WorldWideScience

Sample records for susan gussenhoven-shea dr

  1. Dedication - Susan L Greenblatt

    Science.gov (United States)

    Guberman, Steven L.

    2011-07-01

    Photo of Susan L Greenblatt Figure 1. Susan in May, 1994 This volume is dedicated to the memory of Susan L Greenblatt, the wife of Steven L Guberman. Susan attended 6 of the 8 dissociative recombination (DR) meetings. Her advice and wise counsel played a vital role in the organization of several of these meetings. The fifth meeting in Chicago in 2001 was her idea and it would not have occurred without her encouragement. Susan was always amused by the memory of the first group dinner at the second DR meeting at St Jacut in 1992. As we went around the dinner table identifying ourselves, it soon became her turn. Susan was a sociologist and after introducing herself she said: "I am not a chemist". A spontaneous chorus of attendees proclaimed "Neither are we!". Her husband and a few other chemists abstained. In 1983, Susan and I established the Institute for Scientific Research (ISR). The name was chosen so as to span sociology and chemical physics. Four years prior, an ophthalmologist had diagnosed a rare retinal condition of unknown origin and advised her to change her profession to one that did not involve reading. (She was able to read for the rest of her life.) Twenty years later we learned that the cause of the retinal and all her other health problems was a recently discovered rare mitochondrial mutation. Her experience with ophthalmologists and her life-long keen sense of injustice, led her to write a grant proposal to the US Department of Education to survey all ophthalmologists in the US to determine whether they were aware of and whether they told their patients about resources and aids that could help them to continue reading and participating in everyday activities. As part of the grant and based upon the survey results, she proposed to set up low-vision training programs for ophthalmology residents. We knew that the competition for funding was intense and included several well-known and more established organizations. Nevertheless, the proposal was funded

  2. Susan Smith

    African Journals Online (AJOL)

    Owner

    Soveel lesers soveel lokmiddele soveel re- sponse kan gelys word om toegang tot die lees van poësie te registreer. 'n Resep om ge- trou of in ontrou na te volg, bestaan nie. Ge- lukkig nie. Susan Smith se (debuut)bundel lok my helaas nie deur die voorblad as vertrek- punt te neem nie. Aan visuele prikkelkrag gaan.

  3. Susan Flannery lahkub? / Harro Puusild

    Index Scriptorium Estoniae

    Puusild, Harro

    2008-01-01

    Ameerika teleseriaali "Vaprad ja ilusad" Stephanie Forresteri osatäitja Susan Flannery (1943) on seriaalis mänginud algusest peale s.o. 21 aastat. Lisatud intervjuu näitlejatariga. Sama ka Teleleht nr. 15, lk. 8-9 : ill

  4. In Conversation with Susan Holtz | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-11-26

    Nov 26, 2010 ... Susan Holtz is a private consultant and Adjunct Professor in the Environmental Planning Department of the Nova Scotia College for Art and Design. As a consultant, Ms. Holtz specializes in energy, environment, and sustainable development policy, and works on related issues as a mediator and facilitator.

  5. Roberts, Dennis C. & Komives, Susan R.

    African Journals Online (AJOL)

    Enhancing Student Learning and Development in Cross-Border Higher Education, edited by. Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation's Education City in Doha in 2010.

  6. Design package lazy susan for the fuel retrieval system

    Energy Technology Data Exchange (ETDEWEB)

    TEDESCHI, D.J.

    1999-09-10

    This is a design package that contains the details for a Lazy Susan style small tool for the Fuel Retrieval System. The Lazy Susan tool is used to help rotate an MCO Fuel Basket when loading it. This document contains requirements, development design information, tests and test reports that pertain to the production of Lazy Susan small tool.

  7. Psychoanalytic Interpretation of Blueberries by Susan Gibb

    OpenAIRE

    Zalbidea Paniagua, Maya

    2014-01-01

    [ES] La obra de ficción digital titulada Blueberries (2009) de Susan Gibb, publicada en la ELO (Organización de literatura electrónica) invita al lector/a a viajar dentro de la mente de la protagonista para descubrir sus experiencias reales e imaginarias en las que se examinan las nociones de género, sexo, cuerpo e identidad de una mujer traumatizada. En este artículo se exploran los modos verbales y visuales en esta ficción digital breve siguiendo patrones semióticos así como se interpretan ...

  8. 75 FR 38837 - Susan Harwood Training Grant Program, FY 2010

    Science.gov (United States)

    2010-07-06

    ...: Notification of Funding Opportunity for Susan Harwood Training Grant Program, FY 2010. Funding Opportunity No... project performance period is $250,000. DATES: Targeted Topic training grant applications must be received... Links section, and then select ``Susan Harwood Training Grant Program''. Please note that on the Harwood...

  9. Susan Lindquist: Visionary scientist and peerless mentor.

    Science.gov (United States)

    Bevis, Brooke J

    2017-01-02

    The science universe is dimmer after one of our brightest stars, Susan Lee Lindquist, was taken by cancer on October 27, 2016. Sue was an innovative, creative, out-of-the-box scientific thinker. She had unique biological intuition-an instinct for both the way things worked and the right questions to ask to uncover new research insights. Her wide-ranging career began with the study of protein folding and molecular chaperones, and she went on to show that protein folding can have profound and unexpected biological effects on such diverse processes as cancer, evolution, and neurodegenerative disease. As Sue's laboratory manager, I would like to offer a ground-floor perspective on what made her an exceptional scientist, mentor, and leader. She created a harmonious, collegial environment where collaborative synergy fueled meaningful progress that will impact science for decades to come. © 2017 Bevis.

  10. Psychoanalytic Interpretation of Blueberries by Susan Gibb

    Directory of Open Access Journals (Sweden)

    Maya Zalbidea Paniagua

    2014-06-01

    Full Text Available Blueberries (2009 by Susan Gibb, published in the ELO (Electronic Literature Organization, invites the reader to travel inside the protagonist’s mind to discover real and imaginary experiences examining notions of gender, sex, body and identity of a traumatised woman. This article explores the verbal and visual modes in this digital short fiction following semiotic patterns as well as interpreting the psychological states that are expressed through poetical and technological components. A comparative study of the consequences of trauma in the protagonist will be developed including psychoanalytic theories by Sigmund Freud, Jacques Lacan and the feminist psychoanalysts: Melanie Klein and Bracha Ettinger. The reactions of the protagonist will be studied: loss of reality, hallucinations and Electra Complex, as well as the rise of defence mechanisms and her use of the artistic creativity as a healing therapy. The interactivity of the hypermedia, multiple paths and endings will be analyzed as a literary strategy that increases the reader’s capacity of empathizing with the speaker.

  11. Susan Sontag — A Forgotten Mother?

    Directory of Open Access Journals (Sweden)

    Kludia Ziewiec

    2013-01-01

    Full Text Available The article discusses new and republished translations of Susan Sontag’s work, recently launched by the Karakter publishing house: Regarding the Pan of Others, On Photography, and Against Interpretation and Other Essays. The article focuses on the elements of Sontag’s thought that make her a forgotten mother of feminist and gender theoreticians, as well as such influential critics as Michel Foucault and Roland Barthes. The article points out to continuations of Sontag’s thought in contemporary theoretical and social projects, and to the pertinence of her critical observations on theories based on metaphysics of presence: psychoanalysis, Marxism, or hermeneutics. The article also touches upon history of war photography and related war journalism, and upon the ambivalent quality of imaging of the misery of war. It also present historical and cultural circumstances of the development of Sontag’s thought in the intellectual milieu of New York in the 1960s. The discussion recapitulates the main statements of Sontag’s essays, relating them to a wider theoretical context, which is aimed at a reappraisal of the forgotten intelectual in the history of literature.

  12. Meet EPA Scientist Susan Yee, Ph.D.

    Science.gov (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  13. Susan swan and the female grotesque Susan swan and the female grotesque

    Directory of Open Access Journals (Sweden)

    Suzana Bornéo Funck

    2008-04-01

    Full Text Available Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics. Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics.

  14. Collaborative Internet Projects: An Interview with Susan Silverman about Her Passion and Hobby.

    Science.gov (United States)

    Strangman, Nicole

    2002-01-01

    Outlines an interview with Susan Silverman, an instructional technology integration teacher in the Comsewogue school district in Port Jefferson Station, New York. Describes Susan's transformation from technophobe to an innovator of collaborative Internet projects. (PM)

  15. Susan Dicklitch. The Elusive Promise of NGO's | Heck | Uganda ...

    African Journals Online (AJOL)

    Susan Dicklitch. The Elusive Promise of NGO's. Simon Heck. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/uj.v46i1.23044 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  16. Unwrapping the Thick Coat of Armor: A Conversation with Susan Albrecht

    Science.gov (United States)

    Kaff, Marilyn; Teagarden, Jim; Zabel, Robert

    2017-01-01

    Susan Albrecht's career has spanned more than 40 years. During those years she has served as an English teacher, school psychologist, behavior consultant, coordinator of services, and special education faculty member. Her contributions to the field include leadership positions with the Council for Children with Behavioral Disorders. Susan shared…

  17. Practitioner Profile: An Interview with Susan Bross, AFC®

    Directory of Open Access Journals (Sweden)

    Susan Bross

    2011-04-01

    Full Text Available

    Susan Bross is a nationally accredited financial counselor who established her private practice in 1992. She currently lives in San Rafael, California. She brings a multi-faceted background and a combination of skills to her work. As a financial counselor, she works with individuals, couples, and entrepreneurs throughout the nation to help clients develop a practical and emotionally healthy relationship with money. When asked, she will tell you that she is passionate about her work because it mirrors her own hard-won path with money. Readers of the Journal will find Ms. Bross’s approach to financial therapy inspiring. She teaches simple tools for effortless and sustainable cash flow and money management. She also guides her clients to balanced attitudes and beliefs about money and success.

  18. [The Durkheim Test. Remarks on Susan Leigh Star's Boundary Objects].

    Science.gov (United States)

    Gießmann, Sebastian

    2015-09-01

    The article reconstructs Susan Leigh Star's conceptual work on the notion of 'boundary objects'. It traces the emergence of the concept, beginning with her PhD thesis and its publication as Regions of the Mind in 1989. 'Boundary objects' attempt to represent the distributed, multifold nature of scientific work and its mediations between different 'social worlds'. Being addressed to several 'communities of practice', the term responded to questions from Distributed Artificial Intelligence in Computer Science, Workplace Studies and Computer Supported Cooperative Work (CSCW), and microhistorical approaches inside the growing Science and Technology Studies. Yet the interdisciplinary character and interpretive flexibility of Star’s invention has rarely been noticed as a conceptual tool for media theory. I therefore propose to reconsider Star's 'Durkheim test' for sociotechnical media practices.

  19. Susan J. Quaal: the global and local impact of a transformational leader.

    Science.gov (United States)

    Finlay, L D

    1998-01-01

    To be a transformational leader in nursing, one must have forever changed the course of our practice. This article highlights the qualities of a great leader, Susan J. Quaal, PhD, APRN, CVS, CCRN. Described are examples of Susan's incredible clinical expertise and also the attributes that make her such a dynamic leader in all domains of the clinical nurse specialist role: Practitioner, educator/mentor, consultant, leader/administrator, and researcher. Interwoven in this article, you will also find the threads of humility and charity that make Susan such an extraordinary human being and a blessing to all the lives she touches.

  20. Textual Rhetorics and Textual Carnivals: Susan Miller and the "Subjects" of Rhetoric and Composition.

    Science.gov (United States)

    Reynolds, Nedra

    1991-01-01

    Reviews two books by Susan Miller: "Rescuing the Subject: A Critical Introduction to Rhetoric and the Writer" (1989) and "Textual Carnivals: The Politics of Composition" (1991). Notes how she rereads dominant histories of rhetoric and writing instruction, argues for a theory of textuality, and illustrates how attention to…

  1. Don't Take Touch for Granted: An Interview with Susan Lederman.

    Science.gov (United States)

    Verry, Rene

    1998-01-01

    Presents an interview with Susan Lederman that contains a fascinating and informative overview of the recent developments in neuropsychological research concerning the sense of touch. Discusses the physiological processes that support this sensory experience and reveals them to be much more flexible, intricate, and adaptive than previously…

  2. Re-Establishing Social Studies as a Core Subject: An Interview with Susan Griffin

    Science.gov (United States)

    Griffin, Susan

    2014-01-01

    NCSS Executive Director Susan Griffin was chair of the Task Force of Professional Organizations that worked with the Social Studies Assessment, Curriculum, and Instruction Collaborative (SSACI) of the Council of Chief State School Officers to initiate and guide the development of the "College, Career and Civic Life (C3) Framework for Social…

  3. Teaching Students About Stereotypes, Prejudice, and Discrimination: An Interview with Susan Fiske

    Science.gov (United States)

    Hackney, Amy

    2005-01-01

    Susan T. Fiske is professor of psychology, Princeton University (PhD, Harvard University; honorary doctorate, Universite Catholique de Louvain-la-Neuve, Belgium). She wrote Social Cognition (with Taylor) on how people make sense of each other. Currently, she investigates emotional prejudices (pity, contempt, envy, and pride) at cultural,…

  4. Inside the Sex Ed Studio: An Interview with Susan N. Wilson

    Science.gov (United States)

    Taverner, William J.

    2007-01-01

    "Inside the Sex Ed Studio" profiles leaders in the field of sexuality education. Susan N. Wilson, former Executive Coordinator of the Network for Family Life Education, long-time advocate for sexuality education, and the driving force behind New Jersey's K-12 mandate for comprehensive sexuality education was the first such leader to be…

  5. Large Customers (DR Sellers)

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccot, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  6. Drømmejobbet

    DEFF Research Database (Denmark)

    Harrebye, Silas

    2012-01-01

    Medarbejdere vil i fremtiden også kunne arbejde, mens de sover. Virksomheder tilbyder snart deres ansatte interne kurser i ‘lucid dreaming’. Disse giver mulighed for, at man i sine drømme bliver bevidst om, at man drømmer og således kan manipulere dem. Det skal nu udnyttes. Management...

  7. Dr. Dampe - Doctor Democracy

    DEFF Research Database (Denmark)

    Andreasen, John

    2009-01-01

    On Dr.phil. J.J.Dampe's fight for democracy in the first part of the 19th century in Denmark and his dramatic writings......On Dr.phil. J.J.Dampe's fight for democracy in the first part of the 19th century in Denmark and his dramatic writings...

  8. Dr. Daniel Carter

    Science.gov (United States)

    1998-01-01

    Dr. Daniel Carter, president of New Century Pharmaceuticals in Huntsville, Al, is one of three principal investigators in NASA's microgravity protein crystal growth program. Dr. Carter's experties is in albumins. Albumins are proteins in the bloodstream that transport materials, drugs, nutrients, and wastes. Photo credit: NASA/Marshall Space Flight Center

  9. Visit of Dr. Stoltenberg

    CERN Multimedia

    CERN PhotoLab

    1966-01-01

    During a visit of Dr. Stoltenberg, Minister for Scientific Research of the Federal Republic of Germany (centre), Professor Paul explains a point, whilst standing by are (left to right) Dr. Schulte-Meermann, Chairman of the Finance Committee, professor Weisskopf, former Director-General, and professor Gregory Director-General.

  10. Obituary: Dr Dimitri Tassiopoulos

    African Journals Online (AJOL)

    2017-06-22

    Jun 22, 2017 ... closely together with Prof. Phaswana-Mafuya, managed to bring the journal under the Taylor & Francis Online stable with Routledge. Press. SAHARAJ's impact factor has risen during his leadership. Dr Tassiopoulos also managed the SAHARA Conference. Dr Tassiopoulos was involved in collaborating in ...

  11. Galande, Dr Sanjeev

    Indian Academy of Sciences (India)

    Elected: 2010 Section: General Biology. Galande, Dr Sanjeev Ph.D. (IISc). Date of birth: 20 September 1967. Specialization: Epigenetics, Chromatin Biology, Gene Regulation, Genomics and Proteomics Address: Centre for Excellence in Epigenetics, Indian Institute of Science Education, & Research, Dr Homi Bhabha Road, ...

  12. The DR-2 project

    DEFF Research Database (Denmark)

    Ølgaard, Povl Lebeck

    2003-01-01

    DR-2 was a 5 MW tank type, water moderated and cooled research reactor, which was operated at the Risø National Laboratory from 1959 to 1975. After the close-down in1975 the DR-2 has been kept in safe enclosure until now. The aim of the DR-2 projectreported here was to characterize the present...... their activity had been measured. The activity of the radiation shield of the reactor was measured in three different ways: By drilling two cored holes through the shield, by thermo-luminescence dosimeter measurements in vertical tubes in theconcrete shield and by measurements through an open beam hole...

  13. Gopinath, Dr Chinnakonda Subramanian

    Indian Academy of Sciences (India)

    Gopinath, Dr Chinnakonda Subramanian Ph.D. (IIT, Madras). Date of birth: 4 June 1964. Specialization: Water Splitting, Materials Science, Surface Science, Heterogeneous Catalysis, Spectroscopy Address: Senior Principal Scientist, Catalysis Division, National Chemical Laboratory, Pune 411 008, Maharashtra Contact:

  14. Deshpande, Dr A A

    Indian Academy of Sciences (India)

    Period: 1989–1993. Deshpande, Dr A A . Date of birth: 23 January 1958. Specialization: Observational Radio Astronomy Address during Associateship: Raman Research Institute, C.V. Raman Avenue, Sadashivanagar P.O, Bangalore 560 080.

  15. Nair, Dr Gopalan Vijayakumaran

    Indian Academy of Sciences (India)

    Nair, Dr Gopalan Vijayakumaran Ph.D. (Banaras and British Columbia). Date of birth: 5 October 1941. Specialization: Synthetic Organic Chemistry, Heterocyclic Chemistry , Organocatalysis Address: Honorary Scientist, National Institute for Interdisciplinary Science &, Technology, Thiruvananthapuram 695 019, Kerala

  16. Thiagarajan, Dr Pazhamaneri Subramaniam

    Indian Academy of Sciences (India)

    Elected: 1995 Section: Mathematical Sciences. Thiagarajan, Dr Pazhamaneri Subramaniam Ph.D. (Rice), FNASc. Date of birth: 9 November 1948. Specialization: Distributed Probabilistic Systems, Hybrid Systems and Computational Systems Biology Address: Laboratory of System Pharmacology, Harvard Medical School, ...

  17. Nadkarni, Dr Vikas Madhusudan

    Indian Academy of Sciences (India)

    Elected: 1993 Section: Engineering & Technology. Nadkarni, Dr Vikas Madhusudan Ph.D. (Delaware). Date of birth: 6 December 1947. Specialization: Polymer Science & Engineering, Materials Science and Chemical Engineering Address: Managing Director, Techcellence Consultancy Services, Pvt. Ltd., 5, Pushkaraj, ...

  18. Balasubramanian, Dr Kalpattu Kuppusamy

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1991 Section: Chemistry. Balasubramanian, Dr Kalpattu Kuppusamy Ph.D. (Madras), FNA. Date of birth: 5 September 1939. Specialization: Molecular Rearrangements, Carbohydrate Chemistry, Organic Electrophotochemistry, Synthetic Organic Chemistry and Heterocyclic Chemistry Address: No.

  19. Mistry, Dr Kekshushroo Bamanshaw

    Indian Academy of Sciences (India)

    D. (Delhi). Date of birth: 13 January 1936. Specialization: Soil Science, Fertilizers and Agrochemicals Address: 52, Sunshine, Dr Rajaballi Patel Lane, Mumbai 400 026, Maharashtra Contact: Residence: (022) 2351 7387, (022) 2351 0564

  20. Happy Birthday, Dr. Seuss!

    Science.gov (United States)

    Brodie, Carolyn S.

    2002-01-01

    Reports on the career of Theodor Seuss Geisel and suggests activities to celebrate his birthday. Lists selected children's books by Dr. Seuss, selected Seuss videos, Web sites, biographical resources, and biographical videos. (LRW)

  1. Jayaraman, Dr Narayanaswamy

    Indian Academy of Sciences (India)

    Elected: 2011 Section: Chemistry. Jayaraman, Dr Narayanaswamy Ph.D. (IIT, Kanpur). Date of birth: 25 May 1964. Specialization: Carbohydrate Chemistry, Dendrimer Chemistry, Synthetic Organic Chemistry Address: Department of Organic Chemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  2. Davis, Dr Trupapur Antony

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1979 Section: Plant Sciences. Davis, Dr Trupapur Antony Ph.D. (ISI). Date of birth: 9 February 1923. Date of death: 10 November 1989. Specialization: Plant Physiology. YouTube; Twitter; Facebook; Blog ...

  3. "A hint of it, with initials": adultery, textuality and publicity in Jane Austen's Lady Susan.

    Science.gov (United States)

    Russell, Gillian

    2010-01-01

    In spite of Jane Austen's professed “eye” for an adulteress, comparatively little attention has been paid to adultery and divorce as themes and contexts of her fiction. Her unpublished epistolary novel Lady Susan has a distinctive status in Austen's oeuvre, recognized as being exemplary of her “style” and yet atypical of her later achievement. A neglected context for the novel is the extensive reporting of adultery trials in contemporary print culture and the moral panic concerning adultery in the 1780s and 1790s, focusing initially on the adulteress as the brazen woman of fashion and later as a figure of sentimentalized abjection. A particularly notorious case, that involving Lady Henrietta Grosvenor and George III's brother, the Duke of Cumberland, is directly alluded to in Lady Susan. The textual strategies of adultery trial literature, particularly its emphasis on indirection through the use of detail or “hint”, had a long-term influence on the development of Austen's fiction and her positioning of herself as a professional writer after the 1790s.

  4. Amritkar, Dr Ravindra Eknath

    Indian Academy of Sciences (India)

    Amritkar, Dr Ravindra Eknath Ph.D. (Bangalore), FNASc. Date of birth: 19 August 1951. Specialization: Nonlinear Phenomena, Chaos and Statistical Physics Address: Visiting Professor, Institute of Infrastructure, Technology, Research, and Management (IITRAM), Near Khokhara Circle, Ahmedabad 380 026, Gujarat Contact ...

  5. Anil, Dr Arga Chandrashekar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2015 Section: Earth & Planetary Sciences. Anil, Dr Arga Chandrashekar Ph.D. (Karnatak). Date of birth: 23 January 1959. Specialization: Biological Oceanography, Marine Ecology, Marine Biology Address: Chief Scientist, National Institute of Oceanography, Dona Paula 403 004, ...

  6. Chandrasekaran, Dr Chidambara

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1945 Section: Mathematical Sciences. Chandrasekaran, Dr Chidambara Ph.D. (London) 1962-64. Date of birth: 30 October 1911. Date of death: 4 January 2000. Specialization: Statistics, Public Health and Demography Address: 'Sri Kripa', 79/3, Benson Cross Road, Bengaluru ...

  7. Basu, Dr Sandip Kumar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1992 Section: General Biology. Basu, Dr Sandip Kumar Ph.D. (Calcutta), FNASc, FNA, FTWAS Council Service: 1995-97. Date of birth: 1 January 1944. Specialization: Cell Biology, Molecular Biology and Microbial Genetics Address: FD-426, Sector 3, Bidhan Nagar, Kolkata 700 106, W.B.. Contact:

  8. Shivanna, Dr Kundaranahalli Ramalingaiah

    Indian Academy of Sciences (India)

    Elected: 1985 Section: Plant Sciences. Shivanna, Dr Kundaranahalli Ramalingaiah Ph.D. (Delhi), FNA, FNAAS, FNASc. Date of birth: 30 June 1940. Specialization: Pollen Biology, Reproductive Ecology and Conservation Biology Address: Odekar Farms, Nandihalli, via Thovinakere, Tumkur 572 138, Karnataka Contact:

  9. Sengupta, Dr Sagar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2017 Section: General Biology. Sengupta, Dr Sagar Ph.D. (IISc), FNA, FNASc. Date of birth: 23 June 1968. Specialization: Cancer Biology, Cell Signalling, Mytochondrial Biology Address: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, U.T.. Contact: Office: (011) 2670 3786

  10. Sharma, Dr Ram Swaroop

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1989 Section: Earth & Planetary Sciences. Sharma, Dr Ram Swaroop Ph.D. (Basel), FNA. Date of birth: 10 July 1937. Specialization: Metamorphic Petrology, Mineralogy and Precambrian Geology Address: 70/36, Pratapnagar, Sector 7, Sanganer (RHB), Jaipur 302 033, Rajasthan

  11. Godwal, Dr Budhiram Kulanand

    Indian Academy of Sciences (India)

    Godwal, Dr Budhiram Kulanand Ph.D. (Bombay), FNASc. Date of birth: 8 February 1946. Specialization: Planetary Sciences, High Pressure Physics, Electron States and Dense Plasma Physics Address: 28, Creekview Co-operative Housing Society, Plot No. 33, Sector 9A, Vashi, Navi Mumbai 400 703, Maharashtra Contact:

  12. Brahmayya Sastry, Dr Podila

    Indian Academy of Sciences (India)

    Elected: 1978 Section: Medicine. Brahmayya Sastry, Dr Podila Ph.D. (McGill). Date of birth: 24 May 1913. Date of death: 28 May 1993. Specialization: Physiology, Neurophysiology and Placental Physiology Last known address: Sitaramanilayam, Plot No. 9, Doctors Co-Operative Housing Colony, Waltair, Visakhapatnam ...

  13. Gangal, Dr Sudha Gajanan

    Indian Academy of Sciences (India)

    Gangal, Dr Sudha Gajanan Ph.D. (Mumbai), FNA Council Service: 1995-97. Date of birth: 25 August 1934. Specialization: Cancer & Basic Immunology, Cell Biology and Genetic Diseases Address: 4, Mahavishnu Apartments, Dahanukar Colony A, Kothrud, Pune 411 029, Maharashtra Contact: Residence: (020) 2538 4382, ...

  14. Shetye, Dr Satish Ramnath

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1992 Section: Earth & Planetary Sciences. Shetye, Dr Satish Ramnath Ph.D. (Washington), FNA, FNASc. Council Service: 1998-2003. Date of birth: 25 October 1950. Specialization: Physical Oceanography Address: Yashoda, C-14/162, Tonca, Caranzalem, Panaji 403 002, Goa

  15. Gupta, Dr Pradeep Kumar

    Indian Academy of Sciences (India)

    Elected: 2007 Section: Physics. Gupta, Dr Pradeep Kumar Ph.D. (Heriot Watt University), FNASc. Date of birth: 16 August 1954. Specialization: Lasers, Biomedical Applications of Lasers, Nonlinear Optics, Laser Materials Address: Visiting Professor, Department of Physics, Indian Institute of Technology, New Delhi 110 016, ...

  16. Jena, Dr Prafulla Kumar

    Indian Academy of Sciences (India)

    Jena, Dr Prafulla Kumar Ph.D. (Utkal). Date of birth: 27 December 1931. Specialization: Extractive Metallurgy, Mineral Processing, Environmental Engineering and Materials Processing Address: Chairman, Institute of Advance Technology and Environmental Studies, 80A-831A Lewis Road, Bhubaneswar 751 002, Orissa

  17. Krishnan, Dr Raghavan

    Indian Academy of Sciences (India)

    Specialization: Monsoon & Climate Dynamics, Atmosphere-Ocean-Land System, Monsoon Hydrological Cycle Address: Acting Director, Indian Institute of Tropical Meteorology, Dr Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra Contact: Office: (020) 2590 4301. Residence: (020) 2589 8886. Mobile: 98817 37976

  18. Kulkarni, Dr Mohan Gopalkrishna

    Indian Academy of Sciences (India)

    Elected: 1996 Section: Engineering & Technology. Kulkarni, Dr Mohan Gopalkrishna Ph.D. (Mumbai), FNAE. Date of birth: 14 November 1950. Specialization: Polymer Science & Engineering, Intellectual Property Address: Emeritus Scientist, Unit for R&D of Information Products, Tapovan, NCL Campus, Pashan Road, Pune ...

  19. Bhawalkar, Dr Dilip Devidas

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1986 Section: Physics. Bhawalkar, Dr Dilip Devidas Ph.D. (Southampton), FNA, FNASc. Date of birth: 16 October 1940. Specialization: Lasers and laser Instrumentation Address: 26, Paramanu Nagar, Indore 452 013, M.P.. Contact: Office: (0731) 232 2707. Residence: (0731) 232 0031. Mobile: 93032 ...

  20. Authikesavalu, Dr Munisamy

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1948 Section: Medicine. Authikesavalu, Dr Munisamy MBBS (Madras), MS (Minneapolis), FRCS. Date of birth: 16 August 1906. Date of death: 22 September 1973. Specialization: Experimental Surgery, Ophthalmology, Otolaryngology Address: 5-C, Lavelle Cross Road, Bengaluru ...

  1. Amarjit Singh, Dr

    Indian Academy of Sciences (India)

    Amarjit Singh, Dr Ph.D. (Harvard). Date of birth: 19 November 1924. Specialization: Millimeter Wave Tubes, Microwave Tubes and Microwave Electronics Address: 12, Auburn Court, Vernon Hills, IL 60061, USA Contact: Residence: (+1-847) 247 9260. Email: amarjitsingh@ieee.org. YouTube; Twitter; Facebook; Blog ...

  2. Agnihothrudu, Dr Vengala

    Indian Academy of Sciences (India)

    Agnihothrudu, Dr Vengala Ph.D. (Madras). Date of birth: 15 May 1930. Date of death: 5 April 1999. Specialization: Microbiology, Plant Pathology, Agrochemicals, Plantation Crops and Environmental Hygiene Last known address: 18/1, First Cross, First Main, Jayamahal Extension, Bengaluru 560 016. YouTube; Twitter ...

  3. David, Dr Joy Caesarina

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1982 Section: Medicine. David, Dr Joy Caesarina M.B.B.S., M.S. (Madras). Date of birth: 3 May 1927. Date of death: 20 April 2004. Specialization: Neuropharmacology Last known address: 292, 4th Main, 1st Block, Koramangala, Bengaluru 560 034. YouTube; Twitter; Facebook ...

  4. Arankalle, Dr Vidya Avinash

    Indian Academy of Sciences (India)

    Elected: 2010 Section: Medicine. Arankalle, Dr Vidya Avinash Ph.D. (Bombay), FNA. Date of birth: 2 February 1952. Specialization: Virology, Molecular Biology, Vaccine, Hepatitis Viruses, Emerging-Reemerging Viruses Address: IRSHA, Bharati Vidyapeeth University, Katraj, Pune 411 043, Maharashtra Contact:

  5. Chattopadhyay, Dr Dhrubajyoti

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2004 Section: General Biology. Chattopadhyay, Dr Dhrubajyoti Ph.D. (Calcutta), FNASc. Date of birth: 11 May 1954. Specialization: Enzyme Biotechnology, Transcription, Molecular Virology and Oxidative Stress Response Address: Vice Chancellor, Amity University, New Town, Kolkata 700 135, W.B.

  6. Datta, Dr Alok Kumar

    Indian Academy of Sciences (India)

    Elected: 1996 Section: General Biology. Datta, Dr Alok Kumar Ph.D. (Calcutta), FNA. Date of birth: 10 November 1946. Specialization: Nucleic Acid Enzymology, Protein Chemistry, Parasitology and Recombinant DNA Technology Address: INSA Senior Scientist, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, ...

  7. Chaudhuri, Dr Swetaprovo

    Indian Academy of Sciences (India)

    Home; Fellowship; Associateship. Associate Profile. Period: 2016–2019. Chaudhuri, Dr Swetaprovo Ph.D. (Connecticut). Date of birth: 1 September 1983. Specialization: Propulsion,Turbulent Combustion, Energy Address: Dept. of Aerospace Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  8. Arunachalam, Dr Vallampadugai Srinivasaraghavan

    Indian Academy of Sciences (India)

    Elected: 1979 Section: Engineering & Technology. Arunachalam, Dr Vallampadugai Srinivasaraghavan Ph.D. (Wales), F.R.Engg. (UK), FNA, FNASc, FNAE, D.Engg. (h.c.), D.Litt. (h.c.) Council Service: 1983-85. Date of birth: 10 November 1935. Specialization: Materials Science & Engineering, Energy Technologies, ...

  9. Mohan, Dr Viswanathan

    Indian Academy of Sciences (India)

    Ph.D. (Madras), FNASc, FNA, FRCP (London, Glasgow, Edinburgh, Ireland), FTWAS. Date of birth: 10 April 1954. Specialization: Diabetes and its Complications, Epidemiology, Genomic Studies Address: Dr Mohan's Diabetes Specialities Centre, No. 6B, Conran Smith Road, Gopalapuram, Chennai 600 086, T.N.. Contact:

  10. Gore, Dr Anil Purushottam

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1997 Section: Animal Sciences. Gore, Dr Anil Purushottam Ph.D. (Kentucky). Date of birth: 10 August 1947. Specialization: Analysis of Clinical Trials, Non-parametric Inference and Statistical Ecology Address: Bakul, 40, Empress Garden Society, Sopan Baug, Pune 411 001, Maharashtra Contact:

  11. Gurjar, Dr Mukund Keshao

    Indian Academy of Sciences (India)

    Gurjar, Dr Mukund Keshao Ph.D. (Nagpur and London), FNASc. Date of birth: 28 August 1952. Specialization: Carbohydrate Chemistry and Synthetic Organic Chemistry Address: Director, R&D, Emcure Pharmaceuticals Limited, P2, ITBT Park Phase II, Hinjwadi, Pune 411 057, Maharashtra Contact: Office: (020) 3982 1350, ...

  12. Bhisey, Dr Rajani Avinash

    Indian Academy of Sciences (India)

    ... Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1996 Section: Medicine. Bhisey, Dr Rajani Avinash Ph.D. (Mumbai), FNA. Date of birth: 20 January 1941. Specialization: Environmental Carcinogenesis and Molecular Epidemiology of Cancer, Occupational Hazards

  13. Mishra, Dr Gyan Chandra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2005 Section: General Biology. Mishra, Dr Gyan Chandra Ph.D. (Udaipur), FNASc, FNA. Date of birth: 15 August 1947. Specialization: Immunology and Cell Biology Address: NASI Senior Scientist, National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune 411 007, Maharashtra Contact:

  14. Khanna, Dr Navin Chandra

    Indian Academy of Sciences (India)

    Elected: 2017 Section: Medicine. Khanna, Dr Navin Chandra Ph.D. (AIIMS), FNASc. Date of birth: 1 April 1956. Specialization: Dengue Subunit Vaccine, Dengue Botanical Drug, Recombinant Proteins of Medical Use Address: International Centre for Genetic Engineering, and Biotechnology, Aruna Asaf Ali Marg, New Delhi ...

  15. Mahalakshmi, Dr Radhakrishnan

    Indian Academy of Sciences (India)

    Mahalakshmi, Dr Radhakrishnan Ph.D. (IISc). Date of birth: 8 April 1980. Specialization: Membrane Protein Biophysics, Protein Folding, Spectroscopy Address during Associateship: MBL, Dept. of Biological Sci., Indian Institute of Science Edn. &, Research, Bhauri, Bhopal 462 066, M.P.. Contact: Office: (0755) 669 2562

  16. Dasgupta, Dr Somnath

    Indian Academy of Sciences (India)

    Dasgupta, Dr Somnath Ph.D. (Jadavpur), FNA, FNASc, FTWAS. Date of birth: 13 October 1951. Specialization: Metamorphic Petrology, Geochemistry and Precambrian Geology Address: Chair Professor, Department of Geography, Faculty of Natural Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, U.T.

  17. Sharma, Dr Surendra Kumar

    Indian Academy of Sciences (India)

    Elected: 2010 Section: Medicine. Sharma, Dr Surendra Kumar Ph.D. (AIIMS), MD (PGIMER, Chandigarh), FNASc, FNA. Date of birth: 22 February 1951. Specialization: Environmental Medicine, Infectious Diseases, Internal Medicine, Pulmonary & Critical Care and Sleep Medicine Address: B-5/3, B Block, Sector 13, RK ...

  18. Mukerji, Dr Mitali

    Indian Academy of Sciences (India)

    Elected: 2014 Section: Medicine. Mukerji, Dr Mitali Ph.D. (IISc). Date of birth: 13 November 1967. Specialization: Functional Genomics, Population Genomics, Ayurgenomics Address: Sr Principal Scientist, Genomics & Molecualr Medicine, Institute of Genomics & Integrative Biology, Sukhdev Vihar, Mathura Road, New Delhi ...

  19. Ramaiah, Dr Danaboyina

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2010 Section: Chemistry. Ramaiah, Dr Danaboyina Ph.D. (IIT, Kanpur), FNASc. Date of birth: 4 June 1958. Specialization: Bio-organic Chemistry, Photobiology, Biophysical Chemistry, Organic Photochemistry Address: Director, North East Institute of Science & Technology, Jorhat 785 006, Assam

  20. Venkateswara Rao, Dr Gundabathula

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2003 Section: Engineering & Technology. Venkateswara Rao, Dr Gundabathula Ph.D. (IISc), FNAE. Date of birth: 9 November 1944. Specialization: Finite Element Methods, Structural Analysis (Linear & Nonlinear) and Smart Structures Address: No. 502, Reliance Mariam Villa, Street No. 6, Plot No.

  1. Ramachandran, Dr Sundaresan

    Indian Academy of Sciences (India)

    Elected: 1974 Section: Engineering & Technology. Ramachandran, Dr Sundaresan D.Sc. (MIT). Date of birth: 17 August 1930. Specialization: Alloy & Stainless Steel Making and Process Metallurgical Design & Development Address: 'Vidya Theertha Kripa', No. 1, Siva Sundar Avenue, Thiruvanmiyur, Chennai 600 041, T.N.

  2. Sirsat, Dr Satyavati Motiram

    Indian Academy of Sciences (India)

    Sirsat, Dr Satyavati Motiram Ph.D. (Mumbai). Date of birth: 7 October 1925. Date of death: 10 July 2010. Specialization: Medical Research (Cancer) & Ultrastructural Pathology and Hospice Care of the Dying Last known address: Bhagirathi Sadan, 17th Road, Khar, Mumbai 400 052. YouTube; Twitter; Facebook; Blog ...

  3. Paranjape, Dr Aseem

    Indian Academy of Sciences (India)

    Associate Profile. Period: 2015–2018. Paranjape, Dr Aseem Ph.D. (TIFR). Date of birth: 26 January 1983. Specialization: Cosmology, Large Scale Structure, Gravitation Address: Inter-University Centre for, Astronomy & Astrophysics, Ganeshkhind, Pune 411 007, Maharashtra Contact: Office: (020) 2560 4100, 2560 4224

  4. Pal, Dr Gaya Prasad

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1994 Section: Medicine. Pal, Dr Gaya Prasad M.B.B.S. and M.S. (Indore), D.Sc. (S. Gujarat), FNASc, FAMS. Date of birth: 7 June 1950. Specialization: Human Anatomy, Clinical Anatomy and Biomechanics of Spine Address: FASI Director, Modern Institute of Medical Sciences, Kanadia, Near Bypass ...

  5. Mukhopadhyay, Dr Sangita

    Indian Academy of Sciences (India)

    Elected: 2013 Section: Medicine. Mukhopadhyay, Dr Sangita Ph.D. (Utkal), FNASc. Date of birth: 1 January 1966. Specialization: Immunology, Cell Signalling, Communicable Diseases Address: Group Leader, Molecular Cell Biology, Centre for DNA Fingerprinting & Diagnostics, Nampally, Hyderabad 500 001, A.P.. Contact ...

  6. Nayak, Dr Tapan Kumar

    Indian Academy of Sciences (India)

    Nayak, Dr Tapan Kumar Ph.D. (Michigan State), FNASc. Date of birth: 18 June 1958. Specialization: Nuclear & High Energy Physics Experiment, QCD Phase Transition & Quark, Gluon Plasma, Phases of Nuclear Matter Address: Head, EHEP Division, Variable Energy Cyclotron Centre, 1/AF, Bidhan Nagar, Kolkata 700 064, ...

  7. Jameel, Dr Shahid

    Indian Academy of Sciences (India)

    Jameel, Dr Shahid Ph.D. (Washington State Univ.), FNASc, FNA. Date of birth: 8 August 1957. Specialization: Molecular Biology and Molecular Virology Address: Chief Executive Officer, The Wellcome Trust/DBT India Alliance, 8-2-684/3/K/19, Kaushik Society, Road NO. 12, Banjara Hills, Hyderabad 500 034, A.P.. Contact:

  8. Chopra, Dr Ishwar Chander

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1962 Section: Medicine. Chopra, Dr Ishwar Chander M.R.C.S.. Date of birth: 8 January 1911. Date of death: 18 October 1996. Specialization: Pharmacology, Toxicology and Indian Medicinal Plants Last known address: C-116, Defence Colony, New Delhi 110 024. YouTube; Twitter; Facebook; Blog ...

  9. Chakraborty, Dr Subhra

    Indian Academy of Sciences (India)

    Chakraborty, Dr Subhra Ph.D. (JNU). Date of birth: 25 September 1964. Specialization: Nutritional & Stress Genomics, Plant proteomics, Molecular Biology, Biotechnology Address: Staff Scientist VII, National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110 067, U.T.. Contact: Office: (011) 2673 5186

  10. Babu, Dr Cherukuri Raghavendra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1990 Section: Plant Sciences. Babu, Dr Cherukuri Raghavendra D.Phil. (Calcutta). Date of birth: 30 June 1940. Specialization: Biosystematics, Ecology and Population Genetics Address: Professor Emeritus, CEMDE, School of Environmental Studies, University of Delhi, Delhi 110 007, U.T.. Contact:

  11. Nair, Dr Gopinath Balakrish

    Indian Academy of Sciences (India)

    Nair, Dr Gopinath Balakrish Ph.D. (Annamalai), FNA, FNASc, FTWAS. Date of birth: 5 January 1954. Specialization: Clinical Microbiology, Molecular Epidemiology, Diarrhoeal Diseases Address: Ag. Regional Adviser, World Health Organisation, Mahatma Gandhi Marg, Indraprastha Estate, New Delhi 110 002, U.T.. Contact:

  12. Sethunathan, Dr Nambrattil

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1986 Section: Plant Sciences. Sethunathan, Dr Nambrattil Ph.D. (Madras), FNA, FNAAS, FNASc. Date of birth: 2 June 1937. Specialization: Environmental Microbiology Address: Flat No. 103, Ushodaya Apartments, Sri Venkateswara Officers' Colony, Ramakrishnapuram, Secunderabad 500 056, A.P.

  13. Ranade, Dr Vivek Vinayak

    Indian Academy of Sciences (India)

    Ranade, Dr Vivek Vinayak Ph.D. (Mumbai), FNAE Council Service: 2016. Date of birth: 15 October 1963. Specialization: Multiphase Flows & Reactors, Computational Flow Modelling, Process Intensification Address: School of Chemistry & Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, ...

  14. Bhattacharyya, Dr Suvendra Nath

    Indian Academy of Sciences (India)

    Elected: 2017 Section: General Biology. Bhattacharyya, Dr Suvendra Nath Ph.D. (Jadavpur), FNASc. Date of birth: 4 October 1975. Specialization: Molecular Biology, Cell Biology, RNA Biology Address: Molecular & Human Genetics Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata 700 032, ...

  15. Chandrasekharan, Dr Komaravolu

    Indian Academy of Sciences (India)

    Elected: 1959 Section: Mathematical Sciences. Chandrasekharan, Dr Komaravolu Ph.D. (Madras), FNA. Date of birth: 21 November 1920. Date of death: 13 April 2017. Specialization: Analysis and Theory of Numbers Last known address: Professor Emertius, Eidg. Technische Hochschule, Mathematik, ETH Zentrum, 8092 ...

  16. Mandal, Dr Asit Baran

    Indian Academy of Sciences (India)

    Mandal, Dr Asit Baran Ph.D. (Jadavpur), FRSC. Date of birth: 13 January 1952. Specialization: Electrochemistry, Thermodynamics, Ionic Liquids, Biophysical Chemistry, Organised Self-Assemblies and Nanomaterials Address: Central Glass & Ceramic Research Institute, 196, Raja SC Mullick Road, Jadavpur, Kolkata 700 ...

  17. Bhakuni, Dr Vinod

    Indian Academy of Sciences (India)

    Bhakuni, Dr Vinod Ph.D. (Lucknow), FNASc, FNA. Date of birth: 24 May 1962. Date of death: 15 July 2011. Specialization: Protein Folding and Molecular Biophysics Last known address: Division of Molecular & Structural Biology, Central Drug Research Institute, P.B. No. 173, Lucknow 226 001. YouTube; Twitter; Facebook ...

  18. Das, Dr Amitava

    Indian Academy of Sciences (India)

    Elected: 2010 Section: Chemistry. Das, Dr Amitava Ph.D. (Jadavpur), FNASc, FNA. Date of birth: 24 December 1959. Specialization: Molecular Reactions, Supramolecular Chemistry, Assembly Photo-included Processes Address: Director, Central Salt & Marine Chemicals Research Institute, GB Marg, Bhavnagar 364 002, ...

  19. Gangal, Dr Sharad Vishwanath

    Indian Academy of Sciences (India)

    Gangal, Dr Sharad Vishwanath Ph.D. (Mumbai), FNASc. Date of birth: 2 May 1937. Specialization: Allergy, Immunology and Biochemistry Address: Lakshmi Niwas, Opp. Santoshi Mata Temple (B Cabin), Sane Guruji Path, Naupada, Thane 400 602, Maharashtra Contact: Residence: (022) 2537 6961. Mobile: 93249 24307

  20. Brahm Prakash, Dr

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1972 Section: Engineering & Technology. Brahm Prakash, Dr Ph.D. (Panjab), FNA 1974-76. Date of birth: 21 August 1912. Date of death: 3 January 1984. Specialization: Metallurgy. YouTube · Twitter · Facebook · Blog ...

  1. Chakraborti, Dr Pradip K

    Indian Academy of Sciences (India)

    Elected: 2010 Section: General Biology. Chakraborti, Dr Pradip K Ph.D. (Visva Bharati), FNASc, FNA. Date of birth: 7 November 1956. Specialization: Biochemistry and Molecular Microbiology, Prokaryotic Signal Transduction. Address: Chief Scientist, Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, U.T.

  2. Rao, Dr Pendyala Balarama

    Indian Academy of Sciences (India)

    Elected: 1996 Section: Earth & Planetary Sciences. Rao, Dr Pendyala Balarama Ph.D. (Andhra). Date of birth: 15 February 1938. Specialization: Space Physics, Radiowave Propagation and Radar Systems Address: Member, ADCOS-DOS, National Remote Sensing Centre, Bldg No. 10, Balanagar, Hyderabad 500 037, A.P.

  3. Mishra, Dr Rakesh K

    Indian Academy of Sciences (India)

    Mishra, Dr Rakesh K Ph.D. (Allahabad), FNASc, FNA. Date of birth: 14 April 1961. Specialization: Genomics, Chromatin, Epigenetics Address: Director, Centre for Cellular & Molecular Biology, Uppal Road, Hyderabad 500 007, A.P.. Contact: Office: (040) 2719 2600. Residence: (040) 2720 6400. Mobile: 94419 02188

  4. Varadarajan, Dr Srinivasan

    Indian Academy of Sciences (India)

    Elected: 1972 Section: Chemistry. Varadarajan, Dr Srinivasan Ph.D. (Delhi and Cantab), D.Sc. (h.c.), D.Litt. (h.c.), FNA, FNAE, FTWAS Council Service:1974-88; Vice-President: 1977-79; President: 1980-82. Date of birth: 31 March 1928. Specialization: Organic & Biological Chemistry, Molecular Biology, Engineering Design ...

  5. Gharda, Dr Keki Hormusji

    Indian Academy of Sciences (India)

    Elected: 1976 Section: Chemistry. Gharda, Dr Keki Hormusji Ph.D. (Michigan). Date of birth: 25 September 1929. Specialization: Process Design of Organic Chemical Plants Address: Chairman and Managing Director, Gharda Chemical Limited, Jer Mansion, W.P. Warde Road, Off Turner Road, Bandra, Mumbai 400 050, ...

  6. Jana, Dr Subhra

    Indian Academy of Sciences (India)

    Associate Profile. Period: 2015–2018. Jana, Dr Subhra Ph.D. (IIT, Kharagpur). Date of birth: 22 March 1981. Specialization: Catalysis, Spectroscopy, Experimental Materials Science Address: Dept. of CBM Sciences, SN Bose Natl. Centre for, Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 106, W.B.. Contact:

  7. Ghosh, Dr Amit

    Indian Academy of Sciences (India)

    Elected: 2000 Section: Medicine. Ghosh, Dr Amit Ph.D. (Calcutta), D.Sc. (h.c.), FNASc, FNA. Date of birth: 24 November 1944. Specialization: Molecular Biology of V.cholerae and Recombinant DNA Technology Address: National Institute of Cholera and Enteric Diseases, JICA Building, CIT Scheme XM, Beliaghata, Kolkata ...

  8. Santhanam, Dr Vaidyanathaswamy

    Indian Academy of Sciences (India)

    Elected: 1974 Section: Plant Sciences. Santhanam, Dr Vaidyanathaswamy Ph.D. (Madras). Date of birth: 31 July 1925. Specialization: Plant Breeding & Genetics, Research Management and Cotton Development Address: 'Shri Abhirami', 107, Venkataswamy Road West, R S Puram Post, Coimbatore 641 002, T.N.. Contact:

  9. Rai, Dr Shyam Sundar

    Indian Academy of Sciences (India)

    Date of birth: 16 March 1954. Specialization: Geophysics, Data Analysis & Modelling Deep Earth Exploration Address: Chair, Earth & Climate Science, Indian Institute of Science Education & Research, Dr Homi Bhabha Road, Pashan, Pune 411 008, Maharasdhtra Contact: Office: (020) 2590 8255. Mobile: 98903 22705

  10. Purnachandra Rao, Dr Venigalla

    Indian Academy of Sciences (India)

    Purnachandra Rao, Dr Venigalla Ph.D. (Andhra), FNA. Date of birth: 10 October 1955. Specialization: Marine Geology, Authigenic Minerals and Palaeoclimate, Palaeo-sea-levels. Address: Emeritus Scientist, Department of Civil Engineering, Vignan's University, Vadlamudi 522 213, A.P.. Contact: Office: (0863) 234 4761

  11. Ganguly, Dr Chaitanyamoy

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1994 Section: Engineering & Technology. Ganguly, Dr Chaitanyamoy Ph.D. (Calcutta), FNA, FNAE, FNASc. Date of birth: 31 December 1946. Specialization: Fuel Cycle, Advanced Ceramics, Powder Metallurgy and Uranium, Thorium & Plutonium Fuels Address: Caladia 703, The Botanika, Kondapur, ...

  12. Asundi, Dr Moodalagiri Kushalrao

    Indian Academy of Sciences (India)

    Asundi, Dr Moodalagiri Kushalrao Ph.D. (London). Date of birth: 1 May 1930. Date of death: 1 December 2003. Specialization: Physical Metallurgy and Structural & Mechanical Properties of Materials Last known address: Consulting Metallurgist, No. 44, 'VIBHA', Ramakrishna Paramahamsa Marg, Bandra East, Mumbai 400 ...

  13. Adyalkar, Dr Pandurang Ganpatrao

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1974 Section: Earth & Planetary Sciences. Adyalkar, Dr Pandurang Ganpatrao Ph.D. (Nagpur), FNASc. Date of birth: 3 December 1927. Date of death: 13 November 2007. Specialization: Geology, Hydrogeology, Seismology and Mining & Environment Last known address: Millennium Shopping Mall, ...

  14. Nageswara Rao, Dr Gullapalli

    Indian Academy of Sciences (India)

    Nageswara Rao, Dr Gullapalli M.D. (Opthal.) (AIIMS), FAMS, FACS, FRCS, FNASc. Date of birth: 1 September 1945. Specialization: Cornea, Community Eye Health and Eye Care Policy & Planning Address: Distinguished Chair of Eye Health, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, A.P.

  15. Bhakuni, Dr Dewan Singh

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1983 Section: Chemistry. Bhakuni, Dr Dewan Singh Ph.D. and D.Sc. (London), FNA, FNASc. Date of birth: 30 December 1930. Specialization: Natural Products, Bio-organic, Biosynthesis, Nucleosides and Medicinal Chemistry Address: C-132, Nirala Nagar, Lucknow 226 020, U.P.

  16. Anand, Dr Nitya

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1974 Section: Chemistry. Anand, Dr Nitya Ph.D. (Mumbai and Cantab), FNA, FNASc. Council Service: 1980-82. Date of birth: 1 January 1925. Specialization: Medicinal Chemistry Address: Lumbini, B-62, Nirala Nagar, Lucknow 226 020, U.P.. Contact: Residence: (0522) 278 8587, (0522) 404 3229

  17. Kumar, Dr Praveen

    Indian Academy of Sciences (India)

    Period: 2016–2019. Kumar, Dr Praveen Ph.D. (Uni. South Calif.) Date of birth: 14 September 1982. Specialization: Mechanical Behaviour of Materials, Electromigration, Microelectronic packages. Address: Dept. of Materials Engg., Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2293 3369

  18. Bapat, Dr Sharmila Avadhut

    Indian Academy of Sciences (India)

    Elected: 2015 Section: Medicine. Bapat, Dr Sharmila Avadhut Ph.D. (Pune), FNASc. Date of birth: 20 November 1965. Specialization: Cancer Biology & Stem Cells Address: National Centre for Cell Science, NCCS Complex, University Campus, Ganeshkhind, Pune 411 007, Maharashtra Contact: Office: (020) 2570 8089

  19. Chitnis, Dr Chetan Eknath

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: Medicine. Chitnis, Dr Chetan Eknath Ph.D. (UC, Berkeley), FNA. Date of birth: 3 April 1961. Specialization: Molecular Parasitology, Vaccine Development for Malaria and Molecular & Cell Biology Address: Head, Malaria Parasite Biology & Vaccine, Institut Pasteur, 28, ...

  20. Gahalaut, Dr Vineet Kumar

    Indian Academy of Sciences (India)

    Elected: 2018 Section: Earth & Planetary Sciences. Gahalaut, Dr Vineet Kumar Ph.D. (Roorkee). Date of birth: 26 September 1966. Specialization: Seismology, Tectonic Geodesy, Geodynamics Address: National Centre for Seismology, Ministry of Earth Sciences, IMD Complex, Lodi Road, New Delhi 110 003, U.T.. Contact:

  1. Agrewala, Dr Javed Naim

    Indian Academy of Sciences (India)

    Agrewala, Dr Javed Naim Ph.D. (Agra), FNA, FNASc. Date of birth: 14 May 1961. Specialization: Immunology, Vaccine, Drug Discovery Address: Chief Scientist, Immunology Laboratory, Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, U.T.. Contact: Office: (0172) 666 5261. Residence: (0172) 666 5514

  2. Chandy, Dr Jacob

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1961 Section: Medicine. Chandy, Dr Jacob MBBS (Madras), FRCS (c) Council Service: 1962-70. Date of birth: 23 January 1910. Date of death: 23 June 2007. Specialization: Neurology, Neurosurgery and Medical Education Address: Paarra, Matteethra, Kottayam 686 004.

  3. Thakur, Dr Vikram Chandra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1991 Section: Earth & Planetary Sciences. Thakur, Dr Vikram Chandra Ph.D. (London). Date of birth: 15 January 1940. Specialization: Structural Geology, Tectonics of Himalayan Geology and Active Tectonics Address: 9/12 (Lane 9), Ashirwad Eclave, Dehra Dun 248 001, Uttarakhand Contact:

  4. Dastidar, Dr Pranab Rebatiranjan

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Engineering & Technology. Dastidar, Dr Pranab Rebatiranjan B.E., Ph.D. (Manchester). Date of birth: 10 July 1933. Specialization: Electronics, Controls and Nuclear Power Address: F-3, Rajkunj Co-op. Housing Society, Wadhavli, Chembur, Mumbai 400 074., Maharashtra Contact:

  5. Chandrashekar, Dr Tavarekere Kalliah

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2000 Section: Chemistry. Chandrashekar, Dr Tavarekere Kalliah Ph.D. (IISc), FNASc, FNA, FTWAS Council Service: 2013-15. Date of birth: 1 January 1956. Specialization: Bio-inorganic Chemistry, Synthetic Inorganic Chemistry and Catalysis Address: Senior Professor, School of Chemical Sciences, ...

  6. Grover, Dr Arun Kumar

    Indian Academy of Sciences (India)

    Elected: 1997 Section: Physics. Grover, Dr Arun Kumar Ph.D.(Mumbai), FNASc. Council Service: 2016-. Date of birth: 12 December 1951. Specialization: Magnetism & Superconductivity, Vortex State Studies in Superconductors, Strongly Correlated Systems Address: Vice Chancellor, Panjab University, Chandigarh 160 014 ...

  7. Budhani, Dr Ramesh Chandra

    Indian Academy of Sciences (India)

    Budhani, Dr Ramesh Chandra Ph.D. (IIT, Delhi), FNASc, FNA. Date of birth: 3 February 1955. Specialization: Renewable Energy, Nanoscale Systems, Experimental Condensed Matter Physics, Superconductivity and Magnetism Address: Department of Physics, Lasers & Photonics, Indian Institute of Technology, Kanpur 208 ...

  8. Anil Kumar, Dr

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Section: Chemistry. Anil Kumar, Dr Ph.D. (Pune), FNASc, FNA. Date of birth: 31 December 1955. Specialization: Chemical Thermodynamics, Physical Organic Chemistry and ... Office: (020) 2590 2278. Residence: (020) 2588 8712. Mobile: 98220 74509. Fax: (020) 2590 2636

  9. Vrati, Dr Sudhanshu

    Indian Academy of Sciences (India)

    Vrati, Dr Sudhanshu Ph.D. (ANU, Canberra), FNASc. Date of birth: 19 March 1960. Specialization: Molecular Virology, Vaccinology and Biotechnology Address: Executive Director, Regional Centre for Biotechnology, NCR Biotech Science Cluster, III Mailstone, Fairadabad-Gurgaon Expressway, Faridabad 121 001, Haryana

  10. Majumdar, Dr Subeer Suhash

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2014 Section: Animal Sciences. Majumdar, Dr Subeer Suhash Ph.D. (nagpur), FNA, FNASc. Date of birth: 21 May 1961. Specialization: Animal Biotechnology, Transgenic Animals, Endocrinology Address: Director, National Institute of Animal Biotechnology, Gopan Pally, Hyderabad 500 046, A.P.

  11. Anguli, Dr Vazhapat Chinnaswami

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1962 Section: Medicine. Anguli, Dr Vazhapat Chinnaswami M.D. (Madras), FRCP. Date of birth: 25 October 1919. Date of death: 22 July 2000. Specialization: Neuropathology, Experimental Pathology and Oncopathology Last known address: T36/2, 14, First Avenue, Besant Nagar, Chennai 600 090.

  12. Watve, Dr Milind Gajanan

    Indian Academy of Sciences (India)

    Ph.D. (IISc), FNA. Date of birth: 12 December 1957. Specialization: Wildlife Ecology & Animal Cognition, Evolutionary Biology, Computational Biology and Microbial Diversity Address: Professor, Biology, Indian Institute of Science Education & Research, Dr Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra Contact:

  13. Ramadas, Dr Trivandrum Ramakrishnan

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1998 Section: Mathematical Sciences. Ramadas, Dr Trivandrum Ramakrishnan Ph.D. (Mumbai). Date of birth: 30 March 1955. Specialization: Geometry and Mathematical Physics Address: Professor, Chennai Mathematical Institute, H-1, SIPCOT IT Park, Siruseri, Kelambakkam, Chennai 603 103

  14. Abrol, Dr Yash Pal

    Indian Academy of Sciences (India)

    Abrol, Dr Yash Pal Ph.D. (Chicago), FNA, FNASc, FNAAS. Date of birth: 23 December 1935. Specialization: Agriculture: Crop Physiology, Environmental Sciences Address: Chief Patron, Society for Conservation of Nature, Room No. F4, A Block, NASC Complex, Dev Prakash Shastry Marg, P.O. Pusa, New Delhi 110 012, ...

  15. Dey, Dr Gautam Kumar

    Indian Academy of Sciences (India)

    Elected: 2008 Section: Engineering & Technology. Dey, Dr Gautam Kumar Ph.D. (BHU), FNAE. Date of birth: 8 June 1957. Specialization: Phase Transformations in Metals & Alloys, Electron Microscopy and Metallic Glasses & Nanocrystalline Materials Address: Head, Materials Science Division, Bhabha Atomic Research ...

  16. Salunke, Dr Dinakar Mashnu

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2001 Section: General Biology. Salunke, Dr Dinakar Mashnu Ph.D. (IISc), FNASc, FNA, FTWAS. Date of birth: 1 July 1955. Specialization: Structural Biology, Macromolecular Crystallography and Immunology Address: Director, International Centre for Genetic Engineering, & Biotechnology, Aruna Asaf ...

  17. In the postmodern mirror: intertextuality in Angels and Insects by Antonia Susan Byatt

    Directory of Open Access Journals (Sweden)

    Buda Agata

    2015-05-01

    Full Text Available The aim of the paper is to analyse the novel Angels and Insects by Antonia Susan Byatt in terms of intertextual references. The author’s assumptions are based on the categorisation by Ryszard Nycz, who distinguishes three major types of intertexts: text versus text, text versus literary genre and text versus mimesis. Byatt uses intertextuality mainly to comment on the role of nature in the world, as well as to enhance the importance of human relationship with nature. Moreover, the writer moves towards literary criticism, discussing poems by famous artists, such as Alfred Tennyson or John Milton. In this way, the novel by Byatt is also an example of metafiction. All the narration techniques used by the English writer make the novel a typically postmodern work of art.

  18. Intermittent large amplitude internal waves observed in Port Susan, Puget Sound

    Science.gov (United States)

    Harris, J. C.; Decker, L.

    2017-07-01

    A previously unreported internal tidal bore, which evolves into solitary internal wave packets, was observed in Port Susan, Puget Sound, and the timing, speed, and amplitude of the waves were measured by CTD and visual observation. Acoustic Doppler current profiler (ADCP) measurements were attempted, but unsuccessful. The waves appear to be generated with the ebb flow along the tidal flats of the Stillaguamish River, and the speed and width of the resulting waves can be predicted from second-order KdV theory. Their eventual dissipation may contribute significantly to surface mixing locally, particularly in comparison with the local dissipation due to the tides. Visually the waves appear in fair weather as a strong foam front, which is less visible the farther they propagate.

  19. (REREADING INDEX CARDS: THE ARCHIVIST AS INTERPRETER IN SUSAN PUI SAN LOK'S 'NEWS'

    Directory of Open Access Journals (Sweden)

    Sandra Camacho

    2018-01-01

    Full Text Available Looking at susan pui san lok's projects News (2005 and RoCH (2013, this paper contemplates the notions put forward by Michel-Rolph Trouillot and Jacques Derrida on the power of archivists, not solely as guardians of documents but also as their interpreters. Taking into consideration that photographic and moving image archives present unique difficulties in their cataloguing processes, I examine silences that might be generated by a thematic classification that is not impervious to archivists' biases. Moreover, I consider if the silences created by manual processes of classification and retrieval might be surpassed through digital technologies, or if it is possible that new technologies simply create different types of silencing.

  20. "I Am Not a Fairy Tale": Contextualizing Sioux Spirituality and Story Traditions in Susan Power's "The Grass Dancer"

    Science.gov (United States)

    Diana, Vanessa Holford

    2009-01-01

    Standing Rock Sioux writer Susan Power's best-selling novel "The Grass Dancer" (1994) includes depictions of the supernatural and spiritual that do not conform to the Judeo-Christian or, in some cases, the atheist or rationalist worldviews of many readers. Power writes of ghost characters and haunted places, communication between the living and…

  1. 78 FR 75676 - Mark W. Dobronski and Susan K. Dobronski-Acquisition of Control Exemption-Adrian & Blissfield...

    Science.gov (United States)

    2013-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Mark W. Dobronski and Susan K. Dobronski--Acquisition of Control Exemption... Company, Lapeer Industrial Railroad Company and Jackson & Lansing Railroad Company Mark W. Dobronski and...

  2. DR og musikken

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    1991-01-01

    Musikken i radioen er et af de mange underbelyste temaer inden for me- dieforskningen i Danmark. Forfatteren til den følgende artikel har gennem nogle år arbejdet som musik-medarbejder i Danmarks Radio - med base i Østjyllands Radio. I artiklen fokuserer han på produktionsaspektet. Hvilke funktio...... rejses spørgsmålet om musikkens rolle i DR som aktiverende eller registrerende i forhold til det musikliv, som findes uden for institutionen....

  3. Dr. Faustus: Theist or Atheist?

    Science.gov (United States)

    Karim, Shah Mohammad Sanaul; Fathema, Fawzia; Hakim, Abdul

    2015-01-01

    Dr. Faustus is the greatest but the most controversial of Marlowe's plays. Among the causes of controversy, whether Dr. Faustus is an atheist or theist deserves utmost attention. This paper is intended to deal with the issue. Though at various stages of the development of the action, Dr. Faustus abjures Trinity, resorts to necromancy, becomes…

  4. Dr Math at your service

    CSIR Research Space (South Africa)

    Butgereit, L

    2012-10-01

    Full Text Available in the fraction you have Pupil: 1 ova 15 Dr Math: so do the actual division what is one divided by 15 Pupil: is 15 Dr Math: no use a calcluator Pupil: 0,06 Dr Math: well it is 0,0666666 recurring right? Pupil: yes it is Dr Math...: now for a percentage, move the decimal 2 points to the right so it is 6.666% recurring then round to 6.67% MXit: drmath.sa Google Chat: dr.math.rsa (at) gmail.com More Info: http://drmath.meraka.csir.co.za/drmath Photographs...

  5. Gaia DR1 documentation

    Science.gov (United States)

    van Leeuwen, F.; de Bruijne, J. H. J.; Arenou, F.; Comoretto, G.; Eyer, L.; Farras Casas, M.; Hambly, N.; Hobbs, D.; Salgado, J.; Utrilla Molina, E.; Vogt, S.; van Leeuwen, M.; Abreu, A.; Altmann, M.; Andrei, A.; Babusiaux, C.; Bastian, U.; Biermann, M.; Blanco-Cuaresma, S.; Bombrun, A.; Borrachero, R.; Brown, A. G. A.; Busonero, D.; Busso, G.; Butkevich, A.; Cantat-Gaudin, T.; Carrasco, J. M.; Castañeda, J.; Charnas, J.; Cheek, N.; Clementini, G.; Crowley, C.; Cuypers, J.; Davidson, M.; De Angeli, F.; De Ridder, J.; Evans, D.; Fabricius, C.; Findeisen, K.; Fleitas, J. M.; Gracia, G.; Guerra, R.; Guy, L.; Helmi, A.; Hernandez, J.; Holl, B.; Hutton, A.; Klioner, S.; Lammers, U.; Lecoeur-Taïbi, I.; Lindegren, L.; Luri, X.; Marinoni, S.; Marrese, P.; Messineo, R.; Michalik, D.; Mignard, F.; Montegriffo, P.; Mora, A.; Mowlavi, N.; Nienartowicz, K.; Pancino, E.; Panem, C.; Portell, J.; Rimoldini, L.; Riva, A.; Robin, A.; Siddiqui, H.; Smart, R.; Sordo, R.; Soria, S.; Turon, C.; Vallenari, A.; Voss, H.

    2017-12-01

    We present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7 in the white-light photometric band G of Gaia. The Gaia Data Processing and Analysis Consortium (DPAC) processed the raw measurements collected with the Gaia instruments during the first 14 months of the mission, and turned these into an astrometric and photometric catalogue. Gaia DR1 consists of three parts: an astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues (the primary astrometric data set) and the positions for an additional 1.1 billion sources (the secondary astrometric data set). The primary set forms the realisation of the Tycho-Gaia Astrometric Solution (TGAS). The second part of Gaia DR1 is the photometric data set, which contains the mean G-band magnitudes for all sources. The third part consists of the G-band light curves and the characteristics of 3000 Cepheid and RR Lyrae stars observed at high cadence around the south ecliptic pole. The positions and proper motions in the astrometric data set are given in a reference frame that is aligned with the International Celestial Reference Frame (ICRF) to better than 0.1 mas at epoch J2015.0, and non-rotating with respect to the ICRF to within 0.03 mas yr^-1. For the primary astrometric data set, the typical standard error for the positions and parallaxes is about 0.3 mas, while for the proper motions the typical standard error is about 1 mas yr^-1. Whereas it has been suggested in Gaia Collaboration et al. (2016a) that a systematic component of ∼0.3 mas should be 'added' (in quadrature) to the parallax uncertainties, Brown (2017) clarifies that reported parallax standard errors already include local systematics as a result of the calibration of the TGAS parallax uncertainties by comparison to Hipparcos parallaxes. For the subset of

  6. A Journey, the Pain of Others, and Historical Experience: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma

    2014-12-01

    Full Text Available The author interprets Susan Silas' Helmbrechts walk (1998-2003, a unique series of forty-five photographs and supplementing visual and textual materials collected during the walk along the route of two hundred and twenty-five miles. The walk repeats the route which in 1945 had to undertake women prisoners from the concentration camp in Helmbrechts near Flossenbürg in their death march to Prachatice in Czech Republic. The pictures Silas takes, the people she meets, and finally the trees, the very materiality of the road become the factors of creating her own, individual memory of the event from the past. Silas selects an object from "the margins of the Holocaust" – a forgotten event that she re-presents by reacting to contemporary objects placed along the route of the event. Silas' work offers an opportunity to critically review the concept of memory landscapes (where is memory located in a landscape? and the phenomenon of dark tourism (is following in the footsteps of the prisoners a kind of pilgrimage, tourism, or therapy?. Silas problematises the question of memory, as well as examines different kinds of non-memory. Her camera is directed at locations that can be termed "the non-sites of memory."

  7. UNDERSTANDİNG SUSAN BORDO AND HER WORK; UNBEARABLE WEİGHT :FEMİNİSM, WESTERN CULTURE, BODY

    Directory of Open Access Journals (Sweden)

    ÇAĞLAR DEMİR

    2017-02-01

    Full Text Available Throughout history of thought, there have been many views about the women, their status in society, their struggle with patriarchy, and inequality  applied to them in all areas. There are different ways of oppression on women, such as confinement to home, inequality in wages between both sexes.  However, few scholars have written and declared their own views about how the patriarchal world and companies form women as they wish. Susan Bordo is one of  the most outstanding and distinguished feminist writers in the world who focuses on  how patriarchal capitalist understanding works on women’s body in terms of weight and weakness. According to Susan Bordo, male dominated capital world decides on women about what to wear and what to eat and women try to lose weight to be in the form men wish. State of  starving all the time leads to an illness called anorexia. The writer bases her views on the thoughts of literary critic and thinker, Foucault. The  objective of this article is to help the readers understand Susan Bordo’s views and analyse her impressive work; Unbearable Weight: Feminism, Western Culture and  the Body  and make her known in academic world.

  8. Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer

    Directory of Open Access Journals (Sweden)

    Alejandro García-Reidy

    2016-01-01

    Full Text Available Reseña de Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer, Bucknell University Press, Lewisburg, 2013, 298 pp. ISBN 9781611485172.

  9. Doctors and Dr. Seuss.

    Science.gov (United States)

    Carlin, Nathan

    2015-01-01

    In 2012, Dartmouth College renamed its medical school, founded in 1797, the Audrey and Theodor Geisel School of Medicine. Using the renaming of the medical school of Dartmouth College as a foil, I offer in this article a vision of what it might mean to align Theodor Geisel, better known as Dr. Seuss, with doctors by examining Geisel's You're Only Old Once! A Book for Obsolete Children. In this article, I derive four critiques of modern medicine from the book and offer four strategies as to how these critiques could be explored in medical education. If You're Only Old Once! is read as a pathography, I argue that it can be used as a resource for medical education.

  10. David Brailer on a private-public health information technology infrastructure. Interview by Susan V. White.

    Science.gov (United States)

    Brailer, David

    2004-01-01

    David Brailer, MD PhD, was appointed the first National Health Information Technology Coordinator by the U.S. Department of Health and Human Services Secretary Tommy Thompson on May 6, 2004. As National Coordinator he is to execute President Bush's Executive Order of April 27, 2004, calling for widespread deployment of health information technology (HIT) within 10 years. Dr. Brailer is an authority on clinical data sharing, local health information exchanges, and the use of peer-to-peer technologies in healthcare. He is a leader in the strategy and financing of quality and efficiency in healthcare, with a particular emphasis on HIT and health systems management. Previously, Dr. Brailer was a Senior Fellow at the Health Technology Center in San Francisco, advising a variety of regional and national data-sharing projects and several major corporations about the role of IT in improving the quality of healthcare. Dr. Brailer recently completed 10 years as Chairman and CEO of CareScience, Inc., a provider of care management services and Internet-based solutions that help reduce medical errors and improve physician and hospital-based performance. Dr. Brailer holds doctoral degrees in both medicine and economics. While in medical school, he was a Charles A. Dana Scholar at the University of Pennsylvania School of Medicine and the first recipient of the National Library of Medicine Martin Epstein Award for his work in expert systems. Dr. Brailer was among the first medical students to serve on the Board of Trustees of the American Medical Association.

  11. Podróż, cudze cierpienie i doświadczenie historyczne: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma

    2014-12-01

    Full Text Available Autorka interpretuje pracę Susan Silas Helmbrechts walk (1998-2003, szczególny cykl czterdziestu pięciu zdjęć i dołączonych do nich materiałów wizualnych oraz tekstowych zbudowany podczas przejścia trasy dwustu dwudziestu pięciu mil, które w 1945 roku musiały przebyć kobiety pędzone w marszu śmierci z Helmbrecht koło Flossenbürga do czeskich Prachatic. Wykonywane zdjęcia, napotykani ludzie, w końcu – drzewa, sama materialność drogi stają się czynnikami wytwarzania własnej, indywidualnej pamięci wydarzenia sprzed lat. Silas wybiera szczególny obiekt "z marginesów Zagłady" – zapomniane zdarzenie, które przedstawia obserwując współczesne obiekty położone wzdłuż trasy tego zdarzenia. Praca Silas pozwala przyjrzeć się krytycznie koncepcji memory landscapes (gdzie w krajobrazie umiejscawia się pamięć? i zjawisku dark tourism (czy podążanie śladami więźniarek to pielgrzymka, turystyka czy terapia?. Silas problematyzuje nie tylko kwestię pamięci, bada również rodzaje nie-pamiętania. Jej kamera zostaje zwrócona ku lokalizacjom, które można nazwać "nie-miejscami pamięci".

  12. Treasure Your Exceptions: An Interview with 2017 George Beadle Award Recipient Susan A. Gerbi.

    Science.gov (United States)

    Gerbi, Susan A

    2017-12-01

    THE Genetics Society of America's (GSA) George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake. The 2017 recipient is Susan A. Gerbi, who has been a prominent leader and advocate for the scientific community. In the course of her research on DNA replication, Gerbi helped develop the method of Replication Initiation Point (RIP) mapping to map replication origins at the nucleotide level, improving resolution by two orders of magnitude. RIP mapping also provides the basis for the now popular use of λ-exonuclease to enrich nascent DNA to map replication origins genome-wide. Gerbi's second area of research on ribosomal RNA revealed a conserved core secondary structure, as well as conserved nucleotide elements (CNEs). Some CNEs are universally conserved, while other CNEs are conserved in all eukaryotes but not in archaea or bacteria, suggesting a eukaryotic function. Intriguingly, the majority of the eukaryotic-specific CNEs line the tunnel of the large ribosomal subunit through which the nascent polypeptide exits. Gerbi has promoted the fly Sciara coprophila as a model organism ever since she used its enormous polytene chromosomes to help develop the method of in situ hybridization during her Ph.D. research in Joe Gall's laboratory. The Gerbi laboratory maintains the Sciara International Stock Center and manages its future, actively spreading Sciara stocks to other laboratories. Gerbi has also served in many leadership roles, working on issues of science policy, women in science, scientific training, and career preparation. This is an abridged version of the interview. The full interview is available on the Genes to Genomes blog, at genestogenomes.org/gerbi. Copyright © 2017 by the Genetics Society of America.

  13. From Mxit to Dr Math

    CSIR Research Space (South Africa)

    Botha, Adèle

    2013-02-01

    Full Text Available In 2007, Laurie Butgereit, a researcher at the CSIR Meraka Institute, started to use Mxit as a communication channel to tutor her son in mathematics. Her son and a number of his friends logged in, and Dr Math was born. At the inception of Dr Math...

  14. Teaching Peace with Dr. Seuss.

    Science.gov (United States)

    Pace, Rosemarie; Podesta, Andrea

    1999-01-01

    Educators seeking novel ways to instill conflict-resolution skills in young children should consider Dr. Seuss, whose books provide a synthesis of fantasy and reality that works for teaching values endemic to peace education. This paper discusses how students can learn peace and educators can teach peace using Dr. Seuss books, examining steps to…

  15. Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland

    CERN Document Server

    Patrice Loïez

    2002-01-01

    Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland visiting the ATLAS magnet assembly hall, building 180 with Mr Carlo Lamprecht, State Councillor, Dr Stanislaw Huskowski and Dr Peter Jenni, ATLAS Spokesperson

  16. Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland visiting the ATLAS magnet assembly hall, building 180. From l to r: Mr Carlo Lamprecht, State Councillor, Dr Stanislaw Huskowski and Dr Peter Jenni, ATLAS Spokesperson

  17. How Dr. Pierce Promoted Himself

    Data.gov (United States)

    Department of the Interior — This article is about Dr. Raymond V Pierce who owned St. Vincent Island before it became a refuge. The doctor painted advertisements for his famous “Woman’s Tonic”...

  18. Diabetic retinopathy (DR: everybody's business

    Directory of Open Access Journals (Sweden)

    David Yorston

    2011-09-01

    Full Text Available Diabetes is on the increase worldwide, due mainly to the rise in the number of people with type 2 diabetes. Type 2 diabetes is becoming more common because:* People are living longer, and diabetes is more prevalent in older people.* As people increasingly migrate to urban areas, exercise less, eat more, and eat less healthy food, more people are becoming obese – a primary cause of type 2 diabetes.Diabetes increases the risk of a range of eye diseases, including cataract, but the main cause of blindness associated with diabetes is diabetic retinopathy (DR. DR usually develops between ten and twenty years after the onset of diabetes, and develops faster when diabetes is undiagnosed and untreated.People with DR whose sight is at risk can be treated, most commonly with laser, to prevent visual impairment and blindness. Sadly, there is no treatment that can restore vision that has already been lost.

  19. Tribute to Dr Jacques Rogge

    DEFF Research Database (Denmark)

    Bourgois, Jan G; Dumortier, Jasmien; Callewaert, Margot

    2017-01-01

    'A tribute to Dr J. Rogge' aims to systematically review muscle activity and muscle fatigue during sustained submaximal quasi-isometric knee extension exercise (hiking) related to Olympic dinghy sailing as a tribute to Dr Rogge's merits in the world of sports. Dr Jacques Rogge is not only the for...... muscle. Since maximal strength is an important determinant of neuromuscular fatigue during hiking, combined strength and endurance training should be incorporated in the training program of dinghy sailors.......% predicted by a higher maximal isometric quadriceps strength. Although useful in exercise testing, prediction of hiking endurance capacity based on the changes in surface EMG in thigh and trunk muscles during a hiking maintenance task is not reliable. This could probably be explained by the varying exercise...

  20. Susan Magoffin’s Santa Fe Days in 1846: The Value of Testimony Les journées de Santa Fé en 1846 de Susan Magoffin : la valeur du témoignage

    Directory of Open Access Journals (Sweden)

    Susanne Berthier-Foglar

    2009-11-01

    Full Text Available Susan Magoffin, la jeune épouse d’un commerçant de la piste de Santa Fe, accompagna son mari en 1846 pour un voyage où la caravane suivait de près l’Armée de l’Ouest et pendant lequel elle tint un journal. Cet article traite des 37 jours que dura la pause de la caravane à Santa Fe et aborde plus spécifiquement la façon dont l’auteur appréhendait l’altérité dans un environnement inhabituel et parfois dangereux. Pour apprécier la valeur du témoignage, je combine une analyse du discours avec une évaluation statistique du contenu. La description, parfois naïve, de Santa Fe sous l’occupation américaine illustre les raisons de la guerre contre le Mexique. En tant qu’agent de la destinée manifeste, Susan Magoffin admirait le général Kearny en lui attribuant des qualités surhumaines et en participant à ses efforts de propagande. Alors qu’elle était enracinée dans sa classe et sa culture, elle voyait la population mexicaine et les Amérindiens avec un esprit ouvert bien que ses motifs pour apprendre l’espagnol, ainsi que le métier de commerçante, avaient une fonction plus prosaïque.

  1. Dr. von Braun With Management Team

    Science.gov (United States)

    1961-01-01

    Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

  2. DR. MIKA MAJALE MEMORIAL LECTURE

    African Journals Online (AJOL)

    tuberculosis and polio. The first indigenous orthopaedic surgeon was. Dr. Mika Majale. ... but was posted to Kisii then Mombasa where he spent all his orthopaedic life. The other orthopaedic surgeons were in .... dissertations done by some of the post graduate students are excellent, but they are simply left in the hard cover.

  3. Anand Kumar, Dr Trichnopoly Chelvaraj

    Indian Academy of Sciences (India)

    Elected: 1981 Section: Animal Sciences. Anand Kumar, Dr Trichnopoly Chelvaraj Ph.D. (Rajasthan), D.Sc. (Mumbai). Date of birth: 18 June 1936. Date of death: 26 January 2010. Specialization: Human Reproduction Last known address: Chairman, Hope Infertility Clinic & Research Foundation, 33/1, Aga Abbas Ali Road, ...

  4. Anandavardhanan, Dr U.K.

    Indian Academy of Sciences (India)

    Home; Fellowship; Associateship. Associate Profile. Period: 2007–2010. Anandavardhanan, Dr U.K.. Date of birth: 25 May 1976. Address during Associateship: Department of Mathematics, Indian Institute of Technology, Powai, Mumbai - 400 076. Contact: Email: anand@math.iitb.ac.in. YouTube; Twitter; Facebook; Blog ...

  5. Dr. John Marburger visits DESY

    CERN Multimedia

    2003-01-01

    Dr. John Marburger, Director of the United States Office of Science and Technology Policy, visited the research center DESY in Hamburg. The American physicist wanted to inform himself about the status of the TESLA X-ray laser and the TESLA linear collider as well as the international collaboration at DESY (1/2 page).

  6. Shastry, Dr Sishta Venkata Seetharama

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Plant Sciences. Shastry, Dr Sishta Venkata Seetharama Ph.D. (Wisconsin), FNA. Date of birth: 4 November 1928. Specialization: Cytogenetics, Taxonomy, Plant Breeding and Rice Development Address: 'Ashoka', 204, Gautami Apartments, Barkatpura, Hyderabad 500 027, A.P.

  7. Beig, Dr Gufran-Ullah

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2009 Section: Earth & Planetary Sciences. Beig, Dr Gufran-Ullah Ph.D. Ahmedabad. Date of birth: 24 May 1961. Specialization: Atmospheric Sciences, Global Change & Atmospheric Environment, Urban Air Pollution & Chemical-Climate Change, 2-D & 3-D Atmospheric Chemical Transport Modelling

  8. Ali, Dr Moizuddin Abdul Salim

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Animal Sciences. Ali, Dr Moizuddin Abdul Salim D.Sc. (Andhra), D.Sc. (h.c.), FNA. Date of birth: 12 November 1896. Date of death: 20 June 1987. Specialization: Ecology, Zoogeography, Nature Conservation, Ornithology Last known address: No. 46, Pali Hill, Bombay 400 050.

  9. Murty, Dr Thutupalli Gopala Krishna

    Indian Academy of Sciences (India)

    Elected: 2002 Section: Engineering & Technology. Murty, Dr Thutupalli Gopala Krishna Ph.D. (Adelaide). Date of birth: 11 February 1944. Specialization: Optical Engineering, Thin Film Technology, Electro-Optical Instrumentation and Atmospheric Science Technologies Address: 848, 8th B Main, 17th Cross, ISRO Layout, ...

  10. In Memoriam Dr. M. Jacobs

    NARCIS (Netherlands)

    Kalkman, C.

    1983-01-01

    Dr. Marius Jacobs, a senior staff member of the Rijksherbarium, died suddenly on 28 April 1983, following a heart attack some days earlier. He was only 53 years old and his death came as a great shock, not only to his colleagues at our institute. Jacobs was a many-sided man with interests in many

  11. Rao, Dr Kanury Venkata Subba

    Indian Academy of Sciences (India)

    Rao, Dr Kanury Venkata Subba Ph.D. (Baroda), FNA, FNASc. Date of birth: 27 September 1958. Specialization: Synthetic Peptides, Cell Signalling, Biology of Tuberculosis Infection, Systems Biology Address: Head, DDRC, Translational Health Science & Technbology Institute, NCR Biotech, Science Cluster, Faridabad 121 ...

  12. Raghava, Dr Gajendra Pal Singh

    Indian Academy of Sciences (India)

    Raghava, Dr Gajendra Pal Singh Ph.D. (Chandigarh), FNASc. Date of birth: 25 May 1963. Specialization: Bioinformatics, Cancer Genomics, Immunoinformatics, Drug Design, Subunit Vaccine Design Address: Head, Centre for Computational Biology, Indraprastha Institute of Information Technology, Okhla, Phase 3, New ...

  13. Sproglige drømmerier

    DEFF Research Database (Denmark)

    Farø, Ken Joensen

    2015-01-01

    blev tidligere brugt i Danmarks Radio som pausesignal, afspillet på en spilledåse. Ak ja, det var dengang. Gå ind på nettet og lyt til den, hvis du ikke kender melodien. Det er national kulturarv. Mange bevingede ord indeholder en form af ”drøm(me)”, fx Martin Luther Kings ”I have a Dream”. Eller...

  14. Dr. Francis Collins Is New NIH Director

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Dr. Francis Collins Is New NIH Director Past Issues / ... for NIH and for science in this country." "Dr. Collins is one of our generation's great scientific ...

  15. FOREWORD: Dr Trevor J Hicks Dr Trevor J Hicks

    Science.gov (United States)

    Goossens, Darren

    2009-03-01

    This issue of Journal of Physics: Condensed Matter has been assembled to recognize the valuable contribution of Dr Trevor J Hicks to the field of neutron scattering and magnetism. Trevor began his study of magnetism as a PhD student at Monash University in Melbourne in the early 1960s, working with Professor Jack Smith. From the very beginning magnetism in alloys, and disordered systems in general, became a key aspect of his career. After a postdoctoral position at Harwell working with Dr Graeme Low Trevor returned to Australia and took up a position with Monash. He soon became a key figure in developing the capability for neutron scattering using the HIFAR reactor at the Australian Atomic Energy Commission, now the Australian Nuclear Science and Technology Organisation, ANSTO. The instrumentation was always developed to further his studies of magnetism. The development of polarization analysis measurements of diffuse magnetic scattering, first using iron filters and then his own design of supermirror benders for beam polarization, took place through the 1970s, 1980s and into the 1990s. Throughout this time, Trevor mentored a series of PhD students and postdoctoral fellows, many of whom have contributed to this issue (and, indeed, guest edited it). As befits a scientist and university academic for whom teaching has always been important, Trevor has not only created a strong body of significant research, he has also made a major contribution to preparing several generations of neutron scattering scientists, and this issue reflects that. When I approached Journal of Physics: Condensed Matter with a proposal for an issue in honour of Trevor, the response was immediate and positive. It is with great pleasure that I present the result of that proposal. The great diversity of the content, all centred on neutron scattering and magnetism, reflects the breadth of Trevor's own career and of the scientists with whom he has interacted. Finally, I would like to make some

  16. ‘Speaking Kleinian’: Susan Isaacs as Ursula Wise and the Inter-War Popularisation of Psychoanalysis

    Science.gov (United States)

    Shapira, Michal

    2017-01-01

    How did the complex concepts of psychoanalysis become popular in early twentieth-century Britain? This article examines the contribution of educator and psychoanalyst Susan Isaacs (1885–1948) to this process, as well as her role as a female expert in the intellectual and medical history of this period. Isaacs was one of the most influential British psychologists of the inter-war era, yet historical research on her work is still limited. The article focuses on her writing as ‘Ursula Wise’, answering the questions of parents and nursery nurses in the popular journal Nursery World, from 1929 to 1936. Researched in depth for the first time, Isaacs’ important magazine columns reveal that her writing was instrumental in disseminating the work of psychoanalyst Melanie Klein in Britain. Moreover, Isaacs’ powerful rebuttals to behaviourist, disciplinarian parenting methods helped shift the focus of caregivers to the child’s perspective, encouraging them to acknowledge children as independent subjects and future democratic citizens. Like other early psychoanalysts, Isaacs was not an elitist; she was in fact committed to disseminating her ideas as broadly as possible. Isaacs taught British parents and child caregivers to ‘speak Kleinian’, translating Klein’s intellectual ideas into ordinary language and thus enabling their swift integration into popular discourse. PMID:28901872

  17. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-09-01

    In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  18. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-12-01

    Full Text Available In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  19. Interview with Dr. Damian Milton

    OpenAIRE

    Milton, Damian

    2016-01-01

    Dr Damian Milton is one of the pre-eminent thinkers and presenters in the autism field in the UK and is gaining an increasing reputation internationally. He is a member of the scientific and advisory committee of Research Autism and is Head of Autism Knowledge and Expertise at the National Autistic Society. Damian is also a researcher for London South Bank University. He has worked on a number of projects for the Autism Education Trust, as well as autistic-led ventures such as the Theorising ...

  20. Diasporic Reconciliations of Politics, Love and Trauma: Susan Abulhawa’s Quest for Identity in Mornings in Jenin

    Directory of Open Access Journals (Sweden)

    Ayman M Abu-Shomar

    2015-04-01

    Full Text Available Negotiating human conditions is an emblematic critical impetus of diaspora informed by multiple cultural possibilities practiced through the creation of multiple spaces that cross the realm of the ‘self’ to that of the ‘other’. It offers a locale to cross from the oppressed ‘self’ to an understanding of an oppressor ‘other’. Yet, diasporic negotiation is politically involved in the most responsible manner; it engages the contextual social realities in order to enable creative possibilities for overcoming the logic of the politics altogether. It invites a kind of political involvement that assures the ‘situatedness of the ethical’ in a framework of moral humanistic realisations. The realisation of diasporic negotiations is dialogically engaged in manners that will give birth to new possibilities for human togetherness. In this essay, I trace the signs of diasporic negotiations of politics, love and trauma in Susan Abulhawa’s Mornings in Jenin by focusing on the Diasporic identity of Amal (the central character. I consider the intersections between diaspora, dislocation of identity and the creation of negotiating spaces that qualify an 'epistemology of Diaspora' against essentialised and ethnocentric construction of realities. I argue that Abulhawa creates diasporic spaces and immense moral scenes to transcend a particular stance of politics via transcending love in opposition to suffering and tribulation. I contend that Abulhawa’s conceptualisation of Diasporic negotiations enables her to depict and gauge two extreme human sentiments: love and trauma, yet, without yielding or compromising the right of just resistance and dissent. Keywords: Diaspora, humanism, Trauma, identity, negotiating difference, and 'Otherness'

  1. Dr House, TV, and reality...

    Science.gov (United States)

    Lapostolle, Frédéric; Montois, Sylvie; Alhéritière, Armelle; De Stefano, Carla; Le Toumelin, Philippe; Adnet, Frédéric

    2013-02-01

    Medical practice in the media is usually far from reality. Thus, the viewer may be led astray. The world-famous fictional Dr House has to face a difficult diagnosis every week. His practice does not seem to reflect reality. The aim of this study was to assess the diagnosis strategy involved in this television program. An observer has previewed the 2011 season. The episode running time, the patient's age and sex, the list of all investigations and interventions, the final diagnosis, and the patient's outcome were collected. Number and proportion of French viewers for each episode were recorded. We analyzed 18 episodes. The median running time was 42.5 (42.1-43.2) minutes. Main patient characters were 12 men (66%) and 6 women (33%); the average age was 31 (22-38) years. There were 225 investigations or interventions reported, averaging 14 (9-15) per episode, representing one examination every 3.1 (2.9-4.8) minutes. The most frequently prescribed investigations were magnetic resonance imaging (MRI; 13; 72%), blood sample (11; 61%), and biopsy (10; 56%). The most frequent interventions were surgery, anti-infectious treatments, and steroid treatments (9 each; 50%). Two patients (11%) died. The median number of spectators was 8.4 (8.1-8.7) million, corresponding to 33% (33%-34%) of the French national audience. The population and the examination strategies used by Dr House were unrealistic. Because of this distortion, patients may not understand, nor accept the delay, the investigation choices, the intervention costs, risks, nor failures of a daily medical practice. Physicians should be aware of this "information bias." Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Dr. von Braun Briefing Walt Disney

    Science.gov (United States)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  3. In Memoriam: Dr. Frank John Fenner

    Centers for Disease Control (CDC) Podcasts

    2011-04-22

    This podcast reflects on one of the greatest pioneers in virology, Dr. Frank John Fenner. Dr. Frederick Murphy, a member of EID's editorial board and the Institute of Medicine, and professor of Pathology at the University of Texas Medical Branch in Galveston, shares professional and personal stories of Dr. Frank Fenner.  Created: 4/22/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/26/2011.

  4. Vozvrashtshenije "Ekzorsista" / Susan Howard

    Index Scriptorium Estoniae

    Howard, Susan

    2001-01-01

    William Friedkini 1973.a. valminud õudusfilm "Exorcist", selle järjed ja selle hiljuti restaureeritud ja taas ekraanile paisatud versioon ning nende mõju näitlejanna Linda Blair'i elukäigule, kes filmis mängis saatanast vaevatud teistmelist

  5. dr. andries albertus odendaal snr., evangeliedraer in

    African Journals Online (AJOL)

    sy tesis wat na Nederland gepos word nie. Deur middel van 'n vriend is by Dr. Bergema navraag gedoen hieroor. Dit blyk dat Dr. Bergema ewe ontsteld was omdat A.A. nie reageer op sy briewe en aanbevelings nie. Dringende navraag by die plaaslike poskantoor en hulle ondersoek het aan die lig gebring dat die.

  6. Dr Andrea Granelli, Vice President, Telecom Italia

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 06: Dr Andrea Granelli, Chief Executive Officer, Telecom Italia Lab (second from right) visiting the LHC superconducting magnet test hall with (from left to right) M. Cecchi , F. Gagliardi and G. Cavallari. Photo 15: Dr Andrea Granelli, Chief Executive Officer, Telecom Italia Lab (left) visiting the LHC superconducting magnet test hall with (from left to right) M. Cecchi and G. Cavallari.

  7. Dr. Zakir Husain on Education and Language

    Science.gov (United States)

    Kumar, Deepak; Radha Gayathri, Ch.

    2017-01-01

    Dr. Zakir Husain is known as a self-less nationalist leader and also as an educationist "par excellence." Taking a cue from his educational ideas like the "Nai Talim," this article brings into focus his views on the medium-conundrum. Dr. Husain was very clear about the role of Indian languages and the relevance of mother…

  8. Interview with Dr. Claudio Rama

    Directory of Open Access Journals (Sweden)

    Claudio Rama

    2016-05-01

    Full Text Available Trayendo un breve curriculum vitae del Prof. Dr. Claudio Rama, destacaremos su formación académica, su trayectoria académico-profesional y su producción bibliográfica. Nuestro entrevistado se graduó en Economía por la Universidad Central de Venezuela en 1982. En 2003 concluyó el máster en Administración Educacional en la Universidad José María Vargas, Venezuela. Terminó el Doctorado en Ciencias de la Educación en la Universidad Nacional Experimental Simón Rodríguez, Venezuela en 2006 y el Doctorado en Derecho, en la Universidad de Buenos Aires, en 2009. Claudio Rama hizo pos-doctorado: en el Centro de Postgrados de la Universidad Nacional Experimental Simón Rodríguez, en 2009-2010; en el Programa de Posgrado de la Faculdade de Educação da UNICAMP, en 2009-2010; en el Programa de Posgrado de la Universidade Federal Fluminense, en 2011-2012; y en el Programa de Postdoctorado de la Facultad de Derecho, de la Universidad de Buenos Aires, en 2013-2015. Nuestro entrevistado recibió también el título de Doctor “honoris causa” de cuatro universidades peruanas.

  9. Association between HLA-DR1 and -DR3 antigens and unexplained repeated miscarriage

    DEFF Research Database (Denmark)

    Christiansen, O B; Ring, Mette; Rosgaard, A

    1999-01-01

    Few, mostly small, studies have investigated the distribution of HLA class II antigens among women with unexplained recurrent miscarriage. Although some studies have reported statistically significant associations between this syndrome and certain HLA-DR antigens--especially the -DR1 and -DR3...... antigens--other studies have been unable to demonstrate such associations. For the present meta-analysis, 18 cross-sectional or case-control studies (published or unpublished) reporting on frequencies of HLA-DR1 and -DR3 antigens among Caucasian women with unexplained repeated miscarriage were identified...

  10. Dennis C. Roberts & Susan R. Komives (Eds. (2016. Enhancing Student Learning and Development in Cross-Border Higher Education. San Francisco: Jossey-Bass.

    Directory of Open Access Journals (Sweden)

    Munita Dunn-Coetzee

    2017-07-01

    Full Text Available Enhancing Student Learning and Development in Cross-Border Higher Education, edited by Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation’s Education City in Doha in 2010. This partnership challenged the way in which higher education internalisation was viewed – in such a way that the visit was replicated in 2012 and this book was authored.

  11. Association between HLA-DR1 and -DR3 antigens and unexplained repeated miscarriage

    DEFF Research Database (Denmark)

    Christiansen, O B; Ring, Mette; Rosgaard, A

    1999-01-01

    Few, mostly small, studies have investigated the distribution of HLA class II antigens among women with unexplained recurrent miscarriage. Although some studies have reported statistically significant associations between this syndrome and certain HLA-DR antigens--especially the -DR1 and -DR3...... antigens--other studies have been unable to demonstrate such associations. For the present meta-analysis, 18 cross-sectional or case-control studies (published or unpublished) reporting on frequencies of HLA-DR1 and -DR3 antigens among Caucasian women with unexplained repeated miscarriage were identified...... and because patients with only two miscarriages were included in many studies; this is defined as repeated miscarriage. The odds ratios of repeated miscarriage for the HLA-DR1 and -DR3 antigens were calculated for the individual studies and subsequently the pooled odds ratios for the studies were calculated...

  12. Letter to Dr. Felix Bronner

    Science.gov (United States)

    Greenleaf, John E.; Dalton, Bonnie (Technical Monitor)

    2002-01-01

    Dear Dr. Bronner: I have been reading in The Physiologist the letters from senior physiologists for many years with great interest. It is impressive that many of the respondents are still pursuing scientific endeavours in their 70's and some even in their 80's. The interesting task is to ponder the relative causative proportions of heredity and environment responsible. One wonders whether knowing something about physiology engenders longer and more productive lives? I suspect so because of the accompanying self-discipline. But another factor would seem to be the pervasive joy of working in this profession. I have been fortunate to be able to acquire the joy of physiology during my graduate studies at Illinois, and to have been able to carry it over here at NASA, Ames Research Center for the past 40 years. A truly academic style research environment at a federal research center is rare. The trick to a joyous research career is to overcome those ever-present slings and arrows of outrageous fortune with dignity whenever possible. To that end I have found solace and guidance in reading the history of warfare and its leaders, especially Sun Tsu's The Art of War and Clauswitz's On War. I became eligible for retirement in 1993, but to insure domestic tranquility and also the joy of pursuing my research hobby have continued working in the laboratory on human research. It is troubling to see that funding for individual scientists conducting human research is declining rapidly, along with their new ideas; perhaps the old ones are more comfortable. Hopefully I can provide a similar response when I'm 80! Thanks for your interest. Sincerely, John Greenleaf

  13. An Interview with Dr. Walter Lear

    Directory of Open Access Journals (Sweden)

    The Editors

    2009-03-01

    Full Text Available In this issue of the English version of Social Medicine we are publishing the first of several pamphlets loaned to us by the US Health Activism History Collection. To introduce this collection we travelled to Philadelphia on June 18, 2008 to interview Dr. Walter J. Lear. Dr Lear, born in 1923, is the person responsible for the collection. In a wide-ranging interview in his home Dr. Lear discussed his personal background, the origins and purpose of the collection, the impact of the McCarthy period on the US health left, as well as his vision for the future.

  14. But Dr. Meisels Is Not Convinced.

    Science.gov (United States)

    Meisels, Samuel J.

    1987-01-01

    Commenting on the Gesell Institute's response to his original article concerning the Gesell assessments, Dr. Meisels continues to maintain that the Gesell readiness tests lack sufficient proof of validity. (BB)

  15. Dr. Irvin Yalom Discusses Group Psychotherapy.

    Science.gov (United States)

    Forester-Miller, Holly

    1989-01-01

    In this interview, Dr. Irvin Yalom, director of the Adult Psychiatry Clinic at Stanford University School of Medicine, discusses his beginnings as a group psychotherapist, current issues in group work, and the future of group work. (Author/TE)

  16. Raghavarao, Dr Karumanchi Srisaila Mallikarjuna S

    Indian Academy of Sciences (India)

    Elected: 2014 Section: Engineering & Technology. Raghavarao, Dr Karumanchi Srisaila Mallikarjuna S Ph.D. (Mumbai), FNAE, FNAAS. Specialization: Food Engineering, Biotechnology Address: Chief Scientist, Department of Food Engineering, Central Food Technological Research Institute, Mysore 570 020, Karnataka

  17. Dr. von Braun With German Rocket Experimenters

    Science.gov (United States)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  18. Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

    Directory of Open Access Journals (Sweden)

    de Vries Elisabeth GE

    2011-01-01

    Full Text Available Abstract Background rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5. Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed whether agonistic DR4 or DR5 antibodies could be used to circumvent rhTRAIL resistance, alone or in combination with various chemotherapies. Methods Our study was performed in an isogenic model comprised of the SW948 human colon carcinoma cell line and its rhTRAIL resistant sub-line SW948-TR. Effects of rhTRAIL and agonistic DR4/DR5 antibodies on cell viability were measured using MTT assays and identification of morphological changes characteristic of apoptosis, after acridine orange staining. Sensitivity to the different death receptor ligands was stimulated using pretreatment with the cytokine IFN-gamma and the proteasome inhibitor MG-132. To investigate the mechanisms underlying the changes in rhTRAIL sensitivity, alterations in expression levels of targets of interest were measured by Western blot analysis. Co-immunoprecipitation was used to determine the composition of the death-inducing signalling complex at the cell membrane. Results SW948 cells were sensitive to all three of the DR-targeting agents tested, although the agonistic DR5 antibody induced only weak caspase 8 cleavage and limited apoptosis. Surprisingly, agonistic DR4 and DR5 antibodies induced equivalent DISC formation and caspase 8 cleavage at the level of their individual receptors, suggesting impairment of further caspase 8 processing upon DR5 stimulation. SW948-TR cells were cross-resistant to all DR-targeting agents as a result of decreased caspase 8 expression levels. Caspase 8 protein expression was restored by MG-132 and IFN-gamma pretreatment, which also re-established sensitivity to rhTRAIL and agonistic DR4 antibody in SW948-TR. Surprisingly, MG-132 but not IFN

  19. Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5 monoclonal antibody, to inhibit DR5/TRAIL complex formation

    Directory of Open Access Journals (Sweden)

    Qiao Chunxia

    2012-07-01

    Full Text Available Abstract Background As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC and activation of the membrane proximal caspases (caspase-8 or caspase-10 and mitochondrial pathway. Some monoclonal antibodies against DR4 or DR5 have been reported to have anti-tumor activity. Results In this study, we reported a novel mouse anti-human DR5 monoclonal antibody, named as LaDR5, which could compete with TRAIL to bind DR5 and induce the apoptosis of Jurkat cells in the absence of second cross-linking in vitro. Using computer-guided molecular modeling method, the 3-D structure of LaDR5 Fv fragment was constructed. According to the crystal structure of DR5, the 3-D complex structure of DR5 and LaDR5 was modeled using molecular docking method. Based on distance geometry method and intermolecular hydrogen bonding analysis, the key functional domain in DR5 was predicted and the DR5 mutants were designed. And then, three mutants of DR5 was expressed in prokaryotic system and purified by affinity chromatograph to determine the epitope of DR5 identified by LaDR5, which was consistent with the theoretical results of computer-aided analysis. Conclusions Our results demonstrated the specific epitope located in DR5 that plays a crucial role in antibody binding and even antineoplastic bioactivity. Meanwhile, revealed structural features of DR5 may be important to design or screen novel drugs agonist DR5.

  20. Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2013-01-01

    Blogindlæg om Machiavelliske følelser i HBO tv-serien Game of Thrones: "Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones"......Blogindlæg om Machiavelliske følelser i HBO tv-serien Game of Thrones: "Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones"...

  1. Modulation of TRAIL resistance in colon carcinoma cells : Different contributions of DR4 and DR5

    NARCIS (Netherlands)

    van Geelen, Caroline M. M.; Pennarun, Bodvael; Le, Phuong T. K.; de Vries, Elisabeth G. E.; de Jong, Steven

    2011-01-01

    Background: rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed whether

  2. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Photo 01: Dr. David Syz (left) with Professor Roger Cashmore, Research Director for Collider Programmes.Photo 02: Dr. David Syz signing the VIP visitors' book, with Prof. Roger Cashmore.Photo 03: Dr. David Syz signing the VIP visitors' book.Photo 04: Handshake between Dr. David Syz (left) and Prof. Roger Cashmore.

  3. A Tribute to Dr. Willy Lens

    Directory of Open Access Journals (Sweden)

    Maarten Vansteenkiste

    2016-07-01

    Full Text Available Dr. Willy Lens, born on December 10th, 1943, passed away on August 29th, 2014. With his passing, the motivation community has lost a seminal member, a mentor, and a friend. Dr. Lens – a Fellow of the Association for Psychological Science and Founding Fellow of the American Educational Research Association – made fundamental contributions to the study of motivation both through his own work and through his caring and thoughtful mentorship of a large community of scholars. With this tribute, we want to honor Dr. Willy Lens’ significance to psychology and education as well as his positive influence, both personally and professionally, on the lives of dozens of scholars. With his contagious enthusiasm and caring mentorship, Willy was an example for our academic community and with this tribute we express our gratitude for the privilege to have collaborated with him.

  4. Biography of Dr. Simao Nascimento de Sousa

    Digital Repository Service at National Institute of Oceanography (India)

    Sarkar, A.^red.

    International 32 (2006) 148 www.elsevier.com/locate/envint The International workshop on marine pollution and ecotoxicology (2004) was organized to felicitate our colleague Dr. Sima˜o Nascimento de Sousa, Deputy Director, NIO who superannuated on 29th February..., 2004. Dr. de Sousa was born on the 26th of February, 1944 at Corlim, Ilhas, Goa. He graduated with BSc (Hons.) in 1969 and MSc with Physical Chemistry in 1971 from the University of Bombay (Mumbai), India. He began his career with studies in the Mandovi...

  5. Prasada Rao, Dr Turaga Sundara Rama

    Indian Academy of Sciences (India)

    Elected: 1994 Section: Engineering & Technology. Prasada Rao, Dr Turaga Sundara Rama Ph.D. (Andhra), FNAE. Date of birth: 20 January 1939. Specialization: Petroleum Refining and Heterogeneous Catalysis Address: SFS Flat No. 600, DDA/HIG Flats, Sector 13, Phase 2, Pocket B, Dwaraka, New Delhi 110 045, U.T.

  6. The Contributions of Dr. Alfred Gysi.

    Science.gov (United States)

    Phoenix, Rodney D; Engelmeier, Robert L

    2016-11-24

    This article is a historical overview of Dr. Alfred Gysi's contributions to the profession in the areas of denture tooth and articulator design. His understanding of occlusion and mandibular movement resulted in denture tooth designs and occlusal concepts still in widespread use. © 2016 by the American College of Prosthodontists.

  7. The Years of Dr. Robert Eugene Marshak

    Science.gov (United States)

    Mo, Luke W.

    I am honored and privileged to make a brief statement in memory of Dr. Marshak's distinguished achievement in science, his kindness and great humanity. I will concentrate on the part of his career at Virginia Polytechnic Institute and State University …

  8. Prof Dr.Farida Habib Shah

    Indian Academy of Sciences (India)

    ranjeetha

    Women in Leadership Roles in Science. dR h Pl i th L k Pi li ... Employment – job entry. M i th l dd. • Moving up the ladder. • Decision making committees. • Leadership Positions. • Women in Technopreneurship- corporate level .... Organize more training programmes for communication and presentation skills for their ...

  9. Dr Tedros Adhanom: New WHO Director General

    African Journals Online (AJOL)

    2017-08-03

    Aug 3, 2017 ... five other candidates to the post. His accomplishments both in Ethiopia and the global stage catapult him to this remarkable success. ... Dr Tedros is a change agent, and a reformist in the health sector. His election as the Director General of WHO brings along a lot of expectations for a better health agenda ...

  10. In Memoriam- Prof. Dr. Andries Willem Lategan

    Directory of Open Access Journals (Sweden)

    S. P. Ligthelm

    1965-03-01

    Full Text Available Hierdie Curriculum Vitae sou voorgelees gewees het met die inougurele rede van wyle prof. dr. A. W. Lategan met die aanvaarding van 'n ereprofessoraat aan die P.U. vir C.H.O. op 29 Oktober 1965. Prof. Lategan is op 23 Oktober 1965 oor- lcde. Sy inougurele rede verskyn as ’n bylaag in hierdie uit- gawe.

  11. Stop words for “Dr Math”

    CSIR Research Space (South Africa)

    Butgereit, L

    2011-05-01

    Full Text Available “Dr Math” is a facility where primary and secondary school pupils can use MXit on their cell phones to get help with their mathematics homework. Pupils use an abbreviated “MXit lingo” leaving out most vowels and substituting various numerals...

  12. The great neurosis of Dr. Joseph Gerard.

    Science.gov (United States)

    Lefrère, Jean-Jacques; Rouillon, Frédéric

    2013-01-01

    The Great Neurosis, of Dr. Joseph Gerard, was published in 1889 in Paris. The book, intended for the general public, shows the different varieties of neuroses through picturesque and instructive examples. Its scientific and medical value is poor, but provides us with the various meanings of the word 'neurosis' in the late nineteenth century. Copyright © 2013 S. Karger AG, Basel.

  13. Confessions of a Dr Math tutor

    CSIR Research Space (South Africa)

    Butgereit, L

    2015-06-01

    Full Text Available Mathematics look different on a small 3-inch screen of an inexpensive cell phone when compared to a 3-meter whiteboard in a mathematics classroom. Dr Math uses cell phone or mobile data "chat" technologies to assist primary and secondary school...

  14. Decommissioning of DR 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lauridsen, Kurt

    2006-01-15

    The report describes the decommissioning activities carried out at the 2kW homogeneous reactor DR 1 at Risoe National Laboratory. The decommissioning work took place from summer 2004 until late autumn 2005. The components with the highest activity, the core vessel the recombiner and the piping and valves connected to these, were dismantled first by Danish Decommissioning's own technicians. Demolition of the control rod house and the biological shield as well as the removal of the floor in the reactor hall was carried out by an external demolition contractor. The building was emptied and left for other use. Clearance measurements of the building showed that radionuclide concentrations were everywhere below the clearance limit set by the Danish nuclear regulatory authorities. Furthermore, measurements on the surrounding area showed that there was no contamination that could be attributed to the operation and decommissioning of DR 1. (au)

  15. Prof dr FJ van Zyl as sendingteoloog

    Directory of Open Access Journals (Sweden)

    D. J.C. vanWyk

    1989-01-01

    Full Text Available Prof Dr FJ van Zyl as mission theologian In this article, the theology of mission of Prof dr FJ van Zyl is being explored. This is done by way of his lectures in the Science of Mission at the University of Pretoria during 1960-1978 and also from articles in the magazines of the Nederduitsch Hervormde Kerk dating back approximately forty years. It is found that almost none of his dictions is outdated. The radical cataclysm in the theology of mission, especially after 1961, he sharply detected and exposed. His theology of mission is built on a very broad theological base which can be described as theology of the Word. To him mission is proclamation.

  16. On the trail of Dr. Fifer.

    Science.gov (United States)

    Asche, G

    1996-05-01

    A gift from a patient drew Hope, BC, family physician Gerd Asche irrevocably into the local medical history of the 1858 Fraser River Gold Rush. Because of his interest in Dr. Max William Fifer, Asche undertook research missions in British Columbia, England and the US, converted his computer room to a research and writing centre, and wrote a biography of his predecessor and colleague. He recounts his experience and the growing satisfaction provided by his interest in medical history.

  17. On the trail of Dr. Fifer.

    OpenAIRE

    Asche, G

    1996-01-01

    A gift from a patient drew Hope, BC, family physician Gerd Asche irrevocably into the local medical history of the 1858 Fraser River Gold Rush. Because of his interest in Dr. Max William Fifer, Asche undertook research missions in British Columbia, England and the US, converted his computer room to a research and writing centre, and wrote a biography of his predecessor and colleague. He recounts his experience and the growing satisfaction provided by his interest in medical history.

  18. [Homage to Professor Dr. Nicasio Etchepareborda].

    Science.gov (United States)

    1998-11-01

    During a solemn academic act, de Main Classroom of the Facultad de Odontologia de Buenos Aires was named after Prof. Dr. Nicasio Etchepareborda. He has been the first professor at the Escuela de Odontologia and its organizer, after having obtained his Dentistry degree at the Dental School of Paris, in 1882. The new school was founded in 1891, and its activities began the following year.

  19. Dr. William C. Harris, Director-General, Science Foundation Ireland

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 01: Dr William C. Harris, Director-General, Science Foundation Ireland (left) with R. Cashmore. Photos 02, 03: Dr William C. Harris, Director-General, Science Foundation Ireland signing the CERN guest book with R. Cashmore.

  20. Dr. Ziya Kirkali: Managing BPH (Benign Prostatic Hyperplasia)

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: Prostate Enlargement Dr. Ziya Kirkali: Managing BPH Past Issues / Winter 2017 ... Articles Treating the Problem Prostate / Understanding Prostate Enlargement / Dr. Ziya Kirkali: Managing BPH Winter 2017 Issue: Volume ...

  1. Gaia DR1 documentation Chapter 6: Variability

    Science.gov (United States)

    Eyer, L.; Rimoldini, L.; Guy, L.; Holl, B.; Clementini, G.; Cuypers, J.; Mowlavi, N.; Lecoeur-Taïbi, I.; De Ridder, J.; Charnas, J.; Nienartowicz, K.

    2017-12-01

    This chapter describes the photometric variability processing of the Gaia DR1 data. Coordination Unit 7 is responsible for the variability analysis of over a billion celestial sources. In particular the definition, design, development, validation and provision of a software package for the data processing of photometrically variable objects. Data Processing Centre Geneva (DPCG) responsibilities cover all issues related to the computational part of the CU7 analysis. These span: hardware provisioning, including selection, deployment and optimisation of suitable hardware, choosing and developing software architecture, defining data and scientific workflows as well as operational activities such as configuration management, data import, time series reconstruction, storage and processing handling, visualisation and data export. CU7/DPCG is also responsible for interaction with other DPCs and CUs, software and programming training for the CU7 members, scientific software quality control and management of software and data lifecycle. Details about the specific data treatment steps of the Gaia DR1 data products are found in Eyer et al. (2017) and are not repeated here. The variability content of the Gaia DR1 focusses on a subsample of Cepheids and RR Lyrae stars around the South ecliptic pole, showcasing the performance of the Gaia photometry with respect to variable objects.

  2. Dr. Norman Bethune as a surgeon.

    Science.gov (United States)

    Rosen, I B

    1996-02-01

    Dr. Norman Bethune's recognition as a Canadian of renown resulted from his devoted work in China during the late 1930s. He had received a general surgical training, but his personal illness with tuberculosis led him to specialize in thoracic surgery. A surgical program at McGill University under Dr. Edward Archibald, a pioneer thoracic surgeon, was initially successful, but by the mid-1930s Bethune was rejected by McGill and Dr. Archibald. He became chief of thoracic surgery at the Hôpital du Sacré-Coeur outside Montreal. H developed thoracic surgical instruments and wrote numerous scientific papers. The outbreak of civil war in Spain in 1937 attracted Bethune to oppose what he viewed as fascist aggression. He went to Spain, where he established the value of mobile blood banking. On his return to Canada in 1937 he became aware of the escalating war between China and Japan. He joined the Chinese communist forces in northern China and spent 18 months doing Herculean mobile war surgery, while improving the state of medical services in primitive, depressing conditions. He died in 1939 at the age of 49 years of septicemia as a result of accidental laceration of his finger during surgery. The Chinese have venerated Norman Bethune and stimulated his memorialization in Canada. His surgical record can be viewed as mixed in quality, but overall his performance remains impressive for its achievement.

  3. HLA-DR expression and disease activity in ulcerative colitis

    DEFF Research Database (Denmark)

    Poulsen, L O; Elling, P; Sørensen, Flemming Brandt

    1986-01-01

    -DR antigens on rectal epithelial cells of patients with UC could not be predicted from the clinical, rectoscopic, or histologic findings. HLA-DR expression is normally restricted to immunocompetent cells. The presence of HLA-DR antigens on epithelial cells may be a consequence of immunological reactions...

  4. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland, toured the assembly hall of the ATLAS experiment on a recent visit to CERN.Photos 01, 02: Dr. Peter Jenni, spokesperson for the ATLAS experiment (second from left), explains to Dr. David Syz (fourth from left) and accompanying visitors the process of integration of a 26-metre-long coil of the barrel toroid magnet system into its coil casing.Photo 03: Dr. Peter Jenni (extreme right) with Dr. David Syz (front row, fourth from right) behind a stack of 26-metre-long 'racetrack' coils awaiting integration into their coil casings.

  5. Boodskap van Professor Dr. J. Waterink

    Directory of Open Access Journals (Sweden)

    J. Waterink

    1955-03-01

    Full Text Available Boodskap van Professor Dr. J. Waterinkter gelegendheid van die verlening aan hem van de graad Doctor Educationis, honoris causa, door de Universiteit voor Christelijk Hoger Onderwijs te Potchefstroom op Zaterdag, 26 Maart 1955, en op die dag voorgelezen door de heer Jan van den Berg, Buitengewoon en Gevolmachtigd Ambassadeur van Hare Mi iesteit de Koningin der Nederlanden. Mijnheer, de Kanselier, Mijnheer de Voorzitter van de Raad, Mijnheer deVice-Kanselier en Rector, overige Heren ambtsdragers, en gij alien,die herwaarts kwaanit ter gelegenheid van deze Gradendag,zeer geachte en zeer gewenste toehoorders.

  6. Interview with a quality leader. Linda Aiken on the healthcare industry and workplace issues. Interview by Susan V. White and Colleen J. Hewes.

    Science.gov (United States)

    Aiken, Linda

    2003-01-01

    Linda Aiken, PhD MSN, is director of the Center for Health Outcomes and Policy Research and The Claire M. Fagin Leadership Professor of Nursing and Professor of Sociology at the University of Pennsylvania in Philadelphia. Dr. Aiken's other appointments at the University of Pennsylvania include senior fellow at the Leonard Davis Institute for Health Economics and research associate in the Population Studies Center. Before joining the University of Pennsylvania faculty in 1988, Dr. Aiken served as vice president of the Robert Wood Johnson Foundation. She is a member of the Institute of Medicine, a fellow of the American Academy of Arts and Sciences and of the National Academy of Social Insurance, a former president of the American Academy of Nursing, a distinguished fellow of the Academy for Health Services Research and Health Policy (now AcademyHealth), and a member of the Council on the Economic Impact of Health System Change. Dr. Aiken served on the Medicare Physician Payment Review Commission for 6 years and was a member of the 1982 Social Security Advisory Council and of President Clinton's National Health Reform Task Force. Her recent work, for which she received the Sigma Theta Tau International Clinical Research Award in 1999, has focused on accounting for variation in hospital patient outcomes in the United States, Canada, the United Kingdom, and Germany. Dr. Aiken received her bachelor's and master's degrees in nursing from the University of Florida, Gainesville, and her doctorate in sociology and demography from the University of Texas at Austin.

  7. Interview with a quality leader: Kent Bottles, MD, president of ICSI, on transforming care for the future. Interview by Susan V. White.

    Science.gov (United States)

    Bottles, Kent

    2010-01-01

    Kent Bottles, MD, President of the Institute for Clinical Systems Improvement (ICSI). Dr. Bottles is a board-certified pathologist who specialized in surgical and cyto-pathology. He earned a medical degree from Case Western Reserve University in Ohio. He has extensive experience in integrated healthcare delivery systems, research, academia, commercial laboratories, genomics, proteomics, and management of biotech start-up companies. Dr. Bottles was vice president and chief medical officer of the Iowa Health System. Before that, he served as president and CEO of Grand Rapids Medical Education and Research Center for Health Professions, a multi-institutional consortium of healthcare organizations, and as president of Genomics Repository and chief knowledge officer, Genomics Collaborative Inc. Dr. Bottles has extensive academic experience, serving as Professor and Acting Head, Department of Pathology and Laboratory Medicine at the University of Iowa. He was also the founding medical director of managed care plans for University of Iowa employees. Dr. Bottles has addressed topics ranging from quality and patient safety and disruptive technology to patient-physician relationships and the future of medicine. He has received numerous honors, including the Rodney T. West Literary Achievement Award for the most important article on medical management presented by the American College of Physician Executives. He has broad clinical experience with the University of Iowa and the San Francisco General Hospital, and has been a national leader in changing the practice of pathology and laboratory medicine to meet the challenges of managed care.

  8. Dr. Seuss Is on the Loose! Planning Month-Long Activities Using Dr. Seuss Materials.

    Science.gov (United States)

    Tuten-Puckett, Katharyn

    This paper contains activities for classes and small groups using 24 Dr. Seuss stories. The rhymes and illustrations can spark creative writing and inspire imaginative bulletin board displays. The ideas and activities presented are useful with most elementary grades by making adjustments for student abilities. Many of the titles contain political…

  9. "If you thought this story sour, sweeten it with your own telling" - a feminist poetics of rewriting in Susan Price's Ghost dance

    Directory of Open Access Journals (Sweden)

    Sanna Lehtonen

    2010-01-01

    Full Text Available The attempts to challenge conventional gendered discourses in children's fantasy have often resulted in feminist rewritings of earlier stories. Ghost dance (1994 by the English author Susan Price is a novel that reflects a specific feminist poetics of rewriting: metafictional passages highlight the constructedness of the narrative and at the end readers are invited to tell their own versions of the story. Moreover, the rewriting freely combines and recontextualises elements from different source texts and reformulates them to create a narrative that challenges conventional discourses of gender. While this poetics has an appeal from a feminist perspective, the play with cross-cultural intertexts and gender becomes more complex when the novel is examined in a postcolonialist framework in relation to ethnicity and the issue of cultural appropriation. Ghost dance is situated in a setting that has a real-world equivalent (Russia, involves characters that are identified with names of real-world ethnic groups (Lapps (Sámi, Russian, and mixes elements from Russian wonder tales, Nordic mythology and an Ojibwe legend. The novel does not aim at historical accuracy in its representations nor is it a direct retelling of any of the pre-texts but combines motifs, themes, names, characters and settings freely from each source. In this textual melting pot, the protagonist Shingebiss is, on one level, a revision of the witch Baba Yaga, but also described as a Lappish shaman with an Ojibwe name. To rewrite gendered discourses, certain elements from the pretexts are chosen and others left out – the question is, then, what effects does this recontextualisation have on the representation of ethnicity? Or, are the feminist rewriting strategies actually a form of cultural appropriation?

  10. Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

    CERN Document Server

    Patrice Loiez

    1999-01-01

    Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

  11. VIP Visit Her Excellency Dr Dalia Grybauskaite

    CERN Multimedia

    2016-01-01

    Her Excellency Dr Dalia Grybauskaite President Republic of Lithuania. Wednesday 20 January 2016. General introduction to CERN’s activities by CERN Director-General F. Gianotti. CERN Director-General introduces CMS Collaboration Deputy Spokesperson K. Borras and CMS Lithuanians A. Rinkevicius with V. Rapsevicius. Met by J. Shiers, IT Department Data Preservation Project Leader, and walk to 1st floor Data Centre Visit Point. CERN Data Centre Visit Point, 1st floor, building 513. View the robotic arms of the CERN IT data centre automated libraries (J. Shiers) CERN Computer Centre, building 513, level -1. Physics hands-on and virtual visit with a High School class in Lithuania (S. Schmeling) CERN S’cool Lab, building 143. Meeting with the Lithuanian community at CERN. Signature of the Guest Book with CERN Director-General witnessed by the Lithuanian community at CERN. Family photograph with the Lithuanian community at CERN.

  12. Dr. Solco Tromp and the Tromp Award

    Science.gov (United States)

    Greene, J. Scott; Rietveld, Wop J.

    2017-09-01

    The Tromp Award is the highest honor awarded by the International Society of Biometeorology (ISB). The award acknowledges outstanding research in biometeorology by a scientist under the age of 35 and was established in conjunction with the Tromp Foundation and the ISB. In honor of the 60th anniversary of the ISB, this article will provide a brief summary of the life of Dr. Solco Tromp and of the six awardees of the Tromp Award since the inaugural issuance of the award in 1999. The Tromp Award was established in part to recognize and support the efforts of young biometeorological professionals. As the brief summary of the awardees and a few of their selected subsequent publications have shown, the ISB and the Tromp Award has proven effective at identifying and supporting promising young scientists.

  13. Decommissioning of DR 2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Strufe, N.

    2009-02-15

    This report describes the work of dismantling and demolishing reactor DR 2, the waste volumes generated, the health physical conditions and the clearance procedures used for removed elements and waste. Since the ultimate goal for the decommissioning project was not clearance of the building, but downgrading the radiological classification of the building with a view to converting it to further nuclear use, this report documents how the lower classification was achieved and the known occurrence of remaining activity. The report emphasises some of the deliberations made and describes the lessons learned through this decommissioning project. The report also intends to contribute towards the technical basis and experience basis for further decommissioning of the nuclear facilities in Denmark. (au)

  14. [Dr. John Baptiste Edouard Gélineau].

    Science.gov (United States)

    Janković, S; Susić, V; Sokić, D; Lević, Z

    1996-01-01

    With this brief review we honor the memory of the great French doctor Jean Baptiste Edouard Gélineau. Dr. Gélineau was born on December 23, 1828 at Blaye, Gironde, close to the Bordeaux region. His name is connected with the first clinical description of the disease for which he, both by the right of the primacy as well as ad valorem of his first two names, coined the name "narcolepsy". He was the first to notice the intrinsically evanescent symptoms of narcolepsy, such as excessive daytime somnolence, imperative sleep habits and cataplexy or "astasia" as he called it, and incorporate them into a single clinical syndrome. In 1881 Gélineau discussed Kaffe's case of "maladie du sommeil" as a proof of the existence of the new disease described a year before. As a good clinical observer Gélineau noticed the close relation of emotional engagement and astasia. His attitude was that narcolepsy was a nosologic entity, a disease sui generis, but admitted that it could appear purely as a symptom only. This was in discordance with the views in England where (in 1928) Dr. Samuel Alexander Kinnier Wilson repudiated such convictions; in 1930 Lhermitte still shared the same opinion. Gélineau differentiated narcolepsy from epilepsy with the elegance of clinical reasoning. Overall, Gélineau described three elements of the narcoleptic pentade. Sleep paralyses were first described by Mitchell in 1876, and were first attributed to narcolepsy by Wilson in 1928; in 1930 Lhermitte first described hypnapompic, and Daniels, in 1934, hypnagogic sleep paralysis. Hypnagogic hallucinations were described by Maury in 1848 and subsequently by de Saint Denis in 1867. In twenties they were thoroughly studiesed during the epidemic encephalitis and after the Big War in 1922 by Levy. The life story of Dr. Gélineau covers multivarious activities. As a young student of the Rochefort Navy Medical School he took part in the fight against colera which deluged the city of La Rochelle. In 1849 he

  15. HLA-DR expression and disease activity in ulcerative colitis

    DEFF Research Database (Denmark)

    Poulsen, L O; Elling, P; Sørensen, Flemming Brandt

    1986-01-01

    In 12 patients with active ulcerative colitis (UC) the rectal epithelial cells were analyzed for HLA-DR antigens by an immunohistochemical technique. The clinical, rectoscopic, and histologic stages were also determined. The investigations were carried out at the beginning of the study and 2 weeks......-DR antigens on rectal epithelial cells of patients with UC could not be predicted from the clinical, rectoscopic, or histologic findings. HLA-DR expression is normally restricted to immunocompetent cells. The presence of HLA-DR antigens on epithelial cells may be a consequence of immunological reactions...

  16. Idufirma Silicon Valleyta / Susan Adams

    Index Scriptorium Estoniae

    Adams, Susan

    2014-01-01

    Tarkvarafirma Apprenda toodab teenindusplatvormi tarkvara, mis võimaldab klientidel luua ja hoida käigus uusi mobiilseid ja pilvetehnoloogiapõhiseid rakendusi. Oma töötajatele pakub odavaid elamispindu ja madalaid makse

  17. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    Energy Technology Data Exchange (ETDEWEB)

    Moniz, Ernest [U.S. Energy Secretary

    2014-02-03

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  18. Celebrating the Life and Legacy of Dr. John Hope Franklin

    Science.gov (United States)

    Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

    2009-01-01

    Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

  19. Dr Murray's case of ligation of the abdominal aorta - Somerset ...

    African Journals Online (AJOL)

    The reference provided by Dr Rob was to a brief description entitled 'Dr Murray's case of ligature of the abdominal aona', which had appeared in the Annals of che Royal College of Surgeons of England in 1984.2 The original description of this operation is to be found in both the first (1839) and second editions (1850) of ...

  20. Dr. E. Kits van Waveren (1906—1995)

    NARCIS (Netherlands)

    Bas, C.

    1996-01-01

    With the death on 3 September 1995 of Dr. E. Kits van Waveren, the Dutch mycologists lost one of their most prominent, internationally known amateurs, a specialist on the taxonomy of the genus Psathyrella and an ardent collector. Dr. Kits van Waveren, honorary staff member of the Rijksherbarium at

  1. Dr. Praveen Chaudhari named director of Brookhaven National Laboratory

    CERN Multimedia

    2003-01-01

    "Brookhaven Science Associates announced today the selection of Dr. Praveen Chaudhari as Director of the U.S. Department of Energy's Brookhaven National Laboratory. Dr. Chaudhari, who will begin his new duties on April 1, joins Brookhaven Lab after 36 years of distinguished service at IBM as a scientist and senior manager of research" (1 page).

  2. Dr. Albert Carr--Science Educator 1930-2000

    Science.gov (United States)

    Lopez, Leslie

    2013-01-01

    The very first issue of "Educational Perspectives" was published in October of 1962. Dr. Albert Carr wrote one of the inaugural essays on the topic of current developments in science education, and he went on to write several other articles for the journal. This article shares why Dr. Albert Carr's colleagues remember him for his…

  3. Reexamining the Writings of Dr. Seuss To Promote Character Development.

    Science.gov (United States)

    Brown, Dave F.; Varady, Joe

    1997-01-01

    Discusses the use of children's literature by Dr. Seuss in the middle school classroom to help students explore issues of their character and social development, adult expectations, and changes in their personal environment. Discusses themes addressed in selected Dr. Seuss books, and how these can be used as thematic units for classroom…

  4. Ultrahigh-resolution CT and DR scanner

    Science.gov (United States)

    DiBianca, Frank A.; Gupta, Vivek; Zou, Ping; Jordan, Lawrence M.; Laughter, Joseph S.; Zeman, Herbert D.; Sebes, Jeno I.

    1999-05-01

    A new technique called Variable-Resolution X-ray (VRX) detection that dramatically increases the spatial resolution in computed tomography (CT) and digital radiography (DR) is presented. The technique is based on a principle called 'projective compression' that allows the resolution element of a CT detector to scale with the subject or field size. For very large (40 - 50 cm) field sizes, resolution exceeding 2 cy/mm is possible and for very small fields, microscopy is attainable with resolution exceeding 100 cy/mm. Several effects that could limit the performance of VRX detectors are considered. Experimental measurements on a 16-channel, CdWO4 scintillator + photodiode test array yield a limiting MTF of 64 cy/mm (8(mu) ) in the highest-resolution configuration reported. Preliminary CT images have been made of small anatomical specimens and small animals using a storage phosphor screen in the VRX mode. Measured detector resolution of the CT projection data exceeds 20 cy/mm (less than 25 (mu) ); however, the final, reconstructed CT images produced thus far exhibit 10 cy/mm (50 (mu) ) resolution because of non-flatness of the storage phosphor plates, focal spot effects and the use of a rudimentary CT reconstruction algorithm. A 576-channel solid-state detector is being fabricated that is expected to achieve CT image resolution in excess of that of the 26-channel test array.

  5. Dr. Otto "Tiger" Freer: inventor and innovator.

    Science.gov (United States)

    Chittiboina, Prashant; Connor, David E; Nanda, Anil

    2012-08-01

    Every neurosurgeon develops his or her own standard approach to common intracranial pathologies in terms of the order in which different stages are performed and which instruments are used to perform individual tasks. The majority of the basic steps in performing a craniotomy are learned through repetition and practice during residency training. Significant amounts of energy are devoted to mastering technical skills and developing an operative rhythm. What often receives little attention is the historical origin of the instruments that make the work possible. The Freer elevator represents a particularly interesting example. To people unfamiliar with the accomplishments of turn-of-the-century laryngologist Otto "Tiger" Freer, it can be assumed that the name of the instrument in one's hand is simply named for what it can do, that is, to "free" the nasal mucosa from the bony and cartilaginous septum during the transsphenoidal approach. The technique this master surgeon spent his life and career perfecting is now repeated almost daily by skull base neurosurgeons approaching pathologies from the inferior frontal lobe to the foramen magnum. In reviewing his life and work, the authors of this paper discovered an interesting creative process that led to the design of the eponymous instrument. Additionally, they discovered important advances toward the development of the transnasal approach and in our understanding of the anterior skull base. They present a historical perspective on the life and accomplishments of Dr. Freer and the ubiquitous surgical instrument that he invented and popularized.

  6. Gaia DR1 documentation Chapter 3: Astrometry

    Science.gov (United States)

    Hobbs, D.; Lindegren, L.; Bastian, U.; Klioner, S.; Hernandez, J.; Lammers, U.; Bombrun, A.; Mignard, F.; Altmann, M.; Andrei, A.; Davidson, M.; de Bruijne, J. H. J.

    2017-12-01

    This chapter presents the models and processing steps used for Gaia's core solution, namely, the Astrometric Global Iterative Solution (AGIS). The inputs to this solution rely heavily on the basic observables (or astrometric elementaries) which have been pre-processed and discussed in Chapter 2, the results of which have been published in Fabricius et al. (2016). The models consist of reference systems and time scales; assumed linear stellar motion and relativistic light deflection; in addition to fundamental constants and the transformation of coordinate systems. Higher level inputs such as: planetary and solar system ephemeris; Gaia tracking and orbit information; initial quasar catalogues and BAM data are all needed for the processing described here. The astrometric calibration models are outlined followed by the details processing steps which give AGIS its name. The final Section 3.5 represents a basic quality assessment and validation of the scientific results which has also been published in detail in Lindegren et al. (2016). However, the validation of the science products was not restricted to just this, a more independent catalogue consolidation and validation of the science results for Gaia DR1 was also performed and are documented in Chapter 7 and have been published in Arenou et al. (2017).

  7. A Tribute to Prof Dr Da Ruan

    CERN Document Server

    Kerre, Etienne

    2013-01-01

    This volume is a tribute to Professor Dr Da Ruan, who passed away suddenly on July 31, 2011, aged 50. The flood of emails that spread throughout the fuzzy logic research community with the tragic news was testimony to the respect and liking felt for this remarkable man. Da was a hardworking , highly productive scientist who, during his short life, published 35 books and more than 250 research papers in highly ranked journals and conference proceedings. He established two successful conferences, FLINS and ISKE, as well as the international journal, JCIS. This book is a collection of contributions from 88 of Da's academic friends from 47 institutes, presented in 60 chapters and over 70 pictures. A Foreword by Lotfi Zadeh begins Da's story. Section 1 provides an overview of Da's funeral on August 6, 2011. Part II outlines Da’s scientific life, his education, scientific career, publications and keynote talks. Part III presents testimonials by Da's colleagues of academic activities, including guest professorship...

  8. Dr. Martin Luther King, Jr. as Spiritual Leader

    Directory of Open Access Journals (Sweden)

    Andrea Pierce

    2013-09-01

    Full Text Available The purpose of this paper is to explore Dr. Martin Luther King Jr.’s spiritual leadership through his “I Have a Dream” speech. The paper explores the three characteristics of spiritual leadership as posed by Fry’s (2003 spiritual leadership theory: vision, hope/faith and altruistic love. The research draws upon these characteristics through qualitative content analysis of Dr. Martin Luther King Jr.’s “I Have a Dream” speech to illustrate Dr. King’s leadership as that of a spiritual leader. The research advances the spiritual leadership theory by establishing Dr. Martin Luther King Jr. as a spiritual leader. Through the illustration of Dr. King’s spiritual leadership, the characteristics of a spiritual leader are given tangible understanding.

  9. 78 FR 29781 - Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J...

    Science.gov (United States)

    2013-05-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Atomic Safety and Licensing Board Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J. Charbeneau; In the Matter of Detroit Edison Company (Fermi Nuclear...

  10. Ob osemdesetletnici zaslužnega rednega prof. dr., dr. h. c. Mirka Paka

    Directory of Open Access Journals (Sweden)

    Dejan Rebernik

    2016-12-01

    Full Text Available Slavljenca dr. Mirka Paka, ki je 12. novembra 2016 dopolnil osemdeset let, širši geografski javnosti verjetno ni potrebno podrobno predstavljati. S svojim pedagoškim, znanstveno-raziskovalnim, strokovnim in društvenim delovanjem se je uveljavil kot eden vodilnih slovenskih urbanih, socialnih in regionalnih geografov. Odlikuje se z izjemno bogato bibliografijo in mednarodno znanstveno-raziskovalno dejavnostjo. Njegov znanstveni opus obsega več kot 150 znanstvenih razprav, predvsem s področja urbane, socialne in regionalne geografije.

  11. [Dr. Halfdan Mahler's speech in Guatemala].

    Science.gov (United States)

    Mahler, H

    1989-12-01

    A major focus of Dr. Mahler throughout his life has been the war against female discrimination and to reduce the extreme inequalities between men and women. The Latin American Region of IPPF selected the participation of women as its goal for the decade of the 90's. It is known that fertility is inversely related to female education and occupation, and that the poorest homes worldwide are those headed by poor and illiterate women. The number of female-headed households is increasing and in Barbados, Dominica, Honduras, Jamaica, Nicaragua, Panama and Uruguay these have increased by 31% Married women often find that their husbands are the main obstacles to family planning services. Violence against women takes many forms including physical abuse, adolescent pregnancy, psychological and economic stress, the "machismo" syndrome, and having unwanted pregnancies. Latin America and the Caribbean pregnancy and illegal abortion account for the high mortality rates among those 15-19. Men must face the consequences of the socioeconomic conditions that they have created for women. For example if FPP were designed to really reflect a women's perspective such programs would have reached the goals of success. He recommends that IPPF's goal for the Year 2000 will be to have 9 women to each man in Committees of 10. He suggests that changes towards women must begin with the men themselves so that policies and programs reflect these new attitudes. If society wants a less aggressive and materialistic world, then the role of women must be raised so that her contribution can be felt worldwide.

  12. Dr. Steve Thompson, Chief Executive, The Royal Society of New Zealand

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    L. to r.: Dr Austin Ball, Deputy Technical Coordinator, CMS experiment; Dr Roland Horisberger, Paul Scherrer Institute and CERN, CMS experiment; Dr Steve Thompson, Chief Executive, The Royal Society of New Zealand; Dr Michel Della Negra, Spokesman, CMS experiment and Dr Alick Macpherson, Paul Scherrer Institute and CERN, CMS experiment, in the CMS Silicon Tracker assembly hall.

  13. Interview with Dr Ghassan K Abou-Alfa.

    Science.gov (United States)

    Abou-Alfa, G K

    2016-11-01

    Ghassan K Abou-Alfa joined the Gastrointestinal Oncology Service at Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College in New York back in 2001. Dr Abou-Alfa specializes in the treatment of gastrointestinal malignancies. Dr Abou-Alfa received his medical degree from the American University of Beirut, Lebanon, and completed his post-doctoral training at Yale University School of Medicine. His research is dedicated to finding novel therapies and improving the effectiveness of the current therapies for hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer, while continuing to understand the basic mechanisms of the diseases and its therapy. Dr Abou-Alfa has invested several years in helping develop multi-tyrosine kinases and more immune-modulator therapies. Dr Abou-Alfa has many publications in the field. He led on many occasions international teams of investigators. Dr Abou-Alfa serves as the chair of the National Cancer Institute (NCI) Task Force for Hepatobiliary Cancers and the chair of the AIDS Malignancy Consortium (AMC) Non-AIDS Defining Malignancies (NADC) Liver/GI Task Force. Dr Abou-Alfa also co-chairs the hepatobiliary cancers subgroup of the Alliance cooperative group, and is a cadre member of both the gastrointestinal cancers and pharmacogenomics and population pharmacology committees. Dr Abou-Alfa who has lectured worldwide on the subject on gastrointestinal malignancies, is also a strong advocate for raising awareness and support for improving the outcome of patients with this disease, and enhancing oncologic education worldwide.

  14. INTAS Secretary General Dr. J. Sinnaeve visiting Athena experiment.

    CERN Multimedia

    Patrice Loiez

    2002-01-01

    Photo 1: R. Landua showing ATHENA to INTAS Secretary General Dr. J. Sinnaeve. Photo 2: Visiting ATHENA are Prof. H. Bokemeyer Head of Physics at INTAS, Rolf Landus Spokesman, INTAS Secretary General Dr. J. Sinnaeve and D.O. Williams. Photo 3: Visiting ATHENA are Prof. H. Bokemeyer Head of Physics at INTAS, Rolf Landua Spokesman, INTAS Secretary General Dr. J. Sinnaeve and D.O. Williams. INTAS is an independent International Association formed by the European Community, European Union´s Member States and like minded countries acting to preserve and promote the valuable scientific potential of the NIS partner countries through East-West Scientific co-operation.

  15. Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Agathe Dubuisson

    2017-10-01

    Full Text Available Developing therapeutics that induce apoptosis in cancer cells has become an increasingly attractive approach for the past 30 years. The discovery of tumor necrosis factor (TNF superfamily members and more specifically TNF-related apoptosis-inducing ligand (TRAIL, the only cytokine of the family capable of eradicating selectively cancer cells, led to the development of numerous TRAIL derivatives targeting death receptor 4 (DR4 and death receptor 5 (DR5 for cancer therapy. With a few exceptions, preliminary attempts to use recombinant TRAIL, agonistic antibodies, or derivatives to target TRAIL agonist receptors in the clinic have been fairly disappointing. Nonetheless, a tremendous effort, worldwide, is being put into the development of novel strategic options to target TRAIL receptors. Antibodies and derivatives allow for the design of novel and efficient agonists. We summarize and discuss here the advantages and drawbacks of the soar of TRAIL therapeutics, from the first developments to the next generation of agonistic products, with a particular insight on new concepts.

  16. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Steven (U.S. Energy Secretary)

    2012-05-07

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  17. For Dr. Nancy Snyderman's Parents, Staying Close to Family Is Key

    Science.gov (United States)

    ... Current Issue Past Issues Feature: Senior Living For Dr. Nancy Snyderman's Parents, Staying Close to Family Is ... version of this page please turn Javascript on. Dr. Nancy Snyderman helped her parents, Joy and Dr. ...

  18. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / Summer 2012 Table of ... Recently, he discussed progress on high cholesterol research. Dr. Michael Lauer and his wife, Dr. Robin Avery, ...

  19. D&R Siding Co., LLC Information Sheet

    Science.gov (United States)

    D&R Siding Co., LLC (the Company) is located in Shelbyville, Tennessee. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Fayetteville, Tennessee.

  20. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Science.gov (United States)

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  1. Dr Abraham Pais, 82, physicist and science historian dies

    CERN Multimedia

    Glanz, J

    2000-01-01

    Obituary of Dr. Pais who died of heart failure in Copenhagen. He helped build the conceptual foundations of particle physics and then became a science historian, writing a critically acclaimed biography of Einstein (1 pg).

  2. Glaucoma: Eye-to-Eye with Dr. Rachel Bishop

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Glaucoma Eye-to-Eye with Dr. Rachel Bishop Past ... nerves are pale and cupped—signs of advanced glaucoma. Yet the patient wasn't aware of any ...

  3. [Career and work of Dr. Jiro Tsuboi, a hygienist].

    Science.gov (United States)

    Izumi, H

    1992-09-01

    The author recorded the career and work of Dr. Jiro Tsuboi, a hygienist and the first dean of the medical school, Kyoto Imperial University. He was born in 1862 as a son of Dr. Tameharu Tsuboi, a famous medical educator. After graduation from Tokyo University Medical School, he entered the Department of Hygienics of his mother school. In 1890, he went to Germany, and studied under Dr. Max von Pettenkofer at Ludwig Maximillians University in Munich. He also learned tuberculin therapy for tuberculosis from Dr. Robert Koch in Berlin. After he returned to Japan, he worked as a hygienist for various social needs, including serving as a committee member for mineral pollution at Ashio copper mine. In 1899, he was appointed Dean of the medical school, Kyoto Imperial University. Though he exerted himself for the school, he died at the age of 41 in 1903. His scientific contribution comprises both hygienics and bacteriology. Because of his early death, his attainment remained limited.

  4. Dr. Omalu Talks Childhood, Concussions, and CTE | Poster

    Science.gov (United States)

    Dr. Bennet Omalu, the famed forensic pathologist who discovered Chronic Traumatic Encephalopathy (CTE), recently spoke at NCI at Frederick about his upbringing as well as the trials he faced while working to educate the NFL about CTE.

  5. Portrait of Dr. Von Braun with Walt Disney, 1954.

    Science.gov (United States)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  6. Rent ubehandlet grundvand - kan vi bevare drømmen?

    DEFF Research Database (Denmark)

    Arvin, Erik

    2016-01-01

    Vi drømmer om at drikke rent ubehandlet grundvand, et sundt naturprodukt uden menneskelig indgriben. Men kan drømmen opretholdes i vores komplicerede samfund, hvor alt skal være effektivt, og hvor der ikke må være kalkpletter på glasset? Jeg har arbejdet for rent drikkevand i mere end 30 år. Det...

  7. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland is seen here (seventh from right) visiting the assembly hall for the ATLAS experiment during his recent visit to CERN. To his right is Dr. Peter Jenni (blue shirt), spokesperson for the ATLAS Collaboration. The horizontal metal cylinder behind the group is one of the eight vacuum vessels for the superconducting coils of the ATLAS barrel toroid magnet system.

  8. The research contributions of Dr. Paul Van Deusen

    Science.gov (United States)

    Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

    2015-01-01

    Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

  9. Dr-FtsA, an actin homologue in Deinococcus radiodurans differentially affects Dr-FtsZ and Ec-FtsZ functions in vitro.

    Science.gov (United States)

    Modi, Kruti; Misra, Hari S

    2014-01-01

    The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ) has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA) and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA), has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro.

  10. Dr-FtsA, an actin homologue in Deinococcus radiodurans differentially affects Dr-FtsZ and Ec-FtsZ functions in vitro.

    Directory of Open Access Journals (Sweden)

    Kruti Modi

    Full Text Available The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA, has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro.

  11. The Missing Manuscript of Dr. Jose Delgado's Radio Controlled Bulls.

    Science.gov (United States)

    Marzullo, Timothy C

    2017-01-01

    Neuroscience systems level courses teach: 1) the role of neuroanatomical structures of the brain for perception, movement, and cognition; 2) methods to manipulate and study the brain including lesions, electrophysiological recordings, microstimulation, optogenetics, and pharmacology; 3) proper interpretation of behavioral data to deduce brain circuit operation; and 4) the similarities, differences, and ethics of animal models and their relation to human physiology. These four topics come together quite dramatically in Dr. Jose Delgado's 1960s famous experiments on the neural correlates of aggression in which he stopped bulls in mid-charge by electrically stimulating basal ganglia and thalamic structures. Technical documentation on these experiments is famously difficult to find. Here I translate and discuss a Spanish language article written by Dr. Delgado in 1981 for an encyclopedia on bull fighting published in Madrid. Here Dr. Delgado appears to give the most complete explanation of his experiments on microstimulation of bovine brains. Dr. Delgado's motivations, methods, and his interpretation of the bull experiments are summarized, as well as some accompanying information from his 1970 English language book: "Physical Control of the Mind." This review of Dr. Delgado's written work on the bull experiments can provide a resource to educators and students who desire to learn more about and interpret the attention-calling experiments that Dr. Delgado did on a ranch in Andalucía over 50 years ago.

  12. [Sexuality education on the Internet : From Dr. Sommer to Dr. Google].

    Science.gov (United States)

    Döring, Nicola

    2017-07-24

    Female and male adolescents in Germany are increasingly using the Internet to find information about sexuality and sexual health. This review paper summarizes what we know about the status quo of online sexuality education in Germany.Based on a systematic literature review including 40 papers from international, peer-reviewed journals spanning 2010-2017, this paper first describes different aspects of the sexuality-related online search behavior of adolescents: its prevalence, predictors, topics and contexts. One main finding is the fact that adolescents use a computer or smartphone to type their sexuality-related questions into the search engine Google or the search engine of the video platform YouTube.Based on 54 online searches, this paper subsequently presents the kind of sexuality-related online content adolescents find if they ask "Dr. Google" for sexual advice; a collection of 1236 authentic sexuality-related questions of adolescents was used for this analysis. It turned out that online sexuality education offered by leading professional organizations like the BZgA ("Bundeszentrale für gesundheitliche Aufklärung") or pro familia was nearly invisible, while numerous other providers of online sex education consistently appeared in the top Google search results. Among them were the "Dr. Sommer" team of the youth magazine Bravo; online healthcare and advice portals; online forums; the online encyclopedia Wikipedia and, above all, sex education channels on YouTube. In this paper, the latter are presented in more detail for the first time.The third part of the paper addresses the quality of online sexual education over four main areas of quality evaluation. The presentation of the status quo ends with some recommendations both for future research and for sexuality education in practice.

  13. Volume celebrating the 60th birthday of Professor Dr. Franz Fie; Professor Dr. Franz Fiedler zum 60. Geburtstag

    Energy Technology Data Exchange (ETDEWEB)

    Beheng, K.D. [ed.

    1998-01-01

    This report was compiled in honor of Professor Dr. Franz Fiedler on the occasion of his 60th birthday on 7 January 1998. Its contributions deal with mesoscale modelling, the propagation of air pollutants, measurements of precipitation using radar, and prediction models. (orig./KW) [Deutsch] Dieser Bericht wurde aus Anlass des 60. Geburtstags von Herrn Prof. Dr. Franz Fiedler am 7. Januar 1998 zusammengestellt. Die Beitraege behandeln mesoskalige Modellierung, Ausbreitung von Luftschadstoffen, Niederschlagsmessung mit Radar und Vorhersagemodelle. (orig.)

  14. Type 1 Diabetes in the Spanish Population: additional factors to Class II HLA-DR3 and -DR4

    Directory of Open Access Journals (Sweden)

    Ibarra José M

    2005-04-01

    Full Text Available Abstract Background The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D; genome-wide scans have consistently mapped increased predisposition to this region. The highest disease risk has been associated with HLA-DR3 and HLA-DR4. In particular, the DR3-positive ancestral haplotype 18.2 was reported as highly diabetogenic. We aimed to corroborate whether this haplotype increases the susceptibility conferred by the DQ2-DR3 alleles in a Mediterranean population. We also searched for additional susceptibility factors to the classic DQ2-DR3 and DQ8-DR4. Results Genetic MHC markers were analysed in a case-control study with 302 T1D patients and 529 ethnically matched controls. DR3-TNFa1b5 carrier rate was significantly higher in DR3-positive heterozygous T1D patients than in DR3-positive heterozygous controls (p = 0.0019; odds ratio OR [95% confidence interval CI] = 2.26 [1.3–3.93]. This data was confirmed analysing the allelic frequency, which includes the information corresponding to the DR3-homozygous individuals (p = 0.001; OR = 2.09 and by using the Arlequin software to check the DR3-positive haplotypes (p = 0.004;OR = 1.93. The present results provide strong evidence of a second susceptibility region in the ancestral haplotype 18.2 in the Spanish population. Moreover, we searched for T1D susceptibility factors in addition to the MHC classical ones, within the DR2-DQ6/DR3-DQ2/DR4-DQ8 negative population. Several genetic markers in both MHC class II (DQA1*0101-DQB1*0501 [p = 0.007;OR = 2.81], DQA1*0201-DQB1*0202 [p = 0.03; OR = 2.35] and III (TNFa2b1 [p = 0.01 OR = 2.74], BAT-2*2 [p = 0.004; OR = 3.19] were found. These different alleles associated with T1D were not independent and we observed linkage disequilibrium among them leading us to describe two new risk haplotypes (DQA1*0101-DQB1*0501-TNFa2b1 and DQA1*0201-DQB1*0202- BAT-2*2. Finally, we studied a T1D susceptibility

  15. Evaluasi Integritas Sistem Struktur Jembatan Dr. Ir. Soekarno

    Directory of Open Access Journals (Sweden)

    Ady Wijayanto

    2017-08-01

    Full Text Available Dr. Ir. Soekarno Bridge is the long span bridge which to be the Manado city landmark. To calculate the Dr. Ir. Soekarno Bridge’s feasibility, integrated evaluation need to know the bridge physical condition reliability. The purpose of this analysis is for reviewing and evaluating the entire Dr. Ir. Soekarno Bridge integrity. Every structure has natural frequency characteristic, which describes the structure strength, stiffness and integrity. The vibration record data sources are dynamic loading test and accelerometer sensor records. Perception and comfortable level the bridge users evaluated by the vibration record data. Perception and comfortable level the bridge users evaluated by the vibration record data. The accelerometer sensors records on X, Y, and Z directions. The Fast Fourier Transform (FFT analysis carries out to exchange time domain to frequency domain. The frequency domain graphics filtered by ISO 2631-1 formula. Perception and comfortable level the Dr. Ir. Soekarno Bridge users are still in the comfort condition, so this bridge is proper to pass through the vehicles. Based on the Weibull Distribution, Dr. Ir. Soekarno Bridge has service life until 100 years as long as the plan service life.

  16. Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

    NARCIS (Netherlands)

    Pavet, V.; Beyrath, J.D.; Pardin, C.; Morizot, A.; Lechner, M.C.; Briand, J.P.; Wendland, M.; Maison, W.; Fournel, S.; Micheau, O.; Guichard, G.; Gronemeyer, H.

    2010-01-01

    Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) on cancer cells in vitro and in vivo. Surface

  17. Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

  18. Tun Dr. Mahathir’s Leadership Communication: The Confucian Perspective

    Directory of Open Access Journals (Sweden)

    Cheah Joyce Lynn-Sze

    2017-01-01

    Full Text Available Previous studies have provided valuable insights into the impact of culture on the concept of leadership communication. However, only a few studies that focused on exploring and understanding the values of Confucianism and its impact on the Chinese culture, especially in Malaysia. Thus, this study is among the first study to examine the leadership communication from the perspective of Confucianism towards the leadership of Dr. Mahathir from the perspective of the Chinese community in Malaysia. This study aims to assess the role of Confucian values in Dr. Mahathir’s leadership communication. This study interviewed 15 Chinese leaders. The findings reveal that three main Confucian values are relevant to Dr. Mahathir’s leadership communication. The Confucian values are Zhi (wisdom, Xin (trust and Xiao (filial piety. This study provides a new perspective on leadership communication from the context of cultural diversity in Malaysia which emphasizes on Confucian values.

  19. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  20. Dr Jacob van der Land, marine biologist extraordinary

    NARCIS (Netherlands)

    Bruggen, van A.C.

    2001-01-01

    This contribution is an attempt to sketch the life and works of Dr Jacob van der Land, curator of worms and chief marine biologist of the National Museum of Natural History, on the occasion of his official retirement. Born in 1935, Jacob van der Land read biology at Leiden University (1958-1964),

  1. 2250-IJBCS-Article-Dr Mahbou Somo Toukam

    African Journals Online (AJOL)

    hp

    154, February 2015. ISSN 1997-342X ..... Cette information est capitale. L'igname se reproduisant essentiellement par des tubercules, la ... Foundation) pour l'aide financière et en particulier son Président Dr Paul. KAMMOGNE FOKAM et son ...

  2. DR. H. BERKHOF, en VertfacAtiny, Holland Uitgevers maatschappij ...

    African Journals Online (AJOL)

    Test

    DR. H. BERKHOF, en VertfacAtiny, Holland Uitgevers maatschappij Amsterdam, 1948, 194 bis., prys 12/6. Die vererende versoek om bogenoemde boek in hierdie kolomme te bespreek het my in nie geringe verleentheid gebring nie, want om die waarheid te sê, kan ek feitlik niks as goeds daarvan getuig nie, met ander ...

  3. Page 1 DIAMAGNETISM OF COPPER. BY DR. S. RAMACHANDRA ...

    Indian Academy of Sciences (India)

    1935-08-20

    DIAMAGNETISM OF COPPER. BY DR. S. RAMACHANDRA RAO,. Aananalai University. Received August 20, 1935. 1. Introduction. IN a recent paper, the author has reviewed at Some length the present position of our knowledge regarding the magnetic properties of colloidal particles of metals. A few general conclusions ...

  4. Shepard Award Winners, Part 1: Dr. Stephen Thacker

    Centers for Disease Control (CDC) Podcasts

    2009-07-22

    This podcast highlights the accomplishments of Dr. Stephen Thacker, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 7/22/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 7/22/2009.

  5. Highlight: Dr David Butler-Jones on fighting pandemics | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 févr. 2015 ... Dr David Butler-Jones, professor in the Faculty of Medicine at the University of Manitoba and former Chief Medical Health Officer of Canada, delivered a lecture on lessons learned from the 2009 flu pandemic in Canada. He also commented on India's draft National Health Policy 2015 at the India ...

  6. Researcher Profile: An Interview With Dr. Rebecca J. Travnichek

    Directory of Open Access Journals (Sweden)

    Rebecca J. Travnichek

    2011-04-01

    Full Text Available

    Dr. Rebecca Travnichek is a Family Financial Education Specialist with University of Missouri Extension. Dr. Travnichek currently serves as the Annual Conference Program Chair. She is also very active in the Association for Financial Counseling and Planning Education, where she serves on the Board of Directors. Dr. Travnichek has participated in leadership development programs at the state and national levels. She was involved in the initial proposal development of the Financial Security for All Community of Practice with eXtension and continues to be involved through several roles. She is active in the National Extension Association of Family and Consumer Sciences at the national and state levels, serving in multiple leadership roles. For the past three years, Dr. Travnichek has also served as the Editor of the Journal of the National Extension Association of Family and Consumer Sciences. She represents the type of person who makes the Financial Therapy Association a dynamic organization linking practitioners and academicians.

  7. Shepard Award Winners, Part 3: Dr. Larissa Roux

    Centers for Disease Control (CDC) Podcasts

    2009-09-22

    This podcast highlights the accomplishments of Dr. Larissa Roux, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 9/22/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 9/22/2009.

  8. Shepard Award Winners, Part 2: Dr. Tracie Williams

    Centers for Disease Control (CDC) Podcasts

    2009-07-29

    This podcast highlights the accomplishments of Dr. Tracie Williams, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 7/29/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 7/29/2009.

  9. The Effects of Dr. Oz on Health Behaviors and Attitudes

    Science.gov (United States)

    Crouch, Elizabeth; Dickes, Lori A.; Davis, Amanda; Zarandy, Joy

    2016-01-01

    Background: Consumption of social media has quickly evolved into a primary source of health information for many consumers. This seems to be particularly true for individuals seeking to modify chronic health conditions like weight loss, obesity, and obesity-related diseases. Purpose: This study explores whether watching Dr. Oz weight loss episodes…

  10. Improving College Students English Learning with Dr. Eye Android Mid

    Science.gov (United States)

    Yang, Ju Yin; Che, Pei-Chun

    2015-01-01

    This paper investigates college students' English language learning through use of Dr. Eye Android handheld mobile Internet device (MID). Compared to related studies, students' English learning using MIDs has not been evaluated and fully understood in the field of higher education. Quantitatively, the researchers used TOEIC pretest and posttest to…

  11. Oxygen and Metastasis: A Conversation with Dr. Nick Restifo

    Science.gov (United States)

    Dr. Nick Restifo, a senior investigator in NCI’s Center for Cancer Research, discusses his recently published study finding that Oxygen, a molecule necessary for life, paradoxically aids cancer metastasis to the lung by impairing cancer-killing immune cells.

  12. Unlikely reformer: Dr Henry Calvert Barnett (1832-1897).

    Science.gov (United States)

    Martyr, Philippa

    2017-10-01

    To provide a brief biography of Western Australian colonial lunacy superintendent Dr Henry Calvert Barnett. A range of primary sources were consulted. Barnett was a complex man: a caring and forward-thinking practitioner who had a colourful and turbulent private life. Barnett's contribution to mental health service development in Western Australia was genuine and worthwhile, and should be recognised.

  13. Dr. Y. Zverev, Physiology Department, College of Medicine ...

    African Journals Online (AJOL)

    East African Medical Journal Vol. 78 No. 1 January 2001. VENTILATORY CAPACITY INDICES IN MALAWIAN CHILDREN. Y. Zverev, MD, PhD, and M. Gondwe, BSc, Physiology Department, College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, Malawi. Request for reprints to: Dr. Y. Zverev, ...

  14. You CAN Teach a Sneetch! Peace Education with Dr. Seuss.

    Science.gov (United States)

    Ghosn, Irma K.

    This lesson plan, for grades 4 to 6 and up, incorporates the Dr. Seuss story about Sneetches to teach children about sources of prejudice. The lesson also can be used to incorporate writing in the social studies. Six writing prompts are included. (EH)

  15. Another Use for Dr. Seuss: Reading for Social Skills

    Science.gov (United States)

    Wolf, Janice J.; Baker, Pamela Hudson

    2012-01-01

    Time is limited. Teachers often struggle to address the diverse needs of learners in their classrooms, especially when faced with academic and social skills concerns. Finding effective ways to teach social skills in the context of academic instruction makes sense. Books by Dr. Seuss provide a variety of high-interest stories that can be used to…

  16. Gifted Kids, Social Issues, and the Works of Dr. Seuss

    Science.gov (United States)

    Granada, Jim

    2005-01-01

    Gifted students often share a sense of justice and a concern for the welfare of mankind and the planet. This humanitarian feeling may sometimes be overlooked, given today's academic focus. The author has taken an in-depth look at the works of Theodor Geisel, popularly known as Dr. Seuss, and moved beyond his whimsical illustrations and wordplay to…

  17. Go, Class, Go: Using Dr. Seuss in Early Reading Instruction

    Science.gov (United States)

    Allman, Tamby

    2004-01-01

    As more and more reading programs make the move from the basal reading series to authentic text, teachers are asking the same question: How do I choose appropriate books for my class? Teachers of students who are deaf or hard of hearing are no exception. In this article, the author describes her use of Dr. Seuss books in early reading instruction.

  18. Obituary Dr A. W. Kloos (1880—1952)

    NARCIS (Netherlands)

    Ooststroom, van S.J.

    1952-01-01

    At the end of the previous number of “Blumea” could just be inserted the death notice of one of the honorary collaborators of the Rijksherbarium, Dr Ir A. W. Kloos, who passed away in his home at Dordrecht on June 3rd, 1952. A more detailed obituary may follow here. Abraham Willem Kloos was born at

  19. Dr. Vernon W. Hughes, 81, authority on the subatomic

    CERN Multimedia

    Lavietes, S

    2002-01-01

    "Dr. Vernon W. Hughes, a Yale physicist whose investigation of particles called muons poked holes in standard subatomic theory and provided evidence for the existence of previously undetected matter, died at Yale-New Haven Hospital last Tuesday" (1/2 page).

  20. Bullying Among Teenage Girls: An Interview with Dr. Harriet Mosatche

    Science.gov (United States)

    Prevention Researcher, 2004

    2004-01-01

    Dr. Harriet Mosatche is an advice columnist on a web site for teen girls, as well as the Senior Director of Research and Programs at the Girl Scouts of the USA. Because of these dual roles, she has a unique perspective on the bullying issue. In this interview she answers a number of questions about bullying among teenage girls, including how boys…

  1. NOGMAALS dr. G. D. SCHOLTZ SE GESKIEDENIS VAN DIE ...

    African Journals Online (AJOL)

    Test

    Statenvertaling de gezaghebbende kerk- en huisbijbel gebleven.” Dr. Scholtz beweer in sy boek op bis. 4 dat die Heidelbergse Kategis- mus reeds vóór 1559 toe die Franse konfessie vervaardig is, opgestel is deur „die Duitse Protestante”. Ek het hom op die volkome foutiewiteit van hierdie bewering gewys, maar hy hou vol ...

  2. 2166-IJBCS-Article- Dr Odette Kabena Ngandu

    African Journals Online (AJOL)

    hp

    Science and Medicine, 70(3):392–400. Kabena NO, Lukoki LF, Mpiana TP, Ngombe. KN, Fatiany RP, Baholy R, Ngbolua KN. 2014. Phytochemical Screening of some medicinal plants traditionally used by. African Women in Kinshasa city (DR. Congo) for their intimate hygiene and. Evaluation of the pH of derived recipes.

  3. Dr. Seuss's Sound Words: Playing with Phonics and Spelling.

    Science.gov (United States)

    Gardner, Traci

    Boom! Br-r-ring! Cluck! Moo!--exciting sounds are everywhere. Whether visiting online sites that play sounds or taking a "sound hike," ask your students to notice the sounds they hear, then write their own book, using sound words, based on Dr. Seuss's "Mr. Brown Can MOO! Can You?" During the three 45-minute sessions, grade K-2…

  4. Dr. Kenneth Sudduth: A giant pioneering precision agriculture

    Science.gov (United States)

    Dr. Ken Sudduth is nationally and internationally recognized for his precision agriculture research and leadership, especially in the areas of soil sensing and assessment of spatial variability for site-specific management. His many noteworthy contributions include novel techniques and methodology f...

  5. Profile Interview: Dr Lucinda Manda-Taylor | Molynuex | Malawi ...

    African Journals Online (AJOL)

    Profile Interview: Dr Lucinda Manda-Taylor. M. Molynuex. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/mmj.v28i3.1 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  6. Dynamic Star Formation in the Massive DR21 Filament

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, N.; /Saclay; Csengeri, T.; /Saclay; Bontemps, S.; /OASU, Floirac; Motte, F.; /Saclay; Simon, R.; /Cologne U.; Hennebelle, P.; /Paris Observ.; Federrath, C.; /ZAH, Heidelberg; Klessen, R.; /ZAH, Heidelberg /KIPAC, Menlo Park

    2010-08-25

    The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. By studying one of the most massive and dense star-forming regions in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing the well-known sources DR21 and DR21(OH), we attempt to obtain observational evidence to help us to discriminate between these two views. We use molecular line data from our {sup 13}CO 1 {yields} 0, CS 2 {yields} 1, and N{sub 2}H{sup +} 1 {yields} 0 survey of the Cygnus X region obtained with the FCRAO and CO, CS, HCO{sup +}, N{sub 2}H{sup +}, and H{sub 2}CO data obtained with the IRAM 30m telescope. We observe a complex velocity field and velocity dispersion in the DR21 filament in which regions of the highest column-density, i.e., dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO{sup +} and {sup 12}CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of {approx}0.6 km s{sup -1} and mass accretion rates of the order of a few 10{sup -3} M{sub {circle_dot}} yr{sup -1} for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M{sub {circle_dot}} at densities of around 10{sup 5} cm{sup -3} within 1 pc diameter) are both gravitationally contracting. The more massive of the clumps, DR21(OH), is connected to a sub-filament, apparently 'falling' onto the clump. This filament runs parallel to the magnetic field. Conclusions. All observed kinematic features in the DR21 filament (velocity field, velocity dispersion, and infall), its filamentary morphology, and the existence of (a) sub-filament(s) can be explained if the DR21 filament was formed by the convergence of flows

  7. Role of DR-70 immunoassay in suspected malignant pleural effusion

    Science.gov (United States)

    Sengupta, Amitabha; Saha, Kaushik; Jash, Debraj; Banerjee, Sourindra Nath; Biswas, Nirendra Mohan; Dey, Atin

    2013-01-01

    Context: A good proportion of patients with undiagnosed pleural effusion (PE) turn into malignancy over a period of time. Identification of positive biomarker may help in selecting the individuals who require close follow-up. Aims: The aims of this study were to evaluate the role of DR-70 immunoassay in suspected malignant PE. Settings and Design: We conducted a cross-sectional study among 89 patients of suspected malignant PE and 50 normal subjects (NS) were taken as control. Materials and Methods: Patients with exudative PE; who had pleural fluid lymphocyte count greater than 50% and adenosine deaminase less than 30 U/L were taken as cases. We had selected NSs among relatives of patients having normal blood chemistry and radiological investigations. Sensitivity and specificity of the test to differentiate malignant and non-malignant PE and also to identify PE with underlying malignancy was analyzed. Results: Mean value of DR-70 in NS was found to be 0.83 ± 0.273 mg/L without any significant difference between males (0.82 mg/L) and females (0.85 mg/L). Mean value of DR-70 in PE with underlying cancer was 5.03 ± 3.79 mg/L. Sensitivity (80%) and specificity (77.78%) of the test was maximum in PE with underlying cancer using cut-off value of 2 mg/L. Mean value DR-70 in malignant PE was 5.18 ± 3.75 mg/L and in non-malignant PE was 3.73 ± 3.74 mg/L without any statistically significant difference (P = 0.08). Conclusions: DR-70 assay has high sensitivity in detecting underlying lung cancer, but has no role in differentiating malignant PE from non-malignant PE. PMID:24339491

  8. HLA-DRB4 gene encoded HLA-DR53 specificity segregating with the HLA-DR7, -DQ9 haplotype: unusual association.

    Science.gov (United States)

    Lardy, N M; van der Horst, A R; van de Weerd, M J; de Waal, L P; Bontrop, R E

    1998-02-01

    HLA phenotyping of a leukemia patient of Caucasoid origin revealed the presence of the serological HLA-DR53 specificity. Comprehensive pedigree analysis demonstrated that the HLA-DR53 specificity segregated with the HLA-DR7, -DQ3 haplotype. High resolution PCR- SSP genotyping of the HLA class II genes revealed the presence of the HLA-DRB4*0101101 allele segregating together with the HLA-DRB1*0701, -DQA1*0201 and DQB1*03032 alleles. This finding is in contrast to known linkages in that thus far, the HLA-DR7, -DQ9 haplotype has only been described in association with the non-expressed HLA-DRB4*0103102N allele. The existence of this "novel" haplotype may be explained by a homologous recombinational event that occurred between the HLA-DR7, -DR53, -DQ2 and the HLA-DR7, -DQ9 haplotypes.

  9. HLA-DR-expressing cells and T-lymphocytes in sural nerve biopsies

    DEFF Research Database (Denmark)

    Schrøder, H D; Olsson, T; Solders, G

    1988-01-01

    was confirmed. HLA-DR expression was found in all biopsies and thus was not restricted to any particular type of neuropathy. The HLA-DR expression appeared to correlate with severity and activity of the neuropathy. HLA-DR-expressing macrophages wrapping myelinated fibers were prominent in primary demyelinating......Thirty-five sural nerve biopsies were stained immunohistochemically for HLA-DR antigen. HLA-DR was expressed on nonmyelinating Schwann cells, macrophages, vascular endothelium, and perineurium. By means of double immunofluorescence staining the identity of the HLA-DR presenting structures...

  10. Data and computing intensive applications in GENESI-DR

    Science.gov (United States)

    Cossu, Roberto; Pacini, Fabrizio; Gonçalves, Pedro; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. GENESI-DR provides a framework where data repositories can be easily integrated and users are given a single access point for discovery and access to heterogeneous data and processing resources. Processing services can be easily integrated as well so supporting the users in the analysis of the data. Coupled with high-performance and sizeable computing resources managed by Grid technologies, GENESI-DR provides indeed the necessary flexibility for building a virtual environment that gives transparent, fast, and easy access to data (even heterogeneous and dispersed among different archives), processing services, computing resources, and results. These characteristics make GENESI-DR an ideal platform for processing large amounts of heterogeneous data (e.g., satellite and in-situ data), developing services which require fast production and delivery of results, comparing approaches and fully validating algorithms. Security solutions adopted in GENESI-DR guarantee that only authorized users can access data, processing services and processing resources. GENESI-DR is designed to support the need for an effective exploitation of the large archives. Among the different applications already integrated in GENESI-DR, in this presentation we will describe some results related to

  11. Peptide binding predictions for HLA DR, DP and DQ molecules

    DEFF Research Database (Denmark)

    Wang, P.; Sidney, J.; Kim, Y.

    2010-01-01

    BACKGROUND: MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction algorithms for human MHC class II to date have targeted HLA molecules encoded in the DR locus. This reflects...... affinities for a set of 11 HLA DP and DQ alleles. We also expanded our dataset for HLA DR alleles resulting in a total of 40,000 MHC class II binding affinities covering 26 allelic variants. Utilizing this dataset, we generated prediction tools utilizing several machine learning algorithms and evaluated...... include all training data for maximum performance. 4) The recently developed NN-align prediction method significantly outperformed all other algorithms, including a naïve consensus based on all prediction methods. A new consensus method dropping the comparably weak ARB prediction method could outperform...

  12. Pulmonary and pleural pathology: Contributions of Dr. Louis "Pepper" Dehner.

    Science.gov (United States)

    Ritter, Jon H; Hill, D Ashley

    2016-11-01

    Dr. Louis Dehner is an internationally renowned surgical pathologist who has published multiple textbooks and has authored or co-authored nearly 400 original articles in the medical literature. While many think of him as a pediatric pathologist, he has contributed to the literature across virtually the entire breadth of surgical pathology, and the lung and pleura is no exception. This review will highlight Dr. Dehner׳s contributions to the pulmonary and pleural pathology literature in the areas of infectious disease, medical lung disease and transplant pathology, and a number of neoplasms of the lung and pleura, with the remainder of this manuscript dedicated to the still evolving story of the pleuropulmonary blastoma as the signature contribution of his long and distinguished career. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. N2R vs. DR Network Infrastructure Evaluation

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Roost, Lars Jessen; Toft, Per Nesager

    2007-01-01

    Recent development of Internet-based services has set higher requirements to network infrastructures in terms of more bandwidth, lower delays and more reliability. Theoretical research within the area of Structural Quality of Service (SQoS) has introduced a new type of infrastructure which meet...... these requirements: N2R infrastructures. This paper contributes to the ongoing research with a case study from North Jutland. An evaluation of three N2R infrastructures compared to a Double Ring (DR) infrastructure will provide valuable information of the practical applicability of N2R infrastructures. In order...... to study if N2R infrastructures perform better than the DR infrastructure, a distribution network was established based on geographical information system (GIS) data. Nodes were placed with respect to demographic and geographical factors. The established distribution network was investigated with respect...

  14. INTAS Secretary General Dr. J. Sinnaeve visiting Athena experiment.

    CERN Multimedia

    Patrice Loiez

    2002-01-01

    Photo 1: INTAS Secretary General Dr. J. Sinnaeve, N. Koulberg, Prof. H. Bokemeyer Head of Physics at INTAS, D.O.Williams and Rolf Landua visiting ATHENA. Photo 2: Prof. H. Bokemeyer Head of Physics at INTAS, INTAS Secretary General J. Sinnaeve and Rolf Landua visiting ATHENA. Photo 3: In the control room of ATHENA, Rolf Landua, Prof. H. Bokemeyer Head of Physics at INTAS and INTAS Secretary General Dr. J. Sinnaeve. INTAS is an independent International Association formed by the European Community, European Union´s Member States and like minded countries acting to preserve and promote the valuable scientific potential of the NIS partner countries through East-West Scientific co-operation.

  15. Optimization on scoliosis examination on Canons DR system

    DEFF Research Database (Denmark)

    Precht, Helle

    2007-01-01

    Purpose To develop my knowledge concerning the sensitivity of different scintilators when these are inter-joined with Canon’s DR receptor, specifically for exams of scoliosis. Problem Scoliosis patients are typically girls from 11 years of age and upwards that are checked repeatedly through x...... recordings of scoliosis today are carried out on CR systems even though most radiological departments have DR systems available. Theoretically speaking the two modalities are similar regarding dose and image quality. In this project consequently, the focus will be to obtain images of equal dose and quality...... are provided with the prospect for examining the following hypothesis: A Canon receptor with CsI scintilator is able to give an acceptable image quality with a lower dosage at a scoliosis recording than Canon’s receptor with a GOS scintilator. Materials and method The project relies on an empirical study...

  16. Tun Dr. Mahathir’s Leadership Communication: The Confucian Perspective

    OpenAIRE

    Cheah Joyce Lynn-Sze; Yusof Norhafezah; Ahmad Mohd Khairie

    2017-01-01

    Previous studies have provided valuable insights into the impact of culture on the concept of leadership communication. However, only a few studies that focused on exploring and understanding the values of Confucianism and its impact on the Chinese culture, especially in Malaysia. Thus, this study is among the first study to examine the leadership communication from the perspective of Confucianism towards the leadership of Dr. Mahathir from the perspective of the Chinese community in Malaysia...

  17. In memoriam dr. Anne van Wijngaarden (1925-2004)

    OpenAIRE

    Broekhuizen, S.; Laar, van, V.

    2005-01-01

    Op 4 oktober 2004 overleed Dr. Anne van Wijngaarden op 78-jarige leeftijd in zijn huis bij Millac- Carlux, Frankrijk. Hij was een van de Nederlandse oprichters van de Vereniging voor Zoogdierkunde en Zoogdierbescherming. Nadat zijn eindexamen op de middelbare school wilde Anne aanvankelijk geologie studeren, maar toen de verplichte excursies te duur bleken, werd het biologie. Nog voordat hij doctoraal-examen had gedaan, kreeg hij een baan bij de Plantenziektenkundige Dienst. Zijn eerste opdra...

  18. HYPERBILIRUBINEMIA TREATMENT OF NEONATUS IN DR. SOETOMO HOSPITAL SURABAYA

    OpenAIRE

    Hosea, Mellisa Kristanti; Etika, Risa; Lestari, Pudji

    2016-01-01

    Hyperbilirubinemia is a condition of high levels bilirubin accumulating in blood and known as jaundice, a yellow coloration of the skin, sclera and nails. Hyperbilirubinemia is a problem that often occurs in newborns. Patients with neonatal hyperbilirubinemia are treated with phototerapy and exchange transfusion. The purpose of this study was to identify the hyperbilirubinemia treatments on neonatal in Dr. Soetomo Hospital Surabaya. Medical records were used to collect information on hyperbil...

  19. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  20. DR services in Fiji: attitudes, barriers and screening practices

    Directory of Open Access Journals (Sweden)

    Bridget Kool

    2015-06-01

    Full Text Available The aim of this study was to describe the attitudes and perceptions of primary health care doctors in Fiji regarding the importance of eye care in diabetes mellitus (DM management, to explore current eye care practice, and to investigate awareness and use of relevant clinical practice guidelines. The study builds on earlier research conducted in Fiji that identified a rapid increase of late-stage DR patients presenting for treatment, at a time when surgery was the only option.

  1. Postdoctoral Fellowship for Dr. Lindholm, Underwater Physiology and Medicine

    Science.gov (United States)

    2008-05-01

    been obtained, it can be maintained with a lower intensity "maintenance training". Preliminary results in runners , in our laboratory, suggest that...in divers are supported by previous studies in runners , cyclists and rowers. The current study demonstrates that respiratory muscle fatigue may be the...G.A., Pendergast, D.R. Co-activation of the Tongue Protrudor and Retractor Muscles is not Altered in Obese Zucker Rats. American Thoraxic Annual

  2. Dr. Michael DeBakey "is a magician of the heart…"

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Then & Now Dr. Michael DeBakey "is a magician of the heart…" ... version of this page please turn Javascript on. Dr. DeBakey with NLM's David Nash and admiring students ...

  3. Practitioner Profile: An Interview with Dr. Jerry Gale, LMFT

    Directory of Open Access Journals (Sweden)

    Jerry Gale

    2012-06-01

    Full Text Available Dr. Jerry Gale is an Associate Professor and the Clinical Director of the Marriage and Family Therapy Doctoral Program at the University of Georgia. He is a Licensed Marriage and Family Therapist and an approved supervisor of the American Association of Marriage and Family Therapists. He earned a B.A. from the University of Michigan, a MEd from the University of Arizona, and a Ph.D. from Texas Tech University. Over the course of his career, Dr. Gale has authored three books and over 60 articles and book chapters. He is a co-developer of a relational financial therapy approach that combines financial counseling with family therapy and has extensive training in clinical hypnosis, couples therapy, and family therapy, as well as mindfulness meditation. He is the recipient of the American Family Therapy Academy 2006 Outstanding Research Award. In addition to his work at the University of Georgia, Dr. Gale conducts therapy at Athens Associates for Counseling and Psychotherapy.

  4. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    Science.gov (United States)

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place.

  5. Curriculum Vitae of Prof. Dr. Gürer GÜLSEVİN and Prof. Dr. Ayşe İLKER’s Impressions About Him Prof. Dr. Gürer GÜLSEVİN’in Özgeçmişi ve Prof. Dr. Ayşe İLKER’in Onun Hakkındaki İzlenimleri

    Directory of Open Access Journals (Sweden)

    Özgür AY

    2011-01-01

    Full Text Available Curriculum Vitae of Prof. Dr. Gürer GÜLSEVİN and Prof. Dr. Ayşe İLKER’s Impressions About Him Prof. Dr. Gürer GÜLSEVİN’in Özgeçmişi ve Prof. Dr. Ayşe İLKER’in Onun Hakkındaki İzlenimleri

  6. 78 FR 7438 - Prospective Grant of Exclusive License: Development of Human Monoclonal Antibodies Against DR4

    Science.gov (United States)

    2013-02-01

    ... Human Monoclonal Antibodies Against DR4 AGENCY: National Institutes of Health, Public Health Service... Monoclonal Antibodies Against DR4'' (HHS Ref. No. E-158-2010/0) to Customized Biosciences, Inc., which is... relates to the development of two human monoclonal antibodies (mAbs) that bind to death receptor 4 (``DR4...

  7. Enhancing Price Response Programs through Auto-DR: California's 2007 Implementation Experience

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila; Wikler, Greg; Chiu, Albert; Piette, Mary Ann; Kiliccote, Sila; Hennage, Dan; Thomas, Chuck

    2007-12-18

    This paper describes automated demand response (Auto-DR) activities, an innovative effort in California to ensure that DR programs produce effective and sustainable impacts. Through the application of automation and communication technologies coupled with well-designed incentives and DR programs such as Critical Peak Pricing (CPP) and Demand Bidding (DBP), Auto-DR is opening up the opportunity for many different types of buildings to effectively participate in DR programs. We present the results of Auto-DR implementation efforts by the three California investor-owned utilities for the Summer of 2007. The presentation emphasizes Pacific Gas and Electric Company's (PG&E) Auto-DR efforts, which represents the largest in the state. PG&E's goal was to recruit, install, test and operate 15 megawatts of Auto-DR system capability. We describe the unique delivery approaches, including optimizing the utility incentive structures designed to foster an Auto-DR service provider community. We also show how PG&E's Critical Peak Pricing (CPP) and Demand Bidding (DBP) options were called and executed under the automation platform. Finally, we show the results of the Auto-DR systems installed and operational during 2007, which surpassed PG&E's Auto-DR goals. Auto-DR is being implemented by a multi-disciplinary team including the California Investor Owned Utilities (IOUs), energy consultants, energy management control system vendors, the Lawrence Berkeley National Laboratory (LBNL), and the California Energy Commission (CEC).

  8. 75 FR 51869 - CAFTA-DR Consultation Request Regarding Guatemala's Apparent Failure to Effectively Enforce its...

    Science.gov (United States)

    2010-08-23

    ...] CAFTA-DR Consultation Request Regarding Guatemala's Apparent Failure to Effectively Enforce its Labor... States Free Trade Agreement (CAFTA-DR), the United States requested consultations with the Government of...-agreements/free-trade-agreements/cafta-dr-dominican-republic-central-america-fta/kirk-solis-le . USTR invites...

  9. Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5.

    Science.gov (United States)

    Ansari, A A; Freidhoff, L R; Meyers, D A; Bias, W B; Marsh, D G

    1989-05-01

    A well-characterized allergen of Lolium perenne (perennial rye grass) pollen, Lol p III, has been used as a model antigen to study the genetic control of the human immune response. Associations between HLA type and IgE or IgG antibody (Ab) responsiveness to Lol p III were studied in two groups of skin-test-positive Caucasoid adults (N = 135 and 67). We found by nonparametric and parametric analyses that immune responsiveness to Lol p III was significantly associated with HLA-DR3 and DR5. No association was found between any DQ type and immune responsiveness to Lol p III. Geometric mean IgE or IgG Ab levels to Lol p III were not different between B8+, DR3+ subjects and B8-, DR3+ subjects, showing that HLA-B8 had no influence on the association. Lol p III IgG Ab data obtained on subjects after grass antigen immunotherapy showed that 100% of DR3 subjects and 100% of DR5 subjects were Ab+. A comparison of all the available protein sequences of DRB gene products showed that the first hypervariable region of DR3 and DR5 (and DRw6), and no other region, contains the sequence Glu9-Tyr-Ser-Thr-Ser13. Our observations are consistent with the possibility that immune responsiveness to the allergen Lol p III is associated with this amino acid sequence in the first hypervariable region of the DR beta 1 polypeptide chain.

  10. Burr holes, bone flaps, and goose quills: Dr Frank Turnbull, Vancouver's first neurosurgeon.

    Science.gov (United States)

    Ye, Vincent C

    2017-01-01

    Dr Frank Turnbull was a pioneer neurosurgeon - the first neurosurgeon in Vancouver, Canada. He started his practice in 1933 after spending time during a neurosurgical 'residency' with Dr Kenneth Mackenzie, Canada's first neurosurgeon. Dr Turnbull practiced at a time when the perception of his speciality was dim, and the resources available to him were limited. However, Dr Turnbull overcame these obstacles, and two World Wars to help change the landscape of neurosurgery in the northwest Canada, and his career achievements also extend into medical politics and medical education. This paper documents the life and adventures of Dr Frank Turnbull, pioneer neurosurgeon.

  11. The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

    Science.gov (United States)

    Ramamurthy, Vidhyashankar; Yamniuk, Aaron P; Lawrence, Eric J; Yong, Wei; Schneeweis, Lumelle A; Cheng, Lin; Murdock, Melissa; Corbett, Martin J; Doyle, Michael L; Sheriff, Steven

    2015-10-01

    The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes. Consistent with the high sequence similarity between DR4 and DR5, the overall arrangement of the DR4-TRAIL complex does not differ substantially from that of the DR5-TRAIL complex. However, subtle differences are apparent. In addition, solution interaction studies were carried out that show differences in the thermodynamics of binding DR4 or DR5 with TRAIL.

  12. Dr. Stanko Sielski (1891-1958): Physician, scientist, humanist.

    Science.gov (United States)

    Tahirović, Husref

    2015-01-01

    This work presents the results of research into the life and work of Dr. Stanko Sielski, related to his professional, scientific and humanitarian work. He was born in Gračanica, Bosnia and Herzegovina (BH) in 1891, to a family of Polish origins. He attended high school in Travnik and completed his studies of medicine in Vienna in 1919. During the First World War he served on the frontlines with the Austro- Hungarian army. He began his service as a doctor in Konjic, Prozor and Glamoč, and then worked in Varcar Vakuf, Zenica, Travnik, Bihać, Banja Luka, Sarajevo and Tuzla. At that time in BH living conditions were very bad, the level of education of the people insufficient, there were many epidemics of infectious diseases, and the mortality of the population was high. Dr. Stanko Sielski made a significant contribution to treating the sick, preventing various diseases and the health education of the people. In the realm of the history of medicine in BA, he researched the life and work of doctors from previous generations, the work of medical institutions, old medical manuscripts written in Arabic, Persian and Turkish, folk beliefs about the origins and treatment of a variety of illnesses, and the role of herbal medicine and amulets in treating the sick. In addition, he undertook research in the fields of archaeology, ethnology and sociology. He published the results of his research in scholarly journals. In the Second World War he saved the lives of many Jewish doctors and their families from persecution in concentration camps, and as a result in 2014 he was posthumously declared "Righteous Among the Nations". Dr. Stanko Sielski, alongside his work as a doctor, was also involved in a variety of scientific research and publication work, which contributed to the preservation and a better understanding of the material and spiritual heritage of BH. Copyright © 2015 by Academy of Sciences and Arts of Bosnia and Herzegovina.

  13. Peptide binding predictions for HLA DR, DP and DQ molecules

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2010-11-01

    Full Text Available Abstract Background MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction algorithms for human MHC class II to date have targeted HLA molecules encoded in the DR locus. This reflects a significant gap in knowledge as HLA DP and DQ molecules are presumably equally important, and have only been studied less because they are more difficult to handle experimentally. Results In this study, we aimed to narrow this gap by providing a large scale dataset of over 17,000 HLA-peptide binding affinities for a set of 11 HLA DP and DQ alleles. We also expanded our dataset for HLA DR alleles resulting in a total of 40,000 MHC class II binding affinities covering 26 allelic variants. Utilizing this dataset, we generated prediction tools utilizing several machine learning algorithms and evaluated their performance. Conclusion We found that 1 prediction methodologies developed for HLA DR molecules perform equally well for DP or DQ molecules. 2 Prediction performances were significantly increased compared to previous reports due to the larger amounts of training data available. 3 The presence of homologous peptides between training and testing datasets should be avoided to give real-world estimates of prediction performance metrics, but the relative ranking of different predictors is largely unaffected by the presence of homologous peptides, and predictors intended for end-user applications should include all training data for maximum performance. 4 The recently developed NN-align prediction method significantly outperformed all other algorithms, including a naïve consensus based on all prediction methods. A new consensus method dropping the comparably weak ARB prediction method could outperform the NN-align method, but further research into how to best combine MHC class II binding predictions is required.

  14. Dr. Stanko Sielski (1891–1958: Physician, scientist, humanist

    Directory of Open Access Journals (Sweden)

    Husref Tahirović

    2015-11-01

    Full Text Available This work presents the results of research into the life and work of Dr. Stanko Sielski, related to his professional, scientific and humanitarian work. He was born in Gračanica, Bosnia and Herzegovina (BH in1891, to a family of Polish origins. He attended high school in Travnik and completed his studies of medicine in Vienna in 1919. During the First World War he served on the frontlines with the Austro-Hungarian army. He began his service as a doctor in Konjic, Prozor and Glamoč, and then worked in Varcar Vakuf, Zenica, Travnik, Bihać, Banja Luka, Sarajevo and Tuzla. At that time in BH living conditions were very bad, the level of education of the people insufficient, there were many epidemics of infectious diseases, and the mortality of the population was high. Dr. Stanko Sielski made a significant contribution to treating the sick, preventing various diseases and the health education of the people. In the realm of the history of medicine in BA, he researched the life and work of doctors from previous generations, the work of medical institutions, old medical manuscripts written in Arabic, Persian and Turkish, folk beliefs about the origins and treatment of a variety of illnesses, and the role of herbal medicine and amulets in treating the sick. In addition, he undertook research in the fields of archaeology, ethnology and sociology. He published the results of his research in scholarly journals. In the Second World War he saved the lives of many Jewish doctors and their families from persecution in concentration camps, and as a result in 2014 he was posthumously declared “Righteous Among the Nations”. Conclusion. Dr. Stanko Sielski, alongside his work as a doctor, was also involved in a variety of scientific research and publication work, which contributed to the preservation and a better understanding of the material and spiritual heritage of BH.

  15. Dr. Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    L. to. r.:Dr Henrik Foeth, Team Leader, CMS experiment; Dr Daniel Denegri, Physics Coordinator, CMS experiment; Prof. Tejinder Virdee, Deputy Spokesman, CMS experiment; Prof. Luciano Maiani, CERN Director-General (signing); Mr Jean-Marie Dufour, Head of the Legal Service, Mr Ghodratollah Habibpour Gharakol (back); Dr Abdolali Sharghi, Advisor to the Minister and Director General, Office of International Scientific Cooperation, Ministry of Science, Research and Technology; Dr Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran (signing); Dr Reza Mansouri, Director, International Scientific Meetings Office, Ministry of Science, Research and Technology; H. E. Dr Ali Khorram, Extraordinary and plenipotentiary Ambassador to the United Nations in Geneva and Dr Hans F. Hoffmann, CERN Director for Technology Transfer & for Scientific Computing. _

  16. Dr. Oscar Costa Mandry: a life in the tropics revealed.

    Science.gov (United States)

    Christenson, Bernard

    2007-01-01

    Dr. Oscar Costa-Mandry, "The Father of Medical Technology in Puerto Rico"; his lifetime achievements in the tropics are revealed in the context of his influential role in the School of Tropical Medicine and his clear visionary perspective for the creation of the University of Puerto Rico School of Medicine. With his unique and diverse contributions for more than 40 years in the fields of clinical laboratory medicine, public health and medical education, and as an insightful historian, he dramatically influenced and reshaped the Puerto Rican medical and social landscape for future generations to come.

  17. El Dr. Ricard Botey i la pedagogia del cant

    OpenAIRE

    Torres, Begoña; Alessandroni Betancor, Nicolás

    2016-01-01

    El Dr. Ricard Botey i Ducoing (1855-1927) s’inclinà cap a l’estudi de la veu per la seva afició al cant. Botey, junt amb altres estudiosos de la seva època anomenats “laringòlegs”, va estar profundament interessat en veure com es comportaven les cordes vocals durant la producció dels diferents sons. En 1886 publicà el seu primer llibre dedicat a la veu titulat “Higiene, desarrollo y conservación de la voz”.Aquesta primera edició no ens parla de les patologies vocals, sinó de la fisiologia de ...

  18. Dr. Ramón Ruiz Maldonado (1937-2017

    Directory of Open Access Journals (Sweden)

    María del Mar Sáez-de-Ocariz

    2017-06-01

    Full Text Available El cruzar en nuestra existencia con un ser humano como el Dr. Ramón Ruiz Maldonado, hombre culto, sensato, ingenioso y maestro en toda la extensión de la palabra, ilumina y deja huella. Cuando llega el momento de su partida, por una enfermedad prolongada que minó su cuerpo y terminó por encarcelar su mente, la sensación de vacío y nostalgia es inevitable; sólo puede verse hasta cierto punto aliviada por un profundo agradecimiento, ya que aún sin estar presente, su esencia vive en nuestro corazón.

  19. Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

    Science.gov (United States)

    1959-01-01

    This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

  20. Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Robinson and Dr. Kalousek

    Energy Technology Data Exchange (ETDEWEB)

    Bacino, C.A.; Graham, J.M. Jr. [UCLA School of Medicine, Los Angeles, CA (United States)

    1996-03-01

    This {open_quotes}Letter to the Editor{close_quotes} responds to the comments by Dr. Robinson and Dr. Kalousek regarding the implications of meiotic versus somatic chromosomal aberrations. The survival time of the patient may depend on the detection of mosicism; the discussion of the existence of full trisomy 22 remains controversial. 2 refs.

  1. Zašto postoje države-nacije, a ne svjetska država? Prilog raspravi o teoriji moderne Jacquesa Bideta

    OpenAIRE

    Katunarić, Vjeran

    2009-01-01

    U ovom se članku kritički razmatraju odgovori na pitanja “Zašto postoje države- nacije?”, odnosno “Zašto ne samo jedna država-nacija?”, koje je Jacques Bidet dao u svom djelu Opća teorije moderne. U prvom dijelu članka razmatra se Bidetova analogija između nastanka nacija-država i složenijih država poput EU-a, a napose mogućnosti stvaranja svjetske demokratske države koju je Bidet na inovativan način zamislio kao jamca jednakosti među narodima. S obzirom na normativni karakt...

  2. 2009 AMCA Memorial Lecture Honoree: Dr. Chester Lamar Meek.

    Science.gov (United States)

    Connelly, C Roxanne

    2009-09-01

    Chester Lamar Meek (1944-2000), 2009 AMCA Memorial Lecture Honoree, was husband to Sharon Kay Meek, father of Bradley Lamar and Jody Keith, and a member of the faculty of Louisiana State University for 25 years when he passed away on June 27, 2000, while conducting field research on mosquitoes in Cleveland, Mississippi. Dr. Meek was born in Monticello, Arkansas, and attended Ouachita Baptist University, University of Arkansas, and Texas A&M University, where he took his B.S., M.S., and Ph.D., respectively. He was an expert in the biology and control of rice-field mosquitoes and in forensic entomology. He served in the medical service corps of the US Army, authored or co-authored over 65 scientific publications, and was mentor to graduate students in medical and forensic entomology. Dr. Meek was a member of the Louisiana Mosquito Control Association, the Texas Mosquito Control Association, the American Mosquito Control Association, the Entomological Society of America, the American Registry of Professional Entomologists, and the Society for Vector Ecology. He received the American Mosquito Control Association's awards for Meritorious Service (1986) and the Memorial Lectureship Award (1991) and was recognized for his service by the Louisiana Mosquito Control Association with the 1989 Hathaway-Ritter Distinguished Achievement award.

  3. Show: Dr. H, the life and death of pancakes

    CERN Multimedia

    2012-01-01

    Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

  4. Spectral classification and composites of galaxies in LAMOST DR4

    Science.gov (United States)

    Wang, Li-Li; Luo, A.-Li; Shen, Shi-Yin; Hou, Wen; Kong, Xiao; Song, Yi-Han; Zhang, Jian-Nan; Wu, Hong; Cao, Zi-Huang; Hou, Yong-Hui; Wang, Yue-Fei; Zhang, Yong; Zhao, Yong-Heng

    2018-02-01

    We study the classification and composite spectra of galaxies in the fourth data release (DR4) of the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST). We select 40 182 spectra of galaxies from LAMOST DR4, which have photometric information but no spectroscopic observations in the Sloan Digital Sky Survey (SDSS). These newly observed spectra are recalibrated and classified into six classes - passive, Hα-weak, star-forming, composite, LINER and Seyfert - using the line intensity (Hβ, [O III]λ5007, Hα and [N II]λ6585). We also study the correlation between spectral class and morphological type through three parameters: concentration index, (u - r) colour and D4000n index. We calculate composite spectra of high signal-to-noise ratio (S/N) for six spectral classes and, using these composites, we pick out some features that can differentiate the classes effectively, including Hβ, Fe5015, HγA, HK and the Mg2 band. In addition, we compare our composite spectra with the SDSS ones and analyse their differences. A galaxy catalogue of 40 182 newly observed spectra (36 601 targets) and the composite spectra of the six classes are available online.

  5. Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges.

    Science.gov (United States)

    Servin, Alain L

    2014-10-01

    The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as "silent pathogens" with the capacity to emerge as "pathobionts" for the development of inflammatory bowel disease and intestinal carcinogenesis. Copyright © 2014, American Society for Microbiology. All Rights

  6. Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges

    Science.gov (United States)

    2014-01-01

    SUMMARY The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as “silent pathogens” with the capacity to emerge as “pathobionts” for the development of inflammatory bowel disease and intestinal carcinogenesis. PMID:25278576

  7. [Story of three SS dentists during World War II: Pr Hugo Blaschke, Dr Hermann Pook and Dr Willy Frank].

    Science.gov (United States)

    Riaud, Xavier

    2006-12-01

    This story of three SS dentists shows very clearly that the medical code of ethics, under a totalitarian regime, ends where ideology begins. Professor Hugo Blaschke provided dental care to the most eminent Nazi leaders, but he also was the senior SS dentist. He was in charge of dental care in the Waffen-SS, and therefore, he had responsibility for the stocks of dental gold collected from the mouths of those who died in the concentration camps, in order to make dentures for his soldiers. Dr Hermann Pook was the dentist in charge of all the other dentists practising in the concentration camps. He was responsible for gathering statistics on the dental care provided for prisoners in the camps. His instructions were very clear: "No conservation or restorative treatment. Only extractions, and with no anaesthesia!" He was also in charge of gathering the gold that was collected in the camps, for the financial department of the SS. Dr Willy Frank, an Auschwitz dentist, took part in the selection of some of the convoys for the gas chambers. His participation in the collection of gold from the mouths of the dead was also established. These three men were sentenced to prison for War Crimes and Crimes against Humanity.

  8. A "new" primed lymphocyte typing (PLT) defined DP-antigen associated with a private HLA--DR antigen

    DEFF Research Database (Denmark)

    Morling, N; Jakobsen, B K; Platz, P

    1980-01-01

    We have recently described a "new" private HLA-DR antigen, DR"LTM", which has a frequency of approximately 0.6% in Danes. Primed Lymphocyte Typing (PLT) cells directed towards DR"LTM"-associated determinants were generated in vitro by haplotype primings in two unrelated families with DR"LTM" posi...

  9. Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway.

    Directory of Open Access Journals (Sweden)

    Zhongfan Deng

    Full Text Available BACKGROUND: Hepatitis C virus (HCV is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It is believed that continuous liver cell apoptosis contributes to HCV pathogenesis. Recent studies have shown that HCV infection can sensitize host cells to TNF-related apoptosis-inducing ligand (TRAIL induced apoptosis, but the mechanism by which HCV regulates the TRAIL pathway remains unclear. METHODS AND RESULTS: Using a sub-genomic replicon and full length virus, JFH-1, we demonstrate that HCV can sensitize host cells to TRAIL-induced apoptosis by up-regulating two TRAIL receptors, death receptor 4 (DR4 and death receptor 5 (DR5. Furthermore, the HCV replicon enhanced transcription of DR5 via Sp1, and the HCV-mediated up-regulation of DR4 and DR5 required MEK1 activity. HCV infection also stimulated the activity of MEK1, and the inhibition of MEK1 activity or the knockdown of MEK1 increased the replication of HCV. CONCLUSIONS: Our studies demonstrate that HCV replication sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1 dependent pathway. These findings may help to further understand the pathogenesis of HCV infection and provide a therapeutic target.

  10. HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.

    Science.gov (United States)

    Anders, Anne-Kathrin; Call, Melissa J; Schulze, Monika-Sarah E D; Fowler, Kevin D; Schubert, David A; Seth, Nilufer P; Sundberg, Eric J; Wucherpfennig, Kai W

    2011-01-01

    The mechanisms of HLA-DM-catalyzed peptide exchange remain uncertain. Here we found that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy state of the peptide-binding groove. High-affinity peptides were protected from removal by HLA-DM through two mechanisms: peptide binding induced the dissociation of a long-lived complex of empty HLA-DR and HLA-DM, and high-affinity HLA-DR-peptide complexes bound HLA-DM only very slowly. Nonbinding covalent HLA-DR-peptide complexes were converted into efficient HLA-DM binders after truncation of an N-terminal peptide segment that emptied the P1 pocket and disrupted conserved hydrogen bonds to HLA-DR. HLA-DM thus binds only to HLA-DR conformers in which a critical part of the binding site is already vacant because of spontaneous peptide motion.

  11. Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.

    Science.gov (United States)

    Meuli, R; Pichler, W J; Gaze, H; Lentze, M J

    1995-01-01

    Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance.

  12. The extent of HLA-DR expression on HLA-DR(+) Tregs allows the identification of patients with clinically relevant borderline rejection.

    Science.gov (United States)

    Schaier, Matthias; Seissler, Nicole; Becker, Luis Eduardo; Schaefer, Sebastian Markus; Schmitt, Edgar; Meuer, Stefan; Hug, Friederike; Sommerer, Claudia; Waldherr, Rüdiger; Zeier, Martin; Steinborn, Andrea

    2013-03-01

    Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR(+) -Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent of HLA-DR expression of HLA-DR(+) -Tregs (MFI HLA-DR) were estimated in non transplanted volunteers, patients with end-stage renal failure (ESRF), healthy renal transplant patients with suspicion on rejection, due to sole histological Bord-R or sole acute renal failure (ARF), and patients with clinically relevant borderline rejection (Bord-R and ARF). Compared to patients with only Bord-R or only ARF, the suppressive activity of the total Treg cell pool was exclusively reduced in patients with clinically relevant Bord-R. In parallel, the HLA-DR MFI of the DR(+) -Treg subset was significantly decreased in these patients, due to a significantly lower proportion of DR(high+) -Tregs, which were shown to have the highest suppressive capacity within the total Treg pool. Our findings clearly demonstrate that the determination of the HLA-DR MFI of the HLA-DR(+) -Treg subset allows a highly sensitive, specific and non-invasive discrimination between patients with clinically relevant Bord-R (Bord and ARF) and patients with subclinical rejection or other causes of transplant failure. © 2013 The Authors Transplant International © 2013 European Society for Organ Transplantation. Published by Blackwell Publishing Ltd.

  13. Mapping young stellar populations toward Orion with Gaia DR1

    Science.gov (United States)

    Zari, E.; Brown, A. G. A.; de Bruijne, J.; Manara, C. F.; de Zeeuw, P. T.

    2017-12-01

    In this work we use the first data release of the Gaia mission to explore the three-dimensional arrangement and age ordering of the many stellar groups toward the Orion OB association, aiming at a new classification and characterization of the stellar population not embedded in the Orion A and B molecular clouds. We make use of the parallaxes and proper motions provided in the Tycho Gaia Astrometric Solution (TGAS) subset of the Gaia Data Release 1 (DR1) catalog and of the combination of Gaia DR1 and 2MASS photometry. In TGAS, we find evidence for the presence of a young population at a parallax ϖ 2.65 mas, which is loosely distributed around the following known clusters: 25 Ori, ɛ Ori, and σ Ori, and NGC 1980 (ι Ori) and the Orion Nebula Cluster (ONC). The low mass counterpart of this population is visible in the color magnitude diagrams constructed by combining Gaia DR1 G-band photometry and 2MASS. We study the density distribution of the young sources in the sky using a kernel density estimation (KDE). We find the same groups as in TGAS and also some other density enhancements that might be related to the recently discovered Orion X group, Orion dust ring, and λ Ori complex. The maps also suggest that the 25 Ori group presents a northern elongation. We estimated the ages of this population using a Bayesian isochronal fitting procedure assuming a unique parallax value for all the sources, and we inferred the presence of an age gradient going from 25 Ori (13-15 Myr) to the ONC (1-2 Myr). We confirmed this age ordering by repeating the Bayesian fit using the Pan-STARRS1 data. Intriguingly, the estimated ages toward the NGC 1980 cluster span a broad range of values. This can either be due to the presence of two populations coming from two different episodes of star formation or to a large spread along the line of sight of the same population. Some confusion might arise from the presence of unresolved binaries, which are not modeled in the fit, and usually mimic

  14. Musikvideo og tilskuer: Fjernsyn, ideologi og drøm

    Directory of Open Access Journals (Sweden)

    Marsha Kinder

    1987-08-01

    Full Text Available Denne artikel af Marcha Kinder er allerede en klassiker. I næsten al litteratur om musikvideoer henvises der til den - også herhjemme. Det er især hendes typologi over musikvideoerne, som der refereres til, mens artiklens percep- tionspsykologiske sammenligninger mellem musikvideoer og drømme næsten ikke har været inddraget i debatten. Marcha Kinder har arbejdet med medier i en årrække og udgav sammen med Beverle Houston "Self and Cinema A Transformalist Perspective" /(Redgrave Publishing Vompany i 1980. Artiklen "Musikvideo og tilskuer" er oversat i sin helhed fra "Music Video and the Spectator": Television, Ideology and Dream, Film Quarterly, vol. XXXVIII, no. I 1984 af Jim Høyer.

  15. In Memoriam: Prof. Dr Dragutin Djurovic (1937-2013)

    Science.gov (United States)

    2013-12-01

    Prof. dr Dragutin Djurovic was born in Guca, Serbia, on December 20, 1937. He completed his primary and secondary education in Guca and Cacak. In the period 1956-1958, he studied at the General Military Academy in Belgrade. He enrolled at the Faculty of Sciences and Mathematics - Astronomy Group in 1958 and graduated in 1963. After graduation he went to study visits to Paris (1966) and Bruxelles (1972 and 1975). He obtained his MSc degree in 1970 from the University of Belgrade with a thesis entitled "Application of different types of telescopes for astronomical determination of time". His supervisor for the master thesis was Prof. Zaharije Brkic. Dragutin Djurovic defended his PhD thesis "Contribution to determination of Earth-rotation variations and polar motion" at the University of Belgrade in 1974. Most of the thesis-related research was done in Bruxelles during 1972 under the supervision of Prof. Paul Melchior.

  16. Mr. Jan Hendrik Bannier and Dr. Gosta Funke

    CERN Multimedia

    CERN PhotoLab

    1966-01-01

    (on the left) : Mr. Jan Hendrik Bannier has been President of the Council at CERN for the years 1964, 1965 and 1966 and was President of the Finance Committee from 1958 to 1960. He is now a member of the Site Evaluation Panel for the 300 GeV accelerator project. In the Netherlands, he is Director of ZWO (Organization for the Advancement of Pure Research) and also Vice-President of the National Commission for UNESCO. (on the right) : Dr. Gosta Funke, who has represented his country at CERN Council sessions since the beginning of the Organization, was elected President of the Council for 1967 at its Thirty-third Session, in December. In Sweden, he has been Secretary-General of the State Council for Atomic Research since 1959. He is also President of the Council of ESO (European Southern Observatory), an organization building in Chili.

  17. Dr. Euler's fabulous formula Cures many mathematical ills

    CERN Document Server

    Nahin, Paul J

    2006-01-01

    I used to think math was no fun'Cause I couldn't see how it was doneNow Euler's my heroFor I now see why zeroEquals e[pi] i+1--Paul Nahin, electrical engineer In the mid-eighteenth century, Swiss-born mathematician Leonhard Euler developed a formula so innovative and complex that it continues to inspire research, discussion, and even the occasional limerick. Dr. Euler's Fabulous Formula shares the fascinating story of this groundbreaking formula--long regarded as the gold standard for mathematical beauty--and shows why it still lies at the heart of complex number theory. This book is the seque

  18. DR og musikken - en blues til 90´erne

    Directory of Open Access Journals (Sweden)

    Lars Ole Bonde

    1991-08-01

    Full Text Available Musikken i radioen er et af de mange underbelyste temaer inden for me- dieforskningen i Danmark. Forfatteren til den følgende artikel har gennem nogle år arbejdet som musik-medarbejder i Danmarks Radio - med base i Østjyllands Radio. I artiklen fokuserer han på produktionsaspektet. Hvilke funktionssammenhænge indgår musikken i inden for den kanalombrudte Danmarks Radio - både som selvstændig programform og som "akkompag- nement" til andet programstof? Dernæst følger man musikproduktionens mange former og får her afdækket både ex- og implicitte rammer for musik- politikken i institutionen. Herudfra rejses spørgsmålet om musikkens rolle i DR som aktiverende eller registrerende i forhold til det musikliv, som findes uden for institutionen.

  19. GPS/DR Error Estimation for Autonomous Vehicle Localization

    Directory of Open Access Journals (Sweden)

    Byung-Hyun Lee

    2015-08-01

    Full Text Available Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level.

  20. Prof dr FJ van Zyl as mens, kerkman en godsdiensfilosoof

    Directory of Open Access Journals (Sweden)

    P. J. van der Merwe

    1989-01-01

    Full Text Available Prof Dr FJ van Zyl as person, church personality and philosopher of religion Professor Francois Jacobus van Zyl (1913-05-06 - served as Head of the Department of Science of Religion and Missiology, Faculty of Theology (Section: Nederduitsch Hervormde Kerk, University of Pretoria, during the period 1960-1978. This article (written by a former student of his and present Head of the same Department contains a short biography, a discussion of his views on Theology, Science of Religion and Philosophy of Religion, and a bibliography. He is portrayed as a theologian with Barthian convictions, while been influenced by Emil Brunner and to a lesser extent by Hendrik Kraemer also. His primary audience was the Nederduitsch Hervormde Kerk and his theological activities (especially in the period 1960-1983 must be seen in relation to his influential role in same church.

  1. A 10,000 YEAR OLD EXPLOSION IN DR21

    Energy Technology Data Exchange (ETDEWEB)

    Zapata, Luis A.; Perez-Goytia, Nadia; Rodriguez, Luis F.; Loinard, Laurent [Centro de Radioastronomia y Astrofisica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacan (Mexico); Schmid-Burgk, Johannes [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany); Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Cruz-Gonzalez, Irene [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Ap. 70-264, 04510 DF (Mexico)

    2013-03-10

    Sensitive high angular resolution ({approx}2'') CO(2-1) line observations made with the Submillimeter Array of the flow emanating from the high-mass star-forming region DR21 located in the Cygnus X molecular cloud are presented. These new interferometric observations indicate that this well known enigmatic outflow appears to have been produced by an explosive event that took place about 10,000 years ago, and that might be related to the disintegration of a massive stellar system such as the one that occurred in Orion Becklin-Neugebauer/Kleinman-Low 500 years ago, but about 20 times more energetic. This result therefore argues in favor of the idea that the disintegration of young stellar systems perhaps is a frequent phenomenon present during the formation of massive stars. However, many more theoretical and observational studies are still needed to confirm our hypothesis.

  2. [Interculturality in the medical practice of Dr. Albert Schweitzer].

    Science.gov (United States)

    Campos-Navarro, Roberto; Ruiz-Llanos, Adriana

    2004-01-01

    Albert Schweitzer (1875-1965) was a young and promising German who at age 29 decided to undertake the profession of Medical Doctor at the University of Strassburg after finishing a career in musical studies in Paris (1899) and obtaining in Berlin a doctoral degree in Philosophy and Theology. Surprisingly, Albert Schweitzer, despite his comfortable life in Europe, decided in 1913 to practice his medical career in a remote and small Equatorial African country. He devoted nearly 50 years of his life caring for the Black population at Lamaberene, where he built a hospital. In this paper, we attempt to develop some theoretical aspects related with interculturality in the medical practice of Dr. Albert Schweitzer. We begin by considering certain sociocultural variables in hospitals that give care to patients with cultural characteristics that are substantially different from those of the health care personnel who organize, administer, and execute medical functions.

  3. GPS/DR Error Estimation for Autonomous Vehicle Localization.

    Science.gov (United States)

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-08-21

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level.

  4. Dr Robert Proust: a gynaecologist's contribution to world literature.

    Science.gov (United States)

    de Costa, Caroline

    2013-09-01

    Dr Robert Proust, though overshadowed in history by his more famous brother, the novelist Marcel Proust, was an eminent and innovative French surgeon who achieved recognition largely as a gynaecologist, but also was an accomplished urologist and general surgeon. He was the author of a textbook, The surgery of the female genital tract, that was very successful in his lifetime and ran to six editions. He was always very supportive of his brother's writing, and after Marcel's premature death Robert edited and arranged for publication of the final three volumes of his novel À la recherche du temps perdu, which has been called the greatest novel of the twentieth century. Copyright © 2013. Published by Elsevier Ireland Ltd.

  5. DR 21(OH): A HIGHLY FRAGMENTED, MAGNETIZED, TURBULENT DENSE CORE

    Energy Technology Data Exchange (ETDEWEB)

    Girart, J. M.; Frau, P. [Institut de Ciencies de l' Espai, (CSIC-IEEC), Campus UAB, Facultat de Ciencies, C5p 2, E-08193 Bellaterra, Catalonia (Spain); Zhang, Q. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Koch, P. M.; Tang, Y.-W.; Lai, S.-P.; Ho, P. T. P. [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 10617, Taiwan (China); Qiu, K., E-mail: girart@ice.cat [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China)

    2013-07-20

    We present high angular resolution observations of the massive star-forming core DR21(OH) at 880 {mu}m using the Submillimeter Array (SMA). The dense core exhibits an overall velocity gradient in a Keplerian-like pattern, which breaks at the center of the core where SMA 6 and SMA 7 are located. The dust polarization shows a complex magnetic field, compatible with a toroidal configuration. This is in contrast with the large, parsec-scale filament that surrounds the core, where there is a smooth magnetic field. The total magnetic field strengths in the filament and in the core are 0.9 and 2.1 mG, respectively. We found evidence of magnetic field diffusion at the core scales, far beyond the expected value for ambipolar diffusion. It is possible that the diffusion arises from fast magnetic reconnection in the presence of turbulence. The dynamics of the DR 21(OH) core appear to be controlled energetically in equal parts by the magnetic field, magnetohydrodynamic turbulence, and the angular momentum. The effect of the angular momentum (this is a fast rotating core) is probably causing the observed toroidal field configuration. Yet, gravitation overwhelms all the forces, making this a clear supercritical core with a mass-to-flux ratio of {approx_equal} 6 times the critical value. However, simulations show that this is not enough for the high level of fragmentation observed at 1000 AU scales. Thus, rotation and outflow feedback are probably the main causes of the observed fragmentation.

  6. Susan G. Komen for the Cure

    Science.gov (United States)

    ... de sus senos:Consejos útiles para mujeres El Cancer de Mama y el Medio Ambiente: Preguntas y Respuestas Guía de herramientas de educación sobre el cancer de seno para comunidades hispanas/Latinas About Us ...

  7. Entretien avec Susan Holtz | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au seuil du prochain millénaire, le développement planétaire durable pose des défis complexes et d'envergure. Partout dans le monde, on cherche à relever ces défis en intégrant les politiques environnementales, sociales et économiques.

  8. Dr. William Gates, Dean, Graduate School of Business and Public Policy, Biography

    OpenAIRE

    2012-01-01

    Biography of Dr. William Gates, Dean, Graduate School of Business and Public Policy, Naval Postgraduate School, Monterey, CA. Dr. William (Bill) Gates, Associate Professor and Associate Dean of Research, was appointed the Dean of the Graduate School of Business and Public Policy (GSBPP) effective February 1, 2009. A graduate of Yale University (Ph.D.) and UC San Diego, Dr. Gates has been a professor of economics in GSBPP since 1988. Prior to joining NPS he was an economist at the Jet...

  9. GENESI-DR Portal: a scientific gateway to distributed repositories

    Science.gov (United States)

    Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of

  10. Expression and mutational analysis of DinB-like protein DR0053 in Deinococcus radiodurans.

    Science.gov (United States)

    Appukuttan, Deepti; Seo, Ho Seong; Jeong, Sunwook; Im, Sunghun; Joe, Minho; Song, Dusup; Choi, Jungjoon; Lim, Sangyong

    2015-01-01

    In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation) and mitomycin C (MMC) exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din) gene dr0053 may be regulated at the transcriptional and post-translational levels.

  11. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans.

    Science.gov (United States)

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-06-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses.

  12. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans

    Directory of Open Access Journals (Sweden)

    Jianhui Cheng

    2015-06-01

    Full Text Available Deinococcus radiodurans (DR is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses.

  13. Expression and mutational analysis of DinB-like protein DR0053 in Deinococcus radiodurans.

    Directory of Open Access Journals (Sweden)

    Deepti Appukuttan

    Full Text Available In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation and mitomycin C (MMC exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din gene dr0053 may be regulated at the transcriptional and post-translational levels.

  14. Safety evaluation for packaging for 1720-DR sodium-filled tank

    Energy Technology Data Exchange (ETDEWEB)

    Mercado, M.S.

    1996-03-09

    Preparations are under way to sell the sodium stored in the 1720-DR tank in the 1720-DR building. This will require that the tank, as well as the 1720-DR facility, be moved to the 300 Area, so that the sodium may be melted and transferred into a railroad tanker car. Because the sodium is a hazardous material and is being shipped in a nonspecification packaging, a safety evaluation for packaging (SEP) is required. This SEP approves the sodium-filled tank for a single shipment from the 105-DR area to the 300 Area.

  15. Overexpression of HLA-DR is associated with prognosis of glioma patients.

    Science.gov (United States)

    Diao, Jinfu; Xia, Tianbao; Zhao, Hongwei; Liu, Jialin; Li, Bin; Zhang, Zhiwen

    2015-01-01

    Since the poor prognosis of glioma, our study was aimed to find out the role of HLA-DR in the prognosis of glioma patients that may contribute to the timely post-operative treatment on the glioma patients. 60 glioma patients were enrolled in the prospective cohort study. Western blotting was used to detect the content of HLA-DR. Kaplan-Meier curve was adopted to evaluate the effects of HLA-DR on the survival time of glioma patients. Cox regression analysis was used to evaluate the roles of clinical features and HLA-DR in the pathogenesis of glioma. The expression level of HLA-DR was higher in tumor tissue, compared with normal tissues (PDR were correlated with the factors of pathological degree, Enneking staging and KPS score. The survival rate of patients with high content of HLA-DR was lower than those of patients with low content of HLA-DR. Cox regression analysis indicated that Enneking staging and HLA-DR were all associated with the prognosis of glioma (HR=14.43, 95% CI=1.05-199.16; HR=21.39, 95% CI=2.07-220.76). HLA-DR may serve as a biomarker for the prognosis of glioma patients.

  16. Jürgen Dröge : Eestimaa lilled panevad südame põksuma / Jürgen Dröge ; interv. Annika Poldre

    Index Scriptorium Estoniae

    Dröge, Jürgen, 1941-

    2005-01-01

    Ametist lahkuv Saksamaa Liitvabariigi suursaadik Eestis Jürgen Dröge oma karjäärist välisteenistuses, Eestist saadud muljetest, Saksamaa ja Venemaa suhetest, Balti riikide arengust Euroopa Liidus

  17. Donor selection in pediatric kidney transplantation using DR and DQ eplet mismatching: A new histocompatibility paradigm.

    Science.gov (United States)

    Bryan, Christopher F; Chadha, Vimal; Warady, Bradley A

    2016-11-01

    It is now appreciated that more HLA-DR mismatching at the time of the first renal transplant is associated with higher degrees of sensitization, lower rates and longer times to retransplantation, and worse graft outcomes in children who are subsequently retransplanted. As such, our pediatric renal transplant program preferentially uses 0 or 1 HLA-DR-mismatched kidneys and reserves 2 DR-mismatched kidneys for recipients with an eminent need for a kidney. Based on a new HLA class II epitope matching strategy that is designed to minimize dnDSA production to DR and DQ antigens, we evaluated the prevalence of DR and DQ eplet mismatching for dd offers made to our pediatric wait-listed candidates. Each candidate/dd pair were HLA-DR (β1 and β3 and/or β5) and DQ (α1 and β1) allele typed by rSSO and were then evaluated for eplet mismatches by the HLAMatchmaker program. We evaluated 78 offers made to 16 children on our UNOS waiting list from 27 consecutive dd from 4/14/14 to 3/23/15. The data show that 40% (8/20) of the 1 DR-mismatched dd offers and 64% (37/58) of the 2 DR-mismatched offers were in the high-risk category for both DR and DQ dnDSA development. Whereas only 15% (3/20) of the 1 DR-mismatched offers and 5% (3/58) of the 2 DR-mismatched offers were in the low-risk category for both DR and DQ dnDSA development, 55% and 33% of the 1 DR- and 2 DR-mismatched offers, respectively, had a favorable DQ eplet mismatch threshold. In summary, HLA class II eplet mismatching is common in potential pediatric transplant recipient/donor pairs. Additional study will be necessary to validate the DR and DQ eplet threshold levels in children and to determine whether eplet mismatching strategies in donor selection result in improved transplant outcome and decreased dnDSA production. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Evaluasi Fungsi Insinerator Dalam Memusnahkan Limbah B3 Di Rumah Sakit NI Dr.Ramelan Surabaya

    Directory of Open Access Journals (Sweden)

    Jahn Leonard Saragih

    2013-09-01

    Full Text Available Pengelolaan limbah padat B3 di Rumah Sakit TNI Angkatan Laut Dr. Ramelan sangat penting diperhatikan karena dapat berdampak buruk apabila tidak dikelola dengan baik. Oleh sebab itu diperlukan adanya penelitian untuk mengidentifikasi jumlah timbulan dan penanganan limbah padat B3, mengevaluasi manajemen, penyimpanan sementara serta mengevaluasi proses insinerasi. Evaluasi fungsi incinerator di Rumah Sakit TNI Angkatan Laut Dr. Ramelan dilakukan dengan meneliti jumlah timbulan limbah B3, kapasitas pembakaran insinerator, suhu pembakaran insinerator, densitas limbah dan abu pembakaran, dan tes TCLP residu pembakaran incinerator Rumah Sakit TNI Angkatan Laut Dr. Ramelan. Dalam penelitian ini, Rumkital Dr. Ramelan memusnahkan limbah dengan incinerator. Limbah B3 yang dihasilkan Rumkital Dr. Ramelan dimusnakan dengan satu incinerator dengan type KAMINE TYPE BDR-INC 10. Limbah yang dimusnahkan di Rumkital Dr. Ramelan berasal dari Rumkital Dr. Ramelan dan Lantamal Perak. Setelah dilakukan penelitian langsung selama 14 hari berturut-turut, didapatkan bahwa rata-rata timbulan limbah B3 di Rumkital Dr. Ramelan adalah 89.98 Kg/hari dan dengan densitas rata-rata limbah ialah 166,67 kg/m3. Tinggat removal dari pembakaran limbah dengan incinerator di Rumah Sakit TNI Angkatan Laut Dr. Ramelan ialah 82,63%. Pengelolaan abu sisa incinerator Rumkital Dr. Ramelan belum sesuai dengan peraturan yang berlaku dan dari penelitian yang dilakukan yaitu pengujian kandungan abu incinerator, solidifikasi abu incinerator dengan perbandingan semen:abu adalah 1:3 dan uji TCLP, didapatkan bahwa limbah abu sisa insinerator Rumah Sakit TNI Angkatan Laut Dr. Ramelan Surabaya, dapat ditimbun pada landfill kategori I sesuai dengan Keputusan Kepala Bapedal No.4 Tahun 1995.

  19. [WHO AFFECTS THE PATIENT, DR. GOOGLE OR THE DOCTOR?].

    Science.gov (United States)

    Mishali, Moshe; Avrech, Tova

    2015-09-01

    In the last decade the World Wide Web has become one of the prime sources for medical data searches. The abundance of information and emphasis on consumer communication, which are the main characteristics of the new generation of the web named "Web 2.0", enable users to engage and educate others by sharing and collaborating knowledge. It also enables them to receive medical information based on the experience of other patients, while the duration of the traditional physician's visit has shortened. However, using Web 2.0 for health collaboration has drawbacks as well: When alternative ways of "knowing" replace objective medical facts, there is danger of misinformation and truth "flattening". This article examines the distribution of medical misinformation online: Its characteristics, the nature of the messages presented online and the means that might help protect users and patients from it. The authors hold positions in the Israeli Dairy Board (IDB): Dr. Averch manages the health field on the IDB, and the findings in this article are based on research that she is leading as part of this position, and Dr. Mishali is a trained psychologist, and acts as a strategic consultant for IDB in the field of coping with the opposition to milk and its products. In this article it is initially shown how the characteristics of information distribution in general help spreading medical misinformation online: The decline of doctors' authority as sole providers of medical information, disillusionment and suspicion towards science and the notion of expertise, and the emergence of new ways to evaluate information, based on community ties. The nature of this pseudo-medical information will then be discussed, including the range of the phenomenon and the probability of users to be affected by it. Furthermore, we will raise specific tactics in which anti-establishment messages are portrayed; examples will be given of the use of emotion evoking content in the anti-establishment messages

  20. The influence of Dr. Hsiang-Tung Chang on neuroscience in Union of Soviet Socialist Republics.

    Science.gov (United States)

    Jiang, Chun

    2012-10-25

    As one of the founders of Chinese neuroscience, Dr. Hsiang-Tung Chang's return to China has a profound impact on neuroscience in China. As many people expected, this action also may have influenced the development of neuroscience in other Eastern countries. Therefore, Dr. Chang's move may have changed the history of neuroscience in a greater area than China.

  1. The Honorable Dr Adolfo Urso, Vice Minister for Foreign Trade, "Viceministro delle Attivita' Produttive, Italia"

    CERN Document Server

    Patrice Loïez

    2002-01-01

    Photo 01: The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy, visiting SM18 with (from l to r): Dr Roberto Saban, Technical Coordination and Planning, LHC machine; Prof. Luciano Maiani, CERN Director-General; Dr Mario Gerbino, Director General of the Ministry and Prof. Lucio Rossi, LHC Main Magnet and Superconductors (MMS) Group Leader. Photo 02: Prof. Luciano Maiani, CERN Director-General and The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy, in front of one of the LHC superconducting magnet in SM18. Photo 03 :In front of one of the LHC superconducting magnets - from left to right Dr Roberto Saban, Technical Coordination and Planning, LHC machine; The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy and Prof. Luciano Maiani, CERN Director-General. Photo 04: In the SM18 hall (from l. to r.) Prof. Luciano Maiani, CERN Director-General, The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy and Dr Mario Ge...

  2. Dr. James McGee shows three astronauts how to handle non-poisonous snake

    Science.gov (United States)

    1967-01-01

    Dr. James W. McGee (right), Medical Operations Office, Manned Spacecraft Center, shows three astronauts how to handle a non-poisonous snake during desert survival training in Washington state. Left to right, are Astronauts Thomas K. Mattingly, Alfred M. Worden, and John L. Swigert Jr.; and Dr. McGee. The astronauts are dressed in faked Arab clothing.

  3. Annotated Bibliography of Dr Salmani Nodoushan's Research on Education and Language Teaching

    Science.gov (United States)

    Etemadfar Kashani, Abbas Ali

    2016-01-01

    This is an annotated bibliography of the research conducted on education and language teaching and assessment by Dr. Mohammad Ali Salmani Nodoushan in the past 25 years. This bibliography is a precise picture of the current state of education and language teaching and assessment in Iran. Dr. Salmani Nodoushan is the most distinguished Iranian…

  4. Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

    Science.gov (United States)

    Pavet, Valeria; Beyrath, Julien; Pardin, Christophe; Morizot, Alexandre; Lechner, Marie-Charlotte; Briand, Jean-Paul; Wendland, Miriam; Maison, Wolfgang; Fournel, Sylvie; Micheau, Olivier; Guichard, Gilles; Gronemeyer, Hinrich

    2010-02-01

    Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) on cancer cells in vitro and in vivo. Surface plasmon resonance revealed up to several thousand-fold increased affinities of TRAIL(mim/DR5)-receptor complexes on generation of divalent and trivalent molecules, the latter of which was achieved with a conformationally restricted adamantane core. Notably, only multivalent molecules triggered a substantial DR5-dependent apoptotic response in vitro. In tumor models derived from human embryonic kidney cells or primary foreskin fibroblasts, TRAIL(mim/DR5) peptides exerted a cancer cell-selective action that could synergize with resveratrol in a manner independent of p53. In a xenograft model of human colon cancer, a divalent TRAIL(mim/DR5) peptide inhibited tumor growth. Our results offer a proof-of-principle for the development of synthetic small molecules to trigger the TRAIL apoptosis pathway for cancer therapy.

  5. PROCESS VALUE ANALYSIS PADA INSTALASI LABORATORIUM PATOLOGI KLINIK RSUP DR. WAHIDIN SUDIROHUSODO MAKASSAR

    OpenAIRE

    FILDZAH, AUNI PRATIWI

    2017-01-01

    2017 ABSTRAK Process Value Analysis Pada Instalasi Laboratorium Patologi Klinik RSUP Dr. Wahidin Sudirohusodo Makassar RSUP Dr. Wahidin Sudirohusodo Makassar Clinical Pathology Laboratory Process Value Analysis Fildzah Auni Pratiwi Sri Sundari Muallimin Rumah sakit sebagai suatu organisasi nonprofit yang memberikan pelayanan kesehatan kepada masyarakat perlu untuk melakukan perbaikan secara berkelanjutan pad...

  6. Reader-Response to Dr. Seuss: Middle School Students and Social Issues.

    Science.gov (United States)

    Cobb, Susan M.

    A study investigated to what extent average middle school students were able to perceive the social issues embedded in literature by Dr. Seuss. Seventy-four seventh-grade students responded to five Dr. Seuss stories in free-writing exercises, response worksheets, and question worksheets. Results showed that the majority of students (approximately…

  7. A balanced approach: Dr. Biswell's solution to fire issues in urban interface and wildland ecosystems

    Science.gov (United States)

    Carol Rice

    1995-01-01

    Dr. Biswell's approach to fire management balanced fire prevention, suppression, and fuel management. Dr. Biswell maintained that with increased support for fire prevention and fuel management, several profound changes would be anticipated, including a decrease in the number of wildfires, as well as a decrease in requirements for suppression. Interested persons...

  8. Data of evolutionary structure change: 1DR8A-1ISOA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DR8A-1ISOA 1DR8 1ISO A A ------------------------MKVAVLPGDGIGPEV...70 1ISO A 1ISO...CA 388 PHE CA 401 PRO CA 322 GLU CA 240 1ISO... A 1ISOA TQVYGQDV...VAL CA 456 VAL CA 489 SER CA 527 1ISO

  9. Data of evolutionary structure change: 1DR8B-3ICDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DR8B-3ICDA 1DR8 3ICD B A ------------------------MKVAVLPGDGIGPEV...LA CA 264 3ICD ...A 3ICDA AVEKAYKGERKIS HHHH...e>PHE CA 404 PRO CA 327 GLU CA 244 3ICD... A 3ICDA TQVYGQDVWLPA

  10. Kako lahko posameznik izraža svoje aktivno državljanstvo?

    Directory of Open Access Journals (Sweden)

    Natalija Žalec

    1999-12-01

    Full Text Available Organizacija družbe v državi ima lahko različne oblike -od monokratskih do republikanskih, od enorežimskih do demokratičnih. Po drugi strani pa so države, gledano z zgodovinskega vidika, nastajale zelo različno - zaradi zgodovinskega razvoja, geografskih razmer, zagotavljanja interesov različnih sil, ki so se pojavljale in se usklajevale med seboj v različnih obdobjih. Začetna ugotovitev torej je, da država nedvomno ni pojav, ki bi imel eno samo podobo trajnejše ali nespremenljive kakovosti. Država se spreminja pod vplivom razvoja družbe v njej sami in tudi zaradi razvoja družbe zunaj nje - na primer v drugih državah. Državo nedvomno določa formalno pravo, ki določa profil državljana in hkrati velja za vse državljane.

  11. Three moving groups detected in the LAMOST DR1 archive

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, J. K.; Zhao, G.; Chen, Y. Q.; Tan, K. F. [Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Oswalt, T. D. [Embry-Riddle Aeronautical University, 600 S. Clyde Morris Blvd., Daytona Beach, FL 32114 (United States); Zhang, Y., E-mail: zjk@nao.cas.cn, E-mail: oswaltt1@erau.edu [Nanjing Institute of Astronomical Optics and Technology, National Astronomical Observatories, Chinese Academy of Sciences, Nanjing 210042 (China)

    2014-05-20

    We analyze the kinematics of thick disk and halo stars observed by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. We have constructed a sample of 7993 F, G, and K nearby main-sequence stars (d < 2 kpc) with estimates of position (x, y, z) and space velocity (U, V, W) based on color and proper motion from the Sloan Digital Sky Survey DR9 catalog. Three 'phase-space overdensities' are identified in (V, √(U{sup 2}+2V{sup 2})) with significance levels of σ > 3. Two of them (the Hyades-Pleiades stream and the Arcturus-AF06 stream) have been identified previously. We also find evidence for a new stream (centered at V ∼ –180 km s{sup –1}) in the halo. The formation mechanisms of these three streams are analyzed. Our results support the hypothesis that the Arcturus-AF06 stream and the new stream originated from the debris of a disrupted satellite, while the Hyades-Pleiades stream has a dynamical origin.

  12. Dr. Monaco Examines Lab-on a-Chip

    Science.gov (United States)

    2003-01-01

    Dr. Lisa Monaco, Marshall Space Flight Center's (MSFC's) project scientist for the Lab-on-a-Chip Applications Development (LOCAD) program, examines a lab on a chip. The small dots are actually ports where fluids and chemicals can be mixed or samples can be collected for testing. Tiny channels, only clearly visible under a microscope, form pathways between the ports. Many chemical and biological processes, previously conducted on large pieces of laboratory equipment, can now be performed on these small glass or plastic plates. Monaco and other researchers at MSFC in Huntsville, Alabama, are customizing the chips to be used for many space applications, such as monitoring microbes inside spacecraft and detecting life on other planets. The portable, handheld Lab-on-a Chip Application Development Portable Test System (LOCAD-PTS) made its debut flight aboard Discovery during the STS-116 mission launched December 9, 2006. The system allowed crew members to monitor their environment for problematic contaminants such as yeast, mold, and even E.coli, and salmonella. Once LOCAD-PTS reached the International Space Station (ISS), the Marshall team continued to manage the experiment, monitoring the study from a console in the Payload Operations Center at MSFC. The results of these studies will help NASA researchers refine the technology for future Moon and Mars missions. (NASA/MSFC/D.Stoffer)

  13. Carbon Stars Identified from LAMOST DR4 Using Machine Learning

    Science.gov (United States)

    Li, Yin-Bi; Luo, A.-Li; Du, Chang-De; Zuo, Fang; Wang, Meng-Xin; Zhao, Gang; Jiang, Bi-Wei; Zhang, Hua-Wei; Liu, Chao; Qin, Li; Wang, Rui; Du, Bing; Guo, Yan-Xin; Wang, Bo; Han, Zhan-Wen; Xiang, Mao-Sheng; Huang, Yang; Chen, Bing-Qiu; Chen, Jian-Jun; Kong, Xiao; Hou, Wen; Song, Yi-Han; Wang, You-Fen; Wu, Ke-Fei; Zhang, Jian-Nan; Zhang, Yong; Wang, Yue-Fei; Cao, Zi-Huang; Hou, Yong-Hui; Zhao, Yong-Heng

    2018-02-01

    In this work, we present a catalog of 2651 carbon stars from the fourth Data Release (DR4) of the Large Sky Area Multi-Object Fiber Spectroscopy Telescope (LAMOST). Using an efficient machine-learning algorithm, we find these stars from more than 7 million spectra. As a by-product, 17 carbon-enhanced metal-poor turnoff star candidates are also reported in this paper, and they are preliminarily identified by their atmospheric parameters. Except for 176 stars that could not be given spectral types, we classify the other 2475 carbon stars into five subtypes: 864 C-H, 226 C-R, 400 C-J, 266 C-N, and 719 barium stars based on a series of spectral features. Furthermore, we divide the C-J stars into three subtypes, C-J(H), C-J(R), and C-J(N), and about 90% of them are cool N-type stars as expected from previous literature. Besides spectroscopic classification, we also match these carbon stars to multiple broadband photometries. Using ultraviolet photometry data, we find that 25 carbon stars have FUV detections and that they are likely to be in binary systems with compact white dwarf companions.

  14. Brightest galaxies as halo centre tracers in SDSS DR7

    Science.gov (United States)

    Lange, Johannes U.; van den Bosch, Frank C.; Hearin, Andrew; Campbell, Duncan; Zentner, Andrew R.; Villarreal, Antonio; Mao, Yao-Yuan

    2018-01-01

    Determining the positions of halo centres in large-scale structure surveys is crucial for many cosmological studies. A common assumption is that halo centres correspond to the location of their brightest member galaxies. In this paper, we study the dynamics of brightest galaxies with respect to other halo members in the Sloan Digital Sky Survey DR7. Specifically, we look at the line-of-sight velocity and spatial offsets between brightest galaxies and their neighbours. We compare those to detailed mock catalogues, constructed from high-resolution, dark-matter-only N-body simulations, in which it is assumed that satellite galaxies trace dark matter subhaloes. This allows us to place constraints on the fraction fBNC of haloes in which the brightest galaxy is not the central. Compared to previous studies, we explicitly take into account the unrelaxed state of the host haloes, velocity offsets of halo cores and correlations between fBNC and the satellite occupation. We find that fBNC strongly decreases with the luminosity of the brightest galaxy and increases with the mass of the host halo. Overall, in the halo mass range 1013-1014.5 h- 1M⊙ we find fBNC ∼ 30 per cent, in good agreement with a previous study by Skibba et al. We discuss the implications of these findings for studies inferring the galaxy-halo connection from satellite kinematics, models of the conditional luminosity function and galaxy formation in general.

  15. Cholera, canals, and contagion: Rediscovering Dr. Beck's report.

    Science.gov (United States)

    Tuite, Ashleigh R; Chan, Christina H; Fisman, David N

    2011-08-01

    Cholera first appeared in North America (in Montreal and Quebec) in 1832 and spread rapidly across the eastern half of the continent. The dispatch of American disease control experts to Lower Canada in anticipation of cholera's spread implies that medical professionals expected spread, possibly from contagion, even though the notion that cholera was contagious was disparaged in medical writings of the time, and would be until John Snow's landmark work in London in the 1850s. Snow's insights derived largely from his observations on spatial and temporal patterns of cholera cases. We discuss a document from the 1832 epidemic, the report of Dr. Lewis Beck to New York's Governor Throop, which anticipates Snow in presenting geospatial data that imply cholera's contagiousness. Beck shows that the movements of immigrants along the newly completed New York state canal system resulted in sequential cholera outbreaks along the canal's path. Although aware of the degree to which this suggested contagion, Beck argues strenuously against the contagiousness of cholera. We explore the social context of early nineteenth-century medicine that probably led Beck to disbelieve his own observations, and to favor a medical model inconsistent with his data. Themes that emerge from our inquiry include belief in disease as a physical manifestation of defective morality, stigmatization of the poor and immigrant groups, and reluctance to overturn prevailing medical models that themselves reflected the economic position of medical practitioners. We show that these themes continue to serve as obstacles to innovation in medical and public health practice today.

  16. HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal

    Science.gov (United States)

    Anders, Anne-Kathrin; Call, Melissa J.; Schulze, Monika-Sarah E. D.; Fowler, Kevin D.; Schubert, David A.; Seth, Nilufer P.; Sundberg, Eric J.; Wucherpfennig, Kai W.

    2010-01-01

    The mechanisms of HLA-DM catalyzed peptide exchange remain uncertain. We found that all stages of the interaction of DM with HLA-DR were dependent on the occupancy state of the peptide binding groove. High-affinity peptides were protected from removal by DM through two mechanisms: peptide binding induced dissociation of a long-lived complex of empty DR and DM, and high-affinity DR-peptide complexes bound DM only very slowly. Non-binding covalent DR-peptide complexes were converted to efficient DM binders upon truncation of an N-terminal peptide segment that emptied the P1 pocket and disrupted conserved hydrogen bonds to MHC. DM thus only binds to DR conformers in which a critical part of the binding site is vacant, due to spontaneous peptide motion. PMID:21131964

  17. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  18. An increased HLA DR2 frequency is seen in aplastic anemia patients.

    Science.gov (United States)

    Nimer, S D; Ireland, P; Meshkinpour, A; Frane, M

    1994-08-01

    The underlying etiology of aplastic anemia is unknown in the majority of patients, although medications, chemical exposure, or viral infections can be implicated in some. Genetic susceptibility to a variety of diseases has been shown and it has recently been suggested that aplastic anemia is more common in individuals who are HLA DR2+ than in the general population. To examine this question, we retrospectively analyzed the results of HLA-DR typing in 75 aplastic anemia patients who received antithymocyte globulin (ATG) therapy or an HLA-matched sibling bone marrow transplant at UCLA between 1978 and 1989. Thirty-one patients were DR2+, a 1.9-fold higher incidence than the expected number of 16.6 patients (P < .0005). Of the 37 patients who received ATG, 33 were evaluable for a response; 14 patients had either a complete (4 patients) or partial (10 patients) response, for an overall response rate of 42.4%. Of the 14 DR2+ patients who received ATG, 7 responded, for a 50% response rate, which is not significantly higher than the response rate for the DR2- patients (7 of 19 [36.8%]; P = .50). The median survival of patients who are DR2+ was slightly, but not significantly, longer than that of the DR2- patients in the ATG group (P = .19). Although the incidence of HLA DR2 was clearly increased in these patients with aplastic anemia, response rates to ATG were not significantly different in the DR2+ and DR2- patients.

  19. CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia.

    Science.gov (United States)

    Xing, Limin; Liu, Chunyan; Fu, Rong; Wang, Huaquan; Wang, Jun; Liu, Xiao; Feng, Le; Li, Lijuan; Liu, Hui; Wang, Honglei; Zhang, Tian; Shao, Zonghong

    2014-09-01

    The aim of the present study was to investigate the number and function of CD8+HLA-DR+ cells, which are considered to be activated cytotoxic T lymphocytes (CTLs), in peripheral blood to further examine the pathogenesis of severe aplastic anemia (SAA). Thirty-eight patients with SAA were included in the present study. Patients were screened for paroxysmal nocturnal hemoglobinuria by flow cytometry using anti-CD55 and anti-CD59 antibodies. The number of CD8+HLA-DR+ T cells was measured by three-color flow cytometry using anti-CD8-peridinin chlorophyll, anti-CD3-fluorescein isothiocyanate (FITC) and anti-HLA-DR-FITC antibodies. The expression of perforin, granzyme B, tumor necrosis factor-β (TNF-β) and FasL in CD8+HLA-DR+ T cells was detected by flow cytometry with the appropriate monoclonal antibodies. Total RNA was prepared from purified CD8+HLA-DR+ cells of healthy controls and SAA patients, and then polymerase chain reaction (PCR) was performed. Apoptosis of CD8+HLA-DR+ cells was detected by flow cytometry following staining with Annexin V. The proportion of CD8+HLA-DR+ T cells was analyzed by flow cytometry in peripheral blood and was identified to be significantly higher in untreated SAA than in remission patients and in the controls. The expression of perforin, granzyme B, TNF-β and FasL in CD8+HLA-DR+ T cells was analyzed by flow cytometry and PCR, which revealed increased expression in the untreated SAA group compared with that in the control group. Furthermore, the apoptosis of CD3- bone marrow cells from normal individuals was enhanced following co-culture with CD8+HLA-DR+ T cells from untreated SAA patients. In conclusion, the present study demonstrated that CD8+HLA-DR+ T cells may contribute to bone marrow failure in SAA.

  20. Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome.

    Science.gov (United States)

    Tolva, Johanna; Paakkanen, Riitta; Jarva, Hanna; Pussinen, Pirkko; Havulinna, Aki S; Salomaa, Veikko; Sinisalo, Juha; Lokki, Marja-Liisa

    2017-09-21

    Elevated soluble HLA-DR (sHLA-DR) serum levels have been reported in HLA class II-associated inflammatory disorders. We have previously shown that the HLA class II allele HLA-DRB1*01 may predispose to acute coronary syndromes (ACS). To our knowledge, sHLA-DR serum levels have not been studied in ACS. sHLA-DR serum levels were measured in 477 ACS patients as cases and 475 area- and sex-matched controls by sandwich enzyme-linked immunosorbent assay. Binary logistic regression and ordinal logistic regression analyses adjusted for clinical parameters were conducted to evaluate the associations of sHLA-DR levels. ACS patients had lower sHLA-DR serum levels compared to controls (OR = 0.837; 95% CI = 0.704-0.994; p = 0.043). After adjustment for smoking status, this association was no longer significant. This was explained by the notion that current smoking was inversely associated with sHLA-DR levels both in cases (OR = 0.592; 95% CI = 0.553-0.908; p = 0.016) and in controls (OR = 0.356; 95% CI = 0.226-0.563; p = 0.000010). A similar effect was not seen with other cardiovascular risk factors. The results indicate, for the first time, that lower sHLA-DR levels are associated with smoking, but not with ACS. This is an important finding because previous studies of sHLA-DR have not accounted for the possible associations between smoking and sHLA-DR levels. Further studies are required to confirm these novel results and explore the mechanisms behind the observed associations. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules.

    Science.gov (United States)

    Denzin, L K; Hammond, C; Cresswell, P

    1996-12-01

    Major histocompatibility complex (MHC) class II-positive cell lines which lack HLA-DM expression accumulate class II molecules associated with residual invariant (I) chain fragments (class II-associated invariant chain peptides [CLIP]). In vitro, HLA-DM catalyzes CLIP dissociation from class II-CLIP complexes, promoting binding of antigenic peptides. Here the physical interaction of HLA-DM with HLA-DR molecules was investigated. HLA-DM complexes with class II molecules were detectable transiently in cells, peaking at the time when the class II molecules entered the MHC class II compartment. HLA-DR alpha beta dimers newly released from I chain, and those associated with I chain fragments, were found to associate with HLA-DM in vivo. Mature, peptide-loaded DR molecules also associated at a low level. These same species, but not DR-I chain complexes, were also shown to bind to purified HLA-DM molecules in vitro. HLA-DM interaction was quantitatively superior with DR molecules isolated in association with CLIP. DM-DR complexes generated by incubating HLA-DM with purified DR alpha beta CLIP contained virtually no associated CLIP, suggesting that this superior interaction reflects a prolonged HLA-DM association with empty class II dimers after CLIP dissociation. Incubation of peptide-free alpha beta dimers in the presence of HLA-DM was found to prolong their ability to bind subsequently added antigenic peptides. Stabilization of empty class II molecules may be an important property of HLA-DM in facilitating antigen processing.

  2. The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes.

    Science.gov (United States)

    Baschal, E E; Aly, T A; Jasinski, J M; Steck, A K; Johnson, K N; Noble, J A; Erlich, H A; Eisenbarth, G S

    2009-02-01

    The goal of this study was to develop and implement methodology that would aid in the analysis of extended high-density single nucleotide polymorphism (SNP) major histocompatibility complex (MHC) haplotypes combined with human leucocyte antigen (HLA) alleles in relation to type 1 diabetes risk. High-density SNP genotype data (2918 SNPs) across the MHC from the Type 1 Diabetes Genetics Consortium (1240 families), in addition to HLA data, were processed into haplotypes using PedCheck and Merlin, and extended DR3 haplotypes were analysed. With this large dense set of SNPs, the conservation of DR3-B8-A1 (8.1) haplotypes spanned the MHC (>/=99% SNP identity). Forty-seven individuals homozygous for the 8.1 haplotype also shared the same homozygous genotype at four 'sentinel' SNPs (rs2157678 'T', rs3130380 'A', rs3094628 'C' and rs3130352 'T'). Conservation extended from HLA-DQB1 to the telomeric end of the SNP panels (3.4 Mb total). In addition, we found that the 8.1 haplotype is associated with lower risk than other DR3 haplotypes by both haplotypic and genotypic analyses [haplotype: p = 0.009, odds ratio (OR) = 0.65; genotype: p = 6.3 x 10(-5), OR = 0.27]. The 8.1 haplotype (from genotypic analyses) is associated with lower risk than the high-risk DR3-B18-A30 haplotype (p = 0.01, OR = 0.23), but the DR3-B18-A30 haplotype did not differ from other non-8.1 DR3 haplotypes relative to diabetes association. The 8.1 haplotype demonstrates extreme conservation (>3.4 Mb) and is associated with significantly lower risk for type 1 diabetes than other DR3 haplotypes.

  3. Signature in the microcosm with Professor Bas S.C.J.J. Kortmann, Rector Magnificus Dr Anton A.J.M. Franken, Vice President Radboud University Nijmegen Kingdom of the Netherlands and Dr. Jos Engelen, Chief Scientific Officer of CERN.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Signature in the microcosm with Professor Bas S.C.J.J. Kortmann, Rector Magnificus Dr Anton A.J.M. Franken, Vice President Radboud University Nijmegen Kingdom of the Netherlands and Dr. Jos Engelen, Chief Scientific Officer of CERN.

  4. Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis.

    Science.gov (United States)

    Niu, Zhili; Zhang, Pingan; Tong, Yongqing

    2015-01-01

    Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE) susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to systematically summarize and explore whether specific HLA-DRB1 alleles confer susceptibility or resistance to SLE and lupus nephritis. This review was guided by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach. A comprehensive search was made for articles from PubMed, Medline, Elsevier Science, Springer Link and Cochrane Library database. A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0. At the allelic level, HLA-DR4, DR11 and DR14 were identified as protective factors for SLE (0.79 [0.69,0.91], P  0.05). DR4 and 11 (OR, 0.55 [0.39, 0.79], P lupus nephritis. DR3 and DR15 (OR, 2.00 [1.49, 2.70], P lupus nephritis. HLA-DR8, DR9 and DR14 (OR, 1.47 [0.9, 2.33], P > 0.05; 0.90 [0.64, 1.27], P > 0.05; 0.61 [0.36, 1.03], P > 0.05, respectively) were not statistically significant between the lupus nephritis and control groups. The HLA-DR4, DR11, DR14 alleles might be protective factors for SLE and HLA-DR3, DR9, DR15 were potent risk factors. In addition, HLA-DR4 and DR11 alleles might be protective factors for lupus nephritis and DR3 and DR15 suggest a risk role. These results proved that HLA-DR3, DR15, DR4 and DR11 might be identified as predictors for lupus nephritis and SLE. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  5. [Dr James Lovelock and story about GAIA hypothesis].

    Science.gov (United States)

    Gajić, Vladimir

    2011-01-01

    Gaia is the Anglo-Saxon term for the Hellenic term Gea or Ge, which means Earth. The GAIA hypothesis was launched almost 40 years ago by the famous chemist James Lovelock, who was engaged by the National Aeronautics and Space Administration (NASA) to create a sensitive instrument for searching forms of extraterrestrial life on other planets. Then he published the book The ages of GAIA, which perturbed the world's scientific public of those days. Lovelock struck upon this idea in the late sixties of the past century, during the space race with Russians, when he was hired hy the National Aeronautics and Space Administration to conduct a series of experiments to find and explore life forms on the planet Mars. Experiments executed by the American module Viking failed to trace any life form, as Lovelock had predicted. He called it a dead equilibrium. Then he turned to Earth, whose perspective is totally different from its first neighbors. Venus and Mars, and is far from a dead equilibrium. DAISYWORLD: In this hypothesis. Lovelock represents Earth as one living, giant super organism, composed of all living creatures and its material environnent. In that super organisnm, the level of oxygen, weather conditions, ocean salinity and so on are under constant influence of physical, chemical and biological processes, which provide the existence for such life forms on Earth. Dr James Lovelock represents a pioneer of climatology, and his hypothesis gives a unique insight into the correlation of dynamic processes on our planet, no matter whether they are of physical or biological nature.

  6. [Dr Lorenzo Dojmi di Delupis- the "Leopard" from Vis].

    Science.gov (United States)

    Jamnicki Dojmi, Mirko

    2011-01-01

    Dr Lorenzo Dojmi di Delupis (1845-1927) was a descendant of a respectful aristocratic family from Vis. His father was Peter Dojmi di Delupis (1809-1886), an attorney, a moderate pro-Italian autonomist, and a mayor of Vis, and his mother was Margherita Siminati. As soon as he graduated from the Medical University of Graz in 1870, he joined the Ottoman army as a physician for a two-year journey in which he reached as far as Baghdad and Basra. He left notes about this dramatic, juvenile adventure in his diaries. In 1878, he married a Viennese girl Maria Neidl and brought her home to Vis, where he got a position of municipal doctor. He had an extraordinary diagnosing acuity, great sympathy for patients, and was always willing to help, which is why he was adored by all the people of Vis, whether they agreed with his autonomist ideas or not, and soon became "the father of Vis". He was the first to warn of leprosy in Dalmatia, when he diagnosed two cases in Vis. Beside medicine and politics, he was also a passionate botanist. He was the first to seed palms in Vis and to grow a palm nursery with his agronomist son Peter Dojmi, for the whole of Dalmatia. He also tried breeding ostriches and growing Mexican coffee. He funded a small meteorological station in Vis, and planned to open a health resort with professor Schröter from Vienna. Even though Lorenzo Dojmi di Delupis held the great Italian culture very dear, his vocation as a physician and humanist inclination never let him burn with the fervour of a political extremist. Thanks to his psychophysical stability, he overcame numerous difficulties in life and retained faith in people. All these traits evoke Prince Salina, the leading character of the renowned novel Il gattopardo (The Leopard) by Giuseppe Tomasi di Lampedusa, which is why the author has so entitled this article "The Gattopardo of Vis".

  7. Then & Now: Research Pays Off for All Americans / Dr. Virginia Apgar: Keeping Score at Baby's First Cry | NIH ...

    Science.gov (United States)

    ... Research Pays Off for All Americans Dr. Virginia Apgar: Keeping Score at Baby's First Cry Past Issues / ... Every baby born in America benefits from Dr. Apgar's pioneering work to identify quickly which newborns need ...

  8. Dr Fijiwara, Head of the Internet research Institute, Mr Ogino, Executive and Head of Ubiquitous Lab of IRI, Japan

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Japanese delegation from the Internet Research Institute visiting the ATLAS assembly hall in building 180 with Dr. Akira Yamaguchi, KEK laboratory, ATLAS experiment (first from left) and Dr. Masaya Ishino, University of Tokyo, ATLAS experiment (third from left).

  9. Myofiber HLA-DR expression is a distinctive biomarker for antisynthetase-associated myopathy.

    Science.gov (United States)

    Aouizerate, Jessie; De Antonio, Marie; Bassez, Guillaume; Gherardi, Romain K; Berenbaum, Francis; Guillevin, Loïc; Berezne, Alice; Valeyre, Dominique; Maisonobe, Thierry; Dubourg, Odile; Cosnes, Anne; Benveniste, Olivier; Authier, François Jérôme

    2014-10-23

    To assess the value of major histocompatibility complex (MHC) class II antigen (HLA-DR) expression to distinguish anti-synthetase myopathy (ASM) from dermatomyositis (DM). Muscle biopsies from patients with ASM (n = 33), DM without anti-synthetase antibodies (ASAb) (n = 17), and normal muscle biopsy (n = 10) were first reviewed. ASAb included anti-Jo1 (26/33), anti-PL12 (4/33), anti-PL7 (2/33), and anti-EJ (1/33). Immunohistochemistry was performed for MHC-I/HLA-ABC, MHC-II/HLA-DR, membrane attack complex (C5b-9), neural cell adhesion molecule (NCAM)/CD56 expression, and inflammatory cell subsets. Twenty-four ASM and 12 DM patients from another center were added for HLA-DR evaluation. Ubiquitous myofiber HLA-ABC expression was equally observed in ASM and DM (93.9% vs 100%, NS). In contrast, myofiber HLA-DR expression was found in 27/33 (81.8%) ASM (anti-Jo1: 23/26, 88.5%; others: 5/7, 71.4%) vs 4/17 (23.5%) DM patients (p DR was perifascicular in ASM, a pattern not observed in DM. In addition, C5b-9 deposition was observed on sarcolemma of non-necrotic perifascicular fibers in ASM, while, in DM, C5b-9was mainly detected in endomysial capillaries. CD8 cells were more abundant in ASM than in DM (p DR expression correlated positively with the CD8+ cells infiltrates. Strictly similar observations were made in the confirmatory study. ASM is characterized by strong myofiber MHC-II/HLA-DR expression with a unique perifascicular pattern, not described so far. HLA-DR detection must be included for routine myopathological diagnosis of inflammatory/dysimmune myopathies. HLA-DR expression in ASM may indicate a specific immune mechanism, possibly involving IFNγ.

  10. VizieR Online Data Catalog: KiDS-ESO-DR3 multi-band source catalog (de Jong+, 2017)

    Science.gov (United States)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Erben, T.; Hildebrandt, H.; Kuijken, K.; Sikkema, G.; Brescia, M.; Bilicki, M.; Napolitano, N. R.; Amaro, V.; Begeman, K. G.; Boxhoorn, D. R.; Buddelmeijer, H.; Cavuoti, S.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; La Barbera, F.; Longo, G.; McFarland, J. P.; Nakajima, R.; Paolillo, M.; Puddu, E.; Radovich, M.; Rifatto, A.; Tortora, C; Valentijn, E. A.; Vellucci, C.; Vriend, W-J.; Amon, A.; Blake, C.; Choi, A.; Fenech, Conti I.; Herbonnet, R.; Heymans, C.; Hoekstra, H.; Klaes, D.; Merten, J.; Miller, L.; Schneider, P.; Viola, M.

    2017-04-01

    KiDS-ESO-DR3 contains a multi-band source catalogue encompassing all publicly released tiles, a total of 440 survey tiles including the coadded images, weight maps, masks and source lists of 292 survey tiles of KiDS-ESO-DR3, adding to the 148 tiles released previously (50 in KiDS-ESO-DR1 and 98 in KiDS-ESO-DR2). (1 data file).

  11. 76 FR 62494 - Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim...

    Science.gov (United States)

    2011-10-07

    ... Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim `Ali al-Badri...-Samarra'I, Also Known as Dr. Ibrahim Awwad Ibrahim al-Samarra'I, Also Known as Abu Du'a, Also Known as Dr..., also known as Dr. Ibrahim `Awwad Ibrahim `Ali al-Badri, also known as Ibrahim `Awad Ibrahim al-Badri al...

  12. Dr. John Frederick May and the identification of John Wilkes Booth's body.

    Science.gov (United States)

    Spiegel, A D

    1998-10-01

    Shortly after President Abraham Lincoln's assassin was killed on April 26, 1865, a formal inquest was held to positively identify the body. Dr. John Frederick May, a leading surgeon in the District of Columbia, was summoned to examine the remains. Two years earlier, Dr. May had removed a fibroid tumor from the back of the assassin's neck and an identifiable large ugly scar resulted when the wound inadvertently opened and healed by granulation. Based upon the recognition of the scar made by his scalpel, Dr. May made a positive identification.

  13. Feasibility of using Littoral Combat Ship (LCS) for Humanitarian Assistance / Disaster Relief (HA/DR) operations

    OpenAIRE

    Ng, Fuquan

    2012-01-01

    This thesis addresses the feasibility of using Littoral Combat Ship (LCS) in conducting Humanitarian Assistance / Disaster Relief (HA/DR) operations and analyzes the suite of LCS mission packages in conducting HA/DR operations through a Systems Engineering study. The current preference for HA/DR operations is on using big decks, e.g., Amphibious Ship and Aircraft Carriers to maximize the lift capability of supplies, such as medical supplies, food, and water. The trade-off of using big decks i...

  14. Maternal HLA-DR Homozygosity is not Associated with an Increased Risk of Fetal Loss

    Directory of Open Access Journals (Sweden)

    David C. Kilpatrick

    1994-01-01

    Full Text Available An attractive but controversial hypothesis holds that HLA similarit\\ between mother and offspring predisposes to early fetal loss, Against this background, Hoff et al. ( 1992 have reported a significant association between maternal HLA-DR homozygosity and fetal loss in a cohort of multigravid American women, To re-examine this finding independently, a similar investigation was carried out on a comparable group of British subjects. The HLA-DR data of 75 multigravid women were analysed: the proportion of women who had experienced fetal loss did not differ between HLA-DR homozygous and heterozygous subjects.

  15. VizieR Online Data Catalog: KiDS-ESO-DR3 multi-band source catalog (de Jong+, 2017)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Erben, T.; Hildebrandt, H.; Kuijken, K.; Sikkema, G.; Brescia, M.; Bilicki, M.; Napolitano, N. R.; Amaro, V.; Begeman, K. G.; Boxhoorn, D. R.; Buddelmeijer, H.; Cavuoti, S.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; La Barbera, F.; Longo, G.; McFarland, J. P.; Nakajima, R.; Paolillo, M.; Puddu, E.; Radovich, M.; Rifatto, A.; Tortora, C; Valentijn, E. A.; Vellucci, C.; Vriend, W-J.; Amon, A.; Blake, C.; Choi, A.; Fenech Conti, I.; Herbonnet, R.; Heymans, C.; Hoekstra, H.; Klaes, D.; Merten, J.; Miller, L.; Schneider, P.; Viola, M.

    2017-01-01

    KiDS-ESO-DR3 contains a multi-band source catalogue encompassing all publicly released tiles, a total of 440 survey tiles including the coadded images, weight maps, masks and source lists of 292 survey tiles of KiDS-ESO-DR3, adding to the 148 tiles released previously (50 in KiDS-ESO-DR1 and 98 in

  16. Designing for Data with Ask Dr. Discovery: Design Approaches for Facilitating Museum Evaluation with Real-Time Data Mining

    Science.gov (United States)

    Nelson, Brian C.; Bowman, Cassie; Bowman, Judd

    2017-01-01

    Ask Dr. Discovery is an NSF-funded study addressing the need for ongoing, large-scale museum evaluation while investigating new ways to encourage museum visitors to engage deeply with museum content. To realize these aims, we are developing and implementing a mobile app with two parts: (1) a front-end virtual scientist called Dr. Discovery (Dr. D)…

  17. Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lundegaard, Claus; Blicher, Thomas

    2008-01-01

    is derived from a large compilation of quantitative HLA-DR binding events covering 14 of the more than 500 known HLA-DR alleles. Taking both peptide and HLA sequence information into account, the method can generalize and predict peptide binding also for HLA-DR molecules where experimental data is absent...

  18. Gaia DR1 documentation Chapter 7: Catalogue consolidation and validation

    Science.gov (United States)

    Arenou, F.; Babusiaux, C.; Blanco-Cuaresma, S.; Borrachero, R.; Cantat-Gaudin, T.; Fabricius, C.; Findeisen, K.; Helmi, A.; Hutton, A.; Luri, X.; Marrese, P.; Marinoni, S.; Marrese, P.; Robin, A.; Sordo, R.; Soria, S.; Turon, C.; Utrilla Molina, E.; Vallenari, A.

    2017-12-01

    The Gaia Catalogue does not only produce a wealth of data, it also represents a complex processing before a Catalogue can be issued. The main data processing is being handled by three DPAC Coordination Units, CU3 for the astrometric data, CU5 for the photometric data and CU6 for the spectroscopic data. Then three Coordination Units analyse the processed data, CU4 for optical or binary stars, solar system objects and extended objects, CU7 for variable stars, and CU8 for classification. Finally, CU9 takes care of the intermediate and final publication of the Gaia data. For Gaia DR1, the situation has been simplified in the sense that CU4, CU6 and CU8 did not contribute to the first Catalogue. At the last step, several data fields may have been computed by several Coordination Units (e.g., parallaxes computed by CU3, then again by CU4 with a fit of an astrometric + binary model if the star happens to have a significant binary motion; or a mean magnitude computed by CU5 may be superseded by another estimation from CU7 if the stars happens to be a periodic variable; etc.), in several Data Processing Centres, so an (a) homogeneous, (b) convenient, (c) consistent Catalogue has to be built. First, to a so-called CompleteSource is attached astrometric and photometric information, then possible variability information is integrated, producing an homogeneous Catalogue. Second, sources that do not meet some minimum astrometric or photometric quality are filtered out. The filters applied are described in Section 4 of Gaia Collaboration et al. (2016a). Third, while flat files are kept for further operations, the data is integrated inside the Gaia Archive Core System (GACS) database; crossmatch with external catalogues is also performed, providing the convenient access to the data. Fourth, the consistency of the Catalogue is obtained through a dedicated validation of its content. Sources that do not pass the validation criteria are then filtered out. This chapter describes these

  19. Q&A with Dr. Koob about Treatment for Alcohol Problems

    Science.gov (United States)

    ... A with Dr. Koob about Treatment for Alcohol Problems Past Issues / Winter 2015 Table of Contents George ... FDA-approved medications that can help curb alcohol problems? It may be because medications are still a ...

  20. Profiles in Performing Arts Medicine Courage--A Tribute to Dr. Alice Brandfonbrener.

    Science.gov (United States)

    Manchester, Ralph A

    2015-09-01

    I was honored and privileged to join Dr. Robert Sataloff in delivering a tribute to Dr. Alice Brandfonbrener at the 2015 Symposium on the Medical Problems of Performing Artists in Snowmass, Colorado. As virtually everyone who reads this journal knows, Dr. Brandfonbrener organized the first symposium (then focused on the medical problems of musicians), was the founding editor of Medical Problems of Performing Artists, and was the first president of the Performing Arts Medicine Association. She died in 2014, just prior to last year's symposium. This year, after Dr. Sataloff presented a very engaging overview of Alice's career and impressive accomplishments, I gave a short address that was based on some of the editorials Alice wrote in this journal during her 20 year tenure as editor. I have chosen a few examples of how the courage that she demonstrated in launching an international medical conference, a peer-reviewed medical journal, and a professional association continued to present itself in her writing.

  1. Voordrag vir die toekenning van die graad Doctor Educationis, honoris causa, aan prof. dr. Jan Waterink.

    Directory of Open Access Journals (Sweden)

    J. C. Coetzee

    1955-03-01

    Full Text Available Die Raad en die Senaat het op hul vergaderinge in November 1954 besluit om aan prof. dr. Jan Waterink, gebore 20 Oktober 1890, die graad Doctor Educationis honoris causa toe te ken.

  2. IgD serum levels are influenced by HLA-DR phenotype.

    Science.gov (United States)

    Lio, D; Candore, G; Colucci, A T; Modica, M A; Caruso, C

    1992-01-01

    In the present paper we have evaluated IgD serum levels of 84 randomly selected HLA-typed healthy Sicilians. The values were analysed according to age, sex and HLA-DR phenotypes. No correlation between age and IgD serum levels was found in our population since all subjects were in a narrow age range. Furthermore, no significant association was found between IgD serum levels and gender of studied subjects. The evaluation of IgD serum levels according to HLA-DR phenotypes revealed that HLA-DR1 positive subjects displayed significantly higher values. These results are in agreement with previous reports showing that HLA phenotypes may be involved in the control of serum immunoglobulin levels. Furthermore, present data strengthen our suggestion that HLA-DR1 phenotype is related to the 'high responder' immunological profile.

  3. Transcript of speech by Dr. Ira Gabrielson to the Constitutional Convention, December 14, 1955

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Transcript of speech by Dr. Ira Gabrielson, president of Wildlife Management Institute, to Alaska Constitutional Convention, December 14, 1955.

  4. Making a Difference: The 1982 Humane Education Teacher of the Year-- Dr. Arlene Brooks.

    Science.gov (United States)

    Savesky, Kathy

    1982-01-01

    Profiles Dr. Arlene Brooks (1982 Humane Education Teacher of the Year) and four other teachers named as finalists. Discusses accomplishments, responsibilities, and humane education experiences/activities of these five individuals. (JN)

  5. DIRECTED READING THINKING ACTIVITY (DR-TA) STRATEGY TO TEACH READING

    OpenAIRE

    Seftika Seftika

    2016-01-01

    This study aims to investigate the implemetation of Directed Reading Thinking Activity(DR-TA) in enhancing students’ reading comprehension. The process of DR-TAincludes predicting, reading, and proving. This study employed quasi experimetaldesign. As the lecturer guides the process, the DRTA teaches students to determine thepurpose for reading and make adjustments to what they think will come next based onthe text. The finding shows that students’ reading comprehension increased afterapplying...

  6. Doppler transcranien au cours de la drépanocytose chez l'enfant ...

    African Journals Online (AJOL)

    Introduction: Le doppler transcrânien est un outil efficace permettant de dépister les enfants drépanocytaires à risque d'AVC. Méthodes: Nous avons réalisé une étude descriptive transversale sur des enfants Malagasy âgés entre 24 mois et 15 ans (groupe 1: 57 drépanocytaires, groupe 2: 43 témoins) afin d'évaluer le profil ...

  7. Developmental patterns of DR6 in normal human hippocampus and in Down syndrome

    OpenAIRE

    Iyer, Anand; van Scheppingen, Jackelien; Anink, Jasper; Milenkovic, Ivan; Kovács, Gabor G; Aronica, Eleonora

    2013-01-01

    Background Death receptor 6 (DR6) is highly expressed in the human brain: it has been shown to induce axon pruning and neuron death via distinct caspases and to mediate axonal degeneration through binding to N-terminal ? amyloid precursor protein (N-APP). Methods We investigated the expression of DR6 during prenatal and postnatal development in human hippocampus and temporal cortex by immunocytochemistry and Western blot analysis (118 normal human brain specimens; 9 to 41 gestational weeks; 1...

  8. Karakteristik Penderita Konjungtivitis Rawat Jalan di RSUD Dr. Pingadi Medan Tahun 2011

    OpenAIRE

    Hutagalung, Pivit Yunisyah

    2015-01-01

    Cinjunctivitis is inflammation of the conjunctiva or inflammation was largely a mucous membrane that cover the back of the eyelid and eyeball. Conjunctivitis divided into acute and chronic forms. Conjunctivitis is one of the ten greatest diesease in RSUD Dr. Pirngadi Medan. total cases of conjunctivitis and other disorders of conjunctiva 355 visits to the eye departement. To determint the characteristics of patient with conjunctivitis in RSUD Dr.Pirngadi Medan in 2011 with research descrip...

  9. Dr Fabiola Gianotti has been selected by CERN Council to become next CERN Director General

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    With the next Director-General announced, watch the press conference starting in a few minutes via http://cern.ch/webcast/ and send your questions via Twitter to @CERNpressoffice CERN Council selects Italian physicist, Dr Fabiola Gianotti, as CERN’s next Director-General. Dr Gianotti’s mandate will begin on 1 January 2016 and run for a period of five years, read more: http://cern.ch/go/tN09F

  10. Medieindustri og blå blok i parløb mod DR

    DEFF Research Database (Denmark)

    Hjarvard, Stig

    2016-01-01

    Et parløb mellem private medieinteresser og blå blok kan svække public service i almindelighed og DR i særdeleshed, potentielt den største svækkelse af DR siden monopolbruddet i 1988. Men hvorfor vil man svække en offentlig mediesucces i en situation, hvor det private mediemarked er voksende?...

  11. Deinococcus radiodurans Toxin?Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress

    OpenAIRE

    Tao Li; Yulan Weng; Xiaoqiong Ma; Bing Tian; Shang Dai; Ye Jin; Mengjia Liu; Jiulong Li; Jiangliu Yu; Yuejin Hua

    2017-01-01

    Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5′ACA3′, and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A&...

  12. Visit of H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Photo 01: L.to r. Prof. Galileo Violini, Head, UNESCO Office, Teheran; Mr Jan van der Boon, CERN Director of Administration; H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran (signing the Guest Book); Dr John Ellis, CERN Adviser for Non-Member State Relations and Dr Behzad Alipour Tehrany Photo 02: Mr Jan van der Boon, CERN Director of Administration (left) and Dr John Ellis, CERN Adviser for Non-Member State Relations (right) on the occasion of the visit of H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran.

  13. Dr John Dickinson (1832-1863): The man behind the bird.

    Science.gov (United States)

    Conacher, I D

    2016-08-01

    The surgeon/naturalists Dr John Kirk, Dr Charles Meller and Dr John Dickinson, associated with the Zambezi Expedition (1857-1864) under the leadership of Dr David Livingstone are, like him, credited with the discovery of new species' of birds. A raptor, Falco dickinsoni, is named after Dr John Dickinson. Dickinson, born in the north east of England, trained in medicine in Newcastle upon Tyne. He volunteered to join the Universities' Mission to Central Africa and arrived as part of a second group to join Bishop Frederick Mackenzie, then attempting to build a Mission in Magomero, on the Shire Mountain Plateau in modern Malawi. Livingstone and Mackenzie had sown the seeds of disaster for the first UMCA venture while Dickinson was on his way to Central Africa, and his one meeting with Livingstone was trigger to a chain of events that threatened the whole expedition. Shortly after Dickinson's arrival in Magomero, Bishop Mackenzie and a fellow traveller, Reverend Henry de Wint Burrup, died. Magomero was abandoned and the remaining missionaries retrenched in Chibisa's Village on the River Shire. There, where Dickinson did most of his bird collecting, on 17 March 1863, he died of blackwater fever. Livingstone and Kirk were present at the burial. A marble cross at Chikwawa in Malawi is marker to the event that occurred on the day of Dr John Dickinson's 32nd birthday. © The Author(s) 2016.

  14. DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis.

    Science.gov (United States)

    Filatova, Elena Nikolaevna; Anisenkova, Elena Viktorovna; Presnyakova, Nataliya Borisovna; Utkin, Oleg Vladimirovich

    2016-09-01

    Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4+ (nTh) and CD8+ (nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM.

  15. Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients.

    Science.gov (United States)

    Xia, Chenyun; Wang, Mi; Liang, Qi; Yun, Ling'an; Kang, Housheng; Fan, Lei; Wang, Dongsheng; Zhang, Guoyuan

    2014-01-01

    The aim of this study was to investigate changes in human leukocyte antigen (HLA)-DR expression of peripheral blood mononuclear cells (MNCs) in patients with acute organophosphorus pesticide poisoning (AOPP). HLA-DR antigen expression of peripheral blood MNCs was examined in 75 patients with AOPP, including 36 patients without multiple organ dysfunction syndrome (non-MODS) and 39 patients with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy individuals using flow cytometry assay. The associations between HLA-DR antigen expression and certain parameters were analyzed, including acute physiology and chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney function. The mean fluorescence intensity (MCF) of HLA-DR expression in the AOPP group (21.59±5.36) was significantly lower than that in the control group (27.85±4.86) (PDR expression in patients with AOPP was significantly decreased compared with that in healthy individuals; HLA-DR expression may therefore be a good indicator for evaluating AOPP, MODS disease severity, immune function, efficacy of prognosis and prognosis. Examination of HLA-DR antigen expression may be of crucial clinical value.

  16. Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-Associated HLA-DR2 Haplotype1

    Science.gov (United States)

    Sospedra, Mireia; Muraro, Paolo A.; Stefanová, Irena; Zhao, Yingdong; Chung, Katherine; Li, Yili; Giulianotti, Marc; Simon, Richard; Mariuzza, Roy; Pinilla, Clemencia; Martin, Roland

    2009-01-01

    The three HLA class II alleles of the DR2 haplotype, DRB1*1501, DRB5*0101, and DQB1*0602, are in strong linkage disequilibrium and confer most of the genetic risk to multiple sclerosis. Functional redundancy in Ag presentation by these class II molecules would allow recognition by a single TCR of identical peptides with the different restriction elements, facilitating T cell activation and providing one explanation how a disease-associated HLA haplotype could be linked to a CD4+ T cell-mediated autoimmune disease. Using combinatorial peptide libraries and B cell lines expressing single HLA-DR/DQ molecules, we show that two of five in vivo-expanded and likely disease-relevant, cross-reactive cerebrospinal fluid-infiltrating T cell clones use multiple disease-associated HLA class II molecules as restriction elements. One of these T cell clones recognizes >30 identical foreign and human peptides using all DR and DQ molecules of the multiple sclerosis-associated DR2 haplotype. A T cell signaling machinery tuned for efficient responses to weak ligands together with structural features of the TCR-HLA/peptide complex result in this promiscuous HLA class II restriction. PMID:16424227

  17. Hepatotoxicity assessment of the azo dyes disperse orange 1 (DO1), disperse red 1 (DR1) and disperse red 13 (DR13) in HEPG2 cells.

    Science.gov (United States)

    Ferraz, Elisa R A; Li, Zhaohui; Boubriak, Olga; de Oliveira, Danielle P

    2012-01-01

    During the dyeing process in baths approximately 10 to 15% of the dyes used are lost and reach industrial effluents, thus polluting the environment. Studies showed that some classes of dyes, mainly azo dyes and their by-products, exert adverse effects on humans and local biota, since the wastewater treatment systems and water treatment plants were found to be ineffective in removing the color and reducing toxicity of some dyes. In the present study, the toxicity of the azo dyes disperse orange 1 (DO1), disperse red 1 (DR1), and disperse red 13 (DR13) was evaluated in HepG2 cells grown in monolayers or in three dimensional (3D) culture. Hepatotoxicity of the dyes was measured using 3-(4,5-dimethylthiazol-2yl)2,5-diphenyltetrazolium (MTT) and cell counting kit 8 (CCK-8) assays after 24, 48, and 72 h of incubation of cells with 3 different concentrations of the azo dyes. The dye DO1 only reduced the mitochondrial activity in HepG2 cells grown in a monolayer after 72 h incubation, while the dye DR1 showed this deleterious effect in both monolayer and 3D culture. In contrast, dye DR13 decreased the mitochondrial activity after 24, 48, and 72 h of exposure in both monolayer and 3D culture. With respect to dehydrogenase activity, only the dye DR13 diminished the activity of this enzyme after 72 h of exposure in both monolayer and 3D culture. Our results clearly demonstrated that exposure to the studied dyes induced cytotoxicity in HepG2 cells.

  18. [Magnetic resonance imaging versus DR for whole spine imaging in patients with degenerative spinal disease].

    Science.gov (United States)

    Hu, Shao-Yong; Cui, Yun-Neng; Zhao, Yin-Xia; Lu, Ming; Li, Shao-Lin

    2017-09-20

    To assess the quality of whole spine images obtained by DR and magnetic resonance imaging (MRI) and analyze the whole spinal imaging sagittal parameters for standing DR and supine MRI. Sixty-one patients aged 49.9∓17.6 years with degenerative spinal disease underwent both standing DR and supine MRI of the whole spine from November, 2010 to March, 2016. The image quality was retrospectively reviewed, and the cervical lordosis (CL), thoracic kyphosis (TK), lumbar lordosis (LL), sacral slope (SS), and sagittal vertical axis (SVA) were measured on the whole spinal lateral DR and middle sagittal MR images. Both the DR and MR whole spine images had a high quality (100%). The CL, TK, LL, SS, and SVA measured were 28.37mnplus;10.91 °, 29.98mnplus;8.96 °, 45.61mnplus;12.46 °, 34.38mnplus;9.05 °, and 17.20mnplus;26.39 mm on DR images and were 24.34mnplus;9.01 °, 21.22mnplus;8.13 °, 41.45mnplus;12.17 °, 37.45mnplus;8.19 °, and 36.51mnplus;12.44mm on MR images, respectively, showing significant differences in the measurements between the two modalities (P=0.000, 0.000, 0.000, 0.001, and 0.007, respectively). The correlation coefficient between DR and MR images for CL, TK, LL, SS, and SVA were 0.69, 0.68, 0.72, 0.51, and 0.27 (P=0.000, 0.000, 0.000, 0.000, and 0.034, respectively). Both standing DR and supine MR whole spine imaging can provide high-quality images. The CL, TK, LL, SS, and SVA measured on supine MR whole spine images are correlated with those on standing DR images but differ obviously. Supine MR imaging can not substitute standing DR examinations, and comprehensive assessment of degenerative spinal disease needs the combination of the two imaging techniques.

  19. Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.

    Science.gov (United States)

    Kojima, Yuko; Nakayama, Masafumi; Nishina, Takashi; Nakano, Hiroyasu; Koyanagi, Makoto; Takeda, Kazuyoshi; Okumura, Ko; Yagita, Hideo

    2011-12-16

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5)-mediated cell death plays an important role in the elimination of tumor cells and transformed cells. Recently, recombinant TRAIL and agonistic anti-DR5 monoclonal antibodies have been developed and applied to cancer therapy. However, depending on the type of cancer, the sensitivity to TRAIL has been reportedly different, and some tumor cells are resistant to TRAIL-mediated apoptosis. Using confocal microscopy, we found that large amounts of DR5 were localized in the nucleus in HeLa and HepG2 cells. Moreover, these tumor cells were resistant to TRAIL, whereas DU145 cells, which do not have nuclear DR5, were highly sensitive to TRAIL. By means of immunoprecipitation and Western blot analysis, we found that DR5 and importin β1 were physically associated, suggesting that the nuclear DR5 was transported through the nuclear import pathway mediated by importin β1. Two functional nuclear localization signals were identified in DR5, the mutation of which abrogated the nuclear localization of DR5 in HeLa cells. Moreover, the nuclear transport of DR5 was also prevented by the knockdown of importin β1 using siRNA, resulting in the up-regulation of DR5 expression on the cell surface and an increased sensitivity of HeLa and HepG2 cells to TRAIL. Taken together, our findings suggest that the importin β1-mediated nuclear localization of DR5 limits the DR5/TRAIL-induced cell death of human tumor cells and thus can be a novel target to improve cancer therapy with recombinant TRAIL and anti-DR5 antibodies.

  20. DR AVRAM JOZEF VINAVER (1862-1915) - PIONEER OF RADIOLOGY IN SERBIA.

    Science.gov (United States)

    Babić, Rade Radomir; Stanković Babić, Gordana

    2015-01-01

    Dr Abraham Joseph Vinaver (1862-1915), a Jew from Poland, was a pioneer of radiology in Serbia. He graduated from the Faculty of Medicine in Warsaw (1887), but lived and worked in abac (the Kingdom of Serbia) since 1890. Dr Abraham Joseph Vinarev - Career Development. He procured the first X-ray machine and developed radiological service in Sabac five years after the discovery of X-rays. These were the beginnings of radiology in Serbia. He introduced the application of artesian wells. Dr Abraham Joseph Vinarev - a Participant at the First Congress of Serbian Physicians and Naturalists, Belgrade 1904. "The diagnostic importance of X-rays in lung disease, especially in initial tuberculosis" and "Five Years of Treatment by X-Ray Machines" were the first works in the field of radiology in Serbia by this author. Dr Abraham Joseph Vinaver - Reserve Medical Officer in the Serbian Army. During the Balkan Wars, he was a volunteer with the rank of major engaged in military corps and he participated in the First World War as well. He died of malaria in 1915 in Gevgelija. "Dr Avram Vinaver"- Stanislav Vinarev. His dedication to work during the typhus epidemics was put into verses of a poem by his son Stanislav Vinarev. Dr Avram Vinaver Joseph was a noble man with a great heart, who selflessly sacrificed himself for the Serbian people and Serbia. He gave his contribution to the development of health services in Serbia, both in peacetime and wartime conditions. Dr Abraham Joseph Vinaver laid the foundations for today's radiology in Serbia.

  1. drFrnE Represents a Hitherto Unknown Class of Eubacterial Cytoplasmic Disulfide Oxido-Reductases.

    Science.gov (United States)

    Bihani, Subhash C; Panicker, Lata; Rajpurohit, Yogendra S; Misra, Hari S; Kumar, Vinay

    2017-10-16

    Living cells employ thioredoxin and glutaredoxin disulfide oxido-reductases to protect thiol groups in intracellular proteins. FrnE protein of Deinococcus radiodurans (drFrnE) is a disulfide oxido-reductase that is induced in response to Cd(2+) exposure and is involved in cadmium and radiation tolerance. The aim of this study is to probe structure, function, and cellular localization of FrnE class of proteins. Here, we show drFrnE as a novel cytoplasmic oxido-reductase that could be functional in eubacteria under conditions where thioredoxin/glutaredoxin systems are inhibited or absent. Crystal structure analysis of drFrnE reveals thioredoxin fold with an alpha helical insertion domain and a unique, flexible, and functionally important C-terminal tail. The C-tail harbors a novel 239-CX4C-244 motif that interacts with the active site 22-CXXC-25 motif. Crystal structures with different active site redox states, including mixed disulfide (Cys22-Cys244), are reported here. The biochemical data show that 239-CX4C-244 motif channels electrons to the active site cysteines. drFrnE is more stable in the oxidized form, compared with the reduced form, supporting its role as a disulfide reductase. Using bioinformatics analysis and fluorescence microscopy, we show cytoplasmic localization of drFrnE. We have found "true" orthologs of drFrnE in several eubacterial phyla and, interestingly, all these groups apparently lack a functional glutaredoxin system. Innovation and Conclusion: We show that drFrnE represents a new class of hitherto unknown intracellular oxido-reductases that are abundantly present in eubacteria. Unlike other well-known oxido-reductases, FrnE harbors an additional dithiol motif that acts as a conduit to channel electrons to the active site during catalytic turnover. Antioxid. Redox Signal. 00, 000-000.

  2. Phenotypic and functional characteristics of HLA-DR+neutrophils in Brazilians with cutaneous leishmaniasis.

    Science.gov (United States)

    Davis, Richard E; Sharma, Smriti; Conceição, Jacilara; Carneiro, Pedro; Novais, Fernanda; Scott, Phillip; Sundar, Shyam; Bacellar, Olivia; Carvalho, Edgar M; Wilson, Mary E

    2017-03-01

    The protozoan Leishmania braziliensis causes cutaneous leishmaniasis (CL) in endemic regions. In murine models, neutrophils (PMNs) are recruited to the site of infection soon after parasite inoculation. However, the roles of neutrophils during chronic infection and in human disease remain undefined. We hypothesized that neutrophils help maintain a systemic inflammatory state in subjects with CL. Lesion biopsies from all patients with CL tested contained neutrophils expressing HLA-DR, a molecule thought to be restricted to professional antigen-presenting cells. Although CL is a localized disease, a subset of patients with CL also had circulating neutrophils expressing HLA-DR and the costimulatory molecules CD80, CD86, and CD40. PMNs isolated from a low-density leukocyte blood fraction (LD-PMNs) contained a higher percentage of HLA-DR + PMNs than did normal-density PMNs. In vitro coculture experiments suggested LD-PMNs do not suppress T cell responses, differentiating them from MDSCs. Flow-sorted HLA-DR + PMNs morphologically resembled conventional PMNs, and they exhibited functional properties of PMNs. Compared with conventional PMNs, HLA-DR + PMNs showed increased activation, degranulation, DHR123 oxidation, and phagocytic capacity. A few HLA-DR + PMNs were observed in healthy subjects, and that proportion could be increased by incubation in either inflammatory cytokines or in plasma from a patient with CL. This was accompanied by an increase in PMN hladrb1 mRNA, suggesting a possible connection between neutrophil "priming" and up-regulation of HLA-DR. These data suggest that PMNs that are primed for activation and that also express surface markers of antigen-presenting cells emerge in the circulation and infected tissue lesions of patients with CL. © Society for Leukocyte Biology.

  3. Assessment of DR-55 as a Drop-In Replacement for R-410A

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [ORNL; Abdelaziz, Omar [ORNL

    2016-01-01

    R410A has no ozone depletion potential (ODP), and is the most commonly used refrigerant in vapor compression systems for space cooling and heating applications. However, it has significant global warming potential with GWP higher than 1900. To mitigate the global warming effect, industry and research institutes are actively pursuing a replacement for R-410A with the following attributes, much lower GWP along with similar or higher efficiency and capacity. DR-55 (aka R452B) is a design-compatible refrigerant replacement for R-410A. It decreases the GWP by 70%, and has lower working pressure, comparable discharge temperature, and uses the same lubricant, tubing, and valves. In this study, we experimentally evaluated the performance of DR-55 as a drop-in replacement for R-410A in a high efficiency rooftop air conditioning unit. The experimental results demonstrated that DR-55 led to 5% higher efficiency at the working conditions of Integrated Energy Efficiency Rating (IEER). DR-55 also showed significantly better high ambient performance from 95 F to 125 F. In addition to the experimental study, we used the DOE/ORNL Heat Pump Design Model to model the RTU using R-410A and DR-55, respectively. The model results were compared to the laboratory measurements. The model validation demonstrates that the refrigerant heat transfer and pressure drop correlations, developed for conventional refrigerants like R-410A, are usable for DR-55. Also, a converted compressor model for DR-55, i.e. reducing volumetric and isentropic efficiencies as a function of the suction and discharge pressures from an R-410A compressor map can predict the compressor mass flow rate and power accurately.

  4. HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients.

    Science.gov (United States)

    Dunne, Margaret R; Michielsen, Adriana J; O'Sullivan, Katie E; Cathcart, Mary Clare; Feighery, Ronan; Doyle, Brendan; Watson, Jenny A; O'Farrell, Naoimh J; Ravi, Narayanasamy; Kay, Elaine; Reynolds, John V; Ryan, Elizabeth J; O'Sullivan, Jacintha

    2017-07-01

    Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis, and incidence is increasing rapidly in the Western world. Measurement of immune markers has been shown to have prognostic significance in a growing number of cancers, but whether this is true for EAC has yet to be evaluated. This study aimed to characterize HLA-DR expression in the esophagus across the inflammation to cancer progression sequence and to assess the prognostic significance of HLA-DR expression in EAC. Tissue microarrays (TMA) were constructed from esophageal tissue taken from patients at different stages in the cancer progression sequence; normal, esophagitis, Barrett's esophagus (BE), low- and high-grade dysplasia (LGD, HGD) and EAC. HLA-DR expression in tissue epithelium and stroma was assessed by immunohistochemistry. HLA-DR expression increased early in the inflammation to cancer progression sequence; with higher expression detected in esophagitis and BE compared to normal tissue. Patients with low (DR expression in the EAC tumor epithelium had significantly worse survival outcomes, compared to those with high expression, in both the tumor core (hazard ratio, HR = 2.178, p = 0.024, n = 70) and leading edge (HR = 2.86, p = 0.013, n = 41). Multivariate analysis demonstrated that low HLA-DR expression in leading edge tumor epithelium was an independent predictor of poor survival, associated with a 2.8-fold increase in disease-associated death (p = 0.023). This study shows that HLA-DR is an independent prognostic marker in EAC tumor epithelium. This may have implications for patient stratification strategies as well as EAC tumor immunology.

  5. Dr Oen Boen Ing Patriot doctor, social activist, and doctor of the poor

    Directory of Open Access Journals (Sweden)

    Ravando Lie

    2017-05-01

    Full Text Available This article examines the efforts and achievements of Oen Boen Ing, a Tionghoa doctor, to improve the quality of health of the poorer inhabitants of Surakarta. Dr Oen played an important role in five different periods: Dutch colonialism, the Japanese occupation, the Indonesian revolution, Soekarno’s regime, and Suharto’s New Order. Known for being a benevolent doctor, activist, and patriot of the revolution during his life-time, Dr Oen also gave medical assistance to the needy, which famously earned him the accolade of “doctor of the poor”. During the Indonesian revolution, Dr Oen assisted the Student Soldiers (Tentara Pelajar and afterwards was appointed the member of Supreme Advisory Council (Dewan Pertimbangan Agung/DPA by Soekarno in 1949. As a benevolent doctor and activist, Dr Oen is remembered for founding the Panti Kosala Hospital which was renamed to perpetuate his name on 30 October 1983, exactly a year after his passing. When he died, thousands of peoples gathered to pay their final respects to the doctor. He was honoured with a ceremony conducted in the Mangkunegaran Palace. Dr Oen’s name will be eternally respected, especially in Surakarta.

  6. Principles of plastic surgery portrayed by the professional life of Dr John Peter Mettauer.

    Science.gov (United States)

    Avashia, Yash J; Thaller, Seth R

    2011-11-01

    Regarded as "America's first plastic surgeon," Dr John Peter Mettauer's professional life displays 3 fundamental keystones of plastic surgery: education, innovation, and practice. To fully appreciate the history of our plastic surgery, one must look beyond a purely factual recount of noteworthy actions performed decades ago. Fundamental principles that governed achievements of our predecessors remain applicable even today. Dr Mettauer thrived as a medical student under the influence of distinguished professors in medicine at the University of Pennsylvania. Later, he continued to propagate their basic tenets when he established his medical institute in 1837. Throughout his life, Dr Mettauer combined ingenuity with scientific inquiry to devise numerous unprecedented surgical techniques and instruments. He was a prolific writer and exquisitely documented his work in medical journals for the benefit of both contemporary and future surgeons. One of Dr Mettauer's momentous achievements in plastic surgery that displays his remarkable capabilities was his contributions to management of both simple and complicated cases of cleft palate. He was the first to describe relaxing lateral incisions for treating complete cleft palates and, incidentally, was the first to successfully treat this in America. He invariably replicated similar success in establishing techniques for treating a wide range of anatomic deformities. Cumulatively, Dr Mettauer's lifelong commitment and diligence have truly laid a foundation for the eventual progress and success in the field of plastic surgery.

  7. HLA-DR alleles associated with skin warts induced by human papillomavirus infection.

    Science.gov (United States)

    García-Corona, Cristina; Vega-Memije, Elisa; Barquera, Rodrigo; Granados, Julio

    2010-12-01

    The skin wart is a benign proliferation of the skin and mucous, secondary to human papillomavirus (HPV) infection. The objective of this study is to determine gene frequencies of HLA-DR alleles in Mexican patients with skin warts and compare them with those present in ethnically matched healthy subjects. Fifty-two patients with clinically and histologically confirmed skin warts from the Dermatology Outpatient Clinic, with results of high-resolution DNA typing for HLA-DR polymorphism. HLA-DR3 and DR9 were increased (P = 0.0029, OR: 2.5, 95% CI: 1.3–4.7 and P = 0.0062, OR: 5.4, 95% CI: 1.4–19.5, respectively), and HLA-DR6 allele was found decreased (P = 0.0002). The major histocompatibility complex contribution in the infection and elimination of the virus is not clear and perhaps also contributes to a series of events not well established yet. This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.

  8. Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

    Directory of Open Access Journals (Sweden)

    Furuya Toshio

    2011-02-01

    Full Text Available Abstract Background The amount of data on protein-protein interactions (PPIs available in public databases and in the literature has rapidly expanded in recent years. PPI data can provide useful information for researchers in pharmacology and medicine as well as those in interactome studies. There is urgent need for a novel methodology or software allowing the efficient utilization of PPI data in pharmacology and medicine. Results To address this need, we have developed the 'Druggable Protein-protein Interaction Assessment System' (Dr. PIAS. Dr. PIAS has a meta-database that stores various types of information (tertiary structures, drugs/chemicals, and biological functions associated with PPIs retrieved from public sources. By integrating this information, Dr. PIAS assesses whether a PPI is druggable as a target for small chemical ligands by using a supervised machine-learning method, support vector machine (SVM. Dr. PIAS holds not only known druggable PPIs but also all PPIs of human, mouse, rat, and human immunodeficiency virus (HIV proteins identified to date. Conclusions The design concept of Dr. PIAS is distinct from other published PPI databases in that it focuses on selecting the PPIs most likely to make good drug targets, rather than merely collecting PPI data.

  9. An HPLC method associated with a thermodynamic analysis to compare the binding of TRAIL and its nanovectorized form to death receptors DR4 and DR5 and their relationship to cytotoxicity.

    Science.gov (United States)

    Guillaume, Yves Claude; Lethier, Lydie; André, Claire

    2016-11-15

    TRAIL is a member of the TNF family of cytokines which induces apoptosis of cancer cells via its binding to its cognate receptors, DR5 a high affinity site and DR4 a site of low affinity. Our working group has recently demonstrated that nanovectorization of TRAIL with single wall carbon nanotubes (abbreviated NPT) enhanced TRAIL affinity to the high affinity site DR5 and increased pro apoptotic potential in different human tumor cell lines. In this paper, the DR4 low affinity site was immobilized on a chromatographic support and the effect of temperature on a wide temperature range 1°C-50°C was studied to calculate the thermodynamic parameters of the binding of TRAIL and NPT to DR4 and DR5 receptors. For the first time the heat capacity changes for the different binding processes were determined. At a physiological pH (7.4) the heat capacity changes for the binding of NPT to DR4 and DR5 were respectively equal to -0.91kJ/molK and -0.28kJ/molK and those obtained for the binding of TRAIL to DR4 and DR5 were respectively equal to -1.54kJ/molK and -1.05kJ/molK. By the use of differential scanning calorimetry (DSC), a phase transition (∼12°C for DR5, ∼4°C for DR4) between a disordered (low temperature) and an ordered (high temperature) solid like state visualized in the receptor structure confirmed the temperature dependence of binding affinity enthalpy ΔH for soluble TRAIL and its nanovectorized form to its cognate receptors. In the low temperature domain, the positive ΔH values contribute non-favourably to the free energy of binding, TRAIL and NPT described similar affinities for DR4 and DR5. For the high temperature domain, negative ΔH values indicated that van der Waals interactions and hydrogen bonding are engaged favourably at the ligand - receptor interface. Above 30°C, their rank-ordered affinities were thus strongly different in the sequence: TRAILDR4DR4 and DR5

  10. Modeling Dr. Dynasaur 2.0 Coverage and Finance Proposals: Effects of the Expansion of Vermont's Dr. Dynasaur Program to All Individuals Through Age 25.

    Science.gov (United States)

    Dick, Andrew W; Price, Carter C; Woods, Dulani; Freund, Deborah Anne; McNamara, Martin; Schramm, Steven P; Berkman, Elrycc; Dehner, Tom

    2017-01-01

    The authors assessed an expansion of Vermont's Dr. Dynasaur program that would cover all residents age 25 and younger. The current Dr. Dynasaur program combines Vermont's Medicaid program and Child Health Insurance Program for children ages 0 through 18 to provide a seamless insurance program for those with family incomes below 317 percent of the federal poverty level. The authors used RAND's COMPARE-VT microsimulation model with Vermont-specific demographic, economic, and actuarial data to estimate the effects on health insurance coverage, costs, and premiums. They also identified the new revenues required to fund the program expansion and explored three alternative financing strategies to raise those funds: (1) an increase in the Vermont income tax, (2) a Vermont payroll tax, and (3) a Vermont business enterprise tax. The authors found that enrollment would increase by more than 260 percent under the 100-percent enrollment scenario and by nearly 200 percent under the 70-percent enrollment scenario by 2019. Not surprisingly, the children and young adults who move off employer-sponsored insurance (ESI) and into Dr. Dynasaur 2.0 have considerably lower expected health care costs than those who remain on ESI, increasing the per-person premiums by nearly $1,000 for those remaining enrolled in ESI. Annual health care expenditures per person for children and young adults in 2019 are estimated at $4,325 with Medicare prices. The combination of increased reimbursement rates, large increases in enrollment, and relatively low Dr. Dynasaur premiums (no more than $720 per year) will require significant new tax revenues to meet program obligations.

  11. Strong association of antiepithelial cell antibodies with HLA-DR3 or DR7 phenotype in patients with recurrent oral ulcers.

    Science.gov (United States)

    Sun, A; Hsieh, R P; Liu, B Y; Wang, J T; Leu, J S; Wu, Y C; Chiang, C P

    2000-04-01

    Previous studies showed that antiepithelial cell antibodies (anti-ECA) were present in 71% (15/21) of patients with recurrent oral ulcers (ROU) and that there was a strong association of human leukocyte antigen (HLA)-DRw9 with ROU in Chinese patients. In this study, we assessed anti-ECA in a larger group of Chinese patients with ROU (n = 88) in order to further investigate the association of anti-ECA with HLA-DR and -DQ antigens. The anti-ECA in the sera of ROU patients were detected by an indirect immunofluorescence technique with rat esophagus as the substrate, and the HLA-DR and -DQ antigens in ROU patients were typed by a standard microcytotoxicity assay using Terasaki's oriental tray. The rate of anti-ECA positivity was significantly higher (p ECA positivity in patients with major or minor oral ulcers (72%) was significantly higher (29%) than that in patients with herpetiform ulcers (p ECA-positive ROU patients compared with the corresponding frequencies in healthy control subjects. There was also a significant increase in the frequency of DR7 or DRw9 antigen expression (p ECA-positive than in anti-ECA-negative ROU patients (p ECA in Chinese patients with ROU.

  12. Targeting the Apoptotic Pathway in Chondrosarcoma Using Recombinant Human Apo2L/TRAIL (dulanermin), a Dual Pro-apoptotic Receptor (DR4/DR5) Agonist

    Science.gov (United States)

    Subbiah, Vivek; Brown, Robert E; Buryanek, Jamie; Trent, Jonathan; Ashkenazi, Avi; Herbst, Roy; Kurzrock, Razelle

    2012-01-01

    Recombinant human Apo2L/TRAIL (dulanermin) is based on the ligand for death receptors (DR4 and DR5), which promotes apoptosis. We report a patient with refractory chondrosarcoma who demonstrated a prolonged response to dulanermin, and explore mechanisms of response and resistance. This heavily pretreated patient had progressive metastatic chondrosarcoma to the lung. On dulanermin (8 mg/kg IV on days 1 through 5 in a 21-day cycle) the patient achieved a sustained partial response with only sub-centimeter nodules remaining. After 62 months of dulanermin treatment, progressive disease in the lungs was noted, and the patient underwent a resection that confirmed chondrosarcoma. DR4 was detected (immunohistochemistry) in the patient’s tumor, which may have enabled the response. However, up-regulation of pro-survival proteins, namely, phosphorylated (p)-NF-kappaBp65 (Ser 536), p-STAT3 (Tyr 705), pERK 1/2 (Thr 202/Tyr 204), p-mTOR (Ser 2448), FASN and Bcl-2, was also detected, which may have provided the underlying mechanisms for acquired dulanermin resistance. The patient was restarted on dulanermin and has continued on this treatment for an additional 16 months since surgery (78 months since initiation of treatment), with his most recent CT scans showing no evidence of disease. PMID:22914439

  13. DIRECTED READING THINKING ACTIVITY (DR-TA STRATEGY TO TEACH READING

    Directory of Open Access Journals (Sweden)

    Seftika Seftika

    2016-09-01

    Full Text Available This study aims to investigate the implemetation of Directed Reading Thinking Activity(DR-TA in enhancing students’ reading comprehension. The process of DR-TAincludes predicting, reading, and proving. This study employed quasi experimetaldesign. As the lecturer guides the process, the DRTA teaches students to determine thepurpose for reading and make adjustments to what they think will come next based onthe text. The finding shows that students’ reading comprehension increased afterapplying Directed Reading Thinking Activity( DR-TA. By using this strategy studentscan activate their prior knowledge of a topic/content of the text to be read, hypothesizeabout what might be addressed in the text, and establish meaningful purposes forreading the text.Keywords: Directed Reading Thinking Activity strategy, reading, comprehension.

  14. VizieR Online Data Catalog: Mira stars discovered in LAMOST DR4 (Yao+, 2017)

    Science.gov (United States)

    Yao, Y.; Liu, C.; Deng, L.; de Grijs, R.; Matsunaga, N.

    2017-10-01

    By the end of 2016 March, the wide-field Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST) DR4 catalog had accumulated 7681185 spectra (R=1800), of which 6898298 were of stars. We compiled a photometrically confirmed sample of Mira variables from the Kiso Wide-Field Camera (KWFC) Intensive Survey of the Galactic Plane (KISOGP; Matsunaga 2017, arXiv:1705.08567), the American Association of Variable Star Observers (AAVSO) International Database Variable Star Index (VSX; Watson 2006, B/vsx, version 2017-05-02; we selected stars of variability type "M"), and the SIMBAD Astronomical Database. We first cross-matched the KISOGP and VSX Miras with the LAMOST DR4 catalog. Finally, we cross-matched the DR4 catalog with the SIMBAD database. See section 2. (1 data file).

  15. Predictive analysis for prognosis of CD14+ monocyte HLA-DR in geriatric trauma patients

    Directory of Open Access Journals (Sweden)

    Jie-fu LU

    2016-08-01

    Full Text Available Objective  To evaluate the prognostic roles of HLA-DR+/CD14+ expression rate in peripheral blood monocytes in geriatric trauma sepsis. Methods  A retrospective study of clinical data was carried out. Clinical data of geriatric trauma patients (age≥60 years admitted to intensive care unit (ICU of Guangzhou General Hospital of Guangzhou Command from January 2011 to December 2015 were collected. The expressions of HLA-DR+/CD14+, procalcitonin (PCT and C-reactive protein (CRP were detected within 24 hours after admission. Spearman correlation analysis was adopted to analyze the correlation between the HLADR+/CD14+ and the length of ICU stay, and between the length of stay and APACHE Ⅱ. Receiver operating characteristic (ROC curve was used to evaluate the prognostic roles of HLA-DR+/CD14+ expression, PCT, CRP and APACHE Ⅱscore. Results  There were significant differences between survivors and nonsurvivors in APACHE Ⅱscore (17.49±6.25 vs 27.38±8.68, P<0.05 and the expressions of HLA-DR+/CD14+ (59.80±18.02 vs 37.70±13.96, P<0.01. There were significant differences between sepsis and non-sepsis in APACHEⅡscore (26.16±8.44 vs 17.90±7.04, P<0.01 and the expressions of HLA-DR+/CD14+ (38.61±14.48 vs 59.79±18.17, P<0.01, PCT (34.45±68.29 vs 4.25±8.26, P<0.01 and CRP (129.88±103.25 vs 76.04±73.48, P<0.011. There existed a negative relationship between the HLA-DR+/CD14+ and length of ICU stay (r=–0.304, P=0.008, and APACHE Ⅱ(r=–0.559, P=0.000. There was no significant relationship between the HLA-DR+/CD14+ and length of stay (r=0.188, P=0.106. By ROC for sepsis prognosis, the area under the curve (Mean±SE of HLA-DR+/CD14+ was 0.807±0.051 (95%CI 0.706-0.907, P=0.000, the AU-ROC (Mean±SE of PCT was 0.714±0.063 (95% CI:0.591-0.837, P=0.003. The best cut-off for HLA-DR+/ CD14+ was 40%, with the sensitivity of 88.0% and specificity of 60.0%.The best cut-off for PCT was 1.01, with the sensitivity of 84.0% and specificity of 65

  16. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    Science.gov (United States)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  17. Pressure loss tests for DR-BEP of fullsize 17 x 17 PWR fuel assembly

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Moon Ki; Chun, Se Young; Chang, Seok Kyu; Won, Soon Youn; Cho, Young Rho; Kim, Bok Deuk; Min, Kyoung Ho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1993-01-01

    This report describes the conditions, procedure and results in the pressure loss tests carried out for a double grid type debris resistance bottom end piece (DR-BEP) designed by KAERI. In this test, the pressure loss coefficients of the full size 17 x 17 PWR simulated fuel assembly with DR-BET and with standard-BEP were measured respectively, and the pressure loss coefficients of DR-BEP were compared with the coefficients of STD-BET. The test conditions fall within the ranges of loop pressure from 5.2 to 45 bar, loop temperature from 27 to 221 deg C and Reynolds number in fuel bundle from 2.17 x 10{sup 4} to 3.85 x 10{sup 5}. (Author) 5 refs., 18 figs., 5 tabs.

  18. The Case of Dr. Oz: Ethics, Evidence, and Does Professional Self-Regulation Work?

    Science.gov (United States)

    Tilburt, Jon C; Allyse, Megan; Hafferty, Frederic W

    2017-02-01

    Dr. Mehmet Oz is widely known not just as a successful media personality donning the title "America's Doctor ® ," but, we suggest, also as a physician visibly out of step with his profession. A recent, unsuccessful attempt to censure Dr. Oz raises the issue of whether the medical profession can effectively self-regulate at all. It also raises concern that the medical profession's self-regulation might be selectively activated, perhaps only when the subject of professional censure has achieved a level of public visibility. We argue here that the medical profession must look at itself with a healthy dose of self-doubt about whether it has sufficient knowledge of or handle on the less visible Dr. "Ozes" quietly operating under the profession's presumptive endorsement. © 2017 American Medical Association. All Rights Reserved.

  19. [Dr. Puigvert and Archivos Españoles de Urología].

    Science.gov (United States)

    Pérez Albacete, Mariano

    2006-04-01

    For the celebration of the first Century of Dr. Antonio Puigvert Gorro's birth we want to know his contribution to and relationship with Archivos Españoles de Urología. We review all articles published by Dr. Puigvert, and additionally all articles with reference to his person and his work; we also review his written works and biography. He was one of the founders of the journal and always maintained a great cooperation until the '70s; he published important works in it, which are analyzed. We also emphasize his contribution to Urology in addition to his dedication to the history of the speciality. Dr. Puigvert is one of the most distinguished figures in the Spanish Urology, with an immense working capacity and written works. In his works published in Archivos he presents the results of his observations and his studies, as well as part of his innovations, ideas, and discoveries, that he later left in his urology books.

  20. BEopt-CA (Ex): A Tool for Optimal Integration of EE, DR and PV in Existing California Homes

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, Craig [National Renewable Energy Lab. (NREL), Golden, CO (United States); Horowitz, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Maguire, Jeff [National Renewable Energy Lab. (NREL), Golden, CO (United States); Velasco, Paulo Tabrares [National Renewable Energy Lab. (NREL), Golden, CO (United States); Springer, David [Davis Energy Group, Davis, CA (United States); Coates, Peter [Davis Energy Group, Davis, CA (United States); Bell, Christy [Davis Energy Group, Davis, CA (United States); Price, Snuller [Energy & Environmental Economics, San Francisco, CA (United States); Sreedharan, Priya [Energy & Environmental Economics, San Francisco, CA (United States); Pickrell, Katie [Energy & Environmental Economics, San Francisco, CA (United States)

    2014-04-01

    This project targeted the development of a software tool, BEopt-CA (Ex) (Building Energy Optimization Tool for California Existing Homes), that aims to facilitate balanced integration of energy efficiency (EE), demand response (DR), and photovoltaics (PV) in the residential retrofit1 market. The intent is to provide utility program managers and contractors in the EE/DR/PV marketplace with a means of balancing the integration of EE, DR, and PV

  1. Pitanje kontinuiteta Republike Hrvatske s državama prethodnicama na njezinom području

    OpenAIRE

    Degan, Vladimir-Đuro; Barić Punda, Vesna

    2017-01-01

    Povod za ovu raspravu jest skupna tužba (Class Action Complaint) koju je grupa nasljednika i rodbine hrvatskih Židova, Srba i Roma podnijela protiv Republike Hrvatske 31. svibnja 2016. godine Okružnom sudu Sjedinjenih Država za Sjeverni okrug Istočnoga područja Illinoisa. Tužba se zasniva na tvrdnji o apsolutnom identitetu i kontinuitetu Republike Hrvatske s tzv. „Nezavisnom Državom Hrvatskom“ iz Drugog svjetskog rata. U tužbi se od Republike Hrvatske traži odšteta za pretrpljene gubitke žrta...

  2. Dr. Kenneth Plotkins Myriad Contribution to the National Aeronautics and Space Administrations Supersonic Mission

    Science.gov (United States)

    Haering, Edward A.

    2017-01-01

    The world as a whole and NASA in particular, owes a large debt of gratitude to Dr. Kenneth Plotkin for his decades of service in the field of sonic boom research and advancement of quiet supersonic transportation. This presentation will highlight the contributions of Dr. Plotkin to a myriad of NASA projects. One of the largest efforts was the assembly and continual improvement of sonic boom propagation software tools, collectively called PCBoom, which allowed the analysis of real and imagined vehicles from Mach cutoff conditions to the hypersonic.

  3. MASTER AND PUPIL – DR. JÁN BRTEK AND I

    Directory of Open Access Journals (Sweden)

    Hidetoshi NAGANAWA

    2008-06-01

    Full Text Available Large branchiopod studies were born and bred in the Danube basin in some Eastern European countries (the former Czechoslovakia, Hungary, and Romania. The leading expert was the late Dr. Ján Brtek in Slovakia. Large branchiopods are usually habitants of such temporary lakes and ponds as inland bodies of fresh, mineralized, salt water or hypersaline. This article has two distinct goals: (1 to review the history of large branchiopod studies and (2 to draw attention to some of the scientific interest and value of ephemeral aquatic habitats, introducing my reminiscences of Dr. Brtek.

  4. Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics.

    Science.gov (United States)

    Jones, Dennis

    2011-06-01

    Genetic engineering is the process of modifying an organism's genetic composition by adding foreign genes to produce desired traits or evaluate function. Dr. Jon W. Gordon and Sterling Professor Emeritus at Yale Dr. Frank H. Ruddle were pioneers in mammalian gene transfer research. Their research resulted in production of the first transgenic animals, which contained foreign DNA that was passed on to offspring. Transgenic mice have revolutionized biology, medicine, and biotechnology in the 21st century. In brief, this review revisits their creation of transgenic mice and discusses a few evolving applications of their transgenic technology used in biomedical research.

  5. Laryngology in Art: The Portrait of Dr Wilhelm Mayer-Hermann.

    Science.gov (United States)

    Patel, Amit A

    2016-12-01

    Otto Dix's portrait of the laryngologist Dr Wilhelm Mayer-Hermann represents a shining example of Neue Sachlichkeit, or New Objectivity, offering a return to unsentimental reality and a focus on the objective world, as opposed to the more abstract and idealistic tendencies of expressionism. However, precious little is known about the subject of the portrait. This article examines the portrait and attempts to shed light on the life and career of the Dr Wilhelm Mayer-Hermann. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.

  6. Counter-Checking Tycho Double Stars with the SDSS DR9 Catalog

    Science.gov (United States)

    Knapp, Wilfried

    2017-01-01

    As already reported (Knapp and Gould 2016), most Tycho Double Star objects in the WDS catalog are unconfirmed. Small separation and faint components make these objects hard to resolve either by visual observation or by imaging in the V-band and only few public domain star catalogs offer resolution for stars with less than 2-3 arcseconds. One exception is the SDSS DR9 catalog based on images with a resolution of 0.396 arcseconds per pixel. This report shows that SDSS DR9 is of good use for counter-checking double stars down to a separation of 1.5 arcseconds or even less.

  7. Doppler transcranien au cours de la drépanocytose chez l'enfant Malagasy

    Science.gov (United States)

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Rakoto, Olivat Aimée Alson; Ahmad, Ahmad

    2016-01-01

    Introduction Le doppler transcrânien est un outil efficace permettant de dépister les enfants drépanocytaires à risque d'AVC. Méthodes Nous avons réalisé une étude descriptive transversale sur des enfants Malagasy âgés entre 24 mois et 15 ans (groupe 1: 57 drépanocytaires, groupe 2: 43 témoins) afin d’évaluer le profil vélocimétrique des artères cérébrales chez les drépanocytaires. Un examen Doppler transcrânien a été réalisé avec étude des flux sanguins cérébraux chez les enfants des deux groupes. Résultats Pour les sujets drépanocytaires, la vitesse moyenne (VM) de l'artère cérébrale moyenne était de 100,9 ± 26,8 cm/s, l'indice de pulsatilité (IP) de 0,73 ± 0,20, la différence entre les artères cérébrales moyennes droite et gauche (ACMr) de 19,8 ± 21,5 cm/s, le rapport des vitesses de l'artère cérébrale antérieure/artère cérébrale moyenne (ACA/ACM) de 0,7 ± 0,2. Pour les enfants non drépanocytaires, VM: 80,6 ± 19,3 cm/s, IP: 0,79 ± 0,14, ACMr: 17 ± 20,1 cm/s, ACA/ACM: 0,8 ± 0,2. La vélocité des enfants drépanocytaires était supérieure au groupe contrôle. Les vitesses ont été corrélées avec le taux d'hémoglobine et l’âge et non pas avec le sexe et le volume globulaire moyen. Conclusion Les vitesses circulatoires cérébrales sont élevées chez les drépanocytaires que les enfants non drépanocytaires et sont influencées par le taux d'hémoglobine et l’âge. PMID:27516829

  8. Drácula y el principio de hospitalidad: Una revisión conceptual

    OpenAIRE

    Maximiliano KORSTANJE

    2016-01-01

    El presente ensayo cuestiona no solo a los estudios vigentes sobre el arquetipo del Conde Drácula ya que la mayoría de ellos intentan su comprensión por medio de sus características personales tales como ser no vivo, con autoridad, sediento de sangre humana, sino que además provee una explicación filosófica que permite una lectura profunda del mal como la falta total de hospitalidad. Drácula es uno de los villanos más temidos de occidente porque seduce a sus víctimas bajo el pr...

  9. [Study of anti-DR antibodies in sterility and infertility (author's transl)].

    Science.gov (United States)

    Balasch, J; Vanrell, J A; González-Merlo, J; Ercilla, M G; Vives, J; Castillo, R

    1980-01-01

    The presence of anti-DR antibodies with lymphocyte cytotoxicity test was studied in five groups of patients: 50 males with no history of blood transfusions who comprised the control group, 44 contraceptive-using women, 55 pregnant women, 41 primary sterile and 47 infertile patients. The high and similar degree of sensitization found in both pregnant and sterile patients lead us to the conclusion that anti-DR antibodies are not a cause of sterility and that spermatozoa are highly immunogenic. The biological significance of the antibodies is discussed.

  10. Expression of HLA-DR/CD14 on peripheral blood mononuclear cells and its clinical significance

    Directory of Open Access Journals (Sweden)

    Wei LI

    2011-01-01

    Full Text Available Objective To investigate the HLA-DR/CD14 expression on the surface of peripheral blood mononuclear cell and its clinical significance.Methods One hundred and forty patients hospitalized from Apr.2008 to Apr.2009 were involved in present study,including 101 of acute and severe cases and 39 other cases,while 20 persons undergoing health examination were involved as control.The expression rate of HLA-DR/CD14 on peripheral blood mononuclear cells was detected by flow cytometry,and the serum level of C-reactive protein(CRP in acute and severe group was determined,and the correlation between HLA-DR/CD14 expression rate and CRP level was analyzed.Meanwhile,15 cases were selected from acute and severe group,the expression rate of HLA-DR/CD14 on peripheral blood mononuclear cells at 1,4,8,12,16 and 20 days after emergency hospitalization was determined and its relation to disease courses and clinical symptoms was dynamically observed.Results The expression rate of HLA-DR/CD14 was markedly lower in acute and severe group(38.64%±14.15% than in other disease group(56.04%±21.01%,P < 0.05 and control group(76.33%±7.82%,P < 0.01,and in other diseases group than in control group(P < 0.05.Correlation analysis indicated that a negative correlation existed between the expression rate of HLA-DR/CD14 and serum CRP level in acute and severe group(r=-0.704,P < 0.01.Dynamic observation of 15 patients in acute and severe group showed:the expression rate of HLA-DR/CD14 decreased continuously without amelioration in 6 died patients till their death;while was improved gradually to normal level with symptom improving in other 9 survival patients till their recovery.Conclusion The expression rate of HLA-DR/CD14 on peripheral blood mononuclear cells is closely related to the severity of infection and disease,and may be used as an immune parameter to estimate the clinical severity and prognosis of acute and severe diseases.

  11. HLA-DR expression on monocytes is decreased in polytraumatized patients.

    Science.gov (United States)

    Vester, Helen; Dargatz, P; Huber-Wagner, S; Biberthaler, P; van Griensven, M

    2015-10-16

    Sepsis, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) remain the most frequent causes of complications and death in severely injured patients. A main reason for the development of these syndromes is a post-traumatic dysregulation of the immune system. Several studies in intensive care unit (ICU) patients could detect a pivotal role of HLA-DR expression on monocytes. So far, its importance for development of SIRS, sepsis or MODS in the severely injured patient is not clear. Therefore, we have analysed HLA-DR expression on monocytes from severely injured patients (ISS > 16) during the post-traumatic course, which was on the day of trauma, as well as on days 3, 7 and 14 post trauma. Clinical data were analysed and the HLA-DR expression levels of patients who developed post-traumatic sepsis, SIRS or MODS were compared to those with a more favourable outcome. Young and healthy volunteers as well as patients undergoing prosthetic hip replacement after trauma were enrolled as control groups. HLA-DR molecules on monocytes were marked with PE-conjugated antibodies and the mean fluorescence intensity (MFI) was analysed via flow cytometry. 24 severely injured patients (mean age 34 ± 2.7 years) mainly after high energy motor vehicle accidents as well as 8 controls (total hip replacement) and 9 healthy volunteers (mean age 26.2 ± 1.2 years) were enrolled. A total of eight patients suffered from sepsis (33.3 %) (six males, two females) and 17 patients suffered from SIRS (70.9 %) (10 males, 7 females). MODS was present in five patients (20.8 %), three male and two female patients. In four of these five patients the MODS developed subsequent to sepsis. HLA-DR expression significantly decreased after trauma and slowly returned to normal after 14 days, irrespective of the complications developed. In conclusion, post-traumatic HLA-DR expression on monocytes is significantly reduced after multiple trauma and it is back to

  12. Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

    Science.gov (United States)

    2010-01-01

    Introduction Decreased expression of human leukocyte antigen class II (HLA-DR) on monocytes is a hallmark of altered immune status in patients with a systemic inflammatory response syndrome (SIRS). So far, the analyses were mainly performed without taking into account monocytes subpopulations. Methods We studied this modification on CD14HIGH and CD14LOW monocytes of 20 SIRS patients undergoing abdominal aortic surgery (AAS), 20 patients undergoing carotid artery surgery (CAS), and 9 healthy controls, and we investigated mediators and intracellular molecules that may be involved in this process. Results HLA-DR on CD14HIGH monocytes started to decrease during surgery, after blood reperfusion, and was further reduced post-surgery. In contrast, HLA-DR expression on CD14LOW cells only decreased after surgery, and to a lesser extent than on CD14HIGH monocytes. Negative correlations were found between the reduction of HLA-DR expression and the change in cortisol levels for both subpopulations, whereas a negative correlation between interleukin-10 (IL-10) levels and HLA-DR modulation was only observed for CD14HIGH cells. In accordance with these ex vivo results, HLA-DR on CD14HIGH and CD14LOW monocytes of healthy donors was reduced following incubation with hydrocortisone, whereas IL-10 only acted on CD14HIGH subpopulation. Furthermore, flow cytometry revealed that the expression of IL-10 receptor was higher on CD14HIGH versus CD14LOW monocytes. In addition, hydrocortisone, and to a lesser extent IL-10, reversed the up-regulation of HLA-DR induced by bacterial products. Finally, membrane-associated RING-CH-1 protein (MARCH1) mRNA, a negative regulator of MHC class II, was up-regulated in monocytes of AAS patients on Day 1 post-surgery, and in those of healthy subjects exposed to hydrocortisone. Conclusions This study reveals that HLA-DR expression is modulated differently on CD14HIGH (classical) versus CD14LOW (inflammatory) monocytes after systemic inflammation. PMID

  13. Deinococcus radiodurans Toxin-Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress.

    Science.gov (United States)

    Li, Tao; Weng, Yulan; Ma, Xiaoqiong; Tian, Bing; Dai, Shang; Jin, Ye; Liu, Mengjia; Li, Jiulong; Yu, Jiangliu; Hua, Yuejin

    2017-01-01

    Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5'ACA3', and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A>G>C. MazEF-dr mediated the death of D. radiodurans cells under sub-lethal dose of stresses. The characteristics of programmed cell death (PCD) including membrane blebbing, loss of membrane integrity and cytoplasm condensation occurred in a fraction of the wild-type population at sub-lethal concentration of the DNA damaging agent mitomycin C (MMC); however, a MazEF-dr mutation relieved the cell death, suggesting that MazEF-dr mediated cell death through its endoribonuclease activity in response to DNA damage stress. The MazEF-dr-mediated cell death of a fraction of the population might serve as a survival strategy for the remaining population of D. radiodurans under DNA damage stress.

  14. Deinococcus radiodurans Toxin–Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress

    Science.gov (United States)

    Li, Tao; Weng, Yulan; Ma, Xiaoqiong; Tian, Bing; Dai, Shang; Jin, Ye; Liu, Mengjia; Li, Jiulong; Yu, Jiangliu; Hua, Yuejin

    2017-01-01

    Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5′ACA3′, and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A>G>C. MazEF-dr mediated the death of D. radiodurans cells under sub-lethal dose of stresses. The characteristics of programmed cell death (PCD) including membrane blebbing, loss of membrane integrity and cytoplasm condensation occurred in a fraction of the wild-type population at sub-lethal concentration of the DNA damaging agent mitomycin C (MMC); however, a MazEF-dr mutation relieved the cell death, suggesting that MazEF-dr mediated cell death through its endoribonuclease activity in response to DNA damage stress. The MazEF-dr-mediated cell death of a fraction of the population might serve as a survival strategy for the remaining population of D. radiodurans under DNA damage stress. PMID:28798741

  15. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  16. MTB-DR-RIF 9G test: Detection and discrimination of tuberculosis and multi-drug resistant tuberculosis strains.

    Science.gov (United States)

    Song, Keum-Soo; Nimse, Satish Balasaheb; Cho, Nam Hoon; Sung, Nackmoon; Kim, Hee-Jin; Yang, Jeongseong; Kim, Taisun

    2015-12-01

    This report describes the evaluation of the novel MTB-DR-RIF 9G test for the accurate detection and discrimination of Mycobacterium tuberculosis (MTB) and rifampicin-resistant M. tuberculosis (MTB-DR-RIF) in the clinical samples. The procedure included the amplification of a nucleotide fragment of the rpoB gene of the MTB and MTB-DR-RIF strains and their hybridization with the immobilized probes. The MTB-DR-RIF 9G test was evaluated for its ability to detect and discriminate MTB and MTB-DR-RIF strains in 113 known clinical samples. The accuracy of the MTB-DR-RIF 9G test was determined by comparing its results with sequencing analysis and drug susceptibility testing. The sensitivity and specificity of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 95.4% (89.5-98.5) and 100% (69.2-100), respectively. The positive predictive value and negative predictive value of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 100% (85.0-95.9) and 66.7% (38.4-88.18), respectively. Sequencing analysis of all samples indicated that the mutations present in the regions identified with the MTB-DR-RIF 9G assay can be detected accurately. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Deinococcus radiodurans Toxin–Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress

    Directory of Open Access Journals (Sweden)

    Tao Li

    2017-07-01

    Full Text Available Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5′ACA3′, and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A>G>C. MazEF-dr mediated the death of D. radiodurans cells under sub-lethal dose of stresses. The characteristics of programmed cell death (PCD including membrane blebbing, loss of membrane integrity and cytoplasm condensation occurred in a fraction of the wild-type population at sub-lethal concentration of the DNA damaging agent mitomycin C (MMC; however, a MazEF-dr mutation relieved the cell death, suggesting that MazEF-dr mediated cell death through its endoribonuclease activity in response to DNA damage stress. The MazEF-dr-mediated cell death of a fraction of the population might serve as a survival strategy for the remaining population of D. radiodurans under DNA damage stress.

  18. Human leukocyte antigen DR surface expression on CD14+ monocytes during adverse events after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Döring, Michaela; Rohrer, Karin Melanie; Erbacher, Annika; Gieseke, Friederike; Schwarze, Carl-Philipp; Bader, Peter; Handgretinger, Rupert; Hofbeck, Michael; Kerst, Gunter

    2015-02-01

    The human leukocyte antigen DR surface expression on CD14+ monocytes reflects the degree to which these cells have been activated. Given the central role monocytes and macrophages play in the immune system, a decreased human leukocyte antigen DR expression on CD14+ monocytes results in a hallmark of altered immune status during systemic inflammatory response syndrome. We hypothesize that human leukocyte antigen DR expression might be similarly altered after hematopoietic stem cell transplantation and during post-transplant complications. Using flow cytometry, this study investigates the human leukocyte antigen DR surface expression of CD14+ monocytes in 30 pediatric and young adult patients up to 1 year after hematopoietic stem cell transplantation. Normal values were derived from a control group of healthy children, adolescents, and young adults. Human leukocyte antigen DR expression decreased significantly prior and during bacterial infection or sepsis. By contrast, human leukocyte antigen DR expression levels were elevated before and at the time of viremia. Human leukocyte antigen DR expression was also elevated during acute graft-versus-host disease. In contrast, the expression was reduced when patients had hepatic veno-occlusive disease. A significant decrease of human leukocyte antigen DR expression was associated with a relapse of the underlying disease and before death. Human leukocyte antigen DR expression on CD14+ monocytes appears to be a promising parameter that might allow identification of patients at risk after hematopoietic stem cell transplantation.

  19. From the "Art of cutting the umbilical cord" by Dr. J.B. Lalangue to the "Midwifery" by Prof.Dr. A. Lobmayer and Prof.Dr. F.Durst.

    Science.gov (United States)

    Maksimovic, Jovan; Maksimovic, Marko

    2014-01-01

    A short survey of midwifery and obstetrics development in the northwest part of Croatia is presented in this paper, from J.B. Lalangue's coming to VaraŽdin, through the founding and work of Midwifery School and National Maternity in Zagreb to the persons without whom this would not be possible or it would be quite different. Lalangue, being an expert on obstetrics, noticed in a very short period of time, all misfortune caused by incompetent work of then's midwives, so he published the book "Brevis institutio de re obstetritia illiti kratek navuk od mestrie pupkorezne⃛", and started first midwifery courses for peasant women. Focus of this paper is on Prof. Dr Antun Lobmayer textbook analyses, and he was the first professor of midwifery, and the director of the "Royal Midwifery School" and the "National Maternity" in Zagreb. Textbooks for midwives named "Midwifery- Learning Book for Midwives', had six editions over 50 years and they represent the basis of Croatian midwifery textbook literature. Prof. Dr Franjo Durst, the assistant and successor of Prof. Lobmayer completed and partially revised the last two editions.Besides the biographies of the "rdquor;Midwifery School" professors, an analyssis and critical review on the mentioned textbooks is given from today' s medicine point of view.

  20. Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen or tumour derived synthetic peptides

    Directory of Open Access Journals (Sweden)

    Protti Maria

    2005-12-01

    Full Text Available Abstract Background MHC class I-peptide tetramers are currently utilised to characterize CD8+ T cell responses at single cell level. The generation and use of MHC class II tetramers to study antigen-specific CD4+ T cells appears less straightforward. Most MHC class II tetramers are produced with a homogeneously built-in peptide, reducing greatly their flexibility of use. We attempted the generation of "empty" functional HLA-DR*1101 tetramers, receptive for loading with synthetic peptides by incubation. No such reagent is in fact available for this HLA-DR allele, one of the most frequent in the Caucasian population. Results We compared soluble MHC class II-immunoglobulin fusion proteins (HLA-DR*1101-Ig with soluble MHC class II protein fused with an optimised Bir site for enzymatic biotynilation (HLA-DR*1101-Bir, both produced in insect cells. The molecules were multimerised by binding fluorochrome-protein A or fluorochrome-streptavidin, respectively. We find that HLA-DR*1101-Bir molecules are superior to the HLA-DR*1101-Ig ones both in biochemical and functional terms. HLA-DR*1101-Bir molecules can be pulsed with at least three different promiscuous peptide epitopes, derived from Tetanus Toxoid, influenza HA and the tumour associated antigen MAGE-3 respectively, to stain specific CD4+ T cells. Both staining temperature and activation state of CD4+ T cells are critical for the binding of peptide-pulsed HLA-DR*1101-Bir to the cognate TCR. Conclusion It is therefore possible to generate a soluble recombinant HLA-DR*1101 backbone that is receptive for loading with different peptides to stain specific CD4+ T cells. As shown for other HLA-DR alleles, we confirm that not all the strategies to produce soluble HLA-DR*1101 multimers are equivalent.

  1. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    Science.gov (United States)

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  2. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  3. Developmental patterns of DR6 in normal human hippocampus and in Down syndrome

    NARCIS (Netherlands)

    Iyer, A.; van Scheppingen, J.; Anink, J.; Milenkovic, I.; Kovács, G.G.; Aronica, E.

    2013-01-01

    Background Death receptor 6 (DR6) is highly expressed in the human brain: it has been shown to induce axon pruning and neuron death via distinct caspases and to mediate axonal degeneration through binding to N-terminal β amyloid precursor protein (N-APP). Methods We investigated the expression of

  4. Hospital reform and staff morale in South Africa: a case study of Dr ...

    African Journals Online (AJOL)

    2012-02-16

    Feb 16, 2012 ... Original Research: Hospital reform and staff morale in South Africa: a case study of Dr Yusuf Dadoo Hospital. 180. Vol 55 No 2. S Afr Fam ... Design: This study was a cross-sectional descriptive survey. Settings and subjects: ..... lack of team work (up to 100% agreement), not being valued as a person (up to ...

  5. *Engr (Dr.) Egbuniwe is on the staff of Civil Engineering of the ...

    African Journals Online (AJOL)

    Dr Obe

    *Engr (Dr.) Egbuniwe is on the staff of Civil Engineering of the University of Nigeria, Nsukka. VARIATIONS IN THE STATISTICAL MEASURES OF MEAN RAINFALL. By. NNAMDI EGBUNIWE*. ABSTRACT. Rainfall records are required for planning and development of water resources projects. Long term averages of rainfall.

  6. In memorium Dr. Agatha Gijzen (1904-1995), eminent museum historian and zoo biologist

    NARCIS (Netherlands)

    Bruggen, van A.C.

    1996-01-01

    Dr Agatha Gijzen (Rotterdam *9 October 1904, Merksem/Belgium †19 February 1995) was a remarkable zoologist in more than one respect. Although her professional career, spanning more than three and a half decades, was largely spent as a staff zoologist in the service of the famous Antwerp/

  7. Proteomic insights into the functional basis for the response regulator DrRRA of Deinococcus radiodurans.

    Science.gov (United States)

    Wang, Liangyan; Hu, Jing; Liu, Mengjia; Yang, Su; Zhao, Ye; Cheng, Kaiying; Xu, Guangzhi; Li, Mingfeng; Tian, Bing; Hua, Yuejin

    2016-05-01

    Purpose To investigate the function basis of the recently discovered response regulator, drRRA (DNA damage response regulator A) in Deinococcus radiodurans, we compared the proteomic profile of the radiation-sensitive drRRA mutant with that of wild-type strain under both non-stress and gamma radiation treatment. Materials and methods Total proteins of D. radiodurans cells were subjected to two-dimension electrophoresis. Protein spots in 2-Dimension gels were silver stained and scanned. Spots that changed significantly in expression levels were selected for mass spectrometry analysis. Seven genes encoding representative proteins were knocked out for stress resistance analysis. Results A total of 52 proteins displayed significant expression level changes at least 1.5-fold in the mutant relative to wild-type strain under non-stress conditions, with 31 repressed and 21 induced proteins, which might affect the cell response of D. radiodurans to gamma radiation. The proteins were distributed into functional groups including stress response, metabolism, and function unknown. Disruptions of several altered proteins including DRA0259 (Catalase E) and DR1538 (Osmotically inducible protein C), reduced the antioxidant activity of D. radiodurans. Conclusion Combined with our previous result of transcriptional profile, we further confirmed that inactivation of DrRRA affects the expression of various stress response systems.

  8. Current Issues in Teacher Education: An Interview with Dr. Linda Darling-Hammond

    Science.gov (United States)

    Martin, Linda E.; Mulvihill, Thalia M.

    2017-01-01

    Dr. Linda Darling-Hammond is the Charles E. Ducommun Professor of Education Emeritus at the Stanford Graduate School of Education at Stanford University. She is former president of the American Educational Research Association (AERA) and member of the National Academy of Education and the American Academy of Arts and Sciences. She also served as a…

  9. Correlation of MMP-9, GA, HbA1c, and adipokines levels with DR

    Directory of Open Access Journals (Sweden)

    Cheng Qian

    2017-12-01

    Full Text Available AIM: To investigate the correlation of matrix metalloproteinase -9(MMP-9, glycated albumin(GA, glycosylated hemoglobin(HbA1cand adipokines(including visfatin, resistin and leptinwith diabetic retinopathy(DR. METHODS: From March 2015 to March 2017, 74 patients with DR were treated in our hospital, including 40 patients(80 eyeswith non proliferative diabetic retinopathy(NPDRand 34 patients(68 eyeswith proliferative diabetic retinopathy(PDR, and diabetes mellitus 40 patients(80 eyeswith non DR(NDRand 40 healthy volunteers(80 eyeswere selected as controls, the levels of MMP-9, GA, HbA1c, visfatin, resistin and leptin in each group were detected. RESULTS: PDR group visfatin was 4.41±0.82ng/mL, was significantly lower than the NPDR group, NDR group and control group(PPPPrs=0.523, 0.461 and 0.414, Prs=-0.433, Prs=0.401 and 0.460, PCONCLUSION: MMP-9, GA, HbA1c, and adipokines may play a role in the development and progression of DR, in which MMP-9 is associated with adipokines, both are not significantly related to the levels of GA and HbA1c.

  10. Gaming Sea-based Multinational HA/DR Operations at PACOM Amphibious Leaders Symposium 2016

    Science.gov (United States)

    2016-11-01

    communications among all involved parties and host-nation leadership of disaster relief operations. During future multinational HA/DR operations, PALS...Humanitarian Response Coordination Center (HRCC) in Changi, Singapore, would be one way to do this. Another option would be to incorporate the lessons ...26  Malaysia

  11. Professor Dr. Hendrik Engel (20 February 1898 – 12 April 1981)

    NARCIS (Netherlands)

    NN,

    1982-01-01

    It is with deep regret that the editors of BIJDRAGEN TOT DE DIERKUNDE and the staff of the Zoölogisch Museum, Amsterdam, have to announce the sudden decease of Prof. Dr. Hendrik Engel in his home town Almen (province of Gelderland) at the age of 83 years. Until his retirement in 1968, at the age of

  12. Report on Sabbatical activities - Dr. Ronnie Shepherd - 05/25/2014 to 08/21/2014

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, Ronnie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-10-09

    The sabbatical performed by Dr. Ronnie Shepherd from 05/25/2014 to 08/21/2014 had two central goals: 1) write three proposals for future collaborative experiments at Ecole Polytechnique (and possibly LLNL) 2) if laser time was granted (based on the proposal), perform a preliminary experiment in preparation for the campaign of laser time based on proposal submission.

  13. Dr Math moves to C³TO: Chatter call center/tutoring online

    CSIR Research Space (South Africa)

    Butgereit, L

    2010-01-01

    Full Text Available Dr Math is a mobile tutoring system which has been running in South Africa for three years. It links primary and secondary school pupils to tutors in mathematics. The pupils use the popular Mxit chat client on their cell phones. The tutors use full...

  14. prognostic significance of hla-dr antigen in dysplasia, carcinoma in ...

    African Journals Online (AJOL)

    2003-11-11

    Nov 11, 2003 ... The immune attract mechanism by low HLA-DR signalling seems to be of minor importance in the malignant and metastatic potential of the gallbladder, epithelial tumours. INTRODUCTION. The major histocompatibility complex is a series of genes that participate in the regulation of the immune response.

  15. 30 calibabor Vertical Gun Range in horizontal loading position. Dr. William Quaide and Donald Gault

    Science.gov (United States)

    1965-01-01

    30 calibabor Vertical Gun Range in horizontal loading position. Dr. William Quaide and Donald Gault of Ames planetology branch used this gun range to study the formation of impact craters on the Moon. N-204A Verticle Gun is used to simulate the physics and mechanics of planetaryimpact cratering phenomena.

  16. Riemen om de kin! : Biografie van mr.dr. Gerrit Jan van Heuven Goedhart

    NARCIS (Netherlands)

    Corduwener, Jeroen

    2011-01-01

    Dr. Gerrit Jan van Heuven Goedhart struggled all his life: against international disinterest to refugees, colonial conservatism in the Dutch East Indies, the German occupiers of The Netherlands, Dutch sentiments of revenge as a result of the Second World War. Furthermore, he struggled against

  17. Post-Disaster Image Processing for Damage Analysis Using GENESI-DR, WPS and Grid Computing

    Directory of Open Access Journals (Sweden)

    Marco Pappalardo

    2011-06-01

    Full Text Available The goal of the two year Ground European Network for Earth Science Interoperations-Digital Repositories (GENESI-DR project was to build an open and seamless access service to Earth science digital repositories for European and world-wide science users. In order to showcase GENESI-DR, one of the developed technology demonstrators focused on fast search, discovery, and access to remotely sensed imagery in the context of post-disaster building damage assessment. This paper describes the scenario and implementation details of the technology demonstrator, which was developed to support post-disaster damage assessment analyst activities. Once a disaster alert has been issued, response time is critical to providing relevant damage information to analysts and/or stakeholders. The presented technology demonstrator validates the GENESI-DR project data search, discovery and security infrastructure and integrates the rapid urban area mapping and the near real-time orthorectification web processing services to support a post-disaster damage needs assessment analysis scenario. It also demonstrates how the GENESI-DR SOA can be linked to web processing services that access grid computing resources for fast image processing and use secure communication to ensure confidentiality of information.

  18. Neue Phoriden aus Belgisch-Kongo, gesammelt von Dr. Jos. Bequaert

    NARCIS (Netherlands)

    Schmitz, H.

    1916-01-01

    Durch die Güte des Herrn Dr. Jos. Bequaert konnte ich einige Phoriden untersuchen, die dieser eifrige Entomologe während seines letzten Aufenthalts am Kongo und im Ruwenzori-Gebirge gesammelt hat. Es lagen im ganzen 5 Arten vor, darunter zwei neue, die im folgenden beschrieben werden. Von den drei

  19. Dr. Mary McLeod Bethune: A Life Devoted to Service

    Science.gov (United States)

    Long, Kim Cliett

    2011-01-01

    The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

  20. Strong CH+ J=1-0 emission and absorption in DR21

    NARCIS (Netherlands)

    Falgarone, E.; Ossenkopf, V.; Gerin, M.; Lesaffre, P.; Godard, B.; Pearson, J.; Cabrit, S.; Joblin, Ch; Benz, A. O.; Boulanger, F.; Fuente, A.; Güsten, R.; Harris, A.; Klein, T.; Kramer, C.; Lord, S.; Martin, P.; Martin-Pintado, J.; Neufeld, D.; Phillips, T. G.; Röllig, M.; Simon, R.; Stutzki, J.; van der Tak, F.; Teyssier, D.; Yorke, H.; Erickson, N.; Fich, M.; Jellema, W.; Marston, A.; Risacher, C.; Salez, M.; Schmülling, F.

    We report the first detection of the ground-state rotational transition of the methylidyne cation CH+ towards the massive star-forming region DR 21 with the HIFI instrument onboard the Herschel satellite. The line profile exhibits a broad emission line, in addition to two deep and broad absorption