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Sample records for sv diffeomorphisms concentrated

  1. Diffeomorphism Spline

    Directory of Open Access Journals (Sweden)

    Wei Zeng

    2015-04-01

    Full Text Available Conventional splines offer powerful means for modeling surfaces and volumes in three-dimensional Euclidean space. A one-dimensional quaternion spline has been applied for animation purpose, where the splines are defined to model a one-dimensional submanifold in the three-dimensional Lie group. Given two surfaces, all of the diffeomorphisms between them form an infinite dimensional manifold, the so-called diffeomorphism space. In this work, we propose a novel scheme to model finite dimensional submanifolds in the diffeomorphism space by generalizing conventional splines. According to quasiconformal geometry theorem, each diffeomorphism determines a Beltrami differential on the source surface. Inversely, the diffeomorphism is determined by its Beltrami differential with normalization conditions. Therefore, the diffeomorphism space has one-to-one correspondence to the space of a special differential form. The convex combination of Beltrami differentials is still a Beltrami differential. Therefore, the conventional spline scheme can be generalized to the Beltrami differential space and, consequently, to the diffeomorphism space. Our experiments demonstrate the efficiency and efficacy of diffeomorphism splines. The diffeomorphism spline has many potential applications, such as surface registration, tracking and animation.

  2. The Invisibility of Diffeomorphisms

    Science.gov (United States)

    De Haro, Sebastian

    2017-10-01

    I examine the relationship between (d+1) -dimensional Poincaré metrics and d-dimensional conformal manifolds, from both mathematical and physical perspectives. The results have a bearing on several conceptual issues relating to asymptotic symmetries in general relativity and in gauge-gravity duality, as follows: (1: Ambient Construction) I draw from the remarkable work by Fefferman and Graham (Elie Cartan et les Mathématiques d'aujourd'hui, Astérisque, 1985; The Ambient Metric. Annals of Mathematics Studies, Princeton University Press, Princeton, 2012) on conformal geometry, in order to prove two propositions and a theorem that characterise which classes of diffeomorphisms qualify as gravity-invisible. I define natural notions of gravity-invisibility (strong, weak, and simpliciter) that apply to the diffeomorphisms of Poincaré metrics in any dimension. (2: Dualities) I apply the notions of invisibility, developed in (1), to gauge-gravity dualities: which, roughly, relate Poincaré metrics in d+1 dimensions to QFTs in d dimensions. I contrast QFT-visible versus QFT-invisible diffeomorphisms: those gravity diffeomorphisms that can, respectively cannot, be seen from the QFT. The QFT-invisible diffeomorphisms are the ones which are relevant to the hole argument in Einstein spaces. The results on dualities are surprising, because the class of QFT-visible diffeomorphisms is larger than expected, and the class of QFT-invisible ones is smaller than expected, or usually believed, i.e. larger than the PBH diffeomorphisms in Imbimbo et al. (Class Quantum Gravity 17(5):1129, 2000, Eq. 2.6). I also give a general derivation of the asymptotic conformal Killing equation, which has not appeared in the literature before.

  3. The Invisibility of Diffeomorphisms

    Science.gov (United States)

    De Haro, Sebastian

    2017-11-01

    I examine the relationship between (d+1)-dimensional Poincaré metrics and d-dimensional conformal manifolds, from both mathematical and physical perspectives. The results have a bearing on several conceptual issues relating to asymptotic symmetries in general relativity and in gauge-gravity duality, as follows: (1: Ambient Construction) I draw from the remarkable work by Fefferman and Graham (Elie Cartan et les Mathématiques d'aujourd'hui, Astérisque, 1985; The Ambient Metric. Annals of Mathematics Studies, Princeton University Press, Princeton, 2012) on conformal geometry, in order to prove two propositions and a theorem that characterise which classes of diffeomorphisms qualify as gravity-invisible. I define natural notions of gravity-invisibility (strong, weak, and simpliciter) that apply to the diffeomorphisms of Poincaré metrics in any dimension. (2: Dualities) I apply the notions of invisibility, developed in (1), to gauge-gravity dualities: which, roughly, relate Poincaré metrics in d+1 dimensions to QFTs in d dimensions. I contrast QFT-visible versus QFT-invisible diffeomorphisms: those gravity diffeomorphisms that can, respectively cannot, be seen from the QFT. The QFT-invisible diffeomorphisms are the ones which are relevant to the hole argument in Einstein spaces. The results on dualities are surprising, because the class of QFT-visible diffeomorphisms is larger than expected, and the class of QFT-invisible ones is smaller than expected, or usually believed, i.e. larger than the PBH diffeomorphisms in Imbimbo et al. (Class Quantum Gravity 17(5):1129, 2000, Eq. 2.6). I also give a general derivation of the asymptotic conformal Killing equation, which has not appeared in the literature before.

  4. Diffeomorphic Statistical Deformation Models

    DEFF Research Database (Denmark)

    Hansen, Michael Sass; Hansen, Mads/Fogtman; Larsen, Rasmus

    2007-01-01

    In this paper we present a new method for constructing diffeomorphic statistical deformation models in arbitrary dimensional images with a nonlinear generative model and a linear parameter space. Our deformation model is a modified version of the diffeomorphic model introduced by Cootes et al....... The modifications ensure that no boundary restriction has to be enforced on the parameter space to prevent folds or tears in the deformation field. For straightforward statistical analysis, principal component analysis and sparse methods, we assume that the parameters for a class of deformations lie on a linear...... manifold and that the distance between two deformations are given by the metric introduced by the L2-norm in the parameter space. The chosen L2-norm is shown to have a clear and intuitive interpretation on the usual nonlinear manifold. Our model is validated on a set of MR images of corpus callosum...

  5. Homological stability of diffeomorphism groups

    DEFF Research Database (Denmark)

    Berglund, Alexander; Madsen, Ib Henning

    2013-01-01

    In this paper we prove a stability theorem for block diffeomorphisms of 2d -dimensional manifolds that are connected sums of S d ×S d . Combining this with a recent theorem of S. Galatius and O. Randal-Williams and Morlet’s lemma of disjunction, we determine the homology of the classifying space ...

  6. Diffeomorphisms of elliptic 3-manifolds

    CERN Document Server

    Hong, Sungbok; McCullough, Darryl; Rubinstein, J Hyam

    2012-01-01

    This work concerns the diffeomorphism groups of 3-manifolds, in particular of elliptic 3-manifolds. These are the closed 3-manifolds that admit a Riemannian metric of constant positive curvature, now known to be exactly the closed 3-manifolds that have a finite fundamental group. The (Generalized) Smale Conjecture asserts that for any elliptic 3-manifold M, the inclusion from the isometry group of M to its diffeomorphism group is a homotopy equivalence. The original Smale Conjecture, for the 3-sphere, was proven by J. Cerf and A. Hatcher, and N. Ivanov proved the generalized conjecture for many of the elliptic 3-manifolds that contain a geometrically incompressible Klein bottle. The main results establish the Smale Conjecture for all elliptic 3-manifolds containing geometrically incompressible Klein bottles, and for all lens spaces L(m,q) with m at least 3. Additional results imply that for a Haken Seifert-fibered 3 manifold V, the space of Seifert fiberings has contractible components, and apart from a small...

  7. Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1.

    Science.gov (United States)

    Chu, Yuening; Wang, Yi; Zheng, Zhihuang; Lin, Yuli; He, Rui; Liu, Jun; Yang, Xuguang

    2017-01-01

    Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD) using a glucose-based dialysate. Mesothelial cells (MCs) take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1) and interleukin 8 (IL-8). The apoptosis of MCs induced by high glucose levels also contributes to complications of PD. High mobility group protein B1 (HMGB1) is an inflammatory factor that has repeatedly been proven to be related to the occurrence of peritoneal dysfunction. Aim: In this study, we aimed to explore the effect and underlying mechanism of endogenous HMGB1 in high-glucose-induced MC injury. Methods: The human peritoneal MC line, HMrSV5 was cultured in high-glucose medium and incubated with recombinant HMGB1. Cellular expression of HMGB1 was blocked using HMGB1 small interfering RNA (siRNA). Apoptosis and production of inflammatory factors as well as the potential intermediary signaling pathways were examined. Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. In conclusion, endogenous HMGB1 plays an important role in the inflammatory reaction induced by high glucose on MCs via mitogen-activated protein kinase (MAPK) signaling pathways, but it seems to have little effect on high-glucose-induced apoptosis.

  8. Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1

    Directory of Open Access Journals (Sweden)

    Yuening Chu

    2017-09-01

    Full Text Available Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD using a glucose-based dialysate. Mesothelial cells (MCs take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1 and interleukin 8 (IL-8. The apoptosis of MCs induced by high glucose levels also contributes to complications of PD. High mobility group protein B1 (HMGB1 is an inflammatory factor that has repeatedly been proven to be related to the occurrence of peritoneal dysfunction.Aim: In this study, we aimed to explore the effect and underlying mechanism of endogenous HMGB1 in high-glucose-induced MC injury.Methods: The human peritoneal MC line, HMrSV5 was cultured in high-glucose medium and incubated with recombinant HMGB1. Cellular expression of HMGB1 was blocked using HMGB1 small interfering RNA (siRNA. Apoptosis and production of inflammatory factors as well as the potential intermediary signaling pathways were examined.Results: The major findings of these analyses were: (1 MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2 HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3 HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. In conclusion, endogenous HMGB1 plays an important role in the inflammatory reaction induced by high glucose on MCs via mitogen-activated protein kinase (MAPK signaling pathways, but it seems to have little effect on high-glucose-induced apoptosis.

  9. Effective field theory of broken spatial diffeomorphisms

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Chunshan [Yukawa Institute for Theoretical Physics, Kyoto University,Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI),The University of Tokyo Institutes for Advanced Study, The University of Tokyo,Kashiwa, Chiba 277-8583 (Japan); Labun, Lance Z. [Department of Physics, University of Texas,2515 Speedway, MS #C1510, Austin, TX 78712-1068 (United States); Department of Physics, National Taiwan University,No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China); Leung Center for Cosmology and Particle Astrophysics (LeCosPA), National Taiwan University,No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China)

    2016-03-17

    We study the low energy effective theory describing gravity with broken spatial diffeomorphism invariance. In the unitary gauge, the Goldstone bosons associated with broken diffeomorphisms are eaten and the graviton becomes a massive spin-2 particle with 5 well-behaved degrees of freedom. In this gauge, the most general theory is built with the lowest dimension operators invariant under only temporal diffeomorphisms. Imposing the additional shift and SO(3) internal symmetries, we analyze the perturbations on a FRW background. At linear perturbation level, the observables of this theory are characterized by five parameters, including the usual cosmological parameters and one additional coupling constant for the symmetry-breaking scalars. In the de Sitter and Minkowski limit, the three Goldstone bosons are supermassive and can be integrated out, leaving two massive tensor modes as the only propagating degrees of freedom. We discuss several examples relevant to theories of massive gravity.

  10. Circle diffeomorphisms forced by expanding circle maps

    NARCIS (Netherlands)

    Homburg, A.J.

    2012-01-01

    We discuss the dynamics of skew product maps defined by circle diffeomorphisms forced by expanding circle maps. We construct an open class of such systems that are robustly topologically mixing and for which almost all points in the same fiber converge under iteration. This property follows from the

  11. Periodic diffeomorphisms on homotopy E(4) surfaces

    Indian Academy of Sciences (India)

    In [9], there is an open problem proposed by Allan Edmonds: Question 1.1. Do K3 surfaces admit a periodic diffeomorphism of prime order acting trivially on cohomology (or homology)?. This question was motivated by the corresponding rigidity for holomorphic actions [1]. It was shown to be true for topological ones [4] and ...

  12. The embedding flows of C hyperbolic diffeomorphisms

    Science.gov (United States)

    Zhang, Xiang

    2011-03-01

    In [Weigu Li, J. Llibre, Xiang Zhang, Extension of Floquet's theory to nonlinear periodic differential systems and embedding diffeomorphisms in differential flows, Amer. J. Math. 124 (2002) 107-127] we proved that for a germ of C hyperbolic diffeomorphisms F(x)=Ax+f(x) in (R,0), if A has a real logarithm with its eigenvalues weakly nonresonant, then F(x) can be embedded in a C autonomous differential system. Its proof was very complicated, which involved the existence of embedding periodic vector field of F(x) and the extension of the Floquet's theory to nonlinear C periodic differential systems. In this paper we shall provide a simple and direct proof to this last result. Next we shall show that the weakly nonresonant condition in the last result on the real logarithm of A is necessary for some C diffeomorphisms F(x)=Ax+f(x) to have C embedding flows. Finally we shall prove that a germ of C hyperbolic diffeomorphisms F(x)=Ax+f(x) with f(x)=O(|) in (R,0) has a C embedding flow if and only if either A has no negative eigenvalues or A has two equal negative eigenvalues and it can be diagonalizable.

  13. Simvastatin (SV) metabolites in mouse tissues

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, C.A.; Vickers, S. (Merck Sharp and Dohme Research Labs., West Point, PA (United States))

    1990-02-26

    SV, a semisynthetic analog of lovastatin, is hydrolyzed in vivo to its hydroxy acid (SVA), a potent inhibitor of HMG CoA reductase (HR). Thus SV lowers plasma cholesterol. SV is a substrate for mixed function oxidases whereas SVA undergoes lactonization and {beta}-oxidation. Male CD-1 mice were dosed orally with a combination of ({sup 14}C)SV and ({sup 3}H)SVA at 25 mg/kg of each, bled and killed at 0.5, 2 and 4 hours. Labeled SV, SVA, 6{prime}exomethylene SV (I), 6{prime}CH{sub 2}OH-SV (II), 6{prime}COOH-SV (III) and a {beta}-oxidized metabolite (IV) were assayed in liver, bile, kidneys, testes and plasma by RIDA. Levels of potential and active HR inhibitors in liver were 10 to 40 fold higher than in other tissues. II and III, in which the configuration at 6{prime} is inverted, may be 2 metabolites of I. Metabolites I-III are inhibitors of HR in their hydroxy acid forms. Qualitatively ({sup 14}C)SV and ({sup 3}H)SVA were metabolized similarly (consistent with their proposed interconversion). However {sup 3}H-SVA, I-III (including hydroxy acid forms) achieved higher concentrations than corresponding {sup 14}C compounds (except in gall bladder bile). Major radioactive metabolites in liver were II-IV (including hydroxy acid forms). These metabolites have also been reported in rat tissues. In bile a large fraction of either label was unidentified polar metabolites. The presence of IV indicated that mice (like rats) are not good models for SV metabolism in man.

  14. Collocation for diffeomorphic deformations in medical image registration

    DEFF Research Database (Denmark)

    Darkner, Sune; Pai, Akshay Sadananda Uppinakudru; Liptrot, Matthew George

    2018-01-01

    Diffeomorphic deformation is a popular choice in medical image registration. A fundamental property of diffeomorphisms is in vertibility, implying that once the relation between two points A to B is found, then the relation B to A is given per definition. Consistency is a measure of a numerical...

  15. Uniqueness of SRB measures for transitive diffeomorphisms on surfaces

    OpenAIRE

    Hertz, F. Rodriguez; Hertz, M. A. Rodriguez; Tahzibi, A.; Ures, R.

    2010-01-01

    We give a description of ergodic components of SRB measures in terms of ergodic homoclinic classes associated to hyperbolic periodic points. For transitive surface diffeomorphisms, we prove that there exists at most one SRB measure.

  16. A new formulation of non-relativistic diffeomorphism invariance

    CERN Document Server

    Banerjee, Rabin; Mukherjee, Pradip

    2014-01-01

    We provide a new formulation of nonrelativistic diffeomorphism invariance. It is generated by localising the usual global Galilean Symmetry. The correspondence with the type of diffeomorphism invariant models currently in vogue in the theory of fractional quantum Hall effect has been discussed. Our construction is shown to open up a general approach of model building in theoretical condensed matter physics. Also, this formulation has the capacity of obtaining Newton - Cartan geometry from the gauge procedure.

  17. A new formulation of non-relativistic diffeomorphism invariance

    Directory of Open Access Journals (Sweden)

    Rabin Banerjee

    2014-10-01

    Full Text Available We provide a new formulation of non-relativistic diffeomorphism invariance. It is generated by localising the usual global Galilean symmetry. The correspondence with the type of diffeomorphism invariant models currently in vogue in the theory of fractional quantum Hall effect has been discussed. Our construction is shown to open up a general approach of model building in theoretical condensed matter physics. Also, this formulation has the capacity of obtaining Newton–Cartan geometry from the gauge procedure.

  18. A new formulation of non-relativistic diffeomorphism invariance

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, Rabin, E-mail: rabin@bose.res.in [S.N. Bose National Centre for Basic Sciences, JD Block, Sector III, Salt Lake City, Kolkata-700 098 (India); Mitra, Arpita, E-mail: arpita12t@bose.res.in [S.N. Bose National Centre for Basic Sciences, JD Block, Sector III, Salt Lake City, Kolkata-700 098 (India); Mukherjee, Pradip, E-mail: mukhpradip@gmail.com [Department of Physics, Barasat Government College, Barasat, West Bengal (India)

    2014-10-07

    We provide a new formulation of non-relativistic diffeomorphism invariance. It is generated by localising the usual global Galilean symmetry. The correspondence with the type of diffeomorphism invariant models currently in vogue in the theory of fractional quantum Hall effect has been discussed. Our construction is shown to open up a general approach of model building in theoretical condensed matter physics. Also, this formulation has the capacity of obtaining Newton–Cartan geometry from the gauge procedure.

  19. Robust Diffeomorphic Mapping via Geodesically Controlled Active Shapes

    Directory of Open Access Journals (Sweden)

    Daniel J. Tward

    2013-01-01

    Full Text Available This paper presents recent advances in the use of diffeomorphic active shapes which incorporate the conservation laws of large deformation diffeomorphic metric mapping. The equations of evolution satisfying the conservation law are geodesics under the diffeomorphism metric and therefore termed geodesically controlled diffeomorphic active shapes (GDAS. Our principal application in this paper is on robust diffeomorphic mapping methods based on parameterized surface representations of subcortical template structures. Our parametrization of the GDAS evolution is via the initial momentum representation in the tangent space of the template surface. The dimension of this representation is constrained using principal component analysis generated from training samples. In this work, we seek to use template surfaces to generate segmentations of the hippocampus with three data attachment terms: surface matching, landmark matching, and inside-outside modeling from grayscale T1 MR imaging data. This is formulated as an energy minimization problem, where energy describes shape variability and data attachment accuracy, and we derive a variational solution. A gradient descent strategy is employed in the numerical optimization. For the landmark matching case, we demonstrate the robustness of this algorithm as applied to the workflow of a large neuroanatomical study by comparing to an existing diffeomorphic landmark matching algorithm.

  20. Generic Diffeomorphisms with Superexponential Growth of Number of Periodic Orbits

    Science.gov (United States)

    Kaloshin, Vadim Yu.

    Let M be a smooth compact manifold of dimension at least 2 and Diffr(M) be the space of Cr smooth diffeomorphisms of M. Associate to each diffeomorphism f;isin; Diffr(M) the sequence Pn(f) of the number of isolated periodic points for f of period n. In this paper we exhibit an open set N in the space of diffeomorphisms Diffr(M) such for a Baire generic diffeomorphism f∈N the number of periodic points Pnf grows with a period n faster than any following sequence of numbers {an}n∈Z+ along a subsequence, i.e. Pn(f)>ani for some ni-->∞ with i-->∞. In the cases of surface diffeomorphisms, i.e. dim M≡2, an open set N with a supergrowth of the number of periodic points is a Newhouse domain. A proof of the man result is based on the Gontchenko-Shilnikov-Turaev Theorem [GST]. A complete proof of that theorem is also presented.

  1. Large deformation diffeomorphic metric mapping of orientation distribution functions.

    Science.gov (United States)

    Du, Jia; Goh, Alvina; Qiu, Anqi

    2011-01-01

    We propose a novel large deformation diffeomorphic registration algorithm to align high angular resolution diffusion images (HARDI) characterized by Orientation Distribution Functions (ODF). Our proposed algorithm seeks an optimal diffeomorphism of large deformation between two ODF fields in a spatial volume domain and at the same time, locally reorients an ODF in a manner such that it remains consistent with the surrounding anatomical structure. We first extend ODFs traditionally defined in a unit sphere to a generalized ODF defined in R3. This makes it easy for an affine transformation as well as a diffeomorphic group action to be applied on the ODF. We then construct a Riemannian space of the generalized ODFs and incorporate its Riemannian metric for the similarity of ODFs into a variational problem defined under the large deformation diffeomorphic metric mapping (LDDMM) framework. We finally derive the gradient of the cost function in both Riemannian spaces of diffeomorphisms and the generalized ODFs, and present its numerical implementation. Both synthetic and real brain HARDI data are used to illustrate the performance of our registration algorithm.

  2. Diffeomorphic image registration with automatic time-step adjustment

    DEFF Research Database (Denmark)

    Pai, Akshay Sadananda Uppinakudru; Klein, S.; Sommer, Stefan Horst

    2015-01-01

    In this paper, we propose an automated Euler's time-step adjustment scheme for diffeomorphic image registration using stationary velocity fields (SVFs). The proposed variational problem aims at bounding the inverse consistency error by adaptively adjusting the number of Euler's step required...

  3. Diffeomorphism invariant cosmological sector in loop quantum gravity

    Science.gov (United States)

    Beetle, C.; Engle, J. S.; Hogan, M. E.; Mendonça, P.

    2017-11-01

    In this paper we work out in detail a new proposal to define rigorously a sector of loop quantum gravity at the diffeomorphism invariant level corresponding to homogeneous and isotropic cosmologies, and propose how to compare in detail the physics of this sector with that of loop quantum cosmology. The key technical steps we have completed are (a) to formulate conditions for homogeneity and isotropy in a diffeomorphism covariant way on the classical phase space of general relativity, and (b) to translate these conditions consistently using well-understood techniques to loop quantum gravity. To impose the symmetry at the quantum level, on both the connection and its conjugate momentum, the method used necessarily has similiarities to the Gupta-Bleuler method of quantizing the electromagnetic field. Lastly, a strategy for embedding states of loop quantum cosmology into this new homogeneous isotropic sector, and using this embedding to compare the physics, is presented.

  4. Frame to Frame Diffeomorphic Motion Analysis from Echocardiographic Sequences

    OpenAIRE

    Zhang, Zhijun; Sahn, David; Song, Xubo

    2011-01-01

    International audience; Quantitative motion analysis from echocardiography is an important yet challenging problem. We develop a motion estimation algorithm for echocardiographic image sequences based on diffeomorphic image registration in which the velocity field is spatiotemporally smooth. The novelty of this work is that instead of optimizing a functional of velocity field which consists of similarity metrics between a reference image to each of the following images (\\textitfirst-to-follow...

  5. Space-Time Diffeomorphisms in Noncommutative Gauge Theories

    Directory of Open Access Journals (Sweden)

    L. Román Juarez

    2008-07-01

    Full Text Available In previous work [Rosenbaum M. et al., J. Phys. A: Math. Theor. 40 (2007, 10367–10382] we have shown how for canonical parametrized field theories, where space-time is placed on the same footing as the other fields in the theory, the representation of space-time diffeomorphisms provides a very convenient scheme for analyzing the induced twisted deformation of these diffeomorphisms, as a result of the space-time noncommutativity. However, for gauge field theories (and of course also for canonical geometrodynamics where the Poisson brackets of the constraints explicitely depend on the embedding variables, this Poisson algebra cannot be connected directly with a representation of the complete Lie algebra of space-time diffeomorphisms, because not all the field variables turn out to have a dynamical character [Isham C.J., Kuchar K.V., Ann. Physics 164 (1985, 288–315, 316–333]. Nonetheless, such an homomorphic mapping can be recuperated by first modifying the original action and then adding additional constraints in the formalism in order to retrieve the original theory, as shown by Kuchar and Stone for the case of the parametrized Maxwell field in [Kuchar K.V., Stone S.L., Classical Quantum Gravity 4 (1987, 319–328]. Making use of a combination of all of these ideas, we are therefore able to apply our canonical reparametrization approach in order to derive the deformed Lie algebra of the noncommutative space-time diffeomorphisms as well as to consider how gauge transformations act on the twisted algebras of gauge and particle fields. Thus, hopefully, adding clarification on some outstanding issues in the literature concerning the symmetries for gauge theories in noncommutative space-times.

  6. Explicit B-spline regularization in diffeomorphic image registration.

    Science.gov (United States)

    Tustison, Nicholas J; Avants, Brian B

    2013-01-01

    Diffeomorphic mappings are central to image registration due largely to their topological properties and success in providing biologically plausible solutions to deformation and morphological estimation problems. Popular diffeomorphic image registration algorithms include those characterized by time-varying and constant velocity fields, and symmetrical considerations. Prior information in the form of regularization is used to enforce transform plausibility taking the form of physics-based constraints or through some approximation thereof, e.g., Gaussian smoothing of the vector fields [a la Thirion's Demons (Thirion, 1998)]. In the context of the original Demons' framework, the so-called directly manipulated free-form deformation (DMFFD) (Tustison et al., 2009) can be viewed as a smoothing alternative in which explicit regularization is achieved through fast B-spline approximation. This characterization can be used to provide B-spline "flavored" diffeomorphic image registration solutions with several advantages. Implementation is open source and available through the Insight Toolkit and our Advanced Normalization Tools (ANTs) repository. A thorough comparative evaluation with the well-known SyN algorithm (Avants et al., 2008), implemented within the same framework, and its B-spline analog is performed using open labeled brain data and open source evaluation tools.

  7. Oltar sv. Wolfganga u Vukovoju

    OpenAIRE

    Repanić Braun, Mirjana; Škarić, Ksenija; Wolff Zubović, Martina; Cavalli Ladašić, Helena

    2013-01-01

    Od 2004. do 2010. godine u Hrvatskom restauratorskom zavodu restauriran je oltar sv. Wolfganga iz kapele u Vukovoju, jedinstveni primjer bogato kićenog manirističkog oltara iz sredine 17. stoljeća u kontinentalnoj Hrvatskoj koji je u neznatno preinačenom stanju sačuvan na izvornom mjestu. Oltar se tradicionalno datira u 1650. godinu, zahvaljujući natpisu ispod slike s drugoga kata. Konzervatorsko-restauratorska istraživanja pokazala su da taj natpis ne pripada polikromiji 17. stoljeća, već je...

  8. A Livšic type theorem for germs of analytic diffeomorphisms

    Science.gov (United States)

    Navas, Andrés; Ponce, Mario

    2013-01-01

    We deal with the problem of the validity of the Livšic theorem for cocycles of diffeomorphisms over a hyperbolic dynamics that satisfy the periodic orbit condition. We give a result in the positive direction for cocycles of germs of analytic diffeomorphisms at the origin.

  9. Diffeomorphic registration using geodesic shooting and Gauss–Newton optimisation

    Science.gov (United States)

    Ashburner, John; Friston, Karl J.

    2011-01-01

    This paper presents a nonlinear image registration algorithm based on the setting of Large Deformation Diffeomorphic Metric Mapping (LDDMM), but with a more efficient optimisation scheme — both in terms of memory required and the number of iterations required to reach convergence. Rather than perform a variational optimisation on a series of velocity fields, the algorithm is formulated to use a geodesic shooting procedure, so that only an initial velocity is estimated. A Gauss–Newton optimisation strategy is used to achieve faster convergence. The algorithm was evaluated using freely available manually labelled datasets, and found to compare favourably with other inter-subject registration algorithms evaluated using the same data. PMID:21216294

  10. Archaeomagnetic SV curve for Belgium

    Science.gov (United States)

    Ech-chakrouni, Souad; Hus, Jozef

    2017-04-01

    Archaeomagnetic secular variation curves have been established for different countries in Europe, especially when different archeological sites are more or less uniformly distributed in time are available. The disadvantage in that case is that data had to be relocated to a single reference site. The proximity of the reference locality Paris to Belgium makes that we used the French archaeomagnetic SV curve for the last three millennia up to the present for archaeomagnetic dating undated baked structures. In total, 85 baked structures have been examined, unearthed in 24 archaeological sites of the territory of Belgium. The ChRM of each sample was obtained by principal component analysis for at least three demagnetisation steps (Kirschvink 1980). Except for some outliers, the ChRM directions are very coherent with a high confidence factor (α95Belgium with Uccle as reference locality, where the first measurement of the geomagnetic field was done in 1895. This curve would include all the available reference data in a radius of about 500 km around Uccle. Keywords: secular variation, archaeomagnetic dating, Belgium.

  11. Examples of Minimal Diffeomorphisms on $t^{2}$ Semiconjugated to an Ergodic Translation

    OpenAIRE

    Passeggi, Alejandro; Sambarino, Martin

    2010-01-01

    We prove that for every $\\epsilon>0$ there exists a minimal diffeomorphism $f:\\T^{2}\\rightarrow\\T^{2}$ of class $C^{3-\\epsilon}$ and semiconjugate to an ergodic traslation, and have the following properties: zero entropy, sensitivity with respect to initial conditions and Li-Yorke chaos. These examples are obtained through the holonomy of the unstable foliation of Ma\\~{n}\\'e's example of derived from Anosov diffeomorphism on $\\T^3.$

  12. Primal-dual convex optimization in large deformation diffeomorphic metric mapping: LDDMM meets robust regularizers

    Science.gov (United States)

    Hernandez, Monica

    2017-12-01

    This paper proposes a method for primal-dual convex optimization in variational large deformation diffeomorphic metric mapping problems formulated with robust regularizers and robust image similarity metrics. The method is based on Chambolle and Pock primal-dual algorithm for solving general convex optimization problems. Diagonal preconditioning is used to ensure the convergence of the algorithm to the global minimum. We consider three robust regularizers liable to provide acceptable results in diffeomorphic registration: Huber, V-Huber and total generalized variation. The Huber norm is used in the image similarity term. The primal-dual equations are derived for the stationary and the non-stationary parameterizations of diffeomorphisms. The resulting algorithms have been implemented for running in the GPU using Cuda. For the most memory consuming methods, we have developed a multi-GPU implementation. The GPU implementations allowed us to perform an exhaustive evaluation study in NIREP and LPBA40 databases. The experiments showed that, for all the considered regularizers, the proposed method converges to diffeomorphic solutions while better preserving discontinuities at the boundaries of the objects compared to baseline diffeomorphic registration methods. In most cases, the evaluation showed a competitive performance for the robust regularizers, close to the performance of the baseline diffeomorphic registration methods.

  13. Large deformation diffeomorphic registration of diffusion-weighted imaging data.

    Science.gov (United States)

    Zhang, Pei; Niethammer, Marc; Shen, Dinggang; Yap, Pew-Thian

    2014-12-01

    Registration plays an important role in group analysis of diffusion-weighted imaging (DWI) data. It can be used to build a reference anatomy for investigating structural variation or tracking changes in white matter. Unlike traditional scalar image registration where spatial alignment is the only focus, registration of DWI data requires both spatial alignment of structures and reorientation of local signal profiles. As such, DWI registration is much more complex and challenging than scalar image registration. Although a variety of algorithms has been proposed to tackle the problem, most of them are restricted by the diffusion model used for registration, making it difficult to fit to the registered data a different model. In this paper we describe a method that allows any diffusion model to be fitted after registration for subsequent multifaceted analysis. This is achieved by directly aligning DWI data using a large deformation diffeomorphic registration framework. Our algorithm seeks the optimal coordinate mapping by simultaneously considering structural alignment, local signal profile reorientation, and deformation regularization. Our algorithm also incorporates a multi-kernel strategy to concurrently register anatomical structures at different scales. We demonstrate the efficacy of our approach using in vivo data and report detailed qualitative and quantitative results in comparison with several different registration strategies. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Non-stationary diffeomorphic registration: application to endo-vascular treatment monitoring

    Science.gov (United States)

    De Craene, M.; Camara, O.; Bijnens, B.; Frangi, A. F.

    2009-02-01

    This paper proposes a new pairwise registration algorithm called Large Diffeomorphic Free-Form Deformation (LDFFD). In the LDFFD algorithm, the diffeomorphic mapping is represented as a composition of Free-Form Deformation (FFD) transformations at each time step, all time steps being jointly optimized. The fact that the transformation at one time step influences all subsequent time steps, naturally enforces temporal consistency in the transformation compared to other existing diffeomorphic registration algorithms and does not restrict the space of solutions to stationary displacement fields over all time steps. A multiresolution strategy is presented to find the optimal number of time steps and solve efficiently the joint optimization of all transformations in the registration chain. Accuracy of the algorithm in the presence of large deformations is illustrated and compared to other standard or diffeomorphic registration algorithms. Our algorithm is applied here in the context of monitoring disease progression by image-based quantification of aneurysmal growth post endovascular treatment. In this context, aneurysm volume changes occurring after embolization are quantified by integrating the Jacobian of the diffeomorphic transformation between 3D rotational angiography images acquired at subsequent followups.

  15. Columnar structure of SV40 minichromosome

    Directory of Open Access Journals (Sweden)

    Edward N Trifonov

    2015-07-01

    Full Text Available Like the sequence of the strongest 601 clone nucleosome of Lowary and Widom, the SV40 genome sequence contains tracks of YR dinucleotides separated by small integers of the 10.4n base series (10, 11, 21 and 30 bases. The tracks, however, substantially exceed the nucleosome DNA size and, thus, correspond to more extended structure - columnar chromatin. The micrococcal nuclease digests of the SV40 chromatin do not show uniquely positioned individual nucleosomes. This confirms the columnar structure of the minichromosome, as well as earlier electron microscopy studies.

  16. Black hole entropy in the Chern–Simons-like theories of gravity and Lorentz-diffeomorphism Noether charge

    Directory of Open Access Journals (Sweden)

    M.R. Setare

    2016-01-01

    Full Text Available In the first order formalism of gravity theories, there are some theories which are not Lorentz-diffeomorphism covariant. In the framework of such theories we cannot apply the method of conserved charge calculation used in Lorentz-diffeomorphism covariant theories. In this paper we firstly introduce the total variation of a quantity due to an infinitesimal Lorentz-diffeomorphism transformation. Secondly, in order to obtain the conserved charges of Lorentz-diffeomorphism non-covariant theories, we extend the Tachikawa method [1]. This extension includes not only Lorentz gauge transformation but also the diffeomorphism. We apply this method to the Chern–Simons-like theories of gravity (CSLTG and obtain a general formula for the entropy of black holes in those theories. Finally, some examples on CSLTG are provided and the entropy of the BTZ black hole is calculated in the context of the examples.

  17. Black hole entropy in the Chern–Simons-like theories of gravity and Lorentz-diffeomorphism Noether charge

    Energy Technology Data Exchange (ETDEWEB)

    Setare, M.R., E-mail: rezakord@ipm.ir; Adami, H., E-mail: hamed.adami@yahoo.com

    2016-01-15

    In the first order formalism of gravity theories, there are some theories which are not Lorentz-diffeomorphism covariant. In the framework of such theories we cannot apply the method of conserved charge calculation used in Lorentz-diffeomorphism covariant theories. In this paper we firstly introduce the total variation of a quantity due to an infinitesimal Lorentz-diffeomorphism transformation. Secondly, in order to obtain the conserved charges of Lorentz-diffeomorphism non-covariant theories, we extend the Tachikawa method [1]. This extension includes not only Lorentz gauge transformation but also the diffeomorphism. We apply this method to the Chern–Simons-like theories of gravity (CSLTG) and obtain a general formula for the entropy of black holes in those theories. Finally, some examples on CSLTG are provided and the entropy of the BTZ black hole is calculated in the context of the examples.

  18. Locally Linear Diffeomorphic Metric Embedding (LLDME) for surface-based anatomical shape modeling.

    Science.gov (United States)

    Yang, Xianfeng; Goh, Alvina; Qiu, Anqi

    2011-05-01

    This paper presents the algorithm, Locally Linear Diffeomorphic Metric Embedding (LLDME), for constructing efficient and compact representations of surface-based brain shapes whose variations are characterized using Large Deformation Diffeomorphic Metric Mapping (LDDMM). Our hypothesis is that the shape variations in the infinite-dimensional diffeomorphic metric space can be captured by a low-dimensional space. To do so, traditional Locally Linear Embedding (LLE) that reconstructs a data point from its neighbors in Euclidean space is extended to LLDME that requires interpolating a shape from its neighbors in the infinite-dimensional diffeomorphic metric space. This is made possible through the conservation law of momentum derived from LDDMM. It indicates that initial momentum, a linear transformation of the initial velocity of diffeomorphic flows, at a fixed template shape determines the geodesic connecting the template to a subject's shape in the diffeomorphic metric space and becomes the shape signature of an individual subject. This leads to the compact linear representation of the nonlinear diffeomorphisms in terms of the initial momentum. Since the initial momentum is in a linear space, a shape can be approximated by a linear combination of its neighbors in the diffeomorphic metric space. In addition, we provide efficient computations for the metric distance between two shapes through the first order approximation of the geodesic using the initial momentum as well as for the reconstruction of a shape given its low-dimensional Euclidean coordinates using the geodesic shooting with the initial momentum as the initial condition. Experiments are performed on the hippocampal shapes of 302 normal subjects across the whole life span (18-94years). Compared with Principal Component Analysis and ISOMAP, LLDME provides the most compact and efficient representation of the age-related hippocampal shapes. Even though the hippocampal volumes among young adults are as

  19. Novootkriveni autograf Filipa de Diversija iz 1455. godine: poslanice sv. Jeronima, sv. Augustina i drugih

    OpenAIRE

    Janeković-Römer, Zdenka

    2010-01-01

    Novotkriveni autograf Filipa de Diversi, kodeks u koji je prepisivao poslanice Sv. Jeronima, Sv. Augustina i drugih, donosi važne nove biografske i bibliografske podatke o njemu. Saznajemo da je 1455. godine još bio živ i boravio u Veneciji. Obiman kodeks (278 folija) sačuvan je u knjižnici earla od Leicestera, Holkham Hall u Engleskoj. Članak donosi popis svih poslanica prepisanih u kodeks, s bibliografskim podacima.

  20. Polynomial Normal Forms for Some Germs of Nonstrongly 1-Resonant Diffeomorphisms

    Science.gov (United States)

    Guo, Lingling; Ren, Zhihua

    2015-12-01

    We study in this paper a class of smoothly finite determined germs of diffeomorphisms which have infinitely many resonant relations near a nonstrongly 1-resonant fixed point on ℝ3 and derive the simplest normal forms of such germs with nondegenerated nonlinear parts.

  1. SV40 Assembly In Vivo and In Vitro

    Directory of Open Access Journals (Sweden)

    Ariella Oppenheim

    2008-01-01

    Full Text Available The Simian virus 40 (SV40 capsid is a T = 7d icosahedral lattice ∼45 nm in diameter surrounding the ∼5 kb circular minichromosome. The outer shell is composed of 360 monomers of the major capsid protein VP1, tightly bound in 72 pentamers. VP1 is a jellyroll β-barrel, with extending N- and C-terminal arms. The N-terminal arms bind DNA and face the interior of the capsid. The flexible C-arms tie together the 72 pentamers in three distinct kinds of interactions, thus facilitating the formation of a T = 7 icosahedron from identical pentameric building blocks. Assembly in vivo was shown to occur by addition of capsomers around the DNA. We apply a combination of biochemical and genetic approaches to study SV40 assembly. Our in vivo and in vitro studies suggest the following model: one or two capsomers bind at a high affinity to ses, the viral DNA encapsidation signal, forming the nucleation centre for assembly. Next, multiple capsomers attach concomitantly, at lower affinity, around the minichromosome. This increases their local concentration facilitating rapid, cooperative assembly reaction. Formation of the icosahedron proceeds either by gradual addition of single pentamers to the growing shell or by concerted assembly of pentamer clusters.

  2. New phases of D ge 2 current and diffeomorphism algebras in particle physics

    Energy Technology Data Exchange (ETDEWEB)

    Tze, Chia-Hsiung.

    1990-09-01

    We survey some global results and open issues of current algebras and their canonical field theoretical realization in D {ge} 2 dimensional spacetime. We assess the status of the representation theory of their generalized Kac-Moody and diffeomorphism algebras. Particular emphasis is put on higher dimensional analogs of fermi-bose correspondence, complex analyticity and the phase entanglements of anyonic solitons with exotic spin and statistics. 101 refs.

  3. Diffeomorphic metric mapping of high angular resolution diffusion imaging based on Riemannian structure of orientation distribution functions.

    Science.gov (United States)

    Du, Jia; Goh, Alvina; Qiu, Anqi

    2012-05-01

    In this paper, we propose a novel large deformation diffeomorphic registration algorithm to align high angular resolution diffusion images (HARDI) characterized by orientation distribution functions (ODFs). Our proposed algorithm seeks an optimal diffeomorphism of large deformation between two ODF fields in a spatial volume domain and at the same time, locally reorients an ODF in a manner such that it remains consistent with the surrounding anatomical structure. To this end, we first review the Riemannian manifold of ODFs. We then define the reorientation of an ODF when an affine transformation is applied and subsequently, define the diffeomorphic group action to be applied on the ODF based on this reorientation. We incorporate the Riemannian metric of ODFs for quantifying the similarity of two HARDI images into a variational problem defined under the large deformation diffeomorphic metric mapping framework. We finally derive the gradient of the cost function in both Riemannian spaces of diffeomorphisms and the ODFs, and present its numerical implementation. Both synthetic and real brain HARDI data are used to illustrate the performance of our registration algorithm.

  4. The moduli space of germs of generic families of analytic diffeomorphisms unfolding of a codimension one resonant diffeomorphism or resonant saddle

    Science.gov (United States)

    Rousseau, Christiane

    In this paper we describe the moduli space of germs of generic analytic families of complex 1-dimensional resonant analytic diffeomorphisms of codimension 1. In Rousseau and Christopher (2007) [11], it was shown that the Ecalle modulus can be unfolded to give a complete modulus for such germs. As function of the canonical parameter, the modulus is defined on two sectors giving a covering of a neighborhood of the origin in the parameter space. As in the case of the Ecalle modulus, the modulus is defined up to a linear scaling depending only on the parameter. The compatibility condition is obtained by considering the region of intersection of the two sectors in parameter space, which we call the Glutsyuk sectors. There, both the fixed point and the periodic orbit are hyperbolic and they are connected by the orbits of the diffeomorphism. This yields an alternate description of the equivalence class by the Glutsyuk modulus: near each of the fixed point and of the periodic orbit we construct a change of coordinate to the normal form. The Glutsyuk modulus measures the obstruction of having one being the analytic extension of the other. In the intersection of the two sectors, we have two representatives of the modulus which describe the same dynamics. A necessary compatibility condition is that they have the same Glutsyuk modulus. This necessary condition becomes sufficient for realizability. The compatibility condition implies the existence of a linear scaling for which the modulus is 1-summable in ɛ, whose directions of non-summability coincide with the direction of real multipliers at the fixed point and periodic orbit. Conversely, we show that the compatibility condition (which implies the summability property) is sufficient to realize the modulus as coming from an analytic unfolding, thus giving a complete description of the space of moduli.

  5. On the question of symmetries in nonrelativistic diffeomorphism-invariant theories

    Science.gov (United States)

    Banerjee, Rabin; Gangopadhyay, Sunandan; Mukherjee, Pradip

    2017-07-01

    A novel algorithm is provided to couple a Galilean-invariant model with curved spatial background by taking nonrelativistic limit of a unique minimally coupled relativistic theory, which ensures Galilean symmetry in the flat limit and canonical transformation of the original fields. That the twin requirements are fulfilled is ensured by a new field, the existence of which was demonstrated recently from Galilean gauge theory. The ambiguities and anomalies concerning the recovery of Galilean symmetry in the flat limit of spatial nonrelativistic diffeomorphic theories, reported in the literature, are focused and resolved from a new angle.

  6. THE IMPACT OF MATCHING FUNCTIONAL ON ATROPHY MEASUREMENT FROM GEODESIC SHOOTING IN DIFFEOMORPHISMS.

    Science.gov (United States)

    Fleishman, Greg M; Thompson, Paul M

    2017-01-01

    Longitudinal registration has been used to map brain atrophy and tissue loss patterns over time, in both healthy and demented subjects. However, we have not seen a thorough application of the geodesic shooting in diffeomorphisms framework for this task. The registration model is complex and several choices must be made that may significantly impact the quality of results. One of these decisions is which image matching functional should drive the registration. We investigate four matching functionals for atrophy quantification using geodesic shooting in diffeomorphisms. We check if the choice of matching functional has an impact on the correlation of atrophy scores with clinical variables. We also check the impact of matching functional choice on estimates of the N80 sample size for hypothetical clinical trials that test for slowing of brain atrophy. We find that the mutual information function, which has primarily been used for linear and multi-modal registration, achieves comparable correlation with clinical variables to other matching functionals while yielding better sample size estimates.

  7. Gauss-Newton inspired preconditioned optimization in large deformation diffeomorphic metric mapping.

    Science.gov (United States)

    Hernandez, Monica

    2014-10-21

    In this work, we propose a novel preconditioned optimization method in the paradigm of Large Deformation Diffeomorphic Metric Mapping (LDDMM). The preconditioned update scheme is formulated for the non-stationary and the stationary parameterizations of diffeomorphisms, yielding three different LDDMM methods. The preconditioning matrices are inspired in the Hessian approximation used in Gauss-Newton method. The derivatives are computed using Frechet differentials. Thus, optimization is performed in a Sobolev space, in contrast to optimization in L(2) commonly used in non-rigid registration literature. The proposed LDDMM methods have been evaluated and compared with their respective implementations of gradient descent optimization. Evaluation has been performed using real and simulated images from the Non-rigid Image Registration Evaluation Project (NIREP). The experiments conducted in this work reported that our preconditioned LDDMM methods achieved a performance similar or superior to well-established-in-literature gradient descent non-stationary LDDMM in the great majority of cases. Moreover, preconditioned optimization showed a substantial reduction in the execution time with an affordable increase of the memory usage per iteration. Additional experiments reported that optimization using Frechet differentials should be preferable to optimization using L(2) differentials.

  8. Reduction by Lie Group Symmetries in Diffeomorphic Image Registration and Deformation Modelling

    Directory of Open Access Journals (Sweden)

    Stefan Sommer

    2015-05-01

    Full Text Available We survey the role of reduction by symmetry in the large deformation diffeomorphic metric mapping framework for registration of a variety of data types (landmarks, curves, surfaces, images and higher-order derivative data. Particle relabelling symmetry allows the equations of motion to be reduced to the Lie algebra allowing the equations to be written purely in terms of the Eulerian velocity field. As a second use of symmetry, the infinite dimensional problem of finding correspondences between objects can be reduced for a range of concrete data types, resulting in compact representations of shape and spatial structure. Using reduction by symmetry, we describe these models in a common theoretical framework that draws on links between the registration problem and geometric mechanics. We outline these constructions and further cases where reduction by symmetry promises new approaches to the registration of complex data types.

  9. Strings from reduced large- N gauge theory via area preserving diffeomorphisms

    Science.gov (United States)

    Bars, Itzhak

    1990-08-01

    We map reduced large- N theories to a string formalism by using area preserving diffeomorphisms as a substitute for SU (∞). We suggest that there may be a limiting procedure, that involves a correlation between the limits of N and a cutoff parameter, in which the path integral of the reduced QCD model produces a sum over all Riemann surfaces in the form of an effective string theory. In particular large- N QCD becomes related to a string theory with the usual action, but with the world sheet metric gauge fixed to det ( γ)=-1 and a path integral measure different than the standard one. The measure could be changed to define a new large- N matrix path integral that is more faithful to string theory.

  10. The Fuzzy analogy of chiral diffeomorphisms in higher dimensional quantum field theories

    Energy Technology Data Exchange (ETDEWEB)

    Fassarella, Lucio; Schroer, Bert [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)]. E-mail: fassarel@cbpf.br; schroer@cbpf.br

    2001-06-01

    Our observation that the chiral diffeomorphisms allow an interpretation as modular groups of local operator algebras in the sense of Tomita and takesaki allows us to conclude that the higher deimensional generalizations are certain infinite dimensional groups which act in a 'fuzzy' way on the operator algebras of local quantum physics. These actions do not require any spacetime noncommutativity and are in complete harmony with causality and localization principles. The use of an appropriately defined isomorphism reprocesses these fuzzy actions into partially geometric actions on the holographic image and in this way tightens the relation with chiral structures and makes recent attempts to explain the required universal structure of a would be quantum Bekenstein law in terms of Virasoro algebra structures more palatable. (author)

  11. High-precision registration between zebrafish brain atlases using symmetric diffeomorphic normalization

    Science.gov (United States)

    Marquart, Gregory D.; Tabor, Kathryn M.; Horstick, Eric J.; Brown, Mary; Geoca, Alexandra K.; Polys, Nicholas F.; Nogare, Damian Dalle

    2017-01-01

    Abstract Atlases provide a framework for spatially mapping information from diverse sources into a common reference space. Specifically, brain atlases allow annotation of gene expression, cell morphology, connectivity, and activity. In larval zebrafish, advances in genetics, imaging, and computational methods now allow the collection of such information brain-wide. However, due to technical considerations, disparate datasets may use different references and may not be aligned to the same coordinate space. Two recent larval zebrafish atlases exemplify this problem: Z-Brain, containing gene expression, neural activity, and neuroanatomical segmentations, was acquired using immunohistochemical stains, while the Zebrafish Brain Browser (ZBB) was constructed from live scans of fluorescent reporters in transgenic larvae. Although different references were used, the atlases included several common transgenic patterns that provide potential “bridges” for transforming each into the other's coordinate space. We tested multiple bridging channels and registration algorithms and found that the symmetric diffeomorphic normalization algorithm improved live brain registration precision while better preserving cell morphology than B-spline-based registrations. Symmetric diffeomorphic normalization also corrected for tissue distortion introduced during fixation. Multi-reference channel optimization provided a transformation that enabled Z-Brain and ZBB to be co-aligned with precision of approximately a single cell diameter and minimal perturbation of cell and tissue morphology. Finally, we developed software to visualize brain regions in 3 dimensions, including a virtual reality neuroanatomy explorer. This study demonstrates the feasibility of integrating whole brain datasets, despite disparate reference templates and acquisition protocols, when sufficient information is present for bridging. Increased accuracy and interoperability of zebrafish digital brain atlases will

  12. Transgenic Mouse Models of SV40-Induced Cancer.

    Science.gov (United States)

    Hudson, Amanda L; Colvin, Emily K

    2016-01-01

    The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evolution of many mouse models of cancer. Despite the development of more modern and targeted approaches for developing genetically engineered mouse models of cancer, SV40-induced mouse models still remain frequently used today. This review discusses a number of cancer types in which SV40 mouse models of cancer have been developed and highlights their relevance and importance to preclinical research. © The Author 2016. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Cyclic variations of the period and luminosity of SV Camelopardalis

    Science.gov (United States)

    Manzoori, D.

    2016-06-01

    New standardized V-band light curves (LCs) for the eclipsing binary SV Cam have been modeled using the PHOEBE program (v. 0.31a). Absolute parameters of the stellar components were then determined, enabling them to be positioned on the mass-radius diagram. Analysis of eclipse minima timing data (O-C diagrams) indicated two cyclic periods of 48.0 and 23.3 yr. These cyclic variations of the orbital period are interpreted in terms of motion of a third body around the system and magnetic activity cycle modulating the orbital period of SV Cam via the Applegate (1992) mechanism. The use of the Applegate model for SV Cam has been checked by examining the long term brightness variation and calculating some important parameters of this system. The results of these calculations favor the modulation of the orbital period by the Applegate mechanism.

  14. Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.

    Directory of Open Access Journals (Sweden)

    Jia Yao

    Full Text Available Neurons express two families of transporter-like proteins - Synaptic Vesicle protein 2 (SV2A, B, and C and SV2-related proteins (SVOP and SVOPL. Both families share structural similarity with the Major Facilitator (MF family of transporters. SV2 is present in all neurons and endocrine cells, consistent with it playing a key role in regulated exocytosis. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Furthermore, SVOP is expressed earlier in development than SV2 and is one of the neuronal proteins whose expression declines most during aging. Although SV2 is essential for survival, it is not required for development. Because significant levels of neurotransmission remain in the absence of SV2 it has been proposed that SVOP performs a function similar to that of SV2 that mitigates the phenotype of SV2 knockout mice. To test this, we generated SVOP knockout mice and SVOP/SV2A/SV2B triple knockout mice. Mice lacking SVOP are viable, fertile and phenotypically normal. Measures of neurotransmission and behaviors dependent on the cerebellum and pineal gland revealed no measurable phenotype. SVOP/SV2A/SV2B triple knockout mice did not display a phenotype more severe than mice harboring the SV2A/SV2B gene deletions. These findings support the interpretation that SVOP performs a unique, though subtle, function that is not necessary for survival under normal conditions.

  15. Morphometric brain characterization of refractory obsessive-compulsive disorder: diffeomorphic anatomic registration using exponentiated Lie algebra.

    Science.gov (United States)

    Tang, Wanjie; Li, Bin; Huang, Xiaoqi; Jiang, Xiaoyu; Li, Fei; Wang, Lijuan; Chen, Taolin; Wang, Jinhui; Gong, Qiyong; Yang, Yanchun

    2013-10-01

    Few studies have used neuroimaging to characterize treatment-refractory obsessive-compulsive disorder (OCD). This study sought to explore gray matter structure in patients with treatment-refractory OCD and compare it with that of healthy controls. A total of 18 subjects with treatment-refractory OCD and 26 healthy volunteers were analyzed by MRI using a 3.0-T scanner and voxel-based morphometry (VBM). Diffeomorphic anatomical registration using exponentiated Lie algebra (DARTEL) was used to identify structural changes in gray matter associated with treatment-refractory OCD. A partial correlation model was used to analyze whether morphometric changes were associated with Yale-Brown Obsessive-Compulsive Scale scores and illness duration. Gray matter volume did not differ significantly between the two groups. Treatment-refractory OCD patients showed significantly lower gray matter density than healthy subjects in the left posterior cingulate cortex (PCC) and mediodorsal thalamus (MD) and significantly higher gray matter density in the left dorsal striatum (putamen). These changes did not correlate with symptom severity or illness duration. Our findings provide new evidence of deficits in gray matter density in treatment-refractory OCD patients. These patients may show characteristic density abnormalities in the left PCC, MD and dorsal striatum (putamen), which should be verified in longitudinal studies. © 2013. Published by Elsevier Inc. All rights reserved.

  16. ER Operations Installation of Three FLUTe Soil-Vapor Monitoring Wells (MWL-SV03 MWL-SV04 and MWL-SV05) at the Mixed Waste Landfill.

    Energy Technology Data Exchange (ETDEWEB)

    Copland, John Robin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    This installation report describes the May through July 2014 drilling activities performed for the installation of three multi-port soil-vapor monitoring wells (MWL-SV03, MWL-SV04, and MWL-SV05) at the Mixed Waste Landfill (MWL), which is located at Sandia National Laboratories, New Mexico (SNL/NM). SNL/NM is managed and operated by Sandia Corporation (Sandia), a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy (DOE)/National Nuclear Security Administration. The MWL is designated as Solid Waste Management Unit (SWMU) 76 and is located in Technical Area (TA) III (Figure 1-1). The locations of the three soil-vapor monitoring wells (MWL-SV03, MWL-SV04, and MWL-SV05) are shown in Figure 1-2

  17. Weyl and transverse diffeomorphism invariant spin-2 models in D = 2 + 1

    Energy Technology Data Exchange (ETDEWEB)

    Dalmazi, Denis; Mendonca, E.L. [UNESP-Campus de Guaratingueta-DFQ, Guaratingueta, SP (Brazil); ICTP South American Institute for Fundamental Research, IFT-UNESP, Sao Paulo, SP (Brazil); Santos, A.L.R. dos [UNESP-Campus de Guaratingueta-DFQ, Guaratingueta, SP (Brazil); Ghosh, Subir [ICTP South American Institute for Fundamental Research, IFT-UNESP, Sao Paulo, SP (Brazil); Indian Statistical Institute, Physics and Applied Mathematics Unit, Kolkata (India)

    2017-09-15

    There are two covariant descriptions of massless spin-2 particles in D = 3 + 1 via a symmetric rank-2 tensor: the linearized Einstein-Hilbert (LEH) theory and the Weyl plus transverse diffeomorphism (WTDIFF) invariant model. From the LEH theory one can obtain the linearized new massive gravity (NMG) in D = 2 + 1 via Kaluza-Klein dimensional reduction followed by a dual master action. Here we show that a similar route takes us from the WTDIFF model to a linearized scalar-tensor NMG which belongs to a larger class of consistent spin-0 modifications of NMG. We also show that a traceless master action applied to a parity singlet furnishes two new spin-2 self-dual models. Moreover, we examine the singular replacement h{sub μν} → h{sub μν} - η{sub μν}h/D and prove that it leads to consistent massive spin-2 models in D = 2 + 1. They include linearized versions of unimodular topologically massive gravity (TMG) and unimodular NMG. Although the free part of those unimodular theories are Weyl invariant, we do not expect any improvement in the renormalizability. Both the linearized K-term (in NMG) and the linearized gravitational Chern-Simons term (in TMG) are invariant under longitudinal reparametrizations δh{sub μν} = ∂{sub μ}∂{sub ν}ζ, which is not a symmetry of the WTDIFF Einstein-Hilbert term. Therefore, we still have one degree of freedom whose propagator behaves like 1/p{sup 2} for large momentum. (orig.)

  18. An Inexact Newton-Krylov Algorithm for Constrained Diffeomorphic Image Registration.

    Science.gov (United States)

    Mang, Andreas; Biros, George

    We propose numerical algorithms for solving large deformation diffeomorphic image registration problems. We formulate the nonrigid image registration problem as a problem of optimal control. This leads to an infinite-dimensional partial differential equation (PDE) constrained optimization problem. The PDE constraint consists, in its simplest form, of a hyperbolic transport equation for the evolution of the image intensity. The control variable is the velocity field. Tikhonov regularization on the control ensures well-posedness. We consider standard smoothness regularization based on H(1)- or H(2)-seminorms. We augment this regularization scheme with a constraint on the divergence of the velocity field (control variable) rendering the deformation incompressible (Stokes regularization scheme) and thus ensuring that the determinant of the deformation gradient is equal to one, up to the numerical error. We use a Fourier pseudospectral discretization in space and a Chebyshev pseudospectral discretization in time. The latter allows us to reduce the number of unknowns and enables the time-adaptive inversion for nonstationary velocity fields. We use a preconditioned, globalized, matrix-free, inexact Newton-Krylov method for numerical optimization. A parameter continuation is designed to estimate an optimal regularization parameter. Regularity is ensured by controlling the geometric properties of the deformation field. Overall, we arrive at a black-box solver that exploits computational tools that are precisely tailored for solving the optimality system. We study spectral properties of the Hessian, grid convergence, numerical accuracy, computational efficiency, and deformation regularity of our scheme. We compare the designed Newton-Krylov methods with a globalized Picard method (preconditioned gradient descent). We study the influence of a varying number of unknowns in time. The reported results demonstrate excellent numerical accuracy, guaranteed local deformation

  19. New solutions of the hamiltonian and diffeomorphism constraints of quantum gravity from a highest weight loop representation

    Science.gov (United States)

    Aldaya, V.; Navarro-Salas, J.

    1991-04-01

    We introduce a highest weight type representation of the Rovelli-Smolin algebra of loop observables for quantum gravity. In terms of this representation, new solutions of the hamiltonian and diffeomorphism constraints are given. Assuming the locality of the quantum hamiltonian constraint we show that any functional depending on the generalized link class of the disjoint union of arbitrary simple loops is a solution. Finally we argue that this is the general solution in the irreducible representation space. On leave of absence from the Departamento de Fisica Teorica, Universidad de Valencia, and IFIC, Centro Mixto Universidad de Valencia - CSIC, Burjassot, Spain.

  20. Shorter intervals at peak SV vs.V̇O2max may yield high SV with less physiological stress.

    Science.gov (United States)

    Colakoglu, Muzaffer; Ozkaya, Ozgur; Balci, Gorkem Aybars; Yapicioglu, Bulent

    2015-01-01

    The purpose of this study was to evaluate whether greater and sustainable stroke volume (SV) responses may be obtained by exercise intensities corresponding to peak SV (SVpeak) vs. maximal O2 consumption (VO2max), and short vs. long intervals (SI vs. LI). Nine moderate- to well-trained male athletes competing at regional level specialists of cyclist, track and field volunteered to take part in the study (VO2max: 59.7 ± 7.4 mL·min(-1)·kg(-1)). Following familiarisation sessions, VO2max was determined, and then SVpeak was evaluated using exercise intensities at 40%-100% of VO2max by nitrous-oxide rebreathing (N2ORB) method. Then each separate participant exercised wattages corresponding to individual VO2max and SVpeak during both SI (SIVO2max and SI(SVpeak)) and LI (LIVO2max and LI(SVpeak)) workouts on a cycle ergometer. Main results showed that both SIVO2max and SI(SVpeak) yielded greater SV responses than LIVO2max and LI(SVpeak) (p ≤ 0.05). Mean SV responses were greater in LI(SVpeak) than in LIVO2max (p ≤ 0.05), but there was no statistical difference between SI(SVpeak) and SIVO2max. However, there was significantly less physiological stress based on VO2, respiratory exchange ratio, heart rate and rate of perceived exhaustion in SVpeak than in [Formula: see text] intensities (p ≤ 0.05). Moreover, SV responses at exercise phases increased in the early stages and remain stable until the end of SIVO2max and SI(SVpeak) workouts (p > 0.05), while they were gradually decreasing in LIVO2max and LI(SVpeak) sessions (p ≤ 0.05). In conclusion, if the aim of a training session is to improve SVpeak with less physiological stress, SI(SVpeak) seems a better alternative than other modalities tested in the present study.

  1. Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system

    Energy Technology Data Exchange (ETDEWEB)

    Lau, Aik Jiang; Chang, Thomas K.H., E-mail: thomas.chang@ubc.ca

    2014-06-01

    The naturally occurring SV23 splice variant of human constitutive androstane receptor (hCAR-SV23) is activated by di-(2-ethylhexyl)phthalate (DEHP), which is detected as a contaminant in fetal bovine serum (FBS). In our initial experiment, we compared the effect of dialyzed FBS, charcoal-stripped, dextran-treated FBS (CS-FBS), and regular FBS on the basal activity and ligand-activation of hCAR-SV23 in a cell-based reporter gene assay. In transfected HepG2 cells cultured in medium supplemented with 10% FBS, basal hCAR-SV23 activity varied with the type of FBS (regular > dialyzed > CS). DEHP increased hCAR-SV23 activity when 10% CS-FBS, but not regular FBS or dialyzed FBS, was used. With increasing concentrations (1–10%) of regular FBS or CS-FBS, hCAR-SV23 basal activity increased, whereas in DEHP-treated cells, hCAR-SV23 activity remained similar (regular FBS) or slightly increased (CS-FBS). Subsequent experiments identified a serum-free culture condition to detect DEHP activation of hCAR-SV23. Under this condition, artemisinin, artemether, and arteether increased hCAR-SV23 activity, whereas they decreased it in cells cultured in medium supplemented with 10% regular FBS. By comparison, FBS increased the basal activity of the wild-type isoform of hCAR (hCAR-WT), whereas it did not affect the basal activity of the SV24 splice variant (hCAR-SV24) or ligand activation of hCAR-SV24 and hCAR-WT by 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO). The use of serum-free culture condition was suitable for detecting CITCO activation of hCAR-WT and hCAR-SV24. In conclusion, FBS leads to erroneous classification of pharmacological ligands of hCAR-SV23 in cell-based assays, but investigations on functional ligands of hCAR isoforms can be conducted in serum-free culture condition. - Highlights: • FBS leads to erroneous pharmacological classification of hCAR-SV23 ligands. • Artemisinin, artemether, and arteether activate hCAR-SV

  2. SV40 Infection of Mesenchymal Stromal Cells From Wharton's Jelly Drives the Production of Inflammatory and Tumoral Mediators.

    Science.gov (United States)

    Cason, Carolina; Campisciano, Giuseppina; Zanotta, Nunzia; Valencic, Erica; Delbue, Serena; Bella, Ramona; Comar, Manola

    2017-11-01

    The Mesenchymal Stromal Cells from umbilical cord Wharton's jelly (WJSCs) are a source of cells with high potentiality for the treatment of human immunological disorders. Footprints of the oncogenic viruses Simian Virus 40 (SV40) and JC Virus (JCPyV) have been recently detected in human WJSCs specimens. The aim of this study is to evaluate if WJSCs can be efficiently infected by these Polyomaviruses and if they can potentially exert tumoral activity. Cell culture experiments indicated that WJSCs could sustain both SV40 and JCPyV infections. A transient and lytic replication was observed for JCPyV, while SV40 persistently infected WJSCs over a long period of time, releasing a viral progeny at low titer without evident cytopathic effect (CPE). Considering the association between SV40 and human tumors and the reported ability of the oncogenic viruses to drive the host innate immune response to cell transformation, the expression profile of a large panel of immune mediators was evaluated in supernatants by the Bioplex platform. RANTES, IL-3, MIG, and IL-12p40, involved in chronic inflammation, cells differentiation, and transformation, were constantly measured at high concentration comparing to control. These findings represent a new aspect of SV40 biological activity in the humans, highlighting its interaction with specific host cellular pathways. In view of these results, it seems to be increasingly urgent to consider Polyomaviruses in the management of WJSCs for their safely use as promising therapeutic source. J. Cell. Physiol. 232: 3060-3066, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens.

    Science.gov (United States)

    Levin, M J; Oxman, M N; Diamandopoulos, G T; Levine, A S; Henry, P H; Enders, J F

    1969-02-01

    A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome.

  4. VIRUS-SPECIFIC NUCLEIC ACIDS IN SV40-EXPOSED HAMSTER EMBRYO CELL LINES: CORRELATION WITH S AND T ANTIGENS*

    Science.gov (United States)

    Levin, Myron J.; Oxman, Michael N.; Diamandopoulos, George Th.; Levine, Arthur S.; Henry, Patrick H.; Enders, John F.

    1969-01-01

    A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome. PMID:4307716

  5. Levetiracetam reverses synaptic deficits produced by overexpression of SV2A.

    Directory of Open Access Journals (Sweden)

    Amy Nowack

    Full Text Available Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effects of excess SV2A in autaptic hippocampal neurons. Expression of an SV2A-EGFP fusion protein produced a ∼1.5-fold increase in synaptic levels of SV2, and resulted in reduced synaptic release probability. The overexpression phenotype parallels that seen in neurons from SV2 knockout mice, which experience severe seizures. Overexpression of SV2A also increased synaptic levels of the calcium-sensor protein synaptotagmin, an SV2-binding protein whose stability and trafficking are regulated by SV2. Treatment with levetiracetam rescued normal neurotransmission and restored normal levels of SV2 and synaptotagmin at the synapse. These results indicate that changes in SV2 expression in either direction impact neurotransmission, and suggest that levetiracetam may modulate SV2 protein interactions.

  6. Biologic properties of viable deletion mutants of simian virus 40 (SV40) rescued from the cells of an SV40-induced hamster lymphocytic leukemia.

    Science.gov (United States)

    Diamandopoulos, G T; Carmichael, G

    1983-12-01

    A lymphocytic leukemia induced by the oncogenic DNA simian virus 40 (SV40) in an inbred LSH/SsLak Syrian golden hamster was evoked to produce infectious SV40 by fusion of the leukemia cells with grivet monkey kidney (GMK) cells and by exposure of the leukemia cells to the chemical inducers mitomycin C and cycloheximide. Plaque-purified viable substrains of the rescued SV40 when studied by restriction endonuclease digestion of viral DNA were found to contain small deletions within the Hind III restriction fragment C. These deletions lay near the viral origin of DNA replication. Ten plaque-purified substrains of the rescued virus identified by immunofluorescence as being SV40 were found, when compared to the wild-type SV40, to replicate slowly and to form small plaques. Although these substrains transformed NIH/3T3 cells as efficiently as the wild-type SV40 in tissue culture, they were generally less oncogenic in vivo--7 of the 10 failed to induce tumors. The 3 oncogenic SV40-rescued substrains were not found to exhibit "lymphocytotropism," i.e., the capacity to infect and neoplastically transform preferentially hamster lymphocytes. Thus the hamster lymphocytic leukemia originally induced by the wild-type SV40 was most likely a chance-stochastic event rather than the result of tropism-determinism mediated by the virus, as is usually the case with leukemogenic RNA viruses.

  7. OPERATIONAL AND MAINTENANCE FEATURES OF THE SV. TRI KRALJA TUNNEL

    Directory of Open Access Journals (Sweden)

    Zvonimir Deković

    2013-12-01

    Full Text Available The paper focuses on the features of the operation and maintenance of tunnels on the Zagreb-Macelj motorway. When it comes to the operation and maintenance of a series of six tunnels on the Zagreb-Macelj motorway, Sv. Tri Kralja Tunnel is the most challenging structure on the motorway, where it is necessary to provide an adequate level of safety and operability. Tunnel operation is ensured by the concession model of public - private partnership, which is applied to the Zagreb – Macelj motorway. Features of the tunnel infrastructure maintenance are emphasized, as well as importance of the extraordinary maintenance of the tunnel infrastructure. The goal of the tunnel operation and maintenance is to ensure undisturbed and safe traffic flow through the tunnels, by keeping the tunnel in normal functional conditions.

  8. Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.

    Science.gov (United States)

    Elmishad, A G; Bocchetta, M; Pass, H I; Carbone, M

    2006-01-01

    Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human tumours has been linked to the administration of SV40-contaminated polio vaccines from 1954 until 1963. Many of these reports linked SV40 to human mesothelioma. Some studies have failed to detect SV40 in human tumours and this has caused a controversy. Here we review the current literature. Moreover, we present evidence showing how differences in the sensitivities of methodologies can lead to a very different interpretation of the same study. The same 20 mesothelioma specimens all tested negative, 2/20 tested positive or 7/20 tested positive for SV40 Tag by simply changing the detection method on the same immuno-precipitation/western blot membranes. These results provide a simple explanation for some of the apparent discordant results reported in the literature.

  9. Lorentz-diffeomorphism quasi-local conserved charges and Virasoro algebra in Chern–Simons-like theories of gravity

    Directory of Open Access Journals (Sweden)

    M.R. Setare

    2016-08-01

    Full Text Available The Chern–Simons-like theories of gravity (CSLTG are formulated at first order formalism. In this formalism, the derivation of the entropy of a black hole on bifurcation surface, as a quasi-local conserved charge is problematic. In this paper we overcome these problems by considering the concept of total variation and the Lorentz–Lie derivative. We firstly find an expression for the ADT conserved current in the context of the CSLTG which is based on the concept of the Killing vector fields. Then, we generalize it to be conserved for all diffeomorphism generators. Thus, we can extract an off-shell conserved charge for any vector field which generates a diffeomorphism. The formalism presented here is based on the concept of quasi-local conserved charges which are off-shell. The charges can be calculated on any codimension two space-like surface surrounding a black hole and the results are independent of the chosen surface. By using the off-shell quasi-local conserved charge, we investigate the Virasoro algebra and find a formula to calculate the central extension term. We apply the formalism to the BTZ black hole solution in the context of the Einstein gravity and the Generalized massive gravity, then we find the eigenvalues of their Virasoro generators as well as the corresponding central charges. Eventually, we calculate the entropy of the BTZ black hole by the Cardy formula and we show that the result exactly matches the one obtained by the concept of the off-shell conserved charges.

  10. SV-AUTOPILOT: optimized, automated construction of structural variation discovery and benchmarking pipelines.

    Science.gov (United States)

    Leung, Wai Yi; Marschall, Tobias; Paudel, Yogesh; Falquet, Laurent; Mei, Hailiang; Schönhuth, Alexander; Maoz Moss, Tiffanie Yael

    2015-03-25

    Many tools exist to predict structural variants (SVs), utilizing a variety of algorithms. However, they have largely been developed and tested on human germline or somatic (e.g. cancer) variation. It seems appropriate to exploit this wealth of technology available for humans also for other species. Objectives of this work included: a) Creating an automated, standardized pipeline for SV prediction. b) Identifying the best tool(s) for SV prediction through benchmarking. c) Providing a statistically sound method for merging SV calls. The SV-AUTOPILOT meta-tool platform is an automated pipeline for standardization of SV prediction and SV tool development in paired-end next-generation sequencing (NGS) analysis. SV-AUTOPILOT comes in the form of a virtual machine, which includes all datasets, tools and algorithms presented here. The virtual machine easily allows one to add, replace and update genomes, SV callers and post-processing routines and therefore provides an easy, out-of-the-box environment for complex SV discovery tasks. SV-AUTOPILOT was used to make a direct comparison between 7 popular SV tools on the Arabidopsis thaliana genome using the Landsberg (Ler) ecotype as a standardized dataset. Recall and precision measurements suggest that Pindel and Clever were the most adaptable to this dataset across all size ranges while Delly performed well for SVs larger than 250 nucleotides. A novel, statistically-sound merging process, which can control the false discovery rate, reduced the false positive rate on the Arabidopsis benchmark dataset used here by >60%. SV-AUTOPILOT provides a meta-tool platform for future SV tool development and the benchmarking of tools on other genomes using a standardized pipeline. It optimizes detection of SVs in non-human genomes using statistically robust merging. The benchmarking in this study has demonstrated the power of 7 different SV tools for analyzing different size classes and types of structural variants. The optional merge

  11. Goddard High Resolution Spectrograph SV/GTO Project

    Science.gov (United States)

    Ebbets, Dennis

    1999-03-01

    Contract number NAS5-30433, known at Ball Aerospace as the GHRS SV/GTO project, supported our participation in the post-launch activities of the Goddard High Resolution Spectrograph aboard the Hubble Space Telescope. The period of performance was December 1988 through December 1998. The contract supported the involvement of Dr Dennis Ebbets in the work of the GHRS Investigation Definition Team, and several of the Ball people in the documentation and publication of results. Three main categories of tasks were covered by this contract; in-orbit calibration of the GHRS, guaranteed time observations, and education and public outreach. The nature and accomplishments of these tasks are described in the report. This summary makes many references to publications in the scientific and technical literature. Appendix A is extracted from a complete bibliography, and lists those papers that are directly related to work performed under this GHRS contract. The tasks related to the in-orbit calibration of the GHRS were by far the largest responsibility during the first six years of the project. During this period Dr. Ebbets was responsible for the definition of calibration requirements, design of experiments, preparation of observing proposals, tracking their implementation and execution, and coordinating the analysis and publication of the results. Prior to the launch of HST in 1990 the observing proposals were developed in cooperation with the scientists on the GHRS DDT, engineers at Ball Aerospace, the operations staff at the STScI, and project coordinators at GSFC.

  12. PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV ...

    Indian Academy of Sciences (India)

    Sandra Feijoo Bandin

    P16858|G3P_MOUSE. Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2 sp|P19783|COX41_MOUSE. Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus GN=Cox4i1 PE=1 SV=2.

  13. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.

    Directory of Open Access Journals (Sweden)

    Lisheng Peng

    2011-03-01

    Full Text Available Botulinum neurotoxins (BoNTs include seven bacterial toxins (BoNT/A-G that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippocampal neurons via synaptic vesicle recycling and can bind SV2 in brain detergent extracts. BoNT/D failed to bind and enter neurons lacking SV2, which can be rescued by expressing one of the three SV2 isoforms (SV2A/B/C. Localization of SV2 on plasma membranes mediated BoNT/D binding in both neurons and HEK293 cells. Furthermore, chimeric receptors containing the binding sites for BoNT/A and E, two other BoNTs that use SV2 as receptors, failed to mediate the entry of BoNT/D suggesting that BoNT/D binds SV2 via a mechanism distinct from BoNT/A and E. Finally, we demonstrated that gangliosides are essential for the binding and entry of BoNT/D into neurons and for its toxicity in vivo, supporting a double-receptor model for this toxin.

  14. Reflection of quasi-P and quasi-SV waves at the free and rigid ...

    Indian Academy of Sciences (India)

    The propagation of plane waves in fibre-reinforced media is discussed. The expressions of phase velocities of quasi-P (qP) and quasi-SV (qSV) waves propagating in plane symmetry are obtained in terms of propagation vectors. We have established a relation from which the displacement vector can be obtained in terms of ...

  15. Reflection of P and SV waves from free surface of an elastic solid ...

    Indian Academy of Sciences (India)

    The governing equations for generalized thermodiffusion in an elastic solid are solved. There exists three kinds of dilatational waves and a Shear Vertical (SV) wave in a two-dimensional model of the solid. The reflection phenomena of P and SV waves from free surface of an elastic solid with thermodiffusion is considered.

  16. Reflection of quasi-P and quasi-SV waves at the free and rigid ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    waves reflected on free and rigid boundaries due to incident qP and qSV waves are also obtained and presented graphically. Keywords. Reflection of waves; quasi-P waves; quasi-SV waves; quasi-SH waves; fibre-reinforced media; reflection coefficients. 1. Introduction. Fibre-reinforced composite materials have become ...

  17. An investigation of the occurrence of sv40 antibodies in South Africa ...

    African Journals Online (AJOL)

    Four of the samples were from the healthy population group and the remaining 1 (1/64) was from the patient group. An SV40 antibody-blocking assay and a Western blot were used as additional confirmation for the SV40 antibodies, whereas the Western blot assay developed a single common band on all 5 samples.

  18. Observational Constraints on Terpene Oxidation with and without Anthropogenic Influence in the Amazon using Speciated Measurements from SV-TAG

    Science.gov (United States)

    Yee, L.; Isaacman, G. A.; Kreisberg, N. M.; Liu, Y.; McKinney, K. A.; de Sá, S. S.; Martin, S. T.; Alexander, M. L.; Palm, B. B.; Hu, W.; Campuzano Jost, P.; Day, D. A.; Jimenez, J. L.; Viegas, J.; Springston, S. R.; Wurm, F.; Ferreira De Brito, J.; Artaxo, P.; Manzi, A. O.; Machado, L.; Longo, K.; Oliveira, M. B.; Souza, R. A. F. D.; Hering, S. V.; Goldstein, A. H.

    2014-12-01

    Biogenic volatile organic compounds (BVOCs) from the Amazon forest represent the largest regional source of organic carbon emissions to the atmosphere. These BVOC emissions dominantly consist of volatile and semi-volatile terpenoid compounds that undergo chemical transformations in the atmosphere to form oxygenated condensable gases and secondary organic aerosol (SOA). However, the oxidation pathways of these compounds are still not well understood, and are expected to differ significantly between "pristine" conditions, as is common in Amazonia, and polluted conditions caused by emissions from growing cities. Our focus is to elucidate how anthropogenic emissions influence BVOC chemistry and BSOA formation through speciated measurements of their oxidation products. We have deployed the Semi-Volatile Thermal desorption Aerosol Gas Chromatograph (SV-TAG) at the rural T3 site located west of the urban center of Manaus, Brazil as part of the Green Ocean Amazon (GoAmazon) 2014 field campaign to measure hourly concentrations of semi-volatile BVOCs and their oxidation products during the wet and dry seasons. Primary BVOC concentrations measured by the SV-TAG include sesquiterpenes and diterpenes, which have rarely been speciated with high time-resolution. We observe sesquiterpenes to be anti-correlated with ozone, indicative of sesquiterpene oxidation playing a major role in the regional oxidant budget. The role of sesquiterpenes in atmospheric SOA formation are of interest due to their high aerosol yields and high reactivity with ozone, relative to more commonly measured BVOCs (e.g. monoterpenes). We explore relative concentrations of sesquiterpenes and monoterpenes and their roles as precursors to SOA formation by combining SV-TAG measurements with those from an additional suite of VOC and particle measurements deployed in the Amazon. We also report the first ever hourly observations of the gas-particle partitioning of speciated terpene oxidation products in the Amazon

  19. Spectroscopic observations of the RS CVn-type binary systems SV Cam and XY UMa

    Science.gov (United States)

    Rainger, P. P.; Hilditch, R. W.; Edwin, R. P.

    1991-01-01

    Radial velocities of the primary components of the two RS CVn-type binary systems SV Cam and XY UMa are presented, for the first time for XY UMa. Neither secondary component could be detected. A change of 5.0 + or - 13 km/sec in the systemic velocity of SV Cam is found over 40 years, which lends some support to the current model of SV Cam being a triple system. If the masses of the G3 V primary components of both systems are assumed to be 1 solar mass, then the secondaries are 0.7 (SV Cam) and 0.6 (XY UMa) solar masses; all four stars are main sequence objects with SV Cam being rather more evolved than XY UMa.

  20. Spectroscopic observations of the RS CVn-type binary systems SV Cam and XY UMa

    Energy Technology Data Exchange (ETDEWEB)

    Rainger, P.P.; Hilditch, R.W.; Edwin, R.P. (Saint Andrews Univ. (UK). Observatory)

    1991-01-01

    Radial velocities of the primary components of the two RS CVn-type binary systems SV Cam and XY UMa are presented, for the first time for XY UMa. Neither secondary component could be detected. A change of 5.0+-1.3km s{sup -1} in the systemic velocity of SV Cam is found over 40 years which lends some support to the current model of SV Cam being a triple system. If the masses of the G3 V primary components of both systems are assumed to be one solar mass, then the secondaries are 0.7 (SV CAM) and 0.6 (XY UMa) solar masses; all four stars are main sequence objects with SV Cam being rather more evolved than XY UMa. (author).

  1. SV40 DNA amplification and reintegration in surviving hamster cells after 60Co gamma-irradiation.

    Science.gov (United States)

    Lücke-Huhle, C; Pech, M; Herrlich, P

    1990-10-01

    SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 sequences was pursued over a period of 20 days following radiation exposure. As shown by colony hybridization, integrated SV40 sequences were amplified in surviving and non-surviving cells. At later times, however, clonal sublines of surviving cells grown for 20-30 cell generations after irradiation had lost most of their amplified SV40 copies but showed altered restriction fragment patterns indicating reintegration of SV40 sequences at new sites of the hamster genome. This suggests that 60Co gamma-irradiation can generate mutations by inducing over-replication of chromosome segments that are then substrates of enzymatic rearrangements.

  2. Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.

    Science.gov (United States)

    Dunn, Amy R; Hoffman, Carlie A; Stout, Kristen A; Ozawa, Minagi; Dhamsania, Rohan K; Miller, Gary W

    2017-12-21

    The synaptic vesicle glycoprotein 2C (SV2C) is an undercharacterized protein with enriched expression in phylogenetically old brain regions. Its precise role within the brain is unclear, though various lines of evidence suggest that SV2C is involved in the function of synaptic vesicles through the regulation of vesicular trafficking, calcium-induced exocytosis, or synaptotagmin function. SV2C has been linked to multiple neurological disorders, including Parkinson's disease and psychiatric conditions. SV2C is expressed in various cell types-primarily dopaminergic, GABAergic, and cholinergic cells. In mice, it is most highly expressed in nuclei within the basal ganglia, though it is unknown if this pattern of expression is consistent across species. Here, we use a custom SV2C-specific antiserum to describe localization within the brain of mouse, nonhuman primate, and human, including cell-type localization. We found that the immunoreactivity with this antiserum is consistent with previously-published antibodies, and confirmed localization of SV2C in the basal ganglia of rodent, rhesus macaque, and human. We observed strongest expression of SV2C in the substantia nigra, ventral tegmental area, dorsal striatum, pallidum, and nucleus accumbens of each species. Further, we demonstrate colocalization between SV2C and markers of dopaminergic, GABAergic, and cholinergic neurons within these brain regions. SV2C has been increasingly linked to dopamine and basal ganglia function. These antisera will be an important resource moving forward in our understanding of the role of SV2C in vesicle dynamics and neurological disease. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Individual and Institutional Predictors of IPV/SV Screening in College Health Centers.

    Science.gov (United States)

    Sutherland, Melissa A; Fantasia, Heidi Collins; Hutchinson, M Katherine; Katz, Jennifer

    2017-11-01

    Intimate partner violence (IPV) and sexual violence (SV) are significant public health issues for women, particularly for college women. IPV and SV have been associated with numerous adverse health consequences and involvement in unhealthy behaviors. Given the health risks and high rates of IPV/SV among college women, it is important to understand and promote screening in this population. The purpose of this study was to examine college women's experiences with IPV/SV screening at college health centers and identify individual and institutional characteristics associated with screening. Random samples of female undergraduate college students from five colleges in the northeast United States were recruited to participate in an anonymous online survey in January 2015. Inclusion criteria included at least one visit to the college health center during the preceding fall semester. Participants were questioned regarding demographics and whether they were screened or asked about IPV/SV at the college health center. A total of 873 women met the inclusion criteria and completed surveys. Only 10.2% of the college women in the study reported that they were screened for IPV/SV at their most recent visit to the college health center. Participants from public colleges/universities were 3 times more likely than others to report screening, whereas participants from urban college/university campuses were more than twice as likely as others to report screening. College women who went to the college health center for a gynecological or sexual health reason were nearly 4 times as likely as other women to report being screened for IPV/SV. Low rates of IPV/SV screening at college health centers represent missed opportunities. Further research across more numerous and diverse college sites is needed to understand the factors that promote or inhibit IPV/SV screening in college health centers to develop interventions to facilitate routine screening practices.

  4. Voxel-based morphometric analysis in hypothyroidism using diffeomorphic anatomic registration via an exponentiated lie algebra algorithm approach.

    Science.gov (United States)

    Singh, S; Modi, S; Bagga, D; Kaur, P; Shankar, L R; Khushu, S

    2013-03-01

    The present study aimed to investigate whether brain morphological differences exist between adult hypothyroid subjects and age-matched controls using voxel-based morphometry (VBM) with diffeomorphic anatomic registration via an exponentiated lie algebra algorithm (DARTEL) approach. High-resolution structural magnetic resonance images were taken in ten healthy controls and ten hypothyroid subjects. The analysis was conducted using statistical parametric mapping. The VBM study revealed a reduction in grey matter volume in the left postcentral gyrus and cerebellum of hypothyroid subjects compared to controls. A significant reduction in white matter volume was also found in the cerebellum, right inferior and middle frontal gyrus, right precentral gyrus, right inferior occipital gyrus and right temporal gyrus of hypothyroid patients compared to healthy controls. Moreover, no meaningful cluster for greater grey or white matter volume was obtained in hypothyroid subjects compared to controls. Our study is the first VBM study of hypothyroidism in an adult population and suggests that, compared to controls, this disorder is associated with differences in brain morphology in areas corresponding to known functional deficits in attention, language, motor speed, visuospatial processing and memory in hypothyroidism. © 2012 British Society for Neuroendocrinology.

  5. Illusory double epenthesis in the [s_V] context among Japanese listeners: an exploratory study.

    Science.gov (United States)

    Yamada, Jun

    2012-10-01

    Previous studies showed that English listeners tend to hear an [s_V] segment with [_] a silent gap as [sCV], where [C] is an epenthetic stop consonant such as [t]. The present study found that Japanese listeners, whose native language disallows [CCV] but allows [CVCV], often perceive [s_V] as [sVCV]. It is suggested that such illusory double-epenthetic percepts are generated via a two-step process, i.e., the vowel of [s_V] triggers an epenthetic consonant before it, and the initial consonant [s] and the newly generated epenthetic consonant [C] sequentially aligned induce a vowel epenthesis [V] between them.

  6. Fanconi anemia patients are more susceptible to infection with tumor virus SV40.

    Directory of Open Access Journals (Sweden)

    Manola Comar

    Full Text Available Fanconi anemia (FA is a recessive DNA repair disease characterized by a high predisposition to developing neoplasms. DNA tumor polyomavirus simian virus 40 (SV40 transforms FA fibroblasts at high efficiency suggesting that FA patients could be highly susceptible to SV40 infection. To test this hypothesis, the large tumor (LT antigen of SV40, BKV, JCV and Merkel Cell (MC polyomaviruses were tested in blood samples from 89 FA patients and from 82 of their parents. Two control groups consisting of 47 no-FA patients affected by other genetic bone marrow failure diseases and 91 healthy subjects were also evaluated. Although JCV, BKV and MC were not found in any of the FA samples, the prevalence and viral load of SV40 were higher in FA patients (25%; mean viral load: 1.1×10(2 copies/10(5cells as compared with healthy individuals (4.3%; mean viral load: 0.8×10(1 copies/10(5cells and genetic controls (0% (p<0.005. A marked age-dependent frequency of SV40 was found in FA with respect to healthy subjects suggesting that, although acquired early in life, the virus can widespread more easily in specific groups of population. From the analysis of family pedigrees, 60% of the parents of SV40-positive probands were positive for the virus compared to 2% of the parents of the SV40-negative probands (p<0.005. It is worthy of note that the relative frequency of SV40-positive relatives detected in this study was the highest ever reported, showing that asymptomatic FA carriers are also more susceptible to SV40. In conclusion, we favor the hypothesis that SV40 spread could be facilitated by individuals who are genetically more susceptible to infection, such as FA patients. The increased susceptibility to SV40 infection seems to be associated with a specific defect of the immune system which supports a potential interplay of SV40 with an underlying genetic alteration that increases the risk of malignancies.

  7. GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background.

    NARCIS (Netherlands)

    Pattij, T.; Groenink, L.; Oosting, R.S.; Gugten, J. van der; Maes, R.A.A.; Olivier, B.

    2002-01-01

    Previous studies in 5-HT(1A) receptor knockout (1AKO) mice on a mixed Swiss Websterx129/Sv (SWx129/Sv) and a pure 129/Sv genetic background suggest a differential gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor complex sensitivity in both strains, independent from the anxious phenotype. To

  8. Highly accurate P-SV complete synthetic seismograms using modified DSM operators

    Science.gov (United States)

    Takeuchi, Nozomu; Geller, Robert J.; Cummins, Phil R.

    In previous papers [Cummins et al., 1994ab] (hereafter referred to as DSMI and DSMII respectively), we presented accurate methods for computing complete synthetic seismograms for SH and P-SV respectively in a spherical earth model. The SH calculations used computationally efficient modified matrix operators, but the P-SV synthetics were computationally intensive. Geller and Takeuchi [1995] (hereafter referred to as GT95) presented a general theory for deriving modified operators and gave the explicit form of the modified operators for the P-SV case in cylindrical or cartesian coordinates. In this paper we extend GT95's results to derive modified operators for the P-SV case in spherical coordinates. The use of the modified operators reduces the CPU time by a factor of about 5 without a loss of accuracy. 10 CPU min on a SPARC-20 workstation with one CPU are required to compute a profile of synthetic seismograms from DC to 20 sec period.

  9. Når børn lærer at svømme

    DEFF Research Database (Denmark)

    2006-01-01

    DVD'en giver svømmeinstruktøren indblik i og viden om, hvordan børn lærer at svømme. DVD'en indeholder kapitler om Kroppen i vand, Vandbasis, Butterfly, Rygcrawl, Brystsvømning, Crawl, Livredning og Aktivitetsjustering. I hvert kapitel tages der udgangspunkt i begyndersvømmerens typiske bevægelser...

  10. In vitro and in vivo Functional Characterization of Gutless Recombinant SV40-derived CFTR Vectors

    Science.gov (United States)

    Mueller, Christian; Strayer, Marlene S; Sirninger, Jeffery; Braag, Sofia; Branco, Francisco; Louboutin, Jean-Pierre; Flotte, Terence R.; Strayer, David S.

    2009-01-01

    In cystic fibrosis (CF) respiratory failure caused by progressive airway obstruction and tissue damage is primarily a result of the aberrant inflammatory responses to lung infections with Pseudomonas aeruginosa. Despite considerable improvement in patient survival, conventional therapies are mainly supportive. Recent progress towards gene therapy for CF has been encouraging; however, several factors such as immune response and transduced cell turnover remain as potential limitations to CF gene therapy. As alternative gene therapy vectors for CF we examined the feasibility of using SV40-derived vectors (rSV40s) which may circumvent some of these obstacles. To accommodate the large CFTR cDNA, we removed not only SV40 Tag genes, but also all capsid genes. We therefore tested whether “gutless” rSV40s could be packaged and were able to express a functional human CFTR cDNA. Results from our in vitro analysis determined that rSV40-CFTR was able to successfully result in the expression of CFTR protein which localized to the plasma membrane and restored channel function to CFTR deficient cells. Similarly in vivo experiments delivering rSV40-CFTR to the lungs of Cftr−/− mice resulted in a reduction of the pathology associated with intra-tracheal pseudomona aeruginosa challenge. rSV40-CFTR treated mice had had less weight loss when compared to control treated mice as well as demonstrably reduced lung inflammation as evidence by histology and reduced inflammatory cytokines in the BAL. The reduction in inflammatory cytokine levels led to an evident decrease in neutrophil influx to the airways. These results indicate that further study of the application of rSV40-CFTR to CF gene therapy is warranted. PMID:19890354

  11. Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque.

    Science.gov (United States)

    Song, M; Mulvihill, M S; Williams, K D; Collins, B H; Kirk, A D

    2018-02-01

    Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal interstitial pneumonia in an immunosuppressed host following renal allotransplantation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Dissociation of DNA damage and mitochondrial injury caused by hydrogen peroxide in SV-40 transformed lung epithelial cells

    Directory of Open Access Journals (Sweden)

    Adcock Ian M

    2002-11-01

    Full Text Available Abstract Background Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs, the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidative stress. We compared the extent of oxidative DNA damage with that of mitochondrial injury in lung epithelial cells at the single cell level. Result DNA damage and mitochondrial injury were measured after oxidative stress in the SV-40 transformed lung epithelial cell line challenged with hydrogen peroxide (H2O2. Single cell analysis of DNA damage was determined by assessing the number of 8-oxo-2-deoxyguanosine (8-oxo-dG positive cells, a marker of DNA modification, and the length of a comet tail. Mitochondrial membrane potential, ΔΨm, was determined using JC-1. A 1 h pulse of H2O2 induced small amounts of apoptosis (3%. 8-oxo-dG-positive cells and the length of the comet tail increased within 1 h of exposure to H2O2. The number of cells with reduced ΔΨm increased after the addition of H2O2 in a concentration-dependent manner. In spite of a continual loss of ΔΨm, DNA fragmentation was reduced 2 h after exposure to H2O2. Conclusion The data suggest that SV-40 transformed lung epithelial cells are resistant to oxidative stress, showing that DNA damage can be dissociated from mitochondrial injury.

  13. Temperature-sensitive SV40-immortalized rat middle ear epithelial cells.

    Science.gov (United States)

    Toyama, Katsuhiro; Kim, Youngki; Paparella, Michael M; Lin, Jizhen

    2004-12-01

    The proliferation and differentiation of middle ear epithelial cells are essential in both normal and diseased middle ears. The normal situation involves physiologic growth and renewal of the epithelium, and the diseased situation involves pathological changes of the epithelium such as mucous cell metaplasia and ciliated cell proliferation in otitis media. In this study, we used a temperature-sensitive large T antigen (the SV40 mutant) to transduce and immortalize the primary culture of middle ear epithelial cells. SV40-immortalized middle ear epithelial cells have been cultured for more than 50 passages and are stable morphologically. Their nonimmortalized parent cells died at the second passage. Immortalized middle ear epithelial cells carrying the SV40 mutant show a monolayer, cobblestonelike morphology. The cell line expresses characteristic middle ear mucosal molecules such as mucins, keratins, and collagens. It also responds to temperature changes; namely, cells proliferate at 33 degrees C, when the SV40 antigen is active, and differentiate at 39 degrees C, when the SV40 antigen is inactive. Therefore, we conclude that a temperature-sensitive middle ear epithelial cell line has successfully been established.

  14. Dynamic VaR Measurement of Gold Market with SV-T-MN Model

    Directory of Open Access Journals (Sweden)

    Fenglan Li

    2017-01-01

    Full Text Available VaR (Value at Risk in the gold market was measured and predicted by combining stochastic volatility (SV model with extreme value theory. Firstly, for the fat tail and volatility persistence characteristics in gold market return series, the gold price return volatility was modeled by SV-T-MN (SV-T with Mixture-of-Normal distribution model based on state space. Secondly, future sample volatility prediction was realized by using approximate filtering algorithm. Finally, extreme value theory based on generalized Pareto distribution was applied to measure dynamic risk value (VaR of gold market return. Through the proposed model on the price of gold, empirical analysis was investigated; the results show that presented combined model can measure and predict Value at Risk of the gold market reasonably and effectively and enable investors to further understand the extreme risk of gold market and take coping strategies actively.

  15. Kvinder indlagt med svær præeklampsi efterlyser sammenhæng

    DEFF Research Database (Denmark)

    Stenshøj, Jette; Aagaard, Hanne

    2014-01-01

    Præeklampsi rammer 2-5 % af alle gravide i Danmark. Sygdommen kan udvikle sig alvorligt og eneste behandling er forløsning af det ofte præmature barn. Kvinder med svær præeklampsi gennemlever psykologisk stress, og de er samtidig i risiko for en efterfødselsreaktion. Formålet med studiet er......, at undersøge kvinders oplevelse og vurdering af den stress, der kan være forbundet med indlæggelse med svær præeklampsi. Studiet er baseret på interview med tre kvinder efter indlæggelse med svær præeklampsi. Benner og Wrubels forståelse af stress er anvendt som teoretisk ramme for udarbejdelse af...

  16. Solid state fermentation and production of rifamycin SV using Amycolatopsis mediterranei.

    Science.gov (United States)

    Nagavalli, M; Ponamgi, S P D; Girijashankar, V; Venkateswar Rao, L

    2015-01-01

    Production of Rifamycin SV from cheaper agro-industrial by-products using mutant strain of Amycolatopsis mediterranei OVA5-E7 in solid state fermentation (SSF) was optimized. Among the agro-based substrates used, ragi bran was found suitable for maximizing the yield of Rifamycin SV (1310 mg 100 g(-1) ds). The yield can be further enhanced to 19·7 g Kg(-1) of dry substrate by supplementing the substrate with deoiled cotton cake (10% w/w) using optimized fermentation parameters such as maintaining 80% moisture, pH 7·0, 30°C incubation temperature, inoculum 25% v/w and carrying the solid state fermenting for 9 days. Manipulating these seven specifications, the end product yield achieved in our experimentation was 20 g of Rifamycin SV Kg(-1) ds. Eventually, an overall 5-fold improvement in Rifamycin SV production was achieved. Antibiotics such as rifamycin are broad-spectrum antimicrobial drugs used in large-scale worldwide as human medicine towards controlling diseases. Amycolatopsis mediterranei strain which produces this antibiotic was earlier used in submerged fermentation yielded lower amounts of rifamycin. By employing cheaper agro-industrial by-products, we produced upto 20 g rifamycin SV per Kg dry substrate used under optimized solid state fermentation conditions. Keeping in view, the role of rifamycin in meeting the medical demands of world's increasing population; we successfully used an improved strain on cheaper substrates with optimized fermentation parameters and achieved a 5-fold improvement in rifamycin SV production. © 2014 The Society for Applied Microbiology.

  17. Reflection of P and SV waves at the free surface of a monoclinic ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 111; Issue 4. Reflection of and SV waves at the free surface of a monoclinic elastic half- ... the variation of the reflection coefficients with the angle of incidence. The present analysis corrects some fundamental errors appearing in recent papers on the subject.

  18. A very late viral protein triggers the lytic release of SV40.

    Directory of Open Access Journals (Sweden)

    Robert Daniels

    2007-07-01

    Full Text Available How nonenveloped viruses such as simian virus 40 (SV40 trigger the lytic release of their progeny is poorly understood. Here, we demonstrate that SV40 expresses a novel later protein termed VP4 that triggers the timely lytic release of its progeny. Like VP3, VP4 synthesis initiates from a downstream AUG start codon within the VP2 transcript and localizes to the nucleus. However, VP4 expression occurs approximately 24 h later at a time that coincides with cell lysis, and it is not incorporated into mature virions. Mutation of the VP4 initiation codon from the SV40 genome delayed lysis by 2 d and reduced infectious particle release. Furthermore, the co-expression of VP4 and VP3, but not their individual expression, recapitulated cell lysis in bacteria. Thus, SV40 regulates its life cycle by the later temporal expression of VP4, which results in cell lysis and enables the 50-nm virus to exit the cell. This study also demonstrates how viruses can generate multiple proteins with diverse functions and localizations from a single reading frame.

  19. Ikona Bogorodice s Djetetom iz crkve Sv. Nikole na Prijekom u Dubrovniku

    OpenAIRE

    Demori Staničić, Zoraida

    2013-01-01

    Ikona Bogorodice s Djetetom iz crkve sv. Nikole na Prijekom u Dubrovniku, nakon provedenog konzervatorsko-restauratorskog zahvata, na temelju stilske analize povezuje se s poznatom „Bogorodicom benediktinki“ iz Zadra i datira u isto vrijeme oko 1300. godine. Analizira se ikonografija ikone te otvara problem utjecaja slikarstva istočnog Mediterana na slikarstvo Dalmacije u XIII. stoljeću.

  20. Reply to Comments on Measuring marine iron(III) complexes by CLE-AdSV

    NARCIS (Netherlands)

    Town, R.M.; Leeuwen, van H.P.

    2005-01-01

    The interpretation of CLE-AdSV based iron(iii) speciation data for marine waters has been called into question in light of the kinetic features of the measurement. The implications of the re-think may have consequences for understanding iron biogeochemistry and its impact on ecosystem functioning.

  1. Reflection of P and SV waves from free surface of an elastic solid ...

    Indian Academy of Sciences (India)

    The reflection phenomena of P and SV waves from free surface of an elastic solid with thermodiffusion is considered. The boundary conditions are solved to obtain a system of four non- homogeneous equations for reflection coefficients. These reflection coefficients are found to depend upon the angle of incidence of P and ...

  2. SV3R : un framework pour la gestion de la variabilité des services

    Directory of Open Access Journals (Sweden)

    Boutaina Chakir

    2014-11-01

    Full Text Available The emergence and expansion of the development paradigm based on service-oriented approaches have been behind the elaboration of new models and methods that aim at facilitating the reuse of services within multiples context of use. This requires providing systematically services with several possible realizations. Among the promising approaches that achieve this objective is the management of variability which has been widely adopted by the software engineering disciplines and whose objective is to facilitate the adaptation or the configuration of software artifacts in a systematic way. Hence, in this work we provide a framework for the development (for and by reuse of services supporting variability, called “SV3R” (Service Variability Representation and Resolution for Reuse. This paper introduces at first the concept of variability. Afterwards, it presents some related work, before giving an overview of the framework SV3R and describing

  3. Validation of the portuguese version of the tampa scale for kinesiophobia heart (TSK-SV heart

    Directory of Open Access Journals (Sweden)

    Gabriela Lima de Melo Ghisi

    Full Text Available ABSTRACT Introduction: It has been shown that kinesiophobia has a negative influence on the outcomes of cardiac rehabilitation and consequently is important for the clinical setting. Objective: The objective of this study was to translate, culturally adapt, and psychometrically validate the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart to Brazilian Portuguese. Methods: The Portuguese version was tested in 300 patients in cardiac rehabilitation. Test-retest reliability was assessed by intraclass correlation coefficient, internal consistency by Cronbach’s alpha, and criterion validity was assessed with respect to patients’ education, income, duration of cardiac rehabilitation, and sex. Results: After intraclass correlation coefficient analysis, one item was excluded. All four areas were considered internally consistent (α >0.7. Significant differences between mean total scores and income (p 37. Conclusions: The Brazilian Portuguese version of TSK-SV Heart demonstrated sufficient reliability, consistency and validity, supporting its use in future studies.

  4. In situ study of SV40 virus DNA in lytic infection by mild loosening of nucleoproteins.

    Science.gov (United States)

    Puvion-Dutilleul, F; Pedron, J; Lange, M

    1980-11-01

    We have studied SV40 (simian virus40) nucleoprotein in permissively infected monkey kidney cell cultures (CV1) by a procedure which does not require the isolation of the SV40 chromosomes. Treatment of the cells by a low ionic strenght medium containing Photo flo produces a mild loosening of nucleoproteins, and permits the in situ study in ultrathin sections of virus components and their relationships with host cell chromatin. RNP and DNP could be distinguished by uranyl-EDTA-lead staining (for RNP) and by DNase digestion. SV40 DNA was observed as circular molecules, either free or connected with either RNP fibrils or virus capsids. These three aspects were interpreted, respectively, as viral minichromosomes, transcription of virus genome and partially encapsidated virus DNA. During encapsidation a few virus particles appear to be bound to host chromatin. Many, if not all, seemingly mature viruses, singly or in small linear clusters, are also aligned on host chromatin. Some of these observations were corroborated by the Miller spreading technique. They are consistent with a role for the host cell chromatin in the production of nuclear viruses.

  5. Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity

    OpenAIRE

    Mahon, Matthew J.

    2011-01-01

    The Simian Virus large T antigen (SVLT) induces replication of plasmids bearing the SV40 origin of replication (SV40 ori) within mammalian cells. The internal ribosomal entry site (IRES) is an element that allows for the co-translation of proteins from one polycistronic mRNA. Through the combination of these elements, IRES-dependent co-expression of a protein of interest and the SVLT, either constitutive or regulated, on plasmids bearing the SV40 ori generates a positive feedback loop, result...

  6. Validity and reliability of the Brazilian version of Yale-Brown obsessive compulsive scale-shopping version (YBOCS-SV).

    Science.gov (United States)

    Leite, Priscilla Lourenço; Filomensky, Tatiana Zambrano; Black, Donald W; Silva, Adriana Cardoso

    2014-08-01

    The Yale-Brown Obsessive Compulsive Scale-Shopping Version (YBOCS-SV) is considered the gold standard in the assessment of shopping severity. It is designed to assess cognitions and behaviors relating to compulsive buying behavior. The present study aims to assess the validity of the Brazilian version of this scale. For the study, composed the sample 610 participants: 588 subjects of a general population and 22 compulsive buyers. Factorial analysis was performed to assess the relations and the correlation between the YBOCS-SV, the Compulsive Buying Scale (CBS), and Richmond Compulsive Buying Scale (RCBS), was assessed using Pearson coefficient, for study of convergent and divergent validity. Cronbach's alpha coefficients were used to assess internal consistency. The results show good to excellent psychometric parameters for the YBOCS-SV in its Brazilian version. With regard to correlations, the YBOCS-SV is inversely and proportionally correlated with CBS and the RCBS, indicating that the YBOCS-SV is an excellent instrument for screening compulsive buying. The YBOCS-SV presented high alpha coefficient of Cronbach's alpha (0.92), demonstrating good reliability. The Brazilian version of the YBOCS-SV is indicated to diagnose compulsive buying disorder, and likely use for the purposes intended in the Brazilian population. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands.

    Science.gov (United States)

    Mercier, Joël; Archen, Laurence; Bollu, Véronique; Carré, Stéphane; Evrard, Yves; Jnoff, Eric; Kenda, Benoît; Lallemand, Bénédicte; Michel, Philippe; Montel, Florian; Moureau, Florence; Price, Nathalie; Quesnel, Yannick; Sauvage, Xavier; Valade, Anne; Provins, Laurent

    2014-04-01

    The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non-acetamide lead compounds, UCB-A, UCB-H and UCB-J, the first single-digit nanomolar SV2A ligands with suitable properties for development as PET tracers. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen

    Directory of Open Access Journals (Sweden)

    Hee Young Kang

    2017-12-01

    Full Text Available Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1. It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts. Hepatocytes overexpressing HSD11B1 were obtained from livers of this porcine model and cultured in vitro. However, the primary hepatocytes were found to have a short life span or low proliferation rate. To overcome these problems, the SV40 large T antigen was transduced into primary HSD11B1-TG hepatocytes, and those cells were immortalized. Immortalized HSD11B1-TG hepatocytes showed restored morphology, more rapid proliferation rate, and more expression of HSD11B1 than primary hepatocytes. As well, these cells kept the hepatic characteristics such as gluconeogenic response to cortisone and increased expression of hepatic makers. The immortalized HSD11B1-TG hepatocytes may be useful for studying traits and potential therapeutic drugs for treatment of metabolic disorders induced by overexpression of HSD11B1.

  9. Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen.

    Science.gov (United States)

    Kang, Hee Young; Choi, Young-Kwon; Jeong, Yeon Ik; Choi, Kyung-Chul; Hyun, Sang-Hwan; Hwang, Woo-Suk; Jeung, Eui-Bae

    2017-12-05

    Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG) fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts. Hepatocytes overexpressing HSD11B1 were obtained from livers of this porcine model and cultured in vitro. However, the primary hepatocytes were found to have a short life span or low proliferation rate. To overcome these problems, the SV40 large T antigen was transduced into primary HSD11B1-TG hepatocytes, and those cells were immortalized. Immortalized HSD11B1-TG hepatocytes showed restored morphology, more rapid proliferation rate, and more expression of HSD11B1 than primary hepatocytes. As well, these cells kept the hepatic characteristics such as gluconeogenic response to cortisone and increased expression of hepatic makers. The immortalized HSD11B1-TG hepatocytes may be useful for studying traits and potential therapeutic drugs for treatment of metabolic disorders induced by overexpression of HSD11B1.

  10. RELJEFI S PRIKAZIMA HERAKLOVIH DJELA U CRKVI SV. KAJA U SOLINU

    OpenAIRE

    Jeličić-Radonić, Jasna

    2005-01-01

    U crkvi sv. Kaja u Solinu nalazi se rimski "sarkofag" s prikazom Heraklovih djela, izvorno isklesan u litici unutar male spilje. Spomenik u obliku sanduka u neposrednoj blizini zapadne salonitanske nekropole bio je presudan da se u dosadašnjoj literaturi protumači kao antički sarkofag. Budući da je podzemni potok izvirao u spilji, a voda se skupljala u kamenom recipijentu s Heraklovim reljefima, odakle je otjecala, autorica prepoznaje Heraklovo svetište u prirodi. Tradicija o posvećenoj vodi ...

  11. Reflection of P and SV waves at the free surface of a monoclinic ...

    Indian Academy of Sciences (India)

    R.Narasimhan(krishtel emaging)1461 1996 Oct 15 13:05:22

    d2/d3 = V/(ρc2 − U)=(ρc2 − Z)/V. (12). Therefore, ρc2 satisfies the quadratic equation ρ2c4 − (U + Z)ρc2 + (UZ − V 2)=0,. (13a) with solutions. 2ρc2(p2,p3)=(U + Z) ± [(U − Z)2 + 4V 2]1/2. (13b). The upper sign in equation (13b) is for qP waves and the lower sign is for qSV waves. Eliminating ρc2 from the two equations in (12),.

  12. CCD Photometry of Field RR Lyrae Stars. I. Period Changes of SV ERI and XX and

    Directory of Open Access Journals (Sweden)

    Jong-Myung Joo

    1996-06-01

    Full Text Available CCD time series photometry was performed for two Oosterhoff type II± field RR Lyrae stars, SV Eri and XX And, to construct light curves in B and V bands. The maximum light times from our observations were combined with those in the literature to construct phase shift diagrams, from which we determined the period change rates β. We obtained large positive period change rates for these stars, which are expected from current evolutionary models if these stars are evolving rapidly from blue to red toward the end of core helium burning phase.

  13. Data on Leptospira interrogans sv Pomona infection in Meat Workers in New Zealand

    Directory of Open Access Journals (Sweden)

    M. Pittavino

    2017-08-01

    A prospective cohort study was conducted in four sheep slaughtering abattoirs in New Zealand (NZ (Dreyfus et al., 2015 [1]. Sera were collected twice a year from 384 meat workers and tested by Microscopic Agglutination for Leptospira interrogans sv Pomona (Pomona infection, one of the most common Leptospira serovars in humans in NZ. This article provides an extended analysis of the data, illustrating the different steps of a multivariable (i.e. generalized linear model and especially a multivariate tool based on additive Bayesian networks (ABN modelling.

  14. Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations.

    Science.gov (United States)

    Luzum, Jasmine A; Theusch, Elizabeth; Taylor, Kent D; Wang, Ann; Sadee, Wolfgang; Binkley, Philip F; Krauss, Ronald M; Medina, Marisa W; Kitzmiller, Joseph P

    2015-07-01

    Our objective was to evaluate the associations of genetic variants affecting simvastatin (SV) and simvastatin acid (SVA) metabolism [the gene encoding cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)*22 and the gene encoding cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5)*3] and transport [the gene encoding solute carrier organic anion transporter family member 1B1 (SLCO1B1) T521C] with 12-hour plasma SV and SVA concentrations. The variants were genotyped, and the concentrations were quantified by high performance liquid chromatography-tandem mass spectrometry in 646 participants of the Cholesterol and Pharmacogenetics clinical trial of 40 mg/d SV for 6 weeks. The genetic variants were tested for association with 12-hour plasma SV, SVA, or the SVA/SV ratio using general linear models. CYP3A5*3 was not significantly associated with 12-hour plasma SV or SVA concentration. CYP3A4*1/*22 participants had 58% higher 12-hour plasma SV concentration compared with CYP3A4*1/*1 participants (P = 0.006). SLCO1B1 521T/C and 521C/C participants had 71% (P SVA compared with SLCO1B1 521T/T participants, respectively. CYP3A4 and SLCO1B1 genotypes combined categorized participants into low (1) SVA/SV ratio groups (P = 0.001). In conclusion, CYP3A4*22 and SLCO1B1 521C were significantly associated with increased 12-hour plasma SV and SVA concentrations, respectively. CYP3A5*3 was not significantly associated with 12-hour plasma SV or SVA concentrations. The combination of CYP3A4*22 and SLCO1B1 521C was significantly associated with SVA/SV ratio, which may translate into different clinical SV risk/benefit profiles.

  15. Estimating surface reflectance from Himawari-8/AHI reflectance channels Using 6SV

    Science.gov (United States)

    Lee, Kyeong-sang; Choi, Sungwon; Seo, Minji; Seong, Noh-hun; Han, Kyung-soo

    2017-04-01

    TOA (Top Of Atmospheric) reflectance observed by satellite is modified by the influence of atmosphere such as absorbing and scattering by molecular and gasses. Removing TOA reflectance attenuation which is caused by the atmospheric is essential. surface reflectance with compensated atmospheric effects used as important input data for land product such as Normalized Difference Vegetation Index (NDVI), Land Surface Albedo (LSA) and etc. In this study, we Second Simulation of a Satellite Signal in the Solar Spectrum Vector (6SV) Radiative Transfer Model (RTM) for atmospheric correction and estimating surface reflectance from Himawari-8/Advanced Himawari Imager (AHI) reflectance channels. 6SV has the advantage that it has high accuracy by performing the atmospheric correction by dividing the width of the satellite channel by 2.5 nm, but it is slow to use in the operation. So, we use LUT approach to reduce the computation time and avoid the intensive calculation required for retrieving surface reflectance. Estimated surface reflectance data were compared with PROBA-V S1 data to evaluate the accuracy. As a result Root Mean Square Error (RMSE) and bias were about 0.05 and -0.02. It is considered that this error is due to the difference of angle component and Spectral Response Function (SRF) of each channel.

  16. Aplikace svítivých diod v osvětlovací technice

    OpenAIRE

    Kolář, Pavel

    2010-01-01

    Bakalářská práce pojednává o základních principech LED zdrojů a jejich napájení, charakteristice těchto zdrojů ve vztahu k aplikaci ve svítidlech, dále pak o možnostech aplikace\\break v praxi a ekonomickému přínosu LED technologie. K tomuto tématu je čerpáno z převážně internetových zdrojů a to proto, že výrobci a distributoři osvětlovací techniky na bázi LED jako jsou například firmy Osram, Siteco, Philips, Bergquist, Cree, LEDfield a další poskytují na svých internetových stránkách dostateč...

  17. Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects

    Energy Technology Data Exchange (ETDEWEB)

    Goto, Masami; Ino, Kenji; Yano, Keiichi [University of Tokyo Hospital, Department of Radiological Technology, Bunkyo-ku, Tokyo (Japan); Abe, Osamu [Nihon University School of Medicine, Department of Radiology, Itabashi-ku, Tokyo (Japan); Aoki, Shigeki [Juntendo University, Department of Radiology, Bunkyo-ku, Tokyo (Japan); Hayashi, Naoto [University of Tokyo Hospital, Department of Computational Diagnostic Radiology and Preventive Medicine, Bunkyo-ku, Tokyo (Japan); Miyati, Tosiaki [Kanazawa University, Graduate School of Medical Science, Kanazawa (Japan); Takao, Hidemasa; Mori, Harushi; Kunimatsu, Akira; Ohtomo, Kuni [University of Tokyo Hospital, Department of Radiology and Department of Computational Diagnostic Radiology and Preventive Medicine, Bunkyo-ku, Tokyo (Japan); Iwatsubo, Takeshi [University of Tokyo, Department of Neuropathology, Bunkyo-ku, Tokyo (Japan); Yamashita, Fumio [Iwate Medical University, Department of Radiology, Yahaba, Iwate (Japan); Matsuda, Hiroshi [Integrative Brain Imaging Center National Center of Neurology and Psychiatry, Department of Nuclear Medicine, Kodaira, Tokyo (Japan); Collaboration: Japanese Alzheimer' s Disease Neuroimaging Initiative

    2013-07-15

    This study aimed to investigate whether the effect of scanner for cortex volumetry with atlas-based method is reduced using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) normalization compared with standard normalization. Three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects were obtained and evaluated for effect of scanner in cortex volumetry. 3D-T1WIs of the 21 subjects were obtained with five MRI systems. Imaging of each subject was performed on each of five different MRI scanners. We used the Voxel-Based Morphometry 8 tool implemented in Statistical Parametric Mapping 8 and WFU PickAtlas software (Talairach brain atlas theory). The following software default settings were used as bilateral region-of-interest labels: ''Frontal Lobe,'' ''Hippocampus,'' ''Occipital Lobe,'' ''Orbital Gyrus,'' ''Parietal Lobe,'' ''Putamen,'' and ''Temporal Lobe.'' Effect of scanner for cortex volumetry using the atlas-based method was reduced with DARTEL normalization compared with standard normalization in Frontal Lobe, Occipital Lobe, Orbital Gyrus, Putamen, and Temporal Lobe; was the same in Hippocampus and Parietal Lobe; and showed no increase with DARTEL normalization for any region of interest (ROI). DARTEL normalization reduces the effect of scanner, which is a major problem in multicenter studies. (orig.)

  18. Detection of time-varying structures by large deformation diffeomorphic metric mapping to aid reading of high-resolution CT images of the lung.

    Science.gov (United States)

    Sakamoto, Ryo; Mori, Susumu; Miller, Michael I; Okada, Tomohisa; Togashi, Kaori

    2014-01-01

    To evaluate the accuracy of advanced non-linear registration of serial lung Computed Tomography (CT) images using Large Deformation Diffeomorphic Metric Mapping (LDDMM). FIFTEEN CASES OF LUNG CANCER WITH SERIAL LUNG CT IMAGES (INTERVAL: 62.2±26.9 days) were used. After affine transformation, three dimensional, non-linear volume registration was conducted using LDDMM with or without cascading elasticity control. Registration accuracy was evaluated by measuring the displacement of landmarks placed on vessel bifurcations for each lung segment. Subtraction images and Jacobian color maps, calculated from the transformation matrix derived from image warping, were generated, which were used to evaluate time-course changes of the tumors. The average displacement of landmarks was 0.02±0.16 mm and 0.12±0.60 mm for proximal and distal landmarks after LDDMM transformation with cascading elasticity control, which was significantly smaller than 3.11±2.47 mm and 3.99±3.05 mm, respectively, after affine transformation. Emerged or vanished nodules were visualized on subtraction images, and enlarging or shrinking nodules were displayed on Jacobian maps enabled by highly accurate registration of the nodules using LDDMM. However, some residual misalignments were observed, even with non-linear transformation when substantial changes existed between the image pairs. LDDMM provides accurate registration of serial lung CT images, and temporal subtraction images with Jacobian maps help radiologists to find changes in pulmonary nodules.

  19. Quantization and analysis of hippocampal morphometric changes due to dementia of Alzheimer type using metric distances based on large deformation diffeomorphic metric mapping.

    Science.gov (United States)

    Ceyhan, Elvan; Beg, Mirza Faisal; Ceritoglu, Can; Wang, Lei; Morris, John C; Csernansky, John G; Miller, Michael I; Ratnanather, J Tilak

    2011-06-01

    The metric distance obtained from the large deformation diffeomorphic metric mapping (LDDMM) algorithm is used to quantize changes in morphometry of brain structures due to neuropsychiatric diseases. For illustrative purposes we consider changes in hippocampal morphometry (shape and size) due to very mild dementia of the Alzheimer type (DAT). LDDMM, which was previously used to calculate dense one-to-one correspondence vector fields between hippocampal shapes, measures the morphometric differences with respect to a template hippocampus by assigning metric distances on the space of anatomical images thereby allowing for direct comparison of morphometric differences. We characterize what information the metric distances provide in terms of size and shape given the hippocampal, brain and intracranial volumes. We demonstrate that metric distance is a measure of morphometry (i.e., shape and size) but mostly a measure of shape, while volume is mostly a measure of size. Moreover, we show how metric distances can be used in cross-sectional, longitudinal analysis, as well as left-right asymmetry comparisons, and provide how the metric distances can serve as a discriminative tool using logistic regression. Thus, we show that metric distances with respect to a template computed via LDDMM can be a powerful tool in detecting differences in shape. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects.

    Science.gov (United States)

    Goto, Masami; Abe, Osamu; Aoki, Shigeki; Hayashi, Naoto; Miyati, Tosiaki; Takao, Hidemasa; Iwatsubo, Takeshi; Yamashita, Fumio; Matsuda, Hiroshi; Mori, Harushi; Kunimatsu, Akira; Ino, Kenji; Yano, Keiichi; Ohtomo, Kuni

    2013-07-01

    This study aimed to investigate whether the effect of scanner for cortex volumetry with atlas-based method is reduced using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) normalization compared with standard normalization. Three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects were obtained and evaluated for effect of scanner in cortex volumetry. 3D-T1WIs of the 21 subjects were obtained with five MRI systems. Imaging of each subject was performed on each of five different MRI scanners. We used the Voxel-Based Morphometry 8 tool implemented in Statistical Parametric Mapping 8 and WFU PickAtlas software (Talairach brain atlas theory). The following software default settings were used as bilateral region-of-interest labels: "Frontal Lobe," "Hippocampus," "Occipital Lobe," "Orbital Gyrus," "Parietal Lobe," "Putamen," and "Temporal Lobe." Effect of scanner for cortex volumetry using the atlas-based method was reduced with DARTEL normalization compared with standard normalization in Frontal Lobe, Occipital Lobe, Orbital Gyrus, Putamen, and Temporal Lobe; was the same in Hippocampus and Parietal Lobe; and showed no increase with DARTEL normalization for any region of interest (ROI). DARTEL normalization reduces the effect of scanner, which is a major problem in multicenter studies.

  1. Epilepsy caused by an abnormal alternative splicing with dosage effect of the SV2A gene in a chicken model.

    Directory of Open Access Journals (Sweden)

    Marine Douaud

    Full Text Available Photosensitive reflex epilepsy is caused by the combination of an individual's enhanced sensitivity with relevant light stimuli, such as stroboscopic lights or video games. This is the most common reflex epilepsy in humans; it is characterized by the photoparoxysmal response, which is an abnormal electroencephalographic reaction, and seizures triggered by intermittent light stimulation. Here, by using genetic mapping, sequencing and functional analyses, we report that a mutation in the acceptor site of the second intron of SV2A (the gene encoding synaptic vesicle glycoprotein 2A is causing photosensitive reflex epilepsy in a unique vertebrate model, the Fepi chicken strain, a spontaneous model where the neurological disorder is inherited as an autosomal recessive mutation. This mutation causes an aberrant splicing event and significantly reduces the level of SV2A mRNA in homozygous carriers. Levetiracetam, a second generation antiepileptic drug, is known to bind SV2A, and SV2A knock-out mice develop seizures soon after birth and usually die within three weeks. The Fepi chicken survives to adulthood and responds to levetiracetam, suggesting that the low-level expression of SV2A in these animals is sufficient to allow survival, but does not protect against seizures. Thus, the Fepi chicken model shows that the role of the SV2A pathway in the brain is conserved between birds and mammals, in spite of a large phylogenetic distance. The Fepi model appears particularly useful for further studies of physiopathology of reflex epilepsy, in comparison with induced models of epilepsy in rodents. Consequently, SV2A is a very attractive candidate gene for analysis in the context of both mono- and polygenic generalized epilepsies in humans.

  2. Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity.

    Science.gov (United States)

    Mahon, Matthew J

    2011-08-01

    The simian virus 40 large T antigen (SVLT) induces replication of plasmids bearing the SV40 origin of replication (SV40 ori) within mammalian cells. The internal ribosomal entry site (IRES) is an element that allows for the cotranslation of proteins from one polycistronic mRNA. Through the combination of these elements, IRES-dependent coexpression of a protein of interest and the SVLT, either constitutive or regulated, on plasmids bearing the SV40 ori generates a positive feedback loop, resulting in enhanced expression. A vector linking red fluorescent protein (RFP) to the IRES-SVLT element enhances fluorescence ~10-fold over that demonstrated from a vector lacking this element. In transfection-resistant CV-1 cells, the RFP-IRES-SVLT vector substantially increases the number of cells expressing detectable levels of RFP. Furthermore, inclusion of the IRES-SVLT/SV40 ori elements in standard luciferase-based reporter gene constructs and associated effectors results in marked increases in luminescent output and sensitivity, using the β-catenin/TCF pathway and the mammalian two-hybrid assay as models. Ultimately, vector systems combining these well-established elements (IRES-SVLT/SV40 ori) will increase the utility of transient transfection for the production of recombinant proteins, the use of transfection-resistant cell lines, and the effectiveness of luciferase-based high-throughput screening assays.

  3. Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts

    Directory of Open Access Journals (Sweden)

    Easton Marilyn J

    2010-02-01

    Full Text Available Abstract Background Simian Virus 40 (SV40 immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however gene-level interactions between 3-MC and SV40 that could have produced the observed tumors have not been explored. The commercially-available human uroepithelial cell lines were either SV40-immortalized (HUC or SV40-immortalized and then 3-MC-transformed (HUC-TC. Results To characterize the SV40 - 3MC interaction, we compared human gene expression in these cell lines using a human cancer array and confirmed selected changes by RT-PCR. Many viral Large T Antigen (Tag expression-related changes occurred in HUC-TC, and it is concluded that SV40 and 3-MC may act synergistically to transform cells. Changes noted in IFP 9-27, 2'-5' OAS, IF 56, MxA and MxAB were typical of those that occur in response to viral exposure and are part of the innate immune response. Because interferon is crucial to innate immune host defenses and many gene changes were interferon-related, we explored cellular growth responses to exogenous IFN-γ and found that treatment impeded growth in tumor, but not immortalized HUC on days 4 - 7. Cellular metabolism however, was inhibited in both cell types. We conclude that IFN-γ metabolic responses were functional in both cell lines, but IFN-γ anti-proliferative responses functioned only in tumor cells. Conclusions Synergism of SV40 with 3-MC or other environmental carcinogens may be of concern as SV40 is now endemic in 2-5.9% of the U.S. population. In addition, SV40-immortalization is a generally-accepted method used in many research materials, but the possibility of off-target effects in studies carried out using these cells has not been considered. We hope that our work will stimulate further study of this important phenomenon.

  4. Age-related changes in the motricity of the inbred mice strains 129/sv and C57BL/6j.

    Science.gov (United States)

    Serradj, Najet; Jamon, Marc

    2007-02-12

    The development of motor skills was studied at different stages in the life of the mouse, focusing on three key aspects of motor development: early rhythmic motor activities prior to the acquisition of quadruped locomotion, motor skills in young adults, and the effect of aging on motor skills. The age-related development pattern was analysed and compared in two strains of major importance for genomic studies (C57Bl6/j and 129/sv). Early rhythmic air-stepping activities by l-dopa injected mice showed similar overall development in both strains; differences were observed with greater beating frequency and less inter-limb coordination in 129/sv, suggesting that 129/sv had a different maturation process. Performance on the rotarod by young adult C57Bl6/j gradually improved between 1 and 3 months, but then declined with age; performance on the treadmill also declined with an age-related increase in fatigability. Overall performance by 129/sv mice was lower than C57Bl6/j, and the age-related pattern of change was different, with 129/sv having relatively stable performance over time. Inter-strain differences and their possible causes, in particular the role of dopaminergic pathways, are discussed together with repercussions affecting mutant phenotyping procedures.

  5. The adaptation of limb kinematics to increasing walking speeds in freely moving mice 129/Sv and C57BL/6.

    Science.gov (United States)

    Serradj, Nadjet; Jamon, Marc

    2009-07-19

    The kinematics of locomotion was analyzed in two strains of great importance for the creation of mutated mice (C56BL/6 and 129/Sv). Different behavioral situations were used to trigger sequences of movement covering the whole range of velocities in the mice, and the variations of kinematic parameters were analyzed in relation with velocity. Both stride frequency and stride length contributed to the moving speed, but stride frequency was found to be the main contributor to the speed increase. A trot-gallop transition was detected at speed about 70 cm/s, in relation with a sharp shift in limb coordination. The results of this study were consistent with pieces of information previously published concerning the gait analyses of other strains, and provided an integrative view of the basic motor pattern of mice. On the other hand some qualitative differences were found in the movement characteristics of the two strains. The stride frequency showed a higher contribution to speed in 129/Sv than in C57BL/6. In addition, 129/Sv showed a phase shift in the forelimb and hindlimb, and a different position of the foot during the stance time that revealed a different gait and body position during walking. Overall, 129/Sv moved at a slower speed than C57BL/6 in any behavioral situation. This difference was related to a basal lower level of motor activity. The possibility that an alteration in the dopamine circuit was responsible for the different movement pattern in 129/Sv is discussed.

  6. Cytopathic effect of Human cosavirus (HCoSV) on primary cell cultures of human embryonic lung MRC5.

    Science.gov (United States)

    Rezig, Dorra; Touzi, Henda; Meddeb, Zina; Triki, Henda

    2014-10-01

    Human cosaviruses (HCoSVs) are newly discovered viruses in Picornaviridae family. Until now, most published studies reported HCoSV detection using molecular techniques and genetic characterization of the virus. Nevertheless, no laboratory has yet reported the replication of these viruses in cultured cell lines. In the present work, the propagation of HCoSV strains isolated from human fecal specimens in MRC5 cell line and their induced cytopathic effects (CPE) was studied. The first sign of virus growth was observed 24-48h after inoculation. The cells rounded up and clumped together rapidly; empty areas became visible and, on the third day of CPE, a remarkable decrease in live cells was observed. This represents the first report on in vitro model of HCoSV replication which opens up opportunities for future investigations of these new viruses. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.

    Directory of Open Access Journals (Sweden)

    Joanna Lee

    Full Text Available The putative Major Facilitator Superfamily (MFS transporter, SV2A, is the target for levetiracetam (LEV, which is a successful anti-epileptic drug. Furthermore, SV2A knock out mice display a severe seizure phenotype and die after a few weeks. Despite this, the mode of action of LEV is not known at the molecular level. It would be extremely desirable to understand this more fully in order to aid the design of improved anti-epileptic compounds. Since there is no structure for SV2A, homology modelling can provide insight into the ligand-binding site. However, it is not a trivial process to build such models, since SV2A has low sequence identity to those MFS transporters whose structures are known. A further level of complexity is added by the fact that it is not known which conformational state of the receptor LEV binds to, as multiple conformational states have been inferred by tomography and ligand binding assays or indeed, if binding is exclusive to a single state. Here, we explore models of both the inward and outward facing conformational states of SV2A (according to the alternating access mechanism for MFS transporters. We use a sequence conservation analysis to help guide the homology modelling process and generate the models, which we assess further with Molecular Dynamics (MD. By comparing the MD results in conjunction with docking and simulation of a LEV-analogue used in radioligand binding assays, we were able to suggest further residues that line the binding pocket. These were confirmed experimentally. In particular, mutation of D670 leads to a complete loss of binding. The results shed light on the way LEV analogues may interact with SV2A and may help with the on-going design of improved anti-epileptic compounds.

  8. A generic framework for modeling brain deformation as a constrained parametric optimization problem to aid non-diffeomorphic image registration in brain tumor imaging.

    Science.gov (United States)

    Mang, A; Toma, A; Schuetz, T A; Becker, S; Buzug, T M

    2012-01-01

    In the present paper a novel computational framework for modeling tumor induced brain deformation as a biophysical prior for non-rigid image registration is described. More precisely, we aim at providing a generic building block for non-rigid image registration that can be used to resolve inherent irregularities in non-diffeomorphic registration problems that naturally arise in serial and cross-population brain tumor imaging studies due to the presence (or progression) of pathology. The model for the description of brain cancer dynamics on a tissue level is based on an initial boundary value problem (IBVP). The IBVP follows the accepted assumption that the progression of primary brain tumors on a tissue level is governed by proliferation and migration of cancerous cells into surrounding healthy tissue. The model of tumor induced brain deformation is phrased as a parametric, constrained optimization problem. As a basis of comparison and to demonstrate generalizability additional soft constraints (penalties) are considered. A back-tracking line search is implemented in conjunction with a limited memory Broyden-Fletcher-Goldfarb-Shanno (LBFGS) method in order to handle the numerically delicate log-barrier strategy for confining volume change. Numerical experiments are performed to test the flexible control of the computed deformation patterns in terms of varying model parameters. The results are qualitatively and quantitatively related to patterns in patient individual magnetic resonance imaging data. Numerical experiments demonstrate the flexible control of the computed deformation patterns. This in turn strongly suggests that the model can be adapted to patient individual imaging patterns of brain tumors. Qualitative and quantitative comparison of the computed cancer profiles to patterns in medical imaging data of an exemplary patient demonstrates plausibility. The designed optimization problem is based on computational tools widely used in non-rigid image

  9. Discovery and development of SV2A PET tracers: Potential for imaging synaptic density and clinical applications.

    Science.gov (United States)

    Mercier, Joel; Provins, Laurent; Valade, Anne

    2017-11-01

    Imaging synaptic density in vivo has promise for numerous research and clinical applications in the diagnosis and treatment monitoring of neurodegenerative and psychiatric diseases. Recent developments in the field of PET, such as SV2A human imaging with the novel tracers UCB-A, UCB-H and UCB-J, may help in realizing this potential and bring significant benefit for the patients suffering from these diseases. This review provides an overview of the most recent progress in the field of SV2A PET imaging, its potential for use as a biomarker of synaptic density and the future development areas. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants

    Energy Technology Data Exchange (ETDEWEB)

    Kawano, Masaaki [Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Morikawa, Katsuma [Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501 (Japan); Suda, Tatsuya [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Ohno, Naohito [Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Matsushita, Sho [Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Allergy Center, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Akatsuka, Toshitaka [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Handa, Hiroshi, E-mail: handa.h.aa@m.titech.ac.jp [Solutions Research Laboratory, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8503 (Japan); Matsui, Masanori, E-mail: mmatsui@saitama-med.ac.jp [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan)

    2014-01-05

    Virus-like particles (VLPs) are a promising vaccine platform due to the safety and efficiency. However, it is still unclear whether polyomavirus-based VLPs are useful for this purpose. Here, we attempted to evaluate the potential of polyomavirus VLPs for the antiviral vaccine using simian virus 40 (SV40). We constructed chimeric SV40-VLPs carrying an HLA-A{sup ⁎}02:01-restricted, cytotoxic T lymphocyte (CTL) epitope derived from influenza A virus. HLA-A{sup ⁎}02:01-transgenic mice were then immunized with the chimeric SV40-VLPs. The chimeric SV40-VLPs effectively induced influenza-specific CTLs and heterosubtypic protection against influenza A viruses without the need of adjuvants. Because DNase I treatment of the chimeric SV40-VLPs did not disrupt CTL induction, the intrinsic adjuvant property may not result from DNA contaminants in the VLP preparation. In addition, immunization with the chimeric SV40-VLPs generated long-lasting memory CTLs. We here propose that the chimeric SV40-VLPs harboring an epitope may be a promising CTL-based vaccine platform with self-adjuvant properties. - Highlights: • We constructed chimeric SV40-VLPs carrying an influenza virus-derived CTL epitope. • Chimeric SV40-VLPs induce influenza-specific CTLs in mice without adjuvants. • Chimeric SV40-VLPs induce heterosubtypic protection against influenza A viruses. • Chimeric SV40-VLPs induce long-lasting memory CTLs. • Chimeric SV40-VLPs is a promising vaccine platform with self-adjuvant properties.

  11. Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies

    Directory of Open Access Journals (Sweden)

    Miguel G. Toscano

    2017-09-01

    Full Text Available Replication-defective (RD recombinant simian virus 40 (SV40-based gene delivery vectors hold a great potential for clinical applications because of their presumed non-immunogenicity and capacity to induce immune tolerance to the transgene products in humans. However, the clinical use of SV40 vectors has been hampered by the lack of a packaging cell line that produces replication-competent (RC free SV40 particles in the vector production process. To solve this problem, we have adapted the current SV40 vector genome used for the production of vector particles and generated a novel Vero-based packaging cell line named SuperVero that exclusively expresses the SV40 large T antigen. SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the absence of contaminating RC SV40 particles. Our unique SV40 vector platform named SVac paves the way to clinically test a whole new generation of SV40-based therapeutics for a broad range of important diseases.

  12. Use of 2sv-technology for thermal utilisation of biomass according to biomass regulation; Einsatz der 2sv-Technologie zur thermischen Verwertung von Biomasse gemaess der Biomasseverordnung

    Energy Technology Data Exchange (ETDEWEB)

    Nitsche, R. [Mitteldeutsche Feuerungs- und Umwelttechnik GmbH, Leipzig (Germany); Mallon, J. [Ingitec GmbH, Leipzig (Germany); Scheidig, K.

    2001-07-01

    The 2sv-procedure represents an economic alternative to energetic utilisation of biomass and to thermal utilisation of waste. Core piece of the new plant technology is the 2sv-reactor. The speciality of the process is the melting gasification of the used materials with technical oxygen. The metallurgic process technology that is well-known and proved from shaft furnaces is used and thus temperatures of up to 2000 degrees Celsius are reached in a reducing atmosphere. The generated fuel gas has the characteristics of synthesis gas. It is not only suitable for electric current generation in dual purpose power plants but also for the substitution of primary energy carriers in furnace plants. The company MFU GmbH Leipzig-Holzhausen delivers 2vs-plants in modular design for processing capacities of 10, 20 and 30 kt/a. (orig.) [German] Das 2sv-Verfahren stellt eine wirtschaftliche Alternative zur energetischen Nutzung von Biomassen wie auch zur thermischen Abfallverwertung dar. Herzstueck der neuen Anlagentechnik ist der 2sv-Reaktor. Die Besonderheiten des Prozesses bestehen in der Schmelzvergasung der Einsatzstoffe unter Einsatz von technischem Sauerstoff. Unter Nutzung der vom Schachtofen bekannten und bewaehrten metallurgischen Verfahrenstechnik werden dabei Temperaturen bis 2000 C in reduzierender Atmosphaere erreicht. Das erzeugte Brenngas besitzt Synthesegasqualitaet. Es ist sowohl zur Stromerzeugung im BHKW als auch zur Substitution von Primaerenergietraegern in Feuerungsanlagen geeignet. Die MFU GmbH Leipzig-Holzhausen liefert komplette 2sv-Anlagen in Modulbauweise fuer Verarbeitungskapazitaeten von 10, 30 und 50 kt/a. (orig.)

  13. One-mSv CT colonography: Effect of different iterative reconstruction algorithms on radiologists' performance.

    Science.gov (United States)

    Shin, Cheong-Il; Kim, Se Hyung; Im, Jong Pil; Kim, Sang Gyun; Yu, Mi Hye; Lee, Eun Sun; Han, Joon Koo

    2016-03-01

    To analyze the effect of different reconstruction algorithms on image noise and radiologists' performance at ultra-low dose CT colonography (CTC) in human subjects. This retrospective study had institutional review board approval, with waiver of the need to obtain informed consent. CTC and subsequent colonoscopy were performed at the same day in 28 patients. CTC was scanned at the supine/prone positions using 120/100kVp and fixed 10mAs, and reconstructed using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), and model-based IR (Veo) algorithms. Size-specific dose estimates (SSDE) and effective radiation doses were recorded. Image noise was compared among the three datasets using repeated measures analysis of variance (ANOVA). Per-polyp sensitivity and figure-of-merits were compared among the datasets using the McNemar test and jackknife alternative free-response receiver operating characteristic (JAFROC) analysis, respectively, by one novice and one expert reviewer in CTC. Mean SSDE and effective radiation dose of CTC were 1.732mGy and 1.002mSv, respectively. Mean image noise at supine/prone position datasets was significantly lowest with Veo (17.2/13.3), followed by ASIR (52.4/38.9) and FBP (69.9/50.8) (Preconstruction (81.0%, 64.3%), followed by ASIR (73.8%, 54.8%) and FBP (57.1%, 50.0%) with statistical significance between Veo and FBP for reader 1 (P=0.002). JAFROC analysis revealed that the figure-of-merit for the detection of polyps was highest with Veo (0.917, 0.786), followed by ASIR (0.881, 0.750) and FBP (0.750, 0.746) with statistical significances between Veo or ASIR and FBP for reader 1 (P<0.05). One-mSv CTC was not feasible using the standard FBP algorithm. However, diagnostic performance expressed as per-polyp sensitivity and figures-of-merit can be improved with the application of IR algorithms, particularly Veo. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Zhuji; Chen, Chen; Barbieri, Joseph T.; Kim, Jung-Ja P.; Baldwin, Michael R.; (MCW)

    2010-02-22

    Botulinum neurotoxin causes rapid flaccid paralysis through the inhibition of acetylcholine release at the neuromuscular junction. The seven BoNT serotypes (A-G) have been proposed to bind motor neurons via ganglioside-protein dual receptors. To date, the structure-function properties of BoNT/F host receptor interactions have not been resolved. Here, we report the crystal structures of the receptor binding domains (HCR) of BoNT/A and BoNT/F and the characterization of the dual receptors for BoNT/F. The overall polypeptide fold of HCR/A is essentially identical to the receptor binding domain of the BoNT/A holotoxin, and the structure of HCR/F is very similar to that of HCR/A, except for two regions implicated in neuronal binding. Solid phase array analysis identified two HCR/F binding glycans: ganglioside GD1a and oligosaccharides containing an N-acetyllactosamine core. Using affinity chromatography, HCR/F bound native synaptic vesicle glycoproteins as part of a protein complex. Deglycosylation of glycoproteins using {alpha}(1-3,4)-fucosidase, endo-{beta}-galactosidase, and PNGase F disrupted the interaction with HCR/F, while the binding of HCR/B to its cognate receptor, synaptotagmin I, was unaffected. These data indicate that the HCR/F binds synaptic vesicle glycoproteins through the keratan sulfate moiety of SV2. The interaction of HCR/F with gangliosides was also investigated. HCR/F bound specifically to gangliosides that contain {alpha}2,3-linked sialic acid on the terminal galactose of a neutral saccharide core (binding order GT1b = GD1a GM3; no binding to GD1b and GM1a). Mutations within the putative ganglioside binding pocket of HCR/F decreased binding to gangliosides, synaptic vesicle protein complexes, and primary rat hippocampal neurons. Thus, BoNT/F neuronal discrimination involves the recognition of ganglioside and protein (glycosylated SV2) carbohydrate moieties, providing a structural basis for the high affinity and specificity of BoNT/F for neurons.

  15. Sigma Virus (DMelSV Incidence in Lines of Drosophila melanogaster Selected for Survival following Infection with Bacillus cereus

    Directory of Open Access Journals (Sweden)

    Meghan L. Bentz

    2017-01-01

    Full Text Available The immune response of Drosophila melanogaster is complex and involves both specific and general responses to parasites. In this study we tested for cross-immunity for bacteria and viruses by scoring the incidence of infection with the vertically transmitted Sigma virus (DMelSV in the progeny of a cross between females transmitting DMelSV at high frequencies and males from lines subjected to three selection regimes related to resistance to Bacillus cereus. There was no significant difference in transmission of DMelSV among selection regimes, though results suggest that the B. cereus selected lines had lower rates of infection by DMelSV. We found a significant difference in viral infection with respect to the sex of the progeny, with males consistently less likely to be infected than females. Given a finite energy budget, flies that have experienced immune system challenge may show alterations in other life history traits. Later eclosing progeny were also less likely to be infected than earlier eclosing progeny, indicating a relationship with development time. Finally, there was a significant interaction between the timing of collection and the sex of the progeny, such that later eclosing males were the most resistant group. Increased development time is sometimes associated with increased energy acquisition; from this perspective, increased development time may be associated with acquiring sufficient resources for effective resistance.

  16. Identification of potential drug targets in Salmonella enterica sv. Typhimurium using metabolic modelling and experimental validation

    DEFF Research Database (Denmark)

    Hartman, Hassan B.; Fell, David A.; Rossell, Sergio

    2014-01-01

    Salmonella enterica sv. Typhimurium is an established model organism for Gram-negative, intracellular pathogens. Owing to the rapid spread of resistance to antibiotics among this group of pathogens, new approaches to identify suitable target proteins are required. Based on the genome sequence of ...

  17. Musikterapi med børn med svær autisme - en litteraturgennemgang

    Directory of Open Access Journals (Sweden)

    Ulla Holck

    2003-03-01

    Full Text Available Faglitteratur om musikterapi med børn med autisme er omfattende og indeholder såvel kvalitative case-beskrivelser som kvantitative forskningsundersøgelser. I artiklen gennemgås faglitteraturen systematisk med henblik på at specifi cere musikterapiens effekt og virkemåder i forhold til denne målgruppe. Vægten ligger på børn med svær autisme, men litteratur om voksne højtfungerende personer med autisme inddrages også. Forskningslitteraturen viser, at det især er inden for områderne koncentration, visuel opmærksomhed, respons og initiativ, samt brug af stemme og tur-tagning, at musikterapi har en effekt. Case-litteraturen begrunder denne effekt med musikkens evne til at være redundant, anvendelse af imitation og responsfremmende teknikker (overraskelse etc., fælles opbyggede samspilsformer, samt det temporale-interaktive element i improvisatorisk musikterapi. Ud fra en interaktionsteoretisk indfaldsvinkel sammenkobles effekten endvidere med, at den musikalske interaktion hjælper musikterapeuten til at fastholde et dynamisk udtryk, hvilket er afgørende i forhold til en klientgruppe, der ofte giver ´flad´ eller stærkt afvigende feedback.

  18. A human corneal equivalent constructed from SV40-immortalised corneal cell lines.

    Science.gov (United States)

    Zorn-Kruppa, Michaela; Tykhonova, Svitlana; Belge, Gazanfer; Bednarz, Jürgen; Diehl, Horst A; Engelke, Maria

    2005-02-01

    Within the last decade, extensive research in the field of tissue and organ engineering has focused on the development of in vitro models of the cornea. The use of organotypic, three-dimensional corneal equivalents has several advantages over simple monolayer cultures. The aim of this study was to develop a corneal equivalent model composed of the same cell types as in the natural human tissue, but by using immortalised cell lines to ensure reproducibility and to minimise product variation. We report our success in the establishment of an SV40-immortalised human corneal keratocyte cell line (designated HCK). A collagen matrix, built up with these cells, displayed the morphological characteristics of the human stromal tissue and served as a biomatrix for the immortalised human corneal epithelial and endothelial cells. Histological cross-sections of the whole-cornea equivalents resemble human corneas in tissue structure. This organotypic in vitro model may serve as a research tool for the ophthalmic science community, as well as a model system for testing for eye irritancy and drug efficacy.

  19. SV40-transformed human corneal keratocytes: optimisation of serum-free culture conditions.

    Science.gov (United States)

    Manzer, Anna Katharina; Lombardi-Borgia, Simone; Schäfer-Korting, Monika; Seeber, Judith; Zorn-Kruppa, Michaela; Engelke, Maria

    2009-01-01

    Aiming at the replacement of animal experiments in eye irritation testing, we have established a multilay ered cornea model comprising the co-culture of all three corneal cell types. It was the objective of this study to optimise serum-free culture conditions to preserve both growth and phenotype of an SV40-immortalised human corneal keratocyte cell line (HCK). Our results revealed that HCK continue to proliferate in both monolayer cultures as well as after seeding in a collagen matrix and resemble primary corneal keratocytes in morphology and functional characteristics under defined serum-free conditions. Furthermore, HCK were shown to transform into activated corneal fibroblast phenotypes in response to serum and TGF(beta)1. In summary, HCK cells mimic their in vivo (primary) precursors, both in sustaining the quiescent keratocyte phenotype (serum-starved conditions) and in responding to growth factor stimulation. Hence, this cell line may provide a useful tool to study the toxicity and wound healing response of corneal keratocytes in vitro.

  20. DYNAMIC INFLUENCE CAUSED BY CLOSE BLASTING ON PRIMARY AND SECONDARY SUPPORT SYSTEM IN TUNNEL "SV. ROK"

    Directory of Open Access Journals (Sweden)

    Zvonimir Ester

    2003-12-01

    Full Text Available At the construction site of the road tunnel Sv. Rok, the second, left tunnels tube is being constructed parallel to the unfinished right tunnel. The part of right tunnel tube is supported with primary support system according to NAMT, the second part is supported complete with concrete. Distance between axes of the tunnel tubes is approximately 35 m. Drifting of the left tube is being done by blasting. A potential problem of damaging the surrounding rock and support system was recognized. It is well known that the ground vibration particle velocity due to a blast is a measure of damage on the nearby construction. The three component seismographs were used to measure ground oscillation velocities in the right tunnel tube. Total of 30 measurements were executed and 720 values were processed (including all three component oscillation velocities. Maximum ground oscillation velocity recorded was 232.061 mm/s. This paper brings conclusion derived from monitoring data achieved at close proximity to the blasting area, damage level criteria for the rock mass and support system and discusses how these results could assist further development in the control of blasting technique.

  1. Abrogation of p53-mediated transactivation by SV40 large T antigen.

    Science.gov (United States)

    Segawa, K; Minowa, A; Sugasawa, K; Takano, T; Hanaoka, F

    1993-03-01

    p53 is known to bind specifically to the 44-bp human DNA sequence in an immunoprecipitation assay. We show here that the transcription of the reporter CAT gene linked with the herpesvirus thymidine kinase (tk) promoter containing the 44-base sequence is enhanced by mouse wild-type but not mutant-type p53 in F9 and p53-null Saos-2 cells. The p53-mediated transactivation was dramatically abrogated by introduction of SV40 large T antigen (SVLT) in Saos-2 cells in which p53 was clearly associated with SVLT. Furthermore, the p53-SVLT complex did not bind to the 44-base sequence at all. Thus, SVLT sequesters the transactivation function of the wild-type p53 by inhibiting the binding of p53 to the 44-base sequence. This is good evidence to show 'loss of functions' in the product of a tumor-suppressor oncogene by a dominant oncogene product at a molecular level.

  2. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Science.gov (United States)

    Sowd, Gregory A; Mody, Dviti; Eggold, Joshua; Cortez, David; Friedman, Katherine L; Fanning, Ellen

    2014-12-01

    Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs) kinase activity, facilitates some aspects of double strand break (DSB) repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR) and do not colocalize with non-homologous end joining (NHEJ) factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs) and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  3. SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication Products

    Science.gov (United States)

    Sowd, Gregory A.; Mody, Dviti; Eggold, Joshua; Cortez, David; Friedman, Katherine L.; Fanning, Ellen

    2014-01-01

    Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PKcs kinase activity, facilitates some aspects of double strand break (DSB) repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR) and do not colocalize with non-homologous end joining (NHEJ) factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PKcs and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5′ to 3′ end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication. PMID:25474690

  4. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Directory of Open Access Journals (Sweden)

    Gregory A Sowd

    2014-12-01

    Full Text Available Simian virus 40 (SV40 and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs kinase activity, facilitates some aspects of double strand break (DSB repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR and do not colocalize with non-homologous end joining (NHEJ factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  5. Replication of pSV2-gpt in COS-1 cells: stability of plasmid DNA in the presence and absence of biochemical selection.

    Science.gov (United States)

    Tsui, L C; Breitman, M L

    1985-03-01

    We have previously demonstrated that COS-1 cell lines transformed by pSV2-gpt and maintained under biochemical selection replicate multiple copies of extrachromosomal plasmid DNA (1). We have now examined the replication and stability of this DNA in a representative cell line. In situ hybridization analyses revealed that intense replication of pSV2-gpt occurs in only a small subpopulation of cells and results from bursts of plasmid replication that occur periodically and spontaneously in the cell population. This suggests that COS-1 cells are only semipermissive for pSV2-gpt replication. No correlation was observed between levels of pSV2-gpt replication and the presence or absence of biochemical selection for the Gpt marker. However, growth of cells under nonselective conditions led to a rapid and progressive loss of pSV2-gpt DNA. This loss correlated with segregation of Gpt- revertants that lacked detectable plasmid sequences. Hence, maintenance of pSV2-gpt in the cell line was dependent on continuous biochemical selection. Stable replication of pSV2-gpt could be observed as late as four months after transfection, suggesting that this system might be useful for propagation of cloned DNA in COS-1 cells for extended periods of time. However, by nine months, extensive rearrangements of pSV2-gpt sequences were detected, indicating ultimate instability of the plasmid in the host cells.

  6. Definition and evolution of a new symbiovar, sv. rigiduloides, among Ensifer meliloti efficiently nodulating Medicago species.

    Science.gov (United States)

    Gubry-Rangin, Cécile; Béna, Gilles; Cleyet-Marel, Jean-Claude; Brunel, Brigitte

    2013-10-01

    Understanding functional diversity is one of the main goals of microbial ecology, and definition of new bacterial ecotypes contributes significantly to this objective. Nitrogen-fixing bacteria provide a good system for investigation of ecotypes/biovars/symbiovars, as they present different specific associations with several host plants. This specific symbiosis is reflected both in the nodulation and fixation efficiency and in genetic characters of the bacteria, and several biovars have already been described in the bacterial species Ensifer meliloti. In the present study, the species affiliation of E. meliloti strains trapped from nodules sampled from Medicago rigiduloïdes roots was analyzed using housekeeping recA genes and DNA-DNA hybridization. The genetic diversity of these isolates was also investigated using several symbiotic markers: nodulation (nodA, nodB, nodC) and nitrogen fixation (nifH) genes, as well as the performance of phenotypic tests of nodulation capacity and nitrogen fixation efficiency. These analyses led to the proposal of a new bacterial symbiovar, E. meliloti sv. rigiduloides, that fixed nitrogen efficiently on M. rigiduloïdes, but not on Medicago truncatula. Using phylogenetic reconstructions, including the different described symbiovars, several hypotheses of lateral gene transfer and gene loss are proposed to explain the emergence of symbiovars within this species. The widespread geographical distribution of this symbiovar around the Mediterranean Basin, in contrast to restriction of M. rigiduloïdes to Eastern European countries, suggests that these isolates might also be associated with other plant species. The description of a new symbiovar within E. meliloti confirms the need for accurate bacterial ecological classification, especially for analysis of bacterial populations. Copyright © 2013 Elsevier GmbH. All rights reserved.

  7. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik

    Når det er svært at være ung i DK – viden og råd om unges trivsel og mistrivsel er afslutningen på et større forskningsprojekt om unges trivsel og mistrivsel. Hæftet præsenterer forskningsprojektets hovedkonklusioner og giver desuden en række råd og ideer til, hvordan voksne kan hjælpe unge med...... at håndtere mistrivsel. Hæftet er udarbejdet af forskerne Jens Christian Nielsen og Niels Ulrik Sørensen fra Center for Ungdomsforskning. Det er den sidste publikation i forskningsprojektet Når det er svært at være ung i DK, der fra 2008-2011 har belyst unges trivsel og mistrivsel. Projektet bygger både på en...

  8. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Grubb, Ane

    I rapporten Når det er svært at være ung i DK – unges beretninger om mistrivsel og ungdomsliv præsenteres resultaterne af et kvalitativt studie af mistrivsel og ungdomsliv blandt 15-24-årige unge i Danmark. Studiet bygger på dybdegående interviews med 33 unge fra forskellige dele af landet, der...... fortæller om deres erfaringer med diverse mistrivselsformer, som ensomhed, selvskadende adfærd og mobning, og om deres besvær med at håndtere de krav, udfordringer og muligheder, der i øvrigt præger det moderne ungdomsliv. Studiet indgår i det treårige forskningsprojekt Når det er svært at være ung i DK...

  9. MOĆI SV. IVANA – TROGIRSKI PALADIJ ZALOŽEN U ZADRU (FILIGRAN U RIZNICAMA DALMATINSKIH KATEDRALA)

    OpenAIRE

    Belamarić, Joško

    2000-01-01

    Koncem 14. stoljeća Trogirani bijahu prisiljeni založiti moćnik ruke svog zaštitnika u Zadar. Već 1399. odlučuju se ne samo otkupiti svoj moćnik i restaurirati ga, nego po izvornoj ruci naručiti novu u zadarskog zlatara Emerika Krenjića, koju on zbog smrti u lipnju 1400. nije dovršio. Izvorna ruka sv. Ivana Trogirskoga, koju je trebao kopirati, bila je remek-djelo mletačkog zlatarstva iz 1270-ih godina. Daju se i novi prijedlozi za datiranje filigrana na moćnicima ruku i glave sv. Vlaha u Dub...

  10. Konstrukce genderové identity v seriálu Dokonalý svět

    OpenAIRE

    Mlynářová, Martina

    2014-01-01

    The thesis analyzes the instruments of gender stereotypes reproduction and gender identity construction in Czech TV series Dokonalý svět. Is the media content gendered? With which instruments of gender stereotypes reproduction and gender identity construction is TV viewer confronted and on which levels? I use the theory of social construction of reality, the theory of the lenses of gender or the characters and narrative structure of the TV series (soup opera) to come to a conclusion. The thes...

  11. Attempts on producing lymphoid cell line from Penaeus monodon by induction with SV40-T and 12S EIA oncogenes.

    Science.gov (United States)

    Puthumana, Jayesh; Prabhakaran, Priyaja; Philip, Rosamma; Singh, I S Bright

    2015-12-01

    In an attempt of in vitro transformation, transfection mediated expression of Simian virus-40 (T) antigen (SV40-T) and transduction mediated expression of Adenovirus type 12 early region 1A (12S E1A) oncogene were performed in Penaeus monodon lymphoid cells. pSV3-neo vector encoding SV40-T oncogene and a recombinant baculovirus BacP2-12S E1A-GFP encoding 12S E1A oncogene under the control of hybrid promoters were used. Electroporation and lipofection mediated transformation of SV40-T in lymphoid cells confirmed the transgene expression by phenotypic variation and the expression of GFP in co-transfection experiment. The cells transfected by lipofection (≥ 5%) survived for 14 days with lower toxicity (30%), whilst on electroporation, most of the cells succumbed to death (60%) and survived cells lived up to 7 days. Transduction efficiency in primary lymphoid cells was more than 80% within 14 days of post-transduction, however, an incubation period of 7 days post-transduction was observed without detectable expression of 12S E1A. High level of oncogenic 12S E1A expression were observed after 14 day post-transduction and the proliferating cells survived for more than 90 days with GFP expression, however, without in vitro transformation and immortalization. The study put forth the requirement of transduction mediated 'specific' oncogene expression along with telomerase activation and epigenetic induction for the immortalization and establishment of shrimp cell line. Copyright © 2015. Published by Elsevier Ltd.

  12. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

    det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

  13. Branching ratios, CP asymmetries and polarizations of B → ψ(2S)V decays

    Energy Technology Data Exchange (ETDEWEB)

    Rui, Zhou [North China University of Science and Technology, College of Sciences, Tangshan (China); Li, Ya; Xiao, Zhen-Jun [Nanjing Normal University, Department of Physics and Institute of Theoretical Physics, Nanjing, Jiangsu (China)

    2017-09-15

    We analyze the non-leptonic decays B/B{sub s} → ψ(2S)V with V = (ρ, ω, K*, φ) by employing the perturbative QCD (pQCD) factorization approach. Here the branching ratios, the CP asymmetries and the complete set of polarization observables are investigated systematically. Besides the traditional contributions from the factorizable and non-factorizable diagrams at the leading order, the next-to-leading order (NLO) vertex corrections could also provide considerable contributions. The pQCD predictions for the branching ratios of the B{sub (s)} → ψ(2S)K*, ψ(2S)φ decays are consistent with the measured values within errors. As for B → ψ(2S)ρ, ψ(2S)ω decays, the branching ratios can reach the order of 10{sup -5} and could be measured in the LHCb and Belle-II experiments. The numerical results show that the direct CP asymmetries of the considered decays are very small. Thus the observation of any large direct CP asymmetry for these decays will be a signal for new physics. The mixing-induced CP asymmetries in the neutral modes are very close to sin 2β{sub (s)}, which suggests that these channels can give a cross-check on the measurement of the Cabbibo-Kobayashi-Maskawa (CKM) angle β and β{sub s}. We find that the longitudinal polarization fractions f{sub 0} are suppressed to ∝ 50% due to the large non-factorizable contributions. The magnitudes and phases of the two transverse amplitudes A {sub parallel} and A {sub perpendicular} {sub to} are roughly equal, which is an indication for the approximate light-quark helicity conservation in these decays. The overall polarization observables of B → ψ(2S)K{sup *0} and B{sub s} → ψ(2S)φ channels are also in good agreement with the experimental measurements as reported by LHCb and BaBar. Other results can also be tested by the LHCb and Belle-II experiments. (orig.)

  14. Subcellular localization of SV2 and other secretory vesicle components in PC12 cells by an efficient method of preembedding EM immunocytochemistry for cell cultures

    DEFF Research Database (Denmark)

    Tanner, V A; Ploug, Thorkil; Tao-Cheng, J H

    1996-01-01

    substantially improved the efficiency of the preembedding EM ICC procedures for cell cultures. The advantages and related caveats of this method are discussed. SV2 was distinctly localized on dusters of synaptic vesicles and large dense-cored vesicles (LDCV). The distribution of SV2 on these two types...... membranes. Furthermore, whereas SV2 is localized on the membranes of the LDCVs, chromogranin A, an acidic protein in secretory granules, is clearly in the core of the LDCVs. This is the first demonstration of these two antigens in such dose (approximately 20 nm) yet distinct compartments within a single...

  15. Effects of Enrichment and Litter Parity on Reproductive Performance and Behavior in BALB/c and 129/Sv Mice

    Science.gov (United States)

    Whitaker, Julia W; Moy, Sheryl S; Pritchett-Corning, Kathleen R; Fletcher, Craig A

    2016-01-01

    We examined the effect of adding species-appropriate environmental enrichment items to breeding cages of BALB/cAnNCrl and 129S2/SvPasCrl mice. The 3 enrichment conditions were: 1) cotton nesting material; 2) nesting material plus a paper shelter and rolled paper bedding; and 3) an igloo dome with an exercise wheel in addition to the shelter-group enrichments. We measured litter size, litter survival to weaning age, average pup weight at 21 d, and the interlitter interval to evaluate reproductive performance. A random subset of the first- or second-litter offspring from each enrichment condition and strain was assessed in multiple behavioral tests. Enrichment significantly affected anxiety-like behavior and sociability, with the direction of change dependent on strain and sex. Litter parity had greater effects on some reproductive parameters than did the enrichment condition, and this effect was not solely due to a difference between the first compared with subsequent litters. The significant effects of litter parity on the number of pups born and weaned, female pup weight, and interlitter interval were dependent on the enrichment condition in BALB/c but not 129/Sv mice. Offspring from the first or second litter were included in a generational component to investigate whether enrichment effects on reproduction persist in adult offspring after transfer to a different facility for breeding. Natal cage enrichment had no effect on any reproductive parameter in the transferred mice. Overall, additional enrichment beyond nesting material had a beneficial effect on the interlitter interval in BALB/c mice and on the number of pups weaned in 129/Sv mice. PMID:27423144

  16. Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation

    OpenAIRE

    Cheng-Wei Chang; Chaang-Ray Chen; Chao-Ying Huang; Wun-Yi Shu; Chi-Shiun Chiang; Ji-Hong Hong; Hsu, Ian C.

    2013-01-01

    Simian virus 40 (SV40) transforms cells through the suppression of tumor-suppressive responses by large T and small t antigens; studies on the effects of these two oncoproteins have greatly improved our knowledge of tumorigenesis. Large T antigen promotes cellular transformation by binding and inactivating p53 and pRb tumor suppressor proteins. Previous studies have shown that not all of the tumor-suppressive responses were inactivated in SV40-transformed cells; however, the underlying cause ...

  17. Determination of radon and radium concentrations in drinking water samples around the city of Kutahya.

    Science.gov (United States)

    Sahin, Latife; Cetinkaya, Hakan; Murat Saç, Müslim; Içhedef, Mutlu

    2013-08-01

    The concentration of radium and radon has been determined in drinking water samples collected from various locations of Kutahya city, Turkey. The water samples are taken from public water sources and tap water, with the collector chamber method used to measure the radon and radium concentration. The radon concentration ranges between 0.1 and 48.6±1.7 Bq l(-1), while the radium concentration varies from a minimum detectable activity of water, humidity, pressure, elevation and the coordinates of the sampling points have also been measured and recorded. The annual effective dose from radon and radium due to typical water usage has been calculated. The resulting contribution to the annual effective dose due to radon ingestion varies between 0.3 and 124.2 μSv y(-1); the contribution to the annual effective dose due to radium ingestion varies between 0 and 143.3 μSv y(-1); the dose contribution to the stomach due to radon ingestion varies between 0.03 and 14.9 μSv y(-1). The dose contribution due to radon inhalation ranges between 0.3 and 122.5 μSv y(-1), assuming a typical transfer of radon in water to the air. For the overwhelming majority of the Kutahya population, it is determined that the average radiation exposure from drinking water is less than 73.6 µSv y(-1).

  18. Analysis of uranium concentration in drinking water samples using ICPMS.

    Science.gov (United States)

    Rani, Asha; Mehra, Rohit; Duggal, Vikas; Balaram, V

    2013-03-01

    Uranium concentration in drinking water samples collected from some areas of Northern Rajasthan has been measured using inductively coupled plasma mass spectrometry. The water samples were taken from hand pumps. The uranium concentration in water samples varies from 2.54-133.0 μg L with a mean value of 38.48 μg L. The uranium concentration in most of the drinking water samples exceeds the safe limit (30 μg L) recommended by the World Health Organization. The annual effective dose associated with drinking water due to uranium concentration is estimated from its annual intake using dosimetric information based on ICRP 72. The resulting value of the annual effective dose from drinking water sources is in the range of 2.11-110.45 μSv. The annual effective dose in one of the samples was found to be greater than WHO-recommended level of 100 μSv y.

  19. Numerical Study on Dynamic Response of a Horizontal Layered-Structure Rock Slope under a Normally Incident Sv Wave

    Directory of Open Access Journals (Sweden)

    Zhifa Zhan

    2017-07-01

    Full Text Available Several post-earthquake investigations have indicated that the slope structure plays a leading role in the stability of rock slopes under dynamic loads. In this paper, the dynamic response of a horizontal layered-structure rock slope under harmonic Sv wave is studied by making use of the Fast Lagrangian Analysis of Continua method (FLAC. The suitability of FLAC for studying wave transmission across rock joints is validated through comparison with analytical solutions. After parametric studies on Sv wave transmission across the horizontal layered-structure rock slope, it is found that the acceleration amplification coefficient η, which is defined as the ratio of the acceleration at the monitoring point to the value at the toe, wavily increases with an increase of the height along the slope surface. Meanwhile, the fluctuation weakens with normalized joint stiffness K increasing and enhances with normalized joint spacing ξ increasing. The acceleration amplification coefficient of the slope crest ηcrest does not monotonously increase with the increase of ξ, but decreases with the increase of K. Additionally, ηcrest is more sensitive to ξ compared to K. From the contour figures, it can also be found that the contour figures of η take on rhythm, and the effects of ξ on the acceleration amplification coefficient are more obvious compared to the effects on K.

  20. Olipski fragment gotičkoga srebrnog ophodnog križa s prikazom Sv. Stošije

    Directory of Open Access Journals (Sweden)

    Marijana Kovačević

    2013-12-01

    Full Text Available U župnom uredu u Olibu prije nekoliko je godina pronađen zanimljiv srebrni fragment s prikazom svetice. Slijedom usporedbe sa srodnim liturgijskim predmetima utvrđuje se da je riječ o fragmentu ophodnoga križa s prikazom svetice zaštitnice olipske župe, sv. Stošije, koji je nekada bio pričvršćen u središtu njegova reversa, te se određuje njegova datacija u konac 14. st. Ikonografska je identifikacija prikazanoga lika, osim logikom mjesta nalaza, učvršćena i ikonografskom analizom prikaza sv. Stošije u romaničkoj i gotičkoj umjetnosti na području Zadra nastalih tijekom toga višestoljetnoga razdoblja, napose u zlatarstvu, te je na taj način utvrđen i svojevrstan evolutivni pomak u prikazivanju svetice koja je ujedno i zaštitnica Zadarske nadbiskupije.

  1. The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA.

    Science.gov (United States)

    Gai, Dahai; Wang, Damian; Li, Shu-Xing; Chen, Xiaojiang S

    2016-12-06

    DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How these hexameric helicases interact with their origin dsDNA remains unknown. Here, we report the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin dsDNA. The structure shows that the six subunits form a near-planar ring that interacts with the origin, so that each subunit makes unique contacts with the DNA. The origin dsDNA inside the narrower AAA+ domain channel shows partial melting due to the compression of the two phosphate backbones, forcing Watson-Crick base-pairs within the duplex to flip outward. This structure provides the first snapshot of a hexameric helicase binding to origin dsDNA, and suggests a possible mechanism of origin melting by LT during SV40 replication in eukaryotic cells.

  2. Dedicated sub 0.1 mSv 3DCT using MBIR in children with suspected craniosynostosis: quality assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, Caroline W.; Hulstaert, Tine L.; Belsack, Dries; Buls, Nico; Gompel, Gert van; Nieboer, Koenraad H.; Verhelle, Filip; Maeseneer, Michel de; Mey, Johan de [Universitair Ziekenhuis Brussel, Department of Radiology, Brussels (Belgium); Buyl, Ronald [Vrije Universiteit Brussel, Department of Biomedical Statistics and Informatics, Brussels (Belgium)

    2016-03-15

    To retrospectively compare image quality of a lowered dose CT protocol to a standard CT protocol in children with suspicion of craniosynostosis. Forty-eight patients (age 0- 35 months), who presented with a cranial deformity underwent cranial 3D CT to assess sutural patency: between 2009 - 2010, 24 patients were imaged with a standard protocol (CTDIvol 32.18 mGy), from 2011-2012, 24 underwent a low dose protocol (0.94 mGy) combined with iterative reconstruction. Image quality was evaluated by both expert reading and objective analysis. Differences were assessed by independent t-test and Mann-Whitney U test, interreader agreement by Cohen's Kappa test. Effective dose of the low dose protocol was 0.08 mSv, corresponding to a reduction of 97 %. Image quality was similar in both groups in terms of overall diagnostic acceptability, objective noise measurements, subjective cranial bone edge sharpness and presence of artefacts. For objective sharpness of cranial bone-brain interface and subjective perception of noise, the images of the low dose protocol were superior. For all evaluated structures, interreader agreement was moderate to almost perfect. In the diagnosis of craniosynostosis in children with cranial deformities, a dedicated sub 0.1 mSv cranial 3DCT protocol can be used without loss in image quality. (orig.)

  3. Postmoderní obraz světa podle Petera Sloterdijka

    OpenAIRE

    Vodička, Bohumil

    2014-01-01

    7 The abstract I consider the works of Peter Sloterdijk in my thesis. I concentrate to Sloterdijk's way of understanding of the topic cynicism in the relationship to kynicism. At first I try to describe the topic cynicism which I consider as very important to understand Sloterdijk's way of understanding of the European history in the book Falls Europa erwacht. I try to explain, how the cynicism influences various parts of life, I consider particularly the military cynicism and the cynicism of...

  4. Application of SV40 T-transformed human corneal epithelial cells to evaluate potential irritant chemicals for in vitro alternative eye toxicity.

    Science.gov (United States)

    Kim, Cho-Won; Park, Geon-Tae; Bae, Ok-Nam; Noh, Minsoo; Choi, Kyung-Chul

    2016-01-01

    Assessment of eye irritation potential is important to human safety, and it is necessary for various cosmetics and chemicals that may contact the human eye. Until recently, the Draize test was considered the standard method for estimating eye irritation, despite its disadvantages such as the need to sacrifice many rabbits for subjective scoring. Thus, we investigated the cytotoxicity and inflammatory response to standard eye irritants using SV40 T-transformed human corneal epithelial (SHCE) cells as a step toward development of an animal-free alternative eye irritation test. MTT and NRU assays of cell viability were performed to investigate the optimal experimental conditions for SHCE cell viability when cells were exposed to sodium dodecyl sulfate (SDS) as a standard eye irritant at 6.25×10(-3) to 1×10(-1)%. Additionally, cell viability of SHCE cells was examined in response to six potential eye irritants, benzalkonium chloride, dimethyl sulfoxide, isopropanol, SDS, Triton X-100 and Tween 20 at 5×10(-3) to 1×10(-1)%. Finally, we estimated the secretion level of cytokines in response to stimulation by eye irritants in SHCE cells. SHCE cells showed a good response to potential eye irritants when the cells were exposed to potential irritants for 10min at room temperature (RT), and cytokine production increased in a concentration-dependent manner, indicating that cytotoxicity and cytokine secretion from SHCE cells may be well correlated with the concentrations of irritants. Taken together, these results suggest that SHCE cells could be an excellent alternative in vitro model to replace in vivo animal models for eye irritation tests. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. LOXL3-sv2, a novel variant of human lysyl oxidase-like 3 (LOXL3), functions as an amine oxidase.

    Science.gov (United States)

    Jeong, Chankyu; Kim, Youngho

    2017-03-01

    Human lysyl oxidase-like 3 (LOXL3) functions as a copper-dependent amine oxidase toward collagen and elastin. The LOXL3 protein contains four scavenger receptor cysteine-rich (SRCR) domains in the N-terminus in addition to the C-terminal characteristic domains of the lysyl oxidase (LOX) family, such as a copper-binding domain, a cytokine receptor‑like domain and residues for the lysyl-tyrosyl quinone cofactor. Using BLASTN searches, we identified a novel variant of LOXL3 (termed LOXL3-sv2), which lacked the sequences corresponding to exons 4 and 5 of LOXL3. The LOXL3-sv2 mRNA is at least 2,398 bp in length, encoding a 608 amino acid-long polypeptide with a calculated molecular mass of 67.4 kDa. The deletion of exons 4 and 5 do not change the open-reading frame of LOXL3 but results in deletion of the SRCR domain 2. The recombinant LOXL3-sv2 protein showed a β-aminopropionitrile-inhibitable amine oxidase activity toward collagen type I. In RT-PCR analysis, LOXL3-sv2 was detected in all human tissues tested, along with LOXL3 and LOXL3-sv1, a previously identified variant of LOXL3. These findings indicate that the human LOXL3 gene encodes at least three variants, LOXL3, LOXL3-sv1 and LOXL3-sv2, all of which function as amine oxidases.

  6. Sjælden immundefekt bag svær atopisk dermatitis i barnealderen

    DEFF Research Database (Denmark)

    Wolsk, Helene Mygind; Marquart, Hanne V; Laub, Bodil

    2015-01-01

    Two children are presented with autosomal recessive hyper IgE syndrome caused by a mutation in the dedicator of cytokinesis 8 gene (DOCK8). The manifestations are typically severe atopic dermatitis, food allergies, elevated serum IgE concentration, viral skin infections and risk of malignancies....... DOCK8 deficiency was first reported in 2009, following the death of the oldest sibling. The youngest sibling was cured after allogenic stem cell transplantation. This case report illustrates the need of awareness of primary immunodeficiency in children with atypical manifestation of atopic dermatitis...

  7. Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice

    Science.gov (United States)

    Wu, Ruirui; Wu, Xiafang; Wang, Huihui; Fang, Xin; Li, Yongfang; Gao, Lanyue; Sun, Guifan; Pi, Jingbo; Xu, Yuanyuan

    2017-03-01

    Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility and metabolism. Mouse strain variability may provide a better understanding of the arsenic pathological profile but is largely unknown. Here we investigated oxidative lesion induced by acute arsenic exposure in the two frequently used mouse strains C57BL/6J and 129X1/SvJ in classical gene targeting technique. A dose of 5 mg/kg body weight arsenic led to a significant alteration of blood glutathione towards oxidized redox potential and increased hepatic malondialdehyde content in C57BL/6J mice, but not in 129X1/SvJ mice. Hepatic antioxidant enzymes were induced by arsenic in transcription in both strains and many were higher in C57BL/6J than 129X1/SvJ mice. Arsenic profiles in the liver, blood and urine and transcription of genes encoding enzymes involved in arsenic biomethylation all indicate a higher arsenic methylation capacity, which contributes to a faster hepatic arsenic excretion, in 129X1/SvJ mice than C57BL/6J mice. Taken together, C57BL/6J mice are more susceptible to oxidative hepatic injury compared with 129X1/SvJ mice after acute arsenic exposure, which is closely associated with arsenic methylation pattern of the two strains.

  8. Comparative transcriptome profiling of an SV40-transformed human fibroblast (MRC5CVI and its untransformed counterpart (MRC-5 in response to UVB irradiation.

    Directory of Open Access Journals (Sweden)

    Cheng-Wei Chang

    Full Text Available Simian virus 40 (SV40 transforms cells through the suppression of tumor-suppressive responses by large T and small t antigens; studies on the effects of these two oncoproteins have greatly improved our knowledge of tumorigenesis. Large T antigen promotes cellular transformation by binding and inactivating p53 and pRb tumor suppressor proteins. Previous studies have shown that not all of the tumor-suppressive responses were inactivated in SV40-transformed cells; however, the underlying cause is not fully studied. In this study, we investigated the UVB-responsive transcriptome of an SV40-transformed fibroblast (MRC5CVI and that of its untransformed counterpart (MRC-5. We found that, in response to UVB irradiation, MRC-5 and MRC5CVI commonly up-regulated the expression of oxidative phosphorylation genes. MRC-5 up-regulated the expressions of chromosome condensation, DNA repair, cell cycle arrest, and apoptotic genes, but MRC5CVI did not. Further cell death assays indicated that MRC5CVI was more sensitive than MRC-5 to UVB-induced cell death with increased caspase-3 activation; combining with the transcriptomic results suggested that MRC5CVI may undergo UVB-induced cell death through mechanisms other than transcriptional regulation. Our study provides a further understanding of the effects of SV40 transformation on cellular stress responses, and emphasizes the value of SV40-transformed cells in the researches of sensitizing neoplastic cells to radiations.

  9. Equilibrium Investment Strategy for DC Pension Plan with Inflation and Stochastic Income under Heston’s SV Model

    Directory of Open Access Journals (Sweden)

    Jingyun Sun

    2016-01-01

    Full Text Available We consider a portfolio selection problem for a defined contribution (DC pension plan under the mean-variance criteria. We take into account the inflation risk and assume that the salary income process of the pension plan member is stochastic. Furthermore, the financial market consists of a risk-free asset, an inflation-linked bond, and a risky asset with Heston’s stochastic volatility (SV. Under the framework of game theory, we derive two extended Hamilton-Jacobi-Bellman (HJB equations systems and give the corresponding verification theorems in both the periods of accumulation and distribution of the DC pension plan. The explicit expressions of the equilibrium investment strategies, corresponding equilibrium value functions, and the efficient frontiers are also obtained. Finally, some numerical simulations and sensitivity analysis are presented to verify our theoretical results.

  10. Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose

    DEFF Research Database (Denmark)

    Øvrehus, Kristian Altern; Schuhbaeck, Annika; Marwan, Mohamed

    2015-01-01

    or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment...... using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility.......6% and +/- 32.1%, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc...

  11. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA in cultured cells.

    Directory of Open Access Journals (Sweden)

    Benjamin Macadangdang

    Full Text Available Peptide nucleic acid (PNA is known to bind with extraordinarily high affinity and sequence-specificity to complementary nucleic acid sequences and can be used to suppress gene expression. However, effective delivery into cells is a major obstacle to the development of PNA for gene therapy applications. Here, we present a novel method for the in vitro delivery of antigene PNA to cells. By using a nucleocapsid protein derived from Simian virus 40, we have been able to package PNA into pseudovirions, facilitating the delivery of the packaged PNA into cells. We demonstrate that this system can be used effectively to suppress gene expression associated with multidrug resistance in cancer cells, as shown by RT-PCR, flow cytometry, Western blotting, and cell viability under chemotherapy. The combination of PNA with the SV40-based delivery system is a method for suppressing a gene of interest that could be broadly applied to numerous targets.

  12. Diversity of methane-producing microbial community structure with 16S-V3 rDNA PCR-DGGE

    Directory of Open Access Journals (Sweden)

    Na Wang

    2016-01-01

    Full Text Available The method of 16S-V3 rDNA PCR-DGGE was utilized to study the diversity of methane-producing microbial community structure under different methane-producing microbial community structure. Results showed that community structure of the methanogens under different environmental condition was significantly different. The number of bands about community under extreme condition was less than normal conditions, but the main bands were obvious. The sequence analysis showed that the predominant strains mainly were uncultured bacteria that could not be identified in the level of species .Z2 was Clostridia, Z8 was Clostridiales, D5 was Eubacteriaceae, and D8 was Flavobacteriaceae. This study laid some extent foundation for future research about establishing a methane-producing bacterial system with high gas yield in winter.

  13. Napájecí zdroj pro kyslíkovodíkovou svářečku

    OpenAIRE

    Kalus, Jiří

    2016-01-01

    Diplomová práce se zabývá problematikou návrhu napájecího zdroje elektrolyzéru pro plynovou svářečku na bázi vodíku a kyslíku. Hlavní náplní práce je návrh tohoto zdroje, který bude realizován jako spínaný. Což vede k menším rozměrům a hmotnosti. Práce obsahuje návrh DPS a naměřené parametry zdroje. Master´s thesis deals with design of oxy-hydrogen generator power supply for gas welder. Main topic of this thesis is a design of switching mode power supply, which leads to smaller dimensions ...

  14. Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40.

    Science.gov (United States)

    Raptis, L; Brownell, H L; Corbley, M J; Wood, K W; Wang, D; Haliotis, T

    1997-08-01

    To investigate the role of the cellular ras gene product in neoplastic transformation by the SV40 large tumor antigen (SVLT), murine C3H10T1/2 cells were rendered deficient in Ras activity by transfection with inducible or constitutive antisense ras gene constructs or through the introduction of the dominant-negative mutant, ras(asn17). Consistent with previous results, SVLT-induced morphological transformation was unaffected by the down-regulation of c-ras gene product activity. On the other hand, colony formation in soft agar and tumorigenicity in nude mice were drastically reduced in c-Ras-deficient cells. In addition, SVLT expression in C3H10T1/2 cells led to increased c-Ras activity, as determined by an increase in the Ras-bound GTP/GTP + GDP ratio. These results suggest that c-Ras is required for full neoplastic transformation by SVLT.

  15. DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc.

    Science.gov (United States)

    Kim, Yun Chul; Kitaura, Hirotake; Iguchi-Ariga, Sanae M M; Ariga, Hiroyoshi

    2010-09-24

    Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation. Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  16. Maestro di Pico i iluminacije u inkunabuli De Civitate Dei (Nicolas Jenson, Venecija, 1475.) u samostanu Sv. Duje u Kraju na Pašmanu

    OpenAIRE

    Goja, Bojan

    2014-01-01

    U franjevačkom samostanu Sv. Duje u Kraju na otoku Pašmanu čuva se inkunabula „O državi Božjoj“ (De Civitate Dei) Sv. Aurelija Augustina koju je 1475. godine u Veneciji tiskao Nicolas Jenson. Inkunabula je na f. 17 (kako je naknadno označena paginacija grafitnom olovkom, tj. stranici incipita – liber primus) kao i na više drugih stranica ukrašena lijepim višebojnim iluminacijama renesansnih stilskih karakteristika izrađenih temperom, zlatnim listićima, zlatnim prahom, sepijom, tintom i akvare...

  17. Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis.

    Science.gov (United States)

    Yoshiura, Takashi; Hiwatashi, Akio; Yamashita, Koji; Ohyagi, Yasumasa; Monji, Akira; Takayama, Yukihisa; Kamano, Norihiro; Kawashima, Toshiro; Kira, Jun-Ichi; Honda, Hiroshi

    2011-02-01

    To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia. MR images of 37 consecutive patients including 19 with Alzheimer's disease (AD) and 18 with amnestic mild cognitive impairment (aMCI) were retrospectively analyzed. All patients were administered the CPM. Regional grey matter (GM) volume was evaluated according to the regimens of voxel-based morphometry, during which a non-linear registration algorithm called Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra was employed. Multiple regression analyses were used to map the regions where GM volumes were correlated with CPM scores. The strongest correlation with CPM scores was seen in the left middle frontal gyrus while a region with the largest volume was identified in the left superior temporal gyrus. Significant correlations were seen in 14 additional regions in the bilateral cerebral hemispheres and right cerebellum. Deterioration of abstract reasoning ability in AD and aMCI measured by CPM is related to GM loss in multiple regions, which is in close agreement with the results of previous activation studies.

  18. The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets

    Directory of Open Access Journals (Sweden)

    Porwollik Steffen

    2011-10-01

    Full Text Available Abstract Background The Ferric uptake regulator (Fur is a transcriptional regulator that controls iron homeostasis in bacteria. Although the regulatory role of Fur in Escherichia coli is well characterized, most of the studies were conducted under routine culture conditions, i.e., in ambient oxygen concentration. To reveal potentially novel aspects of the Fur regulon in Salmonella enterica serovar Typhimurium under oxygen conditions similar to that encountered in the host, we compared the transcriptional profiles of the virulent wild-type strain (ATCC 14028s and its isogenic Δfur strain under anaerobic conditions. Results Microarray analysis of anaerobically grown Δfur S. Typhimurium identified 298 differentially expressed genes. Expression of several genes controlled by Fnr and NsrR appeared to be also dependent on Fur. Furthermore, Fur was required for the activity of the cytoplasmic superoxide disumutases (MnSOD and FeSOD. The regulation of FeSOD gene, sodB, occurred via small RNAs (i.e., the ryhB homologs, rfrA and rfrB with the aid of the RNA chaperone Hfq. The transcription of sodA was increased in Δfur; however, the enzyme was inactive due to the incorporation of iron instead of manganese in SodA. Additionally, in Δfur, the expression of the gene coding for the ferritin-like protein (ftnB was down-regulated, while the transcription of the gene coding for the nitric oxide (NO· detoxifying flavohemoglobin (hmpA was up-regulated. The promoters of ftnB and hmpA do not contain recognized Fur binding motifs, which indicated their probable indirect regulation by Fur. However, Fur activation of ftnB was independent of Fnr. In addition, the expression of the gene coding for the histone-like protein, H-NS (hns was increased in Δfur. This may explain the observed down-regulation of the tdc operon, responsible for the anaerobic degradation of threonine, and ftnB in Δfur. Conclusions This study determined that Fur is a positive factor in ftn

  19. Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium

    Directory of Open Access Journals (Sweden)

    Porwollik Steffen

    2011-03-01

    Full Text Available Abstract Background Salmonella enterica serovar Typhimurium (S. Typhimurium is a Gram-negative pathogen that must successfully adapt to the broad fluctuations in the concentration of dissolved dioxygen encountered in the host. In Escherichia coli, ArcA (Aerobic Respiratory Control helps the cells to sense and respond to the presence of dioxygen. The global role of ArcA in E. coli is well characterized; however, little is known about its role in anaerobically grown S. Typhimurium. Results We compared the transcriptional profiles of the virulent wild-type (WT strain (ATCC 14028s and its isogenic arcA mutant grown under anaerobic conditions. We found that ArcA directly or indirectly regulates 392 genes (8.5% of the genome; of these, 138 genes are poorly characterized. Regulation by ArcA in S. Typhimurium is similar, but distinct from that in E. coli. Thus, genes/operons involved in core metabolic pathways (e.g., succinyl-CoA, fatty acid degradation, cytochrome oxidase complexes, flagellar biosynthesis, motility, and chemotaxis were regulated similarly in the two organisms. However, genes/operons present in both organisms, but regulated differently by ArcA in S. Typhimurium included those coding for ethanolamine utilization, lactate transport and metabolism, and succinate dehydrogenases. Salmonella-specific genes/operons regulated by ArcA included those required for propanediol utilization, flagellar genes (mcpAC, cheV, Gifsy-1 prophage genes, and three SPI-3 genes (mgtBC, slsA, STM3784. In agreement with our microarray data, the arcA mutant was non-motile, lacked flagella, and was as virulent in mice as the WT. Additionally, we identified a set of 120 genes whose regulation was shared with the anaerobic redox regulator, Fnr. Conclusion(s We have identified the ArcA regulon in anaerobically grown S. Typhimurium. Our results demonstrated that in S. Typhimurium, ArcA serves as a transcriptional regulator coordinating cellular metabolism, flagella

  20. Concentration device

    DEFF Research Database (Denmark)

    2013-01-01

    A concentration device (2) for filter filtration concentration of particles (4) from a volume of a fluid (6). The concentration device (2) comprises a filter (8) configured to filter particles (4) of a predefined size in the volume of the fluid (6). The concentration device (2) comprises...

  1. Níveis de sensibilidade de enterobactérias, em particular Salmonella typhi, a rifamicina S.V.

    Directory of Open Access Journals (Sweden)

    Ivone R. Suassuna

    1969-04-01

    Full Text Available Em face à predominante eliminação biliar da rifamicina S.V. atingindo concentrações muitas vêzes superiores aos níveis séricos obtidos com as doses terapêuticas, e pelo possível interêsse dessa verificação para o tratamento dos portadores biliares crônicos de Salmonella typhi determinou-se a concentração mínima inibitória de 165 estirpes de enterobactérias, incluindo 77 amostras de S. typhi. Foi verificado que a maioria das cepas de Escherichia coli, Shigella e Proteus mirabilis correspondiam a uma concentração inibitória mínima entre 33 a 65 μg/ml. Entre 65 e 128 μg/ml foram determinadas as concetrações inibitórias mínimas da maioria das outras espécies de Proteus, de Providencia e de Klebsiella. Para Salmonella e Enterobacter o limite mínino de sensibilidade foi, em regra, igual ou superior a 128 μg/ml. Diferenças mais acentuadas de comportamento entre as enterobactérias foram observadas quanto à ação bactericida da rifamicidas S.V. De uma maneira geral, para E. coli e Shigella, as concentrações inibitórias mínimas já referidas. Para as espécies de Proteus e Providencia houve variação maior de comportamento, mas tendência a que o efeito bactericidas fôsse encontrado em concentrações que correspondiam a 4 vêzes as bacteriostáticas para as mesmas espécies. Finalmente, de modo pouco feliz para os propósitos visados, em Salmonella, com a inclusão de S. typhi, não foi atingido um efeito bactericida, com as mais altas concentrações usadas as quais corresponderam em média a 6 vêzes as concentrações bacteriostáticas para esse gênero.

  2. Evaluation of radon and their daughters concentration and estimative of effective dose in a waste deposits at the ore treatment unity of INB/Pocos de Caldas, Brazil; Avaliacao da concentracao de radonio e seus filhos e estimativa de dose efetiva em um deposito de rejeitos na unidade de tratamento de minerios da INB/Caldas

    Energy Technology Data Exchange (ETDEWEB)

    Dantas, Marcelino V.A.; Garcia Filho, Oswaldo; Antunes, Marcos M.; Junior, Joao V.S.; Py Junior, Delcy A., E-mail: marcelino@inb.gov.b, E-mail: wspereira@inb.gov.b, E-mail: ogarcia@inb.gov.b, E-mail: antunes@inb.gov.b, E-mail: Joao@inb.gov.b, E-mail: delcy@inb.gov.b [Industrias Nucleares do Brasil (UTM/INB), Caldas, MG (Brazil). Unidade de Tratamento de Minerios; Pereira, Wagner S. [Industrias Nucleares do Brasil (UTM/INB), Caldas, MG (Brazil). Unidade de Tratamento de Minerios; Universidade Federal Fluminense (IB/UFF), Niteroi, RJ (Brazil). Inst. de Biologia. Lab. de Radiobiologia e Radiometria Pedro Lopes dos Santos

    2011-10-26

    This paper conducts a surveillance of radon and their short half-life daughters gas concentration, inside the warehouse due to these gas inhalation. The results showed that the average concentration inside the warehouse ix approximately 700 Bq/m{sup 3} and the effective dose of an IOE, related to that concentration would be 5.0 mSv/year, therefore being 4 times lower than the established limit of 20 mSv/year

  3. Transforming growth factor-beta 1 downregulates dexamethasone-induced tetranectin gene expression during the in vitro mineralization of the human osteoblastic cell line SV-HFO

    DEFF Research Database (Denmark)

    Iba, K; Sawada, N; Chiba, H

    1995-01-01

    treatment as evidenced by Northern blotting. When transforming growth factor-beta 1 (TGF-beta 1) was added together with dexamethasone to the SV-HFO cell cultures, the mineralization process was markedly suppressed and the expression of tetra nectin and alkaline phosphatase was downregulated in a dose...

  4. Ambtscriminaliteit aangegeven? : Een onderzoek naar het opvolgen van en kennis over de wettelijke verplichting tot aangifte van artikel 162 Sv misdrijven

    NARCIS (Netherlands)

    Vries Robbé, E. de; Cornelissens, A.; Ferwerda, H.

    2008-01-01

    Dit is een onderzoek naar de werking van de aangifteplicht bij ambtscriminaliteit (art 162 Sv). Het gaat dan bijvoorbeeld om het aannemen van steekpenningen en misdrijven waarbij ambtenaren een bijzondere ambtsplicht schenden. De aangifteplicht raakt de klokkenluidersregeling en maakt onderdeel uit

  5. An Investigation of the Validity and Reliability of the Adapted Mathematics Anxiety Rating Scale-Short Version (MARS-SV) among Turkish Students

    Science.gov (United States)

    Baloglu, Mustafa

    2010-01-01

    This study adapted the Mathematics Anxiety Rating Scale-Short Version (MARS-SV) into Turkish and investigated the validity and reliability of the adapted instrument. Twenty-five bilingual experts agreed on the language validity, and 49 Turkish language experts agreed on the conformity and understandability of the scale's items. Thirty-two subject…

  6. Bypass of a site-specific cis-Syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell-free extracts.

    Science.gov (United States)

    Ensch-Simon, I; Burgers, P M; Taylor, J S

    1998-06-02

    The key step in skin cancer induction by UV light is thought to be the mutagenic DNA synthesis past a DNA photoproduct in a proto-oncogene or tumor suppressor gene. To investigate this critical step, we have constructed an SV40 vector containing a cis-syn thymine dimer, the major DNA photoproduct induced by UVB light, within an AseI site at a location that would initially be replicated by leading strand synthesis. When the dimer-containing SV40 vector was incubated with cell-free HeLa extracts in the presence of TAg, and then digested with AseI, a 2325 bp fragment corresponding to inhibition of cleavage at the dimer site was observed, suggesting that the dimer had terminated synthesis and/or had been bypassed. When the reaction was limited to one round of replication and the products of restriction enzyme digestion were examined by denaturing gel electrophoresis, bands corresponding to both termination and bypass were observed in roughly a one-to-one ratio. Whereas increasing the dNTP concentration from 10 microM to 1 mM increased the ratio of bypass to termination from 0.6 to 2.6, it had no effect on the site of termination, which occurred exclusively one nucleotide before the dimer. Experiments in which dGTP was held constant at 25 microM and various combinations of the remaining nucleotides were raised from 25 microM to 1 mM showed substantial increases in the bypass-to-termination ratio, with the greatest effect seen for raising all three nucleotides to 1 mM. Replication by primary fibroblast XPV extracts was also investigated and found to be greatly stimulated by rhRPA, whereas the stimulatory effect for HeLa cell extracts was variable. In the presence of rhRPA, the XPV extracts were also found to bypass the cis-syn dimer, which contrasts with a recent report that could not detect dimer bypass in SV40 transformed XPV extracts in the absence of added replication factors [Cordeiro-Stone, M., et al. (1997) J. Biol. Chem. 272, 13945-13954].

  7. Evaluation of the Reference Numerical Parameters of the Monthly Method in ISO 13790 Considering S/V Ratio

    Directory of Open Access Journals (Sweden)

    Hee-Jeong Kwak

    2015-01-01

    Full Text Available Many studies have investigated the accuracy of the numerical parameters in the application of the quasi steady-state calculation method. The aim of this study is to derive the reference numerical parameters of the ISO 13790 monthly method by reflecting the surface-to-volume (S/V ratio and the characteristics of the structures. The calculation process was established, and the parameters necessary to derive the reference numerical parameters were calculated based on the input data prepared for the established calculation processes. The reference numerical parameters were then derived through regression analyses of the calculated parameters and the time constant. The parameters obtained from an apartment building and the parameters of the international standard were both applied to the Passive House Planning Package (PHPP and EnergyPlus programs, and the results were analyzed in order to evaluate the validity of the results. The analysis revealed that the calculation results based on the parameters derived from this study yielded lower error rates than those based on the default parameters in ISO 13790. However, the differences were shown to be negligible in the case of high heat capacity.

  8. [Effects of histone deacetylase inhibitor sodium valproate on the physical and behavioral development of 129SV mice].

    Science.gov (United States)

    Burenkova, O V; Aleksandrova, E A; Zarayskaya, I Yu

    2015-01-01

    Sodium valproate is a widely used antiepileptic drug at high dosage levels, but it has been shown to produce a variety of toxic side-effects when used during perinatal period. These effects include increased risk of congenital anomalies and autism. For this reason, valproate is commonly employed in animal model of autism. Sodium valproate has multiple molecular targets including histone deacetylases. Therefore valproate can be utilized as a tool for the modulation of epigenetic modifications of the genome via inhibition of histone deacetylases. It is known that administration of sodium valproate at a dose of 50 mg/kg during early postnatal period leads to increase of the histone H3 acetylation level in the brain. The aim of the present study was to evaluate the effects of multiple valproate injections from 3rd to 6th postnatal day (50 mg/kg s.c.) on physical and sensorimotor development of 129Sv mice. The standard battery of tests was used. Our results show that valproate have no negative effect on physical development, sensorimotor function, and social behavior. The obtained results support the applicability of sodium valproate in our dosing schedule for further experimental modulation of histone acetulation level in the developing brain.

  9. Spectral variability of /s/ in sV and sCV sequences produced by adults and children

    Science.gov (United States)

    Munson, Benjamin

    2002-05-01

    Previous research has demonstrated that both children and adults produce /s/ with greater spectral variability in /sp/ sequences than /st/ sequences, when these sequences are embedded in the medial position of CVCCVC nonwords [B. Munson, J. Acoust. Soc. Am. 110, 1203-1206 (2001)]. The current study examined whether this result could be replicated when /s/ is embedded in syllable-onset clusters, with a variety of following consonants and vowels. Adults and children aged 3-7 were recorded producing multiple tokens of sV and sCV nonwords, where the vowel was either /i/, /opena/, or /u/, and the consonant was either /p/, /t/, /w/, or /l/. For each token, the spectral mean of non-overlapping 10-ms windows of frication noise was calculated. Nonlinear regressions of the form y=aebx were used to predict the spectral mean of each portion of frication noise from its position in the fricative. The resulting measure of model fit, R2, was used as an index of within-speaker variability. For each participant, separate R2 values were calculated for /s/ in each of the 15 phonetic contexts. Analyses will address the influence of age, consonant context, and vowel context on spectral variability.

  10. StralSV: assessment of sequence variability within similar 3D structures and application to polio RNA-dependent RNA polymerase

    Energy Technology Data Exchange (ETDEWEB)

    Zemla, A; Lang, D; Kostova, T; Andino, R; Zhou, C

    2010-11-29

    Most of the currently used methods for protein function prediction rely on sequence-based comparisons between a query protein and those for which a functional annotation is provided. A serious limitation of sequence similarity-based approaches for identifying residue conservation among proteins is the low confidence in assigning residue-residue correspondences among proteins when the level of sequence identity between the compared proteins is poor. Multiple sequence alignment methods are more satisfactory - still, they cannot provide reliable results at low levels of sequence identity. Our goal in the current work was to develop an algorithm that could overcome these difficulties and facilitate the identification of structurally (and possibly functionally) relevant residue-residue correspondences between compared protein structures. Here we present StralSV, a new algorithm for detecting closely related structure fragments and quantifying residue frequency from tight local structure alignments. We apply StralSV in a study of the RNA-dependent RNA polymerase of poliovirus and demonstrate that the algorithm can be used to determine regions of the protein that are relatively unique or that shared structural similarity with structures that are distantly related. By quantifying residue frequencies among many residue-residue pairs extracted from local alignments, one can infer potential structural or functional importance of specific residues that are determined to be highly conserved or that deviate from a consensus. We further demonstrate that considerable detailed structural and phylogenetic information can be derived from StralSV analyses. StralSV is a new structure-based algorithm for identifying and aligning structure fragments that have similarity to a reference protein. StralSV analysis can be used to quantify residue-residue correspondences and identify residues that may be of particular structural or functional importance, as well as unusual or unexpected

  11. The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients

    Directory of Open Access Journals (Sweden)

    Rehab M. Samaka

    2015-01-01

    Full Text Available Diffuse large B-cell lymphoma (DLBCL is the most common type of lymphomas worldwide. The pathogenesis of lymphomas is not yet well understood. SV40 induces malignant transformation by the large T-antigen (L-TAG and promotes transformation by binding and inactivating p53 and pRb. L-TAG can bind pRb promoting the activation of the E2F1 transcription factor, thus inducing the expression of genes required for the entry to the S phase and leading to cell transformation. This immunohistochemical study was conducted to assess the prognostic role and relationship of SV40 L-TAG and E2F1 in diffuse large B-cell lymphoma (DLBCL of Egyptian patients. This retrospective study was conducted on 105 tissue specimens including 20 follicular hyperplasia and 85 DLBCL cases. SV40 L-TAG was identified in 3/85 (4% of DLBCL. High Ki-67 labeling index (Ki-67 LI and apoptotic count were associated with high E2F1 expression (p<0.001 for all. No significant association was reached between E2F1 and SV40. E2F1 expression proved to be the most and first independent prognostic factor on overall survival of DLBCL patients (HR = 5.79, 95% CI = 2.3–14.6, and p<0.001. Upregulation of E2F1 has been implicated in oncogenesis, prognosis, and prediction of therapeutic response but is not seemingly to have a relationship with the accused SV40.

  12. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.

    Science.gov (United States)

    March, Amelia; Borchelt, David; Golde, Todd; Janus, Christopher

    2014-02-01

    Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCrl and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms.

  13. Concentration risk

    Directory of Open Access Journals (Sweden)

    Matić Vesna

    2016-01-01

    Full Text Available Concentration risk has been gaining a special dimension in the contemporary financial and economic environment. Financial institutions are exposed to this risk mainly in the field of lending, mostly through their credit activities and concentration of credit portfolios. This refers to the concentration of different exposures within a single risk category (credit risk, market risk, operational risk, liquidity risk.

  14. SvSXP

    DEFF Research Database (Denmark)

    Andersen, Ulla Vestergaard; Howe, Daniel K.; Dangoudoubiyam, Sriveny

    2013-01-01

    Strongyle parasites are ubiquitous in grazing horses. Strongylus vulgaris, the most pathogenic of the large strongyles, is known for its extensive migration in the mesenteric arterial system. The lifecycle of S. vulgaris is characterised by a long prepatent period where the migrating larvae...... are virtually undetectable as there currently is no test available for diagnosing prepatent S. vulgaris infection. Presence of S. vulgaris larvae in the arterial system causes endarteritis and thrombosis with a risk of non-strangulating intestinal infarctions. Emergence of anthelmintic resistance among...

  15. SV-AUTOPILOT

    NARCIS (Netherlands)

    Leung, Wai Yi; Marschall, Tobias; Paudel, Yogesh; Falquet, Laurent; Mei, Hailiang; Schönhuth, Alexander; Maoz Moss, Tiffanie Yael

    2015-01-01

    Background: Many tools exist to predict structural variants (SVs), utilizing a variety of algorithms. However, they have largely been developed and tested on human germline or somatic (e.g. cancer) variation. It seems appropriate to exploit this wealth of technology available for humans also for

  16. SV Ganesan Srinivasan Natarajan

    Indian Academy of Sciences (India)

    The anions consist of a ring of five MoO6 distorted octahedra with four edge connections and one corner connection. The phosphate groups cap the pentamolybdate ring anion on either side. The anion is stabilized by strong hydrogen bonds involving the hydrogen atoms of the amine molecules and the oxygen atoms of the ...

  17. Concentrator Photovoltaics

    CERN Document Server

    Luque, Antonio L

    2007-01-01

    Photovoltaic solar-energy conversion is one of the most promising technologies for generating renewable energy, and conversion of concentrated sunlight can lead to reduced cost for solar electricity. In fact, photovoltaic conversion of concentrated sunlight insures an efficient and cost-effective sustainable power resource. This book gives an overview of all components, e.g. cells, concentrators, modules and systems, for systems of concentrator photovoltaics. The authors report on significant results related to design, technology, and applications, and also cover the fundamental physics and market considerations. Specific contributions include: theory and practice of sunlight concentrators; an overview of concentrator PV activities; a description of concentrator solar cells; design and technology of modules and systems; manufacturing aspects; and a market study.

  18. Discrimination of dementia with Lewy bodies from Alzheimer's disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra.

    Science.gov (United States)

    Nakatsuka, Tomoya; Imabayashi, Etsuko; Matsuda, Hiroshi; Sakakibara, Ryuji; Inaoka, Tsutomu; Terada, Hitoshi

    2013-05-01

    The purpose of this study was to identify brain atrophy specific for dementia with Lewy bodies (DLB) and to evaluate the discriminatory performance of this specific atrophy between DLB and Alzheimer's disease (AD). We retrospectively reviewed 60 DLB and 30 AD patients who had undergone 3D T1-weighted MRI. We randomly divided the DLB patients into two equal groups (A and B). First, we obtained a target volume of interest (VOI) for DLB-specific atrophy using correlation analysis of the percentage rate of significant whole white matter (WM) atrophy calculated using the Voxel-based Specific Regional Analysis System for Alzheimer's Disease (VSRAD) based on statistical parametric mapping 8 (SPM8) plus diffeomorphic anatomic registration through exponentiated Lie algebra, with segmented WM images in group A. We then evaluated the usefulness of this target VOI for discriminating the remaining 30 DLB patients in group B from the 30 AD patients. Z score values in this target VOI obtained from VSRAD were used as the determinant in receiver operating characteristic (ROC) analysis. Specific target VOIs for DLB were determined in the right-side dominant dorsal midbrain, right-side dominant dorsal pons, and bilateral cerebellum. ROC analysis revealed that the target VOI limited to the midbrain exhibited the highest area under the ROC curves of 0.75. DLB patients showed specific atrophy in the midbrain, pons, and cerebellum. Midbrain atrophy demonstrated the highest power for discriminating DLB and AD. This approach may be useful for determining the contributions of DLB and AD pathologies to the dementia syndrome.

  19. Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects.

    Science.gov (United States)

    Sargentini-Maier, Maria Laura; Espié, Pascal; Coquette, Alain; Stockis, Armel

    2008-01-01

    This study was designed to investigate the human absorption, disposition, and mass balance of (14)C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. Six healthy male subjects received a single p.o. dose of (14)C-brivaracetam (150 mg, 82 microCi, or 3.03 MBq). Serial blood and complete urine and feces were collected until 144 h postdose. Expired air samples were obtained until 24 h. Brivaracetam was rapidly absorbed, with C(max) of 4 mug/ml occurring within 1.5 h of dosing. Unchanged brivaracetam amounted to 90% of the total plasma radioactivity, suggesting a modest first-pass effect. Plasma protein binding of radioactivity was low (17.5%). Urinary excretion exceeded 90% after 2 days, and the final mass balance reached 96.8% of the radioactivity in urine and 0.7% in feces. Only 8.6% of the radioactive dose was recovered in urine as unchanged brivaracetam, the remainder being identified as non-cytochrome P450 (P450)- and P450-dependent biotransformation products resulting from hydrolysis of the amide moiety (M9, 34.2%), hydroxylation of the n-propyl side chain (M1b, 15.9%), and a combination of these two pathways leading to the hydroxy acid (M4b, 15.2%). Minor amounts of taurine and glucuronic acid conjugates and other oxidized derivatives were also identified. Brivaracetam is completely absorbed, is weakly bound to plasma proteins, extensively biotransformed through several metabolic pathways, and eliminated renally.

  20. Evaluation of annual effective dose from indoor radon concentration in Eastern Province, Dammam, Saudi Arabia

    Science.gov (United States)

    Abuelhia, E.

    2017-11-01

    The aim of this study is to determine the indoor radon concentration and to evaluate the annual effective dose received by the inhabitants in Dammam, Al-Khobar, and compare it with new premises built at university of dammam. The research has been carried out by using active detection method; Electronic Radon Detector (RAD-7) a solid state α-detector with its special accessories. The indoor radon concentration measured varies from 10.2 Bqm-3 to 25.8 Bqm-3 with an average value of 18.8 Bqm-3 and 19.7 Bqm-3 to 23.5 Bqm-3 with an average value of 21.7 Bqm-3, in Dammam and Al-khobar dwellings, respectively. In university of dammam the radon concentration varies from 7.4 Bqm-3 to 15.8 Bqm-3 with an average value of 9.02 Bqm-3. The values of annual effective doses were found to be 0.47mSv/y, 0.55mSv/y, and 0.23mSv/y, in Dammam, Al-khobar and university new premises, respectively. The average radon concentration in the old dwellings was two times compared to that in the new premises and it was 25.4 Bqm-3 lower than the world average value of 40 Bqm-3 reported by the UNSCEAR. The annual effective doses in the old dwellings was found to be (0.55mSv/y) two times the doses received at the new premises, and below the world wide average of 1.15mSv/y reported by ICRP (2010). The indoor radon concentration in the study region is safe as far as health hazard is concerned.

  1. Concentrated Ownership

    DEFF Research Database (Denmark)

    Rose, Caspar

    2014-01-01

    This entry summarizes the main theoretical contributions and empirical findings in relation to concentrated ownership from a law and economics perspective. The various forms of concentrated ownership are described as well as analyzed from the perspective of the legal protection of investors...

  2. STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1/SV40 T/t-antigen transgenic mice.

    Directory of Open Access Journals (Sweden)

    Florence Meyer-Losic

    Full Text Available Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequently, new drugs are urgently required. STX140, a compound previously shown to have excellent efficacy against many tumors, is here compared to paclitaxel in three translational in vivo breast cancer models, a rat model of peripheral neuropathy, and through pharmacological testing. Three different in vivo mouse models of breast cancer were used; the metastatic 4T1 orthotopic model, the C3(1/SV40 T-Ag model, and the MDA-MB-231 xenograft model. To determine TIX and pharmacological profile of STX140, a comprehensive dosing regime was performed in mice bearing MDA-MD-231 xenografts. Finally, peripheral neuropathy was examined using a rat plantar thermal hyperalgesia model. In the 4T1 metastatic model, STX140 and paclitaxel significantly inhibited primary tumor growth and lung metastases. All C3(1/SV40 T-Ag mice in the control and paclitaxel treated groups developed palpable mammary cancer. STX140 blocked 47% of tumors developing and significantly inhibited growth of tumors that did develop. STX140 treatment caused a significant (P<0.001 survival advantage for animals in early and late intervention groups. Conversely, in C3(1/SV40 T-Ag mice, paclitaxel failed to inhibit tumor growth and did not increase survival time. Furthermore, paclitaxel, but not STX140, induced significant peripheral neuropathy and neutropenia. These results show that STX140 has a greater anti-cancer efficacy, TIX, and reduced neurotoxicity compared to paclitaxel in C3(1/SV40 T-Ag mice and therefore may be of significant benefit to patients with breast cancer.

  3. Piecu svēto kalnu nozīme Ķīnas tradicionālajā pasaules skatījumā

    OpenAIRE

    Līviņš, Rolands

    2017-01-01

    Bakalaura darba „Piecu svēto kalnu nozīme Ķīnas tradicionālajā pasaules skatījumā” mērķis ir apskatīt Ķīnas Piecus svēto kalnus – vujue, to izcelsmi un nozīmi ķīniešu pasaules skatījumā. Darba gaitā ir apskatīta vujue kalnu sistēmas izveide, kas balstās uz piecu elementu teoriju. Kā arī tiek aplūkoti ar šiem kalniem un piecu elementu teoriju sasaistītie aspekti – daoistu meditāciju alas un nemirstības ideja. Darba izstrādes gaitā noskaidrots kādu lomu ieņem Pieci svētie kalni un kad tāda kaln...

  4. Development, pilot testing and psychometric validation of a short version of the coronary artery disease education questionnaire: The CADE-Q SV.

    Science.gov (United States)

    Ghisi, Gabriela Lima de Melo; Sandison, Nicole; Oh, Paul

    2016-03-01

    To develop, pilot test and psychometrically validate a shorter version of the coronary artery disease education questionnaire (CADE-Q), called CADE-Q SV. Based on previous versions of the CADE-Q, cardiac rehabilitation (CR) experts developed 20 items divided into 5 knowledge domains to comprise the first version of the CADE-Q SV. To establish content validity, they were reviewed by an expert panel (N=12). Refined items were pilot-tested in 20 patients, in which clarity was provided. A final version was generated and psychometrically-tested in 132CR patients. Test-retest reliability was assessed via the intraclass correlation coefficient (ICC), the internal consistency using Cronbach's alpha, and criterion validity with regard to patients' education and duration in CR. All ICC coefficients meet the minimum recommended standard. All domains were considered internally consistent (α>0.7). Criterion validity was supported by significant differences in mean scores by educational level (pCADE-Q SV was demonstrated to have good reliability and validity. This is a short, quick and appropriate tool for application in clinical and research settings, assessing patients' knowledge during CR and as part of education programming. Copyright © 2015. Published by Elsevier Ireland Ltd.

  5. Arginine-rich cross-linking peptides with different SV40 nuclear localization signal content as vectors for intranuclear DNA delivery.

    Science.gov (United States)

    Bogacheva, Mariia; Egorova, Anna; Slita, Anna; Maretina, Marianna; Baranov, Vladislav; Kiselev, Anton

    2017-11-01

    The major barriers for intracellular DNA transportation by cationic polymers are their toxicity, poor endosomal escape and inefficient nuclear uptake. Therefore, we designed novel modular peptide-based carriers modified with SV40 nuclear localization signal (NLS). Core peptide consists of arginine, histidine and cysteine residues for DNA condensation, endosomal escape promotion and interpeptide cross-linking, respectively. We investigated three polyplexes with different NLS content (10 mol%, 50 mol% and 90 mol% of SV40 NLS) as vectors for intranuclear DNA delivery. All carriers tested were able to condense DNA, to protect it from DNAase I and were not toxic to the cells. We observed that cell cycle arrest by hydroxyurea did not affect transfection efficacy of NLS-modified carriers which we confirmed using quantitative confocal microscopy analysis. Overall, peptide carrier modified with 90 mol% of SV40 NLS provided efficient transfection and nuclear uptake in non-dividing cells. Thus, incorporation of NLS into arginine-rich cross-linking peptides is an adequate approach to the development of efficient intranuclear gene delivery vehicles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Concentrating Radioactivity

    Science.gov (United States)

    Herrmann, Richard A.

    1974-01-01

    By concentrating radioactivity contained on luminous dials, a teacher can make a high reading source for classroom experiments on radiation. The preparation of the source and its uses are described. (DT)

  7. Individual external doses below the lowest reference level of 1 mSv per year five years after the 2011 Fukushima nuclear accident among all children in Soma City, Fukushima: A retrospective observational study.

    Science.gov (United States)

    Tsubokura, Masaharu; Murakami, Michio; Nomura, Shuhei; Morita, Tomohiro; Nishikawa, Yoshitaka; Leppold, Claire; Kato, Shigeaki; Kami, Masahiro

    2017-01-01

    After the 2011 Fukushima Daiichi nuclear power plant accident, little information has been available on individual doses from external exposure among residents living in radioactively contaminated areas near the nuclear plant; in the present study we evaluated yearly changes in the doses from external exposure after the accident and the effects of decontamination on external exposure. This study considered all children less than 16 years of age in Soma City, Fukushima who participated in annual voluntary external exposure screening programs during the five years after the accident (n = 5,363). In total, 14,405 screening results were collected. The median participant age was eight years. The geometric mean levels of annual additional doses from external exposure attributable to the Fukushima accident, decreased each year: 0.60 mSv (range: not detectable (ND)-4.29 mSv), 0.37 mSv (range: ND-3.61 mSv), 0.22 mSv (range: ND-1.44 mSv), 0.20 mSv (range: ND-1.87 mSv), and 0.17 mSv (range: ND-0.85 mSv) in 2011, 2012, 2013, 2014, and 2015, respectively. The proportion of residents with annual additional doses from external exposure of more than 1 mSv dropped from 15.6% in 2011 to zero in 2015. Doses from external exposure decreased more rapidly than those estimated from only physical decay, even in areas without decontamination (which were halved in 395 days from November 15, 2011), presumably due to the weathering effects. While the ratios of geometric mean doses immediately after decontamination to before were slightly lower than those during the same time in areas without decontamination, annual additional doses reduced by decontamination were small (0.04-0.24 mSv in the year of immediately after decontamination was completed). The results of this study showed that the levels of external exposure among Soma residents less than 16 years of age decreased during the five years after the Fukushima Daiichi nuclear power plant accident. Decontamination had only limited and

  8. Complementary person-supervisor fit : an investigation of supplies-values (S-V) fit, leader-member exchange (LMX) and work outcomes.

    OpenAIRE

    Marstand, A.F.; Martin, R.; Epitropaki, O.

    2016-01-01

    By applying the supplies-values (S-V) fit approach from the complementary person-environment (P-E) fit literature to the leader-employee perspective, and drawing upon social exchange theory, we examine how fulfillment of different work values is related to Leader-Member Exchange (LMX) and work outcomes. First, polynomial regression analyses combined with response surface analysis of data collected at two time points (N = 316) showed that LMX (Time 2) was higher the more the leader fulfills th...

  9. Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.

    Science.gov (United States)

    Nicolas, Jean-Marie; Hannestad, Jonas; Holden, Daniel; Kervyn, Sophie; Nabulsi, Nabeel; Tytgat, Dominique; Huang, Yiyun; Chanteux, Hugues; Staelens, Ludovicus; Matagne, Alain; Mathy, François-Xavier; Mercier, Joël; Stockis, Armel; Carson, Richard E; Klitgaard, Henrik

    2016-02-01

    Rapid distribution to the brain is a prerequisite for antiepileptic drugs used for treatment of acute seizures. The preclinical studies described here investigated the high-affinity synaptic vesicle glycoprotein 2A (SV2A) antiepileptic drug brivara-cetam (BRV) for its rate of brain penetration and its onset of action. BRV was compared with levetiracetam (LEV). In vitro permeation studies were performed using Caco-2 cells. Plasma and brain levels were measured over time after single oral dosing to audiogenic mice and were correlated with anticonvulsant activity. Tissue distribution was investigated after single dosing to rat (BRV and LEV) and dog (LEV only). Positron emission tomography (PET) displacement studies were performed in rhesus monkeys using the SV2A PET tracer [11C]UCB-J. The time course of PET tracer displacement was measured following single intravenous (IV) dosing with LEV or BRV. Rodent distribution data and physiologically based pharmacokinetic (PBPK) modeling were used to compute blood-brain barrier permeability (permeability surface area product, PS) values and then predict brain kinetics in man. In rodents, BRV consistently showed a faster entry into the brain than LEV; this correlated with a faster onset of action against seizures in audiogenic susceptible mice. The higher permeability of BRV was also demonstrated in human cells in vitro. PBPK modeling predicted that, following IV dosing to human subjects, BRV might distribute to the brain within a few minutes compared with approximately 1 h for LEV (PS of 0.315 and 0.015 ml/min/g for BRV and LEV, respectively). These data were supported by a nonhuman primate PET study showing faster SV2A occupancy by BRV compared with LEV. These preclinical data demonstrate that BRV has rapid brain entry and fast brain SV2A occupancy, consistent with the fast onset of action in the audiogenic seizure mice assay. The potential benefit of BRV for treatment of acute seizures remains to be confirmed in clinical

  10. Dynamic Study on the 400 kV 60 km Kyndbyværket – Asnæsværket Line

    DEFF Research Database (Denmark)

    Ohno, Teruo

    lines. The PhD project focuses on the 400 kV 60 km Kyndbyværket – Asnæsværket line, which will feed power to Copenhagen, the Danish capital. The PhD project addresses major problems and potential countermeasures related to the installation and operation of a long cable line, through: (1) Insulation...... coordination study (2) Derivation of theoretical formulas of sequence currents (3) Identification of dominant frequency components contained in the overvoltage (4) Analysis on the statistical distribution of energization overvoltages (5) Protection study...

  11. Hypothalamic neurosecretory and circadian vasopressinergic neuronal systems in the blind cone-rod homeobox knock out mouse (Crx(-/-) ) and the 129sv wild type mouse

    DEFF Research Database (Denmark)

    Rovsing, Louise; Rath, Martin Fredensborg; Møller, Morten

    2013-01-01

    Vasopressin (AVP) is both a neuroendocrine hormone located in magnocellular neurosecretory neurons of the hypothalamus of mammals but also a neurotransmitter/neuromodulator in the parvocellular suprachiasmatic nucleus (SCN). The SCN is the endogenous clock of the brain and exhibits a prominent...... circadian AVP-rhythm. We have in this study of the brown 129sv mouse and the visual blind cone-rod homeobox gene knock out mouse (Crx(-/-) ) with degeneration of the retinal rods and cones, but a preserved non-image forming optic system, studied the temporal Avp-expression in both the neurosecretory...

  12. The AT-rich tract of the SV40 ori core: negative synergism and specific recognition by single stranded and duplex DNA binding proteins.

    OpenAIRE

    Galli, Ivo; Iguchi-Ariga, Sanae M. M.; Ariga, Hiroyoshi

    1992-01-01

    The cellular oncogene c-myc encodes a nuclear protein that is considered to play a role in cell proliferation. In this report, the region upstream from the transcriptional promoter of the c-myc gene was examined for regulatory activity on its expression during cell cycle. Plasmids which contain the upstream region of human c-myc gene linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to rat 3Y1 cells together with pSV2Hg (containing the hygromycin resistance...

  13. Response to ethanol induced ataxia between C57BL/6J and 129X1/SvJ mouse strains using a treadmill based assay

    OpenAIRE

    Hansen, Stephen T.; Pulst, Stefan M.

    2012-01-01

    More sensitive assays of mouse motor ataxia may provide a better understanding of the pathological profile. Treadmill gait analysis using ventral imaging allows for unhindered access to the ambulating mouse. In contrast to genetic mutations or exogenous brain injury, ethanol (EtOH) allows for the detection of dose dependent changes in motor behavior, which can be used to assess an assay’s detection sensitivity. EtOH induced ataxia was assessed in C57BL/6J (B6) and 129X1/SvJ (129) mice using t...

  14. Projekt uređenja knjižnice samostana sv. Frane u Zadru (izvještaj od 13. prosinca 2008.

    Directory of Open Access Journals (Sweden)

    Zoran Velagić

    2008-07-01

    Full Text Available Uređenje knjižnice samostana sv. Frane u Zadru zajednički je projekt samostana sv. Frane i Odjela za knjižničarstvo Sveučilišta u Zadru. Kratkoročni je cilj projekta čišćenje i inventarizacija iznimno vrijednog fonda te knjižnice koji se procjenjuje na više od 40 000 svezaka, a sastoji se od stotinjak inkunabula, deset koralnih oslikanih kodeksa te mnogobrojnih klasičnih, moralnih, teoloških i prirodoznanstvenih djela. Pretpostavlja se da knjižnica u samostanu djeluje od njegova osnutka u 13. stoljeću, otkada je prikupljana i građa današnjeg fonda knjižnice. Dugoročni plan uređenja podrazumijeva izradu projekta uređenja knjižnice (arhitektonski i građevinski dio, stručnu obradu, zaštitu, izradu mrežno dostupnog kataloga, digitalizaciju odabranih primjeraka knjižnične građe i naposljetku otvaranje knjižnice javnosti.

  15. Hyper production of alkali stable xylanase in lesser duration by Bacillus pumilus SV-85S using wheat bran under solid state fermentation.

    Science.gov (United States)

    Nagar, Sushil; Mittal, Anuradha; Kumar, Davender; Kumar, Lalit; Kuhad, Ramesh Chander; Gupta, Vijay Kumar

    2011-10-01

    High level production of an extracellular cellulase-poor alkali stable xylanase has been conceded from newly isolated Bacillus pumilus SV-85S under solid state fermentation using wheat bran as a substrate. Optimization of the fermentation conditions enhanced the enzyme production to 73,000 ± 1,000 IU/g dry substrate, which was 13.8-fold higher than unoptimized conditions (5,300 IU/g). The enzyme titre was highest after 48 h of incubation at 30°C with 1:3 ratios of substrate to moistening agent using wheat bran as a carbon source. The enzyme could be produced in significant levels by using either tap water or distilled water alone as a moistening agent. An elevated production of xylanase by B. pumilus SV-85S in the presence of wheat bran, a cheap and easily available agro-residue, in shorter duration would apparently reduce the enzyme cost substantially. The enzyme was completely stable over a broad pH (5-11) range and retained 52% of its activity at a temperature of 70°C for 30 min. The desired characteristics of this enzyme together with economic production would be important for its application in paper and pulp industry. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. RADON CONCENTRATIONS IN UNDERGROUND DRINKING WATER IN PARTS OF CITIES, CHINA.

    Science.gov (United States)

    Wu, Yunyun; Cui, Hongxing; Liu, Jianxiang; Shang, Bing; Su, Xu

    2017-08-31

    222Rn concentrations in underground drinking water samples in 12 cities from seven provinces (municipalities), China were determined by using a continuous radon monitor with air-water exchanger. A total of 73 underground water samples were collected. The observed radon levels were in a range of 1.0-63.8 Bq l-1, with a mean of 11.8 Bq l-1. The annual effective dose from inhalation of water-borne radon for average radon content in underground water was 72.6 μSv and for maximal observed radon concentration in underground water the corresponding dose was 393.8 μSv. The dose contribution of inhalation dose from water-borne radon should be paid attention in some granitic area. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Photometric activity of UX Ori stars and related objects in the near infrared and visual. BF Ori, CQ Tau, WW Vul, and SV Cep

    Science.gov (United States)

    Shenavrin, V. I.; Grinin, V. P.; Rostopchina-Shakhovskaja, A. N.; Demidova, T. V.; Shakhovskoi, D. N.

    2012-05-01

    We have analyzed the activity of four UX Ori stars in the near-IR ( JHKL) and visual ( V) using the results of long-term photometric observations. For comparison, we also obtained IR ( JHKLM) photometric observations of two visually quiet young stars of close spectral types (AB Aur and HD 190073). For the photometrically most active UX Ori stars BF Ori, CQ Tau, and WW Vul, the Algol-like declines of brightness in the visual, which are due to sporadic enhancements of the circumstellar extinction, are also observed (with decreasing amplitude) in the IR bands. A strict correlation between the V and J brightness variations is observed for all the stars except for SV Cep. For some of the UX Ori stars, a strong correlation between the visual and IR activity is observed up to L, where the main contribution to the emission is made by circumstellar dust. In the case of SV Cep, the visual variability is not correlated with the variability of the IR fluxes. On one occasion, a clear anti-correlation was even observed: a shallow, but prolonged decrease of the visual brightness was accompanied by an increase in the IR fluxes. This indicates that circumstellar clouds themselves can become powerful sources of IR emission. Our results provide evidence that the photometric activity of UX Ori stars is a consequence of instability of the deepest layers of their gas-dust accretion disks. In some cases (SV Cep), fluctuations of the density in this region are global, in the sense that they occur along a significant part of the circle marking the inner boundary of the dust disk. It is interesting that AB Aur, which is the quietest in the visual, appeared to be the most active in the IR. In contrast to UX Ori stars, the amplitude of its brightness variations increases from the J to the M band. It follows from analysis of the IR colors of this star that their variability cannot be described by models in which the variable IR emission has a temperature close to the sublimation temperature of

  18. Ethical Issues Related to the Promotion of a "100 mSv Threshold Assumption" in Japan after the Fukushima Nuclear Accident in 2011: Background and Consequences.

    Science.gov (United States)

    Tsuda, Toshihide; Lindahl, Lena; Tokinobu, Akiko

    2017-06-01

    This article describes the debates in Japan regarding the 100 mSv threshold assumption and ethical issues related to it, and explores the background to distorted risk information and absence of risk communication in Japan. Then we seek proper risk communication based on scientific evidence. On March 11, 2011 an accident occurred at the Fukushima Daiichi Nuclear Power Plant due to the Great East Japan Earthquake. Since then a number of misunderstandings have become common in Japan as a result of public statements by the Japanese and local governments that have no basis in medical science or are contradictory to medical science. Consequently, not only the population of Fukushima Prefecture, but also others, have been subjected to unnecessary exposure to radiation, against the As Low As Reasonably Achievable (ALARA) principle. The number of cases of thyroid cancer has increased by one or two orders of magnitude since the accident in Fukushima. However, the population has hardly been given any correct information from the central and local governments, medical societies, and media. The center of this problem is a statement on radiation-induced cancer (including thyroid cancer) made by the Japanese Government and Japanese medical academic societies indicating that "exposure of less than 100 mSv gives rise to no excess risk of cancer, and even if there is some resulting cancer it will be impossible to detect it" (this will be referred to as "the 100 mSv threshold assumption" from now onward). They have been saying this since April 2011 and have made no effort to correct it. Many Japanese began to notice this but correct information on radiation protection has reached only one part of the population. Risk communication should be based on scientific evidence, and providing it as information for the public is a key element. In Japan, governments and academic societies tried to communicate with the public without doing it. Ethical problems after the accident in Fukushima

  19. Concentrations of radiocesium in foods imported from Russia (1996-1998)

    Energy Technology Data Exchange (ETDEWEB)

    Sugiyama, Hideo; Terada, Hiroshi; Izumo, Yoshiro [Inst. of Public Health, Tokyo (Japan); Miyata, Masahiro; Watanabe, Yoshinori; Tsuchiya, Tetsu; Endo, Taigo; Yoshida, Akio; Maeda, Kenji

    2000-12-01

    The concentrations of radiocesium, {sup 137}Cs and {sup 134}Cs, were determined in foods imported from Russia between 1996 and 1998. A total of 143 samples, including cod roe (47 samples), crab (44), fish, including flatfish and halibut (18), ground fish meat (11), and shrimp (8), were collected in quarantine stations throughout Japan and measured with a high-purity Ge semiconductor detector and spectrometer. The concentrations of both {sup 137}Cs and {sup 134}Cs were determined in 115 of the samples, but only {sup 137}Cs was measured in the other 28 samples. {sup 137}Cs was detected in 24 samples, and the mean concentration was 0.06 Bq/kg in the raw samples and 36.7 Bq/kg in the dry samples. Japanese tsubugai shellfish had the highest concentration (0.50 Bq/kg) among the non-dried foods. Radiocesium was most frequently detected in cod roe (15 raw samples, 0.06 - 0.14 Bq/kg), followed by fish and shellfish, including ground fish meat (7 samples), dried bracken (1 sample), and dried kabanoanatake (a species of mushrooms) (1 sample). The radiocesium concentration in kabanoanatake was the highest in this survey. The concentrations of {sup 134}Cs in all samples was below the limit of detection. The concentrations of radiocesium in foods imported from Russia did not change between 1996 and 1998, and they appeared to be low, the same as in food distributed in Japanese markets. The annual effective dose equivalents in adults were estimated based on the assumption that all of the imported food from Russia was consumed by Japanese people. It was assumed that the amount of intake of each food was 0.5% and that the {sup 137}Cs dose conversion factor was 1.4 x 10 - 5 mSv/Bq. The intake of {sup 134}Cs was assumed to be zero. The results of the estimations were an annual effective dose equivalent of 0.28 x 10-3 {mu}Sv for fish/shellfish, of 2.8 x 10-3 {mu}Sv for dried bracken, and of 11.9 x 10-3 {mu}Sv for dried kabanoanatake. These results overestimated actual intake, and these

  20. Measurements of indoor gamma radiation and radon concentrations in dwellings of Riyadh city, Saudi Arabia

    Energy Technology Data Exchange (ETDEWEB)

    Al-Saleh, Ferdoas S. [Physics Department, Girls College of Education in Riyadh, P.O. Box 27329, Riyadh 11417 (Saudi Arabia)]. E-mail: ferdoasalsaleh@hotmail.com

    2007-07-15

    Indoor gamma radiation measurement at dwellings of Riyadh city in Saudi Arabia using TLD has been performed. Measurements were carried out from October 2004 to June 2005. The city was divided into five sectors, for four categories of bed rooms, living rooms, bathrooms and kitchens. The indoor gamma annual absorbed dose of Riyadh city is in the range from 303{+-}57 to 700{+-}38 {mu}Gy y{sup -1} with an average value of 455.1{+-}45 {mu}Gy y{sup -1}. The calculated corresponding annual effective dose to the adult population of the locations will vary from 212{+-}40 to 490{+-}27 {mu}Sv y{sup -1} with an average value of 318.57{+-}31 {mu}Sv y{sup -1}.{sup 222}Rn concentration was measured at dwellings of Riyadh city in Saudi Arabia to estimate effective annual dose to the public from {sup 222}Rn and its progeny. The {sup 222}Rn concentrations were measured using CR-39 detector. The range of annual mean {sup 222}Rn concentrations for all sites was 2-69 Bq m{sup -3} with an average of 18.4 Bq m{sup -3}. The effective annual dose was estimated to be 0.46 mSv y{sup -1}.

  1. Suitability of digital elevation models generated by uav photogrammetry for slope stability assessment (case study of landslide in Svätý Anton, Slovakia

    Directory of Open Access Journals (Sweden)

    Rusnák Miloš

    2016-12-01

    Full Text Available Assessing the accuracy of photogrammetrically-derived digital elevation models (DEMs from UAV is essential in many geoscience disciplines. The suitability of different DEM devised for slope stability assessment was evaluated in the example of the landslide in Svätý Anton village in Slovakia. Aerial data was acquired during a one-day field campaign in autumn 2014. The point cloud from 218 images (54,607,748 points was manually classified into 7 different classes for filtering vegetation cover and buildings. Assessment of vertical differences between the UAV derived elevation model and real terrain surface was based on comparison of control points targeted by GPS (337 points and unclassified and ground classified point cloud for raster elevation models with 1, 5, 10, 20 and 50 cm pixel resolution.

  2. CT coronary angiography at an ultra-low radiation dose (<0.1 mSv): feasible and viable in times of constraint on healthcare costs

    Energy Technology Data Exchange (ETDEWEB)

    Cademartiri, Filippo [Erasmus Medical Center University, Department of Radiology, Rotterdam (Netherlands); Giovanni XXIII Clinic, Cardiovascular Imaging Unit, Monastier di Treviso (Italy); Maffei, Erica; Arcadi, Teresa [Giovanni XXIII Clinic, Cardiovascular Imaging Unit, Monastier di Treviso (Italy); Catalano, Onofrio [IRCCS, SDN Foundation, Naples (Italy); Midiri, Massimo [University of Palermo, Department of Radiology, Palermo (Italy)

    2013-03-15

    Computed tomography coronary angiography (CTCA) has reached very high standards both in terms of diagnostic performance and radiation dose reduction. This commentary follows a report on CTCA using less than 0.1 mSv in selected patients. This is an extraordinary accomplishment, both for technology and for medicine. The difficult task is now to implement this tool in clinical practice so it can play the best possible role. CTCA can improve diagnostic pathways, can save money for healthcare systems and could even improve pharmacological therapy. All of this may happen, but it will require the combined effort of all the experienced operators in this field, including the referring clinicians. In times of financial constraint, CTCA may also help to restrict ineffective medical expenses. (orig.)

  3. Maestro di Pico i iluminacije u inkunabuli De Civitate Dei (Nicolas Jenson, Venecija, 1475. u samostanu Sv. Duje u Kraju na Pašmanu

    Directory of Open Access Journals (Sweden)

    Bojan Goja

    2014-12-01

    Full Text Available U franjevačkom samostanu Sv. Duje u Kraju na otoku Pašmanu čuva se inkunabula „O državi Božjoj“ (De Civitate Dei Sv. Aurelija Augustina koju je 1475. godine u Veneciji tiskao Nicolas Jenson. Inkunabula je na f. 17 (kako je naknadno označena paginacija grafitnom olovkom, tj. stranici incipita – liber primus kao i na više drugih stranica ukrašena lijepim višebojnim iluminacijama renesansnih stilskih karakteristika izrađenih temperom, zlatnim listićima, zlatnim prahom, sepijom, tintom i akvarelom. Iluminacije f. 17 sastoje se od dva fitomorfna inicijala, dekorativnog okvira i slobodnih figurativnih prizora tj. minijatura, dok su pojedine druge stranice ukrašene fitomorfnim i brojnim inicijala tipa littera notabilior visine dva retka izrađenima u crvenoj ili plavoj boji. Dekorativni ornamentirani okvir zaključen trolistima ispunjava gornju i lijevu marginu početne stranice. Osnovu dekoracije čini traka sastavljena od pet tankih linija koja se spiralno povija i tvori kružnice koje su ispunjene cvjetovima, listovima i bobicama u plavoj i zelenoj boji i boji ciklame te stiliziranim zlatnim cvjetovima čička (lat. Arctium lappa; pojedini autori nazivaju ove ukrasne motive bottoni dorati ili gold dots. U gornjem lijevom uglu okvira naslikan je češljugar. Na mjestu gdje započinje tekst lijevog stupca naslikan je unutar pravokutnog polja na zlatnoj pozadini inicijal „I“ sastavljen od fitomorfnih motiva plave, zelene i boje ciklame s osjenčanjima u različitim nijansama. Unutar dekorativnog okvira, na sredini visine inicijala, nalazi se medaljon unutar kojeg je naslikano poprsje Sv. Aurelija Augustina. Dekorativni ornamentirani okvir koji ispunjava gornju marginu ukrašen je na isti način kao i onaj uz desnu ali skromnije. Ime tiskara dodatno je naznačeno tako da je sa gornje i donje strane okvira ukrašeno sa po jednim stiliziranim zlatnim cvijetom čička sa gornje i češljugovine (lat. Dipsacus fullonum sa donje strane

  4. Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lubner, Meghan G.; Pooler, B.D.; Kitchin, Douglas R.; Kim, David H.; Munoz del Rio, Alejandro; Pickhardt, Perry J. [University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, Departments of Radiology, Madison, WI (United States); Tang, Jie [University of Wisconsin School of Medicine and Public Health, Medical Physics, Madison, WI (United States); Li, Ke; Chen, Guang-Hong [University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, Departments of Radiology, Madison, WI (United States); University of Wisconsin School of Medicine and Public Health, Medical Physics, Madison, WI (United States)

    2015-07-15

    To prospectively compare reduced-dose (RD) CT colonography (CTC) with standard-dose (SD) imaging using several reconstruction algorithms. Following SD supine CTC, 40 patients (mean age, 57.3 years; 17 M/23 F; mean BMI, 27.2) underwent an additional RD supine examination (targeted dose reduction, 70-90 %). DLP, CTDI{sub vol}, effective dose, and SSDE were compared. Several reconstruction algorithms were applied to RD series. SD-FBP served as reference standard. Objective image noise, subjective image quality and polyp conspicuity were assessed. Mean CTDI{sub vol} and effective dose for RD series was 0.89 mGy (median 0.65) and 0.6 mSv (median 0.44), compared with 3.8 mGy (median 3.1) and 2.8 mSv (median 2.3) for SD series, respectively. Mean dose reduction was 78 %. Mean image noise was significantly reduced on RD-PICCS (24.3 ± 19HU) and RD-MBIR (19 ± 18HU) compared with RD-FBP (90 ± 33), RD-ASIR (72 ± 27) and SD-FBP (47 ± 14 HU). 2D image quality score was higher with RD-PICCS, RD-MBIR, and SD-FBP (2.7 ± 0.4/2.8 ± 0.4/2.9 ± 0.6) compared with RD-FBP (1.5 ± 0.4) and RD-ASIR (1.8 ± 0.44). A similar trend was seen with 3D image quality scores. Polyp conspicuity scores were similar between SD-FBP/RD-PICCS/RD-MBIR (3.5 ± 0.6/3.2 ± 0.8/3.3 ± 0.6). Sub-milliSievert CTC performed with iterative reconstruction techniques demonstrate decreased image quality compared to SD, but improved image quality compared to RD images reconstructed with FBP. (orig.)

  5. A Multi-component Matched Filter Cluster Confirmation Tool for eROSITA: Initial Application to the RASS and DES-SV Datasets

    Energy Technology Data Exchange (ETDEWEB)

    Klein, M.; et al.

    2017-06-20

    We describe a multi-component matched filter cluster confirmation tool (MCMF) designed for the study of large X-ray source catalogs produced by the upcoming X-ray all-sky survey mission eROSITA. We apply the method to confirm a sample of 88 clusters with redshifts $0.05SV) dataset. In our pilot study, we examine all X-ray sources, regardless of their extent. Our method employs a multi-color red sequence (RS) algorithm that incorporates the X-ray count rate and peak position in determining the region of interest for followup and extracts the positionally and color weighted optical richness $\\lambda_{\\mathrm{MCMF}}$ as a function of redshift for each source. Peaks in the $\\lambda_{\\mathrm{MCMF}}$-redshift distribution are identified and used to extract photometric redshifts, richness and uncertainties. The significances of all optical counterparts are characterized using the distribution of richnesses defined along random lines of sight. These significances are used to extract cluster catalogs and to estimate the contamination by random superpositions of unassociated optical systems. The delivered photometric redshift accuracy is $\\delta z / (1+z)=0.010$. We find a well defined X-ray luminosity-$\\lambda_{\\mathrm{MCMF}}$ relation with an intrinsic scatter of $\\delta \\ln(\\lambda_\\mathrm{MCMF}| L_\\mathrm{x})=0.21$. Matching our catalog with the DES-SV redMaPPer catalog yields good agreement in redshift and richness estimates; comparing our catalog with the South Pole Telescope (SPT) selected clusters shows no inconsistencies. SPT clusters in our dataset are consistent with the high mass extension of the RASS based $\\lambda_{\\mathrm{MCMF}}$-mass relation

  6. Diurnal expression of proteins in the retina of the blind cone-rod homeobox (Crx-/- ) mouse and the 129/Sv mouse: a proteomic study.

    Science.gov (United States)

    Møller, Morten; Rath, Martin Fredensborg; Ludvigsen, Maja; Honoré, Bent; Vorum, Henrik

    2017-11-01

    The vertebrate retina contains a circadian clock participating in adaptations to day and night vision. This peripheral clock is independent of the master clock in the suprachiasmatic nucleus (SCN). The retinal clock is located in several cell types, including the photoreceptors. To investigate the role of the circadian clock of the photoreceptor cells in regulation of retinal protein rhythms, we analysed diurnal protein expression in the photoreceptor-deficient cone-rod homeobox knockout mouse (Crx-/- ) and the 129/Sv mouse. 2D gels were made from retinal homogenates of 129/Sv and Crx-/- mice killed at midday and midnight. Stained gels were analysed by use of PDQuest 2D gel analysis software. After trypsin digestion of differential expressed spots, the proteins were identified by LC-MS/MS using a nano-liquid chromatograph connected to a Q-TOF Premier mass spectrometer. These data were used to search the SWISS-PROT database. Both the retinae of the control and the Crx-/- mice exhibited diurnal proteins rhythms. As expected, proteins involved in phototransduction were not detected in the Crx-/- mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes. Data are available via ProteomeXchange with identifier PXD005556. We show diurnal protein rhythms in the retina of a mouse lacking the rods and cones. The diurnal protein rhythms in this genotype, lacking the circadian clock of the photoreceptors, might be caused by a circadian clock in other retinal cell types or a direct light input to the retina. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  7. Postnatal training of 129/Sv mice confirms the long-term influence of early exercising on the motor properties of mice.

    Science.gov (United States)

    Serradj, Najet; Jamon, Marc

    2016-09-01

    A previous study showed that motor experiences during critical periods of development durably affect the motor properties of adult C57BL/6J mice. However, dependence on early environmental features may vary with the genetic profile. To evaluate the contribution of the genetic background on external influences to motricity, we performed the same experiment in a 129/Sv mouse strain that show a strongly different motor profile. Mice were subjected to endurance training (enriched environment or forced treadmill), hypergravity (chronic centrifugation), or simulated microgravity (hindlimb unloading) between postnatal days 10 and 30. They were then returned to standard housing until testing at the age of nine months. The endurance-trained mice showed a fast-slow shift in the deep zone of the tibialis. In addition, mice reared in the enriched environment showed a modified gait and body posture, and improved performance on the rotarod, whereas forced treadmill training did not affect motor output. Hypergravity induced a fast-slow shift in the superficial zone of the tibialis, with no consequence on motor output. Hindlimb unloading provoked an increased percentage of immature hybrid fibres in the tibialis and a shift in the soleus muscle. When compared with similarly reared C57BL/6J mice, 129/Sv mice showed qualitative differences attributable to the lower efficiency of early training due to their lower basal motor activity level. Nevertheless, the results are essentially consistent in both strains, and support the hypothesis that early motor experience influences the muscle phenotype and motor output. Copyright © 2016. Published by Elsevier B.V.

  8. Current concentration of artificial radionuclides and estimated radiation doses from 137Cs around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki.

    Science.gov (United States)

    Taira, Yasuyuki; Hayashida, Naomi; Brahmanandhan, Gopalganapathi M; Nagayama, Yuji; Yamashita, Shunichi; Takahashi, Jumpei; Gutevitc, Alexander; Kazlovsky, Alexander; Urazalin, Marat; Takamura, Noboru

    2011-01-01

    To evaluate current environmental contamination and contributions from internal and external exposure due to the accident at the Chernobyl Nuclear Power Plant (CNPP) and nuclear tests at the Semipalatinsk Nuclear Testing Site (SNTS), concentrations of artificial radionuclides in edible mushrooms, soils and stones from each area were analyzed by gamma spectrometry. Annual effective doses were calculated for each area from the cesium contamination. Calculated internal effective doses of (137)Cs due to ingestion of mushrooms were 1.8 × 10(-1) mSv/year (y) in Gomel city (around CNPP), 1.7 × 10(-1) mSv/y in Korosten city (around CNPP), 2.8 × 10(-4) mSv/y in Semipalatinsk city, and 1.3 × 10(-4) mSv/y in Nagasaki. Calculated external effective doses of (137)Cs were 3.4 × 10(-2) mSv/y in Gomel city, 6.2 × 10(-2) mSv/y in Korosten city, 2.0 × 10(-4) mSv/y in Semipalatinsk city, and 1.3 × 10(-4) mSv/y in Nagasaki. Distribution of radionuclides in stones collected beside Lake Balapan (in SNTS) were (241)Am (49.4 ± 1.4 Bq/kg), (137)Cs (406.3 ± 1.7 Bq/kg), (58)Co (3.2 ± 0.5 Bq/kg), and (60)Co (125.9 ± 1.1 and 126.1 ± 1.1 Bq/kg). The present study revealed that dose rates from internal and external exposure around CNPP were not sufficiently low and radiation exposure potency still exists even though current levels are below the public dose limit of 1 mSv/y (ICRP1991). Moreover, parts of the SNTS area may be still contaminated by artificial radionuclides derived from nuclear tests. Long-term follow-up of environmental monitoring around CNPP and SNTS, as well as evaluation of health effects in the population residing around these areas, may contribute to radiation safety with a reduction of unnecessary exposure of residents.

  9. Final report of evaluation of dose and measurement of radon concentration

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    A mean annual exposure to radon daughters in indoor air was estimated on the basis of measurement of radon concentration in indoor air in Japan from fiscal 1992 to 1996. Doses were estimated by UNSCEAR method. The representative values in this report show the mean values in whole Japan. Each dose in the local area was different reflecting the different concentration of radon daughters. However, the same parameters were used in each area. When mean annual dose of radon daughters was estimated, we used 15.5 Bq m{sup -3} mean annual exposure to radon daughters in indoor air, 5 Bq m{sup -3} that in outdoor air, 0.4 the equilibrium factor indoor, 0.6 the equilibrium factor outdoor and 0.9 of P. The model of UNSCEAR based on these above values gave 0.46 mSv y{sup -1} mean annual dose of radon daughters which were consisted of from 0.38 mSv y{sup -1} in Kanto district to 0.52 mSv y{sup -1} Kyushu, Okinawa district. (S.Y.)

  10. 210Po concentration analysis on tobacco and cigarettes in Malaysia

    Science.gov (United States)

    Azman, Muhammad Azfar; Rahman, Irman Abdul; Yasir, Muhammad Samudi

    2013-05-01

    Tobacco or better known as the cigarette was smoked since ages. Although many efforts had been made by the Ministry of Health to prevent or reduce the cigarette problem, the smokers still consider that cigarette are not harmful to health. This work is conducted to study the concentration of radionuclides alpha in tobacco and tobacco products in Malaysia. The radionuclide sought in this study is 210Po which is an alpha emitter. The sample used are tobacco and cigarettes, the tobacco samples were taken from tobacco farms in Malaysia while the sample branded cigarettes Marlboro and Gudang Garam were bought in the supermarket. The objectives of this study are to determine the concentration of radionuclides 210Po in tobacco and tobacco products as well as to estimate the radioactivity doses contributing to the smokers in Malaysia. The results for Marlboro cigarettes and Gudang Garam were found to be on the average radionuclide concentration of 210Po is 13.3 mBq/g (Marlboro cigarettes) and 11.9 mBq/g (Gudang Garam). From the total concentration of the cigarette, the estimated annual contribution dose to smokers for every 20 cigarettes smoked per day are 111.9 ± 14.7 μSv/year for Marlboro cigarettes and 100.2 ± 3.3 μSv/year for Gudang Garam cigarettes. The average concentration of radionuclides for tobacco leaf tobacco for each area taken is 3.6 mBq / g for Bachok, 2.4 mBq / g for Tumpat and 3.1 mBq / g for Semerak district.

  11. Improving the validity of peripheral venous blood gas analysis as an estimate of arterial blood gas by correcting the venous values with SvO₂.

    Science.gov (United States)

    Lemoël, Fabien; Govciyan, Sandra; El Omri, Mouna; Marquette, Charles-Hugo; Levraut, Jacques

    2013-03-01

    Peripheral venous blood gas (pVBG) analysis in replacement of arterial blood gas (ABG) is limited by the unpredictable differences between arterial and venous values, especially for PCO2 and pH (ΔPCO2 and ΔpH). We hypothesized that, using the theoretical relationship linking SvO2 and blood flow, we could diminish the effect of local circulatory conditions on ΔPCO2 and ΔpH and thereby increase pVBG validity. This was a prospective cross-sectional study performed in emergency patients requiring a blood gas analysis in which ABG and pVBG were performed simultaneously. The data of 50 randomly selected patients (model group) were used for developing two equations to correct PvCO2 and pHv according to the peripheral SvO2 (SpvO2) level. The formulas derived were PvCO2cor = PvCO2 - 0.30 × (75 - SpvO2), and pHvcor = pHv + 0.001 × (75 - SpvO2). The validity of the corrected values was then tested on the remaining population (validation group). There were 281 patients included in the study, mainly for dyspnea. ΔPCO2 and ΔpH were strongly correlated with SpvO2 (r(2) = 0.62 and r(2) = 0.53, respectively, p 45 mm Hg (AUC ROC = 0.96 ± 0.01 vs. 0.89 ± 0.02, p 7.45 (AUC = 0.91 ± 0.02 vs. 0.81 ± 0.04, p < 0.001). The variability of ΔPCO2 and ΔpH is significantly lowered when the venous values are corrected according to the SpvO2 value, and pVBG is therefore more accurate and valid for detecting an arterial abnormality. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Returning Home to the Advaitic Self: Svāmī Rāma Tīrtha and His American Audiences

    Directory of Open Access Journals (Sweden)

    Ankur Barua

    2016-12-01

    Full Text Available A recurring theme in the Advaita Vedānta traditions is the necessity of empirical purification through means such as the cultivation of virtues, the study of the Vedas, and so on, even though the transcendental self has never been subject to any form of bondage. The traditions seek to mitigate this paradox by employing the vocabulary of a shift across the ‘levels’ of truth—while the worldly self is, empirically speaking, moving towards the goal of realization, from the transcendental perspective, the self never loses its eternal nature. We will explore how Svāmī Rāma Tīrtha (1873–1906 addressed this theme of the recovery of one’s essential self in his lectures to some American audiences between 1902 and 1904. Drawing on some of the vocabularies of Swami Vivekananda, who had presented a ‘Practical Vedānta’ to Western audiences in the late 1890s, Rāma Tīrtha developed an Advaitic form of self-realization that is practically engaged with the world and, according to him, is the spiritual quest of humanity across all boundaries.

  13. First molecular data and the phylogenetic position of the millipede-like centipede Edentistoma octosulcatum Tömösváry, 1882 (Chilopoda: Scolopendromorpha: Scolopendridae.

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    Varpu Vahtera

    Full Text Available Edentistoma octosulcatum Tömösváry, 1882, is a rare, superficially millipede-like centipede known only from Borneo and the Philippines. It is unique within the order Scolopendromorpha for its slow gait, robust tergites, and highly modified gizzard and mandible morphology. Not much is known about the biology of the species but it has been speculated to be arboreal with a possibly vegetarian diet. Until now its phylogenetic position within the subfamily Otostigminae has been based only on morphological characters, being variably ranked as a monotypic tribe (Arrhabdotini or classified with the Southeast Asian genus Sterropristes Attems, 1934. The first molecular data for E. octosulcatum sourced from a newly collected specimen from Sarawak were analysed with and without morphology. Parsimony analysis of 122 morphological characters together with two nuclear and two mitochondrial loci resolves Edentistoma as sister group to three Indo-Australian species of Rhysida, this clade in turn grouping with Ethmostigmus, whereas maximum likelihood and parsimony analyses of the molecular data on their own ally Edentistoma with species of Otostigmus. A position of Edentistoma within Otostigmini (rather than being its sister group as predicted by the Arrhabdotini hypothesis is consistently retrieved under different analytical conditions, but support values within the subfamily remain low for most nodes. The species exhibits strong pushing behaviour, suggestive of burrowing habits. Evidence against a suggested vegetarian diet is provided by observation of E. octosulcatum feeding on millipedes in the genus Trachelomegalus.

  14. PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

    Science.gov (United States)

    Hu, Meng; Yuan, Shuofeng; Ye, Zi-Wei; Singh, Kailash; Li, Cun; Shuai, Huiping; Fai, Ng; Chow, Billy K C; Chu, Hin; Zheng, Bo-Jian

    2017-03-01

    Substitutions in the PA N-terminus (PAN) of influenza A viruses are associated with viral pathogenicity. During our previous study, which identified PAN-V63I and -A37S/I61T/V63I/V100A substitutions as virulence determinants, we observed a severe decrease in virus growth and transcription/replication capacity posed by PAN-A37S/V100A substitution. To further delineate the significance of substitutions at these positions, we generated mutant H7N7 viruses bearing the substitutions PAN-A37S, -A37S/I61T, -A37S/V63I, -V100A, -I61T/V100A and -V63I/V100A by reverse genetics. Our results showed that all mutant viruses except PAN-V100A showed a significantly reduced growth capability in infected cells. At the same time, the PAN-A37S, -A37S/I61T and -A37S/V63I mutant viruses displayed decreased viral transcription and replication by diminishing virus RNA synthesis activity. Biochemical assays indicated that the substitutions PAN-A37S, -A37S/I61T and -A37S/V63I suppressed the polymerase and endonuclease activities when compared with those of the wild-type. Together, our results demonstrated that the PAN-A37S, -A37S/I61T and -A37S/V63I substitutions contributed to a decreased pathogenicity of avian H7N7 influenza A virus.

  15. Radionuclide concentrations in samples of medicinal herbs and effective dose from ingestion of ¹³⁷Cs and natural radionuclides in herbal tea products from Serbian market.

    Science.gov (United States)

    Jevremovic, Milutin; Lazarevic, Natasa; Pavlovic, Snezana; Orlic, Milan

    2011-03-01

    The objective of this study is to evaluate natural and artificial radioactivity levels in 18 different samples of medicinal herbs from Serbian market. The activity concentrations of (238)U, (232)Th, (40)K, and (137)Cs were measured using gamma spectroscopy system with a high-purity germanium detector. The activity concentrations of (238)U, (232)Th, (40)K, and (137)Cs were found to be in a range of 0.6-8.2, 1.7-15.1, 126-1243.7, and 0.3-8.8 Bq/kg, respectively. The annual whole body doses from ingestion of (137)Cs and natural radionuclides for an adult person who consumed herbal tea from these medicinal herbs were found to be 2.5-469.9 nSv for (137)Cs, 0.7-9.7 nSv for (238)U, 0.3-2.8 nSv for (232)Th, and 1026.0-10,132.0 nSv for (40)K. These doses are not hazardous to public health. The obtained results were compared with correspondent studies conducted worldwide.

  16. Carbon nanotube IR detectors (SV)

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, F. L.

    2012-03-01

    Sandia National Laboratories (Sandia) and Lockheed Martin Corporation (LMC) collaborated to (1) evaluate the potential of carbon nanotubes as channels in infrared (IR) photodetectors; (2) assemble and characterize carbon nanotube electronic devices and measure the photocurrent generated when exposed to infrared light;(3) compare the performance of the carbon nanotube devices with that of traditional devices; and (4) develop and numerically implement models of electronic transport and opto-electronic behavior of carbon nanotube infrared detectors. This work established a new paradigm for photodetectors.

  17. Measurement of radon concentration in old metalliferous mines in San Luis, Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Anjos, Roberto M.; Lacerda, Tiago; Rosas, Juan P. de [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/no, Gragoata, 24210-346, Niteroi, RJ (Brazil); Da Silva, Almy A.R. [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/no, Gragoata, 24210-346, Niteroi, RJ (Brazil); Instituto de Fisica, Universidade de Sao Paulo, P. O. Box 66318, 05314-970, Sao Paulo, SP (Brazil); Rizzotto, Marcos; Valladares, Diego L.; Velasco, Hugo [GEA, Instituto de Matematica Aplicada San Luis (IMASL), Universidad Nacional de San Luis, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ej. de los Andes 950, D5700HHW San Luis (Argentina); Yoshimura, Elisabeth M. [Instituto de Fisica, Universidade de Sao Paulo, P. O. Box 66318, 05314-970, Sao Paulo, SP (Brazil)

    2014-07-01

    Radon levels in two old mines in San Luis, Argentina, were measured and analyzed. La Carolina gold mine and Los Condores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, high concentration values of {sup 222}Rn were observed in summer and low values in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Condores mine. The radiation dose and environmental health risk of {sup 222}Rn concentrations to both guides and visitors were estimated for both seasons and compared with dose and action level values recommended by the International Commission on Radiological Protection (ICRP). The radon contribution to the effective dose rate for visitors has been previously assessed for the warm season. The values are 0.38±0.07 mSv y{sup -1} and 0.05±0.02 mSv y{sup -1} for La Carolina and Los Condores, respectively. These values were obtained assuming an accumulated annual time underground of 20 h. For the guides these values are 11±2 mSv y{sup -1} and 1.45±0.5 mSv y{sup -1} for La Carolina and Los Condores, respectively, assuming an accumulated annual time underground of 600 h. The occupational dose rate limit suggested by the ICRP is 20 mSv y{sup -1}. As these values indicate the dose is an order of magnitude lower in Los Condores than La Carolina mine. This is because this mine, due to its characteristics, is more ventilated than La Carolina mine. This is important because actions can be taken to lower the radon accumulation in La Carolina gold mine, for example by opening new ducts to increase air circulation. Finally, in this work, seasonal variations of the dose rate are assessed and

  18. Kontextus(ok a grammatikalizációs jelentésváltozás irodalmában

    Directory of Open Access Journals (Sweden)

    Katalin Nagy C.

    2014-12-01

    Full Text Available Jelen írás a történeti pragmatika, ezen belül a grammatikalizációs jelentésváltozással foglalkozó kutatások kontextusfogalmának feltárását tűzi ki célul. E kutatási terület két kontextustipológiájának (Heine 2002 és Diewald 2002 feltételezett kontextustípusai közül a kritikus kontextus (Diewald 2002 jellegzetességeinek alapos feltárása alapján az a konklúzió vonható le, hogy a kontextus kifejezés a vizsgált kutatási terület szakirodalmában nem mindig az értelmezés kontextusaként értendő. Egyrészt, a kontextus fogalma a grammatikalizációs jelentésváltozás szakirodalmában szűkebb fogalom az értelmezés kontextusánál, abban csupán a folyamatot előmozdító kontextuális tényezők kapnak szerepet. Másrészt, a történeti kutató értelmezési kontextusában több kontextuális tényező és másképp játszik/játszhat szerepet, mint a mindennapi nyelvhasználatban a megnyilatkozások értelmezése során. Harmadrészt, a kontextusnak a történeti kutatásban használatos fogalma a nyelvi megértésben szerepet játszó kontextus és a módszertani értelemben vett kontextus vonásainak keveredését mutatja. The present paper aims to discuss the notion of context as it appears in historical pragmatics, and, especially, in research concerning semantic change in grammaticalization. It presents the context types provided in Heine (2002 and Diewald (2002, which are supposed to be important in semantic change in grammaticalization. After discussing the characteristics of critical context, proposed in Diewald’s (2002 typology, the paper highlights why the expression context as used in grammaticalization literature cannot be understood as the context of online utterance interpretation. First, this notion of context is narrower than the context of online language processing in the sense that it contains only those contextual features which are important in semantic change. Second, the context

  19. Sensitivity of clear-sky direct radiative effect of the aerosol to micro-physical properties by using 6SV radiative transfer model: preliminary results

    Science.gov (United States)

    Bassani, Cristiana; Tirelli, Cecilia; Manzo, Ciro; Pietrodangelo, Adriana; Curci, Gabriele

    2015-04-01

    The aerosol micro-physical properties are crucial to analyze their radiative impact on the Earth's radiation budget [IPCC, 2007]. The 6SV model, last generation of the Second Simulation of a Satellite Signal in the Solar Spectrum (6S) radiative transfer code [Kotchenova et al., 2007; Vermote et al., 1997] has been used to perform physically-based atmospheric correction of hyperspectral airborne and aircraft remote sensing data [Vermote et al., 2009; Bassani et al. 2010; Tirelli et al., 2014]. The atmospheric correction of hyperspectral data has been shown to be sensitive to the aerosol micro-physical properties, as reported in Bassani et al., 2012. The role of the aerosol micro-physical properties on the accuracy of the atmospheric correction of hyperspectral data acquired over water and land targets is investigated within the framework of CLAM-PHYM (Coasts and Lake Assessment and Monitoring by PRISMA HYperspectral Mission) and PRIMES (Synergistic use of PRISMA products with high resolution meteo-chemical simulations and their validation on ground and from satellite) projects, both funded by Italian Space Agency (ASI). In this work, the results of the radiative field of the Earth/Atmosphere coupled system simulated by using 6SV during the atmospheric correction of hyperspectral data are presented. The analysis of the clear-sky direct radiative effect is performed considering the aerosol micro-physical properties used to define the aerosol model during the atmospheric correction process. In particular, the AERONET [Holben et al., 1998] and FLEXAOD [Curci et al., 2014] micro-physical properties are used for each image to evaluate the contribution of the size distribution and refractive index of the aerosol type on the surface reflectance and on the direct radiative forcing. The results highlight the potential of the hyperspectral remote sensing data for atmospheric studies as well as for environmental studies. Currently, the future hyperspectral missions, such as the

  20. Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells.

    Science.gov (United States)

    Stegajev, Vasili; Kouri, Vesa-Petteri; Salem, Abdelhakim; Rozov, Stanislav; Stark, Holger; Nordström, Dan C E; Konttinen, Yrjö T

    2014-12-01

    Apoptosis is involved in the pathogenesis of Sjögren's syndrome (SS), an autoimmune disease affecting exocrine glands. Our recent studies revealed diminished histamine H4 receptor (H₄R) expression and impaired histamine transport in the salivary gland epithelial cells in SS. The aim was now to test if nanomolar histamine and high-affinity H₄R signaling affect apoptosis of human salivary gland epithelial cell. Simian virus 40-immortalized acinar NS-SV-AC cells were cultured in serum-free keratinocyte medium ± histamine H₄R agonist HST-10. Expression and internalization of H₄R were studied by immunofluorescence staining ± clathrin inhibitor methyl-β-cyclodextrin (MβCD). Apoptosis induced using tumor necrosis factor-α with nuclear factor-κB inhibitor IMD-0354 was studied using phase contrast microscopy, Western blot, flow cytometry and polymerase chain reaction (qRT-PCR). HST-10-stimulated H₄R internalization was inhibited by MβCD. Western blotting revealed diminished phosphorylated c-Jun N-terminal kinase JNK, but unchanged levels of phosphorylated extracellular signal regulated kinase pERK1/2 in H₄R-stimulated samples compared to controls. qRT-PCR showed up-regulated expression of anti-apoptotic B cell lymphoma-extra large/Bcl-xL mRNAs and proteins, whereas pro-apoptotic Bcl-2-associated X protein/BAX remained unchanged in H4R-stimulated samples. H₄R stimulation diminished cleavage of PARP and flow cytometry showed significant dose-dependent inhibitory effect of H₄R stimulation on apoptosis. As far as we know this is the first study showing inhibitory effect of H₄R activation on apoptosis of human salivary gland cells. Diminished H₄R-mediated activation may contribute to loss of immune tolerance in autoimmune diseases and in SS in particular.

  1. Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross.

    Science.gov (United States)

    Chesler, Elissa J; Plitt, Aaron; Fisher, Daniel; Hurd, Benita; Lederle, Lauren; Bubier, Jason A; Kiselycznyk, Carly; Holmes, Andrew

    2012-06-01

    Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and is a predictor of alcohol abuse. Previous studies have shown that the C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mouse strains differ in responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, we performed quantitative trait locus (QTL) analysis of measures of EtOH-induced ataxia (accelerating rotarod), hypothermia, and loss of righting reflex (LORR) duration in a B6×S1 F2 population. We confirmed that S1 showed greater EtOH-induced hypothermia (specifically at a high dose) and longer LORR compared to B6. QTL analysis revealed several additive and interacting loci for various phenotypes, as well as examples of genotype interactions with sex. QTLs for different EtOH phenotypes were largely non-overlapping, suggesting separable genetic influences on these behaviors. The most compelling main-effect QTLs were for hypothermia on chromosome 16 and for LORR on chromosomes 4 and 6. Several QTLs overlapped with loci repeatedly linked to EtOH drinking in previous mouse studies. The architecture of the traits we examined was complex but clearly amenable to dissection in future studies. Using integrative genomics strategies, plausible functional and positional candidates may be found. Uncovering candidate genes associated with variation in these phenotypes in this population could ultimately shed light on genetic factors underlying sensitivity to EtOH intoxication and risk for alcoholism in humans.

  2. Simvastatin and intracellular pH regulation by the Na+/H+ antiport of SV40-virus-transformed human MRC5 fibroblasts.

    Science.gov (United States)

    Davies, J E; Ng, L L

    1993-06-01

    1. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by simvastatin leads to inhibition of both cell growth and Na+/H+ antiport activity. The effect of simvastatin on intracellular pH and Na+/H+ antiport activity was therefore studied on an adherent cell line, the SV40-virus-transformed MRC5 human fibroblast. 2. Simvastatin led to a dose-dependent decrease in intracellular pH, attributed to a reduction in Na+/H+ exchange, together with a rounding of cell shape. Mevalonate (1 mmol/l) prevented these effects of simvastatin, and when added after inhibition of the antiport by simvastatin, reversed these changes within 1-2h. 3. The phenomenon of mevalonate reversal of antiport inhibition by simvastatin was not sensitive to cycloheximide, indicating its post-translational nature. This was also consistent with the short period of incubation with mevalonate leading to reversal of antiport inhibition (1-2 h). These changes in intracellular pH regulation were not due to alterations in cell cholesterol content. 4. A variety of inhibitors of post-translational processes, such as N-linked glycosylation (tunicamycin), phosphorylation (staurosporine), isoprenylation (farnesol, limonene), and of pertussis-toxin-sensitive G-proteins or calmodulin (W7), had no effect on the reversal by mevalonate of simvastatin-induced changes in Na+/H+ antiport activity. 5. N-Ethylmaleimide (50 mumol/l for 5 min) prevented mevalonate reversing the effects of simvastatin, suggesting the importance of thiol groups in the phenomenon of reversal of the inhibition of Na+/H+ antiport activity by simvastatin. Furthermore, concurrent incubation of simvastatin-treated cells with dithiothreitol (1 mmol/l) and N-ethylmaleimide restored the ability of mevalonate to reverse the inhibitory effects of simvastatin on Na+H+ antiport activity.

  3. Geophysical fingerprints of shallow cultural structures from microgravity and GPR measurements in the Church of St. George, Svätý Jur, Slovakia

    Science.gov (United States)

    Panisova, Jaroslava; Murín, Igor; Pašteka, Roman; Haličková, Jana; Brunčák, Peter; Pohánka, Vladimír; Papčo, Juraj; Milo, Peter

    2016-04-01

    Recording of the historic edifice using the state-of-the-art geodetic and geophysical techniques brings easier visualisation in form of a three-dimensional (3D) model, thus allowing better understanding of its historical construction by the public and non-experts. We have applied this approach at the Church of St. George, one of the most significant religious buildings in south-western Slovakia, which dominates a silhouette of the town Svätý Jur. The geodetic survey allowed to record the actual state of the church. The church exterior was surveyed using a total station. Due to the intricate shape of the interior components of the church, it was decided to use a terrestrial laser scanner to generate the point cloud data, which were processed into floor plan, elevations, sectional 2D drawings and 3D model. The geophysical survey was carried out in the interior of the church in order to identify potential subsurface anthropogenic structures. Microgravity and ground penetrating radar (GPR) methods were selected as the most effective geophysical tools for such task. In microgravity data processing we focused on the calculation and removal of the gravitational effects of the building masses. The main negative gravity anomalies of interest in the nave, which also have been confirmed by GPR measurements, are interpreted as medieval crypts. Another very important outcome of the geophysical survey is the discovery of the west wall foundations of the oldest Romanesque construction. From each geophysical data acquired we derived 3D polygonal models, which are compared to achieve more realistic picture of the subsurface structures. Verification of these structures by means of archaeological excavation has not been carried out yet.

  4. Assessment of chicken protection against Campylobacter jejuni infection by immunization with avirulent Salmonella enterica sv. Typhimurium strain producing Campylobacter CjaD/Pal protein

    Directory of Open Access Journals (Sweden)

    Łaniewski P

    2012-08-01

    Full Text Available Pawel Laniewski,1 Malgorzata Lis,2 Agnieszka Wyszynska,1 Pawel Majewski,3 Renata Godlewska,1 Elzbieta Katarzyna Jagusztyn-Krynicka11Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland; 2Biowet Pulawy Ltd, Pulawy, Poland; 3Department of Vertebrate Physiology, Institute of Zoology, Faculty of Biology, University of Warsaw, Warsaw, PolandAbstract: Campylobacter jejuni is a major food-borne pathogen, causing gastroenteritis worldwide. Chickens are considered to be one of the most common sources of human C. jejuni infection in developed countries. Campylobacter CjaD/Pal protein (annotated as Cj0113 in C. jejuni strain NCTC11168 is a highly immunogenic, membrane-located antigen, conserved among different strains, with the potential to provide broad protection against C. jejuni colonization. The present study examines the immunogenicity and the general efficacy of avirulent S. enterica sv. Typhimurium Δcrp Δcya expressing C. jejuni CjaD as a chicken vaccine against Campylobacter colonization. The high copy number plasmid pYA3341 Asd+ was used as a cloning vector. Here, 1- and 14-day old chickens were orally immunized with a delivery vector strain, expressing C. jejuni CjaD. Two weeks later, they were challenged with a wild-type C. jejuni strain isolated from chicken carcasses. This schedule of immunization induced significant levels of serum-specific IgG as well as mucosal intestinal sIgA as measured by ELISA tests using Campylobacter membrane proteins as a coating antigen. Nevertheless, protection experiments did not result in significant reduction of colonization of vaccinated birds relative to nonvaccinated birds.Keywords: Campylobacter, cjaD, immunization, Pal

  5. Social investigation and long-term recognition memory performance in 129S1/SvImJ and C57BL/6JOlaHsd mice and their hybrids.

    Directory of Open Access Journals (Sweden)

    Jana Hädicke

    Full Text Available When tested for their behavioural performance, the mixed genetic background of transgenic mice is a critical, but often ignored, issue. Such issues can arise because of the significant differences in defined behavioural parameters between embryonic stem cell donor and recipient strains. In this context, the commonly used stem cell donor strain '129' shows 'deficits' in different paradigms for learning and long-term memory. We investigated the long-term social recognition memory performance and the investigative behaviour in commercially available 129S1/SvImJ and C57BL/6JOlaHsd mice and two F1-hybrids (129S1/SvImJ×C57BL/6JOlaHsd by using the social discrimination procedure and its modification, the volatile fraction cage (VFC. Our data revealed an unimpaired olfactory long-term recognition memory not only in female and male 129S1/SvImJ and C57BL/6JOlaHsd mice but also in the two hybrid lines (129S1/SvImJxC57BL/6JOlaHsd when the full 'olfactory signature' of the 'to-be-recognized' conspecific was presented. Under these conditions we also failed to detect differences in the long-term recognition memory between male and female mice of the tested strains and revealed that the oestrus cycle did not affect the performance in this memory task. The performance in the VFC, based only on the volatile components of the 'olfactory signature' of the 'to-be-recognized' conspecific, was similar to that observed under direct exposure except that females of one F1 hybrid group failed to show an intact long-term memory. Thus, the social discrimination procedure allowing direct access between the experimental subject and the stimulus animal(s is highly suitable to investigate the impact of genetic manipulations on long-term memory in male and female mice of the strain 129S1/SvImJ, C57BL/6JOlaHsd and 129S1/SvImJxC57BL/6JOlaHsd hybrids.

  6. 210Po and 210Pb Activity Concentrations in Cigarettes Produced in Vietnam and Their Estimated Dose Contribution Due to Smoking

    Science.gov (United States)

    Tran, Thuy-Ngan N.; Le, Cong-Hao; Chau, Van-Tao

    Smoking cigarettes contributes significantly to the increase of radiation in human body because 210Po and 210Pb exist relatively high in tobacco leaves. Therefore, these two radioisotopes in eighteen of the most frequently sold cigarette brands produced in Vietnam were examined in this study. 210Po was determined by alpha spectroscopy using a passivated implanted planar silicon (PIPS) detector after a procedure including radiochemical separation and spontaneous deposition of polonium on a copper disc (the deposition efficiency of 210Po on a copper disc was approximately 94%). Sequentially, 210Pb was determined through the ingrowth of 210Po after storing the sample solutions for approximately six months. The activity concentrations of 210Po in cigarettes ranged from 13.8 to 82.6 mBq/cigarette (the mean value was 26.4 mBq/cigarette) and the activity concentrations of 210Pb in cigarettes ranged from 13.9 to 78.8 mBq/cigarette (the mean value was 25.8 mBq/cigarette). The annual committed effective dose for smokers who smoke one pack per day was also estimated to be 295.4 µSv/year (223.0 µSv/year and 72.4 µSv/year from 210Po and 210Pb, respectively). These indicated that smoking increased the risk of developing lung cancer was approximately 60 times greater for smokers than for non-smokers.

  7. Purification and characterization of two high molecular mass snake venom metalloproteinases (P-III SVMPs), named SV-PAD-2 and HR-Ele-1, from the venom of Protobothrops elegans (Sakishima-habu).

    Science.gov (United States)

    Oyama, Etsuko; Takahashi, Hidenobu

    2015-09-01

    We herein identified two high molecular mass metalloproteinases, named SV-PAD-2 and HR-Ele-1, in the venom of Protobothrops elegans. HR-Ele-1 appeared as a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) regard under reducing and non-reducing conditions, and the molecular mass of this protease was approximately 60 kDa under reducing conditions. On the other hand, the molecular masses of SV-PAD-2 on SDS-PAGE were 110 kDa under the non-reducing condition and 52 kDa under the reducing condition. These SVMPs exhibited fibrinogenolytic and enzymatic activities against synthetic substrates for matrix metalloproteinases (MMPs) and the insulin B-chain, and were both inhibited by EDTA. SV-PAD-2 inhibited ADP- and collagen-induced platelet aggregation, with IC50 values of 240 nM and 185 nM, respectively. HR-Ele-1 exhibited hemorrhagic activity, and its minimum hemorrhagic dose (MHD) was 0.05 μg in the guinea pig. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Faraona dievišķās varas manifestācija Ozīrisa un Hora svētkos 1872.-30.g.p.m.ē

    OpenAIRE

    Andrejauska, Ieva

    2012-01-01

    Bakalaura darba „Faraona dievišķās varas manifestācija Ozīrisa un Hora svētkos 1872. - 30. g.p.m.ē.” mērķis ir apskatīt konkrēto svētku ceremonijas ar faraona klātbūtni un izpētīt, kā caur rituāliem tiek leģitimēta dievišķā vara. Senās Ēģiptes valdniekam piemita dievišķa vara, ko noteiktā laikā bija nepieciešams atjaunot, stiprināt, leģitimēt. Tas bija iespējams Ozīrisa un Hora svētku ceremonijās, kuru laikā faraons veica ar Ozīrisa mitoloģiju saistītus rituālus. Pētījuma gaitā noskaidrots, ...

  9. Solvent effect on the fluorescence quenching of biologically active carboxamide by aniline and carbon tetrachloride in different solvents using S-V plots

    Energy Technology Data Exchange (ETDEWEB)

    Patil, N.R. [Department of Physics, B V B College of Engineering and Technology, Hubli 580031, Karnataka (India); Melavanki, R.M., E-mail: melavanki73@gmail.com [Department of Physics, M S Ramaiah Institute of Technology, Bangalore 560054, Karnataka (India); Kapatkar, S.B. [Department of Physics, B V B College of Engineering and Technology, Hubli 580031, Karnataka (India); Chandrasekhar, K. [Department of Physics, Basaveshwar Engineering College, Bagalkot 587101, Karnataka (India); Ayachit, N.H. [Department of Physics, B V B College of Engineering and Technology, Hubli 580031, Karnataka (India); Umapathy, Siva [Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka (India)

    2012-03-15

    The fluorescence quenching studies of carboxamide namely (E)-N-(3-Chlorophenyl)-2-(3,4,5-trimethoxybenzylideneamino)-4,5,6,7 tetrahydrobenzo[b]thiophene-3-carboxamide [ENCTTTC] by aniline and carbon tetrachloride in six different solvents namely toluene, cyclohexane, n-hexane, n-heptane, n-decane and n-pentane have been carried out at room temperature with a view to understand the quenching mechanisms. The Stern-Volmer (S-V) plots have been found to be non-linear with a positive deviation for all the solvents studied. In order to interpret these results we have invoked the ground state complex formation and sphere of action static quenching models. Using these models various quenching rate parameters have been determined. The magnitudes of these parameters suggest that sphere of action static quenching model agrees well with the experimental results. Hence the positive deviation is attributed to the static and dynamic quenching. Further, with the use of Finite Sink approximation model, it was possible to check these bimolecular reactions as diffusion-limited and to estimate independently distance parameter R Prime and mutual diffusion coefficient D. Finally an effort has been made to correlate the values of R Prime and D with the values of the encounter distance R and the mutual coefficient D determined using the Edward's empirical relation and Stokes Einstein relation. - Highlights: Black-Right-Pointing-Pointer Stern-Volmer plots show positive deviation, indicating efficient fluorescence quenching. Black-Right-Pointing-Pointer Static quenching constant 'V' and kinetic distance 'r' are in agreement with literature values. Black-Right-Pointing-Pointer Values of k{sub q} are greater than 4{pi}N Prime R Prime D, which is expected result for diffusion limited reaction. Black-Right-Pointing-Pointer Finite sink approximation model is valid in recovering the parameters D and R Prime (R). Black-Right-Pointing-Pointer Quenching reaction is diffusion

  10. Concentration of (3)H in plants around Fukushima Dai-ichi Nuclear Power Station.

    Science.gov (United States)

    Kakiuchi, Hideki; Akata, Naofumi; Hasegawa, Hidenao; Ueda, Shinji; Tokonami, Shinji; Yamada, Masatoshi; Hosoda, Masahiro; Sorimachi, Atsuyuki; Tazoe, Hirofumi; Noda, Kaori; Hisamatsu, Shun'ichi

    2012-01-01

    A large amount of radionuclides was released from the Fukushima Dai-ichi Nuclear Power Station (FDNPS) following the damage caused by the tsunami due to the Great East Japan Earthquake on 11 March 2011. Although many radionuclides in various environmental samples around the FDNPS have been measured, (3)H in the terrestrial environment has not yet been reported. We present here the first survey results of (3)H concentrations in plant samples collected around the FDNPS in 2011 from shortly after the accident. The free-water (3)H concentrations in herbaceous plant shoots and evergreen tree leaves were considerably higher than the previous background concentration, and diminished with distance from the FDNPS. Although reconstruction of atmospheric (3)H concentrations after the accident is difficult, a rough estimate of the radiation dose due to (3)H inhalation about 20 km from the FDNPS is on the order of a few microsieverts (μSv).

  11. Indoor Rn-222 concentrations in the vicinity of a Turkish coal-fired power plant

    Energy Technology Data Exchange (ETDEWEB)

    Yaprak, G. [Ege University, Izmir (Turkey). Inst. of Nuclear Science

    1999-10-01

    Coal, like most materials found in nature, contains natural radionuclides and their products in small quantities. Therefore, depending on their concentration in the coal, a coal-fired power plant might potentially contaminate the environment. Indoor Rn-222 concentration in 100 houses located in the vicinity of Yatagan coal-fired power plant in the southwestern part of Turkey were measured using solid state nuclear track detectors. The time-integrated Rn-222 concentrations in the houses ranged from 10 to 120 Bq m{sup -3}. This corresponds to an annual effective dose equivalent ranging from 0.6 to 7/3 mSv. In 96% of the homes, an Rn-222 concentration of 100 Bq m{sup -3} (taken as the limit for future buildings, recommended by ICRP) was not exceeded.

  12. Activity concentrations and mean annual effective dose of foodstuffs on the island of Tenerife, Spain.

    Science.gov (United States)

    Hernández, F; Hernández-Armas, J; Catalán, A; Fernández-Aldecoa, J C; Landeras, M I

    2004-01-01

    A total of 26 different food types and 12 elaborated diets were analysed by low-level gamma spectrometry to measure their content of 238U(234Th), 228Ra(228Ac), 226Ra(214Pb), 210Pb, 137Cs and 40K. The concentrations of these radionuclides measured in some imported foodstuffs were compared with those measured in some locally produced ones. Moreover, the concentrations found in the analysed foodstuffs and composite diets were compared with the data available in literature from other locations, such as Egypt, Brazil, Poland and Hong Kong. 40K contributed highest to the daily dose produced by the intake of comestibles. The largest 40K concentrations were measured in the chickpeas and beans with 380 +/- 30 and 380 +/- 20 Bq kg(-1) fresh weights, respectively. The artificial radionuclide 137Cs was measured only above detection limits in the potatoes and sweet potatoes. A mean annual effective dose of 362 microSv with a standard deviation of 110 microSv was calculated from the composite diets.

  13. Variation of indoor radon concentration and ambient dose equivalent rate in different outdoor and indoor environments

    Energy Technology Data Exchange (ETDEWEB)

    Stojanovska, Zdenka; Janevik, Emilija; Taleski, Vaso [Goce Delcev University, Faculty of Medical Sciences, Stip (Macedonia, The Former Yugoslav Republic of); Boev, Blazo [Goce Delcev University, Faculty of Natural and Technical Sciences, Stip (Macedonia, The Former Yugoslav Republic of); Zunic, Zora S. [University of Belgrade, Institute of Nuclear Sciences ' ' Vinca' ' , Belgrade (Serbia); Ivanova, Kremena; Tsenova, Martina [National Center of Radiobiology and Radiation Protection, Sofia (Bulgaria); Ristova, Mimoza [University in Ss. Cyril and Methodius, Faculty of Natural Sciences and Mathematic, Institute of Physics, Skopje (Macedonia, The Former Yugoslav Republic of); Ajka, Sorsa [Croatian Geological Survey, Zagreb (Croatia); Bossew, Peter [German Federal Office for Radiation Protection, Berlin (Germany)

    2016-05-15

    Subject of this study is an investigation of the variations of indoor radon concentration and ambient dose equivalent rate in outdoor and indoor environments of 40 dwellings, 31 elementary schools and five kindergartens. The buildings are located in three municipalities of two, geologically different, areas of the Republic of Macedonia. Indoor radon concentrations were measured by nuclear track detectors, deployed in the most occupied room of the building, between June 2013 and May 2014. During the deploying campaign, indoor and outdoor ambient dose equivalent rates were measured simultaneously at the same location. It appeared that the measured values varied from 22 to 990 Bq/m{sup 3} for indoor radon concentrations, from 50 to 195 nSv/h for outdoor ambient dose equivalent rates, and from 38 to 184 nSv/h for indoor ambient dose equivalent rates. The geometric mean value of indoor to outdoor ambient dose equivalent rates was found to be 0.88, i.e. the outdoor ambient dose equivalent rates were on average higher than the indoor ambient dose equivalent rates. All measured can reasonably well be described by log-normal distributions. A detailed statistical analysis of factors which influence the measured quantities is reported. (orig.)

  14. Radon Concentrations in Drinking Water in Beijing City, China and Contribution to Radiation Dose

    Directory of Open Access Journals (Sweden)

    Yun-Yun Wu

    2014-10-01

    Full Text Available 222Rn concentrations in drinking water samples from Beijing City, China, were determined based on a simple method for the continuous monitoring of radon using a radon-in-air monitor coupled to an air-water exchanger. A total of 89 water samples were sampled and analyzed for their 222Rn content. The observed radon levels ranged from detection limit up to 49 Bq/L. The calculated arithmetic and geometric means of radon concentrations in all measured samples were equal to 5.87 and 4.63 Bq/L, respectively. The average annual effective dose from ingestion of radon in drinking water was 2.78 μSv, and that of inhalation of water-borne radon was 28.5 μSv. It is concluded that it is not the ingestion of waterborne radon, but inhalation of the radon escaping from water that is a substantial part of the radiological hazard. Radon in water is a big concern for public health, especially for consumers who directly use well water with very high radon concentration.

  15. Radon Concentrations in Drinking Water in Beijing City, China and Contribution to Radiation Dose

    Science.gov (United States)

    Wu, Yun-Yun; Ma, Yong-Zhong; Cui, Hong-Xing; Liu, Jian-Xiang; Sun, Ya-Ru; Shang, Bing; Su, Xu

    2014-01-01

    222Rn concentrations in drinking water samples from Beijing City, China, were determined based on a simple method for the continuous monitoring of radon using a radon-in-air monitor coupled to an air-water exchanger. A total of 89 water samples were sampled and analyzed for their 222Rn content. The observed radon levels ranged from detection limit up to 49 Bq/L. The calculated arithmetic and geometric means of radon concentrations in all measured samples were equal to 5.87 and 4.63 Bq/L, respectively. The average annual effective dose from ingestion of radon in drinking water was 2.78 μSv, and that of inhalation of water-borne radon was 28.5 μSv. It is concluded that it is not the ingestion of waterborne radon, but inhalation of the radon escaping from water that is a substantial part of the radiological hazard. Radon in water is a big concern for public health, especially for consumers who directly use well water with very high radon concentration. PMID:25350007

  16. Variation of indoor radon concentrations in two-storey houses in Nowshera District, Pakistan.

    Science.gov (United States)

    Khan, F; Wazir, Z; Tufail, M; Nusrat, M

    2015-01-01

    A study was performed for the measurement of indoor radon concentration in two-storey houses in district Nowshera in the Khyber Pakhtunkhwa province of Pakistan. This area was not previously surveyed for such kind of study. The aim was to find some correlation of radon levels in first and second storey houses in the area. The measurements were carried out for 1 y from 1 December 2012 to 30 November 2013 using CR-39 detector. The area was divided into four parts, namely, Jhangera, Nowshera city, Akora Khattak and Pabbi. In the first storey houses, radon concentration ranged from 29 to 103 Bq m(-3) with the mean value of 64 ± 12 Bq m(-3) and that in the second storey houses ranged from 25 to 92 Bq m(-3) with the mean value of 56 ± 11 Bq m(-3). Relatively higher values of indoor radon levels in the first stories than the second stories were observed in all four parts of the study area. The effective doses received by the residents of the area were estimated for each part. The mean annual effective doses received by the inhabitants of the area from indoor radon ranged from 0.68 to 2.88 mSv with the mean value of 1.68 ± 0.32 mSv. The doses received by the people of the area were within the ICRP-65 recommended range (3-10 mSv). © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Determination of activity concentration levels of (238)U, (232)Th, and (40)K in drinking water in a gold mine in Ghana.

    Science.gov (United States)

    Awudu, A R; Darko, E O; Schandorf, C; Hayford, E K; Abekoe, M K; Ofori-Danson, P K

    2010-08-01

    The study of the activity concentration levels of uranium, thorium and potassium in drinking water from different locations in a gold mine in the Ashanti Region of Ghana was conducted using gamma spectrometry. The mean outdoor absorbed gamma dose rates at 1 m from the water were 0.524 nGy h, 0.422 nGy h, and 0.252 nGy h for groundwater, surface water, and treated water, respectively. The results obtained for the activity concentration levels of U and Th are found to be within the maximum acceptable concentration levels of 3.0 Bq L and 0.6 Bq L, respectively, recommended by the World Health Organization. The overall mean outdoor gamma dose rate is 0.41 nGy h and the corresponding outdoor annual effective dose obtained for adult members of the public for drinking water from the mines is 3.58 muSv y. This value is found to be within the 10.0 muSv per annum (0.01 mSv per annum) for public exposure control set by the World Health Organization. Therefore, the mining activities on drinking water studied did not show any significant radiological health implications on the public.

  18. Urine concentration test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003608.htm Urine concentration test To use the sharing features on this page, please enable JavaScript. A urine concentration test measures the ability of the kidneys to ...

  19. Air Data - Concentration Map

    Science.gov (United States)

    Make a map of daily concentrations over several days. The daily air quality can be displayed in terms of the Air Quality Index or in concentration ranges for certain PM species like organic carbon, nitrates, and sulfates.

  20. National Geochemical Database: Concentrate

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Geochemistry of concentrates from the National Geochemical Database. Primarily inorganic elemental concentrations, most samples are from the continental US and...

  1. Rheology of concentrated biomass

    Science.gov (United States)

    J.R. Samaniuk; J. Wang; T.W. Root; C.T. Scott; D.J. Klingenberg

    2011-01-01

    Economic processing of lignocellulosic biomass requires handling the biomass at high solids concentration. This creates challenges because concentrated biomass behaves as a Bingham-like material with large yield stresses. Here we employ torque rheometry to measure the rheological properties of concentrated lignocellulosic biomass (corn stover). Yield stresses obtained...

  2. Image quality of ultra-low radiation exposure coronary CT angiography with an effective dose <0.1 mSv using high-pitch spiral acquisition and raw data-based iterative reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Schuhbaeck, Annika; Achenbach, Stephan; Hecker, Franziska; Rixe, Johannes [University of Giessen, Department of Cardiology, Giessen (Germany); Layritz, Christian; Eisentopf, Jasmin; Pflederer, Tobias; Gauss, Soeren; Kalender, Willi; Daniel, Werner G.; Lell, Michael; Ropers, Dieter [University of Erlangen, Departments of Cardiology and Radiology, Erlangen (Germany)

    2013-03-15

    We evaluated the potential of prospectively ECG-triggered high-pitch spiral acquisition with low tube voltage and current in combination with iterative reconstruction to achieve coronary CT angiography with sufficient image quality at an effective dose below 0.1 mSv. Contrast-enhanced coronary dual source CT angiography (2 x 128 x 0.6 mm, 80 kV, 50 mAs) in prospectively ECG-triggered high-pitch spiral acquisition mode was performed in 21 consecutive individuals (body weight <100 kg, heart rate {<=}60/min). Images were reconstructed with raw data-based filtered back projection (FBP) and iterative reconstruction (IR). Image quality was assessed on a 4-point scale (1 = no artefacts, 4 = unevaluable). Mean effective dose was 0.06 {+-} 0.01 mSv. Image noise was significantly reduced in IR (128.9 {+-} 46.6 vs. 158.2 {+-} 44.7 HU). The mean image quality score was lower for IR (1.9 {+-} 1.1 vs. 2.2 {+-} 1.0, P < 0.0001). Of 292 coronary segments, 55 in FBP and 40 in IR (P = 0.12) were graded ''unevaluable''. In patients with a body weight {<=}75 kg, both in FBP and in IR, the rates of fully evaluable segments were significantly higher in comparison to patients >75 kg. Coronary CT angiography with an estimated effective dose <0.1 mSv may provide sufficient image quality in selected patients through the combination of high-pitch spiral acquisition and raw data-based iterative reconstruction. (orig.)

  3. Influence of Genetic Background on Hematologic and Histopathologic Alterations during Acute Granulocytic Anaplasmosis in 129/SvEv and C57BL/6J Mice Lacking Type I and Type II Interferon Signaling.

    Science.gov (United States)

    Johns, Jennifer L; Discipulo, Marielle L; Koehne, Amanda L; Moorhead, Kaitlin A; Nagamine, Claude M

    2017-03-01

    The role of host type I IFN signaling and its interaction with other immune pathways during bacterial infections is incompletely understood. Type II IFN signaling plays a key role during numerous bacterial infections including granulocytic anaplasmosis (GA) caused by Anaplasma phagocytophilum infection. The function of combined type I and type II IFN signaling and their potential synergism during GA and similar tick-borne diseases is a topic of current research investigation. The goal of this study was to evaluate 2 mouse models of absent type I/type II IFN signaling in experimental A. phagocytophilum infection to determine the effects of background strain. Mice lacking both type I and type II IFN receptor signaling (IFNAR-/-/IFNGR-/-) on either the 129/SvEv or C57BL/6J genetic background were evaluated at days 0, 6, 8, and 12 of infection. Pathogen burden in multiple organs was largely similar between strains of infected mice, with few significant differences. Background strain influenced the immune response to infection. Mice of the 129/SvEv strain developed more severe hematologic abnormalities, particularly more severe leukocytosis with marked neutrophilia and lymphocytosis, throughout acute infection. Histopathologic changes occurred in infected mice of both strains and varied in severity by organ. 129/SvEv mice developed more severe pathologic changes in spleen and bone marrow, whereas C57BL/6J mice developed more severe renal pathology. This work highlights the importance of mouse background strain in dictating pathophysiologic response to infection and informs future work regarding the loss of type I and type II IFN signaling on the immune response during GA.

  4. The MRC-5 human embryonal lung fibroblast two-dimensional gel cellular protein database: quantitative identification of polypeptides whose relative abundance differs between quiescent, proliferating and SV40 transformed cells

    DEFF Research Database (Denmark)

    Celis, J E; Dejgaard, K; Madsen, Peder

    1990-01-01

    (1323 with isoelectric focusing and 572 with nonequilibrium pH gradient electrophoresis) are recorded in this database, containing quantitative and qualitative data on the relative abundance of cellular proteins synthesized by quiescent, proliferating and SV40 transformed MRC-5 fibroblasts. Of the 592......A new version of the MRC-5 two-dimensional gel cellular protein database (Celis et al., Electrophoresis 1989, 10, 76-115) is presented. Gels were scanned with a Molecular Dynamics laser scanner and processed by the PDQUEST II software. A total of 1895 [35S]methionine-labeled cellular polypeptides...

  5. Determination of tritium concentrations in humans before the development of a nuclear power plant in Turkey.

    Science.gov (United States)

    Dizman, Serdar; Yilmaz, Adnan; Keser, Recep

    2015-01-01

    The most widely used method to determine the level of tritium in humans is testing urine. Tritium concentrations in urine samples of 100 persons aged 18-66 years selected randomly from a pilot region in Turkey were analysed. The average activity concentration of urine samples was 4.66 ± 1.94 Bq L(-1) and the maximum activity concentration was 27.91 Bq L(-1). The minimum detectable activity was 2.38 Bq L(-1). The annual effective dose from tritium was also evaluated on the basis of the measurement results and reference values recommended by the International Commission on Radiological Protection. The effective doses for males and females were 4.56 and 3.54 nSv, respectively. These results were lower than the permissible annual effective dose for members of the public.

  6. Determination of 210Po concentration in commercially available infant formulae and assessment of daily ingestion dose

    Directory of Open Access Journals (Sweden)

    Ravi K. Prabhath

    2015-07-01

    Full Text Available A study has been conducted to estimate the concentration of natural radioactive polonium in commercially available packaged infant food formulae available in Mumbai, India and the corresponding daily dose normalized based on its shelf life. Eleven most popular international brands of infant formulae were sourced from market and three aliquots from each sample were analysed for concordant results. Autodeposition method onto a silver planchet from hot dilute acid solution followed by alpha spectrometry was performed for estimation of polonium. Radiochemical recovery was ascertained by the addition of 209Po tracer. Radiochemical recovery of 209Po tracer was ranged from 14.7 to 98.1 %. The 210Po concentration in the samples was in the range of 0.08–0.23 Bq kg−1 on measured date and the corresponding daily dose, calculated on normalized date which is at mid-point of the shelf life of the sample, was ranged from 0.04 to 0.89 μSv d−1 as per the recommended daily consumption. The annual committed effective dose estimated based on the average of daily dose was found to be 150 μSv.

  7. 10-12 gadus vecu pusaudžu emociju un jūtu attīstīšana Svētdienas skolas nodarbībās

    OpenAIRE

    Rubene, Inga

    2007-01-01

    Bakalaura darbs „ 7-10 gadus vecu bērnu jūtu un emociju attīstīšana Svētdienas skolās”. Šīs tēmas nozīmi raksturo apstāklis, ka arvien biežāk nākas sastapties ar bērniem un pusaudžiem, kuru uztverē un domāšanā redzams emocionālais un jūtu deficīts. Bakalaura darba mērķis ir izveidot Svētdienas skolas nodarbību metodiskos ieteikumus bērnu emociju un jūtu attīstīšanai jaunākajā skolas vecumā. Pētījumā īstenoti šādi pamatuzdevumi - iepazīties ar zinātnisko literatūru par jaunāko skolas v...

  8. Concentrators using fluorescent substances

    Energy Technology Data Exchange (ETDEWEB)

    Hayashibara, M.; Tsukamoto, M. (Hitachi Seisakusho K.K., Tokyo (Japan))

    1990-01-01

    In luminescent concentrators - plates of polymethylmethacrylate (PMMA) or other transparent material with a fluorescent compound dispersed within them - incident light is trapped and concentrated by internal reflection, and shifted to a longer wavelength, as it interacts with fluorescent particles. Experience with the use of luminescent concentrators for electricity generation in conjunction with solar cells, in solar heaters, in amplifiers for light intensity, in long-wave converters and in display panels is discussed. Solar energy conversion efficiencies of 4-5% have been obtained in generating systems combining concentrators containing Fluorol 555 or Rhodamin 6G with GaAs solar cells. (author).

  9. Study of the specific concentrations of {sup 40}K, {sup 224}Ra, {sup 226}Ra and {sup 228}Ra in some seasonings marketed in Rio de Janeiro City

    Energy Technology Data Exchange (ETDEWEB)

    Garcêz, Ricardo W.D.; Lopes, José M.; Silva, Leandro B.; Silva, Ademir X. da [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Lima, Marco A.F., E-mail: rgarcez@nuclear.ufrj.br [Universidade Federal Fluminense (UFF), Niterói, RJ (Brazil). Instituto de Biologia

    2017-07-01

    The seasoning are vegetables substances used in foods to enhance their flavor, aroma and color. This work presents an investigation of the activity concentration of Naturally Occurring Radioactive Materials (NORMs) in 28 samples of seasoning utilized by brazilian population. The seasoning samples were measured using gamma spectroscopy technique with a high-purity germanium (HPGe) detector, a non-destructive nuclear method and with the LabSOCS software for the calculation of the efficiency curve. The analysis shows that the activity concentration of {sup 40}K was measured in all samples and ranges from 21.0 Bq/kg to 1288 Bq/kg. The highest concentration activity of {sup 40}K was measured to 'cheiro verde', a local seasoning made of chives (Allium Schoenoprasum) and parsley (Petroselinum Crispum), while annatto, made with the fruit of Bixa Orelhana, had the lowest activity concentration. Brazil nut (Bertholletia Excelsa) presented the highest concentrations for {sup 226}Ra and {sup 228}Ra with 24 Bq/kg and 25.7 Bq/kg, respectively and black pepper (Piper Nigrum) presented the highest concentration for {sup 224}Ra with 33.9 Bq/kg. The highest effective dose for members of the public due to ingestion was 23.5 μSv/y due to Brazil nut and the lowest effective dose was found for annatto: 0.13 μSv/y. The syrian seasoning sample present specific concentration of 6.1±1.1 Bq/kg for {sup 137}Cs and 0.08 μSv/y of effective dose. The values found in this work do not represent a risk to human health. (author)

  10. Světové přírodní katastrofy - výuková příručka pro 2 st. ZŠ

    OpenAIRE

    VYSKOČILOVÁ, Monika

    2010-01-01

    This diploma thesis is entitled the Global Natural Disasters {--} Teacher{\\crq}s Book for the 2 nd stage of PS. The principal part of thesis concentrates on the proposal of own package of didactic material {--} teaching text, workbook, and methodical teacher{\\crq}s book aimed at the study of natural disasters and environmental hazards worldwide. This didactic material should serve as an additional teaching aid within the framework of the teaching of geography at the 2 nd stage of primary scho...

  11. Postavení Španělska na světovém trhu olivového oleje

    OpenAIRE

    Skolková, Klára

    2015-01-01

    This bachelor thesis deals with the position of Spain on the world olive oil market. The first chapter of the thesis concentrates on the characteristics of olive oil, its history, classification and labeling, the impact of olive oil on health, the areas of olive oil production and it also presents the International Olive Council. The second part of the thesis focuses on olive oil production and consumption of selected autonomous communities of Spain. It also includes an analysis of the territ...

  12. Strategies to Support Concentration

    Science.gov (United States)

    Haines, Annette

    2017-01-01

    Annette Haines provides a comprehensive overview of concentration across the planes. She first lays the foundation for thinking about student engagement: It must be understood that concentration is found through the interest of the child, which is guided by the sensitive periods. When we understand the child's development in this way, we can offer…

  13. The effect of two-zone concentric bifocal spectacle lenses on refractive error development and eye growth in young chicks.

    Science.gov (United States)

    Liu, Yue; Wildsoet, Christine

    2011-02-01

    To characterize the effects on refractive error development and eye growth in young chicks of two-zone concentric lens designs, which differentially affect the defocus experiences of central and peripheral retinal regions. Monocular defocusing lenses were worn for 5 days from 17 days of age. Four two-zone concentric lens designs (overall optical zone diameter, 10 mm) combining plano with either -5- or +5-D power were used. Lens designs were as follows: (1) +5 D center (+5C), (2) +5 D periphery (+5P), (3) -5 D center (-5C), and (4) -5 D peripheral (-5P), with plano in periphery for all C-designs and in the center for P-designs. Five central zone diameters (CZDs) were tested, ranging from 2.5 to 6.5 mm in 1-mm increments. Plano, +5- and -5-D single-vision (SV) lenses were used as the control. A minimum of six birds were included in each lens group. For the two-zone lenses, the P designs (i.e., peripheral defocus) had greater effects than the C designs (i.e., central defocus) on both on-axis eye growth and refractions. All but the 6.5-mm CZD +5P lens induced larger changes than the +5SV lens. The +5C lenses with CZD less than 5.5 mm had little effect. The two-zone -5-D lenses had less effect than the -5SV lens, and only the 6.5-mm CZD lens of the -5C series had a significant effect. The results demonstrate that peripheral defocus can influence both peripheral and central refractive development. The inhibitory effect on axial eye growth of the +5P lenses opens the possibility that appropriately designed concentric lenses may control the progression of human myopia.

  14. Concentrating photovoltaic solar panel

    Science.gov (United States)

    Cashion, Steven A; Bowser, Michael R; Farrelly, Mark B; Hines, Braden E; Holmes, Howard C; Johnson, Jr., Richard L; Russell, Richard J; Turk, Michael F

    2014-04-15

    The present invention relates to photovoltaic power systems, photovoltaic concentrator modules, and related methods. In particular, the present invention features concentrator modules having interior points of attachment for an articulating mechanism and/or an articulating mechanism that has a unique arrangement of chassis members so as to isolate bending, etc. from being transferred among the chassis members. The present invention also features adjustable solar panel mounting features and/or mounting features with two or more degrees of freedom. The present invention also features a mechanical fastener for secondary optics in a concentrator module.

  15. Concentrated Differential Privacy

    OpenAIRE

    Dwork, Cynthia; Rothblum, Guy N.

    2016-01-01

    We introduce Concentrated Differential Privacy, a relaxation of Differential Privacy enjoying better accuracy than both pure differential privacy and its popular "(epsilon,delta)" relaxation without compromising on cumulative privacy loss over multiple computations.

  16. Concentrations of Indicator Organisms

    Data.gov (United States)

    U.S. Environmental Protection Agency — It is a compilation of organism concentrations of 16 sampling events conducted between July 2015 and February 2016. It also includes statistical analysis such as...

  17. Censored correlated cytokine concentrations

    DEFF Research Database (Denmark)

    Andersen, Andreas; Benn, Christine Stabell; Jørgensen, Mathias J

    2013-01-01

    Interest in cytokines as markers for the function of the immune system is increasing. Methods quantifying cytokine concentrations are often subject to detection limits, which lead to non-detectable observations and censored distributions. When distributions are skewed, geometric mean ratios (GMRs......) can be used to describe the relative concentration between two cytokines, and the GMR ratio (GMRR) can be used to compare two groups. The problem is how to estimate GMRRs from censored distributions.We evaluated methods, including simple deletion and substitution, in simulated and real data. One...... method applies Tobit directly to the censored difference between the two cytokine log-concentrations (Diff). However, censoring is correlated to the outcome and is therefore not independent. The correlation increases as the correlation between the two log-concentrations decreases. We propose a Tobit...

  18. CMAQ predicted concentration files

    Data.gov (United States)

    U.S. Environmental Protection Agency — model predicted concentrations. This dataset is associated with the following publication: Muñiz-Unamunzaga, M., R. Borge, G. Sarwar, B. Gantt, D. de la Paz, C....

  19. Metformin action: concentrations matter.

    Science.gov (United States)

    He, Ling; Wondisford, Fredric E

    2015-02-03

    Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. METHOD OF ISOTOPE CONCENTRATION

    Science.gov (United States)

    Spevack, J.S.

    1957-04-01

    An isotope concentration process is described which consists of exchanging, at two or more different temperature stages, two isotopes of an element between substances that are physically separate from each other and each of which is capable of containing either of the isotopes, and withdrawing from a point between at least two of the temperatare stages one of the substances containing an increased concentration of the desired isotope.

  1. Computer designed solar concentrator

    Energy Technology Data Exchange (ETDEWEB)

    Aliman, O.; Daut, I.; Lim, C.S.; Isa, M.; Adzman, M.R. [Kolej Univ. Kejuruteraan Utara Malaysia, Perlis (Malaysia). School of Electrical System Engineering

    2007-07-01

    A new method of sun tracking has been proposed and demonstrated at the University of Technology Malaysia. The heliostat not only tracks the sun but also concentrates all of the sun images from its mirrors into a single image at a stationary target. Because of this, the target image can be made small enough so that a relatively small concentrator or receiver is required to collect the solar energy. A single cylinder, beta type Stirling engine has been built to work with this heliostat as a whole system. This paper discussed the computer designed optical concentrator, that was providing efficient solar energy transfer to a Stirling engine. The paper discussed the development of a prototype optical concentrator. The computer-simulated characteristics of the receiver as well as the experimental data of its performance were presented. It was concluded that coupling with a non-imaging focusing heliostat, the prototype optical concentrator was successful in running a small scale Stirling engine. The contribution of the optical concentrator to heliostat application was encouraging. 3 refs., 1 tab., 10 figs.

  2. Low-Dose (2-mSv) CT in Adolescents and Young Adults With Suspected Appendicitis: Advantages of Additional Review of Thin Sections Using Multiplanar Sliding-Slab Averaging Technique.

    Science.gov (United States)

    Lee, Yoon Jin; Kim, Bohyoung; Ko, Yousun; Cho, Kyung Eun; Hong, Seong Sook; Kim, Dong Hwan; Song, Hyunjoo; Lee, Kyoung Ho

    2015-11-01

    The purpose of this study is to assess the advantages of additional multiplanar sliding-slab averaging review of 2-mm-thick (thin) sections over stack review of 5-mm-thick (thick) sections in difficult cases of 2-mSv CT in adolescents and young adults with suspected appendicitis. We included 149 patients (mean age, 28.0 years; 61 male patients and 88 female patients) for whom the initial CT reports were inconclusive for the diagnosis of appendicitis. Five independent radiologists retrospectively reviewed the thick sections in the stack mode and then the thin sections using sliding-slab averaging. In each review, they rated the likelihood of appendicitis and the appendix visualization using 5- and 3-point Likert scales, respectively. Diagnostic performance and confidence were compared between the two reviews using ROC analysis, McNemar tests, and Wilcoxon signed-rank tests. The pooled AUCs were 0.90 and 0.93 for the stack and sliding-slab averaging reviews, respectively (90% CI for the difference, 0.002-0.06; p = 0.087). For the individual readers, the sliding-slab averaging review tended to increase the AUC (range, 0.86-0.93 for stack vs 0.87-0.97 for sliding-slab averaging review), improve the confidence in diagnosing (mean score, 3.6-4.7 vs 3.9-4.7) or ruling out (1.6-2.1 vs 1.5-1.9) appendicitis, reduce indeterminate interpretations (0-15% vs 0-11%), and enhance the normal appendix visualization (1.1-1.7 vs 1.1-1.9), although the differences were not always statistically significant. Sliding-slab averaging review of thin sections is helpful when the diagnosis of appendicitis is difficult at 2-mSv CT in adolescents and young adults.

  3. Sub-subleading soft gravitons and large diffeomorphisms

    CERN Document Server

    Campiglia, Miguel

    2016-01-01

    We present strong evidence that the sub-subleading soft theorem in semi-classical (tree level) gravity discovered by Cachazo and Strominger is equivalent to the conservation of asymptotic charges associated to a new class of vector fields not contained within the previous extensions of BMS algebra. Our analysis crucially relies on analyzing the hitherto established equivalences between soft theorems and Ward identities from a new perspective. In this process we naturally (re)discover a class of `magnetic' charges at null infinity that are associated to the dual of the Weyl tensor.

  4. Large deformation diffeomorphic registration of diffusion-weighted imaging data

    OpenAIRE

    Zhang, Pei; Niethammer, Marc; Shen, Dinggang; Yap, Pew-Thian

    2014-01-01

    Registration plays an important role in group analysis of diffusion-weighted imaging (DWI) data. It can be used to build a reference anatomy for investigating structural variation or tracking changes in white matter. Unlike traditional scalar image registration where spatial alignment is the only focus, registration of DWI data requires both spatial alignment of structures and reorientation of local signal profiles. As such, DWI registration is much more complex and challenging than scalar im...

  5. Higher-order Spatial Accuracy in Diffeomorphic Image Registration

    DEFF Research Database (Denmark)

    Jacobs, Henry O.; Sommer, Stefan

    We discretize a cost functional for image registration problems by deriving Taylor expansions for the matching term. Minima of the discretized cost functionals can be computed with no spatial discretization error, and the optimal solutions are equivalent to minimal energy curves in the space of kk...

  6. Constrained H1-regularization schemes for diffeomorphic image registration

    Science.gov (United States)

    Mang, Andreas; Biros, George

    2017-01-01

    We propose regularization schemes for deformable registration and efficient algorithms for their numerical approximation. We treat image registration as a variational optimal control problem. The deformation map is parametrized by its velocity. Tikhonov regularization ensures well-posedness. Our scheme augments standard smoothness regularization operators based on H1- and H2-seminorms with a constraint on the divergence of the velocity field, which resembles variational formulations for Stokes incompressible flows. In our formulation, we invert for a stationary velocity field and a mass source map. This allows us to explicitly control the compressibility of the deformation map and by that the determinant of the deformation gradient. We also introduce a new regularization scheme that allows us to control shear. We use a globalized, preconditioned, matrix-free, reduced space (Gauss–)Newton–Krylov scheme for numerical optimization. We exploit variable elimination techniques to reduce the number of unknowns of our system; we only iterate on the reduced space of the velocity field. Our current implementation is limited to the two-dimensional case. The numerical experiments demonstrate that we can control the determinant of the deformation gradient without compromising registration quality. This additional control allows us to avoid oversmoothing of the deformation map. We also demonstrate that we can promote or penalize shear whilst controlling the determinant of the deformation gradient. PMID:29075361

  7. Numerical simulation of nonlinear continuity equations by evolving diffeomorphisms

    KAUST Repository

    Carrillo, José A.

    2016-09-22

    In this paper we present a numerical scheme for nonlinear continuity equations, which is based on the gradient flow formulation of an energy functional with respect to the quadratic transportation distance. It can be applied to a large class of nonlinear continuity equations, whose dynamics are driven by internal energies, given external potentials and/or interaction energies. The solver is based on its variational formulation as a gradient flow with respect to the Wasserstein distance. Positivity of solutions as well as energy decrease of the semi-discrete scheme are guaranteed by its construction. We illustrate this property with various examples in spatial dimension one and two.

  8. Emergent diffeomorphism invariance in a discrete loop quantum gravity model

    OpenAIRE

    Gambini, Rodolfo; Pullin, Jorge

    2008-01-01

    Several approaches to the dynamics of loop quantum gravity involve discretizing the equations of motion. The resulting discrete theories are known to be problematic since the first class algebra of constraints of the continuum theory becomes second class upon discretization. If one treats the second class constraints properly, the resulting theories have very different dynamics and number of degrees of freedom than those of the continuum theory. It is therefore questionable how these theories...

  9. Diffeomorphism Group Representations in Relativistic Quantum Field Theory

    Energy Technology Data Exchange (ETDEWEB)

    Goldin, Gerald A. [Rutgers Univ., Piscataway, NJ (United States); Sharp, David H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-12-20

    We explore the role played by the di eomorphism group and its unitary representations in relativistic quantum eld theory. From the quantum kinematics of particles described by representations of the di eomorphism group of a space-like surface in an inertial reference frame, we reconstruct the local relativistic neutral scalar eld in the Fock representation. An explicit expression for the free Hamiltonian is obtained in terms of the Lie algebra generators (mass and momentum densities). We suggest that this approach can be generalized to elds whose quanta are spatially extended objects.

  10. Radiological assessment of water treatment processes in a water treatment plant in Saudi Arabia: Water and sludge radium content, radon air concentrations and dose rates

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jaseem, Q.Kh., E-mail: qjassem@kacst.edu.sa [Nuclear Science Research Institute (NSRI), King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442 (Saudi Arabia); Almasoud, Fahad I. [Nuclear Science Research Institute (NSRI), King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442 (Saudi Arabia); Ababneh, Anas M. [Physics Dept., Faculty of Science, Islamic University in Madinah, Al-Madinah, P.O. Box 170 (Saudi Arabia); Al-Hobaib, A.S. [Nuclear Science Research Institute (NSRI), King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442 (Saudi Arabia)

    2016-09-01

    There is an increase demand for clean water sources in Saudi Arabia and, yet, renewable water resources are very limited. This has forced the authorities to explore deep groundwater which is known to contain large concentrations of radionuclides, mainly radium isotopes. Lately, there has been an increase in the number of water treatment plants (WTPs) around the country. In this study, a radiological assessment of a WTP in Saudi Arabia was performed. Raw water was found to have total radium activity of 0.23 Bq/L, which exceeds the international limit of 0.185 Bq/L (5 pCi/L). The WTP investigated uses three stages of treatment: flocculation/sedimentation, sand filtration and reverse osmosis. The radium removal efficiency was evaluated for each stage and the respective values were 33%, 22% and 98%. Moreover, the activity of radium in the solid waste generated from the WTP in the sedimentation and sand filtrations stages were measured and found to be 4490 and 6750 Bq/kg, respectively, which exceed the national limit of 1000 Bq/kg for radioactive waste. A radiological assessment of the air inside the WTP was also performed by measuring the radon concentrations and dose rates and were found in the ranges of 2–18 Bq/m{sup 3} and 70–1000 nSv/h, respectively. The annual effective dose was calculated and the average values was found to be 0.3 mSv which is below the 1 mSv limit. - Highlights: • Radiological assessment of groundwater treatment plant was performed. • Radium Removal efficiency was calculated for different stages during water treatment. • Radium concentrations in sludge were measured and found to exceed the national limit for radioactive waste. • Air radon concentrations and dose rates were monitored in the water treatment plant. • The Reverse Osmosis (RO) unit was found to record the highest air radon concentrations and dose rates.

  11. Thermal cloak-concentrator

    Science.gov (United States)

    Shen, Xiangying; Li, Ying; Jiang, Chaoran; Ni, Yushan; Huang, Jiping

    2016-07-01

    For macroscopically manipulating heat flow at will, thermal metamaterials have opened a practical way, which possesses a single function, such as either cloaking or concentrating the flow of heat even though environmental temperature varies. By developing a theory of transformation heat transfer for multiple functions, here we introduce the concept of intelligent thermal metamaterials with a dual function, which is in contrast to the existing thermal metamaterials with single functions. By assembling homogeneous isotropic materials and shape-memory alloys, we experimentally fabricate a kind of intelligent thermal metamaterials, which can automatically change from a cloak (or concentrator) to a concentrator (or cloak) when the environmental temperature changes. This work paves an efficient way for a controllable gradient of heat, and also provides guidance both for arbitrarily manipulating the flow of heat and for efficiently designing similar intelligent metamaterials in other fields.

  12. Pollutant concentrations in placenta

    DEFF Research Database (Denmark)

    Leino, O.; Kiviranta, H.; Karjalainen, A. K.

    2013-01-01

    congeners of persistent organic pollutants, seven organotin compounds, five heavy metals, and methylmercury in 130 randomly selected placentas. Additionally, we examined similarities between pollutant concentrations by analyzing correlations between their placental concentrations. Our results yield new...... information for conducting contaminant risk assessments for the prenatal period. Out of the 117 individual persistent organic pollutants or metals assayed, 46 could be detected in more than half of the placentas. Moreover, dichlorodiphenyldichloroethylene (p,p'-DDE) was found in all placentas. The data......Unborn children are exposed to environmental pollutants via the placenta, and there is a causal relationship between maternal intake of pollutants and fetal exposure. Placental examination is an effective way for acquiring data for estimating fetal exposure. We analyzed the concentrations of 104...

  13. Vacancy Concentration in Ice

    DEFF Research Database (Denmark)

    Mogensen, O. E.; Eldrup, Morten Mostgaard

    1977-01-01

    Based on the diffusion constant for self-diffusion in ice, which is believed to take place by a vacancy mechanism, we estimate the relative vacancy concentration near the melting point to be at least ∼ 10−6, i.e. much higher than previous estimates of about 10−10.......Based on the diffusion constant for self-diffusion in ice, which is believed to take place by a vacancy mechanism, we estimate the relative vacancy concentration near the melting point to be at least ∼ 10−6, i.e. much higher than previous estimates of about 10−10....

  14. Concentrated loads on concrete

    DEFF Research Database (Denmark)

    Lorenzen, Karen Grøndahl; Nielsen, Mogens Peter

    1997-01-01

    This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas are devel......This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas...

  15. Hvorfor er sproget så svært at forstå, når det er så let at forstå?

    Directory of Open Access Journals (Sweden)

    Torben Thrane

    2004-05-01

    Full Text Available In an attempt to unravel the intricate relationships between syntax and meaning, this paper clears a space between entrenched 'formalist' and 'functionalist' positions from which to defend a view of language as a 2nd order representational system. Building on information-theoretic foundations, it introduces a new first clause on top of the two clauses of Dretske’s (1995: xiii Representational Thesis, thus - All linguistic facts are mental facts (new - All mental facts are representational facts - All representational facts are facts about informational functions Concentrating on language interpretation, it argues that the proper place to look for the functionality of language is as a property of the Language Faculty as standardly conceived. It distinguishes 1°-representations (of situations from 2°-representations (of linguistic structure, claiming that the input to the cognitive interface in language interpretation is a 1°-representation converted from a sequence of 2°-representations at an interface created by a default, abstract representation of the utterance situation. It argues for a purely representational, as opposed to derivational, approach. The syntactic area discussed is that of argument structure and selection, with special reference to the status of hidden arguments and their place in syntactic representations. It is argued that argument selection is independent of, and prior to, assignment of category, case and thematic roles to constituents, and is purely a matter of the selectional properties of predicates with respect to a parameter of optionality. Four constituent types are recognized, two argumental (Complements and Arguments, two non-argumental (Satellites and Parasites; two obligatory (Complements and Parasites,two optional (Arguments and Satellites.

  16. Hvorfor er sproget så svært at forstå, når det er så let at forstå?

    Directory of Open Access Journals (Sweden)

    Torben Thrane

    2004-05-01

    Full Text Available In an attempt to unravel the intricate relationships between syntax and meaning, this paper clears a space between entrenched 'formalist' and 'functionalist' positions from which to defend a view of language as a 2nd order representational system. Building on information-theoretic foundations, it introduces a new first clause on top of the two clauses of Dretske’s (1995: xiii Representational Thesis, thus - All linguistic facts are mental facts (new - All mental facts are representational facts - All representational facts are facts about informational functions Concentrating on language interpretation, it argues that the proper place to look for the functionality of language is as a property of the Language Faculty as standardly conceived. It distinguishes 1°-representations (of situations from 2°-representations (of linguistic structure, claiming that the input to the cognitive interface in language interpretation is a 1°-representation converted from a sequence of 2°-representations at an interface created by a default, abstract representation of the utterance situation. It argues for a purely representational, as opposed to derivational, approach. The syntactic area discussed is that of argument structure and selection, with special reference to the status of hidden arguments and their place in syntactic representations. It is argued that argument selection is independent of, and prior to, assignment of category, case and thematic roles to constituents, and is purely a matter of the selectional properties of predicates with respect to a parameter of optionality. Four constituent types are recognized, two argumental (Complements and Arguments, two non-argumental (Satellites and Parasites; two obligatory (Complements and Parasites,two optional (Arguments and Satellites.

  17. Determination of Radionuclides Concentration and Average Annual Committed Effective Dose Due to Ingestion for Some Medicinal and Edible Plants from Shazand (Markazi Province, Iran

    Directory of Open Access Journals (Sweden)

    Reza Pourimani

    2016-06-01

    Full Text Available Introduction Natural and artificial radionuclides are the main sources of human radiation exposure, which enter the food chain from the environment. Radionuclides can affect human health by transferring from soil to plants and entering the human body. In this research study, we aimed to determine the activity concentrations of radionuclides and calculate the average annual committed effective dose (AACED due to the ingestion of some medicinal and edible plants from Shazand, Markazi Province, Iran. Materials and Methods The specific activities of 226Ra, 232Th, 40K, and 137Cs in eight medicinal and edible plant species and their surrounding soils were determined, using gamma-ray spectrometry and a high-purity germanium (HPGe detector. The samples were collected from Shazand, situated in Markazi Province, Iran. Results The maximum soil-to-plant transfer factor (TFfor 226Ra, 232Th, 40K, and 137Cswas estimated at 0.13, 0.13, 3.17, and 0.09, respectively. Based on the findings, the AACED for 1kg of edible plants varied from 0.63±0.16 to 13.71±0.14μSv/y. The annual gonadal dose Equivalent (AGDE varied from 556 to 717 µSv/y for the soil samples (mean: 642µSv/y. The threshold consumption rate for edible plants ranged between21.86and 82.63 kg/y. Conclusion In this study, AACED due to the ingestion of radionuclides was lower than the global average (0.3 mSv/y. Therefore, the present results indicated no radiation health risks, associated with the use of these medicinal plants for disease treatment. However, it should be noted that all soil samples and some plants were polluted by radiocesium.

  18. Concentrating Tripartite Quantum Information.

    Science.gov (United States)

    Streltsov, Alexander; Lee, Soojoon; Adesso, Gerardo

    2015-07-17

    We introduce the concentrated information of tripartite quantum states. For three parties Alice, Bob, and Charlie, it is defined as the maximal mutual information achievable between Alice and Charlie via local operations and classical communication performed by Charlie and Bob. We derive upper and lower bounds to the concentrated information, and obtain a closed expression for it on several classes of states including arbitrary pure tripartite states in the asymptotic setting. We show that distillable entanglement, entanglement of assistance, and quantum discord can all be expressed in terms of the concentrated information, thus revealing its role as a unifying informational primitive. We finally investigate quantum state merging of mixed states with and without additional entanglement. The gap between classical and quantum concentrated information is proven to be an operational figure of merit for mixed state merging in the absence of additional entanglement. Contrary to the pure state merging, our analysis shows that classical communication in both directions can provide an advantage for merging of mixed states.

  19. Solar concentrator/absorber

    Science.gov (United States)

    Von Tiesenhausen, G. F.

    1976-01-01

    Collector/energy converter, consisting of dual-slope optical concentrator and counterflow thermal energy absorber, is attached to multiaxis support structure. Efficient over wide range of illumination levels, device may be used to generate high temperature steam, serve as solar powered dryer, or power absorption cycle cooler.

  20. Evaluation of influence of fertilizers in radium concentration from tomato culture; Avaliacao da influencia dos fertilizantes nos teores de radio encontrados na cultura do tomate

    Energy Technology Data Exchange (ETDEWEB)

    Lauria, Dejanira C. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil). Dept. de Protecao Radiologica Ambiental; Ribeiro, Fernando C.A.; Alleluia, Irene B. [Instituto Nacional de Tecnologia (INT), Rio de Janeiro, RJ (Brazil). Div. de Meio Ambiente; Perez, Daniel V. [Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA), Rio de Janeiro, RJ (Brazil). Lab. de Analises de Solos e Plantas

    2001-07-01

    The fertilizer contribution to radio uptake by tomato plants was assessed. Tomato and soil samples from four different plantations were analyzed: two using organic fertilizer and two using phosphate fertilizer. The Ra concentrations in eight of the most used tomato fertilizers were determined. The concentration values ranged from 14 to 221 Bq/kg of Ra-226 and from 25 to 176 Bq/kg of Ra-228. Owing to the low Ra concentration and to the used fertilizer quantities, the fertilizers would not increase significantly the Ra soil concentration. However, the highest soil to plant concentration ratios were found in the plantations using phosphate fertilizers. This outcome pointed out the higher Ra availability in the phosphate fertilizer plantations than in the organic fertilizer plantations, showing a possible positive influence of phosphate fertilizers for the tomato Ra uptake. Due to the phosphate fertilizer used, the dose could increase from 0,05 Sv/year to 0,24 Sv/year. However this increase is not significant face the ingestion average worldwide effective dose. (author)

  1. Scattering Solar Thermal Concentrators

    Energy Technology Data Exchange (ETDEWEB)

    Giebink, Noel C. [Pennsylvania State Univ., State College, PA (United States)

    2015-01-31

    This program set out to explore a scattering-based approach to concentrate sunlight with the aim of improving collector field reliability and of eliminating wind loading and gross mechanical movement through the use of a stationary collection optic. The approach is based on scattering sunlight from the focal point of a fixed collection optic into the confined modes of a sliding planar waveguide, where it is transported to stationary tubular heat transfer elements located at the edges. Optical design for the first stage of solar concentration, which entails focusing sunlight within a plane over a wide range of incidence angles (>120 degree full field of view) at fixed tilt, led to the development of a new, folded-path collection optic that dramatically out-performs the current state-of-the-art in scattering concentration. Rigorous optical simulation and experimental testing of this collection optic have validated its performance. In the course of this work, we also identified an opportunity for concentrating photovoltaics involving the use of high efficiency microcells made in collaboration with partners at the University of Illinois. This opportunity exploited the same collection optic design as used for the scattering solar thermal concentrator and was therefore pursued in parallel. This system was experimentally demonstrated to achieve >200x optical concentration with >70% optical efficiency over a full day by tracking with <1 cm of lateral movement at fixed latitude tilt. The entire scattering concentrator waveguide optical system has been simulated, tested, and assembled at small scale to verify ray tracing models. These models were subsequently used to predict the full system optical performance at larger, deployment scale ranging up to >1 meter aperture width. Simulations at an aperture widths less than approximately 0.5 m with geometric gains ~100x predict an overall optical efficiency in the range 60-70% for angles up to 50 degrees from normal. However, the

  2. Comparative Study of Radon Concentration with Two Techniques and Elemental Analysis in Drinking Water Samples of the Jammu District, Jammu and Kashmir, India.

    Science.gov (United States)

    Kumar, Ajay; Kaur, Manpreet; Mehra, Rohit; Sharma, Dinesh Kumar; Mishra, Rosaline

    2017-10-01

    The level of radon concentration has been assessed using the Advanced SMART RnDuo technique in 30 drinking water samples from Jammu district, Jammu and Kashmir, India. The water samples were collected from wells, hand pumps, submersible pumps, and stored waters. The randomly obtained 14 values of radon concentration in water sources using the SMART RnDuo technique have been compared and cross checked by a RAD7 device. A good positive correlation (R = 0.88) has been observed between the two techniques. The overall value of radon concentration in various water sources has ranged from 2.45 to 18.43 Bq L, with a mean value of 8.24 ± 4.04 Bq L, and it agreed well with the recommended limit suggested by the European Commission and UNSCEAR. However, the higher activity of mean radon concentration was found in groundwater drawn from well, hand and submersible pumps as compared to stored water. The total annual effective dose due to radon inhalation and ingestion ranged from 6.69 to 50.31 μSv y with a mean value of 22.48 ± 11.03 μSv y. The total annual effective dose was found to lie within the safe limit (100 μSv y) suggested by WHO. Heavy metal analysis was also carried out in various water sources by using an atomic absorption spectrophotometer (AAS), and the highest value of heavy metals was found mostly in groundwater samples. The obtained results were compared with Indian and International organizations like WHO and the EU Council. Among all the samples, the elemental analysis is not on the exceeding side of the permissible limit.

  3. Electrolyte Concentrates Treat Dehydration

    Science.gov (United States)

    2009-01-01

    Wellness Brands Inc. of Boulder, Colorado, exclusively licensed a unique electrolyte concentrate formula developed by Ames Research Center to treat and prevent dehydration in astronauts returning to Earth. Marketed as The Right Stuff, the company's NASA-derived formula is an ideal measure for athletes looking to combat dehydration and boost performance. Wellness Brands also plans to expand with products that make use of the formula's effective hydration properties to help treat conditions including heat stroke, altitude sickness, jet lag, and disease.

  4. Study of the specific concentrations of {sup 40}K and other radionuclides in the most consumed teas in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Roberto C. da; Garcêz, Ricardo W.D.; Lopes, José M.; Silva, Ademir X. da, E-mail: robertofisica2012@hotmail.com [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2017-07-01

    Tea is widely consumed worldwide and it is a drink prepared by infusing with parts of plants such as leaves, flowers and roots, usually prepared with hot water, and each variety acquires a defined flavor according to the processing used. This work presents an investigation about the specific concentration of {sup 40}K in 16 tea samples utilized by Brazilian population and the effective dose associated. The tea samples were dried for six hours in an oven at 60°C and placed in 200 ml volume polyethylene pots of low radioactive background, weighed with a scale model Gehaka BG 4000 and sealed to achieve the secular radioactive equilibrium condition. The teas samples were measured using gamma spectroscopy technique with a high-purity germanium (HPGe) detector, a non-destructive nuclear method and with the LabSOCS software for the calculation of the efficiency curve. The counting time used for sample spectrum acquisition was 30000 seconds. The specific concentration values of potassium 40 ranged from 184 ± 56 Bq/kg Lemon Grass (Cymbopogon citrates) to 1087 ± 40 Bq/kg Burdock (Arctium lappa), Effective doses ranged from 1.1408 μSv/y by 6.7394 μSv/y. The values presented in this study were below the annual average for effective dose for ingestion for adults. (author)

  5. Analysis of Antibody Aggregate Content at Extremely High Concentrations Using Sedimentation Velocity with a Novel Interference Optics

    Science.gov (United States)

    Schilling, Kristian; Krause, Frank

    2015-01-01

    Monoclonal antibodies represent the most important group of protein-based biopharmaceuticals. During formulation, manufacturing, or storage, antibodies may suffer post-translational modifications altering their physical and chemical properties. Such induced conformational changes may lead to the formation of aggregates, which can not only reduce their efficiency but also be immunogenic. Therefore, it is essential to monitor the amount of size variants to ensure consistency and quality of pharmaceutical antibodies. In many cases, antibodies are formulated at very high concentrations > 50 g/L, mostly along with high amounts of sugar-based excipients. As a consequence, all routine aggregation analysis methods, such as size-exclusion chromatography, cannot monitor the size distribution at those original conditions, but only after dilution and usually under completely different solvent conditions. In contrast, sedimentation velocity (SV) allows to analyze samples directly in the product formulation, both with limited sample-matrix interactions and minimal dilution. One prerequisite for the analysis of highly concentrated samples is the detection of steep concentration gradients with sufficient resolution: Commercially available ultracentrifuges are not able to resolve such steep interference profiles. With the development of our Advanced Interference Detection Array (AIDA), it has become possible to register interferograms of solutions as highly concentrated as 150 g/L. The other major difficulty encountered at high protein concentrations is the pronounced non-ideal sedimentation behavior resulting from repulsive intermolecular interactions, for which a comprehensive theoretical modelling has not yet been achieved. Here, we report the first SV analysis of highly concentrated antibodies up to 147 g/L employing the unique AIDA ultracentrifuge. By developing a consistent experimental design and data fit approach, we were able to provide a reliable estimation of the minimum

  6. Analysis of antibody aggregate content at extremely high concentrations using sedimentation velocity with a novel interference optics.

    Directory of Open Access Journals (Sweden)

    Kristian Schilling

    Full Text Available Monoclonal antibodies represent the most important group of protein-based biopharmaceuticals. During formulation, manufacturing, or storage, antibodies may suffer post-translational modifications altering their physical and chemical properties. Such induced conformational changes may lead to the formation of aggregates, which can not only reduce their efficiency but also be immunogenic. Therefore, it is essential to monitor the amount of size variants to ensure consistency and quality of pharmaceutical antibodies. In many cases, antibodies are formulated at very high concentrations > 50 g/L, mostly along with high amounts of sugar-based excipients. As a consequence, all routine aggregation analysis methods, such as size-exclusion chromatography, cannot monitor the size distribution at those original conditions, but only after dilution and usually under completely different solvent conditions. In contrast, sedimentation velocity (SV allows to analyze samples directly in the product formulation, both with limited sample-matrix interactions and minimal dilution. One prerequisite for the analysis of highly concentrated samples is the detection of steep concentration gradients with sufficient resolution: Commercially available ultracentrifuges are not able to resolve such steep interference profiles. With the development of our Advanced Interference Detection Array (AIDA, it has become possible to register interferograms of solutions as highly concentrated as 150 g/L. The other major difficulty encountered at high protein concentrations is the pronounced non-ideal sedimentation behavior resulting from repulsive intermolecular interactions, for which a comprehensive theoretical modelling has not yet been achieved. Here, we report the first SV analysis of highly concentrated antibodies up to 147 g/L employing the unique AIDA ultracentrifuge. By developing a consistent experimental design and data fit approach, we were able to provide a reliable

  7. Uranium-238 and thorium-232 series concentrations in soil, radon-222 indoor and drinking water concentrations and dose assessment in the city of Alameda, Chihuahua, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Colmenero Sujo, L.; Montero Cabrera, M.E. E-mail: elena.montero@cimav.edu.mx; Villalba, L.; Renteria Villalobos, M.; Torres Moye, E.; Garcia Leon, M.; Garcia-Tenorio, R.; Mireles Garcia, F.; Herrera Peraza, E.F.; Sanchez Aroche, D

    2004-07-01

    High-resolution gamma spectrometry was used to determine the concentration of {sup 40}K, {sup 238}U and {sup 232}Th series in soil samples taken from areas surrounding the city of Aldama, in Chihuahua. Results of indoor air short-time sampling, with diffusion barrier charcoal detectors, revealed relatively high indoor radon levels, ranging from 29 to 422 Bq/m{sup 3}; the radon concentrations detected exceeded 148 Bq/m{sup 3} in 76% of the homes tested. Additionally, liquid scintillation counting showed concentrations of radon in drinking water ranging from 4.3 to 42 kBq/m{sup 3}. The high activity of {sup 238}U in soil found in some places may be a result of the uranium milling process performed 20 years ago in the area. High radon concentrations indoor and in water may be explained by assuming the presence of uranium-bearing rocks underneath of the city, similar to a felsic dike located near Aldama. The estimated annual effective dose of gamma radiation from the soil and radon inhalation was 3.83 mSv.

  8. Concentrated Solar Thermoelectric Power

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Gang [MIT; Ren, Zhifeng [University of Houston

    2015-07-09

    The goal of this project is to demonstrate in the lab that solar thermoelectric generators (STEGs) can exceed 10% solar-to-electricity efficiency, and STEGs can be integrated with phase-change materials (PCM) for thermal storage, providing operation beyond daylight hours. This project achieved significant progress in many tasks necessary to achieving the overall project goals. An accurate Themoelectric Generator (TEG) model was developed, which included realistic treatment of contact materials, contact resistances and radiative losses. In terms of fabricating physical TEGs, high performance contact materials for skutterudite TE segments were developed, along with brazing and soldering methods to assemble segmented TEGs. Accurate measurement systems for determining device performance (in addition to just TE material performance) were built for this project and used to characterize our TEGs. From the optical components’ side, a spectrally selective cermet surface was developed with high solar absorptance and low thermal emittance, with thermal stability at high temperature. A measurement technique was also developed to determine absorptance and total hemispherical emittance at high temperature, and was used to characterize the fabricated spectrally selective surfaces. In addition, a novel reflective cavity was designed to reduce radiative absorber losses and achieve high receiver efficiency at low concentration ratios. A prototype cavity demonstrated that large reductions in radiative losses were possible through this technique. For the overall concentrating STEG system, a number of devices were fabricated and tested in a custom built test platform to characterize their efficiency performance. Additionally, testing was performed with integration of PCM thermal storage, and the storage time of the lab scale system was evaluated. Our latest testing results showed a STEG efficiency of 9.6%, indicating promising potential for high performance concentrated STEGs.

  9. Vapor concentration monitor

    Science.gov (United States)

    Bayly, John G.; Booth, Ronald J.

    1977-01-01

    An apparatus for monitoring the concentration of a vapor, such as heavy water, having at least one narrow bandwidth in its absorption spectrum, in a sample gas such as air. The air is drawn into a chamber in which the vapor content is measured by means of its radiation absorption spectrum. High sensitivity is obtained by modulating the wavelength at a relatively high frequency without changing its optical path, while high stability against zero drift is obtained by the low frequency interchange of the sample gas to be monitored and of a reference sample. The variable HDO background due to natural humidity is automatically corrected.

  10. Fixed solar energy concentrator

    Energy Technology Data Exchange (ETDEWEB)

    Houghton, A.J.; Knasel, T.M.

    1981-01-20

    An apparatus for the concentration of solar energy upon a fixed array of solar cells is disclosed. A transparent material is overlayed upon the cell array, and a diffuse reflective coating is applied to the surface area of the transparent medium in between cells. Radiant light, which reflects through the transparent layer and does not fall directly incident to a cell surface is reflected by the coating layer in an approximate cosine pattern. Thereafter, such light undergoes internal reflection and rediffusion until subsequently it either strikes a solar cell surface or is lost through the upper surface of the transparent material.

  11. Theory of Concentrated Vortices

    DEFF Research Database (Denmark)

    Alekseenko, Sergey; Kuibin, Pavel; Okulov, Valery

    This book presents comprehensive and authoritative coverage of the wide field of concentrated vortices observed in nature and technique. The methods for research of their kinematics and dynamics are considered. Special attention is paid to the flows with helical symmetry. The authors have describ...... models of vortex structures used for interpretation of experimental data which serve as a ground for development of theoretical and numerical approaches to vortex investigation. Achievements in the fields of stability analysis, waves on vortices and vortex breakdown are also presented....

  12. Optical oxygen concentration monitor

    Science.gov (United States)

    Kebabian, Paul

    1997-01-01

    A system for measuring and monitoring the concentration of oxygen uses as a light source an argon discharge lamp, which inherently emits light with a spectral line that is close to one of oxygen's A-band absorption lines. In a preferred embodiment, the argon line is split into sets of components of shorter and longer wavelengths by a magnetic field of approximately 2000 Gauss that is parallel to the light propagation from the lamp. The longer wavelength components are centered on an absorption line of oxygen and thus readily absorbed, and the shorter wavelength components are moved away from that line and minimally absorbed. A polarization modulator alternately selects the set of the longer wavelength, or upshifted, components or the set of the shorter wavelength, or downshifted, components and passes the selected set to an environment of interest. After transmission over a path through that environment, the transmitted optical flux of the argon line varies as a result of the differential absorption. The system then determines the concentration of oxygen in the environment based on the changes in the transmitted optical flux between the two sets of components. In alternative embodiments modulation is achieved by selectively reversing the polarity of the magnetic field or by selectively supplying the magnetic field to either the emitting plasma of the lamp or the environment of interest.

  13. concentrate ratio and rumen ammonia concentration on in situ

    African Journals Online (AJOL)

    Roffler, 1975; Roffler et al., 1976) for maximum microbial protein synthesis. Volatile fatty acid concentrations in rumen fluid were not affected by rumen ammonia concentration (P,> 0.05), but the concentration of propionic acid increased (P < 0.05) as dietary roughage was replac"d by concentrate, and acelate concentra-.

  14. Tirdzniecības stratēģiju izvēle atkarībā no valūtu pāra svārstību intensitātes

    OpenAIRE

    Proskurovs, Vladlens

    2010-01-01

    Darba autors izvirzīja mērķi izanalizēt noteiktu indikatoru efektivitāti tirdzniecībā ar valūtas pāriem atkarībā no svārstību intensitātes pakāpes, lai piedāvātu optimālu stratēģiju individuālam investoram, kas vēlas darboties FOREX tirgū. Šim nolūkam, pirmkārt, tika apskatīta FOREX tirgus vēsture, būtība un dalībnieki; otrkārt, izpētīti divi galvenie tirgus analīzes veidi; treškārt, aprakstīts tāds tirgus indikators kā slīdošie vidējie, ar kuras palīdzību ir izveidotas tirdzniecības stratēģi...

  15. Návrh nového řešení těsnění nastavovacího šroubu světlometu

    OpenAIRE

    Lysa, Bohuslav

    2008-01-01

    Bakalářská práce zabývající se problematikou těsnění nastavovacího šroubu světlometu. Obsahuje analýzu uložení těsnícího O-kroužku a analýzu zajištění nastavovacího šroubu v pracovní pozici. Na základě analýzy je vypracován nový návrh rozměrového uložení těsnícího O-kroužku, a nový návrh zajištění nastavovacího šroubu. Vybrané části analýzy byly ověřeny výpočtovými simulacemi MKP v programu SimDesigner využívající 3D modely zpracované v CAD systému Catia v5. Součástí práce je studie provedite...

  16. Concentrating Solar Power

    Energy Technology Data Exchange (ETDEWEB)

    Weinstein, Lee A.; Loomis, James; Bhatia, Bikram; Bierman, David M.; Wang, Evelyn N.; Chen, Gang

    2015-12-09

    Solar energy is a bountiful renewable energy resource: the energy in the sunlight that reaches Earth in an hour exceeds the energy consumed by all of humanity in a year.(1) While the phrase “solar energy conversion” probably brings photovoltaic (PV) cells to mind first, PV is not the only option for generating electricity from sunlight. Another promising technology for solar energy conversion is solar–thermal conversion, commonly referred to as concentrating solar power (CSP).(2) The first utility-scale CSP plants were constructed in the 1980s, but in the two decades that followed, CSP saw little expansion.(3, 4) More recent years, however, have seen a CSP renaissance due to unprecedented growth in the adoption of CSP.(3, 5) Photographs of two operating CSP plants, a parabolic trough collector plant and a central receiver (or “power tower”), are shown here.

  17. Concentrating Solar Power

    Science.gov (United States)

    Mehos, Mark

    2008-09-01

    Concentrating Solar Power (CSP) has the potential to contribute significantly to the generation of electricity by renewable energy resources in the U.S.. Thermal storage can extend the duty cycle of CSP beyond daytime hours to early evening where the value of electricity is often the highest. The potential solar resource for the southwest U.S. is identified, along with the need to add power lines to bring the power to consumers. CSP plants in the U.S. and abroad are described. The CSP cost of electricity at the busbar is discussed. With current incentives, CSP is approaching competiveness with conventional gas-fired systems during peak-demand hours when the price of electricity is the highest. It is projected that a mature CSP industry of over 4 GWe will be able to reduce the energy cost by about 50%, and that U.S. capacity could be 120 GW by 2050.

  18. Stress concentration at notches

    CERN Document Server

    Savruk, Mykhaylo P

    2017-01-01

    This book compiles solutions of linear theory of elasticity problems for isotropic and anisotropic bodies with sharp and rounded notches. It contains an overview of established and recent achievements, and presents the authors’ original solutions in the field considered with extensive discussion. The volume demonstrates through numerous, useful examples the effectiveness of singular integral equations for obtaining exact solutions of boundary problems of the theory of elasticity for bodies with cracks and notches. Incorporating analytical and numerical solutions of the problems of stress concentrations in solid bodies with crack-like defects, this volume is ideal for scientists and PhD students dealing with the problems of theory of elasticity and fracture mechanics. Stands as a modern and extensive compendium of solutions to the problems of linear theory of elasticity of isotropic and anisotropic bodies with sharp and rounded notches; Adopts a highly reader-friendly layout of tables, charts, approximation ...

  19. Concentrating solar thermal power.

    Science.gov (United States)

    Müller-Steinhagen, Hans

    2013-08-13

    In addition to wind and photovoltaic power, concentrating solar thermal power (CSP) will make a major contribution to electricity provision from renewable energies. Drawing on almost 30 years of operational experience in the multi-megawatt range, CSP is now a proven technology with a reliable cost and performance record. In conjunction with thermal energy storage, electricity can be provided according to demand. To date, solar thermal power plants with a total capacity of 1.3 GW are in operation worldwide, with an additional 2.3 GW under construction and 31.7 GW in advanced planning stage. Depending on the concentration factors, temperatures up to 1000°C can be reached to produce saturated or superheated steam for steam turbine cycles or compressed hot gas for gas turbine cycles. The heat rejected from these thermodynamic cycles can be used for sea water desalination, process heat and centralized provision of chilled water. While electricity generation from CSP plants is still more expensive than from wind turbines or photovoltaic panels, its independence from fluctuations and daily variation of wind speed and solar radiation provides it with a higher value. To become competitive with mid-load electricity from conventional power plants within the next 10-15 years, mass production of components, increased plant size and planning/operating experience will be accompanied by technological innovations. On 30 October 2009, a number of major industrial companies joined forces to establish the so-called DESERTEC Industry Initiative, which aims at providing by 2050 15 per cent of European electricity from renewable energy sources in North Africa, while at the same time securing energy, water, income and employment for this region. Solar thermal power plants are in the heart of this concept.

  20. Světový trh kakaa

    OpenAIRE

    Voglová, Karolína

    2014-01-01

    This bachelor thesis deals with the global cocoa market. The aim of this thesis is to analyse the global cocoa market and indentify the future prospects of this market. The first chapter deals with the general charakteristics of this commodity, i.e. the history of cocoa growing, types of cocoa, cocoa cultivation and cocoa producing areas, and it is processed by using the methods of synthesis and comparison. Another chapter is the analysis of the global cocoa market, which presents the greates...

  1. Svær asthma bronchiale

    DEFF Research Database (Denmark)

    von Bülow, Anna; Backer, Vibeke; Porsbjerg, Celeste

    2015-01-01

    Severe asthma is defined by persistent symptoms and frequent exacerbations despite intensive asthma therapy. The prevalence is estimated to be 5-10% of all asthmatics. Severe asthma is responsible for a major burden of illness including low quality of life and a disproportionate use of health......-care resources. The clinical assessment of severe asthma must include verification of the correct diagnosis, adherence to medication, excluding differential diagnosis and identification and treatment of aggravating co-morbidities and trigger factors....

  2. Så faldt Damokles-sværdet!

    DEFF Research Database (Denmark)

    Fledelius, Karsten

    2013-01-01

    En i udlandet stærkt kritiseret russisk lov om registrering af NGOer, herunder selvangivelse som "udenlandske agent" hvis man modtager støtte fra udlandet, er nu sat i fuld gang, trods kritik bl.a. af den tyske kansler Angela Merkel...

  3. 232Th, 238U, 40K, 137Cs radioactivity concentrations and 137Cs dose rate in Turkish market tea

    Science.gov (United States)

    Kiliç, Önder; Belivermiş, Murat; Topcuoǧlu, Sayhan; Çotuk, Yavuz

    In this study, the activity concentrations of 232Th, 238U, 40K and 137Cs were measured in 10 branded tea samples from local Turkish markets using gamma spectrometry with an HPGe detector. The mean activity concentrations of 232Th, 238U, 40K and 137Cs were found to be 2.7 ± 1.0, 0.9 ± 0.4, 501 ± 42 and 45.04 ± 2.6 Bq kg-1, respectively. The average annual effective 137Cs dose as a consequence of tea consumption was found to be 385 nSv for an adult person, which is not hazardous to public health. The correlation coefficient between 137Cs and 40K was found to be-0.82 in these samples. The present data were compared with those found in other studies.

  4. Workplace Concentration of Immigrants

    Science.gov (United States)

    Andersson, Fredrik; García-Pérez, Mónica; Haltiwanger, John; McCue, Kristin; Sanders, Seth

    2014-01-01

    Casual observation suggests that in most U.S. urban labor markets, immigrants have more immigrant coworkers than native-born workers do. While seeming obvious, this excess tendency to work together has not been precisely measured, nor have its sources been quantified. Using matched employer–employee data from the U.S. Census Bureau Longitudinal Employer-Household Dynamics (LEHD) database on a set of metropolitan statistical areas (MSAs) with substantial immigrant populations, we find that, on average, 37% of an immigrant’s coworkers are themselves immigrants; in contrast, only 14% of a native-born worker’s coworkers are immigrants. We decompose this difference into the probability of working with compatriots versus with immigrants from other source countries. Using human capital, employer, and location characteristics, we narrow the mechanisms that might explain immigrant concentration. We find that industry, language, and residential segregation collectively explain almost all the excess tendency to work with immigrants from other source countries, but they have limited power to explain work with compatriots. This large unexplained compatriot component suggests an important role for unmeasured country-specific factors, such as social networks. PMID:25425452

  5. Concentrations of Radiocesium in Local Foods Collected in Kawauchi Village after the Accident at the Fukushima Dai-ichi Nuclear Power Station

    Science.gov (United States)

    Orita, Makiko; Nakashima, Kanami; Hayashida, Naomi; Endo, Yuuko; Yamashita, Shunichi; Takamura, Noboru

    2016-06-01

    We evaluated the current concentrations of radiocesium in local foods collected in Kawauchi Village, which is located less than 30 km from Fukushima Daiichi Nuclear Power Station, to minimize public anxiety regarding internal radiation exposure through the consumption of locally produced foods after the 2011 Fukushima accident. The number of samples exceeding the regulatory radiocesium limit (100 Bq/kg for general foods) was five out of 4,080 vegetables (0.1%), 652 of 1,986 (32.8%) among edible wild plants and fungi, and eight of 647 (1.2%) in fruits. Our study confirmed that the internal radiation doses of ingesting these foods are acceptably low compared to the public dose limit, ranging from 24.4 to 42.7 μSv for males and from 21.7 to 43.4 μSv for females, although the potential for radiation exposure still exists. Long-term comprehensive follow-up should take place to clarify trends in radiocesium concentrations in local foods and the committed effective doses found in Fukushima-area residents. By constructing a system that allows residents to access information on radiocesium concentration in foods, a risk communication model between specialists and residents could be developed in the recovery phase after the Fukushima accident.

  6. {sup 210}Po and {sup 210}Pb concentration of cigarettes traded in Hungary and their estimated dose contribution due to smoking

    Energy Technology Data Exchange (ETDEWEB)

    Kovacs, Tibor [Department of Radiochemistry, University of Pannonia, P.O. Box 158, H-8201 Veszprem (Hungary)], E-mail: kt@almos.vein.hu; Somlai, Janos [Department of Radiochemistry, University of Pannonia, P.O. Box 158, H-8201 Veszprem (Hungary); Nagy, Katalin [Department of Rheumatology, Markhot F. Heves County Hospital, Szechenyi ut 27, H-3300 Eger (Hungary); Szeiler, Gabor [Department of Radiochemistry, University of Pannonia, P.O. Box 158, H-8201 Veszprem (Hungary)

    2007-11-15

    It is known that tobacco leaves may contain {sup 210}Pb and {sup 210}Po in significant concentrations. The cumulative alpha-radiation dose due to the radioactive content of inhaled cigarette smoke and the increasing number of lung cancer cases explain the importance of the investigation. The present study investigated the activity concentrations of these two radionuclides in 29 Hungarian cigarette samples. The relation between {sup 210}Po/{sup 210}Pb activity and nicotine/tar content of these cigarettes was also examined. {sup 210}Po was determined by alpha spectrometry using a PIPS detector after chemical leaching and spontaneous deposition of {sup 210}Po on a high nickel-content (25%) stainless steel disk. The {sup 210}Pb activity was calculated from the {sup 210}Po originated from the decay of {sup 210}Pb after a waiting period of eight months. The {sup 210}Po activity concentrations of the measured types of cigarettes ranged from 10.0 to 33.5 mBq/cigarette, and the activity of {sup 210}Pb varied from 9.6 to 32.5 mBq/cigarette. The average annual committed effective dose is estimated to be 185.6{+-}70.6{mu}Sv/y and 58.7{+-}22.7{mu}Sv/y due to cigarette smoking (20 cigarettes/day) for {sup 210}Po and {sup 210}Pb, respectively.

  7. Mineralogical controls on antimony and arsenic mobility during tetrahedrite-tennantite weathering at historic mine sites Špania Dolina-Piesky and Lubietová-Svätodušná, Slovakia

    Energy Technology Data Exchange (ETDEWEB)

    Bor,; #269; inová rAdková, AnežkA; Jamieson, Heather; Lalinská-Voleková, Bronislava; Majzlan, Juraj; Števko, Martin; Chovan, Martin

    2018-01-01

    The legacy of copper (Cu) mining at Špania Dolina-Piesky and Lubietová-Svätodušná (central Slovakia) is waste rock and soil, surface waters, and groundwaters contaminated with antimony (Sb), arsenic (As), Cu, and other metals. Copper ore is hosted in chalcopyrite (CuFeS2) and sulfosalt solid-solution tetrahedrite-tennantite {Cu6[Cu4(Fe,Zn)2]Sb4S13–Cu6[Cu4(Fe,Zn)2]As4S13} that show wide-spread oxidation characteristic by olive-green color secondary minerals. Tetrahedrite-tennantite can be a significant source of As and Sb contamination. Synchrotron-based μ-XRD, μ-XRF, and μ-XANES combined with electron microprobe analyses have been used to determine the mineralogy, chemical composition, element distribution, and Sb speciation in tetrahedrite-tennantite oxidation products in waste rock. Our results show that the mobility of Sb is limited by the formation of oxidation products such as tripuhyite and roméite group mineral containing 36.54 wt% Sb for samples where the primary mineral chemical composition is close to tetrahedrite end-member. Antimony K-edge μ-XANES spectra of these oxidation products indicate that the predominant Sb oxidation state is 5+. Arsenic and Cu are also hosted by amorphous phases containing 6.23 wt% Sb on average and these are intergrown with tripuhyite and roméite. Antimony in this environment is not very mobile, meaning it is not easily released from solid phases to water, especially compared to As, Cu, and S. For samples where the primary sulfosalt is close to tennantite composition, the oxidation products associated with tennantite relicts contain 2.43 wt% Sb and are amorphous. The variable solubility of the secondary minerals that have been identified is expected to influence mobility of Sb and As in near-surface environment.

  8. The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals.

    Science.gov (United States)

    Ceder, Rebecca; Merne, Marina; Staab, Claudia A; Nilsson, Jan Anders; Höög, Jan-Olov; Dressler, Dirk; Engelhart, Karin; Grafström, Roland C

    2007-12-01

    In vitro models are currently not considered to be suitable replacements for animals in experiments to assess the multiple factors that underlie the development of cancer as a result of environmental exposure to chemicals. An evaluation was conducted on the potential use of normal keratinocytes, the SV40 T-antigen-immortalised keratinocyte cell line, SVpgC2a, and the carcinoma cell line, SqCC/Y1, alone and in combination, and under standardised serum-free culture conditions, to study oral cancer progression. In addition, features considered to be central to cancer development as a result of environmental exposure to chemicals, were analysed. Genomic expression, and enzymatic and functional data from the cell lines reflected many aspects of the transition of normal tissue epithelium, via dysplasia, to full malignancy. The composite cell line model develops aberrances in proliferation, terminal differentiation and apoptosis, in a similar manner to oral cancer progression in vivo. Transcript and protein profiling links aberrations in multiple gene ontologies, molecular networks and tumour biomarker genes (some proposed previously, and some new) in oral carcinoma development. Typical specific changes include the loss of tumour-suppressor p53 function and of sensitivity to retinoids. Environmental agents associated with the aetiology of oral cancer differ in their requirements for metabolic activation, and cause toxic effects to cells in both the normal and the transformed states. The results suggest that the model might be useful for studies on the sensitivity of cells to chemicals at different stages of cancer progression, including many aspects of the integrated roles of cytotoxicity and genotoxicity. Overall, the properties of the SVpgC2a and SqCC/Y1 cell lines, relative to normal epithelial cells in monolayer or organotypic culture, support their potential applicability to mechanistic studies on cancer risk factors, including, in particular, the definition of

  9. Conical electromagnetic radiation flux concentrator

    Science.gov (United States)

    Miller, E. R.

    1972-01-01

    Concentrator provides method of concentrating a beam of electromagnetic radiation into a smaller beam, presenting a higher flux density. Smaller beam may be made larger by sending radiation through the device in the reverse direction.

  10. Membrane distillation for milk concentration

    NARCIS (Netherlands)

    Moejes, S.N.; Romero Guzman, Maria; Hanemaaijer, J.H.; Barrera, K.H.; Feenstra, L.; Boxtel, van A.J.B.

    2015-01-01

    Membrane distillation is an emerging technology to concentrate liquid products while producing high quality water as permeate. Application for desalination has been studied extensively the past years, but membrane distillation has also potential to produce concentrated food products like

  11. High annual radon concentration in dwellings and natural radioactivity content in nearby soil in some rural areas of Kosovo and Metohija

    Directory of Open Access Journals (Sweden)

    Gulan Ljiljana R.

    2013-01-01

    Full Text Available Some previous studies on radon concentration in dwellings of some areas of Kosovo and Metohija have revealed a high average radon concentration, even though the detectors were exposed for three months only. In order to better design a larger study in this region, the annual measurements in 25 houses were carried out as a pilot study. For each house, CR-39-based passive devices were exposed in two rooms for the two consecutive six-month periods to account for seasonal variations of radon concentration. Furthermore, in order to correlate the indoor radon with radium in nearby soil and to improve the knowledge of the natural radioactivity in the region, soil samples near each house were collected and 226Ra, 232Th, 40K activity concentration were measured. The indoor radon concentration resulted quite high from the average (163 Bq/m3 and generally it did not differ considerably between the two rooms and the two six-month periods. The natural radionuclides in soil resulted to be distributed quite uniformly. Moreover, the correlation between the226Ra content in soil and radon concentration in dwellings resulted to be low (R2=0.26. The annual effective dose from radon and its short-lived progeny (5.5 mSv, in average was calculated by using the last ICRP dose conversion factors. In comparison, the contribution to the annual effective dose of outdoor gamma exposure from natural radionuclides in soil is nearly negligible (66 mSv. In conclusion, the observed high radon levels are only partially correlated with radium in soil; moreover, a good estimate of the annual average of radon concentration can be obtained from a six-month measurement with a proper choice of exposure period, which could be useful when designing large surveys.

  12. Microfluidic Techniques for Analytes Concentration

    Directory of Open Access Journals (Sweden)

    Cunlu Zhao

    2017-01-01

    Full Text Available Microfluidics has been undergoing fast development in the past two decades due to its promising applications in biotechnology, medicine, and chemistry. Towards these applications, enhancing concentration sensitivity and detection resolution are indispensable to meet the detection limits because of the dilute sample concentrations, ultra-small sample volumes and short detection lengths in microfluidic devices. A variety of microfluidic techniques for concentrating analytes have been developed. This article presents an overview of analyte concentration techniques in microfluidics. We focus on discussing the physical mechanism of each concentration technique with its representative advancements and applications. Finally, the article is concluded by highlighting and discussing advantages and disadvantages of the reviewed techniques.

  13. High-efficiency solar concentrator

    Science.gov (United States)

    Lansing, F. L.; Dorman, J.

    1980-01-01

    A new type of solar concentrator is presented using liquid lenses and simple translational tracking mechanism. The concentrator achieves a 100:1 nominal concentration ratio and is compared in performance with a flat-plate collector having two sheets of glazing and non-selective coating. The results of the thermal analysis show that higher temperatures can be obtained with the concentrator than is possible with the non-concentrator flat-plate type. Furthermore, the thermal efficiency far exceeds that of the comparative flat-plate type for all operating conditions.

  14. Effects of Using Light-Weight Concrete on Indoor Radon Concentration in High-Rise Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Yu, K.N.; Cheung, T.; Koo, S.Y

    1999-07-01

    Light-weight concrete (LWC) (or drywall construction) has been used for partition walls in public housing in Hong Kong for about 10 years. A previous laboratory investigation showed that all types of LWC had considerably smaller Rn exhalation rates than those from normal concrete (NC), and could thus theoretically reduce the indoor Rn concentrations and the corresponding radiation dose from Rn. In the present investigation, a survey of Rn exhalation rates and indoor Rn concentrations at 39 dwelling sites built using LWC were carried out using charcoal canisters and {gamma}-spectroscopy. The mean Rn exhalation rate and the mean Rn concentration were around 1.6 mBq.s{sup -1}.m{sup -2} and 19 Bq.m{sup -3}, respectively, which were significantly smaller thanthe corresponding values of 12 mBq.s{sup -1}.m{sup -2} and 33 Bq.m{sup -3} for NC sites. The statistical t-test showed that both the mean Rn exhalation rate and the mean Rn concentration for NC and LWC sites walls were different at the 100% confidence level. The Rn exhalation rate from an LWC surface was, on average, only about 14% of that from an NC surface, while the Rn concentration in an LWC site was, on average, about 58% of that in an NC site, which were significant. A person living at an LWC site receives an average annual equivalent dose smaller than one living at an NC site by an amount as large as 1 mSv. Therefore, the use of LWC for partition walls can be a simple and economical way to reduce the indoor Rn concentrations and the corresponding radiation dose from Rn. Furthermore, the mean Rn concentration theoretically predicted from the mean Rn exhalation rate agreed excellently with that from measurements. (author)

  15. Radioactivity concentrations and dose assessment for soil samples around nuclear power plant IV in Taiwan.

    Science.gov (United States)

    Tsai, Tsuey-Lin; Lin, Chun-Chih; Wang, Tzu-Wen; Chu, Tieh-Chi

    2008-09-01

    Activity concentrations and distributions of natural and man-made radionuclides in soil samples collected around nuclear power plant IV, Taiwan, were investigated for five years to assess the environmental radioactivity and characterisation of radiological hazard prior to commercial operation. The activity concentrations of radionuclides were determined via gamma-ray spectrometry using an HPGe detector. Data obtained show that the average concentrations of the (238)U and (232)Th series, and (40)K, were within world median ranges in the UNSCEAR report. The (137)Cs ranged from 2.46 +/- 0.55 to 12.13 +/- 1.31 Bq kg(-1). The terrestrial absorbed dose rate estimated by soil activity and directly measured with a thermoluminescence dosemeter (excluding cosmic rays), and the annual effective doses, were 45.63, 57.34 nGy h(-1) and 57.19 microSv, respectively. Experimental results were compared with international recommended values. Since the soil in this area is an important building material, the mean radium equivalent activity, external and inhalation hazard indices and the representative level index using various models given in the literature for the study area were 98.18 Bq kg(-1), 0.27, 0.34 and 0.73, respectively, which were below the recommended limits. Analytical results demonstrate that no radiological anomaly exists. The baseline data will prove useful and important in estimating the collective dose near the new nuclear power plant under construction in Taiwan.

  16. Estimation of radon concentration in soil and groundwater samples of Northern Rajasthan, India

    Directory of Open Access Journals (Sweden)

    Sudhir Mittal

    2016-04-01

    Full Text Available In the present investigation, analysis of radon concentration in 20 water and soil samples collected from different locations of Bikaner and Jhunjhunu districts of Rajasthan, India has been carried out by using RAD7 an electronic Radon detector. The measured radon concentration in water samples lies in the range from 0.50 to 22 Bq l−1 with the mean value of 4.42 Bq l−1, which lies within the safe limit from 4 to 40 Bq l−1 recommended by United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR, 2008. The total annual effective dose estimated due to radon concentration in water ranges from 1.37 to 60.06 μSV y−1 with the mean value of 12.08 μSV y−1, which is lower than the safe limit 0.1 mSv y−1 as set by World Health Organization (WHO, 2004 and European Council (EU, 1998. Radon measurement in soil samples varies from 941 to 10,050 Bq m−3 with the mean value of 4561 Bq m−3, which lies within the range reported by other investigators. It was observed that the soil and water of Bikaner and Jhunjhunu districts are suitable for drinking and construction purpose without posing any health hazard.

  17. Optimal concentrations in transport systems

    OpenAIRE

    Kim, Wonjung; Bush, John W. M.; Jensen, Kaare H.; Holbrook, N. Michele

    2013-01-01

    Many biological and man-made systems rely on transport systems for the distribution of material, for example matter and energy. Material transfer in these systems is determined by the flow rate and the concentration of material. While the most concentrated solutions offer the greatest potential in terms of material transfer, impedance typically increases with concentration, thus making them the most difficult to transport. We develop a general framework for describing systems for which impeda...

  18. Utility-scale photovoltaic concentrators

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2009-01-18

    The photovoltaics concentrators section of the Renewable Energy Technology Characterizations describes the technical and economic status of this emerging renewable energy option for electricity supply.

  19. Concentrating solar collector - final design

    Science.gov (United States)

    Parker, J. C.

    1980-01-01

    Final report of program to improve commercially available concentrating solar collector describes final hardware, discusses problems encountered, and presents certification statements, photographs, and recommendations for modification.

  20. On Shaft Fillet Stress Concentration

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard

    2017-01-01

    A shaft is typically loaded by three different load types; torsional, bending and normal load separately or more generally in combinations. In most cases the size of the shaft is controlled by the constraints on the maximum allowable deflection and/orrotation at e.g. the position of bearings or g...... or gears. But if care is not taken to limit the stress concentrations these will control the durability of the shaft. With the use of fillets we have stress concentration described by the stress concentration factor Kt (theoretic stress concentration factor)....

  1. SITE SPECIFIC REFERENCE PERSON PARAMETERS AND DERIVED CONCENTRATION STANDARDS FOR THE SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, T.

    2013-03-14

    The purpose of this report is twofold. The first is to develop a set of behavioral parameters for a reference person specific for the Savannah River Site (SRS) such that the parameters can be used to determine dose to members of the public in compliance with Department of Energy (DOE) Order 458.1 “Radiation Protection of the Public and the Environment.” A reference person is a hypothetical, gender and age aggregation of human physical and physiological characteristics arrived at by international consensus for the purpose of standardizing radiation dose calculations. DOE O 458.1 states that compliance with the annual dose limit of 100 mrem (1 mSv) to a member of the public may be demonstrated by calculating the dose to the maximally exposed individual (MEI) or to a representative person. Historically, for dose compliance, SRS has used the MEI concept, which uses adult dose coefficients and adult male usage parameters. Beginning with the 2012 annual site environmental report, SRS will be using the representative person concept for dose compliance. The dose to a representative person will be based on 1) the SRS-specific reference person usage parameters at the 95th percentile of appropriate national or regional data, which are documented in this report, 2) the reference person (gender and age averaged) ingestion and inhalation dose coefficients provided in DOE Derived Concentration Technical Standard (DOE-STD-1196-2011), and 3) the external dose coefficients provided in the DC_PAK3 toolbox. The second purpose of this report is to develop SRS-specific derived concentration standards (DCSs) for all applicable food ingestion pathways, ground shine, and water submersion. The DCS is the concentration of a particular radionuclide in water, in air, or on the ground that results in a member of the public receiving 100 mrem (1 mSv) effective dose following continuous exposure for one year. In DOE-STD-1196-2011, DCSs were developed for the ingestion of water, inhalation of

  2. School concentration and school travel

    NARCIS (Netherlands)

    De Boer, E.

    2010-01-01

    The purpose of the research as described in this Doctor’s thesis is twofold. Firstly it is to define in how far Dutch facilities for primary and secondary education were subjected to spatial concentration during recent decades. Secondly it is intended to assess what this concentration implied for

  3. Concentrations of Polychlorinated Biphenyls (PCBs ...

    African Journals Online (AJOL)

    MICHAEL

    ABSTRACT: Concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), and polybrominated diphenyl ethers (PBDEs) were examined as a function of depth in killer whale (Orcinus orca) blubber samples. Lipid-normalized concentrations of PCBs, PCDD/Fs, and ...

  4. Extremely high radon activity concentration in two adits of the abandoned uranium mine 'Podgórze' in Kowary (Sudety Mts., Poland).

    Science.gov (United States)

    Fijałkowska-Lichwa, Lidia

    2016-12-01

    Measurements of radon activity concentration were conducted for a period of 6 months, from April to September 2011, in the air of two adits constituting part of the disused uranium mine 'Podgórze' in Kowary. Adits no. 19 and 19a in Kowary had been chosen owing to the occurrence within them of the highest documented radon concentrations in Poland, With levels higher than a million Bq m-3. The main goal of this study was to characterize the level of 222Rn activity concentration registered in selected workings of this underground space, investigate 222Rn changes and their characteristics over selected periods of time (an hour, a day, a month, six months) and determine the effective doses, which provided the basis for estimating the risk of exposure to increased ionizing radiation for employees and visitors to the mine. The highest values of 222Rn activity concentration inside the adits occurred at the time when visitors, guides and other members of the staff were present there. The recorded values of radon activity concentration, regardless of the time and the month when the measurement was performed, remained at an average level of 350-400 kBq m-3. These values were far above the limit of 1.5 kBq·m-3 recommended by international guidelines. The maximum values ranged from 800 to more than 1000 kBq·m-3. Radon activity concentration changes occurred only in periods determined by 7-h cycles of connecting and disconnecting the mechanical ventilation. For about 7 h after activating the ventilation system, between 7 a. m. and 2 p. m., and after closing the adit, between 7 p. m. and 2 a. m., 222Rn activity concentrations decreased to levels even as low as 100 kBq·m-3. However, as early as 3-4 h after disconnecting the ventilation system, there was a sharp rise in the values of 222Rn activity concentration, to the level higher than 800 kBq·m-3. The risk of receiving a radiation dose higher than the national standard of 1 mSv/year by members of the public

  5. A novel way to monitor urine concentration: fluorescent concentration matrices.

    Science.gov (United States)

    Dubayova, Katarina; Luckova, Iveta; Sabo, Jan; Karabinos, Anton

    2015-01-01

    The amount of water found in urine is important diagnostic information; nevertheless it is not yet directly determined. Indirectly, the water content in urine is expressed by its density (specific gravity). However, without the diuresis value it is not possible to determine whether the increase in density of urine is due to a decrease in water secretion or an increase in the concentration of secreted substances. This problem can be solved by the use of fluorescent concentration 3D-matrices which characterise urine concentration through the pφ (or -logφ) value of the first fluorescence centre. The urine fluorescent concentration 3D-matrix was created by the alignment of the synchronous spectra of the dilution series of urine starting from undiluted (pφ = 0) to 1000-fold diluted urine (pφ = 3). Using the fluorescence concentration 3D-matrix analysis of the urine samples from healthy individuals, a reference range was established for the value pφ, determining the normal, concentrated or diluted type of urine. The diagnostic potential of this approach was tested on urine samples from two patients with a chronic glomerulonephritis. The pφ value of the urine fluorescence concentration 3D-matrix analysis determines whether the urine sample falls within the normal, concentrated or diluted type of urine. This parameter can be directly utilised in sportsmen's hydration state monitoring, as well as in the diagnosis and treatment of serious diseases. An important advantage of this novel diagnostic approach is that a 12/24 h urine collection is not required, which predetermines it for use especially within paediatrics.

  6. Solar Concentrator Advanced Development Program

    Science.gov (United States)

    Knasel, Don; Ehresman, Derik

    1989-01-01

    The Solar Concentrator Advanced Development Project has successfully designed, fabricated, and tested a full scale prototypical solar dynamic concentrator for space station applications. A Truss Hexagonal Panel reflector was selected as a viable solar concentrator concept to be used for space station applications. This concentrator utilizes a modular design approach and is flexible in attainable flux profiles and assembly techniques. The detailed design of the concentrator, which included structural, thermal and optical analysis, identified the feasibility of the design and specific technologies that were required to fabricate it. The needed surface accuracy of the reflectors surface was found to be very tight, within 5 mrad RMS slope error, and results in very close tolerances for fabrication. To meet the design requirements, a modular structure composed of hexagonal panels was used. The panels, made up of graphite epoxy box beams provided the strength, stiffness and dimensional stability needed. All initial project requirements were met or exceeded by hardware demonstration. Initial testing of structural repeatability of a seven panel portion of the concentrator was followed by assembly and testing of the full nineteen panel structure. The testing, which consisted of theodolite and optical measurements over an assembly-disassembly-reassembly cycle, demonstrated that the concentrator maintained the as-built contour and optical characteristics. The facet development effort within the project, which included developing the vapor deposited reflective facet, produced a viable design with demonstrated optical characteristics that are within the project goals.

  7. Mitragynine concentrations in two fatalities.

    Science.gov (United States)

    Domingo, Olwen; Roider, Gabriele; Stöver, Andreas; Graw, Matthias; Musshoff, Frank; Sachs, Hans; Bicker, Wolfgang

    2017-02-01

    Two cases of fatalities are reported of which the recreational use of Mitragyna speciosa ("kratom") could be confirmed. One of these cases presents with one of the highest postmortem mitragynine concentrations published to date. Our results show that even extremely high mitragynine blood concentrations following the consumption of kratom do not necessarily have to be the direct cause of death in such fatalities as a result of an acute overdose. The two cases are compared with regard to the differences in mitragynine concentrations detected and the role of mitragynine in the death of the subjects. Irrespective of the big differences in mitragynine concentrations in the postmortem blood samples, mitragynine was not the primary cause of death in either of the two cases reported here. Additionally, by rough estimation, a significant difference in ratio of mitragynine to its diastereomers in the blood and urine samples between the two cases could be seen. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  8. Anodic Concentration Polarization in SOFCs

    Energy Technology Data Exchange (ETDEWEB)

    Williford, Rick E.; Chick, Lawrence A.; Maupin, Gary D.; Simner, Steve P.; Stevenson, Jeffry W.; Khaleel, Mohammad A.; Wachsman, ED, et al

    2003-08-01

    Concentration polarization is important because it determines the maximum power output of a solid oxide fuel cell (SOFC) at high fuel utilization. Anodic concentration polarization occurs when the demand for reactants exceeds the capacity of the porous ceramic anode to supply them by gas diffusion mechanisms. High tortuosities (bulk diffusion resistances) are often assumed to explain this behavior. However, recent experiments show that anodic concentration polarization originates in the immediate vicinity of the reactive triple phase boundary (TPB) sites near the anode/electrolyte interface. A model is proposed to describe how concentration polarization is controlled by two localized phenomena: competitive adsorption of reactants in areas adjacent to the reactive TPB sites, followed by relatively slow surface diffusion to the reactive sites. Results suggest that future SOFC design improvements should focus on optimization of the reactive area, adsorption, and surface diffusion at the anode/electrolyte interface.

  9. Freeze concentration of dairy products

    Energy Technology Data Exchange (ETDEWEB)

    Amarnath, K.R. [Electric Power Research Inst., Palo Alto, CA (United States). Systems and Materials Dept.; Swinkels, W. [Holland Energy Technology BV (Netherlands)

    1992-12-31

    Freeze concentration as a separation process was discussed. It separates mixed liquids by converting one or more of them to a solid. The process is more energy efficient in many applications than either evaporation or distillation, the most common industrial separation methods today. An EPRI report has shown that annual heat energy consumption would decrease an estimated 1.4 quads if industry replaced evaporation and distillation in every feasible case where freezing can be used. The freeze concentration process was employed to replace thermal evaporation in the dairy industry. The goals of the project were to save energy by converting concentration processes to an efficient electrically powered refrigeration system, and to create higher quality dairy products. Tests showed equal or superior quality from freeze concentrates. 2 tabs.

  10. Extension of platelet concentrate storage.

    Science.gov (United States)

    Simon, T L; Nelson, E J; Carmen, R; Murphy, S

    1983-01-01

    Extension of the storage time of platelet concentrates in a satellite bag which is part of a new blood bag system was studied by reinfusing autologous 51Cr-labeled platelets into normal volunteers, and measuring postinfusion platelet counts and bleeding times in patients requiring platelet transfusions. This satellite bag, made of polyvinylchloride plasticized with a new agent, was found to protect platelet concentrates against fall of pH better than other containers studied. This protection was felt to be due to the greater gas permeability of the new plastic. Mean in vivo recovery and half-life (greater than 31% and 3.3 days, respectively) of autologous reinfused platelets were satisfactory following 5 days of storage. Following 7 days of storage, mean recovery was 41 percent and half-life was 2.8 days. Peripheral platelet count increments in patients following platelet transfusions with concentrates stored 4 to 7 days in the new plastic were comparable to increments following transfusion of platelets stored 2 to 3 days in the other plastics studied. Bleeding times shortened in three of four patients receiving platelet concentrates stored from 4 to 6 days in the new plastic. Platelet concentrates stored in the new bag at 20 to 24 degrees C with flat-bed or elliptical agitation could be transfused for up to 5 days following phlebotomy with acceptable clinical results. The new plastic container is promising for storage of platelet concentrates for up to 7 days. Due to the higher pH of 50-ml platelet concentrates stored in bags made with the new plastic, the concentrates were superior at any storage interval to those stored in bags made of the other plastics studied.

  11. 13C and 15N CP/MAS, 1H-15N SCT CP/MAS and FTIR spectroscopy as tools for qualitative detection of the presence of zwitterionic and non-ionic forms of ansa-macrolide 3-formylrifamycin SV and its derivatives in solid state.

    Science.gov (United States)

    Przybylski, Piotr; Pyta, Krystian; Klich, Katarzyna; Schilf, Wojciech; Kamieński, Bohdan

    2014-01-01

    (13)C, (15)N CP/MAS, including (1)H-(13)C and (1)H-(15)N short contact time CP/MAS experiments, and FTIR methods were applied for detailed structural characterization of ansa-macrolides as 3-formylrifamycin SV (1) and its derivatives (2-6) in crystal and in powder forms. Although HPLC chromatograms for 2/CH3 OH and 2/CH3 CCl3 were the same for rifampicin crystals dissolved in respective solvents, the UV-vis data recorded for them were different in 300-375 nm region. Detailed solid state (13)C and (15)N CP/MAS NMR and FTIR studies revealed that rifampicin (2), in contrast to 3-formylrifamycin SV (1) and its amino derivatives (3-6), can occur in pure non-ionic or zwitterionic forms in crystal and in pure these forms or a mixture of them in a powder. Multinuclear CP/MAS and FTIR studies demonstrated also that 3-6 derivatives were present exclusively in pure zwitterionic forms, both in powder and in crystal. On the basis of the solid state NMR and FTIR studies, two conformers of 3-formylrifamycin SV were detected in powder form due to the different orientations of carbonyl group of amide moiety. The PM6 molecular modeling at the semi-empirical level of theory, allowed visualization the most energetically favorable non-ionic and zwitterionic forms of 1-6 antibiotics, strongly stabilized via intramolecular H-bonds. FTIR studies indicated that the originally adopted forms of these type antibiotics in crystal or in powder are stable in standard laboratory conditions in time. The results presented point to the fact that because of a possible presence of two forms of rifampicin (compound 2), quantification of the content of this antibiotic in relevant pharmaceuticals needs caution. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Radiological Modeling for Determination of Derived Concentration Levels of an Area with Uranium Residual Material - 13533

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Sanchez, Danyl [CIEMAT, Avenida Complutense 40, 28040, Madrid (Spain)

    2013-07-01

    As a result of a pilot project developed at the old Spanish 'Junta de Energia Nuclear' to extract uranium from ores, tailings materials were generated. Most of these residual materials were sent back to different uranium mines, but a small amount of it was mixed with conventional building materials and deposited near the old plant until the surrounding ground was flattened. The affected land is included in an area under institutional control and used as recreational area. At the time of processing, uranium isotopes were separated but other radionuclides of the uranium decay series as Th-230, Ra-226 and daughters remain in the residue. Recently, the analyses of samples taken at different ground's depths confirmed their presence. This paper presents the methodology used to calculate the derived concentration level to ensure that the reference dose level of 0.1 mSv y-1 used as radiological criteria. In this study, a radiological impact assessment was performed modeling the area as recreational scenario. The modelization study was carried out with the code RESRAD considering as exposure pathways, external irradiation, inadvertent ingestion of soil, inhalation of resuspended particles, and inhalation of radon (Rn-222). As result was concluded that, if the concentration of Ra-226 in the first 15 cm of soil is lower than, 0.34 Bq g{sup -1}, the dose would not exceed the reference dose. Applying this value as a derived concentration level and comparing with the results of measurements on the ground, some areas with a concentration of activity slightly higher than latter were found. In these zones the remediation proposal has been to cover with a layer of 15 cm of clean material. This action represents a reduction of 85% of the dose and ensures compliance with the reference dose. (authors)

  13. Stavudine plasma concentrations and lipoatrophy.

    Science.gov (United States)

    ter Hofstede, Hadewych J M; Koopmans, Peter P; Burger, David M

    2008-04-01

    The objective of this study was to determine the correlation between plasma stavudine concentrations and lipoatrophy (LA), one of the major adverse events in patients on stavudine and one of the major reasons to discontinue stavudine. Plasma drug concentrations were retrospectively analysed in patients who were on a stavudine-containing regimen for at least 12 months. We defined two groups of patients: 21 patients with LA and 15 patients without LA or other stavudine-related side effects (i.e. neuropathy). We analysed stavudine concentrations in 212 plasma samples: 87 in the control group and 125 in the LA group, with a mean of four plasma samples per person (at least two a year). Demographics were comparable in LA patients and controls, except the duration of stavudine use, which was longer in the LA group: 55 versus 42 months in the control group. Overall, LA patients had higher drug exposure to stavudine when compared with the controls, and this was seen in the geometric concentration ratios (CRs), which were 0.978 and 0.741, respectively (P = 0.04), and also a higher percentage of CR values >1.0, representing a drug concentration above the normal population curve (46% versus 23%, P = 0.02). In addition, the duration of stavudine therapy was independently associated with LA (P = 0.05). In the multivariate analysis, both duration of stavudine (P = 0.05) and CR > 1.0 (P = 0.02) were independently correlated with LA. Monitoring of plasma stavudine concentrations can be useful to prevent stavudine-related LA.

  14. Viscoelasticity of Concentrated Proteoglycan Solutions

    Science.gov (United States)

    Meechai, Nispa; Jamieson, Alex; Blackwell, John; Carrino, David

    2001-03-01

    Proteoglycan Aggregate (PGA) is the principal macromolecular component of the energy-absorbing matrix of cartilage and tendon. Its brush-like supramolecular structure consists of highly-ionic subunits, non-covalently bound to a hyaluronate chain. We report viscoelastic behavior of concentrated solutions of PGA, purified by column fractionation to remove free subunits. At physiological ionic strength, these preparations exhibit a sol-to-gel transition when the concentration is increased above molecular overlap. The strain dependence of concentrated solutions shows a pronounced non-linearity above a critical strain, at which the storage modulus decreases suddenly, and the loss modulus exhibits a maximum. This response is similar to that observed for close-packed dispersions of soft spheres, when the applied strain is sufficient to move a sphere past its neighbors. At low and high ionic strength, the elasticity of solutions near the overlap concentration decreases. The former is interpreted as due to a decrease in intramolecular and intermolecular electrostatic repulsions, because of strong trapping of counterions within the PGA brush, the latter to salt-induced brush collapse.

  15. Concentrating on the right measures

    African Journals Online (AJOL)

    http://creativecommons.org/licenses/by-nc-nd/4.0. EDITORIAL. Concentrating on the right measures. Richard von Rahdena,b. , Zane Farinaa,b* and Michael Jamesc. aDiscipline of Anaesthesia and Critical Care, Nelson Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban,.

  16. Gravimetric determination of phospholipid concentration.

    Science.gov (United States)

    Tejera-Garcia, Roberto; Connell, Lisa; Shaw, Walter A; Kinnunen, Paavo K J

    2012-09-01

    Accurate determination of lipid concentrations is an obligatory routine in a research laboratory engaged in studies using this class of biomaterials. For phospholipids, this is frequently accomplished using the phosphate assay (Bartlett, G.R. Phosphorus Assay in Column Chromatography. J. Biol. Chem. 234, 466-468, 1959). Given the purity of the currently commercially available synthetic and isolated natural lipids, we have observed that determination of the dry weight of lipid stock solutions provides the fastest, most accurate, and generic method to assay their concentrations. The protocol described here takes advantage of the high resolution and accuracy obtained by modern weighing technology. We assayed by this technique the concentrations of a number of phosphatidylcholine samples, with different degrees of acyl chain saturation and length, and in different organic solvents. The results were compared with those from Bartlett assay, (31)P NMR, and Langmuir compression isotherms. The data obtained show that the gravimetric assay yields lipid concentrations with a resolution similar or better than obtained by the other techniques. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. Benign concentric annular macular dystrophy

    Directory of Open Access Journals (Sweden)

    Luísa Salles de Moura Mendonça

    2015-06-01

    Full Text Available The purpose of the authors is to show clinical findings of a patient with benign concentric annular macular dystrophy, which is an unusual condition, and part of the "bull’s eye" maculopathy differential diagnosis. An ophthalmologic examination with color perception, fluorescein angiography, and ocular electrophysiology was performed.

  18. Lactoferrin concentration in buffalo milk

    Directory of Open Access Journals (Sweden)

    Giuseppina Giacinti

    2013-03-01

    Full Text Available The objective of this study was to quantify lactoferrin (Lfe in buffalo milk and to examine the factors affecting milk Lfe, such as the lactation stage, daily milk yield, parity, and milk somatic cells count (SCC. Milk Lfe concentration was detected by the SDS-polyacrilamide gel electrophoresis (SDS-PAGE. The overall mean of Lfe concentration was 0.332±0.165 g/L and ranged from 0.030 to 0.813 g/L. Milk Lfe concentrations increased (P<0.01 with the increase of days in milk, but it was not affected by parity. It was estimated an increase of 0.0015 g/L daily of Lfe in milk during lactation. Milk Lfe concentration was significantly affected by SCC. The differences became significant when the levels of SCC increased up to 200.000/mL. This is the first investigation on the levels of Lfe in buffalo milk in reference to daily milk production, lactation stage, parity and SCC. Further studies are needed to clarify the relationship between Lfe and SCC in buffalo milk.

  19. Fibrinogen concentrate in bleeding patients

    DEFF Research Database (Denmark)

    Wikkelsø, Anne; Lunde, Jens; Johansen, Mathias

    2013-01-01

    Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic def...... deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety....

  20. Soil radionuclide concentrations and radiological assessment in and around a refining and petrochemical company in Warri, Niger Delta, Nigeria.

    Science.gov (United States)

    Jibiri, N N; Emelue, H U

    2008-09-01

    Radioactivity measurements have been carried out using gamma-ray spectroscopy to determine the radionuclide concentrations in soil samples in the premises of the Warri Refining and Petrochemical Company located in the Niger Delta region of Nigeria and also in communities around it. The radionuclide contents of the crude oil and petroleum additives were also similarly determined. Results indicate that on the premises used by the company, the ranges of activity concentrations of (40)K, (226)Ra and (228)Th in the soil samples were 261.3-932.3 Bq kg(-1),company premises. These values are less than the world average outdoor value of 70 microSv y(-1) given by UNSCEAR. Overall, it can be concluded that the long duration of refining activities does not seem to have affected radionuclide concentrations in the environment. Measurements also showed that the observed radiation dose rates did not vary significantly from the previously determined Warri City outdoor gamma radiation dose rates, for which the probability of occurrence of any health effects of radiation was judged low. The measurements, therefore, are interpreted to represent baseline radiometric data for future reference and research in the area.

  1. Physicochemical changes effected in activated sludge by the earthworm Eisenia foetida. [Concentration of heavy metals during sludge catabolism

    Energy Technology Data Exchange (ETDEWEB)

    Hartenstein, R. (State Univ. of New York, Syracuse); Hartenstein, F.

    1981-09-01

    Measurements were made of some physicochemical changes effected in activated sludge by the earthworm Eisenia foetida following conversion of the sludge into wormcasts. Mineralization was accelerated 1.3-fold and 2% of the minerals were assimilated. The rate at which heavy metals were concentrated during sludge catabolism was also accelerated. Castings stabilized within 2 weeks, as indexed by respirometry. Nucleic acids, which can be used as an index of microbial biomass, were present at a greater concentration in the wormcasts than in the sludge, while the phenolic content, which may potentially serve as an index of humification, was less concentrated. Other changes included a reduction in pH and an increase in oxidation-reduction potential and cation exchange capacity. The major general effect of E. foetida on the physicochemical properties of activated sludge is to convert a material which has a relatively small surface/volume ratio into numerous particles with an overall large S/V ratio, thus accelerating decomposition, mineralization, drying, and preclusion of malodor.

  2. How Concentration Shields Against Distraction.

    Science.gov (United States)

    Sörqvist, Patrik; Marsh, John E

    2015-08-01

    In this article, we outline our view of how concentration shields against distraction. We argue that higher levels of concentration make people less susceptible to distraction for two reasons. One reason is that the undesired processing of the background environment is reduced. For example, when people play a difficult video game, as opposed to an easy game, they are less likely to notice what people in the background are saying. The other reason is that the locus of attention becomes more steadfast. For example, when people are watching an entertaining episode of their favorite television series, as opposed to a less absorbing show, attention is less likely to be diverted away from the screen by a ringing telephone. The theoretical underpinnings of this perspective, and potential implications for applied settings, are addressed.

  3. Concentrating Solar Power Fact Sheet

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-12-01

    This fact sheet is an overview of the Concentrating Solar Power (CSP) subprogram at the U.S. Department of Energy SunShot Initiative. CSP is a dispatchable, renewable energy option that uses mirrors to focus and concentrate sunlight onto a receiver, from which a heat transfer fluid carries the intense thermal energy to a power block to generate electricity. CSP systems can store solar energy to be used when the sun is not shining. It will help meet the nation’s goal of making solar energy fully cost-competitive with other energy sources by the end of the decade. Worldwide, CSP activity is rapidly scaling, with approximately 10 gigawatts (GW) in various stages of operation or development. In the United States alone, nearly 2 GW of CSP are in operation.

  4. Development of concentrator solar cells

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    A limited pilot production run on PESC silicon solar cells for use at high concentrations (200 to 400 suns) is summarized. The front contact design of the cells was modified for operation without prismatic covers. The original objective of the contract was to systematically complete a process consolidation phase, in which all the, process improvements developed during the contract would be combined in a pilot production run. This pilot run was going to provide, a basis for estimating cell costs when produced at high throughput. Because of DOE funding limitations, the Photovoltaic Concentrator Initiative is on hold, and Applied Solar`s contract was operated at a low level of effort for most of 1993. The results obtained from the reduced scope pilot run showed the effects of discontinuous process optimization and characterization. However, the run provided valuable insight into the technical areas that can be optimized to achieve the original goals of the contract.

  5. Luminescent solar concentrators employing phycobilisomes

    Energy Technology Data Exchange (ETDEWEB)

    Mulder, Carlijn L.; Theogarajan, Luke; Currie, Michael; Mapel, Jonathan K.; Baldo, Marc A. [Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Vaughn, Michael; Willard, Paul; Bruce, Barry D. [Biochemistry, Cellular and Molecular Biology and Chemical and Biomolecular Engineering University of Tennessee at Knoxville 125 Austin Peay Bldg., Knoxville, TN 37996 (United States); Moss, Mark W.; McLain, Clifford E.; Morseman, John P. [Columbia Biosciences Corporation 6440 Suite D Dobbin Road, Columbia, MD 21045 (United States)

    2009-08-21

    Phycobilisome-based luminescent solar concentrators (LSCs) take advantage of the photosynthetic antenna complexes of red algae and cyanobacteria. The phycobilisomes are successfully stabilized in a solid-state LSC matrix with minimal loss of performance. Comparison of samples with intact and decoupled complexes indicates that energy transfer within intact phycobilisomes results in a reduction of re-absorption losses by {proportional_to}50%. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  6. Concentration and vertical distribution of 137Cs in the undisturbed soil of southwestern Nigeria.

    Science.gov (United States)

    Ajayi, I R; Fischer, H W; Burak, A; Qwasmeh, A; Tabot, B

    2007-01-01

    The results of measurements of 137Cs in soil profiles that were sampled in undisturbed soil in Ondo, Ekiti, and Oyo states in the southwestern area of Nigeria are presented in this paper. Samples were collected from nine soil profiles. The vertical distributions of 137Cs in the soil profiles have been determined. Cesium concentration ranged from 0.31 +/- 0.10 Bq kg(-1) in the 0-2 cm depth to a maximum of 1.25 +/- 0.21 Bq kg(-1) in the 6-8 cm depth at some sites and from 3.16 +/- 0.16 Bq kg(-1) in 0-5 cm depth to below detection limit (BDL) at 20-25 cm at another site. 137Cs total deposition in 0-10 cm depth was found to be greatest at Ikogosi site with a value of 90.30 Bq m(-2). The results generally showed that more than 40 y after the first nuclear weapon tests, 137Cs still remains within the 25 cm upper layer of soil in the region with a migration velocity of 0.17-0.18 cm y(-1). The mean value of effective dose commitment due to the presence of cesium in soil in the entire region was found to be 10.77 microSv.

  7. Increasing insolation and greenhouse gas concentration trigger Bølling-Allerød warming

    Science.gov (United States)

    Obase, Takashi; Abe-Ouchi, Ayako

    2017-04-01

    During the last deglaciation, a major global warming was punctuated by several abrupt climate changes, likely related to Atlantic Meridional Overturning Curculation (AMOC) (Clark et al. 2012). Transient deglaciation experiments from the Last Glacial Maximum have been conducted by applying time-dependent insolation, greenhouse gas concentrations, and glacial meltwater forcing (Liu et al. 2009). They have showed that reduction in glacial meltwater discharge rate into North Atlantic induces abrupt recovery of AMOC, warming of Greenland and cooling of Antarctica (bipolar response) during the period of Bølling-Allerød (BA, 14.6 ka). We conduct a transient simulation from the Last Glacial Maximum to BA using an atmosphere-ocean coupled general circulation model (AOGCM) MIROC 4m (an IPCC-class Japanese community model). The model is initialized with the 21ka, and we change insolation, greenhouse gas concentrations and meltwater fluxes following the protocol of PMIP4 (Ivanovic et al. 2016). Glacial meltwater is derived from ice sheet reconstruction (ICE6g, Peltier et al. 2015). We assume the glacial meltwater due to ice sheet loss is uniformly applied to the area of 50-70N North Atlantic Ocean. We conduct additional experiments branched from 16 ka, where 50-80% of ICE6g meltwater fluxes are applied without reducing the meltwater fluxes before the BA. The model results show that abrupt resumption of AMOC and warming of Greenland occurred at around the period of BA even under hosing of 0.06 Sv. Transition from cold stadial mode to warm interstadial mode occurs in about 100 years, which is consistent with reconstructions (Buizert et al. 2014). The result implies that increasing summer insolation and greenhouse gas concentration trigger abrupt AMOC recovery and warming in the Northern Hemisphere, and large fluctuation of meltwater due to ice sheet melting may not be necessary.

  8. Freeze concentration beats the heat

    Energy Technology Data Exchange (ETDEWEB)

    Rosen, J.

    1990-12-01

    This paper reports on freeze concentration (FC) which saves energy and money in packaging, shipping, and storing food products. FC---in contrast to existing heat-evaporation processes---retains volatile flavor and aroma compounds in food products so that no additives are required to restore the taste and smell of the original product. In recent tests on orange, grapefruit, and pineapple juices, reconstituted FC juices were found to be superior in taste to juices produced by evaporation and similar to the original pasteurized juices. The dairy industry, which is the largest user of energy for concentration in the food sector, is looking to FC for new products such as frozen concentrated milk as well as better use of the milk by-products of cheese production. The biggest potential for new FC applications is in those industries that consume large amounts of energy for separation processing, according to a 1987 report prepared for EPRI. In the food industry, this includes milk, vinegar, and beer producers. Potential applications also abound in the pulp and paper, pharmaceutical, chemical, and petroleum industries. FC separates substances via crystallization at substantial energy savings.

  9. Advanced high efficiency concentrator cells

    Energy Technology Data Exchange (ETDEWEB)

    Gale, R. (Varian Associates, Inc., Palo Alto, CA (United States). Varian Research Center)

    1992-06-01

    This report describes research to develop the technology needed to demonstrate a monolithic, multijunction, two-terminal, concentrator solar cell with a terrestrial power conversion efficiency greater than 35%. Under three previous subcontracts, Varian developed many of the aspects of a technology needed to fabricate very high efficiency concentrator cells. The current project was aimed at exploiting the new understanding of high efficiency solar cells. Key results covered in this report are as follows. (1) A 1.93-eV AlGaAs/1.42-eV GaAs metal-interconnected cascade cell was manufactured with a one-sun efficiency at 27.6% at air mass 1.5 (AM1.5) global. (2) A 1.0eV InGaAs cell was fabricated on the reverse'' side of a low-doped GaAs substrate with a one-sun efficiency of 2.5% AM1.5 diffuse and a short-circuit current of 14.4 mA/cm{sup 2}. (3) Small-scale manufacturing of GaAs p/n concentrator cells was attempted and obtained an excellent yield of high-efficiency cells. (4) Grown-in tunnel junction cell interconnects that are transparent and thermally stable using C and Si dopants were developed. 10 refs.

  10. Microcystin concentration in fishpond waters

    Directory of Open Access Journals (Sweden)

    Tokodi Nada J.

    2014-01-01

    Full Text Available Cyanobacterial blooming is a worldwide problem which sometimes results in cyanotoxin production. Most commonly produced cyanotoxins are microcystins (MCs, potent inhibitors of protein phosphatases. Protein phosphatase 1 (PP1 is known to be involved in the regulation of a variety of cellular processes. In this study, MC concentration was assessed via inhibition of protein phosphatase 1 (PP1 assay in water samples taken from 14 lakes of Mužlja fishpond, Vojvodina, Serbia. During the summer of 2011, cyanobacterial growth occured in the fishpond lakes and small, planktonic crustacean Daphnia sp. was used to control or/and prevent further development of cyanobacteria. Different MC concentrations (calculated as microcystin-LR equivalents were detected, mostly depending on the occurrence and grazing of Daphnia sp. More thorough monitoring of fishponds should be conducted, both in Serbia and around the world, in order to gain more precise estimation of cyanotoxin concentrations and their accumulation in organisms used for human consumption and thus prevent possible negative health effects. [Projekat Ministarstva nauke Republike Srbije, br.176020

  11. Photovoltaic concentrator module improvements study

    Energy Technology Data Exchange (ETDEWEB)

    Levy, S.L.; Kerschen, K.A. (Black and Veatch, Kansas City, MO (United States)); Hutchison, G. (Solar Kinetics, Inc., Dallas, TX (United States)); Nowlan, M.J. (Spire Corp., Bedford, MA (United States))

    1991-08-01

    This report presents results of a project to design and fabricate an improved photovoltaic concentrator module. Using previous work as a baseline, this study conducted analyses and testing to select major module components and design features. The lens parquet and concentrator solar cell were selected from the highest performing, available components. A single 185X point-focus module was fabricated by the project team and tested at Sandia. Major module characteristics include a 6 by 4 compression-molded acrylic lens parquet (0.737 m{sup 2} area), twenty-four 0.2 ohms-cm, FZ, p-Si solar cells (1.56 cm{sup 2} area) soldered to ceramic substrates and copper heat spreaders, and an aluminized steel housing with corrugated bottom. This project marked the first attempt to use prismatic covers on solar cells in a high-concentration, point-focus application. Cells with 15 percent metallization were obtained, but problems with the fabrication and placement of prismatic covers on these cells lead to the decision not to use covers in the prototype module. Cell assembly fabrication, module fabrication, and module optical design activities are presented here. Test results are also presented for bare cells, cell assemblies, and module. At operating conditions of 981 watts/m{sup 2} DNI and an estimated cell temperature of 65{degrees}C, the module demonstrated an efficiency of 13.9 percent prior to stressed environmental exposure. 12 refs., 56 figs., 7 tabs.

  12. Measurement of radiocesium concentration in trees using cumulative gamma radiation dose rate detection systems - A simple presumption for radiocesium concentration in living woods using glass-badge based gamma radiation dose rate detection system

    Energy Technology Data Exchange (ETDEWEB)

    Yoshihara, T.; Hashida, S.N. [Plant Molecular Biology, Laboratory of Environmental Science, Central Research Institute of Electric Power Industry (CRIEPI), 1646 Abiko, Chiba 270-1194 (Japan); Kawachi, N.; Suzui, N.; Yin, Y.G.; Fujimaki, S. [Radiotracer Imaging Gr., Quantum Beam Science Center, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Nagao, Y.; Yamaguchi, M. [Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan)

    2014-07-01

    significant difference between each settings of A, B, and C and the setting D after 15 days measurement (approx. 50 μSv). It is notable that the 15 days integrated hourly air dose rates (0.25-0.26 μSv h{sup -1}) measured with a NaI scintillator under the bough were almost equal to the cumulative dose measured with the glass-badge with the settings A and B (approx. 90 μSv). At this time, the radiocesium concentration in the bough measured with a Ge-semiconductor detector were 670-1060 Bq kg-DW{sup -1}. In other words, at least this level of radiocesium were detectable by the glass-badge under the condition. Further data are required to establish a specific correlation between the glass-badge detected cumulative dose and the specific radiocesium concentration. In addition, utilization of a recently developed semiconductor-typed cumulative dose detector and/or the improvement of the measurement procedure may advance the detection limitation/accuracy. (authors)

  13. Parabolic dish photovoltaic concentrator development

    Science.gov (United States)

    Beninga, K.; Davenport, R.; Featherby, M.; Sandubrae, J.; Walcott, K.

    1991-05-01

    Science Applications International Corporation (SAIC) and Tactical Fabs, Inc. (TFI) have fabricated a prototype parabolic dish photovoltaic (PV) concentrator system to demonstrate the functionality of this approach. A 1.5 m diameter parabolic dish was fabricated of a polyester/fiberglass composite, with a silvered polymer reflective surface. An innovative receiver cooling system used outward radial flow of cooling water in a narrow passage. This configuration matches the heat transfer capability of the cooling system to the flux profile on the PV receiver, minimizing temperature variations across the receiver. The photovoltaic cells used in the system were a new, TFI-proprietary design. Interleaved contacts form a bi-polar, rear-contact cell configuration. Because the electrical contacts are made on the rear of the cells, cells can be close-packed to form receiver arrays of arbitrary shape and size. Optical testing of the dish concentrator was performed by SAIC, SERI, and Sandia National Labs. The dish concentrator, designed for solar thermal applications, had a tight focal spot but exhibited flux non-uniformities away from the focal plane. Thermal testing of the receiver cooling system was performed with excellent success. Single PV cells, 4-cell blocks, and 144-cell receiver modules were built and tested. The cells successfully demonstrated the TFI design concept, but due to cell processing problems their efficiency was very low. Sources of the processing problems were identified and solutions were proposed, but funding limitations precluded further cell production. Operation of the complete PV dish system was conducted, and the functionality of the system was demonstrated. However, low cell efficiencies and receiver plane flux non-uniformities caused the system performance to be very low. These problems are not generic to the concept, and solutions to them proposed.

  14. Freeze concentration of lime juice

    OpenAIRE

    Ampawan Tansakul

    2008-01-01

    The main objective of this research was to study the effects of processing conditions, i.e. cooling medium temperature (-6, -12 and -18C) and scraper blade rotational speed (50, 100 and 150 rpm) on the freeze concentration of lime juice. The initial soluble solid content of lime juice was 7.6 Brix. Results showed that soluble solid content of lime juice increased as cooling medium temperature decreased while scraper blade rotational speed increased. It was also found that the processing con...

  15. Technology Roadmaps: Concentrating Solar Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The emerging technology known as concentrating solar power, or CSP, holds much promise for countries with plenty of sunshine and clear skies. Its electrical output matches well the shifting daily demand for electricity in places where airconditioning systems are spreading. When backed up by thermal storage facilities and combustible fuel, it offers utilities electricity that can be dispatched when required, enabling it to be used for base, shoulder and peak loads. Within about one to two decades, it will be able to compete with coal plants that emit high levels of CO2. The sunniest regions, such as North Africa, may be able to export surplus solar electricity to neighbouring regions, such as Europe, where demand for electricity from renewable sources is strong. In the medium-to-longer term, concentrating solar facilities can also produce hydrogen, which can be blended with natural gas, and provide low-carbon liquid fuels for transport and other end-use sectors. For CSP to claim its share of the coming energy revolution, concerted action is required over the next ten years by scientists, industry, governments, financing institutions and the public. This roadmap is intended to help drive these indispensable developments.

  16. Concentrated photovoltaics, a case study

    Directory of Open Access Journals (Sweden)

    Antonini Piergiorgio

    2014-01-01

    Full Text Available Concentrated Photovoltaics (CPV, once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  17. Monitoring particle concentrations from space

    Science.gov (United States)

    Holzer-Popp, T.; Schroedter, M.

    2003-04-01

    The potential for space-borne monitoring of concentrations of different aerosols at the ground is assessed. Generally, retrieval from satellite sensors delivers aerosol optical thickness. In order to deduce surface level mass concentration values (PM10, PM2.5, or other), two additional pieces of information must be available: (1) characterization of the type of aerosols, and (2) the vertical profile of aerosols. Several means are discussed to obtain this missing data: The type of aerosols can be estimated to some extent from multispectral satellite observations or from atmospheric models driven by meteorological analysis and surface emissions. The key feature in the vertical profile, namely the boundary layer height, can also be extracted from online atmospheric models or from additional measurements (e. g. lidar from ground or in the future from space-borne lidar). UV measurements in synergy with visible measurements from space also contain valuable information on the vertical extent of the lowest aerosol layer. Errors due to missing or inaccurate information on type and profile are estimated.

  18. Freeze concentration of lime juice

    Directory of Open Access Journals (Sweden)

    Ampawan Tansakul

    2008-11-01

    Full Text Available The main objective of this research was to study the effects of processing conditions, i.e. cooling medium temperature (-6, -12 and -18C and scraper blade rotational speed (50, 100 and 150 rpm on the freeze concentration of lime juice. The initial soluble solid content of lime juice was 7.6 Brix. Results showed that soluble solid content of lime juice increased as cooling medium temperature decreased while scraper blade rotational speed increased. It was also found that the processing condition with -18˚C cooling medium temperature and 150 rpm rotational speed of the scraper blade was the best among all studied conditions, although the loss of the soluble solids with ice crystals during ice separation was relatively high at 35%.

  19. [Concentration or decline in Puebla?].

    Science.gov (United States)

    Cabrera Becerra, V

    1993-04-01

    Some doubts have been expressed over whether the slowing pace of urbanization suggested by the 1990 census of Mexico was an accurate reflection of changing conditions, or whether it resulted from some intentional or unintended bias. Comparison of data from succeeding censuses indicates that the growth rate of the city of Puebla declined from 6.32% in 1980 to 2.63% in 1990. This work argues that, in Puebla, a trend to deconcentration of the population within the city of Puebla during the 1980s was accompanied by rapid growth in smaller and medium sized nearby cities, resulting in increased overall concentration in Puebla's metropolitan area. The absolute population of the city of Puebla increased from 772,908 in 1980 to 1,007,170 in 1990. The central area of the state of Puebla, which surrounds the city, increased its share of the state population from 51.67% in 1980 to 52.21% in 1990. The number of places with over 5000 inhabitants in the area surrounding the city of Puebla increased from 27 in 1980 to 39 in 1990. Construction of the Puebla-Atlixco highway will undoubtedly attract growth to the area southwest of Puebla. Small cities to the east of Puebla have shown significant growth although their region remains strongly rural. The same process of deconcentration of population in Puebla and concentration in its surrounding metropolitan regions can probably also be detected in patterns of investment of public funds. The trend is likely to continue through the 1990s.

  20. Cerebrospinal fluid concentration of fibronectin in meningitis.

    OpenAIRE

    Torre, D; Zeroli, C; Issi, M; Fiori, G P; Ferraro, G.; Speranza, F

    1991-01-01

    Fibronectin concentrations in the cerebrospinal fluid were assessed in 20 patients with acute meningitis using a turbidimetric immunoassay. A significant increase in fibronectin concentrations was observed in patients with bacterial meningitis; decreased concentrations were observed in patients with viral meningitis. The determination of fibronectin concentration in patients with bacterial meningitis may represent a useful marker in differentiating bacterial from viral meningitis.

  1. The concentration of retail in Poland

    Directory of Open Access Journals (Sweden)

    Michał Gazdecki

    2010-01-01

    Full Text Available The article discusses the processes of concentration taking place in retail in Poland. In spite of strong concentration processes, which took place after 2000, Poland still remains a country of dispersed retail structure. In the nearest years we can expect capital concentration (mainly takeovers in modern trade and contract concentration (for example, merchants’ societies in traditional trade.

  2. 49 CFR 382.201 - Alcohol concentration.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Alcohol concentration. 382.201 Section 382.201... ALCOHOL USE AND TESTING Prohibitions § 382.201 Alcohol concentration. No driver shall report for duty or... concentration of 0.04 or greater. No employer having actual knowledge that a driver has an alcohol concentration...

  3. Radon concentration in drinking water and supplementary exposure in Baita-Stei mining area, Bihor county (Romania).

    Science.gov (United States)

    Moldovan, Mircea; Nita, Dan Constantin; Cucos-Dinu, Alexandra; Dicu, Tiberius; Bican-Brisan, Nicoleta; Cosma, Constantin

    2014-03-01

    The radon concentration was measured in the drinking water of public water supply and private wells located in the mining area of BăiŢa-Ştei, Bihor County, Romania. The measurements were performed using the LUK-VR system based on radon gas measurement with Lucas cell. The results show that the radon concentrations are within the range of 1.9-134.3 kBq m(-3) with an average value of 35.5 kBq m(-3) for well water, 18.5 kBq m(-3) for spring water and 6.9 kBq m(-3) for tap water. Comparing with previous data from the whole of Transylvania, the average value is two times higher, proving this zone to be a radon-prone area. From the results of this study the effective dose to the population is between 4.78 and 338.43 µSv y(-1). These doses are within the recommended limits of the world organisations.

  4. Radiocesium concentrations in wild mushrooms collected in Kawauchi Village after the accident at the Fukushima Daiichi Nuclear Power Plant

    Directory of Open Access Journals (Sweden)

    Kanami Nakashima

    2015-11-01

    Full Text Available It is well known from the experience after the 1986 accident at the Chernobyl Nuclear Power Plant that radiocesium tends to concentrate in wild mushrooms. In this study, we collected wild mushrooms from the Kawauchi Village of Fukushima Prefecture, located within 30 km of the Fukushima Daiichi Nuclear Power Plant, and evaluated their radiocesium concentrations to estimate the risk of internal radiation exposure in local residents. We found that radioactive cesium exceeding 100 Bq/kg was detected in 125 of 154 mushrooms (81.2%. We calculated committed effective doses based on 6,278 g per year (age > 20 years, 17.2 g/day, the average intake of Japanese citizens, ranging from doses of 0.11–1.60 mSv, respectively. Although committed effective doses are limited even if residents eat contaminated foods several times, we believe that comprehensive risk-communication based on the results of the radiocesium measurements of food, water, and soil is necessary for the recovery of Fukushima after this nuclear disaster.

  5. Activities concentration of radiocesium in wild mushroom collected in Ukraine 30 years after the Chernobyl power plant accident

    Directory of Open Access Journals (Sweden)

    Makiko Orita

    2018-01-01

    Full Text Available Mushrooms are recognized as one of the main contributors to internal radiation exposure from the activity concentration of radiocesium released by the accident at the Chernobyl nuclear power plant (CNNP. We evaluated the activity concentrations of the artificial radionuclides (radiocesium in wild mushrooms collected in 2015 from Korosten and Lugine, Zhitomir region, Ukraine, located 120 km away from the CNPP. Cesium-137 was detected in 110 of 127 mushroom samples (86.6%. Based on the average mushroom consumption (5 kg per year, we calculated committed effective doses ranging from 0.001–0.12 mSv. Cesium-137 remains in the wild mushrooms even 30 years after the accident, but the committed effective doses are limited by the amount of contaminated mushrooms consumed. However, evaluation of internal radiation exposure and assessment of environmental radioactivity in the surrounding area affected by the nuclear accident are still necessary in order to relieve anxiety about internal radiation exposure, as long as the possibility of consumption of contaminated mushrooms remains.

  6. Measurements of radon gas concentrations in dwellings of Al-Madinah Al-Munawarah province in Saudi Arabia.

    Science.gov (United States)

    Mohamed, R I; Alfull, Z Z; Dawood, N D

    2014-01-01

    Indoor radon concentration levels in a large number of dwellings in Al-Madinah Al-Munawarah Province have been measured. Al-Madinah Al-Munawarah is in the western region of Saudi Arabia. It is the second holiest city in Islam after Mecca, because it is the burial place of the Islamic Prophet Muhammad. The city was divided into four regions: western (contains nine sites), eastern (contains six sites), northern (contains nine sites) and southern (contains five sites). Radon gas concentration was measured using the closed chamber technique employing 2×2 cm(2) sheets of CR-39 solid-state nuclear track detectors. The detectors were kept for a period of 5 to 6 months from September 2010 to February 2011 in order to expose to radon gas. The results of the survey in the western and eastern sites showed that the overall minimum, maximum and average radon concentration levels were 20±1.6, 27±3.2 and 21±2.5 Bq m(-3), respectively. The lowest average radon concentration (20±1.6 Bq m(-3)) was found in Al Anabes and Al Suqya in the western region and Bani Dhafar in the eastern region, while the highest average concentration (27±3.2 Bq m(-3)) was found in Teeyba in the western region and Al 'Aridh in the eastern region, with an average of 21±2.5 Bq m(-3) in the western and eastern sites of Al-Madinah Al-Munawarah. Also in the northern region, the minimum radon concentration was 20±1.6 Bq m(-3) in Oyun, while the maximum was 42±1.6 Bq m(-3) in Sayyed al Shuhadd and Hai Nasr. In the southern region, the minimum radon concentration was 25±2.6 Bq m(-3) at Hai Al Hejrah, while the maximum value was 37±2.6 Bq m(-3) at Al Awali and Dawadia. The average radon concentration was 26±2.5 Bq m(-3) for Al-Madinah Al-Munawarah (western, eastern, northern and southern regions). The corresponding annual effective dose E (mSv y(-1)) to public from (222)Rn and its progeny was estimated to be 0.66 mSv y(-1) as an average value for Al-Madinah Al-Munawarah. The authors concluded that all

  7. Estimated doses related to {sup 222}Rn concentration in bunker for radiotherapy and storage of radioisotopes; Dosis estimada por concentraciones de {sup 222}Rn en bunker de radioterapia y de almacenamiento de isotopos radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Mestre, Freddy; Carrizales-Silva, Lila, E-mail: freddymest@gmail.com, E-mail: lcarriza@ivic.gob.ve [Instituto Venezolano de lnvestigaciones Cientificas, Caracas (Venezuela, Bolivarian Republic of); Sajo-Bohus, Laszlo, E-mail: sajobohus@gmail.com [Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Laboratorio de Fisica Nuclear; Diaz, Cruz, E-mail: cruzediaZ@gmail.com [Universidad Pedagogica Experimental Libertador, Barquisimeto (Venezuela, Bolivarian Republic of). Instituto Pedagogico

    2013-07-01

    It was done a survey in radiotherapy services underground hospitals and clinics of Venezuela and Paraguay in order to estimate the concentrations of radon and its possible consequences on worker occupational exposure. Passive dosimeters were used to assess nuclear traces (NTD type CR-39 Registered-Sign ). The concentration of {sup 222}Rn is determined based on the density of traces using the calibration coefficient of 1 tr/cm{sup 2} equivalent to 0,434 Bqm{sup -3} per month of exposure. Assuming the most likely environmental conditions and the dose conversion factor equal to 9.0 x 10{sup -6} mSv h {sup -1} by Bqm{sup -3}, it was determined the average values and estimated the possible risks to health that are on average 3.0 mSva{sup -1} and 150 micro risk cancer.

  8. Concentrators Enhance Solar Power Systems

    Science.gov (United States)

    2013-01-01

    "Right now, solar electric propulsion is being looked at very seriously," says Michael Piszczor, chief of the photovoltaic and power technologies branch at Glen Research Center. The reason, he explains, originates with a unique NASA mission from the late 1990s. In 1998, the Deep Space 1 spacecraft launched from Kennedy Space Center to test a dozen different space technologies, including SCARLET, or the Solar Concentrator Array with Refractive Linear Element Technology. As a solar array that focused sunlight on a smaller solar cell to generate electric power, SCARLET not only powered Deep Space 1 s instruments but also powered its ion engine, which propelled the spacecraft throughout its journey. Deep Space 1 was the first spacecraft powered by a refractive concentrator design like SCARLET, and also utilized multi-junction solar cells, or cells made of multiple layers of different materials. For the duration of its 38-month mission, SCARLET performed flawlessly, even as Deep Space 1 flew by Comet Borrelly and Asteroid Braille. "Everyone remembers the ion engine on Deep Space 1, but they tend to forget that the SCARLET array powered it," says Piszczor. "Not only did both technologies work as designed, but the synergy between the two, solar power and propulsion together, is really the important aspect of this technology demonstration mission. It was the first successful use of solar electric propulsion for primary propulsion." More than a decade later, NASA is keenly interested in using solar electric propulsion (SEP) for future space missions. A key issue is cost, and SEP has the potential to substantially reduce cost compared to conventional chemical propulsion technology. "SEP allows you to use spacecraft that are smaller, lighter, and less costly," says Piszczor. "Even though it might take longer to get somewhere using SEP, if you are willing to trade time for cost and smaller vehicles, it s a good trade." Potentially, SEP could be used on future science missions

  9. Concentrating Solar Power. Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-10-15

    Concentrating solar power can contribute significantly to the world's energy supply. As shown in this roadmap, this decade is a critical window of opportunity during which CSP could become a competitive source of electrical power to meet peak and intermediate loads in the sunniest parts of the world. This roadmap identifies technology, economy and policy goals and milestones needed to support the development and deployment of CSP, as well as ongoing advanced research in CSF. It also sets out the need for governments to implement strong, balanced policies that favour rapid technological progress, cost reductions and expanded industrial manufacturing of CSP equipment to enable mass deployment. Importantly, this roadmap also establishes a foundation for greater international collaboration. The overall aim of this roadmap is to identify actions required - on the part of all stakeholders - to accelerate CSP deployment globally. Many countries, particularly in emerging regions, are only just beginning to develop CSP. Accordingly, milestone dates should be considered as indicative of urgency, rather than as absolutes. This roadmap is a work in progress. As global CSP efforts advance and an increasing number of CSP applications are developed, new data will provide the basis for updated analysis. The IEA will continue to track the evolution of CSP technology and its impacts on markets, the power sector and regulatory environments, and will update its analysis and set additional tasks and milestones as new learning comes to light.

  10. A STUDY ON INFORMAL MARKET CLUSTER ACTIVITIES CONCENTRATING AROUND MENDI MARKET AREA: IS RELOCATION THE BEST OPTION?

    Directory of Open Access Journals (Sweden)

    Undiri Kima

    2015-02-01

    Full Text Available The market provides a means of survival for the local and urban communities. The local farmers, local artisans, and other informal sectors find the market as their source of income and food and a place of relaxation. They find the market as a place where they meet friends. The article seeks to understand and analyze how informal sectors cluster groups agglomerate in and around the Mendi Local Market (LM area of Papua New Guinea. This research has made particular reference to Street Vendors (SV who are operating their daily activities in and along the market corridor and exert their influences to the LM and the public. The study provides the scenario to understand the impact of the social relations of the informal street vendors and their daily associated influences on LM. This article seeks to trace and to understand how informal market clusters are operating and concentrating around the local market. The conclusion suggests that the relationships of the informal sector, street vendors, and local market should be promoted through an appropriate inclusive policy and regulatory environment.The market provides a means of survival for the local and urban communities. The local farmers, local artisans, and other informal sectors find the market as their source of income and food and a place of relaxation. They find the market as a place where they meet friends. The article seeks to understand and analyze how informal sectors cluster groups agglomerate in and around the Mendi Local Market (LM area of Papua New Guinea. This research has made particular reference to Street Vendors (SV who are operating their daily activities in and along the market corridor and exert their influences to the LM and the public. The study provides the scenario to understand the impact of the social relations of the informal street vendors and their daily associated influences on LM. This article seeks to trace and to understand how informal market clusters are operating

  11. Activity concentrations of 224Ra, 226Ra, 228Ra and 40K radionuclides in refinery products and the additional radiation dose originated from oil residues in Turkey.

    Science.gov (United States)

    Parmaksiz, A; Agus, Y; Bulgurlu, F; Bulur, E; Yildiz, Ç; Öncü, T

    2013-10-01

    A total of 56 crude oil, refinery product, waste water, sludge and scale samples collected from three refineries were measured by gamma-ray spectrometry. Except for nine samples, all refinery product samples were found to have activity concentrations below the minimum detectable activity (MDA) values. The maximum (224)Ra, (226)Ra, (228)Ra and (40)K activity concentrations in crude oil and refinery product samples were measured as 11.7 ± 4.5, 14.9 ± 3.5, 11.6 ± 4.5, 248.5 ± 18.5 Bq kg(-1), respectively. The maximum (224)Ra, (226)Ra, (228)Ra and (40)K activity concentrations in scale, sludge and water samples were measured as 343.7 ± 11.8, 809.2 ± 29.0, 302.5 ± 21.6, 623.0 ± 80.9 Bq kg(-1), respectively. Radium equivalent activities of the residue samples were calculated up to 1241.8 ± 42.4 Bq kg(-1). The maximum activity concentration index and the alpha index were found to be 4.2 and 4.0, respectively. The annual effective doses of residue samples were calculated below the permitted dose rate for the public, i.e. 1 mSv y(-1).

  12. Low tube voltage computed tomography urography using low-concentration contrast media: Comparison of image quality in conventional computed tomography urography.

    Science.gov (United States)

    Hwang, Inpyeong; Cho, Jeong Yeon; Kim, Sang Youn; Oh, Seung-June; Ku, Ja Hyeon; Lee, Joongyup; Kim, Seung Hyup

    2015-12-01

    The aim of the present study was to investigate the feasibility and image quality of excretory CT urography performed using low iodine-concentration contrast media and low tube voltage. This prospective study enrolled 63 patients who undergoing CT urography. The subjects were randomized into two groups of an excretory phase CT urography protocol and received either 240 mg I/mL of contrast media and 80 kVp of tube voltage (low-concentration protocol, n=32) or 350 mg I/mL and 120 kVp (conventional protocol, n=31). Two readers qualitatively evaluated images for sharpness of the urinary tract, image noise, streak artifact and overall diagnostic acceptability. The mean attenuation, signal-to-noise ratio, contrast-to-noise ratio and figure of merit were measured in the urinary tract. The non-inferiority test assessed the diagnostic acceptability between the two protocol groups. The low-concentration protocol showed a significantly lower effective radiation dose (3.44 vs. 5.70 mSv, Pcontrast-to-noise ratio and figure of merit were significantly higher in the low-concentration protocol along the entire urinary tract (Pcontrast media, 80 kVp tube voltage and an iterative reconstruction algorithm is beneficial to reduce radiation dose and iodine load, and its objective image quality and subjective diagnostic acceptability is not inferior to that of conventional CT urography. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. Summary of Dissolved Concentration Limits

    Energy Technology Data Exchange (ETDEWEB)

    Yueting Chen

    2001-06-11

    According to the Technical Work Plan titled Technical Work Plan for Waste Form Degradation Process Model Report for SR (CRWMS M&O 2000a), the purpose of this study is to perform abstractions on solubility limits of radioactive elements based on the process-level information and thermodynamic databases provided by Natural Environment Program Operations (NEPO) and Waste Package Operations (WPO). The scope of this analysis is to produce solubility limits as functions, distributions, or constants for all transported radioactive elements identified by the Performance Assessment Operations (PAO) radioisotope screening. Results from an expert elicitation for solubility limits of most radioactive elements were used in the previous Total System Performance Assessments (TSPAs). However, the elicitation conducted in 1993 does not meet the criteria set forth by the U.S. Nuclear Regulatory Commission (NRC) due to lack of documentation and traceability (Kotra et al. 1996, Section 3). Therefore, at the Waste Form Abstraction Workshop held on February 2-4, 1999, at Albuquerque, New Mexico, the Yucca Mountain Site Characterization Project (YMP) decided to develop geochemical models to study solubility for the proposed Monitored Geologic Repository. WPO/NEPO is to develop process-level solubility models, including review and compilation of relevant thermodynamic data. PAO's responsibility is to perform abstractions based on the process models and chemical conditions and to produce solubility distributions or response surfaces applicable to the proposed repository. The results of this analysis and conceptual model will feed the performance assessment for Total System Performance Assessment--Site Recommendation (TSPA-SR) and Total System Performance Assessment--License Application (TSPA-LA), and to the Waste Form Degradation Process Model Report section on concentration limits.

  14. Effective dose and concentration of radon and thoron gases at hospitals of Kermanshah University of Medical Sciences (2012

    Directory of Open Access Journals (Sweden)

    Meghdad Pirsaheb

    2014-09-01

    Full Text Available Background: Considering the health care importance of indoor radon, especially in the case of lung cancer, this study was aimed to evaluate indoor radon and thoron levels in three hospitals of Kermanshah city with high recourse. Methods: Measurements of indoor radon and thoron levels in Imam Reza, Imam Khomaini and Taleghani hospital buildings in Kermanshah city in different parts, including ICU, inpatient wards, operating rooms and offices were done using RTM 1688-2 radon meter. Measurements were performed in three months of fall season in 2012 (once per month, and totally 102 measurements were done. The annual effective dose was assessed using the equation for annual effective dose calculation introduced by United Nations Scientific Committee on the Effects of Atomic Radiation. Results: Average indoor radon and thoron levels were 11.44±4.9 Bq/m3 and 4±3.9 Bq/m3, respectively. Maximum radon concentration was measured in Imam Raza hospital (13.7±4.3 Bq/m3 and minimum radon concentration was observed in Imam khomaini hospital (6.8±4.4 Bq/m3. The average annual effective dose due to radon and thoron was estimated to be 0.13 mSv/y. Conclusion: Based on the results, radon and thoron levels and their average effective dose in all hospital buildings were below the proposed limits. The concentrations of radon and thoron were influenced by natural and artificial ventilation of the rooms and building materials used for walls and floors. Radon and thoron concentration level was reported high in ICU.

  15. 2011 NATA - Risks and Annual Ambient Concentrations

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset includes the modeled annual ambient concentrations and risks at the census tract level for the 2011 National Air Toxics Assessment. All concentrations...

  16. Basic investigation of concentrator using fluorescent substance

    Energy Technology Data Exchange (ETDEWEB)

    Hayashibara, Mitsuo

    1986-12-01

    A concentrator was manufactured on an experimental basis to improve the performance of the concentrator using fluorescent substance and the analysis based on the test result of optical characteristics of the materials composing the concentrator was made. The concentrator is composed of fluorescent substance sandwiched between two acrylic sheets. Organic fluorescent solution prepared by dissolving eosin to alcohol and capsulating with transparent encapsulant was used as the fluorescent substance. The concentration ratio based on the characteristic tests of the fluorescent substance and material of acrylic sheet composing the concentrator and the numerical calculation model was calculated. The results show that the difference between the experimental and calculated values is 10%. The result of calculation based on the numerical model indicates that the energy efficiency is decreased through the concentration ratio is increased in a thin concentrator, because the fluorescence is decreased by the absorption during passing more frequently through the fluorescent layer. (1 ref, 10 figs)

  17. Know Concentration Before Giving Acetaminophen to Infants

    Science.gov (United States)

    ... For Consumers Home For Consumers Consumer Updates Know Concentration Before Giving Acetaminophen to Infants Share Tweet Linkedin ... infants has only been available in a stronger concentration that doesn’t require giving the infants as ...

  18. Medical Oxygen Concentrator for Microgravity Operation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We have all seen people carrying portable oxygen tanks or concentrators to provide critical life support respiratory oxygen. Heavy, bulky, and for O2 concentrators,...

  19. Concentration in the mobile operating systems market

    OpenAIRE

    Naldi, Maurizio

    2016-01-01

    Concentration phenomena concern the ICT market. Though the regulatory action has been active mainly in the telecom network operators industry, even more significant worldwide concentration phenomena affect other industries. The market of mobile operating systems is analysed through two concentration indices to get a quantitative picture of the current situation and its evolution over time: the Hirschman Herfindahl Index (HHI) and the Four-Firm Concentration Ratio (CR4). A strongly imbalanced ...

  20. 75 FR 23764 - Correspondent Concentration Risks

    Science.gov (United States)

    2010-05-04

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Correspondent Concentration Risks AGENCY: Federal..., Board, OCC, and OTS (the Agencies) are issuing final guidance on Correspondent Concentration Risks (CCR..., monitor, and manage credit and funding concentrations to other institutions on a standalone and...

  1. 49 CFR 199.215 - Alcohol concentration.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Alcohol concentration. 199.215 Section 199.215... Prevention Program § 199.215 Alcohol concentration. Each operator shall prohibit a covered employee from... alcohol concentration of 0.04 or greater. No operator having actual knowledge that a covered employee has...

  2. 40 CFR 264.94 - Concentration limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Concentration limits. 264.94 Section... From Solid Waste Management Units § 264.94 Concentration limits. (a) The Regional Administrator will specify in the facility permit concentration limits in the ground water for hazardous constituents...

  3. Spectrophotometric methods to determine protein concentration.

    Science.gov (United States)

    Goldring, J P Dean

    2015-01-01

    Measuring the concentration of proteins is an essential part of enzyme evaluations or to monitor protein yields during protein isolation procedures. Decisions on the usefulness of any isolation procedure depend on knowing the relative concentrations of a particular protein or enzyme in relation to the concentrations of all the proteins present. Protein concentration in solution is generally measured with spectrophotometry in the UV range or in the presence of dyes or copper interacting with the protein. This review describes protein determination methods for measuring protein concentration in solution.

  4. Dense-array concentrator photovoltaic system using non-imaging dish concentrator and crossed compound parabolic concentrator

    Science.gov (United States)

    Chong, Kok-Keong; Yew, Tiong-Keat; Wong, Chee-Woon; Tan, Ming-Hui; Tan, Woei-Chong; Lai, An-Chow; Lim, Boon-Han; Lau, Sing-Liong; Rahman, Faidz Abdul

    2015-04-01

    Solar concentrating device plays an important role by making use of optical technology in the design, which can be either reflector or lens to deliver high flux of sunlight onto the Concentrator Photovoltaic (CPV) module receiver ranging from hundreds to thousand suns. To be more competitive compared with fossil fuel, the current CPV systems using Fresnel lens and Parabolic dish as solar concentrator that are widely deployed in United States, Australia and Europe are facing great challenge to produce uniformly focused sunlight on the solar cells as to reduce the cost of electrical power generation. The concept of non-imaging optics is not new, but it has not fully explored by the researchers over the world especially in solving the problem of high concentration solar energy, which application is only limited to be a secondary focusing device or low concentration device using Compound Parabolic Concentrator. With the current advancement in the computer processing power, we has successfully invented the non-imaging dish concentrator (NIDC) using numerical simulation method to replace the current parabolic dish as primary focusing device with high solar concentration ratio (more than 400 suns) and large collective area (from 25 to 125 m2). In this paper, we disclose our research and development on dense array CPV system based on non-imaging optics. The geometry of the NIDC is determined using a special computational method. In addition, an array of secondary concentrators, namely crossed compound parabolic concentrators, is also proposed to further focus the concentrated sunlight by the NIDC onto active area of solar cells of the concentrator photovoltaic receiver. The invention maximizes the absorption of concentrated sunlight for the electric power generation system.

  5. Heavy Metal Concentrations in Maltese Potable Water

    Directory of Open Access Journals (Sweden)

    Roberta Bugeja

    2015-05-01

    Full Text Available This study evaluates the levels of aluminum (Al, cadmium (Cd, chromium (Cr, copper (Cu, iron (Fe, lead (Pb, nickel (Ni and zinc (Zn in tap water samples of forty localities from around the Maltese Islands together with their corresponding service supply reservoirs. The heavy metal concentrations obtained indicated that concentrations of the elements were generally below the maximum allowed concentration established by the Maltese legislation. In terms of the Maltese and EU water quality regulations, 17.5% of the localities sampled yielded water that failed the acceptance criteria for a single metal in drinking water. Higher concentrations of some metals were observed in samples obtained at the end of the distribution network, when compared to the concentrations at the source. The observed changes in metal concentrations between the localities’ samples and the corresponding supply reservoirs were significant. The higher metal concentrations obtained in the samples from the localities can be attributed to leaching in the distribution network.

  6. Chemical weathering of a marine terrace chronosequence, Santa Cruz, California I: Interpreting rates and controls based on soil concentration-depth profiles

    Science.gov (United States)

    White, A.F.; Schulz, M.S.; Vivit, D.V.; Blum, A.E.; Stonestrom, D.A.; Anderson, S.P.

    2008-01-01

    reaction kinetics. The steady-state weathering rate under such conditions is defined asR = fenced(qh ?? frac(msol, Mtotal)) ?? fenced(frac(1, Sv ?? bs)) ??. The product of qh and the ratio of solubilized to solid state feldspar (msat/Mtotal) define the weathering velocity. The weathering gradient bs reflects the kinetic rate of reaction where Sv is the volumetric surface area of the residual feldspar. Both this rate expression and the spreadsheet calculations produce similar plagioclase weathering rates (R = 5-14 ?? 10-16 mol m-2 s-1) which agree with those reported for other environments of comparable climate and age. Weathering-dependent concentration profiles are commonly described in literature. The present paper provides methods by which these data can yield a more fundamental understanding of the weathering processes involved.

  7. Radioactivity level and toxic elemental concentration in groundwater at Dei-Dei and Kubwa areas of Abuja, north-central Nigeria

    Science.gov (United States)

    Maxwell, O.; Wagiran, H.; Lee, S. K.; Embong, Z.; Ugwuoke, P. E.

    2015-02-01

    The activity concentrations of uranium and toxic elements in Dei-Dei borehole, Kubwa borehole, Water Board and hand-dug well water samples in Abuja area were measured using inductively coupled plasma mass spectrometry (ICP-MS) system. The results obtained were used to calculate human radiological risk over lifetime consumption by the inhabitants in the area. The activity concentrations of 238U in all the water supplies for drinking ranges from 0.849 mBq L-1 to 2.699 mBq L-1 with the highest value of 2.699 mBq L-1 noted at Dei-Dei borehole whereas the lowest value of 0.849 mBq L-1 was noted in Kubwa borehole. The highest annual effective dose from natural 238U in all the water samples was found in Dei-Dei borehole with a value of 8.9×10-5 mSv y-1 whereas the lowest value was noted in Kubwa borehole with a value of 2.8×10-5 mSv y-1. The radiological risks for cancer mortality were found distinctly low, with the highest value of 1.01×10-7 reported at Dei-Dei borehole compared to Kubwa borehole with a value of 3.01×10-8. The cancer morbidity risk was noted higher in Dei-Dei borehole with a value of 1.55×10-7 whereas lower value of 4.88×10-9 was reported in Kubwa borehole. The chemical toxicity risk of 238U in drinking water over a lifetime consumption has a value of 0.006 μg kg-1 day-1 in Dei-Dei borehole whereas lower value of 0.002 μg kg-1 day-1 was found in Kubwa borehole. Measured lead (Pb) and chromium (Cr) concentrations reported higher in Water Board compared to Dei-Dei and Kubwa borehole samples. Significantly, this study inferred that the 238U concentrations originate from granitic strata of the tectonic events in the area; thus, there was a trend of diffusion towards north to south and re-deposition towards Dei-Dei area.

  8. Concentration of medically used radionuclides in activated sludge at the megalopolis waste water treatment plants and estimation for the effective dose

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Takashi; Okano, Yasuhiro; Sugiura, Shiroharu; Inokoshi, Yukio [Tokyo Metropolitan Industrial Technology Research Inst. (Japan)

    1998-06-01

    The concentrations of medically used radionuclides in activated sludge samples were measured for 10 waste water treatment plants (WWTP) in Tokyo from October 1983 to March 1994. The nuclides {sup 99m}Tc, {sup 67}Ga, {sup 111}In, {sup 123}I, {sup 131}I and {sup 201}Tl, among others, could be detected, but these concentration levels were lower than the legal concentration limits in Japan. The excess activated sludge is usually incinerated at WWTP; then the resulting ash is transported for reclamation in Tokyo Bay. Internal and/or external exposure doses were evaluated for the following cases: The dose of the public attributed to radioactive iodine and {sup 201}Tl, which were released from the incinerator by burning sludge; The dose of the workers during the process of transport and reclamation of the ash. As a result, the effective doses were sufficiently lower than the dose limit 1 mSv/y. The decay of the radionuclides were calculated over a period of curing of the landfill. It was found that the radionuclides had decayed out to approximately one nuclide. The effective dose of the public can therefore be ignored. Moreover, it was clarified that the effective dose of the public resulting from {sup 99m}Tc is negligibly low in value at the present time. (author)

  9. Retention of Ascorbic Acid and Solid Concentration via Centrifugal Freeze Concentration of Orange Juice

    Directory of Open Access Journals (Sweden)

    P. Orellana-Palma

    2017-01-01

    Full Text Available Freeze concentration of liquid foods produces high-quality concentrates while retaining the heat-labile compounds found in fresh samples. Centrifugal freeze concentration is a cryoconcentration method assisted by an external force, centrifugation, to enhance the separation of concentrate from the ice. When applying centrifugal freeze concentration to orange juice, after the third cryoconcentration cycle, the ascorbic acid content in the concentrate showed retention close to 70% of the initial value. After the third cycle, the solutes in the concentrate increased 4 times the initial value of the fresh sample with 70% efficiency. The color evaluation showed that the final concentrated fraction was darker than the fresh juice. The centrifugal freeze concentration in orange juice was effective for obtaining a high-quality concentrate with a higher concentration of solids and ascorbic acid retention.

  10. Attached, unattached fraction of progeny concentrations and equilibrium factor for dose assessments from {sup 222}Rn and {sup 220}Rn

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Parminder; Saini, Komal; Bajwa, Bikramjit Singh [Guru Nanak Dev University, Department of Physics, Amritsar, Punjab (India); Mishra, Rosaline; Sahoo, Bijay Kumar [Bhabha Atomic Research Centre, Radiological Physics and Advisory Division, Mumbai (India)

    2016-08-15

    In this study, measurements of indoor radon ({sup 222}Rn), thoron ({sup 220}Rn) and their equilibrium equivalent concentration (EEC) were carried out in 96 dwellings from 22 different villages situated in Hamirpur district, Himachal Pradesh, India, by using LR-115 type II-based pinhole twin cup dosimeters and deposition-based progeny sensors (DRPS/DTPS). The annual average indoor {sup 222}Rn and {sup 220}Rn concentrations observed in these dwellings were 63.82 and 89.59 Bq/m{sup 3}, respectively, while the average EEC (attached + unattached) for {sup 222}Rn and {sup 220}Rn was 29.28 and 2.74 Bq/m{sup 3}. For {sup 222}Rn (f{sub Rn}) and {sup 220}Rn (f{sub Tn}), the average values of unattached fraction were 0.11 and 0.09, respectively. The equilibrium factors for radon (F{sub Rn}) and thoron (F{sub Tn}) varied from 0.12 to 0.77 with an average of 0.50, and from 0.01 to 0.34 with an average of 0.05, respectively. The annual inhalation dose due to mouth and nasal breathing was calculated using dose conversion factors and unattached fractions. The indoor annual effective doses for {sup 222}Rn (AEDR) and {sup 220}Rn (AEDT) were found to be 1.92 and 0.83 mSv a{sup -1}, respectively. The values of {sup 222}Rn/{sup 220}Rn concentrations and annual effective doses obtained in the present study are within the safe limits as recommended by the International Commission on Radiological Protection for indoor dwelling exposure conditions. (orig.)

  11. Uniform sunlight concentration reflectors for photovoltaic cells.

    Science.gov (United States)

    Rabady, Rabi Ibrahim

    2014-03-20

    Sunlight concentration is essential to reach high temperatures of a working fluid in solar-thermal applications and to reduce the cost of photovoltaic (PV) electricity generation systems. Commonly, sunlight concentration is realized by parabolic or cylindrical reflectors, which do not provide uniform concentration on the receiver finite surface. Uniform concentration of sunlight is favored especially for the PV conversion applications since it not only enhances the conversion efficiency of sunlight but also reduces the thermal variations along the receiving PV cell, which can be a performance and life-span limiting factor. In this paper a reflector profile that uniformly infiltrates the concentrated sunlight into the receiving unit is attempted. The new design accounts for all factors that contribute to the nonuniform concentration, like the reflector curvature, which spatially reflects the sunlight nonuniformly, and the angular dependency of both the reflector reflectivity and the sunlight transmission through the PV cell.

  12. Acceptability of oxygen concentrators: the patient's view.

    Science.gov (United States)

    Dilworth, J P; Higgs, C M; Jones, P A; White, R J

    1990-10-01

    The impact of the installation of an oxygen concentrator on the lifestyle of 30 patients in two health districts has been investigated using a questionnaire. Marked improvements in general well-being (83% of respondents), breathing (82%), mobility (62%) and sleep pattern (52%) were reported. The long term nature of the aims of treatment were understood by 83% of the respondents and the mean period of time the patients used the concentrator was satisfactory. However, 34% of respondents had a concentrator with only one outlet and 70% had the concentrator situated in a commonly used room with the possibility of problems with noise. Thirty one percent of the respondents were still smoking. The recommendations given to patients for the sitting of the concentrator and the number of outlets should be improved. However, the oxygen concentrator was found to be generally well tolerated and this refutes criticism that patients may find it restricting.

  13. Imaging Extracellular Protein Concentration with Nanoplasmonic Sensors

    OpenAIRE

    Byers, Jeff M.; Christodoulides, Joseph A.; Delehanty, James B.; Raghu, Deepa; Raphael, Marc P.

    2015-01-01

    Extracellular protein concentrations and gradients queue a wide range of cellular responses, such as cell motility and division. Spatio-temporal quantification of these concentrations as produced by cells has proven challenging. As a result, artificial gradients must be introduced to the cell culture to correlate signal and response. Here we demonstrate a label-free nanoplasmonic imaging technique that can directly map protein concentrations as secreted by single cells in real time and which ...

  14. [Plasma ionized magnesium concentration following cardiopulmonary bypass].

    Science.gov (United States)

    Amaya, Fumimasa; Fukui, Michihiko; Tsuruta, Hiroshi; Kooguchi, Kunihiko; Shimosato, Goshun

    2002-06-01

    We performed a retrospective study to analyze plasma ionized magnesium concentration following cardiopulmonary bypass. Severe decrease of ionized magnesium concentration associated with frequent abnormal ECG sign was found in a patient with magnesium-free cardioplegia. Cardioplegia containing 16 mmol.l-1 of magnesium ion maintained ionized magnesium concentration within normal ranges without postoperative magnesium loading. Use of cardioplegia containing magnesium or adequate magnesium supplement is thought to be essential for patients receiving cardiopulmonary bypass.

  15. Bank Concentration and Fragility: Impact and Mechanics

    OpenAIRE

    Thorsten Beck; Asli Demirguc-Kunt; Ross Levine

    2005-01-01

    Public policy debates and theoretical disputes motivate this paper%u2019s examination of (i) the relationship between bank concentration and banking system fragility and (ii) the mechanisms underlying this relationship. We find no support for the view that concentration increases the fragility of banks. Rather, banking system concentration is associated with a lower probability that the country suffers a systemic banking crisis. In terms of policies, we find that (i) regulations and instituti...

  16. Balo`s concentric sclerosis: MRI

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C.J. [Department of Radiology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei (Taiwan, Province of China); Ro, L.S. [Department of Neurology, Chang Gung Memorial Hospital, Taipei (Taiwan, Province of China); Wang, L.J. [Department of Radiology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei (Taiwan, Province of China); Wong, Y.C. [Department of Radiology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei (Taiwan, Province of China)

    1996-05-01

    We report a case of Balo`s concentric sclerosis. In the past, the diagnosis was usually made post mortem. In this case, we found that CT demonstrated only low-density lesions, but not their concentric pattern. However, MRI showed a striking feature, reminiscent of histopathology of Balo`s concentric sclerosis, and played an important role in antemortem diagnosis of this rare demyelinating disease. (orig.). With 3 figs.

  17. Concentration of 'forgotten' substances using the XAD concentration method. Suitability of the method for hydrophilic chemicals

    NARCIS (Netherlands)

    Collombon MT; LER

    2007-01-01

    Concentration of forgotten substances using the XAD concentration method In the nineties, RIVM developed a method to concentrate toxic substances on XAD (a synthetic resin). Using bioassays, the toxicity can be determined in the concentrate. 'Modern' toxic substances tend to be more polar then

  18. A concentration inequality for product spaces

    OpenAIRE

    Dodos, Pandelis; Kanellopoulos, Vassilis; Tyros, Konstantinos

    2014-01-01

    We prove a concentration inequality which asserts that, under some mild regularity conditions, every random variable defined on the product of sufficiently many probability spaces exhibits pseudorandom behavior.

  19. Prescribing dialysate bicarbonate concentrations for hemodialysis patients.

    Science.gov (United States)

    Heineken, F G; Brady-Smith, M; Haynie, J; Van Stone, J C

    1988-01-01

    A rearranged equation of Sargent and Gotch (1) was used to determine dialysate bicarbonate concentrations for hemodialysis patients. Parameters in this equation include an estimate of the acid generated by each patient between treatments, an estimate for the dialyzer dialysance for bicarbonate, ultrafiltration rate, blood flow rate and a targeted mid-dialysis plasma bicarbonate concentration of 25 mEq/L. Nine patients were studied over a 35 week period to verify this method of determining each patient's dialysate bicarbonate concentration. Prescribed dialysate bicarbonate concentrations for the nine patients varied from 29 to 38 mEq/L with five patients having a prescribed value of 35 mEq/L. After a baseline period of five weeks, five patients switched from a 37 mEq/L acetate dialysate to their prescribed dialysate bicarbonate concentration. Four patients who had already been on bicarbonate dialysis at a concentration of 35 mEq/L were dialyzed with their prescribed dialysate bicarbonate concentrations. Patients were then followed for a study period of 30 weeks. The prescribed dialysate bicarbonate concentration resulted in more normal acid/base chemistries for both groups of patients. The results also demonstrate that chronic hemodialysis patients require individualization of dialysate bicarbonate concentrations.

  20. Neonicotinoid concentrations in UK honey from 2013.

    Science.gov (United States)

    Jones, Ainsley; Turnbull, Gordon

    2016-10-01

    Concentrations of the neonicotinoid insecticides clothianidin, thiamethoxam and imidacloprid were determined in honey collected in Spring 2013 from a variety of locations in England. The honey was produced before the moratorium in the EU on the use of neonicotinoids in pollinator-attractive crops became effective. Neither imidacloprid nor its metabolites were detected in any honey samples. Concentrations of clothianidin ranged from Neonicotinoid concentrations were below those likely to cause any chronic mortality. The concentrations detected should provide a useful baseline against which the effectiveness of the moratorium in reducing exposure of honeybees can be measured. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  1. Circulating omentin concentration increases after weight loss

    Directory of Open Access Journals (Sweden)

    Ricart Wifredo

    2010-04-01

    Full Text Available Abstract Background Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations. Methods Circulating omentin-1 (ELISA concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women before and after hypocaloric weight loss. Results Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p Conclusion As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.

  2. Light funnel concentrator panel for solar power

    Science.gov (United States)

    1987-01-01

    The solar concentrator design concept provides a theoretical concentration efficiency of 96 percent with power-to-weight ratios as high as 50 W/kg. Further, it eliminates the need for fragile reflective coatings and is very tolerant to pointing inaccuracies. The concept differs from conventional reflective mirrors and lens design in that is uses the principle of total internal reflection in order to funnel incident sunlight into a concentrator photovoltaic cell. The feasibility of the light funnel concentrator concept was determined through a balanced approach of analysis, development, and fabrication of prototypes, and testing of components. A three-dimensional optical model of the light funnel concentrator and photovoltaic cell was developed in order to assess the ultimate performance of such systems. In addition, a thermal and structural analysis of a typical unit was made. Techniques of fabricating the light funnel cones, optically coupling them to GaAs concentrator cells, bonding the funnels to GaAs cells, making electrical interconnects, and bonding substrates was explored and a prototype light funnel concentrator unit was fabricated and tested. Testing of the system included measurements of optical concentrating efficiency, optical concentrator to cell coupling efficiency, and electrical efficiency.

  3. Stopping Criteria for Log-Domain Diffeomorphic Demons Registration: An Experimental Survey for Radiotherapy Application.

    Science.gov (United States)

    Peroni, M; Golland, P; Sharp, G C; Baroni, G

    2016-02-01

    A crucial issue in deformable image registration is achieving a robust registration algorithm at a reasonable computational cost. Given the iterative nature of the optimization procedure an algorithm must automatically detect convergence, and stop the iterative process when most appropriate. This paper ranks the performances of three stopping criteria and six stopping value computation strategies for a Log-Domain Demons Deformable registration method simulating both a coarse and a fine registration. The analyzed stopping criteria are: (a) velocity field update magnitude, (b) mean squared error, and (c) harmonic energy. Each stoping condition is formulated so that the user defines a threshold ∊, which quantifies the residual error that is acceptable for the particular problem and calculation strategy. In this work, we did not aim at assigning a value to e, but to give insights in how to evaluate and to set the threshold on a given exit strategy in a very popular registration scheme. Experiments on phantom and patient data demonstrate that comparing the optimization metric minimum over the most recent three iterations with the minimum over the fourth to sixth most recent iterations can be an appropriate algorithm stopping strategy. The harmonic energy was found to provide best trade-off between robustness and speed of convergence for the analyzed registration method at coarse registration, but was outperformed by mean squared error when all the original pixel information is used. This suggests the need of developing mathematically sound new convergence criteria in which both image and vector field information could be used to detect the actual convergence, which could be especially useful when considering multi-resolution registrations. Further work should be also dedicated to study same strategies performances in other deformable registration methods and body districts. © The Author(s) 2014.

  4. Deep Adaptive Log-Demons: Diffeomorphic Image Registration with Very Large Deformations

    Directory of Open Access Journals (Sweden)

    Liya Zhao

    2015-01-01

    Full Text Available This paper proposes a new framework for capturing large and complex deformation in image registration. Traditionally, this challenging problem relies firstly on a preregistration, usually an affine matrix containing rotation, scale, and translation and afterwards on a nonrigid transformation. According to preregistration, the directly calculated affine matrix, which is obtained by limited pixel information, may misregistrate when large biases exist, thus misleading following registration subversively. To address this problem, for two-dimensional (2D images, the two-layer deep adaptive registration framework proposed in this paper firstly accurately classifies the rotation parameter through multilayer convolutional neural networks (CNNs and then identifies scale and translation parameters separately. For three-dimensional (3D images, affine matrix is located through feature correspondences by a triplanar 2D CNNs. Then deformation removal is done iteratively through preregistration and demons registration. By comparison with the state-of-the-art registration framework, our method gains more accurate registration results on both synthetic and real datasets. Besides, principal component analysis (PCA is combined with correlation like Pearson and Spearman to form new similarity standards in 2D and 3D registration. Experiment results also show faster convergence speed.

  5. Invariance of the distributional curvature of the cone under smooth diffeomorphisms

    Science.gov (United States)

    Vickers, J. A.; Wilson, J. P.

    1999-02-01

    An explicit calculation is carried out to show that the distributional curvature of a 2-cone, calculated by Clarke et al (Clarke C J S, Vickers J A and Wilson J P 1996 Class. Quantum Grav. 13 2485-98), using Colombeau's new generalized functions is invariant under nonlinear 0264-9381/16/2/019/img1 coordinate transformations.

  6. Freesurfer-initialized large deformation diffeomorphic metric mapping with application to Parkinson's disease

    Science.gov (United States)

    Chen, Jingyun; Palmer, Samantha J.; Khan, Ali R.; Mckeown, Martin J.; Beg, Mirza Faial

    2009-02-01

    We apply a recently developed automated brain segmentation method, FS+LDDMM, to brain MRI scans from Parkinson's Disease (PD) subjects, and normal age-matched controls and compare the results to manual segmentation done by trained neuroscientists. The data set consisted of 14 PD subjects and 12 age-matched control subjects without neurologic disease and comparison was done on six subcortical brain structures (left and right caudate, putamen and thalamus). Comparison between automatic and manual segmentation was based on Dice Similarity Coefficient (Overlap Percentage), L1 Error, Symmetrized Hausdorff Distance and Symmetrized Mean Surface Distance. Results suggest that FS+LDDMM is well-suited for subcortical structure segmentation and further shape analysis in Parkinson's Disease. The asymmetry of the Dice Similarity Coefficient over shape change is also discussed based on the observation and measurement of FS+LDDMM segmentation results.

  7. Deep Adaptive Log-Demons: Diffeomorphic Image Registration with Very Large Deformations.

    Science.gov (United States)

    Zhao, Liya; Jia, Kebin

    2015-01-01

    This paper proposes a new framework for capturing large and complex deformation in image registration. Traditionally, this challenging problem relies firstly on a preregistration, usually an affine matrix containing rotation, scale, and translation and afterwards on a nonrigid transformation. According to preregistration, the directly calculated affine matrix, which is obtained by limited pixel information, may misregistrate when large biases exist, thus misleading following registration subversively. To address this problem, for two-dimensional (2D) images, the two-layer deep adaptive registration framework proposed in this paper firstly accurately classifies the rotation parameter through multilayer convolutional neural networks (CNNs) and then identifies scale and translation parameters separately. For three-dimensional (3D) images, affine matrix is located through feature correspondences by a triplanar 2D CNNs. Then deformation removal is done iteratively through preregistration and demons registration. By comparison with the state-of-the-art registration framework, our method gains more accurate registration results on both synthetic and real datasets. Besides, principal component analysis (PCA) is combined with correlation like Pearson and Spearman to form new similarity standards in 2D and 3D registration. Experiment results also show faster convergence speed.

  8. Analyticity of the SRB measure of a lattice of Anosov diffeomorphisms of the torus

    CERN Document Server

    Bonetto, F; Giuliani, A

    2003-01-01

    We consider the "thermodynamic limit" of a d-dimensional lattice of hyperbolic dynamical systems on the 2-torus, interacting via weak and nearest neighbor coupling. We prove that the SRB measure is analytic in the strength of the coupling. The proof is based on symbolic dynamics techniques that allow us to map the SRB measure into a Gibbs measure for a spin system on a (d+1)-dimensional lattice. This Gibbs measure can be studied by an extension (decimation) of the usual "cluster expansion" techniques.

  9. Colour-kinematics duality and the Drinfeld double of the Lie algebra of diffeomorphisms

    Science.gov (United States)

    Fu, Chih-Hao; Krasnov, Kirill

    2017-01-01

    Colour-kinematics duality suggests that Yang-Mills (YM) theory possesses some hidden Lie algebraic structure. So far this structure has resisted understanding, apart from some progress in the self-dual sector. We show that there is indeed a Lie algebra behind the YM Feynman rules. The Lie algebra we uncover is the Drinfeld double of the Lie algebra of vector fields. More specifically, we show that the kinematic numerators following from the YM Feynman rules satisfy a version of the Jacobi identity, in that the Jacobiator of the bracket defined by the YM cubic vertex is cancelled by the contribution of the YM quartic vertex. We then show that this Jacobi-like identity is in fact the Jacobi identity of the Drinfeld double. All our considerations are off-shell. Our construction explains why numerators computed using the Feynman rules satisfy the colour-kinematics at four but not at higher numbers of points. It also suggests a way of modifying the Feynman rules so that the duality can continue to hold for an arbitrary number of gluons. Our construction stops short of producing explicit higher point numerators because of an absence of a certain property at four points. We comment on possible ways of correcting this, but leave the next word in the story to future work.

  10. Inflammation Is Associated with Voriconazole Trough Concentrations

    Science.gov (United States)

    van Wanrooy, Marjolijn J. P.; Span, Lambert F. R.; Rodgers, Michael G. G.; van den Heuvel, Edwin R.; Uges, Donald R. A.; van der Werf, Tjip S.; Kosterink, Jos G. W.

    2014-01-01

    Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-reactive protein (CRP) concentrations, and voriconazole trough concentrations. A retrospective chart review of patients with at least one steady-state voriconazole trough concentration and a CRP concentration measured on the same day was performed. A total of 128 patients were included. A significantly (P voriconazole trough concentration was observed in patients with severe inflammation (6.2 mg/liter; interquartile range [IQR], 3.4 to 8.7 mg/liter; n = 20) than in patients with moderate inflammation (3.4 mg/liter; IQR, 1.6 to 5.4 mg/liter; n = 60) and in patients with no to mild inflammation (1.6 mg/liter; IQR, 0.8 to 3.0 mg/liter; n = 48). The patients in all three groups received similar voriconazole doses based on mg/kg body weight (P = 0.368). Linear regression analyses, both unadjusted and adjusted for covariates of gender, age, dose, route of administration, liver enzymes, and interacting coadministered medications, showed a significant association between voriconazole and CRP concentration (P voriconazole trough concentration increased by 0.015 mg/liter (unadjusted 95% confidence interval [CI], 0.011 to 0.020 mg/liter; adjusted 95% CI, 0.011 to 0.019 mg/liter). Inflammation, reflected by the C-reactive protein concentration, is associated with voriconazole trough concentrations. Further research is necessary to assess if taking the inflammatory status of a patient into account is helpful in therapeutic drug monitoring of voriconazole to maintain concentrations in the therapeutic window, thereby possibly preventing suboptimal treatment or adverse events. PMID:25223994

  11. Renæssancen i svøb

    DEFF Research Database (Denmark)

      Hvornår holder middelalderen op og afløses af renæssancen? Og kan det virkelig passe at renæssancen i Danmark først slår igennem 150 år efter den italienske? Disse spørgsmål mødtes en række forskere og specialister om og diskuterede i det danske renæssanceår 2006. Resultatet blev 13 nye bidrag ...

  12. Derfor er Fodbold Fitness svær at udbrede

    DEFF Research Database (Denmark)

    Bennike, Søren

    2016-01-01

    DBU ønsker at udbrede Fodbold Fitness som en ny og anderledes måde at organisere og dermed 'gå til fodbold på'. Imidlertid udfordrer organiseringen af foreningsfodbold dette ønske, skriver idrætsforsker Søren Bennike i denne artikel.......DBU ønsker at udbrede Fodbold Fitness som en ny og anderledes måde at organisere og dermed 'gå til fodbold på'. Imidlertid udfordrer organiseringen af foreningsfodbold dette ønske, skriver idrætsforsker Søren Bennike i denne artikel....

  13. Světový trh kávy

    OpenAIRE

    Vachová, Lucie

    2010-01-01

    My bachelor's thesis on the topic "The World Coffee Market" divides in three main chapters: "Production and Processing of Coffee", "Analysis of the World Coffee Market" and "Future Development and Prospects on the Coffee Market". The first chapter deals with the origin of coffee, coffee trees, harvesting and processing of coffee with different methods and also with preparing and dining of coffee. The second chapter, which is fundamental chapter of my thesis, analyses the world coffee market. ...

  14. Cyklodextriny ve světě polymerů

    Czech Academy of Sciences Publication Activity Database

    Horský, Jiří; Jindřich, J.

    2013-01-01

    Roč. 107, č. 10 (2013), s. 769-776 ISSN 0009-2770 Institutional support: RVO:61389013 Keywords : cyclodextrin s * polymers * pseudopolyrotaxanes Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.196, year: 2013 http://www.chemicke-listy.cz/common/article-vol_107-issue_10-page_769.html

  15. Svømmetilbud målrettet etniske kvinder

    DEFF Research Database (Denmark)

    Andersen, Pernille Tanggaard; Kronborg Bak, Carsten; Tykgaard Clausen, Camilla

    2014-01-01

    Evaluation of a swimming-intervention targeting female ethnical minorities. A health-promoting intervention in Korskærparken, established by the municipality of Fredericia, has been evaluated to identify potentials and barriers in health promotion targeting ethnic minorities. Factors that had...

  16. Svært at skille roller ad

    DEFF Research Database (Denmark)

    Søgaard, Villy

    2007-01-01

    Foranlediget af professor Bent Jensens avisomtale af Jørgen Dragsdahl som spion under den kolde krig, forfægter artiklen det principielle synspunkt, at forskningsresultater som hovedregel bør publiceres ad de sædvanlige forskningsmæssige kanaler, før de kommer i avisen. Dette gælder specielt, hvo...

  17. Kuba - diktatura ve světě demokracie

    OpenAIRE

    Vodraška, Martin

    2012-01-01

    The first chapter describes basic information about the country - location, geography and population. The second chapter deals with historical events of Cuba and analysis of their individual economic consequences. The third chapter analyzes the political and social system of Cuba. The fourth chapter sets out the main attributes of the economy today and the relationship to democracy. The last chapter of the thesis tries to predict the possible future development.

  18. Fristelsen og det svære valg

    DEFF Research Database (Denmark)

    Smed, Sinne

    2013-01-01

    Selvkontrol er en væsentlig faktor for, hvor godt det lykkes for os at leve op til de mål vi sætter for os selv. Men hvor gode vi er til at kontrollere os selv er måske ikke kun en medfødt eller i barndommen tillært evne, men kan også afhænge af, hvor mange andre ting vi har at slås med i hverdag...

  19. Nedtur. Griske prinser svækker Saudi-Arabien

    DEFF Research Database (Denmark)

    Schmidt, Søren

    2016-01-01

    I analyze the ability of Saudi-Arabia to adjust to present low oil prices. I analyze the political foundations of the Saudi state and its weak autonomy in relation to its power bases: the avaricious princes and the fundamentalist religious Sheikhs. I am pessimistic as to the likelyhood of Saudi...

  20. Den initiale behandling af svært tilskadekomne traumepatienter

    DEFF Research Database (Denmark)

    Steinmetz, Jacob; Svendsen, Lars Bo

    2014-01-01

    Multitrauma is usually defined as injury to several organ systems. The more severe the injury, the higher is the mortality. It is essential that a trauma team assess and treat these patients using a rapid, structured approach in order to increase the survival. Damage control surgery and resuscita......Multitrauma is usually defined as injury to several organ systems. The more severe the injury, the higher is the mortality. It is essential that a trauma team assess and treat these patients using a rapid, structured approach in order to increase the survival. Damage control surgery...

  1. Concordia Klar, SV kunstipreemia laureaat / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2011-01-01

    1984. aasta kevadnäitusele esitatud Concordia Klari vabagraafilistest lehtedest ja illustratsioonide sarjast Jaan Krossi romaanile "Kolme katku vahel" pealkirjaga "Tallinn ja aeg", millega ta pälvis Vilniuses Baltimaade raamatukunsti triennaalil peapreemia ning ajalehe "Sirp ja Vasar" kunstipreemia

  2. Svítidla a aplikace s Power LED zdroji

    OpenAIRE

    Vaňko, Adam

    2011-01-01

    Pokrok vo vývoji moderných LED, ich dlhá životnosť a vysoký merný výkon predurčujú ich použitie v osvetľovacích systémoch. Práca je venovaná možnoti aplikácie LED v svietidlách, parametrom diód a problémom, ktoré sa pri konštrukcii svietidiel s LED svetelným zdrojom môžu vyskytnúť. Praktická časť práce rieši návrh svietidla určeného k osvetľovaniu dopravných značiek, vertikálnych plôch, bilboardov a fasád. Pri komplexnom návrhu sa zohľadňujú normami predpísané parametre osvetľovacieho systému...

  3. Věříte svému policistovi?

    Czech Academy of Sciences Publication Activity Database

    Březinová, Kristina

    2013-01-01

    Roč. 24, č. 10 (2013), s. 32-34 ISSN 1210-1168 Institutional support: RVO:68378025 Keywords : general trust in police * citizen´s opinions about policmen * police corruption Subject RIV: AO - Sociology, Demography http://data.idnes.cz/mfdnes/kavarna/pdf/2013/kavarna-20130112.pdf

  4. Kostel sv. Václava v Žamberku

    OpenAIRE

    Kreuselová, Zuzana

    2015-01-01

    Diploma thesis "St. Wenceslas Church in Žamberk" discusses the church monographically. Initially, it briefly introduces the city, its origin, estate owners and then chronologically from art-historical terms the most important foundations of building Bubnů of Litic. Afterwards we focus our attention on the church, its history and construction, parish building, description, and especially the valuable furniture. In this part the thesis deals with baroque altars and particularly the main altar c...

  5. Sea salt concentrations across the European continent

    NARCIS (Netherlands)

    Manders, A.M.M.; Schaap, M.; Querol, X.; Albert, M.F.M.A.; Vercauteren, J.; Kuhlbusch, T.A.J.; Hoogerbrugge, R.

    2010-01-01

    The oceans are a major source for particles that play an important role in many atmospheric processes. In Europe sea salt may contribute significantly to particulate matter concentrations. We have compiled sodium concentration data as a tracer for sea salt for 89 sites in Europe to provide more

  6. Filterability and Sludge Concentration in Membrane Bioreactors

    NARCIS (Netherlands)

    Lousada-Ferreira, M.

    2011-01-01

    The Thesis entitled “Filterability and Sludge Concentration in Membrane Bioreactors” aims at explaining the relation between Mixed Liquid Suspended Solids (MLSS) concentration, the amount of solids in the wastewater being treated, also designated as sludge, and filterability, being the ability of

  7. Diagnostic patch test concentration for Kathon CG.

    Science.gov (United States)

    Maibach, H I

    1985-10-01

    Patch test studies, 21-day cumulative irritancy assays and Draize repeat insult patch tests with Kathon CG, were used to ascertain an appropriate diagnostic patch test concentration. A dilution of 100 ppm a.i. (aq. or pet.) appears to have low irritancy potential. Further observations are required to verify if this concentration is high enough to detect most cases of sensitization.

  8. Program for Area Concentration Achievement Testing.

    Science.gov (United States)

    Golden, Anthony J.

    The Program for Area Concentration Achievement Testing (PACAT) produces the cooperative assessment instrument known as the Area Concentration Achievement Test (ACAT). The ACAT uses a model designed specifically to measure curricular strengths and weaknesses and to provide this information at the departmental level. PACAT has developed 57…

  9. A Novel Method for Detergent Concentration Determination

    National Research Council Canada - National Science Library

    Kaufmann, Thomas C; Engel, Andreas; Rémigy, Hervé-W

    2006-01-01

    ... present (5,6) . Therefore, the detergent concentration needs to be accurately measured. Although quite a few methods exist for the determination of detergent concentrations, they are impractical for many routine applications. They include the use of radiolabeled detergents (7) , Fourier transform infrared spectroscopy (8) , quantit...

  10. Electrochemical phosphate recovery from nanofiltration concentrates

    NARCIS (Netherlands)

    Kappel, C.; Yasadi, K.; Temmink, B.G.; Metz, S.J.; Kemperman, A.J.B.; Nijmeijer, K.; Zwijnenburg, A.; Witkamp, G.J.; Rijnaarts, H.

    2013-01-01

    The high total phosphorus content of raw domestic wastewater with its significant eutrophication potential offers an excellent possibility for phosphate recovery. Continuous recirculation of NF concentrate to an MBR and simultaneous phosphate recovery from the NF concentrate can be applied to

  11. Metamaterial anisotropic flux concentrators and magnetic arrays

    DEFF Research Database (Denmark)

    Bjørk, Rasmus; Smith, Anders; Bahl, Christian R.H.

    2013-01-01

    A metamaterial magnetic flux concentrator is investigated in detail in combination with a Halbach cylinder of infinite length. A general analytical solution to the field is determined and the magnetic figure of merit is determined for a Halbach cylinder with a flux concentrator. It is shown...

  12. Monitoring the intake of pasture and concentrates

    African Journals Online (AJOL)

    administrator

    Feeding systems in which young ostriches feed on pasture but have access to concentrates provide better welfare .... and 3 were fed concentrate, provided at 20 (n = 4) and 30 (n = 4) g/kg BW, respectively, and also grazed for. 4-6 h daily as ..... Faecal spectroscopy (NIRS) for nutritional profiling of dairy cattle. Proc. VI Intl.

  13. Metal concentrations in water column, benthic macroinvertebrates ...

    African Journals Online (AJOL)

    Concentrations of some metals in the water, benthic macroinvertebrates and the muscle tissue of the Nile tilapia from river Delimi, Nigeria were investigated from January 1998 to June 1998. Samplings were done monthly at 3 different sites. The concentrations of the metals were determined using the atomic absorption ...

  14. enhanced ultrafiltration at low surfactant concentrations

    African Journals Online (AJOL)

    2006-04-24

    Apr 24, 2006 ... Micellar-enhanced ultrafiltration (MEUF) of zinc ions (Zn2+) from aqueous solutions using single anionic surfactant sodium dodecyl sulphate (SDS) at low critical micelle concentrations (cmc) (0.2×cmc – 3×cmc) was investigated. When the initial. SDS concentration was below the cmc, unexpectedly high ...

  15. Concentration inequalities for random fields via coupling

    NARCIS (Netherlands)

    Chazottes, J. R.; Collet, P.; Kuelske, C.; Redig, F.

    We present a new and simple approach to concentration inequalities in the context of dependent random processes and random fields. Our method is based on coupling and does not use information inequalities. In case one has a uniform control on the coupling, one obtains exponential concentration

  16. Market power, industrial concentration and innovative activity

    NARCIS (Netherlands)

    Vossen, RW

    1999-01-01

    This paper discusses the paradox between the positive effect of industrial concentration on R & D spending, and its non-positive effect on the number of innovations. Also, I analyze whether concentration has different effects on small- and large-firm R & D. The analysis shows that the positive

  17. Stress Concentration around Holes in Anistropic Sheets

    DEFF Research Database (Denmark)

    Krenk, Steen

    1979-01-01

    The formulation of stress concentration problems of plane anisotropic elasticity in terms of integral equations is discussed. First the singular solutions of a concentrated force and a dislocation are formulated so that they remain valid in the case of double roots. The distribution...

  18. Gentamicin concentrations in human subcutaneous tissue

    DEFF Research Database (Denmark)

    Lorentzen, Hanne; Kallehave, Finn Lasse; Kolmos, Hans Jørn Jepsen

    1996-01-01

    Wound infections frequently originate from the subcutaneous tissue. The effect of gentamicin in subcutaneous tissue has, however, normally been evaluated from concentrations in blood or wound fluid. The aim of the present study was to investigate the pharmacokinetic properties of gentamicin in hu...... the presence of sufficient concentrations in the adipose tissue to be effective against common bacteria....

  19. Assessment of specific activity concentration and percentage ...

    African Journals Online (AJOL)

    survey of radioactivity concentration in soil and water from the Port Harcourt refinery company host community was carried out using the gamma ray spectrometer with NaI(TI) detector to determine the concentration of the primordial radionuclides 226Ra, 232Th and 40K. 20 samples (10 each of soil and water) were collected ...

  20. EFFECTIVE SEPARATION OF GALENA CONCENTRATE FROM ...

    African Journals Online (AJOL)

    Separation of a clean galena (lead sulphide) concentrate from the mixture of galena and quartz by tabling operation has been investigated. The Nigerian Lead ore composed mainly lead sulphide and quartz. Tabling method was employed on the ore as a method of gravity concentration. The mineral constituents of the ore ...

  1. 21 CFR 155.191 - Tomato concentrates.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Tomato concentrates. 155.191 Section 155.191 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR... considered added salt). (ii) Lemon juice, concentrated lemon juice, or organic acids. (iii) Sodium...

  2. Cream concentrated latex for foam rubber products

    Science.gov (United States)

    Suksup, R.; Imkaew, C.; Smitthipong, W.

    2017-12-01

    Fresh natural latex (around 40% rubber and 60% water) can be transformed to concentrated natural latex (around 60% rubber and 40% water) in order to realise economical transportation and easier latex product’s preparation. The concentrated natural latex is an extremely valuable material. It can be applied for many types of products, for example, foam rubber as pillow and mattress, elastic band, etc. Industrially, the concentrated natural latex can be prepared by centrifugation which requires an enormous expensive machine. From the eco-friendly products point of view, most of rubber entrepreneurs in the world try to develop a green rubber product. So, the main objective of this study is to prepare the cream concentrated latex without any sophisticated machine. Thus, we work on a simple, cheap and green method that does not use any expensive machine but uses water-based chemical as sodium alginate to prepare the cream concentrated latex. The optimal amount of sodium alginate in the latex was studied. The main characteristics of the cream concentrated latex were tested by various technics, such as alkalinity, total solid content (TSC), dry rubber content (DRC), etc. We found that there are no significant differences of results between fresh natural latex and cream concentrated latex, except for the TSC and DRC. The TSC and DRC of cream latex are higher than those of fresh natural latex. Finally, we propose a model of natural rubber particle and sodium alginate to form the cream concentrated latex.

  3. Current Status of Concentrator Photovoltaic (CPV) Technology

    Energy Technology Data Exchange (ETDEWEB)

    Philipps, Simon P. [Fraunhofer Inst. for Solar Energy Systems ISE, Freiburg (Germany); Bett, Andreas W. [Fraunhofer Inst. for Solar Energy Systems ISE, Freiburg (Germany); Horowitz, Kelsey [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kurtz, Sarah [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-12-01

    This report summarizes the status of the concentrator photovoltaic (CPV) market and industry as well as current trends in research and technology. This report is intended to guide research agendas for Fraunhofer ISE, the National Renewable Energy Laboratory (NREL), and other R&D organizations. Version 1.1 of this report includes recent progress in CPV. The recent record module efficiency of 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve.

  4. Concentration inequalities for sums and martingales

    CERN Document Server

    Bercu, Bernard; Rio, Emmanuel

    2015-01-01

    The purpose of this book is to provide an overview of historical and recent results on concentration inequalities for sums of independent random variables and for martingales. The first chapter is devoted to classical asymptotic results in probability such as the strong law of large numbers and the central limit theorem. Our goal is to show that it is really interesting to make use of concentration inequalities for sums and martingales. The second chapter deals with classical concentration inequalities for sums of independent random variables such as the famous Hoeffding, Bennett, Bernstein and Talagrand inequalities. Further results and improvements are also provided such as the missing factors in those inequalities. The third chapter concerns concentration inequalities for martingales such as Azuma-Hoeffding, Freedman and De la Pena inequalities. Several extensions are also provided. The fourth chapter is devoted to applications of concentration inequalities in probability and statistics.

  5. Postmortem Femoral Blood Concentrations of Risperidone

    DEFF Research Database (Denmark)

    Linnet, Kristian; Johansen, Sys Stybe

    2014-01-01

    Postmortem femoral blood concentrations of the antipsychotic drug risperidone and the active metabolite 9-hydroxyrisperidone were determined by an achiral LC-MS/MS method in 38 cases. The cause of death was classified as unrelated to risperidone in 30 cases, in which the sum of the concentration...... of the drug and metabolite ranged from below the limit of quantification to 0.058 mg/kg (median 0.0098 mg/kg). This concentration range, which largely corresponds to published in vivo plasmalevels under therapy, may serve as a reference for judgment of postmortem cases involving risperidone. In one case......, risperidone was judged to be a contributing factor to death, and the sum of concentrations was 0.29 mg/kg. This concentration is of the same order of magnitude as observed for plasma levels in clinical intoxication cases. For the remaining seven cases, the cause of death was unclear. The measurements observed...

  6. Corundum dissolution in concentrated sodium hydroxide solution

    Directory of Open Access Journals (Sweden)

    u-sheng Wu

    2016-11-01

    Full Text Available The corundum (α-alumina core has been considered as a suitable candidate for investment casting of hollow, high pressure turbine engine airfoils due to its excellent properties. However, the efficiency of removing alumina cores in concentrated caustic solution cannot meet the needs of industrial production. In this paper, the effects of temperature and initial solution concentration on dissolution of α-alumina were studied by the classical weight-loss method. The fractal kinetic model was developed in order to describe α-alumina dissolution, assuming that the nonporous particles shrank during reaction process. The results show that the dissolution rate increases with increasing reaction temperature and initial solution concentration. Especially, the initial solution concentration has a significant influence on α-alumina dissolution rate at a higher reaction temperature. The activation energies decrease with increasing initial solution concentration, and the chemical reaction is the rate-controlling step.

  7. Ammonia concentrations in houses and public buildings

    Science.gov (United States)

    Tidy, Georgia; Neil Cape, J.

    Weekly average concentrations of ammonia were measured in winter 1991-1992 in different rooms in houses and in a range of public buildings using passive diffusion tubes. Concentrations of NH 3 ranging from 6 to 53 ppb were found in different rooms within a house. Concentrations in living rooms of 5 houses ranged from 7 to 63 ppb, with the largest values in rooms used by smokers. Concentrations of NH 3 in public buildings were similar to those in houses, with concentrations in areas used for social activity greater than in work areas. These preliminary data suggest that the factors controlling the sources and sinks of NH 3 indoors should be studied in greater detail, including the role of tobacco smoke.

  8. Atmospheric relative concentrations in building wakes

    Energy Technology Data Exchange (ETDEWEB)

    Ramsdell, J.V. Jr.; Simonen, C.A.; Smyth, S.B. [Pacific Northwest Lab., Richland, WA (United States)

    1995-05-01

    This report documents the ARCON95 computer code developed for the U.S. Nuclear Regulatory Commission Office of Nuclear Regulatory Research for use in control room habitability assessments. The document includes a user`s guide to the code, a description of the technical basis for the code, and a programmer`s guide to the code. The ARCON95 code uses hourly meteorological data and recently developed methods for estimating dispersion in the vicinity of buildings to calculate relative concentrations at control room air intakes that would be exceeded no more five percent of the time. These concentrations are calculated for averaging periods ranging from one hour to 30 days in duration. Relative concentrations calculated by ARCON95 are significantly lower than concentrations calculated using the currently accepted procedure when winds are less than two meters per second. For higher wind speeds, ARCON95 calculates about the same concentrations as the current procedure.

  9. Plasma fibronectin concentrations in morbidly obese patients

    DEFF Research Database (Denmark)

    Dejgaard, A; Andersen, T; Christoffersen, Pernille Yde

    1984-01-01

    Plasma fibronectin concentrations and liver morphology were investigated in 45 morbidly obese subjects (median overweight 88%) and in 42 normal weight controls, matched for sex and age. A significantly (P less than 0.01) raised plasma fibronectin concentration (median 464 mg/l, range 276-862 mg....../l) was found in the obese subjects when compared with concentrations in the controls (median 348 mg/l, range 164-536 mg/l). Plasma fibronectin concentrations of the obese patients correlated significantly to their degree of overweight (r = 0.33, P less than 0.05) as well as to the degree of fatty change found...... in their liver biopsies (r = 0.33, P less than 0.05). Significantly (P less than 0.05) elevated plasma fibronectin concentrations even in obese subjects without hepatic fatty change indicate that liver fat accumulation is no prerequisite of the obesity-related elevation of plasma fibronectin. Raised plasma...

  10. Cord blood copeptin concentrations in fetal macrosomia.

    Science.gov (United States)

    Briana, Despina D; Baka, Stavroula; Boutsikou, Maria; Boutsikou, Theodora; Xagorari, Marieta; Gourgiotis, Dimitrios; Malamitsi-Puchner, Ariadne

    2016-01-01

    Excessive fetal growth is associated with increased adiposity and reduced insulin sensitivity at birth. Copeptin, a surrogate marker of arginine vasopressin (AVP) secretion, is upregulated in states of hyperinsulinemia and is considered one of the mediators of insulin resistance. We aimed to investigate cord blood concentrations of copeptin (C-terminal fragment of AVP pro-hormone) in healthy large-for-gestational-age (LGA) infants at term. This prospective study was conducted on 30 LGA (n=30) and 20 appropriate-for-gestational-age (AGA, n=20) singleton full-term healthy infants. Cord blood copeptin and insulin concentrations were determined by ELISA and IRMA, respectively. Infants were classified as LGA or AGA, based on customized birth-weight standards adjusted for significant determinants of fetal growth. Cord blood copeptin concentrations were similar in LGA cases, compared to AGA controls, after adjusting for delivery mode. However, in the LGA group, cord blood copeptin concentrations positively correlated with birth-weight (r=0.422, p=0.020). In the AGA group, cord blood copeptin concentrations were elevated in cases of vaginal delivery vs elective cesarean section (p=0.003). Cord blood insulin concentrations were higher in LGA cases, compared to AGA controls (p=0.036). No association was recorded between cord blood copeptin concentrations and maternal age, parity, gestational age or fetal gender in both groups. Cord blood copeptin concentrations may not be up-regulated in non-distressed LGA infants. However, the positive correlation between cord blood copeptin concentrations and birth-weight in the LGA group may point to the documented association between AVP release and increased fat deposition. Vaginal delivery vs elective cesarean section is accompanied by a marked stress-related increase of cord blood copeptin concentrations. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. [Relationship between dust mass concentration and fiber number concentration of refractory ceramic fibers].

    Science.gov (United States)

    Zhu, Xiaojun; Li, Tao; Wang, Hongfei

    2015-04-01

    To explore the quantitative relationship between the dust mass concentration and fiber number concentration of refractory ceramic fibres. A typical refractory ceramic fiber plant was selected as the study site. Fifty-three paired samples of total dust mass concentration and fiber number concentration were collected using the long-time fixed site mode. The total dust mass concentration was measured according to the GBZ/T 192.1-2007 (Measurement of dust in the air of workplace, part 1: Total dust concentration). Membrane filter method/phase-contrast optical microscopy was used to determine the fiber number concentration. Univariate analysis was used to describe the distribution of the two concentrations and their ratio. Spearman rank correlation, as well as linear regression, logarithmic curve, polynomial, power function, and exponential curve model, were used to explore the relationship between the two concentrations. Results The range of the total dust mass concentration (x) was 0.45-13.82 mg/m3. The range of the fiber number concentration (y) was 0.01-1.04 f/ml. The range of the ratio (x/y) was 4-158. All of the three parameters did not follow normal distribution (Pfiber number concentration of refractory ceramic fibers. However, there is no fixed regression relationship between the two concentrations, and neither is a definite coefficient which can be used to convert each other. The two concentrations cannot be replaced by each other.

  12. Extracting and Applying SV-SV Shear Modes from Vertical Vibrator Data Across Geothermal Prospects Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Hardage, Bob [Bureau of Economic Geology

    2013-07-01

    This 3-year project was terminated at the end of Year 1 because the DOE Geothermal project-evaluation committee decided one Milestone was not met and also concluded that our technology would not be successful. The Review Panel recommended a ?no-go? decision be implemented by DOE. The Principal Investigator and his research team disagreed with the conclusions reached by the DOE evaluation committee and wrote a scientifically based rebuttal to the erroneous claims made by the evaluators. We were not told if our arguments were presented to the people who evaluated our work and made the ?no-go? decision. Whatever the case regarding the information we supplied in rebuttal, we received an official letter from Laura Merrick, Contracting Officer at the Golden Field Office, dated June 11, 2013 in which we were informed that project funding would cease and instructed us to prepare a final report before September 5, 2013. In spite of the rebuttal arguments we presented to DOE, this official letter repeated the conclusions of the Review Panel that we had already proven to be incorrect. This is the final report that we are expected to deliver. The theme of this report will be another rebuttal of the technical deficiencies claimed by the DOE Geothermal Review Panel about the value and accomplishments of the work we did in Phase 1 of the project. The material in this report will present images made from direct-S modes produced by vertical-force sources using the software and research findings we developed in Phase 1 that the DOE Review Panel said would not be successful. We made these images in great haste when we were informed that DOE Geothermal rejected our rebuttal arguments and still regarded our technical work to be substandard. We thought it was more important to respond quickly rather than to take additional time to create better quality images than what we present in this Final Report.

  13. Svåra Samtal : En kvalitativ studie om hur professionella inom socialt arbete uppfattar svåra samtal

    OpenAIRE

    Olsson, Carolin; Olsson, Sanna

    2010-01-01

    The aim of this study was to research how social-work professionals apprehend, manage and influence difficult conversation.  This study is based on a qualitative method and we did qualitative interviews with eleven social-work professionals in three municipalities located in southern Sweden. In addition to our research on difficult conversation we decided to study easy conversation. Our result show that there isn’t any special subjects that creates difficult conversation, but it is the absent...

  14. Svømmetilbud målrettet etniske kvinder, Procesevaluering af en svømmeintervention

    Directory of Open Access Journals (Sweden)

    Pernille Tangaard Andersen

    2014-06-01

    Full Text Available Evaluation of a swimming-intervention targeting female ethnical minorities. A health-promoting intervention in Korskærparken, established by the municipality of Fredericia, has been evaluated to identify potentials and barriers in health promotion targeting ethnic minorities. Factors that had a major effect in the success of the intervention were; a nearly cost free arrangement; the target groups ownership in the intervention; the fact that cultural and gender barriers were taken into account and the recruitment of participants through the local community, mentors and other participants. Barriers included dependence on economic support and practical arrangement.

  15. Interpreting Tacrolimus Concentrations During Pregnancy and Postpartum

    Science.gov (United States)

    Hebert, Mary F.; Zheng, Songmao; Hays, Karen; Shen, Danny D.; Davis, Connie L.; Umans, Jason G.; Miodovnik, Menachem; Thummel, Kenneth E.; Easterling, Thomas R.

    2012-01-01

    Summary Pregnancy following solid organ transplantation, although considered high risk for maternal, fetal and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that can increase the fraction of unbound tacrolimus, including but not limited to low albumin concentration and low RBC count. The clinical titration of dosage to maintain whole blood tacrolimus trough concentrations in the usual therapeutic range can lead to elevated unbound concentrations and possibly toxicity in pregnant women with anemia and hypoalbuminemia. Measurement of plasma or unbound tacrolimus concentrations for pregnant women might better reflect the active form of the drug, though these are technically-challenging and often unavailable in usual clinical practice. Tacrolimus crosses the placenta with in utero exposure being approximately 71% of maternal blood concentrations. The lower fetal blood concentrations are likely due to active efflux transport of tacrolimus from the fetus toward the mother by placental P-glycoprotein. To date, tacrolimus has not been linked to congenital malformations, but can cause reversible nephrotoxicity and hyperkalemia in the newborn. In contrast, very small amounts of tacrolimus are excreted in the breast milk and are unlikely to elicit adverse effects in the nursing infant. PMID:23274970

  16. Central tetrahydrobiopterin concentration in neurodevelopmental disorders

    Directory of Open Access Journals (Sweden)

    Richard E Frye

    2010-07-01

    Full Text Available Tetrahydrobiopterin (BH4 is a naturally occurring cofactor essential for critical metabolic pathways. Studies suggest that BH4 supplementation may ameliorate autism symptoms; the biological mechanism for such an effect is unknown. To help understand the relation between central BH4 concentration and systemic metabolism and to develop a biomarker of central BH4 concentration, the relationship between cerebrospinal fluid BH4 concentration and serum amino acids was studied. BH4 concentration was found to be distributed in two groups, a lower and higher BH4 concentration group. Two serum amino acids, citrulline and methionine, differentiated these groups, and the ratio of serum citrulline-to-methionine was found to correlate with the cerebrospinal fluid BH4 concentration (r = -0.67, p < 0.05. Both citrulline and methionine are substrates in inflammation and oxidative stress pathways - two pathways that utilize BH4 and are abnormally activated in autism. These data suggests that central BH4 concentration may be related to systemic inflammation and oxidative stress pathways.

  17. The thermodynamic limits of light concentrators

    Energy Technology Data Exchange (ETDEWEB)

    Smestad, G. (Hewlett Packard Co., San Jose, CA (United States)); Ries, H. (Paul Scherrer Inst., Wuerenlingen (Switzerland)); Winston, R. (Univ. of Chicago, IL (United States)); Yablonovitch, E. (Bell Communications Research, Red Bank, NJ (United States))

    1990-01-01

    Much work has been done over the past 10 years on the concentration of solar radiation using a variety of devices. To concentrate the light, photons from a larger area are collected and directed to a smaller areas. Some devices use geometrical optics, or a change in index of refraction to increase the illumination on a surface above the incident solar level. Other systems use a frequency or Stokes shift to increase the illumination of light at one photon energy at the expense of another. There is often confusion as to the concentration limit imposed by basic physical laws on these different types of systems. Presented is a unification of the ideas and principles developed for the various classifications of concentrators. Equations are developed that describe the limits of concentration in geometrical and fluorescent systems. Concentration is shown to be a function of the index of refraction, angular collection range, as well as the frequency shift. Applications of the ideas involve the understanding of diffuse radiation concentrators and the solar powered laser.

  18. Solar concentrator advanced development program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Knasel, D.; Ehresman, D.

    1989-10-01

    The Solar Concentrator Advanced Development Project has successfully designed, fabricated, and tested a full scale prototypical solar dynamic concentrator for space station applications. A Truss Hexagonal Panel reflector was selected as a viable solar concentrator concept to be used for space station applications. This concentrator utilizes a modular design approach and is flexible in attainable flux profiles and assembly techniques. The detailed design of the concentrator, which included structural, thermal and optical analysis, identified the feasibility of the design and specific technologies that were required to fabricate it. The needed surface accuracy of the reflectors surface was found to be very tight, within 5 mrad RMS slope error, and results in very close tolerances for fabrication. To meet the design requirements, a modular structure composed of hexagonal panels was used. The panels, made up of graphite epoxy box beams provided the strength, stiffness and dimensional stability needed. All initial project requirements were met or exceeded by hardware demonstration. Initial testing of structural repeatability of a seven panel portion of the concentrator was followed by assembly and testing of the full nineteen panel structure. The testing, which consisted of theodolite and optical measurements over an assembly-disassembly-reassembly cycle, demonstrated that the concentrator maintained the as-built contour and optical characteristics. The facet development effort within the project, which included developing the vapor deposited reflective facet, produced a viable design with demonstrated optical characteristics that are within the project goals.

  19. Tocopherol concentrations in platelets in children.

    Science.gov (United States)

    Tatsumi, K; Yaoi, K; Mino, M

    1988-01-01

    To determine the normal range of platelet tocopherol concentrations in childhood, 158 healthy children, 3 months to 15 years old, including 81 males and 77 females were examined and this population was compared with adults. In children, the mean platelet tocopherol concentration was 0.17 micrograms/mg protein, ranging from 0.07 to 0.39 micrograms/mg protein, with a nearly logarithmic distribution. Levels of less than 0.10 micrograms/mg protein were found in only 4 of the 158 subjects. This level may be too low in platelet concentrations for this population of children. Platelet and plasma tocopherol concentrations, and the ratio of plasma tocopherol to total lipids (tocopherol/lipid ratio) in children, excluding the infant group of less than 1 year old, were lower than those in adults. The findings from this population were quite consistent with those of a population previously investigated, with respect to the distribution of plasma and RBC tocopherol concentrations and the tocopherol/lipid ratio. The tocopherol concentrations in plasma, RBCs, and platelets in the infant group were higher than those in the other children's groups (more than 1 year old), and those concentrations were comparable to the adult ones. This may reflect the higher intake of alpha-tocopherol from the prepared formulas containing more than 1,000 micrograms/dl.

  20. VSHOT Measurements of Distal II Dish Concentrators

    Energy Technology Data Exchange (ETDEWEB)

    Jones, S.A.

    1998-12-14

    The Video Scanning Hartmann Optical Tester (VSHOT) is a laser ray-trace tool for measuring the slope error of solar concentrator mirrors. The VSHOT measurements made on two, 8.5-m diameter, Distal II dishes represent its first use on a concentrator installed and operating in the field. A number of valuable lessons were learned regarding the use of the VSHOT for outdoor testing. The two dishes were found to have overall figure-of-merit RMS slope errors from an ideal parabola of 2.99 and 3.18 milliradians. The VSHOT measurements compare well qualitatively with distant observer photographs made using a colored concentric ring target.

  1. Line-focus concentrating collector program

    Science.gov (United States)

    Dugan, V. L.

    1980-01-01

    The Line-Focus Concentrating Collector Program has emphasized the development and dissemination of concentrating solar technology in which the reflected sunlight is focused onto a linear or line receiver. Although a number of different types of line-focus concentrators were developed, the parabolic trough has gained the widest acceptance and utilization within the industrial and applications sectors. The trough is best applied for application scenarios which require temperatures between 140 and 600 F. Another concept, the bowl, is investigated for applications which may require temperatures in the range between 600 and 1200 F. Current technology emphases are upon the reduction of system installation cost and the implementation of production oriented engineering.

  2. Effects of malachite green concentration on heamatological ...

    African Journals Online (AJOL)

    Le poisson chat d'Afrique (Clarias gariepinus) a été exposé à 0.0, 0.10, 0.50, 1.00, 2.0 et 4.5mg / l de la concentration de vert de malachite. La concentration létale (LC5O) du vert de malachite a été 0.38mg / l après 96h d'exposition. L'effet de la concentration sous létale du vert de malachite (0.19mg / l) sur la composition ...

  3. Body and Gender in Nazi Concentration Camps

    Directory of Open Access Journals (Sweden)

    Bożena Karwowska

    2009-01-01

    Full Text Available The article Body and Gender in Nazi Concentration Camps is an attempt to discuss difficult issues of human sexuality and sexually marked behaviors in the context of the concentration camps, and their descriptions in the memoirs of the survivors. Using notions and concepts of the so called "black American feminism" the author (referring extensively to books by Stanisław Grzesiuk and Zofia Romanowiczowa shows how in the concentration camp the human body became the only space of a relative privacy of the prisoner. At the same time the body becomes a territory on which all - both biological and socially constructed - human fates cross.

  4. Landownership Concentration and the Expansion of Education

    DEFF Research Database (Denmark)

    Cinnirella, Francesco; Hornung, Erik

    2016-01-01

    We study the relationship between large landownership concentration and the expansion of mass education in nineteenth-century Prussia. Cross-sectional estimates show a negative association between landownership concentration and enrollment rates. Fixed-effects panel estimates indicate that regions...... with an initially stronger landownership concentration exhibit increasing enrollment rates. This relationship is not driven by differences in the supply of schooling. We argue that the implementation of agricultural reforms including the stepwise abolition of serfdom is an important driver of the change...

  5. Indoor radon concentration forecasting in South Tyrol.

    Science.gov (United States)

    Verdi, L; Weber, A; Stoppa, G

    2004-01-01

    In this paper a modern statistical technique of multivariate analysis is applied to an indoor radon concentration data base. Several parameters are more or less significant in determining the radon concentration inside a building. The elaboration of the information available on South Tyrol makes it possible both to identify the statistically significant variables and to build up a statistical model that allows us to forecast the radon concentration in dwellings, when the values of the same variables involved are given. The results confirm the complexity of the phenomenon.

  6. High-dimensional entanglement concentration of twisted photon pairs High-dimensional entanglement concentration

    Science.gov (United States)

    Chen, L. X.; Wu, Q. P.

    2012-10-01

    Recently, Dada et al. reported on the experimental entanglement concentration and violation of generalized Bell inequalities with orbital angular momentum (OAM) [Nat. Phys. 7, 677 (2011)]. Here we demonstrate that the high-dimensional entanglement concentration can be performed in arbitrary OAM subspaces with selectivity. Instead of violating the generalized Bell inequalities, the working principle of present entanglement concentration is visualized by the biphoton OAM Klyshko picture, and its good performance is confirmed and quantified through the experimental Shannon dimensionalities after concentration.

  7. ISLSCP II Globalview: Atmospheric CO2 Concentrations

    Data.gov (United States)

    National Aeronautics and Space Administration — The GlobalView Carbon Dioxide (CO2) data product contains synchronized and smoothed time series of atmospheric CO2 concentrations at selected sites that were created...

  8. Seasonal Variation in Human Salivary Cortisol Concentration

    DEFF Research Database (Denmark)

    Persson, Roger; Garde, Anne Helene; Hansen, Åse Marie

    2008-01-01

    Measurement of cortisol concentration can contribute important information about an individual's ability to adjust to various environmental demands of both physical and psychosocial origin. However, one uncertainty that affects the possibilities of correctly interpreting and designing field studi...

  9. Characterisation and concentration profile of aluminium during ...

    African Journals Online (AJOL)

    Characterisation and concentration profile of aluminium during drinking-water treatment. ... at a surface water treatment plant (Buffalo Pound Water Treatment Plant ... Seasonal evaluations of Al at BPWTP showed that raw lake water total ...

  10. Bioaerosol concentrations - Figure 3 and Figure 4

    Data.gov (United States)

    U.S. Environmental Protection Agency — Bioaerosol concentrations. This dataset is associated with the following publication: Chattopadhyay, S., S. Perkins, M. Shaw, and T. Nichols. Evaluation of Exposure...

  11. Music in Concentration Camps 1933-1945

    National Research Council Canada - National Science Library

    Fackler, Guido

    2007-01-01

    The author addresses the topic of musical activities in the German concentration camps from 1933 to 1945, focusing on those camps that the Nazi regime started to erect just a few weeks after Hitler's assumption of power...

  12. Side Effects - Memory or Concentration Problems

    Science.gov (United States)

    Cancer treatments, such as chemo, may cause difficulty thinking, concentrating, or other cognitive problems. Learn about steps people with cancer can take to manage these side effects. See a list of helpful questions for families to ask the doctor.

  13. Concentrated sunlight for organic solar cells

    DEFF Research Database (Denmark)

    Tromholt, Thomas

    2010-01-01

    Concentrated sunlight provides a novel approach to the study of the physical and electrical parameters of organic solar cells. The study of performance of organic solar cells at high solar concentrations provides insight into the physics, which cannot be studied with conventional solar simulators....... A high solar intensity study of inverted P3HT:PCBM solar cells is presented. Performance peak positions were found to be in the range of 1-5 suns, with smaller cells peaking at higher solar concentrations. Additionally, concentrated sunlight is demonstrated as a practical tool for accelerated stability...... studies of polymers for organic solar cells. Degradation was monitored by the evolution of the UV-vis absorption over time. Varying the solar intensity from 1 to 200 suns, the degradation rates were increased by more than a factor of 100 relative to degradation at 1 simulated sun. 5 different polymers...

  14. Photovoltaic concentrator using a holographic optical element.

    Science.gov (United States)

    Zhang, Y W; Ih, C S; Yan, H F; Chang, M J

    1988-08-15

    A photovoltaic concentrator is proposed that uses equatorial tracking (the rotation axis of a concentrator points to the North Star), so that the change of the sun's altitude angle is minimized. The solar concentrator consists of a Fresnel lens (objective), a holographic optical element made on photoresist with 90% diffraction efficiency, and a field lens (making the sunlight come from different fields of view uniformly falling on the solar cell). The accuracy of the original 2-D tracking is reduced several orders over previous methods; however, it may be that only 1-D tracking is needed. A theoretical analysis and a study model have been made, and a reasonable concentration ratio has been obtained. Therefore, it can be expected that the cost will be much lower than an accurate 2-D tracking system.

  15. [Nitrate concentrations in tap water in Spain].

    Science.gov (United States)

    Vitoria, Isidro; Maraver, Francisco; Sánchez-Valverde, Félix; Armijo, Francisco

    2015-01-01

    To determine nitrate concentrations in drinking water in a sample of Spanish cities. We used ion chromatography to analyze the nitrate concentrations of public drinking water in 108 Spanish municipalities with more than 50,000 inhabitants (supplying 21,290,707 potential individuals). The samples were collected between January and April 2012. The total number of samples tested was 324. The median nitrate concentration was 3.47 mg/L (range: 0.38-66.76; interquartile range: 4.51). The water from 94% of the municipalities contained less than 15 mg/L. The concentration was higher than 25mg/L in only 3 municipalities and was greater than 50mg/L in one. Nitrate levels in most public drinking water supplies in municipalities inhabited by almost half of the Spanish population are below 15 mg/L. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  16. Inflammation Is Associated with Voriconazole Trough Concentrations

    NARCIS (Netherlands)

    van Wanrooy, Marjolijn J. P.; Span, Lambert F. R.; Rodgers, Michael G. G.; van den Heuvel, Edwin R.; Uges, Donald R. A.; van der Werf, Tjip S.; Kosterink, Jos G. W.; Alffenaar, Jan-Willem C.

    2014-01-01

    Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between

  17. Ownership Concentration, Top Management and Board Compensation

    Directory of Open Access Journals (Sweden)

    Marcos Barbosa Pinto

    2013-05-01

    Full Text Available The degree of ownership concentration may influence executive and board compensation (Bebchuk & Fried, 2003. This article analyzes this relationship. Detailed information about top management and board compensation became available starting in 2010 through new Securities Commission filings. Linear regression models applied to a sample of 315 Brazilian companies traded on the national exchange indicate a negative and statistically significant economic correlation between executive compensation and the degree of ownership concentration. Ceteris paribus, companies with a lower degree of ownership concentration pay higher compensation to top executives. Family controlled companies pay more to their chief executive, but not to the managerial team as a whole, and the compensation of directors increases with a greater proportion of control group members or their relatives on the board. There was support for the Managerial Power Hypothesis in companies with a lower degree of ownership concentration and for the extraction of private benefits in companies where it is greater.

  18. Arctic and Southern Ocean Sea Ice Concentrations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Monthly sea ice concentration for Arctic (1901 to 1995) and Southern oceans (1973 to 1990) were digitized on a standard 1-degree grid (cylindrical projection) to...

  19. Ceftibuten concentrations in human tonsillar tissue.

    Science.gov (United States)

    Scaglione, F; Pintucci, J P; Demartini, G; Dugnani, S

    1996-12-01

    In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 +/- 2.7 and 0.3 +/- mg/g, respectively. Concurrent mean serum concentrations were 7.42 +/- 1.66 and 0.15 +/- 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis.

  20. Certification of the concentrating solar collector

    Science.gov (United States)

    1980-01-01

    Report describes procedures and results of extensive testing of concentrating solar collector performed for certification of systems compliance with government performance standards. Test includes operational, electrical, mechanical, and thermal checks, as well as structural integrity.