particular from Africa, with the long-term aim to strengthen cooperative links and research capacities in these countries. The concept of organizing European research through major strategic projects to form a "European Research Area" (ERA) was originally developed in the preparation of FP6, and ERA formation has now turned into a major EU policy objective explicitly inscribed into the Lisbon Treaty. EU-funded malaria research may serve as a showcase to demonstrate how ERA formation can successfully be implemented in a given area of science when several surrounding parameters converge to support implementation of this strategic concept: timely coincidence of political stimuli, responsive programming, a clearly defined--and well confined--area of research, and the readiness of the targeted research community who is well familiar with transnational cooperation at EU level. Major EU-funded malaria projects have evolved into thematic and organizational platforms that can collaborate with other global players. Europe may thus contribute more, and better, to addressing the global research agenda for malaria.

European commission - 7th framework programme. The collaborative project on European sodium fast reactor (CP ESFR)

International Nuclear Information System (INIS)

Fiorini, G.L.

2009-01-01

The paper summarizes the key characteristics of the four years large Collaborative Project on European Sodium Fast Reactor (CP ESFR - 2009-2012); the CP ESFR follows the 6th FP project named 'Roadmap for a European Innovative SOdium cooled FAst Reactor - EISOFAR' further identifying, organizing and implementing a significant part of the needed R and D effort. The CP ESFR merges the contribution of 25 european partners; it will be realized under the aegis of the 7th FP under the Area - Advanced Nuclear Systems with a refund from the European Commission of 5.8 M euro (11.55 M euro total budget). It will be a key component of the European Sustainable Nuclear Energy Technology Platform (SNE TP) and its Strategic Research Agenda (SRA). The inputs for the project are the key research goals for fourth generation of European sodium cooled fast reactors which can be summarized as follow: an improved safety with in particular the achievement of a robust architecture vis a vis of abnormal situations and the robustness of the safety demonstrations; the guarantee of a financial risk comparable to that of the other means of energy production; a flexible and robust management of the nuclear materials and especially the waste reduction through the Minor Actinides burning. (author)

Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.

Science.gov (United States)

Zundler, Sebastian; Schillinger, Daniela; Fischer, Anika; Atreya, Raja; López-Posadas, Rocío; Watson, Alastair; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2017-11-01

Therapeutically targeting lymphocyte adhesion is of increasing relevance in IBD. Yet, central aspects of the action of antiadhesion compounds are incompletely understood. We investigated the role of αEβ7 and α4β7 integrins and their blockade by vedolizumab and etrolizumab for trafficking of IBD T lymphocytes in an in vivo model of homing to and retention in the inflamed gut. We explored integrin expression in patients with IBD by flow cytometry and immunohistochemistry, while regulation of integrins was studied in T cell cultures. The functional relevance of integrins was assessed by adhesion assays and a recently established humanised mouse model in dextran sodium sulfate-treated immunodeficient mice. High expression of αEβ7 was noted on CD8 + and CD4 + Th9 cells, while α4β7 was expressed on CD8 + , Th2 and Th17 cells. T cell receptor stimulation and transforming growth factor β were key inducers of αEβ7 on human T cells, while butyric acid suppressed αEβ7. In comparison to α4β7 blockade via vedolizumab, blockade of β7 via etrolizumab surrogate antibody superiorly reduced colonic numbers of CD8 + and Th9 cells in vivo after 3 hours, while no difference was noted after 0.5 hours. AEβ7 expression was higher on CD8 + T cells from patients with IBD under vedolizumab therapy. AEβ7 is of key relevance for gut trafficking of IBD CD8 + T cells and CD4 + Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of αEβ7 in addition to α4β7 may be particularly effective in intestinal disorders with expansion of CD8 + and Th9 cells such as IBD. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Design and Build of the Qinghai-Tibet Railway considering the Impacts of Warming Climate and Permafrost

Science.gov (United States)

Ma, W.; Jin, H.; Cheng, G.; Wu, Q.; Lai, Y.

2005-12-01

During the period from 1960 to 2000, an 1°C increase of air temperature has been observed along the Qinghai-Tibet Railway (QTR) traversing 632 km of warm and ice-rich permafrost through the interior of the Qinghai-Tibet Plateau. Correspondingly, mean annual ground temperatures (MAGTs) of warm (>-1 °C) permafrost on average increased about 0.3 to 0.5°C during 1970s-1990, while that of colder permafrost had increased by 0.1 to 0.3°C. During 1996-2004, ground temperatures at the permafrost table were increasing at the rates of 0.01-0.08°C a-1, and the permafrost table was lowering at the rates of 2.6 to 6.6 cm a-1; and the ground temperatures at depths of 6 to 8 m were warming at the rates of 0.02 to 0.05°C a-1. Consequently, the strengths of permafrost as the foundation of the QTR would be weakened if proper engineering measures were not taken. Based on the experiences and lessons learned from the road construction in permafrost regions from Alaska, Canada and Russia, and northeastern China, and taking into consideration of possible climatic warming along the QTR during the next 100 years, the design and construction of the QTR adopted the principle of``cooling the roadbed'' because most of the permafrost along the route is too deep to be thawed, too thermally sensitive to climatic warming and too critical to have appreciable thaw settlements. About 550 km of QTR is in continuous permafrost zone, 82 km is in discontinuous permafrost zone; 275 km is in warm permafrost areas, and 110 km of permafrost is ice-rich. The QTR is designed for safe operations during the next 100 years during which a warming of 2.2 to 2.6°C by 2050 is projected. Without engineering measures to keep ground frozen or maintain the settlement within the acceptable limits, thaw settlement in the foundation soils, and induced environmental instability would threaten the integrity and safety of QTR operation. However, only increasing therma resistance, such as increasing fill thickness or

Investigation of the system ThO2-NpO2-P2O5. Solid solutions of thorium-neptunium (IV) phosphate-diphosphate

International Nuclear Information System (INIS)

Dacheux, N.; Thomas, A.C.; Brandel, V.; Genet, M.

1998-01-01

Considering that phosphate matrices could be potential candidates for the immobilization of actinides or for the final disposal of the excess plutonium from dismantled nuclear weapons, the chemistry of thorium phosphates has been re-examined. In the ThO 2 -P 2 O 5 system, the thorium phosphate-diphosphate Th 4 (PO 4 ) 4 P 2 O 7 (TPD) can be synthesized by wet and dry chemical processes. The substitution of thorium by other tetravalent actinides like uranium or plutonium can be obtained for 0 4-x Np x (PO 4 ) 4 P 2 O 7 (TNPD) with 0 4+ by Np 4+ in the TPD structure is evaluated to 2.08 (which corresponds to about 52 mol% of thorium replaced by neptunium (IV)). The field of existence of solid solutions Th 4-x U -x Np -x Pu U x U Np x Np Pu x Pu (PO 4 )4P 2 O 7 has been calculated. These solid solutions should be synthesized for 5x U +7x Np +9x Pu ≤15. In the NpO 2 -P 2 O 5 system, the unit cell parameters of Np 2 O(PO 4 ) 2 were refined by analogy with U 2 O(PO 4 ) 2 which crystallographic data have been published recently. For Np 2 O(PO 4 ) 2 the unit cell is orthorhombic with the following cell parameters: a=7.033(2)A, b=9.024(3)A, c=12.587(6)A and V=799(1)A 3 . The unit cell parameter obtained for α-NpP 2 O 7 (a=8.586(1)A) is in good agreement with those already reported in literature. (orig.)

Effects of γ-rays on Th1 and Th2 immune function of mice

International Nuclear Information System (INIS)

Jin Wei; Cui Yufang; An Xiaoxia; Xu Han; Dong Bo; Liu Xiaolan; Luo Qingliang

2007-01-01

Objective: To observe the effects of 6 Gy whole body γ-irradiation on immune function of Th1 and Th2 in mouse, and to investigate the cellular and molecular mechanism of immune system injury induced by irradiation. Methods: Surface marker and intracellular cytokines of lymphocytes were stained with fluorescence-labeled monoclonal antibodies, then the changes of lymphocyte subpopulations, especially the Th1 and Th2 in mouse peripheral blood and spleen were analyzed by flow cytometry. Results: (1) 1 d after 6 Gy y- irradiation, lymphocytic subsets of CD 19 + and CD 8 + in spleen decreased apparently and the percentages of them were only 30% and 41% of control groups respectively (P 19 + and 14 d for CD 8 + respectively, however, up to 21 d post-irradiation they still did not return to control level. (2) Th1 subpopulations in mouse peripheral blood and spleen were significantly reduced at 1 d after irradiation and were only 2.6% and 7.6% of control groups (P 4 + / CD 8 + were significantly increased at 1 d post-irradiation in mouse spleen because of swift reduction of CD 8 + cells. Interestingly, either in peripheral blood or in spleen in irradiated mice, the ratio of Th1/Th2 were evidently raised because of the decrement of Th1 cells, exhibited obviously a phenomenon of predominant immune response of Th2 cells. Conclusions: It is suggested that the depression of mouse immune function induced by 6 Gy γ-irradiation might be caused by changes of CD 4 + /CD 8 + ratio, especially the imbalance of Th1/Th2 function subpopulations. It is shown that the imbalance of Th1/Th2 function subpopulations plays an important role in radiation-induced immune injury, thus providing a better insight into the molecular mechanism and new strategies for prevent and treatment measures of immune injury by irradiation. (authors)

36th national systems conference on recent advancements in system modelling applications

CERN Document Server

Krishnan, J

2013-01-01

The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 36th National System Conference (NSC 2012). NSC is an annual event of the Systems Society of India (SSI), primarily oriented to strengthen the systems movement and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad are invited to attend the Conference. The book presents various research articles in the area of system modelling in all disciplines of engineering sciences as well as socio-economic systems. The book can be used as a tool for further research.

Summary of the 10th International Conference on Human Herpesviruses-6 and -7 (HHV-6A, -6B, and HHV-7).

Science.gov (United States)

Komaroff, Anthony L; Boeckh, Michael; Eliason, Eva; Phan, Tuan; Kaufer, Benedikt B

2018-04-01

The 10th International Conference on Human herpesviruses-6 and -7 (HHV-6A, HHV-6B, and HHV-7) was held at the Freie Universität, Berlin, Germany from July 23-26, 2017. It attracted more than 130 basic, translational and clinical scientists from 19 countries. Important new information was presented regarding: the biology of HHV-6A and -6B; the biology and epidemiology of inherited chromosomally integrated HHV-6A and -6B; improved diagnostic tests; animal models for and animal viruses with similarities to HHV-6A, -6B, and -7; established and possible disease associations; and new treatment strategies. Here, we summarize work presented at the meeting that is of particular interest. © 2017 Wiley Periodicals, Inc.

Measurement of fission yields for 232-Th (n,f) at 14,7 MeV by direct gamma spectrometric method

International Nuclear Information System (INIS)

Chouak, K.; Berrada, M.; Embarech, K.

1994-01-01

Fission yields for the reaction 232-Th (n,f) were measured at 14,7 MeV using the activation technique with direct gamma spectrometric method. Neutrons were produced via the T(d,n) sup 4 He reaction. The neutron fluences were determined relative to the well-known sup 2 sup 7 Al(n,p) sup 2 sup 7 Mg or sup 2 sup 7 Al(n,alpha) sup 2 sup 4 Na cross section, according to the irradiation time. Yields of fission products were determined by measuring the induced gamma ray activities of the irradiated Th foils, using a calibrated Ge(Li) detector. All necessary corrections were taken into account: self absorption, coincidence losses and natural gamma rays. Fifty six cumulative yields were measured and only twenty one corresponding results were found in the literature (Crouch,1977). A satisfactory agreement is observed between our results and the published data with the exception of the masses:A=134 and A=140. 1 tab., 2 refs. (author)

7th World Congress on Engineering Asset Management

CERN Document Server

Choi, Byeongkuen; Ma, Lin; Mathew, Joseph

2015-01-01

These proceedings comprise 60 refereed papers of the Seventh World Congress on Engineering Asset Management (WCEAM) that was held in Deajeon City, Korea from 8-9 October 2012. The material is a compilation of state-of-the-art papers in the field covering a comprehensive range of subjects that are equally relevant to business managers and engineering professionals alike. Proceedings of the 7th World Congress on Engineering Asset Management (WCEAM 2012): Towards Integration and Interoperability in EAM covers a wide range of topics in the discipline of engineering asset management, including: ·         strategic asset management ·         condition monitoring and diagnostics ·         integrated intelligent maintenance ·         sensors and devices ·         information quality & management; ·         sustainability in asset management ·         asset performance and knowledge management ·         data mining and AI techniques in asset m...

Thorium Th

International Nuclear Information System (INIS)

Busev, A.I.; Tiptsova, V.G.; Ivanov, V.M.

1978-01-01

The basic methods for extracting thorium from monazites and determining it photometrically and complexometrically are described. Monazite is decomposed by fusion with sodium peroxide, then thorium and the totality of lanthanides are precipitated in the form of oxalates. After the oxalates have been broken down, thorium is determined photometrically with the aid of arsenazo 1, quercetin of 1-2(-pyridylazo)-resorcin. It takes 25 to 30 minutes to photometrically determine Th in monazites with the aid of arsenazo 2 (error: 3 to 5%). Arsenazo 2 is recommended for analysis of monazites containing 20 to 30% of lanthanides. Arsenazo 3 permits determining Th in zircon and in Nb-containing materials. In this case, the determination is possible in strongly acidic solutions, the ratio of arsenazo 3 to Th being 7.5:1. Arsenazo 3 can also be used in determining trace amounts of Th (1x10 -5 to 1x10 -4 %) in rocks, as well as in extraction-photometric determination of Th traces. The dyed compound of Th with arsenazo 3 is extracted with isoamyl alcohol in the presence of diphenylguanidinium chloride and monochloroacetic acid. The method permits determining Th at 1:5x10 8 (0.002 g/ml) dilution. Also described is the iodate-complexometric method for determining Th

Research in environmental impacts of peaceful uses of nuclear energy in the 7th five-year plan

International Nuclear Information System (INIS)

Horacek, P.

1982-01-01

The most complete information so far is presented in tabular form on research programs of organizations in the Czechoslovak Socialist Republic which in the 7th five year plan deal with the environmental impact of peaceful uses of nuclear energy. (author)

16th International Conference on Hybrid Intelligent Systems and the 8th World Congress on Nature and Biologically Inspired Computing

CERN Document Server

Haqiq, Abdelkrim; Alimi, Adel; Mezzour, Ghita; Rokbani, Nizar; Muda, Azah

2017-01-01

This book presents the latest research in hybrid intelligent systems. It includes 57 carefully selected papers from the 16th International Conference on Hybrid Intelligent Systems (HIS 2016) and the 8th World Congress on Nature and Biologically Inspired Computing (NaBIC 2016), held on November 21–23, 2016 in Marrakech, Morocco. HIS - NaBIC 2016 was jointly organized by the Machine Intelligence Research Labs (MIR Labs), USA; Hassan 1st University, Settat, Morocco and University of Sfax, Tunisia. Hybridization of intelligent systems is a promising research field in modern artificial/computational intelligence and is concerned with the development of the next generation of intelligent systems. The conference’s main aim is to inspire further exploration of the intriguing potential of hybrid intelligent systems and bio-inspired computing. As such, the book is a valuable resource for practicing engineers /scientists and researchers working in the field of computational intelligence and artificial intelligence.

Biosorption of Pb(II) ions by modified quebracho tannin resin

Energy Technology Data Exchange (ETDEWEB)

Yurtsever, Meral [Department of Environmental Engineering, Engineering Faculty, Sakarya University, 54187 Sakarya (Turkey)], E-mail: mevci@sakarya.edu.tr; Sengil, I. Ayhan [Department of Environmental Engineering, Engineering Faculty, Sakarya University, 54187 Sakarya (Turkey)

2009-04-15

In this study, the effect of temperature, pH and initial metal concentration on Pb(II) biosorption on modified quebracho tannin resin (QTR) was investigated. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to investigate QTR structure and morphology. Besides, the specific BET surface area and zeta-potential of the QTR were analysed. Thermodynamic functions, the change of free energy ({delta}G{sup o}), enthalpy ({delta}H{sup o}) and entropy ({delta}S{sup o}) of Pb adsorption on modified tannin resin were calculated as -5.43 kJ mol{sup -1} (at 296 {+-} 2 K), 31.84 kJ mol{sup -1} and 0.127 J mmol{sup -1} K{sup -1}, respectively, indicating the spontaneous, endothermic and the increased randomness nature of Pb{sup 2+} adsorption. The kinetic data was tested using pseudo-first-order, pseudo-second-order, Elovich and intraparticle diffusion model. The results suggested that the pseudo-second-order model (R{sup 2} > 0.999) was the best choice among all the kinetic models to describe the adsorption behavior of Pb(II) onto QTR. Langmuir, Freundlich and Tempkin adsorption models were used to represent the equilibrium data. The best interpretation for the experimental data was given by the Langmuir isotherm and the maximum adsorption capacity (86.207 mg g{sup -1}) of Pb(II) was obtained at pH 5 and 296 K.

Determination of 230Th/232Th and correct methods by High Resolution Inductively Coupled Plasma Mass Spectrometry

International Nuclear Information System (INIS)

Xie Shengkai; Guo Dongfa; Tan Jing; Zhang Yanhui; Huang Qiuhong; Gao Aiguo

2013-01-01

It is very important for the rapid and reliable determination of 230 Th/ 232 Th in the thorium-230 dating. A method of measuring 230 Th/ 232 Th in natural samples by high resolution inductively coupled plasma mass spectrometer (HR-ICP-MS) was developed on the base of our former work. The precise and accurate of natural 230 Th in geology samples is challenging, as the peak tailing to the high intensity of neighboring peak at 232 Th and the mass discrimination of the instrument. The peak tailing of 238 U to 236 U was used to decrease the peak tailing effect of 232 Th to 230 Th. The mass discrimination factor K between ture and measured isotope ratio was calculated after measuring different 230 Th/ 232 Th ratio solutions. Lab used standard samples was digested in mixed acids of HN0 3 -HF-HCI-HCl0 4 , and separated by the Bio-rad AG 1 × 8 Cl - resin. The measurement method of blank-standard-blank-sample procession was used to determinate the 230 Th/ 232 Th. The measured result of 230 Th/ 232 Th was at (7.29 ± 0.34) × 10 -6 , which agreed with the reference value of (7.33 ± 0.17) × 10 -6 . (authors)

Report on the first Quadrennial Technology Review (QTR)

Energy Technology Data Exchange (ETDEWEB)

None

2011-09-30

Access to clean, affordable, secure, and reliable energy has been a cornerstone of America’s economic growth. The Nation’s systems that produce, store, transmit, and use energy are falling short of U.S. needs. Maintaining energy security, bolstering U.S. competitiveness, and mitigating the environmental impacts of energy are long-­standing challenges. Governments, consumers, and the private sector have worked for decades to address these challenges, yet they remain among the Nation’s most pressing issues. President Obama has articulated broad national energy goals for reducing U.S. dependence on oil, reducing pollution, and investing in research and development (R&D) for clean-­energy technologies in the United States to create jobs. These include: Reducing oil imports by one-third by 2025; Supporting the deployment of 1 million electric vehicles on the road by 2015; Making non-residential buildings 20% more energy efficient by 2020; Deriving 80% of America's electricity from clean-energy sources by 2035; and Reducing greenhouse gas emissions by 175 by 2020 and 83% of 2050, from a 2005 baseline.

15th Kassel symposium energy systems technology. Renewable energy sources and E-mobility. Proceedings; 15. Kasseler Symposium Energie-Systemtechnik. Erneuerbare Energien und E-Mobilitaet. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Within the 15th Kassel symposium of power system engineering from 23th to 24th September, 2010, in Kassel (Federal Republic of Germany) the following lectures were held: (1) Transformation of energy systems and electromobility (Juergen Schmid); (2) Electromobility and renewable energies - scenarios and perspectives (Michael Weinhold); (3) Fraunhofer systems research electromobility (Ulrich Buller); (4) Renewable energies and electromobility - research promotion of the BMU (Alexander Folz); (5) Lithium ion batteries - a key component for electric vehicles (Klaus Brandt); (6) Virtual batteries and electromobility (Peter Caselitz); (7) Integration of electric vehicles into the grid - grid-to-vehicle (Zbigeniew Styczynski); (8) Intelligent grid interfaces for electric vehicles (Ulrich Reker); (9) Contactless grid connection of electric vehicles (Ulrich Reker); (10) Current converters for electric vehicles (Peter Zacharias); (11) Vehicle to grid communication interface (Joerg Heuer); (12) Business models electromobility (Anke Weidlich); (13) Hydrogen and electromobility - a future model? (Hubert Landinger).

PREFACE: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

Science.gov (United States)

Lobo, Alberto; Sopuerta, Carlos F.

2009-07-01

In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the Symposium started in NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place at the city of Barcelona, Spain, from 16-20 June 2008, in the premises of CosmoCaixa, a modern Science Museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the Symposium. Many of the most renowned world experts in LISA, Gravitational Wave Science, and Astronomy, as well as Engineers, attended LISA 7 and produced state-of-the-art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and 8 parallel sessions in the afternoons. These were classified into 7 major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. 138 abstracts for communications were received, of which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the Symposium website: http://www.ice.cat/research/LISA_Symposium. There was however a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main Conference Room, 320 seats—and were invited to ask questions to the speaker who had boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas of

7th Conference on Non-Integer Order Calculus and Its Applications

CERN Document Server

Dworak, Paweł

2016-01-01

This volume is devoted to presentation of new results of research on systems of non-integer order, called also fractional systems. Their analysis and practical implementation have been the object of spontaneous development for a few last decades. The fractional order models can depict a physical plant better than the classical integer order ones. This covers different research fields such as insulator properties, visco-elastic materials, electrodynamic, electrothermal, electrochemical, economic processes modelling etc. On the other hand fractional controllers often outperform their integer order counterparts. This volume contains new ideas and examples of implementation, theoretical and pure practical aspects of using a non-integer order calculus. It is divided into four parts covering: mathematical fundamentals, modeling and approximations, controllability, observability and stability problems and practical applications of fractional control systems. The first part expands the base of tools and methods of th...

Records of auroral candidates and sunspots in Rikkokushi, chronicles of ancient Japan from early 7th century to 887

Science.gov (United States)

Hayakawa, Hisashi; Iwahashi, Kiyomi; Tamazawa, Harufumi; Ebihara, Yusuke; Kawamura, Akito Davis; Isobe, Hiroaki; Namiki, Katsuko; Shibata, Kazunari

2017-12-01

We present the results of the surveys on sunspots and auroral candidates in Rikkokushi, Japanese official histories from the early 7th century to 887, to review the solar and auroral activities. In total, we found one sunspot record and 13 auroral candidates in Rikkokushi. We then examine the records of the sunspots and auroral candidates, compare the auroral candidates with the lunar phase to estimate their reliability, and compare the records of the sunspots and auroral candidates with the contemporary total solar irradiance reconstructed from radioisotope data. We also identify the locations of the observational sites to review possible equatorward expansion of the auroral oval. These discussions suggest a major gap in auroral candidates from the late 7th to early 9th centuries, which includes the candidate of the grand minimum reconstructed from the radioisotope data, a similar tendency as the distributions of sunspot records in contemporary China, and a relatively high magnetic latitude of observational sites with a higher potential for observing aurorae more frequently than at present.

Iterative solution of linear systems in the 20­th century

NARCIS (Netherlands)

Saad, Y.; Vorst, H.A. van der

2000-01-01

This paper sketches the main research developments in the area of iterative methods for solving linear systems during the 20th century. Although iterative methods for solving linear systems find their origin in the early nineteenth century (work by Gauss), the field has seen an explosion of

The particulate 7Be/210Pbxs and 234Th/210Pbxs activity ratios as tracers for tidal-to-seasonal particle dynamics in the Gironde estuary (France): Implications for the budget of particle-associated contaminants

International Nuclear Information System (INIS)

Saari, Hanna-Kaisa; Schmidt, Sabine; Castaing, Patrice; Blanc, Gerard; Sautour, Benoit; Masson, Olivier; Cochran, J. Kirk

2010-01-01

The short-lived natural radionuclides 7 Be (T 1/2 = 53 days), 234 Th xs (T 1/2 = 24.1 days) and 210 Pb xs (T 1/2 = 22.3 years), i.e. 234 Th and 210 Pb in excesses of that supported within particles by the decay of their parent isotopes, were analysed in suspended particulate matter (SPM) to study the particle dynamics in the Gironde fluvial estuarine system (France), strongly impacted by heavy metal pollution. From surveys of this land-ocean interface in 2006 and 2007, we established a times series of these radioisotopes and of their activity ratios ( 7 Be/ 210 Pb xs and 234 Th/ 210 Pb xs ARs) in particles sampled under different hydrological conditions. The particulate 7 Be/ 210 Pb xs AR varies along the fluvial estuarine system mainly due to variations in 7 Be activities, controlled by riverine, oceanic and atmospheric inputs and by resuspension of old 7 Be-deficient sediments. These processes vary with river discharge, tidal cycle and season. Therefore, seasonal particle transport processes can be described using variations of the SPM 7 Be/ 210 Pb xs ARs. During high river discharge, the SPM 7 Be/ 210 Pb x ARs decrease from river to the ocean. The turbidity maximum zone (TMZ) is dispersed and the particles, and the associated contaminants, are rapidly transported from river to coastal waters, without significant retention within the TMZ. During low river discharge, the TMZ intrudes into the fluvial estuary, and the lowest 7 Be/ 210 Pb x ARs are observed there due to resuspension of 7 Be-deficient sediments. Away from the TMZ, from the middle to lower estuary, SPM 7 Be/ 210 Pb x ARs increase, indicating that the particles have been recently tagged with 7 Be. We explain this trend as being caused by marine input of dissolved radionuclides, as traced by SPM 234 Th/ 210 Pb xs ARs, followed by scavenging in the estuary. This result indicates that particle transport models based on 7 Be and trace-metal budgets must consider oceanic dissolved inputs as an additional

8th Workshop on Coupled Descriptor Systems

CERN Document Server

Bartel, Andreas; Günther, Michael; Maten, E; Müller, Peter

2014-01-01

This book contains the proceedings of the 8th Workshop on Coupled Descriptor Systems held March 2013 in the Castle of Eringerfeld, Geseke in the neighborhood of Paderborn, Germany. It examines the wide range of current research topics in descriptor systems, including mathematical modeling, index analysis, wellposedness of problems, stiffness and different time-scales, cosimulation and splitting methods and convergence analysis. In addition, the book also presents applications from the automotive and circuit industries that show that descriptor systems provide challenging problems from the point of view of both theory and practice.   The book contains nine papers and is organized into three parts: control, simulation, and model order reduction. It will serve as an ideal resource for applied mathematicians and engineers, in particular those from mechanics and electromagnetics, who work with coupled differential equations.

9{sup th} international workshop on large-scale integration of wind power into power systems as well as on transmission networks for offshore wind power plants. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Betancourt, Uta; Ackermann, Thomas (eds.)

2010-07-01

Within the 9th International Workshop on large-scale integration of wind power into power systems as well as on transmission networks for offshore wind power plants at 18th to 19th October, 2010 in Quebec (Canada), lectures and poster papers were presented to the following themes: (1) Keynote session and panel; (2) European grid integration studies; (3) Modeling; (4) Wind forecasting; (5) North American grid integration studies; (6) Voltage stability and control; (7) Grid codes and impact studies; (8) Canadian University research (WESNet); (9) Operation and dispatch; (9) Offshore wind power plants; (10) Frequency Control; (11) Methodologies to estimate wind power impacts on power systems, summaries from IEAWIND collaboration; (12) HVDC; (13) Grid codes and system impact studies; (14) Modeling and validation; (15) Regulations, markets and offshore wind energy; (16) Integration issues; (17) Wind turbine control system; (18) Energy management and IT solutions.

9th International Symposium on Intelligent Distributed Computing

CERN Document Server

Camacho, David; Analide, Cesar; Seghrouchni, Amal; Badica, Costin

2016-01-01

This book represents the combined peer-reviewed proceedings of the ninth International Symposium on Intelligent Distributed Computing – IDC’2015, of the Workshop on Cyber Security and Resilience of Large-Scale Systems – WSRL’2015, and of the International Workshop on Future Internet and Smart Networks – FI&SN’2015. All the events were held in Guimarães, Portugal during October 7th-9th, 2015. The 46 contributions published in this book address many topics related to theory and applications of intelligent distributed computing, including: Intelligent Distributed Agent-Based Systems, Ambient Intelligence and Social Networks, Computational Sustainability, Intelligent Distributed Knowledge Representation and Processing, Smart Networks, Networked Intelligence and Intelligent Distributed Applications, amongst others.

Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension.

Science.gov (United States)

Magen, Eli; Feldman, Arie; Cohen, Ziona; Alon, Dora Ben; Minz, Evegeny; Chernyavsky, Alexey; Linov, Lina; Mishal, Joseph; Schlezinger, Menacham; Sthoeger, Zev

2010-02-01

A possible link between chronic vascular inflammation and arterial hypertension is now an object of intensive studies. To compare Th1/Th2/Th17 cells-related cytokines, circulating endothelial progenitor cells (EPC), and endothelial function in subjects with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Blood pressure was measured by electronic sphygmomanometer. EPC were identified as CD34+/CD133+/kinase insert domain receptor (KDR)+ cells by flow cytometry. Th1/Th2/Th17 cells-related cytokines were identified using the Human Th1/Th2/Th17 Cytokines MultiAnalyte ELISArray Kit. Endothelium-dependent (FMD) vasodilatation of brachial artery was measured by Doppler ultrasound scanning. RAH group (n = 20) and CAH group (n = 20) and 17 healthy individuals (control group) were recruited. In the RAH group, lower blood levels of EPC number (42.4 +/- 16.7 cells/mL) and EPC% (0.19 +/- 0.08%) were observed than in the CAH group (93.1 +/- 88.7 cells/mL; P = 0.017; 0.27 +/- 0.17; P = 0.036) and control group (68.5 +/- 63.6 cells/mL; P < 0.001; 0.28 +/- 0.17%; P = 0.003), respectively. Plasma transforming growth factor-beta1 levels were significantly higher in the RAH group (1767 +/- 364 pg/mL) than in the CAH group (1292 +/- 349; P < 0.001) and in control group (1203 +/- 419 pg/mL; P < 0.001). In the RAH group, statistically significant negative correlation was observed between systolic blood pressure and EPC% (r = -0.72, P < 0.01). FMD in the RAH group was significantly lower (5.5 +/- 0.8%) than in the CAH group (9.2 +/- 1.4; P < 0.001) and in healthy controls (10.1 +/- 1.1%; P < 0.001). RAH is characterized by reduced circulating EPC, substantial endothelial dysfunction, and increased plasma transforming growth factor-beta1 levels.

Profile of mathematics anxiety of 7th graders

Science.gov (United States)

Udil, Patrisius Afrisno; Kusmayadi, Tri Atmojo; Riyadi

2017-08-01

Mathematics anxiety is one of the important factors affect students mathematics achievement. This present research investigates profile of students' mathematics anxiety. This research focuses on analysis and description of students' mathematics anxiety level generally and its dominant domain and aspect. Qualitative research with case study strategy was used in this research. Subject in this research involved 15 students of 7th grade chosen with purposive sampling. Data in this research were students' mathematics anxiety scale result, interview record, and observation result during both mathematics learning activity and test. They were asked to complete mathematics anxiety scale before interviewed and observed. The results show that generally students' mathematics anxiety was identified in the moderate level. In addition, students' mathematics anxiety during mathematics test was identified in the high level, but it was in the moderate level during mathematics learning process. Based on the anxiety domain, students have a high mathematics anxiety on cognitive domain, while it was in the moderate level for psychological and physiological domains. On the other hand, it was identified in low level for psychological domain during mathematics learning process. Therefore, it can be concluded that students have serious and high anxiety regarding mathematics on the cognitive domain and mathematics test aspect.

FOREWORD: 26th IAHR Symposium on Hydraulic Machinery and Systems

Science.gov (United States)

Wu, Yulin; Wang, Zhengwei; Liu, Shuhong; Yuan, Shouqi; Luo, Xingqi; Wang, Fujun

2012-11-01

The 26th IAHR Symposium on Hydraulic Machinery and Systems, will be held in Beijing, China, 19-23 August 2012. It is jointly organized by Tsinghua University, State Key Laboratory of Hydro Science and Hydraulic Engineering, China, Jiangsu University, Xi'an University of Technology, China Agricultural University, National Engineering Research Center of Hydropower Equipment and Dongfang Electric Machinery Co., Ltd. It is the second time that China hosts such a symposium. By the end of 2011, the China electrical power system had a total of 1 050 GW installed power, out of which 220 GW was in hydropower plants. The energy produced in hydropower facilities was 662.6 TWh from a total of 4,720 TWh electrical energy production in 2011. Moreover, in 2020, new hydropower capacities are going to be developed, with a total of 180 GW installed power and an estimated 708 TWh/year energy production. And in 2011, the installed power of pumped storage stations was about 25GW. In 2020, the data will be 70GW. At the same time, the number of pumps used in China is increasing rapidly. China produces about 29,000,000 pumps with more than 220 series per year. By the end of 2011, the Chinese pumping system has a total of 950 GW installed power. The energy consumed in pumping facilities was 530 TWh in 2011. The pump energy consumption accounted for about 12% of the national electrical energy production. Therefore, there is a large market in the field of hydraulic machinery including water turbines, pump turbines and a variety of pumps in China. There are also many research projects in this field. For example, we have conducted National Key Research Projects on 1000 MW hydraulic turbine, and on the pump turbines with high head, as well as on the large capacity pumps for water supply. Tsinghua University of Beijing is proud to host the 26th IAHR Symposium on Hydraulic Machinery and Systems. Tsinghua University was established in 1911, after the founding of the People's Republic of China. It

The 25th European Conference on Information Systems (ECIS 2017

Directory of Open Access Journals (Sweden)

Michal Doležel

2017-12-01

Full Text Available This short note reports on my experience from The 25th European Conference on Information Systems (ECIS. The conference was titled “Information Systems for a smart, sustainable and inclusive world“, and took place in Guimarães, Portugal in June 2017. I discuss the thematic focus of the conference and its scope. Then I refer about two workshops I attended during the conference.

The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012.

Science.gov (United States)

Smith, Daniel; Alverdy, John; An, Gary; Coleman, Maureen; Garcia-Houchins, Sylvia; Green, Jessica; Keegan, Kevin; Kelley, Scott T; Kirkup, Benjamin C; Kociolek, Larry; Levin, Hal; Landon, Emily; Olsiewski, Paula; Knight, Rob; Siegel, Jeffrey; Weber, Stephen; Gilbert, Jack

2013-04-15

This report details the outcome of the 1st Hospital Microbiome Project workshop held on June 7th-8th, 2012 at the University of Chicago, USA. The workshop was arranged to determine the most appropriate sampling strategy and approach to building science measurement to characterize the development of a microbial community within a new hospital pavilion being built at the University of Chicago Medical Center. The workshop made several recommendations and led to the development of a full proposal to the Alfred P. Sloan Foundation as well as to the creation of the Hospital Microbiome Consortium.

13th International Conference Intelligent Autonomous Systems

CERN Document Server

Michael, Nathan; Berns, Karsten; Yamaguchi, Hiroaki

2016-01-01

This book describes the latest research accomplishments, innovations, and visions in the field of robotics as presented at the 13th International Conference on Intelligent Autonomous Systems (IAS), held in Padua in July 2014, by leading researchers, engineers, and practitioners from across the world. The contents amply confirm that robots, machines, and systems are rapidly achieving intelligence and autonomy, mastering more and more capabilities such as mobility and manipulation, sensing and perception, reasoning, and decision making. A wide range of research results and applications are covered, and particular attention is paid to the emerging role of autonomous robots and intelligent systems in industrial production, which reflects their maturity and robustness. The contributions have been selected through a rigorous peer-review process and contain many exciting and visionary ideas that will further galvanize the research community, spurring novel research directions. The series of biennial IAS conferences ...

Morphometric variations of the 7th cervical vertebrae of Zulu, White, and Colored South Africans.

Science.gov (United States)

Kibii, Job M; Pan, Rualing; Tobias, Phillip V

2010-05-01

The 7th cervical vertebrae of 240 cadavers of South African Zulu, White, and Colored population groups were examined to determine morphometric variation. White and Colored females had statistically significant narrower cervical anteroposterior diameters than their male counterparts, whereas no statistically significant difference between sexes of the Zulu population group was observed in this variable. In addition, although Zulu and Colored females had statistically significant narrower cervical transverse diameters than their male counterparts, there was no statistically significant variation between South African white males and females in this respect. The findings indicate that sexual dimorphism is more apparent in the vertebral centrum, across the three population groups, where males had significantly larger dimensions in centrum anteroposterior diameter, height, and width than their female counterparts. The study further reveals that sexual dimorphism is more apparent when one compares aspects of the 7th cervical vertebra between sexes within the same population group. Overall, the dimensions of the various variates of the vertebra are substantially smaller in women than in men. The smaller dimensions, particularly of the centrum, may be the result of lower skeletal mass in women and render them more vulnerable to fractures resulting from compression forces. 2010 Wiley-Liss, Inc.

FISA 2009 - 7th European Commission conference on EURATOM research and training in reactor systems. Conference proceedings

International Nuclear Information System (INIS)

Goethem, G. van; Manolatos, P.; Hugon, M.; Bhatnagar, V.; Deffrennes, M.; Webster, S.

2010-01-01

The main achievements of the first series of projects under EURATOM FP-7 for nuclear research and training activities (2007 to 2011) were discussed. Approximately 500 participants were registered at FISA 2009 and at the 7 post-conference workshops, representing a wide audience of nuclear scientists and decision makers coming from 32 countries worldwide. The focus of the conference was on scientific and technological research in the following areas: nuclear plant life management for existing reactors (Generation II), severe accident management (Generation III), assessment of future nuclear fission systems (Generation IV), partitioning and transmutation systems (innovative fuels), access to large research infrastructures, and nuclear education and training. Special attention was devoted to the societal and industrial goals of GIF: sustainability, industrial competitiveness, safety and reliability, proliferation resistance. (orig.)

8th international workshop on large-scale integration of wind power into power systems as well as on transmission networks for offshore wind farms. Proceedings

International Nuclear Information System (INIS)

Betancourt, Uta; Ackermann, Thomas

2009-01-01

Within the 8th International Workshop on Large-Scale Integration of Wind Power into Power Systems as well as on Transmission Networks for Offshore Wind Farms at 14th to 15th October, 2009 in Bremen (Federal Republic of Germany), lectures and posters were presented to the following sessions: (1) Keynote session and panel; (2) Grid integration studies and experience: Europe; (3) Connection of offshore wind farms; (4) Wind forecast; (5) High voltage direct current (HVDC); (6) German grid code issues; (7) Offshore grid connection; (8) Grid integration studies and experience: North America; (9) SUPWIND - Decision support tools for large scale integration of wind; (10) Windgrid - Wind on the grid: An integrated approach; (11) IEA Task 25; (12) Grid code issues; (13) Market Issues; (14) Offshore Grid; (15) Modelling; (16) Wind power and storage; (17) Power system balancing; (18) Wind turbine performance; (19) Modelling and offshore transformer.

Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

Science.gov (United States)

Zhang, Qian; Luan, Hong; Wang, Le; He, Fan; Zhou, Huan; Xu, Xiaoli; Li, Xingai; Xu, Qing; Niki, Toshiro; Hirashima, Mitsuomi; Xu, Gang; Lv, Yongman; Yuan, Jin

2014-04-15

Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a Th1- and Th17-predominant autoimmune disease. Galectin-9 (Gal-9), identified as the ligand of Tim-3, functions in diverse biological processes and leads to the apoptosis of CD4(+)Tim-3(+) T cells. It is still unclear how Gal-9 regulates the functions of Th1 and Th17 cells and prevents renal injury in anti-GBM GN. In this study, Gal-9 was administered to anti-GBM GN mice for 7 days. We found that Gal-9 retarded the increase of Scr, ameliorated renal tubular injury, and reduced the formation of crescents. The infiltration of Th1 and Th17 cells into the spleen and kidneys significantly decreased in Gal-9-treated nephritic mice. The reduced infiltration of Th1 and Th17 cells might be associated with the downregulation of CCL-20, CXCL-9, and CXCL-10 mRNAs in the kidney. In parallel, the blood levels of IFN-γ and IL-17A declined in Gal-9-treated nephritic mice at days 21 and 28. In addition, an enhanced Th2 cell-mediated immune response was observed in the kidneys of nephritic mice after a 7-day injection of Gal-9. In conclusion, the protective role of Gal-9 in anti-GBM GN is associated with the inhibition of Th1 and Th17 cell-mediated immune responses and enhanced Th2 immunity in the kidney.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

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Érika Machado de Salles

2017-08-01

Full Text Available A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune response to Plasmodium infection. Adenosine triphosphate (ATP accumulates in infected erythrocytes and is released into the extracellular milieu through ion channels in the erythrocyte membrane or upon erythrocyte rupture. The P2X7 receptor senses extracellular ATP and induces CD4 T cell activation and death. Here we show that P2X7 receptor promotes T helper 1 (Th1 cell differentiation to the detriment of follicular T helper (Tfh cells during blood-stage Plasmodium chabaudi malaria. The P2X7 receptor was activated in CD4 T cells following the rupture of infected erythrocytes and these cells became highly responsive to ATP during acute infection. Moreover, mice lacking the P2X7 receptor had increased susceptibility to infection, which correlated with impaired Th1 cell differentiation. Accordingly, IL-2 and IFNγ secretion, as well as T-bet expression, critically depended on P2X7 signaling in CD4 T cells. Additionally, P2X7 receptor controlled the splenic Tfh cell population in infected mice by promoting apoptotic-like cell death. Finally, the P2X7 receptor was required to generate a balanced Th1/Tfh cell population with an improved ability to transfer parasite protection to CD4-deficient mice. This study provides a new insight into malaria immunology by showing the importance of P2X7 receptor in controlling the fine-tuning between Th1 and Tfh cell differentiation during P. chabaudi infection and thus in disease outcome.

7th International Conference on Intelligent Systems and Knowledge Engineering

CERN Document Server

Li, Tianrui; Li, Hongbo

2014-01-01

These proceedings present technical papers selected from the 2012 International Conference on Intelligent Systems and Knowledge Engineering (ISKE 2012), held on December 15-17 in Beijing. The aim of this conference is to bring together experts from different fields of expertise to discuss the state-of-the-art in Intelligent Systems and Knowledge Engineering, and to present new findings and perspectives on future developments. The proceedings introduce current scientific and technical advances in the fields of artificial intelligence, machine learning, pattern recognition, data mining, knowledge engineering, information retrieval, information theory, knowledge-based systems, knowledge representation and reasoning, multi-agent systems, and natural-language processing, etc. Furthermore they include papers on new intelligent computing paradigms, which combine new computing methodologies, e.g., cloud computing, service computing and pervasive computing with traditional intelligent methods. By presenting new method...

Thermal expansion studies on Th(MoO4)2, Na2Th(MoO4)3 and Na4Th(MoO4)4

International Nuclear Information System (INIS)

Keskar, Meera; Krishnan, K.; Dahale, N.D.

2008-01-01

Thermal expansion behavior of Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 was studied under vacuum in the temperature range of 298-1123 K by high temperature X-ray diffractometer. Th(MoO 4 ) 2 was synthesized by reacting ThO 2 with 2 mol of MoO 3 , at 1073 K in air and Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were prepared by reacting Th(MoO 4 ) 2 with 1 and 2 mol of Na 2 MoO 4 , respectively at 873 K in air. The XRD data of Th(MoO 4 ) 2 was indexed on orthorhombic system where as XRD data of Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were indexed on tetragonal system. The lattice parameters and cell volume of all the three compounds, fit into polynomial expression with respect to temperature, showed positive thermal expansion (PTE) up to 1123 K. The average value of thermal expansion coefficients for Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were determined from the high temperature data

U and Th background contents in the Crimea rocks, Th/U ratio interpretation

International Nuclear Information System (INIS)

Gerasimov, Yu.G.; Voronova, M.A.; AN Ukrainskoj SSR, Kiev. Inst. Geologicheskikh Nauk)

1981-01-01

Radiogeochemical sampling of rocks in the Crimea is carried out. Analyses for U are made by luminescence method, while for Th by X-ray one. About 1000 samples, characterizing the whole stratigraphical cross section except Pz of crystalline rocks, have been analyzed. Low background values for U and Th are established; U content of 1.3-2.3 g/kg and Th content of 7.0-9.0 g/kg are predominant, that is lower than the clark of the earth crust. The distribution of radioelements in stepper and submontane Crimea is gradual, while in mountain part - the mosaic one. Results of Th/U ratios interpretation are presented [ru

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.

Science.gov (United States)

Ellinghaus, Ursula; Cortini, Andrea; Pinder, Christopher L; Le Friec, Gaelle; Kemper, Claudia; Vyse, Timothy J

2017-07-01

IFN-γ-producing T helper 1 (Th1) cell responses mediate protection against infections but uncontrolled Th1 activity also contributes to a broad range of autoimmune diseases. Autocrine complement activation has recently emerged as key in the induction and contraction of human Th1 immunity: activation of the complement regulator CD46 and the C3aR expressed by CD4 + T cells via autocrine generated ligands C3b and C3a, respectively, are critical to IFN-γ production. Further, CD46-mediated signals also induce co-expression of immunosuppressive IL-10 in Th1 cells and transition into a (self)-regulating and contracting phase. In consequence, C3 or CD46-deficient patients suffer from recurrent infections while dysregulation of CD46 signaling contributes to Th1 hyperactivity in rheumatoid arthritis and multiple sclerosis. Here, we report a defect in CD46-regulated Th1 contraction in patients with systemic lupus erythematosus (SLE). We observed that MMP-9-mediated increased shedding of soluble CD46 by Th1 cells was associated with this defect and that inhibition of MMP-9 activity normalized release of soluble CD46 and restored Th1 contraction in patients' T cells. These data may deliver the first mechanistic explanation for the increased serum CD46 levels observed in SLE patients and indicate that targeting CD46-cleaving proteases could be a novel avenue to modulate Th1 responses. © 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Proceedings of the 42nd basic science seminar. (The 7th workshop on neutron crystallography in biology)

International Nuclear Information System (INIS)

Niimura, Nobuo

1996-02-01

42nd advanced science seminar (the 7th workshop on neutron crystallography in biology) was held on October, 25-26, 1995 at Tokai. Forty three participants from university, research institute and private company took part in the workshop and there were 17 lectures given. The proceedings collect the figures and tables which the speakers used in their lectures. (author)

Thermodynamic assessment of the LiF–ThF4–PuF3–UF4 system

NARCIS (Netherlands)

Capelli, E.; Benes, O.; Konings, R.J.M.

2015-01-01

The LiF–ThF4–PuF3–UF4 system is the reference salt mixture considered for the Molten Salt Fast Reactor (MSFR) concept started with PuF3. In order to obtain the complete thermodynamic description of this quaternary system, two binary systems (ThF4–PuF3 and UF4–PuF3) and two ternary systems

15th International Conference on Biomedical Engineering

CERN Document Server

2014-01-01

This volume presents the proceedings of the 15th ICMBE held from 4th to 7th December 2013, Singapore. Biomedical engineering is applied in most aspects of our healthcare ecosystem. From electronic health records to diagnostic tools to therapeutic, rehabilitative and regenerative treatments, the work of biomedical engineers is evident. Biomedical engineers work at the intersection of engineering, life sciences and healthcare. The engineers would use principles from applied science including mechanical, electrical, chemical and computer engineering together with physical sciences including physics, chemistry and mathematics to apply them to biology and medicine. Applying such concepts to the human body is very much the same concepts that go into building and programming a machine. The goal is to better understand, replace or fix a target system to ultimately improve the quality of healthcare. With this understanding, the conference proceedings offer a single platform for individuals and organisations working i...

THE POSITION OF INTEREST IN SPORTS AND RECREATION OF 7th GRADE ELEMENTARY SCHOOL STUDENTS IN THE FACTOR ANALYSIS OF DIFFERENT INTEREST

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Vladimir Milošević

2013-07-01

Full Text Available Personal interests carry a great potential and are usually a drive to act. Therefore they usually point towards the activity of an individual in his interest area. An insight into the position of the interest in sports and recreation among other interests can be obtained by inspecting the interests of 7th grade elementary school students from Sremska Mitrovica and Jagodina. The sample consisted of 736 7th grade elementary school students of both genders. A non-experimental study of the students’ interests was done using a questionnaire that consisted of 5 interest indicators: job preference, self-estimation of affinity, use of free time, direct self-estimation of interests and reaction to key words-stimuli. Each indicator had 30 items that asses 30 interests. A t test was used to inspect the level of interest in sports and recreation. Also, factor analysis was done for each indicator separately. The reason for this approach is that there is no real confirmation that these 5 indicators are well suited for assessing the interests of young persons in the time we live in. Students’ interest in sports and recreation is about 4 on the scale of 1 to 5, on each of the indicators. The data shows that the interest of 7th grade elementary school students in sports and recreation is closely linked to interest in military, these two interests belong to the same factor regardless of the way the interests are assessed, that is, they belong to the same factor on each of the 5 indicators. The interest in adventure belongs to the same factor as the interest in sports and recreation on 4 out of 5 indicators, and interest in humor, interest in travel and hedonistic interest on 3 out of 5 indicators. These results might indicate that the motives for engaging in sports and recreation are unstable, because this composition of relatedness of the interests can be interpreted as the factor of fun. If that is so, these findings alert to the importance of building a

Summary report of the 7th reduced-moderation water reactor workshop

International Nuclear Information System (INIS)

Akie, Hiroshi; Nabeshima, Kunihiko; Uchikawa, Sadao

2005-08-01

As a research on the future innovative water reactor, the development of Reduced-Moderation Water Reactors (RMWRs) has been performed in Japan Atomic Energy Research Institute (JAERI). The workshop on RMWRs is aiming at information exchange between JAERI and other organizations such as universities, laboratories, utilities and vendors, and has been held every year since 1998. The 7th workshop was held on March 5, 2004 under the joint auspices of JAERI and North Kanto branch of Atomic Energy Society of Japan. The program of the workshop was composed of 5 lectures and an overall discussion time. The workshop started with the lecture by JAERI on the status and future program of PMWR research and development, followed by the two presentations by JAERI and Japan Nuclear Cycle Development Institute, respectively, on the investigation and evaluation of water cooled reactor in Feasibility Study Program on Commercialized Fast Reactor Systems. The lectures were also made on the Japan's nuclear fuel cycle and scenarios for RMWRs deployment by JAERI, and on the next generation reactor development activity by Hitachi, Ltd. The main subjects of the overall discussion time were Na cooled fast reactor, deployment effects of RMWRs and the future plan of the RMWR research and development. This report includes the original papers presented at the workshop and summaries of the questions and answers for each lecture, as well as of the discussion time. In addition in the Appendices, there are included presentation handouts of each lecture, program of the workshop and the participants list. (author)

7th International Workshop on Microbeam Probes of Cellular Radiation Response

Energy Technology Data Exchange (ETDEWEB)

Brenner, David J.

2009-07-21

The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia University’s Kellogg Center in New York City on March 15–17, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (1–5). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and ‘‘non-targeted’’ responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients

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Juliana Cruz da Silva

2013-06-01

Full Text Available OBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hydroxychloroquine in T helper 17 (Th17 cytokines in healthy individuals and patients. METHODS: Eighteen female patients with systemic lupus erythematosus (mean age 39.0±12.9 years and 13 female patients with rheumatoid arthritis (mean age 51.5±7.7 years were recruited from Universidade Federal de Pernambuco-Brazil. The patients were included after fulfilling four classification criteria for systemic lupus erythematosus or rheumatoid arthritis from the American College of Rheumatology. After being stimulated with phorbol 12-myristate 13-acetate and ionomycin in the absence or presence of different concentrations of hydroxychloroquine, the interleukin 6, 17 and 22 levels were quantified with an enzyme-linked immunosorbent assay in culture supernatants of peripheral blood mononuclear cells from healthy individuals and patients. RESULTS: We demonstrated that in peripheral blood mononuclear cells from healthy volunteers and in systemic lupus erythematosus and rheumatoid arthritis patients, there was a significant reduction in the IL-6, IL-17 and IL-22 supernatant levels after adding hydroxychloroquine. CONCLUSIONS Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication.

Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance

Science.gov (United States)

Martino, Matteo; Rocchi, Giulio; Escelsior, Andrea; Fornaro, Michele

2012-01-01

Neurotransmitters and hormones regulate major immune functions, including the selection of T helper (Th)1 or Th2 cytokine responses, related to cell-mediated and humoral immunity, respectively. A role of imbalance and dynamic switching of Th1/Th2 system has been proposed, with relative displacement of the immune reserve in relation to complex interaction between Th1/Th2 and neuro-hormonal balance fluctuations, in the pathogenesis of various chronic human diseases, probably also including psychiatric disorders. Components of the stress system such as norepinephrine (NE) and glucocorticoids appear to mediate a Th2 shift, while serotonin (5-HT) and melatonin might mediate a Th1 shift. Some antidepressants would occur affecting these systems, acting on neurotransmitter balance (especially the 5-HT/NE balance) and expression levels of receptor subtypes, which in turn affect cytokine production and relative Th1/Th2 balance. It could be therefore hypothesized that the antidepressant-related increase in NE tone enhances the Th2 response, while the decrease in NE tone or the increase in 5-HT tone enhances the Th1 response. However, the neurotransmitter and Th1/Th2 balance modulation could be relative, aiming to restore physiological levels a previous imbalance in receptor sensitivity and cytokine production. The considerations on neuro-immunomodulation could represent an additional aid in the study of pathophysiology of psychiatric disorders and in the choice of specific antidepressants in specific clusters of symptoms, especially in comorbidity with internal pathologies. Furthermore limited data, reviewed here, have shown the effectiveness of some antidepressants as pure immunomodulators. However, these considerations are tentative and require experimental confirmation or refutation by future studies. PMID:23204981

6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning

CERN Document Server

Prieta, Fernando; Mascio, Tania; Gennari, Rosella; Rodríguez, Javier; Vittorini, Pierpaolo

2016-01-01

The 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning held in Seville (Spain) is host by the University of Seville from 1st to 3rd June, 2016. The 6th edition of this conference expands the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions or web-based ones. It intends to bring together researchers and developers from industry, the education field and the academic world to report on the latest scientific research, technical advances and methodologies.

7TH Annual Anesthesia and Critical Care Symposium (7th) Held in Paris (France) on 22-24 April 1994,

Science.gov (United States)

1994-09-30

Amphitheatre Poincare DIMANCHE 24 AVRIL / SUNDAY APRIL 24th TRAUMATISME CRANIEN CHEZ L’ENFANT HEAD TRA UMA IN CHILDREN Mod6rateurs : J. BERMAN (Winston...Salem, Etats-Unis), Ph. MEYER (Paris, France) 08h30 Epid6miologie et physio-pathologie des traumatismes craniens chez 1’enfant Epidemiology and...pathophysiology of head injuries in children P. OAKLEY (Staffordshire, Royaume-Uni) 09h00 R6animation pr6-hospitali~re du traumatisme cranien grave

PREFACE: 7th EEIGM International Conference on Advanced Materials Research

Science.gov (United States)

Joffe, Roberts

2013-12-01

The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF

Center or periphery? The system of public administration in Tuva in the end of the 19th and early 20th centuries

Directory of Open Access Journals (Sweden)

Салимаа Сергеевна Ховалыг

2010-09-01

Full Text Available The article deals with formation and development of the government power system and the management in Tuva in the 19-20th centuries. The state apparatus, the hierarchy of ranks and degrees of distinction of the state posts of Tuva are examined. The creation problems of the organization of the power of Russia in the region are analyzed in this article. In connection with it, in the beginning of the 20th century Tuva was accepted as a protectorate of Russia.

4th International Conference on Communications, Signal Processing, and Systems

CERN Document Server

Mu, Jiasong; Wang, Wei; Zhang, Baoju

2016-01-01

This book brings together papers presented at the 4th International Conference on Communications, Signal Processing, and Systems, which provides a venue to disseminate the latest developments and to discuss the interactions and links between these multidisciplinary fields. Spanning topics ranging from Communications, Signal Processing and Systems, this book is aimed at undergraduate and graduate students in Electrical Engineering, Computer Science and Mathematics, researchers and engineers from academia and industry as well as government employees (such as NSF, DOD, DOE, etc).

12th International Conference on Intelligent Autonomous Systems

CERN Document Server

Cho, Hyungsuck; Yoon, Kwang-Joon; Lee, Jangmyung

2013-01-01

Intelligent autonomous systems are emerged as a key enabler for the creation of a new paradigm of services to humankind, as seen by the recent advancement of autonomous cars licensed for driving in our streets, of unmanned aerial and underwater vehicles carrying out hazardous tasks on-site, and of space robots engaged in scientific as well as operational missions, to list only a few. This book aims at serving the researchers and practitioners in related fields with a timely dissemination of the recent progress on intelligent autonomous systems, based on a collection of papers presented at the 12th International Conference on Intelligent Autonomous Systems, held in Jeju, Korea, June 26-29, 2012. With the theme of “Intelligence and Autonomy for the Service to Humankind, the conference has covered such diverse areas as autonomous ground, aerial, and underwater vehicles, intelligent transportation systems, personal/domestic service robots, professional service robots for surgery/rehabilitation, rescue/security ...

Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus.

Science.gov (United States)

Piccinni, M-P; Lombardelli, L; Logiodice, F; Tesi, D; Kullolli, O; Biagiotti, R; Giudizi, Mg; Romagnani, S; Maggi, E; Ficarra, G

2014-03-01

The role of Th17 cells and associated cytokines was investigated in oral lichen planus. 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1β, RANTES, IL-4, IL-12B, IL-8, IFN-γ, TNF-α, IL-1α, IL-18, TGF-β1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. Results showed that Th17-type and Th0-type molecules' mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules' mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MAGLEV `95. 14th international conference on magnetically levitated systems. Proceedings

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The proceedings present the papers of the 14th International Conference on Magnetically Levitated Systems held in Bremen, FRG, in November 1995. For 70 of 74 papers a separate subject analysis has been carried out. 4 papers are not available in the proceedings. (HW)

The 7th Japan-Taiwan joint meeting on neutron and X-ray scattering. Proceedings

International Nuclear Information System (INIS)

2016-03-01

The 7th Japan-Taiwan joint meeting on neutron and X-ray scattering in Kumatori is held bilaterally in Japan and Taiwan. This meeting provides the recent outstanding results in the fields of fundamental polymer and biological sciences and their applications as well. In the fields of the X-ray and/or neutron scattering, the methodological progress expands the research fields and gives us new scientific insights. This meeting invites the researchers developing new methodologies, such as dynamics measurement utilizing nuclear Bragg resonance, subunit-kinetics measurement with deuteration-assisted small-angle neutron scattering and so on. (J.P.N.)

Spin glass properties of Y0.7Ca0.3MnO3 and Th0.35Ba0.37Ca0.28MnO3

Science.gov (United States)

Sedmidubský, D.; Hejtmánek, J.; Maryško, M.; Jirák, Z.; Hardy, V.; Martin, C.

2002-05-01

Two perovskite manganites with the same nominal concentration of Mn4+ have been studied by the magnetic susceptibility and specific heat measurements: the Y0.7Ca0.3MnO3 single crystal (YCa) with low tolerance factor and negligible ionic radii variance and the Th0.35Ba0.37Ca0.28MnO3 (ThBaCa) ceramics with favorable tolerance factor but huge substitution induced disorder. Both systems were found to possess an insulating ground state with activated conductivity. The ac susceptibility data exhibit a frequency dependent peak at Tsg=32 K for YCa and Tsg=43 K for ThBaCa. The Cole-Cole analysis revealed a sharper than exponential increase of the relaxation time for the former sample while almost linear slowly growing characteristics below Tsg were observed for the latter one. Using the heat capacity curves, the magnetic contribution was separated and magnetic peaks with typical linear on-set tails were obtained. This observation and the abovementioned characteristics are all indicative of spin or cluster glass character. The necessary magnetic frustration is here induced by a considerable tilting of MnO6 octahedra and deformation of Mn-O bonds which occur in a cooperative manner for YCa and locally for ThBaCa.

7th conference on ultra-wideband, short-pulse electromagnetics

CERN Document Server

Schenk, Uwe; Nitsch, Daniel; Sabath, Frank; Ultra-Wideband, Short-Pulse Electromagnetics 7; UWBSP7

2007-01-01

Ultra-wideband (UWB), short-pulse (SP) electromagnetics are now being used for an increasingly wide variety of applications, including collision avoidance radar, concealed object detection, and communications. Notable progress in UWB and SP technologies has been achieved by investigations of their theoretical bases and improvements in solid-state manufacturing, computers, and digitizers. UWB radar systems are also being used for mine clearing, oil pipeline inspections, archeology, geology, and electronic effects testing. Ultra-Wideband Short-Pulse Electromagnetics 7 presents selected papers of deep technical content and high scientific quality from the UWB-SP7 Conference, including wide-ranging contributions on electromagnetic theory, scattering, UWB antennas, UWB systems, ground penetrating radar (GPR), UWB communications, pulsed-power generation, time-domain computational electromagnetics, UWB compatibility, target detection and discrimination, propagation through dispersive media, and wavelet and multi-res...

14th International Conference on Intelligent Autonomous Systems

CERN Document Server

Hosoda, Koh; Menegatti, Emanuele; Shimizu, Masahiro; Wang, Hesheng

2017-01-01

This book describes the latest research advances, innovations, and visions in the field of robotics as presented by leading researchers, engineers, and practitioners from around the world at the 14th International Conference on Intelligent Autonomous Systems (IAS-14), held in Shanghai, China in July 2016. The contributions amply demonstrate that robots, machines and systems are rapidly achieving intelligence and autonomy, attaining more and more capabilities such as mobility and manipulation, sensing and perception, reasoning, and decision-making. They cover a wide range of research results and applications, and particular attention is paid to the emerging role of autonomous robots and intelligent systems in industrial production, which reflects their maturity and robustness. The contributions were selected by means of a rigorous peer-review process and highlight many exciting and visionary ideas that will further galvanize the research community and spur novel research directions. The series of biennial IAS ...

9th Workshop on Cyclostationary Systems and Their Applications

CERN Document Server

Leskow, Jacek; Napolitano, Antonio; Zimroz, Radoslaw; Wylomanska, Agnieszka

2017-01-01

This book gathers contributions presented at the 9th Workshop on Cyclostationary Systems and Their Applications, held in Gródek nad Dunajcem, Poland in February 2016. It includes both theory-oriented and practice-oriented chapters. The former focus on heavy-tailed time series and processes, PAR models, rational spectra for PARMA processes, covariance invariant analysis, change point problems, and subsampling for time series, as well as the fraction-of-time approach, GARMA models and weak dependence. In turn, the latter report on case studies of various mechanical systems, and on stochastic and statistical methods, especially in the context of damage detection. The book provides students, researchers and professionals with a timely guide to cyclostationary systems, nonstationary processes and relevant engineering applications.

7th International Conference on Embedded and Multimedia Computing (EMC-12)

CERN Document Server

Jeong, Young-Sik; Park, Sang; Chen, Hsing-Chung; Embedded and Multimedia Computing Technology and Service

2012-01-01

The 7th International Conference on Embedded and Multimedia Computing (EMC-12), will be held in Gwangju, Korea on September 6 - 8, 2012. EMC-12 will be the most comprehensive conference focused on the various aspects of advances in Embedded and Multimedia (EM) Computing. EMC-12 will provide an opportunity for academic and industry professionals to discuss the latest issues and progress in the area of EM. In addition, the conference will publish high quality papers which are closely related to the various theories and practical applications in EM. Furthermore, we expect that the conference and its publications will be a trigger for further related research and technology improvements in this important subject. The EMC-12 is the next event, in a series of highly successful International Conference on Embedded and Multimedia Computing, previously held as EMC 2011 (China, Aug. 2011), EMC 2010 (Philippines, Aug. 2010), EM-Com 2009 (Korea, Dec. 2009), UMC-08 (Australia, Oct. 2008), ESO-08(China, Dec. 2008), UMS-08 ...

Laser excitation of 8-eV electronic states in Th{sup +}. A first pillar of the electronic bridge toward excitation of the Th-229 nucleus

Energy Technology Data Exchange (ETDEWEB)

Herrera-Sancho, Oscar-Andrey

2012-11-23

The possibility to realize a nuclear clock based on the optical magnetic dipole transition from the ground state to the low-energy isomeric state in the {sup 229}Th nucleus has motivated experiments and proposals toward highly accurate clocks with trapped ions and highly stable optical frequency standards with Th-doped solids. These systems hold great promise to open a field of research in the borderland between atomic and nuclear physics, which will enable highly sensitive tests of postulates from fundamental physics and also will allow us to coherently excite and control nuclear states, opening a wonderful and intriguing new field in physics. A major experimental obstacle that has to be overcome before any precision spectroscopy can be performed with this system is however the insufficient knowledge on the exact transition energy. The best experimental result so far is an indirect determination from {gamma}-spectroscopy with a relative uncertainty of about 6%. To facilitate the search for the nuclear transition within a wide uncertainty range around 8 eV, we investigate two-photon excitation in the dense electronic level structure of Th{sup +}, which enables the nuclear excitation via a resonantly enhanced inverse electronic bridge process. Experiments on one- and two-photon laser excitation of buffer gas cooled {sup 232}Th{sup +} ions in a radio-frequency ion trap are reported in this thesis. The strongest resonance line at 402 nm from the (6d{sup 2}7s)J=3/2 ground state to the (6d7s7p)J=5/2 state is driven as the first excitation step. Using nanosecond laser pulses in the 250-nm wavelength range for the second step of a two-photon excitation, we have observed seven previously unknown levels in the unexplored region of the electronic level structure around 8 eV. This investigation shows that the Th{sup +} ion seems to be well suited for the search of the isomer transition because both, theory and experimental results, agree on the density of strong transitions

Papers presented at the 7th status report of the Reprocessing and Waste Treatment Project

International Nuclear Information System (INIS)

1988-10-01

The report contains all lectures on the present state of the R+D work which were delivered on the occasion of the 7th seminar on the present state of the Reprocessing and Waste Treatment Project in the Karlsruhe Nuclear Research Centre on 15/16 March 1988. The project is aimed at improving methods for nuclear waste disposal with regard to the German reprocessing plant for light-water reactor fuels currently under construction in Wackersdorf. The individual contributions were separately adapted for the INIS and EDB data banks. (RB) [de

Superconductivity in the U(Th)-Y-Ba-Cu-O systems

International Nuclear Information System (INIS)

Qin Qizong; He Adi; Jia Weijie; Ma Lidun; Cheng Huansheng; Hua Zhongyi

1989-01-01

High T c superconductivity has been observed both resistively and magnetically in the new U(Th)-Y-Ba-Cu-O systems. The zero resistance temperature of the three samples with nominal composition of U 0.1 Y 1.1 Ba 0.8 Cu O 4-z , U 0.15 Y 1.05 Ba 0.8 Cu 4-z and Th 0.3 Y 0.8 Ba 0.8 Cu 4-z is 87K, 79K and 74K, respectively. The result of ac magnetic susceptibility measurement implies that the superconducting state is realized in the U-doped samples below 90K. The stoichimetry of the U-Y-Ba-Cu O superconductors has the aid of Rutherford backscattering and nuclear reaction 16 O(d, p) 17 O. The analytical results show that the 'real composition' of somples may be different from that of the nomial composition. The X ray diffraction analysis of the U-Y-Ba-Cu-O system shows that none of the peaks can be fitted to the uranium oxides and the other raw materiale structure, and its pattern may be attributed to new multiple phases with structure different from the known singlephase superconducting oxides

System Software 7 Macintosh

CERN Multimedia

1991-01-01

System 7 is a single-user graphical user interface-based operating system for Macintosh computers and was part of the classic Mac OS line of operating systems. It was introduced on May 13, 1991, by Apple Computer. It succeeded System 6, and was the main Macintosh operating system until it was succeeded by Mac OS 8 in 1997. Features added with the System 7 release included virtual memory, personal file sharing, QuickTime, QuickDraw 3D, and an improved user interface. This is the first real major evolution of the Macintosh system, bringing a significant improvement in the user interface, improved stability and many new features such as the ability to use multiple applications at the same time. "System 7" is the last operating system name of the Macintosh that contains the word "system". Macintosh operating systems were later called "Mac OS" (for Macintosh Operating System).

Process evaluation for a school-based physical activity intervention for 6th- and 7th-grade boys: reach, dose, and fidelity.

Science.gov (United States)

Robbins, Lorraine B; Pfeiffer, Karin Allor; Wesolek, Stacey M; Lo, Yun-Jia

2014-02-01

The purpose was to evaluate the reach, dose, and fidelity of Guys Only Activity for Life (G.O.A.L.), a 7-week pilot intervention conducted from February to March 2011 to increase 6th and 7th grade boys' moderate-to-vigorous physical activity (MVPA). One middle school was randomly assigned to the G.O.A.L. intervention and another from the same urban school district in the Midwestern U.S. to a comparison condition. Thirty boys, ages 10-14 years, participated in each school. The intervention, guided by the Health Promotion Model (HPM) and Self-Determination Theory (SDT), consisted of a 90-min after-school physical activity club 4 days/week and one motivational interviewing session with a registered (school) nurse. Data were gathered via attendance records, club observations, heart rate monitors, audio-taping of motivational interviewing sessions, and surveys. On average boys attended the club 2.11 days/week (SD=.86). A trained independent process evaluator reported that the physical activity club instructors provided the boys with the opportunity for a mean of 25.8 min/day of MVPA. Using a four-point Likert scale (1=disagree a lot; 4=agree a lot), the process evaluator perceived that the club was delivered with high fidelity and adherence to the underlying theories (M=3.48; SD=0.39). Sessions with the nurse lasted an average of 13 min, 29 s. All boys attended. Two trained independent coders indicated that the nurse demonstrated at least beginning proficiency for all tasks associated with motivational interviewing, with the exception of using sufficient open- as opposed to closed-ended questions and reflections compared to questions. Fidelity related to session delivery and adherence to the theories was high (M=3.83; SD=0.19). The process evaluation data indicated that strategies are needed to increase attendance and boys' MVPA during the club time. Copyright © 2013 Elsevier Ltd. All rights reserved.

CD28 co-stimulation down regulates Th17 development.

Directory of Open Access Journals (Sweden)

Salim Bouguermouh

Full Text Available Th17 cells are implicated in host defence and autoimmune diseases. CD28/B7 co-stimulation is involved in the induction and progression of autoimmune diseases, but its role in controlling murine Th17 cell fate remains to be clarified. We here report that soluble anti-CD28 mAb suppressed the differentiation of anti-CD3-stimulated naïve CD4(+ T cells into IL-17-producing cells. CD28 co-stimulation reduced the frequency of proliferating cells that produce IL-17. We provide evidence for an IL-2 and IFN-gamma-dependent mechanism of CD28-mediated IL-17 suppression. CD28 blockade of Th17 development was correlated with a decrease rather than an increase in the percentage of Foxp3(+ T cells. In APC/T cell co-cultures, mature dendritic cells (DC were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation. This study identifies the importance of B7 co-stimulatory molecules in the negative regulation of Th17 development. These unexpected results caution targeting the CD28/B7 pathways in the treatment of human autoimmune diseases.

Proceedings of the 7th Italian conference on general relativity and gravitational physics

International Nuclear Information System (INIS)

Bruzzo, U.; Cianci, R.; Massa, E.

1987-01-01

The 7th Italian Conference on General Relativity and Gravitational Physics was held in Rapallo (Genoa), from September 3 to 6, 1986, under the auspices of the International Society on General Relativity and Gravitation. Like the previous conferences of this series, it brought together physicists, mathematicians, and astronomers interested in various aspects of relativity, field theory, astrophysics, and cosmology. The scientific program included two types of sessions: invited lectures and workshops for presenting contributed papers. All these have been grouped into four main sections. The divisions are the following: A: General Relativity; B: Field Theory, Supergravity, and Strings; C: Relativistic Astrophysics and Cosmology; D: Experimental and Observational Relativity. This book presents the papers discussed in the meetings on the above mentioned subjects

9th International Conference on Knowledge, Information and Creativity Support Systems

CERN Document Server

Papadopoulos, George; Skulimowski, Andrzej; Kacprzyk  , Janusz

2016-01-01

This volume consists of a number of selected papers that were presented at the 9th International Conference on Knowledge, Information and Creativity Support Systems (KICSS 2014) in Limassol, Cyprus, after they were substantially revised and extended. The 27 regular papers and 19 short papers included in this proceedings cover all aspects of knowledge management, knowledge engineering, intelligent information systems, and creativity in an information technology context, including computational creativity and its cognitive and collaborative aspects. .

Effects of the 5th and 7th Grade Enhanced Versions of the "keepin' it REAL" Substance Use Prevention Curriculum

Science.gov (United States)

Elek, Elvira; Wagstaff, David A.; Hecht, Michael L.

2010-01-01

This study assessed the outcomes of adapting the culturally-grounded, middle school, substance-use prevention intervention, "keepin' it REAL" ("kiR"), to target elementary school students and to address acculturation. At the beginning of 5th grade, 29 schools were randomly assigned to conditions obtained by crossing grade of implementation (5th,…

7th annual congress of the Swiss Society of Nuclear Medicine (SGNM/SSMN). Main topic: imaging in oncology. Abstracts

International Nuclear Information System (INIS)

2006-01-01

Program chart and compiled abstracts of the 7th annual congress of the Swiss Society of Nuclear Medicine (SGNM/SSMN). Session headers are: imaging in oncology: PET-CT; oncology: therapy; imaging in oncology: treatment response; oncology: peptides; oncology: basic scinence; imaging in oncology: bone and soft tissue tumors; instrumentation; oncology: imaging. (uke)

Th1, Th17, CXCL16 and homocysteine elevated after intracranial and cervical stent implantation.

Science.gov (United States)

Tang, Yanyan; Wei, Yunfei; Ye, Ziming; Qin, Chao

2017-08-01

The presence of Th1 and Th17 cells has been observed as major inducers in inflammation and immune responses associated stenting. However, there is rare data on the impact of Th1, Th17, CXCL16 and homocysteine after cerebral stent implantation. Here, we performed the statistical analysis to first evaluate the variation of the Th17and Th1 cells and their related cytokines, CXCL16 and homocysteine in the peripheral blood of patients with cerebral stenting. The flow cytometry was used to detect the proportion of Th1 and Th17 cells in peripheral blood mononuclear cells (PBMCs). The enzyme-linked immunosorbent assay was used to measure the serum concentrations of IFN-γ, IL-17 and CXCL16. Plasma homocysteine was examined by immunoturbidimetry. The level of Th1, CXCL16 and homocysteine showed an increase at 3 d, followed by the continuous decrease at 7 d and 3 months. The frequency of Th17 cells increased to a peak at three days, and subsequently decreased with a higher level than baseline. Our data revealed that the variation in Th1, Th17, CXCL16 and homocysteine in peripheral blood of patients with stenting may be implicated in inflammation after intracranial and cervical stent implantation. A better understanding of these factors will provide help for further drug design and clinical therapy.

16th UK Workshop on Computational Intelligence

CERN Document Server

Gegov, Alexander; Jayne, Chrisina; Shen, Qiang

2017-01-01

The book is a timely report on advanced methods and applications of computational intelligence systems. It covers a long list of interconnected research areas, such as fuzzy systems, neural networks, evolutionary computation, evolving systems and machine learning. The individual chapters are based on peer-reviewed contributions presented at the 16th Annual UK Workshop on Computational Intelligence, held on September 7-9, 2016, in Lancaster, UK. The book puts a special emphasis on novels methods and reports on their use in a wide range of applications areas, thus providing both academics and professionals with a comprehensive and timely overview of new trends in computational intelligence.

Proceedings of the 7th US/German Workshop on Salt Repository Research, Design, and Operation.

Energy Technology Data Exchange (ETDEWEB)

Hansen, Francis D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Steininger, Walter [Karisruhe Inst. of Technology (Germany); Bollingerfehr, Willhelm [DBE TECHNOLOGY GmbH (Germany)

2017-01-01

The 7th US/German Workshop on Salt Repository Research, Design, and Operation was held in Washington, DC on September 7-9, 2016. Over fifty participants representing governmental agencies, internationally recognized salt research groups, universities, and private companies helped advance the technical basis for salt disposal of radioactive waste. Representatives from several United States federal agencies were able to attend, including the Department of Energy´s Office of Environmental Management and Office of Nuclear Energy, the Environmental Protection Agency, the Nuclear Regulatory Commission, and the Nuclear Waste Technical Review Board. A similar representation from the German ministries showcased the covenant established in a Memorandum of Understanding executed between the United States and Germany in 2011. The US/German workshops´ results and activities also contribute significantly to the Nuclear Energy Agency Salt Club repository research agenda.

Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7

Science.gov (United States)

Bi, Enguang; Ma, Xingzhe; Lu, Yong; Yang, Maojie; Wang, Qiang; Xue, Gang; Qian, Jianfei; Wang, Siqing; Yi, Qing

2018-01-01

Tumor-specific CD4+ T helper 9 (TH9) cells, so-called because of their production of the cytokine interleukin-9 (IL-9), are a powerful effector T cell subset for cancer immunotherapy. We found that pretreatment of naïve CD4+ T cells with IL-7 further enhanced their differentiation into TH9 cells and augmented their antitumor activity. IL-7 markedly increased the abundance of the histone acetyltransferase p300 by activating the STAT5 and PI3K-AKT-mTOR signaling pathways and promoting the acetylation of histones at the Il9 promoter. As a result, the transcriptional regulator Foxo1 was dephosphorylated and translocated to the nucleus, bound to the Il9 promoter, and induced the production of IL-9 protein. In contrast, Foxp1, which bound to the Il9 promoter in naïve CD4+ T cells and inhibited Il9 expression, was outcompeted for binding to the Il9 promoter by Foxo1 and translocated to the cytoplasm. Furthermore, forced expression of Foxo1 or a deficiency in Foxp1 in CD4+ T cells markedly increased the production of IL-9, whereas a deficiency in Foxo1 inhibited the ability of IL-7 to enhance the differentiation and antitumor activity of TH9 cells. Thus, we identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity, which may provide potential targets for cancer immunotherapy. PMID:29018172

Objective Oriented Design of Architecture for TH System Safety Analysis Code and Verification

Energy Technology Data Exchange (ETDEWEB)

Chung, Bub Dong

2008-03-15

In this work, objective oriented design of generic system analysis code has been tried based on the previous works in KAERI for two phase three field Pilot code. It has been performed to implement of input and output design, TH solver, component model, special TH models, heat structure solver, general table, trip and control, and on-line graphics. All essential features for system analysis has been designed and implemented in the final product SYSTF code. The computer language C was used for implementation in the Visual studio 2008 IDE (Integrated Development Environment) since it has easier and lighter than C++ feature. The code has simple and essential features of models and correlation, special component, special TH model and heat structure model. However the input features is able to simulate the various scenarios, such as steady state, non LOCA transient and LOCA accident. The structure validity has been tested through the various verification tests and it has been shown that the developed code can treat the non LOCA and LOCA simulation. However more detailed design and implementation of models are required to get the physical validity of SYSTF code simulation.

Objective Oriented Design of Architecture for TH System Safety Analysis Code and Verification

International Nuclear Information System (INIS)

Chung, Bub Dong

2008-03-01

In this work, objective oriented design of generic system analysis code has been tried based on the previous works in KAERI for two phase three field Pilot code. It has been performed to implement of input and output design, TH solver, component model, special TH models, heat structure solver, general table, trip and control, and on-line graphics. All essential features for system analysis has been designed and implemented in the final product SYSTF code. The computer language C was used for implementation in the Visual studio 2008 IDE (Integrated Development Environment) since it has easier and lighter than C++ feature. The code has simple and essential features of models and correlation, special component, special TH model and heat structure model. However the input features is able to simulate the various scenarios, such as steady state, non LOCA transient and LOCA accident. The structure validity has been tested through the various verification tests and it has been shown that the developed code can treat the non LOCA and LOCA simulation. However more detailed design and implementation of models are required to get the physical validity of SYSTF code simulation

16th International Conference on Intelligent Systems Design and Applications

CERN Document Server

Abraham, Ajith; Gamboa, Dorabela; Novais, Paulo

2017-01-01

This book comprises selected papers from the 16th International Conference on Intelligent Systems Design and Applications (ISDA’16), which was held in Porto, Portugal from December 1 to16, 2016. ISDA 2016 was jointly organized by the Portugual-based Instituto Superior de Engenharia do Porto and the US-based Machine Intelligence Research Labs (MIR Labs) to serve as a forum for the dissemination of state-of-the-art research and development of intelligent systems, intelligent technologies, and applications. The papers included address a wide variety of themes ranging from theories to applications of intelligent systems and computational intelligence area and provide a valuable resource for students and researchers in academia and industry alike. .

An integrated automatic system to evaluate U and Th dynamic lixiviation from solid matrices, and to extract/pre-concentrate leached analytes previous ICP-MS detection.

Science.gov (United States)

Ceballos, Melisa Rodas; García-Tenorio, Rafael; Estela, José Manuel; Cerdà, Víctor; Ferrer, Laura

2017-12-01

Leached fractions of U and Th from different environmental solid matrices were evaluated by an automatic system enabling the on-line lixiviation and extraction/pre-concentration of these two elements previous ICP-MS detection. UTEVA resin was used as selective extraction material. Ten leached fraction, using artificial rainwater (pH 5.4) as leaching agent, and a residual fraction were analyzed for each sample, allowing the study of behavior of U and Th in dynamic lixiviation conditions. Multivariate techniques have been employed for the efficient optimization of the independent variables that affect the lixiviation process. The system reached LODs of 0.1 and 0.7ngkg -1 of U and Th, respectively. The method was satisfactorily validated for three solid matrices, by the analysis of a soil reference material (IAEA-375), a certified sediment reference material (BCR- 320R) and a phosphogypsum reference material (MatControl CSN-CIEMAT 2008). Besides, environmental samples were analyzed, showing a similar behavior, i.e. the content of radionuclides decreases with the successive extractions. In all cases, the accumulative leached fraction of U and Th for different solid matrices studied (soil, sediment and phosphogypsum) were extremely low, up to 0.05% and 0.005% of U and Th, respectively. However, a great variability was observed in terms of mass concentration released, e.g. between 44 and 13,967ngUkg -1 . Copyright © 2017 Elsevier B.V. All rights reserved.

Two (multi point nonlinear Lyapunov systems associated with an n th order nonlinear system of differential equations – existence and uniqueness

Directory of Open Access Journals (Sweden)

Murty K. N.

2000-01-01

Full Text Available This paper presents a criterion for the existence and uniqueness of solutions to two and multipoint boundary value problems associated with an n th order nonlinear Lyapunov system. A variation of parameters formula is developed and used as a tool to obtain existence and uniqueness. We discuss solution of the second order problem by the ADI method and develop a fixed point method to find the general solution of the n th order Lyapunov system. The results of Barnett (SIAM J. Appl. Anal. 24(1, 1973 are a particular case.

Crystal structures of Th(OH)PO4, U(OH)PO4 and Th2O(PO4)2. Condensation mechanism of M(IV)(OH)PO4 (M= Th, U) into M2O(PO4)2

International Nuclear Information System (INIS)

Dacheux, N.; Clavier, N.; Wallez, G.; Quarton, M.

2007-01-01

Three new crystal structures, isotypic with β-Zr 2 O(PO 4 ) 2 , have been resolved by the Rietveld method. All crystallize with an orthorhombic cell (S.G.: Cmca) with a = 7.1393(2) Angstroms, b = 9.2641(2) Angstroms, c 12.5262(4) Angstroms, V = 828.46(4) (Angstroms) 3 and Z = 8 for Th(OH)PO 4 ; a = 7.0100(2) Angstroms, b = 9.1200(2) Angstroms, c = 12.3665(3) Angstroms, V 790.60(4) (Angstroms) 3 and Z = 8 for U(OH)PO 4 ; a 7.1691(3) Angstroms, b 9.2388(4) Angstroms, c = 12.8204(7) Angstroms, V 849.15(7) (Angstroms) 3 and Z = 4 for Th 2 O(PO 4 ) 2 . By heating, the M(OH)PO 4 (M Th, U) compounds condense topotactically into M 2 O(PO 4 ) 2 , with a change of the environment of the tetravalent cation that lowers from 8 to 7 oxygen atoms. The lower stability of Th 2 O(PO 4 ) 2 compared to that of U 2 O(PO 4 ) 2 seems to result from this unusual environment for tetravalent thorium. (authors)

44th Journées des Actinides and 10th SPCA. Scientific Programme and Abstracts

International Nuclear Information System (INIS)

2014-01-01

In the opening Session for the 10th SPCA the program of the school will be presented.The sessions of the 10th SPCA are: Physics, Chemistry,Theory, electronic structure,Nuclear forensics, Measuring systems. While the 10th SPCA lectures on crystallography, Physics, Chemistry and basics of actinides research

The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP.

Science.gov (United States)

Takahashi, Noriyuki; Saitoh, Takayuki; Gotoh, Nanami; Nitta, Yasuhiro; Alkebsi, Lobna; Kasamatsu, Tetsuhiro; Minato, Yusuke; Yokohama, Akihiko; Tsukamoto, Norifumi; Handa, Hiroshi; Murakami, Hirokazu

2017-05-16

T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional polymorphisms on both susceptibility to, and severity of, cITP. We analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, and IL-4Rα Q576R polymorphisms in 126 cITP patients (male/female: 34/92; median age: 47.7 years) and 202 healthy control donors. Genotyping was determined by PCR and direct sequencing. The Th1/Th2 ratio was detected in peripheral blood mononuclear cells via flow cytometry. cITP patients had a higher frequency of the IL-4Rα 576 non-QQ genotype compared to healthy subjects (P = 0.04). cITP patients with the IFN-γ +874 non-AA genotype (high expression type) showed more severe thrombocytopenia than those with the AA genotype (P Th1/Th2 ratio than control patients (P Th1/Th2 ratio (P Th1/Th2 increase the susceptibility to, and severity of, chronic ITP.

5th Total System Performance Assessment Workshop

International Nuclear Information System (INIS)

Hwang, Yong Soo; Lee, Youn Myoung; Kang, Chul Hyung; Lee, Sung Ho

2009-07-01

Research items on safety assessment of high-level waste repository have been proposed by external invited experts outside KAERI and discussed extensively during the annual 5th performance assessment workshop prepared by safety assessment group in KAERI. This could be useful to set up R and D plans necessary for the next phase of mid- and long-term reaserch area regarding the safety assessment of high-level waste repository. Through the research and the presentation, HLW-related research and development area including such specific research items as current status of HLW safety assessment research, current requirement for the licensing of the repository system, priority on research area, data base building for the safety assessment, source-term modeling as well as safety case, among many others, have been discussed and summarized

Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation.

Science.gov (United States)

Sido, Jessica M; Jackson, Austin R; Nagarkatti, Prakash S; Nagarkatti, Mitzi

2016-09-01

∆(9)-Tetrahydrocannabinol (THC) is one of the major bioactive cannabinoids derived from the Cannabis sativa plant and is known for its anti-inflammatory properties. Delayed-type hypersensitivity (DTH) is driven by proinflammatory T helper cells including the classic inflammatory Th1 lineage as well as the more recently discovered Th17 lineage. In the current study, we investigated whether THC can alter the induction of Th1/Th17 cells involved in mBSA-induced DTH response. THC treatment (20 mg/kg) of C57BL/6 mice with DTH caused decreased swelling and infiltration of immune cells at the site of antigen rechallenge. Additionally, THC treatment decreased lymphocyte activation as well as Th1/Th17 lineage commitment, including reduced lineage-specific transcription factors and cytokines. Interestingly, while DTH caused an overexpression of miR-21, which increases Th17 differentiation via SMAD7 inhibition, and downregulation of miR-29b, an IFN-γ inhibitor, THC treatment reversed this microRNA (miR) dysregulation. Furthermore, when we transfected primary cells from DTH mice with miR-21 inhibitor or miR-29b mimic, as seen with THC treatment, the expression of target gene message was directly impacted increasing SMAD7 and decreasing IFN-γ expression, respectively. In summary, the current study suggests that THC treatment during DTH response can simultaneously inhibit Th1/Th17 activation via regulation of microRNA (miRNA) expression. • THC treatment inhibits simultaneous Th1/Th17 driven inflammation. • THC treatment corrects DTH-mediated microRNA dysregulation. • THC treatment regulates proinflammatory cytokines and transcription factors.

The 17th International Conference on Biomedical Engineering

CERN Document Server

Lim, Chwee; Leo, Hwa

2017-01-01

This volume presents the proceedings of the 16th ICMBE held from 4th to 7th December 2016, Singapore. Topics of the proceedings include 6 tracks: BioImaging and BioSignals, Bio-Micro/Nano Technologies BioRobotics and Medical Devices, Biomaterials and Regenerative Medicine.- BioMechanics and Mechanobiology., Engineering/Synthetic Biology.

Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease.

Science.gov (United States)

Imperatore, Nicola; Rispo, Antonio; Capone, Pietro; Donetto, Sara; De Palma, Giovanni Domenico; Gerbino, Nicolò; Rea, Matilde; Caporaso, Nicola; Tortora, Raffaella

2016-07-01

Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). To evaluate: (1) the prevalence of IMD at the time of and after CD diagnosis; (2) a possible change in immune response to gluten free diet (GFD); (3) the potential role of GFD in reducing and/or preventing IMD in CD. Prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p=0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant "switch" from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p<0.01; OR 1.9). The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Th isotopes in the Santa Monica basin: temporal variation, long-term mass balance and model rate constants

International Nuclear Information System (INIS)

Huh, Chih-An

1995-01-01

Distribution and flux of 234 Th, 232 Th and 230 Th in the water column of central Santa Monica basin observed over a period of seven years show seasonal and interannual variabilities. A steady-state model is applied to the integrated data to calculate long term average flux and model rate constants of Th isotopes. Mass balance calculations show that the basin acts like a closed system for short-lived 234 Th, but not for the long-lived isotopes 230 Th and 232 Th. Most 230 Th in the basin is transported from elsewhere. Of the incoming Th, 40-55% of the 230 Th and 14-26% of the 232 Th enter the surface water in dissolved form. In the upper 100m, the residence time of dissolved Th with respect to adsorption onto suspended particulates, 70-80 days, is about one order of magnitude higher than the residence time of suspended particles with respect to aggregation into sinking particles, 7-10 days. (author)

The Moderating Role of Popular Peers’ Achievement Goals in 5th- and 6th- graders Achievement-related Friendships : A Social Network Analysis

NARCIS (Netherlands)

Wijnen, A.M.; Ryan, Allison; Harakeh, Z.; Shin, Huiyoung; Vollebergh, W.A.M.

This research investigated whether classroom-based peer norms for achievement goals moderate friendship selection, maintenance and influence processes related to academic achievement in 46 5th and 6th grade classrooms (N = 901, 58.7% 5th grade students, 48.5% boys). A distinction was made between

Extraction of Th and U from Swiss granites

International Nuclear Information System (INIS)

Bajo, C.

1980-12-01

The extraction, at the laboratory level, of U and Th from Swiss granites is discussed. The Mittagfluh, Bergell and Rotondo granites and the Giuv syenite offered a wide range of U and Th concentrations; 7.7 to 20.0 ppm U and 25.5 to 67.0 ppm Th. U and Th were determined in the leach solutions by the fission track method and by spectrophotometry, respectively. Samples containing less than 0.3 μg U and 4 μg Th, could be measured with an accuracy of 10% for U and 5% for Th. Leach tests were performed during which the following parameters were varied: granite-type, grain size, acid-type, acid concentration, temperature and time. There were very great leaching differences between the granites studied. Temperature was the most important parameter. Sharp differences in extraction occurred between 20 0 C, 50 0 C and 80 0 C. At 80 0 C, more than 85% U and Th were extracted. The extraction curve (percent extracted as a function of time) of aliquots sampled after 1, 2, 4, 8, 12 and 24 hours showed a plateau after 8 hours. The half life of the reaction was between one and two hours. As a general rule, Th was better extracted than U. (Auth.)

High-density fluid-perturbation theory based on an inverse 12th-power hard-sphere reference system

International Nuclear Information System (INIS)

Ross, M.

1979-01-01

A variational theory is developed that is accurate at normal liquid densities and densities up to 4 times that of the argon triple point. This theory uses the inverse 12th-power potential as a reference system. The properties of this reference system are expressed in terms of hard-sphere packing fractions by using a modified form of hard-space variational theory. As a result of this ''bootstrapping,'' a variational procedure may be followed that employs the inverse 12th-power system as a reference but uses the hard-sphere packing fraction as the scaling parameter with which to minimize the Helmholtz free energy

7th International Conference on Knowledge Management in Organizations (KMO)

CERN Document Server

Herrera, Francisco; Pérez, Javier; Rodríguez, Juan; 7th International Conference on Knowledge Management in Organizations: Service and Cloud Computing

2013-01-01

The seventh International Conference on Knowledge Management in Organizations (KMO) brings together researchers and developers from industry and the academic world to report on the latest scientific and technical advances on knowledge management in organisations.   KMO 2012 provides an international forum for authors to present and discuss research focused on the role of knowledge management for innovative services in industries, to shed light on recent advances in cloud computing for KM as well as to identify future directions for researching the role of knowledge management in service innovation and how cloud computing can be used to address many of the issues currently facing KM in academia and industrial sectors. The conference took place at Salamanca in Spain on the 11th-13th July in 2012.

Intrinsic renal cells induce lymphocytosis of Th22 cells from IgA nephropathy patients through B7-CTLA-4 and CCL-CCR pathways.

Science.gov (United States)

Gan, Lu; Zhou, Qiaoling; Li, Xiaozhao; Chen, Chen; Meng, Ting; Pu, Jiaxi; Zhu, Mengyuan; Xiao, Chenggen

2018-04-01

IgA nephropathy (IgAN), the most common glomerulonephritis, has an unclear pathogenesis. The role of Th22 cells, which are intimately related to proteinuria and progression in IgAN, in mediating infection-related IgAN is unclear. This study aimed to characterize the association between intrinsic renal cells (tubular epithelial cells and mesangial cells) and Th22 cells in immune regulation of infection-related IgAN and to elucidate the impact of Th22 lymphocytosis; the proinflammatory cytokines IL-1, IL-6, and TNF-α; and CCL chemokines on kidney fibrosis. Hemolytic streptococcus infection induced an increase in IL-1, IL-6, and TNF-α, resulting in Th22 cell differentiation from T lymphocytes obtained from patients with IgAN, and the CCL20-CCR6, CCL22-CCR4, and/or CCL27-CCR10 axes facilitated Th22 cell chemotaxis. The increased amount of Th22 cells caused an increase in TGF-β1 levels, and anti-CD80, anti-CD86, and CTLA-4Ig treatment reduced TGF-β1 levels by inhibiting Th22 lymphocytosis and secretion of cytokines and chemokines, thus potentially relieving kidney fibrosis. Our data suggest that Th22 cells might be recruited into the kidneys via the CCL20-CCR6, CCL22-CCR4, and/or CCL27-CCR10 axes by mesangial cells and tubular epithelial cells in infection-related IgAN. Th22 cell overrepresentation was attributed to stimulation of the B7-CTLA-4Ig antigen-presenting pathway and IL-1, IL-6, and TNF-α.

Book of abstracts: International Conference on Smart Energy Systems and 4th Generation District Heating

DEFF Research Database (Denmark)

, which takes a sole focus on the electricity sector, the smart energy systems approach includes the entire energy system in its identification of suitable energy infrastructure designs and operation strategies. Focusing solely on the smart electricity grid often leads to the definition of transmission......It is a great pleasure to welcome you to the first International Conference on Smart Energy Systems and 4th Generation District Heating at Aalborg University, Copenhagen Campus on 25-26 August 2015. The conference is organised by the 4DH Strategic Research Centre in collaboration with Aalborg...... University and offers more than 70 presentations in 3 parallel sessions with more than 180 participants from 25 countries around the world. The aim is to present and discuss scientific findings and industrial experiences related to the development of Smart Energy Systems and future 4th Generation District...

36th International Conference on Information Systems Architecture and Technology

CERN Document Server

Grzech, Adam; Świątek, Jerzy; Wilimowska, Zofia

2016-01-01

This four volume set of books constitutes the proceedings of the 36th International Conference Information Systems Architecture and Technology 2015, or ISAT 2015 for short, held on September 20–22, 2015 in Karpacz, Poland. The conference was organized by the Computer Science and Management Systems Departments, Faculty of Computer Science and Management, Wroclaw University of Technology, Poland. The papers included in the proceedings have been subject to a thorough review process by highly qualified peer reviewers. The accepted papers have been grouped into four parts: Part I—addressing topics including, but not limited to, systems analysis and modeling, methods for managing complex planning environment and insights from Big Data research projects. Part II—discoursing about topics including, but not limited to, Web systems, computer networks, distributed computing, and multi-agent systems and Internet of Things. Part III—discussing topics including, but not limited to, mobile and Service Oriented Archi...

A VUV detection system for the direct photonic identification of the first excited isomeric state of "2"2"9Th

International Nuclear Information System (INIS)

Seiferle, B.; Von der Wense, L.; Thirolf, P.G.; Laatiaoui, M.

2016-01-01

With an expected energy of 7.6(5) eV, "2"2"9Th possesses the lowest excited nuclear state in the landscape of all presently known nuclei. The energy corresponds to a wavelength of about 160 nm and would conceptually allow for an optical laser excitation of a nuclear transition. We report on a VUV optical detection system that was designed for the direct detection of the isomeric ground-state transition of "2"2"9Th. "2"2"9"("m") Th ions originating from a "2"3"3U α-recoil source are collected on a micro electrode that is placed in the focus of an annular parabolic mirror. The latter is used to parallelize the UV fluorescence that may emerge from the isomeric ground-state transition of "2"2"9Th. The parallelized light is then focused by a second annular parabolic mirror onto a CsI-coated position-sensitive MCP detector behind the mirror exit. To achieve a high signal-to-background ratio, a small spot size on the MCP detector needs to be achieved. Besides extensive ray-tracing simulations of the optical setup, we present a procedure for its alignment, as well as test measurements using a D_2 lamp, where a focal-spot size of ∼100 μm has been achieved. Assuming a purely photonic decay, a signal-to-background ratio of ∼7000:1 could be achieved. (authors)

Results of 7th regular inspection of No.1 plant in Oi Power Station, Kansai Electric Power Co., Inc

International Nuclear Information System (INIS)

1989-01-01

The 7th regular inspection of No.1 plant in Oi Power Station was carried out from December 25, 1987 to July 15, 1988. The parallel operation was resumed on June 23, 1988, 182 days after the start of the inspection. The facilities to be inspected were the reactor proper, reactor cooling system, measurement and control system, fuel facilities, radiation control facilities, waste facilities, reactor containment installation and emergency power generation system. On these facilities to be inspected, the appearance, disassembling, leak, function, performance and other inspections were carried out, and as the results, a part of the fitting of a water chamber partition cover for a steam generator broke off, significant signals were observed in 936 heating tubes of steam generators, 72 bolts for fixing the blade of a primary coolant pump were damaged, and leak was found in two fuel assemblies. The works related to this regular inspection were accomplished within the range of allowable radiation dose based on the relevant laws. The main reconstruction works carried out during the period of this regular inspection were the use of the fuel containing gadolinia, the removal of a thermometer bypass piping and the repair of defective steam generator tubes. (K.I.)

Thermodynamic assessment of the LiF–ThF{sub 4}–PuF{sub 3}–UF{sub 4} system

Energy Technology Data Exchange (ETDEWEB)

Capelli, E. [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe (Germany); Department of Radiation Science and Technology, Faculty of Applied Physics, Delft University of Technology, Delft 2629JB (Netherlands); Beneš, O., E-mail: ondrej.benes@ec.europa.eu [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe (Germany); Konings, R.J.M. [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe (Germany); Department of Radiation Science and Technology, Faculty of Applied Physics, Delft University of Technology, Delft 2629JB (Netherlands)

2015-07-15

The LiF–ThF{sub 4}–PuF{sub 3}–UF{sub 4} system is the reference salt mixture considered for the Molten Salt Fast Reactor (MSFR) concept started with PuF{sub 3}. In order to obtain the complete thermodynamic description of this quaternary system, two binary systems (ThF{sub 4}–PuF{sub 3} and UF{sub 4}–PuF{sub 3}) and two ternary systems (LiF–ThF{sub 4}–PuF{sub 3} and LiF–UF{sub 4}–PuF{sub 3}) have been assessed for the first time. The similarities between CeF{sub 3}/PuF{sub 3} and ThF{sub 4}/UF{sub 4} compounds have been taken into account for the presented optimization as well as in the experimental measurements performed, which have confirmed the temperatures predicted by the model. Moreover, the experimental results and the thermodynamic database developed have been used to identify potential compositions for the MSFR fuel and to evaluate the influence of partial substitution of ThF{sub 4} by UF{sub 4} in the salt.

The institutions forming the socioeconomic structure of Turkish private enterprises between the 13th and the 19th centuries: Akhism, the Lonca system and the Gedik system

Directory of Open Access Journals (Sweden)

Mehmet Özbirecikli

2010-12-01

principios éticos de la vida empresarial, en esencia, son los mismos. Dentro de este contexto, nos atrevemos a sugerir que las raíces del código ético de la vida empresarial turca se retrotraen en la historia a hace más de 800 años. Además, la similitud entre el funcionamiento presente y pasado indica que el origen de la formación de los aprendices para las empresas turcas tiene, igualmente, más de 800 años de historia.This study investigates three institutions forming the socioeconomic structure of Turkish private enterprises between the 13th and 19th Centuries: Akhism (13th-16th century, the Lonca System (the Guilds (16th-18th century, and the Gedik (Monopoly System (18th-20th century. The study particularly focuses on the social and economic rules, vocational training process, and organizational structure of the said institutions in order to discuss the effects of the socioeconomic structure of Turkish enterprises on economic and social development of private enterprises. The study also struggles to link between the relevant current applications and the applications in the past such as the social rules and vocational training. From economic point of view, both the statist structure of the State and the economic rules of the institutions herein caused private enterprises to remain small, and prevented them from having a competitive environment and having capital accumulation. As a result, enterprises could not benefit from new production techniques and the Turkish enterprise mentality fell behind modern developments. On the other hand, although these three systems were completely abolished in the early 20th Century, it is seen that especially traces of the Akhism and Lonca systems have still been surviving. Both the most of rules of Akhism and some of the duties of the board of directors of Lonca such as keeping moral standards of production and trade remind us of professional code of ethics of today’s modern business life. In other saying, there was code of

Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

Science.gov (United States)

Chen, Renxiang; Wang, Yi-Wen; Fornace, Albert J; Li, Heng-Hong

2016-12-01

Two major CD4 + T-helper (Th) lineages are Th1 and Th2, and well balanced Th1/Th2 responses are essential for immune function. In previously published studies, it was reported that radiation induces a Th1/Th2 immune imbalance toward a Th2-dominant direction, and this imbalance may contribute to postirradiation immune dysfunction. The polarization of Th cells is driven by the cytokine milieu and controlled by intracellular regulatory pathways that respond to cytokine signaling. It is widely accepted that radiation induces cytokine aberration, however, the precise alterations of cytokines in various tissue environments have been difficult to evaluate. In addition, the effects of radiation on the intrinsic functions of Th cells remain uncharacterized. Therefore, how radiation affects Th1/Th2 balance remains somewhat unclear. To address this, we investigated the changes in the polarization capability of Th cells by isolating them from mice previously exposed to radiation and assessing the cells in an established in vitro Th polarization system. Our novel results demonstrate that prior exposure to radiation led to the persistent aberration of the inherent capability of Th cells to differentiate into Th1 and Th2 lineages. The parallel changes in expression of Th1-specific master transcription factors and the key genes in metabolic reprograming indicated that radiation affects the core components in Th1 polarization. While Th1 differentiation was impaired after irradiation, little adverse effect was observed in Th2 differentiation; both of these findings contribute to the known phenotypes of Th1/Th2 imbalance caused by radiation.

49 CFR 570.7 - Steering systems.

Science.gov (United States)

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Steering systems. 570.7 Section 570.7... Pounds or Less § 570.7 Steering systems. (a) System play. Lash or free play in the steering system shall... in the steering system. Table 1—Steering System Free Play Values Steering wheel diameter (inches...

15th IEEE International Conference on Intelligent Engineering Systems

CERN Document Server

Živčák, Jozef; Aspects of Computational Intelligence Theory and Applications

2013-01-01

This volume covers the state-of-the art of the research and development in various aspects of computational intelligence and gives some perspective directions of development. Except the traditional engineering areas that contain theoretical knowledge, applications, designs and projects, the book includes the area of use of computational intelligence in biomedical engineering. „Aspects of Computational Intelligence: Theory and Applications” is a compilation of carefully selected extended papers written on the basis of original contributions presented at the 15th IEEE International Conference on Intelligent Engineering Systems 2011, INES 2011 held at June 23.-26. 2011 in AquaCity Poprad, Slovakia.    

7th Patras workshop on axions, WIMPs and WISPs (PATRAS 2011). Proceedings

International Nuclear Information System (INIS)

Zioutas, Konstantin; Schumann, Marc

2011-12-01

The year 2011 was an exciting period to work on the ''dark side'' of the Universe. Several experimental claims of the direct detection of WIMP dark matter were challenged by the restrictive limits of several others. Dedicated experiments searching for axions, another well motivated dark matter candidate, and for axion-like particles continued to improve their limits and got an additional boost by puzzling astrophysical observations and new developments in theory. The LHC collected an unexpectedly large amount of data and started to produce results at an amazing speed. And finally, this year's Nobel price of physics was awarded to the observation of the accelerating expansion of the Universe, an effect which might be related to dark energy, whose nature remain among the biggest mysteries in physics. These exciting topics and many more important aspects of particle- and astroparticle physics were discussed between experimentalists and theorists at the 7th Patras Workshop on Axions, WIMPs, and WISPs. The workshop took place from June 27 - July 1, 2011, in the Royal Myconian and Myconian Imperial Resorts Hotels on the Greek island of Mykonos. As in the previous years, it was a very fruitful and lively meeting in an inspiring and open atmosphere, which allowed for many open and constructive discussions also on controversial topics. The scientific exchange, the beautiful scenery of the island, the venue itself, the food, an excursion to the ancient ruins of Delos, and finally an amazing conference dinner made this meeting really unique. The ''spirit'' of the workshop and its atmosphere cannot be brought to paper, but many of its scientific highlights are collected in these proceedings. We are looking forward to the 8th Patras Workshop, which will be held in Chicago (USA) July 18-22, 2012. It will be organized jointly by our US colleagues Andrei Afanasev (JLAB), Oliver Baker (Yale), and William Wester (FNAL).

11th International Conference on Dependability and Complex Systems

CERN Document Server

Mazurkiewicz, Jacek; Sugier, Jarosław; Walkowiak, Tomasz; Kacprzyk, Janusz

2016-01-01

These proceedings present the results of the Eleventh International Conference on Dependability and Complex Systems DepCoS-RELCOMEX which took place in a picturesque Brunów Palace in Poland from 27th June to 1st July, 2016. DepCoS-RELCOMEX is a series of international conferences organized annually by Department of Computer Engineering of Wrocław University of Science and Technology since 2006. The roots of the series go as far back as to the seventies of the previous century – the first RELCOMEX conference took place in 1977 – and now its main aim is to promote a multi-disciplinary approach to dependability problems in theory and engineering practice of complex systems. Complex systems, nowadays most often computer-based and distributed, are built upon a variety of technical, information, software and human resources. The challenges in their design, analysis and maintenance not only originate from the involved technical and organizational structures but also from the complexity of the information proce...

Contributions to 30th European Physical Society conference on controlled fusion and plasma physics (St. Petersburg, Russia, 7-11 July 2003) from NIFS

International Nuclear Information System (INIS)

2003-08-01

25 contributed papers to the 30th European Physical Society Conference on Controlled Fusion and Plasma Physics (St. Petersburg, Russia, 7-11 July 2003) from the activity of NIFS are collected in this report. (author)

7th Expert meeting radiation protection. International developments, waste management, challenges for the radiation protection in aging nuclear installations

International Nuclear Information System (INIS)

2010-01-01

The proceedings of the 7th Expert meeting on radiation protection include contributions to the following topics: nuclear power and public opinion, IAEA safety standards, ISOE - information system on occupational exposure, European harmonization of the radiation protection education, WANO - challenges and results, CTBTO's global radiation measurement network, state of final radioactive waste disposal in Germany and worldwide, radioactive waste management and disposal in French NPPs, preparedness for final waste disposal in Schacht Konrad, actualization of the transport study Konrad, transport of NPPs' operational radioactive waste and waste from decommissioned reactor demolition to the final repository Konrad, qualification of radioactive waste casks for the final repository Konrad, radioactive waste disposal management concept in Switzerland, aging management and radiation protection, decontamination as effective measure for dose rate reduction - long-term and sustainable dose rate reduction by primary circuit decontamination, system and component decontamination for individual and collective dose reduction - practical examples, radiation protection map - electronic assistance for work planning, EPR dismantling already today? radiation protection register 2002-2010 - knowledge based on a decade of radiation monitoring, actual information on radiation protection in medicine, mobile telecommunication - actual research results.

Evolution of the Campanian Ignimbrite Magmatic System II: Trace Element and Th Isotopic Evidence for Open-System Processes

Science.gov (United States)

Bohrson, W. A.; Spera, F. J.; Fowler, S.; Belkin, H.; de Vivo, B.

2005-12-01

The Campanian Ignimbrite, a large volume (~200 km3 DRE) trachytic to phonolitic ignimbrite was deposited at ~39.3 ka and represents the largest of a number of highly explosive volcanic events in the region near Naples, Italy. Thermodynamic modeling of the major element evolution using the MELTS algorithm (see companion contribution by Fowler et al.) provides detailed information about the identity of and changes in proportions of solids along the liquid line of descent during isobaric fractional crystallization. We have derived trace element mass balance equations that explicitly accommodate changing mineral-melt bulk distribution coefficients during crystallization and also simultaneously satisfy energy and major element mass conservation. Although major element patterns are reasonably modeled assuming closed system fractional crystallization, modeling of trace elements that represent a range of behaviors (e.g. Zr, Nb, Th, U, Rb, Sm, Sr) yields trends for closed system fractionation that are distinct from those observed. These results suggest open-system processes were also important in the evolution of the Campanian magmatic system. Th isotope data yield an apparent isochron that is ~20 kyr younger than the age of the deposit, and age-corrected Th isotope data indicate that the magma body was an open-system at the time of eruption. Because open-system processes can profoundly change isotopic characteristics of a magma body, these results illustrate that it is critical to understand the contribution that open-system processes make to silicic magma bodies prior to assigning relevance to age or timescale information derived from isotope systematics. Fluid-magma interaction has been proposed as a mechanism to change isotopic and elemental characteristics of magma bodies, but an evaluation of the mass and thermal constraints on such a process suggest large-scale fluid-melt interaction at liquidus temperatures is unlikely. In the case of the magma body associated with

7th International Workshop on Application of Lasers in Atomic Nuclei Research “Nuclear Ground and Isometric State Properties”

CERN Document Server

Błaszczak, Z; Marinova, K; LASER 2006

2007-01-01

7th International Workshop on Application of Lasers in Atomic Nuclei Research, LASER 2004, held in Poznan, Poland, May 29-June 01, 2006 Researchers and PhD students interested in recent results in the nuclear structure investigation by laser spectroscopy, the progress of the experimental technique and the future developments in the field will find this volume indispensable. Reprinted from Hyperfine Interactions (HYPE) Volume ???

2016 37th International Conference Information Systems Architecture and Technology

CERN Document Server

Grzech, Adam; Świątek, Jerzy; Wilimowska, Zofia

2017-01-01

This four volume set of books constitutes the proceedings of the 2016 37th International Conference Information Systems Architecture and Technology (ISAT), or ISAT 2016 for short, held on September 18–20, 2016 in Karpacz, Poland. The conference was organized by the Department of Management Systems and the Department of Computer Science, Wrocław University of Science and Technology, Poland. The papers included in the proceedings have been subject to a thorough review process by highly qualified peer reviewers. The accepted papers have been grouped into four parts: Part I—addressing topics including, but not limited to, systems analysis and modeling, methods for managing complex planning environment and insights from Big Data research projects. Part II—discoursing about topics including, but not limited to, Web systems, computer networks, distributed computing, and mulit-agent systems and Internet of Things. Part III—discussing topics including, but not limited to, mobile and Service Oriented Architect...

Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus.

Science.gov (United States)

Tse, Doris B; Young, Bruce K

2012-01-06

If maternal atopy and environmental exposure affect prenatal Th cell development, the maternal and fetal immune systems should display common Th1/Th2 phenotypes. To test this hypothesis, we studied maternal and neonatal blood samples from mothers with total serum IgE ordinate IFN-γ production from paired maternal and fetal mononuclear cells, accompanied by co-ordinate increases in activated CD4+CD69+ cells that display the CCR4+Th2 and CXCR3+ Th1 phenotypes. Maternal and fetal CD4+CXCR3+ T cells were subsequently identified as the major producers of IFN-γ. The data established that a transplacental nexus exists during normal pregnancy and that fetal Th cell responses may be biased by the maternal immune system.

The Effects of Animation Supported 5E Model on Teaching "Indicative and Subjunctive Moods" in 7th Grade Turkish Lesson

Science.gov (United States)

Özcan, Mehmet Fatih; Kiliç, Latife Kirbasoglu

2017-01-01

This study is to investigate the effects of animated 5E method on the success, attitude and opinions towards the course in teaching of "subjunctive and indicative moods" subject of 7th grade Turkish course. The study was conducted with 60 seventh grade students of a state-run secondary school in Palandöken district of Erzurum during the…

Understanding motivation of visitors at dark tourism sites : Case study of August 7th Memorial Park, Kenya

OpenAIRE

Gaya, Esther

2013-01-01

Recently, the fascination of death and disaster has influenced the tourism scene and today, millions of visitors from all over the world travel to sites of death and disaster. This study aims to identify what motivates tourists to visit sites of death and disaster in order to understand better visitor behavior at such sites and specifically the August 7th Memorial Park, Kenya; which was the site of a 1998 terrorist bomb attack that caused the deaths of 218 people and injured thousands more. ...

Control system design for a 100 MW(th) research reactor

International Nuclear Information System (INIS)

Seshadri, S.N.; Ranganath, M.V.; Singh, Manjit.

1983-01-01

This paper presents the computer simulation carried out to evolve a suitable analog controller for a 100 MW(th) heavy water moderated research reactor under construction at Trombay. The control action is based on the average neutron flux in the reactor core and the reactivity is controlled by adjusting the moderator level in the calandria. A dual control scheme controlling the inflow as well as the outflow was adopted in order to fully exploit the capabilities of control elements. For reasons of reliability, the system consists of three identical channels enabling safe operation even under one channel failure. Based on the simulation studies a suitable compensation network was incorporated to achieve satisfactory system response. (author)

A social way to experience a scientific event: Twitter use at the 7th European Public Health Conference.

Science.gov (United States)

Bert, Fabrizio; Zeegers Paget, Dineke; Scaioli, Giacomo

2016-03-01

Many studies have analysed Twitter's use by attendees of scientific meetings and the characteristics of conference-related messages and most active attendees. Despite these previous reports, to date no studies have described the use of Twitter during Public Health conferences. For this reason, we decided to perform an analysis of Twitter's use during the 7th European Public Health (EPH) Conference (Glasgow, November 2014). All the tweets published from 21 July to 2 December 2014 and including the hashtag #ephglasgow were retrieved and much information (author, date, retweets, favourites, mentions, presence of pictures and/or external links, content type and topics) was analysed. A total of 1066 tweets with the hashtag #ephglasgow were retrieved; 86.3% of these were tweeted during the conference. A total of 209 single accounts tweeted, pictures were present in 29.7% tweets while external links were published in 13.8%. Conference speakers were mentioned in around 30% of tweets. Almost 60% of the tweets had a session-related content. Considering only the session-related tweets, one-third had as the main topic 'Health inequalities and migrant and ethnic minority health', while 20% were 'Health policy and health economics' oriented. The results of this study have demonstrated a massive use of Twitter by conference attendees during the 7th EPH conference, and that conference attendees are willing to share quotes and impressions particularly about conference-related topics. It is mandatory for conference organisers to promote online discussion and knowledge dissemination during conferences, especially in the public health field. © 2015 the Nordic Societies of Public Health.

5th CIRP international conference on industrial product-service systems

CERN Document Server

2013-01-01

“An Industrial Product-Service System is characterized by the integrated and mutually  determined planning, development, provision and use of product and service shares including its immanent software components in Business-to-Business applications and represents a knowledge-intensive socio-technical system.” – Meier, Roy, Seliger (2010) Since the first conference in 2009, the CIRP International Conference on Industrial Product-Service Systems has become a well-established international forum for the review and discussion of advances, research results and industrial improvements. Researchers from all over the world have met at previous IPS² conferences in Cranfield (2009), Linköping (2010), Braunschweig (2011) and Tokyo (2012). In 2013, the 5th CIRP International Conference on Industrial Product-Service Systems is held in Bochum. Important topics of IPS² research presented at the conference are: planning and development, sustainability, business models, operation, service engineering, knowledge mana...

9th Asian Conference on Intelligent Information and Database Systems

CERN Document Server

Nguyen, Ngoc; Shirai, Kiyoaki

2017-01-01

This book presents recent research in intelligent information and database systems. The carefully selected contributions were initially accepted for presentation as posters at the 9th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2017) held from to 5 April 2017 in Kanazawa, Japan. While the contributions are of an advanced scientific level, several are accessible for non-expert readers. The book brings together 47 chapters divided into six main parts: • Part I. From Machine Learning to Data Mining. • Part II. Big Data and Collaborative Decision Support Systems, • Part III. Computer Vision Analysis, Detection, Tracking and Recognition, • Part IV. Data-Intensive Text Processing, • Part V. Innovations in Web and Internet Technologies, and • Part VI. New Methods and Applications in Information and Software Engineering. The book is an excellent resource for researchers and those working in algorithmics, artificial and computational intelligence, collaborative systems, decisio...

19. srednjeevropska konferenca o informatiki in inteligentnih sistemih = 19th Central European Conference on Information and Intelligent Systems

Directory of Open Access Journals (Sweden)

Armand Faganel

2008-12-01

Full Text Available The aim of the paper is to present the 19th Central European Conference on Information and Intelligent Systems, CECIIS 2008, which took place between 24th and 26th September in Varaždin and was organised by the Faculty of Organisation and Informatics in Varaždin. The central theme of this year’s conference was e-government. During those 3 days, 250 participants could attend presentations of 90 scientific and professional works in 15 sections and 9 invited lectures on the newest trends in the area of information and communication technology management, information technologies, security of information systems, multimedia systems, strategic planning of information systems, education for information society. Two other parallel events were held within the international conference, namely the workshop ‘Activities towards ICT professionalism’ and a round table on the subject ‘Competences of ICT Professionals’. Experts in the field of human resources, leaders of information centres and managers of the leading Croatian companies participated in the latter.

MOUNTAIN-SCALE COUPLED PROCESSES (TH/THC/THM) MODELS

International Nuclear Information System (INIS)

Y.S. Wu

2005-01-01

This report documents the development and validation of the mountain-scale thermal-hydrologic (TH), thermal-hydrologic-chemical (THC), and thermal-hydrologic-mechanical (THM) models. These models provide technical support for screening of features, events, and processes (FEPs) related to the effects of coupled TH/THC/THM processes on mountain-scale unsaturated zone (UZ) and saturated zone (SZ) flow at Yucca Mountain, Nevada (BSC 2005 [DIRS 174842], Section 2.1.1.1). The purpose and validation criteria for these models are specified in ''Technical Work Plan for: Near-Field Environment and Transport: Coupled Processes (Mountain-Scale TH/THC/THM, Drift-Scale THC Seepage, and Drift-Scale Abstraction) Model Report Integration'' (BSC 2005 [DIRS 174842]). Model results are used to support exclusion of certain FEPs from the total system performance assessment for the license application (TSPA-LA) model on the basis of low consequence, consistent with the requirements of 10 CFR 63.342 [DIRS 173273]. Outputs from this report are not direct feeds to the TSPA-LA. All the FEPs related to the effects of coupled TH/THC/THM processes on mountain-scale UZ and SZ flow are discussed in Sections 6 and 7 of this report. The mountain-scale coupled TH/THC/THM processes models numerically simulate the impact of nuclear waste heat release on the natural hydrogeological system, including a representation of heat-driven processes occurring in the far field. The mountain-scale TH simulations provide predictions for thermally affected liquid saturation, gas- and liquid-phase fluxes, and water and rock temperature (together called the flow fields). The main focus of the TH model is to predict the changes in water flux driven by evaporation/condensation processes, and drainage between drifts. The TH model captures mountain-scale three-dimensional flow effects, including lateral diversion and mountain-scale flow patterns. The mountain-scale THC model evaluates TH effects on water and gas

MOUNTAIN-SCALE COUPLED PROCESSES (TH/THC/THM)MODELS

Energy Technology Data Exchange (ETDEWEB)

Y.S. Wu

2005-08-24

This report documents the development and validation of the mountain-scale thermal-hydrologic (TH), thermal-hydrologic-chemical (THC), and thermal-hydrologic-mechanical (THM) models. These models provide technical support for screening of features, events, and processes (FEPs) related to the effects of coupled TH/THC/THM processes on mountain-scale unsaturated zone (UZ) and saturated zone (SZ) flow at Yucca Mountain, Nevada (BSC 2005 [DIRS 174842], Section 2.1.1.1). The purpose and validation criteria for these models are specified in ''Technical Work Plan for: Near-Field Environment and Transport: Coupled Processes (Mountain-Scale TH/THC/THM, Drift-Scale THC Seepage, and Drift-Scale Abstraction) Model Report Integration'' (BSC 2005 [DIRS 174842]). Model results are used to support exclusion of certain FEPs from the total system performance assessment for the license application (TSPA-LA) model on the basis of low consequence, consistent with the requirements of 10 CFR 63.342 [DIRS 173273]. Outputs from this report are not direct feeds to the TSPA-LA. All the FEPs related to the effects of coupled TH/THC/THM processes on mountain-scale UZ and SZ flow are discussed in Sections 6 and 7 of this report. The mountain-scale coupled TH/THC/THM processes models numerically simulate the impact of nuclear waste heat release on the natural hydrogeological system, including a representation of heat-driven processes occurring in the far field. The mountain-scale TH simulations provide predictions for thermally affected liquid saturation, gas- and liquid-phase fluxes, and water and rock temperature (together called the flow fields). The main focus of the TH model is to predict the changes in water flux driven by evaporation/condensation processes, and drainage between drifts. The TH model captures mountain-scale three-dimensional flow effects, including lateral diversion and mountain-scale flow patterns. The mountain-scale THC model evaluates TH effects on

CCR6+ Th cell distribution differentiates systemic lupus erythematosus patients based on anti-dsDNA antibody status.

Science.gov (United States)

Zhong, Wei; Jiang, Zhenyu; Wu, Jiang; Jiang, Yanfang; Zhao, Ling

2018-01-01

Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA + SLE patients display a worse disease course. The generation of these pathogenic anti-DNAs has been attributed to the interaction between aberrant T helper (Th) cells and autoimmune B cells. Thus, in this study we have investigated whether CCR6 + Th cells have the ability to differentiate SLE patients based on anti-DNA status, and if their distribution has any correlation with disease activity. We recruited 25 anti-DNA + and 25 anti-DNA - treatment-naive onset SLE patients, matched for various clinical characteristics in our nested matched case-control study. CCR6 + Th cells and their additional subsets were analyzed in each patient by flow cytometry. Anti-DNA + SLE patients specifically had a higher percentage of Th cells expressing CCR6 and CXCR3. Further analysis of CCR6 + Th cell subsets showed that anti-DNA + SLE patients had elevated proportions of Th9, Th17, Th17.1 and CCR4/CXCR3 double-negative (DN) cells. However, the proportions of CCR6 - Th subsets, including Th1 and Th2 cells, did not show any association with anti-DNA status. Finally, we identified a correlation between CCR6 + Th subsets and clinical indicators, specifically in anti-DNA + SLE patients. Our data indicated that CCR6 + Th cells and their subsets were elevated and correlated with disease activity in anti-DNA + SLE patients. We speculated that CCR6 + Th cells may contribute to distinct disease severity in anti-DNA + SLE patients.

7th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2015)

CERN Document Server

Nguyen, Ngoc; Batubara, John; New Trends in Intelligent Information and Database Systems

2015-01-01

Intelligent information and database systems are two closely related subfields of modern computer science which have been known for over thirty years. They focus on the integration of artificial intelligence and classic database technologies to create the class of next generation information systems. The book focuses on new trends in intelligent information and database systems and discusses topics addressed to the foundations and principles of data, information, and knowledge models, methodologies for intelligent information and database systems analysis, design, and implementation, their validation, maintenance and evolution. They cover a broad spectrum of research topics discussed both from the practical and theoretical points of view such as: intelligent information retrieval, natural language processing, semantic web, social networks, machine learning, knowledge discovery, data mining, uncertainty management and reasoning under uncertainty, intelligent optimization techniques in information systems, secu...

Accelerator-Driven Systems - the iThEC strategy

International Nuclear Information System (INIS)

Revol, Jean-Pierre

2015-01-01

The International Thorium Energy Committee (iThEC) created in Geneva in 2012 is concerned about the energetic future of our society, which is totally organized on the basis of a fossil fuel economy. This has to change because of obvious geopolitical reasons, because of the impact this economy has on the environment, and because of the rather short time on the human time scale, it will take for fossil fuels to run out. One of the main goals of iThEC is to work on reversing the current negative perception of nuclear energy in Europe, which is the main hurdle to a more serious R and D effort in this field. iThEC provides better information to the public on thorium possibilities, supports thorium ADS technology developments, any R and D regarding thorium, and actively engages the scientific, political and business leadership on the subject

Challenging a dogma; AJCC 8th staging system is not sufficient to predict outcomes of patients with malignant pleural mesothelioma.

Science.gov (United States)

Abdel-Rahman, Omar

2017-11-01

The 8th edition of malignant pleural mesothelioma (MPM) American Joint Committee on Cancer (AJCC) staging system has been published. The current analysis aims to evaluate its performance in a population-based setting among patients recorded within the surveillance, epidemiology and end results (SEER) database. SEER database (2004-2013) has been accessed through SEER*Stat program and AJCC 8th edition stage groups were reconstructed. Survival analyses (overall and cancer-specific) were conducted according to 6th and 8th editions through Kaplan-Meier analysis. Cox-regression multivariate model was also utilized for pair wise comparisons between different prognostic groups for overall and cancer-specific survival. A total of 5382 patients with MPM were identified in the period from 2004 to 2013. According to the 6th edition, significant pair wise P values for overall survival included: IA vs. III (P=0.027); IA vs. IV: P<0.0001; IB vs. IV: P<0.0001; II vs. III: P<0.0001; II vs. IV: P<0.0001; III vs. IV: P<0.0001). According to the 8th edition, significant pair wise P values for overall survival included: all stages vs. IV: P<0.0001; IA vs. II: P=0.046; IA vs. IIIA: P=0.022; IA vs. IIIB: P <0.0001; IB vs. II: P<0.0001; IB vs. IIIB: P<0.0001; II vs. IIIA: P<0.0001; IIIA vs. IIIB: P<0.0001). C-index for 6th edition was 0.539 (SE: 0.008; 95% CI: 0.524-0.555); while C-index for 8th edition was 0.540 (SE: 0.008; 95% CI: 0.525-0.556). Based on the above findings, a simplified staging system was proposed and overall and cancer-specific survivals were evaluated according to the simplified system. For overall and cancer-specific survival assessment, P values for all pair wise comparisons among different stages were significant (<0.01). The prognostic performance of both the 6th and 8th AJCC editions is unsatisfactory; there is a need for a more practical and prognostically relevant staging system for MPM. Copyright © 2017 Elsevier B.V. All rights reserved.

The Use of Monograms on Byzantine Seals in the Early Middle-Ages (6th to 9th Centuries

Directory of Open Access Journals (Sweden)

Werner Seibt

2016-06-01

Full Text Available The paper deals especially with monograms on Byzantine lead seals. The early form was the block monogram, a type used already in Classical times, which came into fashion in the Byzantine world in the 6th or already in the 5th century and remained important till the early 7th century. Such monograms hide normally a name, a title or an office, the Greek ones in genitive, the Latin ones in nominative or genitive. Many of them can be read in different ways. For the double using of parts of letters for other ones the well-known Latin monogram of Theoderich is explained in detail.  But the “typical Byzantine monogram” became the cross monogram, with letters more or less affixed on the arms of a Greek cross. The earliest example stems from a coin of Justinus I, starting 522, quite earlier than Theodora’s monograms on capitals in the Hagia Sophia. These cruciform monograms presented in the beginning also a name, a title or an office, but in the 8th century already often a combination of them; these monograms with prosopographical information stopped in Byzantium at the end of the 8th century.  On the other hand invocative monograms (like Θεοτόκε βοήθει, often with the tetragram τῷ σῷ δούλῳ in the free quarters of the monogram, started around the middle of the 7th century and can be found till the earlier 11th century. The most common ones were collected by V. Laurent – we use this system till today, though there are much more types documented.  An important problem is that sometimes single letters are “hidden” in another letter, e. g. Lambda in Alpha or Delta, Epsilon in a Kappa on the left bar of a cross monogram, Sigma in Epsilon, Sigma in Kappa, Omikron in Rho, etc. In Vienna we developed a special program to solve many monograms. If we bring all the readable letters of a monogram (including the possibly additional ones in an alphabetical order, and do the same with the letters of names, titles and offices

A systems immunology approach identifies the collective impact of 5 miRs in Th2 inflammation.

Science.gov (United States)

Kılıç, Ayşe; Santolini, Marc; Nakano, Taiji; Schiller, Matthias; Teranishi, Mizue; Gellert, Pascal; Ponomareva, Yuliya; Braun, Thomas; Uchida, Shizuka; Weiss, Scott T; Sharma, Amitabh; Renz, Harald

2018-06-07

Allergic asthma is a chronic inflammatory disease dominated by a CD4+ T helper 2 (Th2) cell signature. The immune response amplifies in self-enforcing loops, promoting Th2-driven cellular immunity and leaving the host unable to terminate inflammation. Posttranscriptional mechanisms, including microRNAs (miRs), are pivotal in maintaining immune homeostasis. Since an altered expression of various miRs has been associated with T cell-driven diseases, including asthma, we hypothesized that miRs control mechanisms ensuring Th2 stability and maintenance in the lung. We isolated murine CD4+ Th2 cells from allergic inflamed lungs and profiled gene and miR expression. Instead of focusing on the magnitude of miR differential expression, here we addressed the secondary consequences for the set of molecular interactions in the cell, the interactome. We developed the Impact of Differential Expression Across Layers, a network-based algorithm to prioritize disease-relevant miRs based on the central role of their targets in the molecular interactome. This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype. Overall, a systems biology tool was developed and validated, highlighting the role of miRs in Th2-driven immune response. This result offers potentially novel approaches for therapeutic interventions.

Extended networks, porous sheets, and chiral frameworks. Thorium materials containing mixed geometry anions: Structures and properties of Th(SeO3)(SeO4), Th(IO3)2(SeO4)(H2O)3.H2O, and Th(CrO4)(IO3)2

International Nuclear Information System (INIS)

Sullens, Tyler A.; Almond, Philip M.; Byrd, Jessica A.; Beitz, James V.; Bray, Travis H.; Albrecht-Schmitt, Thomas E.

2006-01-01

Three novel Th(IV) compounds containing heavy oxoanions, Th(SeO 3 )(SeO 4 ) (1), Th(IO 3 ) 2 (SeO 4 )(H 2 O) 3 .H 2 O (2), and Th(CrO 4 )(IO 3 ) 2 (3), have been synthesized under mild hydrothermal conditions. Each of these three distinct structures contain trigonal pyramidal and tetrahedral oxoanions. Compound 1 adopts a three-dimensional structure formed from ThO 9 tricapped trigonal prisms, trigonal pyramidal selenite, SeO 3 2- , anions containing Se(IV), and tetrahedral selenate, SeO 4 2- , anions containing Se(VI). The structure of 2 contains two-dimensional porous sheets and occluded water molecules. The Th centers are found as isolated ThO 9 tricapped trigonal prisms and are bound by four trigonal pyramidal iodate anions, two tetrahedral selenate anions, and three coordinating water molecules. In the structure of 3, the Th(IV) cations are found as ThO 9 tricapped trigonal prisms. Each Th center is bound by six IO 3 1- anions and three CrO 4 2- anions forming a chiral three-dimensional structure. Second-harmonic generation of 532nm light from 1064nm radiation by a polycrystalline sample of 3 was observed. Crystallographic data (193K, MoKα, λ=0.71073): 1; monoclinic, P2 1 /c; a=7.0351(5)A, b=9.5259(7)A, c=9.0266(7)A, β=103.128(1), Z=4, R(F)=2.47% for 91 parameters with 1462 reflections with I>2σ(I); 2, monoclinic, P2 1 /n, a=7.4889(9)A, b=8.002(1)A, c=20.165(3)A, β=100.142(2), Z=4, R(F)=4.71% for 158 parameters with 2934 reflections with I>2σ(I); 3, orthorhombic, P2 1 2 1 2 1 , a=7.3672(5)A, b=9.3617(6)A, c=11.9201(7)A, Z=4, R(F)=2.04% for 129 parameters with 2035 reflections with I>2σ(I)

8th Asian Conference on Intelligent Information and Database Systems

CERN Document Server

Madeyski, Lech; Nguyen, Ngoc

2016-01-01

The objective of this book is to contribute to the development of the intelligent information and database systems with the essentials of current knowledge, experience and know-how. The book contains a selection of 40 chapters based on original research presented as posters during the 8th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2016) held on 14–16 March 2016 in Da Nang, Vietnam. The papers to some extent reflect the achievements of scientific teams from 17 countries in five continents. The volume is divided into six parts: (a) Computational Intelligence in Data Mining and Machine Learning, (b) Ontologies, Social Networks and Recommendation Systems, (c) Web Services, Cloud Computing, Security and Intelligent Internet Systems, (d) Knowledge Management and Language Processing, (e) Image, Video, Motion Analysis and Recognition, and (f) Advanced Computing Applications and Technologies. The book is an excellent resource for researchers, those working in artificial intelligence, mu...

Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response

Directory of Open Access Journals (Sweden)

Keyan Chen

2018-04-01

Full Text Available Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR on postoperative cognitive dysfunction (POCD and intestinal injury induced by cardiopulmonary bypass (CPB and its relationship with the Th17 response in order to provide a theoretical basis for organ protection and targeted drug therapy during the perioperative period. Methods: Sprague-Dawley rat models of CPB were established. Rat intestinal and brain injuries were observed after CPB using hematoxylin and eosin staining. Cell apoptosis was determined using terminal deoxynucleotidyl transferase dUTP nick end labeling. Inflammatory factors and markers of brain injury in rat serum were measured using enzyme-linked immunosorbent assay. The expression levels of Bcl-2, Bax, caspase-3, ZO-1, occludin, AQP4, RORγT, and α7nAchR were examined using western blotting. Transcription factor RORγT expression was determined using real-time fluorescent quantitative polymerase chain reaction. Th17 cells in the peripheral blood and spleen were determined using flow cytometry. α7nAchR knockout rats were established. The Th17 response in the peripheral blood and spleen of α7nAchR knockout rats was further verified using flow cytometry. Results: CPB can induce POCD and intestinal injury in rats. α7nAchR activation markedly reduced intestinal injury, POCD, neuronal apoptosis, proinflammatory factor expression, and number of CD4+IL-17+ cells. α7nAchR knockout significantly increased serum D-lactic acid, FABP2, S-100β, NSE, TNF-α, IL-6, and IL-17 secretion. The number of CD4+IL-17+ cells was also significantly increased. Conclusion: α7nAchR activation markedly ameliorates the intestinal injury and POCD induced by CPB. Inhibition of the Th17 immune response can reduce the proinflammatory response, which could provide a new method for clinical perioperative organ protection and targeted drug therapy.

Structural phase stability of ThSb and ThAs under pressure

International Nuclear Information System (INIS)

Venkatasubramaniam, K.; Rajagopalan, M.; Palanivel, B.; Kalpana, G.

1997-01-01

The high-pressure behaviour of thorium monopnictides is of considerable interest as these systems exhibit structural phase transitions under pressure. At ambient conditions these compounds crystallize in the NaCl-type(B1) structure. Experiments show that with the application of pressure these compounds transform to the CsCl-type (B2) structure. ThSb and ThAs are found to exhibit B1-B2 transition in the pressure range between 9-12 GPa and 1826 GPa respectively. In this work, we present the electronic and high-pressure behaviour of ThAs and ThSb performed using the tight-binding linear muffin-tin orbital method. The total energies within the atomic sphere approximation were calculated as a function of volume for both the B1 and B2 structures. The total energy calculations reveal that both ThSb and ThAs are stable in the B1 structure at ambient conditions and undergo structural transition to the B2 structure at pressures 78 and 240 kbar respectively, which are in good agreement with the experimental values. The calculated values of equilibrium lattice parameter and the transition pressure are found to be in good agreement with the experimental results. (author)

PREFACE: 7th International Conference on Modern Practice in Stress and Vibration Analysis

Science.gov (United States)

Dulieu-Barton, J. M.

2009-07-01

The proceedings contain the papers presented at the 7th International Conference on Modern Practice in Stress and Vibration Analysis. The collection of papers represents the range of activities that are carried out to understand the functionality of engineering systems and structures through stress/strain based evaluation and dynamic response. The scope is broad and covers theoretical studies, modelling and experimental evaluations. Many of the papers cover integration techniques and approaches to better understanding of system performance and failure. All of the papers have been peer reviewed by at least two experts and represent the state of the art of research in this area. The conference is the seventh in the series, following on from previous conferences in Bath, Glasgow, Nottingham, Dublin, Sheffield and Liverpool. Although based in the British Isles the conference has a truly international flavour with offerings from 22 countries. The conference is organised by the Institute of Physics Applied Mechanics Group (formerly the Stress and Vibration Group). It incorporates activities associated with the British Society for Strain Measurement including the Measurements Lecture, the EMex Exhibition and the Young Stress Analyst Competition. The organising committee is grateful for the support of all of the authors, the scientific committee and keynote speakers who played a significant role in the review process, to John Edwards who was instrumental in managing the paper review and submission process, Dawn Stewart and Claire Garland of the Institute of Physics for organising the conference, social programme and registration and Biana Gale of the British Society for Strain Measurement for organising the Exhibition. The organising committee is also grateful to the sponsors of the conference for their kind support and to the co-sponsors for distributing information on the conference. Professor Janice M Dulieu-Barton Professor of Experimental Mechanics University of

Measuring Listening Comprehension Skills of 5th Grade School Students with the Help of Web Based System

Science.gov (United States)

Acat, M. Bahaddin; Demiral, Hilmi; Kaya, Mehmet Fatih

2016-01-01

The main purpose of this study is to measure listening comprehension skills of 5th grade school students with the help of web based system. This study was conducted on 5th grade students studying at the primary schools of Eskisehir. The scale used in the process of the study is "Web Based Listening Scale". In the process of the study,…

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

DEFF Research Database (Denmark)

Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza M. H.

2017-01-01

Background: Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously we have shown that only Th1...... mice where trafficking of Th1 cells into the CNS was affected. We compared microglia and astrocyte response in the brain and spinal cord of these mice. We further treated astrocytes with supernatants from highly pure Th1 and Th17 cultures and assessed the mRNA expression of neurotrophic factors......, cytokines and chemokines using real-time PCR. Data obtained was analysed using Kruskal- Wallis test. Results: We observed in α4-deficient mice weak microglial activation but comparable astrogliosis to that of wild-type mice in the regions of the brain populated with Th17 infiltrates suggesting that Th17...

The Use of Monograms on Byzantine Seals in the Early Middle-Ages (6th to 9th Centuries)

OpenAIRE

Werner Seibt

2016-01-01

The paper deals especially with monograms on Byzantine lead seals. The early form was the block monogram, a type used already in Classical times, which came into fashion in the Byzantine world in the 6th or already in the 5th century and remained important till the early 7th century. Such monograms hide normally a name, a title or an office, the Greek ones in genitive, the Latin ones in nominative or genitive. Many of them can be read in different ways. For the double using of parts of letter...

Idaho National Laboratory Quarterly Performance Analysis for the 2nd Quarter FY 2015

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-04-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of events for the 2nd Qtr FY-15.

Russian Monastery’s Accounting and Auditing in the 16th –17th Centuries

OpenAIRE

Ivanov, Vladimir

2016-01-01

This paper reviews a history of accounting and auditing practice in 16th-17th centuries at the most known monastery of Russia – Solovetsky. This monastery was established in the first half of 15th c. For the first time the earliest of the preserved accounting documents of the monastery - saint hegumen Philip’s “memory” of donations and expense to the cloister building (1547/48) is introduced. The evolution of accounting system and basic principles of the income-expenditure books’ composition ...

The validation of science virtual test to assess 7th grade students’ critical thinking on matter and heat topic (SVT-MH)

Science.gov (United States)

Sya’bandari, Y.; Firman, H.; Rusyati, L.

2018-05-01

The method used in this research was descriptive research for profiling the validation of SVT-MH to measure students’ critical thinking on matter and heat topic in junior high school. The subject is junior high school students of 7th grade (13 years old) while science teacher and expert as the validators. The instruments that used as a tool to obtain the data are rubric expert judgment (content, media, education) and rubric of readability test. There are four steps to validate SVT-MH in 7th grade Junior High School. These steps are analysis of core competence and basic competence based on Curriculum 2013, expert judgment (content, media, education), readability test and trial test (limited and larger trial test). The instrument validation resulted 30 items that represent 8 elements and 21 sub-elements to measure students’ critical thinking based on Inch in matter and heat topic. The alpha Cronbach (α) is 0.642 which means that the instrument is sufficient to measure students’ critical thinking matter and heat topic.

Th1 and Th2 immune responses related to pelvic endometriosis Resposta imunológica Th1 e Th2 relacionada à endometriose pélvica

Directory of Open Access Journals (Sweden)

Sergio Podgaec

2010-01-01

Full Text Available OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A and 33 without the disease (Group B. Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, pOBJETIVO: Este estudo analisa a relação entre as características clínicas da endometriose e os padrões da resposta imune Th1/Th2. MÉTODOS: Estudo prospectivo realizado com 65 pacientes com endometriose (Grupo A e 33 pacientes sem a doença (Grupo B. Foram realizadas avaliação no fluido peritoneal e sangue periférico de IL 2, 4 e 10, TNF-alfa e IFN-gama. A significância foi estabelecida em p < 0,05. RESULTADOS: TNF-alfa encontrava-se elevado em pacientes com endometriose que apresentavam dispareunia de profundidade comparado com controle (média 4,5 pg/ml e 2,3 pg/ml, p< 0,05. Dentre essas pacientes (n=32, 65,5% apresentavam endometriose profunda. Pacientes com endometriose e infertilidade apresentavam concentrações maiores de IL-2 no fluido peritoneal quando comparadas com controle (média 5,9 pg/ml e 0,2 pg/ml, p< 0,05, sendo que neste grupo, 63,5% (n=14 apresentavam endometriose profunda. Foi observada também maior concentração de IL-10 nas pacientes que apresentavam endometriose ovariana quando comparadas às sem esse tipo de endometriose, assim como quando comparadas às pacientes do grupo controle (média 50pg/ml, 18,7pg/ml e 25,7pg/ml, p<0,05. CONCLUSÃO: Estes resultados sugerem que quando dados clínicos específicos associam-se a uma produção elevada de certas citocinas, ocorre um padrão de resposta Th1 que pode estar associado à endometriose profunda.

IAEA International Database on Irradiated Nuclear Graphite Properties. 7th meeting of the Technical Steering Committee

International Nuclear Information System (INIS)

Humbert, D.; Wickham, A.J.

2005-06-01

This report summarizes the Consultant Meeting '7th Meeting of the Technical Steering Committee for the International Database on Irradiated Nuclear Graphite Properties' held on 16-17 March 2005 at the IAEA Headquarters, Vienna, Austria. The purposes of the meeting were to review the matters and actions identified in the previous meeting, undertake a review of the current status of the database and to make recommendations for actions for the next year. The purposes of the meeting were fully met. This report contains the current status of the identified actions as well as a summary of the recommendations on enhancements to the database. (author)

The solidification behaviour of the UO{sub 2}–ThO{sub 2} system in a laser heating study

Energy Technology Data Exchange (ETDEWEB)

Böhler, R. [European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany); Delft University of Technology, Faculty of Applied Sciences, Department of Radiation Science and Technology, Mekelweg 15, 2629 JB Delft (Netherlands); Quaini, A. [Politecnico di Milano, Department of Energy, Enrico Fermi Center for Nuclear Studies (CeSNEF), via La Masa 34, 20156 Milano (Italy); Capriotti, L. [Politecnico di Milano, Department of Energy, Enrico Fermi Center for Nuclear Studies (CeSNEF), via La Masa 34, 20156 Milano (Italy); European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany); Çakır, P. [Ege Univerity, Institute of Nuclear Sciences, 35100 Bornova Izmir (Turkey); European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany); Beneš, O.; Boboridis, K.; Guiot, A. [European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany); Luzzi, L. [Politecnico di Milano, Department of Energy, Enrico Fermi Center for Nuclear Studies (CeSNEF), via La Masa 34, 20156 Milano (Italy); Konings, R.J.M. [European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany); Manara, D., E-mail: dario.manara@ec.europa.eu [European Commission, Joint Research Centre, Institute for Transuranium Elements (ITU), P.O. Box 2340, 76125 Karlsruhe (Germany)

2014-12-15

Highlights: • Melting of the full UO{sub 2}–ThO{sub 2} system was studied by laser heating. • A minimum melting point was found around 5 mol% ThO{sub 2} and T = 3098 K. • Ideal solution behaviour near melting was observed for compositions richer in ThO{sub 2}. • These compounds were also studied by Raman spectroscopy before and after melting. - Abstract: The high-temperature phase diagram of the UO{sub 2}–ThO{sub 2} system has been experimentally revisited in the present study for the first time since 1970, using a laser heating approach combined with fast pyrometry in a thermal arrest method. The melting/solidification temperature, which is of fundamental information for a reactor design was studied here. It was found that low addition of ThO{sub 2} to UO{sub 2} would result in a slight decrease of the solidification temperature. A minimum was found at 3098 K around a composition of 5 mol% ThO{sub 2}. The solid/liquid transition temperature was then observed to increase again with increasing ThO{sub 2} fraction. The literature value of pure ThO{sub 2} (around 3630 K) was well reproduced here. Important experimental difficulties, stemming from the high temperatures reached during the measurements, as well as a complete investigation with electron microscopy, Raman spectroscopy and powder X-ray diffraction, are extensively discussed. These results show the importance of the high-temperature oxygen chemistry in this actinide oxide compound.

Mountain-Scale Coupled Processes (TH/THC/THM)

International Nuclear Information System (INIS)

Dixon, P.

2004-01-01

The purpose of this Model Report is to document the development of the Mountain-Scale Thermal-Hydrological (TH), Thermal-Hydrological-Chemical (THC), and Thermal-Hydrological-Mechanical (THM) Models and evaluate the effects of coupled TH/THC/THM processes on mountain-scale UZ flow at Yucca Mountain, Nevada. This Model Report was planned in ''Technical Work Plan (TWP) for: Performance Assessment Unsaturated Zone'' (BSC 2002 [160819], Section 1.12.7), and was developed in accordance with AP-SIII.10Q, Models. In this Model Report, any reference to ''repository'' means the nuclear waste repository at Yucca Mountain, and any reference to ''drifts'' means the emplacement drifts at the repository horizon. This Model Report provides the necessary framework to test conceptual hypotheses for analyzing mountain-scale hydrological/chemical/mechanical changes and predict flow behavior in response to heat release by radioactive decay from the nuclear waste repository at the Yucca Mountain site. The mountain-scale coupled TH/THC/THM processes models numerically simulate the impact of nuclear waste heat release on the natural hydrogeological system, including a representation of heat-driven processes occurring in the far field. The TH simulations provide predictions for thermally affected liquid saturation, gas- and liquid-phase fluxes, and water and rock temperature (together called the flow fields). The main focus of the TH Model is to predict the changes in water flux driven by evaporation/condensation processes, and drainage between drifts. The TH Model captures mountain-scale three dimensional (3-D) flow effects, including lateral diversion at the PTn/TSw interface and mountain-scale flow patterns. The Mountain-Scale THC Model evaluates TH effects on water and gas chemistry, mineral dissolution/precipitation, and the resulting impact to UZ hydrological properties, flow and transport. The THM Model addresses changes in permeability due to mechanical and thermal disturbances in

The Equine Distal Limb. An Atlas of Clinical Anatomy and Comparative Imaging (7th impression, J-M. Denoix : book review

Directory of Open Access Journals (Sweden)

R. Gottschalk

2011-05-01

Full Text Available Originally published in 2000, this 7th impression is testimony to the ongoing relevance of a classical reference 11 years after its original publication. The book is authored by Jean-Marie Denoix who is well known in South Africa, having been the main speaker at an annual SAEVA congress. He is internationally recognised as a leading equine anatomist and diagnostic imager.

The 7th questionnaire report of safety control in nuclear medicine

International Nuclear Information System (INIS)

2005-01-01

The questionnaire has been done every three years from 1986 for the ultimate purpose of safe medical examinations and this 7th one was performed for the objective period of April 1, 2001-March 31, 2004. Subjects were 1,275 nuclear medicine facilities and answers were obtained in 77.2%. Questionnaire concerned the personnel involved in nuclear medical examinations (qualifications/medical doctor, pharmacist and radiology technologist and others), instruments (an additional investigation in the present period was conducted on PET/CT with cyclotron and automatic synthesis equipment and on SPECT/CT), accidents experienced, matters possibly leading to accident, improvement in safety control, serious trouble and breakage of the instrument, requests for the instrument manufacturers and so on. Results were: qualified radiology technologists amounted to 70% and doctors, 20%; personnel number for tests in vitro tended decreased; SPECT-camera with 2 detectors increased and with 1, obviously decreased; PET and related equipments greatly increased; check rate for imaging instruments was about 80%; gamma cameras were used over their maximum time limits recommended by manufacturers; actual accidents at examination increased but were not serious; improvements of instruments for safety sensor and of operation to avoid errors were required; mind for preventing accident was improved; many requests for the manufacturers were proposed. (author)

New trends in few-body systems a 30th anniversary collection

CERN Document Server

2017-01-01

Few-Body Systems refer to a multidisciplinary subject of research in different sectors of physics in which the number of degrees of freedom governing the dynamics is sufficiently low to allow a description with controlled approximations. Examples can be found in atomic, nuclear and subnuclear physics as well as in some aspects of condensed matter. This issue, celebrating the 30th Anniversary of the Journal, contains two review articles, one in exotic hadrons and one in antikaon-nucleon systems, as well as a selection of original articles on experimental and theoretical physics in which modern problems in few-body systems are discussed. Specific arguments, presented by world expert leaders, are very extensive and include the three and four-nucleon system, short-range correlations, universal behavior in few-boson systems, perspectives on the origin of hadron masses, scattering problems and studies using electromagnetic probes. This issue gives an overview of actual problems in Few-Body Systems.

Innovative microstructures in ThO2-UO2 system

International Nuclear Information System (INIS)

Kutty, T.R.G.; Sengupta, A.K.; Majumdar, S.; Sah, D.N.; Kamath, H.S.

2005-01-01

The basic properties that really matter to the nuclear scientists are those that have greatest influence on microstructure: crystal structure, defects concentration and phase stability. The role of microstructure and crystal defects in determining the engineering properties are always acknowledged. Microstructure of nuclear fuels controls the in-pile fuel behavior like fission gas release, plasticity, in-pile creep and swelling. Conventional nuclear ceramic fabrication process consists of a number of stages, including calcination, milling, incorporating additives, pressing, drying and densification. Since each of these steps affects the microstructure of fuel pellets they must all be understood and a more holistic approach is required when processing nuclear ceramics compared to metals and polymers. It is possible to obtain a wide range of microstructures for ThO 2 -UO 2 system if a proper fabrication route is chosen. It is possible to tailor microstructure as per our requirement so that an improved behaviour during irradiation is expected. The improvement in plasticity and fission gas release can be attained by modifying the microstructure during fabrication. This paper deals with fabrication of ThO 2 -UO 2 pellets of varying U content and its characterization with the help of optical microscopy, XRD, SEM and EPMA. The microstructures are characterized in terms grain size, pore size and its distribution and homogeneity of uranium. (author)

High-pressure studies of a ThMn sub 1 sub 2 -type actinide compound: UFe sub 5 Al sub 7

CERN Document Server

Halevy, I; Kimmel, G; Atzmony, U; Pereira, L C J; Goncalves, A P; Schäfer, W

2002-01-01

The ternary inter-metallic compound, UFe sub 5 Al sub 7 , crystallize in a tetragonal ThMn sub 1 sub 2 type structure. In the as-cast samples a residual phase of FeAl (approx 2% wt) was identified in the grain boundaries. The amount of the residual cubic phase of FeAl was determined by Rietveld analysis and reduced by the annealing process. UFe sub 5 Al sub 7 maintains the tetragonal symmetry as a function of pressure, while FeAl keeps the cubic structure as was determined by the Rietveld analysis. The volume-pressure curve calculated from the x-ray analysis is V/V sub 0 = 0.87 for UFe sub 5 Al sub 7 at 26.0 GPa.

7th Patras workshop on axions, WIMPs and WISPs (PATRAS 2011). Proceedings

Energy Technology Data Exchange (ETDEWEB)

Zioutas, Konstantin; Schumann, Marc (eds.)

2011-12-15

The year 2011 was an exciting period to work on the ''dark side'' of the Universe. Several experimental claims of the direct detection of WIMP dark matter were challenged by the restrictive limits of several others. Dedicated experiments searching for axions, another well motivated dark matter candidate, and for axion-like particles continued to improve their limits and got an additional boost by puzzling astrophysical observations and new developments in theory. The LHC collected an unexpectedly large amount of data and started to produce results at an amazing speed. And finally, this year's Nobel price of physics was awarded to the observation of the accelerating expansion of the Universe, an effect which might be related to dark energy, whose nature remain among the biggest mysteries in physics. These exciting topics and many more important aspects of particle- and astroparticle physics were discussed between experimentalists and theorists at the 7th Patras Workshop on Axions, WIMPs, and WISPs. The workshop took place from June 27 - July 1, 2011, in the Royal Myconian and Myconian Imperial Resorts Hotels on the Greek island of Mykonos. As in the previous years, it was a very fruitful and lively meeting in an inspiring and open atmosphere, which allowed for many open and constructive discussions also on controversial topics. The scientific exchange, the beautiful scenery of the island, the venue itself, the food, an excursion to the ancient ruins of Delos, and finally an amazing conference dinner made this meeting really unique. The ''spirit'' of the workshop and its atmosphere cannot be brought to paper, but many of its scientific highlights are collected in these proceedings. We are looking forward to the 8th Patras Workshop, which will be held in Chicago (USA) July 18-22, 2012. It will be organized jointly by our US colleagues Andrei Afanasev (JLAB), Oliver Baker (Yale), and William Wester (FNAL).

11th AINSE Plasma Physics Conference 1977, 7th and 8th February, 1977, Lucas Heights, NSW (Australia), 9th February, 1977, University of Sydney. Abstracts of Papers 1-54

Energy Technology Data Exchange (ETDEWEB)

Walsh, C. J. [ed.

1977-02-15

Abstracts of papers 1-54 scheduled for oral presentation at the 11th AINSE Plasma Physics Conference are included. No introductory or summary information is provided. Each page consists of the title, authors, organization affiliation, and abstract.

12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems

Energy Technology Data Exchange (ETDEWEB)

Berk, Herbert L.; Breizman, Boris N.

2014-02-21

The 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems took place in Austin, Texas (7–11 September 2011). This meeting was organized jointly with the 5th IAEA Technical Meeting on Theory of Plasma Instabilities (5–7 September 2011). The two meetings shared one day (7 September 2011) with presentations relevant to both groups. Some of the work reported at these meetings was then published in a special issue of Nuclear Fusion [Nucl. Fusion 52 (2012)]. Summaries of the Energetic Particle Conference presentations were given by Kazuo Toi and Boris Breizman. They respectively discussed the experimental and theoretical progress presented at the meeting. Highlights of this meeting include the tremendous progress that has been achieved in the development of diagnostics that enables the ‘viewing’ of internal fluctuations and allows comparison with theoretical predictions, as demonstrated, for example, in the talks of P. Lauber and M. Osakabe. The need and development of hardened diagnostics in the severe radiation environment, such as those that will exist in ITER, was discussed in the talks of V. Kiptily and V.A. Kazakhov. In theoretical studies, much of the effort is focused on nonlinear phenomena. For example, detailed comparison of theory and experiment on D-III-D on the n = 0 geodesic mode was reported in separate papers by R. Nazikian and G. Fu. A large number of theoretical papers were presented on wave chirping including a paper by B.N. Breizman, which notes that wave chirping from a single frequency may emanate continuously once marginal stability conditions have been established. Another area of wide interest was the detailed study of alpha orbits in a burning plasma, where losses can come from symmetry breaking due to finite coil number or magnetic field imperfections introduced by diagnostic or test modules. An important area of development, covered by M.A. Hole and D.A. Spong, is concerned with the self

Studying the Ability of 7th Grade Students to Define the Circle and Its Elements in the Context of Mathematical Language

Science.gov (United States)

Akarsu, Esra; Yilmaz, Süha

2015-01-01

In this study, it was aimed to study the mathematical language skills that the 7th grade students use in defining the circle and its elements. In the study, the mathematical language skills of students that they use in defining the circle and its elements in a scenario were compared to the mathematical language skills they use in defining them…

Reciprocal modulation of helper Th1 and Th17 cells by the β2-adrenergic receptor agonist drug terbutaline.

Science.gov (United States)

Carvajal Gonczi, Catalina M; Tabatabaei Shafiei, Mahdieh; East, Ashley; Martire, Erika; Maurice-Ventouris, Meagane H I; Darlington, Peter J

2017-09-01

Catecholamine hormones are powerful regulators of the immune system produced by the sympathetic nervous system (SNS). They regulate the adaptive immune system by altering T-cell differentiation into T helper (Th) 1 and Th2 cell subsets, but the effect on Th17 cells is not known. Th17 cells, defined, in part, by chemokine receptor CCR6 and cytokine interleukin (IL)-17A, are crucial for mediating certain pathogen-specific responses and are linked with several autoimmune diseases. We demonstrated that a proportion of human Th17 cells express beta 2-adrenergic receptor (β2AR), a G protein-coupled receptor that responds to catecholamines. Activation of peripheral blood mononuclear cells, which were obtained from venous blood drawn from healthy volunteers, with anti-cluster of differentiation 3 (CD3) and anti-CD28 and with a β2-agonist drug, terbutaline (TERB), augmented IL-17A levels (P < 0.01) in the majority of samples. TERB reduced interferon gamma (IFNγ) indicating that IL-17A and IFNγ are reciprocally regulated. Similar reciprocal regulation was observed with dbcAMP. Proliferation of Th cells was monitored by carboxyfluorescein diacetate N-succinimidyl ester labeling and flow cytometry with antibody staining for CD3 and CD4. TERB increased proliferation by a small but significant margin (P < 0.001). Next, Th17 cells (CD4 + CXCR3 - CCR6 + ) were purified using an immunomagnetic positive selection kit, which removes all other mononuclear cells. TERB increased IL-17A from purified Th17 cells, which argues that TERB acts directly on Th17 cells. Thus, hormone signals from the SNS maintain a balance of Th cells subtypes through the β2AR. © 2017 Federation of European Biochemical Societies.

Professional Responsibility and the Welfare System in Spain at the Turn of the 19th Century

Directory of Open Access Journals (Sweden)

León Sanz, Pilar

2006-11-01

Full Text Available This essay analyzes the attitudes of physicians prior to the establishment of a social welfare system in Spain, based on professional sources from 1890-1910. Firstly we revised the Systems of Collectivised Assistance during the Transition from the 19th to the 20th Century; then, the article discusses the corporativist reaction of Physicians to the different Welfare Systems. We observe that the criticism of insurance companies was unanimous. Nonetheless, there was a diversity of opinions regarding mutual societies and the associations of mutual assistance. The professional arguments used against the associations, mutuals and insurance companies were formulated around, in addition to the professional instability of the times, the changes in civil and criminal responsibility of the physician as a result of new legal regulations. We found physicians in favour of establishing a welfare system that was not exclusively public and which, in addition to benefiting the needy, would benefit the interests of the profession as well.

New Archeointensity Data from Late Neolithic Yarim Tepe 1 and 2 Settlements (Northern Iraq) Dated From The Pre-Halaf and Halaf Periods (7TH-6TH Millennia BC)

Science.gov (United States)

Akimova, S.; Gallet, Y.; Amirov, S.; Petrova, N.

2016-12-01

The main objective of this study is to recover the geomagnetic field intensity variations in the Middle East during the 7th and 6th millennia BC, with a particular focus on rapid fluctuations. We will report on new archeointensity data obtained from two ancient Late Neolithic settlements called Yarim Tepe I and II, located today in Northern Iraq, which were excavated by Soviet archeologists in the seventies. Yarim Tepe II, comprising a 7-m thick sequence of cultural deposits divided into nine successive levels, is dated from the Halaf period ( 5950-5300 BC). Yarim Tepe I is dated from the Pre-Halaf period ( 6300-5950 BC), with three recognized cultural phases referred to as Hassuna I, II and III. There, the deposits form a sequence of 6.5 m, which were divided into 12 archeological levels. Most of the archeological artifacts discovered during the excavations, in particular thousands of potsherds, are stored at the repository of Archeological Institute in Moscow, where our sampling was undertaken. We collected 29 groups of potsherds from Yarim Tepe II and 22 groups from Yarim Tepe I from superimposed stratigraphic layers having on average a thickness of about 20 cm. Each group consists of at least 3 (up to 10) fragments. All analyses were carried out using the three-axis vibrating sample magnetometer Triaxe, which allows magnetization measurements of a small sample (developed for the Triaxe magnetometer takes into account both the anisotropy and cooling rate effects on thermoremanent magnetization acquisition. Together with other data previously obtained from Syria and Bulgaria, the new archeointensity results show the occurrence of rapid geomagnetic field fluctuations in the Middle East during the Late Neolithic period, in particular during the 6th millennium BC. The data from Yarim Tepe II indeed confirm the occurrence of a short-lasting intensity peak around 5500 BC, with intensity variation rates as high as 0.35 - 0.15 µT/year over a few decades. We will also

Pressure-concentration (P-X) diagram for the Ce-Th alloy system

International Nuclear Information System (INIS)

Gu, G.; Vohra, Y.K.; Winand, J.M.; Spirlet, J.C.

1995-01-01

Pressure is an important variable in the phase stability of rare earth and actinide metals and alloys. This is largely due to the enormous change of the f-electron character induced by high pressure. Under high pressure, the increased f-electron overlap and interactions between the f-electrons and the spd conduction electrons are the main causes of the change of f-electron behavior and the relevant phase transformations. Diamond anvil cell techniques now allow for pressures over 300 GPa and this has given new impetus to the field of structural phase transformations. In this paper, the authors report their high pressure measurements on a series of Ce 1-x Th x alloys performed at ambient temperature in a diamond anvil cell using synchrotron x-ray source. In particular, the authors focus their attention on the γ(fcc) to α(fcc) and α to bct (body centered tetragonal) phase transformations caused by application of high pressure. The data is combined with the earlier measurements to construct a P-X diagram for the Ce-Th Alloy system

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

Science.gov (United States)

Duechting, Andrea; Przybyla, Anna; Kuerten, Stefanie; Lehmann, Paul V

2017-09-12

During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively. Traditionally, these cytokines are measured within 6 h in flow cytometry. We show here that 6 h of stimulation is sufficient to detect peptide-induced production of IFN-γ, but 24 h are required to reveal the full frequency of protein antigen-specific Th1 cells. Also the detection of IL-2 producing Th1 cells requires 24 h stimulation cultures. Measurements of IL-4 producing Th2 cells requires 48-h cultures and 96 h are required for frequency measurements of IL-5 and IL-17 secreting T cells. Therefore, accounting for the differential secretion kinetics of these cytokines is critical for the accurate determination of the frequencies and ratios of antigen-specific Th1, Th2, and Th17 cells.

Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.

Science.gov (United States)

Chen, Xuemei; Wang, Junfu; Wang, Rui; Su, Qinghong; Luan, Junwen; Huang, Haiyan; Zhou, Peng; Liu, Jinsheng; Xu, Xiaoqun

2016-02-01

Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.

Design of a 3.7 GHz oscillator for the solid state drive of the LHCD system

International Nuclear Information System (INIS)

Sainkar, Sandeep; Dixit, Harish; Cheeran, Alice; Sharma, P.K.

2017-01-01

The LHCD system is commissioned on the SST-1 tokamak for the current drive. It has a capability to generate power of 2 MW CW at 3.7 GHz and deliver the power to the tokamak via a grill antenna through a phased array of wave guides. The system relies on 4 Klystrons (TH-2103D) each generating 500 kW CW power. The klystrons act as an amplifier providing a gain of 40 dB with a bandwidth of 10 MHz and amplify the input power provided by a solid state driver. The klystron requires a supply of 65 kV and 20A for its operation and has to be extensively conditioned before it can be operated even for obtaining lower power levels. This paper describes the design of oscillator for this system. The oscillator is based on bipolar junction transistor BFR360F. Linear and non-linear analysis has been performed on the design to ascertain its performance. The oscillator delivered a power of 20 mW at 3.7 GHz

7th International Seminar on Tropical Swine Production 2017 on the Occasion of the 45th Anniversary of Cuba's Swine Research Institute

Directory of Open Access Journals (Sweden)

Royal Academy for Overseas Sciences

2016-01-01

Full Text Available 7th International Seminar on Tropical Swine Production 2017 on the Occasion of the 45th Anniversary of Cuba's Swine Research Institute. Cet article analyse les facteurs qui influencent l'adoption du Mucuna pruriens en zone cotonnière ouest du Burkina Faso. Les données ont été collectées dans 3 villages par la méthode active de recherche participative et par enquête auprès de 50 exploitations impliquées dans le développement de techniques de production du mucuna adaptées aux systèmes de production locaux. La co-construction de ces techniques s'est faite de 2005 à 2015 selon une démarche de recherche-action en partenariat. Les résultats de la régression logistique révèlent que les variables qui influent positivement la décision d'adopter sont le nombre d'actifs et de fosses fumières, le sexe, l'accès au marché, l'expérimentation du M. pruriens, la pratique de l'embouche (P&amp;amp;amp;amp;amp;amp;amp;amp;lt;0,1 et le nombre de participation aux réunions de la plateforme d'innovation par l'exploitant (P&amp;amp;amp;amp;amp;amp;amp;amp;lt;0,05. Par contre la quantité d'urée appliquée par hectare et le revenu de l'exploitation affectent négativement l'adoption (P&amp;amp;amp;amp;amp;amp;amp;amp;lt;0,1. La réussite des actions de développement de la culture des légumineuses fourragères passe par la prise en compte raisonnée de ces facteurs.

Quality Assurance Tracking System - R7 (QATS-R7)

Data.gov (United States)

U.S. Environmental Protection Agency — This is metadata documentation for the Quality Assurance Tracking System - R7, an EPA Region 7 resource that tracks information on quality assurance reviews. Also...

The semantic web : research and applications : 7th extended semantic web conference, ESWC 2010, Heraklion, Crete, Greece, May 30 - June 3, 2010 : proceedings

NARCIS (Netherlands)

Aroyo, L.M.; Antoniou, G.; Hyvönen, E.; Teije, ten A.; Stuckenschmidt, H.; Cabral, L.; Tudorache, T.

2010-01-01

Preface. This volume contains papers from the technical program of the 7th Extended Semantic Web Conference (ESWC 2010), held from May 30 to June 3, 2010, in Heraklion, Greece. ESWC 2010 presented the latest results in research and applications of Semantic Web technologies. ESWC 2010 built on the

Electrochemical reactions of the Th4+/Th couple on the tungsten, aluminum and bismuth electrodes in chloride molten salt

International Nuclear Information System (INIS)

Liu, Kui; Yuan, Li-Yong; Liu, Ya-Lan; Zhao, Xiu-Liang; He, Hui; Ye, Guo-An; Chai, Zhi-Fang; Shi, Wei-Qun

2014-01-01

This work concerns the electrochemical behaviors of Th 4+ on the tungsten, aluminum and bismuth electrodes in the LiCl-KCl eutectic, respectively, at 773 K. Cyclic voltammetry and square wave voltammetry were employed to investigate the cathodic reduction of Th 4+ . The results demonstrate that the reduction of Th 4+ is a one step process with a transfer of 4 electrons. The reversibility of the Th 4+ /Th couple on the bismuth film and tungsten electrodes is directly confirmed by the CV. The diffusion coefficient is also calculated to be (2.23 ± 0.16) × 10 −5 and (7.19 ± 0.12) × 10 −5 cm 2 /s by applying both cyclic voltammetry and chronopotentiometry, respectively. A series of redox couples were confirmed to be associated with the formation of different kinds of Al-Th intermetallic compounds. Compared to Al electrode, a cathodic shift of the reduction potential of the Th 4+ is observed on the Al film electrode which is not conducive for the potentiostatic extraction of thorium. The cathodic depolarization gives a shift of 420 mV on the Al electrode, while 490 mV on the Bi film electrode for the reduction of Th 4+ compared to the inert W electrode. The reduction potential of Th 4+ on the Bi film electrode is 70 mV more anodic than that on the Al electrode. Potentiostatic electrolyses were carried out on an Al plate and Bi liquid electrode to confirm the formation of the Th alloys. Two Al-Th alloys (Al 3 Th and Al 2 Th) and one Bi-Th alloy (Bi 2 Th) were obtained, respectively

SenThIS - Sentinels of Thuringian information systems

Science.gov (United States)

Naue, Sandra; Krause, Peter

2016-04-01

Decision-making for sustainable environmental resource management or risk prevention is facing the problem of constantly changing conditions related to the projected changes of climate, demography and socio-economy. Herefore, adaptable tools and methods which can reflect such changes are needed for an efficient management. The need to improve existing tools is a challenge the departments of German environmental authorities at state and federal level are facing at this time. Additionally the increasing demands for work process optimization due to financial cutbacks are coming into play. Consequently the need for suitable adaptation measurements for short and long term changes of environmental state variables is growing. The importance of spatio-temporal data, providing continuous observation about the state of the environmental system and its changes, is therefore increasing in order to elaborate adaptation strategies. In this case earth observation is a useful source for the required data. With the new Sentinel fleet, ESA's Copernicus Program is providing a possibility to obtain such information free in high temporal and spatial resolution. The BMVI funded project SenThIS, a collaborative project by the Thuringian State Institute for Environment and Geology (TLUG), the Thuringian Forest Department and two SMEs EOS GmbH and Feiffer consult is aiming at utilizing Copernicus data and services for operational tasks on a federal level. It addresses this aforementioned deficit through the development and implementation of a processing chain for synergetic and automated application of remote sensing data and products to accomplish operational state tasks. The product development is characterized by the synergetic application of remote sensing data and suitable models. Design and calibration of the models base on Sentinel 1/2 data and additional information (e.g. meteorological data, in-situ measurements). This results in products of highly temporal and spatial resolution

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

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Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza; Knier, Benjamin; Toft-Hansen, Henrik; Gudi, Viktoria; Floess, Stefan; Huehn, Jochen; Owens, Trevor; Korn, Thomas; Stangel, Martin

2017-10-16

Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS. To understand the effects driven by Th17 cells in the CNS, we induced experimental autoimmune encephalomyelitis in wild-type mice and CD4 + T cell-specific integrin α4-deficient mice where trafficking of Th1 cells into the CNS was affected. We compared microglial and astrocyte response in the brain and spinal cord of these mice. We further treated astrocytes with supernatants from highly pure Th1 and Th17 cultures and assessed the messenger RNA expression of neurotrophic factors, cytokines and chemokines, using real-time PCR. Data obtained was analyzed using the Kruskal-Wallis test. We observed in α4-deficient mice weak microglial activation but comparable astrogliosis to that of wild-type mice in the regions of the brain populated with Th17 infiltrates, suggesting that Th17 cells target astrocytes and not microglia. In vitro, in response to supernatants from Th1 and Th17 cultures, astrocytes showed altered expression of neurotrophic factors, pro-inflammatory cytokines and chemokines. Furthermore, increased expression of chemokines in Th1- and Th17-treated astrocytes enhanced recruitment of microglia and transendothelial migration of Th17 cells in vitro. Our results demonstrate the delicate interaction between T cell subsets and glial cells and how they communicate to mediate their effects. Effectors of Th1 act on both microglia and astrocytes whereas Th17 effectors preferentially target astrocytes to promote neuroinflammation.

FOREWORD: 9th International Conference on Compressors and their Systems

Science.gov (United States)

Kovacevic, Ahmed, Prof

2015-08-01

The 9th International Conference on Compressors and their Systems will be held in London from 5th - 9th September 2015, and as its Chairman, it is my pleasure to welcome you. This series of conferences started in 1999 organised by the Fluid Machinery Group of the Institution of Mechanical Engineers (IMechE) but since 2009 it has been managed by City University London in conjunction with the IMechE and the Institute of Refrigeration, both of which have been very proactive in promoting it. The Organising committee is grateful for their support and continued encouragement. This year, after rigorous reviewing, we have accepted over 80 technical papers for publication, the highest number in the conference history. On behalf of the organising committee I would like to thank the reviewers for their hard work and assistance. In addition to the main technical sessions, this year we have introduced a third day, specifically for Industry, to consider technology, business and market drivers on compressor developments. The traditional series of the short courses is this year continuing prior to the main event with the second short course/forum on Computational Fluid Dynamics in rotating positive displacement machines. I would like to extend my special thanks to our main sponsors, Holroyd PTG, Howden and Kapp Niels for their continuing support for the conference. With their generous contributions we have managed to keep the conference fees at the same level as in 2013, despite extending it to 3 days and holding it outside the University this year. The welcome reception on Sunday 6th September 2015 is dedicated to the celebration of the 20th anniversary of the Centre for Positive Displacement Compressors Technology which was formed at City University in 1995 with support from the Royal Academy of Engineering and Holroyd; its main aim being to assist British manufacturers of screw compressors. The Centre has since made a significant impact on the screw compressor world, far beyond

Nutrition Education in Secondary Education (7th to 11th grades Through the Crosscutting Topic “Education for Health” From an Useful-For-Life Approach

Directory of Open Access Journals (Sweden)

José Francisco Quirós-Rojas

2015-05-01

Full Text Available This paper provides the results of a research study conducted to determine how science teachers from four schools of the San José Regional Branch of the Costa Rican Ministry of Public Education undertake the nutrition topic at their schools; and, at the same time, find out about their interest in approaching nutrition as an useful-for-life issue, through the crosscutting topic “Education for Health.” In addition, this study intended to identify the perceptions of students about good nutrition in favor of healthy a lifestyle. Based on the nature of the work, the study followed a naturalistic paradigm towards a dominant qualitative approach, in a community-based type of study.  Questionnaires and interviews were used as research instruments; the sample included 6 science teachers and 60 students of ninth grade.   The information was analyzed and triangulated. The results indicated that teachers apply the useful-for-life approach in nutrition education, empirically; innovative activities are not widely used; and there is a need to strengthen knowledge regarding the use of crosscutting topics in the curriculum. In addition, this study reported that students are aware of—but do not implement—good daily life actions to change bad eating habits and favor preventive health.  This research project puts forward teaching strategies to be applied in secondary education (7th to 11th grades to approach nutrition from this perspective.

The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017.

Science.gov (United States)

Kinkorová, Judita

2018-02-01

The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarkers in oncology: new horizons and challenges in the diagnosis and treatment of cancer' [ 1 ]. The congress was co-organized by ISOBM, European Group on Tumor Markers (EGTM) and Brazilian Society of Clinical Pathology SBPC/ML. The event attracted more than 180 participants from all over the world. The program offered many topics regarding discovery, validation, evaluation and use of tumor biomarkers. The presentations were split into the key note lectures, oral presentations, poster presentations and satellite symposiums sponsored by companies. The congress offered participants the opportunity to link clinical and research oncologists to discuss new tools for diagnosis and monitoring of cancer diseases. Prominent people in the field of cancer research and clinical oncology were presented and offered the unique opportunity to exchange experiences and knowledge in an international forum [ 2 ]. Compared with previous ISOBM congresses, it was held in Latin America for the first time, and due to that more participants from Latin America were present.

Association between Th1/Th2 immune imbalance and obesity in women with or without polycystic ovary syndrome.

Science.gov (United States)

Gong, Ping; Shi, Bingwei; Wang, Juan; Cao, Peixia; Diao, Zhenyu; Wang, Yuji; Hu, Yali; Li, Shuping

2018-02-15

This study aimed to investigate the Th1/Th2 cells in peripheral blood of PCOS patients, and assess the potential correlation between Th1/Th2 imbalance and obesity. Thirty-nine PCOS patients and 23 age-matched controls were enrolled. The PBMCs were obtained before pharmacological intervention in women with or without PCOS. The profiles of Th1 (IFN-γ) and Th2 (IL-4) cytokines of CD3 + CD - T lymphocyte subsets were analyzed by flow cytometry. Plasma sex hormones including E 2 , T, FSH, LH, and FINS, FPG were measured, together with BMI, WC, LH/FSH, E 2 /T and HOMA-IR index being calculated. Association between Th1/Th2 imbalance and BMI, WC were evaluated. The proportion of Th1 cells and Th1/Th2 ratio were significantly higher in PCOS patients than those in controls, accompanied by elevated T, LH, LH/FSH, FINS, HOMA-IR index and reduced E 2 /T. The Th1/Th2 ratio was increased when BMI and WC were enhanced in PCOS. Moreover, the significant difference of Th1/Th2 ratio was observed between WC subgroups of PCOS. It is concluded that Th1 type immunity is predominant in systemic immunization of PCOS patients. Th1/Th2 immune imbalance is connected with obesity, especially abdominal obesity, and may be one of the underlying mechanism for the pathogenesis of PCOS.

Fasciola hepatica reinfection potentiates a mixed Th1/Th2/Th17/Treg response and correlates with the clinical phenotypes of anemia

Science.gov (United States)

Perez-Crespo, Ignacio; Chillón-Marinas, Carlos; Khoubbane, Messaoud; Quesada, Carla; Reguera-Gomez, Marta; Mas-Coma, Santiago; Fresno, Manuel; Gironès, Núria

2017-01-01

Background Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. Methodology/Principal findings The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats. In a cross-sectional study, the expression of the genes associated with Th1 (Ifng, Il12a, Il12b, Nos2), Th2 (Il4, Arg1), Treg (Foxp3, Il10, Tgfb, Ebi3), and Th17 (Il17) in the spleen and thymus was analyzed. After 20 weeks of primary infection, PI did not present significant changes in the expression of those genes when compared to non-infected rats (NI), but an increase of Il4, Arg1 and Ifng mRNA in the spleen was observed in R12, suggesting the existence of an active mixed Th1/Th2 systemic immune response in reinfection. Foxp3, Il10, Tgfb and Ebi3 levels increased in the spleen in R12 when compared to NI and PI, indicating that the Treg gene expression levels are potentiated in chronic phase reinfection. Il17 gene expression levels in R12 in the spleen increased when compared to NI, PI and R8. Gene expression levels of Il10 in the thymus increased when compared to NI and PI in R12. Ifng expression levels in the thymus increased in all reinfected rats, but not in PI. The clinical phenotype was determined by the fluke burden, the rat body weight and the hemogram. Multivariate mathematical models were built to describe the Th1/Th2/Th17/Treg expression levels and the clinical phenotype. In reinfection, two phenotypic patterns were detected: i) one which includes only increased splenic Ifng

Power System Challenge: Synthesis Report for the 7th Clean Energy Ministerial

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-06-01

The Clean Energy Ministerial's (CEM's) Power System Challenge was established in 2015 to create a shared vision among major economies regarding the pathway to clean, reliable, resilient, and affordable power. Endorsing governments have created core principles and challenge propositions as a framework for government and industry action to support and guide power system transformation. This brochure details the status of the Challenge, how countries are working to meet the Challenge, and the relevant milestones reached by initiatives of the Clean Energy Ministerial.

Highlights of the 8th International Veterinary Immunology Symposium

Science.gov (United States)

Veterinary immunologists have expanded understanding of the immune systems for our companion animals and developed new vaccines and therapeutics. This manuscript summarizes the highlights of the 8th International Veterinary Immunology Symposium (8 th IVIS) held August 15th-19th, 2007, in Ouro Preto,...

231Pa and 230Th in the ocean model of the Community Earth System Model (CESM1.3)

Science.gov (United States)

Gu, Sifan; Liu, Zhengyu

2017-12-01

The sediment 231Pa / 230Th activity ratio is emerging as an important proxy for deep ocean circulation in the past. In order to allow for a direct model-data comparison and to improve our understanding of the sediment 231Pa / 230Th activity ratio, we implement 231Pa and 230Th in the ocean component of the Community Earth System Model (CESM). In addition to the fully coupled implementation of the scavenging behavior of 231Pa and 230Th with the active marine ecosystem module (particle-coupled: hereafter p-coupled), another form of 231Pa and 230Th have also been implemented with prescribed particle flux fields of the present climate (particle-fixed: hereafter p-fixed). The comparison of the two forms of 231Pa and 230Th helps to isolate the influence of the particle fluxes from that of ocean circulation. Under present-day climate forcing, our model is able to simulate water column 231Pa and 230Th activity and the sediment 231Pa / 230Th activity ratio in good agreement with available observations. In addition, in response to freshwater forcing, the p-coupled and p-fixed sediment 231Pa / 230Th activity ratios behave similarly over large areas of low productivity on long timescales, but can differ substantially in some regions of high productivity and on short timescales, indicating the importance of biological productivity in addition to ocean transport. Therefore, our model provides a potentially powerful tool to help the interpretation of sediment 231Pa / 230Th reconstructions and to improve our understanding of past ocean circulation and climate changes.

Influence of Radix scutellariae on Th1/Th2 cytokine balance in RU486-induced abortion in mice

Institute of Scientific and Technical Information of China (English)

ZHONG Xiuhui; SHI Wanyu; MA Aituan; WANG Xiaodan; ZHANG Jianlou; LI Xuezhong

2007-01-01

The aim of this study is to investigate the significance of Th1/Th2 cytokine balance in the uterus in the early embryo loss(or resorption),and to elucidate immunological modulation at the maternal-fetal interface with Chinese herbal medicine Radix scutellariae(Huang Qin)and its constituents(Baicalin and Baicalein).Mifepristone(RU486)was given via subcutaneous injection in the scapular area to induce abortion in mice at day 7 of gestation.The levels of uterine Thl cytokines(IFN-β,IL-2)and Th2 cytokines(IL-4,IL-10)were analyzed by enzyme-linked immunosorbent assay(ELISA),respectively.The mean values of Thl cytokines in the uterus of RU486-treated abortion mice were significantly higher(P＜0.05)than that of the control mice,but no significant difference was observed regarding to the contents of Th2 cytokines of different groups(P＞0.05).However,when the Radix scutellariae and its constituents were used to prevent RU486-induced abortion,the levels of IFN-γ and IL-2 decreased while that of IL-4 and IL-10 increased.The embryo loss induced by RU486 was closely related to the Th1/Th2 immune balance at the maternal-fetal interface.Radix scutellariae and its constituents have an anti-abortive effect through restoring the Th1/Th2 balance at the maternal-fetal interface.

Chemical ordering in substituted fluorite oxides: a computational investigation of Ho2Zr2O7 and RE2Th2O7 (RE=Ho, Y, Gd, Nd, La)

Science.gov (United States)

Solomon, Jonathan M.; Shamblin, Jacob; Lang, Maik; Navrotsky, Alexandra; Asta, Mark

2016-12-01

Fluorite-structured oxides find widespread use for applications spanning nuclear energy and waste containment, energy conversion, and sensing. In such applications the host tetravalent cation is often partially substituted by trivalent cations, with an associated formation of charge-compensating oxygen vacancies. The stability and properties of such materials are known to be influenced strongly by chemical ordering of the cations and vacancies, and the nature of such ordering and associated energetics are thus of considerable interest. Here we employ density-functional theory (DFT) calculations to study the structure and energetics of cation and oxygen-vacancy ordering in Ho2Zr2O7. In a recent neutron total scattering study, solid solutions in this system were reported to feature local chemical ordering based on the fluorite-derivative weberite structure. The calculations show a preferred chemical ordering qualitatively consistent with these findings, and yield values for the ordering energy of 9.5 kJ/mol-cation. Similar DFT calculations are applied to additional RE2Th2O7 fluorite compounds, spanning a range of values for the ratio of the tetravalent and trivalent (RE) cation radii. The results demonstrate that weberite-type order becomes destabilized with increasing values of this size ratio, consistent with an increasing energetic preference for the tetravalent cations to have higher oxygen coordination.

Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro

International Nuclear Information System (INIS)

Yang, Xia; Qian, Feng; He, Hai-Yang; Liu, Kai-Jun; Lan, Yuan-Zhi; Ni, Bing; Tian, Yi; Fu, Xiao-Lan; Zhang, Ji; Shen, Zi-Gang; Li, Jian; Yin, Yi; Li, Jin-Tao; Wu, Yu-Zhang

2011-01-01

Thymosin alpha 1 (Tα1) has been shown to have beneficial effects on numerous immune system parameters, but little is known about the effects of Tα1 on patients with gastric carcinoma. The objective of this study was to determine the effect of Tα1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro, and to evaluate its efficacy as an immunoregulatory factor in patients with gastric carcinoma. We compared the effect of Tα1 on the frequency of CD4 + and CD8 + T cells, especially the CD4 + CD25 + Foxp3 + Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22). We also analyzed the changes in the proliferation of PBMCs in response to treatment with Tα1, and examined the production of Th1, Th2, and Th17 cytokines by PBMCs and tumor-infiltrating lymphocytes. The treatment of PBMCs from gastric cancer patients, with Tα1 (50 µg/mL) alone increased the percentage of CD4+CD25+Foxp3+ (suppressive antitumor-specific Tregs) from 1.68 ± 0.697 to 2.19 ± 0.795% (P < 0.05). Our results indicate that Tα1 increases the percentage of Tregs and IL-1β, TNF-α, and IL-6 in vitro

Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro

Energy Technology Data Exchange (ETDEWEB)

Yang, Xia [Institute of Immunology,Third Military Medical University, Chongqing (China); Qian, Feng [Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing (China); He, Hai-Yang; Liu, Kai-Jun [Institute of Immunology,Third Military Medical University, Chongqing (China); Lan, Yuan-Zhi [Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing (China); Ni, Bing; Tian, Yi; Fu, Xiao-Lan; Zhang, Ji; Shen, Zi-Gang; Li, Jian; Yin, Yi; Li, Jin-Tao; Wu, Yu-Zhang [Institute of Immunology,Third Military Medical University, Chongqing (China)

2011-12-02

Thymosin alpha 1 (Tα1) has been shown to have beneficial effects on numerous immune system parameters, but little is known about the effects of Tα1 on patients with gastric carcinoma. The objective of this study was to determine the effect of Tα1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro, and to evaluate its efficacy as an immunoregulatory factor in patients with gastric carcinoma. We compared the effect of Tα1 on the frequency of CD4{sup +} and CD8{sup +} T cells, especially the CD4{sup +}CD25{sup +}Foxp3{sup +} Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22). We also analyzed the changes in the proliferation of PBMCs in response to treatment with Tα1, and examined the production of Th1, Th2, and Th17 cytokines by PBMCs and tumor-infiltrating lymphocytes. The treatment of PBMCs from gastric cancer patients, with Tα1 (50 µg/mL) alone increased the percentage of CD4+CD25+Foxp3+ (suppressive antitumor-specific Tregs) from 1.68 ± 0.697 to 2.19 ± 0.795% (P < 0.05). Our results indicate that Tα1 increases the percentage of Tregs and IL-1β, TNF-α, and IL-6 in vitro.

Public health and social supervision issues within public administration of ukrainian territories in the late 8th- early 9th centuries.

Science.gov (United States)

Hrynzovskyi, Anatolii M; Holovanova, Irina A; Omelchuk, Sergei T; Kuzminska, Olena V; Hrynzovska, Anastasia A; Karlova, Olena O; Kondratiuk, Vitalii Ye

Introduction: The public health system modernization history is based upon the progress in state country administration and administration of healthcare within the sectorwide approach. The WHO European Bureau pays much attention to the National Health Service systems development while implementing their basic policies. The Ukrainian state health service management was founded basing on the regulatory field of the Russian Empire, using the European healthcare promotion experience. Aim: of the article is the analysis of the regulatory field of police and amenity authorities of the Russian Empire and Ukraine within the medical and social service in the 18th-19th centuries. Materials and methods: The structure of the article corresponds to the problem city and chronology principles, using the following methods and techniques of scientific learning: the systemic, historic, regulatory comparative, logical and structural-functional analysis of the studied medical-legal phenomena. The study sources are the scientific publications, collections of laws and executive orders of the Russian Empire and Ukraine in the 18th-19th centuries. Review: As a result of the performed work it can be determined were the main directions of the police competence in late 18th- early 19th centuries. Conclusion: Preserving health, treatment of the ill and injured, management of medical and social service of those in need, holding various preventive activities and supporting safe environment and regulating the safety of food were the main directions of the police competence in late 18th- early 19th centuries.

Irradiation experiments of 3rd, 4th and 5th fuel assemblies by an in-pile gas loop, OGL-1

International Nuclear Information System (INIS)

Fukuda, Kousaku; Kobayashi, Fumiaki; Hayashi, Kimio; Minato, Kazuo; Kikuchi, Teruo; Adachi, Mamoru; Iwamoto, Kazumi; Ikawa, Katsuichi; Itami, Hiroharu.

1986-07-01

Three irradiation experiments for 3rd, 4th and 5th fuel assemblies which had been composed of VHTR reference coated particle fuels and graphite components were carried out by an in-pile gas loop, OGL-1 during 1979 and 1982. The main purposes of these experiments were to study on bowing of the fuel rod by irradiation for the 3rd fuel assembly, to study on fuel behavior under relatively low burnup irradiation for the 4th fuel assembly, and to study on fuel behavior up to full burnup of VHTR design for the 5th fuel assembly. For understanding in-pile fuel behavior, fractional releases of fission gases from each fuel assembly were estimated by measuring the fission gas concentrations in the primary loop of OGL-1. The post-irradiation examination (PIE) was carried out extensively on the fuel block, the fuel rods and the fuel compacts in Tokai Hot Laboratory. Also, made were the measurements of metallic fission product distributions in the fuel assemblies and the fuel rods. The results in these experiments were given as follows ; bowing of the fuel rod in the 3rd fuel assembly was 0.7 mm, but integrity of the rod was kept under irradiation. Fractional release of the fission gas from the 4th fuel assembly remained in the order of 10 -7 during irradiation, suggesting that the fuel performance was excellent. The fractional release from the 5th fuel assembly, on the other hand, was in the order of 10 -5 which was the same level in the VHTR design. (author)

Structural and thermodynamic study of the system Th-C-N in the presence of excess graphite; the existence of a new hexagonal phase β 'ThCN' stable at high temperature

International Nuclear Information System (INIS)

Pialoux, A.

1980-01-01

The progressive reaction of nitrogen on the 'dicarbide' of thorium in the presence of excess graphite has been studied using X-ray diffractometry at high temperature (T 0 C) under controlled pressure (10 -3 0 C using measurements of crystalline parameters, equilibrium pressures and free enthalpies of standard formation of the various carbonitrides and nitrides observed. It is notably shown that the 'dicarbide' in stable at psub(N2)'s considerably weaker than those stated by Benz and Froxel, the nitrogen content of the γ Th C 2 ' cubic phase increasing furthermore with temperature. The new β 'ThCN' phase which does not quench crystallizes in the hexagonal system and in reattatched to the group space with P31 m, the various contractions of tis crystalline parameter Csub(β) is interpreted as a closing of the double bond of the C 2 pairs in this structure. The temperature of 1125 0 C is attributed to the new polymorphic transformation: β 'ThCN' hexagonal reversible α 'ThCN' monoclinic which appear to be of the martensitic type, the crystalline parameters of α'ThCN' being furthermore measured from 20 to 1125 0 C. (orig.)

2015 Special Sessions of the 13th International Conference on Practical Applications of Agents and Multi-Agent Systems

CERN Document Server

Hernández, Josefa; Mathieu, Philippe; Campbell, Andrew; Fernández-Caballero, Antonio; Moreno, María; Julián, Vicente; Alonso-Betanzos, Amparo; Jiménez-López, María; Botti, Vicente; Trends in Practical Applications of Agents, Multi-Agent Systems and Sustainability : the PAAMS Collection

2015-01-01

This volume presents the papers that have been accepted for the 2015 special sessions of the 13th International Conference on Practical Applications of Agents and Multi-Agent Systems, held at University of Salamanca, Spain, at 3rd-5th June, 2015: Agents Behaviours and Artificial Markets (ABAM); Agents and Mobile Devices (AM); Multi-Agent Systems and Ambient Intelligence (MASMAI); Web Mining and Recommender systems (WebMiRes); Learning, Agents and Formal Languages (LAFLang); Agent-based Modeling of Sustainable Behavior and Green Economies (AMSBGE); Emotional Software Agents (SSESA) and Intelligent Educational Systems (SSIES). The volume also includes the paper accepted for the Doctoral Consortium in PAAMS 2015. PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems is an evolution of the International Workshop on Practical Applications of Agents and Multi-Agent Systems. PAAMS is an international yearly tribune to present, to discuss, and to disseminate the latest develo...

On the Th internal contamination of animals

International Nuclear Information System (INIS)

Ciubotariu, M.; Danis, A.; Dumitrescu, G.

2000-01-01

Fissionable elements (U,Th) internal contamination have been studied using the fission track method as analysis method of the U and/or Th contaminant elements and Wistar-London breed rats as experiment animals. In our previous studies on the Th internal contamination, we investigated the Th biodistribution and retention in all the vital organs of the contaminated rats. In this stage, we continued this study with the Th elimination investigation through urine and excrements. The identical aliquot parts of a solution calibrated in Th, corresponding to an Annual Limit Intake, three Wistar-London breed rats were contaminated. They were kept in normal life conditions and under permanent medical surveillance up to their sacrifice. The animals were sacrificed at different time intervals after their contamination: RAT 1 = 2 days, RAT 2 = 7 days and RAT 3 = 14 days, respectively. After the sacrifice, their vital organs were sampled, weighed, calcined, re-weighed and finally analysed by track detection using the fission track micro-mappings technique. The evacuations were sampled every 24 hours: urine, on the filter paper, and all excrements balls. The samples were weighed before and after calcination and analysed in the same way as the vital organs. The Th fission track micro-mappings technique was used in the following conditions: - mica-muscovite as track detector pre-etched for fossil tracks 18 h in HF-40 per cent at room temperature; - the neutron irradiations were performed in the nuclear reactor WWR-S Bucharest at the neutron fluences of 3·10 15 - 2·10 16 fast neutrons/cm 2 ; - the visualization of the Th induced fission tracks was obtained by chemical etching in HF-40 %, 3 h at room temperature; - the Th track micromappings obtained in track detectors were studied by optical microscopy using a stereo microscope WILD M7S for ensemble study (X6-X31) and a binocular Zeiss JENA microscope for qualitative and quantitative studies (X150). The investigation of the Th

Modulation of immune cells and Th1/Th2 cytokines in insulin-treated ...

African Journals Online (AJOL)

and Th2 cytokines and the frequencies of innate and adaptive immunity cells .... As inclusion criteria, all participants were non- .... Ranges of normal values: Fasting glucose: 3.88-6.10 mM (0.7-1.10 g/L); .... of HbA1c, reflecting a poor control of diabetes37 and a .... rophage recruitment and adipose tissue inflammation in.

Concentration of thorium isotopes and the activity ratios of 230Th/232Th and 228Th/232Th in seawater in the Pacific Ocean

International Nuclear Information System (INIS)

Miyake, Yasuo; Sugimura, Yukio; Yasujima, Tadahide.

1978-01-01

The concentration of thorium isotopes and the activity ratios of 230 Th/ 232 Th and 228 Th/ 232 Th in 500 l sea water samples collected in the Pacific Ocean were determined. Thorium isotopes were analyzed by alpha-ray spectrometry after separating them from other elements with an anion exchange resin. The average content of thorium ( 232 Th) of 0.9 ng l -1 was obtained in the open Pacific water. The average contents of 230 Th and 228 Th were 2.1 x 10 -2 pgl -1 and 1.2 agl -1 respectively. It was found that the ratios of 230 Th/ 232 Th and 228 Th/ 232 Th ranged respectively from 1.0 to 29, and from 0.4 to as high as 128. (author)

Th1/Th2 cytokine expression in diabetic retinopathy.

Science.gov (United States)

Cao, Y L; Zhang, F Q; Hao, F Q

2016-07-15

Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients with type 2 DM (T2DM group) without DR, and 30 cases of T2DM patients with DR (DR group). Real-time PCR was used to measure mRNA expression of IL-2 and TNF-α, secreted from Th1 cells, and of IL-4 and IL-10, secreted from Th2 cells. We used ELISA to detect cytokine expression in serum to analyze the correlation between Th1 and Th2 cytokines. IL-2 and TNF-αmRNA and protein expression levels in the T2DM and DR groups were significantly higher than in the normal control group (P 0.05). IL-2 and TNF-αwere negatively correlated with IL-4 and IL-10 in the DR group, respectively. We found that Th1 cytokine secretion was higher and Th2 cytokines secretion was lower during DR, leading to a Th1/ Th2 imbalance, suggesting that Th1/Th2 imbalance is a side effect for DR occurrence and development.

Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS.

Science.gov (United States)

Tappuni, A R; Shiboski, C

2016-04-01

The Research Agenda generated by the 7th World Workshop on Oral Health and Disease in AIDS (WW7) is delivered in this paper. Panels of international experts presided over nine workshops that constituted the conference held in November 2014 in Hyderabad, India. The main goal of the Workshop was to bring together clinician and scientists interested in the subject to debate with world-wide perspectives current issues related to the oral manifestations in HIV/AIDS. The workshops were structured around three themes; basic science, clinical/translational science and social science and were attended by 135 participants from 31 countries. The research questions debated at the workshops are presented in nine consensus papers published in this issue and are summarised in this paper along with an outline of the identified research needs in the field. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy

Directory of Open Access Journals (Sweden)

Julia Terhune

2013-11-01

Full Text Available The success of cellular immunotherapies against cancer requires the generation of activated CD4+ and CD8+ T-cells. The type of T-cell response generated (e.g., Th1 or Th2 will determine the efficacy of the therapy, and it is generally assumed that a type-1 response is needed for optimal cancer treatment. IL-17 producing T-cells (Th17/Tc17 play an important role in autoimmune diseases, but their function in cancer is more controversial. While some studies have shown a pro-cancerous role for IL-17, other studies have shown an anti-tumor function. The induction of polarized T-cell responses can be regulated by dendritic cells (DCs. DCs are key regulators of the immune system with the ability to affect both innate and adaptive immune responses. These properties have led many researchers to study the use of ex vivo manipulated DCs for the treatment of various diseases, such as cancer and autoimmune diseases. While Th1/Tc1 cells are traditionally used for their potent anti-tumor responses, mounting evidence suggests Th17/Tc17 cells should be utilized by themselves or for the induction of optimal Th1 responses. It is therefore important to understand the factors involved in the induction of both type-1 and type-17 T-cell responses by DCs.

Statement of nuclear incidents (1st. Qtr. 1990)

International Nuclear Information System (INIS)

1990-06-01

Only one incident was reported; at Bradwell nuclear power station, where there was a leak of carbon dioxide gas. No radioactive contamination was detected and the amount of gas released was well within operating levels. (UK)

13th Annual Systems Engineering Conference: Tues- Wed

Science.gov (United States)

2010-10-28

afknprod/ASPs/Reg/ GroupAdmin.asp?Filter=23843&EventID=1464 7 &GroupID=19841 No-Host Social, 1700-1900 Hamlet Restaurant I n t e g r i t y - S e r v i c e...Engineering Relationship Between SE and other Disciplines Systems People • Behaviours (The Head) – Understanding system concepts and viewpoints...level, and used/ consumed by SEs at both the SoS and single system level in the process of developing, maintaining, enhancing, deploying, and assessing

12th International Conference on Intelligent Autonomous Systems (IAS-12)

CERN Document Server

Yoon, Kwang-Joon; Lee, Jangmyung; Frontiers of Intelligent Autonomous Systems

2013-01-01

This carefully edited volume aims at providing readers with the most recent progress on intelligent autonomous systems, with its particular emphasis on intelligent autonomous ground, aerial and underwater vehicles as well as service robots for home and healthcare under the context of the aforementioned convergence. “Frontiers of Intelligent Autonomous Systems” includes thoroughly revised and extended papers selected from the 12th International Conference on Intelligent Autonomous Systems (IAS-12), held in Jeju, Korea, June 26-29, 2012. The editors chose 35 papers out of the 202 papers presented at IAS-12 which are organized into three chapters: Chapter 1 is dedicated to autonomous navigation and mobile manipulation, Chapter 2 to unmanned aerial and underwater vehicles and Chapter 3 to service robots for home and healthcare. To help the readers to easily access this volume, each chapter starts with a chapter summary introduced by one of the editors: Chapter 1 by Sukhan Lee, Chapter 2 by Kwang Joon Yoon and...

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

DEFF Research Database (Denmark)

Kleinnijenhuis, Johanneke; Quintin, Jessica; Preijers, Frank

2013-01-01

'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months...... in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained...... changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. © 2013 S. Karger AG, Basel....

Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses.

Science.gov (United States)

Ye, Zi; Deng, Bolin; Wang, Chaokui; Zhang, Dike; Kijlstra, Aize; Yang, Peizeng

2016-02-04

Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In this study, we investigated whether BTLA activation could be exploited to inhibit the development of abnormal immune responses in BD patients. BTLA expression in PBMCs and CD4(+) T cells was significantly decreased in active BD patients. Decreased BTLA level was associated with increased Th17 and Th1 responses. Activation of BTLA inhibited the abnormal Th17 and Th1 responses and IL-22 expression in both patients and controls. Addition of an agonistic anti-BTLA antibody remarkably inhibited DC-induced Th17 and Th1 cell responses, resulted in decreased production of the Th17 and Th1-related cytokines IL-1beta, IL-6, IL-23 and IL-12p70 and reduced CD40 expression in DCs. In conclusion, decreased BTLA expression in ocular BD may lead to inappropriate control of the Th17 and Th1 immune responses and DC functions. Therefore, BTLA may be involved in the development and recurrence of this disease. Agonistic agents of BTLA may represent a potential therapeutic approach for the treatment of BD and other inflammatory diseases mediated by abnormal Th17 and Th1 immune responses.

Evaluation of the AJCC 8th Edition Staging System for Pathologically Versus Clinically Staged Intrahepatic Cholangiocarcinoma (iCCA): a Time to Revisit a Dogma? A Surveillance, Epidemiology, and End Results (SEER) Analysis.

Science.gov (United States)

Kamarajah, Sivesh K

2018-03-07

Recently, the AJCC has released its 8th edition changes to the staging system for intrahepatic cholangiocarcinoma (iCCA). This study sought to validate the proposed changes to the 8th edition of AJCC system for T and N classification of iCCA using a population-based data set. Using the Surveillance, Epidemiology, and End Results (SEER) database (1998-2013), patients undergoing resection or non-surgical management for non-metastatic iCCA were identified. Overall survival was estimated using the Kaplan-Meier method and compared using log-rank tests. Concordance indices (c-indices) calculated from Cox proportional hazards models were calculated to evaluate discriminatory power. The study included 2630 patients resected (37%) or non-surgically managed (63%) for iCCA. Nodal staging was performed in 56%, of whom 31% had positive nodes. For all patients with iCCA, the median 5-year survival by AJCC T classification for T1a, T1b, T2, T3, and T4 was 32, 21, 14, 10, and 10 months, respectively (p < 0.001). The concordance index for the staging system was 0.57 for all patients, 0.62 for those who underwent resection, and 0.54 for patients who did not undergo resection. In summary, the new AJCC 8th edition staging system is comparable to the 7th edition and valid in stratifying patients with iCCA. However, the performance of the staging system is better in patients undergoing surgical resection than those undergoing non-surgical management. These findings further highlight the need for improved accuracy of radiological imaging in clinically staging patients to guide prognosis.

Thermodynamic assessment of the LiF–NaF–BeF{sub 2}–ThF{sub 4}–UF{sub 4} system

Energy Technology Data Exchange (ETDEWEB)

Capelli, E.; Beneš, O., E-mail: ondrej.benes@ec.europa.eu; Konings, R.J.M.

2014-06-01

The present study describes the full thermodynamic assessment of the LiF–NaF–BeF{sub 2}–ThF{sub 4}–UF{sub 4} system which is one of the key systems considered for a molten salt reactor fuel. The work is an extension of the previously assessed LiF–NaF–ThF{sub 4}–UF{sub 4} system with addition of BeF{sub 2} which is characterized by very low neutron capture cross section and a relatively low melting point. To extend the database the binary BeF{sub 2}–ThF{sub 4} and BeF{sub 2}–UF{sub 4} systems were optimized and the novel data were used for the thermodynamic assessment of BeF{sub 2} containing ternary systems for which experimental data exist in the literature. The obtained database is used to optimize the molten salt reactor fuel composition and to assess its properties with the emphasis on the melting behaviour.

MURPHYS-HSFS-2014: 7th International Workshop on MUlti-Rate Processes and HYSteresis (MURPHYS) and the 2nd International Workshop on Hysteresis and Slow-Fast Systems (HSFS)

International Nuclear Information System (INIS)

2016-01-01

Foreword MURPHYS-HSFS-2014 was the 7th International Workshop on MUlti-Rate Processes and HYSteresis (MURPHYS) in conjunction with the 2nd International Workshop on Hysteresis and Slow-Fast Systems (HSFS) . It took place at the Weierstrass Institute for Applied Analysis and Stochastics (WIAS), Berlin, Germany, from April 7 to April 11 in 2014. The international workshop on “Multi-Rate Processes and Hysteresis” continued a series of biennial conferences (Cork, Ireland, 2002-2008; Pecs, Hungary, 2010; Suceava, Romania, 2012) and the international workshop on “Hysteresis and Slow-Fast Systems” was the follow-up of the HSFS-workshop that had taken place in Lutherstadt Wittenberg, Germany, in 2011. More then 60 scientists from nine European countries and from the USA participated in MURPHYS-HSFS-2014. The program of the workshop featured 49 talks, including 15 main lectures and 15 invited talks. Recent mathematical results for systems with hysteresis operators, multiple scale systems, rate-independent systems, systems with energetic solutions, singularly perturbed systems, and systems with stochastic effects were presented. The considered applications included magnetization dynamics, biological systems, smart materials, networks, ferroelectric and ferroelastic hysteresis, fatigue in materials, market models with hysteresis, biomedical applications, chemical reactions, noise-induced phenomena, partially saturated soils, colloidal films and evaporation of automotive fuel droplets. Statement of Peer Review: All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. International steering committee: E. Benoit (France), M. Brokate (Germany), R. Cross (UK), K. Dahmen (USA), M. Dimian (Romania), M. Eleuteri (Italy), G. Friedman (USA

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

Science.gov (United States)

Basdeo, Sharee A; Cluxton, Deborah; Sulaimani, Jamal; Moran, Barry; Canavan, Mary; Orr, Carl; Veale, Douglas J; Fearon, Ursula; Fletcher, Jean M

2017-03-15

Th17 cells are an important therapeutic target in autoimmunity. However, it is known that Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation. Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in terms of their function and regulation, and whether they have a pathogenic role in autoimmunity. We compared the phenotypic and functional features of human Th17, Th1, and ex-Th17 cell populations. Our data showed that despite their loss of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proinflammatory cytokines. The proliferative brake on Th17 cells appeared to be lifted because ex-Th17 cells proliferated more than Th17 cells after stimulation. In contrast with Th1 and Th17 cells, ex-Th17 cells were highly resistant to suppression of proliferation and cytokines by regulatory T cells. Finally, we showed that ex-Th17 cells accumulated in the joints of rheumatoid arthritis patients. Taken together, these data indicate that human ex-Th17 cells are functionally distinct from Th1 and Th17 cells, and suggest that they may play a pathogenic role at sites of autoimmunity, such as the rheumatoid arthritis joint where they accumulate. These findings have implications for therapeutic strategies that target IL-17, because these may not inhibit pathogenic ex-Th17 cells. Copyright © 2017 by The American Association of Immunologists, Inc.

CLIMA 2016 - proceedings of the 12th REHVA World Congress

DEFF Research Database (Denmark)

CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies"....

The reliability, validity and responsiveness of the Thai version of Systemic Lupus Erythematosus Quality of Life (SLEQOL-TH) instrument.

Science.gov (United States)

Kasitanon, N; Wangkaew, S; Puntana, S; Sukitawut, W; Leong, K P; Louthrenoo, W

2013-03-01

The English version of the Systemic Lupus Erythematosus Quality of Life Questionnaire (SLEQOL) is a validated disease-specific quality of life instrument. The aim of this study was to evaluate the psychometric properties of the Thai version of the SLEQOL (SLEQOL-TH). Two independent translators translated the SLEQOL into Thai. The back translation of this version was performed by two other independent translators. The final version, SLEQOL-TH, was completed after resolving the discrepancies revealed by the back translation. One hundred and nine patients with SLE were enrolled to test the reliability, construct validity, floor and ceiling effects, and sensitivity to the changes of the SLEQOL-TH at six months. The differential item functioning (DIF) between the Thai and English versions was analyzed using the partial gamma. The internal consistency of the SLEQOL-TH was satisfactory with the overall Cronbach's alpha of 0.86. The test-retest reliability of the SLEQOL-TH was acceptable with the intra-class correlation coefficient of 0.86. Low correlations between the SLEQOL-TH and SLEDAI were observed. The total score of the SLEQOL-TH was moderately responsive to changes in quality of life, with a standardized response mean of 0.50. When comparing the SLEQOL-TH from Thai SLE patients with the original SLEQOL version obtained from Singapore SLE patients, 11 out of 40 items showed a moderate to large DIF. The SLEQOL-TH has acceptable psychometric properties and shows construct validity. In comparison with the English version of SLEQOL, there are some items that showed DIF. The applicability of the SLEQOL-TH in real-life clinical practice and clinical trials needs to be determined.

7th International Conference on Management Science and Engineering Management

CERN Document Server

Fry, John; Lev, Benjamin; Hajiyev, Asaf; Vol.I Focused on Electrical and Information Technology; Vol.II Focused on Electrical and Information Technology

2014-01-01

This book presents the proceedings of the Seventh International Conference on Management Science and Engineering Management (ICMSEM2013) held from November 7 to 9, 2013 at Drexel University, Philadelphia, Pennsylvania, USA and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Drexel University (Philadelphia, Pennsylvania, USA).   The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research findings. The selected papers cover various areas in management science and engineering management, such as Decision Support Systems, Multi-Objective Decisions, Uncertain Decisions, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic Models and Simulation, F...

Importance of coccolithophore-associated organic biopolymers for fractionating particle-reactive radionuclides (234Th, 233Pa, 210Pb, 210Po, and 7Be) in the ocean

Science.gov (United States)

Lin, Peng; Xu, Chen; Zhang, Saijin; Sun, Luni; Schwehr, Kathleen A.; Bretherton, Laura; Quigg, Antonietta; Santschi, Peter H.

2017-08-01

Laboratory incubation experiments using the coccolithophore Emiliania huxleyi were conducted in the presence of 234Th, 233Pa, 210Pb, 210Po, and 7Be to differentiate radionuclide uptake to the CaCO3 coccosphere from coccolithophore-associated biopolymers. The coccosphere (biogenic calcite exterior and its associated biopolymers), extracellular (nonattached and attached exopolymeric substances), and intracellular (sodium-dodecyl-sulfate extractable and Fe-Mn-associated metabolites) fractions were obtained by sequentially extraction after E. huxleyi reached its stationary growth phase. Radionuclide partitioning and the composition of different organic compound classes, including proteins, total carbohydrates (TCHO), and uronic acids (URA), were assessed. 210Po was closely associated with the more hydrophobic biopolymers (high protein/TCHO ratio, e.g., in attached exopolymeric substances), while 234Th and 233Pa showed similar partitioning behavior with most activity being distributed in URA-enriched, nonattached exopolymeric substances and intracellular biopolymers. 234Th and 233Pa were nearly undetectable in the coccosphere, with a minor abundance of organic components in the associated biopolymers. These findings provide solid evidence that biogenic calcite is not the actual main carrier phase for Th and Pa isotopes in the ocean. In contrast, both 210Pb and 7Be were found to be mostly concentrated in the CaCO3 coccosphere, likely substituting for Ca2+ during coccolith formation. Our results demonstrate that even small cells (E. huxleyi) can play an important role in the scavenging and fractionation of radionuclides. Furthermore, the distinct partitioning behavior of radionuclides in diatoms (previous studies) and coccolithophores (present study) explains the difference in the scavenging of radionuclides between diatom- and coccolithophore-dominated marine environments.

[Health-related assessment of the work training of 5-7th-form pupils].

Science.gov (United States)

Sorokina, A A

1990-09-01

The present investigation is devoted to the study of the influence of labour on the functional state of the organism of medium school-aged pupils. It has been found out that engagement of schoolchildren in the workships and study rooms of service labour are not tiring, which creates reserves for the active development of the motor functions of schoolchildren. At the same time it has been found out that the types of labour which they encounter for the first time (joinery in the 5th form, electrotechnical work) lead to unfavourable changes in the functional state of schoolchildren organisms. The data obtained in the course of investigation on the organization of labour lesson (density of working and lessons structure) have been used in the development of 'Concept of labour preparation of the rising generation and studying young people in the system of continuous education'.

Concentration of 232Th, 230Th and 228Th in various tissues of Japanese subjects

International Nuclear Information System (INIS)

Takizawa, Y.; Qingmei, H.; Hisamatsu, S.; Abe, T.

1997-01-01

The concentration of 232 Th, 230 Th and 228 Th in various human tissues of Japanese subjects obtained at autopsies are reported. The tissue samples were weighed, spiked with 234 Th tracer and ashed by acid. The solution was dried on a hot-plate. Separation of thorium radionuclides was accomplished through cation-exchange resin chromatography and electrodeposition. The concentrations of thorium isotopes were measured by α-spectrometry. Thorium-232 and 230 Th concentrations were found to be highest in lung, followed by bone. The maximum concentration of 228 Th was in bone. The lowest concentrations of thorium isotopes were in muscle. (author)

Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T. [Instituto de Pesquisas Energeticas e Nucleares, Av. Lineu Prestes, 2242, Caixa Postal 05508-000, Cidade Universitaria, Sao Paulo (Brazil)]. e-mail: Pscsilva@ipen.br

2004-07-01

In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. {sup 232} Th and {sup 228} Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. {sup 232} Th concentration ranged from 6.5 to 198 Bq kg{sup -1} with mean value of 57 {+-} 39 Bq kg{sup -1}, for 42 samples. {sup 228} Th content varied from 12 to 110 Bq kg{sup -1} with a mean value of 74 {+-} 23 Bq kg{sup -1}, for 18 samples. It can be seen that the amount of {sup 232} Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T.

2004-01-01

In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. 232 Th and 228 Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. 232 Th concentration ranged from 6.5 to 198 Bq kg -1 with mean value of 57 ± 39 Bq kg -1 , for 42 samples. 228 Th content varied from 12 to 110 Bq kg -1 with a mean value of 74 ± 23 Bq kg -1 , for 18 samples. It can be seen that the amount of 232 Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

Th biodistribution in internal contamination of animals

International Nuclear Information System (INIS)

Ciubotariu, M.; Danis, A.; Dumitrescu, G.; Cucu, M.

1999-01-01

Fissionable elements (U,Th) internal contamination have been studied using the fission track method as analysis method of the U and/or Th contaminant elements and Wistar-London breed rats as experiment animals. Different ways to obtain internal contaminations have been investigated: ingestion, inhalation, absorption by skin and through wounds. After the U internal contamination study was carried out, in this stage the Th internal contamination by ingestion is in progress. Using the identical aliquot parts of a solution calibrated in Th, corresponding to an Annual Limit Intake, three Wistar-London breed rats were contaminated. They were kept in normal life conditions and under permanent medical surveillance up to their sacrification. The animals were sacrificed at different time intervals after their contamination: 2 days, 7 days and 14 days, respectively. After the sacrification, their vital organs were sampled, weighed, calcined, re-weighed and finally analysed by track detection using the fission track micro-mappings technique. Also, their evacuations were sampled every 24 hours weighed, calcined and analysed in the same way as the vital organs. The Th fission track micro-mappings technique was used in the following conditions: - mica-muscovite as track detector pre-etched for fossil tracks 18 h in HF-40 per cent at room temperature; - the neutron irradiations were performed in the nuclear reactor VVR-S Bucharest at the neutron fluences of 3.10 15 - 2.10 16 fast neutrons/c m 2 ; - the visualization of the Th induced fission tracks were obtained by chemical etching in HF-40 per cent, 3 h at room temperature; - the Th track micro-mappings obtained in track detectors were studied by optical microscopy using a stereo microscope WILD M7S for ensemble study (X6-X31) and a binocular ZEISS JENA microscope for qualitative and quantitative studies (X150). The biological reference materials calibrated in Th were prepared in our laboratory using the calcined organs and the

7th Symposium on Computational Statistics

CERN Document Server

Lauro, N; Rizzi, A

1986-01-01

When dealing with the design or with the application of any technical system, which is not quite simple and trivial, one has to face to the problem to determine the allowable de­ viations of the system functions and the optimal vector of system parameter tolerances. The need for the solution of this problem is stimulated with various serious economic and maite­ nance aspects, between them the tendency to reach the minimal production cost, the maximal system operation reliability are the most frequent. Suppose that we are dealing with an system S, consisting of N components represented by the system parame­ ters xi' i = 1, 2 . . . N, which are arranged in certain structu­ re so, that the K, system functions F k' k = 1, 2 . . . IG , expres­ sing the considered system properties, fullfil the condition F-FO~ AF, /1/ \\'Ihere F = l F k} Ie is the set of the actual system functions, FO = lFOk}~ is the set of the nominal system functions and A F = l A F k 1(;. } is the set 0 f the a 11 0 w a b 1 e s emf y s t u ...

U-Th age evidence from carbonate veins for episodic crustal deformation of Central Anatolian Volcanic Province

Science.gov (United States)

Karabacak, Volkan; Uysal, I. Tonguç; Ünal-İmer, Ezgi; Mutlu, Halim; Zhao, Jian-xin

2017-12-01

Central Anatolia represents one of the most outstanding examples of intraplate deformation related to both continental collision and back-arc extension generating non-uniformly distributed stress fields. In this study, we provide direct field evidence of various stress directions and investigate carbonate-filled fracture systems in the Central Anatolian Volcanic Province using U/Th geochronology and isotope geochemistry for evaluating the episodes of latest volcanic activity under regional stress. Field data reveal two independent fracture systems in the region. Successive fracture development has been controlled by two different volcanic eruption centers (Hasandağ Composite Volcano and Acıgöl Caldera). Trace element, and stable (C and O) and radiogenic (Sr) isotope compositions of carbonate veins indicate different fluid migration pathways for two different fracture systems. The U/Th age data for carbonate veins of two independent fracture systems indicate that the crustal deformation intensified during 7 episodic periods in the last 150 ka. The NNE-trending first fracture system was formed as a result of strain cycles in a period from 149 ± 2.5, through 91 ± 1.5 to 83 ± 2.5 ka BP. Subsequent deformation events represented by the ENE-trending second fracture zone have been triggered during the period of 53 ± 3.5, 44 ± 0.6 and 34 ± 1 ka BP before the first fracture zone resumed the activity at about 4.7 ± 0.15 ka BP. Although further studies are needed to evaluate statistical significance of age correlations, the periods of carbonate precipitation inferred from U-Th age distributions in this study are comparable with the previous dating results of surrounding volcanic eruption events.

Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

Directory of Open Access Journals (Sweden)

A. Tincani

2012-12-01

Full Text Available This study evaluated some cytokines involved in the Th1-Th2 shift during pregnancy in patients with systemic lupus erythematosus (SLE and healthy women. Twenty-seven consecutive successful pregnancies in 26 SLE patients and 28 pregnancies in 28 matched healthy subjects, as controls, were enrolled and prospectively studied. Sera obtained at first and third trimesters of pregnancy were tested for IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, INF-γ, and TNF-α with a highly sensitive, multiplexed sandwich ELISA (SearchLight Human Inflammatory Cytokine Array. Statistics were performed by SPSS package. IL-8 serum levels were higher in the first (P<0.0001 and third (P=0.003 trimesters of pregnancy in SLE patients compared with controls, INF-γ serum levels in the third trimester (P=0.009, and IL-10 serum levels in the first and third trimesters (P=0.055 and P<0.0001, respectively. IL-2 (r=0.524 P=0.010, IL-12 (r=0.549 P=0.007, IFN-γ (r=0.492 P=0.017, and IL-6 (r=0.515 P=0.020 serum levels correlated with disease activity in SLE patients in the first trimester of pregnancy. Cytokine profile was similar in patients with and without lupus nephritis both in the first and in the third trimesters of pregnancy. IL-8 serum levels were lower in patients with a previous diagnosis of antiphospholipid antibody syndrome compared with those without, both in the first and in the third trimesters of pregnancy. In SLE patients, a lower than expected decrease in Th1 cytokine serum levels was observed in the third trimester of gestation which could contribute to a lower Th2 cytokine polarization during pregnancy.

Region 7 Laboratory Information Management System

Science.gov (United States)

This is metadata documentation for the Region 7 Laboratory Information Management System (R7LIMS) which maintains records for the Regional Laboratory. Any Laboratory analytical work performed is stored in this system which replaces LIMS-Lite, and before that LAST. The EPA and its contractors may use this database. The Office of Policy & Management (PLMG) Division at EPA Region 7 is the primary managing entity; contractors can access this database but it is not accessible to the public.

7th to 9th grade obese adolescents' perceptions about obesity in Tamaulipas, Mexico.

Science.gov (United States)

de la Luz Martínez-Aguilar, Ma; Flores-Peña, Yolanda; de las Mercedes Rizo-Baeza, Ma; Aguilar-Hernández, Rosa Ma; Vázquez-Galindo, Laura; Gutiérres-Sánchez, Gustavo

2010-01-01

The objective was to explore obese adolescents perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the hereditary factor as the main obesity cause, tended to underestimate obesity and had low self-esteem. They reported problems to do physical exercise and get clothes in order to improve their image, and feel rejected by their peers in school. It was identified that these adolescents have psychological defense mechanisms against obesity and that some of them are making efforts to lose weight. Obesity entails social and psychological health implications for persons suffering from this problem. Interventions should be put in practice.

12th International Conference on Computing and Information Technology

CERN Document Server

Boonkrong, Sirapat; Unger, Herwig

2016-01-01

This proceedings book presents recent research work and results in the area of communication and information technologies. The chapters of this book contain the main, well-selected and reviewed contributions of scientists who met at the 12th International Conference on Computing and Information Technology (IC2IT) held during 7th - 8th July 2016 in Khon Kaen, Thailand The book is divided into three parts: “User Centric Data Mining and Text Processing”, “Data Mining Algoritms and their Applications” and “Optimization of Complex Networks”.

Bronze flagon from Pontes with an inscription from the 29th Psalm of David

Directory of Open Access Journals (Sweden)

Popović Ivana

2015-01-01

Full Text Available During the campaign which took place in 1983 at the site of Pontes - Trajan’s Bridge near Kostol, in the layer between a house from the second half of the 9th century and a house from the 11th century, a treasury consisting of medieval iron tools placed around, or inserted into, a bronze flagon was discovered in a shallow pit. The whole find was named Treasury B. At first, the flagon itself was dated into the period between the 6th and the 8th centuries, however, we have recently dated it into the 6th-7th century. The inscription on the neck of the vessel is a paraphrase of the 3rd verse from the 29th Psalm of David. This is proof that the flagon was a liturgical vessel. In this text we are trying to show that this flagon was analogous to the specimen from the treasury from Vrap in Albania, whose deposition during the third part of the 7th century is connected with the activity of Bulgarian Khan Kuber. The Byzantine vessel was a part of treasure plundered from the Avars, and the production of this flagon, just as of that one from Pontes, can be dated into the period between the 6th century and the first half or the middle of the 7th century. [Projekat Ministarstva nauke Republike Srbije, br. 177007: Romanisation, urbanisation and transformation of urban centres of civil, military and residential character in Roman provinces in the territory of Serbia

The Aegean in the Early 7th Millennium BC: Maritime Networks and Colonization.

Science.gov (United States)

Horejs, B; Milić, B; Ostmann, F; Thanheiser, U; Weninger, B; Galik, A

The process of Near Eastern neolithization and its westward expansion from the core zone in the Levant and upper Mesopotamia has been broadly discussed in recent decades, and many models have been developed to describe the spread of early farming in terms of its timing, structure, geography and sociocultural impact. Until now, based on recent intensive investigations in northwestern and western Anatolia, the discussion has mainly centred on the importance of Anatolian inland routes for the westward spread of neolithization. This contribution focuses on the potential impact of east Mediterranean and Aegean maritime networks on the spread of the Neolithic lifestyle to the western edge of the Anatolian subcontinent in the earliest phases of sedentism. Employing the longue durée model and the concept of 'social memory', we will discuss the arrival of new groups via established maritime routes. The existence of maritime networks prior to the spread of farming is already indicated by the high mobility of Epipalaeolithic/Mesolithic groups exploring the Aegean and east Mediterranean seas, and reaching, for example, the Cyclades and Cyprus. Successful navigation by these early mobile groups across the open sea is attested by the distribution of Melian obsidian. The potential existence of an additional Pre-Pottery Neolithic (PPN) obsidian network that operated between Cappadocia/Cilicia and Cyprus further hints at the importance of maritime coastal trade. Since both the coastal and the high seas networks were apparently already well established in this early period, we may further assume appropriate knowledge of geographic routes, navigational technology and other aspects of successful seafaring. This Mesolithic/PPN maritime know-how package appears to have been used by later groups, in the early 7th millennium calBC, exploring the centre of the Anatolian Aegean coast, and in time establishing some of the first permanent settlements in that region. In the present paper, we

Proceedings: 9th World Congress on Preventive Dentistry (WCPD): "Community Participation and Global Alliances for Lifelong Oral Health for All," Phuket, Thailand, September 7-10, 2009

DEFF Research Database (Denmark)

Clarkson, J; Watt, R G; Rugg-Gunn, A J

2010-01-01

Information is presented about the 9th World Congress on Preventive Dentistry which was hosted by the International Association for Dental Research in Phuket, Thailand on September 7-10, 2009. The conference's theme, "Community Participation and Global Alliances for Lifelong Oral Health for All...

Nuclear science symposium, 26th and symposium on nuclear power systems, 11th, 1979

International Nuclear Information System (INIS)

Kerns, C.R.

1980-01-01

Proceedings include 163 of the papers presented at the combined meetings, as well as two papers delivered at the plenary session on plant control beyond the 1980's and ionizing radiation dose hazards. One-hundred-and-sixty-two papers are indexed separately. Nuclear Science symposium included calorimeters and specific ionization (17 papers); PWC and Drift Chambers (7 papers); photo/optical detectors (10 papers); semiconductor detectors (11 papers); nuclear circuits and systems (11 papers); space instrumentation (9 papers); medical instrumentation (30 papers); data preprocessing (6 papers); data acquisition (11 papers); environmental instrumentation (15 papers); reactor instrumentation (16 papers). Fifteen Nuclear Systems Symposium papers covered: safety, RFI effects, detectors, monitoring systems, reactor protection, multiplexing of circuits, standard application, emergency planning and preparedness and operator/instrumentation interactions

RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP).

Science.gov (United States)

Lin, Ying; Zhou, Xieming; Guo, Wenjian; Li, Qianqian; Pan, Xiahui; Bao, Yunhua; He, Muqing; Zhu, Baoling; Lin, Xiaoji; Jin, Limin; Yao, Rongxin

2016-09-01

Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by reduction in platelet counts. T helper 1 (Th1) cells polarization with an increased shift of Th1/Th2 ratio has been reported in ITP. This shift is associated with transcription factor T-box expressed in T cells (T-bet) upregulation and GATA-binding protein 3 (GATA-3) downregulation, leading to an increased T-bet/GATA-3 ratio. Our previous in vitro study showed that recombinant human interleukin-11 (rhIL-11) could normalize Th1/Th2 imbalance in the peripheral blood mononuclear cells (PBMCs) isolated from adult ITP patients, which co-occurred with T-bet/GATA-3 ratio restoration. In this report, we investigated whether rhIL-11 had therapeutic effect in clinical ITP patients and whether rhIL-11 treatment could normalize Th1/Th2 and T-bet/GATA-3 levels in vivo. We found rhIL-11 treatment had a response rate of 67.7% and significantly decreased Th1 and T-bet levels but increased Th2 and GATA-3 levels in ITP patients who showed good response, normalizing Th1/Th2 and T-bet/GATA-3 ratios similar to that in healthy controls. Thus our study suggested rhIL-11 was effective with tolerable adverse effects in ITP. The treatment strategy warrants further clinical investigation. Copyright © 2016 Elsevier B.V. All rights reserved.

Fission gas release from ThO2 and ThO2--UO2 fuels (LWBR development program)

International Nuclear Information System (INIS)

Goldberg, I.; Spahr, G.L.; White, L.S.; Waldman, L.A.; Giovengo, J.F.; Pfennigwerth, P.L.; Sherman, J.

1978-08-01

Fission gas release data are presented from 51 fuel rods irradiated as part of the LWBR irradiations test program. The fuel rods were Zircaloy-4 clad and contained ThO 2 or ThO 2 -UO 2 fuel pellets, with UO 2 compositions ranging from 2.0 to 24.7 weight percent and fuel densities ranging from 77.8 to 98.7 percent of theoretical. Rod diameters ranged from 0.25 to 0.71 inches and fuel active lengths ranged from 3 to 84 inches. Peak linear power outputs ranged from 2 to 22 kw/ft for peak fuel burnups up to 56,000 MWD/MTM. Measured fission gas release was quite low, ranging from 0.1 to 5.2 percent. Fission gas release was higher at higher temperature and burnup and was lower at higher initial fuel density. No sensitivity to UO 2 composition was evidenced

FY 1998 Report on development of technologies for commercialization of photovoltaic power systems. International co-operative project (IEA implementing agreement for a co-operative programme on photovoltaic power systems, 9th and 10th executive committee meetings); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu kokusai kyoryoku jigyo. IEA taiyoko hatsuden system kenkyu kyoryoku program jisshi kyotei dai 10 kai dai 9 kai iinkai

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Described herein are outline of the International Energy Agency/Co-operative programme on Photovoltaic Power Systems (IEA/PVPS), and minutes of the 9th and 10th executive committee meetings. Japan signed the IEA Implementing Agreement for a co-operative programme on Photovoltaic Power Systems in April 1993, and has been participating in the programme for research and development, demonstration, analysis, information exchange and introduction promotion, among others. The tasks are composed of exchange and dissemination of information on PVPS, operational performance and design of PVPS, use of PVPS in stand alone and island applications, grid interconnection of building integrated and other dispersed PVPS, design and grid interconnection of dispersed PVPS, e.g., roof type, design and operation of modular PV plants for large scale power generation, PV in the built environment, and feasibility study on large scale PV power generation utilizing desert areas. The 9th and 10th executive committee meetings include the co-operative programme progress reports and technical tours. (NEDO)

PREFACE: 7th International Conference on Applications of Physics in Financial Analysis

Science.gov (United States)

Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.

2010-04-01

This volume contains contributed papers from the 7th international conference on 'Applications of Physics in Financial Analysis (APFA)' held at Tokyo on 1-5 March 2009. The conference was organized jointly by Tokyo Institute of Technology and Hitotsubashi University with support from the Research Institute of Economy, Trade, and Industry (RIETI), Physical Society of Japan, Japanese Economic Association, Information Processing Society of Japan, Japanese Society for Artificial Intelligence, and Japan Association for Evolutionary Economics. The first APFA conference (APFA1) was held in 1999 at Dublin, followed by APFA2 at Liege in 2000, APFA3 at London in 2001, APFA4 at Warsaw in 2003, APFA5 at Torino in 2006, and APFA6 at Lisbon in 2007. The 7th APFA conference, which is the first meeting held outside Europe, was attended by 223 researchers in physics and economics from 23 countries world-wide. In keeping with past APFA conferences, we paid special attention to issues in financial markets, which turned out to be very timely. The conference was held in March 2009, in the middle of the global financial crisis that originally started in the US and spread quickly to every corner of the world. The topic of the conference is 'New Approaches to the Analysis of Large Scale Business and Economic data'. The rapid development of information and communication technology has enabled financial/non-financial firms to keep detailed records of their business activities in the form of, for example, tick-by-tick data in financial markets, point-of-sale (POS) data on individual household's purchasing activity, and interfirm network data describing relationships among firms in terms of suppliers/customers transactions and ownerships. This growth in the scope and amount of business data available to researchers has led to a far-reaching expansion in research possibilities. Researchers not only in social sciences but also in physics, mathematics, and information sciences have recently

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings

Directory of Open Access Journals (Sweden)

Mengzhou He

2018-01-01

Full Text Available Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, the underlying immunologic mechanisms that trigger pregnancy loss remain largely unelucidated. Galectin-9 (Gal-9 may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA/2-mated CBA/J mice to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs to explore how Gal-9 might be involved in the pathogenesis of abortion. We found that the expression levels of Gal-9 in abortion-prone matings were lower than that for controls. Using a coculture system, we detected a Th1 preponderance in the coculture from abortion-prone matings. Furthermore, Gal-9 blockade augmented the imbalance of Th1/Th2 immunity in abortion-prone matings by promoting the secretion of Th1-derived cytokines in coculture, while there was a Th2 preponderance when we administered recombinant Gal-9. In conclusion, our results suggest that the Gal-9 signal is important for the regulation of PBMC function toward a Th2 bias at the maternal-fetal interface, which is beneficial for the maintenance of a normal pregnancy.

Diagnostic performance of 64-section CT using CT gastrography in preoperative T staging of gastric cancer according to 7th edition of AJCC cancer staging manual

International Nuclear Information System (INIS)

Kim, Jin Woong; Shin, Sang Soo; Heo, Suk Hee; Lim, Hyo Soon; Jeong, Yong Yeon; Kang, Heoung Keun; Choi, Yoo Duk; Park, Young Kyu; Park, Chang Hwan

2012-01-01

To evaluate the accuracy of 64-section multidetector CT with CT gastrography for determining the depth of mural invasion in patients with gastric cancer according to the 7th edition of the AJCC cancer staging manual. A total of 127 patients with gastric cancer and who had undergone both esophago-gastro-duodenoscopy and 64-section CT were included in this study. Two radiologists independently reviewed the preoperative CT images with respect to the detectability and T-staging of the gastric cancers. The sensitivity, specificity, accuracy and overall accuracy of each reviewer for the T staging of gastric cancer were calculated. Overall, gastric cancer was detected in 123 (96.9%) of the 127 cancers on the CT images. Reviewer 1 correctly staged 98 gastric cancers, and reviewer 2 correctly classified 105 gastric cancers. The overall diagnostic accuracy of the T staging was 77.2% (98/127) for reviewer 1 and 82.7% (105/127) for reviewer 2. 64-section CT using CT gastrography showed a reasonable diagnostic performance for determining the T staging in patients with gastric cancer according to the 7th edition of the AJCC cancer staging manual. (orig.)

BioSTEC 2017: 10th International Joint Conference on Biomedical Engineering Systems and Technologies : Proceedings Volume 5: HealthInf

NARCIS (Netherlands)

2017-01-01

This book contains the proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2017). This conference is sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC), in cooperation with the ACM

Assessment of surface reactivity of thorium oxide in conditions close to chemical equilibrium by isotope exchange {sup 229}Th/{sup 232}Th method

Energy Technology Data Exchange (ETDEWEB)

Suzuki-Muresan, Tomo; Perrigaud, Katy; Vandenborre, Johan; Ribet, Solange; Grambow, Bernd [Nantes Univ., CNRS/IN2P3 (France). SUBATECH Unite Mixte de Recherche 6457; Takamasa, Inai [TOKAI Univ., Kanagawa (Japan)

2017-08-01

This work aims to assess the solubility and the surface reactivity of crystallized thorium at pH 3.0 in presence of three types of solids: synthesized powder at 1300 C, crushed kernel, and intact kernel. In this study, the kernel is composed by the core solid from high temperature reactors (HTR) sphere particles. The originality of this work consisted in following in a sequential order the kinetic of dissolution, the surface reactivity in presence of isotope tracer {sup 229}Th, and its desorption process. Long time experiments (634 days) allowed to get deeper understanding on the behavior of the surface reactivity in contact with the solution. Solubility values are ranging from 0.3 x 10{sup -7} mol.L{sup -1} to 3 x 10{sup -7} mol.L{sup -1} with a dissolution rate of 10{sup -6}-10{sup -4} g.m{sup -2} day{sup -1}. PHREEQC modeling showed that crystallized ThO{sub 2}(cr, 20 nm) phase controls the equilibrium in solution. Isotope exchange between {sup 229}Th and {sup 232}Th indicated that well-crystallized phase exist as an inert surface regarding to the absence of exchange between surface solid and solution.

OPNET simulation Signaling System No.7 (SS7) network interfaces

OpenAIRE

Ow, Kong Chung.

2000-01-01

This thesis presents an OPNET model and simulation of the Signaling System No.7 (SS7) network, which is dubbed the world's largest data communications network. The main focus of the study is to model one of its levels, the Message Transfer Part Level 3, in accordance with the ITU.T recommendation Q.704. An overview of SS7 that includes the evolution and basics of SS7 architecture is provided to familarize the reader with the topic. This includes the protocol stack, signaling points, signaling...

Germany after March 11th

International Nuclear Information System (INIS)

Wolski, A.

2011-01-01

A retrospective since March 11th is presented with stress on the Fukushima accident, political situation in Germany, media and public opinion. Fukushima has devastated the trust in expert opinions about safety of NPPs. Germany’s Turn in Energy - consensus for nuclear phase-out exists between All political parties. The government has already announced adoption of the recommendations of the ethics commission. The 7 oldest units will remain shut-down. Further 7 units will be shut down until 2021. The youngest 3 units will be permanently shut down until 2022

Nineth Rib Syndrome after 10(th) Rib Resection.

Science.gov (United States)

Yu, Hyun Jeong; Jeong, Yu Sub; Lee, Dong Hoon; Yim, Kyoung Hoon

2016-07-01

The 12(th) rib syndrome is a disease that causes pain between the upper abdomen and the lower chest. It is assumed that the impinging on the nerves between the ribs causes pain in the lower chest, upper abdomen, and flank. A 74-year-old female patient visited a pain clinic complaining of pain in her back, and left chest wall at a 7 on the 0-10 Numeric Rating scale (NRS). She had a lateral fixation at T12-L2, 6 years earlier. After the operation, she had multiple osteoporotic compression fractures. When the spine was bent, the patient complained about a sharp pain in the left mid-axillary line and radiating pain toward the abdomen. On physical examination, the 10(th) rib was not felt, and an image of the rib-cage confirmed that the left 10(th) rib was severed. When applying pressure from the legs to the 9(th) rib of the patient, pain was reproduced. Therefore, the patient was diagnosed with 9(th) rib syndrome, and ultrasound-guided 9(th) and 10(th) intercostal nerve blocks were performed around the tips of the severed 10(th) rib. In addition, local anesthetics with triamcinolone were administered into the muscles beneath the 9(th) rib at the point of the greatest tenderness. The patient's pain was reduced to NRS 2 point. In this case, it is suspected that the patient had a partial resection of the left 10(th) rib in the past, and subsequent compression fractures at T8 and T9 led to the deformation of the rib cage, causing the tip of the remaining 10(th) rib to impinge on the 9(th) intercostal nerves, causing pain.

Consensus report from the 7th International Forum for Liver Magnetic Resonance Imaging

Energy Technology Data Exchange (ETDEWEB)

Merkle, Elmar M.; Zech, Christoph J. [University Hospital Basel, Clinic of Radiology and Nuclear Medicine, Basel (Switzerland); Bartolozzi, Carlo [University of Pisa, Department of Radiology, Pisa (Italy); Bashir, Mustafa R. [Duke University Medical Center, Department of Radiology, Durham, NC (United States); Ba-Ssalamah, Ahmed [Medical University of Vienna, Department of General and Pediatric Radiology, Vienna (Austria); Huppertz, Alexander [Imaging Science Institute Charite, Berlin (Germany); Lee, Jeong Min [Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of); Ricke, Jens [Otto-von-Guericke Universitaet Magdeburg, Department of Radiology and Nuclear Medicine, Magdeburg (Germany); Sakamoto, Michiie [Keio University School of Medicine, Department of Pathology, Tokyo (Japan); Sirlin, Claude B. [University of California, Liver Imaging Group, Department of Radiology, San Diego, California (United States); Ye, Sheng-Long [Fudan University, Department of Hepatic Oncology, Zhongshan Hospital, Shanghai (China); Zeng, Mengsu [Fudan University, Radiologic Diagnostic Department, Zhongshan Hospital, Shanghai (China)

2016-03-15

Liver-specific MRI is a fast-growing field, with technological and protocol advancements providing more robust imaging and allowing a greater depth of information per examination. This article reports the evidence for, and expert thinking on, current challenges in liver-specific MRI, as discussed at the 7th International Forum for Liver MRI, which was held in Shanghai, China, in October 2013. Topics discussed included the role of gadoxetic acid-enhanced MRI in the differentiation of focal nodular hyperplasia from hepatocellular adenoma and small hepatocellular carcinoma (HCC) from small intrahepatic cholangiocarcinoma (in patients with chronic liver disease), the differentiation of low-grade dysplastic nodule (DN) from pre-malignant high-grade DN and early HCC, and treatment planning and assessment of treatment response for patients with HCC and colorectal liver metastasis. Optimization of the gadoxetic acid-enhanced MRI protocol to gain robust arterial and hepatobiliary phase images was also discussed. Gadoxetic acid-enhanced MRI demonstrates added value for the detection and characterization of focal liver lesions and shows promise in a number of new indications, including regional liver functional assessment and patient monitoring after therapy; however, more data are needed in some areas, and further developments are needed to translate cutting-edge techniques into clinical practice. (orig.)

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Science.gov (United States)

Mitchell, Ruth E; Hassan, Masriana; Burton, Bronwen R; Britton, Graham; Hill, Elaine V; Verhagen, Johan; Wraith, David C

2017-09-12

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4 + T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet + cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 cultures. These data demonstrate that IL-4 contributes to IL-10 production and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the cross-regulation of Th1 and Th2 cells. These findings are important in the context of Th1 driven diseases since they reveal how the Th1 phenotype and function can be modulated by IL-4.

C5a regulates IL-12+ DC migration to induce pathogenic Th1 and Th17 cells in sepsis.

Directory of Open Access Journals (Sweden)

Ning Ma

Full Text Available OBJECTIVE: It is well known that complement system C5a is excessively activated during the onset of sepsis. However, it is unclear whether C5a can regulate dentritic cells (DCs to stimulate adaptive immune cells such as Th1 and Th17 in sepsis. METHODS: Sepsis was induced by cecal ligation and puncture (CLP. CLP-induced sepsis was treated with anti-C5a or IL-12. IL-12(+DC, IFNγ(+Th1, and IL-17(+Th17 cells were analyzed by flow cytometry. IL-12 was measured by ELISA. RESULTS: Our studies here showed that C5a induced IL-12(+DC cell migration from the peritoneal cavity to peripheral blood and lymph nodes. Furthermore, IL-12(+DC cells induced the expansion of pathogenic IFNγ(+Th1 and IL-17(+Th17 cells in peripheral blood and lymph nodes. Moreover, IL-12, secreted by DC cells in the peritoneal cavity, is an important factor that prevents the development of sepsis. CONCLUSION: Our data suggests that C5a regulates IL-12(+DC cell migration to induce pathogenic Th1 and Th17 cells in sepsis.

Anti-retroviral therapy fails to restore the severe Th-17: Tc-17 imbalance observed in peripheral blood during simian immunodeficiency virus infection.

Science.gov (United States)

Kader, M; Bixler, S; Piatak, M; Lifson, J; Mattapallil, J J

2009-10-01

Human immuno deficiency virus and simian immunodeficiency virus infections are characterized by a severe loss of Th-17 cells (IL-17(+)CD4(+) T cells) that has been associated with disease progression and systemic dissemination of bacterial infections. Anti-retroviral therapy (ART) has led to repopulation of CD4(+) T cells in peripheral tissues with little sustainable repopulation in mucosal tissues. Given the central importance of Th-17 cells in mucosal homeostasis, it is not known if the failure of ART to permanently repopulate mucosal tissues is associated with a failure to restore Th-17 cells that are lost during infection. Dynamics of alpha4(+)beta7(hi) CD4(+) T cells in peripheral blood of SIV infected rhesus macaques were evaluated and compared to animals that were treated with ART. The frequency of Th-17 and Tc-17 cells was determined following infection and after therapy. Relative expression of IL-21, IL-23, and TGFbeta was determined using Taqman PCR. Treatment of SIV infected rhesus macaques with anti-retroviral therapy was associated with a substantial repopulation of mucosal homing alpha4(+)beta7(hi)CD4(+) T cells in peripheral blood. This repopulation, however, was not accompanied by a restoration of Th-17 responses. Interestingly, SIV infection was associated with an increase in Tc-17 responses (IL-17(+)CD8(+) T cells) suggesting to a skewing in the ratio of Th-17: Tc-17 cells from a predominantly Th-17 phenotype to a predominantly Tc-17 phenotype. Surprisingly, Tc-17 responses remained high during the course of therapy suggesting that ART failed to correct the imbalance in Th-17 : Tc-17 responses induced following SIV infection. ART was associated with substantial repopulation of alpha4(+)beta7(hi) CD4(+) T cells in peripheral blood with little or no rebound of Th-17 cells. On the other hand, repopulation of alpha4(+)beta7(hi) CD4(+) T cells was accompanied by persistence of high levels of Tc-17 cells in peripheral blood. The dysregulation of Th-17

Determination of 232Th, 230Th and 228Th in liquid effluents from uranium mining

International Nuclear Information System (INIS)

Godoy, Jose Marcus de Oliveira

1979-10-01

A liquid scintillator αlpha spectrometer was built for the determination of Th- 228 , Th- 230 and Th- 232 in liquid effluents from Uranium mines and mills. The resolution of the αlpha spectrometer was found to be 200-300 KeV, when the scintillator was 8% T0P0, 0,77% scintimix-4 (91% PP0 and 9% Dimetil-P0P0P) and 10% of naphthalene in toluene. Aliquat-336 in xylene (30% v/v) was used to separate the thorium isotopes from other interfering radionuclides (U- 238 , U- 234 , Ra- 226 , Po- 210 ). Under the extraction experimental conditions, the detection limits were 1,2 pCi/1 for Th- 232 , 1,2 pCi/1 for Th- 230 and 0,9 pCi/1 for Th- 228 , for 1000 minutes of counting time. (author)

8th International Workshop on Simulation

CERN Document Server

Rasch, Dieter; Melas, Viatcheslav; Moder, Karl; Statistics and simulation

2018-01-01

This volume features original contributions and invited review articles on mathematical statistics, statistical simulation and experimental design. The selected peer-reviewed contributions originate from the 8th International Workshop on Simulation held in Vienna in 2015. The book is intended for mathematical statisticians, Ph.D. students and statisticians working in medicine, engineering, pharmacy, psychology, agriculture and other related fields. The International Workshops on Simulation are devoted to statistical techniques in stochastic simulation, data collection, design of scientific experiments and studies representing broad areas of interest. The first 6 workshops took place in St. Petersburg, Russia, in 1994 – 2009 and the 7th workshop was held in Rimini, Italy, in 2013.

1{sup st} workshop proceedings of the collaborative project ''Crystalline rock retention processes'' (7th EC FP CP CROCK)

Energy Technology Data Exchange (ETDEWEB)

Rabung, Thomas; Molinero, Jorge; Garcia, David; Montoya, Vanessa (eds.)

2012-07-01

The EURATOM 7th EC Framework Program Collaborative Project Crystalline ROCK retention processes (CROCK) started in January 2011 and extends over 2 and a half years. The key driver for initiation the CP CROCK, identified by national Waste Management Organizations, is the undesired high uncertainty and the associated conservatism with respect to the radionuclide transport in the crystalline host-rock far-field around geological disposal of high-level radioactive wastes.

Region 7 Laboratory Information Management System

Data.gov (United States)

U.S. Environmental Protection Agency — This is metadata documentation for the Region 7 Laboratory Information Management System (R7LIMS) which maintains records for the Regional Laboratory. Any Laboratory...

Measurement of the neutron-induced fission cross section of 232Th relative to 235U from 0.7 to 30 MeV

International Nuclear Information System (INIS)

Behzens, T.W.; Ables, E.; Browne, T.C.

1982-01-01

The authors have measured the fission cross-section ratio 232 Th: 235 U as a function of neutron energy from 0.7 to 30 MeV using ionization fission chambers, the threshold cross-section method, and the time-of-flight technique at the Lawrence Livermore National Laboratory 100-MeV electron linear accelerator. The measured cross-section ratio, averaged over the neutron energy interval from 1.75 to 4.00 MeV, was 0.1086 + 0.0024

Blessing of dimensionality if forecasting house price growth rate in the 9 census divisions of the US: 7th Triennial Conference 2009

CSIR Research Space (South Africa)

Das, Sonali

2009-01-01

Full Text Available stream_source_info Das3_2009.pdf.txt stream_content_type text/plain stream_size 11099 Content-Encoding UTF-8 stream_name Das3_2009.pdf.txt Content-Type text/plain; charset=UTF-8 Motivation Models Data Results..., Pretoria 3University of Johannesburg, Johannesburg 7th Triennial, Kolkata, 2009 Das, Gupta and Kabundi Motivation Models Data Results Conclusion Main question Background Outline 1 Motivation 2 Models 3 Data 4 Results 5 Conclusion 2 / 24...

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line

International Nuclear Information System (INIS)

Zhang Danhui; Kanthasamy, Arthi; Anantharam, Vellareddy; Kanthasamy, Anumantha

2011-01-01

Manganese (Mn) exposure causes manganism, a neurological disorder similar to Parkinson's disease. However, the cellular mechanism by which Mn impairs the dopaminergic neurotransmitter system remains unclear. We previously demonstrated that caspase-3-dependent proteolytic activation of protein kinase C delta (PKCδ) plays a key role in Mn-induced apoptotic cell death in dopaminergic neurons. Recently, we showed that PKCδ negatively regulates tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, by enhancing protein phosphatase-2A activity in dopaminergic neurons. Here, we report that Mn exposure can affect the enzymatic activity of TH, the rate-limiting enzyme in dopamine synthesis, by activating PKCδ-PP2A signaling pathway in a dopaminergic cell model. Low dose Mn (3-10 μM) exposure to differentiated mesencephalic dopaminergic neuronal cells for 3 h induced a significant increase in TH activity and phosphorylation of TH-Ser40. The PKCδ specific inhibitor rottlerin did not prevent Mn-induced TH activity or TH-Ser40 phosphorylation. On the contrary, chronic exposure to 0.1-1 μM Mn for 24 h induced a dose-dependent decrease in TH activity. Interestingly, chronic Mn treatment significantly increased PKCδ kinase activity and protein phosphatase 2A (PP2A) enzyme activity. Treatment with the PKCδ inhibitor rottlerin almost completely prevented chronic Mn-induced reduction in TH activity, as well as increased PP2A activity. Neither acute nor chronic Mn exposures induced any cytotoxic cell death or altered TH protein levels. Collectively, these results demonstrate that low dose Mn exposure impairs TH activity in dopaminergic cells through activation of PKCδ and PP2A activity.

Th17 cells in neuromyelitis optica spectrum disorder: a review.

Science.gov (United States)

Lin, Jie; Li, Xiang; Xia, Junhui

2016-12-01

Neuromyelitis optica spectrum disorder (NMOSD) has been identified as a central nervous system (CNS) autoimmune inflammatory disorder, which has been recognized as a B cell-mediated humoral immune disease. However, cases have been reported indicating that some of the neuromyelitis optica (NMO) patients have been resistant to B cell-related treatments. Recently, more and more evidence has shown that T cell-mediated immunity may take part in the pathogenesis of NMOSD, especially in the Th17 phenotype. In our PUBMED search, we used the following keywords: Th17 cell, Th17 cell-related cytokines, T cells, B cells, B cell-related productions, NMO, NMOSD, recurrent/bilateral optic neuritis, recurrent transverse myelitis and longitudinally extensive transverse myelitis. We systemically reviewed the role of Th17 cells and Th17 cell-related cytokines in NMOSD. We found that Th17 cells and Th17-related cytokines, such as IL-6, IL-1β, IL-17, IL-21, IL-22, IL-23 and TGF-β, are not only directly involved in the pathogenesis but also collaborated with B cells and B cell-related antibody production to induce CNS lesions. Th17 cell-related therapy has also been reviewed in this article, and the data suggested that Th17 may be a new therapeutic target of NMOSD.

Use of Jigsaw Technique to Teach the Unit "Science within Time" in Secondary 7th Grade Social Sciences Course and Students' Views on This Technique

Science.gov (United States)

Yapici, Hakki

2016-01-01

The aim of this study is to apply the jigsaw technique in Social Sciences teaching and to unroll the effects of this technique on learning. The unit "Science within Time" in the secondary 7th grade Social Sciences text book was chosen for the research. It is aimed to compare the jigsaw technique with the traditional teaching method in…

Down-regulation of the Th1, Th17, and Th22 pathways due to anti-TNF-α treatment in psoriasis.

Science.gov (United States)

Luan, Li; Han, Shixin; Wang, Hua; Liu, Xiaoming

2015-12-01

Psoriasis is a T-cell-mediated chronic inflammatory dermatosis. Th1, Th17 and Th22 cells are suggested to contribute to the pathogenesis of psoriasis. To determine whether treatment with the anti-tumor-necrosis-factor antagonist, adalimumab, induces significant modulation of the Th1, Th17 and Th22 pathways, and correlates cellular activity with clinical response. This study included 21 patients with moderate-to-severe psoriasis who were treated with adalimumab, and 10 healthy control subjects. Blood samples were collected at baseline and at week 12. Flow cytometry was used to analyze the frequency of circulating Th1, Th17 and Th22 cells. Real-time polymerase chain reaction was used to analyze the expression of T-bet (Th1-related), retinoid-acid receptor-related orphan receptor gamma t (RORγt, Th17-related) and aryl hydrocarbon receptor (AHR, Th22-related). An enzyme-linked immunosorbent assay was used to analyze the serum levels of IFN-γ, IL-17, IL-22, IL-6 and tumor necrosis factor-α (TNF-α). At baseline, the frequencies of Th1, Th17 and Th22 cells were higher in psoriasis patients compared to the healthy controls. The expression of transcription factors T-bet, RORγt and AHR, and the serum levels of IFN-γ, IL-17, IL-22, IL-6 and TNF-α were higher in psoriasis patients compared to the healthy controls. After adalimumab therapy, there was a significant decline in the frequencies of Th1, Th17 and Th22 cells, and a concomitant decrease in the levels of their associated transcription factors and cytokines. The results suggest that the anti-tumor-necrosis-factor antagonist, adalimumab, disrupts the Th1, Th17 and Th22 pathways, resulting in clinical improvement of psoriasis. Copyright © 2015 Elsevier B.V. All rights reserved.

Th/U-233 multi-recycle in PWRs

International Nuclear Information System (INIS)

Yun, D.; Kim, T.K.; Taiwo, T.A.

2010-01-01

Th/U-233 multirecycle. Recent studies done internationally and in the U.S. are briefly summarized. Additionally, the previous U.S. thorium breeder experiment in the Shippingport reactor is briefly discussed. The objective of this work and the reactor design issues associated with multirecycle of Th/U-233 are discussed in Section 3. The approaches required to achieve a sustainable system are discussed and evaluated. Homogeneous assembly modeling results are presented in this section. In Section 4, a 17-by-17 heterogeneous assembly design has been selected and evaluated, based on its positive attributes for sustainable Th/U-233 multirecycle. A feasibility study is briefly discussed at the end of this section followed by recommendations for future activities. Section 5 discusses the attributes of the 17-by-17 heterogeneous assembly design. The material mass flow data and fuel cycle impact data are reported in this section. Discussions on the fuel cycle implications of thorium fuel utilization are provided in Section 6. This includes information on fuel sources, fuel manufacturing, fuel reprocessing, and re-fabrication. The conclusions of the study are provided in Section 7.

Th/U-233 multi-recycle in PWRs.

Energy Technology Data Exchange (ETDEWEB)

Yun, D.; Kim, T. K.; Taiwo, T. A.; Nuclear Engineering Division

2010-09-07

Th/U-233 multirecycle. Recent studies done internationally and in the U.S. are briefly summarized. Additionally, the previous U.S. thorium breeder experiment in the Shippingport reactor is briefly discussed. The objective of this work and the reactor design issues associated with multirecycle of Th/U-233 are discussed in Section 3. The approaches required to achieve a sustainable system are discussed and evaluated. Homogeneous assembly modeling results are presented in this section. In Section 4, a 17-by-17 heterogeneous assembly design has been selected and evaluated, based on its positive attributes for sustainable Th/U-233 multirecycle. A feasibility study is briefly discussed at the end of this section followed by recommendations for future activities. Section 5 discusses the attributes of the 17-by-17 heterogeneous assembly design. The material mass flow data and fuel cycle impact data are reported in this section. Discussions on the fuel cycle implications of thorium fuel utilization are provided in Section 6. This includes information on fuel sources, fuel manufacturing, fuel reprocessing, and re-fabrication. The conclusions of the study are provided in Section 7.

76 FR 34215 - Notice of Department of Energy-Quadrennial Technology Review Capstone Workshop

Science.gov (United States)

2011-06-13

... Council of Advisors on Science & Technology. This Administration's national energy goals are to: Reduce..., 2011)], the Department requested public comment on the questions related to the DOE-QTR and the framing... framing document: In the mobile sector, these are vehicle efficiency, electrification, and advanced fuels...

FY 1998 Report on development of technologies for commercialization of photovoltaic power systems. International co-operative project (IEA implementing agreement for a co-operative programme on photovoltaic power systems, 11th and 12th executive committee meetings); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu kokusai kyoryoku jigyo. IEA taiyoko hatsuden system kenkyu kyoryoku program jisshi kyotei dai 12 kai dai 11 kai shikko iinkai

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Described herein are outline of the International Energy Agency/Co-operative programme on Photovoltaic Power Systems (IEA/PVPS), and minutes of the 11th and 12th executive committee meetings. Japan signed the IEA Implementing Agreement for a co-operative programme on Photovoltaic Power Systems in April 1993, and has been participating in the programme for research and development, demonstration, analysis, information exchange and introduction promotion, among others. Presented to the 11th executive committee meeting are progresses in each task, review of the PVPS programme by an independent reviewer, strategy for the next term of the PVPS agreement, and marketing of PV in the IEA member countries. The meeting also has confirmed the action plans and partial responsibilities. In the 12th executive committee meeting, the progresses of the tasks, e.g., objects, activities and problems, are reported, and reviewed by the participants. Discussed in the task 1, information exchange, are new communication methods, publication frequency and contents of Internal Survey Report, and opening of the internet home page, among others. (NEDO)

Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes.

Science.gov (United States)

Arellano, Gabriel; Acuña, Eric; Reyes, Lilian I; Ottum, Payton A; De Sarno, Patrizia; Villarroel, Luis; Ciampi, Ethel; Uribe-San Martín, Reinaldo; Cárcamo, Claudia; Naves, Rodrigo

2017-01-01

Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. It is a heterogeneous pathology that can follow different clinical courses, and the mechanisms that underlie the progression of the immune response across MS subtypes remain incompletely understood. Here, we aimed to determine differences in the immunological status among different MS clinical subtypes. Blood samples from untreated patients diagnosed with clinically isolated syndrome (CIS) ( n  = 21), different clinical forms of MS ( n  = 62) [relapsing-remitting (RRMS), secondary progressive, and primary progressive], and healthy controls (HCs) ( n  = 17) were tested for plasma levels of interferon (IFN)-γ, IL-10, TGF-β, IL-17A, and IL-17F by immunoanalysis. Th1 and Th17 lymphocyte frequencies were determined by flow cytometry. Our results showed that IFN-γ levels and the IFN-γ/IL-10 ratio were higher in CIS patients than in RRMS patients and HC. Th1 cell frequencies were higher in CIS and RRMS than in progressive MS, and RRMS had a higher Th17 frequency than CIS. The Th1/Th17 cell ratio was skewed toward Th1 in CIS compared to MS phenotypes and HC. Receiver operating characteristic statistical analysis determined that IFN-γ, the IFN-γ/IL-10 ratio, Th1 cell frequency, and the Th1/Th17 cell ratio discriminated among CIS and MS subtypes. A subanalysis among patients expressing high IL-17F levels showed that IL-17F and the IFN-γ/IL-17F ratio discriminated between disease subtypes. Overall, our data showed that CIS and MS phenotypes displayed distinct Th1- and Th17-related cytokines and cell profiles and that these immune parameters discriminated between clinical forms. Upon validation, these parameters might be useful as biomarkers to predict disease progression.

Missionary Activity of the Russian Orthodox Church in Chukotka (17th - early 20th cc.

Directory of Open Access Journals (Sweden)

Yurganova Inna Igorevna

2015-06-01

Full Text Available We consider the missionary activity of the Russian Orthodox Church in the Chukotka Peninsula in the context of civilizational component integration into the Russian imperial areas in the 17th - early 20th centuries, including a brief historiography of the problem, the history of the construction of churches and chapels, the creation of the Orthodox mission, its structure and the territorial boundaries of the missionary activities. The author defines milestones for the Christianization of the Chukchi, introduces into science unpublished archival sources, assesses the activities of missionaries, determines the outcome of the spread of Orthodoxy in the beginning of the 20th century. It has been established that the state and church authorities, taking into consideration the difficulties of serving on the outskirts of the empire, developed a system of privileges and rewards for missionaries: increased salaries, payments ration and others, but missionary (marching service was difficult and dangerous. It is noted that despite the actual transfer of the Chukotka mission Aleutian diocese (headed by future Russian Patriarch Tikhon (Belavin in the beginning of the 20th century, statements of mission and purpose of the missionaries remained the prerogative of the Yakutian bishops. The study found that the spread of Orthodoxy in the Chukotka region in the 17th – early 20th centuries did not become a significant factor in the imperial policy on including the peninsula in the Russian state, which is associated with objective (harsh climate, a nomadic way of life of the population, lack of railways and subjective (long armed resistance, the small number of missionaries and the lack of material software, the lack of permanent control reasons. In order to achieve significant results Chukotka needed constant (regular missionary work, requiring both tangible investments (travel missionaries, food, labor, interpreters, creating living conditions for missionaries

The abandonment of the Hispano-Roman street plan: changes in the road network and sanitation infrastructure between 2nd and 7th centuries AD

Directory of Open Access Journals (Sweden)

Manuel D. Ruiz-Bueno

2018-06-01

Full Text Available The transformation of the classical civitas into the city of Late Antiquity was a long-term process within which saw a profound change in the traditional street plan. A critical analysis of the available sources, especially those of archaeological interest, has allowed us to study the evolution of both the Hispano-Roman street plan and the sanitation infrastructure between the 2nd & 7th centuries AD. The need to examine this process on a scale that exceeds the purely local geographical setting has led us to carry out a study where we have analysed different phenomena: the partial or total occupation of a number of porticos and roads; the replacement of stone pavements with earth, which also made the level of the road surface higher, and the slow but progressive neglect of the sewerage system. In contrast to the traditional view, we believe that the abandonment of the Hispano-Roman street plan was a process in which the authorities played a key role.

Chemical and structural evolution in the Th-SeO3(2-)/SeO4(2-) system: from simple selenites to cluster-based selenate compounds.

Science.gov (United States)

Xiao, Bin; Langer, Eike; Dellen, Jakob; Schlenz, Hartmut; Bosbach, Dirk; Suleimanov, Evgeny V; Alekseev, Evgeny V

2015-03-16

While extensive success has been gained in the structural chemistry of the U-Se system, the synthesis and characterization of Th-based Se structures are widely unexplored. Here, four new Th-Se compounds, α-Th(SeO3)2, β-Th(SeO3)2, Th(Se2O5)2, and Th3O2(OH)2(SeO4)3, have been obtained from mild hydrothermal or low-temperature (180-220 °C) flux conditions and were subsequently structurally and spectroscopically characterized. The crystal structures of α-Th(SeO3)2 and β-Th(SeO3)2 are based on ThO8 and SeO3 polyhedra, respectively, featuring a three-dimensional (3D) network with selenite anions filling in the Th channels along the a axis. Th(Se2O5)2 is a 3D framework composed of isolated ThO8 polyhedra interconnected by [Se2O5](2-) dimers. Th3O2(OH)2(SeO4)3 is also a 3D framework constructed by octahedral hexathorium clusters [Th6(μ3-O)4(μ3-OH)4](12+), which are interlinked by selenate groups SeO4(2-). The positions of the vibrational modes associated with both Se(IV)O3(2-) and Se(VI)O4(2-) units, respectively, were determined for four compounds, and the Raman spectra of α- and β-Th(SeO3)2 are compared and discussed in detail.

11th International Federation of Automatic Control (IFAC) Workshop on Time-Delay Systems

CERN Document Server

Fridman, Emilia; Sename, Olivier; Dugard, Luc

2016-01-01

This book mostly results from a selection of papers presented during the 11th IFAC (International Federation of Automatic Control) Workshop on Time-Delay Systems, which took place in Grenoble, France, February 4 - 6, 2013.  During this event, 37 papers were presented. Taking into account the reviewers' evaluation and the papers' presentation the best papers have been selected and collected into the present volume. The authors of 13 selected papers were invited to participate to this book and provided a more detailed and improved version of the conference paper. To enrich the book, three more chapters have been included from specialists on time-delay systems who presented their work during the 52nd IEEE Conference on Decision and Control, which held in December 10 - 13, 2013, at Florence, Italy. The content of the book is divided into four main parts as follows: Modeling, Stability analysis, Stabilization and control, and Input-delay systems. Focusing on various topics of time-delay systems, this book will be...

Electrodisintegration of 232Th by neutron emission

International Nuclear Information System (INIS)

Terremoto, L.A.A.

1986-01-01

The one neutron decay of the giant electric quadrupole resonance was studied by means of electrodisintegration and photodisintegration reactions. The separation of the multipole components of the photonuclear cross section σ γ,n (E) in 232 90 Th was also performed. The 232 Th(e,n) 231 Th cross section and the 232 Th(B,n) 231 Th bremsstrahlung yield were measured in the incident electron energy range 8-60 MeV and 25-60 MeV, respectively. These measurements have been performed using the electron beam of the Linear Accelerator of the IFUSP and the experimental technique of activation analysis. The virtual photon spectra corrected for nuclear finite size in the analysis of the experimental data obtained in order to separate the multipole components of the photonuclear cross section, was used. An electric dipole component σ EL γ,n (E) that exhausts (60+-7)% of the El sum rule (integrated uσ to 16,5 MeV) was shown. This result is in agreement with the one Obtained in experiments where monoenergetic photons were used. An electric quadrupole component σ E2 γ,n (E) whose value corresponds to (32+-6)% of the E2 sum rule, was also obtained. (author) [pt

W7-AS/W7-X contributions to the 19th European conference on controlled fusion and plasma heating (Innsbruck, June 29 to July 3, 1992). - W7-AS contributions to the 10th PSI conference (Monterey, USA, March 30 to April 3, 1992)

International Nuclear Information System (INIS)

1992-07-01

This paper contains 24 contributions with the following topics: Current drive and bootstrap current in stellators; Statistical analysis of luminescence signals obbserved during pellet injection; Density fluctuation measurements by broadband heterodyne reflectometry on the W7-AS stellarator; Measurements of electron cyclotron emission during high power ECRH in the W7-AS stellarator; Density, potential and temperature fluctuation in Wendelstein 7-AS; Measurement of coherent temperature fluctuation on the stellarator Wendelstein 7-AS (W7-AS); Localized impurity flux measurements on W7-AS; The optimum ion confinement mode in W7-A stellarator induced by fast ion orbit losses of the nearly perpendicular NBI; Electron heat transport in the LMFP-regime for the stellators W7-A, W7-AS and L2; Diffusive and connective transport modelling from analysis of ECRH-stimulated electron heat wave propagation; Modified vacuum fields and compensation of islands for the stellarator W7-AS; Towards higher β in the stellarator W7-AS; Influence of electric fields on the heating efficiency in the W7-AS stellarator; Mode activity at high plasma pressure in the stellarator W7-AS; Sniffer probe measurements in W7-AS; Local neutral particle density in the W7-AS stellarator; A general solution of the ripple-averaged kinetic equation (GSRAKE); Progress in the studies of URAGAN-2M stability and transport properties; Optimization of coils and sweep coil system for W-7-X; On stationary flow in the boundary region of toroidal system; Finite ion gyro radius stabilization of ideal MHD ballooning modes in optimized stellarators; Bulk-boronized operation in the W7-AS stellarator; The impact of boundary plasma conditions on the plasma performance; Transport study on the boundary plasma of the W7-AS. (orig./MM)

[Analysis of allele dropout at TH01 locus in paternity testing].

Science.gov (United States)

Lai, Li; Shen, Xiao-li; Xue, Shi-jie; Hu, Jie

2013-10-01

To analyze allele dropout at TH01 locus in paternity testing in order to determine the accurate genotype. To use a two STR loci genotyping system to verify an abnormal genotype for the TH01 locus with PCR using specific primers, cloning and DNA sequencing. A rare allele at TH01 locus named 5.2, which was undetectable with PowerPlex 21 system, was detected with an Identifiler system. Genetic variations may result in rare alleles and loci loss. To avoid misjudgment, laboratories should have a variety of methods for detecting loci loss.

Native American Students' Understanding of Geologic Time Scale: 4th-8th Grade Ojibwe Students' Understanding of Earth's Geologic History

Science.gov (United States)

Nam, Younkyeong; Karahan, Engin; Roehrig, Gillian

2016-01-01

Geologic time scale is a very important concept for understanding long-term earth system events such as climate change. This study examines forty-three 4th-8th grade Native American--particularly Ojibwe tribe--students' understanding of relative ordering and absolute time of Earth's significant geological and biological events. This study also…

Evolution of Th and U whole-rock contents in the Ilimaussaq intrusion

International Nuclear Information System (INIS)

Bailey, J.C.; Rose-Hansen, J.; Loevborg, L.; Soerensen, H.

1981-01-01

A great variety of investigations have been made on the distribution of Th and U in the Ilimaussaq alkaline, South Greenland. The major emphasis has been placed on economic assessment of the Kvanefjeld uranium deposit but attention has also been given to the Th and U contents of rocks and minerals outside the deposit. In the present study, we present Th and U values largely obtained by laboratory gamma-ray spectrometric (GRS) analysis of a large collection of representative samples taken from all rock types of the intrusion. The results are discussed in relation to current knowledge and ideas on the petrologic evolution of the Ilimaussaq intrusion. The behaviour of Th and U in igneous systems is moderately well known. During closed-system fractional crystallization, Th and U are generally excluded from the cumulus phases and attain higher levels in successive residual magmas. In most cumulate sequences, they are held in the trapped liquid (mesostasis). In both magmas and cumulates, the Th/U ratio remains virtually unchanged from the ratio of the parent magma. Only a few examples are known where significant amounts of Th-, U-rich cumulus phases (e.g. perovskite, eudialyte) crystallise and disturb the Th/U ratio. At many loctions, fractional crystallization occurred under open-system conditions and Th and U were redistributed by mobile fluids. These are frequently concentrated in roof zones or added to the surrounding country rocks. Elsewhere, post-magmatic Th-U metasomatism may be so intense that few of the primary, magmatic features are preserved. Previous invetigators of Th and U at Ilimaussaq have found evidence for closed- and open-system conditions at different stages of the evolution, and also for post-magmatic metasomatism. (author)

The 7th Workshop for PhD Students in Object-Oriented Systems

DEFF Research Database (Denmark)

1997-01-01

the communication and cooperation between them. In a year of the PhDOOS network the workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information on the PhDOOS network can be found at http://purl.org/net/PhDOOS.......It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving...

Development of automation and remotisation systems for fabrication of (Th-233U)O2 MOX fuel for AHWR

International Nuclear Information System (INIS)

Saraswat, Anupam; Danny, K.M.; Chakraborty, S.; Somayajulu, P.S.; Kumar, Arun; Mittal, R.; Prasad, R.S.; Mahule, K.N.; Panda, S.; Jayarajan, K.

2011-01-01

To meet the ever increasing power requirement of India, country is planning to utilize its large thorium reserves for the third stage of nuclear power program based on Thorium-Uranium 233 fuel in A.H.W.R. Although there are many advantages of (Th- 233 U)O 2 fuel cycle, presence of radiological hazards due to the presence of 1000-2000 ppm level of 232 U in the 233 U fuel and inertness of ThO 2 makes handling and fabrication of fuel difficult. The associated high alpha and gamma activity demands high level of automation and remote handling in alpha tight hot cells. To demonstrate automation and remotisation in (Th- 233 U)O 2 fuel fabrication, a mock up facility is being set up at BARC. This facility shall develop automation systems required for remote fuel fabrication in a simulated hot cell environment. There are many innovative schemes and systems being developed like integrated powder pellet system, remote viewing system for hot cell application etc. Low visibility inside the hot cell has always been a problem for the operator. To overcome this problem a remote viewing system has been developed by which entire hot cell area can be scanned with the use of a joystick and the display can be seen on a LCD monitor. The viewing system is made up of radiation resistant optics which can work even in high gamma fields. It consists of objective end assembly which is used to scan the hot cell area with the help of prism doublets and drive mechanism for capturing full 360 deg solid angle view. There is a Galilean telescope and focusing system used for focusing images of distant objects. Drive mechanism can be controlled by the joystick available to the operator. System has a high resolution CCD display and camera which gives a clear display of objects lying inside the hot cell area. Integrated powder pellet system is being developed for fabrication of MOX pellets from feed powder. This will be automated system which will take input in the form of MOX powder and convert it

Th1 and Th2 help for B cells

DEFF Research Database (Denmark)

Poudrier, J; Owens, T

1995-01-01

that IL-5 (125 U/ml) synergizes with Th1 cells to induce B cell responses to IL-2, that are maintained following T-cell removal, e.g. autonomous. Th1 help in the absence of IL-5 resulted in weak or undetectable responses following T cell removal. The mechanism of IL-5 synergy involved persistence of IL-2R...... anti-Ig did not circumvent the need for IL-5 for autonomous IL-2 responses. Consistent with the above, interaction with an IL-5-producing Th2 clone induced strong autonomous B cell responses to IL-2. Qualitative differences of Th2 help over that of Th1 may thus be attributable to their differential...

Contributions to nonlinear elliptic equations and systems a tribute to Djairo Guedes de Figueiredo on the occasion of his 80th birthday

CERN Document Server

Ruf, Bernhard; Santos, Ederson; Gossez, Jean-Pierre; Soares, Sergio; Cazenave, Thierry

2015-01-01

This volume of contributions pays tribute to the life and work of Djairo Guedes de Figueiredo on the occasion of his 80th birthday. The articles it contains were born out of the ICMC Summer Meeting on Differential Equations – 2014 Chapter, also dedicated to de Figueiredo and held at the Universidade de São Paulo at São Carlos, Brazil from February 3-7, 2014. The contributing authors represent a group of international experts in the field and discuss recent trends and new directions in nonlinear elliptic partial differential equations and systems. Djairo Guedes de Figueiredo has had a very active scientific career, publishing 29 monographs and over one hundred research articles. His influence on Brazilian mathematics has made him one of the pillars of the subject in that country. He had a major impact on the development of analysis, especially in its application to nonlinear elliptic partial differential equations and systems throughout the entire world. The articles collected here pay tribute to him and h...

19th Polish Control Conference

CERN Document Server

Kacprzyk, Janusz; Oprzędkiewicz, Krzysztof; Skruch, Paweł

2017-01-01

This volume contains the proceedings of the KKA 2017 – the 19th Polish Control Conference, organized by the Department of Automatics and Biomedical Engineering, AGH University of Science and Technology in Kraków, Poland on June 18–21, 2017, under the auspices of the Committee on Automatic Control and Robotics of the Polish Academy of Sciences, and the Commission for Engineering Sciences of the Polish Academy of Arts and Sciences. Part 1 deals with general issues of modeling and control, notably flow modeling and control, sliding mode, predictive, dual, etc. control. In turn, Part 2 focuses on optimization, estimation and prediction for control. Part 3 is concerned with autonomous vehicles, while Part 4 addresses applications. Part 5 discusses computer methods in control, and Part 6 examines fractional order calculus in the modeling and control of dynamic systems. Part 7 focuses on modern robotics. Part 8 deals with modeling and identification, while Part 9 deals with problems related to security, fault ...

Measuring Listening Comprehension Skills of 5th Grade School Students with the Help of Web Based System

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M. Bahaddin Acat

2016-01-01

Full Text Available The main purpose of this study is to measure listening comprehension skills of 5th grade school students with the help of web based system. This study was conducted on 5th grade students studying at the primary schools of Eskisehir. The scale used in the process of the study is “Web Based Listening Scale”. In the process of the study, it was investigated that the level of differentiation listening skill and educational level of mother and father, family income level, Turkish Course grading note, the most popular and listened music genre. According to the results obtained that significant difference was found with listening skills and educational level of mother and father, family income level and the most popular and listened music genre. Also it was found that there is powerful relationship between listening skills and Turkish Course grading note. In the process of the research, it was observed the students used the web based system more attentive and motivated. Nevertheless, personalized measuring environment was provided by the web based system. Finally, it can be said that the web based systems can be used positively for language learning, teaching, and instruction, improving, measuring and assessing process.

The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.

Science.gov (United States)

Li, Xia; Wang, Bin; Li, Yuzhu; Wang, Li; Zhao, Xiangzhong; Zhou, Xianbin; Guo, Yuqi; Jiang, Guosheng; Yao, Chengfang

2013-01-09

The Th1/Th2/Th17/Treg paradigm plays an important role in achieving maternal-fetal immunotolerance and participates in RU486-induced abortion. Excessive uterine bleeding is the most common side effect of RU486-induced abortion; however, its etiopathogenesis has not been fully understood. Therefore, elucidating the correlation between the Th1/Th2/Th17/Treg paradigm and the volume of uterine bleeding may offer novel therapeutic target for reducing uterine bleeding in RU486-induced abortion. Leonurus sibiricus has been used in clinics to reduce postpartum hemorrhage with low toxicity and high efficiency; however, the effective constituents and therapeutic mechanism have not been described. Stachydrine hydrochloride is the main constituent of L. sibiricus, therefore L. sibiricus is regarded as a candidate for reducing uterine bleeding in RU486-induced abortion mice by regulating the Th1/Th2/Th17/Treg paradigm. The purpose of this study was to determine the Th1/Th2/Th17/Treg paradigm in uterine bleeding of RU486-induced abortion mice and to elucidate the immunopharmacologic effects of stachydrine hydrochloride on inducing the Th1/Th2/Th17/Treg paradigm in reducing the uterine bleeding volume in RU486-induced abortion mice. To investigate the Th1/Th2/Th17/Treg paradigm in uterine bleeding during RU486-induced abortion mice, pregnant BALB/c mice were treated with high- and low-dose RU486 (1.5mg/kg and 0.9 mg/kg, respectively), and the serum progesterone (P(4)) protein level, uterine bleeding volume, and proportions of Th1/Th2/Th17/Treg cells in mice at the maternal-fetal interface were detected by ELISA assay, alkaline hematin photometric assay, and flow cytometry, respectively. To determine the regulatory effect of stachydrine hydrochloride on the Th1/Th2/Th17/Treg paradigm in vitro, splenocytes of non-pregnant mice were separated and treated with P(4,) RU486, and/or stachydrine hydrochloride (10(-5)M, 10(-4)M, and 10(-3)M, respectively). The proportions of Th1/Th2/Th17

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis.

Science.gov (United States)

Suárez-Fariñas, Mayte; Dhingra, Nikhil; Gittler, Julia; Shemer, Avner; Cardinale, Irma; de Guzman Strong, Cristina; Krueger, James G; Guttman-Yassky, Emma

2013-08-01

Atopic dermatitis (AD) is classified as extrinsic and intrinsic, representing approximately 80% and 20% of patients with the disease, respectively. Although sharing a similar clinical phenotype, only extrinsic AD is characterized by high serum IgE levels. Because most patients with AD exhibit high IgE levels, an "allergic"/IgE-mediated disease pathogenesis was hypothesized. However, current models associate AD with T-cell activation, particularly TH2/TH22 polarization, and epidermal barrier defects. We sought to define whether both variants share a common pathogenesis. We stratified 51 patients with severe AD into extrinsic AD (n = 42) and intrinsic AD (n = 9) groups (with similar mean disease activity/SCORAD scores) and analyzed the molecular and cellular skin pathology of lesional and nonlesional intrinsic AD and extrinsic AD by using gene expression (real-time PCR) and immunohistochemistry. A significant correlation between IgE levels and SCORAD scores (r = 0.76, P extrinsic AD. Marked infiltrates of T cells and dendritic cells and corresponding epidermal alterations (keratin 16, Mki67, and S100A7/A8/A9) defined lesional skin of patients with both variants. However, higher activation of all inflammatory axes (including TH2) was detected in patients with intrinsic AD, particularly TH17 and TH22 cytokines. Positive correlations between TH17-related molecules and SCORAD scores were only found in patients with intrinsic AD, whereas only patients with extrinsic AD showed positive correlations between SCORAD scores and TH2 cytokine (IL-4 and IL-5) levels and negative correlations with differentiation products (loricrin and periplakin). Although differences in TH17 and TH22 activation exist between patients with intrinsic AD and those with extrinsic AD, we identified common disease-defining features of T-cell activation, production of polarized cytokines, and keratinocyte responses to immune products. Our data indicate that a TH2 bias is not the sole cause of high Ig

The effect of antenatal steroids on fetal lung maturation between the 34th and 36th week of pregnancy.

Science.gov (United States)

Balci, Osman; Ozdemir, Suna; Mahmoud, Alaa S; Acar, Ali; Colakoglu, Mehmet C

2010-01-01

To evaluate the effect of antenatal treatment with a single dose of betamethasone between the 34th and the 36th week of pregnancy on the maturation of fetal lung. To study 100 pregnant women in their 34th-36th week of pregnancy who were diagnosed as susceptible to have preterm delivery. Fifty patients did not receive betamethasone (group 1). The other 50 patients were administered 12 mg betamethasone in a single dose (group 2). Patients who delivered at least 24 h after the administration of betamethasone were included in this study. After delivery, the Apgar score and the development of respiratory distress syndrome (RDS) in the neonates were compared. Group 2 babies had better Apgar scores when compared to group 1, and the difference was statistically significant. Sixteen (32%) neonates of group 1 and 7 (14%) neonates of group 2 required resuscitation, and the difference was statistically significant (p = 0.032; OR = 0.34, 95% CI 0.12-0.93). RDS was detected in 8 newborns of group 1 and 2 of group 2. The difference was statistically significant (p = 0.046; OR = 0.21, 95% CI 0.04-1.08). The administration of a single dose of betamethasone to pregnant women in their 34th-36th week of pregnancy who are likely to have preterm delivery reduces RDS development. There is a need for larger studies to confirm these results. Copyright 2010 S. Karger AG, Basel.

Research priorities for the health sector for the 8th Malaysia Plan

International Nuclear Information System (INIS)

Narimah Awin

2000-01-01

At the inter-institutional meeting to identify, the research priorities for the sector for the 7MP (7 th Malaysian Plan), held in mid-1994, priorities were determined according to the hierarchy of socioeconomic groups, target areas, programmes and scopes. The more detailed projects under these were to be determined by the researchers they embark on the projects themselves. The most useful level for reference is the target area. There were 7 target areas identified at the deliberations, and an eighth one (medical biotechnology) was added later on by the IRPA Secretariat in the Ministry of Science Technology and Environment. These 8 target areas are: 1)Health problems associated with lifestyles 2) Health problems related to demographic changes, 3) Vector borne and other communicable diseases, 4 ) Epidemiological databases, 5) Technologies in health, 6)The health system and health care industry, 7) Environmental and occupational health, 8) Medical biotechnology. (author)

What Were the Causes of the Delay of the 79th Division Capturing Montfaucon during the Meuse-Argonne Offensive in World War I?

Science.gov (United States)

2011-06-10

7Leonard P. Ayres, The War with Germany: A Statistical Summary (Washington, DC: Government Printing Office, 1919), 21. 8Historical board of the...by looking at this statistic alone, the effectiveness of the primary weapon system of the 79th Division was somewhere around 33 percent. Outside of...those gigantic tanks we had heard so much about.‖178 Fortunately for the men of the 79th, their lack of training in combined arms operations with armor

Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.

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Xing, Zhi-Zhi; Huang, Liu-Ye; Wu, Cheng-Rong; You, Hong; Ma, Hong; Jia, Ji-Dong

2015-06-21

To investigate the effects of activated rat hepatic stellate cells (HSCs) on rat Th1/Th2 profile in vitro. Growth and survival of activated HSCs and CD4(+) T lymphocytes cultured alone or together was assessed after 24 or 48 h. CD4(+) T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon (IFN)-γ(+)] and Th2 [interleukin (IL)-4(+)] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from CD4(+) T lymphocytes that were positive for CD25 but did not express IFN-γ or IL-4 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated HSCs. Co-culture of CD4(+) T lymphocytes with activated rat HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions (-1.73% ± 0.71%; P Th1/Th2 ratio was significantly decreased (-0.44 ± 0.13; P Th1 cells was decreased (-65.71 ± 9.67; P Th1 (12.27% ± 0.99%; P Th1 cell apoptosis rate was significantly higher than in Th2 cells (P Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells (1.85% ± 0.48%; P Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis.

[Study on the correlation of the effect of entecavir on Th1/Th2 cytokines level in the treatment of chronic hepatitis].

Science.gov (United States)

Li, L; Jing, Y B; Liu, J; Wang, C L; Liu, B

2017-08-20

Objective: To explore the expression level of peripheral blood Th1/Th2 type cytokines of chronic hepatitis b (CHB) patients in the entecavir (ETV) antiviral treatment, analyze the relationship between various cytokines, and the correlation among of cytokines and HBV DNA loads. Methods: Luminex Liquid Chip Technology was applied to detect the peripheral blood Th1/Th2 type cytokines expression level of CHB patients; At the same time, liver function was detected by Fully Automatic Biochemical Analyzer; HBV DNA loads were detected by PCR Method; Hepatitis b virology markers were detected by Chemiluminescence Method. F-test and Pearson correlation analysis were used for statistical analysis. Results: Before ETV antiviral treatment, peripheral blood Th1 cytokines IFN gamma expression level in patients with CHB increased significantly ( P = 0.010) compared with the healthy control group while TNF alpha expression level having no statistically significant difference ( P = 0.095); Th2 type cytokines IL-4, IL-6, IL-10 levels decreased obviously ( P = 0.039, P = 0.014, P = 0.026) compared with those in the control group. After 48 weeks of treatment, Th1 cytokines IFN gamma and TNF alpha expression levels were reduced significantly (19.2±5.03 pg/ml vs 24.69±6.51 pg/ml, and 6.09±4.99 pg/ml vs 9.50±7.34 pg/ml, P Th1/Th2 type cytokines. And there was no correlation between the various cytokines and HBV DNA loads in patients with CHB. Conclusion: ETV can not only inhibit HBV DNA replication, reducing HBV DNA loads, but also contribute to regulate Th1/Th2 type cytokines expression level in patients with CHB, but there was no correlation between the levels of various cytokines, various cytokines and HBV DNA loads.