PIGWEED (AMARANTHUS HYBRIDUS L.)
African Journals Online (AJOL)
I00S 75/25 50/50 25/75 ЮОР/В. S/B/P proportion (%). Figure 1. Relative growth rate (RGR) of soybean (S), blackjack (B) and pigweed (P) grown in mixtures 45-. 60 days after emergence. TABLE 2. The number of branches in soybean (S), blackjack (B) and pigweed (P) grown in mixtures at successive harvests (DPE). Crop/ ...
Activity of acetolactate synthase (ALS) of redroot pigweed in relation ...
African Journals Online (AJOL)
Values of resistance index were calculated in relation to the referent population collected from the ruderal sites. Based upon the results of biological studies in the redroot pigweed plants from the locality of Krivaja, the presence of resistance was established. Immunological tests confirmed the results of biological assays ...
Influence of redroot pigweed (Amaranthus retroflexus) density and ...
African Journals Online (AJOL)
ajl yemi
2011-12-26
Dec 26, 2011 ... soybean and snap beans (Knezevic et al., 1999; Aguyoh and Masiunas, 2003; Bensch et al., 2003; Culpepper et al., 2006). However, information related to the density dependent effects of redroot pigweed on peanut yield losses are lack. Those losses would be even more important for short plants such as ...
Ma, Xiaoyan; Wu, Hanwen; Jiang, Weili; Ma, Yajie; Ma, Yan
2015-01-01
Redroot pigweed is one of the injurious agricultural weeds on a worldwide basis. Understanding of its interference impact in crop field will provide useful information for weed control programs. The effects of redroot pigweed on cotton at densities of 0, 0.125, 0.25, 0.5, 1, 2, 4, and 8 plants m(-1) of row were evaluated in field experiments conducted in 2013 and 2014 at Institute of Cotton Research, CAAS in China. Redroot pigweed remained taller and thicker than cotton and heavily shaded cotton throughout the growing season. Both cotton height and stem diameter reduced with increasing redroot pigweed density. Moreover, the interference of redroot pigweed resulted in a delay in cotton maturity especially at the densities of 1 to 8 weed plants m(-1) of row, and cotton boll weight and seed numbers per boll were reduced. The relationship between redroot pigweed density and seed cotton yield was described by the hyperbolic decay regression model, which estimated that a density of 0.20-0.33 weed plant m(-1) of row would result in a 50% seed cotton yield loss from the maximum yield. Redroot pigweed seed production per plant or per square meter was indicated by logarithmic response. At a density of 1 plant m(-1) of cotton row, redroot pigweed produced about 626,000 seeds m(-2). Intraspecific competition resulted in density-dependent effects on weed biomass per plant, a range of 430-2,250 g dry weight by harvest. Redroot pigweed biomass ha(-1) tended to increase with increasing weed density as indicated by a logarithmic response. Fiber quality was not significantly influenced by weed density when analyzed over two years; however, the fiber length uniformity and micronaire were adversely affected at density of 1 weed plant m(-1) of row in 2014. The adverse impact of redroot pigweed on cotton growth and development identified in this study has indicated the need of effective redroot pigweed management.
Density and dry weight of pigweed by various weed control methods ...
African Journals Online (AJOL)
This study evaluates effects of various weeds control methods and nitrogen fertilizer resources on density and dry weight of pigweed and the performance of corn forage as factorial in full random block design with 3 repetitions in research farm of Ferdowsi Mashhad University in 2014. The test treatments include weed ...
Directory of Open Access Journals (Sweden)
naser jafarzadeh
2016-11-01
Full Text Available Introduction Growth analysis has been widely used in breeding programs to identify the important plant developmental phases and components related to higher yield under a particular set of environmental conditions. Castor bean (Ricinus communis L. is an important commercial crop. Castor oil based by products is used in manufacturing of several commercially important commodities like surfactants, coatings, greases, pharmaceuticals, cosmetics, polyesters, polymers, etc. Interference (Interactive effects among species on inter-species populations is one of the main issues on the eco-physiology of plant populations where weeds impose negative effects by approaching the plant to compete in light, water and nutrient elements availability and results in reduced growth and yield (Shinggu et al., 2011. Growth indices are useful for interpreting plant reactions to the crop and weed density. Various reasons have been attributed for the low productivity among the most important is weed competition (Radosevich, 1987. The aim of the present experiment was evaluating the interference effects of redroot pigweed on growth indices of castor bean in northwest of Iran. Materials and methods This experiment was conducted in Urmia, Iran (Agricultural Research of West Azarbayjan, Saatlo Station (37°44´18״ N Latitude and 45° 10´ 53״ E Longitude, at 1338 m above sea level in 2012. The soil of the experimental field was sandy - loam, with pH of 7.2. Competitive pattern of experiment was in two-factor based on a randomized complete block design (RCBD with three replications arranged in four castor plant densities (3, 4, 5 and 6 plants.m-2 and four redroot pigweed densities (0, 5, 10 and 15 plants.m-2. Redroot pigweed and castor seeds were simultaneously directly planted on the 22th May in 2012. Redroot pigweed plants were weeded at the times related to the treatments level. Irrigation and intercultural operations were performed whenever necessary. Plots were 3m×5m
Gieffers, J; Solbach, W; Maass, M
2001-01-01
Recovery of viable Chlamydia pneumoniae from atheromas of coronary heart diseases patients has initiated pilot studies to eradicate C. pneumoniae from vascular tissue by antibiotic treatment. To provide data for the selection of effective antibiotics, we investigated the in vitro activity of anti-chlamydial antibiotics to eliminate vascular strains of C. pneumoniae from coronary endothelial and smooth muscle cells, celltypes that are involved in the pathogenesis of atherosclerosis. The susceptibility of the obligate intracellular chlamydiae was studied in primary coronary endothelial cells, smooth muscle cells and immortalized epithelial cells. Minimal inhibitory concentrations (MICs) were determined for ofloxacin, levofloxacin, trovafloxacin, moxifloxacin, erythromycin, azithromycin, roxithromycin, rifapentin and rifampin. In vitro, rifampin was the most effective drug overall. Moxifloxacin and trovafloxacin were as effective as the macrolides of which roxithromycin was the most active one. Actively replicating C. pneumoniae can be eliminated in vitro from cell types, involved in the pathogenesis of atherosclerosis by various antibiotics. These data provide an experimental background for the selection of antibiotics in clinical eradication studies and will help to assess the potential success of prevention and eradication therapies.
Genetic Susceptibility to Dental Caries on Pit and Fissure and Smooth Surfaces
Shaffer, J.R.; Wang, X.; DeSensi, R.S.; Wendell, S.; Weyant, R.J.; Cuenco, K.T.; Crout, R.; McNeil, D.W.; Marazita, M.L.
2012-01-01
Carious lesions are distributed nonuniformly across tooth surfaces of the complete dentition, suggesting that the effects of risk factors may be surface-specific. Whether genes differentially affect caries risk across tooth surfaces is unknown. We investigated the role of genetics on two classes of tooth surfaces, pit and fissure surfaces (PFS) and smooth surfaces (SMS), in more than 2,600 subjects from 740 families. Participants were examined for surface-level evidence of dental caries, and caries scores for permanent and/or primary teeth were generated separately for PFS and SMS. Heritability estimates (h2, i.e. the proportion of trait variation due to genes) of PFS and SMS caries scores were obtained using likelihood methods. The genetic correlations between PFS and SMS caries scores were calculated to assess the degree to which traits covary due to common genetic effects. Overall, the heritability of caries scores was similar for PFS (h2 = 19–53%; p caries scores for both PFS and SMS in the primary dentition was greater than in the permanent dentition and total dentition. With one exception, the genetic correlation between PFS and SMS caries scores was not significantly different from 100%, indicating that (mostly) common genes are involved in the risk of caries for both surface types. Genetic correlation for the primary dentition dfs (decay + filled surfaces) was significantly less than 100% (p caries risk in PFS versus SMS in the primary dentition. PMID:22286298
Harrold, R L; Craig, D L; Nalewaja, J D; North, B B
1980-07-01
Pure green foxtail (Setaria viridis Beauv.), yellow foxtail (Setaria lutescens Hubb.), wild oats (Avena fatua L.), wild buckwehat (Polygonum convolvulus L.) and redroot pigweed (Amaranthus retroflexus L.) seeds were fed to growing male rats in two experiments. In the first experiment, green or yellow foxtail and wild oats seeds were found to be first-limiting in the amino acid lysine. Green or yellow foxtail seed supplemented with lysine produced satisfactory rat growth. Digestible energy (DE) values of lysine-supplemented diets were: 3.478, 3.068 and 2.696 kcal/g dry matter (DM) for green foxtail, yellow foxtail and wild oats, respectively. Protein digestibility values were 77.1, 68.6 and 54.2 for the respective diets. Wild oats were accepted poorly by the rats, even after lysine supplementation. In the second experiment, rats required approximately 7 days to adapt to voluntary consumption of an amino acid-supplemented wild buckwheat diet. Moderate weight gain of weanling male rats was obtained because of high consumption of the wild buckwheat diet, which had 2.206 kcal DE/g DM and 52.5% crude protein digestibility. In contrast, initial high acceptability of the redroot pigweed diet quickly declined. Digestibility values for the redroot pigweed diet were 2.884 kcal DE/g DM and 54.6% rude protein digestibility. The relationship between digestibility values obtained with rats and those obtained with swine is discussed.
KAHRAMANOĞLU, İbrahim; Uygur, F. Nezihi
2010-01-01
Minimum doses of metribuzin that provide satisfactory control (>90%) of redroot pigweed (Amaranthus retroflexus L.) and wild mustard (Sinapis arvensis L.), 2 troublesome weeds of potato crops planted in spring and autumn, respectively, were assessed. Greenhouse experiments were conducted using 100%, 80%, 60%, 40%, 20%, and 0% of the registered dose (525 g a.i. ha-1) of metribuzin applied to the weeds grown in plastic pots. Dry weight data from the experiments were subjected to nonlinea...
Directory of Open Access Journals (Sweden)
A.J Yanegh
2013-08-01
Full Text Available This study carried out in a factorial layout on completely randomaized block design with three replications, to evaluate the above- and below- ground competition between sesame (Sesamum indicum and pigweed (Amaranthus retroflexus, and their impacts on sesame yield and yield component. The experimental treatments were all combination of crop-weed competition (shoot competition, root competition and root-shoot competition and sesame plant densitys (1, 2 and 4 plant per pot. Plants were sown in plastic pots (24 cm diameter and 28 cm height in year 2010, at feild of Ferdowsi University of Mashhad. For study the shoot competition of sesame-pigweed, the roots were separated by plastic when the pots were filled with soil before sowing the seeds. Three weeks after emerging, shoots of plants were separated vertical barrier (30 x 70 cm for studing root competition. Results showed that competition treatments had a significant effect on seed weight per plant and yield components except 1000 seed weight. Among competition produced higher yield and yield components compared to othere treatments. However, sesame and pigweed biological weight in root-shoot competition was 2.6 and 13.7 respectively, that was higher than other competition treatments and was significant. Capsule number in main and sub branches, capsule number in plant, seed number in capsule and seed number in plant in complete competition treatment was 15, 2.58, 17.5, 43.7 and 693.89 respectively, that was higher than other treatments and differences among them was significant. Sesame density also had a significant effect on seed weight per plant and yield components. When low density were used (one plant, yield and yield components was more, therefore in one plant per pot density biological weight of sesame was 3.82 gr, and in higher densities the mentioned traits decreased significantly.
Sinha, Rajnikant
2014-01-01
This book offers an introduction to the theory of smooth manifolds, helping students to familiarize themselves with the tools they will need for mathematical research on smooth manifolds and differential geometry. The book primarily focuses on topics concerning differential manifolds, tangent spaces, multivariable differential calculus, topological properties of smooth manifolds, embedded submanifolds, Sard’s theorem and Whitney embedding theorem. It is clearly structured, amply illustrated and includes solved examples for all concepts discussed. Several difficult theorems have been broken into many lemmas and notes (equivalent to sub-lemmas) to enhance the readability of the book. Further, once a concept has been introduced, it reoccurs throughout the book to ensure comprehension. Rank theorem, a vital aspect of smooth manifolds theory, occurs in many manifestations, including rank theorem for Euclidean space and global rank theorem. Though primarily intended for graduate students of mathematics, the book ...
Directory of Open Access Journals (Sweden)
alireza barkhi
2009-06-01
Full Text Available An experiment was conducted in 2002-2003 using split-split plot arrangement based on Rondomised Compelete Block Design with three replications at Feiz Abad Agricultural Research Station of Qazvin, in order to study of planting patterns and corn densitis effect in competition with redroot pigweed. Main plots inclouded two planting pattern of corn (P1: single row and P2: double row, sub plots inclouded two corn densities (D1:7 and D2:10 plant/m2 and sub sub plots inclouded 4 weed densities (C1:0, C2:2, C3:6, C4:12 plant/m2. Sampling conducted in 2-weekly intervals and growth indices evaluated. Results indicated that with increasing of weed density CGR, TDW, LAI, number of seeds in row, grain and ear yield decreased but plant height increased. Also LAI, CGR, TDW, number of weed seed and seed,s weight of weed increased. By increasing in corn density LAI, CGR, TDW, ear and grain yield increased, but length and diameter of ear and number of seeds in row decreased. Also LAI and CGR of weed increased, but TDW was decreased. In double row planting pattern just CGR, LAI, TDW of corn were higher significantly than single row planting pattern. But single row planting of weed caused higher LAI, NAR, RGR, CGR and TDW of weed in comparison with double row planting pattern. In 2-way interaction, double row planting pattern and zero densities and 2 weeds/m2 had highest grain yield respectively. There were no significant differences for 3-way interactions but double row planting pattern 10 plant density of corn/m2 zero weed/ m2 had highest grain yield.
Günther, Felix
2017-03-15
Polyhedral surfaces are fundamental objects in architectural geometry and industrial design. Whereas closeness of a given mesh to a smooth reference surface and its suitability for numerical simulations were already studied extensively, the aim of our work is to find and to discuss suitable assessments of smoothness of polyhedral surfaces that only take the geometry of the polyhedral surface itself into account. Motivated by analogies to classical differential geometry, we propose a theory of smoothness of polyhedral surfaces including suitable notions of normal vectors, tangent planes, asymptotic directions, and parabolic curves that are invariant under projective transformations. It is remarkable that seemingly mild conditions significantly limit the shapes of faces of a smooth polyhedral surface. Besides being of theoretical interest, we believe that smoothness of polyhedral surfaces is of interest in the architectural context, where vertices and edges of polyhedral surfaces are highly visible.
J.C. de Jongste (Johan)
1987-01-01
textabstractThe function of airway smooth muscle in normal subjects is not evident. Possible physiological roles include maintenance of optimal regional ventilation/perfusion ratios, reduction of anatomic dead space, stabilisation of cartilaginous bronchi, defense against impurities and, less
Laplacians on smooth distributions
Kordyukov, Yu. A.
2017-10-01
Let M be a compact smooth manifold equipped with a positive smooth density μ and let H be a smooth distribution endowed with a fibrewise inner product g. We define the Laplacian Δ_H associated with (H,μ,g) and prove that it gives rise to an unbounded self-adjoint operator in L^2(M,μ). Then, assuming that H generates a singular foliation \\mathscr F, we prove that, for any function \\varphi in the Schwartz space \\mathscr S( R), the operator \\varphi(Δ_H) is a smoothing operator in the scale of longitudinal Sobolev spaces associated with \\mathscr F. The proofs are based on pseudodifferential calculus on singular foliations, which was developed by Androulidakis and Skandalis, and on subelliptic estimates for Δ_H. Bibliography: 35 titles.
Energy Technology Data Exchange (ETDEWEB)
2017-12-12
smoothG is a collection of parallel C++ classes/functions that algebraically constructs reduced models of different resolutions from a given high-fidelity graph model. In addition, smoothG also provides efficient linear solvers for the reduced models. Other than pure graph problem, the software finds its application in subsurface flow and power grid simulations in which graph Laplacians are found
Jongste, Johan
1987-01-01
textabstractThe function of airway smooth muscle in normal subjects is not evident. Possible physiological roles include maintenance of optimal regional ventilation/perfusion ratios, reduction of anatomic dead space, stabilisation of cartilaginous bronchi, defense against impurities and, less likely, squeezing mucus out of mucous glands and pulling open the alveoli next to the airways1 . Any role of airway smooth muscle is necessarily limited, because an important degree of contraction will l...
Indian Academy of Sciences (India)
Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Proceedings – Mathematical Sciences; Volume 125; Issue 2. Smoothness of limit functors. Benedictus Margaux. Volume 125 Issue 2 May 2015 pp 161-165 ...
Smoothed Particle Hydrodynamic Simulator
Energy Technology Data Exchange (ETDEWEB)
2016-10-05
This code is a highly modular framework for developing smoothed particle hydrodynamic (SPH) simulations running on parallel platforms. The compartmentalization of the code allows for rapid development of new SPH applications and modifications of existing algorithms. The compartmentalization also allows changes in one part of the code used by many applications to instantly be made available to all applications.
Generalizing smooth transition autoregressions
DEFF Research Database (Denmark)
Chini, Emilio Zanetti
We introduce a variant of the smooth transition autoregression - the GSTAR model - capable to parametrize the asymmetry in the tails of the transition equation by using a particular generalization of the logistic function. A General-to-Specific modelling strategy is discussed in detail...
Indian Academy of Sciences (India)
Indian Acad. Sci. (Math. Sci.) Vol. 125, No. 2, May 2015, pp. 161–165. c Indian Academy of Sciences. Smoothness of limit functors. BENEDICTUS MARGAUX. Laboratoire de Recherche “Princess .... On the same vein, the coaction cλ : A[X] → A[X][t±1] is defined 'at a finite level', that is, there exists α1 ≥ α0 and a Aα1 ...
Dabrowska, Dorota M.
1997-01-01
Nonparametric regression was shown by Beran and McKeague and Utikal to provide a flexible method for analysis of censored failure times and more general counting processes models in the presence of covariates. We discuss application of kernel smoothing towards estimation in a generalized Cox regression model with baseline intensity dependent on a covariate. Under regularity conditions we show that estimates of the regression parameters are asymptotically normal at rate root-n, and we also dis...
Smoothly Varying Bright Blazars
Van Alfen, Nicholas; Hindman, Lauren; Moody, Joseph Ward; Biancardi, Rochelle; Whipple, Parkes; Gaunt, Caleb
2018-01-01
It is becoming increasingly apparent that blazar light can vary sinusoidally with periods of hundreds of days to tens of years. Such behavior is expected of, among other things, jets coming from binary black holes. To look for general variability in lesser-known blazars and AGN, in 2015-2016 we monitored 182 objects with Johnson V-band magnitudes reported as being < 16. In all, this campaign generated 22,000 frames from 2,000 unique pointings. We find that approximately one dozen of these objects show evidence of smooth variability consistent with sinusoidal periods. We report on the entire survey sample, highlighting those that show sinusoidal variations.
Classification of smooth Fano polytopes
DEFF Research Database (Denmark)
Øbro, Mikkel
A simplicial lattice polytope containing the origin in the interior is called a smooth Fano polytope, if the vertices of every facet is a basis of the lattice. The study of smooth Fano polytopes is motivated by their connection to toric varieties. The thesis concerns the classification of smooth...... Fano polytopes up to isomorphism. A smooth Fano -polytope can have at most vertices. In case of vertices an explicit classification is known. The thesis contains the classification in case of vertices. Classifications of smooth Fano -polytopes for fixed exist only for . In the thesis an algorithm...... for the classification of smooth Fano -polytopes for any given is presented. The algorithm has been implemented and used to obtain the complete classification for ....
Dynamics of smooth muscle contraction
G.A. van Kloeveringe (Gommert)
1997-01-01
textabstractSmooth muscle can economically maintain tonus for a long time and in many organs, its purpose is to maintain organ dimensions. It is however relatively slow and also inefficient as far as mechanical work is concerned. Smooth muscle is found in the majority of organs in the human body. It
Smooth analysis in Banach spaces
Hájek, Petr
2014-01-01
This bookis aboutthe subject of higher smoothness in separable real Banach spaces.It brings together several angles of view on polynomials, both in finite and infinite setting.Also a rather thorough and systematic view of the more recent results, and the authors work is given. The book revolves around two main broad questions: What is the best smoothness of a given Banach space, and its structural consequences? How large is a supply of smooth functions in the sense of approximating continuous functions in the uniform topology, i.e. how does the Stone-Weierstrass theorem generalize into in
Smooth Sailing with Contract Services.
Fickes, Michael
2001-01-01
Discusses how to make the contract services relationship work smoothly for educational facilities. Covers topics of food, child care, and transportation services, along with a brief explanation of the benefits of outsourcing on-campus amenities. (GR)
on gastro intestinal smooth muscle
African Journals Online (AJOL)
USER
, Kaduna State. Correspondence author: am.huguma@yahoo.com. ABSTRACT. The effects of the aqueous leaf extract of Combretum micranthum were studied on gastro intestinal smooth muscle of rodents. The extract was screened using ...
Aging and gastrointestinal smooth muscle.
Bitar, Khalil N; Patil, Suresh B
2004-12-01
The present review is an attempt to put into perspective the available information on the putative changes in cellular mechanisms of the contractile properties of the aging gastrointestinal (GI) smooth muscle. Information on smooth muscle of the GI tract is scanty. Smooth muscle cells from old rats (32 months old) exhibit limited cell length distribution and diminished contractility. The observed reduced contractile response may be due to the effect of aging on signal transduction pathways, especially an inhibition of the tyrosine kinase-Src kinase pathway, a reduced activation of the PKCalpha pathway, a reduced association of contractile proteins (HSP27-tropomyosin, HSP27-actin, and actin-myosin). Levels of HSP27-phosphorylation are also reduced compared to adult rats. Regulation of GI motility is a complex mechanism of signal transduction and interaction of signaling and contractile proteins. It is suggested that further studies to elucidate the role of HSP27 in aging smooth muscle of the GI tract are needed.
Smooth Nonparametric Bernstein Vine Copulas
Weiß, Gregor; Scheffer, Marcus
2012-01-01
We propose to use nonparametric Bernstein copulas as bivariate pair-copulas in high-dimensional vine models. The resulting smooth and nonparametric vine copulas completely obviate the error-prone need for choosing the pair-copulas from parametric copula families. By means of a simulation study and an empirical analysis of financial market data, we show that our proposed smooth nonparametric vine copula model is superior to competing parametric vine models calibrated via Akaike's Information C...
Radar data smoothing filter study
White, J. V.
1984-01-01
The accuracy of the current Wallops Flight Facility (WFF) data smoothing techniques for a variety of radars and payloads is examined. Alternative data reduction techniques are given and recommendations are made for improving radar data processing at WFF. A data adaptive algorithm, based on Kalman filtering and smoothing techniques, is also developed for estimating payload trajectories above the atmosphere from noisy time varying radar data. This algorithm is tested and verified using radar tracking data from WFF.
Exotic smoothness and quantum gravity
Energy Technology Data Exchange (ETDEWEB)
Asselmeyer-Maluga, T, E-mail: torsten.asselmeyer-maluga@dlr.d [German Aerospace Center, Berlin, Germany and Loyola University, New Orleans, LA (United States)
2010-08-21
Since the first work on exotic smoothness in physics, it was folklore to assume a direct influence of exotic smoothness to quantum gravity. Thus, the negative result of Duston (2009 arXiv:0911.4068) was a surprise. A closer look into the semi-classical approach uncovered the implicit assumption of a close connection between geometry and smoothness structure. But both structures, geometry and smoothness, are independent of each other. In this paper we calculate the 'smoothness structure' part of the path integral in quantum gravity assuming that the 'sum over geometries' is already given. For that purpose we use the knot surgery of Fintushel and Stern applied to the class E(n) of elliptic surfaces. We mainly focus our attention to the K3 surfaces E(2). Then we assume that every exotic smoothness structure of the K3 surface can be generated by knot or link surgery in the manner of Fintushel and Stern. The results are applied to the calculation of expectation values. Here we discuss the two observables, volume and Wilson loop, for the construction of an exotic 4-manifold using the knot 5{sub 2} and the Whitehead link Wh. By using Mostow rigidity, we obtain a topological contribution to the expectation value of the volume. Furthermore, we obtain a justification of area quantization.
2000-01-01
The book provides a self-contained introduction to the mathematical theory of non-smooth dynamical problems, as they frequently arise from mechanical systems with friction and/or impacts. It is aimed at applied mathematicians, engineers, and applied scientists in general who wish to learn the subject.
Income smoothing by Dutch hospitals
Boterenbrood, D.R.
2014-01-01
Research indicates that hospitals manage their earnings. However, these findings might be influenced by methodological issues. In this study, I exploit specific features of Dutch hospitals to study income smoothing while limiting these methodological issues. The managers of Dutch hospitals have the
Panel Smooth Transition Regression Models
DEFF Research Database (Denmark)
González, Andrés; Terasvirta, Timo; Dijk, Dick van
We introduce the panel smooth transition regression model. This new model is intended for characterizing heterogeneous panels, allowing the regression coefficients to vary both across individuals and over time. Specifically, heterogeneity is allowed for by assuming that these coefficients are bou...
Smooth paths of conditional expectations
Andruchow, Esteban; Larotonda, Gabriel
2010-01-01
Let A be a von Neumann algebra with a finite trace $\\tau$, represented in $H=L^2(A,\\tau)$, and let $B_t\\subset A$ be sub-algebras, for $t$ in an interval $I$. Let $E_t:A\\to B_t$ be the unique $\\tau$-preserving conditional expectation. We say that the path $t\\mapsto E_t$ is smooth if for every $a\\in A$ and $v \\in H$, the map $$ I\
Beam smoothing and temporal effects
Energy Technology Data Exchange (ETDEWEB)
Hora, H.; Aydin, M.; Eliezer, S.; Goldsworthy, M.P.; Min, G.; Gahatak, A.K.; Lalousis, P.; Stening, R.J.; Szichman, H. [University of Technology, Sydney, NSW (Australia); Boreham, B.W. [Queensland Inst. of Tech., Gardens Point, QLD (Australia). Dept. of Physics; Luther-Davies, B.; Baldwin, K.G.H.; Rode, A.V. [Australian National Univ., Canberra, ACT (Australia)
1995-05-01
Until recently, and in spite of the introduction of smoothing methods, direct drive laser fusion received lots of setbacks from experiments, this being due to nonlinear and anomalous phenomena. This report deals with a method of analysis which, as self-generated von-Laue gratings, preventing the propagation of laser radiation through the outermost plasma corona, and preventing energy deposition. (TEC). 36 refs., 5 figs.
When does the H∞ fixed-lag smoothing saturate for finite smoothing lag
Mirkin, Leonid; Meinsma, Gjerrit
2004-01-01
A notable difference between the H∞ smoothing is that the achievable performance in the latter problem might "saturate" as the function of the smoothing lag in the sense that there might exist a finite smoothing lag for which the achievable performance level is the same as for the infinite smoothing
s-SMOOTH: Sparsity and Smoothness Enhanced EEG Brain Tomography
Directory of Open Access Journals (Sweden)
Ying Li
2016-11-01
Full Text Available EEG source imaging enables us to reconstruct current density in the brain from the electrical measurements with excellent temporal resolution (~ms. The corresponding EEG inverse problem is an ill-posed one that has infinitely many solutions. This is due to the fact that the number of EEG sensors is usually much smaller than that of the potential dipole locations, as well as noise contamination in the recorded signals. To obtain a unique solution, regularizations can be incorporated to impose additional constraints on the solution. An appropriate choice of regularization is critically important for the reconstruction accuracy of the brain image. In this paper, we propose a novel Sparsity and SMOOthness enhanced brain TomograpHy (s-SMOOTH method to improve the reconstruction accuracy by integrating two recently proposed regularization techniques: Total Generalized Variation (TGV regularization and l_(1-2 regularization. TGV is able to preserve the source edge and recover the spatial distribution of the source intensity with high accuracy. Compared to the relevant total variation (TV regularization, TGV enhances the smoothness of the image and reduces staircasing artifacts. The traditional TGV defined on a 2D image has been widely used in image processing field. In order to handle 3D EEG source images, we propose a voxel-based TGV (vTGV regularization that extends the definition of second-order TGV from 2D planar image to 3D irregular surfaces such as cortex surface. In addition, the l_(1-2 regularization is utilized to promote sparsity on the current density itself. We demonstrate that l_(1-2 regularization is able to enhance sparsity and accelerate computations than l_1 regularization. The proposed model is solved by an efficient and robust algorithm based on the difference of convex functions algorithm (DCA and the alternating direction method of multipliers (ADMM. Numerical experiments using synthetic data demonstrate the advantages of the
s-SMOOTH: Sparsity and Smoothness Enhanced EEG Brain Tomography.
Li, Ying; Qin, Jing; Hsin, Yue-Loong; Osher, Stanley; Liu, Wentai
2016-01-01
EEG source imaging enables us to reconstruct current density in the brain from the electrical measurements with excellent temporal resolution (~ ms). The corresponding EEG inverse problem is an ill-posed one that has infinitely many solutions. This is due to the fact that the number of EEG sensors is usually much smaller than that of the potential dipole locations, as well as noise contamination in the recorded signals. To obtain a unique solution, regularizations can be incorporated to impose additional constraints on the solution. An appropriate choice of regularization is critically important for the reconstruction accuracy of a brain image. In this paper, we propose a novel Sparsity and SMOOthness enhanced brain TomograpHy (s-SMOOTH) method to improve the reconstruction accuracy by integrating two recently proposed regularization techniques: Total Generalized Variation (TGV) regularization and ℓ1-2 regularization. TGV is able to preserve the source edge and recover the spatial distribution of the source intensity with high accuracy. Compared to the relevant total variation (TV) regularization, TGV enhances the smoothness of the image and reduces staircasing artifacts. The traditional TGV defined on a 2D image has been widely used in the image processing field. In order to handle 3D EEG source images, we propose a voxel-based Total Generalized Variation (vTGV) regularization that extends the definition of second-order TGV from 2D planar images to 3D irregular surfaces such as cortex surface. In addition, the ℓ1-2 regularization is utilized to promote sparsity on the current density itself. We demonstrate that ℓ1-2 regularization is able to enhance sparsity and accelerate computations than ℓ1 regularization. The proposed model is solved by an efficient and robust algorithm based on the difference of convex functions algorithm (DCA) and the alternating direction method of multipliers (ADMM). Numerical experiments using synthetic data demonstrate the
Smooth Adaptation by Sigmoid Shrinkage
Directory of Open Access Journals (Sweden)
Atto AbdourrahmaneM
2009-01-01
Full Text Available This paper addresses the properties of a subclass of sigmoid-based shrinkage functions: the non zeroforcing smooth sigmoid-based shrinkage functions or SigShrink functions. It provides a SURE optimization for the parameters of the SigShrink functions. The optimization is performed on an unbiased estimation risk obtained by using the functions of this subclass. The SURE SigShrink performance measurements are compared to those of the SURELET (SURE linear expansion of thresholds parameterization. It is shown that the SURE SigShrink performs well in comparison to the SURELET parameterization. The relevance of SigShrink is the physical meaning and the flexibility of its parameters. The SigShrink functions performweak attenuation of data with large amplitudes and stronger attenuation of data with small amplitudes, the shrinkage process introducing little variability among data with close amplitudes. In the wavelet domain, SigShrink is particularly suitable for reducing noise without impacting significantly the signal to recover. A remarkable property for this class of sigmoid-based functions is the invertibility of its elements. This propertymakes it possible to smoothly tune contrast (enhancement, reduction.
Pioline, Boris
2015-01-01
In $D=4,N=2$ theories on $R^{3,1}$, the index receives contributions not only from single-particle BPS states, counted by the BPS indices, but also from multi-particle states made of BPS constituents. In a recent work [arXiv:1406.2360], a general formula expressing the index in terms of the BPS indices was proposed, which is smooth across walls of marginal stability and reproduces the expected single-particle contributions. In this note, I analyze the two-particle contributions predicted by this formula, and show agreement with the spectral asymmetry of the continuum of scattering states in the supersymmetric quantum mechanics of two non-relativistic, mutually non-local dyons. This provides a physical justification for the error function profile used in the mathematics literature on indefinite theta series, and in the physics literature on black hole partition functions.
Smooth ergodic theory for endomorphisms
Qian, Min; Zhu, Shu
2009-01-01
This volume presents a general smooth ergodic theory for deterministic dynamical systems generated by non-invertible endomorphisms, mainly concerning the relations between entropy, Lyapunov exponents and dimensions. The authors make extensive use of the combination of the inverse limit space technique and the techniques developed to tackle random dynamical systems. The most interesting results in this book are (1) the equivalence between the SRB property and Pesin’s entropy formula; (2) the generalized Ledrappier-Young entropy formula; (3) exact-dimensionality for weakly hyperbolic diffeomorphisms and for expanding maps. The proof of the exact-dimensionality for weakly hyperbolic diffeomorphisms seems more accessible than that of Barreira et al. It also inspires the authors to argue to what extent the famous Eckmann-Ruelle conjecture and many other classical results for diffeomorphisms and for flows hold true. After a careful reading of the book, one can systematically learn the Pesin theory for endomorphis...
Autoregressive smoothing of GOMOS transmittances
Fussen, D.; Vanhellemont, F.; Bingen, C.; Kyrölä, B.; Tamminen, J.; Sofieva, V.; Hassinen, S.; Seppälä, A.; Verronen, P. T.; Bertaux, J. L.; Hauchecorne, A.; Dalaudier, F.; d'Andon, O. Fanton; Barrot, G.; Mangin, A.; Theodore, B.; Guirlet, M.; Renard, J. B.; Fraisse, R.; Snoeij, P.; Koopman, R.; Saavedra, L.
GOMOS is a stellar occultation instrument onboard ENVISAT. It has already measured several hundreds of thousands occultations since March 2002. In some circumstances, the obliqueness of the star setting causes the remote sounding of possible horizontal turbulence that cannot be adequately corrected by using the fast photometer signals, leading to the presence of residual scintillation in the atmospheric transmittance. We investigate the mechanism that produces this spurious signal that may cause the retrieval of wavy constituent profiles. A special algorithm of vertical autoregressive smoothing (VAS) is proposed that takes into account the physical correlation between adjacent measurements at different tangent altitudes. A regularization parameter of the method may be optimized on basis of the minimal correlation between the residuals as prescribed by the Durbin-Watson statistics. The improvements obtained in the retrieval of both O 3 and NO 2 number density profiles is presented and discussed with respect to the results of the official data processing model.
Properties of the extremal infinite smooth words
Directory of Open Access Journals (Sweden)
Srecko Brlek
2007-05-01
Full Text Available Smooth words are connected to the Kolakoski sequence. We construct the maximal and the minimal infinite smooth words, with respect to the lexicographical order. The naive algorithm generating them is improved by using a reduction of the De Bruijn graph of their factors. We also study their Lyndon factorizations. Finally, we show that the minimal smooth word over the alphabet {1,3} belongs to the orbit of the Fibonacci word.
Smoothed analysis of complex conic condition numbers
Buergisser, Peter; Cucker, Felipe; Lotz, Martin
2006-01-01
Smoothed analysis of complexity bounds and condition numbers has been done, so far, on a case by case basis. In this paper we consider a reasonably large class of condition numbers for problems over the complex numbers and we obtain smoothed analysis estimates for elements in this class depending only on geometric invariants of the corresponding sets of ill-posed inputs. These estimates are for a version of smoothed analysis proposed in this paper which, to the best of our knowledge, appears ...
Smooth horizons and quantum ripples
Golovnev, Alexey
2014-01-01
Black Holes are unique objects which allow for meaningful theoretical studies of strong gravity and even quantum gravity effects. An infalling and a distant observer would have very different views on the structure of the world. However, a careful analysis has shown that it entails no genuine contradictions for physics, and the paradigm of observer complementarity has been coined. Recently this picture was put into doubt. In particular, it was argued that in old Black Holes a firewall must form in order to protect the basic principles of quantum mechanics. This AMPS paradox has already been discussed in a vast number of papers with different attitudes and conclusions. Here we want to argue that a possible source of confusion is neglection of quantum gravity effects. Contrary to widespread perception, it does not necessarily mean that effective field theory is inapplicable in rather smooth neighbourhoods of large Black Hole horizons. The real offender might be an attempt to consistently use it over the huge di...
Local Transfer Coefficient, Smooth Channel
Directory of Open Access Journals (Sweden)
R. T. Kukreja
1998-01-01
Full Text Available Naphthalene sublimation technique and the heat/mass transfer analogy are used to determine the detailed local heat/mass transfer distributions on the leading and trailing walls of a twopass square channel with smooth walls that rotates about a perpendicular axis. Since the variation of density is small in the flow through the channel, buoyancy effect is negligible. Results show that, in both the stationary and rotating channel cases, very large spanwise variations of the mass transfer exist in he turn and in the region immediately downstream of the turn in the second straight pass. In the first straight pass, the rotation-induced Coriolis forces reduce the mass transfer on the leading wall and increase the mass transfer on the trailing wall. In the turn, rotation significantly increases the mass transfer on the leading wall, especially in the upstream half of the turn. Rotation also increases the mass transfer on the trailing wall, more in the downstream half of the turn than in the upstream half of the turn. Immediately downstream of the turn, rotation causes the mass transfer to be much higher on the trailing wall near the downstream corner of the tip of the inner wall than on the opposite leading wall. The mass transfer in the second pass is higher on the leading wall than on the trailing wall. A slower flow causes higher mass transfer enhancement in the turn on both the leading and trailing walls.
Smoothing a Piecewise-Smooth: An Example from Plankton Population Dynamics
DEFF Research Database (Denmark)
Piltz, Sofia Helena
2016-01-01
In this work we discuss a piecewise-smooth dynamical system inspired by plankton observations and constructed for one predator switching its diet between two different types of prey. We then discuss two smooth formulations of the piecewise-smooth model obtained by using a hyperbolic tangent...
The smoothness criterion as a trend diagnostic
P. Fogarty; Weber, N.C.
2006-01-01
The smoothness criterion is used in the design of symmetric moving average trend filters in time series and in graduation in actuarial studies. This measure of smoothness is used to motivate a diagnostic for determining the order of local polynomial trend.
Very smooth points of spaces of operators
Indian Academy of Sciences (India)
Home; Journals; Proceedings – Mathematical Sciences; Volume 113; Issue 1 ... We show that when the space of compact operators is an -ideal in the space of bounded operators, a very smooth operator attains its norm at a unique vector (up to a constant multiple) and ( ) is a very smooth point of the range space.
Smoothed Analysis of Local Search Algorithms
Manthey, Bodo; Dehne, Frank; Sack, Jörg-Rüdiger; Stege, Ulrike
2015-01-01
Smoothed analysis is a method for analyzing the performance of algorithms for which classical worst-case analysis fails to explain the performance observed in practice. Smoothed analysis has been applied to explain the performance of a variety of algorithms in the last years. One particular class of
Income and Consumption Smoothing among US States
DEFF Research Database (Denmark)
Sørensen, Bent; Yosha, Oved
within regions but not between regions. This suggests that capital markets transcend regional barriers while credit markets are regional in their nature. Smoothing within the club of rich states is accomplished mainly via capital markets whereas consumption smoothing is dominant within the club of poor...
The smoothness criterion as a trend diagnostic
Directory of Open Access Journals (Sweden)
2006-01-01
Full Text Available The smoothness criterion is used in the design of symmetric moving average trend filters in time series and in graduation in actuarial studies. This measure of smoothness is used to motivate a diagnostic for determining the order of local polynomial trend.
The smoothness criterion as a trend diagnostic
Directory of Open Access Journals (Sweden)
N. C. Weber
2006-02-01
Full Text Available The smoothness criterion is used in the design of symmetric moving average trend filters in time series and in graduation in actuarial studies. This measure of smoothness is used to motivate a diagnostic for determining the order of local polynomial trend.
Very smooth points of spaces of operators
Indian Academy of Sciences (India)
R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22
or Y has the compact metric approximation property (CMAP), then it is easy to see that K (X, Y ) ⊂ L(X, Y ) satisfies the above condition (see [R6]). Thus for a compact operator that is a very smooth point, directional derivatives exist in the direction of all bounded operators. Smooth points of operator spaces has been ...
Spline-Based Smoothing of Airfoil Curvatures
Li, W.; Krist, S.
2008-01-01
Constrained fitting for airfoil curvature smoothing (CFACS) is a splinebased method of interpolating airfoil surface coordinates (and, concomitantly, airfoil thicknesses) between specified discrete design points so as to obtain smoothing of surface-curvature profiles in addition to basic smoothing of surfaces. CFACS was developed in recognition of the fact that the performance of a transonic airfoil is directly related to both the curvature profile and the smoothness of the airfoil surface. Older methods of interpolation of airfoil surfaces involve various compromises between smoothing of surfaces and exact fitting of surfaces to specified discrete design points. While some of the older methods take curvature profiles into account, they nevertheless sometimes yield unfavorable results, including curvature oscillations near end points and substantial deviations from desired leading-edge shapes. In CFACS as in most of the older methods, one seeks a compromise between smoothing and exact fitting. Unlike in the older methods, the airfoil surface is modified as little as possible from its original specified form and, instead, is smoothed in such a way that the curvature profile becomes a smooth fit of the curvature profile of the original airfoil specification. CFACS involves a combination of rigorous mathematical modeling and knowledge-based heuristics. Rigorous mathematical formulation provides assurance of removal of undesirable curvature oscillations with minimum modification of the airfoil geometry. Knowledge-based heuristics bridge the gap between theory and designers best practices. In CFACS, one of the measures of the deviation of an airfoil surface from smoothness is the sum of squares of the jumps in the third derivatives of a cubicspline interpolation of the airfoil data. This measure is incorporated into a formulation for minimizing an overall deviation- from-smoothness measure of the airfoil data within a specified fitting error tolerance. CFACS has been
Lunar Smooth Plains Identification and Classification
Boyd, A. K.; Robinson, M. S.; Mahanti, P.; Lawrence, S. J.; Spudis, P.; Jolliff, B. L.
2012-12-01
Smooth plains are widespread on the Moon and have diverse origins. The maria comprise the majority of the smooth plains and are volcanic in origin. Highland smooth plains are patchy, and tend to fill large craters and basins; their origins have eluded unambiguous classification. Prior to the Apollo 16 mission, many workers thought that highland plains were volcanic, possibly more silicic than the maria. However, as the Apollo 16 samples are mostly impact breccias, the highland smooth plains were re-interpreted basin impact ejecta, most likely from the Imbrium and possibly Orientale basins. Conversely, some known non-mare volcanic units, such as the Apennine Bench Formation, contain light plains. These interpretations do not rule out alternate origins for a subset of highland smooth plains, including impact melt or volcanic origins (effusive or pyroclastic). We developed an algorithm to identify smooth plains using topographic parameters from the WAC Global Lunar Digital Terrain Model (DTM) (GLD100), sampled at 333 m/pixel. We classify the smooth plains using the Clementine UVVIS FeO map and photometrically corrected Lunar Reconnaissance Orbiter Camera (LROC) Wide Angle Camera (WAC) images. Terrain with slopes less than 2° (1 km baseline) and standard deviation of slope less than 0.75° (1 km x 1 km box, n=9) are defined as smooth plains. Highland smooth plains are distinguished from basaltic smooth plains using the following criteria: LROC WAC 643 nm normalized reflectance > 0.056, LROC WAC 321 nm / 415 nm ratio 0.77 is termed blue maria and a ratio ≤ 0.77 is termed red maria. The automatic classification was limited to the 87% of the Moon covered by photometrically normalized WAC data (60°S to 60°N). The differences between the maria and highland smooth plains deposits were more ambiguous in regions where the Clementine data had gores and albedo of the maria was elevated (i.e. Mare Frigoris and eastern Imbrium basin). For example, Schickard crater hosts a
Directory of Open Access Journals (Sweden)
Pedro J. Christoffoleti
1996-01-01
plants in a mixture of species, nor the importance of intra and inter-specific competition and niche diferentiation. Therefore, this research was developed aiming to describe the competitive interaction and competitive indexes between corn (Zea mays L. and pigweed (Amaranthus retroflexus L. plants. The methodology was a replacement series experiment with a total density of 400 plants/m2 and 5 proportions, besides the monoculture that varied from 50 to 800 plants/m2, conducted in a randomized completely block desing, four replications. The results were analyzed through conventional replacement series analysis, using reciprocal total and per plant yield. Corn was the superior competitor and the intra-specific competition was more important than the inter-specific for this species. The reverse was true for pigweed. Both species were competing for the same natural resources since the niche diferentiation index was lower than 1,0. The influence of density and proportion of species in a competition study is very important in the understanding of competitive interactions.
Progress in smooth particle hydrodynamics
Energy Technology Data Exchange (ETDEWEB)
Wingate, C.A.; Dilts, G.A.; Mandell, D.A.; Crotzer, L.A.; Knapp, C.E.
1998-07-01
Smooth Particle Hydrodynamics (SPH) is a meshless, Lagrangian numerical method for hydrodynamics calculations where calculational elements are fuzzy particles which move according to the hydrodynamic equations of motion. Each particle carries local values of density, temperature, pressure and other hydrodynamic parameters. A major advantage of SPH is that it is meshless, thus large deformation calculations can be easily done with no connectivity complications. Interface positions are known and there are no problems with advecting quantities through a mesh that typical Eulerian codes have. These underlying SPH features make fracture physics easy and natural and in fact, much of the applications work revolves around simulating fracture. Debris particles from impacts can be easily transported across large voids with SPH. While SPH has considerable promise, there are some problems inherent in the technique that have so far limited its usefulness. The most serious problem is the well known instability in tension leading to particle clumping and numerical fracture. Another problem is that the SPH interpolation is only correct when particles are uniformly spaced a half particle apart leading to incorrect strain rates, accelerations and other quantities for general particle distributions. SPH calculations are also sensitive to particle locations. The standard artificial viscosity treatment in SPH leads to spurious viscosity in shear flows. This paper will demonstrate solutions for these problems that they and others have been developing. The most promising is to replace the SPH interpolant with the moving least squares (MLS) interpolant invented by Lancaster and Salkauskas in 1981. SPH and MLS are closely related with MLS being essentially SPH with corrected particle volumes. When formulated correctly, JLS is conservative, stable in both compression and tension, does not have the SPH boundary problems and is not sensitive to particle placement. The other approach to
Sparse methods for Quantitative Susceptibility Mapping
Bilgic, Berkin; Chatnuntawech, Itthi; Langkammer, Christian; Setsompop, Kawin
2015-09-01
Quantitative Susceptibility Mapping (QSM) aims to estimate the tissue susceptibility distribution that gives rise to subtle changes in the main magnetic field, which are captured by the image phase in a gradient echo (GRE) experiment. The underlying susceptibility distribution is related to the acquired tissue phase through an ill-posed linear system. To facilitate its inversion, spatial regularization that imposes sparsity or smoothness assumptions can be employed. This paper focuses on efficient algorithms for regularized QSM reconstruction. Fast solvers that enforce sparsity under Total Variation (TV) and Total Generalized Variation (TGV) constraints are developed using Alternating Direction Method of Multipliers (ADMM). Through variable splitting that permits closed-form iterations, the computation efficiency of these solvers are dramatically improved. An alternative approach to improve the conditioning of the ill-posed inversion is to acquire multiple GRE volumes at different head orientations relative to the main magnetic field. The phase information from such multi-orientation acquisition can be combined to yield exquisite susceptibility maps and obviate the need for regularized reconstruction, albeit at the cost of increased data acquisition time.
Smoothing properties for Hirota-Satsuma systems
Directory of Open Access Journals (Sweden)
S. Jimenez
2011-08-01
Full Text Available We study local existence and smoothing properties for the initial value problem associated to Hirota-Satsuma systems that describes an interaction of two long waves with different dispersion relations.
Smooth surfaces from rational bilinear patches
Shi, Ling
2014-01-01
Smooth freeform skins from simple panels constitute a challenging topic arising in contemporary architecture. We contribute to this problem area by showing how to approximate a negatively curved surface by smoothly joined rational bilinear patches. The approximation problem is solved with help of a new computational approach to the hyperbolic nets of Huhnen-Venedey and Rörig and optimization algorithms based on it. We also discuss its limits which lie in the topology of the input surface. Finally, freeform deformations based on Darboux transformations are used to generate smooth surfaces from smoothly joined Darboux cyclide patches; in this way we eliminate the restriction to surfaces with negative Gaussian curvature. © 2013 Elsevier B.V.
Smoothed generalized free energies for thermodynamics
van der Meer, Remco; Ng, Nelly Huei Ying; Wehner, Stephanie
2017-12-01
In the study of thermodynamics for nanoscale quantum systems, a family of quantities known as generalized free energies have been derived as necessary and sufficient conditions that govern state transitions. These free energies become important especially in the regime where the system of interest consists of only a few (quantum) particles. In this work, we introduce a family of smoothed generalized free energies, by constructing explicit smoothing procedures that maximize or minimize the free energy over an ɛ ball of quantum states. In contrast to previously known smoothed free energies, these quantities now allow us to make an operational statement for approximate thermodynamic state transitions. We show that these smoothed quantities converge to the standard free energy in the thermodynamic limit.
Susceptibility to malignant hyperthermia
Snoeck, Marcus Matheus Johannes
2004-01-01
In this thesis the author studied the diagnostic procedures for susceptibility to malignant hyperthermia (MH), with special emphasis upon refining the biological diagnostic test and improving protocols and guidelines for investigation of MH susceptibility. MH is a pharmacogenetic disease of skeletal
Doing smooth pursuit paradigms in Windows 7
DEFF Research Database (Denmark)
Wilms, Inge Linda
Smooth pursuit eye movements are interesting to study as they reflect the subject’s ability to predict movement of external targets, keep focus and move the eyes appropriately. The process of smooth pursuit requires collaboration between several systems in the brain and the resulting action may p...... in Windows 7 with live capturing of eye movements using a Tobii TX300 eye tracker. In particular, the poster describes the challenges and limitations created by the hardware and the software...
Kalman Filter Desing, Smoothing and Analysis
Cederkvist, Henrik Rene
2001-01-01
Thesis is based on three different aspects of Kalman filtering. >Kalman filters for navigation. Investigate the difference between a Extended Kalman Filter and a Linearized Kalman Filter with feedback. And show how different system models relate to these Kalman Filters when implemented in a filter. >Smoothing. Investigate how much there is to be gained from smoothing. We will only look at the fixed-interval smoother, using the method of forward and backward filtering. ...
Smooth embeddings with Stein surface images
Gompf, Robert E.
2011-01-01
A simple characterization is given of open subsets of a complex surface that smoothly perturb to Stein open subsets. As applications, complex 2-space C^2 contains domains of holomorphy (Stein open subsets) that are exotic R^4's, and others homotopy equivalent to the 2-sphere but cut out by smooth, compact 3-manifolds. Pseudoconvex embeddings of Brieskorn spheres and other 3-manifolds into complex surfaces are constructed, as are pseudoconcave holomorphic fillings (with disagreeing contact and...
Some splines produced by smooth interpolation
Czech Academy of Sciences Publication Activity Database
Segeth, Karel
2018-01-01
Roč. 319, 15 February (2018), s. 387-394 ISSN 0096-3003 R&D Projects: GA ČR GA14-02067S Institutional support: RVO:67985840 Keywords : smooth data approximation * smooth data interpolation * cubic spline Subject RIV: BA - General Mathematics Impact factor: 1.738, year: 2016 http://www.sciencedirect.com/science/article/pii/S0096300317302746?via%3Dihub
Beam-smoothing investigation on Heaven I
Xiang, Yi-huai; Gao, Zhi-xing; Tong, Xiao-hui; Dai, Hui; Tang, Xiu-zhang; Shan, Yu-sheng
2007-01-01
Directly driven targets for inertial confinement fusion (ICF) require laser beams with extremely smooth irradiance profiles to prevent hydrodynamic instabilities that destroy the spherical symmetry of the target during implosion. Such instabilities can break up and mix together the target's wall and fuel material, preventing it from reaching the density and temperature required for fusion ignition. 1,2 Measurements in the equation of state (EOS) experiments require laser beams with flat-roofed profiles to generate uniform shockwave 3. Some method for beam smooth, is thus needed. A technique called echelon-free induced spatial incoherence (EFISI) is proposed for producing smooth target beam profiles with large KrF lasers. The idea is basically an image projection technique that projects the desired time-averaged spatial profile onto the target via the laser system, using partially coherent broadband lighe. Utilize the technique, we developing beam- smoothing investigation on "Heaven I". At China Institute of Atomic Energy , a new angular multiplexing providing with beam-smoothing function has been developed, the total energy is 158J, the stability of energy is 4%, the pulse duration is 25ns, the effective diameter of focusing spot is 400um, and the ununiformity is about 1.6%, the power density on the target is about 3.7×10 12W/cm2. At present, the system have provided steady and smooth laser irradiation for EOS experiments.
Nonequilibrium flows with smooth particle applied mechanics
Energy Technology Data Exchange (ETDEWEB)
Kum, Oyeon [Univ. of California, Davis, CA (United States)
1995-07-01
Smooth particle methods are relatively new methods for simulating solid and fluid flows through they have a 20-year history of solving complex hydrodynamic problems in astrophysics, such as colliding planets and stars, for which correct answers are unknown. The results presented in this thesis evaluate the adaptability or fitness of the method for typical hydrocode production problems. For finite hydrodynamic systems, boundary conditions are important. A reflective boundary condition with image particles is a good way to prevent a density anomaly at the boundary and to keep the fluxes continuous there. Boundary values of temperature and velocity can be separately controlled. The gradient algorithm, based on differentiating the smooth particle expression for (uρ) and (Tρ), does not show numerical instabilities for the stress tensor and heat flux vector quantities which require second derivatives in space when Fourier`s heat-flow law and Newton`s viscous force law are used. Smooth particle methods show an interesting parallel linking to them to molecular dynamics. For the inviscid Euler equation, with an isentropic ideal gas equation of state, the smooth particle algorithm generates trajectories isomorphic to those generated by molecular dynamics. The shear moduli were evaluated based on molecular dynamics calculations for the three weighting functions, B spline, Lucy, and Cusp functions. The accuracy and applicability of the methods were estimated by comparing a set of smooth particle Rayleigh-Benard problems, all in the laminar regime, to corresponding highly-accurate grid-based numerical solutions of continuum equations. Both transient and stationary smooth particle solutions reproduce the grid-based data with velocity errors on the order of 5%. The smooth particle method still provides robust solutions at high Rayleigh number where grid-based methods fails.
Manual tracking enhances smooth pursuit eye movements.
Niehorster, Diederick C; Siu, Wilfred W F; Li, Li
2015-01-01
Previous studies have reported that concurrent manual tracking enhances smooth pursuit eye movements only when tracking a self-driven or a predictable moving target. Here, we used a control-theoretic approach to examine whether concurrent manual tracking enhances smooth pursuit of an unpredictable moving target. In the eye-hand tracking condition, participants used their eyes to track a Gaussian target that moved randomly along a horizontal axis. In the meantime, they used their dominant hand to move a mouse to control the horizontal movement of a Gaussian cursor to vertically align it with the target. In the eye-alone tracking condition, the target and cursor positions recorded in the eye-hand tracking condition were replayed, and participants only performed eye tracking of the target. Catch-up saccades were identified and removed from the recorded eye movements, allowing for a frequency-response analysis of the smooth pursuit response to unpredictable target motion. We found that the overall smooth pursuit gain was higher and the number of catch-up saccades made was less when eye tracking was accompanied by manual tracking than when not. We conclude that concurrent manual tracking enhances smooth pursuit. This enhancement is a fundamental property of eye-hand coordination that occurs regardless of the predictability of the target motion.
Interstitial Cells: Regulators of Smooth Muscle Function
Sanders, Kenton M.; Ward, Sean M.; Koh, Sang Don
2014-01-01
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells. Interstitial cells of mesenchymal origin interact with and form electrical connectivity with smooth muscle cells in many organs, and these cells provide important regulatory functions. For example, in the gastrointestinal tract, interstitial cells of Cajal (ICC) and PDGFRα+ cells have been described, in detail, and represent distinct classes of cells with unique ultrastructure, molecular phenotypes, and functions. Smooth muscle cells are electrically coupled to ICC and PDGFRα+ cells, forming an integrated unit called the SIP syncytium. SIP cells express a variety of receptors and ion channels, and conductance changes in any type of SIP cell affect the excitability and responses of the syncytium. SIP cells are known to provide pacemaker activity, propagation pathways for slow waves, transduction of inputs from motor neurons, and mechanosensitivity. Loss of interstitial cells has been associated with motor disorders of the gut. Interstitial cells are also found in a variety of other smooth muscles; however, in most cases, the physiological and pathophysiological roles for these cells have not been clearly defined. This review describes structural, functional, and molecular features of interstitial cells and discusses their contributions in determining the behaviors of smooth muscle tissues. PMID:24987007
Smooth muscle actin and myosin expression in cultured airway smooth muscle cells.
Wong, J Z; Woodcock-Mitchell, J; Mitchell, J; Rippetoe, P; White, S; Absher, M; Baldor, L; Evans, J; McHugh, K M; Low, R B
1998-05-01
In this study, the expression of smooth muscle actin and myosin was examined in cultures of rat tracheal smooth muscle cells. Protein and mRNA analyses demonstrated that these cells express alpha- and gamma-smooth muscle actin and smooth muscle myosin and nonmuscle myosin-B heavy chains. The expression of the smooth muscle specific actin and myosin isoforms was regulated in the same direction when growth conditions were changed. Thus, at confluency in 1 or 10% serum-containing medium as well as for low-density cells (50-60% confluent) deprived of serum, the expression of the smooth muscle forms of actin and myosin was relatively high. Conversely, in rapidly proliferating cultures at low density in 10% serum, smooth muscle contractile protein expression was low. The expression of nonmuscle myosin-B mRNA and protein was more stable and was upregulated only to a small degree in growing cells. Our results provide new insight into the molecular basis of differentiation and contractile function in airway smooth muscle cells.
Cardiac, Skeletal, and smooth muscle mitochondrial respiration
DEFF Research Database (Denmark)
Park, Song-Young; Gifford, Jayson R; Andtbacka, Robert H I
2014-01-01
, skeletal, and smooth muscle was harvested from a total of 22 subjects (53±6 yrs) and mitochondrial respiration assessed in permeabilized fibers. Complex I+II, state 3 respiration, an index of oxidative phosphorylation capacity, fell progressively from cardiac, skeletal, to smooth muscle (54±1; 39±4; 15......±1 pmol•s(-1)•mg (-1), pindex of mitochondrial density, also fell progressively from cardiac, skeletal, to smooth muscle (222±13; 115±2; 48±2 umol•g(-1)•min(-1), p... per mitochondrial content), oxidative phosphorylation capacity was no longer different between the three muscle types. Interestingly, Complex I state 2 normalized for CS activity, an index of non-phosphorylating respiration per mitochondrial content, increased progressively from cardiac, skeletal...
Smoothing of Fused Spectral Consistent Satellite Images
DEFF Research Database (Denmark)
Sveinsson, Johannes; Aanæs, Henrik; Benediktsson, Jon Atli
2006-01-01
Several widely used methods have been proposed for fusing high resolution panchromatic data and lower resolution multi-channel data. However, many of these methods fail to maintain spectral consistency of the fused high resolution image, which is of high importance to many of the applications based...... in a statistically meaningful way. The fusion method was called spectral consistent panshapen- ing (SC) and it was shown that spectral consistency was a direct consequence of imaging physics and hence guaranteed by the SCP. In this paper exploit this framework and investigate two smoothing methods of the fused image...... obtain by SCP. The first smoothing method is based on Markov random field (MRF) model, while the second method uses wavelet domain hidden Markov models (HMM) for smoothing of the SCP fused image....
Multiple predictor smoothing methods for sensitivity analysis.
Energy Technology Data Exchange (ETDEWEB)
Helton, Jon Craig; Storlie, Curtis B.
2006-08-01
The use of multiple predictor smoothing methods in sampling-based sensitivity analyses of complex models is investigated. Specifically, sensitivity analysis procedures based on smoothing methods employing the stepwise application of the following nonparametric regression techniques are described: (1) locally weighted regression (LOESS), (2) additive models, (3) projection pursuit regression, and (4) recursive partitioning regression. The indicated procedures are illustrated with both simple test problems and results from a performance assessment for a radioactive waste disposal facility (i.e., the Waste Isolation Pilot Plant). As shown by the example illustrations, the use of smoothing procedures based on nonparametric regression techniques can yield more informative sensitivity analysis results than can be obtained with more traditional sensitivity analysis procedures based on linear regression, rank regression or quadratic regression when nonlinear relationships between model inputs and model predictions are present.
ibr: Iterative bias reduction multivariate smoothing
Energy Technology Data Exchange (ETDEWEB)
Hengartner, Nicholas W [Los Alamos National Laboratory; Cornillon, Pierre-andre [AGRO-SUP, FRANCE; Matzner - Lober, Eric [RENNES 2, FRANCE
2009-01-01
Regression is a fundamental data analysis tool for relating a univariate response variable Y to a multivariate predictor X {element_of} E R{sup d} from the observations (X{sub i}, Y{sub i}), i = 1,...,n. Traditional nonparametric regression use the assumption that the regression function varies smoothly in the independent variable x to locally estimate the conditional expectation m(x) = E[Y|X = x]. The resulting vector of predicted values {cflx Y}{sub i} at the observed covariates X{sub i} is called a regression smoother, or simply a smoother, because the predicted values {cflx Y}{sub i} are less variable than the original observations Y{sub i}. Linear smoothers are linear in the response variable Y and are operationally written as {cflx m} = X{sub {lambda}}Y, where S{sub {lambda}} is a n x n smoothing matrix. The smoothing matrix S{sub {lambda}} typically depends on a tuning parameter which we denote by {lambda}, and that governs the tradeoff between the smoothness of the estimate and the goodness-of-fit of the smoother to the data by controlling the effective size of the local neighborhood over which the responses are averaged. We parameterize the smoothing matrix such that large values of {lambda} are associated to smoothers that averages over larger neighborhood and produce very smooth curves, while small {lambda} are associated to smoothers that average over smaller neighborhood to produce a more wiggly curve that wants to interpolate the data. The parameter {lambda} is the bandwidth for kernel smoother, the span size for running-mean smoother, bin smoother, and the penalty factor {lambda} for spline smoother.
Local smoothness for global optical flow
DEFF Research Database (Denmark)
Rakêt, Lars Lau
2012-01-01
by this technique and work on local-global optical flow we propose a simple method for fusing optical flow estimates of different smoothness by evaluating interpolation quality locally by means of L1 block match on the corresponding set of gradient images. We illustrate the method in a setting where optical flows...... are estimated by a TV-L1 energy. On average this procedure reduces the average endpoint error by 15% over flows estimated using the OPP, and gives flow fields that are consistently better than the single best flows with a fixed smoothness parameter....
Production of super-smooth articles
Energy Technology Data Exchange (ETDEWEB)
Duchane, D.V.
1981-05-29
Super-smooth rounded or formed articles made of thermoplastic materials including various poly(methyl methacrylate) or acrylonitrile-butadiene-styrene copolymers are produced by immersing the articles into a bath, the composition of which is slowly changed with time. The starting composition of the bath is made up of at least one solvent for the polymer and a diluent made up of at least one nonsolvent for the polymer and optional materials which are soluble in the bath. The resulting extremely smooth articles are useful as mandrels for laser fusion and should be useful for a wide variety of other purposes, for example lenses.
Analysis of Two Advanced Smoothing Algorithms.
1985-09-01
equations 1.3 19 - and 1.4. The problem with this method is that the smoothing program may have to be run several times with each run containing a...uruie 48iOsragtln thog pont in wido Fi I ..ea .n to enpont an eta on :7-" - - . . . .I SUNIXY NC.1.XSZ O (3.10) For each I=1, ., (MNWNSZ-1), the right...smoothed point values were plotted, the plot would show too many peaks and would appear very jagged. In order to alleviate this problem , these
Autophagic regulation of smooth muscle cell biology
Directory of Open Access Journals (Sweden)
Joshua K. Salabei
2015-04-01
Full Text Available Autophagy regulates the metabolism, survival, and function of numerous cell types, including those comprising the cardiovascular system. In the vasculature, changes in autophagy have been documented in atherosclerotic and restenotic lesions and in hypertensive vessels. The biology of vascular smooth muscle cells appears particularly sensitive to changes in the autophagic program. Recent evidence indicates that stimuli or stressors evoked during the course of vascular disease can regulate autophagic activity, resulting in modulation of VSMC phenotype and viability. In particular, certain growth factors and cytokines, oxygen tension, and pharmacological drugs have been shown to trigger autophagy in smooth muscle cells. Importantly, each of these stimuli has a redox component, typically associated with changes in the abundance of reactive oxygen, nitrogen, or lipid species. Collective findings support the hypothesis that autophagy plays a critical role in vascular remodeling by regulating smooth muscle cell phenotype transitions and by influencing the cellular response to stress. In this graphical review, we summarize current knowledge on the role of autophagy in the biology of the smooth muscle cell in (pathophysiology.
Interval Forecast for Smooth Transition Autoregressive Model ...
African Journals Online (AJOL)
In this paper, we propose a simple method for constructing interval forecast for smooth transition autoregressive (STAR) model. This interval forecast is based on bootstrapping the residual error of the estimated STAR model for each forecast horizon and computing various Akaike information criterion (AIC) function. This new ...
Full Waveform Inversion Using Nonlinearly Smoothed Wavefields
Li, Y.
2017-05-26
The lack of low frequency information in the acquired data makes full waveform inversion (FWI) conditionally converge to the accurate solution. An initial velocity model that results in data with events within a half cycle of their location in the observed data was required to converge. The multiplication of wavefields with slightly different frequencies generates artificial low frequency components. This can be effectively utilized by multiplying the wavefield with itself, which is nonlinear operation, followed by a smoothing operator to extract the artificially produced low frequency information. We construct the objective function using the nonlinearly smoothed wavefields with a global-correlation norm to properly handle the energy imbalance in the nonlinearly smoothed wavefield. Similar to the multi-scale strategy, we progressively reduce the smoothing width applied to the multiplied wavefield to welcome higher resolution. We calculate the gradient of the objective function using the adjoint-state technique, which is similar to the conventional FWI except for the adjoint source. Examples on the Marmousi 2 model demonstrate the feasibility of the proposed FWI method to mitigate the cycle-skipping problem in the case of a lack of low frequency information.
Smooth rank one perturbations of selfadjoint operators
Hassi, Seppo; Snoo, H.S.V. de; Willemsma, A.D.I.
Let A be a selfadjoint operator in a Hilbert space aleph with inner product [.,.]. The rank one perturbations of A have the form A+tau [.,omega]omega, tau epsilon R, for some element omega epsilon aleph. In this paper we consider smooth perturbations, i.e. we consider omega epsilon dom \\A\\(k/2) for
Role of Smooth Muscle in Intestinal Inflammation
Directory of Open Access Journals (Sweden)
Stephen M Collins
1996-01-01
Full Text Available The notion that smooth muscle function is altered in inflammation is prompted by clinical observations of altered motility in patients with inflammatory bowel disease (IBD. While altered motility may reflect inflammation-induced changes in intrinsic or extrinsic nerves to the gut, changes in gut hormone release and changes in muscle function, recent studies have provided in vitro evidence of altered muscle contractility in muscle resected from patients with ulcerative colitis or Crohn’s disease. In addition, the observation that smooth muscle cells are more numerous and prominent in the strictured bowel of IBD patients compared with controls suggests that inflammation may alter the growth of intestinal smooth muscle. Thus, inflammation is associated with changes in smooth muscle growth and contractility that, in turn, contribute to important symptoms of IBD including diarrhea (from altered motility and pain (via either altered motility or stricture formation. The involvement of smooth muscle in this context may be as an innocent bystander, where cells and products of the inflammatory process induce alterations in muscle contractility and growth. However, it is likely that intestinal muscle cells play a more active role in the inflammatory process via the elaboration of mediators and trophic factors, including cytokines, and via the production of collagen. The concept of muscle cells as active participants in the intestinal inflammatory process is a new concept that is under intense study. This report summarizes current knowledge as it relates to these two aspects of altered muscle function (growth and contractility in the inflamed intestine, and will focus on mechanisms underlying these changes, based on data obtained from animal models of intestinal inflammation.
Genetic susceptibility of periodontitis
Laine, M.L.; Crielaard, W.; Loos, B.G.
2012-01-01
In this systematic review, we explore and summarize the peer-reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal
African Journals Online (AJOL)
Prof. Adipala Ekwamu
a number of cultivars exhibited field resistance to halo blight and bacterial brown spot, all cultivars were more or less susceptible to .... Cerillos. Alubia. I. 91. 57. Kranskop. Red speckled sugar. II. 97. 63. OPS-RS1. Red speckled sugar. II. 96. 63. OPS-RS2. Red speckled sugar. I. 100. 61. OPS-RS3. Red speckled sugar. II. 97.
Semiparametric smoothing of discrete failure time data.
Patil, Prakash N; Bagkavos, Dimitrios
2012-01-01
An estimator of the hazard rate function from discrete failure time data is obtained by semiparametric smoothing of the (nonsmooth) maximum likelihood estimator, which is achieved by repeated multiplication of a Markov chain transition-type matrix. This matrix is constructed so as to have a given standard discrete parametric hazard rate model, termed the vehicle model, as its stationary hazard rate. As with the discrete density estimation case, the proposed estimator gives improved performance when the vehicle model is a good one and otherwise provides a nonparametric method comparable to the only purely nonparametric smoother discussed in the literature. The proposed semiparametric smoothing approach is then extended to hazard models with covariates and is illustrated by applications to simulated and real data sets. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Tame geometry with application in smooth analysis
Yomdin, Yosef
2004-01-01
The Morse-Sard theorem is a rather subtle result and the interplay between the high-order analytic structure of the mappings involved and their geometry rarely becomes apparent. The main reason is that the classical Morse-Sard theorem is basically qualitative. This volume gives a proof and also an "explanation" of the quantitative Morse-Sard theorem and related results, beginning with the study of polynomial (or tame) mappings. The quantitative questions, answered by a combination of the methods of real semialgebraic and tame geometry and integral geometry, turn out to be nontrivial and highly productive. The important advantage of this approach is that it allows the separation of the role of high differentiability and that of algebraic geometry in a smooth setting: all the geometrically relevant phenomena appear already for polynomial mappings. The geometric properties obtained are "stable with respect to approximation", and can be imposed on smooth functions via polynomial approximation.
Cortex phellodendri Extract Relaxes Airway Smooth Muscle
Qiu-Ju Jiang; Weiwei Chen; Hong Dan; Li Tan; He Zhu; Guangzhong Yang; Jinhua Shen; Yong-Bo Peng; Ping Zhao; Lu Xue; Meng-Fei Yu; Liqun Ma; Xiao-Tang Si; Zhuo Wang; Jiapei Dai
2016-01-01
Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alcohol extract of C. phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smoo...
On the thermodynamics of smooth muscle contraction
Stålhand, Jonas; McMeeking, Robert M.; Holzapfel, Gerhard A.
2016-09-01
Cell function is based on many dynamically complex networks of interacting biochemical reactions. Enzymes may increase the rate of only those reactions that are thermodynamically consistent. In this paper we specifically treat the contraction of smooth muscle cells from the continuum thermodynamics point of view by considering them as an open system where matter passes through the cell membrane. We systematically set up a well-known four-state kinetic model for the cross-bridge interaction of actin and myosin in smooth muscle, where the transition between each state is driven by forward and reverse reactions. Chemical, mechanical and energy balance laws are provided in local forms, while energy balance is also formulated in the more convenient temperature form. We derive the local (non-negative) production of entropy from which we deduce the reduced entropy inequality and the constitutive equations for the first Piola-Kirchhoff stress tensor, the heat flux, the ion and molecular flux and the entropy. One example for smooth muscle contraction is analyzed in more detail in order to provide orientation within the established general thermodynamic framework. In particular the stress evolution, heat generation, muscle shorting rate and a condition for muscle cooling are derived.
How Do Families Smooth Household Heads` Earnings Volatility?
National Research Council Canada - National Science Library
Ki Seong Park;
2010-01-01
...` earnings is almost entirely smoothed. The most effective measure of smoothing heads` earnings volatility is income from self-employment, with the next most effective being labor income of other family members...
Genetic Susceptibility to Atherosclerosis
Directory of Open Access Journals (Sweden)
Sanja Kovacic
2012-01-01
Full Text Available Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.
Smoothed nonparametric estimation for current status competing risks data
Chenxi Li; Jason P. Fine
2013-01-01
We study the nonparametric estimation of the cumulative incidence function and the cause-specific hazard function for current status data with competing risks via kernel smoothing. A smoothed naive nonparametric maximum likelihood estimator and a smoothed full nonparametric maximum likelihood estimator are shown to have pointwise asymptotic normality and faster convergence rates than the corresponding unsmoothed nonparametric likelihood estimators. Using the smoothed estimators and the plug-i...
Marijuana Usage and Hypnotic Susceptibility
Franzini, Louis R.; McDonald, Roy D.
1973-01-01
Anonymous self-reported drug usage data and hypnotic susceptibility scores were obtained from 282 college students. Frequent marijuana users (more than 10 times) showed greater susceptibility to hypnosis than nonusers. (Author)
Smooth Fano polytopes can not be inductively constructed
DEFF Research Database (Denmark)
Øbro, Mikkel
2008-01-01
We examine a concrete smooth Fano 5-polytope $P$ with 8 vertices with the following properties: There does not exist a smooth Fano 5-polytope $Q$ with 7 vertices such that $P$ contains $Q$, and there does not exist a smooth Fano 5-polytope $R$ with 9 vertices such that $R$ contains $P$. As the po...
Evaluating the use of spiny pigweed (Amaranthus Spinosus) and ...
African Journals Online (AJOL)
ADOWIE PERE
The branches have two lateral basal buds. The leaves are spirally arranged to nearly opposite, often crowded at the top of the stem. .... The sample was automatically detected as it emerges from the column (at a constant flow rate) by the FID detector whose response is dependent upon the composition of the vapour.
Influence of tectonic folding on rockfall susceptibility, American Fork Canyon, Utah, USA
Directory of Open Access Journals (Sweden)
J. A. Coe
2007-01-01
Full Text Available We examine rockfall susceptibility of folded strata in the Sevier fold-thrust belt exposed in American Fork Canyon in north-central Utah. Large-scale geologic mapping, talus production data, rock-mass-quality measurements, and historical rockfall data indicate that rockfall susceptibility is correlated with limb dip and curvature of the folded, cliff-forming Mississippian limestones. On fold limbs, rockfall susceptibility increases as dip increases. This relation is controlled by several factors, including an increase in adverse dip conditions and apertures of discontinuities, and shearing by flexural slip during folding that has reduced the friction angles of discontinuities by smoothing surface asperities. Susceptibility is greater in fold hinge zones than on adjacent limbs primarily because there are greater numbers of discontinuities in hinge zones. We speculate that susceptibility increases in hinge zones as fold curvature becomes tighter.
Smoothed Analysis for the Conjugate Gradient Algorithm
Menon, Govind; Trogdon, Thomas
2016-11-01
The purpose of this paper is to establish bounds on the rate of convergence of the conjugate gradient algorithm when the underlying matrix is a random positive definite perturbation of a deterministic positive definite matrix. We estimate all finite moments of a natural halting time when the random perturbation is drawn from the Laguerre unitary ensemble in a critical scaling regime explored in Deift et al. (2016). These estimates are used to analyze the expected iteration count in the framework of smoothed analysis, introduced by Spielman and Teng (2001). The rigorous results are compared with numerical calculations in several cases of interest.
Smooth leading edge transition in hypersonic flow
Energy Technology Data Exchange (ETDEWEB)
Gaillard, L.; Benard, E.; Alziary de Roquefort, T. [CEAT, Poitiers (France). Lab. d`Etudes Aerodynamiques
1999-01-01
The boundary layer transition along the attachment line of a smooth swept circular cylinder in hypersonic flow is investigated in a blowdown wind tunnel. A wide range of spanwise Mach numbers Me (3.28 to 6.78) is covered with the help of different models at several sweep angles (60 {<=}{Lambda}{<=}80 ). The transition is indirectly detected by means of heat flux measurements. The influence of the wall to stagnation temperature ratio is investigated by cooling the model with liquid nitrogen. (orig.) With 9 figs., 2 tabs., 30 refs.
Vestibular activation, smooth pursuit tracking, and psychosis.
Jones, A M; Pivik, R T
1985-04-01
Pursuit tracking and vestibular activation procedures were combined in an investigation to determine if smooth pursuit tracking deficits could be related to abnormalities of visual-vestibular interaction in psychiatric patients. In actively psychotic patients, but not in comparison groups of schizophrenic outpatients with remitted symptomatology or normal controls, a significant failure of visual fixation to suppress caloric nystagmus was related to a higher incidence of disordered tracking during both baseline and postirrigation conditions. Other vestibular irregularities including dysrhythmia and reduced fast phase velocity were observed in these same patients. The results are supportive of a central deficit in visual-vestibular interaction that may contribute to pursuit tracking deficits in psychosis.
Smooth Nanowire/Polymer Composite Transparent Electrodes
Gaynor, Whitney
2011-04-29
Smooth composite transparent electrodes are fabricated via lamination of silver nanowires into the polymer poly-(4,3-ethylene dioxythiophene): poly(styrene-sulfonate) (PEDOT:PSS). The surface roughness is dramatically reduced compared to bare nanowires. High-efficiency P3HT:PCBM organic photovoltaic cells can be fabricated using these composites, reproducing the performance of cells on indium tin oxide (ITO) on glass and improving the performance of cells on ITO on plastic. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Smooth nanowire/polymer composite transparent electrodes
Energy Technology Data Exchange (ETDEWEB)
Gaynor, Whitney; McGehee, Michael D. [Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305 (United States); Burkhard, George F. [Department of Applied Physics, Stanford University, Stanford, CA 94305 (United States); Peumans, Peter [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States)
2011-07-12
Smooth composite transparent electrodes are fabricated via lamination of silver nanowires into the polymer poly-(4,3-ethylene dioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS). The surface roughness is dramatically reduced compared to bare nanowires. High-efficiency P3HT:PCBM organic photovoltaic cells can be fabricated using these composites, reproducing the performance of cells on indium tin oxide (ITO) on glass and improving the performance of cells on ITO on plastic. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)
Peinke, J.; Parisi, J.; Röhricht, B.; Rössler, O. E.; Metzler, W.
1988-01-01
Generalized Mandelbrot sets arise in perturbed (non-analytic) versions of the complex logistic map. Numerically, it contains smooth portions as shown previously. To exclude that this result is specific to particular initial conditions only, the structure of the analogue to the Fatou set is looked at in the region in question. The set of non-divergent points is being "eaten up" by a smooth invading boundary. Therefore, the same type of decomposition applies independent of position in parameter space, in the region in question.
Coupling of smooth particle hydrodynamics with PRONTO
Energy Technology Data Exchange (ETDEWEB)
Attaway, S.W.; Heinstein, M.W.; Mello, F.J.; Swegle, J.W.
1993-08-01
A gridless numerical technique called smooth particle hydrodynamics (SPH) has been coupled to the transient dynamics finite element code, PRONTO. In this paper, a new weighted residual derivation for the SPH method will be presented, and the methods used to embed SPH within PRONTO will be outlined. Example SPH-PRONTO calculations will also be presented. One major difficulty associated with the Lagrangian finite element method is modeling materials with no shear strength; for example, gases, fluids and explosive bi-products. Typically these materials can be modeled for only a short time with a Lagrangian finite element code. Large distortions cause tangling of the mesh, which will eventually lead to numerical difficulties such as negative element area or ``bow tie`` elements. Remeshing will allow the problem to continue for a short while, but the large distortions can prevent a complete analysis. Smooth particle hydrodynamics is a gridless Lagrangian technique. Requiring no mesh, SPH has the potential to model material fracture, large shear flows, and penetration. SPH computes the strain rate and the stress divergence based on the nearest neighbors of a particle, which are determined using an efficient particle sorting technique. Embedding the SPH method within PRONTO allows part of the problem to be modeled with quadrilateral finite elements while other parts are modeled with the gridless SPH method. SPH elements are coupled to the quadrilateral elements through a contact like algorithm.
Cortex phellodendri Extract Relaxes Airway Smooth Muscle
Directory of Open Access Journals (Sweden)
Qiu-Ju Jiang
2016-01-01
Full Text Available Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM; however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alcohol extract of C. phellodendri (NBAECP, nonberberine component was prepared, which completely inhibits high K+- and acetylcholine- (ACH- induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively. The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels. The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels. Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm.
Cortex phellodendri Extract Relaxes Airway Smooth Muscle
Jiang, Qiu-Ju; Chen, Weiwei; Dan, Hong; Tan, Li; Zhu, He; Yang, Guangzhong; Shen, Jinhua; Peng, Yong-Bo; Zhao, Ping; Xue, Lu; Yu, Meng-Fei; Ma, Liqun; Si, Xiao-Tang; Wang, Zhuo; Dai, Jiapei; Qin, Gangjian; Zou, Chunbin; Liu, Qing-Hua
2016-01-01
Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alcohol extract of C. phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively. The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels. The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels. Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm. PMID:27239213
REACTIVE POWER COMPENSATOR WITH SMOOTH CONTROL
Directory of Open Access Journals (Sweden)
V. V. Burlaka
2014-12-01
Full Text Available Reactive power compensation devices are widely used: thyristor-control reactors (TCR and thyristor-switched capacitors (TSC. The TCR disadvantages are discussed. The TSC disadvantages are: influence of higher harmonics on nonsinusoidal voltage power system, the inability to ensure the smooth regulation. The proposed reactive power compensator consists of series with active filter and capacitors with step switch. Reactive power compensator’s control system is proposed. Hysteretic control of the inverter with current feedback is applied. DC-voltage regulator provides balance of active power. The control system allows overcompensation or undercompensation of reactive power modes. Reactive power distribution regulator performs the redistribution of power between switching capacitors and active filter. Minimization condition of this regulator is active filter’s power. Adjustment properties of reactive power compensator are analyzed. The choice of relations between the capacitors TSC steps to minimize the installed capacity of the active filter and the number of stages in TSC is considered. The approach that makes possible to «isolate» capacitors from harmonic currents and provide smooth control of reactive power is proposed
Smooth manifold structure for extreme channels
Iten, Raban; Colbeck, Roger
2018-01-01
A quantum channel from a system A of dimension dA to a system B of dimension dB is a completely positive trace-preserving map from complex dA × dA to dB × dB matrices, and the set of all such maps with Kraus rank r has the structure of a smooth manifold. We describe this set in two ways. First, as a quotient space of (a subset of) the rdB × dA dimensional Stiefel manifold. Second, as the set of all Choi-states of a fixed rank r. These two descriptions are topologically equivalent. This allows us to show that the set of all Choi-states corresponding to extreme channels from system A to system B of a fixed Kraus rank r is a smooth submanifold of dimension 2 r dAdB-dA2-r2 of the set of all Choi-states of rank r. As an application, we derive a lower bound on the number of parameters required for a quantum circuit topology to be able to approximate all extreme channels from A to B arbitrarily well.
Magnetic susceptibilities of minerals
Rosenblum, Sam; Brownfield, I.K.
2000-01-01
Magnetic separation of minerals is a topic that is seldom reported in the literature for two reasons. First, separation data generally are byproducts of other projects; and second, this study requires a large amount of patience and is unusually tedious. Indeed, we suspect that most minerals probably are never investigated for this property. These data are timesaving for mineralogists who concentrate mono-mineralic fractions for chemical analysis, age dating, and for other purposes. The data can certainly be used in the ore-beneficiation industries. In some instances, magnetic-susceptibility data may help in mineral identification, where other information is insufficient. In past studies of magnetic separation of minerals, (Gaudin and Spedden, 1943; Tille and Kirkpatrick, 1956; Rosenblum, 1958; Rubinstein and others, 1958; Flinter, 1959; Hess, 1959; Baker, 1962; Meric and Peyre, 1963; Rojas and others, 1965; and Duchesne, 1966), the emphasis has been on the ferromagnetic and paramagnetic ranges of extraction. For readers interested in the history of magnetic separation of minerals, Krumbein and Pettijohn (1938, p. 344-346) indicated nine references back to 1848. The primary purpose of this paper is to report the magnetic-susceptibility data on as many minerals as possible, similar to tables of hardness, specific gravity, refractive indices, and other basic physical properties of minerals. A secondary purpose is to demonstrate that the total and best extraction ranges are influenced by the chemistry of the minerals. The following notes are offered to help avoid problems in separating a desired mineral concentrate from mixtures of mineral grains.
Alcohol increases hypnotic susceptibility.
Semmens-Wheeler, Rebecca; Dienes, Zoltán; Duka, Theodora
2013-09-01
One approach to hypnosis suggests that for hypnotic experience to occur frontal lobe activity must be attenuated. For example, cold control theory posits that a lack of awareness of intentions is responsible for the experience of involuntariness and/or the subjective reality of hypnotic suggestions. The mid-dorso-lateral prefrontal cortex and the ACC are candidate regions for such awareness. Alcohol impairs frontal lobe executive function. This study examined whether alcohol affects hypnotisability. We administered 0.8 mg/kg of alcohol or a placebo to 32 medium susceptible participants. They were subsequently hypnotised and given hypnotic suggestions. All participants believed they had received some alcohol. Participants in the alcohol condition were more susceptible to hypnotic suggestions than participants in the placebo condition. Impaired frontal lobe activity facilitates hypnotic responding, which supports theories postulating that attenuation of executive function facilitates hypnotic response, and contradicts theories postulating that hypnotic response involves enhanced inhibitory, attentional or other executive function. Copyright © 2013. Published by Elsevier Inc.
Raizada, Rajeev D S; Lee, Yune-Sang
2013-01-01
Spatial smoothness is helpful when averaging fMRI signals across multiple subjects, as it allows different subjects' corresponding brain areas to be pooled together even if they are slightly misaligned. However, smoothing is usually not applied when performing multivoxel pattern-based analyses (MVPA), as it runs the risk of blurring away the information that fine-grained spatial patterns contain. It would therefore be desirable, if possible, to carry out pattern-based analyses which take unsmoothed data as their input but which produce smooth images as output. We show here that the Gaussian Naive Bayes (GNB) classifier does precisely this, when it is used in "searchlight" pattern-based analyses. We explain why this occurs, and illustrate the effect in real fMRI data. Moreover, we show that analyses using GNBs produce results at the multi-subject level which are statistically robust, neurally plausible, and which replicate across two independent data sets. By contrast, SVM classifiers applied to the same data do not generate a replication, even if the SVM-derived searchlight maps have smoothing applied to them. An additional advantage of GNB classifiers for searchlight analyses is that they are orders of magnitude faster to compute than more complex alternatives such as SVMs. Collectively, these results suggest that Gaussian Naive Bayes classifiers may be a highly non-naive choice for multi-subject pattern-based fMRI studies.
Directory of Open Access Journals (Sweden)
Rajeev D S Raizada
Full Text Available Spatial smoothness is helpful when averaging fMRI signals across multiple subjects, as it allows different subjects' corresponding brain areas to be pooled together even if they are slightly misaligned. However, smoothing is usually not applied when performing multivoxel pattern-based analyses (MVPA, as it runs the risk of blurring away the information that fine-grained spatial patterns contain. It would therefore be desirable, if possible, to carry out pattern-based analyses which take unsmoothed data as their input but which produce smooth images as output. We show here that the Gaussian Naive Bayes (GNB classifier does precisely this, when it is used in "searchlight" pattern-based analyses. We explain why this occurs, and illustrate the effect in real fMRI data. Moreover, we show that analyses using GNBs produce results at the multi-subject level which are statistically robust, neurally plausible, and which replicate across two independent data sets. By contrast, SVM classifiers applied to the same data do not generate a replication, even if the SVM-derived searchlight maps have smoothing applied to them. An additional advantage of GNB classifiers for searchlight analyses is that they are orders of magnitude faster to compute than more complex alternatives such as SVMs. Collectively, these results suggest that Gaussian Naive Bayes classifiers may be a highly non-naive choice for multi-subject pattern-based fMRI studies.
Raizada, Rajeev D. S.; Lee, Yune-Sang
2013-01-01
Spatial smoothness is helpful when averaging fMRI signals across multiple subjects, as it allows different subjects' corresponding brain areas to be pooled together even if they are slightly misaligned. However, smoothing is usually not applied when performing multivoxel pattern-based analyses (MVPA), as it runs the risk of blurring away the information that fine-grained spatial patterns contain. It would therefore be desirable, if possible, to carry out pattern-based analyses which take unsmoothed data as their input but which produce smooth images as output. We show here that the Gaussian Naive Bayes (GNB) classifier does precisely this, when it is used in “searchlight” pattern-based analyses. We explain why this occurs, and illustrate the effect in real fMRI data. Moreover, we show that analyses using GNBs produce results at the multi-subject level which are statistically robust, neurally plausible, and which replicate across two independent data sets. By contrast, SVM classifiers applied to the same data do not generate a replication, even if the SVM-derived searchlight maps have smoothing applied to them. An additional advantage of GNB classifiers for searchlight analyses is that they are orders of magnitude faster to compute than more complex alternatives such as SVMs. Collectively, these results suggest that Gaussian Naive Bayes classifiers may be a highly non-naive choice for multi-subject pattern-based fMRI studies. PMID:23922740
Liu, Xiaofeng; Bo, Lin; Luo, Honglin
2016-04-01
In this paper, smoothing localized directional cyclic autocorrelation (SLDCA) is proposed as a novel time-frequency distribution to analyze the vibration signal of rotor-bearing system in oil-film instability. Based on the cyclostationarity of real-valued signal, directional cyclic autocorrelation (DCA) is defined for the complex-valued signal. In order to suppress the cross-term interferences, the DCA is localized and filtered with two-dimensional time-frequency window which allows the smoothing kernel function to adapt to the signal time-frequency-varying characteristics. And then the localized DCA is smoothed by the localized optimal radially Gaussian kernel and cascaded to produce the SLDCA with high time-frequency resolution and less susceptibility to cross-term interferences. The application of SLDCA in the oil-film instability analysis verifies that the SLDCA can not only precisely detect the instantaneous frequency information in the time-frequency distribution with high resolution and robustness to the noises and cross-terms, but also provide the phase coupling information of rotor instantaneous planar motion by which the directivity and shape of the planar motion can be determined.
An earthquake rate forecast for Europe based on smoothed seismicity and smoothed fault contribution
Hiemer, Stefan; Woessner, Jochen; Basili, Roberto; Wiemer, Stefan
2013-04-01
The main objective of project SHARE (Seismic Hazard Harmonization in Europe) is to develop a community-based seismic hazard model for the Euro-Mediterranean region. The logic tree of earthquake rupture forecasts comprises several methodologies including smoothed seismicity approaches. Smoothed seismicity thus represents an alternative concept to express the degree of spatial stationarity of seismicity and provides results that are more objective, reproducible, and testable. Nonetheless, the smoothed-seismicity approach suffers from the common drawback of being generally based on earthquake catalogs alone, i.e. the wealth of knowledge from geology is completely ignored. We present a model that applies the kernel-smoothing method to both past earthquake locations and slip rates on mapped crustal faults and subductions. The result is mainly driven by the data, being independent of subjective delineation of seismic source zones. The core parts of our model are two distinct location probability densities: The first is computed by smoothing past seismicity (using variable kernel smoothing to account for varying data density). The second is obtained by smoothing fault moment rate contributions. The fault moment rates are calculated by summing the moment rate of each fault patch on a fully parameterized and discretized fault as available from the SHARE fault database. We assume that the regional frequency-magnitude distribution of the entire study area is well known and estimate the a- and b-value of a truncated Gutenberg-Richter magnitude distribution based on a maximum likelihood approach that considers the spatial and temporal completeness history of the seismic catalog. The two location probability densities are linearly weighted as a function of magnitude assuming that (1) the occurrence of past seismicity is a good proxy to forecast occurrence of future seismicity and (2) future large-magnitude events occur more likely in the vicinity of known faults. Consequently
Graphene susceptibility in Holstein model
Energy Technology Data Exchange (ETDEWEB)
Mousavi, Hamze, E-mail: hamze.mousavi@gmail.co [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of); Nano Science and Nano Technology Research Center, Razi University, Kermanshah (Iran, Islamic Republic of)
2011-06-15
We study the effects of the electron-phonon interaction on the temperature dependence of the orbital magnetic susceptibility of monolayer graphene. We use the linear response theory and Green's function formalism within the Holstein Hamiltonian model. The results show that the effects of the electron-phonon interaction on the susceptibility of graphene sheet have different behaviors in two temperature regions. In the low temperature region, susceptibility increases when the electron-phonon coupling strength increases. On the other hand, the susceptibility reduces with increasing the electron-phonon coupling strength in the high temperature region. - Highlights: Effect of electron-phonon interaction on the susceptibility of graphene is studied. Linear response theory and Green's function technique in Holstein model are used. Effect of electron-phonon on susceptibility has different behaviors in two temperature regions.
Topological susceptibility from slabs
Energy Technology Data Exchange (ETDEWEB)
Bietenholz, Wolfgang [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Forcrand, Philippe de [Institute for Theoretical Physics, ETH Zürich,CH-8093 Zürich (Switzerland); CERN, Physics Department, TH Unit, CH-1211 Geneva 23 (Switzerland); Gerber, Urs [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo,Edificio C-3, Apdo. Postal 2-82, Morelia, Michoacán, C.P. 58040 (Mexico)
2015-12-14
In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility χ{sub t}. In principle it seems straightforward to measure χ{sub t} by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure χ{sub t} even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of χ{sub t}, as we demonstrate with numerical results for non-linear σ-models.
Topological Susceptibility from Slabs
Bietenholz, Wolfgang; Gerber, Urs
2015-01-01
In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure chi_t even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of chi_t, as we demonstrate with numerical results for non-linear sigma-models.
An analysis of smoothed particle hydrodynamics
Energy Technology Data Exchange (ETDEWEB)
Swegle, J.W.; Attaway, S.W.; Heinstein, M.W.; Mello, F.J. [Sandia National Labs., Albuquerque, NM (United States); Hicks, D.L. [Michigan Technological Univ., Houghton, MI (United States)
1994-03-01
SPH (Smoothed Particle Hydrodynamics) is a gridless Lagrangian technique which is appealing as a possible alternative to numerical techniques currently used to analyze high deformation impulsive loading events. In the present study, the SPH algorithm has been subjected to detailed testing and analysis to determine its applicability in the field of solid dynamics. An important result of the work is a rigorous von Neumann stability analysis which provides a simple criterion for the stability or instability of the method in terms of the stress state and the second derivative of the kernel function. Instability, which typically occurs only for solids in tension, results not from the numerical time integration algorithm, but because the SPH algorithm creates an effective stress with a negative modulus. The analysis provides insight into possible methods for removing the instability. Also, SPH has been coupled into the transient dynamics finite element code PRONTO, and a weighted residual derivation of the SPH equations has been obtained.
Clip art rendering of smooth isosurfaces.
Stroila, Matei; Eisemann, Elmar; Hart, John
2008-01-01
Clip art is a simplified illustration form consisting of layered filled polygons or closed curves used to convey 3D shape information in a 2D vector graphics format. This paper focuses on the problem of direct conversion of smooth surfaces, ranging from the free-form shapes of art and design to the mathematical structures of geometry and topology, into a clip art form suitable for illustration use in books, papers and presentations. We show how to represent silhouette, shadow, gleam and other surface feature curves as the intersection of implicit surfaces, and derive equations for their efficient interrogation via particle chains. We further describe how to sort, orient, identify and fill the closed regions that overlay to form clip art. We demonstrate the results with numerous renderings used to illustrate the paper itself.
On the dynamic smoothing of mountains
Bonetti, S.; Porporato, A.
2017-06-01
After their formation, mountainous landscapes gradually evolve toward smoother geometries controlled by the interplay of erosion and sedimentation. The statistical mechanical properties of this process and the link between topography and geology have remained largely unexplored. We analyze the slope statistics of different mountains worldwide, showing that landscape age is fingerprinted in their distribution tails. Data reveal a universal relaxation process, through an algebraic decay progressively replaced by an exponential one, with exponents described by a global monotonic function. We then investigate the dominant components of this dynamic smoothing using a landscape evolution model, showing that the time evolution of slope statistics results from a delicate balance between diffusive soil creep, noise, and advective river incision, with the relaxation phase mainly dominated by diffusion. Results may suggest ways to formulate reduced order topographic evolution models for geomorphological and climatological applications, and to explore similarities in surface evolution in different contexts.
Video tonal stabilization via color states smoothing.
Wang, Yinting; Tao, Dacheng; Li, Xiang; Song, Mingli; Bu, Jiajun; Tan, Ping
2014-11-01
We address the problem of removing video color tone jitter that is common in amateur videos recorded with hand-held devices. To achieve this, we introduce color state to represent the exposure and white balance state of a frame. The color state of each frame can be computed by accumulating the color transformations of neighboring frame pairs. Then, the tonal changes of the video can be represented by a time-varying trajectory in color state space. To remove the tone jitter, we smooth the original color state trajectory by solving an L1 optimization problem with PCA dimensionality reduction. In addition, we propose a novel selective strategy to remove small tone jitter while retaining extreme exposure and white balance changes to avoid serious artifacts. Quantitative evaluation and visual comparison with previous work demonstrate the effectiveness of our tonal stabilization method. This system can also be used as a preprocessing tool for other video editing methods.
Adaptively Smoothed Seismicity Earthquake Forecasts for Italy
Werner, M J; Jackson, D D; Kagan, Y Y; Wiemer, S
2010-01-01
We present a model for estimating the probabilities of future earthquakes of magnitudes m > 4.95 in Italy. The model, a slightly modified version of the one proposed for California by Helmstetter et al. (2007) and Werner et al. (2010), approximates seismicity by a spatially heterogeneous, temporally homogeneous Poisson point process. The temporal, spatial and magnitude dimensions are entirely decoupled. Magnitudes are independently and identically distributed according to a tapered Gutenberg-Richter magnitude distribution. We estimated the spatial distribution of future seismicity by smoothing the locations of past earthquakes listed in two Italian catalogs: a short instrumental catalog and a longer instrumental and historical catalog. The bandwidth of the adaptive spatial kernel is estimated by optimizing the predictive power of the kernel estimate of the spatial earthquake density in retrospective forecasts. When available and trustworthy, we used small earthquakes m>2.95 to illuminate active fault structur...
Numerical quadrature over smooth surfaces with boundaries
Reeger, Jonah A.; Fornberg, Bengt
2018-02-01
This paper describes a high order accurate method to calculate integrals over curved surfaces with boundaries. Given data locations that are arbitrarily distributed over the surface, together with some functional description of the surface and its boundary, the algorithm produces matching quadrature weights. This extends on the authors' earlier methods for integrating over the surface of a sphere and over arbitrarily shaped smooth closed surfaces by also considering domain boundaries. The core approach consists again of combining RBF-FD (radial basis function-generated finite difference) approximations for curved surface triangles, which together make up the full surface. The provided examples include both curved and flat domains. In the highly special case of equi-spaced nodes over a regular interval in 1-D, the method provides a new opportunity for improving on the classical Gregory enhancements of the trapezoidal rule.
Smooth Pursuit of Flicker-Defined Motion
Mulligan, Jeffrey B.; Stevenson, Scott B.
2014-01-01
We examined the pursuit response to stimuli defined by space-variant flicker of a dense random dot carrier pattern. On each frame, every element of the pattern could change polarity, with a probability given by a two-dimensional Gaussian distribution. A normal distribution produces a circular region of twinkle, while inverting the distribution results in a spot of static texture in a twinkling surround. In this latter case, the carrier texture could be stationary, or could move with the twinkle modulator, thereby producing first-order motion in the region of the spot. While the twinkle-defined spot produces a strong sensation of motion, the complementary stimulus defined by the absence of twinkle does not, when viewed peripherally, it appears to move in steps even when the generating distribution moves smoothly. We examined pursuit responses to these stimuli using two techniques: 1) the eye movement correlogram, obtained by cross-correlating eye velocity with the velocity of a randomly-moving stimulus; and 2) delayed visual feedback, where transient stabilization of a target can produce spontaneous oscillations of the eye, with a period empirically observed to vary linearly with the applied delay. Both techniques provide an estimate of the internal processing time, which can be as short as 100 milliseconds for a first-order target. Assessed by the correlogram method, the response to flicker-defined motion is delayed by more than 100 milliseconds, and significantly weaker (especially in the vertical dimension). When initially presented in the delayed feedback condition, purely saccadic oscillation is observed. One subject eventually developed smooth oscillations (albeit with significant saccadic intrusions), showing a period-versus-delay slope similar to that observed for first-order targets. This result is somewhat surprising, given that we interpret the slope of the period-versus-delay-function as reflecting the balance between position- and velocity
Anisotropic Smoothing Improves DT-MRI-Based Muscle Fiber Tractography.
Directory of Open Access Journals (Sweden)
Amanda K W Buck
Full Text Available To assess the effect of anisotropic smoothing on fiber tracking measures, including pennation angle, fiber tract length, and fiber tract number in the medial gastrocnemius (MG muscle in healthy subjects using diffusion-weighted magnetic resonance imaging (DW-MRI.3T DW-MRI data were used for muscle fiber tractography in the MG of healthy subjects. Anisotropic smoothing was applied at three levels (5%, 10%, 15%, and pennation angle, tract length, fiber tract number, fractional anisotropy, and principal eigenvector orientation were quantified for each smoothing level.Fiber tract length increased with pre-fiber tracking smoothing, and local heterogeneities in fiber direction were reduced. However, pennation angle was not affected by smoothing.Modest anisotropic smoothing (10% improved fiber-tracking results, while preserving structural features.
Changes of smooth muscle contractile filaments in small bowel atresia
Gfrörer, Stefan; Fiegel, Henning; Ramachandran, Priya; Rolle, Udo; Metzger, Roman
2012-01-01
AIM: To investigate morphological changes of intestinal smooth muscle contractile fibres in small bowel atresia patients. METHODS: Resected small bowel specimens from small bowel atresia patients (n = 12) were divided into three sections (proximal, atretic and distal). Standard histology hematoxylin-eosin staining and enzyme immunohistochemistry was performed to visualize smooth muscle contractile markers α-smooth muscle actin (SMA) and desmin using conventional paraffin sections of the proxi...
Caveolin-3 promotes a vascular smooth muscle contractile phenotype
Directory of Open Access Journals (Sweden)
Jorge L. Gutierrez-Pajares
2015-06-01
Full Text Available Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of these illnesses. Vascular smooth muscle cells are key regulators of the vascular tone and also have an important function in the development of atherosclerosis and restenosis. While in the normal vasculature contractile smooth muscle cells are predominant, in atherosclerotic vascular lesions, synthetic cells migrate toward the neointima, proliferate, and synthetize extracellular matrix proteins. In the present study, we have examined the role of caveolin-3 in the regulation of smooth muscle cell phenotype. Caveolin-3 is expressed in vivo in normal arterial smooth muscle cells, but its expression appears to be lost in cultured smooth muscle cells. Our data show that caveolin-3 expression in the A7r5 smooth muscle cell line is associated with increased expression of contractility markers such as smooth muscle actin, smooth muscle myosin heavy chain but decreased expression of the synthetic phenotype markers such as p-Elk and Klf4. Moreover, we also show that caveolin-3 expression can reduce proliferation upon treatment with LDL or PDGF. Finally, we show that caveolin-3-expressing smooth muscle cells are less sensitive to apoptosis than control cells upon treatment with oxidized LDL. Taken together, our data suggest that caveolin-3 can regulate the phenotypic switch between contractile and synthetic smooth muscle cells. A better understanding of the factors regulating caveolin-3 expression and function in this cell type will permit the development of a better comprehension of the factors regulating smooth muscle function in atherosclerosis and restenosis.
Modifying the double smoothing bandwidth selector in nonparametric regression
Beran, Jan; Feng, Yuanhua; Heiler, Siegfried
2000-01-01
In this paper a modified double smoothing bandwidth selector, ^h MDS , based on a new criterion, which combines the plug-in and the double smoothing ideas, is proposed. A self-complete iterative double smoothing rule ( ^ h IDS ) is introduced as a pilot method. The asymptotic properties of both ^ h IDS and ^ h MDS are investigated. It is shown that ^ h MDS performs asymptotically very well. Moreover, it is asymptotically negatively correlated with h ASE , the minimizer of the averaged squared...
Recursive Robot-Arm Dynamics via Filtering and Smoothing
Rodriguez, Guillermo
1987-01-01
Forward and inverse dynamics solved using Kalman filtering and Bryson-Frazier smoothing. Dynamics of serial-link robot arm solved by using recursive techniques from linear filtering and smoothing theory. Solutions of dynamical equations give forces, moments, and accelerations at joints between links, and multilink inertia matrix and its inverse. Theoretical developments lay foundation for use of filtering and smoothing techniques in design of robot controls.
Robust forecasting with exponential and Holt-Winters smoothing.
Gelper, SEC Sarah; Fried, R; Croux, C.
2007-01-01
Robust versions of the exponential and Holt-Winters smoothing method for forecasting are presented. They are suitable for forecasting univariate time series in presence of outliers. The robust exponential and Holt-Winters smoothing methods are presented as a recursive updating scheme. Both the update equation and the selection of the smoothing parameters are robustied. This robust method is equivalent to a particular form of the robust Kalman lter in a local linear trend model. A simulation s...
Hydrochlorothiazide Potentiates Contractile Activity of Mouse Cavernosal Smooth Muscle
Directory of Open Access Journals (Sweden)
Thiago Gagliano-Jucá, MD, PhD
2016-06-01
Conclusion: Hydrochlorothiazide potentiates contraction of smooth muscle from mouse CC. These findings could explain why diuretics such as hydrochlorothiazide are associated with erectile dysfunction.
How Do Families Smooth Household Heads` Earnings Volatility?
National Research Council Canada - National Science Library
Ki Seong Park;
2010-01-01
We investigate the extent to which household heads` earnings volatility is translated into household consumption volatility, and, in the process, identify measures of smoothing idiosyncratic earnings variation...
I-spline Smoothing for Calibrating Predictive Models.
Wu, Yuan; Jiang, Xiaoqian; Kim, Jihoon; Ohno-Machado, Lucila
2012-01-01
We proposed the I-spline Smoothing approach for calibrating predictive models by solving a nonlinear monotone regression problem. We took advantage of I-spline properties to obtain globally optimal solutions while keeping the computational cost low. Numerical studies based on three data sets showed the empirical evidences of I-spline Smoothing in improving calibration (i.e.,1.6x, 1.4x, and 1.4x on the three datasets compared to the average of competitors-Binning, Platt Scaling, Isotonic Regression, Monotone Spline Smoothing, Smooth Isotonic Regression) without deterioration of discrimination.
Zhang, Rong; Jack, Gregory S; Rao, Nagesh; Zuk, Patricia; Ignarro, Louis J; Wu, Benjamin; Rodríguez, Larissa V
2012-03-01
Human adipose-derived stem cells hASC have been isolated and were shown to have multilineage differentiation capacity. Although both plasticity and cell fusion have been suggested as mechanisms for cell differentiation in vivo, the effect of the local in vivo environment on the differentiation of adipose-derived stem cells has not been evaluated. We previously reported the in vitro capacity of smooth muscle differentiation of these cells. In this study, we evaluate the effect of an in vivo smooth muscle environment in the differentiation of hASC. We studied this by two experimental designs: (a) in vivo evaluation of smooth muscle differentiation of hASC injected into a smooth muscle environment and (b) in vitro evaluation of smooth muscle differentiation capacity of hASC exposed to bladder smooth muscle cells. Our results indicate a time-dependent differentiation of hASC into mature smooth muscle cells when these cells are injected into the smooth musculature of the urinary bladder. Similar findings were seen when the cells were cocultured in vitro with primary bladder smooth muscle cells. Chromosomal analysis demonstrated that microenvironment cues rather than nuclear fusion are responsible for this differentiation. We conclude that cell plasticity is present in hASCs, and their differentiation is accomplished in the absence of nuclear fusion. Copyright © 2011 AlphaMed Press.
Microwave susceptibility experiments
Energy Technology Data Exchange (ETDEWEB)
McConaghy, C.
1984-05-29
In certain experimental environments, systems can be affected or damaged by microwave pulses. I have conducted tests at LLNL to understand the phenomenology of microwave susceptibility of system components and subsystem components. To date, my experiments have concentrated on bipolar transistors, similar to what might be used in discrete analog circuits, and on CMOS RAM chips, which might be used in a computer memory system. I observed a decrease in failure energies for both the transistor and the integrated curcuit as I shortened the microwave pulse width. An S band (2.86 GHz) transmit/receive (T/R) tube has also been tested both at S band and at X band (8.16 GHz). The S band pulse had limitations in rise-time from zero power, which had an effect on the amount of power that could be transmitted through the T/R tube, as much as 0.7% of the incident power passed through the tube. All tests were conducted in closed-waveguide or coax test-fixtures, in contrast to the anechoic chambers utilized by other experimenters. I have used both S band and X band Klystron generators. For very high power (greater than 1 MW), I used an additional pulse-compression cavity at S band. Other subsystem components such as an X band mixer and an X band T/R tube will be tested in the future. 8 references.
[Antimicrobial susceptibility cumulative reports].
Canut-Blasco, Andrés; Calvo, Jorge; Rodríguez-Díaz, Juan Carlos; Martínez-Martínez, Luis
2016-10-01
Cumulative reports on antimicrobial susceptibility tests data are important for selecting empirical treatments, as an educational tool in programs on antimicrobial use, and for establishing breakpoints defining clinical categories. These reports should be based on data validated by clinical microbiologists using diagnostic samples (not surveillance samples). In order to avoid a bias derived from including several isolates obtained from the same patient, it is recommended that, for a defined period, only the first isolate is counted. A minimal number of isolates per species should be presented: a figure of >=30 isolates is statistically acceptable. The report is usually presented in a table format where, for each cell, information on clinically relevant microorganisms-antimicrobial agents is presented. Depending on particular needs, multiple tables showing data related to patients, samples, services or special pathogens can be prepared. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
An implicit Smooth Particle Hydrodynamic code
Energy Technology Data Exchange (ETDEWEB)
Knapp, Charles E. [Univ. of New Mexico, Albuquerque, NM (United States)
2000-05-01
An implicit version of the Smooth Particle Hydrodynamic (SPH) code SPHINX has been written and is working. In conjunction with the SPHINX code the new implicit code models fluids and solids under a wide range of conditions. SPH codes are Lagrangian, meshless and use particles to model the fluids and solids. The implicit code makes use of the Krylov iterative techniques for solving large linear-systems and a Newton-Raphson method for non-linear corrections. It uses numerical derivatives to construct the Jacobian matrix. It uses sparse techniques to save on memory storage and to reduce the amount of computation. It is believed that this is the first implicit SPH code to use Newton-Krylov techniques, and is also the first implicit SPH code to model solids. A description of SPH and the techniques used in the implicit code are presented. Then, the results of a number of tests cases are discussed, which include a shock tube problem, a Rayleigh-Taylor problem, a breaking dam problem, and a single jet of gas problem. The results are shown to be in very good agreement with analytic solutions, experimental results, and the explicit SPHINX code. In the case of the single jet of gas case it has been demonstrated that the implicit code can do a problem in much shorter time than the explicit code. The problem was, however, very unphysical, but it does demonstrate the potential of the implicit code. It is a first step toward a useful implicit SPH code.
An Improved Sequential Smoothing Particle Filtering Method
Directory of Open Access Journals (Sweden)
Cao Shijie
2017-01-01
Full Text Available In order to cope with the challenges of non-cooperative targets such as stealth targets to modern radar, especially when traditional threshold detection and tracking methods can hardly detect fast-moving stealth targets, technological innovation has long been required. In this paper we have proposed a new algorithm which can reduce computational cost and improve tracking accuracy. Firstly, the number of particles in the traditional particle filter is reduced and a small number of sampling points are derived from the possible distribution of the target to be tracked, each given a proper weight. Then, the transformed sampling points are sequentially smoothed. And finally, the target positions are estimated. The simulation results show that the proposed algorithm is more accurate than the traditional particle filter algorithm and has lower computational complexity. In the case when SNR is between 0dB to 15dB, a total of 100 Monte Carlo simulations are carried out, obtaining a high detection probability. The detection probability of the improved algorithm is higher than that of the existing particle filter at 7dB. Also, the computational cost is lower than the existing particle filter algorithm.
Drop splash on a smooth, dry surface
Riboux, Guillaume; Gordillo, Jose Manuel; Korobkin, Alexander
2013-11-01
It is our purpose here to determine the conditions under which a drop of a given liquid with a known radius R impacting against a smooth impermeable surface at a velocity V, will either spread axisymmetrically onto the substrate or will create a splash, giving rise to usually undesired star-shaped patterns. In our experimental setup, drops are generated injecting low viscosity liquids falling under the action of gravity from a stainless steel hypodermic needle. The experimental observations using two high speed cameras operating simultaneously and placed perpendicularly to each other reveal that, initially, the drop deforms axisymmetrically, with A (T) the radius of the wetted area. For high enough values of the drop impact velocity, a thin sheet of liquid starts to be ejected from A (T) at a velocity Vjet > V for instants of time such that T >=Tc . If Vjet is above a certain threshold, which depends on the solid wetting properties as well as on the material properties of both the liquid and the atmospheric gas, the rim of the lamella dewets the solid to finally break into drops. Using Wagner's theory we demonstrate that A (T) =√{ 3 RVT } and our results also reveal that Tc We - 1 / 2 =(ρV2 R / σ) - 1 / 2 and Vjet We 1 / 4 .
Dynamics of wetting on smooth and rough surfaces.
Cazabat, A.M.; Cohen Stuart, M.A.
1987-01-01
The rate of spreading of non-volatile liquids on smooth and on rough surfaces was investigated. The radius of the wetted spot was found to agree with recently proposed scaling laws (t 1/10 for capillarity driven andt 1/8 for gravity driven spreading) when the surface was smooth. However, the
Three-phase electric drive with modified electronic smoothing inductor
DEFF Research Database (Denmark)
Singh, Yash Veer; Rasmussen, Peter Omand; Andersen, Torben Ole
2010-01-01
This paper presents a three-phase electric drive with a modified electronic smoothing inductor (MESI) having reduced size of passive components. The classical electronic smoothing inductor (ESI) is able to control a diode bridge output current and also reduce not only mains current harmonics...
Genetic Programming with Smooth Operators for Arithmetic Expressions
DEFF Research Database (Denmark)
Ursem, Rasmus Kjær; Krink, Thiemo
2002-01-01
This paper introduces the smooth operators for arithmetic expressions as an approach to smoothening the search space in Genetic Programming (GP). Smooth operator GP interpolates between arithmetic operators such as * and /, thereby allowing a gradual adaptation to the problem. The suggested...
Altered extracellular magnesium and variations in vascular smooth ...
African Journals Online (AJOL)
Background: There is a paucity of information on the heterogeneity of vascular smooth muscles in their responses to agonists following exposure to varying extracellular magnesium, [Mg2+]0. The present study was designed to examine, comparatively, the influence of variations in [Mg2+]0 on vascular smooth muscles of ...
Estimate of K-functionals and modulus of smoothness constructed ...
Indian Academy of Sciences (India)
Using a generalized spherical mean operator, we define generalized modulus of smoothness in the space L k 2 ( R d ) . Based on the Dunkl operator we define Sobolev-type space and -functionals. The main result of the paper is the proof of the equivalence theorem for a -functional and a modulus of smoothness for the ...
Smooth surfaces from bilinear patches: Discrete affine minimal surfaces
Käferböck, Florian
2013-06-01
Motivated by applications in freeform architecture, we study surfaces which are composed of smoothly joined bilinear patches. These surfaces turn out to be discrete versions of negatively curved affine minimal surfaces and share many properties with their classical smooth counterparts. We present computational design approaches and study special cases which should be interesting for the architectural application. 2013 Elsevier B.V.
Bandwidth selection in smoothing functions | Kibua | East African ...
African Journals Online (AJOL)
... inexpensive and, hence, worth adopting. We argue that the bandwidth parameter is determined by two factors: the kernel function and the length of the smoothing region. We give an illustrative example of its application using real data. Keywords: Kernel, Smoothing functions, Bandwidth > East African Journal of Statistics ...
Smooth maps of a foliated manifold in a symplectic manifold
Indian Academy of Sciences (India)
Let be a smooth manifold with a regular foliation F and a 2-form which induces closed forms on the leaves of F in the leaf topology. A smooth map f : ( M , F ) ⟶ ( N , ) in a symplectic manifold ( N , ) is called a foliated symplectic immersion if restricts to an immersion on each leaf of the foliation and further, the ...
A Monte-Carlo weighted moving average process for smoothing ...
African Journals Online (AJOL)
A Monte-Carlo weighted moving average process for smoothing time series data. N Ekhosuehi, DEA Omorogbe. Abstract. A Monte-Carlo weighted moving average procedure was developed for smoothing time series data. The applicability of the method was demonstrated by using two economic time series data set to ...
Airway structural components drive airway smooth muscle remodeling in asthma
Dekkers, Bart G J; Maarsingh, Harm; Meurs, Herman; Gosens, Reinoud
2009-01-01
Chronic asthma is an inflammatory airways disease characterized by pathological changes in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and hyperresponsiveness. Remodeling of the ASM is associated with an increased smooth muscle mass, involving components of cellular
A generalized relative total variation method for image smoothing
Liu, Qiegen; Xiong, Biao; Yang, Dingcheng; Zhang, Minghui
2016-01-01
Recently, two piecewise smooth models L0smoothing and relative total variation (RTV) have been proposed for feature/structure-preserving filtering. One is very efficient for tackling image with little texture patterns and the other has appearance performance on image with abundant uniform textural
On smoothed analysis of quicksort and Hoare's find
Fouz, Mahmoud; Kufleitner, Manfred; Manthey, Bodo; Zeini Jahromi, Nima; Ngo, H.Q.
2009-01-01
We provide a smoothed analysis of Hoare’s find algorithm and we revisit the smoothed analysis of quicksort. Hoare’s find algorithm – often called quickselect – is an easy-to-implement algorithm for finding the $k$-th smallest element of a sequence. While the worst-case number of comparisons that
Dissimilarity for functional data clustering based on smoothing parameter commutation.
Tzeng, ShengLi; Hennig, Christian; Li, Yu-Fen; Lin, Chien-Ju
2017-01-01
Many studies measure the same type of information longitudinally on the same subject at multiple time points, and clustering of such functional data has many important applications. We propose a novel and easy method to implement dissimilarity measure for functional data clustering based on smoothing splines and smoothing parameter commutation. This method handles data observed at regular or irregular time points in the same way. We measure the dissimilarity between subjects based on varying curve estimates with pairwise commutation of smoothing parameters. The intuition is that smoothing parameters of smoothing splines reflect the inverse of the signal-to-noise ratios and that when applying an identical smoothing parameter the smoothed curves for two similar subjects are expected to be close. Our method takes into account the estimation uncertainty using smoothing parameter commutation and is not strongly affected by outliers. It can also be used for outlier detection. The effectiveness of our proposal is shown by simulations comparing it to other dissimilarity measures and by a real application to methadone dosage maintenance levels.
Regeneration and Maintenance of Intestinal Smooth Muscle Phenotypes
Walthers, Christopher M.
Tissue engineering is an emerging field of biomedical engineering that involves growing artificial organs to replace those lost to disease or injury. Within tissue engineering, there is a demand for artificial smooth muscle to repair tissues of the digestive tract, bladder, and vascular systems. Attempts to develop engineered smooth muscle tissues capable of contracting with sufficient strength to be clinically relevant have so far proven unsatisfactory. The goal of this research was to develop and sustain mature, contractile smooth muscle. Survival of implanted SMCs is critical to sustain the benefits of engineered smooth muscle. Survival of implanted smooth muscle cells was studied with layered, electrospun polycaprolactone implants with lasercut holes ranging from 0--25% porosity. It was found that greater angiogenesis was associated with increased survival of implanted cells, with a large increase at a threshold between 20% and 25% porosity. Heparan sulfate coatings improved the speed of blood vessel infiltration after 14 days of implantation. With these considerations, thicker engineered tissues may be possible. An improved smooth muscle tissue culture technique was utilized. Contracting smooth muscle was produced in culture by maintaining the native smooth muscle tissue organization, specifically by sustaining intact smooth muscle strips rather than dissociating tissue in to isolated smooth muscle cells. Isolated cells showed a decrease in maturity and contained fewer enteric neural and glial cells. Muscle strips also exhibited periodic contraction and regular fluctuation of intracellular calclium. The muscle strip maturity persisted after implantation in omentum for 14 days on polycaprolactone scaffolds. A low-cost, disposable bioreactor was developed to further improve maturity of cultured smooth muscle cells in an environment of controlled cyclical stress.The bioreactor consistently applied repeated mechanical strain with controllable inputs for strain
LUM Smoother with Smooth Control for Noisy Image Sequences
Directory of Open Access Journals (Sweden)
Lukàč Rastislav
2001-01-01
Full Text Available This paper focuses on adaptive structure of LUM (lower-upper-middle smoothers for noisy image sequences. For the balance between noise suppression and signal-detail preservation, the LUM smoothers are widely used in smoothing applications. The amount of smoothing done by LUM smoothers is controlled by tuning parameter. However, the smoothing level is fixed for whole image. Thus, the excessive or insufficient smoothing can be performed. This problem is solved by a new method based on the adaptive controlled level of smoothing. A new method has excellent performance of the noise reduction in the environments corrupted by the impulse noise. In addition, minimal signal-detail and motion blurring can be observed. The performance of proposed method is evaluated through objective criteria and compared with traditional temporal, spatial, and spatiotemporal LUM smoothers.
Moving least-squares corrections for smoothed particle hydrodynamics
Directory of Open Access Journals (Sweden)
Ciro Del Negro
2011-12-01
Full Text Available First-order moving least-squares are typically used in conjunction with smoothed particle hydrodynamics in the form of post-processing filters for density fields, to smooth out noise that develops in most applications of smoothed particle hydrodynamics. We show how an approach based on higher-order moving least-squares can be used to correct some of the main limitations in gradient and second-order derivative computation in classic smoothed particle hydrodynamics formulations. With a small increase in computational cost, we manage to achieve smooth density distributions without the need for post-processing and with higher accuracy in the computation of the viscous term of the Navier–Stokes equations, thereby reducing the formation of spurious shockwaves or other streaming effects in the evolution of fluid flow. Numerical tests on a classic two-dimensional dam-break problem confirm the improvement of the new approach.
The effect of robot dynamics on smoothness during wrist pointing.
Erwin, Andrew; Pezent, Evan; Bradley, Joshua; O'Malley, Marcia K
2017-07-01
The improvement of movement smoothness over the course of therapy is one of the positive outcomes observed during robotic rehabilitation. Although movements are generally robust to disturbances, certain perturbations might disrupt an individual's ability to produce these smooth movements. In this paper, we explore how a rehabilitation robot's inherent dynamics impact movement smoothness during pointing tasks. Able-bodied participants made wrist pointing movements under four different operating conditions. Despite the relative transparency of the device, inherent dynamic characteristics negatively impacted movement smoothness. Active compensation for Coulomb friction effects failed to mitigate the degradation in smoothness. Assessment of movements that involved coupled motions of the robot's joints reduced the bias seen in single degree of freedom movements. When using robotic devices for assessment of movement quality, the impact of the inherent dynamics must be considered.
[Antimicrobial susceptibility in Chile 2012].
Cifuentes-D, Marcela; Silva, Francisco; García, Patricia; Bello, Helia; Briceño, Isabel; Calvo-A, Mario; Labarca, Jaime
2014-04-01
Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.
ON THE DERIVATIVE OF SMOOTH MEANINGFUL FUNCTIONS
Directory of Open Access Journals (Sweden)
Sanjo Zlobec
2011-02-01
Full Text Available The derivative of a function f in n variables at a point x* is one of the most important tools in mathematical modelling. If this object exists, it is represented by the row n-tuple f(x* = [∂f/∂xi(x*] called the gradient of f at x*, abbreviated: “the gradient”. The evaluation of f(x* is usually done in two stages, first by calculating the n partials and then their values at x = x*. In this talk we give an alternative approach. We show that one can characterize the gradient without differentiation! The idea is to fix an arbitrary row n-tuple G and answer the following question: What is a necessary and sufficient condition such that G is the gradient of a given f at a given x*? The answer is given after adjusting the quadratic envelope property introduced in [3]. We work with smooth, i.e., continuously differentiable, functions with a Lipschitz derivative on a compact convex set with a non-empty interior. Working with this class of functions is not a serious restriction. In fact, loosely speaking, “almost all” smooth meaningful functions used in modelling of real life situations are expected to have a bounded “acceleration” hence they belong to this class. In particular, the class contains all twice differentiable functions [1]. An important property of the functions from this class is that every f can be represented as the difference of some convex function and a convex quadratic function. This decomposition was used in [3] to characterize the zero derivative points. There we obtained reformulations and augmentations of some well known classic results on optimality such as Fermats extreme value theorem (known from high school and the Lagrange multiplier theorem from calculus [2, 3]. In this talk we extend the results on zero derivative points to characterize the relation G = f(x*, where G is an arbitrary n-tuple. Some special cases: If G = O, we recover the results on zero derivative points. For functions of a single
Adaptively smoothed seismicity earthquake forecasts for Italy
Directory of Open Access Journals (Sweden)
Yan Y. Kagan
2010-11-01
Full Text Available We present a model for estimation of the probabilities of future earthquakes of magnitudes m ≥ 4.95 in Italy. This model is a modified version of that proposed for California, USA, by Helmstetter et al. [2007] and Werner et al. [2010a], and it approximates seismicity using a spatially heterogeneous, temporally homogeneous Poisson point process. The temporal, spatial and magnitude dimensions are entirely decoupled. Magnitudes are independently and identically distributed according to a tapered Gutenberg-Richter magnitude distribution. We have estimated the spatial distribution of future seismicity by smoothing the locations of past earthquakes listed in two Italian catalogs: a short instrumental catalog, and a longer instrumental and historic catalog. The bandwidth of the adaptive spatial kernel is estimated by optimizing the predictive power of the kernel estimate of the spatial earthquake density in retrospective forecasts. When available and reliable, we used small earthquakes of m ≥ 2.95 to reveal active fault structures and 29 probable future epicenters. By calibrating the model with these two catalogs of different durations to create two forecasts, we intend to quantify the loss (or gain of predictability incurred when only a short, but recent, data record is available. Both forecasts were scaled to five and ten years, and have been submitted to the Italian prospective forecasting experiment of the global Collaboratory for the Study of Earthquake Predictability (CSEP. An earlier forecast from the model was submitted by Helmstetter et al. [2007] to the Regional Earthquake Likelihood Model (RELM experiment in California, and with more than half of the five-year experimental period over, the forecast has performed better than the others.
Bronchial Smooth Muscle Remodeling in Nonsevere Asthma.
Girodet, Pierre-Olivier; Allard, Benoit; Thumerel, Matthieu; Begueret, Hugues; Dupin, Isabelle; Ousova, Olga; Lassalle, Régis; Maurat, Elise; Ozier, Annaig; Trian, Thomas; Marthan, Roger; Berger, Patrick
2016-03-15
Increased bronchial smooth muscle (BSM) mass is a key feature of airway remodeling that classically distinguishes severe from nonsevere asthma. Proliferation of BSM cells involves a specific mitochondria-dependent pathway in individuals with severe asthma. However, BSM remodeling and mitochondrial biogenesis have not been examined in nonsevere asthma. We aimed to assess whether an increase in BSM mass was also implicated in nonsevere asthma and its relationship with mitochondria and clinical outcomes. We enrolled 34 never-smoker subjects with nonsevere asthma. In addition, we recruited 56 subjects with nonsevere asthma and 19 subjects with severe asthma as comparative groups (COBRA cohort [Cohorte Obstruction Bronchique et Asthme; Bronchial Obstruction and Asthma Cohort; sponsored by the French National Institute of Health and Medical Research, INSERM]). A phenotypic characterization was performed using questionnaires, atopy and pulmonary function testing, exhaled nitric oxide measurement, and blood collection. Bronchial biopsy specimens were processed for immunohistochemistry and electron microscopy analysis. After BSM remodeling assessment, subjects were monitored over a 12-month period. We identified characteristic features of remodeling (BSM area >26.6%) and increased mitochondrial number within BSM in a subgroup of subjects with nonsevere asthma. The number of BSM mitochondria was positively correlated with BSM area (r = 0.78; P asthma with high BSM had worse asthma control and a higher rate of exacerbations per year compared with subjects with low BSM. This study reveals that BSM remodeling and mitochondrial biogenesis may play a critical role in the natural history of nonsevere asthma (Mitasthme study). Clinical trial registered with www.clinicaltrials.gov (NCT00808730).
pso.ATION AND ANTIMICROBIAL SUSCEPTIBILITY
African Journals Online (AJOL)
isolates vere made using standard methods, Antibiotic susceptibility tests against commonly prescribed ... Acute otitis media is rapid with short .... sensitivity tests. Antimicrobial susceptibility tests: The antimicrobial susceptibility patterns of major Gram positive and negative bacterial isolates obtained from clinical specimens.
Hypnotic susceptibility and dream characteristics.
Zamore, N; Barrett, D
1989-11-01
This study examined the relationship of hypnotic susceptibility to a variety of dream characteristics and types of dream content. A Dream Questionnaire was constructed synthesizing Gibson's dream inventory and Hilgard's theoretical conceptions of hypnosis. Employing the Harvard Group Scale of Hypnotic Susceptibility and the Field Inventory for evaluating hypnotic response, several dream dimensions correlated significantly with hypnotizability. For subjects as a whole, the strongest correlates were the frequency of dreams which they believed to be precognitive and out-of-body dreams. Ability to dream on a chosen topic also correlated significantly with hypnotic susceptibility for both genders. For females only, there was a negative correlation of hypnotic susceptibility to flying dreams. Absorption correlated positively with dream recall, ability to dream on a chosen topic, reports of conflict resolution in dreams, creative ideas occurring in dreams, amount of color in dreams, pleasantness of dreams, bizarreness of dreams, flying dreams and precognitive dreams.
An invertebrate smooth muscle with striated muscle myosin filaments
Sulbarán, Guidenn; Alamo, Lorenzo; Pinto, Antonio; Márquez, Gustavo; Méndez, Franklin; Padrón, Raúl; Craig, Roger
2015-01-01
Muscle tissues are classically divided into two major types, depending on the presence or absence of striations. In striated muscles, the actin filaments are anchored at Z-lines and the myosin and actin filaments are in register, whereas in smooth muscles, the actin filaments are attached to dense bodies and the myosin and actin filaments are out of register. The structure of the filaments in smooth muscles is also different from that in striated muscles. Here we have studied the structure of myosin filaments from the smooth muscles of the human parasite Schistosoma mansoni. We find, surprisingly, that they are indistinguishable from those in an arthropod striated muscle. This structural similarity is supported by sequence comparison between the schistosome myosin II heavy chain and known striated muscle myosins. In contrast, the actin filaments of schistosomes are similar to those of smooth muscles, lacking troponin-dependent regulation. We conclude that schistosome muscles are hybrids, containing striated muscle-like myosin filaments and smooth muscle-like actin filaments in a smooth muscle architecture. This surprising finding has broad significance for understanding how muscles are built and how they evolved, and challenges the paradigm that smooth and striated muscles always have distinctly different components. PMID:26443857
Smooth pursuit eye movements and schizophrenia: literature review.
Franco, J G; de Pablo, J; Gaviria, A M; Sepúlveda, E; Vilella, E
2014-09-01
To review the scientific literature about the relationship between impairment on smooth pursuit eye movements and schizophrenia. Narrative review that includes historical articles, reports about basic and clinical investigation, systematic reviews, and meta-analysis on the topic. Up to 80% of schizophrenic patients have impairment of smooth pursuit eye movements. Despite the diversity of test protocols, 65% of patients and controls are correctly classified by their overall performance during this pursuit. The smooth pursuit eye movements depend on the ability to anticipate the target's velocity and the visual feedback, as well as on learning and attention. The neuroanatomy implicated in smooth pursuit overlaps to some extent with certain frontal cortex zones associated with some clinical and neuropsychological characteristics of the schizophrenia, therefore some specific components of smooth pursuit anomalies could serve as biomarkers of the disease. Due to their sedative effect, antipsychotics have a deleterious effect on smooth pursuit eye movements, thus these movements cannot be used to evaluate the efficacy of the currently available treatments. Standardized evaluation of smooth pursuit eye movements on schizophrenia will allow to use specific aspects of that pursuit as biomarkers for the study of its genetics, psychopathology, or neuropsychology. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.
Efficient computation of smoothing splines via adaptive basis sampling
Ma, Ping
2015-06-24
© 2015 Biometrika Trust. Smoothing splines provide flexible nonparametric regression estimators. However, the high computational cost of smoothing splines for large datasets has hindered their wide application. In this article, we develop a new method, named adaptive basis sampling, for efficient computation of smoothing splines in super-large samples. Except for the univariate case where the Reinsch algorithm is applicable, a smoothing spline for a regression problem with sample size n can be expressed as a linear combination of n basis functions and its computational complexity is generally O(n^{3}). We achieve a more scalable computation in the multivariate case by evaluating the smoothing spline using a smaller set of basis functions, obtained by an adaptive sampling scheme that uses values of the response variable. Our asymptotic analysis shows that smoothing splines computed via adaptive basis sampling converge to the true function at the same rate as full basis smoothing splines. Using simulation studies and a large-scale deep earth core-mantle boundary imaging study, we show that the proposed method outperforms a sampling method that does not use the values of response variables.
Ancestral susceptibility to colorectal cancer
Czech Academy of Sciences Publication Activity Database
Huhn, S.; Pardini, Barbara; Naccarati, Alessio; Vodička, Pavel (ed.); Hemminki, K.; Försti, A.
2012-01-01
Roč. 27, č. 2 (2012), s. 197-204 ISSN 0267-8357 R&D Projects: GA ČR GA310/07/1430; GA ČR GAP304/10/1286 Grant - others:EU FP7(XE) HEALTH-F4-2007-200767 Institutional research plan: CEZ:AV0Z50390512 Keywords : cancer susceptibility * molecular epidemiology * genetic susceptibility Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.500, year: 2012
Super-smooth polishing on aspherical surfaces (II): achievement of a super-smooth polishing
Ando, Manabu; Negishi, Mahito; Takimoto, Masafumi; Deguchi, Akinobu; Nakamura, Nobuo
1995-08-01
This paper discusses super-smooth polishing technology for excimer lasers, soft X-rays, and other short-wavelength light applications. Short-wavelength light elements require surface quality and contour accuracy superior to traditional specifications, as well as free-form contours. For this reason, our target for free-form contours of a 500 mm diameter was set to 0.08 mm PV for contour accuracy, and 0.2 nm RMS for surface roughness. To improve surface quality we employed local pitch polishing, utilizing a flexible tool laminated with an elastic sheet, which adapts well to various contours. For greater contour accuracy, we developed the CSSP (Canon Super-Smooth Polisher), which polishes 500 mm diameter optical elements. The CSSP polishing process achieves a contour accuracy of 0.078 mm PV and a surface roughness of 0.13 nm RMS on a 500 mm diameter fused silica toroidal mirror. We also fabricated both CaF2 and CVD-SiC, materials widely used in short-wavelength light elements.
Smooth muscle phenotypic modulation--a personal experience.
Campbell, Julie H; Campbell, Gordon R
2012-08-01
The idea that smooth muscle cells can exist in multiple phenotypic states depending on the functional demands placed upon them has been around for >5 decades. However, much of the literature today refers to only recent articles, giving the impression that it is a new idea. At the same time, the current trend is to delve deeper and deeper into transcriptional regulation of smooth muscle genes, and much of the work describing the change in biology of the cells in the different phenotypic states does not appear to be known. This loss of historical perspective regarding the biology of smooth muscle phenotypic modulation is what the current article has tried to mitigate.
Stabilizing S.P.H. with conservative smoothing
Energy Technology Data Exchange (ETDEWEB)
Wen, Y.; Hicks, D.L. [Michigan Tech. Univ., Houghton, MI (United States); Swegle, J.W. [Sandia National Labs., Albuquerque, NM (United States)
1994-08-01
There is an instability in certain S.P.H. (Smoothed Particle Hydrodynamics method) material dynamics computations. Evidence from analyses and experiments suggests that the instabilities in S.P.H. are not removable with artificial viscosities. However, the analysis shows that a type of conservative smoothing does remove the instability. Also, numerical experiments, on certain test problems, show that SPHCS, and S.P.H. code with conservative smoothing, compares well in accuracy with computations based on the von Neumann-Richtmyer method.
EXCHANGE-RATES FORECASTING: EXPONENTIAL SMOOTHING TECHNIQUES AND ARIMA MODELS
Directory of Open Access Journals (Sweden)
Dezsi Eva
2011-07-01
Full Text Available Exchange rates forecasting is, and has been a challenging task in finance. Statistical and econometrical models are widely used in analysis and forecasting of foreign exchange rates. This paper investigates the behavior of daily exchange rates of the Romanian Leu against the Euro, United States Dollar, British Pound, Japanese Yen, Chinese Renminbi and the Russian Ruble. Smoothing techniques are generated and compared with each other. These models include the Simple Exponential Smoothing technique, as the Double Exponential Smoothing technique, the Simple Holt-Winters, the Additive Holt-Winters, namely the Autoregressive Integrated Moving Average model.
A wave smoothing algorithm and applications to the financial markets
National Research Council Canada - National Science Library
Omar Ait Hellal; Gerald H Meyer
2014-01-01
In this paper we present an algorithm that can be implemented recursively or iteratively, to smooth waves by filtering out "noise" until the base case is reached, a canonical form that we call the wave's imprint...
Calcium-sensitivity of smooth muscle contraction in the isolated ...
African Journals Online (AJOL)
sensitivity of smooth muscle contraction were studied in the isolated perfused rat tail artery, employing the activators noradrenaline (NA) (3ìM) sand potassium chloride (KC1) (100mM). Experiments were conduced in Ca2+ - buffered saline.
Modeling Free-surface Solitary Waves with Smoothed Particle Hydrodynamics
National Research Council Canada - National Science Library
Balázs Tóth
2017-01-01
A three-dimensional weakly compressible Smoothed Particle Hydrodynamics (SPH) solver is presented and applied to simulate free-surface solitary waves generated in a quasi two dimensional dam-break experiment...
Iterative Bias Reduction Multivariate Smoothing in R: The ibr Package
Directory of Open Access Journals (Sweden)
Pierre-André Cornillon
2017-05-01
Full Text Available In multivariate nonparametric analysis curse of dimensionality forces one to use large smoothing parameters. This leads to a biased smoother. Instead of focusing on optimally selecting the smoothing parameter, we fix it to some reasonably large value to ensure an over-smoothing of the data. The resulting base smoother has a small variance but a substantial bias. In this paper, we propose an R package named ibr to iteratively correct the initial bias of the (base estimator by an estimate of the bias obtained by smoothing the residuals. After a brief description of iterated bias reduction smoothers, we examine the base smoothers implemented in the package: Nadaraya-Watson kernel smoothers, Duchon splines smoothers and their low rank counterparts. Then, we explain the stopping rules available in the package and their implementation. Finally we illustrate the package on two examples: a toy example in R2 and the original Los Angeles ozone dataset.
Functional consequences of human airway smooth muscle phenotype plasticity
Dekkers, Bart G J; Bos, I Sophie T; Zaagsma, Johan; Meurs, Herman
BACKGROUND AND PURPOSE: Airway smooth muscle (ASM) phenotype plasticity, characterized by reversible switching between contractile and proliferative phenotypes, is considered to contribute to increased ASM mass and airway hyper-responsiveness in asthma. Further, increased expression of collagen I
Derivatives of Multivariate Bernstein Operators and Smoothness with Jacobi Weights
Directory of Open Access Journals (Sweden)
Jianjun Wang
2012-01-01
Full Text Available Using the modulus of smoothness, directional derivatives of multivariate Bernstein operators with weights are characterized. The obtained results partly generalize the corresponding ones for multivariate Bernstein operators without weights.
A robust Kalman framework with resampling and optimal smoothing
National Research Council Canada - National Science Library
Kautz, Thomas; Eskofier, Bjoern M
2015-01-01
.... We introduce a novel Kalman-based analysis procedure that encompasses robustness towards outliers, Kalman smoothing and real-time conversion from non-uniformly sampled inputs to a constant output rate...
Estimation of UAV Position with Use of Smoothing Algorithms
Directory of Open Access Journals (Sweden)
Kaniewski Piotr
2017-03-01
Full Text Available The paper presents methods of on-line and off-line estimation of UAV position on the basis of measurements from its integrated navigation system. The navigation system installed on board UAV contains an INS and a GNSS receiver. The UAV position, as well as its velocity and orientation are estimated with the use of smoothing algorithms. For off-line estimation, a fixed-interval smoothing algorithm has been applied. On-line estimation has been accomplished with the use of a fixed-lag smoothing algorithm. The paper includes chosen results of simulations demonstrating improvements of accuracy of UAV position estimation with the use of smoothing algorithms in comparison with the use of a Kalman filter.
Interference between smooth pursuit and color working memory
Yue, Shulin; Jin, Zhenlan; Fan, Chenggui; Zhang, Qian; Li, Ling
2017-01-01
Spatial working memory (WM) and spatial attention are closely related, but the relationship between non-spatial WM and spatial attention still remains unclear. The present study aimed to investigate the interaction between color WM and smooth pursuit eye movements. A modified delayed-match-to-sample paradigm (DMS) was applied with 2 or 4 items presented in each visual field. Subjects memorized the colors of items in the cued visual field and smoothly moved eyes towards or away from memorized ...
Ureter smooth muscle cell orientation in rat is predominantly longitudinal.
Spronck, Bart; Merken, Jort J; Reesink, Koen D; Kroon, Wilco; Delhaas, Tammo
2014-01-01
In ureter peristalsis, the orientation of the contracting smooth muscle cells is essential, yet current descriptions of orientation and composition of the smooth muscle layer in human as well as in rat ureter are inconsistent. The present study aims to improve quantification of smooth muscle orientation in rat ureters as a basis for mechanistic understanding of peristalsis. A crucial step in our approach is to use two-photon laser scanning microscopy and image analysis providing objective, quantitative data on smooth muscle cell orientation in intact ureters, avoiding the usual sectioning artifacts. In 36 rat ureter segments, originating from a proximal, middle or distal site and from a left or right ureter, we found close to the adventitia a well-defined longitudinal smooth muscle orientation. Towards the lamina propria, the orientation gradually became slightly more disperse, yet the main orientation remained longitudinal. We conclude that smooth muscle cell orientation in rat ureter is predominantly longitudinal, though the orientation gradually becomes more disperse towards the proprial side. These findings do not support identification of separate layers. The observed longitudinal orientation suggests that smooth muscle contraction would rather cause local shortening of the ureter, than cause luminal constriction. However, the net-like connective tissue of the ureter wall may translate local longitudinal shortening into co-local luminal constriction, facilitating peristalsis. Our quantitative, minimally invasive approach is a crucial step towards more mechanistic insight into ureter peristalsis, and may also be used to study smooth muscle cell orientation in other tube-like structures like gut and blood vessels.
Smooth maps of a foliated manifold in a symplectic manifold
Indian Academy of Sciences (India)
Abstract. Let M be a smooth manifold with a regular foliation F and a 2-form ω which induces closed forms on the leaves of F in the leaf topology. A smooth map f : (M, F) −→ (N,σ) in a symplectic manifold (N,σ) is called a foliated symplectic immersion if f restricts to an immersion on each leaf of the foliation and further, the.
Global smoothness preservation and the variation-diminishing property
Directory of Open Access Journals (Sweden)
Gavrea Ioan
1999-01-01
Full Text Available In the center of our paper are two counterexamples showing the independence of the concepts of global smoothness preservation and variation diminution for sequences of approximation operators. Under certain additional assumptions it is shown that the variation-diminishing property is the stronger one. It is also demonstrated, however, that there are positive linear operators giving an optimal pointwise degree of approximation, and which preserve global smoothness, monotonicity and convexity, but are not variation-diminishing.
Susceptibility Genes in Thyroid Autoimmunity
Directory of Open Access Journals (Sweden)
Yoshiyuki Ban
2005-01-01
Full Text Available The autoimmune thyroid diseases (AITD are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. Some of these genes/loci are unique to Graves' disease (GD and Hashimoto's thyroiditis (HT and some are common to both the diseases, indicating that there is a shared genetic susceptibility to GD and HT. The putative GD and HT susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4 and thyroid specific genes (e.g. TSHR, Tg. Most likely, these loci interact and their interactions may influence disease phenotype and severity.
The evolutionary origin of bilaterian smooth and striated myocytes
Brunet, Thibaut; Fischer, Antje HL; Steinmetz, Patrick RH; Lauri, Antonella; Bertucci, Paola; Arendt, Detlev
2016-01-01
The dichotomy between smooth and striated myocytes is fundamental for bilaterian musculature, but its evolutionary origin is unsolved. In particular, interrelationships of visceral smooth muscles remain unclear. Absent in fly and nematode, they have not yet been characterized molecularly outside vertebrates. Here, we characterize expression profile, ultrastructure, contractility and innervation of the musculature in the marine annelid Platynereis dumerilii and identify smooth muscles around the midgut, hindgut and heart that resemble their vertebrate counterparts in molecular fingerprint, contraction speed and nervous control. Our data suggest that both visceral smooth and somatic striated myocytes were present in the protostome-deuterostome ancestor and that smooth myocytes later co-opted the striated contractile module repeatedly – for example, in vertebrate heart evolution. During these smooth-to-striated myocyte conversions, the core regulatory complex of transcription factors conveying myocyte identity remained unchanged, reflecting a general principle in cell type evolution. DOI: http://dx.doi.org/10.7554/eLife.19607.001 PMID:27906129
Understanding Symmetric Smoothing Filters: A Gaussian Mixture Model Perspective
Chan, Stanley H.; Zickler, Todd; Lu, Yue M.
2017-11-01
Many patch-based image denoising algorithms can be formulated as applying a smoothing filter to the noisy image. Expressed as matrices, the smoothing filters must be row normalized so that each row sums to unity. Surprisingly, if we apply a column normalization before the row normalization, the performance of the smoothing filter can often be significantly improved. Prior works showed that such performance gain is related to the Sinkhorn-Knopp balancing algorithm, an iterative procedure that symmetrizes a row-stochastic matrix to a doubly-stochastic matrix. However, a complete understanding of the performance gain phenomenon is still lacking. In this paper, we study the performance gain phenomenon from a statistical learning perspective. We show that Sinkhorn-Knopp is equivalent to an Expectation-Maximization (EM) algorithm of learning a Gaussian mixture model of the image patches. By establishing the correspondence between the steps of Sinkhorn-Knopp and the EM algorithm, we provide a geometrical interpretation of the symmetrization process. This observation allows us to develop a new denoising algorithm called Gaussian mixture model symmetric smoothing filter (GSF). GSF is an extension of the Sinkhorn-Knopp and is a generalization of the original smoothing filters. Despite its simple formulation, GSF outperforms many existing smoothing filters and has a similar performance compared to several state-of-the-art denoising algorithms.
Stimulation of aortic smooth muscle cell mitogenesis by serotonin
Energy Technology Data Exchange (ETDEWEB)
Nemecek, G.M.; Coughlin, S.R.; Handley, D.A.; Moskowitz, M.A.
1986-02-01
Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 ..mu..M serotonin with increased incorporation of (/sup 3/H)thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 ..mu..M. At a concentration of 1 ..mu..M, serotonin stimulated smooth muscle cell mitogenesis to the same extent as human platelet-derived growth factor (PDGF) at 12 ng/ml. Tryptamine was approx. = 1/10th as potent as serotonin as a mitogen for smooth muscle cells. Other indoles that are structurally related to serotonin (D- and L-tryptophan, 5-hydroxy-L-tryptophan, N-acetyl-5-hydroxytryptamine, melatonin, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophol) and quipazine were inactive. The stimulatory effect of serotonin on smooth muscle cell DNA synthesis required prolonged (20-24 hr) exposure to the agonist and was attenuated in the presence of serotonin D receptor antagonists. When smooth muscle cells were incubated with submaximal concentrations of serotonin and PDGF, synergistic rather than additive mitogenic responses were observed. These data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors.
Understanding Symmetric Smoothing Filters: A Gaussian Mixture Model Perspective.
Chan, Stanley H; Zickler, Todd; Lu, Yue M
2017-11-01
Many patch-based image denoising algorithms can be formulated as applying a smoothing filter to the noisy image. Expressed as matrices, the smoothing filters must be row normalized, so that each row sums to unity. Surprisingly, if we apply a column normalization before the row normalization, the performance of the smoothing filter can often be significantly improved. Prior works showed that such performance gain is related to the Sinkhorn-Knopp balancing algorithm, an iterative procedure that symmetrizes a row-stochastic matrix to a doubly stochastic matrix. However, a complete understanding of the performance gain phenomenon is still lacking. In this paper, we study the performance gain phenomenon from a statistical learning perspective. We show that Sinkhorn-Knopp is equivalent to an expectation-maximization (EM) algorithm of learning a Gaussian mixture model of the image patches. By establishing the correspondence between the steps of Sinkhorn-Knopp and the EM algorithm, we provide a geometrical interpretation of the symmetrization process. This observation allows us to develop a new denoising algorithm called Gaussian mixture model symmetric smoothing filter (GSF). GSF is an extension of the Sinkhorn-Knopp and is a generalization of the original smoothing filters. Despite its simple formulation, GSF outperforms many existing smoothing filters and has a similar performance compared with several state-of-the-art denoising algorithms.
Stein, David B.; Guy, Robert D; Thomases, Becca
2015-01-01
The Immersed Boundary method is a simple, efficient, and robust numerical scheme for solving PDE in general domains, yet it only achieves first-order spatial accuracy near embedded boundaries. In this paper, we introduce a new high-order numerical method which we call the Immersed Boundary Smooth Extension (IBSE) method. The IBSE method achieves high-order accuracy by smoothly extending the unknown solution of the PDE from a given sm...
Inherited susceptibility and radiation exposure
Energy Technology Data Exchange (ETDEWEB)
Little, J.B. [Harvard School of Public Health, Boston, MA (United States)
1997-03-01
There is continuing concern that some people in the general population may have genetic makeups that place them at particularly high risk for radiation-induced cancer. The existence of such a susceptible subpopulation would have obvious implications for the estimation of risks of radiation exposure. Although it has been long known that familial aggregations of cancer do sometimes occur, recent evidence suggests that a general genetic predisposition to cancer does not exist; most cancers occur sporadically. On the other hand, nearly 10% of the known Mendelian genetic disorders are associated with cancer. A number of these involve a familial predisposition to cancer, and some are characterized by an enhanced susceptibility to the induction of cancer by various physical and chemical carcinogens, including ionizing radiation. Such increased susceptibility will depend on several factors including the frequency of the susceptibility gene in the population and its penetrance, the strength of the predisposition, and the degree to which the cancer incidence in susceptible individuals may be increased by the carcinogen. It is now known that these cancer-predisposing genes may be responsible not only for rare familial cancer syndromes, but also for a proportion of the common cancers. Although the currently known disorders can account for only a small fraction of all cancers, they serve as models for genetic predisposition to carcinogen-induced cancer in the general population. In the present report, the author describes current knowledge of those specific disorders that are associated with an enhanced predisposition to radiation-induced cancer, and discusses how this knowledge may bear on the susceptibility to radiation-induced cancer in the general population and estimates of the risk of radiation exposure.
pitting corrosion susceptibility pitting corrosion susceptibility of aisi ...
African Journals Online (AJOL)
eobe
Abstract. The susceptibility of austenitic (AISI 301) stainless steel to pitting corrosion was evaluated in sodium chloride. (NaCl) solutions ... AISI 301 steel suffers from pitting corrosion in all the investigated solutions. AISI 301 steel suffers from ..... [1] Ijeomah, M.N.C. Elements of Corrosion and Protection. Theory, Auto Century ...
Magnetic Susceptability Measurements in Superconductors
Kim, Jason; Mallory, Kendall; Seim, Ryan
2000-04-01
A new undergraduate research facility in magnetic susceptability measurements on superconductors is being developed at the University of Northern Colorado. Initial data measurements of the magnetic susceptability of various superconductors will be presented. These measurements were obtained with a liquid helium/nitrogen dewar that was reassembled for use in this project. The cryostat consists of two separate dewars, the first of which contains liquid nitrogen, the second, liquid helium. The liquid nitrogen dewar is used to keep the helium bath from evaporating off too quickly. Data on the evaporation rates of the two liquids will also be presented.
Directory of Open Access Journals (Sweden)
Liu Yan-hong
2011-09-01
Full Text Available Abstract Background Genes in the major histocompatibility complex (MHC have a critical role in both the innate and adaptive immune responses because of their involvement in presenting foreign peptides to T cells. However, the nature has remained largely unknown. Results We examined the genetic variation in MHC class IIB in half-smooth tongue sole (Cynoglossus semilaevis after challenge with vibrio anguillarum. Two thousand and four hundred fry from 12 half-smooth tongue sole families were challenged with Vibrio anguillarum. To determine any association between alleles and resistance or susceptibility to V. anguillarum, 160 individuals from four high-resistance (HR, 73.27% mortality families were selected for MHC IIB exon2 gene sequence analysis. The MHC IIB exon2 genes of tongue sole displayed a high level of polymorphism and were discovered at least four loci. Meanwhile, the dN/dS [the ratio of non-synonymous (dN substitutions to synonymous (dS substitutions] in the peptide-binding region (PBR was higher than that in the non-peptide-binding region (non-PBR. Eighty-eight alleles were discovered among 160 individuals, and 13 out of 88 alleles were used to analyze the distribution pattern between the resistant and susceptible families. Certain alleles presented in HR and LR with a different frequency, while other alleles were discovered in only the HR or LR families, not both. Five alleles, Cyse-DBB*6501, Cyse-DBB*4002, Cyse-DBB*6102, Cyse-DBB*5601 and Cyse-DBB*2801, were found to be associated with susceptibility to V. anguillarum with a frequency of 1.25%, 1.25%, 1.25%, 1.25% and 2.5% in the HR families, and 35%, 33.75%, 27.5%, 16.25%, 15% in the LR families (p Cyse-DBB*3301, Cyse-DBB*4701, Cyse-DBB*6801 and Cyse-DBB*5901, were found to be associated with resistance to V. anguillarum, with a frequency of 13.75%, 11.25%, 11.25%, 8.75% in the HR families and 1.25%, 1.25%, 1.25%, 1.25% and 1.25% in the LR families (p Conclusions Elucidation of the
Huang, Kuo-Chin; Li, Te-Mao; Liu, Xiang; Chen, Jin-Hua; Chien, Wen-Kuei; Shiao, Yi-Tzone; Tsang, Hsinyi; Lin, Ting-Hsu; Liao, Chiu-Chu; Huang, Shao-Mei; Li, Ju-Pi; Lin, Cheng-Wen; Lin, Jung-Chun; Lin, Chih-Chien; Lai, Chih-Ho; Cheng, Chi-Fung; Liang, Wen-Miin; Hung, Chien-Hui; Chen, Ching-Chu; Lin, Ying-Ju; Tsai, Fuu-Jen
2017-12-01
KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients with T2DM, we divided the T2DM cohort into hypertension (n = 452) and non-hypertension (n = 541) groups. The Mann-Whitney U test, chi-square test, and multivariate regression analyses were used to assess the clinical characteristics and genotypic frequencies. In vitro studies utilized the rat aortic smooth muscle A10 cell line. Patients in the hypertension group were significantly older at the time of enrollment and had higher levels of body mass index, waist-to-hip ratio, and triglyceride than those in the non-hypertension group. The KCNQ1 rs3864884 and rs12576239 genetic variants were associated with hypertension in T2DM. KCNQ1 expression was lower in the individuals with the CC versus the CT and TT genotypes. Smooth muscle cell contractility was inhibited by treatment with a KCNQ1 inhibitor. These results suggest that KCNQ1 might be associated with hypertension in individuals with T2DM. © 2017 Wiley Periodicals, Inc.
Topological susceptibility from the overlap
DEFF Research Database (Denmark)
Del Debbio, Luigi; Pica, Claudio
2003-01-01
The chiral symmetry at finite lattice spacing of Ginsparg-Wilson fermionic actions constrains the renormalization of the lattice operators; in particular, the topological susceptibility does not require any renormalization, when using a fermionic estimator to define the topological charge. Theref...
Intermittent Smoothing Approaches for Wind Power Output: A Review
Directory of Open Access Journals (Sweden)
Muhammad Jabir
2017-10-01
Full Text Available Wind energy is one of the most common types of renewable energy resource. Due to its sustainability and environmental benefits, it is an emerging source for electric power generation. Rapid and random changes of wind speed makes it an irregular and inconsistent power source when connected to the grid, causing different technical problems in protection, power quality and generation dispatch control. Due to these problems, effective intermittent smoothing approaches for wind power output are crucially needed to minimize such problems. This paper reviews various intermittent smoothing approaches used in smoothing the output power fluctuations caused by wind energy. Problems associated with the inclusion of wind energy resources to grid are also briefly reviewed. From this review, it has been found that battery energy storage system is the most suitable and effective smoothing approach, provided that an effective control strategy is available for optimal utilization of battery energy system. This paper further demonstrates different control strategies built for battery energy storage system to obtain the smooth output wind power.
Geographic smoothing of solar PV: results from Gujarat
Klima, Kelly; Apt, Jay
2015-10-01
We examine the potential for geographic smoothing of solar photovoltaic (PV) electricity generation using 13 months of observed power production from utility-scale plants in Gujarat, India. To our knowledge, this is the first published analysis of geographic smoothing of solar PV using actual generation data at high time resolution from utility-scale solar PV plants. We use geographic correlation and Fourier transform estimates of the power spectral density (PSD) to characterize the observed variability of operating solar PV plants as a function of time scale. Most plants show a spectrum that is linear in the log-log domain at high frequencies f, ranging from {f}-1.23 to {f}-1.56 (slopes of -1.23 and -1.56), thus exhibiting more relative variability at high frequencies than exhibited by wind plants. PSDs for large PV plants have a steeper slope than those for small plants, hence more smoothing at short time scales. Interconnecting 20 Gujarat plants yields a {f}-1.66 spectrum, reducing fluctuations at frequencies corresponding to 6 h and 1 h by 23% and 45%, respectively. Half of this smoothing can be obtained through connecting 4-5 plants; reaching marginal improvement of 1% per added plant occurs at 12-14 plants. The largest plant (322 MW) showed an {f}-1.76 spectrum. This suggests that in Gujarat the potential for smoothing is limited to that obtained by one large plant.
Accuracy of eye position for saccades and smooth pursuit.
Shanidze, Natela; Ghahghaei, Saeideh; Verghese, Preeti
2016-12-01
In this study, we address the question of whether a target is foveated during smooth pursuit. Specifically, we examine whether smooth pursuit eye movements land near the center-of-mass of the target, as is the case for saccades. To that end, we instructed eight untrained, healthy participants to follow moving targets, presented monocularly in a scanning laser ophthalmoscope. Stimuli moved either in a modified step-ramp (smooth pursuit), or made a single step (saccade), stepping 6° from the center. Targets were ring-shaped and either 0.6° or 1.7° in diameter. In an additional set of experiments, two participants collected more extensive data on smooth pursuit and saccades for a larger range of target sizes (0.6°, 1.7°, or 4.3°). During pursuit, eyes were rarely placed at target center, even when participants' fixational stability was taken into account. Furthermore, there was a clear tendency for distance from target center to increase with target size. This outcome was in contrast to saccades, where there was no effect of target size across participants. The difference in foveal placement between the two types of eye movements is consistent with their different purposes: closer inspection of the target for saccades versus maintenance of the target in the visual field for smooth pursuit.
Capey, Steven; van den Berg, Carmen W
2005-05-01
Accelerated atherosclerosis after transplantation has been observed and is characterized by smooth muscle cell proliferation in the graft. Porcine cells are frequently used in models of atherosclerosis and porcine organs are considered for use in transplantation. Complement (C) activation is known to play a major role in rejection of xenografts and is also considered to play a role in the development of atherosclerosis. The aim of this study was to investigate the expression and function of membrane bound regulators of complement (CReg) on porcine aortic smooth muscle cells (PASMC). The PASMC were assessed for expression of CReg and susceptibility to lysis by human C by flow-cytometry. The effect of various cytokines on CReg expression and C-susceptibility was investigated. The ability of human C to induce cell proliferation was assessed using the Alamar blue assay. The PASMC only express the CReg membrane cofactor protein (MCP) and CD59 on their cell surface. MCP expression was increased by interleukin (IL)-4. In contrast to porcine aortic endothelial cells (PAEC), PASMC were found to be surprisingly sensitive to C-mediated lysis, mainly due to a low level of expression of CD59. Human C-induced proliferation of PASMC, which was dependent on complete membrane attack complex (MAC) formation. Endogenously expressed CReg on PASMC poorly protect these cells to human C. Human C can induce proliferation of PASMC. In order to prevent accelerated atherosclerosis in porcine xenografts, increased levels of CReg not only have to be obtained on the endothelial cells but also on the smooth muscle cells.
Smoothing-Norm Preconditioning for Regularizing Minimum-Residual Methods
DEFF Research Database (Denmark)
Hansen, Per Christian; Jensen, Toke Koldborg
2006-01-01
When GMRES (or a similar minimum-residual algorithm such as RRGMRES, MINRES, or MR-II) is applied to a discrete ill-posed problem with a square matrix, in some cases the iterates can be considered as regularized solutions. We show how to precondition these methods in such a way that the iterations...... take into account a smoothing norm for the solution. This technique is well established for CGLS, but it does not immediately carry over to minimum-residual methods when the smoothing norm is a seminorm or a Sobolev norm. We develop a new technique which works for any smoothing norm of the form $\\|L......\\,x\\|_2$ and which preserves symmetry if the coefficient matrix is symmetric. We also discuss the efficient implementation of our preconditioning technique, and we demonstrate its performance with numerical examples in one and two dimensions....
Return Smoothing Mechanisms in Life and Pension Insurance
DEFF Research Database (Denmark)
Montserrat, Guillén; Jørgensen, Peter Løchte; Nielsen, Jens Perch
2006-01-01
Traditional with-profits pension saving schemes have been criticized for their opacity, plagued by embedded options and guarantees, and have recently created enormous problems for the solvency of the life insurance and pension industry. This has fueled creativity in the industry's product...... development departments, and this paper analyzes a representative member of a family of new pension schemes that have been introduced in the new millennium to alleviate these problems. The complete transparency of the new scheme's smoothing mechanism means that it can be analyzed using contingent claims...... pricing theory. We explore the properties of this pension scheme in detail and find that in terms of market value, smoothing is an illusion, but also that the return smoothing mechanism implies a dynamic asset allocation strategy which corresponds with traditional pension saving advice...
Smoothing the payoff for efficient computation of Basket option prices
Bayer, Christian
2017-07-22
We consider the problem of pricing basket options in a multivariate Black–Scholes or Variance-Gamma model. From a numerical point of view, pricing such options corresponds to moderate and high-dimensional numerical integration problems with non-smooth integrands. Due to this lack of regularity, higher order numerical integration techniques may not be directly available, requiring the use of methods like Monte Carlo specifically designed to work for non-regular problems. We propose to use the inherent smoothing property of the density of the underlying in the above models to mollify the payoff function by means of an exact conditional expectation. The resulting conditional expectation is unbiased and yields a smooth integrand, which is amenable to the efficient use of adaptive sparse-grid cubature. Numerical examples indicate that the high-order method may perform orders of magnitude faster than Monte Carlo or Quasi Monte Carlo methods in dimensions up to 35.
Czuryło, Edward A; Kulikova, Natalia; Sobota, Andrzej
2008-05-01
Lysenin, a toxin present in the coelomic fluid of the earthworm Eisenia foetida, is known to cause a long-lasting contraction of rat aorta smooth muscle strips. We addressed the mechanisms underlying its action on smooth muscle cells and present the first report demonstrating a completely new property of lysenin unrelated to its basic sphingomyelin-binding ability. Here we report lysenin enhancement effect on smooth muscle actomyosin ATPase activity and the ability of networking the actin filaments. The maximum enhancement of the ATPase activity of actomyosin at 120 mM KCl was observed at a molar ratio of lysenin to actin of about 1:10(5), while at 70 mM KCl at the ratio of about 1:10(6). The effect of lysenin became most pronounced only when both smooth muscle regulatory proteins, tropomyosin and caldesmon, were present. Co-sedimentation experiments indicated that lysenin did not displace neither tropomyosin nor caldesmon from the thin filament. Thus, the lysenin-dependent abolishment of the inhibitory effect of caldesmon on the ATPase activity was related rather to the modification of the filament structure. The ability of the toxin to exert its stimulatory effect at extremely low concentrations (as low as one molecule of lysenin per 10(6) actin molecules) may result from the long-range cooperative transitions in the entire thin filament with an involvement of smooth muscle tropomyosin, while the role of caldesmon may be limited exclusively to the inhibition of ATPase activity.
Chlamydia pneumoniae induces aponecrosis in human aortic smooth muscle cells
Directory of Open Access Journals (Sweden)
Walch Michael
2005-01-01
Full Text Available Abstract Background The intracellular bacterium Chlamydia pneumoniae is suspected to play a role in formation and progression of atherosclerosis. Many studies investigated cell death initiation versus inhibition by Chlamydia pneumoniae in established cell lines but nothing is known in primary human aortic smooth muscle cells, a cell type among others known to be involved in the formation of the atherosclerotic plaque. Type of cell death was analyzed by various methods in primary aortic smooth muscle cells after infection with Chlamydia pneumoniae to investigate a possible pathogenic link in atherosclerosis. Results Chlamydiae were found to be localized up to 72 h post infection in aortic smooth muscle cells either as single bacteria or inside of large inclusions. Quantification of host cell death by lactate dehydrogenase release assay revealed strictly dose and time dependent lysis for all tested isolates of Chlamydia pneumoniae. Phosphatidylserine exposure was detected by flow cytometry in Chlamydia pneumoniae infected cells. Ultrastructure of Chlamydia pneumoniae infected human aortic smooth muscle cells showed extensive membrane- and organelle damage, chromatin condensation but no nuclear fragmentation. DNA fragmentation as well as cell membrane permeability was analyzed by TUNEL and NHS-biotin staining and occurred exclusively in cells carrying Chlamydia pneumoniae spots but not in smooth muscle cells with inclusions. These morphological features of cell death were not accompanied by an activation of caspase-3 as revealed by analysis of enzyme activity but involved mitochondrial membrane depolarization as shown by TMRE uptake and release of cytochrome c from mitochondria. Conclusion This study provides evidence that Chlamydia pneumoniae induce a spot like infection in human aortic smooth muscle cells, which results in a chimeric cell death with both apoptotic and necrotic characteristics. This aponecrotic cell death may assist chronic
The Initiation of Smooth Pursuit is Delayed in Anisometropic Amblyopia.
Raashid, Rana Arham; Liu, Ivy Ziqian; Blakeman, Alan; Goltz, Herbert C; Wong, Agnes M F
2016-04-01
Several behavioral studies have shown that the reaction times of visually guided movements are slower in people with amblyopia, particularly during amblyopic eye viewing. Here, we tested the hypothesis that the initiation of smooth pursuit eye movements, which are responsible for accurately keeping moving objects on the fovea, is delayed in people with anisometropic amblyopia. Eleven participants with anisometropic amblyopia and 14 visually normal observers were asked to track a step-ramp target moving at ±15°/s horizontally as quickly and as accurately as possible. The experiment was conducted under three viewing conditions: amblyopic/nondominant eye, binocular, and fellow/dominant eye viewing. Outcome measures were smooth pursuit latency, open-loop gain, steady state gain, and catch-up saccade frequency. Participants with anisometropic amblyopia initiated smooth pursuit significantly slower during amblyopic eye viewing (206 ± 20 ms) than visually normal observers viewing with their nondominant eye (183 ± 17 ms, P = 0.002). However, mean pursuit latency in the anisometropic amblyopia group during binocular and monocular fellow eye viewing was comparable to the visually normal group. Mean open-loop gain, steady state gain, and catch-up saccade frequency were similar between the two groups, but participants with anisometropic amblyopia exhibited more variable steady state gain (P = 0.045). This study provides evidence of temporally delayed smooth pursuit initiation in anisometropic amblyopia. After initiation, the smooth pursuit velocity profile in anisometropic amblyopia participants is similar to visually normal controls. This finding differs from what has been observed previously in participants with strabismic amblyopia who exhibit reduced smooth pursuit velocity gains with more catch-up saccades.
Histomorphometry of penile smooth muscle fiber in severe erectile dysfunction
Directory of Open Access Journals (Sweden)
Joaquim de Almeida Claro
Full Text Available CONTEXT AND OBJECTIVE: Smooth muscle fiber has fundamental importance in erection. Alterations in its function or quantity may be associated with erectile dysfunction. The study objective was to assess the proportion of penile smooth muscle fiber in patients with severe erectile dysfunction. DESIGN AND SETTING: Clinical study, in the Sexual Dysfunction Group, Universidade Federal de São Paulo (Unifesp, and in the Anatomy Laboratory, Universidade Estadual do Rio de Janeiro (UERJ. METHODS: Twenty patients with severe erectile dysfunction were selected to form two groups of ten patients: one with normal arterial flow (age range: 44 to 78 years and the other with altered arterial flow (age range: 38 to 67 years. These groups were compared with a group formed by ten cadavers aged 18 to 25 years that were presumed to have been potent. Quantification of the smooth muscle fibers was done by means of an immunohistochemical study. RESULTS: The proportion of smooth muscle fiber found was 41.15% for the control group. The patients with erectile dysfunction and normal arterial flow presented 27.24% and those with altered arterial flow presented 25.74%; 19 patients presented at least one chronic disease or risk factor for erectile dysfunction, with prominence for diabetes mellitus, systemic arterial hypertension and smoking. CONCLUSION: Among patients with severe erectile dysfunction, the arterial flow on its own does not present interference in the proportion of smooth muscle fiber. The diminution of the proportion of smooth muscle fiber may result from chronic diseases and vascular risk factors.
Motion dependence of smooth pursuit eye movements in the marmoset.
Mitchell, Jude F; Priebe, Nicholas J; Miller, Cory T
2015-06-01
Smooth pursuit eye movements stabilize slow-moving objects on the retina by matching eye velocity with target velocity. Two critical components are required to generate smooth pursuit: first, because it is a voluntary eye movement, the subject must select a target to pursue to engage the tracking system; and second, generating smooth pursuit requires a moving stimulus. We examined whether this behavior also exists in the common marmoset, a New World primate that is increasingly attracting attention as a genetic model for mental disease and systems neuroscience. We measured smooth pursuit in two marmosets, previously trained to perform fixation tasks, using the standard Rashbass step-ramp pursuit paradigm. We first measured the aspects of visual motion that drive pursuit eye movements. Smooth eye movements were in the same direction as target motion, indicating that pursuit was driven by target movement rather than by displacement. Both the open-loop acceleration and closed-loop eye velocity exhibited a linear relationship with target velocity for slow-moving targets, but this relationship declined for higher speeds. We next examined whether marmoset pursuit eye movements depend on an active engagement of the pursuit system by measuring smooth eye movements evoked by small perturbations of motion from fixation or during pursuit. Pursuit eye movements were much larger during pursuit than from fixation, indicating that pursuit is actively gated. Several practical advantages of the marmoset brain, including the accessibility of the middle temporal (MT) area and frontal eye fields at the cortical surface, merit its utilization for studying pursuit movements. Copyright © 2015 the American Physiological Society.
Adaptive control of energy storage systems for power smoothing applications
DEFF Research Database (Denmark)
Meng, Lexuan; Dragicevic, Tomislav; Guerrero, Josep M.
2017-01-01
for systems with multiple ESS units to realize several objectives simultaneously including SoC limiting, SoC balancing and power smoothing. Experiment is conducted considering a pulsed load profile. The results demonstrate the effectiveness of the proposal concerning the mentioned control objectives.......Energy storage systems (ESSs) are desired and widely applied for power smoothing especially in systems with renewable generation and pulsed loads. High-pass-filter (HPF) is commonly applied in those applications in which the HPF extracts the high frequency fluctuating power and uses...
Modelling conditional correlations of asset returns: A smooth transition approach
DEFF Research Database (Denmark)
Silvennoinen, Annastiina; Teräsvirta, Timo
In this paper we propose a new multivariate GARCH model with time-varying conditional correlation structure. The time-varying conditional correlations change smoothly between two extreme states of constant correlations according to a predetermined or exogenous transition variable. An LM-test is d......In this paper we propose a new multivariate GARCH model with time-varying conditional correlation structure. The time-varying conditional correlations change smoothly between two extreme states of constant correlations according to a predetermined or exogenous transition variable. An LM...
Porcine Stomach Smooth Muscle Force Depends on History-Effects
Directory of Open Access Journals (Sweden)
André Tomalka
2017-10-01
Full Text Available The stomach serves as food reservoir, mixing organ and absorption area for certain substances, while continually varying its position and size. Large dimensional changes during ingestion and gastric emptying of the stomach are associated with large changes in smooth muscle length. These length changes might induce history-effects, namely force depression (FD following active muscle shortening and force enhancement (FE following active muscle stretch. Both effects have impact on the force generating capacity of the stomach, and thus functional relevance. However, less is known about history-effects and active smooth muscle properties of stomach smooth muscle. Thus, the aim of this study was to investigate biomechanical muscle properties as force-length and force-velocity relations (FVR of porcine stomach smooth muscle strips, extended by the analysis of history-effects on smooth muscle force. Therefore, in total n = 54 tissue strips were dissected in longitudinal direction from the ventral fundus of porcine stomachs. Different isometric, isotonic, and isokinetic contraction protocols were performed during electrical muscle stimulation. Cross-sectional areas (CSA of smooth muscles were determined from cryo-histological sections stained with Picrosirius Red. Results revealed that maximum smooth muscle tension was 10.4 ± 2.6 N/cm2. Maximum shortening velocity (Vmax and curvature factor (curv of the FVR were 0.04 ± 0.01 [optimum muscle length/s] and 0.36 ± 0.15, respectively. The findings of the present study demonstrated significant (P < 0.05 FD [up to 32% maximum muscle force (Fim] and FE (up to 16% Fim of gastric muscle tissue, respectively. The FE- and FD-values increased with increasing ramp amplitude. This outstanding muscle behavior is not accounted for in existing models so far and strongly supports the idea of a holistic reflection of distinct stomach structure and function. For the first time this study provides a comprehensive set of
Airway smooth muscle excitation-contraction coupling and airway hyperresponsiveness.
Hirota, Simon; Helli, Peter B; Catalli, Adriana; Chew, Allyson; Janssen, Luke J
2005-01-01
The primary complaints from patients with asthma pertain to function of airway smooth muscle (ASM) function including shortness of breath, wheezing, and coughing. Thus, it is imperative to better understand the mechanisms underlying excitation-contraction coupling in ASM. Here, we review the various signaling pathways underlying contraction in ASM, and then examine how these are altered in asthma and airway hyperresponsiveness (a hallmark feature of asthma). Throughout, we highlight how studies of vascular smooth muscle have helped or hindered progress in understanding ASM physiology and pathophysiology.
Methods and electrolytes for electrodeposition of smooth films
Zhang, Jiguang; Xu, Wu; Graff, Gordon L; Chen, Xilin; Ding, Fei; Shao, Yuyan
2015-03-17
Electrodeposition involving an electrolyte having a surface-smoothing additive can result in self-healing, instead of self-amplification, of initial protuberant tips that give rise to roughness and/or dendrite formation on the substrate and/or film surface. For electrodeposition of a first conductive material (C1) on a substrate from one or more reactants in an electrolyte solution, the electrolyte solution is characterized by a surface-smoothing additive containing cations of a second conductive material (C2), wherein cations of C2 have an effective electrochemical reduction potential in the solution lower than that of the reactants.
The smooth entropy formalism for von Neumann algebras
Energy Technology Data Exchange (ETDEWEB)
Berta, Mario, E-mail: berta@caltech.edu [Institute for Quantum Information and Matter, California Institute of Technology, Pasadena, California 91125 (United States); Furrer, Fabian, E-mail: furrer@eve.phys.s.u-tokyo.ac.jp [Department of Physics, Graduate School of Science, University of Tokyo, Tokyo, Japan and Institute for Theoretical Physics, Leibniz University Hanover, Hanover (Germany); Scholz, Volkher B., E-mail: scholz@phys.ethz.ch [Institute for Theoretical Physics, ETH Zurich, Zurich (Switzerland)
2016-01-15
We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.
Inhibitory action of relaxin on human cervical smooth muscle.
Norström, A; Bryman, I; Wiqvist, N; Sahni, S; Lindblom, B
1984-09-01
The influence of purified porcine relaxin on contractility of human cervical smooth muscle was investigated in vitro. Strips of cervical tissue were obtained by needle biopsy from pregnant and nonpregnant women and were mounted in a superfused organ chamber for isometric measurement of contractile activity. Relaxin (0.005-25 micrograms/ml) inhibited the spontaneous contractions in cervical strips from 18% of nonpregnant, 68% of early pregnant, and in 100% of term pregnant women. These results indicate that relaxin has an inhibitory action on cervical smooth muscle and that this effect is more constantly detected as pregnancy proceeds.
Smooth torque speed characteristic of switched reluctance motors
DEFF Research Database (Denmark)
Zeng, Hui; Chen, Zhe; Chen, Hao
2014-01-01
The torque ripple of switched reluctance motors (SRMs) is the main disadvantage that limits the industrial application of these motors. Although several methods for smooth-toque operation (STO) have been proposed, STO works well only within a certain torque and speed range because of the constrai......The torque ripple of switched reluctance motors (SRMs) is the main disadvantage that limits the industrial application of these motors. Although several methods for smooth-toque operation (STO) have been proposed, STO works well only within a certain torque and speed range because...
The comparative susceptibility of commercial and Nigerian ...
African Journals Online (AJOL)
This study was to evaluate the possible genetic resistance of exotic and indigenous chicks to Salmonella gallinarum. A total of 72 nine weeks-old chicks were used for the study. The Fulani ecotype (Fulani smooth feathers - FSF), Yoruba ecotype (Yoruba smooth feathers - YSF), and the Exotic breed (Nera Black) chicks were ...
Reducing Susceptibility to Courtesy Stigma.
Bachleda, Catherine L; El Menzhi, Leila
2017-04-19
In light of the chronic shortage of health professionals willing to care for HIV/AIDS patients, and rising epidemics in many Muslim countries, this qualitative study examined susceptibility and resistance to courtesy stigma as experienced by nurses, doctors, and social workers in Morocco. Forty-nine in-depth interviews provided rich insights into the process of courtesy stigma and how it is managed, within the context of interactions with Islam, interactions within the workplace (patients, other health professionals), and interactions outside the workplace (the general public, friends, and family). Theoretically, the findings extend understanding of courtesy stigma and the dirty work literature. The findings also offer practical suggestions for the development of culturally appropriate strategies to reduce susceptibility to courtesy stigmatization. This study represents the first to explore courtesy stigma as a process experienced by health professionals providing HIV/AIDS care in an Islamic country.
Kordilla, J.; Tartakovsky, A. M.; Geyer, T.
2014-12-01
Unsaturated flow in fractured porous media exhibits highly complex flow dynamics and a wide range of intermittent flow processes. Especially in wide aperture fractures, flow processes may be dominated by gravitational instead of capillary forces leading to a deviation from the classical volume effective approaches (Richard's equation, Van Genuchten type relationships). The existence of various flow modes such as droplets, rivulets, turbulent and adsorbed films is well known, however, their spatial and temporal distribution within fracture networks is still an open question partially due to the lack of appropriate modeling tools. With our work we want to gain a deeper understanding of the underlying flow and transport dynamics in unsaturated fractured media in order to support the development of more refined upscaled methods, applicable on catchment scales. We present pore- and fracture-scale flow simulations obtained with a Smoothed Particle Hydrodynamics (SPH) model. The model allows to simulate free-surface flow dynamics including the effect of surface tension for a wide range of wetting conditions. Several empirical and semi-analytical solutions are used to verify the model. We show that our results satisfy the empirical scaling laws for droplet velocity and critical contact angle. Due to the efficient generation of surface tension via particle-particle interaction forces the dynamic wetting of surfaces as well as the velocity enhancement of droplets on saturated surfaces can readily be obtained. Furthermore, we study the effect of surface roughness on droplet velocities. Lastly, we present flow and transport simulations in the presence of an adjacent porous matrix in order to investigate its influence on the fracture surface flow dynamics and transport across the matrix-fracture interface.
Antimycotics susceptibility testing of dermatophytes
Directory of Open Access Journals (Sweden)
Arsić-Arsenijević Valentina
2010-01-01
Full Text Available Dermatophytes are moulds that produce infections of the skin, hair and nails of humans and animals. The most common forms among these infections are onychomycosis and tinea pedis affecting 20% of world population. These infections are usually chronic. The treatment of dermatophytoses tends to be prolonged partly because available treatments are not very effective. Antifungal drug consumption and public health expenditure are high worldwide, as well as in Serbia. For adequate therapy, it is necessary to prove infection by isolation of dermatophytes and to test the antifungal susceptibility of isolates. Susceptibility testing is important for the resistance monitoring, epidemiological research and to compare in vitro activities of new antifungal agents. The diffusion and dilution methods of susceptibility tests are used, and technical issues of importance for the proper performance and interpretation of test results are published in the document E.DEF 9.1 (EUCAST and M38-A2 (CLSI. The aim of our paper is to promptly inform the public about technical achievements in this area, as well as the new organization of laboratory for medical mycology in our country. The formation of laboratory networks coordinated by the National Reference Laboratory for the cause of mycosis need to enable interlaboratory studies and further standardization of methods for antifungal susceptibility testing of dermatophytes, reproducibility of tests and clinical correlation monitoring (MIK values and clinical outcome of dermatophytosis. The importance of the new organization is expected efficient improvement in the dermatophytosis therapy at home, better quality of patient's life and the reduction of the cost of treatment.
Antibiotic susceptibility of Atopobium vaginae
Directory of Open Access Journals (Sweden)
Verschraegen Gerda
2006-03-01
Full Text Available Abstract Background Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV. Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV. Methods Nine strains of Atopobium vaginae, four strains of Gardnerella vaginalis, two strains of Lactobacillus iners and one strain each of Bifidobacterium breve, B. longum, L. crispatus, L. gasseri and L. jensenii were tested against 15 antimicrobial agents using the Etest. Results All nine strains of A. vaginae were highly resistant to nalidixic acid and colistin while being inhibited by low concentrations of clindamycin (range: G. vaginalis strains were also susceptible for clindamycin ( 256 μg/ml but susceptible to clindamycin (0.023 – 0.125 μg/ml. Conclusion Clindamycin has higher activity against G. vaginalis and A. vaginae than metronidazole, but not all A. vaginae isolates are metronidazole resistant, as seemed to be a straightforward conclusion from previous studies on a more limited number of strains.
Measurements of temperature dependence of 'localized susceptibility'
Shiozawa, H; Ishii, H; Takayama, Y; Obu, K; Muro, T; Saitoh, Y; Matsuda, T D; Sugawara, H; Sato, H
2003-01-01
The magnetic susceptibility of some rare-earth compounds is estimated by measuring magnetic circular dichroism (MCD) of rare-earth 3d-4f absorption spectra. The temperature dependence of the magnetic susceptibility obtained by the MCD measurement is remarkably different from the bulk susceptibility in most samples, which is attributed to the strong site selectivity of the core MCD measurement.
Incremental susceptibility of individual tooth surfaces to dental caries in Scottish adolescents.
Chestnutt, I G; Schafer, F; Jacobson, A P; Stephen, K W
1996-02-01
This study reports on the caries susceptibility of tooth surfaces in 4294 adolescents (mean age 12.5 yr) during a 3-yr, double-blind clinical caries trial, conducted in Lanarkshire, Scotland, between 1988 and 1992. Children were selected on the grounds of dental maturity and past caries experience. Clinical examinations with mirror, CPITN probe and fibre optic trans-illumination were carried out on the permanent dentition, with the buccal pits of mandibular molars and palatal pits of maxillary molars being recorded as separate sites. At baseline 6061 surfaces were decayed (1.0% of 601 160 surfaces examined), 20 160 (3.4%) filled, and 10 909 (1.8%) missing due to caries. The number of surfaces recorded as sound at baseline in subjects completing the study was 454 663. Of these 8176 (1.8%) new surfaces were decayed, 14 832 (3.3%) filled and 4000 (0.9%) missing at the final examination. Molar occlusal surfaces showed greatest susceptibility to attack, 35.8%) of those at risk becoming carious in the course of the study. All buccal and lingual smooth surfaces showed a low susceptibility, but 8.8% of buccal and palatal pits developed caries. At the final clinical-only examination, pit and fissure caries accounted for 48%, interproximal surfaces for 39%, and smooth surfaces for 13% of caries prevalence. However, overall the contribution of these surfaces to 3-yr increments was, 40%, 47% and 13%, respectively.
Operational calculus and differential equations with infinitely smooth coefficients
Directory of Open Access Journals (Sweden)
Dennis Nemzer
1990-01-01
Full Text Available A subring MF of the field of Mikusiński operators is constructed as a countable union space. Some topological properties of MF are investigated. Then, the product of an infinitely differentiable function and an element of MF is given and is used to investigate operational equations with infinitely smooth coefficients.
Suppression of vascular smooth muscle cells' proliferation and ...
African Journals Online (AJOL)
This study aimed to determine the effects of valsartan on the proliferation and migration of isolated rat vascular smooth muscle cells (VSMCs) and the expression of phospho-p42/44 mitogen-activated protein kinase (MAPK) promoted by angiotensin II (Ang II). VSMCs from the rat thoracic aorta were cultured by ...
[Intrarenal smooth muscle: histology of a complex urodymamic machine].
Arias, L F; Ortiz-Arango, N
2013-03-01
To know better the microscopic arrangement of the bundles of smooth muscle in the human renal parenchyma, their distribution and anatomical relationships, trying to make a reconstruction of this muscular system. Five adult human kidneys and one fetal kidney were processed "in toto" with cross sections every 300μm. In the histological sections we identify the smooth muscle fibers trying to determine its insertion, course and anatomical relationship with other structures of the kidney tissue. There are bundles of smooth muscle fibers of variable thickness parallel to the edges of the medullary pyramids, bundles that surrounding the medulla in a spiral course, and bundles that accompany arcuate vessels, the latter being the most abundant and easy to identify. These groups of muscle fibers do not have a precise or constant insertion site, their periodicity is not homogeneous and they are not a direct extension of the muscle of the renal pelvis, although some bundles are in contact with it. There are also unusual and inconstant small muscle fibers no associated to vessels in the interstitium of the cortex and, exceptionally, in the medulla. There is a complex microscopic system of smooth muscle fibers that partially surround the renal medulla and are related to renal pelvic muscles without a direct continuity with them. Although this small muscular system is under-recognized, could be very important in urodynamics. Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved.
Wide-band array signal processing via spectral smoothing
Xu, Guanghan; Kailath, Thomas
1989-01-01
A novel algorithm for the estimation of direction-of-arrivals (DOA) of multiple wide-band sources via spectral smoothing is presented. The proposed algorithm does not require an initial DOA estimate or a specific signal model. The advantages of replacing the MUSIC search with an ESPRIT search are discussed.
Smooth Rényi Entropy of Ergodic Quantum Information Sources
Schoenmakers, Berry; Tjoelker, Jilles; Tuyls, Pim; Verbitskiy, Evgeny
2007-01-01
We investigate the recently introduced notion of smooth Rényi entropy for the case of ergodic information sources, thereby generalizing previous work which concentrated mainly on i.i.d. information sources. We will actually consider ergodic quantum information sources, of which ergodic classical
Smoothing depth maps for improved steroscopic image quality
Tam, Wa James; Alain, Guillaume; Zhang, Liang; Martin, Taali; Renaud, Ronald
2004-10-01
A technique to improve the image quality of stereoscopic pictures generated from depth maps (depth image based rendering or DIBR) is examined. In general, there are two fundamental problems with DIBR: a depth map could contain artifacts (e.g., noise or "blockiness") and there is no explicit information on how to render newly exposed regions ("holes") in the rendered image as a result of new virtual camera positions. We hypothesized that smoothing depth maps before rendering will not only minimize the effects of noise and distortions in the depth maps but will also reduce areas of newly exposed regions where potential artifacts can arise. A formal subjective assessment of four stereoscopic sequences of natural scenes was conducted with 23 viewers. The stereoscopic sequences consisted of source images for the left-eye view and rendered images for the right-eye view. The depth maps were smoothed with a Gaussian blur filter at different levels of strength before depth image based rendering. Results indicated that ratings of perceived image quality improved with increasing levels of smoothing of the depth maps. Even though the depth maps were smoothed, a negative effect on ratings of overall perceived depth quality was not found.
Wave Forces on a Vertical Smooth Cylinder in Directional Waves
DEFF Research Database (Denmark)
Høgedal, M.; Skourup, J.; Burcharth, H. F.
1994-01-01
In this paper the results from physical experiments with an instrumented cylinder conducted in laboratory environments are presented. The primary aim of the study has been to investigate the effect from wave directionality on the local and depth integrated maximum wave forces on a smooth vertical...
Smooth plains on Mercury. A comparison with Vesta.
Zambon, F.; Capaccioni, F.; Carli, C.; De Sanctis, M. C.; Filacchione, G.; Giacomini, L.
Mercury, the closest planet to the Sun, has been visited by the MESSENGER spacecraft \\citet{solomon2007}. After 3 years of orbit around Mercury a global coverage of the surface has been done revealing that ∼27% of Mercury's surface is covered by smooth plains \\citet{denevi2013}. Large part of Mercury's smooth plain (SP) seems to have volcanic origin. Different composition has been observed, most of the SP have a magnesian alkali-basalt-like composition, while some of them have been interpreted as ultramafic. A further 2% of smooth plains have been identified as Odin-type plains and represent the knobby and hummocky plains surrounding the Caloris basin \\citet{denevi2013}. Application of classification methods \\citet{adams2006} applied to color image data of the MESSENGER wide angle camera (MDIS-WAC) \\citet{MDIS} and a spectral analysis of the spec- trometer data (MASCS-VIRS) \\citet{MASCS} are useful to highlight the differences in composition of the smooth planes. A compa rison between Mercury's SP and those of other solar system bodies, such as Vesta \\citet{desanctis2012}, reveals useful to obtain information on the origin and the evolution of this bodies.
SMOOTH SPALLATION RESULTING FROM COLLISIONS OF COPPER PLATES
Zakharenko, I.
1988-01-01
The author examines the processes occuring during the collision of the metal plates with the speed 800-400 m/s. The experiment showed the formation of smooth cracks due to the collision of heat-treated copper plates with equal thickness.
Airway smooth muscle and fibroblasts in the pathogenesis of asthma
Johnson, Peter R A; Burgess, Janette K
2004-01-01
Asthma is a disease characterized by marked structural changes within the airway wall. These changes include deposition of extracellular matrix proteins and an increase in the numbers of airway smooth muscle cells and subepithelial fibroblasts. Both these cell types possess properties that would
A Semiclassical Calculation of Scars for a Smooth Potential
Provost, D; Provost, Daniel; Baranger, Michel
1993-01-01
Bogomolny's formula for energy-smoothed scars is applied for the first time to a non-specific, non-scalable Hamiltonian, a 2-D anharmonic oscillator. The semiclassical theory reproduces well the exact quantal results over a large spatial and energy range.
On a class of smooth Frechet subalgebras of C -algebras
Indian Academy of Sciences (India)
Proc. Indian Acad. Sci. (Math. Sci.) Vol. 123, No. 3, August 2013, pp. 393–413. c Indian Academy of Sciences. On a class of smooth Frechet subalgebras of C. ∗ ... Department of Mathematics, Sardar Patel University, Vallabh Vidyanagar, .... which was further developed in [5] at the level of generality of the present definition.
Launch Environment Water Flow Simulations Using Smoothed Particle Hydrodynamics
Vu, Bruce T.; Berg, Jared J.; Harris, Michael F.; Crespo, Alejandro C.
2015-01-01
This paper describes the use of Smoothed Particle Hydrodynamics (SPH) to simulate the water flow from the rainbird nozzle system used in the sound suppression system during pad abort and nominal launch. The simulations help determine if water from rainbird nozzles will impinge on the rocket nozzles and other sensitive ground support elements.
Water Flow Simulation using Smoothed Particle Hydrodynamics (SPH)
Vu, Bruce; Berg, Jared; Harris, Michael F.
2014-01-01
Simulation of water flow from the rainbird nozzles has been accomplished using the Smoothed Particle Hydrodynamics (SPH). The advantage of using SPH is that no meshing is required, thus the grid quality is no longer an issue and accuracy can be improved.
Postprocessing Fourier spectral methods: The case of smooth solutions
Energy Technology Data Exchange (ETDEWEB)
Garcia-Archilla, B. [Univ. Autonoma de Madrid (Spain). Dept. de Matematicas; Novo, J. [Univ. de Valladolid (Spain). Dept. de Matematica Aplicada y Computacion; Titi, E.S. [Univ. of California, Irvine, CA (United States)
1998-11-01
A postprocessing technique to improve the accuracy of Galerkin methods, when applied to dissipative partial differential equations, is examined in the particular case of smooth solutions. Pseudospectral methods are shown to perform poorly. This performance is analyzed and a refined postprocessing technique is proposed.
Comparative Analysis for Robust Penalized Spline Smoothing Methods
Directory of Open Access Journals (Sweden)
Bin Wang
2014-01-01
Full Text Available Smoothing noisy data is commonly encountered in engineering domain, and currently robust penalized regression spline models are perceived to be the most promising methods for coping with this issue, due to their flexibilities in capturing the nonlinear trends in the data and effectively alleviating the disturbance from the outliers. Against such a background, this paper conducts a thoroughly comparative analysis of two popular robust smoothing techniques, the M-type estimator and S-estimation for penalized regression splines, both of which are reelaborated starting from their origins, with their derivation process reformulated and the corresponding algorithms reorganized under a unified framework. Performances of these two estimators are thoroughly evaluated from the aspects of fitting accuracy, robustness, and execution time upon the MATLAB platform. Elaborately comparative experiments demonstrate that robust penalized spline smoothing methods possess the capability of resistance to the noise effect compared with the nonrobust penalized LS spline regression method. Furthermore, the M-estimator exerts stable performance only for the observations with moderate perturbation error, whereas the S-estimator behaves fairly well even for heavily contaminated observations, but consuming more execution time. These findings can be served as guidance to the selection of appropriate approach for smoothing the noisy data.
beta-Catenin regulates airway smooth muscle contraction
Jansen, Sepp R.; Van Ziel, Anna M.; Baarsma, Hoeke A.; Gosens, Reinoud
Jansen SR, Van Ziel AM, Baarsma HA, Gosens R. beta-Catenin regulates airway smooth muscle contraction. Am J Physiol Lung Cell Mol Physiol 299: L204-L214, 2010. First published May 14, 2010; doi:10.1152/ajplung.00020.2010.-beta-Catenin is an 88-kDa member of the armadillo family of proteins that is
Technique for smoothing free-flight oscillation data.
CSIR Research Space (South Africa)
Beyers, ME
1975-01-01
Full Text Available A technique based on superposition of tricyclic solutions has been proposed for smoothing free-flight angular motion. When incorporated into a conventional tricyclic data reduction program, the method is convenient to use and does not require a...
Adaptive Smoothed Finite Elements (ASFEM) for history dependent material models
Quak, W.; van den Boogaard, Antonius H.; Menary, Gary
2011-01-01
A successful simulation of a bulk forming process with finite elements can be difficult due to distortion of the finite elements. Nodal smoothed Finite Elements (NSFEM) are an interesting option for such a process since they show good distortion insensitivity and moreover have locking-free behavior
Congenital smooth muscle hamartoma of the palpebral conjunctiva.
Mora, L Evelyn; Rodríguez-Reyes, Abelardo A; Vera, Ana M; Rubio, Rosa Isela; Mayorquín-Ruiz, Mariana; Salcedo, Guillermo
2012-01-01
Smooth muscle hamartoma is defined as a disorganized focus or an overgrowth of mature smooth muscle, generally with low capacity of autonomous growth and benign behavior. The implicated tissues are mature and proliferate in a disorganized fashion. A healthy 5-day-old Mexican boy was referred to the authors' hospital in México city for evaluation of a "cystic" lesion of the right eye that had been noted since birth. The pregnancy and delivery were unremarkable. On physical examination, there was a reddish-pink soft lesion with a tender "cystic" appearance, which was probably emerging from the upper eyelid conjunctiva, which measured 2.7 cm in its widest diameter and transilluminated. Ultrasound imaging revealed an anterior "cystic" lesion with normally formed phakic eye. An excisional biopsy was performed, and the lesion was dissected from the upper tarsal subconjunctival space. Subsequent histologic and immunohistochemical findings were consistent with the diagnosis of congenital smooth muscle hamartoma (CSMH) of the tarsal conjunctiva. The authors' research revealed that only one case of CSMH localized in the conjunctiva (Roper GJ, Smith MS, Lueder GT. Congenital smooth muscle hamartoma of the conjunctival fornix. Am J Ophthalmol. 1999;128:643-4) has been reported to date in the literature. To the best of the authors' knowledge, this current case would be the second case reported of CSMH in this anatomic location. Therefore, the authors' recommendation is to include CSMH in the differential diagnosis of a cystic mass that presents in the fornix and palpebral conjunctiva.
Smooth and rough boundaries in turbulent Taylor-Couette flow
van den Berg, Th.H.; Doering, Charles R.; Lohse, Detlef; Lathrop, Daniel P.
2003-01-01
We examine the torque required to drive the smooth or rough cylinders in turbulent Taylor-Couette flow. With rough inner and outer walls the scaling of the dimensionless torque G is found to be consistent with pure Kolmogorov scaling G~Re2. The results are interpreted within the Grossmann-Lohse
Vascular smooth muscle sensitivity to varying oxygen tensions, Bay ...
African Journals Online (AJOL)
I this our study, using rat tail artery activate by nordrenaline and potassium chloride in thepresence of Bay K. 8644 and nifedipine at different oxygen levels, we showed that desensitization of the responses of the vscular smooth muscle occurred. It was evident that the underlying basis of vascular reponses observed with ...
Peptostreptococcus micros smooth and rough genotypes in periodontitis and gingivitis
Kremer, BHA; Loos, BG; van der Velden, U; van Winkelhoff, AJ; Craandijk, J; Bulthuis, HM; Hutter, J; Varoufaki, AS; van Steenbergen, TJM
Background: Two genotypes can be distinguished within the species Peptostreptococcus micros: a smooth (Sm) and a rough (Rg) type. To date no systematic study has been performed on the prevalence and proportion of both types in untreated periodontitis patients and subjects without destructive
An adaptive filter for smoothing noisy radar images
Frost, V. S.; Stiles, J. A.; Shanmugam, K. S.; Holtzman, J. C.; Smith, S. A.
1981-01-01
A spatial domain adaptive Wiener filter for smoothing radar images corrupted by multiplicative noise is presented. The filter is optimum in a minimum mean squared error sense, computationally efficient, and preserves edges in the image better than other filters. The proposed algorithm can also be used for processing optical images with illumination variations that have a multiplicative effect.
Upsilon-quaternion splines for the smooth interpolation of orientations.
Nielson, Gregory M
2004-01-01
We present a new method for smoothly interpolating orientation matrices. It is based upon quaternions and a particular construction of upsilon-spline curves. The new method has tension parameters and variable knot (time) spacing which both prove to be effective in designing and controlling key frame animations.
Smoothed analysis of partitioning algorithms for Euclidean functionals
Bläser, Markus; Manthey, Bodo; Rao, B.V. Raghavendra
2013-01-01
Euclidean optimization problems such as TSP and minimum-length matching admit fast partitioning algorithms that compute near-optimal solutions on typical instances. In order to explain this performance, we develop a general framework for the application of smoothed analysis to partitioning
Smoothed analysis of partitioning algorithms for Euclidean functionals
Bläser, Markus; Manthey, Bodo; Rao, B.V. Raghavendra; Dehne, F.; Iacono, J.; Sack, J.-R.
2011-01-01
Euclidean optimization problems such as TSP and minimum-length matching admit fast partitioning algorithms that compute near-optimal solutions on typical instances. We develop a general framework for the application of smoothed analysis to partitioning algorithms for Euclidean optimization problems.
Mechanism of kolaviron-induced relaxation of rabbit aortic smooth ...
African Journals Online (AJOL)
Mechanism of kolaviron-induced relaxation of rabbit aortic smooth muscle. 1Uche O.K.* Baseerah E.B. 2Anukam C.K.. 1Department of Physiology and 2TWAS Genomic Research Unit, Department of Medical Laboratory Sciences,. School of Basic Medical Sciences, University of Benin, PMB 1154 Benin City, Nigeria.
An Error Detection and Smoothing Algorithm for Infrared Data.
1986-04-01
34A Dynamic Programming Technique for Nonlinear ’R. L. Lucke, A. P. Schaum , J. C. Kershenstein, J. Michalo- Smoothing", Proc. IEEE International Conf...UNIVERSITY APPLIED PHYSICS LABORATORY LAUREL. MARYLAND REFERENCES 1R. L. Lucke, A. P. Schaum , J. C. Kershenstein, J. 7 H. Ney, "A Dynamic Programming
Smooth transition autoregressive models - A survey of recent developments
D.J.C. van Dijk (Dick); T. Terasvirta; Ph.H.B.F. Franses (Philip Hans)
2000-01-01
textabstractThis paper surveys recent developments related to the smooth transition autoregressive [STAR] time series model and several of its variants. We put emphasis on new methods for testing for STAR nonlinearity, model evaluation, and forecasting. Several useful extensions of the basic STAR
Vascular effects of 3-carbomethoxypyridine on rabbit aortic smooth ...
African Journals Online (AJOL)
Background: 3-Carbomethoxypyridine (3-CMP) is a methyl nicotinate that has been isolated and characterized from one of the alkaloidal fractions of Pyrenacantha staudtii. No literature is available on its vascular action. The goal of this study was to characterize the mechanism of action of 3-CMP on rabbit aortic smooth ...
Estimate of K-functionals and modulus of smoothness constructed ...
Indian Academy of Sciences (India)
Introduction and preliminaries. In [2], Belkina and Platonov proved the equivalence theorem for a K-functional and a modulus of smoothness for the Dunkl transform in the Hilbert space L2(R, |x|2α+1. ), α > −1/2, using a Dunkl translation operator. In this paper, we prove the analog of this result (see [2]) in the Hilbert space.
Association of smooth muscle cell tissue factor with caveolae
Mulder, AB; Smit, JW; Bom, VJJ; Blom, NR; Ruiters, MHJ; Halie, MR; vanderMeer, J
1996-01-01
There is still no satisfactory explanation for the low catalytic activity of tissue factor (TF)/factor VII(a) complexes towards coagulation factor X, as found on the apical surface side of cell layers. It has been hypothesized that TF exists in a latent form. Layers of cultured human smooth muscle
Conditional electron confinement in graphene via smooth magnetic fields
Le, Dai-Nam; Le, Van-Hoang; Roy, Pinaki
2018-02-01
In this article we discuss confinement of electrons in graphene via smooth magnetic fields which are finite everywhere on the plane. We shall consider two types of magnetic fields leading to systems which are conditionally exactly solvable and quasi exactly solvable. The bound state energies and wavefunctions in both cases have been found exactly.
Morinda lucida reduces contractility of isolated uterine smooth ...
African Journals Online (AJOL)
The present work investigated the effect of Morinda lucida (M. lucida) extract on isolated uterine smooth muscle of pregnant and non-pregnant mice. Pregnant and non-pregnant mice were pretreated with oral stilboesterol (0.1mg/kg body weight) and killed by cervical dislocation. Thin strips of the uterus were cut and ...
Evaluation of eigenvalues of a smooth potential via Schroedinger ...
Indian Academy of Sciences (India)
Evaluation of eigenvalues of a smooth potential via Schroedinger transmission across multi-step potential. BASUDEB SAHU1,∗, BIDHUBHUSAN SAHU1 and SANTOSH K AGARWALLA2. 1Department of Physics, North Orissa University, Baripada 757 003, India. 2Department of Applied Physics and Ballistics, Fakir Mohan ...
Improving convergence in smoothed particle hydrodynamics simulations without pairing instability
Dehnen, Walter; Aly, Hossam
2012-09-01
The numerical convergence of smoothed particle hydrodynamics (SPH) can be severely restricted by random force errors induced by particle disorder, especially in shear flows, which are ubiquitous in astrophysics. The increase in the number NH of neighbours when switching to more extended smoothing kernels at fixed resolution (using an appropriate definition for the SPH resolution scale) is insufficient to combat these errors. Consequently, trading resolution for better convergence is necessary, but for traditional smoothing kernels this option is limited by the pairing (or clumping) instability. Therefore, we investigate the suitability of the Wendland functions as smoothing kernels and compare them with the traditional B-splines. Linear stability analysis in three dimensions and test simulations demonstrate that the Wendland kernels avoid the pairing instability for all NH, despite having vanishing derivative at the origin (disproving traditional ideas about the origin of this instability; instead, we uncover a relation with the kernel Fourier transform and give an explanation in terms of the SPH density estimator). The Wendland kernels are computationally more convenient than the higher order B-splines, allowing large NH and hence better numerical convergence (note that computational costs rise sublinear with NH). Our analysis also shows that at low NH the quartic spline kernel with NH ≈ 60 obtains much better convergence than the standard cubic spline.
Mechanism of kolaviron-induced relaxation of rabbit aortic smooth ...
African Journals Online (AJOL)
induced relaxation on contractile responses in ring preparations of vascular smooth muscle (VSM) of the rabbit aorta in vitro, in standard laboratory organ bath procedure. Following Phenylephrine (PE) (10-7M), or high-K+ (80 mMK+) PSS induced ...
A remark on smooth images of Banach spaces
Czech Academy of Sciences Publication Activity Database
Hájek, Petr Pavel; Johanis, M.
2018-01-01
Roč. 458, č. 2 (2018), s. 1307-1313 ISSN 0022-247X R&D Projects: GA ČR GA16-07378S Institutional support: RVO:67985840 Keywords : smooth surjections Subject RIV: BA - General Mathematics Impact factor: 1.064, year: 2016 http://www.sciencedirect.com/science/article/pii/S0022247X17309186?via%3Dihub
Smoothed analysis of left-to-right maxima with applications
Damerow, Valentina; Manthey, Bodo; Meyer auf der Heide, Friedhelm; Räcke, Heide Harald; Scheideler, Christian; Sohler, Christian; Tantau, Till
A left-to-right maximum in a sequence of n numbers $s_1, ..., s_n$ is a number that is strictly larger than all preceding numbers. In this paper we present a smoothed analysis of the number of left-to-right maxima in the presence of additive random noise. We show that for every sequence of $n$
Particle motions in oscillatory flow over a smooth bed
DEFF Research Database (Denmark)
Jensen, Karsten Lindegård; Sumer, B. Mutlu; Fredsøe, Jørgen
2014-01-01
This study investigates particle motions near the bed in an oscillating tunnel with a smooth bed. Trajectories of a heavy particle were recorded in two dimensions (horizontal and vertical) and in time. The wave boundary layer Reynolds number is Re = 520000. Kinematical quantities such as the prob...
Phenotype modulation of airway smooth muscle in asthma
Wright, David B.; Trian, Thomas; Siddiqui, Sana; Pascoe, Chris D.; Johnson, Jill R.; Dekkers, Bart G. J.; Dakshinamurti, Shyamala; Bagchi, Rushita; Burgess, Janette K.; Kanabar, Varsha; Ojo, Oluwaseun O.
The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the degree of a variety of functions, including contractility, proliferation, migration and secretion of inflammatory
Airway smooth muscle cells : regulators of airway inflammation
Zuyderduyn, Suzanne
2007-01-01
Airways from asthmatic subjects are more responsive to bronchoconstrictive stimuli than airways from healthy subjects. Airway smooth muscle (ASM) cells mediate contraction of the airways by responding to the bronchoconstrictive stimuli, which was thought to be the primary role of ASM cells. In this
Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice.
Keeler, Allison M; Liu, Donghai; Zieger, Marina; Xiong, Lang; Salemi, Jeffrey; Bellvé, Karl; Byrne, Barry J; Fuller, David D; ZhuGe, Ronghua; ElMallah, Mai K
2017-06-01
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA), an enzyme responsible for hydrolyzing lysosomal glycogen. Deficiency of GAA leads to systemic glycogen accumulation in the lysosomes of skeletal muscle, motor neurons, and smooth muscle. Skeletal muscle and motor neuron pathology are known to contribute to respiratory insufficiency in Pompe disease, but the role of airway pathology has not been evaluated. Here we propose that GAA enzyme deficiency disrupts the function of the trachea and bronchi and this lower airway pathology contributes to respiratory insufficiency in Pompe disease. Using an established mouse model of Pompe disease, the Gaa-/- mouse, we compared histology, pulmonary mechanics, airway smooth muscle (ASM) function, and calcium signaling between Gaa-/- and age-matched wild-type (WT) mice. Lysosomal glycogen accumulation was observed in the smooth muscle of both the bronchi and the trachea in Gaa-/- but not WT mice. Furthermore, Gaa-/- mice had hyporesponsive airway resistance and bronchial ring contraction to the bronchoconstrictive agents methacholine (MCh) and potassium chloride (KCl) and to a bronchodilator (albuterol). Finally, calcium signaling during bronchiolar smooth muscle contraction was impaired in Gaa-/- mice indicating impaired extracellular calcium influx. We conclude that GAA enzyme deficiency leads to glycogen accumulation in the trachea and bronchi and impairs the ability of lower ASM to regulate calcium and respond appropriately to bronchodilator or constrictors. Accordingly, ASM dysfunction may contribute to respiratory impairments in Pompe disease. Copyright © 2017 the American Physiological Society.
HSP20 phosphorylation and airway smooth muscle relaxation
Directory of Open Access Journals (Sweden)
Mariam Ba
2009-06-01
Full Text Available Mariam Ba1, Cherie A Singer1, Manoj Tyagi2, Colleen Brophy3, Josh E Baker4, Christine Cremo4, Andrew Halayko5, William T Gerthoffer21Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA; 2Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, USA; 3Harrington Department of Biochemistry, Arizona State University, Tempe, AZ, USA; 4Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA; 5Departments of Physiology and Internal Medicine, University of Manitoba, Winnipeg, MB, CanadaAbstract: HSP20 (HSPB6 is a small heat shock protein expressed in smooth muscles that is hypothesized to inhibit contraction when phosphorylated by cAMP-dependent protein kinase. To investigate this hypothesis in airway smooth muscle (ASM we showed that HSP20 was constitutively expressed as well as being inducible in cultured hASM cells by treatment with 1 µM isoproterenol or 10 µM salmeterol. In contrast, a mixture of proinflammatory mediators (interleukin-1β, tumor necrosis factor α, and interferon γ inhibited expression of HSP20 by about 50% in 48 hours. To determine whether phosphorylation of HSP20 is sufficient to induce relaxation, canine tracheal smooth muscle was treated with a cell permeant phosphopeptide that mimics the phosphorylation of HSP20. The HSP20 phosphopeptide antagonized carbacholinduced contraction by 60% with no change in myosin light chain phosphorylation. Recombinant full length HSP20 inhibited skeletal actin binding to smooth muscle myosin subfragment 1 (S1, and recombinant cell permeant TAT-HSP20 S16D mutant reduced F-actin filaments in cultured hASM cells. Carbachol stimulation of canine tracheal smooth muscle tissue caused redistribution of HSP20 from large macromolecular complexes (200–500 kDa to smaller complexes (<60 kDa. The results are consistent with HSP20 expression and macromolecular structure being dynamically regulated in airway
Smoothed Spectra, Ogives, and Error Estimates for Atmospheric Turbulence Data
Dias, Nelson Luís
2017-09-01
A systematic evaluation is conducted of the smoothed spectrum, which is a spectral estimate obtained by averaging over a window of contiguous frequencies. The technique is extended to the ogive, as well as to the cross-spectrum. It is shown that, combined with existing variance estimates for the periodogram, the variance—and therefore the random error—associated with these estimates can be calculated in a straightforward way. The smoothed spectra and ogives are biased estimates; with simple power-law analytical models, correction procedures are devised, as well as a global constraint that enforces Parseval's identity. Several new results are thus obtained: (1) The analytical variance estimates compare well with the sample variance calculated for the Bartlett spectrum and the variance of the inertial subrange of the cospectrum is shown to be relatively much larger than that of the spectrum. (2) Ogives and spectra estimates with reduced bias are calculated. (3) The bias of the smoothed spectrum and ogive is shown to be negligible at the higher frequencies. (4) The ogives and spectra thus calculated have better frequency resolution than the Bartlett spectrum, with (5) gradually increasing variance and relative error towards the low frequencies. (6) Power-law identification and extraction of the rate of dissipation of turbulence kinetic energy are possible directly from the ogive. (7) The smoothed cross-spectrum is a valid inner product and therefore an acceptable candidate for coherence and spectral correlation coefficient estimation by means of the Cauchy-Schwarz inequality. The quadrature, phase function, coherence function and spectral correlation function obtained from the smoothed spectral estimates compare well with the classical ones derived from the Bartlett spectrum.
Full-waveform inversion using a nonlinearly smoothed wavefield
Li, Yuanyuan
2017-12-08
Conventional full-waveform inversion (FWI) based on the least-squares misfit function faces problems in converging to the global minimum when using gradient methods because of the cycle-skipping phenomena. An initial model producing data that are at most a half-cycle away from the observed data is needed for convergence to the global minimum. Low frequencies are helpful in updating low-wavenumber components of the velocity model to avoid cycle skipping. However, low enough frequencies are usually unavailable in field cases. The multiplication of wavefields of slightly different frequencies adds artificial low-frequency components in the data, which can be used for FWI to generate a convergent result and avoid cycle skipping. We generalize this process by multiplying the wavefield with itself and then applying a smoothing operator to the multiplied wavefield or its square to derive the nonlinearly smoothed wavefield, which is rich in low frequencies. The global correlation-norm-based objective function can mitigate the dependence on the amplitude information of the nonlinearly smoothed wavefield. Therefore, we have evaluated the use of this objective function when using the nonlinearly smoothed wavefield. The proposed objective function has much larger convexity than the conventional objective functions. We calculate the gradient of the objective function using the adjoint-state technique, which is similar to that of the conventional FWI except for the adjoint source. We progressively reduce the smoothing width applied to the nonlinear wavefield to naturally adopt the multiscale strategy. Using examples on the Marmousi 2 model, we determine that the proposed FWI helps to generate convergent results without the need for low-frequency information.
Rouhi, Amirreza; Chung, Daniel; Hutchins, Nicholas
2017-11-01
Direct numerical simulations (DNSs) are reported for open channel flow over streamwise-alternating patches of smooth and fully rough walls. Owing to the streamwise periodicity, the flow configuration is composed of a step change from smooth to rough, and a step change from rough to smooth. The friction Reynolds number varies from 443 over the smooth patch to 715 over the rough patch. The flow is thoroughly studied by mean and fluctuation profiles, and spectrograms. The detailed flow from DNS reveals discrepancies of up to 50% among the various definitions of the internal-layer thickness, with apparent power-law exponents differing by up to 60%. The definition based on the logarithmic slope of the velocity profile, as proposed by Chamorro et al. (Boundary-Layer Meteorol., vol. 130, 2009, pp. 29-41), is most consistent with the physical notion of the internal layer; this is supported by the defect similarity based on this internal-layer thickness, and the streamwise homogeneity of the dissipation length-scale within this internal layer. The statistics inside this internal-layer, and the growth of the internal layer itself, are minimally affected by the streamwise periodicity when the patch length is at least six times the channel height.
Image decomposition: separation of texture from piecewise smooth content
Starck, Jean-Luc; Elad, Mikael; Donoho, David L.
2003-11-01
This paper presents a novel method for separating images into texture and piecewise smooth parts. The proposed approach is based on a combination of the Basis Pursuit Denoising (BPDN) algorithm and the Total-Variation (TV) regularization scheme. The basic idea promoted in this paper is the use of two appropriate dictionaries, one for the representation of textures, and the other for the natural scene parts. Each dictionary is designed for sparse representation of a particular type of image-content (either texture or piecewise smooth). The use of BPDN with the two augmented dictionaries leads to the desired separation, along with noise removal as a by-product. As the need to choose a proper dictionary for natural scene is very hard, a TV regularization is employed to better direct the separation process. Experimental results validate the algorithm's performance.
Modelling free surface flows with smoothed particle hydrodynamics
Directory of Open Access Journals (Sweden)
L.Di G.Sigalotti
2006-01-01
Full Text Available In this paper the method of Smoothed Particle Hydrodynamics (SPH is extended to include an adaptive density kernel estimation (ADKE procedure. It is shown that for a van der Waals (vdW fluid, this method can be used to deal with free-surface phenomena without difficulties. In particular, arbitrary moving boundaries can be easily handled because surface tension is effectively simulated by the cohesive pressure forces. Moreover, the ADKE method is seen to increase both the accuracy and stability of SPH since it allows the width of the kernel interpolant to vary locally in a way that only the minimum necessary smoothing is applied at and near free surfaces and sharp fluid-fluid interfaces. The method is robust and easy to implement. Examples of its resolving power are given for both the formation of a circular liquid drop under surface tension and the nonlinear oscillation of excited drops.
Smoothed particle hydrodynamics method from a large eddy simulation perspective
Di Mascio, A.; Antuono, M.; Colagrossi, A.; Marrone, S.
2017-03-01
The Smoothed Particle Hydrodynamics (SPH) method, often used for the modelling of the Navier-Stokes equations by a meshless Lagrangian approach, is revisited from the point of view of Large Eddy Simulation (LES). To this aim, the LES filtering procedure is recast in a Lagrangian framework by defining a filter that moves with the positions of the fluid particles at the filtered velocity. It is shown that the SPH smoothing procedure can be reinterpreted as a sort of LES Lagrangian filtering, and that, besides the terms coming from the LES convolution, additional contributions (never accounted for in the SPH literature) appear in the equations when formulated in a filtered fashion. Appropriate closure formulas are derived for the additional terms and a preliminary numerical test is provided to show the main features of the proposed LES-SPH model.
Smooth Horizonless Geometries Deep Inside the Black-Hole Regime.
Bena, Iosif; Giusto, Stefano; Martinec, Emil J; Russo, Rodolfo; Shigemori, Masaki; Turton, David; Warner, Nicholas P
2016-11-11
We construct the first family of horizonless supergravity solutions that have the same mass, charges, and angular momenta as general supersymmetric rotating D1-D5-P black holes in five dimensions. This family includes solutions with arbitrarily small angular momenta, deep within the regime of quantum numbers and couplings for which a large classical black hole exists. These geometries are well approximated by the black-hole solution, and in particular exhibit the same near-horizon throat. Deep in this throat, the black-hole singularity is resolved into a smooth cap. We also identify the holographically dual states in the N=(4,4) D1-D5 orbifold conformal field theory (CFT). Our solutions are among the states counted by the CFT elliptic genus, and provide examples of smooth microstate geometries within the ensemble of supersymmetric black-hole microstates.
Stochastic clustered-dot screen design for improved smoothness
Gupta, Madhur; Goyal, Puneet; Fischer, Mani; Staelin, Carl; Kashti, Tamar; Shacham, Omri; Allebach, Jan
2011-01-01
Printers employing electrophotographic technology typically use clustered-dot screening to avoid potential artifacts caused by unstable dot rendering. Periodic clustered-dot screens are quite smooth, but also suffer from periodic moiŕe artifacts due to interference with other color channels. Stochastic, clustered-dot screens provide an alternative solution. In this paper, we introduce a new approach for stochastic, clustered-dot screen design based on Direct Binary Search (DBS). The method differs from the conventional DBS in its use of a modified cost metric which was derived in an earlier work from using different filters in the initialization and update phases of DBS. The objective of the chosen approach is to design screen for improved print smoothness by generating a homogeneous distribution of compact, uniformly-sized clusters. The results include halftone of a screened folded-ramp, compared against a screen designed with a previous method.
Uremia modulates the phenotype of aortic smooth muscle cells
DEFF Research Database (Denmark)
Madsen, Marie; Pedersen, Annemarie Aarup; Albinsson, Sebastian
2017-01-01
BACKGROUND AND AIMS: Chronic kidney disease leads to uremia and markedly accelerates atherosclerosis. Phenotypic modulation of smooth muscle cells (SMCs) in the arterial media plays a key role in accelerating atherogenesis. The aim of this study was to investigate whether uremia per se modulates...... the phenotype of aortic SMCs in vivo. METHODS: Moderate uremia was induced by 5/6 nephrectomy in apolipoprotein E knockout (ApoE(-/-)) and wildtype C57Bl/6 mice. Plasma analysis, gene expression, histology, and myography were used to determine uremia-mediated changes in the arterial wall. RESULTS: Induction...... in the aortic media. In the aortic arch, mRNA and miRNA expression patterns were consistent with a uremia-mediated phenotypic modulation of SMCs; e.g. downregulation of myocardin, α-smooth muscle actin, and transgelin; and upregulation of miR146a. Notably, these expression patterns were observed after acute (2...
A new insight into the consistency of smoothed particle hydrodynamics
Sigalotti, Leonardo Di G; Klapp, Jaime; Vargas, Carlos A; Campos, Kilver
2016-01-01
In this paper the problem of consistency of smoothed particle hydrodynamics (SPH) is solved. A novel error analysis is developed in $n$-dimensional space using the Poisson summation formula, which enables the treatment of the kernel and particle approximation errors in combined fashion. New consistency integral relations are derived for the particle approximation which correspond to the cosine Fourier transform of the classically known consistency conditions for the kernel approximation. The functional dependence of the error bounds on the SPH interpolation parameters, namely the smoothing length $h$ and the number of particles within the kernel support ${\\cal{N}}$ is demonstrated explicitly from which consistency conditions are seen to follow naturally. As ${\\cal{N}}\\to\\infty$, the particle approximation converges to the kernel approximation independently of $h$ provided that the particle mass scales with $h$ as $m\\propto h^{\\beta}$, with $\\beta >n$. This implies that as $h\\to 0$, the joint limit $m\\to 0$, $...
Calcium-antagonist effects of quercetin on aortic smooth muscle.
Morales, M A; Lozoya, X
1994-08-01
Relaxation induced by quercetin was studied on aortic rings depolarized with KCl and on Ca2+ dependent aortic contraction. Quercetin's actions as a cyclooxygenase inhibitor were compared with those of indomethacin. To determine the possible effects of quercetin on internal Ca2+ mobilization, it was assayed on aortic muscle contracted with caffeine. Quercetin relaxes aortic smooth muscle contracted with KCl (RC50 = 1.8 x 10(-4) M) and induces a rightward displacement of Ca2+ curves. The relaxation induced by quercetin is higher than that produced by indomethacin, suggesting that its action is independent of cyclooxygenase inhibition. Caffeine-induced aortic contraction was not modified by quercetin, suggesting that its effect should not involve internal calcium modulation. Our results further support the thesis that the spasmolytic action of quercetin arises from its negative modulation of calcium entry to the smooth muscle.
A generalized transport-velocity formulation for smoothed particle hydrodynamics
Zhang, Chi; Hu, Xiangyu Y.; Adams, Nikolaus A.
2017-05-01
The standard smoothed particle hydrodynamics (SPH) method suffers from tensile instability. In fluid-dynamics simulations this instability leads to particle clumping and void regions when negative pressure occurs. In solid-dynamics simulations, it results in unphysical structure fragmentation. In this work the transport-velocity formulation of Adami et al. (2013) [14] is generalized for providing a solution of this long-standing problem. Other than imposing a global background pressure, a variable background pressure is used to modify the particle transport velocity and eliminate the tensile instability completely. Furthermore, such a modification is localized by defining a shortened smoothing length. The generalized formulation is suitable for fluid and solid materials with and without free surfaces. The results of extensive numerical tests on both fluid and solid dynamics problems indicate that the new method provides a unified approach for multi-physics SPH simulations.
A generalized transport-velocity formulation for smoothed particle hydrodynamics
Energy Technology Data Exchange (ETDEWEB)
Zhang, Chi; Hu, Xiangyu Y., E-mail: xiangyu.hu@tum.de; Adams, Nikolaus A.
2017-05-15
The standard smoothed particle hydrodynamics (SPH) method suffers from tensile instability. In fluid-dynamics simulations this instability leads to particle clumping and void regions when negative pressure occurs. In solid-dynamics simulations, it results in unphysical structure fragmentation. In this work the transport-velocity formulation of Adami et al. (2013) is generalized for providing a solution of this long-standing problem. Other than imposing a global background pressure, a variable background pressure is used to modify the particle transport velocity and eliminate the tensile instability completely. Furthermore, such a modification is localized by defining a shortened smoothing length. The generalized formulation is suitable for fluid and solid materials with and without free surfaces. The results of extensive numerical tests on both fluid and solid dynamics problems indicate that the new method provides a unified approach for multi-physics SPH simulations.
Sarcoglycan subcomplex expression in normal human smooth muscle.
Anastasi, Giuseppe; Cutroneo, Giuseppina; Sidoti, Antonina; Rinaldi, Carmen; Bruschetta, Daniele; Rizzo, Giuseppina; D'Angelo, Rosalia; Tarone, Guido; Amato, Aldo; Favaloro, Angelo
2007-08-01
The sarcoglycan complex (SGC) is a multimember transmembrane complex interacting with other members of the dystrophin-glycoprotein complex (DGC) to provide a mechanosignaling connection from the cytoskeleton to the extracellular matrix. The SGC consists of four proteins (alpha, beta, gamma, and delta). A fifth sarcoglycan subunit, epsilon-sarcoglycan, shows a wider tissue distribution. Recently, a novel sarcoglycan, the zeta-sarcoglycan, has been identified. All reports about the structure of SGC showed a common assumption of a tetrameric arrangement of sarcoglycans. Addressing this issue, our immunofluorescence and molecular results showed, for the first time, that all sarcoglycans are always detectable in all observed samples. Therefore, one intriguing possibility is the existence of a pentameric or hexameric complex considering zeta-sarcoglycan of SGC, which could present a higher or lower expression of a single sarcoglycan in conformity with muscle type--skeletal, cardiac, or smooth--or also in conformity with the origin of smooth muscle.
Menthol inhibiting parasympathetic function of tracheal smooth muscle.
Wang, Hsing-Won; Liu, Shao-Cheng; Chao, Pin-Zhir; Lee, Fei-Peng
2016-01-01
Menthol is used as a constituent of food and drink, tobacco and cosmetics nowadays. This cold receptor agonist has been used as a nasal inhalation solution in the daily life. The effect of menthol on nasal mucosa in vivo is well known; however, the effect of the drug on tracheal smooth muscle has been rarely explored. Therefore, during administration of the drug for nasal symptoms, it might also affect the trachea via oral intake or inhalation. We used our preparation to test the effectiveness of menthol on isolated rat tracheal smooth muscle. A 5 mm long portion of rat trachea was submersed in 30 ml Krebs solution in a muscle bath at 37ºC. Changes in tracheal contractility in response to the application of a parasympathetic mimetic agent were measured using a transducer connected to a Pentium III computer equipped with polygraph software. The following assessments of menthol were performed: (1) effect on tracheal smooth muscle resting tension; (2) effect on contraction caused by 10 -6 M methacholine as a parasympathetic mimetic; (3) effect of the drug on electrically induced tracheal smooth muscle contractions. Results indicated that addition of a parasympathetic mimetic to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of menthol at doses of 10 -5 M or above elicited a relaxation response to 10 -6 M methacholine-induced contraction. Menthol could also inhibit electrical field stimulation (EFS) induced spike contraction. However, it alone had a minimal effect on the basal tension of trachea as the concentration increased. We concluded that the degree of drug-induced tracheal contraction or relaxation was dose-dependent. In addition, this study indicated that high concentrations of menthol might actually inhibit parasympathetic function of the trachea.
3D Reconstruction of Coronary Artery Vascular Smooth Muscle Cells
Tong Luo; Huan Chen; Kassab, Ghassan S.
2016-01-01
Aims The 3D geometry of individual vascular smooth muscle cells (VSMCs), which are essential for understanding the mechanical function of blood vessels, are currently not available. This paper introduces a new 3D segmentation algorithm to determine VSMC morphology and orientation. Methods and Results A total of 112 VSMCs from six porcine coronary arteries were used in the analysis. A 3D semi-automatic segmentation method was developed to reconstruct individual VSMCs from cell clumps as well a...
Metal diffusion in smoothed particle hydrodynamics simulations of dwarf galaxies
Williamson, David John; Martel, Hugo; Kawata, Daisuke
2016-01-01
We perform a series of smoothed particle hydrodynamics simulations of isolated dwarf galaxies to compare different metal mixing models. In particular, we examine the role of diffusion in the production of enriched outflows, and in determining the metallicity distributions of gas and stars. We investigate different diffusion strengths, by changing the pre-factor of the diffusion coefficient, by varying how the diffusion coefficient is calculated from the local velocity distribution, and by var...
Superluminal tunneling of microwaves in smoothly varying transmission lines.
Shvartsburg, A B; Marklund, M; Brodin, G; Stenflo, L
2008-07-01
Tunneling of microwaves through a smooth barrier in a transmission line is considered. In contrast to standard wave barriers, we study the case where the dielectric permittivity is positive, and the barrier is caused by the inhomogeneous dielectric profile. It is found that reflectionless, superluminal tunneling can take place for waves with a finite spectral width. The consequences of these findings are discussed, and an experimental setup testing our predictions is proposed.
Chaos and Exponentially Localized Eigenstates in Smooth Hamiltonian Systems
Santhanam, M S; Lakshminarayan, A
1998-01-01
We present numerical evidence to show that the wavefunctions of smooth classically chaotic Hamiltonian systems scarred by certain simple periodic orbits are exponentially localized in the space of unperturbed basis states. The degree of localization, as measured by the information entropy, is shown to be correlated with the local phase space structure around the scarring orbit; indicating sharp localization when the orbit undergoes a pitchfork bifurcation and loses stability.
Blink effects on ongoing smooth pursuit eye movements in humans.
Rambold, Holger; El Baz, Ieman; Helmchen, Christoph
2005-02-01
Blinks are known to affect eye movements, e.g., saccades, slow and fast vergence, and saccade-vergence interaction, in two ways: by superimposition of blink-associated eye movements and changes of the central premotor activity in the brainstem. The goal of this study was to determine, for the first time, the effects of trigeminal evoked blinks on ongoing smooth pursuit eye movements which could be related to visual sensory or premotor neuronal changes. This was compared to the effect of a target disappearing for 100-300 ms duration during ongoing smooth pursuit (blank paradigm) in order to control for the visual sensory effects of a blink. Eye and blink movements were recorded in eight healthy subjects with the scleral search coil technique. Blink-associated eye movements during the first 50% of the blink duration were non-linearly superimposed on the smooth pursuit eye movements. Immediately after the blink-associated eye movements, the pursuit velocity slowly decreased by an average of 3.2+/-2.1 degrees /s. This decrease was not dependent on the stimulus direction. The pursuit velocity decrease caused by blinks which occluded the pupil more than 50% could be explained mostly by blanking the visual target. However, small blinks that did not occlude the pupil (smooth pursuit velocity. Thus, this blink effect on pursuit velocity cannot be explained by blink-associated eye movements or by the blink having blanked the visual input. We propose that part of this effect might either be caused by incomplete visual suppression during blinks and/or a change in the activity of omnipause neurons.
Entering PIN codes by smooth pursuit eye movements
Cymek, Dietlind Helene; Venjakob, Antje Christine; Ruff, Stefan; Lutz, Otto Hans-Martin; Hofmann, Simon; Roetting, Matthias
2014-01-01
Despite its potential gaze interaction is still not a widely-used interaction concept. Major drawbacks as the calibration, strain of the eyes and the high number of false alarms are associated with gaze based interaction and limit its practicability for every-day human computer interaction. In this paper two experiments are described which use smooth pursuit eye movements on moving display buttons. The first experiment was conducted to extract an easy and fast interaction concept and at the s...
Smoothed particle hydrodynamics modelling of fluids and solids
Directory of Open Access Journals (Sweden)
Lobovský L.
2007-11-01
Full Text Available The study is concerned about the application of the smoothed particle hydrodynamics (SPH method within the computational fluid dynamics and elastodynamics. A brief description of the SPH model for an incompressible fluid and for an elastic solid is presented. The implemented model of incompressible fluid is tested for internal flows as well as for flows involving a free surface of the fluid. The implemented elastic solid model is examined during the simulation of the mechanical response of rubber rings.
Radial Basis Function Based Quadrature over Smooth Surfaces
2016-03-24
Stieltjessche Integrale und Harmonische Analyse,” Math . Ann., vol. 108, pp. 378–410, 1933. 12. I. J. Schoenberg, “Metric Spaces and Positive Definite Functions ...Fornberg, “Interpolation in the Limit of Increasingly Flat Radial Basis Functions ,” Comput. Math . Appl., vol. 43, pp. 413–422, 2002. 83 REPORT...Radial Basis Function Based Quadrature over Smooth Surfaces THESIS March 2016 Maloupu L. Watts, Second Lieutenant, USAF AFIT-ENC-MS-16-M-003
Accurate Position Estimation in Switched Reluctance Motor With Smooth Starting
Panda, Debiprasad; Ramarayanan, V
2000-01-01
This paper presents a novel method of position estimation for switched reluctance (SR) motors. The method is suitable from starting to full speed. It ensures smooth starting without initial hesitation. The method further proposes a better position estimating algorithm incorporating corrections for eddy current and mutual inductance effects. The algorithm is better suited in a digital control platform for its realisation. In the present work, a Texas Instruments made DSP (TMS320c50) is used fo...
Experimental model of human corpus cavernosum smooth muscle relaxation
Regadas, Rommel P.; Maria E. A. Moraes; Mesquita,Francisco J. C.; Joao B. G. Cerqueira; Gonzaga-Silva,Lucio F.
2010-01-01
PURPOSE: To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. MATERIALS AND METHODS: The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra) was isolated and placed in ice-cold sterile transportation buffer. Under magnification, the cavernous artery was dissected. Th...
A Robust Kalman Framework with Resampling and Optimal Smoothing
Thomas Kautz; Bjoern M. Eskofier
2015-01-01
The Kalman filter (KF) is an extremely powerful and versatile tool for signal processing that has been applied extensively in various fields. We introduce a novel Kalman-based analysis procedure that encompasses robustness towards outliers, Kalman smoothing and real-time conversion from non-uniformly sampled inputs to a constant output rate. These features have been mostly treated independently, so that not all of their benefits could be exploited at the same time. Here, we present a coherent...
Liquid-Infused Smooth Surface for Improved Condensation Heat Transfer.
Tsuchiya, Hirotaka; Tenjimbayashi, Mizuki; Moriya, Takeo; Yoshikawa, Ryohei; Sasaki, Kaichi; Togasawa, Ryo; Yamazaki, Taku; Manabe, Kengo; Shiratori, Seimei
2017-09-12
Control of vapor condensation properties is a promising approach to manage a crucial part of energy infrastructure conditions. Heat transfer by vapor condensation on superhydrophobic coatings has garnered attention, because dropwise condensation on superhydrophobic surfaces with rough structures leads to favorable heat-transfer performance. However, pinned condensed water droplets within the rough structure and a high thermodynamic energy barrier for nucleation of superhydrophobic surfaces limit their heat-transfer increase. Recently, slippery liquid-infused surfaces (SLIPS) have been investigated, because of their high water sliding ability and surface smoothness originating from the liquid layer. However, even on SLIPS, condensed water droplets are eventually pinned to degrade their heat-transfer properties after extended use, because the rough base layer is exposed as infused liquid is lost. Herein, we report a liquid-infused smooth surface named "SPLASH" (surface with π electron interaction liquid adsorption, smoothness, and hydrophobicity) to overcome the problems derived from the rough structures in previous approaches to obtain stable, high heat-transfer performance. The SPLASH displayed a maximum condensation heat-transfer coefficient that was 175% higher than that of an uncoated substrate. The SPLASH also showed higher heat-transfer performance and more stable dropwise condensation than superhydrophobic surfaces and SLIPS from the viewpoints of condensed water droplet mobility and the thermodynamic energy barrier for nucleation. The effects of liquid-infused surface roughness and liquid viscosity on condensation heat transfer were investigated to compare heat-transfer performance. This research will aid industrial applications using vapor condensation.
Efficient estimation of smooth distributions from coarsely grouped data.
Rizzi, Silvia; Gampe, Jutta; Eilers, Paul H C
2015-07-15
Ungrouping binned data can be desirable for many reasons: Bins can be too coarse to allow for accurate analysis; comparisons can be hindered when different grouping approaches are used in different histograms; and the last interval is often wide and open-ended and, thus, covers a lot of information in the tail area. Age group-specific disease incidence rates and abridged life tables are examples of binned data. We propose a versatile method for ungrouping histograms that assumes that only the underlying distribution is smooth. Because of this modest assumption, the approach is suitable for most applications. The method is based on the composite link model, with a penalty added to ensure the smoothness of the target distribution. Estimates are obtained by maximizing a penalized likelihood. This maximization is performed efficiently by a version of the iteratively reweighted least-squares algorithm. Optimal values of the smoothing parameter are chosen by minimizing Akaike's Information Criterion. We demonstrate the performance of this method in a simulation study and provide several examples that illustrate the approach. Wide, open-ended intervals can be handled properly. The method can be extended to the estimation of rates when both the event counts and the exposures to risk are grouped. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.
Ensemble Kalman filtering with one-step-ahead smoothing
Raboudi, Naila F.
2018-01-11
The ensemble Kalman filter (EnKF) is widely used for sequential data assimilation. It operates as a succession of forecast and analysis steps. In realistic large-scale applications, EnKFs are implemented with small ensembles and poorly known model error statistics. This limits their representativeness of the background error covariances and, thus, their performance. This work explores the efficiency of the one-step-ahead (OSA) smoothing formulation of the Bayesian filtering problem to enhance the data assimilation performance of EnKFs. Filtering with OSA smoothing introduces an updated step with future observations, conditioning the ensemble sampling with more information. This should provide an improved background ensemble in the analysis step, which may help to mitigate the suboptimal character of EnKF-based methods. Here, the authors demonstrate the efficiency of a stochastic EnKF with OSA smoothing for state estimation. They then introduce a deterministic-like EnKF-OSA based on the singular evolutive interpolated ensemble Kalman (SEIK) filter. The authors show that the proposed SEIK-OSA outperforms both SEIK, as it efficiently exploits the data twice, and the stochastic EnKF-OSA, as it avoids observational error undersampling. They present extensive assimilation results from numerical experiments conducted with the Lorenz-96 model to demonstrate SEIK-OSA’s capabilities.
Background Subtraction of Raman Spectra Based on Iterative Polynomial Smoothing.
Wang, Tuo; Dai, Liankui
2017-06-01
In this paper, a novel background subtraction algorithm is presented that can automatically recover Raman signal. This algorithm is based on an iterative polynomial smoothing method that highly reduces the need for experience and a priori knowledge. First, a polynomial filter is applied to smooth the input spectrum (the input spectrum is just an original spectrum at the first iteration). The output curve of the filter divides the original spectrum into two parts, top and bottom. Second, a proportion is calculated between the lowest point of the signal in the bottom part and the highest point of the signal in the top part. The proportion is a key index that decides whether to go into a new iteration. If a new iteration is needed, the minimum value between the output curve and the original spectrum forms a new curve that goes into the same filter in the first step and continues as another iteration until no more iteration is needed to finally get the background of the original spectrum. Results from the simulation experiments not only show that the iterative polynomial smoothing algorithm achieves good performance, processing time, cost, and accuracy of recovery, but also prove that the algorithm adapts to different background types and a large signal-to-noise ratio range. Furthermore, real measured Raman spectra of organic mixtures and non-organic samples are used to demonstrate the application of the algorithm.
Potassium currents in cultured human pulmonary arterial smooth muscle cells.
Peng, W; Karwande, S V; Hoidal, J R; Farrukh, I S
1996-04-01
In this study, using whole cell and single-channel configurations of the patch-clamp technique, we characterized K+ currents (IK) in cultured human pulmonary arterial smooth muscle cells. The net whole cell outward membrane current (IKo) was activated at potentials positive to -60 mV. One component of IKo, IK(dr), was inhibited by 4-aminopyridine (4-AP) and high concentrations of tetraethylammonium (TEA) but was Ca2+ and charybdotoxin (CTX) insensitive. The other component of IKo, IK(Ca), was voltage and Ca2+ dependent and was inhibited by CTX and low concentrations of TEA. Activation of IKo in single-channel recordings was voltage dependent and demonstrated a high-conductance channel (245 +/- 2 pS) that was Ca2+ and CTX sensitive [IK(Ca)] and a low-conductance channel (109 +/- 2 pS) that was inhibited by 4-AP [IK(dr)] but was insensitive to low concentrations of TEA or to an increase in intracellular [Ca2+]. In isolated pulmonary arterial rings, TEA and 4-AP caused an additive increase in arterial tension. To our knowledge these data provide the first characterization of the IK in human pulmonary arterial smooth muscle cells and indicate that IK(Ca) and IK(dr) play an important role in maintaining pulmonary vascular tone. The data confirm previous observations in pulmonary smooth muscle cells of animal models.
Experimental model of human corpus cavernosum smooth muscle relaxation
Directory of Open Access Journals (Sweden)
Rommel P. Regadas
2010-08-01
Full Text Available PURPOSE: To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. MATERIALS AND METHODS: The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra was isolated and placed in ice-cold sterile transportation buffer. Under magnification, the cavernous artery was dissected. Thus, 2 cm fragments of cavernous artery and corpus cavernosum were obtained. Strips measuring 3 x 3 x 8 mm3 were then mounted vertically in an isolated organ bath device. Contractions were measured isometrically with a Narco-Biosystems force displacement transducer (model F-60, Narco-Biosystems, Houston, TX, USA and recorded on a 4-channel Narco-Biosystems desk model polygraph. RESULTS: Phenylephrine (1µM was used to induce tonic contractions in the corpus cavernosum (3 - 5 g tension and cavernous artery (0.5 - 1g tension until reaching a plateau. After precontraction, smooth muscle relaxants were used to produce relaxation-response curves (10-12M to 10-4 M. Sodium nitroprusside was used as a relaxation control. CONCLUSION: The harvesting technique and the smooth muscle contraction-relaxation model described in this study were shown to be useful instruments in the search for new drugs for the treatment of human erectile dysfunction.
Skeletal, cardiac, and smooth muscle failure in Duchenne muscular dystrophy.
Boland, B J; Silbert, P L; Groover, R V; Wollan, P C; Silverstein, M D
1996-01-01
The goals of this study were to describe the clinical course of skeletal, cardiac, and gastrointestinal muscle manifestations and trends in age at diagnosis and survival of Duchenne muscular dystrophy (DMD) patients. A retrospective cohort of 33 male patients with DMD, born between 1953 and 1983 and followed at the Mayo Clinic during their second decade of life, was studied. The mean age at DMD diagnosis was 4.6 years. Skeletal muscle weakness present in all patients at diagnosis progressed to wheelchair dependency in 32 patients (97%) by the age of 13 years (median age 10 years). Cardiac muscle failure developed in 5 patients (15%) (median age 21.5 years). Smooth muscle manifestations related to the digestive and urinary tracts occurred in 7 (21%) and 2 (6%) patients (median age 15 years), respectively. The gastrointestinal dilatations were primary in 2 patients or secondary to surgery or acute respiratory illness in 5 patients. By the end of the study period, 17 deaths had occurred (median age 17 years). Over time, there was a decrease in the time to DMD diagnosis (P = .05) but no significant change in survival (P = .44). Cardiac and smooth muscle manifestations occur late in the course of DMD. Clinical gastrointestinal symptoms related to smooth muscle function most often were secondary to surgery or a respiratory illness. In recent years, the diagnosis of DMD has been made at a younger age, but survival has not changed.
Lysyl Oxidase Propeptide Inhibits Smooth Muscle Cell Signaling and Proliferation
Hurtado, Paola A.; Vora, Siddharth; Sume, Siddika Selva; Yang, Dan; St. Hilaire, Cynthia; Guo, Ying; Palamakumbura, Amitha H.; Schreiber, Barbara M.; Ravid, Katya; Trackman, Philip C.
2008-01-01
Lysyl oxidase is required for the normal biosynthesis and maturation of collagen and elastin. It is expressed by vascular smooth muscle cells, and its increased expression has been previously found in atherosclerosis and in models of balloon angioplasty. The lysyl oxidase propeptide (LOX-PP) has more recently been found to have biological activity as a tumor suppressor, and it inhibits Erk1/2 Map kinase activation. We reasoned that LOX-PP may have functions in normal non-transformed cells. We, therefore, investigated its effects on smooth muscle cells, focusing on important biological processes mediated by Erk1/2-dependent signaling pathways including proliferation and matrix metalloproteinase-9 (MMP-9) expression. In addition, we investigated whether evidence for accumulation of LOX-PP could be found in vivo in a femoral artery injury model. Recombinant LOX-PP was expressed and purified, and was found to inhibit primary rat aorta smooth muscle cell proliferation and DNA synthesis by more than 50%. TNF-α-stimulated MMP-9 expression and Erk1/2 activation were both significantly inhibited by LOX-PP. Immunohistochemistry studies carried out with affinity purified anti-LOX-PP antibody showed that LOX-PP epitopes were expressed at elevated levels in vascular lesions of injured arteries. These novel data suggest that LOX-PP may provide a feedback control mechanism that serves to inhibit properties associated with the development of vascular pathology. PMID:18060869
Thapsigargin induces apoptosis in cultured human aortic smooth muscle cells.
Peiró, C; Vallejo, S; Cercas, E; Llergo, J L; Lafuente, N; Matesanz, N; Rodríguez-Mañas, L; Sánchez-Ferrer, C F
2000-11-01
Vascular remodeling is a key feature of many pathologic states, including atherosclerosis, or hypertension. Vascular smooth muscle cells participate in determining the vessel structure by several mechanisms such as cell migration, cell growth, or cell death (necrosis or apoptosis). Here we report that thapsigargin, an inhibitor of endoplasmic reticulum Ca2+ -adenosine triphosphatase (ATPase), is able to induce apoptosis in human vascular smooth muscle cells (HVSMCs). Apoptosis was assessed by three different methods: differential chromatin binding dye staining. cytoplasmic histone-associated DNA fragments detection by enzyme-linked immunosorbent assay (ELISA) and terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). When HVSMCs were treated for 1 h with thapsigargin (100 nM-10 microM), there was a concentration-dependent increase in both parameters 24 h after the thapsigargin pulse. When a time-course experiment was performed, both parameters were significantly enhanced from 3 to 6 h after the exposure to thapsigargin. We conclude that thapsigargin promotes apoptosis in HVSMCs, providing a useful tool for the study of programmed cell death in human vascular smooth muscle.
Experimental model of human corpus cavernosum smooth muscle relaxation.
Regadas, Rommel P; Moraes, Maria E A; Mesquita, Francisco J C; Cerqueira, Joao B G; Gonzaga-Silva, Lucio F
2010-01-01
To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra) was isolated and placed in ice-cold sterile transportation buffer. Under magnification, the cavernous artery was dissected. Thus, 2 cm fragments of cavernous artery and corpus cavernosum were obtained. Strips measuring 3 x 3 x 8 mm(3) were then mounted vertically in an isolated organ bath device. Contractions were measured isometrically with a Narco-Biosystems force displacement transducer (model F-60, Narco-Biosystems, Houston, TX, USA) and recorded on a 4-channel Narco-Biosystems desk model polygraph. Phenylephrine (1 microM) was used to induce tonic contractions in the corpus cavernosum (3-5 g tension) and cavernous artery (0.5-1 g tension) until reaching a plateau. After precontraction, smooth muscle relaxants were used to produce relaxation-response curves (10(-12) M to 10(-4) M). Sodium nitroprusside was used as a relaxation control. The harvesting technique and the smooth muscle contraction-relaxation model described in this study were shown to be useful instruments in the search for new drugs for the treatment of human erectile dysfunction.
Electromyogram amplitude estimation with adaptive smoothing window length.
Clancy, E A
1999-06-01
Typical electromyogram (EMG) amplitude estimators use a fixed window length for smoothing the amplitude estimate. When the EMG amplitude is dynamic, previous research suggests that varying the smoothing length as a function of time may improve amplitude estimation. This paper develops optimal time-varying selection of the smoothing window length using a stochastic model of the EMG signal. Optimal selection is a function of the EMG amplitude and its derivatives. Simulation studies, in which EMG amplitude was changed randomly, found that the "best" adaptive filter performed as well as the "best" fixed-length filter. Experimental studies found the advantages of the adaptive processor to be situation dependent. Subjects used real-time EMG amplitude estimates to track a randomly-moving target. Perhaps due to task difficulty, no differences in adaptive versus fixed-length processors were observed when the target speed was fast. When the target speed was slow, the experimental results were consistent with the simulation predictions. When the target moved between two constant levels, the adaptive processor responded rapidly to the target level transitions and had low variance while the target dwelled on a level.
Genetic susceptibility to environmental toxicants
DEFF Research Database (Denmark)
2001-01-01
The toxicological challenges to the chemical industry have in recent years been greatly affected by the rapid innovation and development of analytical, molecular and genetic technologies. ECETOC recognises the importance of developing the technical and intellectual skill bases in academia...... and industrial based laboratories to meet the rapid development of the science base of toxicology. As the technology to determine genetic susceptibility develops, so scientist will be able to describe altered gene expression provoked by chemicals long before they are able to offer valid interpretations...... of their meaning. A potential for inadvertently raising concerns over the effect of chemicals in experimental animals or man, or even the intentional misrepresentation of results to suggest chemicals are “playing” with our genes is enormous. History has shown that some individuals and groups in society are willing...
[Uterine smooth muscle tumors--determination of clinical behavior and classification].
Gincheva, D; Nikolova, M; Gorchev, G; Tomov, S
2014-01-01
The establishment of the clinical behavior of uterine smooth muscle tumors /USMT/ is an essential stage of modern diagnostics. There are significant differences in the criteria determining the malignant potential of smooth muscle gynecological tumors. Generally USMT generating diagnostic problems are classified into: clinically benign tumors; clinically malignant tumors with benign morphological features; smooth muscle tumors of uncertain malignant potential (SMTUMP) and lesions whose smooth muscle differentiation is not obvious. The knowledge in this area is essential for an adequate therapeutic approach.
Chang, Julia Yu Fong; Kessler, Harvey P.
2008-01-01
Myofibromas are well described in the head and neck region, but differentiating them from smooth muscle lesions is still difficult using smooth muscle immunohistochemical stains. This study evaluated the usefulness of the Masson trichrome stain in differentiating myofibromas from smooth muscle lesions in the head and neck region. Methods: Samples of 11 oral myofibromas, two leiomyomas, one angioleiomyoma, and one smooth muscle hamartoma were retrieved from our archives. Immunohistochemistr...
Accuracy of magnetic resonance based susceptibility measurements
Erdevig, Hannah E.; Russek, Stephen E.; Carnicka, Slavka; Stupic, Karl F.; Keenan, Kathryn E.
2017-05-01
Magnetic Resonance Imaging (MRI) is increasingly used to map the magnetic susceptibility of tissue to identify cerebral microbleeds associated with traumatic brain injury and pathological iron deposits associated with neurodegenerative diseases such as Parkinson's and Alzheimer's disease. Accurate measurements of susceptibility are important for determining oxygen and iron content in blood vessels and brain tissue for use in noninvasive clinical diagnosis and treatment assessments. Induced magnetic fields with amplitude on the order of 100 nT, can be detected using MRI phase images. The induced field distributions can then be inverted to obtain quantitative susceptibility maps. The focus of this research was to determine the accuracy of MRI-based susceptibility measurements using simple phantom geometries and to compare the susceptibility measurements with magnetometry measurements where SI-traceable standards are available. The susceptibilities of paramagnetic salt solutions in cylindrical containers were measured as a function of orientation relative to the static MRI field. The observed induced fields as a function of orientation of the cylinder were in good agreement with simple models. The MRI susceptibility measurements were compared with SQUID magnetometry using NIST-traceable standards. MRI can accurately measure relative magnetic susceptibilities while SQUID magnetometry measures absolute magnetic susceptibility. Given the accuracy of moment measurements of tissue mimicking samples, and the need to look at small differences in tissue properties, the use of existing NIST standard reference materials to calibrate MRI reference structures is problematic and better reference materials are required.
Proteochemometric modeling of HIV protease susceptibility
National Research Council Canada - National Science Library
Lapins, Maris; Eklund, Martin; Spjuth, Ola; Prusis, Peteris; Wikberg, Jarl E S
2008-01-01
.... Therefore, we used proteochemometrics to model the susceptibility of HIV to protease inhibitors in current use, utilizing descriptions of the physico-chemical properties of mutated HIV proteases...
Stein, David B.; Guy, Robert D.; Thomases, Becca
2016-01-01
The Immersed Boundary method is a simple, efficient, and robust numerical scheme for solving PDE in general domains, yet it only achieves first-order spatial accuracy near embedded boundaries. In this paper, we introduce a new high-order numerical method which we call the Immersed Boundary Smooth Extension (IBSE) method. The IBSE method achieves high-order accuracy by smoothly extending the unknown solution of the PDE from a given smooth domain to a larger computational domain, enabling the use of simple Cartesian-grid discretizations (e.g. Fourier spectral methods). The method preserves much of the flexibility and robustness of the original IB method. In particular, it requires minimal geometric information to describe the boundary and relies only on convolution with regularized delta-functions to communicate information between the computational grid and the boundary. We present a fast algorithm for solving elliptic equations, which forms the basis for simple, high-order implicit-time methods for parabolic PDE and implicit-explicit methods for related nonlinear PDE. We apply the IBSE method to solve the Poisson, heat, Burgers', and Fitzhugh-Nagumo equations, and demonstrate fourth-order pointwise convergence for Dirichlet problems and third-order pointwise convergence for Neumann problems.
Pipes, G. C. Teg; Sinha, Sanjay; Qi, Xiaoxia; Zhu, Chun-Hong; Gallardo, Teresa D.; Shelton, John; Creemers, Esther E.; Sutherland, Lillian; Richardson, James A.; Garry, Daniel J.; Wright, Woodring E.; Owens, Gary K.; Olson, Eric N.
2005-01-01
The Serum Response Factor (SRF) coactivator myocardin stimulates the transcription of multiple muscle genes during cardiac and smooth muscle development. Mouse embryos lacking myocardin die during the earliest stages of smooth muscle development and fail to express multiple smooth muscle marker
Woudt, Edwin; de Boer, Pieter-Tjerk; van Ommeren, Jan C.W.
2007-01-01
Previous work on state-dependent adaptive importance sampling techniques for the simulation of rare events in Markovian queueing models used either no smoothing or a parametric smoothing technique, which was known to be non-optimal. In this paper, we introduce the use of kernel smoothing in this
Smoothing of respiratory motion traces for motion-compensated radiotherapy.
Ernst, Floris; Schlaefer, Alexander; Schweikard, Achim
2010-01-01
The CyberKnife system has been used successfully for several years to radiosurgically treat tumors without the need for stereotactic fixation or sedation of the patient. It has been shown that tumor motion in the lung, liver, and pancreas can be tracked with acceptable accuracy and repeatability. However, highly precise targeting for tumors in the lower abdomen, especially for tumors which exhibit strong motion, remains problematic. Reasons for this are manifold, like the slow tracking system operating at 26.5 Hz, and using the signal from the tracking camera "as is." Since the motion recorded with the camera is used to compensate for system latency by prediction and the predicted signal is subsequently used to infer the tumor position from a correlation model based on x-ray imaging of gold fiducials around the tumor, camera noise directly influences the targeting accuracy. The goal of this work is to establish the suitability of a new smoothing method for respiratory motion traces used in motion-compensated radiotherapy. The authors endeavor to show that better prediction--With a lower rms error of the predicted signal--and/or smoother prediction is possible using this method. The authors evaluated six commercially available tracking systems (NDI Aurora, PolarisClassic, Polaris Vicra, MicronTracker2 H40, FP5000, and accuTrack compact). The authors first tracked markers both stationary and while in motion to establish the systems' noise characteristics. Then the authors applied a smoothing method based on the a trous wavelet decomposition to reduce the devices' noise level. Additionally, the smoothed signal of the moving target and a motion trace from actual human respiratory motion were subjected to prediction using the MULIN and the nLMS2 algorithms. The authors established that the noise distribution for a static target is Gaussian and that when the probe is moved such as to mimic human respiration, it remains Gaussian with the exception of the FP5000 and the
Smooth extrapolation of unknown anatomy via statistical shape models
Grupp, R. B.; Chiang, H.; Otake, Y.; Murphy, R. J.; Gordon, C. R.; Armand, M.; Taylor, R. H.
2015-03-01
Several methods to perform extrapolation of unknown anatomy were evaluated. The primary application is to enhance surgical procedures that may use partial medical images or medical images of incomplete anatomy. Le Fort-based, face-jaw-teeth transplant is one such procedure. From CT data of 36 skulls and 21 mandibles separate Statistical Shape Models of the anatomical surfaces were created. Using the Statistical Shape Models, incomplete surfaces were projected to obtain complete surface estimates. The surface estimates exhibit non-zero error in regions where the true surface is known; it is desirable to keep the true surface and seamlessly merge the estimated unknown surface. Existing extrapolation techniques produce non-smooth transitions from the true surface to the estimated surface, resulting in additional error and a less aesthetically pleasing result. The three extrapolation techniques evaluated were: copying and pasting of the surface estimate (non-smooth baseline), a feathering between the patient surface and surface estimate, and an estimate generated via a Thin Plate Spline trained from displacements between the surface estimate and corresponding vertices of the known patient surface. Feathering and Thin Plate Spline approaches both yielded smooth transitions. However, feathering corrupted known vertex values. Leave-one-out analyses were conducted, with 5% to 50% of known anatomy removed from the left-out patient and estimated via the proposed approaches. The Thin Plate Spline approach yielded smaller errors than the other two approaches, with an average vertex error improvement of 1.46 mm and 1.38 mm for the skull and mandible respectively, over the baseline approach.
Neuronal nitric oxide inhibits intestinal smooth muscle growth.
Pelletier, Anne-Marie; Venkataramana, Shriram; Miller, Kurtis G; Bennett, Brian M; Nair, Dileep G; Lourenssen, Sandra; Blennerhassett, Michael G
2010-06-01
Hyperplasia of smooth muscle contributes to the thickening of the intestinal wall that is characteristic of inflammation, but the mechanisms of growth control are unknown. Nitric oxide (NO) from enteric neurons expressing neuronal NO synthase (nNOS) might normally inhibit intestinal smooth muscle cell (ISMC) growth, and this was tested in vitro. In ISMC from the circular smooth muscle of the adult rat colon, chemical NO donors inhibited [(3)H]thymidine uptake in response to FCS, reducing this to baseline without toxicity. This effect was inhibited by the guanylyl cyclase inhibitor ODQ and potentiated by the phosphodiesterase-5 inhibitor zaprinast. Inhibition was mimicked by 8-bromo (8-Br)-cGMP, and ELISA measurements showed increased levels of cGMP but not cAMP in response to sodium nitroprusside. However, 8-Br-cAMP and cilostamide also showed inhibitory actions, suggesting an additional role for cAMP. Via a coculture model of ISMC and myenteric neurons, immunocytochemistry and image analysis showed that innervation reduced bromodeoxyuridine uptake by ISMC. Specific blockers of nNOS (7-NI, NAAN) significantly increased [(3)H]thymidine uptake in response to a standard stimulus, showing that nNOS activity normally inhibits ISMC growth. In vivo, nNOS axon number was reduced threefold by day 1 of trinitrobenzene sulfonic acid-induced rat colitis, preceding the hyperplasia of ISMC described earlier in this model. We conclude that NO can inhibit ISMC growth primarily via a cGMP-dependent mechanism. Functional evidence that NO derived from nNOS causes inhibition of ISMC growth in vitro predicts that the loss of nNOS expression in colitis contributes to ISMC hyperplasia in vivo.
Effects of slope smoothing in river channel modeling
Kim, Kyungmin; Liu, Frank; Hodges, Ben R.
2017-04-01
In extending dynamic river modeling with the 1D Saint-Venant equations from a single reach to a large watershed there are critical questions as to how much bathymetric knowledge is necessary and how it should be represented parsimoniously. The ideal model will include the detail necessary to provide realism, but not include extraneous detail that should not exert a control on a 1D (cross-section averaged) solution. In a Saint-Venant model, the overall complexity of the river channel morphometry is typically abstracted into metrics for the channel slope, cross-sectional area, hydraulic radius, and roughness. In stream segments where cross-section surveys are closely spaced, it is not uncommon to have sharp changes in slope or even negative values (where a positive slope is the downstream direction). However, solving river flow with the Saint-Venant equations requires a degree of smoothness in the equation parameters or the equation set with the directly measured channel slopes may not be Lipschitz continuous. The results of non-smoothness are typically extended computational time to converge solutions (or complete failure to converge) and/or numerical instabilities under transient conditions. We have investigated using cubic splines to smooth the bottom slope and ensure always positive reference slopes within a 1D model. This method has been implemented in the Simulation Program for River Networks (SPRNT) and is compared to the standard HEC-RAS river solver. It is shown that the reformulation of the reference slope is both in keeping with the underlying derivation of the Saint-Venant equations and provides practical numerical stability without altering the realism of the simulation. This research was supported in part by the National Science Foundation under grant number CCF-1331610.
Bessel smoothing filter for spectral-element mesh
Trinh, P. T.; Brossier, R.; Métivier, L.; Virieux, J.; Wellington, P.
2017-06-01
Smoothing filters are extremely important tools in seismic imaging and inversion, such as for traveltime tomography, migration and waveform inversion. For efficiency, and as they can be used a number of times during inversion, it is important that these filters can easily incorporate prior information on the geological structure of the investigated medium, through variable coherent lengths and orientation. In this study, we promote the use of the Bessel filter to achieve these purposes. Instead of considering the direct application of the filter, we demonstrate that we can rely on the equation associated with its inverse filter, which amounts to the solution of an elliptic partial differential equation. This enhances the efficiency of the filter application, and also its flexibility. We apply this strategy within a spectral-element-based elastic full waveform inversion framework. Taking advantage of this formulation, we apply the Bessel filter by solving the associated partial differential equation directly on the spectral-element mesh through the standard weak formulation. This avoids cumbersome projection operators between the spectral-element mesh and a regular Cartesian grid, or expensive explicit windowed convolution on the finite-element mesh, which is often used for applying smoothing operators. The associated linear system is solved efficiently through a parallel conjugate gradient algorithm, in which the matrix vector product is factorized and highly optimized with vectorized computation. Significant scaling behaviour is obtained when comparing this strategy with the explicit convolution method. The theoretical numerical complexity of this approach increases linearly with the coherent length, whereas a sublinear relationship is observed practically. Numerical illustrations are provided here for schematic examples, and for a more realistic elastic full waveform inversion gradient smoothing on the SEAM II benchmark model. These examples illustrate well the
Experimental comparison of PV-smoothing controllers using distributed generators
Energy Technology Data Exchange (ETDEWEB)
Johnson, Jay Dean; Ellis, Abraham; Denda, Atsushi; Morino, Kimio; Hawkins, John N.; Arellano, Brian; Shinji, Takao; Ogata, Takao; Tadokoro, Masayuki
2014-02-01
The power output variability of photovoltaic systems can affect local electrical grids in locations with high renewable energy penetrations or weak distribution or transmission systems. In those rare cases, quick controllable generators (e.g., energy storage systems) or loads can counteract the destabilizing effects by compensating for the power fluctuations. Previously, control algorithms for coordinated and uncoordinated operation of a small natural gas engine-generator (genset) and a battery for smoothing PV plant output were optimized using MATLAB/Simulink simulations. The simulations demonstrated that a traditional generation resource such as a natural gas genset in combination with a battery would smooth the photovoltaic output while using a smaller battery state of charge (SOC) range and extending the life of the battery. This paper reports on the experimental implementation of the coordinated and uncoordinated controllers to verify the simulations and determine the differences in the controllers. The experiments were performed with the PNM PV and energy storage Prosperity site and a gas engine-generator located at the Aperture Center at Mesa Del Sol in Albuquerque, New Mexico. Two field demonstrations were performed to compare the different PV smoothing control algorithms: (1) implementing the coordinated and uncoordinated controls while switching off a subsection of the PV array at precise times on successive clear days, and (2) comparing the results of the battery and genset outputs for the coordinated control on a high variability day with simulations of the coordinated and uncoordinated controls. It was found that for certain PV power profiles the SOC range of the battery may be larger with the coordinated control, but the total amp-hours through the battery-which approximates battery wear-will always be smaller with the coordinated control.
Interaction of Vascular Smooth Muscle Cells Under Low Shear Stress
Seidel, Charles L.
1998-01-01
The blood vessel wall consists of three cellular layers, an outer adventitial, a middle medial and an inner intimal layer. When the blood vessel forms in the embryo it begins as a tube composed of a single cell type called endothelial cells. Over time, other cells are recruited from the surrounding tissue to form additional layers on the outer surface of the endothelial tube. The cells that are recruited are called mesenchymal cells. Mesenchymal cells are responsible for the production of connective tissue that holds the blood vessel together and for developing into vascular smooth muscle cells that are responsible for regulating the diameter of the vessel (1) and therefore, blood flow. In a fully developed blood vessel, the endothelial cells make- up the majority of cells in the intimal layer while the mesenchymal cells make-up the majority of cells in the medial and adventitial layers. Within the medial layer of a mature vessel, cells are organized into multiple circular layers of alternating bands of connective tissue and cells. The cell layer is composed of a mixture of mesenchymal cells that have not developed into smooth muscle cells and fully developed smooth muscle cells (2). The assembly and organization of complex tissues is directed in part by a signaling system composed of proteins on the cell surface called adhesion molecules. Adhesion molecules enable cells to recognize each other as well as the composition of the connective tissue in which they reside (3). It was hypothesized that the different cell types that compose the vascular wall possess different adhesion molecules that enable them to recognize each other and through this recognition system, form the complex layered organization of the vascular wall. In other words, the layered organization is an intrinsic property of the cells. If this hypothesis is correct then the different cells that make up the vessel wall, when mixed together, should organize themselves into a layered structure
Search for new breast cancer susceptibility genes
Oldenburg, Rogier Abel
2008-01-01
This thesis describes the search for new high-risk breast cancer susceptibility genes by linkage analysis. To date 20-25% of familial breast cancer is explained by mutations in the high-risk BRCA1 and BRCA2 breast cancer susceptibility genes. For the remaining families the genetic etiology is
Mapping markers linked to porcine salmonellosis susceptibility
Galina-Pantoja, L.; Siggens, K.; Schriek, van M.G.M.; Heuven, H.C.M.
2009-01-01
The goal of this study was to identify pig chromosomal regions associated with susceptibility to salmonellosis. Genomic DNA from pig reference populations with differences in susceptibility to Salmonella enterica serovar Choleraesuis as quantified by spleen and liver bacterial colonization at day 7
Crystal morphology change by magnetic susceptibility force
Katsuki, Aiko; Aibara, Shigeo; Tanimoto, Yoshifumi
2006-01-01
We found a change in morphology when lysozyme crystals were grown in a magnetic field. The phenomenon was caused by the magnetic force derived from the magnetic susceptibility gradient. We propose that this force should be called the “magnetic susceptibility force".
Modeling electrokinetic flows by consistent implicit incompressible smoothed particle hydrodynamics
Pan, Wenxiao; Kim, Kyungjoo; Perego, Mauro; Tartakovsky, Alexandre M.; Parks, Michael L.
2017-04-01
We present a consistent implicit incompressible smoothed particle hydrodynamics (I2SPH) discretization of Navier-Stokes, Poisson-Boltzmann, and advection-diffusion equations subject to Dirichlet or Robin boundary conditions. It is applied to model various two and three dimensional electrokinetic flows in simple or complex geometries. The accuracy and convergence of the consistent I2SPH are examined via comparison with analytical solutions, grid-based numerical solutions, or empirical models. The new method provides a framework to explore broader applications of SPH in microfluidics and complex fluids with charged objects, such as colloids and biomolecules, in arbitrary complex geometries.
Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage
DEFF Research Database (Denmark)
Edvinsson, Lars; Larsen, Stine Schmidt; Maddahi, Aida
2014-01-01
Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression......, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature...
Brownian semi-stationary processes, turbulence and smooth processes
DEFF Research Database (Denmark)
Urbina, José Ulises Márquez
This thesis analysis the use of Brownian semi-stationary (BSS) processes to model the main statistical features present in turbulent time series, and some asymptotic properties of certain classes of smooth processes. Turbulence is a complex phenomena governed by the Navier-Stokes equations....... We also studied the distributional properties of the increments of BSS processes with the intent to better understand why the BSS processes seem to accurately reproduce the temporal turbulent dynamics. BSS processes in general are not semimartingales. However, there are conditions which make a BSS...
Modeling electrokinetic flows by consistent implicit incompressible smoothed particle hydrodynamics
Energy Technology Data Exchange (ETDEWEB)
Pan, Wenxiao; Kim, Kyungjoo; Perego, Mauro; Tartakovsky, Alexandre M.; Parks, Michael L.
2017-04-01
We present an efficient implicit incompressible smoothed particle hydrodynamics (I2SPH) discretization of Navier-Stokes, Poisson-Boltzmann, and advection-diffusion equations subject to Dirichlet or Robin boundary conditions. It is applied to model various two and three dimensional electrokinetic flows in simple or complex geometries. The I2SPH's accuracy and convergence are examined via comparison with analytical solutions, grid-based numerical solutions, or empirical models. The new method provides a framework to explore broader applications of SPH in microfluidics and complex fluids with charged objects, such as colloids and biomolecules, in arbitrary complex geometries.
A Smoothed Eclipse Model for Solar Electric Propulsion Trajectory Optimization
Aziz, Jonathan; Scheeres, Daniel; Parker, Jeffrey; Englander, Jacob
2017-01-01
Solar electric propulsion (SEP) is the dominant design option for employing low-thrust propulsion on a space mission. Spacecraft solar arrays power the SEP system but are subject to blackout periods during solar eclipse conditions. Discontinuity in power available to the spacecraft must be accounted for in trajectory optimization, but gradient-based methods require a differentiable power model. This work presents a power model that smooths the eclipse transition from total eclipse to total sunlight with a logistic function. Example trajectories are computed with differential dynamic programming, a second-order gradient-based method.
Smooth bridge between guided waves and spoof surface plasmon polaritons.
Liu, Liangliang; Li, Zhuo; Gu, Changqing; Xu, Bingzheng; Ning, Pingping; Chen, Chen; Yan, Jian; Niu, Zhenyi; Zhao, Yongjiu
2015-04-15
In this work, we build a smooth bridge between a coaxial waveguide and a plasmonic waveguide with subwavelength periodically cylindrical radial grooves, to realize high-efficiency mode conversion between conventional guided waves and spoof surface plasmon polaritons in broadband. This bridge consists of a flaring coaxial waveguide connected with a metal cylindrical wire corrugated with subwavelength gradient radial grooves. Experimental results of the transmission and reflection coefficients show excellent agreement with the numerical simulations. The proposed scheme can be extended readily to other bands and the bridge structure can find potential applications in the integration of conventional microwave or terahertz devices with plasmonic circuits.
A numerical optimization approach to generate smoothing spherical splines
Machado, L.; Monteiro, M. Teresa T.
2017-01-01
Approximating data in curved spaces is a common procedure that is extremely required by modern applications arising, for instance, in aerospace and robotics industries. Here, we are particularly interested in finding smoothing cubic splines that best fit given data in the Euclidean sphere. To achieve this aim, a least squares optimization problem based on the minimization of a certain cost functional is formulated. To solve the problem a numerical algorithm is implemented using several routines from MATLAB toolboxes. The proposed algorithm is shown to be easy to implement, very accurate and precise for spherical data chosen randomly.
Electric drive systems including smoothing capacitor cooling devices and systems
Dede, Ercan Mehmet; Zhou, Feng
2017-02-28
An electric drive system includes a smoothing capacitor including at least one terminal, a bus bar electrically coupled to the at least one terminal, a thermoelectric device including a first side and a second side positioned opposite the first side, where the first side is thermally coupled to at least one of the at least one terminal and the bus bar, and a cooling element thermally coupled to the second side of the thermoelectric device, where the cooling element dissipates heat from the thermoelectric device.
Violation of smooth observable macroscopic realism in a harmonic oscillator.
Leshem, Amir; Gat, Omri
2009-08-14
We study the emergence of macrorealism in a harmonic oscillator subject to consecutive measurements of a squeezed action. We demonstrate a breakdown of dynamical realism in a wide parameter range that is maximized in a scaling limit of extreme squeezing, where it is based on measurements of smooth observables, implying that macroscopic realism is not valid in the harmonic oscillator. We propose an indirect experimental test of these predictions with entangled photons by demonstrating that local realism in a composite system implies dynamical realism in a subsystem.
Smoothed Particle Hydrodynamics Method for Two-dimensional Stefan Problem
Tarwidi, Dede
2016-01-01
Smoothed particle hydrodynamics (SPH) is developed for modelling of melting and solidification. Enthalpy method is used to solve heat conduction equations which involved moving interface between phases. At first, we study the melting of floating ice in the water for two-dimensional system. The ice objects are assumed as solid particles floating in fluid particles. The fluid and solid motion are governed by Navier-Stokes equation and basic rigid dynamics equation, respectively. We also propose a strategy to separate solid particles due to melting and solidification. Numerical results are obtained and plotted for several initial conditions.
On the Complexity of Smooth Projective Toric Varieties
Hosten, S
1996-01-01
In this paper we answer a question posed by V.V. Batyrev. The question asked if there exists a complete regular fan with more than quadratically many primitive collections. We construct a smooth projective toric variety associated to a complete regular fan $\\Delta$ in R^d with $n$ generators where the number of primitive collections of $\\Delta$ is at least exponential in $n-d$. We also exhibit the connection between the number of primitive collections of $\\Delta$ and the facet complexity of the Gröbner fan of the associated integer program.
Dual conformal transformations of smooth holographic Wilson loops
Energy Technology Data Exchange (ETDEWEB)
Dekel, Amit [Nordita, KTH Royal Institute of Technology and Stockholm University, Roslagstullsbacken 23, SE-106 91 Stockholm (Sweden)
2017-01-19
We study dual conformal transformations of minimal area surfaces in AdS{sub 5}×S{sup 5} corresponding to holographic smooth Wilson loops and some other related observables. To act with dual conformal transformations we map the string solutions to the dual space by means of T-duality, then we apply a conformal transformation and finally T-dualize back to the original space. The transformation maps between string solutions with different boundary contours. The boundary contours of the minimal surfaces are not mapped back to the AdS boundary, and the regularized area of the surface changes.
Ferguson curve model and morphological smoothing of ruled surfaces
Popov, Antony T.
2001-11-01
This work studies the generation of a ruled surface from scattered data, which can be obtained by a shape- from - X procedure or can be an experimental output. The ruled surface is generated by the so- called Ferguson Curve Model. This model is an interpolation technique based on parametric cubic polynomials, and thus guaranteeing continuity of the curvature in each point of the initial set. We show how morphological operations - esp. openings and closings can be used to obtain good smoothness of the surface in practice. An application to robot motion planning is presented.
Measurements of drag and lift on smooth balls in flight
Cross, Rod; Lindsey, Crawford
2017-07-01
Measurements are presented on the drag and lift coefficients for three relatively smooth balls launched in air and tracked with two cameras separated horizontally by 6.4 m. The ball spin was varied in order to investigate whether the Magnus force would increase or decrease when the ball spin was increased. For one ball, the Magnus force increased. For another ball, the Magnus force decreased almost to zero after reaching a maximum. For the third ball, the Magnus force was negative at low ball spins and positive at high ball spins. For one of the balls, the ball spin increased with time as it travelled through the air.
On the vanishing rate of smooth CR functions
Directory of Open Access Journals (Sweden)
Giuseppe Della Sala
2014-01-01
Full Text Available Let be a lineally convex hypersurface of ℂⁿ of finite type, 0∈. Then there exist non-trivial smooth CR functions on that are flat at 0, i.e. whose Taylor expansion about 0 vanishes identically. Our aim is to characterize the rate at which flat CR functions can decrease without vanishing identically. As it turns out, non-trivial CR functions cannot decay arbitrarily fast, and a possible way of expressing the critical rate is by comparison with a suitable exponential of the modulus of a local peak function.
A Method for Low-Delay Pitch Tracking and Smoothing
Christensen, Mads Græsbøll
2012-01-01
In this paper, a new method for pitch tracking is presented. The method is comprised of two steps. In the first step, accurate pitch estimates are obtained on a sample-by-sample basis by updates of the signal statistics with an exponential forgetting factor and subse- quent numerical optimization. In the second step, a Kalman filter is used to smooth the estimates and separate the pitch into a slowly varying component and a rapidly varying component. The former represents the mean pitch while...
Genetic susceptibility to pancreatic cancer.
Klein, Alison P
2012-01-01
Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States. However, it has the poorest prognosis of any major tumor type, with a 5-yr survival rate of approximately 5%. Cigarette smoking, increased body mass index, heavy alcohol consumption, and a diagnosis of diabetes mellitus have all been demonstrated to increase risk of pancreatic cancer. A family history of pancreatic cancer has also been associated with increased risk suggesting inherited genetic factors also play an important role, with approximately 5-10% of pancreatic cancer patients reporting family history of pancreatic cancer. While the genetic basis for the majority of the familial clustering of pancreatic cancer remains unclear, several important pancreatic cancer genes have been identified. These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus. Recent advances in genotyping and genetic sequencing have accelerated the rate at which novel pancreatic cancer susceptibility genes have been identified with several genes identified within the past few years. This review addresses our current understanding of the familial aggregation of pancreatic cancer, established pancreatic cancer susceptablity genes and how this knowledge informs risk assessment and screening for high-risk families. Copyright © 2011 Wiley Periodicals, Inc.
Genetic Susceptibility to Pancreatic Cancer
Klein, Alison P.
2013-01-01
Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States. However, it has the poorest prognosis of any major tumor type, with a 5-yr survival rate of approximately 5%. Cigarette smoking, increased body mass index, heavy alcohol consumption, and a diagnosis of diabetes mellitus have all been demonstrated to increase risk of pancreatic cancer. A family history of pancreatic cancer has also been associated with increased risk suggesting inherited genetic factors also play an important role, with approximately 5–10% of pancreatic cancer patients reporting family history of pancreatic cancer. While the genetic basis for the majority of the familial clustering of pancreatic cancer remains unclear, several important pancreatic cancer genes have been identified. These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus. Recent advances in genotyping and genetic sequencing have accelerated the rate at which novel pancreatic cancer susceptibility genes have been identified with several genes identified within the past few years. This review addresses our current understanding of the familial aggregation of pancreatic cancer, established pancreatic cancer susceptablity genes and how this knowledge informs risk assessment and screening for high-risk families. PMID:22162228
DEFF Research Database (Denmark)
Rumessen, Jüri Johannes; Thuneberg, Lars
1991-01-01
Anatomy, interstitial cells of Cajal, small intestine, gut motility, pacemaker cells, smooth muscle......Anatomy, interstitial cells of Cajal, small intestine, gut motility, pacemaker cells, smooth muscle...
Chang, Julia Yu Fong; Kessler, Harvey P
2008-10-01
Myofibromas are well described in the head and neck region, but differentiating them from smooth muscle lesions is still difficult using smooth muscle immunohistochemical stains. This study evaluated the usefulness of the Masson trichrome stain in differentiating myofibromas from smooth muscle lesions in the head and neck region. Samples of 11 oral myofibromas, two leiomyomas, one angioleiomyoma, and one smooth muscle hamartoma were retrieved from our archives. Immunohistochemistry and Masson trichrome stains were performed on tissue sections of these lesions. All 11 oral myofibromas, seven from male patients and four from female patients, were solitary myofibromas. The patients' mean age at diagnosis was 32.8 years. Oral myofibromas occurred most commonly on the gingiva (four cases) and in the mandible (three cases). With the Masson trichrome stain, the smooth muscle cell cytoplasm was stained red, while the collagenous fibrous tissue was stained blue. Myofibromas and smooth muscle lesions demonstrated different characteristic patterns with the Masson trichrome stain. Myofibromas were composed of a much more collagenous stroma intermixed with the spindle cells. Thick fibrous bundles with random, irregularly intersecting angles were prominent in myofibromas. Smooth muscle lesions showed only minimal delicate fibrous tissue surrounding the smooth muscle cells and in the septa between the smooth muscle masses. On low-power view, red masses of smooth muscle tumor surrounded by blue fibrous tissue were observed. The Masson trichrome stain can be a useful tool to differentiate myofibromas from smooth muscle lesions, but immunohistochemical methods to rule out other spindle cell lesions are still needed.
The Jacobian Consistency of a One-Parametric Class of Smoothing Functions for SOCCP
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Xiaoni Chi
2013-01-01
Full Text Available Second-order cone (SOC complementarity functions and their smoothing functions have been much studied in the solution of second-order cone complementarity problems (SOCCP. In this paper, we study the directional derivative and B-subdifferential of the one-parametric class of SOC complementarity functions, propose its smoothing function, and derive the computable formula for the Jacobian of the smoothing function. Based on these results, we prove the Jacobian consistency of the one-parametric class of smoothing functions, which will play an important role for achieving the rapid convergence of smoothing methods. Moreover, we estimate the distance between the subgradient of the one-parametric class of the SOC complementarity functions and the gradient of its smoothing function, which will help to adjust a parameter appropriately in smoothing methods.
Fidelity susceptibility in the quantum Rabi model
Wei, Bo-Bo; Lv, Xiao-Chen
2018-01-01
Quantum criticality usually occurs in many-body systems. Recently it was shown that the quantum Rabi model, which describes a two-level atom coupled to a single model cavity field, presents quantum phase transitions from a normal phase to a superradiate phase when the ratio between the frequency of the two-level atom and the frequency of the cavity field extends to infinity. In this work, we study quantum phase transitions in the quantum Rabi model from the fidelity susceptibility perspective. We found that the fidelity susceptibility and the generalized adiabatic susceptibility present universal finite-size scaling behaviors near the quantum critical point of the Rabi model if the ratio between frequency of the two-level atom and frequency of the cavity field is finite. From the finite-size scaling analysis of the fidelity susceptibility, we found that the adiabatic dimension of the fidelity susceptibility and the generalized adiabatic susceptibility of fourth order in the Rabi model are 4 /3 and 2, respectively. Meanwhile, the correlation length critical exponent and the dynamical critical exponent in the quantum critical point of the Rabi model are found to be 3 /2 and 1 /3 , respectively. Since the fidelity susceptibility and the generalized adiabatic susceptibility are the moments of the quantum noise spectrum which are directly measurable by experiments in linear response regime, the scaling behavior of the fidelity susceptibility in the Rabi model could be tested experimentally. The simple structure of the quantum Rabi model paves the way for experimentally observing the universal scaling behavior of the fidelity susceptibility at a quantum phase transition.
Quantitative assessment of susceptibility weighted imaging processing methods
Li, Ningzhi; Wang, Wen-Tung; Sati, Pascal; Pham, Dzung L.; Butman, John A.
2013-01-01
Purpose To evaluate different susceptibility weighted imaging (SWI) phase processing methods and parameter selection, thereby improving understanding of potential artifacts, as well as facilitating choice of methodology in clinical settings. Materials and Methods Two major phase processing methods, Homodyne-filtering and phase unwrapping-high pass (HP) filtering, were investigated with various phase unwrapping approaches, filter sizes, and filter types. Magnitude and phase images were acquired from a healthy subject and brain injury patients on a 3T clinical Siemens MRI system. Results were evaluated based on image contrast to noise ratio and presence of processing artifacts. Results When using a relatively small filter size (32 pixels for the matrix size 512 × 512 pixels), all Homodyne-filtering methods were subject to phase errors leading to 2% to 3% masked brain area in lower and middle axial slices. All phase unwrapping-filtering/smoothing approaches demonstrated fewer phase errors and artifacts compared to the Homodyne-filtering approaches. For performing phase unwrapping, Fourier-based methods, although less accurate, were 2–4 orders of magnitude faster than the PRELUDE, Goldstein and Quality-guide methods. Conclusion Although Homodyne-filtering approaches are faster and more straightforward, phase unwrapping followed by HP filtering approaches perform more accurately in a wider variety of acquisition scenarios. PMID:24923594
Directory of Open Access Journals (Sweden)
Nguyen Manh Hung
2008-03-01
Full Text Available In this paper, we consider the second initial boundary value problem for strongly general Schrodinger systems in both the finite and the infinite cylinders $Q_T, 0
Directional bilateral filters for smoothing fluorescence microscopy images
Venkatesh, Manasij; Mohan, Kavya; Seelamantula, Chandra Sekhar
2015-08-01
Images obtained through fluorescence microscopy at low numerical aperture (NA) are noisy and have poor resolution. Images of specimens such as F-actin filaments obtained using confocal or widefield fluorescence microscopes contain directional information and it is important that an image smoothing or filtering technique preserve the directionality. F-actin filaments are widely studied in pathology because the abnormalities in actin dynamics play a key role in diagnosis of cancer, cardiac diseases, vascular diseases, myofibrillar myopathies, neurological disorders, etc. We develop the directional bilateral filter as a means of filtering out the noise in the image without significantly altering the directionality of the F-actin filaments. The bilateral filter is anisotropic to start with, but we add an additional degree of anisotropy by employing an oriented domain kernel for smoothing. The orientation is locally adapted using a structure tensor and the parameters of the bilateral filter are optimized for within the framework of statistical risk minimization. We show that the directional bilateral filter has better denoising performance than the traditional Gaussian bilateral filter and other denoising techniques such as SURE-LET, non-local means, and guided image filtering at various noise levels in terms of peak signal-to-noise ratio (PSNR). We also show quantitative improvements in low NA images of F-actin filaments.
Smoothing-Based Relative Navigation and Coded Aperture Imaging
Saenz-Otero, Alvar; Liebe, Carl Christian; Hunter, Roger C.; Baker, Christopher
2017-01-01
This project will develop an efficient smoothing software for incremental estimation of the relative poses and velocities between multiple, small spacecraft in a formation, and a small, long range depth sensor based on coded aperture imaging that is capable of identifying other spacecraft in the formation. The smoothing algorithm will obtain the maximum a posteriori estimate of the relative poses between the spacecraft by using all available sensor information in the spacecraft formation.This algorithm will be portable between different satellite platforms that possess different sensor suites and computational capabilities, and will be adaptable in the case that one or more satellites in the formation become inoperable. It will obtain a solution that will approach an exact solution, as opposed to one with linearization approximation that is typical of filtering algorithms. Thus, the algorithms developed and demonstrated as part of this program will enhance the applicability of small spacecraft to multi-platform operations, such as precisely aligned constellations and fractionated satellite systems.
Effects of lubiprostone on human uterine smooth muscle cells.
Cuppoletti, John; Malinowska, Danuta H; Chakrabarti, Jayati; Ueno, Ryuji
2008-06-01
Lubiprostone, a bicyclic fatty acid derivative and member of a new class of compounds called prostones, locally activates ClC-2 Cl(-) channels without activation of prostaglandin receptors. The present study was specifically designed to test and compare lubiprostone and prostaglandin effects at the cellular level using human uterine smooth muscle cells. Effects on [Ca(2+)](i), membrane potential and [cAMP](i) in human uterine smooth muscle cells were measured. 10 nM lubiprostone significantly decreased [Ca(2+)](i) from 188 to 27 nM, which was unaffected by 100 nM SC-51322, a prostaglandin EP receptor antagonist. In contrast 10nM PGE(2) and PGE(1) both increased [Ca(2+)](i) 3-5-fold which was blocked by SC-51322. Similarly, lubiprostone and prostaglandins had opposite/different effects on membrane potential and [cAMP](i). Lubiprostone caused SC-51322-insensitive membrane hyperpolarization and no effect on [cAMP](i). PGE(2) and PGE(1) both caused SC-51322-sensitive membrane depolarization and increased [cAMP](i). Lubiprostone has fundamentally different cellular effects from prostaglandins that are not mediated by EP receptors.
Smooth time-dependent receiver operating characteristic curve estimators.
Martínez-Camblor, Pablo; Pardo-Fernández, Juan Carlos
2017-01-01
The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, two main extensions have been proposed: the cumulative/dynamic receiver operating characteristic curve and the incident/dynamic receiver operating characteristic curve. In both cases, the main problem for developing appropriate estimators is the estimation of the joint distribution of the variables time-to-event and marker. As usual, different approximations lead to different estimators. In this article, the authors explore the use of a bivariate kernel density estimator which accounts for censored observations in the sample and produces smooth estimators of the time-dependent receiver operating characteristic curves. The performance of the resulting cumulative/dynamic and incident/dynamic receiver operating characteristic curves is studied by means of Monte Carlo simulations. Additionally, the influence of the choice of the required smoothing parameters is explored. Finally, two real-applications are considered. An R package is also provided as a complement to this article.
Smooth Approximation of Lipschitz Functions on Finsler Manifolds
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M. I. Garrido
2013-01-01
Full Text Available We study the smooth approximation of Lipschitz functions on Finsler manifolds, keeping control on the corresponding Lipschitz constants. We prove that, given a Lipschitz function f:M→ℝ defined on a connected, second countable Finsler manifold M, for each positive continuous function ε:M→(0,∞ and each r>0, there exists a C1-smooth Lipschitz function g:M→ℝ such that |f(x-g(x|≤ε(x, for every x∈M, and Lip(g≤Lip(f+r. As a consequence, we derive a completeness criterium in the class of what we call quasi-reversible Finsler manifolds. Finally, considering the normed algebra Cb1(M of all C1 functions with bounded derivative on a complete quasi-reversible Finsler manifold M, we obtain a characterization of algebra isomorphisms T:Cb1(N→Cb1(M as composition operators. From this we obtain a variant of Myers-Nakai Theorem in the context of complete reversible Finsler manifolds.
Contextual effects on smooth-pursuit eye movements.
Spering, Miriam; Gegenfurtner, Karl R
2007-02-01
Segregating a moving object from its visual context is particularly relevant for the control of smooth-pursuit eye movements. We examined the interaction between a moving object and a stationary or moving visual context to determine the role of the context motion signal in driving pursuit. Eye movements were recorded from human observers to a medium-contrast Gaussian dot that moved horizontally at constant velocity. A peripheral context consisted of two vertically oriented sinusoidal gratings, one above and one below the stimulus trajectory, that were either stationary or drifted into the same or opposite direction as that of the target at different velocities. We found that a stationary context impaired pursuit acceleration and velocity and prolonged pursuit latency. A drifting context enhanced pursuit performance, irrespective of its motion direction. This effect was modulated by context contrast and orientation. When a context was briefly perturbed to move faster or slower eye velocity changed accordingly, but only when the context was drifting along with the target. Perturbing a context into the direction orthogonal to target motion evoked a deviation of the eye opposite to the perturbation direction. We therefore provide evidence for the use of absolute and relative motion cues, or motion assimilation and motion contrast, for the control of smooth-pursuit eye movements.
On Smooth Time-Dependent Orbifolds and Null Singularities
Energy Technology Data Exchange (ETDEWEB)
Fabinger, Michel
2002-08-08
We study string theory on a non-singular time-dependent orbifold of flat space. The orbifold group, which involves only space-like identifications, is obtained by a combined action of a null Lorentz transformation and a constant shift in an extra direction. In the limit where the shift goes to zero, the geometry of this orbifold reproduces an orbifold with a light-like singularity, which was recently studied by Liu, Moore and Seiberg (hep-th/0204168). We find that the backreaction on the geometry due to a test particle can be made arbitrarily small, and that there are scattering processes which can be studied in the approximation of a constant background. We quantize strings on this orbifold and calculate the torus partition function. We construct a basis of states on the smooth orbifold whose tree level string interactions are nonsingular. We discuss the existence of physical modes in the singular orbifold which resolve the singularity. We also describe another way of making the singular orbifold smooth which involves a sandwich pp-wave.
ANALYSIS ON CENSORED QUANTILE RESIDUAL LIFE MODEL VIA SPLINE SMOOTHING.
Ma, Yanyuan; Wei, Ying
2012-01-01
We propose a general class of quantile residual life models, where a specific quantile of the residual life time, conditional on an individual has survived up to time t, is a function of certain covariates with their coefficients varying over time. The varying coefficients are assumed to be smooth unspecified functions of t. We propose to estimate the coefficient functions using spline approximation. Incorporating the spline representation directly into a set of unbiased estimating equations, we obtain a one-step estimation procedure, and we show that this leads to a uniformly consistent estimator. To obtain further computational simplification, we propose a two-step estimation approach in which we estimate the coefficients on a series of time points first, and follow this with spline smoothing. We compare the two methods in terms of their asymptotic efficiency and computational complexity. We further develop inference tools to test the significance of the covariate effect on residual life. The finite sample performance of the estimation and testing procedures are further illustrated through numerical experiments. We also apply the methods to a data set from a neurological study.
Response properties of MST parafoveal neurons during smooth pursuit adaptation.
Ono, Seiji; Mustari, Michael J
2016-07-01
Visual motion neurons in the posterior parietal cortex play a critical role in the guidance of smooth pursuit eye movements. Initial pursuit (open-loop period) is driven, in part, by visual motion signals from cortical areas, such as the medial superior temporal area (MST). The purpose of this study was to determine whether adaptation of initial pursuit gain arises because of altered visual sensitivity of neurons at the cortical level. It is well known that the visual motion response in MST is suppressed after exposure to a large-field visual motion stimulus, showing visual motion adaptation. One hypothesis is that foveal motion responses in MST are associated with smooth pursuit adaptation using a small target spot. We used a step-ramp tracking task with two steps of target velocity (double-step paradigm), which induces gain-down or gain-up adaptation. We found that after gain-down adaptation 58% of our MST visual neurons showed a significant decrease in firing rate. This was the case even though visual motion input (before the pursuit onset) from target motion was constant. Therefore, repetitive visual stimulation during the gain-down paradigm could lead to adaptive changes in the visual response. However, the time course of adaptation did not show a correlation between the visual response and pursuit behavior. These results indicate that the visual response in MST may not directly contribute to the adaptive change in pursuit initiation. Copyright © 2016 the American Physiological Society.
Assessing a 3D smoothed seismicity model of induced earthquakes
Zechar, Jeremy; Király, Eszter; Gischig, Valentin; Wiemer, Stefan
2016-04-01
As more energy exploration and extraction efforts cause earthquakes, it becomes increasingly important to control induced seismicity. Risk management schemes must be improved and should ultimately be based on near-real-time forecasting systems. With this goal in mind, we propose a test bench to evaluate models of induced seismicity based on metrics developed by the CSEP community. To illustrate the test bench, we consider a model based on the so-called seismogenic index and a rate decay; to produce three-dimensional forecasts, we smooth past earthquakes in space and time. We explore four variants of this model using the Basel 2006 and Soultz-sous-Forêts 2004 datasets to make short-term forecasts, test their consistency, and rank the model variants. Our results suggest that such a smoothed seismicity model is useful for forecasting induced seismicity within three days, and giving more weight to recent events improves forecast performance. Moreover, the location of the largest induced earthquake is forecast well by this model. Despite the good spatial performance, the model does not estimate the seismicity rate well: it frequently overestimates during stimulation and during the early post-stimulation period, and it systematically underestimates around shut-in. In this presentation, we also describe a robust estimate of information gain, a modification that can also benefit forecast experiments involving tectonic earthquakes.
Ultrafine and Smooth Full Metal Nanostructures for Plasmonics
Zhu, Xinli; Zhang, Jaseng; Xu, Jun; Liao, Zhimin; Wu, Xiaosong; Yu, Dapeng
2013-03-01
Surface plasmon polaritons (SPPs), which are coupled excitations of electrons bound to a metal-dielectric interface, show great potential for application in future nanoscale photonic systems due to the strong field confinement at the nanoscale, intensive local field enhancement, and interplay between strongly localized and propagating SPPs. The fabrication of sufficiently smooth metal surface with nanoscale feature size is crucial for SPPs to have practical applications. A template stripping (ST) method combined with PMMA as a template was successfully developed to create extraordinarily smooth metal nanostructures with a desirable feature size and morphology for plasmonics and metamaterials. The advantages of this method, including the high resolution, precipitous top-to bottom profile with a high aspect ratio, and three-dimensional characteristics, make it very suitable for the fabrication of plasmonic structures. By using this ST method, boxing ring-shaped nanocavities have been fabricated and the confined modes of surface plasmon polaritons in these nanocavities have been investigated and imaged by using cathodoluminescence spectroscopy. The mode of the out-of-plane field components of surface plasmon polaritons dominates the experimental mode patterns, indicating that the electron beam locally excites the out-of-plane field component of surface plasmon polaritons, and quality factors can be directly acquired. Numerous applications, such as plasmonic filter, nanolaser, and efficient light-emitting devices, can be expected to arise from these developments.
MicroRNAs dynamically remodel gastrointestinal smooth muscle cells.
Directory of Open Access Journals (Sweden)
Chanjae Park
2011-04-01
Full Text Available Smooth muscle cells (SMCs express a unique set of microRNAs (miRNAs which regulate and maintain the differentiation state of SMCs. The goal of this study was to investigate the role of miRNAs during the development of gastrointestinal (GI SMCs in a transgenic animal model. We generated SMC-specific Dicer null animals that express the reporter, green fluorescence protein, in a SMC-specific manner. SMC-specific knockout of Dicer prevented SMC miRNA biogenesis, causing dramatic changes in phenotype, function, and global gene expression in SMCs: the mutant mice developed severe dilation of the intestinal tract associated with the thinning and destruction of the smooth muscle (SM layers; contractile motility in the mutant intestine was dramatically decreased; and SM contractile genes and transcriptional regulators were extensively down-regulated in the mutant SMCs. Profiling and bioinformatic analyses showed that SMC phenotype is regulated by a complex network of positive and negative feedback by SMC miRNAs, serum response factor (SRF, and other transcriptional factors. Taken together, our data suggest that SMC miRNAs are required for the development and survival of SMCs in the GI tract.
Smoothness of chewing jaw movements in adults with mandibular prognathism.
Yashiro, K; Takagi, M; Takada, K
2012-02-01
Indices such as smoothness, movement time, peak velocity, and symmetry of the velocity profile have been shown to be effective in explaining the degree of skilfulness of human saccadic eye, limb, and jaw motions. We investigated whether adult subjects with mandibular prognathism show impaired smoothness of the masticatory jaw movements. Forty-nine adults with skeletal Class III malocclusions and 52 healthy adults with acceptably good occlusions were selected respectively as Test and Control subjects. Subjects of the Test Group were subdivided into two groups: Class III(closed) showed full occlusal contact between the upper and lower teeth at the habitual intercuspal position, whereas Class III(open) showed inability of occlusal contact between the upper and lower anterior teeth. Each subject was asked to chew a piece of chewing gum. The normalised jerk-cost (NJC), movement duration, and tangential velocity profile during jaw-closing movements were compared between groups. Test Groups showed greater NJC (P Control Group did. Class III(closed) showed greater NJC (P Control Group. The jaw movement skilfulness of the prognathic patients decreases most drastically with existence of malocclusal contact between upper and lower anterior teeth. © 2011 Blackwell Publishing Ltd.
Biophysical induction of vascular smooth muscle cell podosomes.
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Na Young Kim
Full Text Available Vascular smooth muscle cell (VSMC migration and matrix degradation occurs with intimal hyperplasia associated with atherosclerosis, vascular injury, and restenosis. One proposed mechanism by which VSMCs degrade matrix is through the use of podosomes, transient actin-based structures that are thought to play a role in extracellular matrix degradation by creating localized sites of matrix metalloproteinase (MMP secretion. To date, podosomes in VSMCs have largely been studied by stimulating cells with phorbol esters, such as phorbol 12,13-dibutyrate (PDBu, however little is known about the physiological cues that drive podosome formation. We present the first evidence that physiological, physical stimuli mimicking cues present within the microenvironment of diseased arteries can induce podosome formation in VSMCs. Both microtopographical cues and imposed pressure mimicking stage II hypertension induce podosome formation in A7R5 rat aortic smooth muscle cells. Moreover, wounding using a scratch assay induces podosomes at the leading edge of VSMCs. Notably the effect of each of these biophysical stimuli on podosome stimulation can be inhibited using a Src inhibitor. Together, these data indicate that physical cues can induce podosome formation in VSMCs.
Directional bilateral filters for smoothing fluorescence microscopy images
Directory of Open Access Journals (Sweden)
Manasij Venkatesh
2015-08-01
Full Text Available Images obtained through fluorescence microscopy at low numerical aperture (NA are noisy and have poor resolution. Images of specimens such as F-actin filaments obtained using confocal or widefield fluorescence microscopes contain directional information and it is important that an image smoothing or filtering technique preserve the directionality. F-actin filaments are widely studied in pathology because the abnormalities in actin dynamics play a key role in diagnosis of cancer, cardiac diseases, vascular diseases, myofibrillar myopathies, neurological disorders, etc. We develop the directional bilateral filter as a means of filtering out the noise in the image without significantly altering the directionality of the F-actin filaments. The bilateral filter is anisotropic to start with, but we add an additional degree of anisotropy by employing an oriented domain kernel for smoothing. The orientation is locally adapted using a structure tensor and the parameters of the bilateral filter are optimized for within the framework of statistical risk minimization. We show that the directional bilateral filter has better denoising performance than the traditional Gaussian bilateral filter and other denoising techniques such as SURE-LET, non-local means, and guided image filtering at various noise levels in terms of peak signal-to-noise ratio (PSNR. We also show quantitative improvements in low NA images of F-actin filaments.
Anisotropy of the magnetic susceptibility of gallium
Pankey, T.
1960-01-01
The bulk magnetic susceptibilities of single gallium crystals and polycrystalline gallium spheres were measured at 25??C. The following anisotropic diamagnetic susceptibilities were found: a axis (-0.119??0. 001)??10-6 emu/g, b axis (-0.416??0.002)??10 -6 emu/g, and c axis (-0.229??0.001) emu/g. The susceptibility of the polycrystalline spheres, assumed to be the average value for the bulk susceptibility of gallium, was (-0.257??0.003)??10-6 emu/g at 25??C, and (-0.299??0.003)??10-6 emu/g at -196??C. The susceptibility of liquid gallium was (0.0031??0.001) ??10-6 emu/g at 30??C and 100??C. Rotational diagrams of the susceptibilities in the three orthogonal planes of the unit cell were not sinusoidal. The anisotropy in the single crystals was presumably caused by the partial overlap of Brillouin zone boundaries by the Fermi-energy surface. The large change in susceptibility associated with the change in state was attributed to the absence of effective mass influence in the liquid state. ?? 1960 The American Institute of Physics.
Absolute method of measuring magnetic susceptibility
Thorpe, A.; Senftle, F.E.
1959-01-01
An absolute method of standardization and measurement of the magnetic susceptibility of small samples is presented which can be applied to most techniques based on the Faraday method. The fact that the susceptibility is a function of the area under the curve of sample displacement versus distance of the magnet from the sample, offers a simple method of measuring the susceptibility without recourse to a standard sample. Typical results on a few substances are compared with reported values, and an error of less than 2% can be achieved. ?? 1959 The American Institute of Physics.
Interaction between smooth anticipation and saccades during ocular orientation in darkness.
Blohm, Gunnar; Missal, Marcus; Lefèvre, Philippe
2003-03-01
A saccade triggered during sustained smooth pursuit is programmed using retinal information about the relative position and velocity of the target with respect to the eye. Thus the smooth pursuit and saccadic systems are coordinated by using common retinal inputs. Yet, in the absence of retinal information about the relative motion of the eye with respect to the target, the question arises whether the smooth and saccadic systems are still able to be coordinated possibly by using extraretinal information to account for the saccadic and smooth eye movements. To address this question, we flashed a target during smooth anticipatory eye movements in darkness, and the subjects were asked to orient their visual axis to the remembered location of the flash. We observed multiple orientation saccades (typically 2-3) toward the memorized location of the flash. The first orienting saccade was programmed using only the position error at the moment of the flash, and the smooth eye movement was ignored. However, subsequent saccades executed in darkness compensated gradually for the smooth eye displacement (mean compensation congruent with 70%). This behavior revealed a 400-ms delay in the time course of orientation for the compensation of the ongoing smooth eye displacement. We conclude that extraretinal information about the smooth motor command is available to the saccadic system in the absence of visual input. There is a 400-ms delay for smooth movement integration, saccade programming and execution.
Airway smooth muscle, tidal stretches, and dynamically determined contractile states.
Fredberg, J J; Inouye, D; Miller, B; Nathan, M; Jafari, S; Raboudi, S H; Butler, J P; Shore, S A
1997-12-01
In the classic theory of airway lumen narrowing in asthma, active force in airway smooth muscle is presumed to be in static mechanical equilibrium with the external load against which the muscle has shortened. This theory is useful because it identifies the static equilibrium length toward which activated airway smooth muscle would tend if given enough time. The corresponding state toward which myosin-actin interactions would tend is called the latch state. But are the concepts of a static mechanical equilibrium and the latch state applicable in the setting of tidal loading, as occurs during breathing? To address this question, we have studied isolated, maximally contracted bovine tracheal smooth muscle subjected to tidal stretches imposed at 0.33 Hz. We measured the active force (F) and stiffness (E), which reflect numbers of actin-myosin interactions, and hysteresivity (eta) which reflects the rate of turnover of those interactions. When the amplitude of imposed tidal stretch (epsilon) was very small, 0.25% of muscle optimal length, the steady-state value of F approximated the isometric force, E was large, and eta was small. When epsilon was increased beyond 1%, however, F and E promptly decreased and eta promptly increased. The muscle could be maintained in these steady, dynamically determined contractile states for as long as the tidal stretches were sustained; when epsilon subsequently decreased back to 0.25%, F, E, and eta returned slowly toward their previous values. The provocative stretch amplitude required to cause active force or muscle stiffness to fall by half, or hysteresivity to double, was slightly greater than 2%. These observations are consistent with a direct effect of stretch upon bridge dynamics in which, with increasing tidal stretch amplitude, the number of actin-myosin interactions decreases and their rate of turnover increases. We conclude that the interactions of myosin with actin are at every instant tending toward those that would
Perales, Sonia; Alejandre, Ma José; Morales, Rogelio Palomino; Torres, Carolina; Linares, Ana
2010-07-14
Nutritional control of gene regulation guides the transformation of smooth muscle cells (SMC) into foam cells in atherosclerosis. Oxidative stress has been reported in areas of lipid accumulation, activating proliferation genes. Suppression of oxidative stress by antioxidant administration reduces this activation and the progression of lesions. We hypothesized that fish oil consumption may protect against atherosclerotic vascular disease. The study objective was to determine the effects of dietary cholesterol and fish-oil intake on the apoptotic pathways induced by 25-hydroxycholesterol (25-HC) in SMC cultures. An in vivo/in vitro cell model was used, culturing SMC isolated from chicks exposed to an atherogenic cholesterol-rich diet with 5% of cholesterol (SMC-Ch) alone or followed by an anti-atherogenic fish oil-rich diet with 10% of menhaden oil (SMC-Ch-FO) and from chicks on standard diet (SMC-C). Cells were exposed to 25-HC, studying apoptosis levels by flow cytometry (Annexin V) and expressions of caspase-3, c-myc, and p53 genes by quantitative real-time reverse transcriptase-polymerase chain reaction. Exposure to 25-HC produced apoptosis in all three SMC cultures, which was mediated by increases in caspase-3, c-myc, and p53 gene expression. Changes were more marked in SMC-Ch than in SMC-C, indicating that dietary cholesterol makes SMC more susceptible to 25-HC-mediated apoptosis. Expression of p53 gene was elevated in SMC-Ch-FO. This supports the proposition that endogenous levels of p53 protect SMC against apoptosis and possibly against the development of atherosclerosis. Fish oil attenuated the increase in c-myc levels observed in SMC-C and SMC-Ch, possibly through its influence on the expression of antioxidant genes. Replacement of a cholesterol-rich diet with a fish oil-rich diet produces some reversal of the cholesterol-induced changes, increasing the resistance of SMC to apoptosis.
Wang, Meili; Fu, Yi; Gao, Cheng; Jia, Yiting; Huang, Yaqian; Liu, Limei; Wang, Xian; Wang, Wengong; Kong, Wei
2016-09-16
Aging-related vascular dysfunction contributes to cardiovascular morbidity and mortality. Cartilage oligomeric matrix protein (COMP), a vascular extracellular matrix protein, has been described as a negative regulatory factor for the vascular aging-related processes including atherosclerosis and vascular calcification. However, whether COMP is implicated in the process of vascular aging remains unclear. Here, we identified a novel function of COMP in preventing vascular aging and vascular smooth muscle cells (VSMCs) senescence. Firstly, vascular COMP expression was decreased in three different senescence-accelerated mouse models and was also declining with age. COMP(-/-) mice displayed elevated senescence-associated markers expression, including p53, p21 and p16, in the aortas compared with their wild type (WT) littermates. In accordance, COMP deficiency induced aging-related vascular dysfunction as evidenced by the significantly reduced phenylephrine-induced contraction and increased vascular stiffness as evaluated by pulse wave velocity. The aortic wall of COMP(-/-) mice was susceptible to senescence by displaying senescence-associated β-galactosidase (SA β-gal) activity induced by periadventitial application of CaCl2 to the abdominal aorta. In vitro, COMP knockdown by small interfering (si) RNA led to the elevation of p53, p21 and p16 as well as SA β-gal activity in VSMCs after H2O2 stimulation. VSMCs isolated from COMP(-/-) mice showed elevated senescence-associated markers expression and supplement of COMP adenovirus to COMP-deficient VSMCs greatly rescued cellular senescence. Taken together, these findings revealed the essential role of COMP in retarding the development of vascular aging and VSMC senescence. Copyright © 2016 Elsevier Inc. All rights reserved.
Directory of Open Access Journals (Sweden)
Sonia Perales
2009-01-01
Full Text Available Smooth muscle cells (SMCs undergo changes related to proliferation and apoptosis in the physiological remodeling of vessels and in diseases such as atherosclerosis and restenosis. Recent studies also have demonstrated the vascular cell proliferation and programmed cell death contribute to changes in vascular architecture in normal development and in disease. The present study was designed to investigate the apoptotic pathways induced by 25-hydroxycholesterol in SMCs cultures, using an in vivo/in vitro cell model in which SMCs were isolated and culture from chicken exposed to an atherogenic cholesterol-rich diet (SMC-Ch and/or an antiatherogenic fish oil-rich diet (SMC-Ch-FO. Cells were exposed in vitro to 25-hydroxycholesterol to study levels of apoptosis and apoptotic proteins Bcl-2, Bcl-XL and Bax and the expression of bcl-2 and bcl-xL, genes. The quantitative real-time reverse transcriptase-polymerase chain reaction and the Immunoblotting western blot analysis showed that 25-hydroxycholesterol produces apoptosis in SMCs, mediated by a high increase in Bax protein and Bax gene expression. These changes were more marked in SMC-Ch than in SMC-Ch-FO, indicating that dietary cholesterol produces changes in SMCs that make them more susceptible to 25-hydroxycholesterol-mediated apoptosis. Our results suggest that the replacement of a cholesterol-rich diet with a fish oil-rich diet produces some reversal of cholesterol-induced changes in the apoptotic pathways induced by 25-hydroxycholesterol in SMCs cultures, making SMCs more resistant to apoptosis.
Dynamics of Traction Force Reinforcement in Smooth Muscle Cells
Lin, Yi-Chia; Kramer, Corinne; Chen, Christopher; Reich, Daniel
2010-03-01
Mechanical forces influence cell function in various ways. For instance, the force-induced contraction or relaxation of vascular smooth muscle cells (SMCs) is critical to regulating the properties of blood vessels. Here, we study the dynamics of cellular traction forces in SMCs using micro-scale magnetic nanowires together with flexible PDMS micropost arrays. We use dual magnetic tweezers to apply a sinusoidal magnetic torque on nickel nanowires which are internalized by the SMCs. The spatial and temporal responses of the SMCs cultured on the tips of the microposts are recorded by the deflected posts. We observe a global reinforcement of the cells' traction forces upon applying a localized torque via the nanowires. Interestingly, we also find that the contractile response depends on the frequency of the applied stimulation, with a greater percentage of the SMCs showing enhanced reinforcement at lower frequencies.
Efficient Estimation of Smooth Distributions From Coarsely Grouped Data
DEFF Research Database (Denmark)
Rizzi, Silvia; Gampe, Jutta; Eilers, Paul H C
2015-01-01
Ungrouping binned data can be desirable for many reasons: Bins can be too coarse to allow for accurate analysis; comparisons can be hindered when different grouping approaches are used in different histograms; and the last interval is often wide and open-ended and, thus, covers a lot of information...... in the tail area. Age group-specific disease incidence rates and abridged life tables are examples of binned data. We propose a versatile method for ungrouping histograms that assumes that only the underlying distribution is smooth. Because of this modest assumption, the approach is suitable for most...... to the estimation of rates when both the event counts and the exposures to risk are grouped....
Structure and Thermodynamics of Metal Clusters on Atomically Smooth Substrates.
Eckhoff, M; Schebarchov, D; Wales, D J
2017-10-23
We analyze the structure of model NiN and CuN clusters (N = 55, 147) supported on a variety of atomically smooth van der Waals surfaces. The global minima are mapped in the space of two parameters: (i) the laterally averaged surface stickiness, γ, which controls the macroscopic wetting angle, and (ii) the surface microstructure, which produces more subtle but important templating via epitaxial stresses. We find that adjusting the substrate lattice (even at constant γ) can favor different crystal plane orientations in the cluster, stabilize hexagonal close-packed order, or induce various defects, such as stacking faults, twin boundaries, and five-fold disclinations. Thermodynamic analysis reveals substrate-dependent solid-solid transitions in cluster morphology, with tunable transition temperature and sometimes exhibiting re-entrant behavior. These results shed new light on the extent to which a supporting surface can be used to influence the equilibrium behavior of nanoparticles.
Modeling Electrokinetic Flows by the Smoothed Profile Method
Luo, Xian; Beskok, Ali; Karniadakis, George Em
2010-01-01
We propose an efficient modeling method for electrokinetic flows based on the Smoothed Profile Method (SPM) [1–4] and spectral element discretizations. The new method allows for arbitrary differences in the electrical conductivities between the charged surfaces and the the surrounding electrolyte solution. The electrokinetic forces are included into the flow equations so that the Poisson-Boltzmann and electric charge continuity equations are cast into forms suitable for SPM. The method is validated by benchmark problems of electroosmotic flow in straight channels and electrophoresis of charged cylinders. We also present simulation results of electrophoresis of charged microtubules, and show that the simulated electrophoretic mobility and anisotropy agree with the experimental values. PMID:20352076
Feature-preserving surface mesh smoothing via suboptimal Delaunay triangulation.
Gao, Zhanheng; Yu, Zeyun; Holst, Michael
2013-01-01
A method of triangular surface mesh smoothing is presented to improve angle quality by extending the original optimal Delaunay triangulation (ODT) to surface meshes. The mesh quality is improved by solving a quadratic optimization problem that minimizes the approximated interpolation error between a parabolic function and its piecewise linear interpolation defined on the mesh. A suboptimal problem is derived to guarantee a unique, analytic solution that is significantly faster with little loss in accuracy as compared to the optimal one. In addition to the quality-improving capability, the proposed method has been adapted to remove noise while faithfully preserving sharp features such as edges and corners of a mesh. Numerous experiments are included to demonstrate the performance of the method.
Day-Ahead Load Forecasting Using Exponential Smoothing
Directory of Open Access Journals (Sweden)
R. Bindiu
2009-12-01
Full Text Available The existence of a liberated market for electricity implies the necessity of using load forecasting in order to optimize and reduce the costs for the electric energy consumption. Different strategies for the purchase of electrical energy require precise load forecasting. The Day Ahead Market makes possible the acquisition of electricity for one day in advance. This reduces the risk of making electrical energy transactions on Balance Market, which means buying at a very high price and selling at a very low price. This paper presents a Day Ahead Load Forecasting approach for an industrial costumer using exponential smoothing method. The purpose of this paper is to present a new method for day ahead load forecasting.
Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications
Directory of Open Access Journals (Sweden)
Luke J Janssen
1997-01-01
Full Text Available Electrophysiological and pharmacological techniques were used to characterize the membrane conductance changes underlying spasmogen-evoked depolarization in airway smooth muscle (ASM. Changes included a transient activation of chloride ion channels and prolonged suppression of potassium ion channels; both changes are triggered by release of internally sequestered calcium ion and in turn cause opening of voltage-dependent calcium channels. The resultant influx of calcium ions contributes to contraction as well as to refilling of the internal calcium ion pool. Bronchodilators, on the other hand, act in part through activation of potassium channels, with consequent closure of calcium channels. The tools used to study ion channels in ASM are described, and the investigations of the roles of ion channels in ASM physiology (autacoid-evoked depolarization and hyperpolarization and pathophysiology (airway hyperresponsiveness are summarized. Finally, how the relationship between ion channels and ASM function/dysfunction may relate to the treatment of asthma and related breathing disorders is discussed.
Vascular smooth muscle function: defining the diabetic vascular phenotype.
Bruno, Rosa Maria; Ghiadoni, Lorenzo
2013-10-01
In this issue of Diabetologia, a meta-analysis performed by Montero and co-authors (Diabetologia doi 10.1007/s00125-013-2974-1 ) demonstrates a significant impairment of vascular smooth muscle (VSM) function in type 2 diabetic patients. Endothelial function and VSM function between type 2 diabetic and healthy individuals were associated, especially in the microcirculation, confirming the hypothesis that unresponsiveness of VSM cells to NO may amplify the consequences of reduced NO availability. This study suggests a novel interpretation for endothelial dysfunction in diabetic patients, indicating VSM cells as key players. Causative mechanisms of VSM dysfunction, which seems to be a feature of the vascular phenotype of type 2 diabetes mellitus, are largely unexplored in humans. Future studies should also address the crucial issue of the prognostic significance of VSM dysfunction in diabetic patients, and possibly in other conditions characterised by high cardiovascular risk.
Voltage harmonic elimination with RLC based interface smoothing filter
Chandrasekaran, K.; Ramachandaramurthy, V. K.
2015-04-01
A method is proposed for designing a Dynamic Voltage Restorer (DVR) with RLC interface smoothing filter. The RLC filter connected between the IGBT based Voltage Source Inverter (VSI) is attempted to eliminate voltage harmonics in the busbar voltage and switching harmonics from VSI by producing a PWM controlled harmonic voltage. In this method, the DVR or series active filter produces PWM voltage that cancels the existing harmonic voltage due to any harmonic voltage source. The proposed method is valid for any distorted busbar voltage. The operating VSI handles no active power but only harmonic power. The DVR is able to suppress the lower order switching harmonics generated by the IGBT based VSI. Good dynamic and transient results obtained. The Total Harmonic Distortion (THD) is minimized to zero at the sensitive load end. Digital simulations are carried out using PSCAD/EMTDC to validate the performance of RLC filter. Simulated results are presented.
Numerical modelling of extreme waves by Smoothed Particle Hydrodynamics
Directory of Open Access Journals (Sweden)
M. H. Dao
2011-02-01
Full Text Available The impact of extreme/rogue waves can lead to serious damage of vessels as well as marine and coastal structures. Such extreme waves in deep water are characterized by steep wave fronts and an energetic wave crest. The process of wave breaking is highly complex and, apart from the general knowledge that impact loadings are highly impulsive, the dynamics of the breaking and impact are still poorly understood. Using an advanced numerical method, the Smoothed Particle Hydrodynamics enhanced with parallel computing is able to reproduce well the extreme waves and their breaking process. Once the waves and their breaking process are modelled successfully, the dynamics of the breaking and the characteristics of their impact on offshore structures could be studied. The computational methodology and numerical results are presented in this paper.
Optimized first-order methods for smooth convex minimization.
Kim, Donghwan; Fessler, Jeffrey A
2016-09-01
We introduce new optimized first-order methods for smooth unconstrained convex minimization. Drori and Teboulle [5] recently described a numerical method for computing the N-iteration optimal step coefficients in a class of first-order algorithms that includes gradient methods, heavy-ball methods [15], and Nesterov's fast gradient methods [10,12]. However, the numerical method in [5] is computationally expensive for large N, and the corresponding numerically optimized first-order algorithm in [5] requires impractical memory and computation for large-scale optimization problems. In this paper, we propose optimized first-order algorithms that achieve a convergence bound that is two times smaller than for Nesterov's fast gradient methods; our bound is found analytically and refines the numerical bound in [5]. Furthermore, the proposed optimized first-order methods have efficient forms that are remarkably similar to Nesterov's fast gradient methods.
Numerical simulation of explosive welding using Smoothed Particle Hydrodynamics method
Directory of Open Access Journals (Sweden)
J Feng
2017-09-01
Full Text Available In order to investigate the mechanism of explosive welding and the influences of explosive welding parameters on the welding quality, this paper presents numerical simulation of the explosive welding of Al-Mg plates using Smoothed Particle Hydrodynamics method. The multi-physical phenomena of explosive welding, including acceleration of the flyer plate driven by explosive detonation, oblique collision of the flyer and base plates, jetting phenomenon and the formation of wavy interface can be reproduced in the simulation. The characteristics of explosive welding are analyzed based on the simulation results. The mechanism of wavy interface formation is mainly due to oscillation of the collision point on the bonding surfaces. In addition, the impact velocity and collision angle increase with the increase of the welding parameters, such as explosive thickness and standoff distance, resulting in enlargement of the interfacial waves.
A Consistent Adaptive-resolution Smoothed Particle Hydrodynamics Method
Pan, Wenxiao; Hu, Wei; Hu, Xiaozhe; Negrut, Dan; Univ of Wisconsin, Madison Collaboration; Tufts University Collaboration
2017-11-01
We seek to accelerate and increase the size of simulations for fluid-structure interactions (FSI) by using adaptive resolutions in the spatial discretization of the equations governing the time evolution of systems displaying two-way fluid-solid coupling. To this end, we propose an adaptive-resolution smoothed particle hydrodynamics (SPH) approach, in which spatial resolutions adaptively vary according to a recovery-based error estimator of velocity gradient as flow evolves. The second-order consistent discretization of spatial differential operators is employed to ensure the accuracy of the proposed method. The convergence, accuracy, and efficiency attributes of the new method are assessed by simulating different flows. In this process, the numerical results are compared to the analytical, finite element, and consistent SPH single-resolution solutions. We anticipate that the proposed adaptive-resolution method will enlarge the class of SPH-tractable FSI applications.
Memory-Based Learning Using Similarity for Smoothing
Zavrel, J; Zavrel, Jakub; Daelemans, Walter
1997-01-01
This paper analyses the relation between the use of similarity in Memory-Based Learning and the notion of backed-off smoothing in statistical language modeling. We show that the two approaches are closely related, and we argue that feature weighting methods in the Memory-Based paradigm can offer the advantage of automatically specifying a suitable domain-specific hierarchy between most specific and most general conditioning information without the need for a large number of parameters. We report two applications of this approach: PP-attachment and POS-tagging. Our method achieves state-of-the-art performance in both domains, and allows the easy integration of diverse information sources, such as rich lexical representations.
Smoothing effects for the filtration equation with different powers
Fotache, Alin Razvan; Muratori, Matteo
2017-09-01
We study the nonlinear diffusion equation ut = Δϕ (u) on general Euclidean domains, with homogeneous Neumann boundary conditions. We assume that ϕ‧ (u) is bounded from below by | u| m1 - 1 for small | u | and by | u| m2 - 1 for large | u |, the two exponents m1 ,m2 being possibly different and larger than one. The equality case corresponds to the well-known porous medium equation. We establish sharp short- and long-time L q0-L∞ smoothing estimates: similar issues have widely been investigated in the literature in the last few years, but the Neumann problem with different powers had not been addressed yet. This work extends some previous results in many directions.
Pattern recognition issues on anisotropic smoothed particle hydrodynamics
Pereira Marinho, Eraldo
2014-03-01
This is a preliminary theoretical discussion on the computational requirements of the state of the art smoothed particle hydrodynamics (SPH) from the optics of pattern recognition and artificial intelligence. It is pointed out in the present paper that, when including anisotropy detection to improve resolution on shock layer, SPH is a very peculiar case of unsupervised machine learning. On the other hand, the free particle nature of SPH opens an opportunity for artificial intelligence to study particles as agents acting in a collaborative framework in which the timed outcomes of a fluid simulation forms a large knowledge base, which might be very attractive in computational astrophysics phenomenological problems like self-propagating star formation.
Gasoline2: a modern smoothed particle hydrodynamics code
Wadsley, James W.; Keller, Benjamin W.; Quinn, Thomas R.
2017-10-01
The methods in the Gasoline2 smoothed particle hydrodynamics (SPH) code are described and tested. Gasoline2 is the most recent version of the Gasoline code for parallel hydrodynamics and gravity with identical hydrodynamics to the Changa code. As with other Modern SPH codes, we prevent sharp jumps in time-steps, use upgraded kernels and larger neighbour numbers and employ local viscosity limiters. Unique features in Gasoline2 include its Geometric Density Average Force expression, explicit Turbulent Diffusion terms and Gradient-Based shock detection to limit artificial viscosity. This last feature allows Gasoline2 to completely avoid artificial viscosity in non-shocking compressive flows. We present a suite of tests demonstrating the value of these features with the same code configuration and parameter choices used for production simulations.
A corrected solid boundary treatment method for Smoothed Particle Hydrodynamics
Chen, Yun-sai; Zheng, Xing; Jin, Shan-qin; Duan, Wen-yang
2017-04-01
Smoothed Particle Hydrodynamics method (SPH) has a good adaptability for simulating of free surface flow problems. However, there are some shortcomings of SPH which are still in open discussion. This paper presents a corrected solid boundary handling method for weakly compressible SPH. This improved method is very helpful for numerical stability and pressure distribution. Compared with other solid boundary handling methods, this corrected method is simpler for virtual ghost particle interpolation and the ghost particle evaluation relationship is clearer. Several numerical tests are given, like dam breaking, solitary wave impact and sloshing tank waves. The results show that the corrected solid boundary processing method can recover the spurious oscillations of pressure distribution when simulating the problems with complex geometry boundary.
Scaling laws for implicit viscosities in smoothed particle hydrodynamics
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Bierwisch Claas
2017-01-01
Full Text Available Smoothed particle hydrodynamics (SPH is a particle-based method which solves continuum equations such as the Navier-Stokes equations. A periodic fluidic system under homogeneous shear is studied using SPH in the present work. The total pressure of the system and the shear stress contributions from the SPH interaction terms for pressure and viscosity as well as the contribution caused by velocity fluctuations are analyzed. It is found that the pressure and the shear stress contributions obey certain scaling laws depending on physical properties of the system such as compressibility, viscosity and shear rate as well as the spatial resolution. Some of the identified relations resemble scaling laws for the rheology of dense granular flows. These findings render an assessment of the convergence with respect to the spatial resolution of SPH simulations possible. Furthermore, the similarities between numerical SPH particles and physical grains in dense flow provide a deeper understanding of the nature of the SPH method.
Scaling laws for implicit viscosities in smoothed particle hydrodynamics
Bierwisch, Claas; Polfer, Pit
2017-06-01
Smoothed particle hydrodynamics (SPH) is a particle-based method which solves continuum equations such as the Navier-Stokes equations. A periodic fluidic system under homogeneous shear is studied using SPH in the present work. The total pressure of the system and the shear stress contributions from the SPH interaction terms for pressure and viscosity as well as the contribution caused by velocity fluctuations are analyzed. It is found that the pressure and the shear stress contributions obey certain scaling laws depending on physical properties of the system such as compressibility, viscosity and shear rate as well as the spatial resolution. Some of the identified relations resemble scaling laws for the rheology of dense granular flows. These findings render an assessment of the convergence with respect to the spatial resolution of SPH simulations possible. Furthermore, the similarities between numerical SPH particles and physical grains in dense flow provide a deeper understanding of the nature of the SPH method.
On the problems of non-smooth railway vehicle dynamics
DEFF Research Database (Denmark)
Thomsen, Per Grove; True, Hans
2005-01-01
Railway vehicle dynamics is inherently a problem of nonlinear dynamics. The unavoidable nonlinearities stem from the rail/wheel contact geometry and the stress/strain velocity relation in the rail/wheel contact surface. In addition motion delimiters and dry friction contact between elements...... in the construction create discontinuities in the mathematical dynamic model. The stick/slip of dry friction can be modelled as a discontinuity or be smoothed whereby discontinuities of higher order spatial derivatives are introduced. Higher order discontinuities are also introduced through the rail/wheel contact...... relation. These discontinuities create problems for the advanced equation solvers that are needed for the numerical investigation of the nonlinear dynamic problem. The results of the integration of the dynamic system will depend on the correct choice and application of the solver. In the worst case...
Simulated Hypergravity Alters Vascular Smooth Muscle Cell Proliferation and Motility
Hunt, Shameka; Bettis, Barika; Harris-Hooker, Sandra; Sanford, Gary L.
1997-01-01
The cellular effects of gravity are poorly understood due to its constancy and nonavailability of altered gravitational models. Such an understanding is crucial for prolonged space flights. In these studies, we assessed the influence of centrifugation at 6G (HGrav) on vascular smooth muscle (SMC) mobility and proliferation. Cells were: (a) plated at low density and subjected to HGrav for 24-72 hr for proliferation studies, or (b) grown to confluency, subjected to HGrav, mechanically denuded and monitored for cell movement into the denuded area. Controls were maintained under normogravity. SMC showed a 50% inhibition of growth under HGrav and 10% serum; HGrav and low serum resulted in greater growth inhibition. The rate of movement of SMC into the denuded area was 2-3-fold higher under HGrav in low serum compared to controls, but similar in 10% serum. These studies show that HGrav has significant effects on SMC growth and mobility, which are dependent on serum levels.
CRKSPH - A Conservative Reproducing Kernel Smoothed Particle Hydrodynamics Scheme
Frontiere, Nicholas; Owen, J Michael
2016-01-01
We present a formulation of smoothed particle hydrodynamics (SPH) that employs a first-order consistent reproducing kernel function, exactly interpolating linear fields with particle tracers. Previous formulations using reproducing kernel (RK) interpolation have had difficulties maintaining conservation of momentum due to the fact the RK kernels are not, in general, spatially symmetric. Here, we utilize a reformulation of the fluid equations such that mass, momentum, and energy are all manifestly conserved without any assumption about kernel symmetries. Additionally, by exploiting the increased accuracy of the RK method's gradient, we formulate a simple limiter for the artificial viscosity that reduces the excess diffusion normally incurred by the ordinary SPH artificial viscosity. Collectively, we call our suite of modifications to the traditional SPH scheme Conservative Reproducing Kernel SPH, or CRKSPH. CRKSPH retains the benefits of traditional SPH methods (such as preserving Galilean invariance and manif...
Protostellar jets and magnetised turbulence with smoothed particle magnetohydrodynamics
Tricco, Terrence
2016-01-01
Magnetic fields are an integral component of the formation of stars. During my thesis work, I built new methods to model magnetic fields in smoothed particle magnetohydrodynamics which enforce the divergence-free constraint on the magnetic field and reduce numerical dissipation of the magnetic field. Using these methods, we have performed simulations of isolated protostar formation, studying the production of jets and outflows of material and their effect on transporting angular momentum away from the protostar and reducing the efficiency of star formation. A major code comparison project on the small-scale turbulent dynamo amplification of magnetic fields was performed, using conditions representative of molecular clouds, the formation site of stars. The results were compared against results from grid-based methods, finding excellent agreement on their statistics and qualitative behaviour. I will outline the numerical methods developed, and present the results from our protostar and molecular cloud simulations.
A smoothed string-like braneworld in six dimensions
Energy Technology Data Exchange (ETDEWEB)
Araujo, J.C.B.; Silva, J.E.G.; Veras, D.F.S.; Almeida, C.A.S. [Universidade Federal do Ceara, Departamento de Fisica, C.P. 6030, Fortaleza, Ceara (Brazil)
2015-03-01
We propose a static and axisymmetric braneworld in six dimensions as a string-like model extension. For a subtle warp function, this scenario provides near brane corrections. By varying the bulk cosmological constant, we obtain a source which passes through different phases. The solution is defined both for the interior and for the exterior of the string and satisfies all the energy conditions. A smoothed gravitational massless mode is localized on the brane, of which the core is displaced from the origin. In contrast to the thin-string model, the massive solutions have a high amplitude near the brane. Furthermore, by means of an analog quantum potential analysis, we show that only s-wave gravitational Kaluza-Klein modes are permissible. (orig.)
Prevalence and antimicrobial susceptibility of Extended Spectrum ...
African Journals Online (AJOL)
Lactamase (ESBL) producing gram-negative uropathogens in Sokoto, Nigeria. ... Antimicrobial susceptibility testing was determined using the modified Kirby Bauer method. Confirmation of ESBL phenotype was performed by Double-Disc Synergy Test ...
antimicrobial susceptibility pattern of extended spectrum
African Journals Online (AJOL)
JAMILU
ABSTRACT. The emergence of resistant strains of urogenital extended spectrum beta-lactamase producing ... antimicrobial susceptibility test using CLSI recommended, WHO modified Kirby Bauer disc diffusion method. ... Keywords: Extended Spectrum Beta-lactamases, Prevalence, Gram-negative urogenital isolates,.
antimicrobial susceptibility patterns of salmonella species in ...
African Journals Online (AJOL)
user
Empirical treatment for enteric fevers should, therefore, be discouraged while quinolones, cefepime, carbapenem, azithromycin and third generation cephalosporins be given preference. KEY WORDS: Susceptibility, Antimicrobial, Salmonella species, Enteric fever. INTRODUCTION. In the 21st century, enteric fever in the.
Human genetic susceptibility to Candida infections
Plantinga, T.S.; Johnson, M.D.; Scott, W.K.; Joosten, L.A.B.; Meer, J.W. van der; Perfect, J.R.; Kullberg, B.J.; Netea, M.G.
2012-01-01
Infections with Candida spp. have different manifestations in humans, ranging from mucosal to bloodstream and deep-seated disseminated infections. Immunocompromised patients have increased susceptibility to these types of infections, due to reduced capacity to elicit effective innate or adaptive
Real-Time Optical Antimicrobial Susceptibility Testing
DEFF Research Database (Denmark)
Fredborg, Marlene; Andersen, Klaus R; Jørgensen, Erik
2013-01-01
Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time, introdu......Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time......, introduces real-time detection of bacterial growth and antimicrobial susceptibility, with imaging material to support the automatically generated graphs. Automated antibiotic susceptibility tests of a monoculture showed statistically significant antibiotic effect within 6 minutes and within 30 minutes...
Smoothing internal migration age profiles for comparative research
Directory of Open Access Journals (Sweden)
Aude Bernard
2015-05-01
Full Text Available Background: Age patterns are a key dimension to compare migration between countries and over time. Comparative metrics can be reliably computed only if data capture the underlying age distribution of migration. Model schedules, the prevailing smoothing method, fit a composite exponential function, but are sensitive to function selection and initial parameter setting. Although non-parametric alternatives exist, their performance is yet to be established. Objective: We compare cubic splines and kernel regressions against model schedules by assessingwhich method provides an accurate representation of the age profile and best performs on metrics for comparing aggregate age patterns. Methods: We use full population microdata for Chile to perform 1,000 Monte-Carlo simulations for nine sample sizes and two spatial scales. We use residual and graphic analysis to assess model performance on the age and intensity at which migration peaks and the evolution of migration age patterns. Results: Model schedules generate a better fit when (1 the expected distribution of the age profile is known a priori, (2 the pre-determined shape of the model schedule adequately describes the true age distribution, and (3 the component curves and initial parameter values can be correctly set. When any of these conditions is not met, kernel regressions and cubic splines offer more reliable alternatives. Conclusions: Smoothing models should be selected according to research aims, age profile characteristics, and sample size. Kernel regressions and cubic splines enable a precise representation of aggregate migration age profiles for most sample sizes, without requiring parameter setting or imposing a pre-determined distribution, and therefore facilitate objective comparison.
Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells.
Directory of Open Access Journals (Sweden)
Peng-Fei Shan
Full Text Available Vascular calcification, which results from a process osteoblastic differentiation of vascular smooth muscle cells (VSMCs, is a major risk factor for cardiovascular morbidity and mortality. Apelin is a recently discovered peptide that is the endogenous ligand for the orphan G-protein-coupled receptor, APJ. Several studies have identified the protective effects of apelin on the cardiovascular system. However, the effects and mechanisms of apelin on the osteoblastic differentiation of VSMCs have not been elucidated. Using a culture of calcifying vascular smooth muscle cells (CVMSCs as a model for the study of vascular calcification, the relationship between apelin and the osteoblastic differentiation of VSMCs and the signal pathway involved were investigated. Alkaline phosphatase (ALP activity and osteocalcin secretion were examined in CVSMCs. The involved signal pathway was studied using the extracellular signal-regulated kinase (ERK inhibitor, PD98059, the phosphatidylinositol 3-kinase (PI3-K inhibitor, LY294002, and APJ siRNA. The results showed that apelin inhibited ALP activity, osteocalcin secretion, and the formation of mineralized nodules. APJ protein was detected in CVSMCs, and apelin activated ERK and AKT (a downstream effector of PI3-K. Suppression of APJ with siRNA abolished the apelin-induced activation of ERK and Akt. Furthermore, inhibition of APJ expression, and the activation of ERK or PI3-K, reversed the effects of apelin on ALP activity. These results showed that apelin inhibited the osteoblastic differentiation of CVSMCs through the APJ/ERK and APJ/PI3-K/AKT signaling pathway. Apelin appears to play a protective role against arterial calcification.
Kernel Smoothing Methods for Non-Poissonian Seismic Hazard Analysis
Woo, Gordon
2017-04-01
For almost fifty years, the mainstay of probabilistic seismic hazard analysis has been the methodology developed by Cornell, which assumes that earthquake occurrence is a Poisson process, and that the spatial distribution of epicentres can be represented by a set of polygonal source zones, within which seismicity is uniform. Based on Vere-Jones' use of kernel smoothing methods for earthquake forecasting, these methods were adapted in 1994 by the author for application to probabilistic seismic hazard analysis. There is no need for ambiguous boundaries of polygonal source zones, nor for the hypothesis of time independence of earthquake sequences. In Europe, there are many regions where seismotectonic zones are not well delineated, and where there is a dynamic stress interaction between events, so that they cannot be described as independent. From the Amatrice earthquake of 24 August, 2016, the subsequent damaging earthquakes in Central Italy over months were not independent events. Removing foreshocks and aftershocks is not only an ill-defined task, it has a material effect on seismic hazard computation. Because of the spatial dispersion of epicentres, and the clustering of magnitudes for the largest events in a sequence, which might all be around magnitude 6, the specific event causing the highest ground motion can vary from one site location to another. Where significant active faults have been clearly identified geologically, they should be modelled as individual seismic sources. The remaining background seismicity should be modelled as non-Poissonian using statistical kernel smoothing methods. This approach was first applied for seismic hazard analysis at a UK nuclear power plant two decades ago, and should be included within logic-trees for future probabilistic seismic hazard at critical installations within Europe. In this paper, various salient European applications are given.
Smoothed dissipative particle dynamics with angular momentum conservation
Energy Technology Data Exchange (ETDEWEB)
Müller, Kathrin, E-mail: k.mueller@fz-juelich.de; Fedosov, Dmitry A., E-mail: d.fedosov@fz-juelich.de; Gompper, Gerhard, E-mail: g.gompper@fz-juelich.de
2015-01-15
Smoothed dissipative particle dynamics (SDPD) combines two popular mesoscopic techniques, the smoothed particle hydrodynamics and dissipative particle dynamics (DPD) methods, and can be considered as an improved dissipative particle dynamics approach. Despite several advantages of the SDPD method over the conventional DPD model, the original formulation of SDPD by Español and Revenga (2003) [9], lacks angular momentum conservation, leading to unphysical results for problems where the conservation of angular momentum is essential. To overcome this limitation, we extend the SDPD method by introducing a particle spin variable such that local and global angular momentum conservation is restored. The new SDPD formulation (SDPD+a) is directly derived from the Navier–Stokes equation for fluids with spin, while thermal fluctuations are incorporated similarly to the DPD method. We test the new SDPD method and demonstrate that it properly reproduces fluid transport coefficients. Also, SDPD with angular momentum conservation is validated using two problems: (i) the Taylor–Couette flow with two immiscible fluids and (ii) a tank-treading vesicle in shear flow with a viscosity contrast between inner and outer fluids. For both problems, the new SDPD method leads to simulation predictions in agreement with the corresponding analytical theories, while the original SDPD method fails to capture properly physical characteristics of the systems due to violation of angular momentum conservation. In conclusion, the extended SDPD method with angular momentum conservation provides a new approach to tackle fluid problems such as multiphase flows and vesicle/cell suspensions, where the conservation of angular momentum is essential.
Seismic hazard estimation of northern Iran using smoothed seismicity
Khoshnevis, Naeem; Taborda, Ricardo; Azizzadeh-Roodpish, Shima; Cramer, Chris H.
2017-07-01
This article presents a seismic hazard assessment for northern Iran, where a smoothed seismicity approach has been used in combination with an updated seismic catalog and a ground motion prediction equation recently found to yield good fit with data. We evaluate the hazard over a geographical area including the seismic zones of Azerbaijan, the Alborz Mountain Range, and Kopeh-Dagh, as well as parts of other neighboring seismic zones that fall within our region of interest. In the chosen approach, seismic events are not assigned to specific faults but assumed to be potential seismogenic sources distributed within regular grid cells. After performing the corresponding magnitude conversions, we decluster both historical and instrumental seismicity catalogs to obtain earthquake rates based on the number of events within each cell, and smooth the results to account for the uncertainty in the spatial distribution of future earthquakes. Seismicity parameters are computed for each seismic zone separately, and for the entire region of interest as a single uniform seismotectonic region. In the analysis, we consider uncertainties in the ground motion prediction equation, the seismicity parameters, and combine the resulting models using a logic tree. The results are presented in terms of expected peak ground acceleration (PGA) maps and hazard curves at selected locations, considering exceedance probabilities of 2 and 10% in 50 years for rock site conditions. According to our results, the highest levels of hazard are observed west of the North Tabriz and east of the North Alborz faults, where expected PGA values are between about 0.5 and 1 g for 10 and 2% probability of exceedance in 50 years, respectively. We analyze our results in light of similar estimates available in the literature and offer our perspective on the differences observed. We find our results to be helpful in understanding seismic hazard for northern Iran, but recognize that additional efforts are necessary to
Highly smooth Nb surfaces fabricated by buffered electropolishing
Energy Technology Data Exchange (ETDEWEB)
Andy T. Wu; John Mammossor; H. Phillips; Jean Delayen; Charles Reece; Amy Wilkerson; David Smith; Robert Ike
2005-05-01
It is demonstrated that highly smooth Nb surfaces can be obtained through Buffered ElectroPolishing (BEP) employing an electrolyte consisting of lactic, sulfuric, and hydrofluoric acids. Parameters that control the polishing process are optimized to achieve the smoothest surface finish with the help of surface observations using a scanning electron microscope and a Metallographic Optical Microscope (MOM). The polishing rate of BEP is determined to be 0.646 {micro}m/min that is much higher than 0.381 {micro}m/min achieved by the conventional ElectroPolishing (EP) process widely used in the Superconducting Radio Frequency (SRF) community. A high precision and large scan area 3-D profilometer is used to view morphology of the treated Nb surfaces. Statistical data, such as, rms, total indicator runout, and arithmetic mean deviation of the Nb surfaces are extracted from the profilometer images. It is found that Nb surfaces treated by BEP are an order of magnitude smoother than those treated by the optimized EP process. The chemical composition of the Nb surfaces after BEP is analyzed by static and dynamic Secondary Ion Mass Spectrometer (SIMS) systems. Cracking patterns of the Nb surfaces under different primary ion sources of Ga{sup +}, Au{sup +}, and Ar{sup +} are reported. The depth profile of the surface niobium oxides is studied through continuously monitoring niobium and its relevant oxides' peaks as a function of time. Dynamic SIMS results imply that the surface oxide structure of Nb may be more complicated than what usually believed and can be inhomogeneous. Preliminary results of BEP on Nb SRF single cell cavities and half-cells are reported. It is shown that smooth and bright surfaces can be obtained in 30 minutes when the electric field inside a SRF cavity is uniform during a BEP process. This study reveals that BEP is a highly promising technique for surface treatment on Nb SRF cavities to be used in particle accelerators.
Oxygen mediates vascular smooth muscle relaxation in hypoxia.
Directory of Open Access Journals (Sweden)
Jessica Dada
Full Text Available The activation of soluble guanylate cyclase (sGC by nitric oxide (NO and other ligands has been extensively investigated for many years. In the present study we considered the effect of molecular oxygen (O2 on sGC both as a direct ligand and its affect on other ligands by measuring cyclic guanosine monophosphate (cGMP production, as an index of activity, as well as investigating smooth muscle relaxation under hypoxic conditions. Our isolated enzyme studies confirm the function of sGC is impaired under hypoxic conditions and produces cGMP in the presence of O2, importantly in the absence of NO. We also show that while O2 could partially affect the magnitude of sGC stimulation by NO when the latter was present in excess, activation by the NO independent, haem-dependent sGC stimulator 3-(5'-hydroxymethyl-2'-furyl-1-benzylindazole (YC-1 was unaffected. Our in vitro investigation of smooth muscle relaxation confirmed that O2 alone in the form of a buffer bolus (equilibrated at 95% O2/5% CO2 had the ability to dilate vessels under hypoxic conditions and that this was dependent upon sGC and independent of eNOS. Our studies confirm that O2 can be a direct and important mediator of vasodilation through an increase in cGMP production. In the wider context, these observations are key to understanding the relative roles of O2 versus NO-induced sGC activation.
Landslide susceptibility map: from research to application
Fiorucci, Federica; Reichenbach, Paola; Ardizzone, Francesca; Rossi, Mauro; Felicioni, Giulia; Antonini, Guendalina
2014-05-01
Susceptibility map is an important and essential tool in environmental planning, to evaluate landslide hazard and risk and for a correct and responsible management of the territory. Landslide susceptibility is the likelihood of a landslide occurring in an area on the basis of local terrain conditions. Can be expressed as the probability that any given region will be affected by landslides, i.e. an estimate of "where" landslides are likely to occur. In this work we present two examples of landslide susceptibility map prepared for the Umbria Region and for the Perugia Municipality. These two maps were realized following official request from the Regional and Municipal government to the Research Institute for the Hydrogeological Protection (CNR-IRPI). The susceptibility map prepared for the Umbria Region represents the development of previous agreements focused to prepare: i) a landslide inventory map that was included in the Urban Territorial Planning (PUT) and ii) a series of maps for the Regional Plan for Multi-risk Prevention. The activities carried out for the Umbria Region were focused to define and apply methods and techniques for landslide susceptibility zonation. Susceptibility maps were prepared exploiting a multivariate statistical model (linear discriminant analysis) for the five Civil Protection Alert Zones defined in the regional territory. The five resulting maps were tested and validated using the spatial distribution of recent landslide events that occurred in the region. The susceptibility map for the Perugia Municipality was prepared to be integrated as one of the cartographic product in the Municipal development plan (PRG - Piano Regolatore Generale) as required by the existing legislation. At strategic level, one of the main objectives of the PRG, is to establish a framework of knowledge and legal aspects for the management of geo-hydrological risk. At national level most of the susceptibility maps prepared for the PRG, were and still are obtained
Directory of Open Access Journals (Sweden)
Raheela Akhtar1,2*, Yongqun O. He2, Charles B. Larson2, Zafar I. Chaudhary3 and Mansur ud-Din Ahmad4
2012-06-01
Full Text Available Brucella abortus lipopolysaccharide (LPS was isolated and purified from rough (RB51 and smooth (S2308 strains of Brucella. The LPS preparations were used to treat murine (RAW 264.7 macrophages in order to study their differential effects. Treated macrophages were tested by lysozyme release test (LRT, nitroblue tetrazolium test (NBT and nitric oxide (NO assay, respectively. Rough Brucella LPS induced significantly higher levels of lysozyme release, oxidative stress, and nitric oxide in murine macrophages than smooth Brucella LPS or combined LPS (rough + smooth LPS. These responses were dose-dependent. Macrophages treated with rough LPS were more Brucellacidal than those treated with smooth LPS. The minimal stimulation of murine macrophages by Brucella smooth LPS may provide basis for less active immune responses against smooth strains.
Gao, Harry; Kaweesa, Dorcas V.; Moore, Jacob; Meisel, Nicholas A.
2017-03-01
Acetone vapor smoothing is a chemical treatment that "melts" the surface of additively manufactured acrylonitrile butadiene styrene parts. The process fuses layers together and allows them to reform when vapor is removed, resulting in a smooth surface finish. Although commonly used to improve aesthetics, recent work has begun to investigate the effects of vapor smoothing on part strength. Nevertheless, most of this work has failed to take into account the anisotropic nature of printed parts. Prior research has shown that vapor smoothing reduces strength under best-case loading conditions, when the tensile load is parallel with the direction of the layers. In this article, the authors hypothesize that vapor smoothing may increase strength under nonoptimal loading conditions as a result of increased cohesion between layers and a reduction in stress concentrations. They use a design of experiments approach to identify the combined impact of printing and vapor smoothing parameters on part material properties.
[Phenotypic modulation of corpus cavernous smooth musle cells and its influencing factors].
Chen, Gang; Lü, Bo-dong; Huang, Xiao-jun
2010-03-01
Corpus cavernous smooth muscle cells are the main functional component of the corpus cavernosum penis, whose phenotypic modulation is the key initial step in the proliferation and migration of smooth muscle cells. Therefore, an insight into the mechanism of the phenotypic modulation of smooth muscle cells and its influencing factors is important for the prevention and management of penis erectile dysfunction. Smooth muscle cells are generally divided into contracting (differentiated) and composing (undifferentiated, proliferated or dedifferentiated) types. It is found that TGF-beta, transcription factor E2F1, BTEB2 and insulin may affect the phenotypic modulation of smooth muscle cells. This paper presents an overview of the progress in the researches on the phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors.
Exact Filling of Figures with the Derivatives of Smooth Mappings Between Banach Spaces
Czech Academy of Sciences Publication Activity Database
Azagra, D.; Fabian, Marián; Jiménez-Sevilla, M.
2005-01-01
Roč. 48, č. 4 (2005), s. 481-499 ISSN 0008-4395 R&D Projects: GA AV ČR(CZ) IAA1019003; GA ČR(CZ) GA201/01/1198 Institutional research plan: CEZ:AV0Z10190503 Keywords : n-times smooth * Fréchet smooth * Gateaux smooth bump Subject RIV: BA - General Mathematics Impact factor: 0.316, year: 2005
A Pragmatic Smoothing Method for Improving the Quality of the Results in Atomic Spectroscopy
Bennun, Leonardo
2016-01-01
A new smoothing method for the improvement on the identification and quantification of spectral functions based on the previous knowledge of the signals that are expected to be quantified, is presented. These signals are used as weighted coefficients in the smoothing algorithm. This smoothing method was conceived to be applied in atomic and nuclear spectroscopies preferably to these techniques where net counts are proportional to acquisition time, such as particle induced X-ray emission (PIXE...
Ebeling, H; White, D.A.; Rangarajan, F. V. N.
2006-01-01
An efficient algorithm for adaptive kernel smoothing (AKS) of two-dimensional imaging data has been developed and implemented using the Interactive Data Language (IDL). The functional form of the kernel can be varied (top-hat, Gaussian etc.) to allow different weighting of the event counts registered within the smoothing region. For each individual pixel the algorithm increases the smoothing scale until the signal-to-noise ratio (s.n.r.) within the kernel reaches a preset value. Thus, noise i...
Rebriarina Hapsari; Vincentia Rizke Ciptaningtyas; Masfiyah Masfiyah
2012-01-01
Background: Rapid and accurate information on susceptibility of bacteria causing bacteraemia is very helpful in sepsis management. Blood culture is the gold standard for bacteraemia diagnosis. Standard antibiotic susceptibility testing needs at least three days for completion while direct method can give the result a day earlier. The aim of this study was to investigate the diagnostic value of direct antibiotic susceptibility testing in blood culture. Methods: Bloods from positive BACTEC b...
Components of the Hilbert scheme of space curves on low-degree smooth surfaces
Kleppe, Jan Oddvar; Ottem, John Christian
2015-01-01
We study maximal families W of the Hilbert scheme, H(d, g)sc, of smooth connected space curves whose general curve C lies on a smooth surface S of degree s. We give conditions on C under which W is a generically smooth component of H(d, g)sc and we determine dim W. If s = 4 and W is an irreducible component of H(d, g)sc, then the Picard number of S is at most 2 and we explicitly describe, also for s ≥ 5, non-reduced and generically smooth components in the case Pic(S) is generated by the clas...
Diagnosis of osteoarthritis by cartilage surface smoothness quantified automatically from knee MRI
DEFF Research Database (Denmark)
Tummala, Sudhakar; Bay-Jensen, Anne-Christine; Karsdal, Morten A.
2011-01-01
Objective: We investigated whether surface smoothness of articular cartilage in the medial tibiofemoral compartment quantified from magnetic resonance imaging (MRI) could be appropriate as a diagnostic marker of osteoarthritis (OA). Method: At baseline, 159 community-based subjects aged 21 to 81......, specifically cartilage volume from MRI, joint space width (JSW) from radiographs, and pain scores. Results: A total of 140 subjects concluded the 21-month study. Cartilage smoothness provided diagnostic ability in all compartments (P ... with pain severity (e.g., r = -0.32). The longitudinal change in smoothness was correlated with cartilage loss (r up to 0.60, P cartilage smoothness markers for diagnosis of moderate radiographic OA. Furthermore...
Energy Technology Data Exchange (ETDEWEB)
Hohenberger, M., E-mail: mhoh@lle.rochester.edu; Shvydky, A.; Marozas, J. A.; Bonino, M. J.; Canning, D.; Collins, T. J. B.; Dorrer, C.; Kessler, T. J.; Kruschwitz, B. E.; McKenty, P. W.; Regan, S. P.; Sangster, T. C.; Zuegel, J. D. [Laboratory for Laser Energetics, University of Rochester, 250 East River Road Rochester, Rochester, New York 14623 (United States); Fiksel, G. [Nuclear Engineering and Radiological Sciences (NERS), University of Michigan, Ann Arbor, Michigan 48109 (United States); Meyerhofer, D. D. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)
2016-09-15
Direct-drive ignition on the National Ignition Facility (NIF) requires single-beam smoothing to minimize imprinting of laser nonuniformities that can negatively affect implosion performance. One-dimensional, multi-FM smoothing by spectral dispersion (SSD) has been proposed to provide the required smoothing [Marozas et al., Bull. Am. Phys. Soc. 55, 294 (2010)]. A prototype multi-FM SSD system has been integrated into the NIF-like beamline of the OMEGA EP Laser System. Experiments have been performed to verify the smoothing performance by measuring Rayleigh–Taylor growth rates in planar targets of laser-imprinted and preimposed surface modulations. Multi-FM 1-D SSD has been observed to reduce imprint levels by ∼50% compared to the nominal OMEGA EP SSD system. The experimental results are in agreement with 2-D DRACO simulations using realistic, time-dependent far-field spot-intensity calculations that emulate the effect of SSD.
The effect of emotion on movement smoothness during gait in healthy young adults.
Kang, Gu Eon; Gross, M Melissa
2016-12-08
This study aimed to investigate the effect of emotion on movement smoothness during gait. We followed an autobiographical memories paradigm to induce four target emotions, neutral emotion, sadness, anger and joy, in eighteen healthy young adults. Participants performed gait trials while feeling the target emotions. We collected gait data using an eight-camera optoelectronic motion capture system. We measured spatiotemporal gait parameters, smoothness of linear movements for the whole body center-of-mass (COM), head, thorax and pelvis in the anterior-posterior (AP), vertical (VT) and mediolateral (ML) directions, and smoothness of angular movements in the sagittal plane for the shoulder, elbow, wrist, hip, knee and ankle. Movement smoothness was measured as jerk, the first time derivative to acceleration, normalized to movement distance and stride time. Compared to sadness, gait speed increased with anger and joy, and spatiotemporal parameters associated with increased gait speed changed accordingly. In the VT direction, movement smoothness in the whole body COM, head, thorax and pelvis increased for anger and joy compared to sadness. In the AP direction, movement smoothness increased only for the head for neutral emotion, anger and joy compared to sadness. In the ML direction, emotion did not affect movement smoothness. In angular movements, smoothness in the hip and ankle increased for anger compared to sadness. Smoothness in the shoulder increased for anger and joy compared to sadness. The present findings suggest that emotion affects movement smoothness during gait, and that anger and joy are associated with increased movement smoothness. Copyright © 2016 Elsevier Ltd. All rights reserved.
Adolescent neurobiological susceptibility to social context
Directory of Open Access Journals (Sweden)
Roberta A. Schriber
2016-06-01
Full Text Available Adolescence has been characterized as a period of heightened sensitivity to social contexts. However, adolescents vary in how their social contexts affect them. According to neurobiological susceptibility models, endogenous, biological factors confer some individuals, relative to others, with greater susceptibility to environmental influences, whereby more susceptible individuals fare the best or worst of all individuals, depending on the environment encountered (e.g., high vs. low parental warmth. Until recently, research guided by these theoretical frameworks has not incorporated direct measures of brain structure or function to index this sensitivity. Drawing on prevailing models of adolescent neurodevelopment and a growing number of neuroimaging studies on the interrelations among social contexts, the brain, and developmental outcomes, we review research that supports the idea of adolescent neurobiological susceptibility to social context for understanding why and how adolescents differ in development and well-being. We propose that adolescent development is shaped by brain-based individual differences in sensitivity to social contexts – be they positive or negative – such as those created through relationships with parents/caregivers and peers. Ultimately, we recommend that future research measure brain function and structure to operationalize susceptibility factors that moderate the influence of social contexts on developmental outcomes.
Adolescent Neurobiological Susceptibility to Social Context
Schriber, Roberta A.; Guyer, Amanda E.
2016-01-01
Adolescence has been characterized as a period of heightened sensitivity to social contexts. However, adolescents vary in how their social contexts affect them. According to neurobiological susceptibility models, endogenous, biological factors confer some individuals, relative to others, with greater susceptibility to environmental influences, whereby more susceptible individuals fare the best or worst of all individuals, depending on the environment they encounter (e.g., high vs. low parental warmth). Until recently, research guided by these theoretical frameworks has not incorporated direct measures of brain structure or function to index this sensitivity. Drawing on prevailing models of adolescent neurodevelopment and a growing number of neuroimaging studies on the interrelations among social contexts, the brain, and developmental outcomes, we review research that supports the idea of adolescent neurobiological susceptibility to social context for understanding why and how adolescents differ in development and well-being. We propose that adolescent development is shaped in part by brain-based individual differences in sensitivity to social contexts – be they positive or negative – such as those created through relationships with parents/caregivers and peers. As such, we recommend that future research measure brain function and structure to operationalize susceptibility factors that moderate the influence of social contexts on developmental outcomes. PMID:26773514
Susceptible-infected-susceptible epidemics on the complete graph and the star graph : Exact analysis
Cator, E.A.; Van Mieghem, P.
2013-01-01
Since mean-field approximations for susceptible-infected-susceptible (SIS) epidemics do not always predict the correct scaling of the epidemic threshold of the SIS metastable regime, we propose two novel approaches: (a) an ?-SIS generalized model and (b) a modified SIS model that prevents the
Simulating Magnetized Laboratory Plasmas with Smoothed Particle Hydrodynamics
Energy Technology Data Exchange (ETDEWEB)
Johnson, Jeffrey N. [Univ. of California, Davis, CA (United States)
2009-01-01
The creation of plasmas in the laboratory continues to generate excitement in the physics community. Despite the best efforts of the intrepid plasma diagnostics community, the dynamics of these plasmas remains a difficult challenge to both the theorist and the experimentalist. This dissertation describes the simulation of strongly magnetized laboratory plasmas with Smoothed Particle Hydrodynamics (SPH), a method born of astrophysics but gaining broad support in the engineering community. We describe the mathematical formulation that best characterizes a strongly magnetized plasma under our circumstances of interest, and we review the SPH method and its application to astrophysical plasmas based on research by Phillips [1], Buerve [2], and Price and Monaghan [3]. Some modifications and extensions to this method are necessary to simulate terrestrial plasmas, such as a treatment of magnetic diffusion based on work by Brookshaw [4] and by Atluri [5]; we describe these changes as we turn our attention toward laboratory experiments. Test problems that verify the method are provided throughout the discussion. Finally, we apply our method to the compression of a magnetized plasma performed by the Compact Toroid Injection eXperiment (CTIX) [6] and show that the experimental results support our computed predictions.
SREBP inhibits VEGF expression in human smooth muscle cells.
Motoyama, Koka; Fukumoto, Shinya; Koyama, Hidenori; Emoto, Masanori; Shimano, Hitoshi; Maemura, Koji; Nishizawa, Yoshiki
2006-03-31
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate expression of genes encoding enzymes for lipid biosynthesis. SREBPs are activated by HMG-CoA reductase inhibitors (statins). Statins have been also reported to suppress vascular endothelial growth factor (VEGF) expression in vascular smooth muscle cells (VSMCs). Therefore, we hypothesized that SREBPs are involved in statin-mediated regulation of VEGF production in VSMCs. SREBP1 was robustly expressed, and was activated by atorvastatin in VSMCs, as demonstrated by increased levels of the mature nuclear form of SREBP1, and increased promoter activities of a reporter containing sterol regulatory elements by atorvastatin. Moreover, overexpression of SREBP1a dose-dependently suppressed VEGF promoter activity. Site-specific mutation or deletion of the proximal Sp1 sites reduced the inhibitory effects of SREBP1a on VEGF promoter activity. These data demonstrated that SREBP1, activated by atorvastatin, suppressed VEGF expression through the indirect interaction with the proximal tandem Sp1 sites in VSMCs.
Smooth DNA transport through a narrowed pore geometry.
Carson, Spencer; Wilson, James; Aksimentiev, Aleksei; Wanunu, Meni
2014-11-18
Voltage-driven transport of double-stranded DNA through nanoscale pores holds much potential for applications in quantitative molecular biology and biotechnology, yet the microscopic details of translocation have proven to be challenging to decipher. Earlier experiments showed strong dependence of transport kinetics on pore size: fast regular transport in large pores (> 5 nm diameter), and slower yet heterogeneous transport time distributions in sub-5 nm pores, which imply a large positional uncertainty of the DNA in the pore as a function of the translocation time. In this work, we show that this anomalous transport is a result of DNA self-interaction, a phenomenon that is strictly pore-diameter dependent. We identify a regime in which DNA transport is regular, producing narrow and well-behaved dwell-time distributions that fit a simple drift-diffusion theory. Furthermore, a systematic study of the dependence of dwell time on DNA length reveals a single power-law scaling of 1.37 in the range of 35-20,000 bp. We highlight the resolution of our nanopore device by discriminating via single pulses 100 and 500 bp fragments in a mixture with >98% accuracy. When coupled to an appropriate sequence labeling method, our observation of smooth DNA translocation can pave the way for high-resolution DNA mapping and sizing applications in genomics.
Inflation and Topological Phase Transition Driven by Exotic Smoothness
Directory of Open Access Journals (Sweden)
Torsten Asselmeyer-Maluga
2014-01-01
Full Text Available We will discuss a model which describes the cause of inflation by a topological transition. The guiding principle is the choice of an exotic smoothness structure for the space-time. Here we consider a space-time with topology S3×ℝ. In case of an exotic S3×ℝ, there is a change in the spatial topology from a 3-sphere to a homology 3-sphere which can carry a hyperbolic structure. From the physical point of view, we will discuss the path integral for the Einstein-Hilbert action with respect to a decomposition of the space-time. The inclusion of the boundary terms produces fermionic contributions to the partition function. The expectation value of an area (with respect to some surface shows an exponential increase; that is, we obtain inflationary behavior. We will calculate the amount of this increase to be a topological invariant. Then we will describe this transition by an effective model, the Starobinski or R2 model which is consistent with the current measurement of the Planck satellite. The spectral index and other observables are also calculated.
Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling
El-Najjar, Nahed; Kulkarni, Rashmi P.; Nader, Nancy; Hodeify, Rawad
2017-01-01
Diabetes is a complex disease that is characterized with hyperglycemia, dyslipidemia, and insulin resistance. These pathologies are associated with significant cardiovascular implications that affect both the macro- and microvasculature. It is therefore important to understand the effects of various pathologies associated with diabetes on the vasculature. Here we directly test the effects of hyperglycemia on vascular smooth muscle (VSM) Ca2+ signaling in an isolated in vitro system using the A7r5 rat aortic cell line as a model. We find that prolonged exposure of A7r5 cells to hyperglycemia (weeks) is associated with changes to Ca2+ signaling, including most prominently an inhibition of the passive ER Ca2+ leak and the sarcoplasmic reticulum Ca2+-ATPase (SERCA). To translate these findings to the in vivo condition, we used primary VSM cells from normal and diabetic subjects and find that only the inhibition of the ER Ca2+ leaks replicates in cells from diabetic donors. These results show that prolonged hyperglycemia in isolation alters the Ca2+ signaling machinery in VSM cells. However, these alterations are not readily translatable to the whole organism situation where alterations to the Ca2+ signaling machinery are different. PMID:28713824
Dusty gas with one fluid in smoothed particle hydrodynamics
Laibe, Guillaume; Price, Daniel J.
2014-05-01
In a companion paper we have shown how the equations describing gas and dust as two fluids coupled by a drag term can be re-formulated to describe the system as a single-fluid mixture. Here, we present a numerical implementation of the one-fluid dusty gas algorithm using smoothed particle hydrodynamics (SPH). The algorithm preserves the conservation properties of the SPH formalism. In particular, the total gas and dust mass, momentum, angular momentum and energy are all exactly conserved. Shock viscosity and conductivity terms are generalized to handle the two-phase mixture accordingly. The algorithm is benchmarked against a comprehensive suit of problems: DUSTYBOX, DUSTYWAVE, DUSTYSHOCK and DUSTYOSCILL, each of them addressing different properties of the method. We compare the performance of the one-fluid algorithm to the standard two-fluid approach. The one-fluid algorithm is found to solve both of the fundamental limitations of the two-fluid algorithm: it is no longer possible to concentrate dust below the resolution of the gas (they have the same resolution by definition), and the spatial resolution criterion h limitation is that it does not capture multi-streaming of dust in the limit of zero coupling, suggesting that in this case a hybrid approach may be required.
Diet and scavenging habits of the smooth skate Dipturus innominatus.
Forman, J S; Dunn, M R
2012-04-01
The diet of smooth skate Dipturus innominatus was determined from examination of stomach contents of 321 specimens of 29·3-152·0 cm pelvic length, sampled from research and commercial trawlers at depths of 231-789 m on Chatham Rise, New Zealand. The diet was dominated by the benthic decapods Metanephrops challengeri and Munida gracilis, the natant decapod Campylonotus rathbunae and fishes from 17 families, of which hoki Macruronus novaezelandiae, sea perch Helicolenus barathri, various Macrouridae and a variety of discarded fishes were the most important. Multivariate analyses indicated the best predictors of diet variability were D. innominatus length and a spatial model. The diet of small D. innominatus was predominantly small crustaceans, with larger crustaceans, fishes and then scavenged discarded fishes increasing in importance as D. innominatus got larger. Scavenged discards were obvious as fish heads or tails only, or skeletal remains after filleting, often from pelagic species. Demersal fish prey were most frequent on the south and west Chatham Rise, in areas where commercial fishing was most active. Dipturus innominatus are highly vulnerable to overfishing, but discarding practices by commercial fishing vessels may provide a positive feedback to populations through improved scavenging opportunities. © 2012 NIWA. Journal of Fish Biology © 2012 The Fisheries Society of the British Isles.
Sparse Recovery using Smoothed $\\ell^0$ (SL0): Convergence Analysis
Mohimani, Hosein; Gorodnitsky, Irina; Jutten, Christian
2010-01-01
Finding the sparse solution of an underdetermined system of linear equations has many applications, especially, it is used in Compressed Sensing (CS), Sparse Component Analysis (SCA), and sparse decomposition of signals on overcomplete dictionaries. We have recently proposed a fast algorithm, called Smoothed $\\ell^0$ (SL0), for this task. Contrary to many other sparse recovery algorithms, SL0 is not based on minimizing the $\\ell^1$ norm, but it tries to directly minimize the $\\ell^0$ norm of the solution. The basic idea of SL0 is optimizing a sequence of certain (continuous) cost functions approximating the $\\ell^0$ norm of a vector. However, in previous papers, we did not provide a complete convergence proof for SL0. In this paper, we study the convergence properties of SL0, and show that under a certain sparsity constraint in terms of Asymmetric Restricted Isometry Property (ARIP), and with a certain choice of parameters, the convergence of SL0 to the sparsest solution is guaranteed. Moreover, we study the ...
Smoothing expansion rate data to reconstruct cosmological matter perturbations
Gonzalez, J. E.; Alcaniz, J. S.; Carvalho, J. C.
2017-08-01
The existing degeneracy between different dark energy and modified gravity cosmologies at the background level may be broken by analyzing quantities at the perturbative level. In this work, we apply a non-parametric smoothing (NPS) method to reconstruct the expansion history of the Universe (H(z)) from model-independent cosmic chronometers and high-z quasar data. Assuming a homogeneous and isotropic flat universe and general relativity (GR) as the gravity theory, we calculate the non-relativistic matter perturbations in the linear regime using the H(z) reconstruction and realistic values of Ωm0 and σ8 from Planck and WMAP-9 collaborations. We find a good agreement between the measurements of the growth rate and fσ8(z) from current large-scale structure observations and the estimates obtained from the reconstruction of the cosmic expansion history. Considering a recently proposed null test for GR using matter perturbations, we also apply the NPS method to reconstruct fσ8(z). For this case, we find a ~ 3σ tension (good agreement) with the standard relativistic cosmology when the Planck (WMAP-9) priors are used.
Simulating deposition of high density tailings using smoothed particle hydrodynamics
Babaoglu, Yagmur; Simms, Paul H.
2017-08-01
Tailings are a slurry of silt-sized residual material derived from the milling of rock. High density (HD) tailings are tailings that have been sufficiently dewatered to a point where they exhibit a yield stress upon deposition. They form gently sloped stacks on the surface when deposited; this eliminates or minimizes the need for dams or embankments for containment. Understanding the flow behaviour of high density tailings is essential for estimating the final stack geometry and overall slope angle. This paper focuses on modelling the flow behaviour of HD tailings using smoothed particle hydrodynamics (SPH) method incorporating a `bi-viscosity' model to simulate the non-Newtonian behaviour. The model is validated by comparing the numerical results with bench scale experiments simulating single or multi-layer deposits in two-dimensions. The results indicate that the model agreed fairly well with the experimental work, excepting some repulsion of particles away from the bottom boundary closer to the toe of the deposits. Novel aspects of the work, compared to other simulation of Bingham fluids by SPH, are the simulation of multilayer deposits and the use of a stopping criteria to characterize the rest state.
Impaired arterial smooth muscle cell vasodilatory function in methamphetamine users.
Nabaei, Ghaemeh; Oveisgharan, Shahram; Ghorbani, Askar; Fatehi, Farzad
2016-11-15
Methamphetamine use is a strong risk factor for stroke. This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically. In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-mediated dilatation (FMD) determinants of endothelium-dependent vasodilation, and nitroglycerine-mediated dilatation (NMD) independent marker of vasodilation were measured in two groups. There were no significant differences between the two groups regarding demographic and metabolic characteristics. The mean (±SD) CCA-IMT in methamphetamine users was 0.58±0.09mm, versus 0.59±0.07mm in the controls (p=0.84). Likewise, FMD% was not significantly different between the two groups [7.6±6.1% in methamphetamine users vs. 8.2±5.1% in the controls; p=0.72], nor were peak flow and shear rate after hyperemia. However, NMD% was considerably decreased in the methamphetamine users [8.5±7.8% in methamphetamine users vs. 13.4±6.2% in controls; p=0.03]. According to our results, NMD is reduced among otherwise healthy methamphetamine users, which represents smooth muscle dysfunction in this group. This may contribute to the high risk of stroke among methamphetamine users. Copyright © 2016 Elsevier B.V. All rights reserved.
Noise robust linear dynamic system for phase unwrapping and smoothing.
Estrada, Julio C; Servin, Manuel; Quiroga, Juan A
2011-03-14
Phase unwrapping techniques remove the modulus ambiguities of wrapped phase maps. The present work shows a first-order feedback system for phase unwrapping and smoothing. This system is a fast sequential unwrapping system which also allows filtering some noise because in deed it is an Infinite Impulse Response (IIR) low-pass filter. In other words, our system is capable of low-pass filtering the wrapped phase as the unwrapping process proceeds. We demonstrate the temporal stability of this unwrapping feedback system, as well as its low-pass filtering capabilities. Our system even outperforms the most common and used unwrapping methods that we tested, such as the Flynn's method, the Goldstain's method, and the Ghiglia least-squares method (weighted or unweighted). The comparisons with these methods shows that our system filters-out some noise while preserving the dynamic range of the phase-data. Its application areas may cover: optical metrology, synthetic aperture radar systems, magnetic resonance, and those imaging systems where information is obtained as a demodulated wrapped phase map.
Metal Diffusion in Smoothed Particle Hydrodynamics Simulations of Dwarf Galaxies
Williamson, David; Martel, Hugo; Kawata, Daisuke
2016-05-01
We perform a series of smoothed particle hydrodynamics simulations of isolated dwarf galaxies to compare different metal mixing models. In particular, we examine the role of diffusion in the production of enriched outflows and in determining the metallicity distributions of gas and stars. We investigate different diffusion strengths by changing the pre-factor of the diffusion coefficient, by varying how the diffusion coefficient is calculated from the local velocity distribution, and by varying whether the speed of sound is included as a velocity term. Stronger diffusion produces a tighter [O/Fe]-[Fe/H] distribution in the gas and cuts off the gas metallicity distribution function at lower metallicities. Diffusion suppresses the formation of low-metallicity stars, even with weak diffusion, and also strips metals from enriched outflows. This produces a remarkably tight correlation between “metal mass-loading” (mean metal outflow rate divided by mean metal production rate) and the strength of diffusion, even when the diffusion coefficient is calculated in different ways. The effectiveness of outflows at removing metals from dwarf galaxies and the metal distribution of the gas is thus dependent on the strength of diffusion. By contrast, we show that the metallicities of stars are not strongly dependent on the strength of diffusion, provided that some diffusion is present.
The interaction of otolith organ stimulation and smooth pursuit tracking.
Shelhamer, M; Young, L R
1994-01-01
The interaction of otolith organ stimulation and horizontal pursuit eye tracking in humans was studied in two different paradigms. In the first we measured the effects of lateral linear acceleration on ocular tracking of a retinal after-image, as compared to eye movements produced by acceleration alone (the linear VOR). The second paradigm determined the improvement in smooth oculomotor tracking presumably due to otolith input, by comparing tracking of an earth-fixed target during subject motion to tracking of target motion with the subject stationary. Subject and target motions in each case were sinusoidal. After-image tracking enhanced the gain of the linear VOR by a factor of 2 to 10. This is interpreted to mean that oculomotor efferent copy information is used to reconstruct an internal representation of target velocity, which is then tracked by the oculomotor system in the after-image condition. In the second paradigm, linear motion information transduced by the otolith organs combined with visual target information to yield improved oculomotor tracking over either system alone.
On the role of exponential smoothing in circadian dosimetry.
Price, Luke L A
2014-01-01
The effects lighting has on health through modulation of circadian rhythms are becoming increasingly well documented. Data are still needed to show how light exposures are influenced by architecture and lighting design and circadian dosimetry analyses should provide duration, phase and amplitude measures of 24 h exposure profiles. Exponential smoothing is used to derive suitable metrics from 24 h light measurements collected from private dwellings. A further application of these modified exposure time series as physiological models of the light drive is discussed. Unlike previous light drive models, the dose rate persists into periods of darkness following exposures. Comparisons to long duration exposure studies suggest this type of persistent light drive model could be incorporated into contemporary physiological models of the human circadian oscillator. © 2014 Crown copyright. Photochemistry and Photobiology © 2014 The American Society of Photobiology. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland and Public Health England.
Static and dynamic properties of smoothed dissipative particle dynamics
Alizadehrad, Davod; Fedosov, Dmitry A.
2018-03-01
In this paper, static and dynamic properties of the smoothed dissipative particle dynamics (SDPD) method are investigated. We study the effect of method parameters on SDPD fluid properties, such as structure, speed of sound, and transport coefficients, and show that a proper choice of parameters leads to a well-behaved and accurate fluid model. In particular, the speed of sound, the radial distribution function (RDF), shear-thinning of viscosity, the mean-squared displacement (〈R2 〉 ∝ t), and the Schmidt number (Sc ∼ O (103) - O (104)) can be controlled, such that the model exhibits a fluid-like behavior for a wide range of temperatures in simulations. Furthermore, in addition to the consideration of fluid density variations for fluid compressibility, a more challenging test of incompressibility is performed by considering the Poisson ratio and divergence of velocity field in an elongational flow. Finally, as an example of complex-fluid flow, we present the applicability and validity of the SDPD method with an appropriate choice of parameters for the simulation of cellular blood flow in irregular geometries. In conclusion, the results demonstrate that the SDPD method is able to approximate well a nearly incompressible fluid behavior, which includes hydrodynamic interactions and consistent thermal fluctuations, thereby providing, a powerful approach for simulations of complex mesoscopic systems.
Discussion of Stokes' hypothesis through the smoothed particle hydrodynamics model
Colagrossi, Andrea; Durante, Danilo; Bonet Avalos, Josep; Souto-Iglesias, Antonio
2017-08-01
Stokes' hypothesis, the zeroing of the bulk viscosity in a Newtonian fluid, is discussed in this paper. To this aim, a continuum macroscopic fluid domain is initially modeled as a Hamiltonian system of discrete particles, for which the interparticle dissipative forces are required to be radial in order to conserve the angular momentum. The resulting system of particles is then reconverted to the continuum domain via the framework of the smoothed particle hydrodynamics (SPH) model. Since an SPH-consistent approximation of the Newtonian viscous term in the momentum equation incorporates interparticle radial as well as nonradial terms, it is postulated that the latter must be null. In the present work it is shown that this constraint implies that first and second viscosities are equal, resulting in a positive value for the bulk viscosity, in contradiction to the cited Stokes' hypothesis. Moreover, it is found that this postulate leads to bulk viscosity coefficients close to values found in the experimental literature for monoatomic gases and common liquids such as water.
Numerical Simulation of Solitary Waves Using Smoothed Particle Hydrodynamics Method
Directory of Open Access Journals (Sweden)
Swapnadip De Chowdhury
2012-09-01
Full Text Available Understanding shallow water wave propagation is of major concern in any coastal mitigation effort. Many times, a solitary wave replicates a shallow water wave in its extreme sense which includes a tsunami wave. It is mainly due to known physical characteristics of such waves. Therefore, the study of propagation of solitary waves in the near shore waters is of equal importance in the context of non linear water waves. Owing to the significant growth in computational technologies in the last few decades, a significant number of numerical methods have emerged and applied to simulate nonlinear solitary wave propagation. In this study, one such method, the Smoothed Particle Hydrodynamics (SPH method has been described to simulate the solitary waves. The split-up of a single solitary wave while it crosses a continental kind of shelf has been simulated by the present model. Then SPH model is coupled with the Boussinesq model to predict the time interval between two successive solitary waves on landfall. It has also been shown to be equally efficient in simulating the wave breaking while a solitary wave propagates over a mild slope.
Computing characteristic classes of subschemes of smooth toric varieties
DEFF Research Database (Denmark)
Helmer, Martin
2017-01-01
Let XΣ be a smooth complete toric variety defined by a fan Σ and let V=V(I) be a subscheme of XΣ defined by an ideal I homogeneous with respect to the grading on the total coordinate ring of XΣ. We show a new expression for the Segre class s(V,XΣ) in terms of the projective degrees of a rational...... for the projective degrees of this rational map in terms of the dimension of an explicit quotient ring. Under an additional technical assumption we construct what we call a general dehomogenizing ideal and apply this construction to give effective algorithms to compute the Segre class s(V,XΣ), the Chern......–Schwartz–MacPherson class cSM(V) and the topological Euler characteristic χ(V) of V. These algorithms can, in particular, be used for subschemes of any product of projective spaces Pn1 ×⋯×Pnj or for subschemes of many other projective toric varieties. Running time bounds for several of the algorithms are given...
Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory.
Gomez, Delphine; Swiatlowska, Pamela; Owens, Gary K
2015-12-01
Vascular smooth muscle cells (SMCs), like all cells, acquire a cell-specific epigenetic signature during development that includes acquisition of a unique repertoire of histone and DNA modifications. These changes are postulated to induce an open chromatin state (referred to as euchromatin) on the repertoire of genes that are expressed in differentiated SMC, including SMC-selective marker genes like Acta2 and Myh11, as well as housekeeping genes expressed by most cell types. In contrast, genes that are silenced in differentiated SMC acquire modifications associated with a closed chromatin state (ie, heterochromatin) and transcriptional silencing. Herein, we review mechanisms that regulate epigenetic control of the differentiated state of SMC. In addition, we identify some of the major limitations in the field and future challenges, including development of innovative new tools and approaches, for performing single-cell epigenetic assays and locus-selective editing of the epigenome that will allow direct studies of the functional role of specific epigenetic controls during development, injury repair, and disease, including major cardiovascular diseases, such as atherosclerosis, hypertension, and microvascular disease, associated with diabetes mellitus. © 2015 American Heart Association, Inc.
Efficient Smoothed Concomitant Lasso Estimation for High Dimensional Regression
Ndiaye, Eugene; Fercoq, Olivier; Gramfort, Alexandre; Leclère, Vincent; Salmon, Joseph
2017-10-01
In high dimensional settings, sparse structures are crucial for efficiency, both in term of memory, computation and performance. It is customary to consider ℓ 1 penalty to enforce sparsity in such scenarios. Sparsity enforcing methods, the Lasso being a canonical example, are popular candidates to address high dimension. For efficiency, they rely on tuning a parameter trading data fitting versus sparsity. For the Lasso theory to hold this tuning parameter should be proportional to the noise level, yet the latter is often unknown in practice. A possible remedy is to jointly optimize over the regression parameter as well as over the noise level. This has been considered under several names in the literature: Scaled-Lasso, Square-root Lasso, Concomitant Lasso estimation for instance, and could be of interest for uncertainty quantification. In this work, after illustrating numerical difficulties for the Concomitant Lasso formulation, we propose a modification we coined Smoothed Concomitant Lasso, aimed at increasing numerical stability. We propose an efficient and accurate solver leading to a computational cost no more expensive than the one for the Lasso. We leverage on standard ingredients behind the success of fast Lasso solvers: a coordinate descent algorithm, combined with safe screening rules to achieve speed efficiency, by eliminating early irrelevant features.
Traction in smooth muscle cells varies with cell spreading
Tolic-Norrelykke, Iva Marija; Wang, Ning
2005-01-01
Changes in cell shape regulate cell growth, differentiation, and apoptosis. It has been suggested that the regulation of cell function by the cell shape is a result of the tension in the cytoskeleton and the distortion of the cell. Here we explore the association between cell-generated mechanical forces and the cell morphology. We hypothesized that the cell contractile force is associated with the degree of cell spreading, in particular with the cell length. We measured traction fields of single human airway smooth muscle cells plated on a polyacrylamide gel, in which fluorescent microbeads were embedded to serve as markers of gel deformation. The traction exerted by the cells at the cell-substrate interface was determined from the measured deformation of the gel. The traction was measured before and after treatment with the contractile agonist histamine, or the relaxing agonist isoproterenol. The relative increase in traction induced by histamine was negatively correlated with the baseline traction. On the contrary, the relative decrease in traction due to isoproterenol was independent of the baseline traction, but it was associated with cell shape: traction decreased more in elongated than in round cells. Maximum cell width, mean cell width, and projected area of the cell were the parameters most tightly coupled to both baseline and histamine-induced traction in this study. Wide and well-spread cells exerted larger traction than slim cells. These results suggest that cell contractility is controlled by cell spreading.
Smoothing spline ANOVA frailty model for recurrent event data.
Du, Pang; Jiang, Yihua; Wang, Yuedong
2011-12-01
Gap time hazard estimation is of particular interest in recurrent event data. This article proposes a fully nonparametric approach for estimating the gap time hazard. Smoothing spline analysis of variance (ANOVA) decompositions are used to model the log gap time hazard as a joint function of gap time and covariates, and general frailty is introduced to account for between-subject heterogeneity and within-subject correlation. We estimate the nonparametric gap time hazard function and parameters in the frailty distribution using a combination of the Newton-Raphson procedure, the stochastic approximation algorithm (SAA), and the Markov chain Monte Carlo (MCMC) method. The convergence of the algorithm is guaranteed by decreasing the step size of parameter update and/or increasing the MCMC sample size along iterations. Model selection procedure is also developed to identify negligible components in a functional ANOVA decomposition of the log gap time hazard. We evaluate the proposed methods with simulation studies and illustrate its use through the analysis of bladder tumor data. © 2011, The International Biometric Society.
Agronomic and chemical evaluation of smooth sumac, Rhus glabra
Energy Technology Data Exchange (ETDEWEB)
Campbell, T.A.
Smooth sumac (Rhus glabra) is a potential whole-plant source of polyphenol and oil. In a 2-yr evaluation of progenies from 14 Maryland, 1 northern Virginia, and 2 Georgia populations, highly significant variation (1% level) in vigor, number of plants surviving the seeding year, dry matter yield the seeding year, and number of tillers produced the second year was observed. In 15 entries, highly significant variation (1% level) in polyphenol + oil and in gallotannins was observed. Dry matter yields, extrapolated to Mg ha/sup -1/, ranged from 0.02 to 1.4 (for a single harvest), % polyphenol + oil from 19.4-31.1, and % gallotannins (a class of polyphenols) from 9.8 to 15.7. It is suggested that significantly improved lines could be developed through breeding. Based on estimated ratios of sigma/sup 2//sub Entries//sigma/sup 2//sub Entries/ + sigma/sup 2/, genetic variation for most agronomic traits could be estimated with fair precision whereas variation for chemical traits could be affected substantially by nongenetic factors. Factor analysis indicated plants that would perform reasonably well over a 2-yr period could be selected on the basis of early seeding-year vigor scores. Selection for high amount of polyphenol + oil and gallotannins would have to be done independently of agronomic selection. Cutting frequencies should not exceed 2 x yr/sup -1/ or serious stand loss would occur.
Impaired Arterial Smooth Muscle Cell Vasodilatory Function In Methamphetamine Users
Directory of Open Access Journals (Sweden)
Ghaemeh Nabaei
2017-02-01
Full Text Available Objectives: Methamphetamine use is a strong risk factor for stroke. This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically. Methods: In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT marker of early atherogenesis, flow-mediated dilatation (FMD determinants of endothelium-dependent vasodilation, and nitroglycerine-mediated dilatation (NMD independent marker of vasodilation were measured in two groups. Results: There were no significant differences between the two groups regarding demographic and metabolic characteristics. The mean (±SD CCA-IMT in methamphetamine users was 0.58±0.09mm, versus 0.59±0.07mm in the controls (p=0.84. Likewise, FMD% was not significantly different between the two groups [7.6±6.1% in methamphetamine users vs. 8.2±5.1% in the controls; p=0.72], nor were peak flow and shear rate after hyperemia. However, NMD% was considerably decreased in the methamphetamine users [8.5±7.8% in methamphetamine users vs. 13.4±6.2% in controls; p=0.03]. Conclusion: According to our results, NMD is reduced among otherwise healthy methamphetamine users, which represents smooth muscle dysfunction in this group. This may contribute to the high risk of stroke among methamphetamine users.
Prestretched airway smooth muscle response to length oscillation.
Al-Jumaily, Ahmed M; Roos, Kevin; Bessaguet, Sandy; Jo Avila, Miguel
2017-01-01
Airway smooth muscle (ASM) hyperconstriction is the cause of many respiratory diseases including asthma. In vitro testing has demonstrated that the active forces of ASM are reduced by length oscillation (LO) mimicking tidal breathing. In a previous study, we demonstrated that this force reduction can be further enhanced when superimposing oscillations (with certain frequencies and amplitudes) on this LO In contrast, it has been reported that pressurizing the lung may help in relieving asthmatic airway constrictions. Ultimately, this pressurizing stretches the ASM and may disturb the acto-myosin cross-bridges in a manner similar to LO; however, it is of a static rather than dynamic nature. This research investigates the effect of combining both prestretch- and LO-applications on contracted porcine ASM Isolated porcine ASM relaxation was tested with a 0.56%, 2%, or 4% stretch of its reference length (Lref) in addition to LO These oscillations are composed of a main wave mimicking the normal breathing (frequency of 0.33 Hz and amplitude of 4% Lref) and superimposed oscillations (frequencies of 20, 30, 40, 60 and 80 Hz and amplitude of 1% Lref). The oscillations were maintained for 10 min. The results demonstrate that a prestretch of 0.56% and 2% Lref does enhance the contracted ASM relaxation at certain superimposed length oscillations frequencies while of 4% Lref does not. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
Determination of adhesion forces between smooth and structured solids
Fischer, Hartmut R.; Gelinck, Edwin R. M.
2012-09-01
Surfaces tend to be made smoother in order to gain flatness or in order to fulfill the need for more precise and reproducible positioning of parts. Adhesion or even sticking of the surfaces is a major showstopper for these applications. There are several measures that can be taken in order to reduce spontaneous adhesion. Quantification of the effectiveness of the chosen solution is most often done using an atomic force microscope (AFM) with probes varying from 1 nm to 8 μm of contact diameter. A serious disadvantage in measuring adhesion by sharp tips is the wear of the tips. Sharp tips wear easily, resulting in undefined contact areas. When the real area of contact is not well defined, the quantification of the adhesion force is not significant. In the current study results of AFM measurements from literature with different tip diameters of colloidal probes are compared with AFM cantilevers with a plateau tip and using probes from large spheres using an alternative setup in combination with a Universal Nano-mechanical Analyzer (UNAT). Test results are shown. Another part of the study deals with a deliberately roughening of smooth surfaces to minimize (spontaneous) adhesion. Good agreement has been found with existing results.
A robust Kalman framework with resampling and optimal smoothing.
Kautz, Thomas; Eskofier, Bjoern M
2015-02-27
The Kalman filter (KF) is an extremely powerful and versatile tool for signal processing that has been applied extensively in various fields. We introduce a novel Kalman-based analysis procedure that encompasses robustness towards outliers, Kalman smoothing and real-time conversion from non-uniformly sampled inputs to a constant output rate. These features have been mostly treated independently, so that not all of their benefits could be exploited at the same time. Here, we present a coherent analysis procedure that combines the aforementioned features and their benefits. To facilitate utilization of the proposed methodology and to ensure optimal performance, we also introduce a procedure to calculate all necessary parameters. Thereby, we substantially expand the versatility of one of the most widely-used filtering approaches, taking full advantage of its most prevalent extensions. The applicability and superior performance of the proposed methods are demonstrated using simulated and real data. The possible areas of applications for the presented analysis procedure range from movement analysis over medical imaging, brain-computer interfaces to robot navigation or meteorological studies.
A Robust Kalman Framework with Resampling and Optimal Smoothing
Directory of Open Access Journals (Sweden)
Thomas Kautz
2015-02-01
Full Text Available The Kalman filter (KF is an extremely powerful and versatile tool for signal processing that has been applied extensively in various fields. We introduce a novel Kalman-based analysis procedure that encompasses robustness towards outliers, Kalman smoothing and real-time conversion from non-uniformly sampled inputs to a constant output rate. These features have been mostly treated independently, so that not all of their benefits could be exploited at the same time. Here, we present a coherent analysis procedure that combines the aforementioned features and their benefits. To facilitate utilization of the proposed methodology and to ensure optimal performance, we also introduce a procedure to calculate all necessary parameters. Thereby, we substantially expand the versatility of one of the most widely-used filtering approaches, taking full advantage of its most prevalent extensions. The applicability and superior performance of the proposed methods are demonstrated using simulated and real data. The possible areas of applications for the presented analysis procedure range from movement analysis over medical imaging, brain-computer interfaces to robot navigation or meteorological studies.
A Method for Low-Delay Pitch Tracking and Smoothing
DEFF Research Database (Denmark)
Christensen, Mads Græsbøll
2012-01-01
In this paper, a new method for pitch tracking is presented. The method is comprised of two steps. In the first step, accurate pitch estimates are obtained on a sample-by-sample basis by updates of the signal statistics with an exponential forgetting factor and subse- quent numerical optimization...... that require fast and sample-by-sample estimates, like tuners for musical instruments, transcription tasks requiring details like vi- brato, and real-time tracking of voiced speech.......In this paper, a new method for pitch tracking is presented. The method is comprised of two steps. In the first step, accurate pitch estimates are obtained on a sample-by-sample basis by updates of the signal statistics with an exponential forgetting factor and subse- quent numerical optimization....... In the second step, a Kalman filter is used to smooth the estimates and separate the pitch into a slowly varying component and a rapidly varying component. The former represents the mean pitch while the latter represents vibrato, slides and other fast changes. The method is intended for use in applica- tions...
van Engelen, E.
2008-01-01
Cervical ripening is a complex process of modification of cervical tissue that enables dilation of the cervix at parturition. Cervical smooth muscle tissue might play a role by contracting or by secretion of cytokines or MMPs. To assess a contractile role for the cervical smooth muscle cells in
Houwen, P.J. van der; Sommeijer, B.P.; Wubs, F.W.
1990-01-01
A smoothing technique for the “preconditioning” of the right-hand side of semidiscrete partial differential equations is analyzed. For a parabolic and a hyperbolic model problem, optimal smoothing matrices are constructed which result in a substantial amplification of the maximal stable integration
van Hoof, H.J.M.; Voss, H.P.; Kramer, K.; Boere, A.J.F.; Dormans, J.A.M.A.; van Bree, L.; Bast, A.
1997-01-01
We studied the effect of in vivo ozone inhalation (3 ppm, 2 h) on neuroreceptor function in guinea pig tracheal smooth muscle in vitro and the role of the epithelial layer in this process. Changes in smooth muscle tension after stimulation of the muscarinic- and β-adrenergic receptor were recorded
Directory of Open Access Journals (Sweden)
Luis Mello
2017-11-01
Full Text Available In this article we study the existence and positions of limit cycles in piecewise smooth perturbations of planar Hamiltonian centers. By using the regularization method we provide an analytical expression for the first order Melnikov function frequently used in the literature directly from the original non-smooth problem.
Vanaverbeke, S.; Keppens, R.; Poedts, S.; Boffin, H.
2009-01-01
We describe the algorithms implemented in the first version of GRADSPH, a parallel, tree-based, smoothed particle hydrodynamics code for simulating self-gravitating astrophysical systems written in FORTRAN 90. The paper presents details on the implementation of the Smoothed Particle Hydro (SPH)
Mast cell numbers in airway smooth muscle and PC(20)AMP in asthma and COPD
Liesker, J. J. W.; ten Hacken, N. H. T.; Rutgers, S. R.; Zeinstra-Smith, M.; Postma, D. S.; Timens, W.
Introduction: Most patients with asthma and many patients with COPD show bronchial hyperresponsiveness to adenosine (BHRAMP). BHRAMP may be caused by release of mast cell histamine, which induces smooth muscle contraction. Aim of the study: To evaluate whether mast cell numbers in airway smooth
Damage Mechanism in Counter Pairs Caused by Bionic Non-smoothed Surface
Directory of Open Access Journals (Sweden)
ZHANG Zhan-hui
2016-08-01
Full Text Available Four biomimetic non-smoothed surface specimens with different shapes were prepared by laser processing. Tests were conducted on MMU-5G wear and abrasion test machine to study the influencing rule of non-smoothed surfaces on counter pairs. The results show that the mass loss of the friction pair matching with the non-smoothed units is much greater than the ones matching with the smooth specimens. The pairs matching with different non-smoothed units suffer differently. The non-smoothed surface protruding zone exerts micro cutting on counter pairs. The striation causes the greatest mass loss of the pairs than the other non-smoothed units, which almost doubles the damage of the grid ones suffering the least. The difference in pairs damage is attributed to the different mechanism of undertaking the load in the process of wear. The damage can be alleviated effectively by changing the shapes of the units without increasing or decreasing the area ratio of the non-smoothed units.
Georgiev, Vladimir; Tarulli, Mirko
2005-01-01
We consider some scale invariant generalizations of the smoothing estimates for the free Schr\\"odnger equation obtained by Kenig, Ponce and Vega. Applying these estimates and using appropriate commutator estimates, we obtain similar scale invariant smoothing estimates for perturbed Schr\\"odnger equation with small magnetic potential.
Smoothing - Strichartz Estimates for the Schrodinger Equation with small Magnetic Potential
Georgiev, Vladimir; Stefanov, Atanas; Tarulli, Mirko
2005-01-01
The work treats smoothing and dispersive properties of solutions to the Schrodinger equation with magnetic potential. Under suitable smallness assumption on the potential involving scale invariant norms we prove smoothing - Strichartz estimate for the corresponding Cauchy problem. An application that guarantees absence of pure point spectrum of the corresponding perturbed Laplace operator is discussed too.
On the Significance of Demand and Inventory Smoothing Interventions in Supply Chain
Cannella, S.; Ciancimino, E.; Ashayeri, J.
2010-01-01
The aim of this paper is to quantify the benefit of demand and inventory smoothing in contrasting the extreme volatility and impetuous alteration of the market produced by the current economic recession. To do so we model a traditional supply chain and we test five settings of order smoothing under
Wright, D B; Tripathi, S; Sikarwar, A; Santosh, K T; Perez-Zoghbi, J; Ojo, O O; Irechukwu, N; Ward, J P T; Schaafsma, D
Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as
Direct evidence for a position input to the smooth pursuit system.
Blohm, Gunnar; Missal, Marcus; Lefèvre, Philippe
2005-07-01
When objects move in our environment, the orientation of the visual axis in space requires the coordination of two types of eye movements: saccades and smooth pursuit. The principal input to the saccadic system is position error, whereas it is velocity error for the smooth pursuit system. Recently, it has been shown that catch-up saccades to moving targets are triggered and programmed by using velocity error in addition to position error. Here, we show that, when a visual target is flashed during ongoing smooth pursuit, it evokes a smooth eye movement toward the flash. The velocity of this evoked smooth movement is proportional to the position error of the flash; it is neither influenced by the velocity of the ongoing smooth pursuit eye movement nor by the occurrence of a saccade, but the effect is absent if the flash is ignored by the subject. Furthermore, the response started around 85 ms after the flash presentation and decayed with an average time constant of 276 ms. Thus this is the first direct evidence of a position input to the smooth pursuit system. This study shows further evidence for a coupling between saccadic and smooth pursuit systems. It also suggests that there is an interaction between position and velocity error signals in the control of more complex movements.
A three critical point theorem for non-smooth functionals with ...
Indian Academy of Sciences (India)
Abstract. A variety of three-critical-point theorems have been established for non- smooth functionals, based on a minimax inequality. In this paper, a generalized form of a recent result due to Ricceri is introduced for non-smooth functionals and by a few hypotheses, without any minimax inequality, the existence of at least ...
Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent
Gosens, Reinout; Schaafsma, D.; Grootte Bromhaar, M.M; Vrugt, B.; Zaagsma, Hans; Meurs, Herman; Nelemans, Herman
2004-01-01
Growth factors have been implicated in the pathophysiology of asthma. However, the putative effects of these growth factors on human airway smooth muscle tone are still largely unknown. We performed contraction experiments using human bronchial smooth muscle ring preparations. The growth factor
Non-linear second-order periodic systems with non-smooth potential
Indian Academy of Sciences (India)
R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22
Abstract. In this paper we study second order non-linear periodic systems driven by the ordinary vector p-Laplacian with a non-smooth, locally Lipschitz potential function. Our approach is variational and it is based on the non-smooth critical point theory. We prove existence and multiplicity results under general growth ...
Non-linear second-order periodic systems with non-smooth potential
Indian Academy of Sciences (India)
In this paper we study second order non-linear periodic systems driven by the ordinary vector -Laplacian with a non-smooth, locally Lipschitz potential function. Our approach is variational and it is based on the non-smooth critical point theory. We prove existence and multiplicity results under general growth conditions on ...
Wijnberg, M.J.; Nieuwenbroek, N.M.E.; Slomp, J.; Quax, P.H.A.; Verheijen, J.H.
1996-01-01
The objective of this study was to investigate the role of the plasminogen activation system in the migration of human vascular smooth muscle cells in vitro. After wounding of confluent human smooth muscle cell cultures by stripping cells from their extracellular matrix, cells start to migrate from
Target Selection by the Frontal Cortex during Coordinated Saccadic and Smooth Pursuit Eye Movements
Srihasam, Krishna; Bullock, Daniel; Grossberg, Stephen
2009-01-01
Oculomotor tracking of moving objects is an important component of visually based cognition and planning. Such tracking is achieved by a combination of saccades and smooth-pursuit eye movements. In particular, the saccadic and smooth-pursuit systems interact to often choose the same target, and to maximize its visibility through time. How do…
A. Tudor (Alexandra)
2010-01-01
textabstractExecutive Summary This study investigates the level of income smoothing and its impact on the informativeness of earnings. The main contribution of this research is that as well IFRS as investor protection are considered to examine the association between income smoothing and earnings
Cell length measurements in longitudinal smooth muscle strips of the pig urinary bladder
E. van Asselt (Els); R. Schot (Rachel); R. van Mastrigt (Ron)
1993-01-01
textabstractIn this study the length of smooth muscle cells in muscle bundles of pig urinary bladder wall was determined after dissection in Tyrode buffers with different calcium concentrations ([Ca2+]). Previous studies have shown that the length of isolated smooth muscle cells decreases with an
Suppression of stochastic pulsation in laser-plasma interaction by smoothing methods
Energy Technology Data Exchange (ETDEWEB)
Hora, H. (PS-Division, CERN, CH1211 Geneva 23 (Switzerland)); Aydin, M. (Department of Theoretical Physics, University of New South Wales, Kensington 2033 (Australia))
1992-04-15
The control of the very complex behavior of a plasma with laser interaction by smoothing with induced spatial incoherence or other methods was related to improving the lateral uniformity of the irradiation. While this is important, it is shown from numerical hydrodynamic studies that the very strong temporal pulsation (stuttering) will mostly be suppressed by these smoothing methods too.
Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype
Dekkers, Bart G. J.; Schaafsma, Dedmer; Tran, Thai; Zaagsma, Johan; Meurs, Herman
2009-01-01
Airway smooth muscle (ASM) plays a key role in the development of airway hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells to a hypercontractile phenotype. In vitro studies have indicated that long-term exposure of bovine tracheal smooth muscle (BTSM) to insulin
DEFF Research Database (Denmark)
Rønnov-Jessen, Lone; Petersen, Ole William
1996-01-01
Actins are known to comprise six mammalian isoforms of which beta- and gamma-nonmuscle actins are present in all cells, whereas alpha-smooth muscle (alpha-sm) actin is normally restricted to cells of the smooth muscle lineages. alpha-Sm actin has been found also to be expressed transiently in cer...
Trajectory generation algorithm for smooth movement of a hybrid-type robot Rocker-Pillar
Energy Technology Data Exchange (ETDEWEB)
Jung, Seung Min; Choi, Dong Kyu; Kim, Jong Won [School of Mechanical and Aerospace Engineering, Seoul National University, Seoul (Korea, Republic of); Kim, Hwa Soo [Dept. of Mechanical System Engineering, Kyonggi University, Suwon (Korea, Republic of)
2016-11-15
While traveling on rough terrain, smooth movement of a mobile robot plays an important role in carrying out the given tasks successfully. This paper describes the trajectory generation algorithm for smooth movement of hybrid-type mobile robot Rocker-Pillar by adjusting the angular velocity of its caterpillar as well as each wheel velocity in such a manner to minimize a proper index for smoothness. To this end, a new Smoothness index (SI) is first suggested to evaluate the smoothness of movement of Rocker-Pillar. Then, the trajectory generation algorithm is proposed to reduce the undesired oscillations of its Center of mass (CoM). The experiment are performed to examine the movement of Rocker-Pillar climbing up the step whose height is twice larger than its wheel radius. It is verified that the resulting SI is improved by more than 40 % so that the movement of Rocker-Pillar becomes much smoother by the proposed trajectory algorithm.
Unfolding homoclinic connections formed by corner intersections in piecewise-smooth maps.
Simpson, D J W
2016-07-01
The stable and unstable manifolds of an invariant set of a piecewise-smooth map are themselves piecewise-smooth. Consequently, as parameters of a piecewise-smooth map are varied, an invariant set can develop a homoclinic connection when its stable manifold intersects a non-differentiable point of its unstable manifold (or vice-versa). This is a codimension-one bifurcation analogous to a homoclinic tangency of a smooth map, referred to here as a homoclinic corner. This paper presents an unfolding of generic homoclinic corners for saddle fixed points of planar piecewise-smooth continuous maps. It is shown that a sequence of border-collision bifurcations limits to a homoclinic corner and that all nearby periodic solutions are unstable.
Fidelity susceptibility as holographic PV-criticality
Energy Technology Data Exchange (ETDEWEB)
Momeni, Davood, E-mail: davoodmomeni78@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Faizal, Mir, E-mail: mirfaizalmir@googlemail.com [Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta T1K 3M4 (Canada); Irving K. Barber School of Arts and Sciences, University of British Columbia – Okanagan, 3333 University Way, Kelowna, British Columbia V1V 1V7 (Canada); Myrzakulov, Kairat, E-mail: kairatmyrzakul@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Myrzakulov, Ratbay, E-mail: rmyrzakulov@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan)
2017-02-10
It is well known that entropy can be used to holographically establish a connection among geometry, thermodynamics and information theory. In this paper, we will use complexity to holographically establish a connection among geometry, thermodynamics and information theory. Thus, we will analyze the relation among holographic complexity, fidelity susceptibility, and thermodynamics in extended phase space. We will demonstrate that fidelity susceptibility (which is the informational complexity dual to a maximum volume in AdS) can be related to the thermodynamical volume (which is conjugate to the cosmological constant in the extended thermodynamic phase space). Thus, this letter establishes a relation among geometry, thermodynamics, and information theory, using complexity.
Middle Prut plain's erosion susceptibility evaluation
Directory of Open Access Journals (Sweden)
Tudor CASTRAVEȚ
2011-07-01
Full Text Available The given article is dedicated to Middle Prut Plain’s erosion susceptibility evaluation using factorial analysis and methodology of principal component analysis implemented byGeographical Informational System GRASS. Susceptibility evaluation is executed in a qualitative mode, and the results have preliminary character, for further quantitative andmore precise study. This type of natural hazards analysis offers information on probable localization and severity of erosion phenomena, as well as their manifestation probabilityin a given place.
The Aging Kidney: Increased Susceptibility to Nephrotoxicity
Directory of Open Access Journals (Sweden)
Xinhui Wang
2014-09-01
Full Text Available Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI. Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.
Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function.
Muller-Delp, Judy M; Hotta, Kazuki; Chen, Bei; Behnke, Bradley Jon; Maraj, Joshua J; Delp, Michael D; Lucero, Tiffani R; Bramy, Jeremy A; Alarcon, David B; Morgan, Hannah E; Cowan, Morgan R; Haynes, Anthony D
2017-10-12
Coronary microvascular function and blood flow responses during acute exercise are impaired in the aged heart, but can be restored by exercise training. Coronary microvascular resistance is directly dependent on vascular smooth muscle function in coronary resistance arterioles; therefore, we hypothesized that age impairs contractile function and alters the phenotype of vascular smooth muscle in coronary arterioles. We further hypothesized that exercise training restores contractile function and reverses age-induced phenotypic alterations of arteriolar smooth muscle. Young and old Fischer 344 rats underwent 10 weeks of treadmill exercise training or remained sedentary. At the end of training or cage-confinement, contractile responses, vascular smooth muscle proliferation, and expression of contractile proteins were assessed in isolated coronary arterioles. Both receptor- and non-receptor-mediated contractile function were impaired in coronary arterioles from aged rats. Vascular smooth muscle shifted from a differentiated, contractile phenotype to a secretory phenotype with associated proliferation of smooth muscle in the arteriolar wall. Expression of smooth muscle myosin heavy chain 1 (SM1) was decreased in arterioles from aged rats; whereas expression of phospho-histone H3 and of the synthetic protein, ribosomal protein S6 (rpS6), were increased. Exercise training improved contractile responses, reduced smooth muscle proliferation and expression of rpS6, and increased expression of SM1 in arterioles from old rats. Thus, age-induced contractile dysfunction of coronary arterioles and emergence of a secretory smooth muscle phenotype may contribute to impaired coronary blood flow responses, but arteriolar contractile responsiveness and a younger smooth muscle phenotype can be restored with late-life exercise training. Copyright © 2017, Journal of Applied Physiology.
Topological susceptibility near $T_{c}$ in SU(3) gauge theory
Xiong, Guang-Yi; Chen, Ying; Liu, Chuan; Liu, Yu-Bin; Ma, Jian-Ping
2015-01-01
Topological charge susceptibility $\\chi_{t}$ for pure gauge SU(3) theory at finite temperature is studied using anisotropic lattices. The over-improved stout-link smoothing method is utilized to calculate the topological charge. Near the phase transition point we find a rapid declining behavior for $\\chi_{t}$ with values decreasing from $(188(1)\\mathrm{MeV})^{4}$ to $(67(3)\\mathrm{MeV})^{4}$ as the temperature increased from zero temperature to $1.9T_{c}$ which demonstrates the existence of topological excitations far above $T_{c}$. The 4th order cumulant $c_4$ of topological charge, as well as the ratio $c_4/\\chi_t$ are also investigated. Results of $c_4$ show step-like behavior near $T_c$ while the ratio at high temperature agrees with the value as predicted by the diluted instanton gas model.
Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation.
Naderi, Gholam Ali; Asgary, Seddigheh; Sarraf-Zadegan, Nizal; Shirvany, Hamid
2003-04-01
In vitro studies have demonstrated increased atherogenicity of oxidized low-density lipoprotein (ox-LDL) compared to native LDL. Oxidative modification of LDL alters its structure allowing LDL to be taken up by scavenger receptors on macrophage, endothelial, and smooth muscle cells, leading to the formation of lipid-laden foam cells, the hallmark of early atherosclerotic lesions. The susceptibility of LDL to in vitro oxidation was assessed essentially by the technique described by Esterbauer et al. LDL oxidation were monitored by change in 234-absorbance in the presence and absence of pure flavonoids. Morin, genistein, apigenin and biochanin A, naringin and quercetin were used at different concentration. These flavonoids significantly inhibit in vitro LDL oxidation, genistein, morin and naringin have stronger inhibitory activity against LDL oxidation than biochanin A or apigenin. This study show that flavonoids prevent in vitro LDL oxidation and probably would be important to prevent atherosclerosis.
Smoothed particle hydrodynamics method for evaporating multiphase flows.
Yang, Xiufeng; Kong, Song-Charng
2017-09-01
The smoothed particle hydrodynamics (SPH) method has been increasingly used for simulating fluid flows; however, its ability to simulate evaporating flow requires significant improvements. This paper proposes an SPH method for evaporating multiphase flows. The present SPH method can simulate the heat and mass transfers across the liquid-gas interfaces. The conservation equations of mass, momentum, and energy were reformulated based on SPH, then were used to govern the fluid flow and heat transfer in both the liquid and gas phases. The continuity equation of the vapor species was employed to simulate the vapor mass fraction in the gas phase. The vapor mass fraction at the interface was predicted by the Clausius-Clapeyron correlation. An evaporation rate was derived to predict the mass transfer from the liquid phase to the gas phase at the interface. Because of the mass transfer across the liquid-gas interface, the mass of an SPH particle was allowed to change. Alternative particle splitting and merging techniques were developed to avoid large mass difference between SPH particles of the same phase. The proposed method was tested by simulating three problems, including the Stefan problem, evaporation of a static drop, and evaporation of a drop impacting a hot surface. For the Stefan problem, the SPH results of the evaporation rate at the interface agreed well with the analytical solution. For drop evaporation, the SPH result was compared with the result predicted by a level-set method from the literature. In the case of drop impact on a hot surface, the evolution of the shape of the drop, temperature, and vapor mass fraction were predicted.
Kernel smoothing dos dados de chuva no Nordeste
Directory of Open Access Journals (Sweden)
Nyedja F. M. Barbosa
2014-07-01
Full Text Available O regime de chuvas sobre o Nordeste do Brasil é bastante complexo, sendo considerado sazonal, além de sofrer fortes influências dos fenômenos El Niño, La Niña e outros sistemas meteorológicos, como o dipolo, atuantes sobre as bacias do oceano Atlântico Tropical. Neste trabalho foi aplicada a técnica matemática-computacional de interpolação do Kernel Smoothing nos dados de precipitação pluvial sobre o Nordeste, coletados no período de 1904 a 1998, provenientes de 2.283 estações meteorológicas. Os cálculos foram desenvolvidos por meio do software "Kernel", escrito em linguagem C e Cuda o que possibilitou fazer a interpolação de mais de 26 milhões de medidas de precipitação pluvial, permitindo gerar mapas de intensidade de chuva sobre toda a região e calcular estatísticas para a precipitação do Nordeste em escalas mensais e anuais. De acordo com as interpolações realizadas foi possível detectar, dentre o período estudado, os anos mais secos e mais chuvosos, a distribuição espacial das chuvas em cada mês, bem como a característica da precipitação pluviométrica em épocas de El Niño e La Niña.
Mercury's Internal Magnetic Field: Modeling Core Fields with Smooth Inversions
Uno, H.; Johnson, C. L.; Anderson, B. J.; Korth, H.; Purucker, M. E.; Solomon, S. C.
2008-12-01
MESSENGER's second flyby (M2) of Mercury on 6 October 2008 will provide significantly improved geographical sampling of the planet's internal magnetic field over previous measurements. Latitudinal coverage and spacecraft altitudes will be similar to those during MESSENGER's first encounter (M1), but the spacecraft trajectory will be displaced by about 180° in longitude, yielding the first magnetic measurements in the western hemisphere. We investigate spatial structure in Mercury's internal magnetic field by applying methods from inverse theory to construct low-degree-and-order spherical harmonic models. External fields predicted by a parameterized magnetospheric model are subtracted from the vector field observations. The approach takes into account noise contributions from long-wavelength uncertainties in the external field models, unexplained short-wavelength features, and spacecraft attitude errors. We investigate the effect of different regularization (smoothness) constraints on our inversions. Analyses of data from M1 and the two Mariner 10 flybys that penetrated the magnetosphere yield a preferred spherical harmonic solution to degree and order eight with the centered, axial dipole term g10 dominating. The model shows structure at low and mid-latitude regions near the flybys. Terms predicted by an analytical model for long- wavelength crustal fields - namely g10, g30 and g32 - are present, but their relative amplitudes are not consistent with such a field. We conclude that structure in our models is dominated by core, rather than by crustal, fields. We also investigate, through simulations, field morphologies that are recoverable while the spacecraft is in orbit about Mercury, under the assumption that the long-wavelength contributions from external sources can be accurately modeled and removed. Although the elliptical orbit of MESSENGER will impede the recovery of southern hemisphere structure, we obtain excellent recovery of the dipole field and of
Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy
Directory of Open Access Journals (Sweden)
Lee Timothy DG
2010-06-01
Full Text Available Abstract Background Cardiac allograft vasculopathy (AV is a pathological process of vascular remodeling leading to late graft loss following cardiac transplantation. While there is consensus that AV is alloimmune mediated, and evidence that the most important alloimmune target is medial smooth muscle cells (SMC, the role of the innate immune response in the initiation of this disease is still being elucidated. As ischemia reperfusion (IR injury plays a pivotal role in the initiation of AV, we hypothesize that IR enhances the early innate response to cardiac allografts. Methods Aortic transplants were performed between fully disparate mouse strains (C3H/HeJ and C57BL/6, in the presence of therapeutic levels of Cyclosporine A, as a model for cardiac AV. Neutrophils were depleted from some recipients using anti-PMN serum. Grafts were harvested at 1,2,3,5d and 1,2wk post-transplant. Ultrastructural integrity was examined by transmission electron microscopy. SMC and neutrophils were quantified from histological sections in a blinded manner. Results Grafts exposed to cold ischemia, but not transplanted, showed no medial SMC loss and normal ultrastructural integrity. In comparison, allografts harvested 1d post-transplant exhibited > 90% loss of SMC (p Conclusions These novel data show that there is extensive damage to medial SMC at 1d post-transplant. By depleting neutrophils from recipients it was demonstrated that a portion of the SMC loss was mediated by neutrophils. These results provide evidence that IR activation of early innate events contributes to the etiology of AV.
Modeling of current distribution on smooth and columnar platinum structures.
Zinola, Carlos F
2011-01-17
Studying the growth and stability of anisotropic or isotropic disordered surfaces in electrodeposition is of importance in catalytic electrochemistry. In some cases, the metallic nature of the electrode defines the topography and roughness, which are also controlled by the experimental time and applied external potential. Because of the experimental restrictions in conventional electrochemical techniques and ex situ electron microscopies, a theoretical model of the surface geometry could aid in understanding the electrodeposition process and current distributions. In spite of applying a complex theory such as dynamic scaling method or perturbation theories, the resolution of mixed mass-/charge-transfer equations (tertiary distribution) for the electrodeposition process would give reliable information. One of the main problems with this type of distribution is the mathematics when solving the spatial n-dimensional differential equations. Use of a primary current distribution is proposed here to simplify the differential equations; however it limits wide application of the first assumption. Distributions of concentration profile, current density, and electrode potential are presented here as a function of the distance normal to the surface for the cases of smooth and rough platinum growth. In the particular case of columnar surfaces, cycloid curves are used to model the electrode, from which the concentration profile is presented in a parameterized form after solving a first-type curvilinear integral. The concentration contour results in a combination of a trigonometric inverse function and a linear distribution leading to a negative concavity curve. The calculation of the current density and electrode potential contours also show trigonometric shapes exhibiting forbidden imaginary values only at the minimal values of the trochoid curve. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts
Shi, Zhong-Dong; Tarbell, John M.
2011-01-01
Understanding how vascular wall endothelial cells (ECs), smooth muscle cells (SMCs), and fibroblasts (FBs) sense and transduce the stimuli of hemodynamic forces (shear stress, cyclic strain, and hydrostatic pressure) into intracellular biochemical signals is critical to prevent vascular disease development and progression. ECs lining the vessel lumen directly sense alterations in blood flow shear stress and then communicate with medial SMCs and adventitial FBs to regulate vessel function and disease. Shear stress mechanotransduction in ECs has been extensively studied and reviewed. In the case of endothelial damage, blood flow shear stress may directly act on the superficial layer of SMCs and transmural interstitial flow may be elevated on medial SMCs and adventitial FBs. Therefore, it is also important to investigate direct shear effects on vascular SMCs as well as FBs. The work published in the last two decades has shown that shear stress and interstitial flow have significant influences on vascular SMCs and FBs. This review summarizes work that considered direct shear effects on SMCs and FBs and provides the first comprehensive overview of the underlying mechanisms that modulate SMC secretion, alignment, contraction, proliferation, apoptosis, differentiation, and migration in response to 2-dimensional (2D) laminar, pulsatile, and oscillating flow shear stresses and 3D interstitial flow. A mechanistic model of flow sensing by SMCs is also provided to elucidate possible mechanotransduction pathways through surface glycocalyx, integrins, membrane receptors, ion channels, and primary cilia. Understanding flow-mediated mechanotransduction in SMCs and FBs and the interplay with ECs should be helpful in exploring strategies to prevent flow-initiated atherosclerosis and neointima formation and has implications in vascular tissue engineering. PMID:21479754
Multiresolution graph Fourier transform for compression of piecewise smooth images.
Hu, Wei; Cheung, Gene; Ortega, Antonio; Au, Oscar C
2015-01-01
Piecewise smooth (PWS) images (e.g., depth maps or animation images) contain unique signal characteristics such as sharp object boundaries and slowly varying interior surfaces. Leveraging on recent advances in graph signal processing, in this paper, we propose to compress the PWS images using suitable graph Fourier transforms (GFTs) to minimize the total signal representation cost of each pixel block, considering both the sparsity of the signal's transform coefficients and the compactness of transform description. Unlike fixed transforms, such as the discrete cosine transform, we can adapt GFT to a particular class of pixel blocks. In particular, we select one among a defined search space of GFTs to minimize total representation cost via our proposed algorithms, leveraging on graph optimization techniques, such as spectral clustering and minimum graph cuts. Furthermore, for practical implementation of GFT, we introduce two techniques to reduce computation complexity. First, at the encoder, we low-pass filter and downsample a high-resolution (HR) pixel block to obtain a low-resolution (LR) one, so that a LR-GFT can be employed. At the decoder, upsampling and interpolation are performed adaptively along HR boundaries coded using arithmetic edge coding, so that sharp object boundaries can be well preserved. Second, instead of computing GFT from a graph in real-time via eigen-decomposition, the most popular LR-GFTs are pre-computed and stored in a table for lookup during encoding and decoding. Using depth maps and computer-graphics images as examples of the PWS images, experimental results show that our proposed multiresolution-GFT scheme outperforms H.264 intra by 6.8 dB on average in peak signal-to-noise ratio at the same bit rate.
Neural mechanisms of smooth pursuit eye movements in schizotypy.
Meyhöfer, Inga; Steffens, Maria; Kasparbauer, Anna; Grant, Phillip; Weber, Bernd; Ettinger, Ulrich
2015-01-01
Patients with schizophrenia as well as individuals with high levels of schizotypy are known to have deficits in smooth pursuit eye movements (SPEM). Here, we investigated, for the first time, the neural mechanisms underlying SPEM performance in high schizotypy. Thirty-one healthy participants [N = 19 low schizotypes, N = 12 high schizotypes (HS)] underwent functional magnetic resonance imaging at 3T with concurrent oculographic recording while performing a SPEM task with sinusoidal stimuli at two velocities (0.2 and 0.4 Hz). Behaviorally, a significant interaction between schizotypy group and velocity was found for frequency of saccades during SPEM, indicating impairments in HS in the slow but not the fast condition. On the neural level, HS demonstrated lower brain activation in different regions of the occipital lobe known to be associated with early sensory and attentional processing and motion perception (V3A, middle occipital gyrus, and fusiform gyrus). This group difference in neural activation was independent of target velocity. Together, these findings replicate the observation of altered pursuit performance in highly schizotypal individuals and, for the first time, identify brain activation patterns accompanying these performance changes. These posterior activation differences are compatible with evidence of motion processing deficits from the schizophrenia literature and, therefore, suggest overlap between schizotypy and schizophrenia both on cognitive-perceptual and neurophysiological levels. However, deficits in frontal motor areas observed during pursuit in schizophrenia were not seen here, suggesting the operation of additional genetic and/or illness-related influences in the clinical disorder. © 2014 Wiley Periodicals, Inc.
Vascular smooth muscle cell hypertrophy induced by glycosylated human oxyhaemoglobin.
Peiró, C; Angulo, J; Rodríguez-Mañas, L; Llergo, J L; Vallejo, S; Cercas, E; Sánchez-Ferrer, C F
1998-10-01
1. Nonenzymatic protein glycosylation is a possible mechanism contributing to oxidative stress and vascular disease in diabetes. In this work, the influence of 14%-glycosylated human oxyhaemoglobin (GHHb), compared to the non-glycosylated protein (HHb), was studied on several growth parameters of rat cultured vascular smooth muscle cells (VSMC). A role for reactive oxygen species was also analysed. 2. Treatment of VSMC for 48 h with GHHb, but not with HHb, increased planar cell surface area in a concentration dependent manner. The threshold concentration was 10 nM, which increased cell size from 7965+/-176 to 9411+/-392 microm2. Similarly, only GHHb enhanced protein content per well in VSMC cultures. 3. The planar surface area increase induced by 10 nM GHHb was abolished by superoxide dismutase (SOD; 50 200 u ml(-1)), deferoxamine (100 nM-100 microM), or dimethylthiourea (1 mM), while catalase (50 200 u ml(-1)) or mannitol (1 mM) resulted in a partial inhibition of cell size enhancement. 4. When a known source of oxygen free radicals was administered to VSMC, the xanthine/xanthine oxidase system, the results were analogous to those produced by GHHb. Indeed, enhancements of cell size were observed, which were inhibited by SOD, deferoxamine, or catalase. 5. These results indicate that, at low concentrations, GHHb induces hypertrophy in VSMC, this effect being mediated by superoxide anions, hydrogen peroxide, and/or hydroxyl radicals. Therefore, glycosylated proteins can have a role in the development of the structural vascular alterations associated to diabetes by enhancing oxidative stress.
Vascular smooth muscle cell hypertrophy induced by glycosylated human oxyhaemoglobin
Peiró, Concepción; Angulo, Javier; Rodríguez-Mañas, Leocadio; Llergo, José L; Vallejo, Susana; Cercas, Elena; Sánchez-Ferrer, Carlos F
1998-01-01
Nonenzymatic protein glycosylation is a possible mechanism contributing to oxidative stress and vascular disease in diabetes. In this work, the influence of 14%-glycosylated human oxyhaemoglobin (GHHb), compared to the non-glycosylated protein (HHb), was studied on several growth parameters of rat cultured vascular smooth muscle cells (VSMC). A role for reactive oxygen species was also analysed.Treatment of VSMC for 48 h with GHHb, but not with HHb, increased planar cell surface area in a concentration dependent manner. The threshold concentration was 10 nM, which increased cell size from 7965±176 to 9411±392 μm2. Similarly, only GHHb enhanced protein content per well in VSMC cultures.The planar surface area increase induced by 10 nM GHHb was abolished by superoxide dismutase (SOD; 50–200 u ml−1), deferoxamine (100 nM–100 μM), or dimethylthiourea (1 mM), while catalase (50–200 u ml−1) or mannitol (1 mM) resulted in a partial inhibition of cell size enhancement.When a known source of oxygen free radicals was administered to VSMC, the xanthine/xanthine oxidase system, the results were analogous to those produced by GHHb. Indeed, enhancements of cell size were observed, which were inhibited by SOD, deferoxamine, or catalase.These results indicate that, at low concentrations, GHHb induces hypertrophy in VSMC, this effect being mediated by superoxide anions, hydrogen peroxide, and/or hydroxyl radicals. Therefore, glycosylated proteins can have a role in the development of the structural vascular alterations associated to diabetes by enhancing oxidative stress. PMID:9831896
Smoothed particle hydrodynamics method for evaporating multiphase flows
Yang, Xiufeng; Kong, Song-Charng
2017-09-01
The smoothed particle hydrodynamics (SPH) method has been increasingly used for simulating fluid flows; however, its ability to simulate evaporating flow requires significant improvements. This paper proposes an SPH method for evaporating multiphase flows. The present SPH method can simulate the heat and mass transfers across the liquid-gas interfaces. The conservation equations of mass, momentum, and energy were reformulated based on SPH, then were used to govern the fluid flow and heat transfer in both the liquid and gas phases. The continuity equation of the vapor species was employed to simulate the vapor mass fraction in the gas phase. The vapor mass fraction at the interface was predicted by the Clausius-Clapeyron correlation. An evaporation rate was derived to predict the mass transfer from the liquid phase to the gas phase at the interface. Because of the mass transfer across the liquid-gas interface, the mass of an SPH particle was allowed to change. Alternative particle splitting and merging techniques were developed to avoid large mass difference between SPH particles of the same phase. The proposed method was tested by simulating three problems, including the Stefan problem, evaporation of a static drop, and evaporation of a drop impacting a hot surface. For the Stefan problem, the SPH results of the evaporation rate at the interface agreed well with the analytical solution. For drop evaporation, the SPH result was compared with the result predicted by a level-set method from the literature. In the case of drop impact on a hot surface, the evolution of the shape of the drop, temperature, and vapor mass fraction were predicted.
Surface smoothing and template partitioning for cranial implant CAD
Min, Kyoung-june; Dean, David
2005-04-01
Employing patient-specific prefabricated implants can be an effective treatment for large cranial defects (i.e., > 25 cm2). We have previously demonstrated the use of Computer Aided Design (CAD) software that starts with the patient"s 3D head CT-scan. A template is accurately matched to the pre-detected skull defect margin. For unilateral cranial defects the template is derived from a left-to-right mirrored skull image. However, two problems arise: (1) slice edge artifacts generated during isosurface polygonalization are inherited by the final implant; and (2) partitioning (i.e., cookie-cutting) the implant surface from the mirrored skull image usually results in curvature discontinuities across the interface between the patient"s defect and the implant. To solve these problems, we introduce a novel space curve-to-surface partitioning algorithm following a ray-casting surface re-sampling and smoothing procedure. Specifically, the ray-cast re-sampling is followed by bilinear interpolation and low-pass filtering. The resulting surface has a highly regular grid-like topological structure of quadrilaterally arranged triangles. Then, we replace the regions to be partitioned with predefined sets of triangular elements thereby cutting the template surface to accurately fit the defect margin at high resolution and without surface curvature discontinuities. Comparisons of the CAD implants for five patients against the manually generated implant that the patient actually received show an average implant-patient gap of 0.45mm for the former and 2.96mm for the latter. Also, average maximum normalized curvature of interfacing surfaces was found to be smoother, 0.043, for the former than the latter, 0.097. This indicates that the CAD implants would provide a significantly better fit.
Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle
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Venkatachalem Sathish
2015-06-01
Full Text Available Aims: Cigarette smoke (CS in active smokers and second-hand smoke exposure exacerbate respiratory disorders such as asthma and chronic bronchitis. While women are known to experience a more asthmatic response to CS than emphysema in men, there is limited information on the mechanisms of CS-induced airway dysfunction. We hypothesize that CS interferes with a normal (protective bronchodilatory role of estrogens, thus worsening airway contractility. Methods: We tested effects of cigarette smoke extract (CSE on 17β-estradiol (E2 signaling in enzymatically-dissociated bronchial airway smooth muscle (ASM obtained from lung samples of non-smoking female patients undergoing thoracic surgery. Results: In fura-2 loaded ASM cells, CSE increased intracellular calcium ([Ca2+]i responses to 10µM histamine. Acute exposure to physiological concentrations of E2 decreased [Ca2+]i responses. However, in 24h exposed CSE cells, although expression of estrogen receptors was increased, the effect of E2 on [Ca2+]i was blunted. Acute E2 exposure also decreased store-operated Ca2+ entry and inhibited stromal interaction molecule 1 (STIM1 phosphorylation: effects blunted by CSE. Acute exposure to E2 increased cAMP, but less so in 24h CSE-exposed cells. 24h CSE exposure increased S-nitrosylation of ERα. Furthermore, 24h CSE-exposed bronchial rings showed increased bronchoconstrictor agonist responses that were not reduced as effectively by E2 compared to non-CSE controls. Conclusion: These data suggest that CS induces dysregulation of estrogen signaling in ASM, which could contribute to increased airway contractility in women exposed to CS.
Inhibition of tracheal smooth muscle cell proliferation by phosphodiesterase inhibitors
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Kazuko Masu
1999-01-01
Full Text Available Agents that increase intracellular cyclic 3',5'-adenosine monophosphate (cAMP, such as forskolin, prostaglandin (PGE2, salbutamol and 8-bromo-cAMP, have been shownto inhibit the proliferation of airway smooth-muscle (ASM cells in vitro. However, it has not yet been determined whether selective inhibitors of phosphodiesterase (PDE isoenzymes III and IV that catalyze cAMPto 5'-adenosine monophosphate have the ability to inhibit ASM cell proliferation. To evaluate the effectsof PDE inhibitors on ASM cell proliferation, ASM cells isolated from bovine tracheae were cultured in the presence of fetal bovine serum (FBS, with or without a non-selective PDE inhibitor (theophylline, a selective PDE III inhibitor (cilostazol, and a selective PDE IV inhibitor (rolipram. The number of ASM cells cultured with 5% FBS was significantly reduced by the presence of theophylline at 10−3 and 3 × 10−4 mol/L, cilostazol at 10−5, 10−6 and 10−7 mol/L, and rolipram at 10−4 and 10−5 mol/L. The release of lactic dehydrogenase from ASM cells cultured with any concentration of these agents was not significantly different from that with medium alone. Inhibitors of PDE III and IV were demonstrated to have an inhibitory effect on ASM cell proliferation induced by FBS. Our results suggest the value of the further development of PDE inhibitors for the treatment of hyperplasia of ASM cells characteristic of airway remodeling, in addition to bronchospasm and airway inflammation, in bronchial asthma.
Caveolae and propofol effects on airway smooth muscle
Grim, K. J.; Abcejo, A. J.; Barnes, A.; Sathish, V.; Smelter, D. F.; Ford, G. C.; Thompson, M. A.; Prakash, Y. S.; Pabelick, C. M.
2012-01-01
Background The i.v. anaesthetic propofol produces bronchodilatation. Airway relaxation involves reduced intracellular Ca2+ ([Ca2+]i) in airway smooth muscle (ASM) and lipid rafts (caveolae), and constitutional caveolin proteins regulate [Ca2+]i. We postulated that propofol-induced bronchodilatation involves caveolar disruption. Methods Caveolar fractions of human ASM cells were tested for propofol content. [Ca2+]i responses of ASM cells loaded with fura-2 were performed in the presence of 10 µM histamine with and without clinically relevant concentrations of propofol (10 and 30 μM and intralipid control). Effects on sarcoplasmic reticulum (SR) Ca2+ release were evaluated in zero extracellular Ca2+ using the blockers Xestospongin C and ryanodine. Store-operated Ca2+ entry (SOCE) after SR depletion was evaluated using established techniques. The role of caveolin-1 in the effect of propofol was tested using small interference RNA (siRNA) suppression. Changes in intracellular signalling cascades relevant to [Ca2+]i and force regulation were also evaluated. Results Propofol was present in ASM caveolar fractions in substantial concentrations. Exposure to 10 or 30 µM propofol form decreased [Ca2+]i peak (but not plateau) responses to histamine by ∼40%, an effect persistent in zero extracellular Ca2+. Propofol effects were absent in caveolin-1 siRNA-transfected cells. Inhibition of ryanodine receptors prevented propofol effects on [Ca2+]i, while propofol blunted [Ca2+]i responses to caffeine. Propofol reduced SOCE, an effect also prevented by caveolin-1 siRNA. Propofol effects were associated with decreased caveolin-1 expression and extracellular signal-regulated kinase phosphorylation. Conclusions These novel data suggest a role for caveolae (specifically caveolin-1) in propofol-induced bronchodilatation. Due to its lipid nature, propofol may transiently disrupt caveolar regulation, thus altering ASM [Ca2+]i. PMID:22542538
Genetics of Asthma Susceptibility and Severity
Slager, Rebecca E.; Hawkins, Gregory A.; Li, Xingnan; Postma, Dirkje S.; Meyers, Deborah A.; Bleecker, Eugene R.
This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function,