WorldWideScience

Sample records for survey 1-12 percent

  1. Five Percent Post Survey Check Of National Family Health Survey (NFHS In ORISSA

    Directory of Open Access Journals (Sweden)

    Kumar Benera Sudhir

    1999-01-01

    Full Text Available Research questions: How well a post survey sample check of NFHS correlates with the findings of NFHS? Objective: Post survey check of National Family Health Survey carried out in 1992-93. Study design: Multistage sampling method with 5 percent sample of original NFHS sample. Setting: Study covered 5 percent sample of original NFHS sample. Subjects: Five percent household sample (1093 members of original NFHS sample was studied and compared with NFHS data. Method: Information from five percent house-holds of NFHS in which either there likely to be no change was likely to be only in one direction such as age group, sex-ratio, literacy, family planning knowledge and adoption etc. were collected in a predesigned questionnaire and compared with NFHS data. Results: The demographic characteristics were similar to those of NFHS. TFR and number of children ever borne were also found to be same. The awareness of FP methods and its uses were within acceptable margin of error. Thus on comparison of data of post survey check and NFHS sample error was within acceptable margin.

  2. A 1.2 meter balloon-borne telescope for a submillimeter wave sky survey

    Science.gov (United States)

    Silverberg, R. F.; Hauser, M. G.; Mather, J. C.; Gezari, D. Y.; Kelsall, T.; Cheung, L. H.

    1979-01-01

    A balloon-borne, 1.2 meter Cassegrain telescope designed for diffraction-limited imagery at 100 microns is being developed for a survey of the Galactic plane at submillimeter wavelengths. The telescope pointing system is servocontrolled using a gyroscope for the primary stabilization reference. Extensive use is made of microprocessors for flight sequencing, pointing control and stabilization, and telemetry formatting. A description of the telescope, helium-cooled detectors, and the orientation subsystems are presented together with a brief discussion of the proposed astronomical observations.

  3. JPCam: Development of a 1.2 Gpixel Camera for the J-PAS Survey

    Science.gov (United States)

    Marín-Franch, A.; Taylor, K.; Santoro, F. G.; Laporte, R.; Cepa, J.; Lasso-Cabrera, N.; Yanes-Díaz, A.; Cenarro, A. J.; Cristobal-Hornillos, D.; Ederoclite, A.; Moles, M.; Varela, J.; Vázquez-Ramió, H.; Antón, J. L.; Bello, R.; Civera, T.; Castillo, J.,; Chueca, S.; Guillén-Civera, L.; Hernández-Fuertes, J.; Igual, R.; Íniguez, C.; López-Alegre, G.; López-Sainz, A.; Nevot, C.; Milla, R.; Muniesa, D.; Pe, A.; Rueda-Teruel, R.; Rueda-Teruel, F.; Sánchez, J.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Mendes de Oliveira, C.; Sodré, L.

    2017-03-01

    To carry out J-PAS survey, the JST/T250 telescope at the Observatorio Astrofósico de Javalambre (OAJ) is equipped with JPCam, a panoramic camera designed to exploit survey capabilities of the telescope. JPCam is a direct imaging instrument designed to work in a fast convergent beam at the telescope’s Cassegrain focus. It is based on state-of-the-art, high efficiency, low noise 9.2k-by-9.2k, 10μm pixel CCDs specially developed by e2v for JPCam. The instrument is equipped with a 1.2Gpixel mosaic of 14 CCDs providing a useful FoV of 4.7 deg2 (67% focal plane coverage) with a plate scale of 0.2267 arcsec/pix. Moreover, JPCam includes 12 auxiliary detectors for auto-guiding and wave front sensing purposes. JPCam is completed with an innovative set of 59 optical filters specifically designed to perform accurate BAO measurements, main science driver of J-PAS.

  4. JPCam: A 1.2Gpixel camera for the J-PAS survey

    CERN Document Server

    Taylor, K; Laporte, R; Santoro, F G; Marrara, L; Cepa, J; Cenarro, A J; Chueca, S; Cristobal-Hornillos, D; Ederoclite, A; Gruel, N; Moles, M; Rueda, F; Rueda, S; Varela, J; Yanes, A; Benitez, N; Dupke, R; Fernandez-Soto, A; Jorden, P; Lousberg, G; Benito, A Molino; Palmer, I; de Oliveira, C Mendes; Sodre, L

    2013-01-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k 10microm-pixel 16-channel detectors, to be deployed on a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofisico de Javalambre) in Aragon, Spain. The camera is designed to perform a Baryon Acoustic Oscillations (BAO) survey of the northern sky. The J-PAS survey strategy will use 54 relatively narrow-band (~13.8nm) filters equi-spaced between 370 and 920nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over ~8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v under contract to J-PAS while the mechanical structure, housing the shutter and filter assembly, is being designed and constructed by a Brazilian consortium led by INPE (Instituto Nacional de Pesquisas Espaciais). Four sets of 14 filters are placed in the ambient environment, just above the dewar window but directly in line with the detectors, leading to a mosaic having ~1...

  5. Jpcam: a 1.2 Gpixel Camera for the J-Pas Survey

    Science.gov (United States)

    Taylor, K.; Marín-Franch, A.; Laporte, R.; Santoro, F. G.; Marrara, L.; Cepa, J.; Cenarro, A. J.; Chueca, S.; Cristobal-Hornillos, D.; Ederoclite, A.; Gruel, N.; Moles, M.; Rueda, F.; Rueda, S.; Varela, J.; Yanes, A.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Jorden, P.; Lousberg, G.; Molino Benito, A.; Palmer, I.; Mendes de Oliveira, C.; Sodré, L.

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k 10 μm-pixel 16-channel detectors, to be deployed on a dedicated 2.55 m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Aragon, Spain. The camera is designed to perform a Baryon Acoustic Oscillations (BAO) survey of the northern sky. The J-PAS survey strategy will use 54 relatively narrow-band ( 13.8 nm) filters equi-spaced between 370 and 920 nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics, is being supplied by e2v under contract to J-PAS while the mechanical structure, housing the shutter and filter assembly, is being designed and constructed by a Brazilian consortium led by INPE (Instituto Nacional de Pesquisas Espaciais). The cryostat is bridged to the telescope via a hexapod actuator system to maintain image quality across the field. Four sets of 14 filters are placed in the ambient environment, just above the dewar window but directly in line with the detectors, leading to a mosaic having 10 mm gaps between each CCD. The massive 500 mm aperture shutter is expected to be supplied by the Bonn-Shutter UG. We will present an overview of JPCam, from the filter configuration through to the CCD mosaic camera. A brief outline of the main J-PAS science projects will be included.

  6. JPCam: Status of the 1.2Gpixel camera for the J-PAS survey.

    Science.gov (United States)

    Taylor, Keith; Marín-Franch, Antonio; Santoro, Fernando; Mendes de Oliveira, Claudia; Dupke, Renato

    2015-08-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k, 10 micron pixel detectors, to be deployed on the JST/T250, a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Teruel, Spain. The camera is designed to perform the J-PAS, a BAO survey of the northern sky. The J-PAS survey strategy will use 59 filters, 56 relatively narrow-band (14.5nm) filters equi-spaced between 350 and 1000nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v. Each science detector is read from 16 ports simultaneously, allowing read times of 14s with a typical read noise of 5e- (rms). The JPCam focal plane will be complemented with 4 autoguiding and 8 wavefront sensing CCDs. Image quality over the whole CCD mosaic will be maintained by applying the required, close loop, focus, tilt and rotation adjustments to the focal plane through the JPCam hexapod actuator system, manufactured by NTE-Sener. The filter unit has been designed to admit 5 filter trays, each mounting 14 filters corresponding to the 14 CCDs of the mosaic. Each CCD will view only its corresponding filter avoiding optical cross-talk from their neighbors. With this configuration, JPCam will cover 4.7 square degrees with a plate scale of 0.2267 arcsec/pix and will allow all the J-PAS filters to be permanently installed on the camera. The massive 525mm aperture shutter is supplied by Bonn-Shutter UG.

  7. Genus Statistics of the Virgo N-body simulations and the 1.2-Jy Redshift Survey

    CERN Document Server

    Springel, V; Colberg, J M; Couchman, H M P; Efstathiou, G P; Frenk, C S; Jenkins, A R; Pearce, F R; Nelson, A H; Peacock, J A; Thomas, P A

    1997-01-01

    We study the topology of the Virgo N-body simulations and compare it to the 1.2-Jy redshift survey of IRAS galaxies by means of the genus statistic. Four high-resolution simulations of variants of the CDM cosmology are considered: a flat standard model (SCDM), a variant of it with more large-scale power (tCDM), and two low density universes, one open (OCDM) and one flat (LCDM). The fully sampled N-body simulations are examined down to strongly nonlinear scales, both with spatially fixed smoothing, and with an adaptive smoothing technique. While the tCDM, LCDM, and OCDM simulations have very similar genus statistics in the regime accessible to fixed smoothing, they can be separated with adaptive smoothing at small mass scales. In order to compare the N-body models with the 1.2-Jy survey, we extract large ensembles of mock catalogues from the simulations. These mock surveys are used to test for systematic effects in the genus analysis and to establish the distribution of errors of the genus curve. We find that ...

  8. The VVDS-SWIRE-GALEX-CFHTLS surveys: Physical properties of galaxies at z below 1.2 from photometric data

    CERN Document Server

    Walcher, C J; Vergani, D; Arnouts, S; Buat, V; Charlot, S; Tresse, L; Le Fèvre, O; Bolzonella, M; Brinchmann, J; Pozzetti, L; Zamorani, G; Bottini, D; Garilli, B; Le Brun, V; MacCagni, D; Milliard, B; Scaramella, R; Scodeggio, M; Vettolani, G; Zanichelli, A; Adami, C; Bardelli, S; Cappi, A; Ciliegi, P; Contini, T; Franzetti, P; Foucaud, S; Gavignaud, I; Guzzo, L; Ilbert, O; Iovino, A; McCracken, H J; Marano, B; Marinoni, C; Mazure, A; Meneux, B; Merighi, R; Paltani, S; Pellò, R; Pollo, A; Radovich, M; Zucca, E; Lonsdale, C; Martin, D C

    2008-01-01

    We intend to show that it is possible to derive the physical parameters of galaxies from their broad-band spectral energy distribution out to a redshift of 1.2. This method has the potential to yield the physical parameters of all galaxies in a single field in a homogeneous way. We use an extensive dataset, assembled in the context of the VVDS survey, which reaches from the UV to the IR and covers a sample of 84073 galaxies over an area of 0.89 deg$^2$. We also use a library of 100000 model galaxies with a large variety of star formation histories (in particular including late bursts of star formation). We find that we can determine the physical parameters stellar mass, age and star formation rate with good confidence. We validate the star formation rate determinations in particular by comparing it to a sample of spectroscopically observed galaxies with an emission line measurement. We use our sample to build the number density function of galaxies as a function of stellar mass, specific star formation rate a...

  9. Prevalence of HTLV-1/2 infections in Spain: A cross-sectional hospital-based survey.

    Science.gov (United States)

    Treviño, Ana; García, Juan; de Mendoza, Carmen; Benito, Rafael; Aguilera, Antonio; Ortíz de Lejarazu, Raul; Ramos, José M; Trigo, Matilde; Eirós, Jose M; Rodríguez-Iglesias, Manuel; Torres, Alvaro; Calderón, Enrique; Hernandez, Araceli; Gomez, Cesar; Marcaida, Goizane; Soriano, Vincent

    2010-08-01

    The presence of antibodies to human T-lymphotropic virus (HTLV) types 1 and 2 was examined in 5742 sera belonging to consecutive adult outpatients attended during June 2008 at 13 different hospitals across Spain. Overall, 58.8% were female. Foreigners represented 8% of the study population. Seven individuals were seropositive for HTLV-2 (overall prevalence 0.12%). No cases of HTLV-1 infection were found. All HTLV-2(+) subjects were Spanish natives, of whom six were coinfected with HIV-1 and five with hepatitis C virus (HCV). Moreover, all but one of the HTLV-2(+) subjects had been intravenous drug users. In summary, this cross-sectional survey suggests that the rate of HTLV infection in Spain is low, and is mostly represented by HTLV-2. Infected individuals are generally Spanish natives with a prior history of intravenous drug use and are coinfected with HIV-1 and/or HCV.

  10. ALMA spectroscopic survey in the Hubble Ultra Deep Field: Continuum number counts, resolved 1.2-mm extragalactic background, and properties of the faintest dusty star forming galaxies

    CERN Document Server

    Aravena, Manuel; Walter, Fabian; Da Cunha, Elisabete; Bauer, Franz E; Carilli, Christopher; Daddi, Emanuele; Elbaz, David; Ivison, R J; Riechers, Dominik; Smail, Ian R; Swinbank, Mark; Weiss, Axel; Anguita, Timo; Assef, Roberto J; Bell, Eric; Bertoldi, Frank; Bacon, Roland; Bouwens, Rychard; Cortes, Paulo; Cox, Pierre; Gónzalez-López, Jorge; Hodge, Jacqueline; Ibar, Eduardo; Inami, Hanae; Infante, Leopoldo; Karim, Alexander; Fèvre, Olivier Le; Magnelli, Benjamin; Ota, Kauzuaki; Popping, Gergö; Sheth, Kartik; van der Werf, Paul; Wagg, Jeffrey

    2016-01-01

    We present an analysis of a deep (1$\\sigma$=13 $\\mu$Jy) cosmological 1.2-mm continuum map based on ASPECS, the ALMA Spectroscopic Survey in the Hubble Ultra Deep Field. In the 1 arcmin$^2$ covered by ASPECS we detect nine sources at $>3.5\\sigma$ significance at 1.2-mm. Our ALMA--selected sample has a median redshift of $z=1.6\\pm0.4$, with only one galaxy detected at z$>$2 within the survey area. This value is significantly lower than that found in millimeter samples selected at a higher flux density cut-off and similar frequencies. Most galaxies have specific star formation rates similar to that of main sequence galaxies at the same epoch, and we find median values of stellar mass and star formation rates of $4.0\\times10^{10}\\ M_\\odot$ and $\\sim40~M_\\odot$ yr$^{-1}$, respectively. Using the dust emission as a tracer for the ISM mass, we derive depletion times that are typically longer than 300 Myr, and we find molecular gas fractions ranging from $\\sim$0.1 to 1.0. As noted by previous studies, these values ar...

  11. A deep/wide 1-2 GHz snapshot survey of SDSS Stripe 82 using the Karl G. Jansky Very Large Array in a compact hybrid configuration

    Science.gov (United States)

    Heywood, I.; Jarvis, M. J.; Baker, A. J.; Bannister, K. W.; Carvalho, C. S.; Hardcastle, M.; Hilton, M.; Moodley, K.; Smirnov, O. M.; Smith, D. J. B.; White, S. V.; Wollack, E. J.

    2016-08-01

    We have used the Karl G. Jansky Very Large Array to image ˜100 deg2 of SDSS Stripe 82 at 1-2 GHz. The survey consists of 1026 snapshot observations of 2.5 min duration, using the hybrid CnB configuration. The survey has good sensitivity to diffuse, low surface brightness structures and extended radio emission, making it highly synergistic with existing 1.4 GHz radio observations of the region. The principal data products are continuum images, with 16 × 10 arcsec resolution, and a catalogue containing 11 782 point and Gaussian components resulting from fits to the thresholded Stokes-I brightness distribution, forming approximately 8948 unique radio sources. The typical effective 1σ noise level is 88 μJy beam-1. Spectral index estimates are included, as derived from the 1 GHz of instantaneous bandwidth. Astrometric and photometric accuracy are in excellent agreement with existing narrowband observations. A large-scale simulation is used to investigate clean bias, which we extend into the spectral domain. Clean bias remains an issue for snapshot surveys with the VLA, affecting our total intensity measurements at the ˜1σ level. Statistical spectral index measurements are in good agreement with existing measurements derived from matching separate surveys at two frequencies. At flux densities below ˜35σ the median in-band spectral index measurements begin to exhibit a bias towards flatness that is dependent on both flux density and the intrinsic spectral index. In-band spectral curvature measurements are likely to be unreliable for all but the very brightest components. Image products and catalogues are publicly available via an FTP server.

  12. Spectroscopic Confirmation of Two Massive Red-sequence-selected Galaxy Clusters at Z Approximately Equal to 1.2 in the Sparcs-North Cluster Survey

    Science.gov (United States)

    Muzzin, Adam; Wilson, Gillian; Yee, H.K.C.; Hoekstra, Henk; Gilbank, David; Surace, Jason; Lacy, Mark; Blindert, Kris; Majumdar, Subhabrata; Demarco, Ricardo; Gardner, Jonathan P.; Gladders, Mike; Lonsdale, Carol

    2008-01-01

    The Spitzer Adaptation of the Red-sequence Cluster Survey (SpARCS) is a deep z -band imaging survey covering the Spitzer SWIRE Legacy fields designed to create the first large homogeneously-selected sample of massive clusters at z > 1 using an infrared adaptation of the cluster red-sequence method. We present an overview of the northern component of the survey which has been observed with CFHT/MegaCam and covers 28.3 deg(sup 2). The southern component of the survey was observed with CTIO/MOSAICII, covers 13.6 deg(sup 2), and is summarized in a companion paper by Wilson et al. (2008). We also present spectroscopic confirmation of two rich cluster candidates at z approx. 1.2. Based on Nod-and- Shuffle spectroscopy from GMOS-N on Gemini there are 17 and 28 confirmed cluster members in SpARCS J163435+402151 and SpARCS J163852+403843 which have spectroscopic redshifts of 1.1798 and 1.1963, respectively. The clusters have velocity dispersions of 490 +/- 140 km/s and 650 +/- 160 km/s, respectively which imply masses (M(sub 200)) of (1.0 +/- 0.9) x 10(exp 14) Stellar Mass and (2.4 +/- 1.8) x 10(exp 14) Stellar Mass. Confirmation of these candidates as bonafide massive clusters demonstrates that two-filter imaging is an effective, yet observationally efficient, method for selecting clusters at z > 1.

  13. A deep / wide 1-2 GHz snapshot survey of SDSS Stripe 82 using the Karl G. Jansky Very Large Array in a compact hybrid configuration

    CERN Document Server

    Heywood, I; Baker, A J; Bannister, K W; Carvalho, C S; Hardcastle, M; Hilton, M; Moodley, K; Smirnov, O M; Smith, D J B; White, S V; Wollack, E J

    2016-01-01

    We have used the Karl G. Jansky Very Large Array to image ~100 sq. deg. of SDSS Stripe 82 at 1-2 GHz. The survey consists of 1,026 snapshot observations of 2.5 minutes duration, using the hybrid CnB configuration. The survey has good sensitivity to diffuse, low surface brightness structures and extended radio emission, making it highly synergistic with existing 1.4 GHz radio observations of the region. The principal data products are continuum images, with 16 x 10 arcsecond resolution, and a catalogue containing 11,782 point and Gaussian components resulting from fits to the thresholded Stokes-I brightness distribution, forming approximately 8,948 unique radio sources. The typical effective 1{\\sigma} noise level is 88 {\\mu}Jy / beam. Spectral index estimates are included, as derived from the 1 GHz of instantaneous bandwidth. Astrometric and photometric accuracy are in excellent agreement with existing narrowband observations. A large-scale simulation is used to investigate clean bias, which we extend into the...

  14. MASSIV: Mass Assembly Survey with SINFONI in VVDS. III. Evidence for positive metallicity gradients in z~1.2 star-forming galaxies

    CERN Document Server

    Queyrel, J; Kissler-Patig, M; Epinat, B; Amram, P; Garilli, B; Fevre, O Le; Moultaka, J; Paioro, L; Tasca, L; Tresse, L; Vergani, D; Lopez-Sanjuan, C; Perez-Montero, E

    2011-01-01

    A key open issue for galaxy evolution and formation models is the understanding of the different mechanisms of galaxy assembly at various cosmic epochs. The aim of this study is to derive the global and spatially-resolved metal content in high-redshift galaxies. Using VLT/SINFONI IFU spectroscopy of a first sample of 50 galaxies at z~1.2 in the MASSIV survey, we are able to measure the Ha and [NII]6584 emission lines. Using the N2 ratio as a proxy for oxygen abundance in the interstellar medium, we measure the metallicity of the sample galaxies. We develop a tool to extract spectra in annular regions of these galaxies, leading to a spatially-resolved estimate of the oxygen abundance in each galaxy. We derive a metallicity gradient for 26 galaxies in our sample and discover a significant fraction of galaxies with a "positive" gradient. Using a simple chemical evolution model, we derive infall rates of pristine gas onto the disks. Seven galaxies display a positive gradient at a high confidence level. Four out o...

  15. Galaxies in X-ray Selected Clusters and Groups in Dark Energy Survey Data: Stellar Mass Growth of Bright Central Galaxies Since z~1.2

    CERN Document Server

    Zhang, Y; Mckay, T; Rooney, P; Evrard, A E; Romer, A K; Perfecto, R; Song, J; Desai, S; Mohr, J; Wilcox, H; Bermeo, A; Jeltema, T; Hollowood, D; Bacon, D; Capozzi, D; Collins, C; Das, R; Gerdes, D; Hennig, C; Hilton, M; Hoyle, B; Kay, S; Liddle, A; Mann, R G; Mehrtens, N; Nichol, R C; Papovich, C; Sahlén, M; Soares-Santos, M; Stott, J; Viana, P T; Abbott, T; Abdalla, F B; Banerji, M; Bauer, A H; Benoit-Lévy, A; Bertin, E; Brooks, D; Buckley-Geer, E; Burke, D L; Rosell, A Carnero; Castander, F J; Diehl, H T; Doel, P; Cunha, C E; Eifler, T F; Neto, A Fausti; Fernandez, E; Flaugher, B; Fosalba, P; Frieman, J; Gaztanaga, E; Gruen, D; Gruendl, R A; Honscheid, K; James, D; Kuehn, K; Kuropatkin, N; Lahav, O; Maia, M A G; Makler, M; Marshall, J L; Martini, Paul; Miquel, R; Ogando, R; Plazas, A A; Roodman, A; Rykoff, E S; Sako, M; Sanchez, E; Scarpine, V; Schubnell, M; Sevilla, I; Smith, R C; Sobreira, F; Suchyta, E; Swanson, M E C; Tarle, G; Thaler, J; Tucker, D; Vikram, V; Da Costa, L N

    2015-01-01

    Using the science verification data of the Dark Energy Survey (DES) for a new sample of 106 X-Ray selected clusters and groups, we study the stellar mass growth of Bright Central Galaxies (BCGs) since redshift 1.2. Compared with the expectation in a semi-analytical model applied to the Millennium Simulation, the observed BCGs become under-massive/under-luminous with decreasing redshift. We incorporate the uncertainties associated with cluster mass, redshift, and BCG stellar mass measurements into analysis of a redshift-dependent BCG-cluster mass relation, $m_{*}\\propto(\\frac{M_{200}}{1.5\\times 10^{14}M_{\\odot}})^{0.24\\pm 0.08}(1+z)^{-0.19\\pm0.34}$, and compare the observed relation to the simulation prediction. We estimate the average growth rate since z = 1.0 for BCGs hosted by clusters of $M_{200, z}=10^{13.8}M_{\\odot}$, at $z=1.0$: $m_{*, BCG}$ appears to have grown by $0.13\\pm0.11$ dex, in tension at $\\sim 2.5 \\sigma$ significance level with the 0.4 dex growth rate expected in the simulation. We show that...

  16. Herschel Observations of Extraordinary Sources: Analysis of the HIFI 1.2 THz Wide Spectral Survey toward Orion KL. I. Methods

    NARCIS (Netherlands)

    Crockett, Nathan R.; Bergin, Edwin A.; Neill, Justin L.; Favre, Cécile; Schilke, Peter; Lis, Dariusz C.; Bell, Tom A.; Blake, Geoffrey; Cernicharo, José; Emprechtinger, Martin; Esplugues, Gisela B.; Gupta, Harshal; Kleshcheva, Maria; Lord, Steven; Marcelino, Nuria; McGuire, Brett A.; Pearson, John; Phillips, Thomas G.; Plume, Rene; van der Tak, Floris; Tercero, Belén; Yu, Shanshan

    2014-01-01

    We present a comprehensive analysis of a broadband spectral line survey of the Orion Kleinmann-Low nebula (Orion KL), one of the most chemically rich regions in the Galaxy, using the HIFI instrument on board the Herschel Space Observatory. This survey spans a frequency range from 480 to 1907 GHz at

  17. survey1_2m: Swath bathymetry gridded data (survey 1) collected by the U.S. Geological Survey surrounding Muskeget Channel, MA, October 2010 (Esri grid, UTM Zone 19N, WGS 84, 2-m resolution)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — These data were collected in a collaboration between the Woods Hole Oceanographic Institution and the U.S. Geological Survey (USGS). The primary objective of this...

  18. Herschel Observations of Extra-Ordinary Sources (hexos) : Analysis of the Hifi 1.2 Thz Wide Spectral Survey Toward Orion KL

    NARCIS (Netherlands)

    Crockett, N. R.; Bergin, E. A.; Wang, S.; Blake, G.; Emprechtinger, M.; Lis, D.; Gupta, H.; Pearson, J.; Yu, S.; Bell, T.; Cernicharo, J.; Lord, S.; Plume, R.; Schilke, P.; van der Tak, F.

    2011-01-01

    We present a full spectral survey of the Kleiman-Low nebula within the Orion Molecular Cloud (Orion KL), one of the most chemically rich regions in the galaxy, using the HIFI instrument on board the Herschel Space Observatory. These observations span a frequency range of 490 -- 1240 GHz and 1430 --

  19. Herschel Observations of EXtra-Ordinary Sources (HEXOS): Analysis of the HIFI 1.2 THz Wide Spectral Survey Toward Orion KL

    NARCIS (Netherlands)

    Crockett, N. R.; Bergin, E. A.; Bell, T. A.; Blake, G.; Cernicharo, J.; Emprechtinger, M.; Gupta, H.; Lord, S.; Pearson, J.; Plume, R.; Schilke, P.; van der Tak, F.; Wang, S.; Yu, S.

    2011-01-01

    We present a full spectral survey of the Kleiman-Low nebula within the Orion Molecular Cloud (Orion KL), one of the most chemically rich regions in the galaxy, using the HIFI instrument on board the Herschel Space Observatory. These observations, shown in the figure below, span a frequency range of

  20. Herschel Observations of Extra-Ordinary Sources (hexos): Analysis of the Hifi 1.2 Thz Wide Spectral Survey Toward Orion KL

    NARCIS (Netherlands)

    Crockett, N. R.; Bergin, E. A.; Wang, S.; Blake, G.; Emprechtinger, M.; Lis, D.; Gupta, H.; Pearson, J.; Yu, S.; Bell, T.; Cernicharo, J.; Lord, S.; Plume, R.; Schilke, P.; van der Tak, F.

    2011-01-01

    We present a full spectral survey of the Kleiman-Low nebula within the Orion Molecular Cloud (Orion KL), one of the most chemically rich regions in the galaxy, using the HIFI instrument on board the Herschel Space Observatory. These observations span a frequency range of 490 -- 1240 GHz and 1430 --

  1. Herschel observations of extraordinary sources: Analysis of the HIFI 1.2 THz wide spectral survey toward orion KL. I. method

    Energy Technology Data Exchange (ETDEWEB)

    Crockett, Nathan R.; Bergin, Edwin A.; Neill, Justin L.; Favre, Cécile [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Schilke, Peter [Physikalisches Institut, Universität zu Köln, Zülpicher Str. 77, D-50937 Köln (Germany); Lis, Dariusz C.; Emprechtinger, Martin; Phillips, Thomas G. [Cahill Center for Astronomy and Astrophysics 301-17, California Institute of Technology, Pasadena, CA 91125 (United States); Bell, Tom A.; Cernicharo, José; Esplugues, Gisela B. [Centro de Astrobiología (CSIC/INTA), Laboratiorio de Astrofísica Molecular, Ctra. de Torrejón a Ajalvir, km 4, E-28850 Torrejón de Ardoz, Madrid (Spain); Blake, Geoffrey; Kleshcheva, Maria [Division of Geological and Planetary Sciences, California Institute of Technology, MS 150-21, Pasadena, CA 91125 (United States); Gupta, Harshal; Pearson, John [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Lord, Steven [Infrared Processing and Analysis Center, California Institute of Technology, MS 100-22, Pasadena, CA 91125 (United States); Marcelino, Nuria [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); McGuire, Brett A. [Division of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, CA 91125 (United States); Plume, Rene [Department of Physics and Astronomy, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4 (Canada); Van der Tak, Floris [SRON Netherlands Institute for Space Research, P.O. Box 800, 9700 AV Groningen (Netherlands); and others

    2014-06-01

    We present a comprehensive analysis of a broadband spectral line survey of the Orion Kleinmann-Low nebula (Orion KL), one of the most chemically rich regions in the Galaxy, using the HIFI instrument on board the Herschel Space Observatory. This survey spans a frequency range from 480 to 1907 GHz at a resolution of 1.1 MHz. These observations thus encompass the largest spectral coverage ever obtained toward this high-mass star-forming region in the submillimeter with high spectral resolution and include frequencies >1 THz, where the Earth's atmosphere prevents observations from the ground. In all, we detect emission from 39 molecules (79 isotopologues). Combining this data set with ground-based millimeter spectroscopy obtained with the IRAM 30 m telescope, we model the molecular emission from the millimeter to the far-IR using the XCLASS program, which assumes local thermodynamic equilibrium (LTE). Several molecules are also modeled with the MADEX non-LTE code. Because of the wide frequency coverage, our models are constrained by transitions over an unprecedented range in excitation energy. A reduced χ{sup 2} analysis indicates that models for most species reproduce the observed emission well. In particular, most complex organics are well fit by LTE implying gas densities are high (>10{sup 6} cm{sup –3}) and excitation temperatures and column densities are well constrained. Molecular abundances are computed using H{sub 2} column densities also derived from the HIFI survey. The distribution of rotation temperatures, T {sub rot}, for molecules detected toward the hot core is significantly wider than the compact ridge, plateau, and extended ridge T {sub rot} distributions, indicating the hot core has the most complex thermal structure.

  2. Herschel observations of EXtra-Ordinary Sources: Analysis of the HIFI 1.2 THz Wide Spectral Survey Toward Orion KL I. Methods

    CERN Document Server

    Crockett, Nathan R; Neill, Justin L; Favre, Cécile; Schilke, Peter; Lis, Dariusz C; Bell, Tom A; Blake, Geoffrey; Cernicharo, José; Emprechtinger, Martin; Esplugues, Gisela B; Gupta, Harshal; Kleshcheva, Maria; Lord, Steven; Marcelino, Nuria; McGuire, Brett A; Pearson, John; Phillips, Thomas G; Plume, Rene; van der Tak, Floris; Tercero, Belén; Yu, Shanshan

    2014-01-01

    We present a comprehensive analysis of a broad band spectral line survey of the Orion Kleinmann-Low nebula (Orion KL), one of the most chemically rich regions in the Galaxy, using the HIFI instrument on board the Herschel Space Observatory. This survey spans a frequency range from 480 to 1907 GHz at a resolution of 1.1 MHz. These observations thus encompass the largest spectral coverage ever obtained toward this high-mass star-forming region in the sub-mm with high spectral resolution, and include frequencies $>$ 1 THz where the Earth's atmosphere prevents observations from the ground. In all, we detect emission from 39 molecules (79 isotopologues). Combining this dataset with ground based mm spectroscopy obtained with the IRAM 30 m telescope, we model the molecular emission from the mm to the far-IR using the XCLASS program which assumes local thermodynamic equilibrium (LTE). Several molecules are also modeled with the MADEX non-LTE code. Because of the wide frequency coverage, our models are constrained by ...

  3. A Catalog of Bulge+Disk Decompositions and Updated Photometry for 1.12 Million Galaxies in the Sloan Digital Sky Survey

    CERN Document Server

    Simard, Luc; Patton, David R; Ellison, Sara L; McConnachie, Alan W

    2011-01-01

    We perform two-dimensional, Point-Spread-Function-convolved, bulge+disk decompositions in the $g$ and $r$ bandpasses on a sample of 1,123,718 galaxies from the Legacy area of the Sloan Digital Sky Survey Data Release Seven. Four different decomposition procedures are investigated which make improvements to sky background determinations and object deblending over the standard SDSS procedures that lead to more robust structural parameters and integrated galaxy magnitudes and colors, especially in crowded environments. We use a set of science-based quality assurance metrics namely the disk luminosity-size relation, the galaxy color-magnitude diagram and the galaxy central (fiber) colors to show the robustness of our structural parameters. The best procedure utilizes simultaneous, two-bandpass decompositions. Bulge and disk photometric errors remain below 0.1 mag down to bulge and disk magnitudes of $g \\simeq 19$ and $r \\simeq 18.5$. We also use and compare three different galaxy fitting models: a pure Sersic mod...

  4. Results from Stacking Grism Spectra of Galaxies at 0.6 < z < 1.2 in the Probing Evolution And Reionization Survey (PEARS)

    Science.gov (United States)

    Joshi, Bhavin; Malhotra, Sangeeta; Windhorst, Rogier A.; PEARS Team, FIGS Team

    2016-06-01

    We present results from median stacking of low-resolution grism spectra for ~1700 galaxies at 0.6 ACS G800L grism survey in GOODS-N and GOODS-S. The visible and near-IR coverage of the grism, 6000A to 9500A, provides rest-frame visible wavelength coverage from ~3000A to ~6000A for the redshift range of our sample. We median stack galaxies of similar rest-frame u-r color and stellar mass by selecting them based on their location in our u-r color vs stellar mass diagram. The grism spectra are stacked in bins of 0.3 in u-r color and 0.5 dex in stellar mass over a range of 0.0 < u-r < 3.0 and 7.0 < log(M) [M_sol] < 11.5 with an average of ~30 galaxies per bin. We find that blue cloud galaxies typically show bluer continua, Balmer breaks and also show H-beta and [OIII] emission lines that are blended together due to the low-resolution of the grism. Red sequence galaxies typically show strong 4000A breaks and redder continua and, at lower significance, also the G-band and Mgb absorption features characteristic of late type stars. We also observe that green valley galaxies, which form ~6% of the total sample, typically show weaker 4000A breaks and relatively flatter continua at wavelengths redder than 4000A.

  5. The ALMA Spectroscopic Survey in the Hubble Ultra Deep Field: Continuum Number Counts, Resolved 1.2 mm Extragalactic Background, and Properties of the Faintest Dusty Star-forming Galaxies

    Science.gov (United States)

    Aravena, M.; Decarli, R.; Walter, F.; Da Cunha, E.; Bauer, F. E.; Carilli, C. L.; Daddi, E.; Elbaz, D.; Ivison, R. J.; Riechers, D. A.; Smail, I.; Swinbank, A. M.; Weiss, A.; Anguita, T.; Assef, R. J.; Bell, E.; Bertoldi, F.; Bacon, R.; Bouwens, R.; Cortes, P.; Cox, P.; Gónzalez-López, J.; Hodge, J.; Ibar, E.; Inami, H.; Infante, L.; Karim, A.; Le Le Fèvre, O.; Magnelli, B.; Ota, K.; Popping, G.; Sheth, K.; van der Werf, P.; Wagg, J.

    2016-12-01

    We present an analysis of a deep (1σ = 13 μJy) cosmological 1.2 mm continuum map based on ASPECS, the ALMA Spectroscopic Survey in the Hubble Ultra Deep Field. In the 1 arcmin2 covered by ASPECS we detect nine sources at \\gt 3.5σ significance at 1.2 mm. Our ALMA-selected sample has a median redshift of z=1.6+/- 0.4, with only one galaxy detected at z > 2 within the survey area. This value is significantly lower than that found in millimeter samples selected at a higher flux density cutoff and similar frequencies. Most galaxies have specific star formation rates (SFRs) similar to that of main-sequence galaxies at the same epoch, and we find median values of stellar mass and SFRs of 4.0× {10}10 {M}⊙ and ˜ 40 {M}⊙ yr-1, respectively. Using the dust emission as a tracer for the interstellar medium (ISM) mass, we derive depletion times that are typically longer than 300 Myr, and we find molecular gas fractions ranging from ˜0.1 to 1.0. As noted by previous studies, these values are lower than those using CO-based ISM estimates by a factor of ˜2. The 1 mm number counts (corrected for fidelity and completeness) are in agreement with previous studies that were typically restricted to brighter sources. With our individual detections only, we recover 55% ± 4% of the extragalactic background light (EBL) at 1.2 mm measured by the Planck satellite, and we recover 80% ± 7% of this EBL if we include the bright end of the number counts and additional detections from stacking. The stacked contribution is dominated by galaxies at z˜ 1{--}2, with stellar masses of (1-3) × 1010 M {}⊙ . For the first time, we are able to characterize the population of galaxies that dominate the EBL at 1.2 mm.

  6. Percent Wetland Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — Wetlands act as filters, removing or diminishing the amount of pollutants that enter surface water. Higher values for percent of wetland cover (WETLNDSPCT) may be...

  7. Percent Wetland Cover (Future)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Wetlands act as filters, removing or diminishing the amount of pollutants that enter surface water. Higher values for percent of wetland cover (WETLNDSPCT) may be...

  8. C1-2 arthrography

    Energy Technology Data Exchange (ETDEWEB)

    Chevrot, A. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Cermakova, E. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Vallee, C. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Chancelier, M.D. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Chemla, N. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Rousselin, B. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Langer-Cherbit, A. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France)

    1995-08-01

    One hundred patients with the following conditions were studied: cervical pain or neuralgia without radiographic changes, osteoarthritis, rheumatoid arthritis, ankylosing spondylarthritis and diverse conditions. The technique consists of lateral puncture of the posterior aspect of the C1-2 joint with a 20-gauge needle under fluoroscopic control, arthrography using 1 ml contrast medium, and a 1-ml long-acting steroid injection subsequently. The articular cavity has an anterior and a posterior recess. Sometimes the posterior recess is large. In 18% of cases the contralateral joint also opacifies. C1-2 arthrography appears to be an efficient and safe technique for the treatment of upper cervical pain due to C1-2 articular disorders. (orig.)

  9. 北京市场液体调味品中3-氯-1,2-丙二醇污染状况研究%Survey of 3-monochloropropane-1,2-diol in soysauce and similar products

    Institute of Scientific and Technical Information of China (English)

    金庆中; 张正; 罗仁才; 李洁; 周珊

    2001-01-01

    1999年英国等欧洲国家在中国及中国香港产的调味品中检测出较高含量的3-氯-1,2-丙二醇[3-monochloropropane-1,2-diol(简称3-MCPD)],根据英国FoodAdvisoryCommittee(FAC)的建议,已停止这些产品在英国的销售。本研究提供了在中国市场销售的部分液体调味品中的3-MCPD的污染状况,30种酱油、蚝油及类似产品于2000年3~4月购自北京6家超级市场,采用毛细管气相色谱-质谱法,方法的检出限为0.01mg/kg。在30种检测样品中15种未检测出3-MCPD;2种在比较低的水平(0.01~0.02mg/kg),5种在比较高的水平(>1mg/kg)。%A survey of 3-monochloropropane-1,2-diol (3-MCPD) in soy sauceand other similar products available in China has been completed. Thirty samples of soy, oyster sauce and other sauces were purchased from six supermarkets in Beijing during March and April 2000 and analysed using a validated method of analysis by capillary gas chromatography with mass spectrometric detection. The UK Food Advisory Committee (FAC) has advised a level of 0.01mg/kg for 3-MCPD. Following reports that high levels had been detected in some brands of soy sauce in China. 3-MCPD was undetectable with a detection limit of 0.01 mg/kg in 15 of the 30 samples analyzed in the survey, with a further 4 samples (13.3%) containing very low levels of between 0.01 and 0.02 mg/kg. However, 5 samples (16.7%) contained 3-MCPD levels above 1mg/kg.

  10. RHM 1(2).indb

    African Journals Online (AJOL)

    mike

    Research in Hospitality Management 2012, 1(2): 85–95. Printed in South ... This paper imagines what a hotel might look like in 2050 based upon nine drivers of ..... of a quarry, will be run by geothermal energy, use sustainable materials and ...

  11. Galaxies in x-ray selected clusters and groups in Dark Energy Survey Data I: Stellar mass growth of bright central galaxies since Z similar to 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.; Miller, C.; McKay, T.; Rooney, P.; Evrard, A. E.; Romer, A. K.; Perfecto, R.; Song, J; Desai, S.; Mohr, J. J.; Vikram, V.

    2016-01-10

    Using the science verification data of the Dark Energy Survey for a new sample of 106 X-ray selected clusters and groups, we study the stellar mass growth of bright central galaxies (BCGs) since redshift z similar to 1.2. Compared with the expectation in a semi-analytical model applied to the Millennium Simulation, the observed BCGs become under-massive/under-luminous with decreasing redshift. We incorporate the uncertainties associated with cluster mass, redshift, and BCG stellar mass measurements into an analysis of a redshift-dependent BCG-cluster mass relation, m(*) proportional to (M-200/1.5 x 10(14)M(circle dot))(0.24 +/- 0.08)(1+z)(-0.19 +/- 0.34), and compare the observed relation to the model prediction. We estimate the average growth rate since z = 1.0 for BCGs hosted by clusters of M-200,M-z = 10(13.8)M(circle dot); at z = 1.0: m(*, BCG) appears to have grown by 0.13 +/- 0.11 dex, in tension at the similar to 2.5 sigma significance level with the 0.40 dex growth rate expected from the semi-analytic model. We show that the build-up of extended intracluster light after z = 1.0 may alleviate this tension in BCG growth rates.

  12. Type Ia Supernovae in the Near-Infrared: A Three-Year Survey toward a One Percent Distance Measurement with WIYN+WHIRC

    Science.gov (United States)

    Wood-Vasey, Michael; Garnavich, Peter; Matheson, Thomas; Jha, Saurabh; Rest, Armin; Allen, Lori; Weyant, Anja; Marion, Howie

    2012-08-01

    We propose to observe 144 SNeIa in the near infrared (NIR) with 72 nights of WIYN+WHIRC in the 6 semesters of 2012B-2015A. Our goal is to create an infrared Hubble diagram extending from 0.02candles in the NIR. Assuming a conservative estimate of the observed intrinsic dispersion in H of 0.15 mag, 144 SNeIa will allow us to make a distance measurement of 1% at 300 Mpc. We will more extensively observe 30 of the nearest SNeIa to obtain detailed late-time light curves to measure SNIa color evolution in the near infrared where dust extinction is significantly reduced. In addition these NIR data will allow us to (1) Explore the recent correlation between optical luminosity and host galaxy mass; (2) Improve our understanding of intrinsic colors of SNeIa; (3) Compare high- resolution NIR spectra and photometry; (4) Study the nature of dust in galaxies beyond our Milky Way. This data set will provide a solid anchor for measuring luminosity distances in the Universe. Survey status will enable the required planning and organization for this large effort to most efficiently obtain the large number of SNeIa necessary for this precision distance measurement and to best coordinate with other complementary observations.

  13. PSCz-1.2 Jy Comparison: A Spherical Harmonics Approach

    OpenAIRE

    1999-01-01

    We perform a detailed comparison of the IRAS PSCz and 1.2-Jy spherical harmonic coefficients of the density and velocity fields in redshift space. The monopole terms predicted from the two surveys show some differences. The mismatch between the velocity monopoles arises from faint sources and disappears when extracting a PSCz subsample of galaxies with fluxes larger than 1.2 Jy. The analysis of PSCz dipole moments confirms the same inconsistencies found by Davis, Nusser and Willick (1996) bet...

  14. Percents Are Not Natural Numbers

    Science.gov (United States)

    Jacobs, Jennifer A.

    2013-01-01

    Adults are prone to treating percents, one representational format of rational numbers, as novel cases of natural number. This suggests that percent values are not differentiated from natural numbers; a conceptual shift from the natural numbers to the rational numbers has not yet occurred. This is most surprising, considering people are inundated…

  15. Inspiration: One Percent and Rising

    Science.gov (United States)

    Walling, Donovan R.

    2009-01-01

    Inventor Thomas Edison once famously declared, "Genius is one percent inspiration and ninety-nine percent perspiration." If that's the case, then the students the author witnessed at the International Student Media Festival (ISMF) last November in Orlando, Florida, are geniuses and more. The students in the ISMF pre-conference workshop had much to…

  16. 酱油中氨基甲酸乙酯和氯丙醇含量调查与分析%Survey and analysis of ethyl carbamate and 3-chloro-1,2-propanediol (3-MCPD) in soy sauce

    Institute of Scientific and Technical Information of China (English)

    王立媛; 吴平谷; 张晶; 汤鋆; 赵永信

    2012-01-01

    Objective:To investigate the levels of 3 - chloro - 1,2 - propanediol(3 - MCPD) and ethyl carbamate in soy sauce. Methods: The total 135 soy sauce samples were collected from big, middle - sized and small supermarkets and farmer's market respectively. The 3 - chloro - 1,2 - propanediol(3 - MCPD) and ethyl carbamate were measured by gas chromatography - mass spectrometry in selection ion mode, after the samples were coupled with D5 - ethyl carbamate and D5 - 3 - chloro -1,2- propanediol ( 3 - MCPD ) , and purified by diatomite solid phase extraction coulum. Results: The results showed that ethyl carbamate was detected in all samples ( 100% ) with the range from 1. 6 μg/kg to 80. 8 μg/kg,the 3 - chloro - 1,2 - propanediol( 3 - MCPD) was detected in 32.05% of the samples with the range from 5. 8 μg/kg to 379. 10 μg/kg. Conclusion: In this investigation, the ethyl carbamate was detected in all soy sauce samples, and the level of 3 - chloro - 1,2 - propanediol(3 - MCPD) was not pretty low, and the data obtained in our test can be the references for risk assessment of ethyl carbamate and 3 - chloro - 1 ,2 - propanediol in soy sauce.%目的:调查本地市售酱油中氯丙醇和氨基甲酸乙酯含量.方法:在本市大、中、小超市及农贸市场采集135份酱油,采用d5-3-氯-1,2-丙二醇、D5-氨基甲酸乙酯同位素稀释技术,硅藻土固相萃取净化样品,然后用GC/MS测定样品中氯丙醇和氨基甲酸乙酯.结果:135份酱油中氨基甲酸乙酯检出率100%,含量范围为1.6 μg/kg~80.8 μg/kg;氯丙醇检出率为32.05%,含量范围为5.8 μg/kg~ 379.10 μg/kg.结论:本次调查显示酱油中均存在氨基甲酸乙酯,氯丙醇检出含量也不低,为开展酱油中氨基甲酸乙酯和氯丙醇的风险评估提供了基础数据.

  17. Survey of commercially available chocolate- and cocoa-containing products in the United States. 2. Comparison of flavan-3-ol content with nonfat cocoa solids, total polyphenols, and percent cacao.

    Science.gov (United States)

    Miller, Kenneth B; Hurst, W Jeffrey; Flannigan, Nancy; Ou, Boxin; Lee, C Y; Smith, Nancy; Stuart, David A

    2009-10-14

    A survey of a broad range of chocolate- and cocoa-containing products marketed in the United States was conducted to provide a more detailed analysis of flavan-3-ol monomers, oligomers, and polymers, which can be grouped into a class of compounds called procyanidins. Samples consisted of the three or four top-selling products within the following six categories: natural cocoa powder, unsweetened baking chocolate, dark chocolate, semisweet baking chips, milk chocolate, and chocolate syrup. Composite samples were characterized for percent fat (% fat), percent nonfat cocoa solids (% NFCS), antioxidant level by ORAC, total polyphenols, epicatechin, catechin, total monomers, and flavan-3-ol oligomers and polymers (procyanidins). On a gram weight basis epicatechin and catechin content of the products follow in decreasing order: cocoa powder > baking chocolate > dark chocolate = baking chips > milk chocolate > chocolate syrup. Analysis of the monomer and oligomer profiles within product categories shows there are two types of profiles: (1) products that have high monomers with decreasing levels of oligomers and (2) products in which the level of dimers is equal to or greater than the monomers. Results show a strong correlation (R(2) = 0.834) of epicatechin to the level of % NFCS and also very good correlations for N = 2-5 oligomers to % NFCS. A weaker correlation was observed for catechin to % NFCS (R(2) = 0.680). Other analyses show a similar high degree of correlation with epicatechin and N = 2-5 oligomers to total polyphenols, with catechin being less well correlated to total polyphenols. A lesser but still good correlation exists between the calculated percent cacao (calcd % cacao) content, a proxy for percent cacao, and these same flavanol measures, with catechin again showing a lesser degree of correlation to calcd % cacao. Principal component analysis (PCA) shows that the products group discretely into five classes: (1) cocoa powder, (2) baking chocolate, (3) dark

  18. ROE Fish Faunal Percent Loss

    Data.gov (United States)

    U.S. Environmental Protection Agency — Percent reduction is based on the number of native species determined to be present as of 2015, compared with historical numbers documented prior to 1970. Data are...

  19. Spin-1/2 Maxwell Fields

    CERN Document Server

    Armour, R S

    2003-01-01

    Requiring covariance of Maxwell's equations without {\\it a priori} imposing charge invariance allows for both spin-1 and spin-1/2 transformations of the complete Maxwell field and current. The spin-1/2 case yields new transformation rules, with new invariants, for all traditional Maxwell field and source quantities. The accompanying spin-1/2 representations of the Lorentz group employ the Lorentz metric, and consequently the primary invariants of the spin-1/2 Maxwell field are also spin-1 invariants, for example, $\\Phi^2 - {\\bf A}^2$, ${\\bf E}^2 - {\\bf B}^2 + 2i {\\bf E} \\bm{\\cdot} {\\bf B} - ({\\partial}_{0}{\\Phi} + {\\bm{\

  20. AC conductivity and relaxation mechanism in (Nd1/2Li1/2)(Fe1/2V1/2)O3 ceramics

    Science.gov (United States)

    Nath, Susmita; Barik, Subrat Kumar; Choudhary, R. N. P.

    2016-05-01

    In the present study we have synthesized polycrystalline sample of (Nd1/2Li1/2)(Fe1/2V1/2)O3 ceramic by a standard high-temperature solid-state reaction technique. Studies of dielectric and electrical properties of the compound have been carried out in a wide range of temperature (RT - 400 °C) and frequency (1kHz - 1MHz) using complex impedance spectroscopic technique. The imaginary vs. real component of the complex impedance plot (Nyquist plot) of the prepared sample exhibits the existence of grain, grain boundary contributions in the complex electrical parameters and negative temperature coefficient of resistance (NTCR) type behavior like semiconductor. Details study of ac conductivity plot reveals that the material obeys universal Jonscher's power law.

  1. The Einstein All-Sky Slew Survey

    Science.gov (United States)

    Elvis, Martin S.

    1992-01-01

    The First Einstein IPC Slew Survey produced a list of 819 x-ray sources, with f(sub x) approximately 10(exp -12) - 10(exp -10) erg/sq cm s and positional accuracy of approximately 1.2 feet (90 percent radius). The aim of this program was to identify these x-ray sources.

  2. Spin 1/2 and Invariant Coefficients

    OpenAIRE

    Shurtleff, Richard

    2004-01-01

    Massive spin 1/2 particles require 2-spinors for rotations, 4-spinors for rotations and boosts with parity. Including translations requires 8-spinors. Adapting 4-spinor field theory to 8-spinor fields with translation symmetry is discussed here. It is shown that four of these spin components act like conventional 4-spinors, satisfying the conventional free-particle Dirac equation. The remaining four components have unconventional coordinate dependence due to translation symmetry. One finds th...

  3. ERF1_2 -- Enhanced River Reach File 2.0

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The digital segmented network based on watershed boundaries, ERF1_2, includes enhancements to the U.S. Environmental Protection Agency's River Reach File 1 (RF1)...

  4. Surficial geology of the Cabot 7 1/2 minute quadrangle, Vermont

    Data.gov (United States)

    Vermont Center for Geographic Information — Digital data from VG2016-3 Springston, G., 2016, Surficial geology of the Cabot 7 1/2 minute quadrangle, Vermont: Vermont Geological Survey Open File Report...

  5. The stereodynamics of 1,2-dipropyldiaziridines.

    Science.gov (United States)

    Trapp, Oliver; Sahraoui, Laila; Hofstadt, Werner; Könen, Werner

    2010-02-01

    N-alkylated trans-diaziridines are an intriguing class of compounds with two stereogenic nitrogen atoms which easily interconvert. In the course of our investigations of the nature of the interconversion process via nitrogen inversion or electrocyclic ring opening ring closure, we synthesized and characterized the three constitutionally isomeric diaziridines 1,2-di-n-propyldiaziridine 1, 1-isopropyl-2-n-propyldiaziridine 2, and 1,2-diisopropyldiaziridine 3 to study the influence of the substituents on the interconversion barriers. Enantiomer separation was achieved by enantioselective gas chromatography on the chiral stationary phase Chirasil-beta-Dex with high separation factors alpha (1-isopropyl-2-n-propyldiaziridine: 1.18; 1, 2-diisopropyldiaziridine: 1.24; 100 degrees C 50 kPa He) for the isopropyl substituted diaziridines. These compounds showed pronounced plateau formation between 100 and 150 degrees C, and peak coalescence at elevated temperatures. The enantiomerization barriers DeltaG(double dagger) and activation parameters DeltaH(double dagger) and DeltaS(double dagger) were determined by enantioselective dynamic gas chromatography (DGC) and direct evaluation of the elution profiles using the unified equation implemented in the software DCXplorer. Interestingly, 1-isopropyl-2-n-propyldiaziridine and 1,2-diisopropyldiaziridine exhibit similar high interconversion barriers DeltaG(double dagger) (100 degrees C) of 128.3 +/- 0.4 kJ mol(-1) and 129.8 +/- 0.4 kJ mol(-1), respectively, which indicates that two sterically demanding substituents do not substantially increase the barrier as expected for a distinct nitrogen inversion process.

  6. James Lee Byars 1/2 an autobiography, sourcebook

    CERN Document Server

    Byars, James Lee; Eleey, Peter

    2014-01-01

    "I see my autobiography as an arbitrary segment of so many pages of time, of things that I have paid attention to at this point in my life," wrote James Lee Byars (1932-1997) in 1969. He was then 37, about half the average male lifespan at the time, and accordingly thought it appropriate to write his "1/2 autobiography." Byars' art ranged from highly refined objects to extremely minimal performance and events, and books, ephemera and correspondence that he distributed widely among friends and colleagues. Today, more than 15 years after his death, assessments of his art must negotiate Byars' performance of his charismatic self in his life and art. For his first major posthumous survey in the US, exhibition curators Magalí Arriola and Peter Eleey decided to produce a catalogue in two "halves," playing on his "1/2 autobiography": a catalogue of the exhibition itself, including new scholarship, and a sourcebook of primary documents. 1/2 an Autobiography, Sourcebook constitutes the latter volume--a reference guid...

  7. Taming the 1.2 m Telescope

    Science.gov (United States)

    Griffin, S.; Edwards, M.; Greenwald, D.; Kono, D.; Liang, D.; Lohnes, K.; Wright, V.; Spillar, E.

    2013-09-01

    Achievable residual jitter on the 1.2 m telescope at MSSS shown in Figure 1 has historically been limited to 10-20 arc-sec. peak in moderate wind conditions due to the combination of the dynamics associated with the twin telescopes on the common declination axis shaft, and the related control system behavior. Figure 1 1.2 m Telescope The lightly damped, low frequency fundamental vibration mode shape of the telescopes rotating out of phase on the common declination axis shaft severely degraded the performance of the prior controllers. This vibration mode is easily excited by external forces such as wind loading and internal torque commands from the mount control system. The relatively poor historic performance was due to a combination of the low error rejection of external disturbances, and the controller exciting the mode. A radical new approach has been implemented that has resulted in a decrease of jitter to less than 1 arcsec under most conditions. The new approach includes minor hardware modifications to provide active damping with accelerometers as feedback sensors. This architecture has allowed a bandwidth increase of almost an order of magnitude and eliminated the large amplitude motions at the mode natural frequency, resulting in much improved pointing and jitter performance. A representative comparison of historical versus new architecture performance is shown in Figure 2 for the declination axis.

  8. 1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.

    Science.gov (United States)

    Jocher, Christoph J; Moore, Evan G; Xu, Jide; Avedano, Stefano; Botta, Mauro; Aime, Silvio; Raymond, Kenneth N

    2007-10-29

    1,2-Hydroxypyridinones (1,2-HOPO) form very stable lanthanide complexes that may be useful as contrast agents for magnetic resonance imaging (MRI). X-ray diffraction of single crystals established that the solid-state structures of the Eu(III) and the previously reported [Inorg. Chem. 2004, 43, 5452] Gd(III) complex are identical. The recently discovered sensitizing properties of 1,2-HOPO chelates for Eu(III) luminescence [J. Am. Chem. Soc. 2006, 128, 10 067] allow for direct measurement of the number of water molecules coordinated to the metal center. Fluorescence measurements of the Eu(III) complex corroborate that, in solution, two water molecules coordinate the lanthanide (q = 2) as proposed from the analysis of NMRD profiles. In addition, fluorescence measurements have verified the anion binding interactions of lanthanide TREN-1,2-HOPO complexes in solution, studied by relaxivity, revealing only very weak oxalate binding (KA = 82.7 +/- 6.5 M-1). Solution thermodynamic studies of the metal complex and free ligand have been carried out using potentiometry, spectrophotometry, and fluorescence spectroscopy. The metal ion selectivity of TREN-1,2-HOPO supports the feasibility of using 1,2-HOPO ligands for selective lanthanide binding [pGd = 19.3 (2), pZn = 15.2 (2), pCa = 8.8 (3)].

  9. The Algebra of the Cumulative Percent Operation.

    Science.gov (United States)

    Berry, Andrew J.

    2002-01-01

    Discusses how to help students avoid some pervasive reasoning errors in solving cumulative percent problems. Discusses the meaning of ."%+b%." the additive inverse of ."%." and other useful applications. Emphasizes the operational aspect of the cumulative percent concept. (KHR)

  10. Alzheimer's Deaths Jump 55 Percent: CDC

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_165941.html Alzheimer's Deaths Jump 55 Percent: CDC More patients also ... News) -- As more baby boomers age, deaths from Alzheimer's disease have jumped 55 percent, and in a ...

  11. PRIze{sup TM} 1.2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    PRIze{sup TM} 1.2 is a computer program that evaluates the improved oil recovery (IOR) potential of petroleum reservoirs including the use of horizontal wells. It was created in 1992 and has since been used in over 800 reservoir evaluations. The tool provides information on the feasibility of IOR processes based on reservoir parameters. PRIze{sup TM} makes predictions for chemical, gas injection and thermal IOR processes based on both vertical and horizontal wells. The program provides a uniform data entry screen that allows the user to input 42 average values of geological parameters, fluid properties and oil production mechanism information into a data file. The data can be used to provide a production forecast, and enable the user to establish, to a first order approximation, the economic viability of a given process.

  12. 1,2-Bis(N′-benzoylthioureidobenzene

    Directory of Open Access Journals (Sweden)

    Aliou Hamady Barry

    2008-05-01

    Full Text Available The title compound, C22H18N4O2S2, was characterized by 1H and 13C NMR, solid-state IR spectroscopy and X-ray crystallographic techniques. The crystal structure determination reveals that the twisting modes of the two side arms are different [C—N—C—O and C—N—C—N torsion angles = −1.2 (3 and 1.1 (3°, respectively, in one arm and 24.1 (3 and −5.1 (3°, respectively, in the other]. The crystal structure involves N—H...O and N—H...S hydrogen bonds.

  13. Electrical properties of Ba(Dy1/2Nb1/2)O3 ceramic

    Science.gov (United States)

    Nath, K. Amar; Chandra, K. P.; Dubey, K.; Prasad, K.

    2016-05-01

    Polycrystalline Ba(Dy1/2Nb1/2)O3 was prepared using a high-temperature solid-state reaction method. X-ray diffraction analysis indicated the formation of a single-phase cubic structure having space group Pm3m. AC impedance plots as a function of frequency at different temperatures were used to analyse the electrical behaviour of the sample, which indicated the negative temperature coefficient of resistance character. Complex impedance analysis targeted non-Debye type dielectric relaxation. Frequency dependent ac conductivity data obeyed Jonscher's power law. The apparent activation energy was estimated to be 0.97 eV at 1 kHz.

  14. Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes.

    Science.gov (United States)

    Li, Meina; Kong, Duanyang; Zi, Guofu; Hou, Guohua

    2017-01-06

    A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

  15. 5 CFR 1.2 - Extent of the competitive service.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Extent of the competitive service. 1.2 Section 1.2 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.2 Extent of the competitive service. The competitive service shall include: (a) All...

  16. 1,2 Migration in Carbenoid and Carbene Reactions

    Institute of Scientific and Technical Information of China (English)

    MA Ming; JIANG Nan; SHI Wei-Feng; WANG Jian-Bo

    2003-01-01

    @@ 1,2-Hydride, 1,2-alkyl and 1,2-aryl migrations are common in free carbene chemistry, and they are also fre quently encountered in the reactions of metal carbenes. In some cases, these migration reactions can compete with the typical reactions of metal carbenes, such as X-H (X = Si, C, O, N, S, etc. ) insertions and cyclopropanations. [1] The 1,2-migration also found synthetic application. An example is the SnCl2-promoted 1,2-hydride migration of α-diazo-β-hydroxy esters, known as Roskamp homologation, which leads to the formation of β-keto esters. [2

  17. Stellwagen Bank bathymetry - Percent slope derived from 5-meter bathymetric contour lines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Percent slope of Stellwagen Bank bathymetry. Raster derived from 5-meter bathymetric contour lines (Quads 1-18). Collected on surveys carried out in 4 cruises 1994 -...

  18. Riparian vegetation abundance (percent cover) in the Elwha River estuary, Washington, in 2007 and 2014

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This portion of the data release presents riparian plant species abundance (percent cover) data from plots sampled in the Elwha River estuary, Washington, in 2007...

  19. Estimating a percent reduction in load

    Science.gov (United States)

    Millard, Steven P.

    This article extends the work of Cohn et al. [1989] on estimating constituent loads to the problem of estimating a percent reduction in load. Three estimators are considered: the maximum likelihood (MLE), a ``bias-corrected'' maximum likelihood (BCMLE), and the minimum variance unbiased (MVUE). In terms of root-mean-square error, both the MVUE and BCMLE are superior to the MLE, and for the cases considered here there is no appreciable difference between the MVUE and the BCMLE. The BCMLE is constructed from quantities computed by most regression packages and is therefore simpler to compute than the MVUE (which involves approximating an infinite series). All three estimators are applied to a case study in which an agricultural tax in the Everglades agricultural area is tied to an observed percent reduction in phosphorus load. For typical hydrological data, very large sample sizes (of the order of 100 observations each in the baseline period and after) are required to estimate a percent reduction in load with reasonable precision.

  20. Genetics and biochemistry of 1,2-dichloroethane degradation

    NARCIS (Netherlands)

    Janssen, Dick B.; Ploeg, Jan R. van der; Pries, Frens

    1994-01-01

    Dichloroethane (1,2-DCE) is a synthetic compound that is not known to be formed naturally. Nevertheless, several pure microbial cultures are able to use it as a sole carbon source for growth. Degradation of 1,2-DCE proceeds via 2-chloroethanol, chloroacetaldehyde and chloroacetate to glycolate. The

  1. 40 CFR 721.10057 - Dodecanedioic acid, 1, 12-dihydrazide.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Dodecanedioic acid, 1, 12-dihydrazide... Specific Chemical Substances § 721.10057 Dodecanedioic acid, 1, 12-dihydrazide. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as dodecanedioic acid, 1,...

  2. Genetics and biochemistry of 1,2-dichloroethane degradation

    NARCIS (Netherlands)

    Janssen, Dick B.; Ploeg, Jan R. van der; Pries, Frens

    1994-01-01

    Dichloroethane (1,2-DCE) is a synthetic compound that is not known to be formed naturally. Nevertheless, several pure microbial cultures are able to use it as a sole carbon source for growth. Degradation of 1,2-DCE proceeds via 2-chloroethanol, chloroacetaldehyde and chloroacetate to glycolate. The

  3. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU Peter C; WANG Dei-Haw; LU Kaitao; MANI Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis (dibromomethyl) benzenes with fuming sulfuric acid, followed by hydrolysis, The yields were significantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  4. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU; Peter; C; WANG; Der-Haw; MANI; Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis(dibromomethyl) benzenes with fuming sulfuric acid,followed by hydrolysis. The yields were signifi-cantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  5. 1,2-Selective Hydrosilylation of Conjugated Dienes

    OpenAIRE

    Parker, Sarah Elizabeth

    2014-01-01

    Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior coupling reagents for hybrid organic/inorganic materials synthesis. In this thesis, we describe the first selective 1,2-hydrosilylation of conjugated dienes, including butadiene.

  6. Dihydroxylation of 4-substituted 1,2-dioxines

    DEFF Research Database (Denmark)

    Robinson, Tony V; Pedersen, Daniel Sejer; Taylor, Dennis K;

    2009-01-01

    The synthesis of 2-C-branched erythritol derivatives, including the plant sugar (+/-)-2-C-methylerythritol 2, was achieved through a dihydroxylation/reduction sequence on a series of 4-substituted 1,2-dioxines 3. The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to opt...

  7. The LDA-1/2 technique: Recent developments

    Science.gov (United States)

    Ferreira, Luiz G.; Pelá, Ronaldo R.; Teles, Lara K.; Marques, Marcelo; Ribeiro, Mauro, Jr.; Furthmüller, Jürgen

    2013-12-01

    This paper is a review of the LDA(GGA)-1/2 method for band calculation. We review the many applications of the method: band gaps, semiconductor interfaces, semiconductor alloys. The number of applications where the method fails is minimal. Leading to results with a precision comparable to Hedin's GW method, LDA-1/2 has the advantage of being orders of magnitude faster. The paper begins by a short theoretical review in which we try not repeat what is already published. Then we present some results that are scattered in the literature. We find that LDA(GGA)-1/2 is the recommended method for excited state energy calculations.

  8. Global Precipitation Climatology Project (GPCP) - Daily, Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Precipitation Climatology Project (GPCP) comprises a total of 27 products. The Version 1.2 Daily product covers the period October 1998 to the present,...

  9. SU(1,2) invariance in two-dimensional oscillator

    CERN Document Server

    Krivonos, Sergey

    2016-01-01

    Performing the Hamiltonian analysis we explicitly established the canonical equivalence of the deformed oscillator, constructed in arXiv:1607.03756[hep-th], with the ordinary one. As an immediate consequence, we proved that the SU(1,2) symmetry is the dynamical symmetry of the ordinary two-dimensional oscillator. The characteristic feature of this SU(1,2) symmetry is a non-polynomial structure of its generators written it terms of the oscillator variables.

  10. 15 CFR 1.2 - Description and design.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Description and design. 1.2 Section 1... COMMERCE § 1.2 Description and design. (a) The Act of February 14, 1903 (32 Stat. 825, as amended) (15 U.S... the words: Department of Commerce United States of America (b) The design of the approved seal is as...

  11. 1,2-Bis(2-methoxy-6-formylphenoxyethane

    Directory of Open Access Journals (Sweden)

    Hongqi Li

    2011-02-01

    Full Text Available In the title compound [systematic name: 3,3′-dimethoxy-2,2′-(ethane-1,2-diyldioxydibenzaldehyde], C18H18O6, prepared from 1,2-dibromoethane and ortho-vanillin in the presence of sodium carbonate, the two vanillin units are linked via a CH2–CH2 bridge. The two benzene rings are inclined at a dihedral angle of 41.6 (5°.

  12. How I Love My 80 Percenters

    Science.gov (United States)

    Maturo, Anthony J.

    2002-01-01

    Don't ever take your support staff for granted. By support staff, I mean the people in personnel, logistics, and finance; the ones who can make things happen with a phone call or a signature, or by the same token frustrate you to no end by their inaction; these are people you must depend on. I've spent a lot of time thinking about how to cultivate relationships with my support staff that work to the advantage of both of us. The most important thing that have learned working with people, any people--and I will tell you how I learned this in a minute--is there are some folks you just can't motivate, so forget it, don't try; others you certainly can with a little psychology and some effort; and the best of the bunch, what I call the 80 percenters, you don't need to motivate because they're already on the team and performing beautifully. The ones you can't change are rocks. Face up to it, and just kick them out of your way. I have a reputation with the people who don't want to perform or be part of the team. They don't come near me. If someone's a rock, I pick up on it right away, and I will walk around him or her to find someone better. The ones who can be motivated I take time to nurture. I consider them my projects. A lot of times these wannabes are people who want to help but don't know how. Listen, you can work with them. Lots of people in organizations have the mindset that all that matters are the regulations. God forbid if you ever work outside those regulations. They've got one foot on that regulation and they're holding it tight like a baby holds a blanket. What you're looking for is that first sign that their minds are opening. Usually you hear it in their vocabulary. What used to sound like "We can't do that ... the regulations won't allow it ... we have never done this before," well, suddenly that changes to "We have options ... let's take a look at the options ... let me research this and get back to you." The 80 percenters you want to nurture too, but

  13. 基于WalkSurvey软件的1:2000比例尺地形图数字化缩编技术的实现%Implementation of 1:2 000 Scale Digital Topographic Map Downsizing Technology Based on WalkSurvey Software

    Institute of Scientific and Technical Information of China (English)

    王海江

    2013-01-01

    In order to bet er meet the needs of city planning and construction, using the existing 1:500, 1:1 000 large scale topographic map downsizing into 1:2 000 scale topographic map, is a way of both economical and efficient and easy access to smal scale topographic map. This paper focuses on realizat-ion method of the technology making exist large scale map ge-neralized to 1:2 000 digital topographic map.%为了更好地满足城市规划建设的需要,利用现有的1:500、1:1000大比例尺地形图缩编成1:2000比例尺的地形图是既经济节约又高效方便地获取小比例尺地形图的一种途径,本文就重点叙述了本院将现有大比例图缩编成1:2000数字地形图的技术实现方法。

  14. Measurement and Correlation of Vapor-Liquid Equilibrium for Binary System 1,2-Epoxycyclohexane+1,2-Dichloroethane

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 王海峰; 石晓华; 蒋登高

    2013-01-01

    Vapor-liquid equilibrium data (T, x, y) of binary system 1,2-epoxycyclohexane+1,2-dichloroethane were determined experimentally by using a modified ROSE-Williams equilibrium vaporization system at 101.33 kPa. The results show that this binary system does not have azeotropic point. The vapor-liquid equilibrium data are in thermodynamic consistency. The binary interaction parameters in the Wilson equation are presented with the correlation of vapor-liquid equilibrium data. The measurements of liquid phase composition and bubble point tem-perature are well represented by the Wilson equation. Values of vapor molecular fractions and activity coefficients from the Wilson equation are presented. This work provides important engineering data for the separation of 1,2-dichloroethane and 1,2-epoxycyclohexane .

  15. Dielectric relaxation in 0-3 PVDF-Ba(Fe1/2Nb1/2)O3 composites

    Science.gov (United States)

    Chandra, K. P.; Singh, Rajan; Kulkarni, A. R.; Prasad, K.

    2016-05-01

    (1-x)PVDF-xBa(Fe1/2Nb1/2)O3 ceramic-polymer composites with x = 0.025, 0.05, 0.10, 0.15 were prepared using melt-mixing technique. The crystal symmetry, space group and unit cell dimensions were determined from the XRD data of Ba(Fe1/2Nb1/2)O3 using FullProf software, whereas crystallite size and lattice strain were estimated using Williamson-Hall approach. The distribution of Ba(Fe1/2Nb1/2)O3 particles in the PVDF matrix were examined on the cryo-fractured surfaces using a scanning electron microscope. Cole-Cole and pseudo Cole-Cole analysis suggested the dielectric relaxation in this system to be of non-Debye type. Filler concentration dependent real and imaginary parts of dielectric constant as well as ac conductivity data followed definite trends of exponential growth types of variation.

  16. Percent area coverage through image analysis

    Science.gov (United States)

    Wong, Chung M.; Hong, Sung M.; Liu, De-Ling

    2016-09-01

    The notion of percent area coverage (PAC) has been used to characterize surface cleanliness levels in the spacecraft contamination control community. Due to the lack of detailed particle data, PAC has been conventionally calculated by multiplying the particle surface density in predetermined particle size bins by a set of coefficients per MIL-STD-1246C. In deriving the set of coefficients, the surface particle size distribution is assumed to follow a log-normal relation between particle density and particle size, while the cross-sectional area function is given as a combination of regular geometric shapes. For particles with irregular shapes, the cross-sectional area function cannot describe the true particle area and, therefore, may introduce error in the PAC calculation. Other errors may also be introduced by using the lognormal surface particle size distribution function that highly depends on the environmental cleanliness and cleaning process. In this paper, we present PAC measurements from silicon witness wafers that collected fallouts from a fabric material after vibration testing. PAC calculations were performed through analysis of microscope images and compare them to values derived through the MIL-STD-1246C method. Our results showed that the MIL-STD-1246C method does provide a reasonable upper bound to the PAC values determined through image analysis, in particular for PAC values below 0.1.

  17. The Einstein Slew Survey

    Science.gov (United States)

    Elvis, Martin; Plummer, David; Schachter, Jonathan; Fabbiano, G.

    1992-01-01

    A catalog of 819 sources detected in the Einstein IPC Slew Survey of the X-ray sky is presented; 313 of the sources were not previously known as X-ray sources. Typical count rates are 0.1 IPC count/s, roughly equivalent to a flux of 3 x 10 exp -12 ergs/sq cm s. The sources have positional uncertainties of 1.2 arcmin (90 percent confidence) radius, based on a subset of 452 sources identified with previously known pointlike X-ray sources (i.e., extent less than 3 arcmin). Identifications based on a number of existing catalogs of X-ray and optical objects are proposed for 637 of the sources, 78 percent of the survey (within a 3-arcmin error radius) including 133 identifications of new X-ray sources. A public identification data base for the Slew Survey sources will be maintained at CfA, and contributions to this data base are invited.

  18. BRCA1/2 associated hereditary breast cancer

    Institute of Scientific and Technical Information of China (English)

    Li-song TENG; Yi ZHENG; Hao-hao WANG

    2008-01-01

    Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes,focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial;further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

  19. Extended cluster spin-1/2 XXZ chain

    Science.gov (United States)

    Tahvili, Masoumeh; Mahdavifar, Saeed

    2017-01-01

    We study the quantum phase transitions in the extended cluster spin-1/2 XXZ chain, which is equivalent to a 1D spin-1/2 XXZ model with three-spin interaction. The ground state phase diagram of the 1D spin-1/2 anisotropic XXZ model is known. Depending on the value of the anisotropy parameter, the ground state exhibits the ordering of the Luttinger liquid (LL), the Neel and the saturated ferromagnetic phases. In the absence of the anisotropy, it was shown that the three-spin interaction induces a quantum phase transition between two kinds of the LL phases. In the presence of the anisotropy, by using the analytical and numerical methods, the extended ground state phase diagram of the model is obtained.

  20. 3-[Chloro(phenylmethyl]-6-methyl-1,2-benzoxazole

    Directory of Open Access Journals (Sweden)

    M. Kayalvizhi

    2011-11-01

    Full Text Available The title compound, C15H12ClNO, is a functionalized 1,2-benzoxazole with a chloro(phenylmethyl substituent. The molecule is V-shaped, the dihedral angle between the mean plane of the 1,2-benzoxazole system [maximum deviation = 0.023 (3 Å for the N atom] and the phenyl ring being 70.33 (14°. There are no hydrogen-bonding interactions in the crystal structure, which is stabilized by van der Waals interactions only.

  1. An Efficient Preparation of 1,2-Diamino-1-phenylheptane

    Directory of Open Access Journals (Sweden)

    P. T. Perumal

    2002-06-01

    Full Text Available A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1 to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3 is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4 is also reported for the first time.

  2. 36 CFR 1.2 - Applicability and scope.

    Science.gov (United States)

    2010-07-01

    ... to the jurisdiction of the United States located within the boundaries of the National Park System... Section 1.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL... administered by the National Park Service; (2) The boundaries of lands and waters administered by the...

  3. Synthesis of Poly(m-pyridylene-1,2-diphenylvinylene

    Directory of Open Access Journals (Sweden)

    Rosana S. Montani

    2000-03-01

    Full Text Available The synthesis by dehalogenating polycondensation and characterization of a new soluble conjugated polymer, poly(m-pyridylene-1,2-diphenylvinylene, DP-PPyV, is reported here. It shows good mechanical properties and a λmax = 330 nm. The maximum intensity peak of MALDI-TOF corresponds to 1.800 Da.

  4. Spin diffusion in anisotropic Heisenberg chains: S{>=}1/2

    Energy Technology Data Exchange (ETDEWEB)

    Huber, D.L., E-mail: huber@src.wisc.edu [Physics Department, University of Wisconsin-Madison, 1150 University Avenue, Madison WI 53706 (United States)

    2012-11-01

    In this paper, we investigate spin diffusion in Heisenberg chains with uniaxial nearest-neighbor interactions. The approach followed is based on an analysis of the infinite-temperature longitudinal spin density and spin current correlation functions. For S=1/2, exact results are presented for the time-dependent correlation functions in the XY limit. Away from this limit, the second and fourth moments of the Fourier transform of the spin density correlation function provide information about spin dynamics for arbitrary values of the spin. The moments are used in an assessment of the accuracy of the Gaussian approximation for the spin diffusion constant for S=1/2. The general behavior of the Gaussian approximation when S>1/2 is discussed, and numerical results for the spin diffusion constant are presented for S=1/2, 1, 3/2, 2 and in the classical limit. A moment-based criterion for the boundary in reciprocal space between diffusive and non-diffusive dynamics that applies to arbitrary values of the spin is presented.

  5. A Superfield Formalism of osp(1,2) Covariant Quantization

    CERN Document Server

    Lavrov, P M

    2001-01-01

    We propose a superfield description of osp(1,2) covariant quantization by extending the set of admissibility conditions for the quantum action. We realize a superfield form of the generating equations, specify the vacuum functional and obtain the corresponding transformations of extended BRST symmetry.

  6. Biochemical activities of 1,2-dichloroethane (DCA) degrading bacteria

    African Journals Online (AJOL)

    African Journal of Biotechnology ... One of the most widely produced industrial solvents is 1,2-dichloroethane (DCA), a known ... Annual production in the United States, Japan and Europe alone are in excess of ... isolated from South African waste water treatment facilities, were found to belong to the genus Ancylobacter.

  7. The Addition of Bromine to 1,2-Diphenylethene

    Science.gov (United States)

    Amburgey-Peters, Judith C.; Haynes, Leroy W.

    2005-01-01

    The bromination of 1,2-diphenylethene, using a variety of solvents and brominating agents, can be used in both introductory and advanced organic chemistry courses. The reactions can be used to illustrate the effects of changing solvents and reagents, as well as to reveal interesting aspects of organic reaction mechanisms.

  8. Review of five successful microbial geochemical surface surveys in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Munnecke, D.M. [Environmental BioTechnologies Inc., San Carlos, CA (United States)

    1999-11-01

    The development of a new surface geochemical survey technology to detect hydrocarbon microseeps was discussed. Microbial Exploration Technology (MET) was developed by Environmental BioTechnologies Inc., of San Carlos, California. It is used to determine the near surface soil`s metabolic activity towards metabolism of gaseous hydrocarbons. After several years of testing, the technology was commercialized in Canada in 1996. Since then, more than 3 million acres of land in Canada have been surveyed using MET. Surveys are conducted by collecting soil samples in a quarter by quarter mile grid pattern. The samples are then sent to California for analysis. One of the unique characteristics of MET is that it provides a contour map indicating the percent probability of drilling success. This paper presented the following five MET surveys as examples of what types of results can be obtained from the surveys: (1) Flinton Survey (T11 R6 W2), (2) Elcott Survey (T1-2 R1-3 W2), (3) Silverton Survey (T3 R32 W1), (4) Swift Current Block (T13-15 R10-R13 W3), and (5) Border Block (T1-2 R12-14 W3). Each example demonstrates that MET can be very supportive for oil and gas exploration and exploitation activities. It was suggested that running MET surveys before seismic surveys helps in determining where seismic surveys should be conducted to reduce overall exploration costs by 30 to 60 per cent, while improving drilling success. 6 figs.

  9. New Features in CMMI V1.2%CMMI V1.2 版本的新特征

    Institute of Scientific and Technical Information of China (English)

    许东; 刘宗田

    2007-01-01

    最新发布的CMMI V1.2 模型做了很多的改进.将原先的模型CMMI-SE/SW/IPPD进行了整合,更改了模型的名称:CMMI-SE/SW/改为用于开发的CMMI模型CMMI-DEV v1.2.CMMI v1.2 产品集支持开发、服务和获取过程,CMMI-DEV是其中的一种并首先发布,其它的CMMI套件在2007年陆续发布."附加"是用来扩展模型的,如CMMI-DEV+IPPD,表示某些过程域是和IPPD中的目标和实践结合起来使用.新版本还将CMMI的两种表示方式(连续和阶段式)合并在一个文档中表述.在CMMI V1.2 版本中,模型的表述、术语、过程域都有相应的改进.

  10. HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex

    Directory of Open Access Journals (Sweden)

    Swanson Patrick C

    2009-03-01

    Full Text Available Abstract Background V(DJ recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG and nonamer (consensus: 5'-ACAAAAACC motifs separated by either 12- or 23-base pairs of poorly conserved sequence. The high mobility group proteins HMGB1 and HMGB2 (HMGB1/2 are highly abundant architectural DNA binding proteins known to promote RAG-mediated synapsis and cleavage of consensus recombination signals in vitro by facilitating RSS binding and bending by the RAG1/2 complex. HMGB1/2 are known to recognize distorted DNA structures such as four-way junctions, and damaged or modified DNA. Whether HMGB1/2 can promote RAG-mediated DNA cleavage at sites lacking a canonical RSS by targeting or stabilizing structural distortions is unclear, but is important for understanding the etiology of chromosomal translocations involving antigen receptor genes and proto-oncogene sequences that do not contain an obvious RSS-like element. Results Here we identify a novel DNA breakpoint site in the plasmid V(DJ recombination substrate pGG49 (bps6197 that is cleaved by the RAG proteins via a nick-hairpin mechanism. The bps6197 sequence lacks a recognizable heptamer at the breakpoint (5'-CCTGACG-3' but contains a nonamer-like element (5'-ACATTAACC-3' 30 base pairs from the cleavage site. We find that RAG-mediated bps6197 cleavage is promoted by HMGB1/2, requiring both HMG-box domains to be intact to facilitate RAG-mediated cleavage, and is stimulated by synapsis with a 12-RSS. A dyad-symmetric inverted repeat sequence lying 5' to the breakpoint is implicated as a target for HMGB1/2 activity. Conclusion We have identified a novel DNA sequence, called bps6197, that supports standard V(DJ-type cleavage despite the absence of an apparent heptamer motif. Efficient RAG-mediated bps6197 cleavage requires the presence of HMGB1/2, is stimulated by synapsis with a 12-RSS partner, and is directed in part by an inverted repeat sequence adjacent to the DNA cleavage site. These results have important implications for understanding how the RAG proteins can introduce a DNA double-strand break at DNA sequences that do not contain an obvious heptamer-like motif.

  11. HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.

    Science.gov (United States)

    Zhang, Ming; Swanson, Patrick C

    2009-03-24

    V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-ACAAAAACC) motifs separated by either 12- or 23-base pairs of poorly conserved sequence. The high mobility group proteins HMGB1 and HMGB2 (HMGB1/2) are highly abundant architectural DNA binding proteins known to promote RAG-mediated synapsis and cleavage of consensus recombination signals in vitro by facilitating RSS binding and bending by the RAG1/2 complex. HMGB1/2 are known to recognize distorted DNA structures such as four-way junctions, and damaged or modified DNA. Whether HMGB1/2 can promote RAG-mediated DNA cleavage at sites lacking a canonical RSS by targeting or stabilizing structural distortions is unclear, but is important for understanding the etiology of chromosomal translocations involving antigen receptor genes and proto-oncogene sequences that do not contain an obvious RSS-like element. Here we identify a novel DNA breakpoint site in the plasmid V(D)J recombination substrate pGG49 (bps6197) that is cleaved by the RAG proteins via a nick-hairpin mechanism. The bps6197 sequence lacks a recognizable heptamer at the breakpoint (5'-CCTGACG-3') but contains a nonamer-like element (5'-ACATTAACC-3') 30 base pairs from the cleavage site. We find that RAG-mediated bps6197 cleavage is promoted by HMGB1/2, requiring both HMG-box domains to be intact to facilitate RAG-mediated cleavage, and is stimulated by synapsis with a 12-RSS. A dyad-symmetric inverted repeat sequence lying 5' to the breakpoint is implicated as a target for HMGB1/2 activity. We have identified a novel DNA sequence, called bps6197, that supports standard V(D)J-type cleavage despite the absence of an apparent heptamer motif. Efficient RAG-mediated bps6197 cleavage requires the presence of HMGB1/2, is stimulated by synapsis with a 12-RSS partner, and is directed in part by an inverted repeat sequence adjacent to the DNA cleavage site. These results have important implications for understanding how the RAG proteins can introduce a DNA double-strand break at DNA sequences that do not contain an obvious heptamer-like motif.

  12. SURVEY

    DEFF Research Database (Denmark)

    SURVEY er en udbredt metode og benyttes inden for bl.a. samfundsvidenskab, humaniora, psykologi og sundhedsforskning. Også uden for forskningsverdenen er der mange organisationer som f.eks. konsulentfirmaer og offentlige institutioner samt marketingsafdelinger i private virksomheder, der arbejder...... med surveys. Denne bog gennemgår alle surveyarbejdets faser og giver en praktisk indføring i: • design af undersøgelsen og udvælgelse af stikprøver, • formulering af spørgeskemaer samt indsamling og kodning af data, • metoder til at analysere resultaterne...

  13. Sporothrix schenckii (sensu strict S. globosa) mating type 1-2 (MAT1-2) gene.

    Science.gov (United States)

    Kano, Rui; Anzawa, Kazushi; Mochizuki, Takashi; Nishimoto, Katsutaro; Hiruma, Masataro; Kamata, Hiroshi; Hasegawa, Atsuhiko

    2013-09-01

    Sporotix schenckii is a pathogenic fungus that causes human and animal sporotrichosis, and based on morphology of the sessile conidia and molecular analysis, it was recently recognized as a species complex comprising at least the following six sibling species: S. albicans, S. brasiliensis, S. globosa, S. luriei, S. mexicana and S. schenckii. However, apart from S. schenckii sensu strict, only S. brasiliensis, S. globosa and S. luriei are associated with human and animal infection. S. globosa has been most commonly isolated in Asia, Europe and the USA; therefore, molecular epidemiological study for S. globosa is important in relation to human sporotrichosis in Japan. To the best of our knowledge, this is the first study to determine the mating type 1-2 (MAT1-2) gene of Sporothrix schenckii with the aim of understanding the taxonomy of the genus Sporothrix. The MAT1-2 gene (1618 bp) encodes a protein sequence of 198 amino acids. Reverse transcription polymerase chain reaction analysis also detected MAT1-2 gene mRNA expression in all of the S. schenckii strains examined, indicating that this gene is expressed in S. schenckii cells. Phylogenetic analysis of the MAT1-2 gene fragments of Ophiostoma himal-ulmi, O. novo-ulmi, O. ulmi and S. schenckii indicated that these isolates could be classified into four clusters. MAT1-1 gene-specific polymerase chain reaction was positive in 15 isolates, but negative in four human isolates and one feline isolate.

  14. Some notes on writing a commentary: Isaiah 1-12

    Directory of Open Access Journals (Sweden)

    A. Groenewald

    2009-07-01

    Full Text Available I was requested by the editors of the �Historical Commentary on the Old Testament� (HCOT to contribute two volumes on Isaiah in this series. This present article, however, focuses only on volume I: Isaiah 1-12. The aim of this article can be summarised in six points. Some introductory remarks are made with regard to the genre of commentary writing. Secondly, the viewpoint of the HCOT series is outlined; in other words its methodological and epistemological viewpoint. Thirdly, recent developments in the study of the book of Isaiah are discussed. Fourthly, my own objectives and hypothesis with regard to this project are outlined. Fifthly, a short overview of Isaiah 1-12 on a synchronic level is given. Sixthly, my research methodology is defined as a �diachronically reflected synchronic� reading of the Isaianic text. In the last section some concluding remarks are made.

  15. Beam current transformer (BCT) for experiment WA1/2

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    In experiment WA1/2, a 400 GeV proton beam from the SPS was directed at a target, downstream of which a hadron line selected, in several narrow momentum bands, a beam of either pi+ and K+ or pi- and K-. These neutrino-parent particles, before entering a 292 m long decay tunnel, passed through a set of 2 BCTs of a design seen here. They measured the hadron intensity (10^10 to 10^11 particles/pulse) with a precision of the order of 1%. There were 2 of them, for enhanced precision and confidence. After the discovery of neutral currents in the Gargamelle-experiment, WA1/2 was the first follow-up, high-precision experiment (Z.Phys.C35, 443-452, 1987 and Z.Phys.C45, 361-379, 1990). See also 7706516X.

  16. Analyzing ERK 1/2 signalling and targets.

    Science.gov (United States)

    Brietz, Alexandra; Schuch, Kristin Verena; Wangorsch, Gaby; Lorenz, Kristina; Dandekar, Thomas

    2016-07-19

    The ERK cascade (e.g. Raf-1) protects the heart from cell death and ischemic injury but can also turn maladaptive. Furthermore, an additional autophosphorylation of ERK2 at Thr188 (Erk1 at Thr208) allows ERK to phosphorylate nuclear targets involved in hypertrophy, stressing this additional phosphorylation as a promising pharmacological target. An in silico model was assembled and setup to reproduce different phosphorylation states of ERK 1/2 and various types of stimuli (hypertrophic versus non-hypertrophic). Synergistic and antagonistic receptor stimuli can be predicted in a semi-quantitative model, simulated time courses were experimentally validated. Furthermore, we detected new targets of ERK 1/2, which possibly contribute to the development of pathological hypertrophy. In addition we modeled further interaction partners involved in the protective and maladaptive cascade. Experimental validation included different gene expression data sets supporting key components and novel interaction partners as well as time courses in chronic heart failure.

  17. Synthesis and Conformation of cis-1,2-Disubstituted Cyclododecene

    Institute of Scientific and Technical Information of China (English)

    HAN,Xiang-Yu(韩翔宇); WANG,Ming-An(王明安); LIANG,Xiao-Mei(梁晓梅); WANG,Dao-Quan(王道全)

    2004-01-01

    Eight 1,2-disubstituted cyclododecenes were synthesized from a-alkoxycarbonyl-cyclododecanone and alkyl chloroformate. Their configuration and conformation determined by IR, NMR spectroscopy and X-ray diftraction analysis showed that the carbon-carbon double bond of all of the synthesized compounds has cis-configuration, and the ring skeleton of their preferred conformation is [lene2333] in solid, and they may adopt two different [lene2333]conformations, which exist in a dynamic equilibrium in solution.

  18. Studies of the Beetle 1.2 Pipeline Homogeneity

    CERN Document Server

    Agari, M; Blouw, J; Schmelling, M; Hofmann, W; Schwingenheuer, B; Pugatch, V; Volyanskyy, D; Jiménez-Otero, S; Tran, M T; Voss, H; Bernhard, R P; Köstner, S; Lehner, F; Lois, C; Needham, M; Steinkamp, O; Straumann, U; Vollhardt, A

    2003-01-01

    The pipeline homogeneity in general and the behaviour of the edge channels of the Beetle 1.2 readout chip [1] were studied with data taken during the Silicon Tracker test beam period in May 2003. A contribution of roughly 10\\% from pipeline inhomogeneities to the strip noise was observed. All channels including the first and the last one were found to be fully functional.

  19. General synthesis of substituted 1,2-dihydropyridines.

    Science.gov (United States)

    Tejedor, David; Cotos, Leandro; Méndez-Abt, Gabriela; García-Tellado, Fernando

    2014-11-07

    A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.

  20. Wheeler-Feynman dynamics of spin-1/2 particles

    Energy Technology Data Exchange (ETDEWEB)

    Van Alstine, P.; Crater, H.W.

    1986-02-15

    By combining a supersymmetric description of a spinning particle in an external field with an appropriate modification of the ''adjunct field'' of Wheeler and Feynman, we construct a many-time relativistic dynamics for arbitrary numbers of spin-(1/2) and spinless particles in mutual scalar or vector interaction. Quantization of the slow-motion approximation to the dynamics of two spinning particles reproduces the corresponding field-theoretic (Bethe-Salpeter) dynamics through order U.

  1. Wheeler-Feynman dynamics of spin-1/2 particles

    Science.gov (United States)

    van Alstine, Peter; Crater, Horace W.

    1986-02-01

    By combining a supersymmetric description of a spinning particle in an external field with an appropriate modification of the ``adjunct field'' of Wheeler and Feynman, we construct a many-time relativistic dynamics for arbitrary numbers of spin-(1/2) and spinless particles in mutual scalar or vector interaction. Quantization of the slow-motion approximation to the dynamics of two spinning particles reproduces the corresponding field-theoretic (Bethe-Salpeter) dynamics through order α4.

  2. CMMI (Trademark) for Acquisition, Version 1.2

    Science.gov (United States)

    2007-11-01

    or established technologies to be applied, such as robotics, composite materials, or artificial intelligence ; and breadth of the functionality...you to align the way you do busines They allow you to address scalability and provide a way to incorpora knowledge of how to do things better. Processes...part by the selections made by the organization to meet its busine objectives. Tying It All Together 38 CMMI for Acquisition Version 1.2 4

  3. Hydrophilic nanoporous polystyrenes and 1,2-polybutadienes

    DEFF Research Database (Denmark)

    Guo, Fengxiao; Jankova Atanasova, Katja; Vigild, Martin Etchells;

    2008-01-01

    Nanoporous polymers from ordered block copolymers having hydrophilic cavity surfaces were successfully prepared by two methodologies: ' 1. Nanoporous polystyrenes fromPtBA-b-PS diblock or PDMS-b-PtBA-b-PS triblock copolymer precursors by atom transfer radical polymerization (ATRP), or combination...... different pathways for the conversion of the double bonds of 1,2-PB to bromoisobutyrate by using one to three steps chemical modification. Grafting polyacrylate layers of PPEGMA, PHEMA etc. onto themon...

  4. Isomerization and fragmentation pathways of 1,2-azaborine.

    Science.gov (United States)

    Edel, Klara; Fink, Reinhold F; Bettinger, Holger F

    2016-01-05

    The generation of 1,2-azaborine (4), the BN-analogue of ortho-benzyne, was recently achieved by elimination of tert-butyldimethylchlorosilane under the conditions of flash vacuum pyrolysis. The present investigation identifies by computational means pathways for the thermal isomerization and fragmentation of 1,2-azaborine. The computations were performed using single reference (hybrid/density functional, second order Møller-Plesset perturbation, and coupled cluster theories) as well as multiconfiguration methods (complete active space SCF based second order perturbation theory, multireference configuration interaction, and multiconfiguration coupled electron pair approximation) with basis sets up to polarized triple-ζ quality. The 1,2-azaborine is, despite the distortion of its molecular structure, the most stable C4H4BN isomer investigated. The formation of BN-endiyne isomers is highly unfavorable as the identified pathways involve barriers close to 80 kcal mol(-1). The concerted fragmentation to ethyne and 2-aza-3-bora-butadiyne even has a barrier close to 120 kcal mol(-1). The fragmentation of BN-enediynes has energetic requirements similar to enediynes. © 2015 Wiley Periodicals, Inc.

  5. 1,2-dicarbonyl compounds in commonly consumed foods.

    Science.gov (United States)

    Degen, Julia; Hellwig, Michael; Henle, Thomas

    2012-07-18

    1,2-Dicarbonyl compounds, formed from carbohydrates during thermal processing in the course of caramelization and Maillard reactions, are intensively discussed as precursors for advanced glycation endproducts in foods and in vivo. To obtain information about the uptake of individual compounds with commonly consumed foods, a comprehensive analysis of the content of 3-deoxyglucosone (3-DG), 3-deoxygalactosone (3-DGal), and methylglyoxal (MGO) together with 5-hydroxymethylfurfural (HMF) in 173 food items like bakery products, pasta, nonalcoholic and alcoholic beverages, sweet spreads, and condiments was performed. Following suitable cleanup procedures, 1,2-dicarbonyl compounds were quantitated after derivatization with o-phenylenediamine via RP-HPLC with UV detection. 3-DG proved to be the predominant 1,2-dicarbonyl compound with concentrations up to 410 mg/L in fruit juices, 2622 mg/L in balsamic vinegars, and 385 mg/kg in cookies, thus exceeding the corresponding concentrations of HMF. 3-DGal was found to be of relevance in many foods even in the absence of galactose. MGO was only of minor quantitative importance in all foods studied, except for manuka honey. Dietary intake was estimated to range between 20 and 160 mg/day for 3-DG and 5 and 20 mg/day for MGO, respectively.

  6. Water Security Toolkit User Manual Version 1.2.

    Energy Technology Data Exchange (ETDEWEB)

    Klise, Katherine A.; Siirola, John Daniel; Hart, David; Hart, William Eugene; Phillips, Cynthia Ann; Haxton, Terranna; Murray, Regan; Janke, Robert; Taxon, Thomas; Laird, Carl; Seth, Arpan; Hackebeil, Gabriel; McGee, Shawn; Mann, Angelica

    2014-08-01

    . ii Acknowledgements This work was supported by the U.S. Environmental Protection Agency through its Office of Research and Development (Interagency Agreement # DW8992192801). The material in this document has been subject to technical and policy review by the U.S. EPA, and approved for publication. The views expressed by individual authors, however, are their own, and do not necessarily reflect those of the U.S. Environmental Protection Agency. Mention of trade names, products, or services does not convey official U.S. EPA approval, endorsement, or recommendation. The Water Security Toolkit is an extension of the Threat Ensemble Vulnerability Assessment-Sensor Place- ment Optimization Tool (TEVA-SPOT), which was also developed with funding from the U.S. Environ- mental Protection Agency through its Office of Research and Development (Interagency Agreement # DW8992192801). The authors acknowledge the following individuals for their contributions to the devel- opment of TEVA-SPOT: Jonathan Berry (Sandia National Laboratories), Erik Boman (Sandia National Laboratories), Lee Ann Riesen (Sandia National Laboratories), James Uber (University of Cincinnati), and Jean-Paul Watson (Sandia National Laboratories). iii Acronyms ATUS American Time-Use Survey BLAS Basic linear algebra sub-routines CFU Colony-forming unit CVAR Conditional value at risk CWS Contamination warning system EA Evolutionary algorithm EDS Event detection system EPA U.S. Environmental Protection Agency EC Extent of Contamination ERD EPANET results database file GLPK GNU Linear Programming Kit GRASP Greedy randomized adaptive sampling process HEX Hexadecimal HTML HyperText markup language INP EPANET input file LP Linear program MC Mass consumed MILP Mixed integer linear program MIP Mixed integer program MSX Multi-species extension for EPANET NFD Number of failed detections NS Number of sensors NZD Non-zero demand PD Population dosed PE Population exposed PK Population killed TAI Threat assessment input file

  7. Electrical and magnetic properties of (BiNa)1/2(FeV)1/2O3

    Indian Academy of Sciences (India)

    S K Bera; Subrat K Barik; R N P Choudhary; P K Bajpai

    2012-02-01

    Potential multiferroic material, (BiNa)1/2(FeV)1/2O3, synthesized using solid-state route is investigated. The phase formation was confirmed by X-ray diffraction and surface morphology by scanning electron microscopy (SEM). Structural data reveal the single phase formation corroborated by SEM. The grain distribution is uniform with an average grain size of 3.6 m. Electrical properties were investigated in a frequency range (1 kHz–1 MHz) by complex impedance spectroscopy (CIS) technique. The material showed negative temperature coefficient of resistance (NTCR) reflecting semiconductor behaviour. A.C. conductivity was found to obey Johnscher’s law. Conductivity mechanism is discussed and activation energy estimated (1.17 eV) for the conduction process is associated with Fe3+ → Fe2+ variable state. The M–H curve showed the presence of ferromagnetism in the studied material.

  8. The electrical properties and relaxation behavior of AgNb1/2Ta1/2O3 ceramic

    Science.gov (United States)

    Prasad, K. Ganga; Niranjan, Manish K.; Asthana, Saket

    2017-02-01

    Polycrystalline AgNb1/2Ta1/2O3 powder was prepared by solid state reaction method. Preliminary x-ray diffractogram analysis of some aspects of crystal structure showed that a single phase compound formed exhibiting a monoclinic system. Impedance spectroscopy showed the presence of both bulk and grain boundary effects in the material. The relaxation behavior was studied by fitting electric modulus with Bergman function confirms us the existence of non-Debye type of relaxation the material. The ac conductivity spectrum obeyed Funke's double power law and fitting in results, the hopping parameters n1,n2 were indicating the existence of small and large range polaron hopping in the material. The band gap of the material 3.02 eV measured by using UV visible spectroscopy.

  9. [N,N-Bis(2-aminoethylethane-1,2-diamine](ethane-1,2-diaminenickel(II thiosulfate trihydrate

    Directory of Open Access Journals (Sweden)

    Beatrix Seidlhofer

    2012-02-01

    Full Text Available The title compound, [Ni(C2H8N2(C6H18N4]S2O3·3H2O, was accidentally synthesized under solvothermal conditions applying [Ni(en3]Cl2 (en is ethane-1,2-diamine as the Ni source. The asymmetric unit consists of one discrete [Ni(tren(en]2+ complex [tren is N,N-bis(2-aminoethylethane-1,2-diamine] in which the Ni2+ cation is sixfold coordinated within a slightly distorted octahedron, one thiosulfate anion and three water molecules. In the crystal, the complex cations, anions and water molecules are linked by an intricate hydrogen-bonding network. One C atom of the tren ligand, as well as one O atom of a water molecule, are disordered over two sites and were refined using a split model (occupancy ratios = 0.85:15 and 0.60:0.40, respectively.

  10. China's imports Up 15 Percent in 2002

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Based on the latest statistical figure released from China Customs, China's total imports rose 15 percent in 2002 as compared to the previous year. The spending for China's crude oil import rose 9.4 percent to 12.757 billion yuan in 2002 while the importing volume of oil products dropped 4.9 percent to 20.34

  11. Guidance on Compatibility of UST Systems with Ethanol Blends Greater Than 10 Percent and Biodiesel Blends Greater Than 20 Percent

    Science.gov (United States)

    EPA guidance on complying with the federal compatibility requirement for underground storage tank (UST) systems storing gasoline containing greater than 10 percent ethanol or diesel containing greater than 20 percent biodiesel.

  12. QCD corrections to inclusive $\\Delta S=1,2$ transitions

    OpenAIRE

    Jamin, Matthias

    1994-01-01

    The talk summarises a calculation of the two-point functions for $\\Delta S=1$ current-current and QCD-penguin operators, as well as for the $\\Delta S=2$ operator, at the next-to-leading order. The size of the gluonic corrections to current-current operators is large, providing a qualitative understanding of the observed enhancement in $\\Delta I=1/2$ transitions. In the $\\Delta S=2$ sector the QCD corrections are quite moderate ($\\approx -20\\%$). This work has been done in collaboration with A...

  13. Proper Time for Spin 1/2 Particles

    CERN Document Server

    Kudaka, S; Kudaka, Shoju; Matsumoto, Shuichi

    2005-01-01

    We find a quantum mechanical formulation of proper time for spin 1/2 particles within the framework of the Dirac theory. It is shown that the rate of proper time can be represented by an operator called the ` ` tempo operator'', and that the proper time itself be given by the integral of the expectation value of the operator. The tempo operator has some terms involving the Pauli spin matrices, and the evolution of the proper time is influenced by the spin state via these terms. The relation between the tempo operator and the metric tensor is elucidated.

  14. Rectangular Polyomino Set Weak (1,2)-achievement Games

    CERN Document Server

    Fisher, Edgar

    2010-01-01

    In a polyomino set (1,2)-achievement game the maker and the breaker alternately mark one and two previously unmarked cells respectively. The maker's goal is to mark a set of cells congruent to one of a given set of polyominoes. The breaker tries to prevent the maker from achieving his goal. The teams of polyominoes for which the maker has a winning strategy is determined up to size 4. In set achievement games, it is natural to study infinitely large polyominoes. This enables the construction of super winners that characterize all winning teams up to a certain size.

  15. MAMBO 1.2mm observations of luminous starbursts at z~2 in the SWIRE fields

    CERN Document Server

    Lonsdale, C J; Omont, A; Shupe, D; Berta, S; Zylka, R; Siana, B; Lutz, D; Farrah, D; Smith, H E; Lagache, G; De Breuck, C; Owen, F; Beelen, A; Weedman, D; Franceschini, A; Clements, D; Tacconi, L; Afonso-Luis, A; Pérez-Fournon, I; Cox, P; Bertoldi, F

    2008-01-01

    We report on--off pointed MAMBO observations at 1.2 mm of 61 Spitzer-selected star-forming galaxies from the SWIRE survey. The sources are selected on the basis of bright 24um fluxes (f_24um>0.4mJy) and of stellar dominated near-infrared spectral energy distributions in order to favor z~2 starburst galaxies. The average 1.2mm flux for the whole sample is 1.5+/-0.2 mJy. Our analysis focuses on 29 sources in the Lockman Hole field where the average 1.2mm flux (1.9+/-0.3 mJy) is higher than in other fields (1.1+/-0.2 mJy). The analysis of the sources multi-wavelength spectral energy distributions indicates that they are starburst galaxies with far-infrared luminosities ~10^12-10^13.3 Lsun, and stellar masses of ~0.2-6 x10^11 M_sun. Compared to sub-millimeter selected galaxies (SMGs), the SWIRE-MAMBO sources are among those with the largest 24um/millimeter flux ratios. The origin of such large ratios is investigated by comparing the average mid-infrared spectra and the stacked far-infrared spectral energy distrib...

  16. Global Oil and Gas Exploration and Development Expenditure in 2003 Rises 4.8 Percent as Compared to Previous Year

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    A recent survey by Friedman Billings Ramsey (FBR) shows that the oil and gas companies worldwide plan to increase the fund for exploration and development to US$136 billion in 2003, 4.8 percent up from the previous year. The second half of 2003 will see even a higher increase in the fund. In 2002, the exploration and development expenditure of the surveyed oil and gas companies rose 3.6 percent as compared to 2001.

  17. Pharmacokinetics of Malonato (1,2 diaminocyclohexane) platinum.

    Science.gov (United States)

    Kelsen, D P; Ribaud, P; Alcock, N; Burchenal, J H; Young, C W; Mathe, G

    1981-01-01

    Malonato-(1,2 diaminocyclohexane) platinum (MP) is a new platinum analog currently undergoing phase I clinical trials. Using flameless atomic absorption spectrophotometry, the pharmacokinetics of MP were studied at five dosage levels. The drug was given as a prolonged intravenous infusion, lasting from 6 to 24 hours. Peak plasma platinum concentrations (Pt) were seen at the end of the infusion, and ranged from 1.1 microgram/ml when 3 mg/kg was given to 14-20.5 micrograms/ml at the 24-mg/kg level. Following completion of the infusion, a prolonged T1/2 beta (mean 63.5 hours) was noted. The percentage of free:total platinum was high (90-95%) at the beginning of the infusion but fell rapidly, to only 15-21% at the end of the 24-hour infusions. Urinary excretion accounted for 16-37.5% of the total administered dose. MP appears to have several pharmacokinetic features in common with cisplatin: rapid binding to protein, a prolonged terminal phase half-life involving primarily bound platinum, and incomplete excretion by the kidney.

  18. LBNF 1.2 MW TARGET: CONCEPTUAL DESIGN & FABRICATION

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, Cory F. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-29

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  19. Enthalpy and Heat Capacity Data for 1,2-Cyclohexanediol

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 章亚东; 蒋登高

    2003-01-01

    The thermodynamic properties of different geometric structures of 1,2-cyclohexanediol which were rarely reported in literature, such as combustion enthalpy, formation enthalpy, melting enthalpy and heat capacities, were determined by NETZSCH DSC 204 Scanning Calorimeter. The relationship between the melting point and the composition for the mixture system of cis-l,2-cyclohexanediol and trans-l,2-cyclohexanediol was investigated and corresponding phase diagram was obtained. "The melting enthalpies of both cis-l,2-cyclohexanediol and trans-l,2-cyclohexanediol are 20.265 kJ·mo1-1 and 16.368 kJ·mo1-1 respectively. The standard combustion enthalpies of cis- and trans-l,2-cyclohexaneddiol were determined by calorimeter. They are respectively -3507.043kJ·mo1-1 and -3497.8kJ·mo1-1 at 298.15 K.The standard formation enthalpies are respectively 568.997kJ·mol-1 and 578.240kJ·mol-1 for cis- and trans-1,2-cyclohexaneddiol.

  20. Mechanical behavior of the directionally solidified. gamma. /. gamma. '--delta eutectic alloy. [Ni-20. 0 percent Nb-2. 5 percent Al-6. 0 percent Cr

    Energy Technology Data Exchange (ETDEWEB)

    Barkalow, R.H.; Jackson, J.J.; Gell, M.; Leverant, G.R.

    1975-01-01

    The eutectic alloy Ni-20.0 percent Nb-2.5 percent Al-6.0 percent Cr was tested in short-term creep and long-term exposure to service conditions to assess its suitability for high temperature turbine blade applications. Long-time exposure showed the lamellar microstructure of the alloy to be exceptionally stable. Other properties tested were notch sensitivity, isothermal and thermomechanical fatigue strength, shear strength, and transverse ductility. It was shown that this alloy is superior to the best currently available directionally solidified superalloys over the temperature/stress conditions encountered in turbine airfoils.

  1. ERF1 -- Enhanced River Reach File 1.2

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — U.S. Environmental Protection Agency's River Reach File 1 (RF1)to ensure the hydrologic integrity of the digital reach traces and to quantify the mean water time of...

  2. Urinary prothrombin fragment 1+2 in patients with venous thrombosis and myocardial infarction

    NARCIS (Netherlands)

    Van Es, J.; Biere-Rafi, S.; Ahdi, M.; Kamphuisen, P.W.; Meijers, J.C.M.; Gerdes, V.E.A.

    2013-01-01

    Patients with venous-thromboembolism (VTE) and myocardial infarction (MI) have elevated prothrombin fragment 1+2 (F1+2) levels. In patients with postoperative VTE, urinary F1+2 (uF1+2) was higher than in individuals without VTE. To explore the relationship between plasma and uF1+2 we performed a pil

  3. Implementing a telephone based peer support intervention for women with a BRCA1/2 mutation.

    Science.gov (United States)

    Farrelly, Ashley; White, Victoria; Young, Mary-Anne; Jefford, Michael; Ieropoli, Sandra; Duffy, Jessica; Winship, Ingrid; Meiser, Bettina

    2015-09-01

    Women with a BRCA1/2 gene mutation face complex risk management decisions and communication issues that can lead to increased levels of distress and unmet needs. We describe the implementation of a peer-support program that aims to reduce distress among women with a BRCA1/2 mutation, including peer and support recipient satisfaction with the program, challenges and lessons learnt. Participants with a BRCA1/2 mutation were matched with a trained peer volunteer (also a mutation carrier) to have regular one-on-one phone calls, over 4 months. Details of the calls, including topics discussed, time spent and number, were collected. Peers and recipients completed surveys assessing how they felt the contact went, satisfaction with the program, and preferences for matching. Satisfaction with the program was high for both peers and recipients. 80% of pairs ended contact through mutual agreement. Peers and recipients differed in the importance placed on age and surgery experience to determine matches. The most challenging aspect of the program for peers was difficulty in contacting recipients. Peer support for women with a BRCA1/2 mutation is feasible. However, to encourage continued involvement by peers and recipients greater flexibility in the method and delivery of contact is needed. We advocate the use of text-messaging and/or email as mechanisms for pairs to arrange and maintain contact. These strategies should be in addition to, rather than replacing, calls. A mixed medium intervention, where recipients can tailor the method of communication to suit their needs, may be preferable and effective, though this would need to be tested.

  4. (1RS,2RS,3RS-1,2-Dimethoxy-3-methyl-2-phenyl-1-(2-thienylcyclopropane

    Directory of Open Access Journals (Sweden)

    Laura Torre-Fernández

    2009-04-01

    Full Text Available In the title compound, C16H18O2S, a new cis-1,2-dimethoxycyclopropane, the two methoxy groups are in a cis configuration and in trans positions with respect to the H atom and the phenyl and thienyl rings on the cyclopropyl group. The molecular packing is dominated by weak intermolecular C—H...O interactions, allowing the formation of zigzag chains propagating parallel to the c axis. The dihedral angle between the aromatic rings is 86.12 (8°.

  5. The Stellar Mass Tully-Fisher Relation to z=1.2 from AEGIS

    CERN Document Server

    Kassin, S A; Faber, S M; Koo, D C; Lotz, J M; Diemand, J; Harker, J J; Bundy, K; Metevier, A J; Phillips, A C; Cooper, M C; Croton, D J; Konidaris, N; Noeske, K G; Willmer, C N A; Kassin, Susan A.; Weiner, Benjamin J.; Koo, David C.; Lotz, Jennifer M.; Harker, Justin J.; Bundy, Kevin; Phillips, Andrew C.; Cooper, Michael C.; Croton, Darren J.; Konidaris, Nicholas; Noeske, Kai G.

    2007-01-01

    We combine newly measured rotation velocities, velocity dispersions, and stellar masses to construct stellar mass Tully-Fisher relations (M*TFRs) for 544 galaxies with strong emission lines at 0.1Survey (AEGIS) and the Deep Extragalactic Evolutionary Probe 2 Survey (DEEP2). The conventional M*TFR using only rotation velocity (Vrot) shows large scatter (~1.5 dex in velocity). The scatter and residuals are correlated with morphology in the sense that disturbed, compact, and major merger galaxies have lower velocities for their masses. We construct an M*TFR using the kinematic estimator S_0.5 which is defined as sqrt(0.5Vrot^2 + sigma_g^2) and accounts for disordered or non-circular motions through the gas velocity dispersion (sigma_g). The new M*TFR, termed S_0.5/M*TFR, is remarkably tight over 0.1

  6. Green synthesis and characterization of Ag1/2Al1/2TiO3 nanoceramics

    Directory of Open Access Journals (Sweden)

    Kumar Sandeep

    2015-03-01

    Full Text Available Single phase silver aluminum titanate (Ag1/2Al1/2TiO3, later called AAT, nanoceramic powder (particle size 2 to 7.5 nm was synthesized by a low-cost, green and reproducible tartaric acid gel process. X-ray, FT-IR, energy dispersive X-ray and high resolution transmission electron microscopy analyses were performed to ascertain the formation of AAT nanoceramics. X-ray diffraction data analysis indicated the formation of monoclinic structure having the space group P2/m(10. UV-Vis study revealed the surface plasmon resonance at 296 nm. Dielectric study revealed that AAT nanoceramics could be a suitable candidate for capacitor applications and meets the specifications for “Z7R” of Class I dielectrics of Electronic Industries Association. Complex impedance analyses suggested the dielectric relaxation to be of non-Debye type. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were performed using the impedance data. Electric modulus studies supported the hopping type of conduction in AAT. The correlated barrier hopping model was employed to successfully explain the mechanism of charge transport in AAT. The ac conductivity data were used to evaluate the density of states at Fermi level and minimum hopping length of the compound.

  7. Características de Carcaça e da Carne de Novilhos Filhos de Vacas 1/2 Nelore 1/2 Charolês e 1/2 Charolês 1/2 Nelore Acasaladas com Touros Charolês ou Nelore Carcass and Meat Characteristics of Steers Produced by 1/2 Nellore 1/2 Charolais and 1/2 Charolais 1/2 Nellore Cows Mated with Charolais and Nellore Bulls

    Directory of Open Access Journals (Sweden)

    Fabiano Nunes Vaz

    2002-07-01

    Full Text Available Este experimento foi conduzido com o objetivo de avaliar o efeito do cruzamento entre vacas 1/2 Nelore 1/2 Charolês com touros Charolês e 1/2 Charolês 1/2 Nelore com touros Nelore, sobre as características de carcaça e da carne de novilhos oriundos desses acasalamentos, abatidos aos dois anos de idade. Foram utilizados 80 novilhos 3/4 Nelore (N 1/4 Charolês (C e 136 novilhos 3/4 C 1/4 N. Os dados foram coletados de setembro de 1986 a dezembro de 1998. O modelo estatístico utilizado incluiu os efeitos classificatórios de grupo contemporâneo, idade da vaca e composição racial, bem como o efeito da idade do animal ao abate como covariável. Os novilhos 3/4 C 1/4 N foram superiores em peso de fazenda (468 contra 448 kg, conformação de carcaça (11,3 contra 10,4 pontos, porcentagem de músculo (66,9 contra 64,8%, área de Longissimus dorsi (69,5 contra 64,7 cm², área de Longissimus dorsi ajustada para o peso de carcaça fria (27,9 contra 26,6 cm², comprimento de carcaça (126 contra 123 cm, perímetro de braço (36,5 contra 35,4 cm e maciez da carne (6,50 contra 5,20 pontos, enquanto os 3/4 N 1/4 C apresentaram maiores rendimento de carcaça (54,6 contra 53,7%, comprimento de perna (74,0 contra 72,0 cm e de braço (41,5 contra 39,7 cm, espessura de gordura subcutânea (3,29 contra 2,70 mm e porcentagem de gordura na carcaça (19,5 contra 17,8%. Não foi verificada diferença significativa para peso de carcaça fria, cor, textura, marmoreio, palatabilidade e suculência da carne.The objective of the experiment was to evaluate the carcass and meat characteristics of two year old steers, produced by the mating of 1/2 Nellore 1/2 Charolais cows with Charolais bulls and by mating 1/2 Charolais 1/2 Nellore cows with Nellore bulls. Eighty 3/4 Nellore 1/4 Charolais (NC and 136 3/4 Charolais 1/4 Nellore steers were used. The data were collected from September 1986 to December 1998. In the statistical model were included the contemporary group effect, age of dam at calving and genetic group as class variable and age of steer in days at slaughter as covariable. 3/4 C 1/4 N steers were heavier in slaughter weight (468 vs. 448 kg, carcass conformation (11.3 vs. 10.4 points, muscle percentage (66.9 vs. 64.7%, Longissimus dorsi area (69.5 vs. 64.7 cm², Longissimus dorsi area adjusted for 100 kg of cold carcass weight (27.9 vs. 26.6 cm², carcass length (126 vs. 123 cm, arm perimeter (36.5 vs. 35.4 cm and meat tenderness (6.50 vs. 5.20 points, while 3/4 N 1/4 C steers showed higher dressing percentage (54.6 vs. 53.7%, leg length (74.0 vs. 72.0 cm, arm length (41.5 vs. 39.7 cm, subcutaneous fat thickness (3.29 vs. 2.70 mm and fat percentage (19.5 vs. 17.8%. No significant difference was observed for cold carcass weight, meat color, texture, marbling, flavor and juiciness.

  8. 反序律B{1,2,i}A{1,2,i}=(AB){1,2,i}i=3,4成立的充要条件%Necessary and sufficient conditions for reverse order laws B{1,2,i}A { 1,2,i} (∈)(AB){1,2,i},i=3,4

    Institute of Scientific and Technical Information of China (English)

    孙萍; 孟令胜

    2011-01-01

    证明两个矩阵乘积的{1,2,3}-逆和{1,2,4}-逆反序律包含关系B{1,2,i}A{1,2,i}(∈)(AB){1,2,i},i=3,4分别等价干等式反序律B{1,2,i}A{1,2,i}=(AB){1,2,i},i=3,4.从而得到上述等式反序律成立的充要条件.%It was verified that the inclusion relationship B{1,2,i}A{1,2,i} (∈)(AB){1,2,i}, i= 3,4 for reverse order laws of {1,2,3}-inverse and {1,2,4}- inverse of the product of two matrixes was respectively equivalent to the identical reverse order laws B{1,2,i}A{1,2,i}=(AB){1,2,i}, i=3,4, so that the necessary and sufficient conditions were obtained for holding the foregoing identical reverse order laws.

  9. Fabry-Perot Observations of HH 1/2

    Directory of Open Access Journals (Sweden)

    A. Riera

    2005-01-01

    Full Text Available Presentamos nuevas observaciones Fabry-Perot del sistema HH1/2 en la l nea de H. Se han obtenidos los perfiles de las l neas, y los mapas de velocidad radial y de dispersi n de velocidades a partir de los canales de velocidad de los objetos HH 1 y HH 2. La distribuci on espacial de la velocidad radial de ambos objetos (HH 1, HH 2 presenta material desplazado al rojo hacia la fuente, y material desplazado al azul alej ndose de la fuente. Un modelo que contempla la presencia de emisi n directa+dispersada con tres condensaciones emisoras reproduce cualitativamente la distribuci n espacial de la velocidad radial y de la dispersi n de velocidades de HH 2.

  10. sl(1|2) Super-Toda Fields

    Institute of Scientific and Technical Information of China (English)

    YANG Zhan-Ying; XUE Pan-Pan; ZHAO Liu; SHI Kang-Jie

    2008-01-01

    Explicit exact solution of supersymmetric Toda fields associated with the Lie superalgebra sr(2|1) is con-structed. The approach used is a super extension of Leznov-Saveliev algebraic analysis, which is based on a pair of chiral and antichiral Drienfeld-Sokolov systems. Though such approach is well understood for Toda field theories associated with ordinary Lie algebras, its super analogue was only successful in the super Liouville case with the underlying Lie superalgebra osp(1|2). The problem lies in that a key step in the construction makes use of the tensor product decom-position of the highest weight representations of the underlying Lie superalgebra, which is not clear until recently. So our construction made in this paper presents a first explicit example of Leznov-Saveliev analysis for super Toda systems associated with underlying Lie superalgebras of the rank higher than 1.

  11. Conformation of 1,2-Dimethoxyethane in Water

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To understand the conformation of 1,2-dimethoxyethane (DME) in water, a system of two kinds of molecules, DME and H2O, was focused. The interaction of various conformers of DME with water was studied by means of ab initio molecular orbital calculation with 6-31G(d)basis set. It is shown that there are two forms of interactions between the two molecules in the sys tem, the close touched (H2O attaches to the two oxygen atoms of DME) and the open touched (H2O attaches to one oxygen atom of DME) structures. The conformation of DME is remark ably influenced by the interactions. Instead the ttt conformer is preferred in the gas state, with a close touched H2O the tgt conformer becomes the most stable one. The obtained hydration ener gies show that the stabilized order of DME conformers by water is tgt>tgg'>ttt.

  12. Vacuum polarization in $d+{1/2}$ dimensions

    CERN Document Server

    Fosco, C D; Roditi, I

    2004-01-01

    We study the main properties of the one-loop vacuum polarization function ($\\Pi_{\\alpha \\beta}$) for spinor $QED$ in `$d + {1/2}$ dimensions', i.e., with fields defined on ${\\mathcal M} \\subset {\\mathbb R}^{d+1}$ such that ${\\mathcal M} = \\{(x_0,...,x_d) | x_{d}\\geq 0 \\}$, with bag-like boundary conditions on the boundary $\\partial{\\mathcal M} = \\{(x_0,...,x_d) | x_{d}= 0 \\}$. We obtain an exact expression for the induced current due to an external constant electric field normal to the boundary. We show that, for the particular case of 2+1 dimensions, there is a transverse component for the induced current, which is localized on a region close to $\\partial{\\mathcal M}$. This current is a parity breaking effect purely due to the boundary.

  13. Generalized Spin-1/2 Operators and their Eigenvectors

    CERN Document Server

    Mweene, H V

    1999-01-01

    Recently, we have shown how the interpretation of quantum mechanics due to Lande' can be used to derive from first principles generalized formulas for the operators and some eigenvectors for spin 1/2. Though we gave the operators for all the components of the spin, we did not give the eigenvectors of the operators for the x and y components. We now give these eigenvectors. In addition, we present a new and simple method for deriving the operators for the x and y components of the spin as well as their eigenvectors from the corresponding quantities for the z component. We give a general proof that the operator for the square of the spin is the unit matrix multiplied by the value of the square of the spin.

  14. Effects of Four Week Body Building Training on Under Skin Fat Percent if Non-Athlete Female Students

    Directory of Open Access Journals (Sweden)

    Amineh Sahranavard Gargari

    2011-09-01

    Full Text Available The aim of this study is to study the effect of a training program using weight on under skin fat percent in various body parts of female students of Islamic Azad university of Shabestar. Among 70 students, 40 who had physical education 1,2 course aging 18 to 25 were selected. They were all physically healthy. Using Caliper Under skin fat thickness in areas triceps, Abdomen, femur was measured and categorized using age based woman fat percent estimation table. Average of three times measuring before and after training program was calculated as fat percent using "Raven". Training program by weight consisted of 4 week each containing 3 sessions of 45 min. Results revealed that although most of samples had Lost weight, under skin fat percent before and after program showed significant difference of p<10% yet training program by weight for weight control has been more effective than weight loss.

  15. Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives

    Directory of Open Access Journals (Sweden)

    Chandani Patel

    2016-06-01

    Full Text Available A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1–9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone sulfonyl chlorides 10–18. These were converted to the dibromo compounds 19–27 through reaction with bromine in glacial acetic acid. Compounds 19–27 were reacted with ammonia, methylamine, ethylamine, aniline and benzylamine to generate a library of 45 1,2-benzothiazines 28–72. Compounds 28–72 were evaluated for their antimicrobial activity using broth microdilution techniques against two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus and two Gram-negative bacteria (Proteus vulgaris and Salmonella typhimurium. The results demonstrated that none of the compounds showed any activity against Gram-negative bacteria P. vulgaris and S. typhimurium; however, compounds 31, 33, 38, 43, 45, 50, 53, 55, 58, 60, 63 and 68 showed activity against Gram-positive bacteria Bacillus subtilis and Staphylococcous aureus. The range of minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC was 25–600 µg/mL, though some of the MIC and MBC concentrations were high, indicating weak activity. Structure activity relationship studies revealed that the compounds with a hydrogen atom or an ethyl group on the nitrogen of the thiazine ring exerted antibacterial activity against Gram-positive bacteria. The results also showed that the compounds where the benzene ring of the benzoyl moiety contained a methyl group or a chlorine or bromine atom in the para position showed higher antimicrobial activity. Similar influences were identified where either a bromine or chlorine atom was in the meta position.

  16. CRED Cumulative Map of Percent Scleractinian Coral Cover at Zealandia

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  17. CRED Cumulative Map of Percent Scleractinian Coral Cover at Maug

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  18. CRED Cumulative Map of Percent Scleractinian Coral Cover at Tutuila

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  19. CRED Cumulative Map of Percent Scleractinian Coral Cover at Guguan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  20. CRED Cumulative Map of Percent Scleractinian Coral Cover at Arakane

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  1. CRED Cumulative Map of Percent Scleractinian Coral Cover at Saipan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  2. CRED Cumulative Map of Percent Scleractinian Coral Cover at Sarigan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  3. CRED Cumulative Map of Percent Scleractinian Coral Cover at Agrihan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  4. CRED Cumulative Map of Percent Scleractinian Coral Cover at Anatahan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This map displays optical validation observation locations and percent coverage of scleractinian coral overlaid on bathymetry.

  5. GSM(m,1)(m=1,2)模型的数值解%Numeriacl Solution of GSM (m, 1)(m= 1,2)Model

    Institute of Scientific and Technical Information of China (English)

    吴强; 刘炳琪

    2001-01-01

    The prediction accuracy can be improved by using the spline function to correct the residue of GM (m,1)(m=1,2). Numerical Solution of GSM (m,1)(m=1,2)Modle is given.%本文用样条函数对GM(m,1)(m=1,2)模型的残差序列进行插值拟合,得到GSM(m,1)(m=1,2)模型的数值解.

  6. Preliminary site description Simpevarp subarea - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Winberg, Anders (ed.)

    2005-04-01

    The objectives of the version 1.2 site descriptive modelling (SDM) of the Simpevarp subarea are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations on a continuous basis. The modelling work is based on primary data available at the time of the data freeze for Simpevarp 1.2, April 1, 2004. The local scale model area (24 km{sup 2}) for the Simpevarp 1.2 modelling encompasses both the Simpevarp and Laxemar subareas. The local model area is located in the centre of a regional scale model area (273 km{sup 2}). Surface ecosystem models in terms of pools and fluxes of carbon have been developed for the terrestrial (e.g. plants and animals) and limnic (e.g. algae and fish) systems using the Lake Frisksjoen drainage area. Furthermore, a first marine ecosystem model has been developed for the Basin Borholmsfjaerden. Three principal lithological domains have been defined in the subarea, an A domain that is dominated by the Aevroe granite, a domain B that is dominated by the fine-grained dioritoid, a C domain that is characterised by a mixture of of Aevroe granite and quartz monzodiorite. A fourth domain is made up a few scattered domains of diorite to gabbro. In total, 22 deformation zones with high confidence of occurrence have been interpreted in the local scale model area. The understanding of the interpreted deformation zones of the Simpevarp subarea is considered adequate to make a preliminary assessment of available storage volumes for a deep repository. High rock stresses do not appear to be a major concern for the Simpevarp subarea. The magnitude of the maximum principal stress at 500 m in the Simpevarp subarea is estimated at 10-22 MPa. The analysis of the thermal conductivity has developed considerably since Simpevarp 1.1. In terms of interpreted mean values for the identified lithological domains, the thermal conductivity varies within a relatively narrow interval (2.6-2.8 W/(m.K)). The hydraulic properties of the Hydraulic Rock Domains are described in terms of a network of discrete fractures (DFN) with a geometrical description taken from the geological DFN model. A fracture transmissivity distribution is superimposed, and calibrated against existing hydraulic borehole data. Numerical modelling shows that groundwater flow is controlled by topography and the geometry of the system of modelled deformation zones. The modelling also identifies the Simpevarp subarea as an area of groundwater discharge (upward directed flow) at repository depth. Suggested porosities for intact fresh rock (in terms mean values in vol-%) on lithological domain level vary from 0.17 (Fine-grained dioritoid) to 0.40 (Aevroegranite). Suggested formation factors for intact fresh (reflecting diffusion characteristics, mean values) on lithological domain level vary from about 1.0x10{sup -4} (Fine-grained dioritoid) to 2.9x10{sup -4} (Aevroe granite). Important modelling steps have been taken in Simpevarp 1.2 and the main uncertainties are identified, in some cases quantified, or explored as model alternatives. Notwithstanding, some uncertainties still remain unquantified at this stage, and alternative hypotheses are retained only as hypotheses. Additional data, collected in the Simpevarp subarea following the Simpevarp 1.2 data freeze, may allow additional quantification, and may help further reduce the observed uncertainties. For the geological model various possible alternative descriptions are inherent in uncertainties related to geometry, uncertainties in characteristics/properties and confidence of existence of modelled lithological domains and deformations zones. It is obvious that changes to the lithological model have a strong impact on most disciplines (e.g. rock mechanics, thermal and transport properties). The deformation zone model in particular influences the hydrogeological and rock mechanics models. Likewise, there is a strong interdependence between hydrogeology

  7. Preliminary site description Simpevarp subarea - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Winberg, Anders (ed.)

    2005-04-01

    The objectives of the version 1.2 site descriptive modelling (SDM) of the Simpevarp subarea are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations on a continuous basis. The modelling work is based on primary data available at the time of the data freeze for Simpevarp 1.2, April 1, 2004. The local scale model area (24 km{sup 2}) for the Simpevarp 1.2 modelling encompasses both the Simpevarp and Laxemar subareas. The local model area is located in the centre of a regional scale model area (273 km{sup 2}). Surface ecosystem models in terms of pools and fluxes of carbon have been developed for the terrestrial (e.g. plants and animals) and limnic (e.g. algae and fish) systems using the Lake Frisksjoen drainage area. Furthermore, a first marine ecosystem model has been developed for the Basin Borholmsfjaerden. Three principal lithological domains have been defined in the subarea, an A domain that is dominated by the Aevroe granite, a domain B that is dominated by the fine-grained dioritoid, a C domain that is characterised by a mixture of of Aevroe granite and quartz monzodiorite. A fourth domain is made up a few scattered domains of diorite to gabbro. In total, 22 deformation zones with high confidence of occurrence have been interpreted in the local scale model area. The understanding of the interpreted deformation zones of the Simpevarp subarea is considered adequate to make a preliminary assessment of available storage volumes for a deep repository. High rock stresses do not appear to be a major concern for the Simpevarp subarea. The magnitude of the maximum principal stress at 500 m in the Simpevarp subarea is estimated at 10-22 MPa. The analysis of the thermal conductivity has developed considerably since Simpevarp 1.1. In terms of interpreted mean values for the identified lithological domains, the thermal conductivity varies within a relatively narrow interval (2.6-2.8 W/(m.K)). The hydraulic properties of the Hydraulic Rock Domains are described in terms of a network of discrete fractures (DFN) with a geometrical description taken from the geological DFN model. A fracture transmissivity distribution is superimposed, and calibrated against existing hydraulic borehole data. Numerical modelling shows that groundwater flow is controlled by topography and the geometry of the system of modelled deformation zones. The modelling also identifies the Simpevarp subarea as an area of groundwater discharge (upward directed flow) at repository depth. Suggested porosities for intact fresh rock (in terms mean values in vol-%) on lithological domain level vary from 0.17 (Fine-grained dioritoid) to 0.40 (Aevroegranite). Suggested formation factors for intact fresh (reflecting diffusion characteristics, mean values) on lithological domain level vary from about 1.0x10{sup -4} (Fine-grained dioritoid) to 2.9x10{sup -4} (Aevroe granite). Important modelling steps have been taken in Simpevarp 1.2 and the main uncertainties are identified, in some cases quantified, or explored as model alternatives. Notwithstanding, some uncertainties still remain unquantified at this stage, and alternative hypotheses are retained only as hypotheses. Additional data, collected in the Simpevarp subarea following the Simpevarp 1.2 data freeze, may allow additional quantification, and may help further reduce the observed uncertainties. For the geological model various possible alternative descriptions are inherent in uncertainties related to geometry, uncertainties in characteristics/properties and confidence of existence of modelled lithological domains and deformations zones. It is obvious that changes to the lithological model have a strong impact on most disciplines (e.g. rock mechanics, thermal and transport properties). The deformation zone model in particular influences the hydrogeological and rock mechanics models. Likewise, there is a strong interdependence between hydrogeology

  8. Influence of 1,2-PB matrix cross-linking on structure and properties of selectively etched 1,2-PB-b-PDMS block copolymers

    DEFF Research Database (Denmark)

    Guo, Fengxiao; Andreasen, Jens Wenzel; Vigild, Martin Etchells

    2007-01-01

    A series of samples with varying cross-linking degree were prepared from the same 1,2-polybutadiene-b-polydimethylsiloxane (1,2-PB-b-PDMS) diblock copolymer precursor. The stability of nanopores generated after PDMS cleaving depends on the cross-linking degree of 1,2-PB. The swelling ratio of the...

  9. Identification of high-risk Listeria monocytogenes serotypes in lineage I (serotype 1/2a, 1/2c, 3a and 3c) using multiplex PCR

    Science.gov (United States)

    Aims: Using molecular subtyping techniques, Listeria monocytogenes is divided into three major phylogenetic lineages, and a multiplex PCR method can differentiate five L. monocytogenes subgroups: 1/2a-3a, 1/2c-3c, 1/2b-3b-7, 4b-4d-4e, and 4a-4c. In the current study, we conducted genome comparison...

  10. Characterization of the uranium--2 weight percent molybdenum alloy. [Treatment to obtain 930 MPa yield strength (0. 2 percent)

    Energy Technology Data Exchange (ETDEWEB)

    Hemperly, V.C.

    1976-05-19

    The uranium-2 wt percent molybdenum alloy was prepared, processed, and age hardened to meet a minimum 930-MPa yield strength (0.2 percent) with a minimum of 10 percent elongation. These mechanical properties were obtained with a carbon level up to 300 ppM in the alloy. The tensile-test ductility is lowered by the humidity of the laboratory atmosphere. (auth)

  11. Preliminary site description Forsmark area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.)

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in methodology reports or strategy reports. A forum for technical coordination between the sites/projects controls that the methodology is applied as intended and is developed, if deemed necessary. The forum consists of specialists in each field as well as the project leaders of both modelling projects.

  12. The Texas Ten Percent Plan's Impact on College Enrollment

    Science.gov (United States)

    Daugherty, Lindsay; Martorell, Paco; McFarlin, Isaac, Jr.

    2014-01-01

    The Texas Ten Percent Plan (TTP) provides students in the top 10 percent of their high-school class with automatic admission to any public university in the state, including the two flagship schools, the University of Texas at Austin and Texas A&M. Texas created the policy in 1997 after a federal appellate court ruled that the state's previous…

  13. The Texas Ten Percent Plan's Impact on College Enrollment

    Science.gov (United States)

    Daugherty, Lindsay; Martorell, Paco; McFarlin, Isaac, Jr.

    2014-01-01

    The Texas Ten Percent Plan (TTP) provides students in the top 10 percent of their high-school class with automatic admission to any public university in the state, including the two flagship schools, the University of Texas at Austin and Texas A&M. Texas created the policy in 1997 after a federal appellate court ruled that the state's previous…

  14. Efimov physics with $1/2$ spin-isospin fermions

    CERN Document Server

    Kievsky, A

    2015-01-01

    The structure of few-fermion systems having $1/2$ spin-isospin symmetry is studied using potential models. The strength and range of the two-body potentials are fixed to describe low energy observables in the angular momentum $L=0$ state and spin $S=0,1$ channels of the two-body system. Successively the strength of the potentials are varied in order to explore energy regions in which the two-body scattering lengths are close to the unitary limit. This study is motivated by the fact that in the nuclear system the singlet and triplet scattering lengths are both large with respect to the range of the interaction. Accordingly we expect evidence of universal behavior in the three- and four-nucleon systems that can be observed from the study of correlations between observables. In particular we concentrate in the behavior of the first excited state of the three-nucleon system as the system moves away from the unitary limit. We also analyze the dependence on the range of the three-body force of some low-energy obser...

  15. Efimov Physics with {1/2} Spin-Isospin Fermions

    Science.gov (United States)

    Kievsky, A.; Gattobigio, M.

    2016-03-01

    The structure of few-fermion systems having {1/2} spin-isospin symmetry is studied using potential models. The strength and range of the two-body potentials are fixed to describe low energy observables in the angular momentum {L=0} state and spin {S=0,1} channels of the two-body system. Successively the strength of the potentials are varied in order to explore energy regions in which the two-body scattering lengths are close to the unitary limit. This study is motivated by the fact that in the nuclear system the singlet and triplet scattering lengths are both large with respect to the range of the interaction. Accordingly we expect evidence of universal behavior in the three- and four-nucleon systems that can be observed from the study of correlations between observables. In particular we concentrate in the behavior of the first excited state of the three-nucleon system as the system moves away from the unitary limit. We also analyze the dependence on the range of the three-body force of some low-energy observables in the three- and four-nucleon systems.

  16. The Beetle Reference Manual chip version 1.2

    CERN Document Server

    Baumeister, D; Schmelling, M

    2006-01-01

    This paper details the electrical specifications, operating conditions and port definitions of the readout chip Beetle 1.2. The chip is developed for the LHCb experiment and fulfils the requirements of the silicon vertex detector (VELO, VETO), the silicon tracker and the RICH detector in case of multi-anode photomultiplier readout. It integrates 128 channels with low-noise charge-sensitive preamplifiers and shapers. The pulse shape can be chosen such that it complies with LHCb specifications: a peaking time of 25 ns with a remainder of the peak voltage after 25 ns of less than 30%. A comparator per channel with configurable polarity provides a binary signal. Four adjacent comparator channels are being ORed and brought off chip via LVDS ports. Either the shaper or comparator output is sampled with the LHC-bunch-crossing frequency of 40 MHz into an analog pipeline. This ring buffer has a programmable latency of max. 160 sampling intervals and an integrated derandomising buffer of 16 stages. For analog readout d...

  17. Bipartite entanglement in spin-1/2Heisenberg model

    Institute of Scientific and Technical Information of China (English)

    HU Ming-Liang; TIAN Dong-Ping

    2008-01-01

    The bipartite entanglement of the two-and three-spin Heisenberg model was investigated by using the concept of negativity.It is found that for the ground-state entanglement of the two-spin model,the negativity always decreases as B increases if A Δ<y-1,and it may keep a steady value of 0.5in the region of B<J[(Δ+1)2-y2]1/2if Δ>y-1,while for that of the three-spin model,the negativity exhibits square wave structures if y=0 or Δ=0.For thermal states,there are two areas showing entanglement,namely,the main region and the sub-region.The main region exists only when Δ>Δc(Δc1=and(y2-1)/2for the 2-and 3-spin model respectively)and extends in terms of B and T as Δ increases,while the sub-region survives only when y≠0 and shrinks in terms of B and T as Δ increases.

  18. Sparse SAR imaging based on L1/2 regularization

    Institute of Scientific and Technical Information of China (English)

    ZENG JinShan; FANG Jian; XU ZongBen

    2012-01-01

    In this paper,a novel method for synthetic aperture radar (SAR) imaging is proposed.The approach is based on L1/2 regularization to reconstruct the scattering field,which optimizes a quadratic error term of the SAR observation process subject to the interested scene sparsity. Compared to the conventional SAR imaging technique,the new method implements SAR imaging effectively at much lower sampling rate than the Nyquist rate,and produces high-quality images with reduced sidelobes and increased resolution. Also,over the prevalent greedy pursuit and L1 regularization based SAR imaging methods,there are remarkable performance improvements of the new method.On one hand,the new method significantly reduces the number of measurements needed for reconstruction,as supported by a phase transition diagram study.On the other hand,the new method is more robust to the observation noise.These fundamental properties of the new method are supported and demonstrated both by simulations and real SAR data experiments.

  19. RAG1/2 knockout pigs with severe combined immunodeficiency.

    Science.gov (United States)

    Huang, Jiao; Guo, Xiaogang; Fan, Nana; Song, Jun; Zhao, Bentian; Ouyang, Zhen; Liu, Zhaoming; Zhao, Yu; Yan, Quanmei; Yi, Xiaoling; Schambach, Axel; Frampton, Jon; Esteban, Miguel A; Yang, Dongshan; Yang, Huaqiang; Lai, Liangxue

    2014-08-01

    Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research. Considering the advantages in immune system resemblance, suitable size, and longevity for clinical practical and monitoring purpose, SCID pigs bearing dysfunctional RAG could serve as important experimental tools for regenerative medicine, allograft and xenograft transplantation, and reconstitution experiments related to the immune system. In this study, we report the generation and phenotypic characterization of RAG1 and RAG2 knockout pigs using transcription activator-like effector nucleases. Porcine fetal fibroblasts were genetically engineered using transcription activator-like effector nucleases and then used to provide donor nuclei for somatic cell nuclear transfer. We obtained 27 live cloned piglets; among these piglets, 9 were targeted with biallelic mutations in RAG1, 3 were targeted with biallelic mutations in RAG2, and 10 were targeted with a monoallelic mutation in RAG2. Piglets with biallelic mutations in either RAG1 or RAG2 exhibited hypoplasia of immune organs, failed to perform V(D)J rearrangement, and lost mature B and T cells. These immunodeficient RAG1/2 knockout pigs are promising tools for biomedical and translational research.

  20. Vapor intrusion risk of lead scavengers 1,2-dibromoethane (EDB) and 1,2-dichloroethane (DCA).

    Science.gov (United States)

    Ma, Jie; Li, Haiyan; Spiese, Richard; Wilson, John; Yan, Guangxu; Guo, Shaohui

    2016-06-01

    Vapor intrusion of synthetic fuel additives represented a critical yet still neglected problem at sites impacted by petroleum fuel releases. This study used an advanced numerical model to simulate the vapor intrusion risk of lead scavengers 1,2-dibromoethane (ethylene dibromide, EDB) and 1,2-dichloroethane (DCA) under different site conditions. We found that simulated EDB and DCA indoor air concentrations can exceed USEPA screening level (4.7 × 10(-3) μg/m(3) for EDB and 1.1 × 10(-1) μg/m(3) for DCA) if the source concentration is high enough (is still within the concentration range found at leaking UST site). To evaluate the chance that vapor intrusion of EDB might exceed the USEPA screening levels for indoor air, the simulation results were compared to the distribution of EDB at leaking UST sites in the US. If there is no degradation of EDB or only abiotic degradation of EDB, from 15% to 37% of leaking UST sites might exceed the USEPA screening level. This study supports the statements made by USEPA in the Petroleum Vapor Intrusion (PVI) Guidance that the screening criteria for petroleum hydrocarbon may not provide sufficient protectiveness for fuel releases containing EDB and DCA. Based on a thorough literature review, we also compiled previous published data on the EDB and DCA groundwater source concentrations and their degradation rates. These data are valuable in evaluating EDB and DCA vapor intrusion risk. In addition, a set of refined attenuation factors based on site-specific information (e.g., soil types, source depths, and degradation rates) were provided for establishing site-specific screening criteria for EDB and DCA. Overall, this study points out that lead scavengers EDB and DCA may cause vapor intrusion problems. As more field data of EDB and DCA become available, we recommend that USEPA consider including these data in the existing PVI database and possibly revising the PVI Guidance as necessary.

  1. Thermal-shock Resistance of a Ceramic Comprising 60 Percent Boron Carbide and 40 Percent Titanium Diboride

    Science.gov (United States)

    Yeomans, C M; Hoffman, C A

    1953-01-01

    Thermal-shock resistance of a ceramic comprising 60 percent boron carbide and 40 percent titanium diboride was investigated. The material has thermal shock resistance comparable to that of NBS body 4811C and that of zirconia, but is inferior to beryllia, alumina, and titanium-carbide ceramals. It is not considered suitable for turbine blades.

  2. Using R in Taverna: RShell v1.2

    Directory of Open Access Journals (Sweden)

    Breit Timo M

    2009-07-01

    Full Text Available Abstract Background R is the statistical language commonly used by many life scientists in (omics data analysis. At the same time, these complex analyses benefit from a workflow approach, such as used by the open source workflow management system Taverna. However, Taverna had limited support for R, because it supported just a few data types and only a single output. Also, there was no support for graphical output and persistent sessions. Altogether this made using R in Taverna impractical. Findings We have developed an R plugin for Taverna: RShell, which provides R functionality within workflows designed in Taverna. In order to fully support the R language, our RShell plugin directly uses the R interpreter. The RShell plugin consists of a Taverna processor for R scripts and an RShell Session Manager that communicates with the R server. We made the RShell processor highly configurable allowing the user to define multiple inputs and outputs. Also, various data types are supported, such as strings, numeric data and images. To limit data transport between multiple RShell processors, the RShell plugin also supports persistent sessions. Here, we will describe the architecture of RShell and the new features that are introduced in version 1.2, i.e.: i Support for R up to and including R version 2.9; ii Support for persistent sessions to limit data transfer; iii Support for vector graphics output through PDF; ivSyntax highlighting of the R code; v Improved usability through fewer port types. Our new RShell processor is backwards compatible with workflows that use older versions of the RShell processor. We demonstrate the value of the RShell processor by a use-case workflow that maps oligonucleotide probes designed with DNA sequence information from Vega onto the Ensembl genome assembly. Conclusion Our RShell plugin enables Taverna users to employ R scripts within their workflows in a highly configurable way.

  3. [1,2-Bis(diisopropylphosphanylethane-κ2P,P′]dichloridonickel(II–9H-carbazole (1/2

    Directory of Open Access Journals (Sweden)

    Farah Cañavera-Buelvas

    2011-04-01

    Full Text Available In the title compound, [NiCl2(C14H32P2]·2C12H9N, the neutral [Ni(dppeCl2] complex [dppe is 1,2-bis(diisopropylphosphanylethane] consists of a tetracoordinated Ni2+ cation and has a crystallographic twofold axis passing through the metal atom and the mid-point of the CH2—CH2 bond of the dppe ligand. The metal atom shows slight tetrahedral distortion from an ideal square-planar coordination geometry, as reflected in the dihedral angle between NiCl2 and NiP2 planes of 15.32 (2°. The 9H-carbazole ring system is essentially planar (r.m.s. deviation = 0.022 Å. In the crystal packing, there are two symmetry-related 9H-carbazole molecules between two adjacent NiII complexes, with an angle between the carbazole mean planes of ca 77°.

  4. Hospital-based surveillance for HTLV-1/2 infections in Spain.

    Science.gov (United States)

    Toro, Carlos; Aguilera, Antonio; Caballero, Estrella; Tuset, Concepción; Alvarez, Patricia; García-Campello, Marta; Rodríguez-Iglesias, Manuel; de Lejarazu, Raúl Ortiz; Eiros, José; Rodriguez, Carmen; del Romero, Jorge; Benito, Rafael; Calderón, Enrique; Santana, Otilia; Amor, Aránzazu; Gómez-Hernando, César; García, Juan; Soriano, Vincent

    2007-09-01

    In Western countries, HTLV-1 infection is recognized mainly among foreigners coming from endemic areas. In contrast, HTLV-2 is found predominantly in native intravenous drug users (IDUs). Spain has experienced a large wave of immigration, which could have influenced the current prevalence and distribution of HTLV-1 and HTLV-2 infection. A 1-day cross-sectional survey was carried out in May 2005 in 13 hospitals distributed across Spain. A total of 2873 outpatient subjects were screened for HTLV-1/2 antibodies. Although the majority of the study population consisted of native Spaniards, 206 (7.2%) were immigrants. Two cases of HTLV-1 and one of HTLV-2 infection were found (overall prevalence, 0.1%). The two individuals with HTLV-1 were immigrants from endemic areas and the single case of HTLV-2 infection was a former Spaniard IDU coinfected with HIV-1. In summary, the current prevalence of HTLV-1/2 infection in Spain is low, with no evidence of spread beyond the classical risk groups. However, a rapidly growing population of immigrants from HTLV-1-endemic areas in Spain could modify this pattern and periodic surveillance studies including both natives and immigrants are warranted.

  5. Ordering of the $0d_{5/2}$ and $1s_{1/2}$ proton levels in light nuclei

    CERN Document Server

    Hoffman, C R; Schiffer, J P

    2016-01-01

    A survey of the available single-proton data in $A\\leq17$ nuclei, along with calculations using a Woods-Saxon potential, show that the ordering of the $0d_{5/2}$ and $1s_{1/2}$ proton orbitals are determined primarily by the proximity of the $s$-state proton energy to the Coulomb barrier. This is analogous to the dependence of the corresponding neutron orbitals in proximity to the neutron threshold, that was previously discussed.

  6. Analysis of Percent Elongation for Ductile Metal in Uniaxial Tension

    Institute of Scientific and Technical Information of China (English)

    WANG Xue-bin; YANG Mei; JIANG Jian

    2005-01-01

    Percent elongation of ductile metal in uniaxial tension due to non-homogeneity was analyzed based on gradient-dependent plasticity. Three assumptions are used to get the analytical solution of percent elongation: one is static equilibrium condition in axial direction; another is that plastic volumetric strain is zero in necking zone;the other is that the diameter in unloading zone remains constant after strain localization is initiated. The strain gradient term was introduced into the yield function of classical plastic mechanics to obtain the analytical solution of distributed plastic strain. Integrating the plastic strain and considering the influence of necking on plastic elongation, a one-dimensional analytical solution of percent elongation was proposed. The analytical solution shows that the percent elongation is inversely proportional to the gauge length, and the solution is formally similar to earlier empirical formula proposed by Barba. Comparisons of existing experimental results and present analytical solutions for relation between load and total elongation and for relation between percent elongation and gauge lengthwere carried out and the new mechanical model for percent elongation was verified. Moreover, higher ductility,toughness and heterogeneity can cause much larger percentage elongation, which coincides with usual viewpoints.

  7. High Field Magnetization Studies of Low Dimensional Heisenberg S = 1/2 Antiferromagnets

    Science.gov (United States)

    Landee, C. P.; Turnbull, M. M.

    1998-03-01

    The magnetization curves of a number of low dimensional S=1/2 Heisenberg antiferromagnets have been determined in fields up to 30 tesla at low temperatures at the National High Magnetic Fields Laboratory. Materials studied include a family of 1D materials, based upon Cu(pyrazine)(NO_3)_2, 2D magnets consisting of pyrazine-bridged copper layers, and several spin ladders with singlet ground states. All of the magnetization data show upward curvature and are well described by T = 0 calculations based upon finite cluster models(Bonner and Fisher, Phys. Rev. A135, 640 (1964); Yang and Mutter, NANL cond-mat/9610092.). Chemical substitution on the pyrazine rings permits the variation of exchange constants by more than 25 percent for the family of well isolated chains. The spin ladder systems consist of ferromagnetic dimers weakly connected by antiferromagnetic intradimer interactions. Field induced transitions are seen at fields of less than one tesla for each of the three compounds.

  8. Large data analysis: automatic visual personal identification in a demography of 1.2 billion persons

    Science.gov (United States)

    Daugman, John

    2014-05-01

    The largest biometric deployment in history is now underway in India, where the Government is enrolling the iris patterns (among other data) of all 1.2 billion citizens. The purpose of the Unique Identification Authority of India (UIDAI) is to ensure fair access to welfare benefits and entitlements, to reduce fraud, and enhance social inclusion. Only a minority of Indian citizens have bank accounts; only 4 percent possess passports; and less than half of all aid money reaches its intended recipients. A person who lacks any means of establishing their identity is excluded from entitlements and does not officially exist; thus the slogan of UIDAI is: To give the poor an identity." This ambitious program enrolls a million people every day, across 36,000 stations run by 83 agencies, with a 3-year completion target for the entire national population. The halfway point was recently passed with more than 600 million persons now enrolled. In order to detect and prevent duplicate identities, every iris pattern that is enrolled is first compared against all others enrolled so far; thus the daily workflow now requires 600 trillion (or 600 million-million) iris cross-comparisons. Avoiding identity collisions (False Matches) requires high biometric entropy, and achieving the tremendous match speed requires phase bit coding. Both of these requirements are being delivered operationally by wavelet methods developed by the author for encoding and comparing iris patterns, which will be the focus of this Large Data Award" presentation.

  9. Studies of Electrochemical Catalytic Reduction Reactions of Tetraphenylporphinatocobalt/1,2-Dibromoethane and 1,2-Dichloroethane Systems in Nonaqueous Media

    Institute of Scientific and Technical Information of China (English)

    林祥钦; 刘殿骏; 汪尔康

    1994-01-01

    Electrochemical catalytic reactions of tetraphenylporphmatocobalt were studied in DMF and EtCl2 solutions in the presence of 1,2 dibroraoethane and 1,2-dichloroethane utilizing cyclic voltamme-try, thin-layer electrochemistry, in situ UV-visible spectroelectrochemistry and computer digital simulation methods. Homogeneous rate constants for reactions of electrogenerated Co(Ⅰ)TPP species with 1,2-dibro-moethane and 1,2-dichloroethane were determined as 1. 2×103 and 5 mol-1 · dm3 × s-1, respectively. Neither alkylation nor degradation of CoTPP was observed.

  10. Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%-Benzoyl Peroxide 3% Combination Gel.

    Science.gov (United States)

    Jones, Terry M; Jasper, Stacy; Alió Sáenz, Alessandra B

    2013-01-01

    A new topical fixed-dose combination product containing clindamycin (1%, formulated as 1.2% clindamycin phosphate, CLNP 1.2%) with low strength (3%) benzoyl peroxide (BPO) in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 3%-MPF) has been developed for the treatment of acne. The objective of this study was to determine the relative bioavailability of clindamycin and clindamycin sulfoxide from CLNP 1.2%-BPO 3%-MPF compared with clindamycin phosphate 1.2%-BPO 5% in a methylparaben-preserved gel vehicle (CLNP 1.2%-BPO 5%-MP) and clindamycin phosphate 1.2%-BPO 5% in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 5%-MPF), and to determine whether exposure is affected by BPO concentration (3% vs. 5%) when applied topically. Seventy-two subjects with moderate-severe acne were randomized to receive CLNP 1.2%-BPO 3%-MPF, CLNP 1.2%-BPO 5%-MP, or CLNP 1.2%-BPO 5%-MPF in a 5-day, open-label, and parallel-group study. Cmax and AUC values for clindamycin were highest for CLNP 1.2%-BPO 5%-MP, followed by CLNP 1.2%-BPO 3%-MPF and CLNP 1.2%-BPO 5%-MPF, but differences were not statistically significant. Systemic exposure to clindamycin and clindamycin sulfoxide was low and comparable between the formulations. Results indicate that differences in BPO concentration do not influence clindamycin bioavailability.

  11. Water Security Toolkit User Manual Version 1.2.

    Energy Technology Data Exchange (ETDEWEB)

    Klise, Katherine A.; Siirola, John Daniel; Hart, David; Hart, William Eugene; Phillips, Cynthia Ann; Haxton, Terranna; Murray, Regan; Janke, Robert; Taxon, Thomas; Laird, Carl; Seth, Arpan; Hackebeil, Gabriel; McGee, Shawn; Mann, Angelica

    2014-08-01

    The Water Security Toolkit (WST) is a suite of open source software tools that can be used by water utilities to create response strategies to reduce the impact of contamination in a water distribution network . WST includes hydraulic and water quality modeling software , optimizati on methodologies , and visualization tools to identify: (1) sensor locations to detect contamination, (2) locations in the network in which the contamination was introduced, (3) hydrants to remove contaminated water from the distribution system, (4) locations in the network to inject decontamination agents to inactivate, remove, or destroy contaminants, (5) locations in the network to take grab sample s to help identify the source of contamination and (6) valves to close in order to isolate contaminate d areas of the network. This user manual describes the different components of WST , along w ith examples and case studies. License Notice The Water Security Toolkit (WST) v.1.2 Copyright c 2012 Sandia Corporation. Under the terms of Contract DE-AC04-94AL85000, there is a non-exclusive license for use of this work by or on behalf of the U.S. government. This software is distributed under the Revised BSD License (see below). In addition, WST leverages a variety of third-party software packages, which have separate licensing policies: Acro Revised BSD License argparse Python Software Foundation License Boost Boost Software License Coopr Revised BSD License Coverage BSD License Distribute Python Software Foundation License / Zope Public License EPANET Public Domain EPANET-ERD Revised BSD License EPANET-MSX GNU Lesser General Public License (LGPL) v.3 gcovr Revised BSD License GRASP AT&T Commercial License for noncommercial use; includes randomsample and sideconstraints executable files LZMA SDK Public Domain nose GNU Lesser General Public License (LGPL) v.2.1 ordereddict MIT License pip MIT License PLY BSD License PyEPANET Revised BSD License Pyro MIT License PyUtilib Revised BSD License PyYAML MIT License runpy2 Python Software Foundation License setuptools Python Software Foundation License / Zope Public License six MIT License TinyXML zlib License unittest2 BSD License Utilib Revised BSD License virtualenv MIT License Vol Common Public License vpykit Revised BSD License Additionally, some precompiled WST binary distributions might bundle other third-party executables files: Coliny Revised BSD License (part of Acro project) Dakota GNU Lesser General Public License (LGPL) v.2.1 PICO Revised BSD License (part of Acro project) i Revised BSD License Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: * Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. * Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. * Neither the name of Sandia National Laboratories nor Sandia Corporation nor the names of its con- tributors may be used to endorse or promote products derived from this software without specific prior written permission. THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IM- PLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL SANDIA CORPORATION BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUD- ING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. ii Acknowledgements This work was supported by the U.S. Environmental Protectio

  12. BRCA1/2 mutations appear embryo-lethal unless rescued by low (CGG n<26 FMR1 sub-genotypes: explanation for the "BRCA paradox"?

    Directory of Open Access Journals (Sweden)

    Andrea Weghofer

    Full Text Available BRCA1/2 mutations and recently described constitutional FMR1 genotypes have, independently, been associated with prematurely diminished ovarian reserve. Whether they interrelate in distribution, and whether observed effects of BRCA1/2 and FMR1 on ovaries are independent of each other, is unknown. In a prospective comparative cohort study, we, therefore, investigated the distribution of constitutional FMR1 genotypes, normal (norm, heterozygous (het and homozygous (hom, and of their respective sub-genotypes (high/low, in 99 BRCA1/2 mutation-positive women and 410 female controls to determine whether distribution patterns differed between study and control patients. In contrast to controls, BRCA1/2 carriers demonstrated almost complete absence of all constitutional FMR1 genotypes except for sub-genotypes with low (CGG (n<26 alleles. Cross tabulation between BRCA1/2-positive patients and controls confirmed significant group membership, related to FMR1 distribution (P<0.0001. These results offer as most likely explanation the conclusion that BRCA1/2 mutations are embryo-lethal, unless rescued by low (CGG (n<26 FMR1 sub-genotypes, present in approximately one quarter of all women. Women with low FMR1 sub-genotypes, therefore, should reflect increased BRCA1/2-associated cancer risks, while the remaining approximately 75 percent should face almost no such risks. If confirmed, this observation offers opportunities for more efficient and less costly BRCA1/2 cancer screening. The study also suggests that previously reported risk towards prematurely diminished ovarian reserve in association with BRCA mutations is FMR1-mediated, and offers a possible explanation for the so-called "BRCA paradox" by raising the possibility that the widely perceived BRCA1/2-associated tumor risk is actually FMR1-mediated.

  13. Percent body fat, fractures and risk of osteoporosis in women.

    Science.gov (United States)

    Wyshak, G

    2010-06-01

    Globally, in an aging population, osteoporosis and fractures are emerging as major public health problems; accessible and affordable recognition, prevention and treatment strategies are needed. Percent body fat is known to be associated with bone mineral density and fractures. This paper uses an innovative, virtually cost-free method to estimate percent body fat from age, height and weight, and assesses its validity by examining the association between percent body fat and fractures among women 39 and older. An epidemiologic study. 3940 college alumnae, median age 53.6, participated by responding to a mailed questionnaire covering medical history, behavioral factors, birth date, weight and height. T-tests, chi-square and multivariable logistic regression. Percent body fat estimated from age, weight, height and gender. Associations of fractures with percent body fat are expressed as odds ratios: for osteoporotic (wrist, hip and/or x-ray confirmed vertebral), the adjusted OR = 2.41, 95% CI (1.65, 3.54), P age, height and weight may be a valid, cost-saving, and cost-effective alternative tool for screening and assessing risk of osteoporosis in settings where Dual x-ray absorptiometry (DXA) or other radiological techniques are too costly or unavailable.

  14. An Expeditious Synthesis of [1,2]Isoxazolidin-5-ones and [1,2]Oxazin-6-ones from Functional Allyl Bromide Derivatives

    Directory of Open Access Journals (Sweden)

    Imen Beltaïef

    2010-06-01

    Full Text Available Reaction of allyl bromide (Z-1 and (Z-2 with N-substituted hydroxylamine hydrochlorides in presence of tert-butoxide in tert-butanol at reflux provides a short and effective route to [1,2]isoxazolidin-5-ones 3 and [1,2]oxazin-6-ones 4.

  15. An Efficient Algorithm for Simulating the Real-Time Quantum Dynamics of a Single Spin-1/2 Coupled to Specific Spin-1/2 Baths

    NARCIS (Netherlands)

    Novotny, M.A.; Guerra, M.; Raedt, H. De; Michielsen, K.; Jin, F.

    2012-01-01

    An efficient algorithm for the computation of the real-time dependence of a single quantum spin-1/2 coupled to a specific set of quantum spin-1/2 baths is presented. The specific spin baths have couplings only with the spin operators Sx between bath spins and the central spin. We calculate spin expe

  16. Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo

    NARCIS (Netherlands)

    N.C. Weber; J. Stursberg; N.M. Wirthle; O. Toma; W. Schlack; B. Preckel

    2006-01-01

    Background. Xenon (Xe) induces preconditioning (PC) of the rat heart in vivo via activation of p38 mitogen-activated protein kinase (MAPK). The role of ERK 1/2 and JNK 1/2 and 3 in Xe-PC has yet not been determined. Methods. For infarct size measurements, anaesthetized rats were subjected to 25 min

  17. Cross-talk between MEK1/2-ERK1/2 signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis rats

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ling-ling; WEI Wei; WANG Qing-tong; CHEN Jing-yu; CHEN Yin

    2008-01-01

    Background Signaling pathways that regulate the production of cytokines and destructive enzymes have been implicated in rheumatoid arthritis (RA) pathogenesis.There are co-relations between signaling pathways.The aim of this study was to investigate interactions and cross-talks between MEK1/2-extracellular signal-related kinase (ERK1/2)signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis (CIA) rats by the stimulation of interleukin-1 (IL-1),U0126,isoprenaline hydrochloride and aminophyline respectively.Methods Twenty Sprague-Dawley (SD) rats were induced by chicken type Ⅱ collagen.Synoviocytes of CIA rats were isolated and cultured.The expressions of Gi,phosphorylated MEK1/2 (p-MEK1/2) and phosphorylated ERK1/2 (p-ERK1/2) were detected by Western blotting.cAMP level and protein kinase A (PKA) activity were measured by radioimmunoassay and kinase-glo(R) luminescent kinase assay respectively.Results There was remarkable inflammation in CIA rats accompanied by swelling paws,hyperplastic synovium,pannus and cartilage erosion,cAMP level and PKA activity of synoviocytes decreased.Gi,p-ERK1/2 and p-MEK1/2 increased,rIL-1α improved the expression of Gi,p-ERK1/2 and p-MEK1/2,cAMP and PKA increased with stimulation of rIL-1α.U0126 inhibited Gi,cAMP and PKA of synoviocytes stimulated by rIL-1α.Isoprenaline hydrochloride enhanced Gi,cAMP and PKA,but had no effects on p-MEK1/2 and p-ERK1/2.Aminophyline increased cAMP and PKA,but inhibited p-MEK1/2 and p-ERK1/2.Conclusions Mitogen-activated protein kinases (MAPKs) and G protein-couple signaling are associated with synovitis.There are cross talks between MAPKs and G protein-couple signaling.The two signaling pathways represent potential therapeutic targets for RA.

  18. Cluster candidates around low power radio-galaxies at z~1-2 in COSMOS

    CERN Document Server

    Castignani, Gianluca; Celotti, Annalisa; Norman, Colin; De Zotti, Gianfranco

    2014-01-01

    We search for high redshift ($z\\sim$1-2) galaxy clusters using low luminosity radio galaxies (FR~I) as beacons and our newly developed Poisson Probability Method (PPM) based on photometric redshift information and galaxy number counts. We use a sample of 32 FR~Is within the Cosmic Evolution Survey (COSMOS) field from Chiaberge et al. (2009) catalog. We derive a reliable subsample of 21 {\\it bona fide} Low Luminosity Radio Galaxies (LLRGs) and a subsample of 11 High Luminosity Radio Galaxies (HLRGs), on the basis of photometric redshift information and NRAO VLA Sky Survey (NVSS) radio fluxes. The LLRGs are selected to have 1.4~GHz rest frame luminosities lower than the fiducial FR~I/FR~II divide. This also allows us to estimate the comoving space density of sources with $L_{1.4}\\simeq 10^{32.3}\\,\\hbox{erg}\\,\\hbox{s}^{-1}\\,\\hbox{Hz}^{-1}$ at $z\\simeq 1.1$, which strengthens the case for a strong cosmological evolution of these sources. In the fields of the LLRGs and HLRGs we find evidence that 14 and 8 of them ...

  19. Absence of HTLV-1/2 infection and dermatological diseases in Manaus, State of Amazonas, Brazil.

    Science.gov (United States)

    Passos, Leny Nascimento da Motta; Moraes, Márcia Poinho Encarnação de; Tamegão-Lopes, Bruna; Lemos, José Alexandre Rodrigues de; Machado, Paulo Roberto de Lima; Mira, Marcelo Távora; Talhari, Sinésio

    2014-07-01

    The prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection is heterogeneous across different populations. We tested the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients. A total of 1,091 patients from a tropical dermatology clinic were tested for HTLV-1/2. In parallel, 6865 first-time blood donors from the same geographic area were screened for HTLV-1/2; HTLV-1/2 positive blood donors underwent dermatological examinations. The prevalence of HTLV-1/2 in first-time blood donors was 0.14%. No co-occurrence of HTLV-1/2 infection and dermatological conditions was observed. Our results challenge the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients.

  20. Comparing proton conductivity of polymer electrolytes by percent conducting volume

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu Seung [Los Alamos National Laboratory; Pivovar, Bryan [NREL

    2009-01-01

    Proton conductivity of sulfonated polymers plays a key role in polymer electrolyte membrane fuel cells. Mass based water uptake and ion exchange capacity of sulfonated polymers have been failed to correlating their proton conductivity. In this paper, we report a length scale parameter, percent conductivity volume, which is rather simply obtained from the chemical structure of polymer to compare proton conductivity of wholly aromatic sulfonated polymer perflurosulfonic acid. Morphology effect on proton conductivity at lower RH conditions is discussed using the percent conductivity volume parameter.

  1. Anaerobic Biodegradation of Ethylene Dibromide and 1,2-Dichloroethane in the Presence of Fuel Hydrocarbons

    Science.gov (United States)

    Field evidence from underground storage tank sites where leaded gasoline leaked indicates the lead scavengers 1,2- dibromoethane (ethylene dibromide, or EDB) and 1,2- dichloroethane (1,2-DCA) may be present in groundwater at levels that pose unacceptable risk. These compounds are...

  2. 17 CFR 1.2 - Liability of principal for act of agent.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Liability of principal for act of agent. 1.2 Section 1.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.2 Liability of principal for act of...

  3. Evaluating Equating Results: Percent Relative Error for Chained Kernel Equating

    Science.gov (United States)

    Jiang, Yanlin; von Davier, Alina A.; Chen, Haiwen

    2012-01-01

    This article presents a method for evaluating equating results. Within the kernel equating framework, the percent relative error (PRE) for chained equipercentile equating was computed under the nonequivalent groups with anchor test (NEAT) design. The method was applied to two data sets to obtain the PRE, which can be used to measure equating…

  4. 35 GHz integrated circuit rectifying antenna with 33 percent efficiency

    Science.gov (United States)

    Yoo, T.-W.; Chang, K.

    1991-01-01

    A 35 GHz integrated circuit rectifying antenna (rectenna) has been developed using a microstrip dipole antenna and beam-lead mixer diode. Greater than 33 percent conversion efficiency has been achieved. The circuit should have applications in microwave/millimeter-wave power transmission and detection.

  5. 1,2-环己二醇的焓和热容数据研究%Enthalpy and Heat Capacity Data for 1,2-Cyclohexanediol

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 章亚东; 蒋登高

    2003-01-01

    The thermodynamic properties of different geometric structures of 1,2-cyclohexanediol which were rarely reported in literature, such as combustion enthalpy, formation enthalpy, melting enthalpy and heat capacities, were determined by NETZSCH DSC 204 Scanning Calorimeter. The relationship between the melting point and the composition for the mixture system of cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol was investigated and corresponding phase diagram was obtained. The melting enthMpies of both cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol are 20.265 kJ·mol-1 and 16.368 kJ·mol-1 respectively. The standard combustion enthalpies of cis- and trans-1,2-cyclohexaneddiol were determined by calorimeter. They are respectively -3507.043 kJ·mol-1 and -3497.8 k J·mol-1 at 298.15 K.The standard formation enthalpies are respectively 568.997kJ·mol-1and 578.240kJ·mol-1 for cis- and trans-1,2-cyclohexaneddiol.

  6. Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease

    Directory of Open Access Journals (Sweden)

    Ingrid Stroo

    2012-10-01

    It is indispensable to thoroughly characterize each animal model in order to distinguish between primary and secondary effects of genetic changes. The present study analyzed Nod1 and Nod2 double deficient (Nod1/2 DKO mice under physiological and inflammatory conditions. Nod1 and Nod2 are members of the Nucleotide-binding domain and Leucine-rich repeat containing Receptor (NLR family. Several inflammatory disorders, such as Crohn's disease and asthma, are linked to genetic changes in either Nod1 or Nod2. These associations suggest that Nod1 and Nod2 play important roles in regulating the immune system. Three-month-old wildtype (Wt and Nod1/2 DKO mice were sacrificed, body and organ weight were determined, and blood was drawn. Except for lower liver weight in Nod1/2 DKO mice, no differences were found in body/organ weight between both strains. Leukocyte count and composition was comparable. No significant changes in analyzed plasma biochemical markers were found. Additionally, intestinal and vascular permeability was determined. Nod1/2 DKO mice show increased susceptibility for intestinal permeability while vascular permeability was not affected. Next we induced septic shock and organ damage by administering LPS+PGN intraperitoneally to Wt and Nod1/2 DKO mice and sacrificed animals after 2 and 24 hours. The systemic inflammatory and metabolic response was comparable between both strains. However, renal response was different as indicated by partly preserved kidney function and tubular epithelial cell damage in Nod1/2 DKO at 24 hours. Remarkably, renal inflammatory mediators Tnfα, KC and Il-10 were significantly increased in Nod1/2 DKO compared with Wt mice at 2 hours. Systematic analysis of Nod1/2 DKO mice revealed a possible role of Nod1/2 in the development of renal disease during systemic inflammation.

  7. Pseudorabies Virus Triggers Glycoprotein gE-Mediated ERK1/2 Activation and ERK1/2-Dependent Migratory Behavior in T Cells

    Science.gov (United States)

    Setas Pontes, Maria; Devriendt, Bert

    2014-01-01

    ABSTRACT The interaction between viruses and immune cells of the host may lead to modulation of intracellular signaling pathways and to subsequent changes in cellular behavior that are of benefit for either virus or host. ERK1/2 (extracellular signal regulated kinase 1/2) signaling represents one of the key cellular signaling axes. Here, using wild-type and gE null virus, recombinant gE, and gE-transfected cells, we show that the gE glycoprotein of the porcine Varicellovirus pseudorabies virus (PRV) triggers ERK1/2 phosphorylation in Jurkat T cells and primary porcine T lymphocytes. PRV-induced ERK1/2 signaling resulted in homotypic T cell aggregation and increased motility of T lymphocytes. Our study reveals a new function of the gE glycoprotein of PRV and suggests that PRV, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior. IMPORTANCE Herpesviruses are known to be highly successful in evading the immune system of their hosts, subverting signaling pathways of the host to their own advantage. The ERK1/2 signaling pathway, being involved in many cellular processes, represents a particularly attractive target for viral manipulation. Glycoprotein E (gE) is an important virulence factor of alphaherpesviruses, involved in viral spread. In this study, we show that gE has the previously uncharacterized ability to trigger ERK1/2 phosphorylation in T lymphocytes. We also show that virus-induced ERK1/2 signaling leads to increased migratory behavior of T cells and that migratory T cells can spread the infection to susceptible cells. In conclusion, our results point to a novel function for gE and suggest that virus-induced ERK1/2 activation may trigger PRV-carrying T lymphocytes to migrate and infect other cells susceptible to PRV replication. PMID:25473050

  8. Serum Predictors of Percent Lean Mass in Young Adults.

    Science.gov (United States)

    Lustgarten, Michael S; Price, Lori L; Phillips, Edward M; Kirn, Dylan R; Mills, John; Fielding, Roger A

    2016-08-01

    Lustgarten, MS, Price, LL, Phillips, EM, Kirn, DR, Mills, J, and Fielding, RA. Serum predictors of percent lean mass in young adults. J Strength Cond Res 30(8): 2194-2201, 2016-Elevated lean (skeletal muscle) mass is associated with increased muscle strength and anaerobic exercise performance, whereas low levels of lean mass are associated with insulin resistance and sarcopenia. Therefore, studies aimed at obtaining an improved understanding of mechanisms related to the quantity of lean mass are of interest. Percent lean mass (total lean mass/body weight × 100) in 77 young subjects (18-35 years) was measured with dual-energy x-ray absorptiometry. Twenty analytes and 296 metabolites were evaluated with the use of the standard chemistry screen and mass spectrometry-based metabolomic profiling, respectively. Sex-adjusted multivariable linear regression was used to determine serum analytes and metabolites significantly (p ≤ 0.05 and q ≤ 0.30) associated with the percent lean mass. Two enzymes (alkaline phosphatase and serum glutamate oxaloacetate aminotransferase) and 29 metabolites were found to be significantly associated with the percent lean mass, including metabolites related to microbial metabolism, uremia, inflammation, oxidative stress, branched-chain amino acid metabolism, insulin sensitivity, glycerolipid metabolism, and xenobiotics. Use of sex-adjusted stepwise regression to obtain a final covariate predictor model identified the combination of 5 analytes and metabolites as overall predictors of the percent lean mass (model R = 82.5%). Collectively, these data suggest that a complex interplay of various metabolic processes underlies the maintenance of lean mass in young healthy adults.

  9. The intracellular transport and secretion of calumenin-1/2 in living cells.

    Directory of Open Access Journals (Sweden)

    Qiao Wang

    Full Text Available Calumenin isoforms 1 and 2 (calu-1/2, encoded by the CALU gene, belong to the CREC protein family. Calu-1/2 proteins are secreted into the extracellular space, but the secretory process and regulatory mechanism are largely unknown. Here, using a time-lapse imaging system, we visualized the intracellular transport and secretory process of calu-1/2-EGFP after their translocation into the ER lumen. Interestingly, we observed that an abundance of calu-1/2-EGFP accumulated in cellular processes before being released into the extracellular space, while only part of calu-1/2-EGFP proteins were secreted directly after attaching to the cell periphery. Moreover, we found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein. Finally, we determined the export signal of calu-1/2-EGFP (amino acid positions 20-46 and provided evidence that the asparagine at site 131 was indispensable for calu-1/2-EGFP stabilization. Taken together, we provide a detailed picture of the intracellular transport of calu-1/2-EGFP, which facilitates our understanding of the secretory mechanism of calu-1/2.

  10. Electrical and microstructural properties of CaTiO3-doped K1/2Na1/2NbO3-lead free ceramics

    Indian Academy of Sciences (India)

    L Ramajo; R Parra; M A Ramírez; M S Castro

    2011-10-01

    Microstructure, electrical properties and dielectric behaviour of K1/2Na1/2NbO3 (KNN) and CaTiO3- modified K1/2Na1/2NbO3 (CTO-KNN) systems, were investigated. Discs doped with 0 to 0.55% mol of CaTiO3 (CTO) were sintered at 1125°C for 2 h. Although minority phases were found in doped samples, CaTiO3 was not detected. It was also observed that CTO changed the microstructure and grain size of KNN drastically. Also, the Curie temperature and permittivity values decreased. Addition of CTO between 0.15 and 0.45 mol% decreases the density and dielectric values. Samples prepared with higher content of CTO than 0.45 mol% showed better electrical properties.

  11. Magnetic and ferroelectric orders in strained Gd{sub 1/2}Na{sub 1/2}TiO{sub 3}: First-principles calculations

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, P. X. [Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093 (China); School of Science, Nantong University, Nantong 226007 (China); Dong, S., E-mail: sdong@seu.edu.cn [Department of Physics, Southeast University, Nanjing 211189 (China); Xie, Y. L.; Yan, Z. B.; Zhou, X. H.; Liu, J.-M., E-mail: liujm@nju.edu.cn [Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093 (China)

    2015-05-07

    The emergent magnetic and ferroelectric orders in A-site ordered Gd{sub 1/2}Na{sub 1/2}TiO{sub 3} under lattice strain are investigated using the first-principles calculations. It is revealed that the lattice prefers the perovskite structure with alternatively stacked Ga-O and Na-O layers along the b-axis and the ground spin state favors the G-type antiferromagnetic (G-AFM) order. The ac-plane biaxial strain can remarkably tune the amplitude of ferroelectric polarization, while the G-AFM spin structure is robustly unaffected. The ±4% strains can trigger the change of polarization up to ±50% relative to the polarization value of unstrained structure. The present work suggests a possible scenario to control emergent multiferroic behaviors in Gd{sub 1/2}Na{sub 1/2}TiO{sub 3} via lattice strain.

  12. Dielectric relaxation in lead-free perovskite Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, K.; Bhagat, S.; Nath, K.A.; Choudhary, S.N. [Materials Research Laboratory, University Department of Physics, T. M. Bhagalpur University, Bhagalpur (India); Yadav, K.L. [Department of Physics, Indian Institute of Technology, Roorkee (India)

    2009-02-15

    A new lead-free perovskite ceramic Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3} was prepared by a conventional ceramic technique at 1185 C in oxygen atmosphere. X-ray diffraction analysis of the compound indicated the formation of a single-phase monoclinic structure. Dielectric study revealed a diffuse phase transition at 340 C. Cole-cole analyses suggested the dielectric relaxation to be of non-Debye type. Electric modulus studies supported the hopping type of conduction in Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3}. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  13. Tailoring the piezoelectric and relaxor properties of (Bi1/2 Na1/2) TiO3- BaTiO3 via zirconium doping

    DEFF Research Database (Denmark)

    Glaum, Julia; Simons, Hugh; Acosta, Matias

    2013-01-01

    This article details the influence of zirconium doping on the piezoelectric properties and relaxor characteristics of 94(Bi1/2Na1/2)TiO3-6Ba(ZrxTi1-x)O3 (BNT-6BZT) bulk ceramics. Neutron diffraction measurements of BNT-6BZT doped with 0%-15% Zr revealed an electric-field-induced transition...

  14. Immunohistochemical and western blot analysis suggest that the soluble forms of FGF1-2 and FGFR1-2 sustain tail regeneration in the lizard.

    Science.gov (United States)

    Alibardi, Lorenzo

    2017-08-18

    Fibroblast Growth Factors 1-2 (FGF1-2) stimulate tail regeneration in lizards and therefore the distribution of their receptors, FGFR1-2, in the regenerating tail of the lizard. Podarcis muralis has been studied using immunofluorescence and western blotting. Immunoreactive protein bands at 15-16kDa for FGF1-2 in addition to those at 50-65kDa are detected in the regenerating epidermis, but weak bands at 35, 45 and 50kDa appear from the regenerating connective tissues. Strongly immunolabeled bands for FGFR1 at 32, 60, and 80kDa and less intense for FGFR2 only appear in the regenerating tail. In normal tail epidermis and dermis, higher MW forms are present at 80 and 115-140kDa, respectively, but they disappear in the regenerating epidermis and dermis where low MW forms of FGFR1-2 are found at 50-70kDa. Immunolocalization confirms that most FGFR1-2 are present in the wound epidermis, Apical Epidermal Peg, ependymal tube while immunolabeling lowers in regenerating muscles, blastema cells, cartilage and connectives tissues. The likely release of FGFs from the Apical Epidermal Peg and ependyma and the presence of their receptors in these tissues may determine the autocrine stimulation of proliferation and a paracrine stimulation of the blastema cells through their FGF Receptors. Copyright © 2017 Elsevier GmbH. All rights reserved.

  15. Effect of substitution of titanium by magnesium and niobium on structure and piezoelectric properties in (Bi1/2Na1/2)TiO3 ceramics

    Indian Academy of Sciences (India)

    Zhou Chang-Rong; Liu Xin-Yu; Li Wei-Zhou; Yuan Chang-Lai

    2011-12-01

    To develop new (Bi1/2Na1/2)TiO3-based ceramics with excellent piezoelectric properties, the similarities and the differences between PZT and (Bi1/2Na1/2)TiO3 ceramics were analysed. Based on the analysis, a new (Bi1/2Na1/2)TiO3-based piezoelectric ceramic of B-site substitution of complex ions (Mg1/3Nb2/3)4+ for Ti4+ was prepared by a conventional ceramic technique, and the effect of complex ions (Mg1/3Nb2/3)4+ addition on the microstructure, dielectric and piezoelectric properties was investigated. The research results show that all compositions are mono-perovskite phase and the grain size increases with increasing content of (Mg1/3Nb2/3)4+. The piezoelectric constant $d_{33}$ first increases and then decreases, and electromechanical coupling factor $k_{p}$ varies insignificantly with increasing content of (Mg1/3Nb2/3)4+.

  16. Effect of substitution of titanium by magnesium and niobium on structure and piezoelectric properties in (Bi1/2Na1/2)TiO3 ceramics

    Indian Academy of Sciences (India)

    Zhou Chang-Rong; Liu Xin-Yu; Li Wei-Zhou; Yuan Chang-Lai

    2009-02-01

    To develop new (Bi1/2Na1/2)TiO3-based ceramics with excellent piezoelectric properties, the similarities and the differences between PZT and (Bi1/2Na1/2)TiO3 ceramics were analysed. Based on the analysis, a new (Bi1/2Na1/2)TiO3-based piezoelectric ceramic of B-site substitution of complex ions (Mg1/3Nb2/3)4+ for Ti4+ was prepared by a conventional ceramic technique, and effect of complex ions (Mg1/3Nb2/3)4+ addition on the microstructure, dielectric and piezoelectric properties was investigated. The results show that all compositions are mono-perovskite phase and the grain size increases with increasing content of (Mg1/3Nb2/3)4+. The piezoelectric constant, 33, first increases and then decreases, and electromechanical coupling factor, p, varies insignificantly with increasing content of (Mg1/3Nb2/3)4+.

  17. 正整数n-color 1-2有序分拆%n-color 1-2 compositions of positive integers

    Institute of Scientific and Technical Information of China (English)

    郭育红

    2015-01-01

    正整数的n-color 1-2有序分拆是指正整数的只含有分部量是1或者2的n-color有序分拆,而正整数的回文的n-color 1-2有序分拆是指只含有分部量是1或者2的n-color有序分拆且分部量从前往后读与从后往前读是相等的.这里给出了正整数的n-color 1-2有序分拆数和回文的n-color 1-2有序分拆数的生成函数、显式公式以及递推公式.而且还给出了正整数的n-color 1-2有序分拆数和回文的n-color 1-2有序分拆数之间的一个关系式.

  18. Percent Errors in the Estimation of Demand for Secondary Items.

    Science.gov (United States)

    1985-11-01

    percent errors, and the program change factor (PCF) to predict item demana during the procurement *’ leadtime (PROLT) ior the item. The PCF accounts for...type of demand it was. It may"-- have been demanded over two years ago or it may nave been a non-recurring demana . Since CC b only retains two years of...observed distributions could be compared with negative binomial distributions. For each item the computed ratio of actual demana to expected demand was

  19. The 50 percent solution to reducing energy costs.

    Science.gov (United States)

    Whitson, B Alan

    2012-11-01

    Hospitals can use a five-step process to achieve energy savings: Define a minimum acceptable ROI or hurdle rate. Seek incentives, rebates, and tax benefits. Set a 10-year investment horizon for all project portfolios. Create a system for tracking and reporting the operational and financial performance of the project portfolios. At the end of the year, return 50 percent of the savings to the facilities department and use the rest to fund additional projects.

  20. Intertemporal discoordination in the 100 percent reserve banking system

    OpenAIRE

    Baeriswyl, Romain

    2014-01-01

    The 100%-Money Plan advocated by Fisher (1936) has a Misesian flavor as it aims at mitigating intertemporal discoordination by reducing (i) the discrepancy between investment and voluntary savings, and (ii) the manipulation of interest rates by monetary injections. Recent proposals to adopt the 100 percent reserve banking system, such as the Chicago Plan Revisited by Benes and Kumhof (2013) or the Limited Purpose Banking by Kotlikoff (2010), take, however, a fundamentally different attitude t...

  1. Galaxy Clusters Around z 1-2 Low Luminosity Radio Galaxies

    Science.gov (United States)

    Castignani, Gianluca

    2017-07-01

    At variance with powerful radio galaxies Low Luminosity Radio Galaxies (LLRGs) are almost invariably found in clusters and often associated with the brightest cluster galaxies, at least at low-redshifts. In order to prove that this holds also at high-z we exploit a sample of 32 LLRGs at z 1-2 drawn from the COSMOS survey and search for Mpc-scale overdensities using photometric redshifts and our recently developed Poisson Probability Method. We find that 70% of the LLRGs reside in rich groups or (proto-)clusters. This fraction is higher than that found for powerful radio galaxies at similar redshifts and is in excellent agreement with results obtained at low redshifts. Independent confirmation of some of our cluster candidates is found in catalogs of clusters selected in X-rays or spectroscopically. Our strategy is unbiased with respect to colors and star formation history of cluster galaxies and represents a valuable alternative to conventional methods that search for clusters. We observed with the 30 m IRAM telescope two of our z = 1 LLRGs in clusters to search for molecular gas and set CO upper limits. Our clusters are optimal targets for mm observations with NOEMA and ALMA.

  2. New instrumentation for the 1.2m Southern Millimeter Wave Telescope (SMWT)

    Science.gov (United States)

    Vasquez, P.; Astudillo, P.; Rodriguez, R.; Monasterio, D.; Reyes, N.; Finger, R.; Mena, F. P.; Bronfman, L.

    2016-07-01

    Here we describe the status of the upgrade program that is being performed to modernize the Southern 1.2m Wave Telescope. The Telescope was built during early ´80 to complete the first Galactic survey of Molecular Clouds in the CO(1-0) line. After a fruitful operation in CTIO the telescope was relocated to the Universidad de Chile, Cerro Calán Observatory. The new site has an altitude of 850m and allows observations in the millimeter range throughout the year. The telescope was upgraded, including a new building to house operations, new control system, and new receiver and back-end technologies. The new front end is a sideband-separating receiver based on a HEMT amplifier and sub-harmonic mixers. It is cooled with Liquid Nitrogen to diminish its noise temperature. The back-end is a digital spectrometer, based on the Reconfigurable Open Architecture Computing Hardware (ROACH). The new spectrometer includes IF hybridization capabilities to avoid analog hybrids and, therefore, improve the sideband rejection ratio of the receiver.

  3. Isopachs of total net coal in beds >1.2' thick, A - G coal zones, Danforth Hills coal field (dan*thkg)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — These are shapefiles and ARC/INFO polygon coverages showing the isopachs of total net coal in beds greater than or equal to 1.2' thick for the A through G coal...

  4. Neural network wind retrieval from ERS -1/2 scatterometer data

    Institute of Scientific and Technical Information of China (English)

    LIN Mingsen; SONG Xingai; JIANG Xingwei

    2006-01-01

    A neural network methodology is presented to retrieve wind vectors from ERS - 1/2 scatterometer data. The wind directional ambiguities are eliminated by a circular median filter algorithm. All data come from ERS - 1/2 scatterometer data collocated pairs with CMCD4 vector. Comparing the results with CMCD4 and ECMWF wind vector,they agree well, which indicates that it is possible to extract wind vector from the ERS-1/2 scatterometer with the neural network method.

  5. Young tableaux and crystal base for U_q(osp(1|2n))

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Let Uq(osp(1|2n)) be the quantized enveloping superalgebra corresponding to the Lie superalgebra osp(1|2n). In terms of semistandard Young tableaux satisfying some additional conditions, a realization of crystal graph of finite-dimensional irreducible modules of Uq(osp(1|2n)) is given. Also, the generalized LittlewoodRichardson rule for tensor product of crystal graphs is established.

  6. Uptake and metabolism of the novel peptide angiotensin-(1-12 by neonatal cardiac myocytes.

    Directory of Open Access Journals (Sweden)

    Sarfaraz Ahmad

    Full Text Available BACKGROUND: Angiotensin-(1-12 [Ang-(1-12] functions as an endogenous substrate for the productions of Ang II and Ang-(1-7 by a non-renin dependent mechanism. This study evaluated whether Ang-(1-12 is incorporated by neonatal cardiac myocytes and the enzymatic pathways of ¹²⁵I-Ang-(1-12 metabolism in the cardiac myocyte medium from WKY and SHR rats. METHODOLOGY/PRINCIPAL FINDINGS: The degradation of ¹²⁵I-Ang-(1-12 (1 nmol/L in the cultured medium of these cardiac myocytes was evaluated in the presence and absence of inhibitors for angiotensin converting enzymes 1 and 2, neprilysin and chymase. In both strains uptake of ¹²⁵I-Ang-(1-12 by myocytes occurred in a time-dependent fashion. Uptake of intact Ang-(1-12 was significantly greater in cardiac myocytes of SHR as compared to WKY. In the absence of renin angiotensin system (RAS enzymes inhibitors the hydrolysis of labeled Ang-(1-12 and the subsequent generation of smaller Ang peptides from Ang-(1-12 was significantly greater in SHR compared to WKY controls. ¹²⁵I-Ang-(1-12 degradation into smaller Ang peptides fragments was significantly inhibited (90% in WKY and 71% in SHR in the presence of all RAS enzymes inhibitors. Further analysis of peptide fractions generated through the incubation of Ang-(1-12 in the myocyte medium demonstrated a predominant hydrolytic effect of angiotensin converting enzyme and neprilysin in WKY and an additional role for chymase in SHR. CONCLUSIONS/SIGNIFICANCE: These studies demonstrate that neonatal myocytes sequester angiotensin-(1-12 and revealed the enzymes involved in the conversion of the dodecapeptide substrate to biologically active angiotensin peptides.

  7. Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum

    Science.gov (United States)

    Williams, Michael R; Fuchs, Jason R; Green, John T; Morielli, Anthony D

    2012-01-01

    The potassium channel Kv1.2 alpha-subunit is expressed in cerebellar Purkinje cell (PC) dendrites where its pharmacological inhibition increases excitability (Khavandgar et al., 2005). Kv1.2 is also expressed in cerebellar basket cell (BC) axon terminals (Sheng et al., 1994), where its blockade increases BC inhibition of PCs (Southan and Robertson, 1998a). Secretin receptors are also expressed both in PC dendrites and BC axon terminals (reviewed in (Yuan et al.). The effect of secretin on PC excitability is not yet known, but, like Kv1.2 inhibitors, secretin potently increases inhibitory input to PCs (Yung et al., 2001). This suggests secretin may act in part by suppressing Kv1.2. Receptor-mediated endocytosis is a mechanism of Kv1.2 suppression (Nesti et al., 2004). This process can be regulated by protein kinase A (PKA) (Connors et al., 2008). Since secretin receptors activate PKA (Wessels-Reiker et al., 1993), we tested the hypothesis that secretin regulates Kv1.2 trafficking in the cerebellum. Using cell surface protein biotinylation of rat cerebellar slices, we found secretin decreased cell-surface Kv1.2 levels by modulating Kv1.2 endocytic trafficking. This effect was mimicked by activating adenylate cyclase (AC) with forskolin, and was blocked by pharmacological inhibitors of AC or PKA. Imaging studies identified the BC axon terminal and Purkinje cell dendrites as loci of AC-dependent Kv1.2 trafficking. The physiological significance of secretin regulated Kv1.2 endocytosis is supported by our finding that infusion into the cerebellar cortex of either the Kv1.2 inhibitor Tityustoxin-Kα, or of the Kv1.2 regulator secretin, significantly enhances acquisition of eyeblink conditioning in rats. PMID:22764231

  8. Percent Area of Sagebrush Habitat Within an 100-km Radius

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map was developed to examine multi-scale spatial relationships between percentage of sagebrush and other response variables of interest. A map of sagebrush in...

  9. Percent Area of Sagebrush Habitat Within an 5-km Radius

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map was developed to examine multi-scale spatial relationships between percentage of sagebrush and other response variables of interest. A map of sagebrush in...

  10. Percent Area of Sagebrush Habitat Within an 18-km Radius

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map was developed to examine multi-scale spatial relationships between percentage of sagebrush and other response variables of interest. A map of sagebrush in...

  11. Percent Area of Sagebrush Habitat Within an 50-km Radius

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map was developed to examine multi-scale spatial relationships between percentage of sagebrush and other response variables of interest. A map of sagebrush in...

  12. Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study

    DEFF Research Database (Denmark)

    Brohet, Richard M; Goldgar, David E; Easton, Douglas F

    2007-01-01

    oral contraceptive use and risk of breast cancer among BRCA1/2 carriers. PATIENTS AND METHODS In the International BRCA1/2 Carrier Cohort study (IBCCS), a retrospective cohort of 1,593 BRCA1/2 mutation carriers was analyzed with a weighted Cox regression analysis. Results We found an increased risk...... was found among BRCA1/2 mutation carriers that current use of oral contraceptives is associated with risk of breast cancer more strongly than is past use, as is found in the general population. However, duration of use, especially before first full-term pregnancy, may be associated with an increasing risk...

  13. Integrable quantum field theories with supergroup symmetries the $OSP(1\\/2)$ case

    CERN Document Server

    Saleur, H; Saleur, Hubert; Wehefritz-Kaufmann, Birgit

    2003-01-01

    As a step to understand general patterns of integrability in 1+1 quantum field theories with supergroup symmetry, we study in details the case of $OSP(1/2)$. Our results include the solutions of natural generalizations of models with ordinary group symmetry: the $UOSP(1/2)_{k}$ WZW model with a current current perturbation, the $UOSP(1/2)$ principal chiral model, and the $UOSP(1/2)\\otimes UOSP(1/2)/UOSP(1/2)$ coset models perturbed by the adjoint. Graded parafermions are also discussed. A pattern peculiar to supergroups is the emergence of another class of models, whose simplest representative is the $OSP(1/2)/OSP(0/2)$ sigma model, where the (non unitary) orthosymplectic symmetry is realized non linearly (and can be spontaneously broken). For most models, we provide an integrable lattice realization. We show in particular that integrable $osp(1/2)$ spin chains with integer spin flow to $UOSP(1/2)$ WZW models in the continuum limit, hence providing what is to our knowledge the first physical realization of a ...

  14. Ultrasonic methods for measuring liquid viscosity and volume percent of solids

    Energy Technology Data Exchange (ETDEWEB)

    Sheen, S.H.; Chien, H.T.; Raptis, A.C.

    1997-02-01

    This report describes two ultrasonic techniques under development at Argonne National Laboratory (ANL) in support of the tank-waste transport effort undertaken by the U.S. Department of Energy in treating low-level nuclear waste. The techniques are intended to provide continuous on-line measurements of waste viscosity and volume percent of solids in a waste transport line. The ultrasonic technique being developed for waste-viscosity measurement is based on the patented ANL viscometer. Focus of the viscometer development in this project is on improving measurement accuracy, stability, and range, particularly in the low-viscosity range (<30 cP). A prototype instrument has been designed and tested in the laboratory. Better than 1% accuracy in liquid density measurement can be obtained by using either a polyetherimide or polystyrene wedge. To measure low viscosities, a thin-wedge design has been developed and shows good sensitivity down to 5 cP. The technique for measuring volume percent of solids is based on ultrasonic wave scattering and phase velocity variation. This report covers a survey of multiple scattering theories and other phenomenological approaches. A theoretical model leading to development of an ultrasonic instrument for measuring volume percent of solids is proposed, and preliminary measurement data are presented.

  15. Research on the Lyophilization Technology of 1,2-Methylene Dichloride%1,2-二氯乙烷冷冻干燥工艺的研究

    Institute of Scientific and Technical Information of China (English)

    张金娜; 祁锦成; 朱春来

    2012-01-01

    1,2-二氯乙烷是一种常用的有机溶剂,在很多工业生产中作为溶剂时可重复使用,但在一些要求无水条件下进行反应的生产中,需对其回收后进行干燥,达到要求后方可使用.文章对二氯乙烷回收采用的冷冻干燥工艺进行研究.%1,2- methylene dichloride is a kind of common organic solvent and can be recycled in industrial production. But some reactions need it without any water. So it can be used only after it is reclaimed and dried. To recycle it, the lyophilization technology of 1,2 - methylene dichloride is researched in the article.

  16. Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue.

    Science.gov (United States)

    Parrino, Barbara; Spanò, Virginia; Carbone, Anna; Barraja, Paola; Diana, Patrizia; Cirrincione, Girolamo; Montalbano, Alessandra

    2014-08-29

    Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).

  17. Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue

    Directory of Open Access Journals (Sweden)

    Barbara Parrino

    2014-08-01

    Full Text Available Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA and four of them exhibited modest activity against MCF7 (a breast cancer cell line and/or UO-31 (a renal cancer cell line.

  18. The [17.0] 2Π1/2← X 2Π1/2 system of AlCa

    Science.gov (United States)

    Fabbi, Jacqueline C.; Langenberg, Jon D.; Morse, Michael D.

    2000-04-01

    Laser-induced fluorescence spectroscopy has been used to study supersonically cooled AlCa. This study investigates under higher resolution (0.007 cm-1) a single band previously studied and tentatively assigned as the (0-0) vibrational transition of the [17.0] 2Δ3/2(?)← X 2Π1/2 system of AlCa. The resolution of the rotational structure in the present study enabled a definite assignment as a 2Π1/2← 2Π1/2 transition. Analysis of the spectrum gives B0'=0.096685(19) cm-1, ( p+2 q)'=-0.013078(370) cm -1, and B0″=0.105518(20) cm -1. These convert to ground and excited state bond lengths of r0″=3.14942(30) and r0'=3.29014(32) Å, respectively.

  19. Electrochemical Reduction of 1,2-Di(p-tolylimino)ethane and 1,2-Di(2,4-dimethylphenylimino)ethane in Dimethylformamide

    Institute of Scientific and Technical Information of China (English)

    FOTOUHI, Lida; ZEIENALI, Mahbobeh; DEHGHANPOUR, Saeed; NEMATOLLAHI, Davood

    2007-01-01

    1,2-Di(p-tolylimino)ethane (Ⅰ) and 1,2-Di(2,4-dimethylphenylimino)ethane (Ⅱ) were synthesized and their electrochemical behavior investigated in dimethylformamide using classical voltammetry, differential pulse voltammetry, cyclic voltammetry, chronoamperometry, controlled potential electrolysis and coulometry. Both bis-Schiff base ligands examined show a cathodic irreversible peak which corresponds to one-electron reduction of the substrate to form anion radical. According to the fact obtained from cyclic voltammetry, that the current function(ip/v1/2) is a decreasing function of the scan rate, it can be concluded that there is a following coupling chemical reaction (EC mechanism). Thus, the most probable mechanism of electroreduction of both ligands is the coupling of two radicals to form a dimer.

  20. BRCA1/2-negative hereditary triple-negative breast cancers exhibit BRCAness.

    Science.gov (United States)

    Domagala, Pawel; Hybiak, Jolanta; Cybulski, Cezary; Lubinski, Jan

    2017-04-01

    BRCA1/2-associated breast cancers are sensitive to poly(ADPribose) polymerase (PARP) inhibitors and platinum compounds mainly due to their deficiency in DNA repair via homologous recombination (HR). However, approximately only 15% of triple-negative breast cancers (TNBCs) are BRCA1/2-associated. TNBCs that exhibit BRCAness (a phenotype reflecting impaired HR in BRCA1/2-negative tumors) are also regarded sensitive to PARP inhibitors and platinum compounds. Thus, we hypothesized that hereditary BRCA1/2-negative TNBCs may exhibit BRCAness. To find a subset of hereditary BRCA1/2-negative TNBCs among 360 TNBCs, we first identified a group of 41 hereditary TNBCs by analyzing the family histories of the patients. Next, we tested this group for the presence of germline BRCA1/2 mutations, and finally, we compared the expression levels of 120 genes involved in HR and five other major mechanisms of DNA damage repair between BRCA1/2-associated and BRCA1/2-negative subgroups of hereditary TNBCs using real-time PCR arrays. Approximately 73% of the hereditary TNBCs were BRCA1/2-associated and 27% were BRCA1/2-negative. The expression levels of the analyzed genes showed no significant differences between these two subgroups indicating the BRCAness of the BRCA1/2-negative hereditary TNBCs and thereby distinguishing a novel subset of TNBCs as a potential target for PARP inhibitors or platinum-based therapy. The results show the significance of family history in selecting patients with TNBC for therapies directed at incompetent DNA repair (e.g., PARP inhibitors and/or platinum-based therapies) and indicate that a relatively simple strategy for broadening the target group for these modes of treatment is to identify patients with hereditary TNBCs.

  1. Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene.

    Science.gov (United States)

    Tshala-Katumbay, Desire; Monterroso, Victor; Kayton, Robert; Lasarev, Michael; Sabri, Mohammad; Spencer, Peter

    2008-09-01

    Motor neuron axonopathy in diseases such as amyotrophic lateral sclerosis can be modeled and probed with neurotoxic chemicals that induce similar patterns of pathology, such as axonal spheroids that represent focal accumulation of anterogradely transported neurofilaments (NFs). The aromatic gamma-diketone-like 1,2-diacetylbenzene (1,2-DAB), but not its 1,3-DAB isomer, reacts with epsilon-amino- or sulfyhydryl groups of (neuro)proteins, forms adducts, and causes NFs to accumulate at proximal sites of elongate motor axons. We exploit the protein-reactive properties of neurotoxic 1,2-DAB versus the nonprotein-reactive properties of non-neurotoxic 1,3-DAB to unveil proteomic changes associated with this type of pathology. We used two-dimensional differential in-gel electrophoresis (2D-DIGE), matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry to analyze the lumbosacral spinal cord proteome of adult Sprague-Dawley rats treated systemically with 20 mg/kg/day 1,2-DAB, equimolar dose of 1,3-DAB, or equivalent volume of vehicle (saline containing 2% acetone), 5 days a week, for 2 weeks. 1,2-DAB significantly altered the expression of protein disulfide isomerase, an enzyme involved in protein folding, and gelsolin, an actin-capping and -severing protein. Modifications of these two proteins have been incriminated in the pathogenesis of nerve fiber degeneration. Protein-reactive and neurotoxic 1,2-DAB appears to be excellent tool to dissect mechanisms of nerve fiber (axon) degeneration.

  2. A 99 percent purity molecular sieve oxygen generator

    Science.gov (United States)

    Miller, G. W.

    1991-01-01

    Molecular sieve oxygen generating systems (MSOGS) have become the accepted method for the production of breathable oxygen on military aircraft. These systems separate oxygen for aircraft engine bleed air by application of pressure swing adsorption (PSA) technology. Oxygen is concentrated by preferential adsorption in nitrogen in a zeolite molecular sieve. However, the inability of current zeolite molecular sieves to discriminate between oxygen and argon results in an oxygen purity limitations of 93-95 percent (both oxygen and argon concentrate). The goal was to develop a new PSA process capable of exceeding the present oxygen purity limitations. A novel molecular sieve oxygen concentrator was developed which is capable of generating oxygen concentrations of up to 99.7 percent directly from air. The process is comprised of four absorbent beds, two containing a zeolite molecular sieve and two containing a carbon molecular sieve. This new process may find use in aircraft and medical breathing systems, and industrial air separation systems. The commercial potential of the process is currently being evaluated.

  3. LJ's 2010 Budget Survey: Bottoming Out?

    Science.gov (United States)

    Kelley, Michael

    2011-01-01

    In this article, the author presents the results of "Library Journal's" 2010 budget survey. The overall trend in FY10 indicated that 72 percent of survey respondents said their budget had been cut, and 43 percent had staff cuts. Among libraries serving populations above one million, these figures were even more acute, with 86 percent reporting…

  4. High resolution photoassociation spectra of an ultracold Cs2 long-range 0u+ (6S1/2 + 6P1/2) state

    Science.gov (United States)

    Chen, Peng; Li, Yu-Qing; Zhang, Yi-Chi; Wu, Ji-Zhou; Ma, Jie; Xiao, Lian-Tuan; Jia, Suo-Tang

    2013-09-01

    In this paper, ultracold cesium molecules are formed through photoassociation technology, which is carried out in a magneto-optical trap. High resolution photoassociaion spectra with the rotational progressions up to J = 7 are obtained. Three rovibrational levels of the long-range 0u+ state of Cs2 below the (6S1/2 + 6P1/2) dissociation limit are specifically investigated. By fitting their binding energy intervals to the non-rigid rotational model, the rotational constant of the long-range 0u+ state is determined. A proportional dependence of the value of the rotational constant on the vibrational quantum number is demonstrated.

  5. Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

    Science.gov (United States)

    Yamagata, Tetsushi; Ogiwara, Ikuo; Mazaki, Emi; Yanagawa, Yuchio; Yamakawa, Kazuhiro

    2017-09-30

    Nav1.1 and Nav1.2 are the voltage-gated sodium channel pore-forming alpha I and II subunits, encoded by the genes SCN1A and SCN2A. Although mutations of both genes have similarly been described in patients with epilepsy, autism and/or intellectual disability, their expression sites in brain are largely distinct. Nav1.1 was shown to be expressed dominantly in parvalbumin (PV)-positive or somatostatin (SST)-positive inhibitory neurons and in a sparsely-distributed subpopulation of excitatory neurons. In contrast, Nav1.2 has been reported to be dominantly expressed in excitatory neurons. Here we show that Nav1.2 is also expressed in caudal ganglionic eminence (CGE)-derived inhibitory neurons, and expressions of Nav1.1 and Nav1.2 are mutually-exclusive in many of brain regions including neocortex, hippocampus, cerebellum, striatum and globus pallidus. In neocortex at postnatal day 15, in addition to the expression in excitatory neurons we show that Nav1.2 is expressed in reelin (RLN)-positive/SST-negative inhibitory neurons that are presumably single-bouquet cells because of their cortical layer I-limited distribution, and vasoactive intestinal peptide (VIP)-positive neurons that would be multipolar cell because of their layer I/II margin and layer VI distribution. Although Nav1.2 has previously been reported to be expressed in SST-positive cells, we here show that Nav1.2 is not expressed in either of PV-positive or SST-positive inhibitory neurons. PV-positive and SST-positive inhibitory neurons derive from medial ganglionic eminence (MGE) and innervate excitatory neurons, while VIP-positive and RLN-positive/SST-negative inhibitory neurons derive from CGE, innervate on inhibitory neurons and play disinhibitory roles in the neural network. Our results therefore indicate that, while Nav1.1 is expressed in MEG-derived inhibitory neurons, Nav1.2 is expressed in CGE-derived disinhibitory interneurons in addition to excitatory neurons. These findings should contribute to understanding of the pathology of neurodevelopmental diseases caused by SCN2A mutations. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Synthesis, antiinflammatory and HIV-1 integrase inhibitory activities of 1,2-bis[5-thiazolyl]ethane-1,2-dione derivatives

    Directory of Open Access Journals (Sweden)

    Franklin P

    2009-01-01

    Full Text Available Based on principles of pharmacophore delineation and drug designing, compounds containing diketofunctionallity namely 1,2-bis[5-thiazolyl]ethane-1,2-diones were designed and synthesized as antiinflammatory agents. The compounds were evaluated in carrageenan-induced rat-paw edema method. G-3, G-6, G-17, G-20, G-23, G-22, L-708 and 906 showed good antiinflammatory activity. In addition as diketo functionality containing compounds are reported to have HIV-1 integrase inhibitory property, and these compounds contains diketo functionality, so these compounds were screened in assay for HIV-1 integrase inhibition. Few compounds showed weak HIV-1 integrase Inhibitory activity.

  7. Vanadium(III chloride complexes of 1,2-bis-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl-1,2-ethanediols

    Directory of Open Access Journals (Sweden)

    AYDIN TAVMAN

    2006-05-01

    Full Text Available The complexes of 1,2-bis-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl-1,2-ethanediols (L1-L4 with VCl3 were synthesized and characterized by elemental analyses, molar conductivity, FTIR and 1H-NMR spectroscopy. The ligands act as bidentate coordinating through both of the hydroxyl group oxygen atoms in the complexes. The ionic and diamagnetic complexes have the empirical formula [V(L2]Cl3. The [V(L42]Cl3 complex has two isomeric structures according to the 1H-NMR spectral data.

  8. Two-point spin-1/2-spin-1/2 sl(2,bfC) conformal Kac-Moody blocks on the torus and their monodromies

    Energy Technology Data Exchange (ETDEWEB)

    Smyrnakis, J.M. [Columbia Univ., New York, NY (United States). Dept. of Mathematics

    1995-10-02

    Two issues of the SU(2) Wess-Zumino-Witten model are examined here, namely the computation of the untwisted conformal Kac-Moody blocks on the torus and their monodromy representations. Using the free field representation developed by Bernard and Felder, an integral representation of the twisted two point spin-1/2-spin-1/2 conformal Kac-Moody blocks on the torus is computed. From this, an integral representation of the untwisted blocks is computed after careful removal of infinities. Finally, the untwisted blocks are used to get a representation of the Braid Group on the torus on two strings, in terms of quantum group q-numbers. (orig.).

  9. Purification and characterization of an alcohol dehydrogenase from 1,2-propanediol-grown Desulfovibriostrain HDv

    NARCIS (Netherlands)

    Hensgens, Charles M.H.; Jansen, Michael; Nienhuis-Kuiper, Manny E.; Boekema, Egbert J.; Breemen, Jan F.L. van; Hansen, Theo A.

    1995-01-01

    The sulfate-reducing bacterium Desulfovibrio strain HDv (DSM 6830) grew faster on (S)- and on (R, S)-1,2-propanediol (µmax 0.053 h–1) than on (R)-propanediol (0.017 h–1) and ethanol (0.027 h–1). From (R, S)-1,2-propanediol-grown cells, an alcohol dehydrogenase was purified. The enzyme was

  10. Degradation of 1,2-Dibromoethane by Mycobacterium sp. Strain GP1

    NARCIS (Netherlands)

    Poelarends, Gerrit J.; Hylckama Vlieg, Johan E.T. van; Marchesi, Julian R.; Freitas dos Santos, Luisa M.; Janssen, Dick B.

    1999-01-01

    The newly isolated bacterial strain GP1 can utilize 1,2-dibromoethane as the sole carbon and energy source. On the basis of 16S rRNA gene sequence analysis, the organism was identified as a member of the subgroup which contains the fast-growing mycobacteria, The first step in 1,2-dibromoethane metab

  11. Novel Platinum Catalyzed Glycosylation Using 1,2-Cyclopropanated Sugars as Glycosyl Donors

    DEFF Research Database (Denmark)

    Beyer, Jürgen; Madsen, Robert

    1998-01-01

    By treating 1,2-cyclopropanated sugars with Zeise's dimer and an alcohol a regioselective ring opening of the cyclopropane takes place to give 2-C-alkyl-2-deoxy-glycosides......By treating 1,2-cyclopropanated sugars with Zeise's dimer and an alcohol a regioselective ring opening of the cyclopropane takes place to give 2-C-alkyl-2-deoxy-glycosides...

  12. Metallothionein-1+2 protect the CNS after a focal brain injury

    DEFF Research Database (Denmark)

    Giralt, Mercedes; Penkowa, Milena; Lago, Natalia;

    2002-01-01

    We have evaluated the physiological relevance of metallothionein-1+2 (MT-1+2) in the CNS following damage caused by a focal cryolesion onto the cortex. In comparison to normal mice, transgenic mice overexpressing the MT-1 isoform (TgMTI* mice) showed a significant decrease of the number of activa...

  13. Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide

    DEFF Research Database (Denmark)

    Penkowa, Milena; Giralt, Mercedes; Camats, Jordi

    2002-01-01

    6-Aminonicotinamide (6-AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes. Metallothionein 1+2 (MT-1+2) are neuroprotective factors in the central nervous system (CNS), and to determine the roles for MT after 6-AN, we have examined transgenic mice overexpressing MT-1...

  14. 7 CFR 1.12 - Handling information from a private business.

    Science.gov (United States)

    2010-01-01

    ... is not exempt by law from disclosure). Afford business information submitter reasonable time in which... 7 Agriculture 1 2010-01-01 2010-01-01 false Handling information from a private business. 1.12... Records § 1.12 Handling information from a private business. Each USDA agency is responsible for...

  15. 26 CFR 1.412(c)(1)-2 - Shortfall method.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Shortfall method. 1.412(c)(1)-2 Section 1.412(c... (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.412(c)(1)-2 Shortfall method. (a) In general—(1) Shortfall method. The shortfall method is a funding method that adapts a...

  16. Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine.

    Science.gov (United States)

    Li, Wenjie; Nelson, Dorian P; Jensen, Mark S; Hoerrner, R Scott; Javadi, Gary J; Cai, Dongwei; Larsen, Robert D

    2003-12-11

    Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text

  17. CaV1.2 calcium channels: just cut out to be regulated?

    Science.gov (United States)

    Groth, Rachel D; Tirko, Natasha N; Tsien, Richard W

    2014-06-04

    Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

  18. Canonical osp(1,2) quantization of dynamical systems with constraints

    CERN Document Server

    Lavrov, P M; Oliveira, W; Lavrov, Petr M.; Neto, Jorge Ananias; Oliveira, Wilson

    1998-01-01

    The canonical version of osp(1,2) quantization is formulated for arbitrary dynamical systems with first-class constraints. The formalism generalizes the canonical scheme of extended BRST quantization proposed by Batalin, Lavrov and Tyutin a few years ago. The gauge dependence of Green's functions is studied. The Ward identities related to the osp(1,2) symmetry are derived.

  19. Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries

    DEFF Research Database (Denmark)

    Ferrandi, Erica Elisa; Sayer, Christopher; Isupov, Michail N.;

    2015-01-01

    The epoxide hydrolases (EHs) represent an attractive option for the synthesis of chiral epoxides and 1,2-diols which are valuable building blocks for the synthesis of several pharmaceutical compounds. A metagenomic approach has been used to identify two new members of the atypical EH limonene-1,2...

  20. Genaesthics : Breast Surgery in BRCA1/2 Gene Mutation Carriers

    NARCIS (Netherlands)

    V.M.T. van Verschuer (Victorien)

    2017-01-01

    markdownabstractThe present thesis focuses on breast surgery in BRCA1/2 gene mutation carriers. The topics that are studied vary broadly, representing the multiple disciplines that are involved in the diagnostic work-up and treatment of BRCA1/2-associated breast cancer. The first part contains

  1. [1,2-Bis(dicyclohexylphosphanyl-1,2-dicarba-closo-dodecaborane-2κ2P,P′]di-μ-chlorido-1:2κ4Cl:Cl-dichlorido-1κ2Cl-dimercury(II

    Directory of Open Access Journals (Sweden)

    Liguo Yang

    2014-04-01

    Full Text Available The title compound, [Hg2Cl4(C26H54B10P2], was synthesized by the reaction of 1,2-bis(dicyclohexylphosphanyl-1,2-dicarba-closo-dodecaborane with HgCl2. Both HgII atoms show a distorted tetrahedral coordination geometry, provided by the two bridging chloride anions and the P atoms of the diphosphanyl ligand for one metal atom, and by two bridging and two terminal chloride anions for the other. The five-membered HgP2C2 chelate ring assumes an envelope conformation, with the HgII atom displaced by 0.1650 (5 Å from the mean plane of the other four atoms (r.m.s. deviation = 0.002 Å. In the crystal, B—H...Cl interactions link the molecules, forming a supramolecular chain along the a-axis direction.

  2. Multicentric evaluation of a new assay for prothrombin fragment F1+2 determination.

    Science.gov (United States)

    Bruhn, H D; Conard, J; Mannucci, M; Monteagudo, J; Pelzer, H; Reverter, J C; Samama, M; Tripodi, A; Wagner, C

    1992-10-01

    A multicenter study of a recently developed ELISA for the determination of prothrombin fragment F1+2 was performed in order to evaluate analytical and clinical aspects. Mean intra-assay and inter-assay reproducibility were found to be 11.0 and 12.6%, respectively. The measuring range covered by the calibration curve reaches from 0.04 to 10.0 nM/l F1+2. Testing 133 healthy subjects a reference range of 0.37 to 1.11 nM/l F1+2 (2.5-97.5 percentile) with a median of 0.66 nM/l F1+2 was calculated. Minor difficulties with blood sampling (venous occlusion for 2 min) did not affect F1+2 plasma concentrations. Significantly increased F1+2 levels were measured in patients with leukemia (p < 0.0001), severe liver disease (p < 0.005) and after myocardial infarction (p < 0.01). Elevated F1+2 concentration before the beginning of heparin therapy (1.25 nM/l) decreased to 0.77 nM/l (p < 0.0001) after 1 day of therapy. For patients in the stable phase of oral anticoagulant therapy decreasing F1+2 concentrations were measured with increasing INR. F1+2 levels were already significantly reduced in patients with INR < 2.0 (0.56 nM/l; p = 0.0005). Thus F1+2 determination may be helpful in identifying activation processes as well as in monitoring anticoagulant therapy.

  3. Predicting feedstock and percent composition for blends of biodiesel with conventional diesel using chemometrics and gas chromatography-mass spectrometry.

    Science.gov (United States)

    Schale, Stephen P; Le, Trang M; Pierce, Karisa M

    2012-05-30

    The two main goals of the analytical method described herein were to (1) use principal component analysis (PCA), hierarchical clustering (HCA) and K-nearest neighbors (KNN) to determine the feedstock source of blends of biodiesel and conventional diesel (feedstocks were two sources of soy, two strains of jatropha, and a local feedstock) and (2) use a partial least squares (PLS) model built specifically for each feedstock to determine the percent composition of the blend. The chemometric models were built using training sets composed of total ion current chromatograms from gas chromatography-quadrupole mass spectrometry (GC-qMS) using a polar column. The models were used to semi-automatically determine feedstock and blend percent composition of independent test set samples. The PLS predictions for jatropha blends had RMSEC=0.6, RMSECV=1.2, and RMSEP=1.4. The PLS predictions for soy blends had RMSEC=0.5, RMSECV=0.8, and RMSEP=1.2. The average relative error in predicted test set sample compositions was 5% for jatropha blends and 4% for soy blends. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Structural and electrical properties of Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Nishant [Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Dutta, Alo, E-mail: alo_dutta@yahoo.com [Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700009 (India); Prasad, S. [Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Sinha, T.P. [Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700009 (India)

    2012-01-15

    Highlights: > The Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3} (GNZ) ceramic is synthesized by the solid-state reaction technique. > Frequency dependence dielectric dispersion is studied in a wide temperature range. > Activation energy of 1.1 eV indicates hopping of ions and may be responsible for the dielectric relaxation. > The frequency dependent conductivity spectra follow the power law. - Abstract: The Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3} (GNZ) ceramic is synthesized by the solid-state reaction technique. The X-ray diffraction pattern of the sample shows monoclinic phase at room temperature. The dielectric dispersion of the material is investigated in the temperature range from 303 K to 673 K and in the frequency range from 100 Hz to 1 MHz. The relaxation peak is observed in the frequency dependence of the loss tangent. The relaxation time at different temperatures is found to obey Arrhenius law having activation energy of 1.1 eV which indicates the hopping of ions at the lattice site and may be responsible for the dielectric relaxation of GNZ. The scaling behaviour of loss tangent suggests that the relaxation mechanism is temperature independent. The frequency dependent conductivity spectra follow the power law. In the impedance formalism, the Cole-Cole model is used to study the relaxation mechanism of GNZ.

  5. Impedance and a.c. conductivity studies of Ba(Pr1/2Nb1/2)O3 ceramic

    Indian Academy of Sciences (India)

    K Amar Nath; K Prasad; K P Chandra; A R Kulkarni

    2013-08-01

    Impedance and electrical conduction studies of Ba(Pr1/2Nb1/2)O3 ceramic prepared through conventional ceramic fabrication technique are presented. The crystal symmetry, space group and unit cell dimensions were estimated using Rietveld analysis. X-ray diffraction analysis indicated the formation of a single-phase cubic structure with space group, $\\bar{3}$. EDAX and SEM studies were carried out to study the quality and purity of compound. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were presented using impedance data. Complex impedance as well as electric modulus analyses suggested dielectric relaxation to be of non-Debye type and negative temperature coefficient of resistance character. The correlated barrier hopping model was employed to successfully explain the mechanism of charge transport in Ba(Pr1/2Nb1/2)O3. The a.c. conductivity data were used to evaluate density of states at Fermi level, minimum hopping length and apparent activation energy.

  6. Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells.

    Science.gov (United States)

    Lee, Eun Kyeong; Kim, Jin-Ah; Park, Seong Joon; Kim, Jeung Ki; Heo, Kyu; Yang, Kwang Mo; Son, Tae Gen

    2013-05-01

    In the current study, we explored the effect of LDR on the activation of Nrfs transcription factor involved in cellular redox events. Experiments were carried out utilizing 0.05 and 0.5 Gy X-ray irradiated normal human skin fibroblast HS27 cells. The results showed LDR induced Nrf1 and Nrf2 activation and expression of antioxidant genes HO-1, Mn-SOD, and NQO1. In particular, 0.05 Gy-irradiation increased only Nrf1 activation, but 0.5 Gy induced both Nrf1 and Nrf2 activation. LDR-mediated Nrf1/2 activation was accompanied by reactive species (RS) generation and Ca(2+) flux. This effect was abolished in the presence of N-acetyl-cysteine and BAPTA- AM. Furthermore, Nrf1/2 activation by LDR was suppressed by PD98059, an inhibitor of ERK1/2. In conclusion, LDR induces Nrf1 and Nrf2 activation and expression of Nrf-regulated antioxidant defense genes through RS and Ca(2+)/ERK1/2 pathways, suggesting new insights into the molecular mechanism underlying the beneficial role of LDR in HS27 cells.

  7. Structural and dielectric studies of lead-free ceramics: Na1/2Y1/2TiO3

    Science.gov (United States)

    Barik, Subrat; Choudhary, Ram; Mahapatra, Prasanta

    2008-12-01

    The polycrystalline samples of Na1/2Y1/2TiO3 were prepared by the mixed-oxide method. A preliminary X-ray structural analysis was shown to exhibit the formation of a single-phase compound with an orthorhombic structure. Microstructural analysis by scanning electron microscopy (SEM) exhibits well defined grains distributed uniformly through out the sample suggesting the compactness and homogeneity of the sample. Detailed studies of dielectric properties of Na1/2Y1/2TiO3 in a wide frequency range (102-106 Hz) at different temperatures (31-500°C) show a dielectric anomaly at 105°C, which may be related to a ferroelectricparaelectric phase transition as suggested by hysteresis loop at room temperature. An ac conductivity (σ ac) of the material is mainly governed by the polaron hopping mechanism, which is also influenced by both frequency and temperature. The activation energy was obtained from the plot of temperature with a.c. conductivity.

  8. [Research of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acid derivatives].

    Science.gov (United States)

    Anisimova, V A; Tolpygin, I E; Spasov, A A; Serdiuk, T S; Sukhov, A G

    2011-01-01

    Ethyl esters of (9-subtituted-imidazo[1,2-a]benzimidazolyl-2)acetic acids were synthesized. The chemical properties of these esters (hydrolysis, decarboxylation, hydrazinolysis) and biological activity (fungicidal, antimicrobial, antiarrhythmic activity, and also affects on the brain rhythmogenesis) of the prepared compounds were studied.

  9. Formation of ultracold LiRb molecules by photoassociation near the Li(2s 2S1/2) + Rb(5p 2P1/2) asymptote

    Science.gov (United States)

    Dutta, Sourav; Elliott, Daniel S.; Chen, Yong P.

    2013-12-01

    We report the production of ultracold 7Li85Rb molecules by photoassociation (PA) below the Li (2s 2S1/2) + Rb(5p 2P1/2) asymptote. We perform PA spectroscopy in a dual-species 7Li-85Rb magneto-optical trap (MOT) and detect the PA resonances using trap loss spectroscopy. We observe several strong PA resonances corresponding to the last few bound states, assign the lines and derive the long-range C6 dispersion coefficients for the Li (2s 2S1/2) + Rb(5p 2P1/2) asymptote. We also report an excited-state molecule formation rate (P_{\\textit{LiRb}}) of {\\sim}10^{7}\\ \\text{s}^{-1} and a PA rate coefficient (K_{PA}) of {\\sim}4\\times10^{-11}\\ \\text{cm}^3/\\text{s} , which are both among the highest observed for heteronuclear bi-alkali molecules. These suggest that PA is a promising route for the creation of ultracold ground-state LiRb molecules.

  10. Formation of ultracold LiRb molecules by photoassociation near the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote

    CERN Document Server

    Dutta, Sourav; Chen, Yong P

    2013-01-01

    We report the production of ultracold 7Li85Rb molecules by photoassociation (PA) below the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote. We perform PA spectroscopy in a dual-species 7Li-85Rb magneto-optical trap (MOT) and detect the PA resonances using trap loss spectroscopy. We observe several strong PA resonances corresponding to the last few bound states, assign the lines and derive the long range C6 dispersion coefficients for the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote. We also report an excited-state molecule formation rate (P_LiRb) of ~10^7 s^-1 and a PA rate coefficient (K_PA) of ~4x10^-11 cm^3/s, which are both among the highest observed for heteronuclear bi-alkali molecules. These suggest that PA is a promising route for the creation of ultracold ground state LiRb molecules.

  11. Original Reaction Sequence of Pb(Yb1/2Nb1/2O3-PbTiO3: Consequences on Dielectric Properties and Chemical Order

    Directory of Open Access Journals (Sweden)

    Charlotte Cochard

    2015-01-01

    Full Text Available The solid solution [Pb(Yb1/2Nb1/2O3]1−x-[PbTiO3]x was synthesized with x≤60%, using several high-temperature techniques as well as room-temperature mechanosynthesis. The high-temperature synthesis reveals a reaction path involving the synthesis first of the end-members before the solid solution. The density and dielectric constant measured on the ceramics prepared from these powders indicate the crucial role of the synthesis technique in the subsequent properties. Mechanosynthesis results in ceramics with higher density and dielectric constant. Identical optimized sintering conditions were then applied to all investigated compositions and the resulting dielectric properties and chemical orders were compared. All polar orders (antiferroelectricity, ferroelectricity, and relaxor behavior were evidenced. The 1 : 1 chemical order on the B-site of Pb(Yb1/2Nb1/2O3 results in the formation of a double perovskite Pb2YbNbO6, and the superstructures in the X-ray diagrams signing the existence of this order persist up to 30% PbTiO3. The underlying mechanism for substitution of Yb or Nb by Ti is presented.

  12. Western blot seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2 in Fortaleza (Brazil: a serological and molecular diagnostic and epidemiological approach

    Directory of Open Access Journals (Sweden)

    Terezinha de Jesus Teixeira Santos

    2003-06-01

    Full Text Available How to handle Western blot (WB seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2 constitutes a challenge for blood banks and fam ilies. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA reactive individuals from the hematological center (HEMOCE of Fortaleza (Brazil, examining their serological (WB and molecular (PCR diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22% were positive and 32 (78% were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis and IDU.

  13. 合成1,2-环十二二酮的新方法%A Novel Synthetic Method of 1,2-Cyclododecandione

    Institute of Scientific and Technical Information of China (English)

    陈韶蕊; 马吉海; 周雪琴; 刘东志

    2009-01-01

    1,2-Cyclododecandione (4) was synthesized from dodecanedioic acid via esterification, acyloin condensation, oxidation in an overall yield of 43. 1 %. Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86. 5%. Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63. 1% , which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%. The target compound was a light yellow crystal and was characterized by means of IR, ~1H NMR and ~(I3)C NMR.%以十二烷二酸(1)为原料,与甲醇酯化生成十二烷二酸二甲酯(2),收率为86.5%.化合物2经偶联缩合得1,2-二三甲基硅氧基环十二烯(3),收率为63.1%. 利用溴氧化化合物3得到1,2-环十二二酮(4)淡黄色晶体,收率79%,全过程收率达43.1%,是合成1,2-二酮的新方法. 目标化合物结构经红外光谱、核磁共振氢谱和碳谱表征确认.

  14. Fragmento 1+2 da protrombina em indivíduos submetidos à angiografia coronariana Prothrombin fragment 1+2 in subjects undergoing coronary angiography

    Directory of Open Access Journals (Sweden)

    Luciana M. Lima

    2005-09-01

    Full Text Available A trombina exerce um papel fundamental na conversão do fibrinogênio em fibrina, no processo de coagulação. O fator X ativado transforma a protrombina em trombina e fragmento 1+2 da protrombina (F1+2. Os níveis plasmáticos de F1+2 refletem a geração de trombina e podem ser usados como um marcador de hipercoagulabilidade in vivo, já que a trombina é uma substância instável e facilmente degradada, que não pode ser medida diretamente no plasma. O presente estudo teve como objetivo determinar os níveis plasmáticos do F1+2 de um grupo de indivíduos submetidos à angiografia coronariana, buscando estabelecer a possível correlação entre este parâmetro e a gravidade da doença arterial coronariana (DAC. Os níveis plasmáticos do F1+2 foram determinados em amostras de sangue de 17 indivíduos com ausência de ateromatose nas coronárias (controles, 12 indivíduos apresentando ateromatose leve/moderada e 28 indivíduos apresentando ateromatose grave, utilizando-se o conjunto diagnóstico Enzignost F1+2 (Behring® Diagnostics GmbH, Marburg, Germany. Não foram encontradas diferenças estatisticamente significativas entre as médias dos três grupos para o parâmetro avaliado. Portanto, as médias obtidas nos três grupos para os níveis plasmáticos de F1+2 não sinalizam para a existência de um estado de hipercoagulabilidade na população estudada. Entretanto, 73,7% dos indivíduos faziam uso regular de ácido acetilsalicílico, o que pode ter influenciado nos resultados de F1+2, uma vez que este medicamento promove a inibição da enzima ciclooxigenase, diminuindo a liberação de tromboxane A2 e a agregação plaquetária. Portanto, presume-se que a redução da ativação plaquetária poderia estar contribuindo para uma menor formação de trombina e, conseqüentemente, diminuindo o potencial de hipercoagulabilidade.Thrombin plays a basic role in the conversion of fibrinogen to fibrin in the coagulation process. Activated factor X transforms the prothrombin into thrombin and breaks up prothrombin fragment 1+2 (F1+2. F1+2 plasma levels reflect the thrombin generation and can be used as in vivo markers of hypercoagulability since the thrombin is an unstable and easily degraded substance that cannot be directly measured in the plasma. The present study aims at determining the F1+2 plasma levels of a group of subjects undergoing coronary angiography, attempting to establish a possible correlation between this parameter and the severity of the coronary artery disease. F1+2 plasma levels were determined in blood samples of 17 subjects with absence of atheromatosis in coronary arteries (controls, 12 subjects presenting mild/moderate atheromatosis and 28 subjects presenting severe atheromatosis, using the Enzignost F1+2 (Behring® Diagnostics GmbH, Marburg, Germany diagnostic Kit. Significant differences between the averages for the three groups in respect to the evaluated parameters were not found. Therefore, F1+2 plasma level averages for the three groups did not point to a state of hypercoagulability in the studied population. However, 73.7% of the individuals were taking acetylsalicylic acid, which may have influenced the F1+2 plasma levels, considering that this medicine promotes the inhibition of the enzyme cyclo-oxygenase, diminishing the release of thromboxane A2 and the platelet aggregation. Therefore, it is presumed that platelet activation reduction could be contributing to a lower formation of thrombin and, consequently, diminishing the hypercoagulability potential.

  15. Systolic Pressure in Different Percents of Stenosis at Major Arteries

    CERN Document Server

    Mirzaee, Mohammad Reza; Firoozabadi, Bahar; Dandaneband, Meitham

    2016-01-01

    - Modeling Human cardiovascular system is always an important issue. One of the most effective methods is using lumped model to reach to a complete model of human cardiovascular system. Such modeling with advanced considerations is used in this paper. Some of these considerations are as follow: Exact simulating of ventricles as pressure suppliers, peristaltic motion of descending arteries as additional suppliers, and dividing each vessel into more than one compartment to reach more accurate answers. Finally a circuit with more than 150 RLC segments and different elements is made. Then the verification of our complex circuit is done and at the end, obstruction as an important abnormality is investigated. For this aim different percents of obstruction in vital arteries are considered and the results are brought as different graphs at the end. According to physiological texts the citation of our simulation and its results are obvious. To earn productive information about arteries characteristics a 36-vessels mod...

  16. One Percent Strömvil Photometry in M 67

    Science.gov (United States)

    Philip, A. G. D.; Boyle, R. P.; Janusz, R.

    2005-05-01

    The Vatican Advanced Technology Telescope on Mt. Graham is being used in a program of CCD photometry of open and globular clusters. We are using the Ströomvil System (Straižys et al. 1996), a combination of the Strömgren and Vilnius Systems. This system allows stars to be classified as to temperature, surface gravity, metallicity and reddening from the photometric measures alone. However, to make accurate estimates of the stellar parameters the photometry should be accurate to 1 or 1.5 percent. In our initial runs on the VATT we did not achieve this accuracy. The problem turned out to be scattered light in the telescope and this has now been reduced so we can do accurate photometry. Boyle has written a routine in IRAF which allows us to correct the flats for any differences. We take rotated frames and also frames which are offset in position by one third of a frame, east-west and north-south. Measures of the offset stars give us the corrections that need to be made to the flat. Robert Janusz has written a program, the CommandLog, which allows us to paste IRAF commands in the correct order to reduce measures made on a given observing run. There is an automatic version where one can test various parameters and get a set of solutions. Now we have a set of Strömvil frames in the open cluster, M 67 and we compare our color-magnitude diagram with those of BATC (Fan et al. 1996) and Vilnius (Boyle et al. 1998). A preliminary report of the M 67 photometry will be found in Laugalys et al. (2004). Here we report on a selected set of stars in the M 67 frames, those with errors 1 percent or less.

  17. Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration

    Indian Academy of Sciences (India)

    J. W. Li; G. P. Wang; J. Y. Fan; C. F. Chang; C. S. Xu

    2011-12-01

    Although it is known that hormones, growth factors and integrin promote hepatocyte proliferation in liver regeneration (LR) through ERK1/2 signalling pathway, reports about regulating processes of its intracellular paths in hepatocytes of LR are limited. This study aims at exploring which paths of ERK1/2 signalling pathway participate in the regulation of rat LR, especially in hepatocyte proliferation, and how they do so. In all, 14 paths and 165 genes are known to be involved in ERK1/2 signalling pathway. Of them, 161 genes are included in Rat Genome 230 2.0 Array. This array was used to detect expression changes of genes related to ERK1/2 signalling pathway in isolated hepatocytes of rat LR, showing that 60 genes were related to hepatocytes of LR. In addition, bioinformatics and systems biology methods were used to analyse the roles of 14 above paths in regenerating hepatocytes. We found that three paths, RTK → SHC → GRB2/SOS → RAS → RAF, Integrin → FAK → RAC → PAK → RAF and G → PI3K → RAC → PAK → RAF, promoted the G1 phase progression of hepatocytes by activating ERK1/2. A further four paths, Gq → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, RTK → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, Integrin → FAK/SRC → GRB2/SOS → RAS → RAF and Integrin → FAK → RAC → PAK → RAF, advanced the cell progression of S phase and G2/M checkpoint by activating ERK1/2, and so did PP1/2 → Mek1/2 by decreasing the negative influence on ERK1/2. At the late phase of LR, Gs → AC → EPAC → Rap1 → Raf blocked hepatocyte proliferation by decreasing the activity of ERK1/2 and so did PP1/2 → Mek1/2. In summary, 60 genes and 8 paths of ERK1/2 signalling pathway regulated hepatocyte proliferation in rat LR.

  18. Características produtivas e reprodutivas de fêmeas da raça Nelore e cruzadas 1/2 Canchim + 1/2 Nelore Productive and reproductive traits of straightbred Nellore and crossbred 1/2 Canchim + 1/2 Nellore Females

    Directory of Open Access Journals (Sweden)

    Alencar

    1999-01-01

    Full Text Available O objetivo deste estudo foi avaliar os efeitos de fatores de meio e genéticos sobre o peso ao parto (PVP de vacas Nelore e 1/2 Canchim + 1/2 Nelore, acasaladas com touros das raças Canchim e Charolesa, respectivamente, e também sobre o período de gestação (PG de seus bezerros e sobre os pesos (P e as idades (I à primeira inseminação (PI, primeira concepção (PC e primeira parição (PP das novilhas 1/2Canchim + 1/2 Nelore. O método dos quadrados mínimos foi usado com modelos matemáticos que incluíram os efeitos de ano e mês do parto, idade da vaca ao parto e origem da vaca (para as vacas Nelore para a análise de PVP, estação de monta, idade da vaca, origem da vaca, sexo do bezerro e os efeitos aleatórios de pai do bezerro, para a análise de PG, e ano e época de nascimento e a interação ano x época, para as características das novilhas. Ano do parto e origem da vaca apresentaram efeito sobre PVP. As vacas paridas de agosto a novembro foram mais leves ao parto que as paridas em dezembro e de maio a julho. O peso ao parto aumentou linearmente com a idade da vaca. O PG dos machos foi maior que o das fêmeas, para os bezerros 1/2 Canchim + 1/2 Nelore. As médias estimadas de PVP foram iguais a 450±2 kg (vacas Nelore e 502±2 kg (vacas 1/2 Canchim + 1/2 Nelore e as de PG, 291,0 ± 0,4 dias (bezerros 1/2 Canchim + 1/2 Nelore e 285,7± 0,2 dias (bezerros 1/2 Charolês + 1/4 Canchim + 1/4 Nelore. Para as novilhas cruzadas, as médias estimadas foram iguais a 372±2 kg (PPI, 376±2 kg (PPC, 442±3 kg (PPP, 810±5 dias (IPI, 831±6 dias (IPC e 1116±6 dias (IPP. As herdabilidades de PG, como característica do bezerro, foram iguais a 0,19±0,14 (1/2 Canchim + 1/2 Nelore e 0,69±0,31 (1/2 Charolês + 1/4 Canchim + 1/4 Nelore.The objective of this study was to evaluate the effects of genetic and non genetic factors on cow weight at calving (CWC of Nellore and 1/2 Canchim + 1/2 Nellore cows, mated to Canchim (5/8 Charolais + 3/8 Zebu and Charolais breed bulls, respectively, and also on the gestation length (GL of their calves, and the weights (W and ages (A at first insemination (FI, conception (FCo, and calving (FC of 1/2 Canchim + 1/2 Nellore heifers. The least squares method was used, with models that included the effects of year and month of calving, age of cow and origin of cow (for the Nellore cows only for the analyses of CWC, breeding season, age of cow, origin of cow and sire of calf (random for the analyses of GL, and year and season of birth and the interaction year x season for the analyses of the traits of the heifers. Year of calving and origin of cow affected CWC. The cows calving from August to November were lighter than the cows calving in December and from May to July. Cow weight linearly increased with age of cow. For the crossbred Canchim x Nellore calves, gestation length was longer for males than for females. The CWC least square means were 450±2 kg (Nellore cows and 502±2 kg (1/2 Canchim + 1/2 Nellore cows and the GL least square means were 291.0±.4 days (1/2 Canchim + 1/2 Nellore calves and 285.7 ± .2 days (1/2 Charolais + 1/4 Canchim + 1/4 Nellore calves. The least square means were 372±2 kg (WFI, 376±2 kg (WFCo, 442±3 kg (WFC, 810±5 days (AFI, 831±6 days (AFCo, and 1116±6 days (AFC for the 1/2 Canchim + 1/2 Nellore heifers. The heritabilities of GL, as a trait of the calf, were equal to .17±.14 (1/2 Canchim + 1/2 Nellore and .69±.31 (1/2 Charolais + 1/4 Canchim + 1/4 Nellore.

  19. Absolute Stereochemistry of 1,2-Diols from Lipids of Thermomicrobia.

    Science.gov (United States)

    Lagutin, Kirill; Wong, Herbert; Vyssotski, Mikhail; MacKenzie, Andrew

    2016-03-01

    1,2-Diol based phospholipids are a well-known feature of bacteria from the class Thermomicrobia. Since these bacteria contain only lipids with an alkyldiol-1-phosphate backbone instead of sn-glycero-3-phosphate, it is important to elucidate the stereochemistry of the 1,2-diols. We have studied the absolute stereochemistry of long-chain 1,2-diols isolated from Thermorudis pharmacophila (formerly known as Thermomicrobia sp. WKT50.2) by nuclear magnetic resonance (NMR) using α-methoxyphenylacetic acid (MPA). Low-temperature (-60 °C) NMR of bis-(R)-MPA ester showed (R) stereochemistry of the 1,2-diols. This is the first report concerning the stereochemistry of natural 1,2-diols, which replace the glyceride moiety in phospholipids. The (R) stereochemistry of the diols is expected as it is the same configuration as for the common bacterial lipid backbone-sn-glycero-3-phosphate. This is the first application of low-temperature NMR of a single MPA derivative for assignment of stereochemistry of natural 1,2-diols. The results were confirmed by the comparison of NMR data with bis-(R)-MPA ester of (R) and rac-1,2-octanediol.

  20. Photoacoustic measurement of differential broadening of the Lambda doublets in NO(X 2Pi 1/2,v = 2-0) by Ar

    Science.gov (United States)

    Pine, A. S.

    1989-01-01

    A differential broadening of the Lambda doublets in the v = 2-0 overtone band of the 2pi1/2 ground electronic state of NO in an Ar buffer gas has been observed by photoacoustic spectroscopy using a tunable color-center laser. The broadening coefficients for the f symmetry components are larger than for the e symmetry components by up to about 6 percent for J of about 16.5. This differential depends on J and vanishes at low J, implicating the anisotropy of the unpaired electron Pi orbital in the plane of rotation. The 2Pi3/2 transitions are slightly broader than the 2Pi1/2 as a result of spin-flipping collisional relaxation. The observed line shapes also exhibit collisional or Dicke narrowing due to velocity-changing collisions.

  1. L1/2 regularization: a thresholding representation theory and a fast solver.

    Science.gov (United States)

    Xu, Zongben; Chang, Xiangyu; Xu, Fengmin; Zhang, Hai

    2012-07-01

    The special importance of L1/2 regularization has been recognized in recent studies on sparse modeling (particularly on compressed sensing). The L1/2 regularization, however, leads to a nonconvex, nonsmooth, and non-Lipschitz optimization problem that is difficult to solve fast and efficiently. In this paper, through developing a threshoding representation theory for L1/2 regularization, we propose an iterative half thresholding algorithm for fast solution of L1/2 regularization, corresponding to the well-known iterative soft thresholding algorithm for L1 regularization, and the iterative hard thresholding algorithm for L0 regularization. We prove the existence of the resolvent of gradient of ||x||1/2(1/2), calculate its analytic expression, and establish an alternative feature theorem on solutions of L1/2 regularization, based on which a thresholding representation of solutions of L1/2 regularization is derived and an optimal regularization parameter setting rule is formulated. The developed theory provides a successful practice of extension of the well- known Moreau's proximity forward-backward splitting theory to the L1/2 regularization case. We verify the convergence of the iterative half thresholding algorithm and provide a series of experiments to assess performance of the algorithm. The experiments show that the half algorithm is effective, efficient, and can be accepted as a fast solver for L1/2 regularization. With the new algorithm, we conduct a phase diagram study to further demonstrate the superiority of L1/2 regularization over L1 regularization.

  2. Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol.

    Science.gov (United States)

    Besheer, Joyce; Fisher, Kristen R; Cannady, Reginald; Grondin, Julie J M; Hodge, Clyde W

    2012-03-17

    Extracellular signal-regulated kinase (ERK(1/2)) has been implicated in modulating drug seeking behavior and is a target of alcohol and other drugs of abuse. Given that the discriminative stimulus (subjective/interoceptive) effects of drugs are determinants of abuse liability and can influence drug seeking behavior, we examined the role of ERK(1/2) in modulating the discriminative stimulus effects of alcohol. Using drug discrimination procedures, rats were trained to discriminate a moderate intragastric (IG) alcohol dose (1g/kg) versus water (IG). Following an alcohol (1g/kg) discrimination session phosphorylated ERK(1/2) (pERK(1/2)) immunoreactivity (IR) was significantly elevated in the amygdala, but not the nucleus accumbens. Therefore, we hypothesized that intra-amygdala inhibition of ERK(1/2) would disrupt expression of the discriminative stimulus effects of alcohol. However, intra-amygdala or accumbens administration of the MEK/ERK(1/2) inhibitor U0126 (1 and 3μg) had no effect on the discriminative stimulus effects of the training dose of alcohol (1g/kg). Contrary to our hypothesis, intra-amygdala infusion of U0126 (3μg) potentiated the discriminative stimulus effects of a low alcohol dose (0.5g/kg) and had no effect following nucleus accumbens infusion. Importantly, site-specific inhibition of pERK(1/2) in each brain region was confirmed. Therefore, the increase in pERK(1/2) IR in the amygdala following systemic alcohol administration may be reflective of the widespread effects of alcohol on the brain (activation/inhibition of brain circuits), whereas the site specific microinjection studies confirmed functional involvement of intra-amygdala ERK(1/2). These findings show that activity of the ERK signaling pathway in the amygdala can influence the discriminative stimulus effects of alcohol.

  3. Identification and Characterization of 1,2-BN Cyclohexene Using Microwave Spectroscopy

    Science.gov (United States)

    Kukolich, Stephen G.; Sun, Ming; Daly, Adam M.; Ishibashi, Jacob S. A.; Liu, Shih-Yuan

    2016-06-01

    1,2-BN Cyclohexene was produced from 1,2-BN Cyclohexane through the loss of H_2 and characterized and identified using a pulsed-beam Fourier-transform microwave spectrometer. The first microwave spectra for 1,2-10BN Cyclohexene 1,2-11BN Cyclohexene have been measured in the frequency range of 5.5-12.5 GHz, providing accurate rotational constants and nitrogen and boron quadrupole coupling strengths for two isotopologues. High-level ab initio calculations provided rotational constants and quadrupole coupling strengths for the precursor 1,2-BN Cyclohexane (C_4H12BN) and 1,2-BN Cyclohexene(C_4H10BN). Calculated molecular properties for 1,2-BN Cyclohexene are in very good agreement with measured parameters. Calculated parameters for the starting material, 1,2-BN Cyclohexane do not agree with the experimental data. Rotational constants for 1,2-11BN Cyclohexene are A = 4702.058(2) MHz, B = 4360.334(1) MHz and C = 2494.407(1) MHz. The inertial defect is Δ_0 = -20.78 amu-Å^2 clearly indicating a nonplanar structure. These microwave experiments show that heating the initial compound, 1,2-BN Cyclohexane, to 60 C in a 1 atm neon stream results in the loss of H_2 and conversion to 1,2-BN Cyclohexene. This appears to be the first characterization of the 1,2-BN Cyclohexene monomer. Supported by the NSF CHE-1057796 and DOE DE-EE-0005658

  4. Homer proteins mediate the interaction between STIM1 and Cav1.2 channels.

    Science.gov (United States)

    Dionisio, Natalia; Smani, Tarik; Woodard, Geoffrey E; Castellano, Antonio; Salido, Gines M; Rosado, Juan A

    2015-05-01

    STIM1 is a ubiquitous Ca2+ sensor of the intracellular, agonist-sensitive, Ca2+ stores that communicates the filling state of the Ca2+ compartments to plasma membrane store-operated Ca2+ (SOC) channels. STIM1 has been presented as a point of convergence between store-operated and voltage-operated Ca2+ influx, both inducing activation of SOC channels while suppressing Cav1.2 channels. Here we report that Homer proteins play a relevant role in the communication between STIM1 and Cav1.2 channels. HEK-293 cells transiently expressing Cav1.2 channel subunits α1, β2 and α2δ-1 exhibited a significant Ca2+ entry upon treatment with a high concentration of KCl. In Cav1.2-expressing cells, treatment with thapsigargin (TG), to induce passive discharge of the intracellular Ca2+ stores, resulted in Ca2+ influx that was significantly greater than in cells not expressing Cav1.2 channels, a difference that was abolished by nifedipine and diltiazem. Treatment with TG induces co-immunoprecipitation of Homer1 with STIM1 and the Cav1.2 α1 subunit. Impairment of Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, or using siRNA Homer1, reduced the association of STIM1 and the Cav1.2 α1 subunit. These findings indicate that Homer is important for the association between both proteins. Finally, treatment with siRNA Homer1 or the PPKKFR peptide enhanced the nifedipine-sensitive component of TG response in Cav1.2-expressing cells. Altogether, these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. An indolocarbazole dimer as a new stereodynamic probe for chiral 1,2-diamines.

    Science.gov (United States)

    Jeon, Hae-Geun; Kim, Min Jun; Jeong, Kyu-Sung

    2014-08-01

    An indolocarbazole dimer that contains aldehyde groups at both ends was prepared by connecting two monomeric units through a rod-like 1,4-butadiynyl spacer. Upon mixing with chiral 1,2-diamines at room temperature, the dimer was in situ converted to the corresponding cyclic diimines in the presence of tetrabutylammonium acetate as a template. The resulting diimines fold to helical conformations of right-handed (P) or left-handed (M) orientations, depending on the absolute stereochemistries of chiral 1,2-diamines. The patterns and intensities of the CD spectra can be used to determine the absolute configurations and enantiomeric excesses of chiral 1,2-diamines.

  6. Spectroscopic and Structural Study of the 1:2 Aluminium(Ⅲ) Complex of Quercetin

    Institute of Scientific and Technical Information of China (English)

    Tian Le LIN; Bao Zhen YAN; Gao Fei HU; Mei WANG

    2006-01-01

    Complex formation between aluminium and quercetin(Q) in methanol was investigated by means of 27 Al solid-state, 13C and 1H NMR and MS(ESI), UV and IR spectra. Formation of the 1:2 complex was favored in methanol relative to all other solvent and the predominant species observed of Al(Ⅲ) has a 1:2 stoichiometry. The fine structure of 1:2 aluminum complex of quercetin was that the aluminum central atom chelated with two quercetin molecules and two methoxyl groups between two five membered rings, its coordination is six, the chelated site was 3-hydroxy-4-carbonyl.

  7. Biodegradation of Used Engine Oil by Acinetobacter junii TBC 1.2

    Directory of Open Access Journals (Sweden)

    Witono Basuki

    2015-11-01

    Full Text Available AbstractThe isolates have capability to degrade used engine oil was obtained from soil in the beach contaminatedwith used engine oil. One of the selected isolates TBC 1.2 was identified by its 16s rDNA as Acinetobacterjunii. The microorganism can use hydrocarbons in used engine oil as the sole carbon source and energy, alsoit significantly degraded almost all hydrocarbon compounds in used engine oil. With its ability Acinetobacterjunii TBC 1.2 has a potency to be utilized for bioremediation of soil polluted with used engine oil.Keywords : biodegradation, used engine oil, Acenitobacter junii TBC 1.2

  8. Facile synthesis of 1',2'-cis-beta-pyranosyladenine nucleosides.

    Science.gov (United States)

    Ando, Takayuki; Shinohara, Hisashi; Luo, Xiong; Kandeel, Mahmoud; Kitade, Yukio

    2007-12-10

    1',2'-cis-beta-Glycosyladenine nucleosides, such as beta-altroside, beta-mannoside, and beta-idoside, were efficiently synthesized from the corresponding 1',2'-trans-beta-6-chloropurine derivatives, beta-glucoside, and beta-galactoside. Nucleophilic substitution of the O-trifluoromethanesulfonyl groups at the C-2' and/or 3' was carried out using tetrabutylammonium acetate or cesium acetate under mild conditions. Subsequent deprotection and amidation afforded the desired compounds, 1',2'-cis-beta-pyranosyladenine nucleosides.

  9. Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

    Directory of Open Access Journals (Sweden)

    Reinhold Zimmer

    2009-09-01

    Full Text Available A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.

  10. Factor analysis of the WISC-R (Spanish version) at 11 age levels between 6 1/2 and 16 1/2 years.

    Science.gov (United States)

    Gass, C S; Demsky, Y I; Martin, P C

    1998-01-01

    The Spanish version of the Wechsler Intelligence Scale for Children-Revised (WISC-R, Wechsler, 1974)-the Escala de Inteligencia para Niños-Revision (EIWN-R, Wechsler, 1982)-has a potentially important role in the assessment of Hispanic children. However, little is known regarding its psychometric characteristics. This study used the normative data from the EIWN-R standardization sample (N = 532 Cuban Americans) to examine its factorial composition and general comparability with the WISC-R. Within each of the 11 age groups (ages 6 1/2 to 16 1/2), the correlation matrix of raw scores was subjected to a principal components analysis and varimax rotation. The results supported a 2-factor solution across age groups roughly corresponding with Wechsler's verbal and performance dimensions. The existence of a meaningful third factor, which has empirical support in the WISC-R literature, failed to emerge for the EIWN-R.

  11. The electrical properties and relaxation behavior of AgNb{sub 1/2}Ta{sub 1/2}O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, K.Ganga, E-mail: kotagirigangaprasad@gmail.com; Niranjan, Manish K.; Asthana, Saket

    2017-02-01

    Polycrystalline AgNb{sub 1/2}Ta{sub 1/2}O{sub 3} powder was prepared by solid state reaction method. Preliminary x-ray diffractogram analysis of some aspects of crystal structure showed that a single phase compound formed exhibiting a monoclinic system. Impedance spectroscopy showed the presence of both bulk and grain boundary effects in the material. The relaxation behavior was studied by fitting electric modulus with Bergman function confirms us the existence of non-Debye type of relaxation the material. The ac conductivity spectrum obeyed Funke's double power law and fitting in results, the hopping parameters n{sub 1},n{sub 2} were indicating the existence of small and large range polaron hopping in the material. The band gap of the material 3.02 eV measured by using UV visible spectroscopy.

  12. Energy storage property in lead free gd doped Na1/2Bi1/2TiO3 ceramics

    Science.gov (United States)

    Zannen, Moneim; Lahmar, Abdelilah; Khemakhem, Hamadi; El Marssi, Mimoun

    2016-11-01

    The Effect of Gadolinium ion incorporation on structure, dielectric and ferroelectric properties of lead-free Na1/2Bi1/2TiO3 (NBT) ceramic was investigated. X-ray diffraction allowed the identification of a pure phase isostructural to NBT. Dielectric measurements showed more pronounced anomalies in the range of depolarization temperature when Gd was added. Antiferroelectric-like behavior with a double pinched hysteresis loop was observed versus temperature in the doped phase. The energy-storage density (W) was calculated using the P-E loops data and was found to vary from 0.45 J cm-3 at room temperature to 0.85 J cm-3 at 413 K, which is promising for energy storage application.

  13. Di-ionizable p-tert-butylcalix[4]arene-1,2-crown-3 ligands in cone and 1,2-alternate conformations: synthesis and metal ion extraction.

    Science.gov (United States)

    Zhang, Dongmei; Cao, Xiaodan; Purkiss, David W; Bartsch, Richard A

    2007-04-21

    Novel di-ionizable p-tert-butylcalix[4]arene-1,2-crown-3 ligands in cone and 1,2-alternate conformations were prepared as potential metal ion extractants. Selective bridging of proximal hydroxyl groups of the calix[4]arene platform by a crown-3 polyether unit was achieved under Mitsunobu reaction conditions. In addition to the carboxylic acid group, the acidity tunable N-(X)sulfonyl oxyacetamide functions [OCH(2)C(O)NHSO(2)X] with X group variation from methyl to phenyl to p-nitrophenyl to trifluomethyl were used as the proton-ionizable groups. Conformations and regioselectivities of the new ligands were established by (1)H and (13)C NMR spectroscopy. Competitive solvent extractions of alkali metal cations and of alkaline earth metal cations from aqueous solutions into chloroform were performed, as were single species extractions of lead(ii) and mercury(ii).

  14. Electrical properties of Ba(Dy{sub 1/2}Nb{sub 1/2})O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Nath, K. Amar, E-mail: karn190@gmail.com [University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Chandra, K. P., E-mail: kpchandra23@gmail.com [Department of Physics, S.M. College, Bhagalpur 812001 (India); Dubey, K., E-mail: kirandubey45@yahoo.com [Department of Physics, G.S. College for Women 831001 (India); Prasad, K., E-mail: k.prasad65@gmail.com [University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Aryabhatta Centre for Nanoscience and Nanotechnology, Aryabhatta Knowledge University, Patna, 800001 (India)

    2016-05-06

    Polycrystalline Ba(Dy{sub 1/2}Nb{sub 1/2})O{sub 3} was prepared using a high-temperature solid-state reaction method. X-ray diffraction analysis indicated the formation of a single-phase cubic structure having space group Pm3m. AC impedance plots as a function of frequency at different temperatures were used to analyse the electrical behaviour of the sample, which indicated the negative temperature coefficient of resistance character. Complex impedance analysis targeted non-Debye type dielectric relaxation. Frequency dependent ac conductivity data obeyed Jonscher’s power law. The apparent activation energy was estimated to be 0.97 eV at 1 kHz.

  15. 1,2-二酮类化合物的合成研究进展%The Synthesis Development of 1,2-Diketone

    Institute of Scientific and Technical Information of China (English)

    庄丹闻; 崔冬梅

    2010-01-01

    1,2-二酮类化合物作为重要的有机合成中间体被广泛应用在高分子材料、农药、医药、化工原料等领域,在医药领域的应用主要是合成一些咪唑环、喹诺西林类的药物.也可以用于合成一些聚合物.本文概述了通过不同的原料,采用氧化、重排、亲核取代的方法得到1,2-二酮类化合物.

  16. Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells.

    Science.gov (United States)

    Garamvölgyi, Rita; Dobos, Judit; Sipos, Anna; Boros, Sándor; Illyés, Eszter; Baska, Ferenc; Kékesi, László; Szabadkai, István; Szántai-Kis, Csaba; Kéri, György; Őrfi, László

    2016-01-27

    Melanoma is an aggressive form of skin cancer and it is generally associated with poor prognosis in patients with late-stage disease. Due to the increasing occurrence of melanoma, there is a need for the development of novel therapies. A new series of diarylamide and diarylurea derivatives containing imidazo[1,2-a]pyridine or imidazo[1,2-a]pyrazine scaffold was designed and synthesized to investigate their in vitro efficacy against the A375P human melanoma cell line. We found several compounds expressing submicromolar IC50 values against the A375P cells, from which 15d, 17e, 18c, 18h, 18i demonstrated the highest potencies with IC50 below 0.06 μM.

  17. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.

    Science.gov (United States)

    Choi, Jae Sue; Kim, Ji-Hye; Ali, Md Yousof; Jung, Hee Jin; Min, Byung-Sun; Choi, Ran Joo; Kim, Gun-Do; Jung, Hyun Ah

    2015-12-01

    It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-γ (PPAR-γ) and CCAAT/enhancer binding protein-α (C/EBP-α). However, the signaling-based mechanism of the inhibitory role of epiberberine in the early stages of 3T3-L1 adipocyte differentiation is uncharacterized. Here, we show that epiberberine had inhibitory effects on adipocyte differentiation and significantly decreased lipid accumulation by downregulating an adipocyte-specific transcription factor, sterol regulatory element-binding protein-1 (SREBP-1). Furthermore, we observed that epiberberine markedly suppressed the differentiation-mediated phosphorylation of components of both the Raf/mitogen-activated protein kinase 1 (MEK1)/extracellular signal-regulated protein kinase 1/2 (ERK1/2) and AMP-activated protein kinase-α1 (AMPKα)/Akt pathways. In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. These results indicate that the anti-adipogenic mechanism of epiberberine is associated with inhibition of phosphorylation of Raf/MEK1/ERK1/2 and AMPKα/Akt, followed by downregulation of the major transcription factors of adipogenesis, such as PPAR-γ, C/EBP-α, and SREBP-1, and FAS. Taken together, this study suggests that the anti-adipogenic effect of epiberberine is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. Moreover, the anti-adipogenic effects of epiberberine were not accompanied by modulation of β-catenin.

  18. Electronic structure, magnetic and electrical properties of multiferroic PbFe{sub 1/2}Ta{sub 1/2}O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Bharti, Chandrahas, E-mail: bharti_chandrahas@yahoo.com [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Dutta, Alo [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Shannigrahi, Santiranjan [Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602 (Singapore); Sinha, T.P. [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India)

    2012-03-15

    Structural analysis of the synthesized lead iron tantalate, PbFe{sub 1/2}Ta{sub 1/2}O{sub 3} (PFT) is performed by the refinement of the X-ray diffraction data at room temperature using the GSAS code. Energy dispersive X-ray spectrometry analysis is done to find out the chemical composition. The electronic structure of PFT is calculated by the first principles full potential linearized augmented plane wave method. The spin polarized density of states shows the insulating nature. The magnetic moment of 4.3 {mu}B per Fe ion is obtained from the electronic structure calculation using the GGA+U method and compared with the available experimental data. The electronic structure of the PFT is verified by X-ray photoemission spectroscopy. The dielectric spectroscopy is applied to investigate the electrical properties of PFT in the frequency range from 100 Hz to 1 MHz and in the temperature range from 183 to 253 K. The frequency dependent electrical data are analyzed by conductivity formalism. The relaxation mechanism is explained using the Cole-Cole approach. - Highlights: Black-Right-Pointing-Pointer Rietveld refinement of PbFe{sub 1/2}Ta{sub 1/2}O{sub 3} (PFT) is performed using the GSAS code. Black-Right-Pointing-Pointer The electronic structure of PFT is calculated by the first principles. Black-Right-Pointing-Pointer The spin polarized density of states show the insulating nature of PFT. Black-Right-Pointing-Pointer The magnetic moment of PFT is 4.3 {mu}B per Fe ion.

  19. The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover.

    Science.gov (United States)

    Luo, Guangzuo; Gruhler, Albrecht; Liu, Ying; Jensen, Ole N; Dickson, Robert C

    2008-04-18

    Eisosomes are recently described fungal structures that play roles in the organization of the plasma membrane and endocytosis. Their major protein components are Pil1 and Lsp1, and previous studies showed that these proteins are phosphorylated by the sphingolipid long-chain base-activated Pkh1 and Pkh2 protein kinases in vitro. We show that Pkh1 and Pkh2 phosphorylate Pil1 and Lsp1 in vivo to produce species B, and that heat stress, which activates Pkh1 and Pkh2, generates a more highly phosphorylated species, C. Cells with low Pkh activity lack species B and C and contain abnormally organized eisosomes. To verify that Pil1 phosphorylation is essential for correct eisosome organization, phosphorylated serine and threonine residues were identified and changed to alanines. A variant Pil1 protein lacking five phosphorylation sites did not form eisosomes during log phase growth, indicating that phosphorylation is critical for eisosome organization. We also found that eisosomes are dynamic structures and disassemble when the Ypk protein kinases, which are activated by the sphingolipid-Pkh signaling pathway, are inactivated or when the sphingolipid signal is pharmacologically blocked with myriocin. We conclude that eisosome formation and turnover are regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway. These data and previous data showing that endocytosis is regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway suggest that Pkh1 and -2 respond to changes in membrane sphingolipids and transmit this information to eisosomes via Pil1 phosphorylation. Eisosomes then control endocytosis to align the composition and function of the plasma membrane to match demand.

  20. Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of dicloromezotiaz as a lepidoptera insecticide acting on nicotinic acetylcholine receptors(1,2).

    Science.gov (United States)

    Zhang, Wenming; Holyoke, Caleb W; Barry, James; Cordova, Daniel; Leighty, Robert M; Tong, My-Hanh T; Hughes, Kenneth A; Lahm, George P; Pahutski, Thomas F; Xu, Ming; Briddell, Twyla A; McCann, Stephen F; Henry, Yewande T; Chen, Yuzhong

    2017-02-15

    A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identification of dicloromezotiaz as a potent insecticide to control a broad range of lepidoptera. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.

  1. The influence of oxygen on the surface chemistry of 1,2-propanediol on Pd(111)

    Science.gov (United States)

    Williams, Rhea M.; Medlin, J. Will

    2014-01-01

    The surface chemistry of 1,2-propanediol (PDO) has been studied on oxygen precovered Pd(111) using temperature programmed desorption (TPD) and high-resolution electron energy loss spectroscopy (HREELS). Adsorbed 1,2-propanedioxy (-OCH(CH3)CH2O-) forms from the activation of the O-H bonds. When the concentration of O(a) is large compared to 1,2-propanedioxy, no H2 is produced and the dialkoxide reacts to form H2O, CO through decarbonylation, and CO2 through decarboxylation. Unreacted oxygen also desorbs as O2 at high temperature. Conversely, when the concentration of O(a) is small relative to 1,2-propanedioxy, the dialkoxide reacts to form decomposition products (H2, CO), oxidation products (H2O, glyoxal, methylglyoxal, formaldehyde) and deoxygenation products (ethylene, propylene). Co-adsorbed oxygen increases the overall coverage of PDO that can undergo decomposition, which in turn strongly influences decomposition activation barriers and products.

  2. Enantioselective Synthesis of Terminal 1,2-Diols from Acyl Chlorides

    Institute of Scientific and Technical Information of China (English)

    邵攀霖; 申理滔; 叶松

    2012-01-01

    Optically active terminal 1,2-diols were prepared with high enantiopurity via the TMS-quinidine-catalyzed en- antioselective cyclization of acyl chlorides and oxaziridine, followed by reductive ring-opening of the cycloadducts.

  3. Neel order in the two-dimensional S=1/2 Heisenberg Model

    OpenAIRE

    Löw, Ute

    2007-01-01

    The existence of Neel order in the S=1/2 Heisenberg model on the square lattice at T=0 is shown using inequalities set up by Kennedy, Lieb and Shastry in combination with high precision Quantum Monte Carlo data.

  4. New Salmonella serotype: Salmonella enteritidis serotype Grandhaven (30(1):r:1,2).

    OpenAIRE

    McDougal, D L; Treleaven, B E; Renshaw, E C

    1982-01-01

    A new Salmonella serotype, Salmonella enteritidis serotype Grandhaven (30(1):r:1,2), was isolated from the stool of a 35-year-old man with mild gastroenteritis. He had just returned from Sudan, Africa.

  5. Batch gradient method with smoothing L1/2 regularization for training of feedforward neural networks.

    Science.gov (United States)

    Wu, Wei; Fan, Qinwei; Zurada, Jacek M; Wang, Jian; Yang, Dakun; Liu, Yan

    2014-02-01

    The aim of this paper is to develop a novel method to prune feedforward neural networks by introducing an L1/2 regularization term into the error function. This procedure forces weights to become smaller during the training and can eventually removed after the training. The usual L1/2 regularization term involves absolute values and is not differentiable at the origin, which typically causes oscillation of the gradient of the error function during the training. A key point of this paper is to modify the usual L1/2 regularization term by smoothing it at the origin. This approach offers the following three advantages: First, it removes the oscillation of the gradient value. Secondly, it gives better pruning, namely the final weights to be removed are smaller than those produced through the usual L1/2 regularization. Thirdly, it makes it possible to prove the convergence of the training. Supporting numerical examples are also provided.

  6. USGS 1:12000 (Quarter 7 1/2 Minute) Quadrangle Index

    Data.gov (United States)

    Minnesota Department of Natural Resources — This is a mathematically generated grid in which each polygon represents one quarter of a standard USGS 7 1/2 minute quadrangle. The result is a 3 3/4 minute...

  7. Microwave Spectrum and Molecular Structure of the ARGON-CIS-1,2-DICHLOROETHYLENE Complex

    Science.gov (United States)

    Marshall, Mark D.; Leung, Helen O.; Nelson, Craig J.; Yoon, Leonard H.

    2016-06-01

    The non-planar molecular structure of the complex formed between the argon atom and cis-1,2-dichloroethylene is determined via analysis of its microwave spectrum. Spectra of the 35Cl and 37Cl isotopologues are observed in natural abundance and the nuclear quadrupole splitting due to the two chlorine nuclei is fully resolved. In addition, the complete quadrupole coupling tensor for the cis-1,2-dichloroethylene molecule, including the single non-zero off-diagonal element, has been determined. Unlike the argon-cis-1,2-difluoroethylene and the argon-vinyl chloride complexes, tunneling between the two equivalent non-planar configurations of argon-cis-1,2-dichloroethylene is not observed.

  8. One-pot Synthesis of 4-Trifluoromethyl-1,2-dihydropyrimidines

    Institute of Scientific and Technical Information of China (English)

    LIN,Yun; LIU,Jin-Tao; YANG,Xian-Ji

    2007-01-01

    4-Trifluoromethyl-1,2-dihydropyrimidines were synthesized in moderate yields by the one-pot reaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one, aldehydes and ammonia catalyzed by zinc chloride under mild conditions.

  9. SYNTHESIS OF 1,2-ACEANTHRYLENEDIONE THROUGH ACYLATION OF ANTHRACENE WITH OXALYL CHLORIDE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Acylation of anthracene and oxalyl chloride in the presence of anhydrous AlCl3 was investigated. Pure 1,2-aceanthrylenedione, which is used as new functional macromolecule, was prepared by extraction and recrystallation. The structure of 1,2-aceanthrylenedione was identified by measure of melting point, GC/MS, FTIR and 1HNMR analyses. The influences of various parameters, such as solvent, dosage of catalyst, molar ratio of anthracene to oxalyl chloride, reaction temperature, and reaction time were studied. The anhydrous AlCl3 was found to catalyze the reaction with high yeild and good selectivity. When the reaction temperature is 303K, reaction time is 5h and molar ratio of anthracene to oxalyl chloride is 1:2, the yield and selectivity of 1,2-aceanthrylenedione is 83.8 % and 92.3% respectively.

  10. SYNTHESIS OF 1,2-ACEANTHRYLENEDIONE THROUGH ACYLATION OF ANTHRACENE WITH OXALYL CHLORIDE

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chunyan; CHEN Min; YU Long; JIANG Deli YAN Yongsheng

    2007-01-01

    Acylation of anthracene and oxalyl chloride in the presence of anhydrous AlCl3 was investigated. Pure 1,2-aceanthrylenedione, which is used as new functional macromolecule, was prepared by extraction and recrystallation. The structure of 1,2-aceanthrylenedione was identified by measure of melting point, GC/MS, FTIR and 1HNMR analyses. The influences of various parameters,such as solvent, dosage of catalyst, molar ratio of anthracene to oxalyl chloride, reaction temperature, and reaction time were studied. The anhydrous AlCl3 was found to catalyze the reaction with high yeild and good selectivity. When the reaction temperature is 303K, reaction time is 5h and molar ratio of anthracene to oxalyl chloride is 1:2, the yield and selectivity of 1,2-aceanthrylenedione is 83.8 % and 92.3% respectively.

  11. Depolarization temperature and piezoelectric properties of Na1/2Bi1/2TiO3–Na1/2Bi1/2(Zn1/3Nb2/3)O3 ceramics by two-stage calcination method

    Indian Academy of Sciences (India)

    Xin-Yu Liu; Chang-Rong Zhou; Zhao-Hui Shan

    2007-12-01

    A new group of NBT-based lead-free piezoelectric ceramics, Na1/2Bi1/2TiO3–Na1/2Bi1/2(Zn1/3Nb2/3)O3, was synthesized using the two-stage calcination method and depolarization temperatures and piezoelectric properties were also investigated. The XRD analysis showed that the ceramics system had a morphotropic phase boundary (MPB) between the rhombohedral and the tetragonal structure. The highest piezoelectric properties of 33 = 97 pC/N and = 0.46 were obtained near MPB compositions. Furthermore, the depolarization temperatures near MPB compositions were slightly decreased and the lowest d was maintained at 210°C.

  12. The Nature of Acid-Catalyzed Acetalization Reaction of 1,2-Propylene Glycol and Acetaldehyde

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Chen; Chen, Hui; Li, Xia; Hu, Jianli; Liang, Baochen [Tianjin University of Technology, Tianjin (China)

    2015-08-15

    We investigated catalytic activity of ion-exchange resins in acetalization of 1,2-propylene glycol with acetaldehyde. The impacts of reaction variables, such as temperature, reaction time, catalyst loading and feedstock composition, on the conversion of 1,2-propylene glycol were measured. The life of the catalyst was also studied. Furthermore, the reaction kinetics of 1,2-propylene glycol acetalization was studied. It was found that reaction rate followed the first order kinetics to acetaldehyde and 1,2-propylene glycol, respectively. Therefore, overall acetalization reaction should follow the second-order reaction kinetics, expressed as r - kC{sup nA}{sub A}C{sup nB}{sub B} = 19.74e{sup -650/T}C{sup 1}{sub A}C{sup 1}{sub B}.

  13. The anomalous dimension of spin-1/2 baryons in many flavors QCD

    CERN Document Server

    Vecchi, Luca

    2016-01-01

    We derive the anomalous dimension of spin-1/2 baryon operators in QCD at leading 1/Nf order. Within this approximation the complication resulting from the mixing with an infinite number of evanescent operators can be easily bypassed.

  14. USGS 1:24000 (7 1/2 Minute) Quadrangle Index

    Data.gov (United States)

    Minnesota Department of Natural Resources — Mathematically generated grid representing USGS 7 1/2 Minute Quadrangle Map outlines. Quadrangle names and standard identifiers are included with the data set.

  15. Synthesis optimisation and characterisation of the organic-inorganic layered materials ZnS(m-xylylenediamine)1/2 and ZnS(p-xylylenediamine)1/2

    Science.gov (United States)

    Luberda-Durnaś, K.; Guillén, A. González; Łasocha, W.

    2016-06-01

    Hybrid organic-inorganic layered materials of the type ZnS(amine)1/2, where amine=m-xylylenediamine (MXDA) or p-xylylenediamine (PXDA), were synthesised using a simple solvothermal method. Since the samples crystallised in the form of very fine powder, X-ray powder diffraction techniques were used for structural characterisation. The crystal structure studies, involving direct methods, show that both compounds crystallised in the orthorhombic crystal system, but in different space groups: ZnS(MXDA)1/2 in non-centrosymmetric Ccm21, ZnS(PXDA)1/2 in centrosymmetric Pcab. The obtained materials are built according to similar orders: semiconducting monolayers with the formula ZnS, parallel to the (010) plane, are separated by diamines. The organic and inorganic fragments are connected by covalent bonds between metal atoms of the layers and nitrogen atoms of the amino groups. The optical properties of the hybrid materials differ from those of their bulk counterpart. In both compounds a blue-shift of about 0.8 or 0.9 eV was observed with reference to the bulk phase of ZnS.

  16. Absorption spectrum, mass spectrometric properties, and electronic structure of 1,2-benzoquinone.

    Science.gov (United States)

    Albarran, Guadalupe; Boggess, William; Rassolov, Vitaly; Schuler, Robert H

    2010-07-22

    Absorption spectrophotometric and mass spectrometric properties of 1,2-benzoquinone, prepared in aqueous solution by the hexachloroiridate(IV) oxidation of catechol and isolated by HPLC, are reported. Its absorption spectrum has a broad moderately intense band in the near UV with an extinction coefficient of 1370 M(-1)cm(-1) at its 389 nm maximum. The oscillator strength of this band contrasts with those of the order-of-magnitude stronger approximately 250 nm bands of most 1,4-benzoquinones. Gaussian analysis of its absorption spectrum indicates that it also has modestly intense higher energy bands in the 250-320 nm region. In atmospheric pressure mass spectrometric studies 1,2-benzoquinone exhibits very strong positive and negative mass 109 signals that result from the addition of protons and hydride ions in APCI and ESI ion sources. It is suggested that the hydride adduct is formed as the result of the highly polar character of ortho-quinone. On energetic collision the hydride adduct loses an H atom to produce the 1,2-benzosemiquinone radical anion. The present studies also show that atmospheric pressure mass spectral patterns observed for catechol are dominated by signals of 1,2-benzoquinone resulting from oxidation of catechol in the ion sources. Computational studies of the electronic structures of 1,2-benzoquinone, its proton and hydride ion adducts, and 1,2-benzosemiquinone radical anion are reported. These computational studies show that the structures of the proton and hydride adducts are similar and indicate that the hydride adduct is the proton adduct of a doubly negatively charged 1,2-benzoquinone. The contrast between the properties of 1,2- and 1,4-benzoquinone provides the basis for considerations on the effects of conjugation in aromatic systems.

  17. Synthesis and Some Reactions of 3-Chloro-2-(cyanomethylene-1,2-dihydroquinoxalines

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfleiderer

    2004-03-01

    Full Text Available 2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene- 1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene-1,2- dihydroquinoxaline (2e with pyridine and its methyl derivatives led to the zwitterionic structures 6a-6c. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses.

  18. Platinum Catalyzed Ring-Opening of 1,2-Cyclopropanated Sugars with O-Nucleophiles

    DEFF Research Database (Denmark)

    Beyer, Jürgen; Skaanderup, Philip Robert; Madsen, Robert

    1999-01-01

    In the presence of a catalytic amount of Zeise's dimer 1,2-cyclopropanated sugars undergo regioselective ring-opening at C-1 with O-nucleophiles including alcohols, phenols and water to produce 2-C-branched carbohydrates.......In the presence of a catalytic amount of Zeise's dimer 1,2-cyclopropanated sugars undergo regioselective ring-opening at C-1 with O-nucleophiles including alcohols, phenols and water to produce 2-C-branched carbohydrates....

  19. Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

    Directory of Open Access Journals (Sweden)

    Héctor M Mora-Montes

    2010-02-01

    Full Text Available Alpha 1,2-mannosidases from glycosyl hydrolase family 47 participate in N-glycan biosynthesis. In filamentous fungi and mammalian cells, α1,2-mannosidases are present in the endoplasmic reticulum (ER and Golgi complex and are required to generate complex N-glycans. However, lower eukaryotes such Saccharomyces cerevisiae contain only one α1,2-mannosidase in the lumen of the ER and synthesise high-mannose N-glycans. Little is known about the N-glycan structure and the enzyme machinery involved in the synthesis of these oligosaccharides in the dimorphic fungus Sporothrix schenckii. Here, a membrane-bound α-mannosidase from S. schenckii was solubilised using a high-temperature procedure and purified by conventional methods of protein isolation. Analytical zymograms revealed a polypeptide of 75 kDa to be responsible for enzyme activity and this purified protein was recognised by anti-α1,2-mannosidase antibodies. The enzyme hydrolysed Man9GlcNAc2 into Man8GlcNAc2 isomer B and was inhibited preferentially by 1-deoxymannojirimycin. This α1,2-mannosidase was localised in the ER, with the catalytic domain within the lumen of this compartment. These properties are consistent with an ER-localised α1,2-mannosidase of glycosyl hydrolase family 47. Our results also suggested that in contrast to other filamentous fungi, S. schenckii lacks Golgi α1,2-mannosidases and therefore, the processing of N-glycans by α1,2-mannosidases is similar to that present in lower eukaryotes.

  20. Enhancing Natural Attenuation through Bioaugmentation with Aerobic Bacteria that Degrade cis-1,2-Dichloroethene

    Science.gov (United States)

    2010-05-01

    cDCE cis-1,2-dichloroethene cfu colony forming units CMO cyclohexanone monooxygenase DCA 1,2-dichloroethane DNA deoxyribonucleic acid...of JS666) and (2) cyclohexanone monooxygenase (CMO) (based on the cyclohexanone monooxygenase gene of JS666). Additionally, a putative universal (UNI...molecular probes (one based on the isocitrate lyase gene and one based on the cyclohexanone monooygenase gene). In addition, JS666 activity and

  1. Dielectric, piezoelectric, and ferroelectric properties of MnCO3-added 74(Bi(1/2)Na(1/2)) TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2BaTiO3 lead-free piezoelectric ceramics.

    Science.gov (United States)

    Hu, Hanchen; Zhu, Mankang; Hou, Yudong; Yan, Hui

    2009-05-01

    74(Bi(1/2)Na(1/2))TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2BaTiO3-x MnCO3 lead-free piezoelectric ceramics were synthesized by conventional solid oxide routine. The tetragonal 74(Bi(1/2)Na(1/2))TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2 BaTiO3 (BNKB) exhibits high depolarization temperature T(d) of 195 degrees C; however, its properties are far from satisfactory for practical application and need to be improved. The experiments show that the addition of MnCO3 reduces the tetragonality c/a and increases the cell volume. In addition, it revealed that the suitable addition of MnCO3 promotes the sintering and increases the densities of BNKB ceramics. The addition of MnCO3 also enhances the relaxor behavior of BNKB ceramics due to the reconstruct of the disorder arrays. Due to the effect of the crystal lattice, grain growth, and relaxor behavior, the optimal electric properties were realized at MnCO3 addition x of 0.16: the dielectric permittivity epsilon(r) = 1047, dielectric dissipation tandelta = 0.022, piezoelectric strain d33 = 140 pC/N, mechanical coupling k(p) = 0.18, mechanical quality Q(m) = 89 while the depolarization temperature T(d) stays relatively high at 175 degrees C. The effect and mechanism of Mn doping on the electrical properties were discussed in detail.

  2. Remarks on mass and angular momenta for $U(1)^2$-invariant initial data

    CERN Document Server

    Alaee, Aghil

    2015-01-01

    We extend Brill's positive mass theorem to a large class of asymptotically flat, maximal, $U(1)^2$-invariant initial data sets on simply connected four dimensional manifolds $\\Sigma$. Moreover, we extend the local mass angular momenta inequality result Ref [1] for $U(1)^2$ invariant black holes to the case with nonzero stress energy tensor with positive matter density and energy-momentum current invariant under the above symmetries.

  3. su(1,2) Algebraic Structure of XYZ Antiferromagnetic Model in Linear Spin-Wave Frame

    Institute of Scientific and Technical Information of China (English)

    GUAN Yong; JIN Shuo; LIN Bing-Sheng; XIE Bing-Hao; JING Si-Cong; YU Zhao-Xian; HOU Jing-Min

    2008-01-01

    The XYZ antiferromagnetic model in linear spin-wave frame is shown explicitly to have an su(1,2) aigebraic structure: the Hamiltonian can be written as a linear function of the su(1,2) algebra generators. Based on it, the energy eigenvalues are obtained by making use of the similar transformations, and the algebraic diagonalization method is investigated. Some numerical solutions are given, and the results indicate that only one group solution could be accepted in physics.

  4. Solution phase isomerization of vibrationally excited singlet nitrenes to vibrationally excited 1,2-didehydroazepine.

    Science.gov (United States)

    Burdzinski, Gotard T; Middleton, Chris T; Gustafson, Terry L; Platz, Matthew S

    2006-11-22

    Photolysis of phenyl and o-biphenylyl azide (at 270 nm) releases vibrationally excited singlet nitrene which isomerizes to the corresponding hot 1,2-didehydroazepine at a rate competitive with thermal relaxation. Using ultrafast vibrational spectroscopy we observe the formation of vibrationally excited 1,2-4,6-azacycloheptatetraene (1,2-didehydroazepine) in picoseconds following photolysis of phenyl azide in chloroform and o-biphenylyl azide in acetonitrile at ambient temperature.

  5. The Pseudorabies Virus VP1/2 Tegument Protein Is Required for Intracellular Capsid Transport†

    OpenAIRE

    Luxton, G.W. Gant; Lee, Joy I-Hsuan; Haverlock-Moyns, Sarah; Schober, Joseph Martin; Smith, Gregory Allan

    2006-01-01

    Transport of capsids in cells is critical to alphaherpesvirus infection and pathogenesis; however, viral factors required for transport have yet to be identified. Here we provide a detailed examination of capsid dynamics during the egress phase of infection in Vero cells infected with pseudorabies virus. We demonstrate that the VP1/2 tegument protein is required for processive microtubule-based transport of capsids in the cytoplasm. A second tegument protein that binds to VP1/2, UL37, was nec...

  6. WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.

    Science.gov (United States)

    Zhou, Bo; Wang, Dexuan; Feng, Xiuyan; Zhang, Yiqian; Wang, Yanhui; Zhuang, Jieqiu; Zhang, Xuemei; Chen, Guangping; Delpire, Eric; Gu, Dingying; Cai, Hui

    2012-03-01

    WNK [with no lysine (K)] kinase is a subfamily of serine/threonine kinases. Mutations in two members of this family (WNK1 and WNK4) cause pseudohypoaldosteronism type II featuring hypertension, hyperkalemia, and metabolic acidosis. WNK1 and WNK4 were shown to regulate sodium chloride cotransporter (NCC) activity through phosphorylating SPAK and OSR1. Previous studies including ours have also shown that WNK4 inhibits NCC function and its protein expression. A recent study reported that a phorbol ester inhibits NCC function via activation of extracellular signal-regulated kinase (ERK) 1/2 kinase. In the current study, we investigated whether WNK4 affects NCC via the MAPK ERK1/2 signaling pathway. We found that WNK4 increased ERK1/2 phosphorylation in a dose-dependent manner in mouse distal convoluted tubule (mDCT) cells, whereas WNK4 mutants with the PHA II mutations (E562K and R1185C) lost the ability to increase the ERK1/2 phosphorylation. Hypertonicity significantly increased ERK1/2 phosphorylation in mDCT cells. Knock-down of WNK4 expression by siRNA resulted in a decrease of ERK1/2 phosphorylation. We further showed that WNK4 knock-down significantly increases the cell surface and total NCC protein expressions and ERK1/2 knock-down also significantly increases cell surface and total NCC expression. These data suggest that WNK4 inhibits NCC through activating the MAPK ERK1/2 signaling pathway.

  7. 9,10-Dioxa-1,2-diaza-anthracene derivatives from tetrafluoropyridazine

    Directory of Open Access Journals (Sweden)

    Graham Pattison

    2010-05-01

    Full Text Available Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the synthesis of unusual polyfunctional heterocyclic architectures. The tricyclic scaffold reacts with amines and sodium ethoxide providing a short series of functional 9,10-dioxa-1,2-diaza-anthracene systems.

  8. NQR Study of the Structural Phase Transition in 1,2-Diphenylhydrazine

    Science.gov (United States)

    Matsuura, Hazime; Matsuzaki, Tomio; Fukazawa, Yuji; Abe, Yoshihito

    1982-12-01

    14N NQR lines in 1,2-diphenylhydrazine have been investigated between 4.2 K and 370 K by using a pulsed spectrometer. With increasing temperature, the number of resonance line in NQR spectra decreased from six lines to three lines above 115 K. The temperature dependence of resonance lines reveals that 1,2-diphenylhydrazine makes a second order structural phase transition around 115 K. An information about the molecular structure is also obtained.

  9. Understanding the Role of TSC1/2 in Cerebellar Purkinje Neurons

    Science.gov (United States)

    2016-09-01

    AWARD NUMBER: W81XWH-15-1-0189 TITLE: Understanding the role of TSC1/2 in cerebellar Purkinje neurons PRINCIPAL INVESTIGATOR: Mustafa Sahin...5a. CONTRACT NUMBER Understanding the role of TSC1/2 in cerebellar Purkinje neurons 5b. GRANT NUMBER W81XWH-15-1-0189 5c. PROGRAM ELEMENT...Purkinje cells are the sole output neuron of the cerebellum, and previously we have shown that Tsc1 mutant Purkinje cells cause autistic-like

  10. Adsorption structure, thermal reaction and initial pathways of 1,2-benzyne on Cu(100)

    Science.gov (United States)

    Lin, Jong-Liang; Lin, Yi-Shiue; Lin, Bo-Chiuan; Liao, Yuan-Hsuan; Chen, Yi-Ting; Chen, Shang-Wei; Jhuang, Jyun-Yi; Lee, Yarong; Lin, Jiing-Chyuan

    2016-10-01

    1,2-C6H4I2 is used as precursor to generate 1,2-C6H4 (ortho-C6H4) on Cu(100). The reflection-absorption infrared spectroscopy (RAIRS) confirms the vertical adsorption geometry of 1,2-C6H4 on Cu(100), which agrees with that predicted theoretically. H2 evolving between 620 K and 870 K is the only reaction product detected from the 1,2-C6H4 decomposition in temperature-programmed reaction/desorption (TPR/D). Our calculations indicate that the 1,2-C6H4 primarily undergoes C3-H bond scission, forming 1,2,3-C6H3, with distorted C6 ring, and H atom on the surface without ring rupture (C1-C2 bond dissociation) prior to H loss. Furthermore, isomerization of the 1,2-C6H4, if it does occur, may proceed via dehydrogenation-hydrogenation, instead of H-shift.

  11. Microbial formation, biotechnological production and applications of 1,2-propanediol

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, G.N. [Dept. of Biochemistry and Cell Biology, Rice Univ., Houston, TX (United States); San, K.Y. [Dept. of Bioengineering, Rice Univ., TX (United States)

    2001-07-01

    This short review covers metabolic pathways, genetics and metabolic engineering of 1,2-propanediol formation in microbes. 1,2-Propanediol production by bacteria and yeasts has been known for many years and two general pathways are recognized. One involves the metabolism of deoxyhexoses, where lactaldehyde is formed during the glycolytic reactions and is then reduced to 1,2-propanediol. The second pathway derives from the formation of methylglyoxal from dihydroxyacetonephosphate and its subsequent reduction to 1,2-propanediol. The enzymes involved in the reduction of methylglyoxal can generate isomers of lactaldehyde or acetol, which can be further reduced by specific reductases, giving chiral 1,2-propanediol as the product. The stereospecificity of the enzymes catalyzing the two reduction steps is important in deriving a complete pathway. Through genetic engineering, appropriate combinations of enzymes have been brought together in Escherichia coli and yeast to generate 1,2-propanediol from glucose. The optimization of these strains may yield microbial processes for the production of this widely used chemical. (orig.)

  12. ERα and ERK1/2 MAP kinase expression in microdissected stromal and epithelial endometrial cells

    Directory of Open Access Journals (Sweden)

    Said Abu Alkhair Mohamed

    2014-03-01

    Total and phosphorylated levels for ERK1/2 and ERα were measured by quantitation of signals from Western blots using specific antibodies against the active and total forms of ERK1/2 and against ERα. When the level of the proteins was quantitated and normalized to β actin from microdissected stroma and epithelium, no significant difference was detected in the levels of these proteins between the two tissue compartments. There was a trend toward higher expression in the stroma vs. epithelium, respectively (active ERK1/2 0.45 ± 0.17 vs. 0.2 ± 0.65; total ERK1/2 0.54 ± 0.35 vs. 0.28 ± 0.23; ERα 0.82 ± 0.28 vs. 0.54 ± 0.18; n = 6. These data demonstrate that there are comparable levels of ERα (P = 0.41, total ERK1/2 (P = 0.18 and active ERK1/2 (P = 0.13 in the stroma and epithelium of proliferative phase endometrium with a trend toward higher expression of these proteins in the stromal compartment.

  13. Ovarian Cancer and BRCA1/2 Testing: Opportunities to improve clinical care and disease prevention

    Directory of Open Access Journals (Sweden)

    Katherine eKarakasis

    2016-05-01

    Full Text Available Without prevention or screening options available, ovarian cancer is the most lethal malignancy of the female reproductive tract. High grade serous ovarian cancer (HGSOC is the most common histologic subtype, and the role of germline BRCA1/2 mutation in predisposition and prognosis is established. Given the targeted treatment opportunities with PARP inhibitors, a predictive role for BRCA1/2 mutation has emerged. Despite recommendations to provide BRCA1/2 testing to all women with histologically confirmed HGSOC, uniform implementation remains challenging. The opportunity to review and revise genetic screening and testing practices will identify opportunities where universal adoption of BRCA1/2 mutation testing will impact and improve treatment of women with ovarian cancer. Improving education and awareness of genetic testing for women with cancer, as well as the broader general community, will help focus much needed attention on opportunities to advance prevention and screening programs in ovarian cancer. This is imperative not only for women with cancer, those at risk of developing cancer, but also for their first-degree relatives. In addition, BRCA1/2 testing may have direct implications for patients with other types of cancers, many which are now being found to have BRCA1/2 involvement.

  14. Kinetics of heavy metal inhibition of 1,2-dichloroethane biodegradation in co-contaminated water.

    Science.gov (United States)

    Arjoon, Ashmita; Olaniran, Ademola Olufolahan; Pillay, Balakrishna

    2015-03-01

    Sites co-contaminated with heavy metals and 1,2-DCA may pose a greater challenge for bioremediation, as the heavy metals could inhibit the activities of microbes involved in biodegradation. Therefore, this study was undertaken to quantitatively assess the effects of heavy metals (arsenic, cadmium, mercury, and lead) on 1,2-DCA biodegradation in co-contaminated water. The minimum inhibitory concentrations (MICs) and concentrations of the heavy metals that caused half-life doubling (HLDs) of 1,2-DCA as well as the degradation rate coefficient (k(1)) and half-life (t(½)) of 1,2-DCA were measured and used to predict the toxicity of the heavy metals in the water microcosms. An increase in heavy metal concentration resulted in a progressive increase in the t(½) and relative t(½) and a decrease in k(1). The MICs and HLDs of the heavy metals were found to vary, depending on the heavy metals type. In addition, the presence of heavy metals was shown to inhibit 1,2-DCA biodegradation in a dose-dependent manner, with the following order of decreasing inhibitory effect: Hg(2+)  > As(3+)  > Cd(2+)  > Pb(2+). Findings from this study have significant implications for the development of bioremediation strategies for effective degradation of 1,2-DCA and other related compounds in wastewater co-contaminated with heavy metals.

  15. Fluorescent property of 3-hydroxymethyl imidazo[1,2-a]pyridine and pyrimidine derivatives

    Directory of Open Access Journals (Sweden)

    Velázquez-Olvera Stephania

    2012-08-01

    Full Text Available Abstract Background Imidazo[1,2-a]pyridines and pyrimidines are important organic fluorophores which have been investigated as biomarkers and photochemical sensors. The effect on the luminescent property by substituents in the heterocycle and phenyl rings, have been studied as well. In this investigation, series of 3-hydroxymethyl imidazo[1,2-a]pyridines and pyrimidines were synthesized and evaluated in relation to fluorescence emission, based upon the hypothesis that the hydroxymethyl group may act as an enhancer of fluorescence intensity. Results Compounds of both series emitted light in organic solvents dilutions as well as in acidic and alkaline media. Quantitative fluorescence spectroscopy determined that both fused heterocycles fluoresced more intensely than the parent unsubstituted imidazo[1,2-a]azine fluorophore. In particular, 3-hydroxymethyl imidazo[1,2-a]pyridines fluoresced more intensely than 3-hydroxymethyl imidazo[1,2-a]pyrimidines, the latter emitting blue light at longer wavelengths, whereas the former emitted purple light. Conclusion It was concluded that in most cases the hydroxymethyl moiety did act as an enhancer of the fluorescence intensity, however, a comparison made with the fluorescence emitted by 2-aryl imidazo[1,2-a]azines revealed that in some cases the hydroxymethyl substituent decreased the fluorescence intensity.

  16. Mechanism of 1,2-shift through p -complex transition state

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A systematic calculation of the potential curves or surfaces for 1,2-shift has been realized by using MNDO or other models in MOPAC programs. By referring to the previous authors' viewpoints, the 1,2-shift can be divided into two categories. 1,2-electron-deficient shift is that the electronic configuration of the atom which accepts the migrating group is a cation or an electron- deficient atom, and 1,2-anion shift is the one that the accepted atom of the migration group is a negative ion. In terms of the experimental facts and the calculation of the potential surfaces, in electron-deficient shift such as Beckmann or Baeyer-Villiger rearrangement, the migration occurs through a transition complex formed between the p -bond and the cation or electron-deficient migrating group, but in anion shift such as Wittig or Stevens rearrangement, the electron pair in p -orbit excites at first to p * orbit, and then the migration occurs through the new formed complex between the anion migration group and the vacant p orbit. The above mechanisms explain reasonably the intramolecular properties, the configuration retentions of the migration group, and the corresponding migratory aptitudes of the two type 1,2-shifts. The partial and less important free radical reaction of 1,2-anion shift has been explained by the p -complex mechanism too.

  17. Holmium-doped ZBLAN fiber lasers at 1.2 μm

    Science.gov (United States)

    Zhu, X.; Zong, J.; Norwood, R. A.; Chavez-Person, A.; Peyghambarian, N.; Prasad, N.

    2012-02-01

    Holmium (Ho3+)-doped ZBLAN glasses have been investigated for the purpose of achieving efficient fiber lasers at 1.2 μm. Because of the long lifetime of the upper laser level and the small phonon energy in Ho3+-doped ZBLAN glasses, strong fluorescence at 1.2 μm that usually cannot be observed in Ho-doped silica glass has been measured. Fluorescence of 1 mol%, 3 mol%, and 6 mol% Ho3+-doped ZBLAN glasses are reported. The effect of cerium and terbium ions on the emission of Ho3+-doped ZBLAN glass has also been studied. Obstacles to achieving an efficient Ho3+-doped ZBLAN laser are analyzed and discussed. In studies of a commercial Ho3+-doped ZBLAN fiber laser, it was found that the 3 μm four-energy-level laser can easily overwhelm the 1.2 μm laser, which is a three-energy-level system having the same upper laser level with the 3 μm laser. In order to effectively suppress the competiting 3 μm transition, advanced Ho3+-doped ZBLAN fiber has been designed and fabricated for 1.2 μm fiber lasers. Fiber lasers at 1.2 μm using the new Ho3+-doped ZBLAN fiber have been developed. Our experiments demonstrate that the new Ho3+-doped ZBLAN fiber is an efficient gain medium for lasers at 1.2 μm.

  18. Risky use of alcohol, drugs and cigarettes in a psychosis unit: a 1 1/2 year follow-up of stability and changes after initial screening

    Directory of Open Access Journals (Sweden)

    Öjehagen Agneta

    2007-07-01

    Full Text Available Abstract Background Co-morbidity with substance use disorders negatively influences overall functioning in patients with psychosis. However, frequencies and courses of risky use of alcohol, drugs and cigarettes are rarely investigated in patients at psychosis units. The purpose of this study is to describe the use of alcohol, drugs and cigarettes in patients at a psychosis unit over a 1 1/2 year period after them having taken part in a screening investigation including a feed-back of the results to personnel. Relationships with sex and age are also described. Methods The patients' use of the substances was examined at baseline and at follow-up using three self-reporting instruments: Alcohol Use Disorders Identification Test (AUDIT, Drug Use Disorders Identification Test (DUDIT and Fagerstrom Test for Nicotine Dependence (FTND. Results One hundred and eighty-six patients out of 238 at baseline (78 percent took part in the follow-up. Total AUDIT score decreased in women. Older men more often developed a risky alcohol use. Older women tended to reduce their risky drug habits. On a group level the habits mostly were stable, but 11 percent changed their alcohol habits and 15 percent changed their smoking habits from risky to no/low risky use, or vice versa. Nine percent changed their drug habits, predominantly from risky to no/low risky use. Conclusion A more active approach towards alcohol, drug and smoking habits in psychosis units would probably be beneficial.

  19. Chymase-dependent generation of angiotensin II from angiotensin-(1-12 in human atrial tissue.

    Directory of Open Access Journals (Sweden)

    Sarfaraz Ahmad

    Full Text Available Since angiotensin-(1-12 [Ang-(1-12] is a non-renin dependent alternate precursor for the generation of cardiac Ang peptides in rat tissue, we investigated the metabolism of Ang-(1-12 by plasma membranes (PM isolated from human atrial appendage tissue from nine patients undergoing cardiac surgery for primary control of atrial fibrillation (MAZE surgical procedure. PM was incubated with highly purified ¹²⁵I-Ang-(1-12 at 37°C for 1 h with or without renin-angiotensin system (RAS inhibitors [lisinopril for angiotensin converting enzyme (ACE, SCH39370 for neprilysin (NEP, MLN-4760 for ACE2 and chymostatin for chymase; 50 µM each]. ¹²⁵I-Ang peptide fractions were identified by HPLC coupled to an inline γ-detector. In the absence of all RAS inhibitor, ¹²⁵I-Ang-(1-12 was converted into Ang I (2±2%, Ang II (69±21%, Ang-(1-7 (5±2%, and Ang-(1-4 (2±1%. In the absence of all RAS inhibitor, only 22±10% of ¹²⁵I-Ang-(1-12 was unmetabolized, whereas, in the presence of the all RAS inhibitors, 98±7% of ¹²⁵I-Ang-(1-12 remained intact. The relative contribution of selective inhibition of ACE and chymase enzyme showed that ¹²⁵I-Ang-(1-12 was primarily converted into Ang II (65±18% by chymase while its hydrolysis into Ang II by ACE was significantly lower or undetectable. The activity of individual enzyme was calculated based on the amount of Ang II formation. These results showed very high chymase-mediated Ang II formation (28±3.1 fmol × min⁻¹ × mg⁻¹, n = 9 from ¹²⁵I-Ang-(1-12 and very low or undetectable Ang II formation by ACE (1.1±0.2 fmol×min⁻¹ × mg⁻¹. Paralleling these findings, these tissues showed significant content of chymase protein that by immunocytochemistry were primarily localized in atrial cardiac myocytes. In conclusion, we demonstrate for the first time in human cardiac tissue a dominant role of cardiac chymase in the formation of Ang II from Ang-(1-12.

  20. Mitigation of EMI/RFI produced by a 1.2 kW uninterruptible power supply

    Science.gov (United States)

    Mikros, Efthimios

    1993-09-01

    Recently installed equipment in naval receiving sites, such as Uninterruptible Power Supplies (UPS), digital telephone switching systems, and personal computers, inject noise into receiver systems via power conductors, cable shields, and grounds, thus reducing the probability of intercept of a signal of interest in the 2-100 NMHz range. In this thesis a survey of EMI/RFI sources at receiving sites is performed. The effectiveness of a Barrier-Filter-Ground architecture in containing/eliminating EMI/RFI from a 1.2 kW UPS is tested. The spectral and temporal properties of the EMI/RFI from the UPS are recorded. Estimates for the EMI/RFI power are obtained from 60Hz to 100kHz, and a possible solution is proposed for obtaining noise power estimates for higher frequencies.

  1. Surgery strategy about C1-2 dumbbell tumor%C1-2哑铃型肿瘤的手术治疗

    Institute of Scientific and Technical Information of China (English)

    马长城; 王振宇; 于涛

    2011-01-01

    目的:研究C1-2哑铃型肿瘤的手术方式以及手术对颈椎稳定性的影响.方法:回顾分析北京大学第三医院神经外科2007年1月至2010年7月收治的C1-2哑铃型肿瘤手术病例共16例,根据肿瘤的大小和侵及范围选择不同手术方式切除肿瘤.常规病人先行俯卧位,首先行后正中半椎板人路切除椎管内外肿瘤,充分显露肿瘤后,切除硬膜外部分,待有足够空间,再切除硬膜下部分;如果肿瘤在椎管内部分超过椎管的一半以上,则须切除部分C1-2棘突基底以利显露手术区域,以防脊髓损伤.硬膜如有缺损则需修补,肌肉缝合要做到解剖复位,以利颈椎的稳定性;如果肿瘤侵及椎管外超过4 cm或完全包绕椎动脉Ⅰ期手术无法全切,则需再联合侧方人路切除肿瘤.结果:共治疗C1-2哑铃型肿瘤16例,其中神经鞘瘤12例,脊膜瘤3例,神经节细胞瘤1例;全切除14例,次全切除2例.病人术后颈部疼痛、上肢肌肉无力等症状均有明显缓解.术后随访3~48个月,未出现颈椎不稳定和肿瘤复发.结论:后正中半椎板入路或联合侧方入路能较好地切除C1-2哑铃型肿瘤,同时能较好地保持颈椎的稳定性.%Objective : To study the operation of C1-2 dumbbell-shaped tumor, and its effect on the cervical spine stability. Methods: Different surgical tumor resection was selected according to the tumor size and the invasion scope. Hemilaminectomy was the first choice for the resection of the tumor at intr-extraspinal canal in the conventional prone position . After the tumor was fully revealed, the epidural tumor was removed first with enough space to be vacated, then the subdural section was removed . If the tumor in the spinal canal was more than half of the spinal canal, to prevent spinal cord injury, the part of the C1-2 spinous process base should be removed to facilitate the exposure. Dural defect should be repaired and the muscle sutured to achieve anatomic reduction in order to facilitate the stability of the cervical spine. Lateral approach should be combined to resect the tumor if its total removal was impossible as the tumor had invaded the spinal canal outside over 4 cm or completely surrounded the vertebral artery. Results : C1-2 dumbbell-type tumors were treated in 16 cases, of which 12 were of schwannoma, 3 of meningioma and 1 of ganglion cell tumor. Total resection was in 14 cases, and subtotal resection in 2. After operation, the symptoms of pain in the neck and upper limb muscle weakness were relieved. All the patients were followed up. The follow-up period was 3 -48 months. No cervical spine instability or tumor recurrence was found. Conclusion: C 1-2 dumbbell-shaped tumors could be well resected by poster-median hemilamiectomy approach or joint lateral approach , and the stability of cervical spine could be better maintained at the same time.

  2. Method of JQuery Mobile 1.2 in mobile Web development%JQuery Mobile 1.2移动Web开发方法研究

    Institute of Scientific and Technical Information of China (English)

    徐尤华; 熊传玉

    2013-01-01

    With the rapidly growing popularity of smart devices such as iphone and Android,mobile web technology has gradually become a new hot spot of concern,traditional site will be transferred to the mobile terminal due to market demand.Traditional website can not adapt to terminal,mobile web development is becoming a popular subject.JQuery Mobile 1.2 final released on October,2012,has many advantages,such as to get started quickly,support rapid iteration,support cross-platform and crossdevice development.Will become a main UI frame in mobile web development.Understand features,accessibility,supported plafforms of JQuery Mobile 1.2,the scope of the framework can be clearly.Master pages,dialogs,toolbars,buttons,content formatting,form elements,list views,API and other content,you can create a functional and beautiful mobile web page quickly.%随着iphone、Android等智能设备的迅速普及,移动Web技术逐渐成为关注的新热点,传统信息类和电子商务网站因市场需求向移动终端转移.由于传统网站在终端不能很好地适应,移动Web开发逐渐成为一门热门学科.JQuery Mobile 1.2正式版于2012年10月正式发布,其具有上手迅速并支持快速迭代、支持跨平台和跨设备开发等优点,将会成为移动Web开发中UI开发的主流框架.通过对JQuery Mobile 1.2的主要特性、易用性、支持的平台的了解,可以明确该框架的适用范围.掌握页面、对话框、工具栏、按钮、内容格式化、表单元素、列表、API等主要内容后,可以快速制作出实用且漂亮的移动Web页面.

  3. Isaiah 1:2−3, ethics and wisdom. Isaiah 1:2–3 and the Song of Moses (Dt 32: Is Isaiah a prophet like Moses?

    Directory of Open Access Journals (Sweden)

    Alphonso Groenewald

    2011-06-01

    Full Text Available This article argued that society even today could benefit from the richness of the ethics of the Hebrew Bible. Isaiah 1:2–3 has been used as an example to illustrate the ethics of a biblical text. This text has wisdom traits and literary links with Deuteronomy 32. In a modern, pluralistic society there is a need for a comprehensive ethical view by which one can combine a solid religious foundation, including responsibility towards God, the Creator and Lord of life, with a broad human wisdom gained from a rational understanding of the circumstances of existence for a true human life in a created world of order.

  4. Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium.

    Science.gov (United States)

    Paul, Jonathan; Maiti, Kaushik; Read, Mark; Hure, Alexis; Smith, Julia; Chan, Eng-Cheng; Smith, Roger

    2011-01-01

    Human myometrium develops phasic contractions during labor. Phosphorylation of caldesmon (h-CaD) and extracellular signal-regulated kinase 1/2 (ERK 1/2) has been implicated in development of these contractions, however the phospho-regulation of these proteins is yet to be examined during periods of both contraction and relaxation. We hypothesized that protein phosphorylation events are implicated in the phasic nature of myometrial contractions, and aimed to examine h-CaD and ERK 1/2 phosphorylation in myometrium snap frozen at specific stages, including; (1) prior to onset of contractions, (2) at peak contraction and (3) during relaxation. We aimed to compare h-CaD and ERK 1/2 phosphorylation in vitro against results from in vivo studies that compared not-in-labor (NIL) and laboring (L) myometrium. Comparison of NIL (n = 8) and L (n = 8) myometrium revealed a 2-fold increase in h-CaD phosphorylation (ser-789; P = 0.012) during onset of labor in vivo, and was associated with significantly up-regulated ERK2 expression (P = 0.022), however no change in ERK2 phosphorylation was observed (P = 0.475). During in vitro studies (n = 5), transition from non-contracting tissue to tissue at peak contraction was associated with increased phosphorylation of both h-CaD and ERK 1/2. Furthermore, tissue preserved at relaxation phase exhibited diminished levels of h-CaD and ERK 1/2 phosphorylation compared to tissue preserved at peak contraction, thereby producing a phasic phosphorylation profile for h-CaD and ERK 1/2. h-CaD and ERK 1/2 are phosphorylated during myometrial contractions, however their phospho-regulation is dynamic, in that h-CaD and ERK 1/2 are phosphorylated and dephosphorylated in phase with contraction and relaxation respectively. Comparisons of NIL and L tissue are at risk of failing to detect these changes, as L samples are not necessarily preserved in the midst of an active contraction.

  5. Systematically engineering Escherichia coli for enhanced production of 1,2-propanediol and 1-propanol.

    Science.gov (United States)

    Jain, Rachit; Sun, Xinxiao; Yuan, Qipeng; Yan, Yajun

    2015-06-19

    The biological production of high value commodity 1,2-propanediol has been established by engineering the glycolysis pathway. However, the simultaneous achievement of high titer and high yield has not been reported yet, as all efforts in increasing the titer have resulted in low yields. In this work, we overcome this limitation by employing an optimal minimal set of enzymes, channeling the carbon flux into the 1,2-propanediol pathway, increasing NADH availability, and improving the anaerobic growth of the engineered Escherichia coli strain by developing a cell adaptation method. These efforts lead to 1,2-propanediol production at a titer of 5.13 g/L with a yield of 0.48 g/g glucose in 20 mL shake flask studies. On this basis, we pursue the enhancement of 1-propanol production from the 1,2-propanediol platform. By constructing a fusion diol dehydratase and developing a dual strain process, we achieve a 1-propanol titer of 2.91 g/L in 20 mL shake flask studies. To summarize, we report the production of 1,2-propanediol at enhanced titer and enhanced yield simultaneously in E. coli for the first time. Furthermore, we establish an efficient system for the production of biofuel 1-propanol biologically.

  6. Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas

    Institute of Scientific and Technical Information of China (English)

    YU Lei; QI Song-tao; LI Zhi-yong

    2010-01-01

    Objective To highlight recent researches which may show promise for histomolecular classification and new treatments for gliomas.Data sources All articles cited in this review were mainly searched from PubMed, which were published in English from 1996 to 2010.Study selection Original articles and critical reviews selected were relevant to the isocitrate dehydrogenase-1/2 mutation in gliomas and other tumors.Results Extraordinary high rates of somatic mutations in isocitrate dehydrogenase-1/2 occur in the majority of World Health Organization grade Ⅱ and grade Ⅲ gliomas as well as grade Ⅳ secondary glioblastomas. Isocitrate dehydrogenase-1/2 mutations are associated with younger age at diagnosis and a better prognosis in patients with mutated tumors. The functional role of isocitrate dehydrogenase-1/2 mutations in the pathogenesis of gliomas is still unclear.Conclusion Isocitrate dehydrogenase-1/2 mutations define a specific subtype of gliomas and may have great significance in the diagnosis, prognosis, and treatment of patients with these tumors.

  7. Hydrogenolysis of Glycerol to 1,2-Propanediol Over Clay Based Catalysts.

    Science.gov (United States)

    Lee, Sang-Yong; Jung, Jae-Sun; Yang, Eun-Hyeok; Lee, Kwan-Young; Moon, Dong Ju

    2015-11-01

    1,2-propanediol (1,2-PDO) is one of the promising product among the valuable products derived from glycerol and it can be obtained by the catalytic hydrogenolysis of glycerol. Copper-supported clay-based catalysts were prepared with different pore sizes using various ratios of kaolin, Mg, and Al by coprecipitation and applied in the selective hydrogenolysis of glycerol to 1,2-PDO. In recent research, variations of pore volume and pore size could affect the diffusion of reagents within the catalyst due to the collision between reagents or pore wall and reagents. It changes selectivities of each product in hydrogenolysis of glycerol reaction. The physico-chemical properties of the catalysts were analyzed by XRD, N2 physisorption, TPR, CO2-TPD, SEM, and a mercury porosimeter. The Cu/TALCITE 4 catalyst showed 98% 1,2-PDO selectivity with 65% glycerol conversion under the optimized condition of 190 degrees C, 25 bar, and 20 wt% glycerol aqueous solution. It was found that the basic strength and meso-macro pore structure of the catalysts play an important role in glycerol conversion and 1,2-PDO selectivity.

  8. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    Science.gov (United States)

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.

  9. Production of 1,2-didocosahexaenoyl phosphatidylcholine by bonito muscle lysophosphatidylcholine/transacylase.

    Science.gov (United States)

    Hirano, Kaoru; Matsui, Hidetoshi; Tanaka, Tamotsu; Matsuura, Fumito; Satouchi, Kiyoshi; Koike, Tohru

    2004-10-01

    1,2-Didocosahexaenoyl phosphatidylcholine (PC), which has highly unsaturated fatty acid at both sn-1 and sn-2 positions of glycerol, is a characteristic molecular species of bonito muscle. To examine the involvement of a de novo route in its synthesis, the molecular species of phosphatidic acid (PA) were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato dizinc(II) complex, a novel phosphate-capture molecule. However, 1,2-didocosahexaenoyl species could not be detected. Next, 1,2-didocosahexaenoyl PC synthesis by the cytosolic lysophosphatidylcholine (LPC)/transacylase was examined using endogenous LPC from bonito muscle, in which the 2-docosahexaenoyl species is abundant. The LPC/transacylase synthesized 1,2-didocosahexaenoyl PC as the most abundant molecular species. For further characterization, the LPC/transacylase was purified to homogeneity from the 100,000 x g supernatant of bonito muscle. The isolated LPC/transacylase is a labile glycoprotein with molecular mass of 52 kDa including a 5-kDa sugar moiety. The LPC/transacylase showed a PC synthesis (transacylase activity) below and above the critical micelle concentration of substrate LPC, and fatty acid release (lysophospholipase activity) was always smaller than the transacylase activity, even with a monomeric substrate. These results suggest that the LPC/transacylase is responsible for the synthesis of 1,2-didocosahexaenoyl PC.

  10. Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

    Science.gov (United States)

    Subashini, R.; Bharathi, A.; Roopan, Selvaraj Mohana; Rajakumar, G.; Abdul Rahuman, A.; Gullanki, Pavan Kumar

    Acridin-1(2H)-one analogue of 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridine-2yl) methylene] acridin-1(2H)-one, 5 was prepared by using 7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one, 3 and picolinaldehyde, 4 in the presence of KOH at room temperature. These compounds were characterized by analytical and spectral analyses. The purpose of the present study was to assess the efficacy of larvicidal and repellent activity of synthesized 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues such as compounds 3 and 5 against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae). The compound exhibited high larvicidal effects at 50 mg/L against both the mosquitoes with LC50 values of 25.02 mg/L (r2 = 0.998) and 26.40 mg/L (r2 = 0.988) against C. quinquefasciatus and C. gelidus, respectively. The 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues that are reported for the first time to our best of knowledge can be better explored for the control of mosquito population. This is an ideal ecofriendly approach for the control of Japanese encephalitis vectors, C. quinquefasciatus and C. gelidus.

  11. The continuum limit of $a_{N-1}^{(2)}$ spin chains

    CERN Document Server

    Vernier, Eric; Saleur, Hubert

    2016-01-01

    Building on our previous work for $a_2^{(2)}$ and $a_3^{(2)}$ we explore systematically the continuum limit of gapless $a_{N-1}^{(2)}$ vertex models and spin chains. We find the existence of three possible regimes. Regimes I and II for $a_{2n-1}^{(2)}$ are related with $a_{2n-1}^{(2)}$ Toda, and described by $n$ compact bosons. Regime I for $a_{2n}^{(2)}$ is related with $a_{2n}^{(2)}$ Toda and involves $n$ compact bosons, while regime II is related instead with $B^{(1)}(0,n)$ super Toda, and involves in addition a single Majorana fermion. The most interesting is regime III, where {\\sl non-compact} degrees of freedom appear, generalising the emergence of the Euclidean black hole CFT in the $a_{2}^{(2)}$ case. For $a_{2n}^{(2)}$ we find a continuum limit made of $n$ compact and $n$ non-compact bosons, while for $a_{2n-1}^{(2)}$ we find $n$ compact and $n-1$ non-compact bosons. We also find deep relations between $a_{N-1}^{(2)}$ in regime III and the gauged WZW models $SO(N)/SO(N-1)$.

  12. Enzyme IIANtr Regulates Salmonella Invasion Via 1,2-Propanediol And Propionate Catabolism

    Science.gov (United States)

    Yoo, Woongjae; Kim, Dajeong; Yoon, Hyunjin; Ryu, Sangryeol

    2017-01-01

    Many Proteobacteria possess a nitrogen-metabolic phosphotransferase system (PTSNtr) consisting of EINtr, NPr, and EIIANtr (encoded by ptsP, ptsO, and ptsN, respectively). The PTSNtr plays diverse regulatory roles, but the substrate phosphorylated by EIIANtr and its primary functions have not yet been identified. To comprehensively understand the roles of PTSNtr in Salmonella Typhimurium, we compared the whole transcriptomes of wild-type and a ΔptsN mutant. Genome-wide RNA sequencing revealed that 3.5% of the annotated genes were up- or down-regulated by three-fold or more in the absence of EIIANtr. The ΔptsN mutant significantly down-regulated the expression of genes involved in vitamin B12 synthesis, 1,2-propanediol utilization, and propionate catabolism. Moreover, the invasiveness of the ΔptsN mutant increased about 5-fold when 1,2-propanediol or propionate was added, which was attributable to the increased stability of HilD, the transcriptional regulator of Salmonella pathogenicity island-1. Interestingly, an abundance of 1,2-propanediol or propionate promoted the production of EIIANtr, suggesting the possibility of a positive feedback loop between EIIANtr and two catabolic pathways. These results demonstrate that EIIANtr is a key factor for the utilization of 1,2-propanediol and propionate as carbon and energy sources, and thereby modulates the invasiveness of Salmonella via 1,2-propanediol or propionate catabolism. PMID:28333132

  13. Key role of ERK1/2 molecular scaffolds in heart pathology.

    Science.gov (United States)

    Tarone, Guido; Sbroggiò, Mauro; Brancaccio, Mara

    2013-11-01

    The ability of cardiomyocytes to detect mechanical and humoral stimuli is critical for adaptation of the myocardium in response to new conditions and for sustaining the increased workload during stress. While certain stimuli mediate a beneficial adaptation to stress conditions, others result in maladaptive remodelling, ultimately leading to heart failure. Specific signalling pathways activating either adaptive or maladaptive cardiac remodelling have been identified. Paradoxically, however, in a number of cases, the transduction pathways involved in such opposing responses engage the same signalling proteins. A notable example is the Raf-MEK1/2-ERK1/2 signalling pathway that can control both adaptive and maladaptive remodelling. ERK1/2 signalling requires a signalosome complex where a scaffold protein drives the assembly of these three kinases into a linear pathway to facilitate their sequential phosphorylation, ultimately targeting specific effector molecules. Interestingly, a number of different Raf-MEK1/2-ERK1/2 scaffold proteins have been identified, and their role in determining the adaptive or maladaptive cardiac remodelling is a promising field of investigation for the development of therapeutic strategies capable of selectively potentiating the adaptive response.

  14. Structure basis 1/2SLPI and porcine pancreas trypsin interaction

    Energy Technology Data Exchange (ETDEWEB)

    Fukushima, Kei; Kamimura, Takashi; Takimoto-Kamimura, Midori, E-mail: m.kamimura@teijin.co.jp [Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka, Hino-shi, Tokyo 191-8512 (Japan)

    2013-11-01

    1/2SLPI is a C-terminal domain of SLPI (secretory leukocyte protease inhibitor) which inhibits various serine proteases broadly. The present study is the first X-ray structural report on how 1/2SLPI with P1 Leu strongly inhibits trypsin and how it can inhibit multiple serine proteases. SLPI (secretory leukocyte protease inhibitor) is a 107-residue protease inhibitor which inhibits various serine proteases, including elastase, cathepsin G, chymotrypsin and trypsin. SLPI is obtained as a multiple inhibitor in lung defense and in chronic airway infection. X-ray crystal structures have so far reported that they are full-length SLPIs with bovine α-chymotrypsin and 1/2SLPI (recombinant C-terminal domain of SLPI; Arg58–Ala107) with HNE (human neutrophil elastase). To understand the role of this multiple inhibitory mechanism, the crystal structure of 1/2SLPI with porcine pancreas trypsin was solved and the binding modes of two other complexes compared. The Leu residue surprisingly interacts with the S1 site of trypsin, as with chymotrypsin and elastase. The inhibitory mechanism of 1/2SLPI using the wide primary binding site contacts (from P2′ to P5) with various serine proteases is discussed. These inhibitory mechanisms have been acquired in the evolution of the protection system for acute inflammatory diseases.

  15. Evaluation of Calypte AWARE HIV-1/2 OMT antibody test as a screening test in an Indian setting.

    Science.gov (United States)

    Ingole, N A; Mehta, P R; Bande, R N; Paranjpe, S M; Wanjare, S W

    2010-01-01

    Integrated counselling and testing centres (ICTC) provide counselling and blood testing facilities for HIV diagnosis. Oral fluid tests provide an alternative for people who do not want blood to be drawn. Also, it avoids the risk of occupational exposure. The goal of this study was to evaluate the utility of Calypte AWARE HIV-1/2 OMT antibody test as a screening test in an Indian setting. A cross-sectional study was carried out after ethics committee approval in 250 adult ICTC clients. Blood was collected and tested from these clients for HIV diagnosis as per routine policy and the results were considered as the gold standard. Also, after another written informed consent, oral fluid was collected from the clients and tested for the presence of HIV antibodies. Twenty five clients who had and 25 clients who had not completed their secondary school education (Group A and Group B, respectively) were also asked to perform and interpret the test on their own and their findings and experiences were noted. The sensitivity, specificity, PPV and NPV of the oral fluid antibody test were 100%, 98.51%, 94.11% and 100%, respectively. Seventy six percent of clients preferred oral fluid testing. Group B found it difficult to perform the test as compared to Group A and this difference was statistically significant (P ≤ 0.05). Oral fluid testing can be used as a screening test for HIV diagnosis; however, confirmation of reactive results by blood-based tests is a must.

  16. Near Zero Emissions at 50 Percent Thermal Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-12-31

    Detroit Diesel Corporation (DDC) has successfully completed a 10 year DOE sponsored heavy-duty truck engine program, hereafter referred to as the NZ-50 program. This program was split into two major phases. The first phase was called Near-Zero Emission at 50 Percent Thermal Efficiency, and was completed in 2007. The second phase was initiated in 2006, and this phase was named Advancements in Engine Combustion Systems to Enable High-Efficiency Clean Combustion for Heavy-Duty Engines. This phase was completed in September, 2010. The key objectives of the NZ-50 program for this first phase were to: Quantify thermal efficiency degradation associated with reduction of engine-out NOx emissions to the 2007 regulated level of ~1.1 g/hp-hr. Implement an integrated analytical/experimental development plan for improving subsystem and component capabilities in support of emerging engine technologies for emissions and thermal efficiency goals of the program. Test prototype subsystem hardware featuring technology enhancements and demonstrate effective application on a multi-cylinder, production feasible heavy-duty engine test-bed. Optimize subsystem components and engine controls (calibration) to demonstrate thermal efficiency that is in compliance with the DOE 2005 Joule milestone, meaning greater than 45% thermal efficiency at 2007 emission levels. Develop technology roadmap for meeting emission regulations of 2010 and beyond while mitigating the associated degradation in engine fuel consumption. Ultimately, develop technical prime-path for meeting the overall goal of the NZ-50 program, i.e., 50% thermal efficiency at 2010 regulated emissions. These objectives were successfully met during the course of the NZ-50 program. The most noteworthy achievements in this program are summarized as follows: Demonstrated technologies through advanced integrated experiments and analysis to achieve the technical objectives of the NZ-50 program with 50.2% equivalent thermal efficiency under

  17. The [OII]3727 Luminosity function and Star Formation Rate at z~1.2 in the COSMOS 2 Square-degree Field and the Subaru Deep Field

    CERN Document Server

    Takahashi, M I; Taniguchi, Y; Murayama, T; Ajiki, M; Sasaki, S S; Koizumi, O; Nagao, T; Scoville, N Z; Mobasher, B; Aussel, H; Capak, P; Carilli, C; Ellis, Richard S; Garilli, B; Giavalisco, M; Guzzo, L; Hasinger, G; Impey, C; Kitzbichler, M G; Koekemoer, A; Lefèvre, O; Lilly, S J; MacCagni, D; Renzini, A; Rich, M; Sanders, D B; Schinnerer, E; Scodeggio, M; Shopbell, P; Smolcic, V; Tribiano, S; Ideue, Y; Mihara, S

    2007-01-01

    We have carried out a wide-field imaging survey for [OII]3727 emitting galaxies at z~1.2 in the HST COSMOS 2 square degree field using the Suprime-Cam on the Subaru Telescope. The survey covers a sky area of 6700 arcmin^2 in the COSMOS field, and a redshift range between 1.17 and 1.20 (Delta_z = 0.03), corresponding to a survey volume of 5.56*10^5 Mpc^3. We obtain a sample of 3176 [OII] emitting galaxies with observed emission-line equivalent widths greater than 26 AA. Since our survey tends to sample brighter [OII]3727 emitting galaxies, we also analyze a sample of fainter [OII]3727 emitting galaxies found in the Subaru Deep Field (SDF). We find an extinction-corrected [OII] luminosity density of 10^{40.35^+0.08_-0.06} ergs s^-1 Mpc-3, corresponding to star formation rate density of 0.32^+0.06_-0.04 M_sun yr-1 Mpc^-3 in the COSMOS field at z~1.2. This is the largest survey for [OII]3727 emitters beyond z=1 currently available.

  18. Structural and electrical properties of Na{sub 1/2}La{sub 1/2}TiO{sub 3} ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Barik, S.K.; Mahapatra, P.K. [Vidyasagar University, Department of Physics and Technophysics, Midnapur, West Bengal (India); Choudhary, R.N.P. [Department of Physics and Meteorology, I.I.T. Kharagpur (India)

    2006-11-15

    Na{sub 1/2}La{sub 1/2}TiO{sub 3} (NLT) ceramic was prepared by a high-temperature solid-state reaction technique. A preliminary structural analysis (XRD) suggested the formation of a single-phase orthorhombic structure. SEM micrograph of the material showed uniform grain distribution on the surface of the sample. The dielectric permittivity and the loss tangent of the sample were measured in a frequency range from 1 kHz to 1 MHz and a temperature range 28 C to 525 C. Electrical properties of the material were studied using an ac impedance spectroscopic technique. Detailed analysis of the impedance spectrum suggested that the electrical properties of the material are strongly temperature dependant. The Nyquist plots clearly showed the presence of both bulk and grain boundary effect in the compound. The activation energy was estimated to be 1.1 eV from the temperature variation of dc conductivity. The a.c. conductivity spectrum suggests a typical signature of ion conducting system. (orig.)

  19. Impedance spectroscopy study of Na{sub 1/2}Sm{sub 1/2}TiO{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Barik, S.K.; Choudhary, R.N.P. [I.I.T., Department of Physics and Meteorology, Kharagpur (India); Mahapatra, P.K. [Vidyasagar University, Department of Physics and Technophysics, Midnapur, West Bengal (India)

    2007-07-15

    Complex impedance analysis of a valence-compensated perovskite ceramic oxide Na{sub 1/2}Sm{sub 1/2}TiO{sub 3}, prepared by a mixed oxide (solid-state reaction) method, has been carried out. The formation of single-phase material was confirmed by X-ray diffraction studies, and it was found to be an orthorhombic phase at room temperature. In a scanning electron microscope, grains separated by well-defined boundaries are visible, which is in good agreement with that of impedance analysis. Alternating current impedance measurements were made over a wide temperature range (31-400 C) in an air atmosphere. Complex impedance and modulus plots helped to separate out the contributions of grain and grain boundaries to the overall polarization or electrical behavior. The physical structure of the samples was visualized most prominently at higher temperatures (275 C) from the Nyquist plots showing inter- and intragranular impedance present in the material. The frequency dependence of electrical data is also analyzed in the framework of the conductivity and modulus formalisms. The bulk resistance, evaluated from the impedance spectrum, was observed to decrease with rise in temperature, showing a typical negative temperature coefficient of resistance-type behavior like that of semiconductors. The modulus mechanism indicates the non-Debye type of conductivity relaxation in the materials, which is supported by the impedance data. (orig.)

  20. Structural and electrical properties of Na{sub 1/2}Gd{sub 1/2}TiO{sub 3} nanoceramics

    Energy Technology Data Exchange (ETDEWEB)

    Barik, Subrat K. [Department of Physics and Meteorology, IIT Kharagpur, Kharagpur 721302 (India); Choudhary, R.N.P. [Department of Physics and Meteorology, IIT Kharagpur, Kharagpur 721302 (India)], E-mail: crnpfl@phy.iitkgp.ernet.in; Mahapatra, P.K. [Department of Physics and Technophysics, Vidyasagar University, Midnapur 721102, West Bengal (India)

    2008-07-14

    The polycrystalline fine (i.e., 38 nm) powder of Na{sub 1/2}Gd{sub 1/2}TiO{sub 3} was prepared by a high-temperature solid-state reaction technique. The formation of single phase compound was confirmed by an X-ray diffraction technique. A preliminary structural analysis exhibited the orthogonal crystal structure of the compound. The surface morphology was studied by scanning electron microscopy. The dielectric permittivity and the loss tangent of the pellet sample were obtained in a wide frequency range (1 kHz-1 MHz) at different temperatures (28-500 deg. C). A dielectric anomaly was observed at 73 deg. C which may be related to ferroelectric-paraelectric phase transition. The ferroelectric transition was confirmed by observation of hysteresis loop at room temperature. Electrical properties of the pellet sample were studied using an AC impedance spectroscopic technique. Detailed analysis of impedance spectra indicated the bulk contribution to electrical properties below 375 deg. C, and the grain boundary above 375 deg. C. The negative temperature coefficient of resistance (NTCR) effect and the temperature dependant electrical relaxation phenomenon in the sample were also observed. Studies of DC conductivity exhibited that the material has a thermally activated process. AC conductivity spectrum obeys Jonscher's universal power law.

  1. Studies of Thermal, Impedance and Magnetic Properties of (Bi1/2Na1/2)(Fe2/3W1/3)O3 Multiferroics

    Science.gov (United States)

    Ahmed, Suhel; Barik, Subrat Kumar

    2017-02-01

    A polycrystalline sample of (Bi1/2Na1/2)(Fe2/3W1/3)O3 was synthesized by high-temperature solid-state reaction technique. Calcination temperature and thermal stability of the material were analyzed by thermogravimetric analysis. X-ray diffraction analysis reveals a phase transformation from rhombohedral to orthorhombic due to Na and W co-doping in BFO. Electrical properties of the material were measured in a wide temperature range of 30-450°C, at different frequencies (100 Hz-1 MHz). Dielectric study revealed that the prepared material had a Neel temperature at 325°C. Direct current conductivity was found to obey the Arrhenius relationship. The value of activation energy was found to be 0.67 eV for the grain (175-450°C) and 0.94 eV for the grain boundary (200-450°C). The enhanced magnetic property of the synthesized material was evaluated from the magnetization-magnetic field loop study.

  2. Chemical pressure induced change in multiferroicity of Bi1+2xGd2x/2Fe1-2xO3 bulk ceramics

    Science.gov (United States)

    Pradhan, S. K.; Sahu, D. R.; Rout, P. P.; Das, S. K.; Pradhan, A. K.; Srinivasu, V. V.; Roul, B. K.

    2017-04-01

    We have optimized Gd ion substitution in BiFeO3 (BFO) and observed prominently change in structural, electrical and magnetic behavior of Bi1+2xGd2x/2Fe1-2xO3 ceramics synthesized through slow step sintering schedule. It is observed that with the increase in concentration of Gd (x=0.1), original structure of BFO is transformed from rhombohedral R3c space group to orthorhombic Pn21a space group. Surprisingly, unit cell volume is drastically contracted (35% for x=0.2) and the sintered specimen showed enhanced room temperature ferromagnetic behavior although the original BFO is normally G-type antiferromagnetic in nature at 643 K. It is expected that intrinsic chemical pressure within the bulk body built by the substitution of Gd in presence of excess bismuth greatly supported through unidirectional movement of electrical dipole moment with in each individual domain as a result of which suppression of leakage current with enhanced dielectric and ferroelectric hysteresis is observed.

  3. Fabrication and Electrical Properties of Multilayer Ceramic Actuator Using Lead-Free (Bi1/2K1/2)TiO3

    Science.gov (United States)

    Nagata, Hajime; Tabuchi, Kazuya; Takenaka, Tadashi

    2013-09-01

    A prototype of a multilayer actuator (MLA) was fabricated using (Bi1/2K1/2)TiO3 (BKT) ceramics as active layers and Ag-Pd (7:3) as inner electrodes. Then, their microstructures and electrical properties were investigated. From the scanning electron microscope (SEM) observation, the thickness of the BKT active layers between electrodes was estimated to be approximately 60 µm for the body co-fired at 1045 °C for 10 h. Also, SEM images showed homogeneous and dense microstructures on the BKT active layers. Additionally, the interface between BKT and the Ag-Pd electrode was clearly distinguished and there are no significant signs of reaction or diffusion between them at least from the SEM micrographs. The resistivity ρ of BKT sample co-fired at 1045 °C for 10 h was about 1011 Ω.cm on average, which is sufficient for applying a high DC electric field to the sample. From the measurement of the field-induce strain S under unipolar driving at 100 kV/cm, a large strain of 0.14% at 100 kV/cm was obtained and the longitudinal dynamic displacement was 1 µm at the same electric field. The normalized d33* was calculated to be 138 pm/V, which is similar to that in the bulk samples. This result indicates that the BKT-based multilayered prototype efficiently functioned under unipolar driving up to 100 kV/cm.

  4. Structural transitions in Pb(In1/2Nb1/2)O 3 under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Ahart, Muhtar [Carnegie Inst. of Washington, Washington, DC (United States); Somayazulu, Maddury [Carnegie Inst. of Washington, Washington, DC (United States); Kojima, Seiji [Gifu Univ. (Japan); Yasuda, Naohiko [Gifu Univ. (Japan); Prosandeev, Sergey [Univ. of Arkansas, Fayetteville, AR (United States). Inst. for Nanoscience and Engineering; Hemley, Russell J. [Carnegie Inst. of Washington, Washington, DC (United States)

    2015-12-01

    Room-temperature Raman scattering and x-ray diffraction measurements together with first-principles calculations were employed to investigate the behavior of disordered Pb(In1/2Nb1/2)O3 (PIN) under pressure up to 50GPa. Raman spectra show broad bands but a peak near the 380cm-1 increases its intensity with pressure. The linewidth of the band at 550cm-1 also increases with pressure, while two of the Raman peaks merge above 6GPa. Above 16GPa, we observe additional splitting of the band at 50cm-1. The pressure evolution of the diffraction patterns for PIN shows obvious Bragg peaks splitting above 16GPa; consistent with a symmetry lowering transition. The transition at 0.5GPa is identified as a pseudo-cubic to orthorhombic (Pbam) structural change whereas the transition at 16GPa is isostructure and associated with changes in linear compressibility and octahedral titling, and the transition at 30GPa is associated to an orthorhombic to monoclinic change. First-principles calculations indicate that the Pbam structure is ground state with antiferrodisdortion consistent with experiment.

  5. Effect of thermal history on stability of the relaxor state in (Bi1/2K1/2)TiO3 ceramics

    Science.gov (United States)

    Hagiwara, Manabu; Fujihara, Shinobu

    2017-10-01

    Bismuth potassium titanate (Bi1/2K1/2)TiO3 (BKT) with disordered A-site Bi3+ and K+ ions is known to undergo a spontaneous phase transition between a high-temperature relaxor (R) state and a low-temperature ferroelectric (FE) state at around 300 °C. Here, we demonstrate that the thermal history of BKT ceramics has a great effect on the stability of the R and FE states. To modulate the distribution of Bi3+ and K+ ions, as-sintered BKT ceramics were postannealed at 900 °C and then cooled to 500 °C at a very low cooling rate of ‑0.1 °C/min. The slowly cooled samples showed a normal-relaxor-like temperature dependence of dielectric permittivity without any anomaly attributed to the spontaneous R-FE transition. The slow cooling treatment changed the room-temperature crystal system of the BKT ceramics from tetragonal to cubic, although it did not induce the cationic ordering of Bi3+ and K+. It was also observed that the macroscopic domain structure disappeared after the slow cooling treatment. These observations demonstrated that the slow cooling treatment stabilized the R state in BKT to inhibit the spontaneous phase transition into the FE state. The possible reason for the stabilization of the R state in the slowly cooled BKT is discussed on the basis of the changes in cationic distribution and local compositional heterogeneity.

  6. Dielectric and Magnetic Properties of Ba(Fe1/2Ta1/2)O3-BiFeO3 Ceramics

    Science.gov (United States)

    Manotham, S.; Butnoi, P.; Jaita, P.; Pinitsoontorn, S.; Sweatman, D.; Eitssayeam, S.; Pengpat, K.; Rujijanagul, G.

    2016-11-01

    The properties of (1- x)Ba(Fe1/2Ta1/2)O3- xBiFeO3 [(1- x)BFT- xBFO] ( x = 0.0, 0.1, 0.3, 0.5) ceramics have been investigated. (1- x)BFT- xBFO powders were synthesized by a modified two-step calcination technique, and ceramics were fabricated by a conventional technique. X-ray diffraction (XRD) analysis revealed that the modified ceramics exhibited a mixture of BFT cubic phase and BFO rhombohedral phase. The peaks shift increased with increasing BFO content to a maximum value for the composition with x = 0.5. The overall shift of the XRD patterns indicated distortion of the unit cell, which may be due to ions from BFO entering the BFT lattice. BFO additive promoted grain growth, while the maximum density of the studied ceramics was observed for the x = 0.1 composition. The modified ceramics presented enhanced thermal and frequency stability of the dielectric constant. BFO additive also reduced the loss tangent for the system. Improvement of the magnetic behavior was observed after adding BFO. Furthermore, all the ceramics, including pure BFT (a nonmagnetic phase at room temperature), presented a magnetocapacitance effect, which can be related to magnetoresistance along with Maxwell-Wagner polarization effects.

  7. Reconciling Local Structure Disorder and the Relaxor State in (Bi1/2Na1/2)TiO3-BaTiO3

    Science.gov (United States)

    Groszewicz, Pedro B.; Gröting, Melanie; Breitzke, Hergen; Jo, Wook; Albe, Karsten; Buntkowsky, Gerd; Rödel, Jürgen

    2016-08-01

    Lead-based relaxor ferroelectrics are key functional materials indispensable for the production of multilayer ceramic capacitors and piezoelectric transducers. Currently there are strong efforts to develop novel environmentally benign lead-free relaxor materials. The structural origins of the relaxor state and the role of composition modifications in these lead-free materials are still not well understood. In the present contribution, the solid-solution (100-x)(Bi1/2Na1/2)TiO3-xBaTiO3 (BNT-xBT), a prototypic lead-free relaxor is studied by the combination of solid-state nuclear magnetic resonance (NMR) spectroscopy, dielectric measurements and ab-initio density functional theory (DFT). For the first time it is shown that the peculiar composition dependence of the EFG distribution width (ΔQISwidth) correlates strongly to the dispersion in dielectric permittivity, a fingerprint of the relaxor state. Significant disorder is found in the local structure of BNT-xBT, as indicated by the analysis of the electric field gradient (EFG) in 23Na 3QMAS NMR spectra. Aided by DFT calculations, this disorder is attributed to a continuous unimodal distribution of octahedral tilting. These results contrast strongly to the previously proposed coexistence of two octahedral tilt systems in BNT-xBT. Based on these results, we propose that considerable octahedral tilt disorder may be a general feature of these oxides and essential for their relaxor properties.

  8. Synthesis of Catechol by Dehydrogenation of 1,2-Cyclohexanediol%1,2-环己二醇催化脱氢制备邻苯二酚

    Institute of Scientific and Technical Information of China (English)

    谢英男; 章亚东; 蒋登高

    2005-01-01

    用均相沉淀法制备了Ni/硅藻土催化剂,用于催化1,2-环己二醇脱氢制备邻苯二酚,并用浸渍法添加Na+作为助剂,在微分反应器里考察了活性组分Ni含量、助催化剂Na含量、还原时间、反应温度、催化剂负荷等因素对反应的影响,确定了反应产物的气相色谱分析条件.当催化剂中w(Ni)=20%、w(Na)=4%、反应温度320 ℃、液时空速为9 h-1时,1,2-环己二醇转化率>95%,邻苯二酚收率>85%.

  9. Structural and impedance spectroscopy analysis of Ba(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Bhagat, S.; Prasad, K. [Materials Research Laboratory, University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812 007 (India)

    2010-05-15

    Lead-free perovskite Ba(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} (BFN) was prepared by conventional ceramic fabrication technique at 1200 C/5 h in air atmosphere. The crystal symmetry, space group, and unit cell dimensions were determined from the experimental results using FullProf software whereas crystallite size and lattice strain were estimated from Williamson-Hall approach. X-ray diffraction (XRD) analysis of the compound indicated the formation of a single-phase monoclinic structure with the space group P2/m. EDAX and SEM studies were carried out in order to evaluate the quality and purity of the compound. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were presented using the impedance data. Complex impedance analyses suggested the dielectric relaxation to be of non-Debye type. The correlated barrier hopping (CBH) model was employed to successfully explain the mechanism of charge transport in BFN. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  10. P2-type Na(x)[Fe(1/2)Mn(1/2)]O2 made from earth-abundant elements for rechargeable Na batteries.

    Science.gov (United States)

    Yabuuchi, Naoaki; Kajiyama, Masataka; Iwatate, Junichi; Nishikawa, Heisuke; Hitomi, Shuji; Okuyama, Ryoichi; Usui, Ryo; Yamada, Yasuhiro; Komaba, Shinichi

    2012-04-29

    Rechargeable lithium batteries have risen to prominence as key devices for green and sustainable energy development. Electric vehicles, which are not equipped with an internal combustion engine, have been launched in the market. Manganese- and iron-based positive-electrode materials, such as LiMn(2)O(4) and LiFePO(4), are used in large-scale batteries for electric vehicles. Manganese and iron are abundant elements in the Earth's crust, but lithium is not. In contrast to lithium, sodium is an attractive charge carrier on the basis of elemental abundance. Recently, some layered materials, where sodium can be electrochemically and reversibly extracted/inserted, have been reported. However, their reversible capacity is typically limited to 100 mAh g(-1). Herein, we report a new electrode material, P2-Na(2/3)[Fe(1/2)Mn(1/2)]O(2), that delivers 190 mAh g(-1) of reversible capacity in the sodium cells with the electrochemically active Fe(3+)/Fe(4+) redox. These results will contribute to the development of rechargeable batteries from the earth-abundant elements operable at room temperature.

  11. P2-type Nax[Fe1/2Mn1/2]O2 made from earth-abundant elements for rechargeable Na batteries

    Science.gov (United States)

    Yabuuchi, Naoaki; Kajiyama, Masataka; Iwatate, Junichi; Nishikawa, Heisuke; Hitomi, Shuji; Okuyama, Ryoichi; Usui, Ryo; Yamada, Yasuhiro; Komaba, Shinichi

    2012-06-01

    Rechargeable lithium batteries have risen to prominence as key devices for green and sustainable energy development. Electric vehicles, which are not equipped with an internal combustion engine, have been launched in the market. Manganese- and iron-based positive-electrode materials, such as LiMn2O4 and LiFePO4, are used in large-scale batteries for electric vehicles. Manganese and iron are abundant elements in the Earth’s crust, but lithium is not. In contrast to lithium, sodium is an attractive charge carrier on the basis of elemental abundance. Recently, some layered materials, where sodium can be electrochemically and reversibly extracted/inserted, have been reported. However, their reversible capacity is typically limited to 100 mAh g-1. Herein, we report a new electrode material, P2-Na2/3[Fe1/2Mn1/2]O2, that delivers 190 mAh g-1 of reversible capacity in the sodium cells with the electrochemically active Fe3+/Fe4+ redox. These results will contribute to the development of rechargeable batteries from the earth-abundant elements operable at room temperature.

  12. Electrical Properties of Textured (Bi1/2K1/2)TiO3-BaTiO3 Lead-Free Piezoelectric Ceramics

    Science.gov (United States)

    Nemoto, Masahiro; Hiruma, Yuji; Nagata, Hajime; Takenaka, Tadashi

    2009-07-01

    The electrical properties of (1-x)(Bi1/2K1/2)TiO3-xBaTiO3 (BKT-BT100x) ceramics prepared by an ordinary solid-state reaction and a reactive templated grain growth (RTGG) method using platelike Bi4Ti3O12 particles as a template were investigated. The degree of orientation, F, which was determined by the Lotgering method using an X-ray diffraction pattern, achieved ≈83% in the textured BKT-BT10 ceramic. A textured BKT-BT10 ceramic with a homogeneous microstructure was obtained after a long sintering time. The field-induced strains and piezoelectric properties of the BKT-BT10 ceramic were improved by improving grain orientation. In particular, the piezoelectric strain constant, d33, and the normalized strain, d33*, of the textured BKT-BT10 ceramic in the direction parallel (∥) to the tape stacking direction were 121 pC/N and 211 pm/V (at 80 kV/cm), respectively.

  13. Fabrication and Piezoelectric Properties of Grain-Oriented (Bi1/2K1/2)TiO3-BaTiO3 Ceramics

    Science.gov (United States)

    Nemoto, Masahiro; Hiruma, Yuji; Nagata, Hajime; Takenaka, Tadashi

    2008-05-01

    The piezoelectric properties of (1 - x)(Bi1/2K1/2)TiO3-xBaTiO3 (x = 0.1) [abbreviated as BKT-BT10] ceramics prepared by ordinary solid-state reaction and reactive templated grain growth (RTGG) using platelike Bi4Ti3O12 particles as a template were investigated. All samples showed a single-phase perovskite structure, and relative densities compared with theoretical densities were all higher than 95%. The degree of orientation F was determined by the Lotgering method using an X-ray diffraction (XRD) pattern. The F values of textured BKT-BT10 ceramics were relatively low at ˜35%. However, field-induced strains and piezoelectric properties of BKT-BT10 ceramics were improved by grain orientation. In particular, the piezoelectric strain constant d33 and the strain of textured BKT-BT10 ceramics in a direction parallel (∥) to the tape stacking direction were 84.5 pC/N and 168 pm/V (at 80 kV/cm), respectively.

  14. Determination of the hyperfine coupling constant of cesium 7S1/2 state

    CERN Document Server

    Yang, Guang; Yang, Baodong; Wang, Junmin

    2016-01-01

    We report the hyperfine splitting (HFS) measurement of cesium (Cs) 7S1/2 state by optical-optical double-resonance spectroscopy in the 6S1/2-6P3/2-7S1/2 (852 nm + 1470 nm) ladder-type system. The HFS frequency calibration is performed by employing a phase-type waveguide electro-optic modulator together with a stable confocal Fabry-Perot cavity. From the measured HFS between F"= 3 and F"= 4 manifolds of Cs 7S1/2 state [HFS = 2183.273(37) MHz], we have determined the magnetic dipole hyperfine coupling constant [A = 545.818(09) MHz], which is in good agreement with the previous work but much more accurate.

  15. Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways

    Directory of Open Access Journals (Sweden)

    Shian Huang

    2017-01-01

    Full Text Available This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC transdifferentiation into smooth muscle-like cells. TGF-β1-induced PAEC transdifferentiation models were applied to evaluate the pharmacological actions of quercetin. PAEC proliferation was detected with CCK8 method and BurdU immunocytochemistry. Meanwhile, the identification and transdifferentiation of PAECs were determined by FVIII immunofluorescence staining and α-SMA protein expression. The related mechanism was elucidated based on the levels of Akt and Erk1/2 signal pathways. As a result, quercetin effectively inhibited the TGF-β1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells. In conclusion, quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.

  16. Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols

    Directory of Open Access Journals (Sweden)

    Marcin Jasiński

    2012-04-01

    Full Text Available An approach to enantiopure hydroxylated 2H-1,2-oxazine derivatives is presented utilizing the [3 + 3] cyclisation of lithiated alkoxyallenes and an L-erythrose-derived N-glycosyl nitrone as precursors. This key step proceeded only with moderate diastereoselectivity, but allowed entry into both enantiomeric series of the resulting 3,6-dihydro-2H-1,2-oxazines. Their enol ether double bond was then subjected to a hydroboration followed by an oxidative work-up, and finally the auxiliary was removed. The described three-step procedure enabled the synthesis of enantiopure hydroxylated 1,2-oxazines. Typical examples were treated with samarium diiodide leading to enantiopure acyclic aminopolyols. We also report on our attempts to convert these compounds into enantiopure hydroxylated pyrrolidine derivatives.

  17. A new natural naphtho[1,2-b]furan from the leaves of Cassia fistula.

    Science.gov (United States)

    Wang, Li-Qin; Tang, Zheng-Rong; Mu, Wei-Hua; Kou, Jun-Feng; He, Dong-Yang

    2013-11-01

    A new naphtho[1,2-b]furan, 2,9-dihydroxy-7-methoxy-4-methylnaphtha[1,2-b]furan-3(2H)-one (1), along with 10 known compounds vanillic acid (2), naringenin (3), glyceryl-1-tetracosanoate (4), moracin J (5), 1,3,8-trihydroxyanthraquinone (6), esculetin (7), mauritianin (8), kaempferol 3-neohesperidoside (9), β-sitosterol (10), and β-daucosterol (11), was isolated from the leaves of Cassia fistula. The structure of the new compound was determined by NMR and X-ray analysis. Compounds 1, 3, 5-9 were isolated from this plant for the first time. The naphtha[1,2-b]furan was firstly isolated from the natural resources.

  18. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling.

    Science.gov (United States)

    Sukumaran, Bindu; Mastronunzio, Juliana E; Narasimhan, Sukanya; Fankhauser, Sarah; Uchil, Pradeep D; Levy, Roie; Graham, Morven; Colpitts, Tonya Michelle; Lesser, Cammie F; Fikrig, Erol

    2011-01-01

    Anaplasma phagocytophilum causes human granulocytic anaplasmosis, one of the most common tick-borne diseases in North America. This unusual obligate intracellular pathogen selectively persists within polymorphonuclear leucocytes. In this study, using the yeast surrogate model we identified an A. phagocytophilum virulence protein, AptA (A. phagocytophilum toxin A), that activates mammalian Erk1/2 mitogen-activated protein kinase. This activation is important for A. phagocytophilum survival within human neutrophils. AptA interacts with the intermediate filament protein vimentin, which is essential for A. phagocytophilum-induced Erk1/2 activation and infection. A. phagocytophilum infection reorganizes vimentin around the bacterial inclusion, thereby contributing to intracellular survival. These observations reveal a major role for the bacterial protein, AptA, and the host protein, vimentin, in the activation of Erk1/2 during A. phagocytophilum infection.

  19. Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway.

    Science.gov (United States)

    Jin, Enze; Han, Seongho; Son, Mina; Kim, Sung-Whan

    2016-01-01

    Cordyceps belongs to a genus of acormycete fungi and is known to exhibit various pharmacological effects. The aim of this study was to investigate the effect of Cordyceps species on the proliferation of vascular smooth muscle cells (VSMC) and their underlying molecular mechanism. A cell proliferation assay showed that Cordyceps bassiana ethanol extract (CBEE) significantly inhibited VSMC proliferation. In addition, neointimal formation was significantly reduced by treatment with CBEE in the carotid artery of balloon-injured rats. We also investigated the effects of CBEE on the extracellular signal-regulated kinase (ERK) signal pathway. Western blot analysis revealed increased ERK 1/2 phosphorylation in VSMCs treated with CBEE. Pretreatment with U0126 completely abrogated CBEE-induced ERK 1/2 phosphorylation. In conclusion, CBEE exhibited anti-proliferative properties that affected VSMCs through the ERK1/2 MAPK signaling pathway. Our data may elucidate the inhibitory mechanism of this natural product.

  20. The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism.

    Science.gov (United States)

    Fernandez, David I; Le Brun, Anton P; Whitwell, Thomas C; Sani, Marc-Antoine; James, Michael; Separovic, Frances

    2012-12-05

    The membrane interactions of the antimicrobial peptide aurein 1.2 were studied using a range of biophysical techniques to determine the location and the mechanism of action in DMPC (dimyristoylphosphatidylcholine) and DMPC/DMPG (dimyristoylphosphatidylglycerol) model membranes that mimic characteristics of eukaryotic and prokaryotic membranes, respectively. Neutron reflectometry and solid-state NMR revealed subtle changes in membrane structure caused by the peptide. Quartz crystal microbalance with dissipation, vesicle dye leakage and atomic force microscopy measurements were used to investigate the global mode of peptide interaction. Aurein 1.2 displayed an enhanced interaction with the anionic DMPC/DMPG membrane while exhibiting primarily a surface interaction with both types of model membranes, which led to bilayer disruption and membrane lysis. The antimicrobial peptide interaction is consistent with the carpet mechanism for aurein 1.2 with discrete structural changes depending on the type of phospholipid membrane.

  1. JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling

    DEFF Research Database (Denmark)

    Riveiro, Alba; Mariani, Luca; Malmberg, Kim Emily

    2017-01-01

    Components of the KDM7 family of histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated in cases of X-linked mental retardation. However, how PHF8 regulates neurodevelopmental processes and contributes to the disease is still largely unknown...... study highlights a novel function of jmjd-1.2 in axon guidance that might be relevant for the onset of X-linked mental retardation and provides compelling evidence of a conserved function of the Hedgehog pathway in C. elegans axon migration........ Here, we show that the catalytic activity of a PHF8 homolog in Caenorhabditis elegans, JMJD-1.2, is required non-cell-autonomously for proper axon guidance. Loss of JMJD-1.2 dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16, the overexpression of which is sufficient to induce...

  2. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.

    Science.gov (United States)

    Soeda, Yoshiyuki; Yoshikawa, Misato; Almeida, Osborne F X; Sumioka, Akio; Maeda, Sumihiro; Osada, Hiroyuki; Kondoh, Yasumitsu; Saito, Akiko; Miyasaka, Tomohiro; Kimura, Tetsuya; Suzuki, Masaaki; Koyama, Hiroko; Yoshiike, Yuji; Sugimoto, Hachiro; Ihara, Yasuo; Takashima, Akihiko

    2015-12-16

    Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the appearance of neurofibrillary tangles and contributes to neuronal loss. Here we show that tau oligomer formation can be inhibited by compounds whose chemical backbone includes 1,2-dihydroxybenzene. Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by hindering interactions between tau molecules. Further, we show that orally administered DL-isoproterenol, an adrenergic receptor agonist whose skeleton includes 1,2-dihydroxybenzene and which penetrates the brain, reduces the levels of detergent-insoluble tau, neuronal loss and reverses neurofibrillary tangle-associated brain dysfunction. Thus, compounds that target the cysteine residues of tau may prove useful in halting the progression of Alzheimer's disease and other tauopathies.

  3. Predicted Higgs-related spin 1/2 particles as a new dark matter candidate

    CERN Document Server

    Stenzel, Joshua; Lei, Minjie; Allen, Roland E

    2015-01-01

    The theory at arXiv:1101.0586 [hep-th] predicts new fundamental spin $1/2$ particles which can be produced in pairs through their couplings to vector bosons or fermions. The lowest-energy of these should have a mass $m_{1/2}$ comparable to the mass $m_h$ of the recently discovered Higgs boson, with $m_{1/2} = m_h$ in the simplest model. These particles should therefore be detectable in collider experiments, perhaps in Run 2 or 3 of the LHC. They cannot decay through any obvious mechanisms in standard physics, making them a new dark matter candidate. In the simplest model, annihilations would produce a well-defined signature with photons, positrons, and excess electrons at about 125 GeV, and the mass would also be well-defined for direct dark matter detection.

  4. A NEW POLYMER-BOUND 1,2-DIOL AS A PROTECTING AGENT FOR SYMMETRICAL DIALDEHYDE

    Institute of Scientific and Technical Information of China (English)

    REN Qisheng; HUANG Wenqiang; ZHAO Fengzhi; Ho Binglin

    1989-01-01

    A novel polymer- bound 1,2 - diol, 3 - polystyrylsulfonyl- 1,2 - propanediol (6) had ben prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3 - chloro - 1,2 - propanediol in the presence of a phase transfer catalyst ,n - tetrabutylammonium iodide. The capacity of resin 6 for terephthaldehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield:89%)and p-formyl -benzalcohol (yield:73 A % ), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites.

  5. BRCA 1/2-mutation related and sporadic breast and ovarian cancers: More alike than different

    Directory of Open Access Journals (Sweden)

    Melissa A. Burgess

    2014-02-01

    Full Text Available No longer is histology solely predictive of cancer treatment and outcome. There is an increasing influence of tumor genomic characteristics on therapeutic options. Both breast and ovarian cancers are at higher risk of development in patients with BRCA 1/2-germline mutations. Recent data from the Cancer Genome Atlas (TCGA and others have shown a number of genomic similarities between triple negative breast cancers and ovarian cancers. Recently, poly (ADP-ribose polymerase (PARP inhibitors have shown promising activity in hereditary BRCA 1/2-mutated and sporadic breast and ovarian cancers. In this review, we will summarize the current literature regarding the genomic and phenotypic similarities between BRCA 1/2-mutation related cancers, sporadic triple negative breast cancers, and sporadic ovarian cancers. We will also review phase I, II, and III data using PARP inhibitors for these malignancies and compare and contrast the results with respect to histology.

  6. The Breeding Bird Survey, 1967 and 1968

    Science.gov (United States)

    Robbins, C.S.; Van Velzen, W.T.

    1969-01-01

    In the Breeding Bird Survey of North America, cooperators ran 982 survey routes in 1967 and 1,174 in 1968. All States except Hawaii and all Canadian Provinces except Newfoundland were included. Roadside routes are selected at random within 1-degree blocks of latitude and longitude. Each 24 1/2-mile route, with 3-minute stops spaced half a mile apart, is driven by automobile. All birds heard or seen at the stops are recorded on special forms, and the data are transferred to magnetic tape for analysis. The average number of birds of each species per route is tabulated by State and Province, presenting for the first time a record of the comparative abundance of each species across the continent. The sample size is given for each species recorded. A sophisticated analysis program, here employed for the first time, is used to compute weighted mean values of the survey results for selected species at the State, stratum, regional, and continental level. The statistical significance of year-to-year changes at the 80, 90, 95, and 99 percent levels of probability are part of the computer output. An index for comparing populations of each species from year to year is established, with 1968 as the base year. Maps show the breeding range and comparative abundance of selected species.

  7. Seroprevalencia de HTLV-1/2 en donantes de sangre de la Provincia de Misiones Seroprevalence of HTLV-1/2 in blood donors from Misiones Province

    Directory of Open Access Journals (Sweden)

    Richard Malan

    2010-02-01

    Full Text Available El Virus Linfotrópico T Humano tipo 1 (HTLV-1, primer oncorretrovirus humano descubierto, es el causante etiológico de la leucemia de células T del adulto (ATL y de la mielopatía asociada al HTLV-1 o paraparesia espástica tropical (HAM/TSP. Es endémico en distintas partes del mundo, inclusive en el noroeste argentino, donde ambas enfermedades fueron detectadas. El HTLV-2, no tiene un rol etiológico definido, si bien ha sido asociado con síndromes neurológicos similares a la HAM/TSP. Ambos virus son endémicos en comunidades originarias del continente americano, tribus de Africa y poblaciones en riesgo. Ambos retrovirus se transmiten por vía sexual, parenteral y de madre a hijo. El objetivo de este trabajo fue determinar la seroprevalencia de HTLV-1/2 en una población de donantes de sangre de la provincia de Misiones. Se analizaron 6912 donaciones de sangre recibidas en el Banco de Sangre Central de la Provincia de Misiones durante 2008. La detección de anticuerpos se realizó por ELISA y aglutinación de partículas, y las muestras reactivas fueron confirmadas por Western Blot. Del total de muestras, 5 resultaron seropositivas con una prevalencia final de 0.00072. De ellas, una era HTLV, tres HTLV-1 y una HTLV-2 positiva. Los donantes positivos provenían de Posadas, Eldorado y Oberá, sin antecedentes de riesgo. Este estudio demuestra la presencia de HTLV-1/2 en donantes de sangre de Misiones, con cifras similares a las notificadas en donantes de sangre de zonas no endémicas.Human T-cell Lymphotropic viruses type 1 (HTLV-1, the first human oncoretrovirus to be discovered, is the etiologic agent of Adult T-cell Leukemia (ATL and HTLV-1 Associated Mielopathy or Tropical Spastic Paraparesis (HAM/TSP. It is endemic worldwide, including the North of Argentina where both associated diseases have also been detected. No etiologic role has been described for HTLV-2, although it has been associated with HAM/TSP-like neurologic syndromes. Both retroviruses are endemic in native populations of The Americas, Africa and at-risk populations. They are transmitted through sex contact, parenterally and from mother to child. The aim of this study was to estimate the seroprevalence of HTLV-1/2 in a blood donor population from Misiones province. A total of 6912 accepted blood donations in 2008 were analyzed. HTLV-1/2 screening was performed with ELISA and particle agglutination, and reactive samples were confirmed by Western Blot. From the total, 5 samples resulted seropositive with a final prevalence of 0.00072. Out of the 5 positive samples, one was an HTLV, three HTLV-1 and one HTLV-2. These blood donors were residents of Posadas, Eldorado and Oberá, with no risk antecedents. This study demonstrates the presence of HTLV-1/2 in a population of Misiones with a prevalence rate similar to those reported among blood donors from non-endemic areas.

  8. Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane.

    Science.gov (United States)

    Mena-Benitez, Gilda L; Gandia-Herrero, Fernando; Graham, Stuart; Larson, Tony R; McQueen-Mason, Simon J; French, Christopher E; Rylott, Elizabeth L; Bruce, Neil C

    2008-07-01

    Plants are increasingly being employed to clean up environmental pollutants such as heavy metals; however, a major limitation of phytoremediation is the inability of plants to mineralize most organic pollutants. A key component of organic pollutants is halogenated aliphatic compounds that include 1,2-dichloroethane (1,2-DCA). Although plants lack the enzymatic activity required to metabolize this compound, two bacterial enzymes, haloalkane dehalogenase (DhlA) and haloacid dehalogenase (DhlB) from the bacterium Xanthobacter autotrophicus GJ10, have the ability to dehalogenate a range of halogenated aliphatics, including 1,2-DCA. We have engineered the dhlA and dhlB genes into tobacco (Nicotiana tabacum 'Xanthi') plants and used 1,2-DCA as a model substrate to demonstrate the ability of the transgenic tobacco to remediate a range of halogenated, aliphatic hydrocarbons. DhlA converts 1,2-DCA to 2-chloroethanol, which is then metabolized to the phytotoxic 2-chloroacetaldehyde, then chloroacetic acid, by endogenous plant alcohol dehydrogenase and aldehyde dehydrogenase activities, respectively. Chloroacetic acid is dehalogenated by DhlB to produce the glyoxylate cycle intermediate glycolate. Plants expressing only DhlA produced phytotoxic levels of chlorinated intermediates and died, while plants expressing DhlA together with DhlB thrived at levels of 1,2-DCA that were toxic to DhlA-expressing plants. This represents a significant advance in the development of a low-cost phytoremediation approach toward the clean-up of halogenated organic pollutants from contaminated soil and groundwater.

  9. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas.

    Science.gov (United States)

    Kato, Yukinari

    2015-01-01

    Mutations of isocitrate dehydrogenase 1/2 (IDH1/2) have been reported in gliomas and other types of tumors, such as acute myeloid leukemias, cartilaginous tumors, intrahepatic cholangiocarcinomas, osteosarcomas, and giant cell tumors of bone. In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2. IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in the cytosol and mitochondria, respectively. In contrast, mutated IDH1/2 proteins possess a neomorphic enzymatic function that changes α-KG into the oncometabolite, R(-)-2-hydroxyglutarate, resulting in genomic hypermethylation, histone methylation, genetic instability, and malignant transformation. To date, several monoclonal antibodies (mAbs) specific for IDH1/2 mutations such as anti-IDH1-R132H mAbs (clone H09, clone IMab-1, and clone HMab-1) or an anti-IDH1-R132S mAb (clone SMab-1) have been established. Furthermore, one of multi-specific mAbs, MsMab-1, recognizes IDH1 mutants (R132H, R132S, R132G) and IDH2 mutants (R172S, R172G), which are observed in gliomas. Another mAb, MsMab-2, recognizes IDH1-R132L and IDH2-R172M. These IDH1/2 mutation-specific mAbs are useful for the immunohistochemical determination of IDH1/2 mutation-bearing gliomas.

  10. Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna.

    Science.gov (United States)

    Lee, Jiyun; Park, Nayeon; Kho, Younglim; Lee, Kiyoung; Ji, Kyunghee

    2017-01-01

    Parabens are used as antimicrobial preservatives in consumer products. Exposure to methylparaben (MP) has been associated with adverse health outcomes, therefore, an alternative compound, 1,2-hexanediol (1,2-H), has been applied for cosmetics. In the present study, the phototoxicity of MP and 1,2-H, as well as the toxic effect caused by chronic exposure, were investigated using Daphnia magna. The 48 h acute toxicity tests with D. magna were conducted under indoor or ultraviolet (UV) light irradiation conditions, i.e., exposure to 4 h/d sunlight. Changes in the transcription of genes related to oxidative stress were determined in D. magna juveniles, to investigate the underlying mechanism of phototoxicity. The 21 d chronic toxicity tests of MP and 1,2-H were performed under indoor light irradiation. Exposure to MP under environmental level of UV light was more detrimental to D. magna. Transcripts of catalase and glutathione-S-transferase genes in D. magna was significantly increased by co-exposure to MP and UV light. After 21 d of chronic exposure to MP and 1,2-H, the reproduction no-observed effect concentrations for D. magna were 1 and >10 mg/L, respectively. The present study showed that exposure to UV could magnify the toxicity of MP on daphnids. Although acute and chronic toxicities of 1,2-H were generally lower than those of MP, its effects on other aquatic organisms should not be ignored. Further studies are needed to identify other mechanisms of MP phototoxicity.

  11. Seroprevalence of HTLV1,2 Virus Among Injection Drug Addicts in Isfahan, 2007-2008

    Directory of Open Access Journals (Sweden)

    Sh Farzaneh

    2009-10-01

    Full Text Available Introduction: Human T-cell lymphotropic virus (HTLV, is a member of the retroviridae family. Infection with this virus leads to adult T-cell leukemia (ATL and tropical spastic paraparesis (TSP. HTLV is endemic in Japan, parts of central Africa, Caribbean basin and Iran (Mashhad. Transmission routes of HTLV are believed to be from mother to child, especially during breastfeeding, sexual contact, and through blood transfusion or needle sharing. Considering the risk of HTLV infection among injection drug addicts, the authors evaluated the seroprevalence of HTLV1,2 infection among injection drug addicts in Isfahan Methods: This cross sectional study included a total of 150 injection drug users who were recruited at the drug abuse treatment clinic and the infectious diseases department of Alzahra university Hospital. Participants were interviewed using a structured questionnaire. Epidemiologic data were recorded and their blood samples were tested for HBs Ag and antibodies against HTLV1,2, human immunodeficiency virus (HIV and hepatitis C (HCV by Elisa method . Results were analyzed by SPSS software version 13. Results: Seroprevalence of HTLV1,2, HBV(HBs Ag, HCV and HIV was 2.7%, 1.3% 23.3% and 2.7%, respectively. Some of the subjects were co infected with two viruses. One patient was infected with both HCV Ab and HBs Ag , while another was positive for HIV Ab plus HBs Ag . Three were co infected with HCV and HIV. Among those with HTLV1,2, only one was HCV Ab positive. Only in one person with HTLV1,2 Ab had a positive history of blood transfusion. Conclusion: This study shows that this virus is present in injection drug users community of Isfahan and can be a potential source for transmission. But proposal of screening of HTLV1,2 among injection drug users in Isfahan requires further investigations.

  12. Isolation and characterization of tetrachloroethylene- and cis-1,2-dichloroethylene-dechlorinating propionibacteria.

    Science.gov (United States)

    Chang, Young-Cheol; Ikeutsu, Kaori; Toyama, Tadashi; Choi, Dubok; Kikuchi, Shintaro

    2011-10-01

    Two rapidly growing propionibacteria that could reductively dechlorinate tetrachloroethylene (PCE) and cis-1,2-dichloroethylene (cis-DCE) to ethylene were isolated from environmental sediments. Metabolic characterization and partial sequence analysis of their 16S rRNA genes showed that the new isolates, designated as strains Propionibacterium sp. HK-1 and Propionibacterium sp. HK-3, did not match any known PCE- or cis-DCE-degrading bacteria. Both strains dechlorinated relatively high concentrations of PCE (0.3 mM) and cis-DCE (0.52 mM) under anaerobic conditions without accumulating toxic intermediates during incubation. Cell-free extracts of both strains catalyzed PCE and cis-DCE dechlorination; degradation was accelerated by the addition of various electron donors. PCE dehalogenase from strain HK-1 was mediated by a corrinoid protein, since the dehalogenase was inactivated by propyl iodide only after reduction by titanium citrate. The amounts of chloride ions (0.094 and 0.103 mM) released after PCE (0.026 mM) and cis-DCE (0.05 mM) dehalogenation using the cell-free enzyme extracts of both strains, HK-1 and HK-3, were stoichiometrically similar (91 and 100%), indicating that PCE and cis-DCE were fully dechlorinated. Radiotracer studies with [1,2-¹⁴C] PCE and [1,2-¹⁴C] cis-DCE indicated that ethylene was the terminal product; partial conversion to ethylene was observed. Various chlorinated aliphatic compounds (PCE, trichloroethylene, cis-DCE, trans-1,2-dichloroethylene, 1,1-dichloroethylene, 1,1-dichloroethane, 1,2-dichloroethane, 1,2-dichloropropane, 1,1,2-trichloroethane, and vinyl chloride) were degraded by cell-free extracts of strain HK-1.

  13. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium.

    Science.gov (United States)

    Liu, Zhiwei; Yu, Xinyuan; Shaikh, Zahir A

    2008-05-01

    Cadmium (Cd), an endocrine disruptor, can induce a variety of signaling events including the activation of ERK1/2 and AKT. In this study, the involvement of estrogen receptors (ER) in these events was evaluated in three human breast cancer cell lines, MCF-7, MDA-MB-231, and SK-BR-3. The Cd-induced signal activation patterns in the three cell lines mimicked those exhibited in response to 17 beta-estradiol. Specifically, treatment of MCF-7 cells, that express ER alpha, ER beta and GPR30, to 0.5-10 microM Cd for only 2.5 min resulted in transient phosphorylation of ERK1/2. Cd also triggered a gradual increase and sustained activation of AKT during the 60 min treatment period. In SK-BR-3 cells, that express only GPR30, Cd also caused a transient activation of ERK1/2, but not of AKT. In contrast, in MDA-MB-231 cells, that express only ER beta, Cd was unable to cause rapid activation of either ERK1/2 or AKT. A transient phosphorylation of ER alpha was also observed within 2.5 min of Cd exposure in the MCF-7 cells. While the estrogen receptor antagonist, ICI 182,780, did not prevent the effect of Cd on these signals, specific siRNA against hER alpha significantly reduced Cd-induced activation of ERK1/2 and completely blocked the activation of AKT. It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and AKT and that these signaling events are mediated by possible interaction with membrane ER alpha and GPR30, but not ER beta.

  14. Immigrants in the one percent: The national origin of top wealth owners

    Science.gov (United States)

    Keister, Lisa A.; Aronson, Brian

    2017-01-01

    Background Economic inequality in the United States is extreme, but little is known about the national origin of affluent households. Households in the top one percent by total wealth own vastly disproportionate quantities of household assets and have correspondingly high levels of economic, social, and political influence. The overrepresentation of white natives (i.e., those born in the U.S.) among high-wealth households is well-documented, but changing migration dynamics suggest that a growing portion of top households may be immigrants. Methods Because no single survey dataset contains top wealth holders and data about country of origin, this paper uses two publicly-available data sets: the Survey of Consumer Finances (SCF) and the Survey of Income and Program Participation (SIPP). Multiple imputation is used to impute country of birth from the SIPP into the SCF. Descriptive statistics are used to demonstrate reliability of the method, to estimate the prevalence of immigrants among top wealth holders, and to document patterns of asset ownership among affluent immigrants. Results Significant numbers of top wealth holders who are usually classified as white natives may be immigrants. Many top wealth holders appear to be European and Canadian immigrants, and increasing numbers of top wealth holders are likely from Asia and Latin America as well. Results suggest that of those in the top one percent of wealth holders, approximately 3% are European and Canadian immigrants, .5% are from Mexico or Cuban, and 1.7% are from Asia (especially Hong Kong, Taiwan, Mainland China, and India). Ownership of key assets varies considerably across affluent immigrant groups. Conclusion Although the percentage of top wealth holders who are immigrants is relatively small, these percentages represent large numbers of households with considerable resources and corresponding social and political influence. Evidence that the propensity to allocate wealth to real and financial assets varies

  15. SVR-D1.2: A Prediction Model for Population Occurrence of Paddy Stem Borer

    Directory of Open Access Journals (Sweden)

    Lichuan Gu

    2012-08-01

    Full Text Available In this study, we analyse the SVR-based prediction method for selecting the optimal model framework based on kernel matrix. Moreover, SVR-D1.2 is proposed with the help of the kernel matrix’s symmetry and positive definition and kernel alignment. Test results show that there exactly exists the non-line relation between the insect population occurrence and the meteorological factors and the new prediction model, SVR-D1.2, improved prediction accuracy compared with other methods.

  16. The Role of ERK1/2 in the Development of Diabetic Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Zheng Xu

    2016-12-01

    Full Text Available Diabetes mellitus is a chronic metabolic condition that affects carbohydrate, lipid and protein metabolism and may impair numerous organs and functions of the organism. Cardiac dysfunction afflicts many patients who experience the oxidative stress of the heart. Diabetic cardiomyopathy (DCM is one of the major complications that accounts for more than half of diabetes-related morbidity and mortality cases. Chronic hyperglycemia and hyperlipidemia from diabetes mellitus cause cardiac oxidative stress, endothelial dysfunction, impaired cellular calcium handling, mitochondrial dysfunction, metabolic disturbances, and remodeling of the extracellular matrix, which ultimately lead to DCM. Although many studies have explored the mechanisms leading to DCM, the pathophysiology of DCM has not yet been fully clarified. In fact, as a potential mechanism, the associations between DCM development and mitogen-activated protein kinase (MAPK activation have been the subjects of tremendous interest. Nonetheless, much remains to be investigated, such as tissue- and cell-specific processes of selection of MAPK activation between pro-apoptotic vs. pro-survival fate, as well as their relation with the pathogenesis of diabetes and associated complications. In general, it turns out that MAPK signaling pathways, such as extracellular signal-regulated kinase 1/2 (ERK1/2, c-Jun N-terminal protein kinase (JNK and p38 MAP kinase, are demonstrated to be actively involved in myocardial dysfunction, hypertrophy, fibrosis and heart failure. As one of MAPK family members, the activation of ERK1/2 has also been known to be involved in cardiac hypertrophy and dysfunction. However, many recent studies have demonstrated that ERK1/2 signaling activation also plays a crucial role in FGF21 signaling and exerts a protective environment of glucose and lipid metabolism, therefore preventing abnormal healing and cardiac dysfunction. The duration, extent, and subcellular compartment of ERK1/2 activation are vital to differential biological effects of ERK1/2. Moreover, many intracellular events, including mitochondrial signaling and protein kinases, manipulate signaling upstream and downstream of MAPK, to influence myocardial survival or death. In this review, we will summarize the roles of ERK1/2 pathways in DCM development by the evidence from current studies and will present novel opinions on “differential influence of ERK1/2 action in cardiac dysfunction, and protection against myocardial ischemia-reperfusion injury”.

  17. Analysis of surface error correction capability of 1.2m active support system

    Science.gov (United States)

    Han, Yu; Fan, Bin; Li, Chaoqiang; Liu, Haitao

    2016-10-01

    The surface error correction ability is one of the important indicators to measure the performance of the active support system. In this paper, the correction force algorithm for the active support system of 1.2m thin meniscus mirror is introduced. Based on this algorithm, a simulation analysis is made. The simulation results show that the 1.2m active support system has excellent correction ability for Zernike polynomials term 4, 5, 6, 10 and 11, and has a good effect on the Zernike polynomials term 7 and 8.

  18. Reactive modelling of 1,2-DCA and DOC near the shoreline.

    Science.gov (United States)

    Colombani, N; Pantano, A; Mastrocicco, M; Petitta, M

    2014-11-15

    1,2-Dichloroethane (1,2-DCA) was found to be the most abundant compound among chlorinated hydrocarbons detected in a petrochemical plant in southern Italy. This site is located near the coastline, and it is set above an unconfined coastal aquifer, where seawater intrusion is present. The presence of organic and inorganic contaminants at this site has required the implementation of remediation strategies, consisting of pumping wells (hydraulic barrier) and a horizontal flow barrier. The purpose of this work was to assess the influence of salt water intrusion on the degradation rate of 1,2-DCA. This was done on a three-dimensional domain relative to a limited portion of a well characterized field site, accounting for density-dependent flow and reactive transport modelling of 1,2-DCA and Dissolved Organic Carbon (DOC). The modelling procedure was performed employing SEAWAT-4.0 and PHT3D, to reproduce the complex three-dimensional flow and transport domain. In order to determine the fate of 1,2-DCA, detailed field investigations provided intensive depth profile information. Different, kinetically controlled degradation rates were simulated to explain the observed, selective degradation of pollutants in groundwater. Calibration of the model was accomplished by comparison with the two different sets of measurements obtained from the MLS devices and from pumping wells. With the calibrated model, it was possible to distinguish between dispersive non-reactive processes and bacterially mediated reactions. In the non-reactive model, 1,2-DCA sorption was simulated using linear sorption coefficient determined with field data and 1,2-DCA degradation was simulated using a first order decay coefficient using literature data as initial guess. Finally, on the reactive transport model, where a two-step approach with partial equilibrium approach was implemented, the effects of neglecting the cation exchange capacity, omitting density-dependent flow, and refining the vertical discretization of the model were investigated. Comparison of results from various scenarios shows that geochemical changes in inorganic constituents can be used to improve the site's conceptual model, and establishes that natural degradation processes can be suitable for 1,2-DCA as a remediation option.

  19. OSp(1,2)-covariant Lagrangian quantization of irreducible massive gauge theories

    CERN Document Server

    Geyer, B; Mülsch, D

    1997-01-01

    The OSp(1,2)-covariant Lagrangian quantization of general gauge theories is formulated which applies also to massive gauge fields. The formalism generalizes the Sp(2)-covariant BLT approach and guarantees symplectic invariance of the quantized action. The dependence of the generating functional of Green's functions on the choice of gauge in the massive case disappears in the limit m = 0. Ward identities related to OSp(1,2) symmetry are derived. Massive gauge theories with closed algebra are studied as an example.

  20. osp(1,2)-covariant Lagrangian quantization of reducible massive gauge theories

    CERN Document Server

    Geyer, B; Mülsch, D

    1999-01-01

    The osp(1,2)-covariant Lagrangian quantization of irreducible gauge theories [hep-th/9712204] is generalized to L-stage reducible theories. The dependence of the generating functional of Green's functions on the choice of gauge in the massive case is dicussed and Ward identities related to osp(1,2) symmetry are given. Massive first stage theories with closed gauge algebra are studied in detail. The generalization of the Chapline-Manton model and topological Yang-Mills theory to the case of massive fields is consedered as examples.

  1. Crystal structure of racemic cis-2-amino-1,2-diphenylethanol (ADE

    Directory of Open Access Journals (Sweden)

    Isao Fujii

    2015-12-01

    Full Text Available In the title racemic compound, C14H15NO, the hydroxy and amino groups form a bent tweezer-like motif towards the phenyl groups. In the crystal, enantiomers aggregate with each other and are linked by O—H...N hydrogen bonds, forming chiral 21-helical columnar structures from C(5 chains along the b-axis direction. Left- and right-handed 21 helices are formed from (1S,2R-2-amino-1,2-diphenylethanol and (1R,2S-2-amino-1,2-diphenylethanol, respectively.

  2. 3-[Chloro-(phen-yl)meth-yl]-6-methyl-1,2-benzoxazole.

    Science.gov (United States)

    Kayalvizhi, M; Vasuki, G; Ramamurthi, K; Veerareddy, A; Laxminarasimha, G

    2011-11-01

    The title compound, C(15)H(12)ClNO, is a functionalized 1,2-benzoxazole with a chloro-(phen-yl)methyl substituent. The mol-ecule is V-shaped, the dihedral angle between the mean plane of the 1,2-benzoxazole system [maximum deviation = 0.023 (3) Å for the N atom] and the phenyl ring being 70.33 (14)°. There are no hydrogen-bonding inter-actions in the crystal structure, which is stabilized by van der Waals inter-actions only.

  3. A pruning algorithm with L1/2 regularizer for extreme learning machine

    Institute of Scientific and Technical Information of China (English)

    Ye-tian FAN; Wei WU; Wen-yu YANG; Qin-wei FAN; Jian WANG

    2014-01-01

    Compared with traditional learning methods such as the back propagation (BP) method, extreme learning machine provides much faster learning speed and needs less human intervention, and thus has been widely used. In this paper we combine the L1/2 regularization method with extreme learning machine to prune extreme learning machine. A variable learning coefficient is employed to prevent too large a learning increment. A numerical experiment demonstrates that a network pruned by L1/2 regularization has fewer hidden nodes but provides better performance than both the original network and the network pruned by L2 regularization.

  4. Effects of processing conditions on microstructural and dielectrical properties of K{sub 1}/2Na{sub 1}/2NbO{sub 3} ceramics; Influencia de las condiciones de procesamiento sobre las propiedades dielectricas y microestructurales de ceramicos de K{sub 1}/2Na{sub 1}/2NbO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Ramajo, L.; Reboredo, M. M.; Castro, M. S.

    2011-07-01

    The objective of this work was to analyze different processing condition of Na{sub 1}/2K{sub 1}/2NbO{sub 3} (KNN) in order to obtain a material with good properties and without secondary phases. Solid state reaction method was used and the influence of milling time, calcination temperature and time, and sintering temperature was analyzed. It was found that sintering temperatures were limited by the component decomposition. Also, it was observed that samples sintered at 1125 degree centigrade showed the highest density and permittivity with a homogeneous structure. In general, samples calcined at higher temperatures and times showed the best properties. (Author) 26 refs.

  5. A new model to estimate significant wave heights with ERS-1/2 scatterometer data

    Institute of Scientific and Technical Information of China (English)

    GUO Jie; HE Yijun; William Perrie; SHEN Hui; CHU Xiaoqing

    2009-01-01

    A new model is proposed to estimate the significant wave heights with ERS-1/2 scatterometer data. The results show that the relationship between wave parameters and radar backscattering cross section is similar to that between wind and the radar backscattering cross section. Therefore, the relationship between significant wave height and the radar backscattering cross section is established with a neural network algorithm, which is, if the average wave period is ≤7s, the root mean square of significant wave height retrieved from ERS-1/2 data is 0.51 m, or 0.72 m if it is >7s otherwise.

  6. Near Zero Emissions at 50 Percent Thermal Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-12-31

    Detroit Diesel Corporation (DDC) has successfully completed a 10 year DOE sponsored heavy-duty truck engine program, hereafter referred to as the NZ-50 program. This program was split into two major phases. The first phase was called Near-Zero Emission at 50 Percent Thermal Efficiency, and was completed in 2007. The second phase was initiated in 2006, and this phase was named Advancements in Engine Combustion Systems to Enable High-Efficiency Clean Combustion for Heavy-Duty Engines. This phase was completed in September, 2010. The key objectives of the NZ-50 program for this first phase were to: Quantify thermal efficiency degradation associated with reduction of engine-out NOx emissions to the 2007 regulated level of ~1.1 g/hp-hr. Implement an integrated analytical/experimental development plan for improving subsystem and component capabilities in support of emerging engine technologies for emissions and thermal efficiency goals of the program. Test prototype subsystem hardware featuring technology enhancements and demonstrate effective application on a multi-cylinder, production feasible heavy-duty engine test-bed. Optimize subsystem components and engine controls (calibration) to demonstrate thermal efficiency that is in compliance with the DOE 2005 Joule milestone, meaning greater than 45% thermal efficiency at 2007 emission levels. Develop technology roadmap for meeting emission regulations of 2010 and beyond while mitigating the associated degradation in engine fuel consumption. Ultimately, develop technical prime-path for meeting the overall goal of the NZ-50 program, i.e., 50% thermal efficiency at 2010 regulated emissions. These objectives were successfully met during the course of the NZ-50 program. The most noteworthy achievements in this program are summarized as follows: Demonstrated technologies through advanced integrated experiments and analysis to achieve the technical objectives of the NZ-50 program with 50.2% equivalent thermal efficiency under

  7. MEASUREMENT OF HEMOGLOBIN AND ALBUMIN ADDUCTS OF NAPHTHALENE-1,2-OXIDE, 1,2-NAPHTHOQUINONE AND 1,4-NAPHTHOQUINONE AFTER ADMINISTRATION OF NAPHTHALENE TO F344 RATS

    Science.gov (United States)

    Naphthalene-1,2-oxide (NPO), 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) are the major metabolites of naphthalene that are thought to be responsible for the cytotoxicity and genotoxicity of this chemical. We measured cysteinyl adducts of these metabolites in ...

  8. μ-1,2-Bis(diphenylphosphinoethane-κ2P:P′-bis{[1,2-bis(diphenylphosphinoethane-κ2P,P′]bromidocopper(I} acetone disolvate

    Directory of Open Access Journals (Sweden)

    Wen-Juan Shi

    2008-10-01

    Full Text Available In the crystal structure of the title compound, [Cu2Br2(dppe3]·2CH3COCH3 [dppe is 1,2-bis(diphenylphosphinoethane, C26H24P2], the two Cu centers are bridged by a dppe ligand and each metal center carries one chelating dppe unit, with the fourth coordination site available for the Br− anion. The molecule is centrosymmetric, with the center of symmetry located between the methylene C atoms of the bridging dppe ligand. The crystal structure is stabilized by intramolecular C—H...Br hydrogen bonds and intermolecular π–π interactions, with a centroid-to-centroid distance of 3.2055 (1 Å.

  9. [μ-1,2-Bis(diphenylphosphinoethane-κ2P:P′]bis{[1,2-bis(diphenylphosphinoethane-κ2P,P′]cyanidocopper(I} methanol disolvate

    Directory of Open Access Journals (Sweden)

    Rong Wang

    2010-08-01

    Full Text Available The title centrosymmetric complex, [Cu2(CN2(C26H24P23]·2CH3OH, consists of two five-membered [Cu(dppeCN] rings [dppe is 1,2-bis(diphenylphosphinoethane] bridged by one μ2-dppe ligand, and two methanol solvent molecules. The angles around the central metal atom indicate that each CuI atom is located in the center of a distorted tetrahedron. The coordination sphere of each CuI atom is formed by three P atoms from two dppe ligands, and one C atom from the cyanide ligand. The crystal structure is stabilized by O—H...N hydrogen bonds, which are formed by the O—H donor group from methanol and the N-atom acceptor from a cyanide ligand.

  10. Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives

    Institute of Scientific and Technical Information of China (English)

    Jin Pei Zhou; Yi Wei Ding; Hui Bin Zhang; Lian Xu; Yue Dai

    2008-01-01

    A series of imidazo [1,2-a] pyrimidine derivatives substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized in order to improve their anti-inflammatory activities. Biological tests suggested that these compounds have antiinflammatory activities with COX-2 selectivity to some extent.

  11. Critical behavior of the spin-$1/2$ Baxter-Wu model: Entropic sampling simulations

    CERN Document Server

    Jorge, L N; Caparica, A A

    2015-01-01

    In this work we use a refined entropic sampling technique based on the Wang-Landau method to study the spin-$1/2$ Baxter-Wu model. The static critical exponents were determined as $\\alpha=0.6545(68)$, $\\beta=0.0818(30)$, $\\gamma=1.18193(77)$, and $\

  12. One-pot synthesis of acenaphtho[1,2-b]furan derivatives

    Institute of Scientific and Technical Information of China (English)

    Mohammad Taghi Goldani; Reza Sandaroos; Saman Damavandi

    2012-01-01

    New 9-(alkyl or aryl)acenaphtho[ 1,2-b]furan-8-(alky or aryl)amine compounds has herein been reported by one-pot reaction of (acenaphthylen-l-yloxy)trimethylsilane,alkyl and aryl aldehydes,and aryl and alky isocyanides in refluxing DMF.

  13. Why the Faulhaber Polynomials Are Sums of Even or Odd Powers of (n + 1/2)

    Science.gov (United States)

    Hersh, Reuben

    2012-01-01

    By extending Faulhaber's polynomial to negative values of n, the sum of the p'th powers of the first n integers is seen to be an even or odd polynomial in (n + 1/2) and therefore expressible in terms of the sum of the first n integers.

  14. Photoelectron spectroscopy investigations of pyrrolo[1,2-a][1,10]phenanthroline derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Prelipceanu, M.; Prelipceanu, O.S. [University of Applied Sciences Wildau, Department of Engineering, Institute of Photonics and Physics Technologies, Friedrich-Engels Street 63, 15745 Wildau (Germany); Leontie, L. [Faculty of Physics, ' Al.I. Cuza' University, 11 Carol I Boulevard, 700506 Iasi (Romania)], E-mail: lleontie@uaic.ro; Danac, R. [Faculty of Chemistry, ' Al.I. Cuza' University, 11 Carol I Boulevard, 700506 Iasi (Romania)

    2007-08-20

    Thin films of new pyrrolo[1,2-a][1,10]phenanthroline derivatives have been investigated by ultraviolet photoelectron spectroscopy, with a view of future applications in optoelectronic devices. The electronic band structure of investigated compounds (for electron energies {<=}25 eV) is to a great extent determined by substituent (R = NO{sub 2}, Cl) induced transformations of molecular orbitals.

  15. Dichloridobis[1-(2-methylbenzimidazol-1-ylmethyl-κN3benzotriazole]mercury(II

    Directory of Open Access Journals (Sweden)

    Jie Wu

    2009-07-01

    Full Text Available In the title compound, [HgCl2(C15H13N52], the HgII atom is located on a twofold rotation axis and resides in a distorted tetrahedral coordination environment composed of two Cl atoms and two N atoms from two 1-(2-methylbenzimidazol-1-ylmethylbenzotriazole ligands.

  16. Numerical study of the spin-flop transition in anisotropic spin-1/2 antiferromagnets

    NARCIS (Netherlands)

    Yunoki, S

    2002-01-01

    Magnetization processes of the spin-1/2 antiferromagnetic XXZ model in two and three spatial dimensions are studied using a quantum Monte Carlo method based on stochastic series expansions. A recently developed operator-loop algorithm enables us to show clear evidence of a first-order phase transiti

  17. Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?

    NARCIS (Netherlands)

    Tilborg, T.C. van; Broekmans, F.J.; Pijpe, A.; Schrijver, L.H.; Mooij, T.M.; Oosterwijk, J.C; Verhoef, S.; Gomez Garcia, E.B.; Zelst-Stams, W.A.G. van; Adank, M.A.; Asperen, C.J. van; Doorn, H.C. van; Os, T.A. van; Bos, A.M.; Rookus, M.A.; Ausems, M.G.

    2016-01-01

    OBJECTIVE: It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature. METHOD

  18. Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?

    NARCIS (Netherlands)

    van Tilborg, Theodora C.; Broekmans, Frank J.; Pijpe, Anouk; Schrijver, Lieske H.; Mooij, Thea M.; Oosterwijk, Jan C.; Verhoef, Senno; Garcia, Encarna B. Gomez; van Zelst-Stams, Wendy A.; Adank, Muriel A.; van Asperen, Christi J.; van Doorn, Helena C.; van Os, Theo A.; Bos, Anna M.; Rookus, Matti A.; Ausems, Margreet G.

    2016-01-01

    Objective: It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature. Method

  19. Efficient hydrogenation of biomass-derived cyclic di-esters to 1,2-diols.

    Science.gov (United States)

    Balaraman, Ekambaram; Fogler, Eran; Milstein, David

    2012-01-28

    The unprecedented homogeneous hydrogenation of cyclic di-esters, in particular biomass-derived glycolide and lactide, to the corresponding 1,2-diols is catalyzed by Ru(II) PNN (1) and Ru(II) CNN (2) pincer complexes under mild hydrogen pressure and (in the case of 1) neutral conditions. No racemization was observed when a chiral di-ester was used.

  20. Extended quantum critical phase in a magnetized spin-1/2 antiferromagnetic chain

    DEFF Research Database (Denmark)

    Stone, M.B.; Reich, D.H.; Broholm, C.

    2003-01-01

    Measurements are reported of the magnetic field dependence of excitations in the quantum critical state of the spin S=1/2 linear chain Heisenberg antiferromagnet copper pyrazine dinitrate (CuPzN). The complete spectrum was measured at k(B)T/Jless than or equal to0.025 for H=0 and H=8.7 T, where...

  1. Most spin-1/2 transition-metal ions do have single ion anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jia; Whangbo, Myung-Hwan, E-mail: hxiang@fudan.edu.cn, E-mail: mike-whangbo@ncsu.edu [Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 (United States); Koo, Hyun-Joo [Department of Chemistry and Research Institute for Basic Sciences, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Xiang, Hongjun, E-mail: hxiang@fudan.edu.cn, E-mail: mike-whangbo@ncsu.edu [Key Laboratory of Computational Physical Sciences (Ministry of Education), State Key Laboratory of Surface Physics, and Department of Physics, Fudan University, Shanghai 200433 (China); Kremer, Reinhard K. [Max-Planck-Institut für Festkörperforschung, Heisenbergstrasse 1, D-70569 Stuttgart (Germany)

    2014-09-28

    The cause for the preferred spin orientation in magnetic systems containing spin-1/2 transition-metal ions was explored by studying the origin of the easy-plane anisotropy of the spin-1/2 Cu{sup 2+} ions in CuCl{sub 2}·2H{sub 2}O, LiCuVO{sub 4}, CuCl{sub 2}, and CuBr{sub 2} on the basis of density functional theory and magnetic dipole-dipole energy calculations as well as a perturbation theory treatment of the spin-orbit coupling. We find that the spin orientation observed for these spin-1/2 ions is not caused by their anisotropic spin exchange interactions, nor by their magnetic dipole-dipole interactions, but by the spin-orbit coupling associated with their crystal-field split d-states. Our study also predicts in-plane anisotropy for the Cu{sup 2+} ions of Bi{sub 2}CuO{sub 4} and Li{sub 2}CuO{sub 2}. The results of our investigations dispel the mistaken belief that magnetic systems with spin-1/2 ions have no magnetic anisotropy induced by spin-orbit coupling.

  2. The non-intuitive 1/2 Thomas factor: a heuristic argument with classical electromagnetism

    Energy Technology Data Exchange (ETDEWEB)

    Chrysos, M [Laboratoire des Proprietes Optiques des Materiaux et Applications, UMR CNRS 6136, Universite d' Angers, 2 boulevard Lavoisier, 49045 Angers, (France)

    2006-01-01

    We present a heuristic argument to deduce the non-intuitive 1/2 Thomas factor for an atomic electron revolving in its orbit about the nucleus. The argument, which is simple, pedagogical and accessible to physics beginners, uses elementary notions of classical electromagnetism rather than the advanced relativity concepts which are needed in any standard textbook derivation.

  3. Production of 1,2-propanediol from glycerol in Saccharomyces cerevisiae.

    Science.gov (United States)

    Jung, Joon-Young; Yun, Hyun Shik; Lee, Jinwon; Oh, Min-Kyu

    2011-08-01

    Glycerol has become an attractive carbon source in the biotechnology industry owing to its low price and reduced state. However, glycerol is rarely used as a carbon source in Saccharomyces cerevisiae because of its low utilization rate. In this study, we used glycerol as a main carbon source in S. cerevisiae to produce 1,2-propanediol. Metabolically engineered S. cerevisiae strains with overexpression of glycerol dissimilation pathway genes, including glycerol kinase (GUT1), glycerol 3-phosphate dehydrogenase (GUT2), glycerol dehydrogenase (gdh), and a glycerol transporter gene (GUP1), showed increased glycerol utilization and growth rate. More significant improvement of glycerol utilization and growth rate was accomplished by introducing 1,2-propanediol pathway genes, mgs (methylglyoxal synthase) and gldA (glycerol dehydrogenase) from Escherichia coli. By engineering both glycerol dissimilation and 1,2-propanediol pathways, the glycerol utilization and growth rate were improved 141% and 77%, respectively, and a 2.19 g 1,2- propanediol/l titer was achieved in 1% (v/v) glycerolcontaining YEPD medium in engineered S. cerevisiae.

  4. Diverse Reductive Dehalogenases Are Associated with Clostridiales-Enriched Microcosms Dechlorinating 1,2-Dichloroethane

    KAUST Repository

    Merlino, Giuseppe

    2015-03-06

    The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial community developed in anaerobic microcosms after biostimulation with the electron donor lactate of groundwater polluted with 1,2-dichloroethane (1,2-DCA). Through a multilevel analysis, we have assessed (i) the structural analysis of the bacterial community; (ii) the identification of putative dehalorespiring bacteria; (iii) the characterization of functional genes encoding for putative 1,2-DCA reductive dehalogenases (RDs). Following the biostimulation treatment, the structure of the bacterial community underwent a notable change of the main phylotypes, with the enrichment of representatives of the order Clostridiales . Through PCR targeting conserved regions within known RD genes, four novel variants of RDs previously associated with the reductive dechlorination of 1,2-DCA were identified in the metagenome of the Clostridiales-dominated bacterial community.

  5. Chiral gas chromatography for the determination of 1,2-O-isopropylidene-sn-glycerol stereoisomers

    NARCIS (Netherlands)

    Dröge, M.J; Bos, R.; Woerdenbag, H.J.; Quax, Wim; Droge, MJ

    2003-01-01

    A stereospecific gas chromatography (GC) method using a (6-O-tButyldimethylsilyl-2,3-di-O-methyl)-beta-cyclodextrin as the chiral stationary phase has been developed and validated for the determination of the enantiomers of 1,2-O-isopropylidene-sn-glycerol (IPG), an important chiral synthon, in kine

  6. The L(1/2) regularization approach for survival analysis in the accelerated failure time model.

    Science.gov (United States)

    Chai, Hua; Liang, Yong; Liu, Xiao-Ying

    2015-09-01

    The analysis of high-dimensional and low-sample size microarray data for survival analysis of cancer patients is an important problem. It is a huge challenge to select the significantly relevant bio-marks from microarray gene expression datasets, in which the number of genes is far more than the size of samples. In this article, we develop a robust prediction approach for survival time of patient by a L(1/2) regularization estimator with the accelerated failure time (AFT) model. The L(1/2) regularization could be seen as a typical delegate of L(q)(0regularization methods and it has shown many attractive features. In order to optimize the problem of the relevant gene selection in high-dimensional biological data, we implemented the L(1/2) regularized AFT model by the coordinate descent algorithm with a renewed half thresholding operator. The results of the simulation experiment showed that we could obtain more accurate and sparse predictor for survival analysis by the L(1/2) regularized AFT model compared with other L1 type regularization methods. The proposed procedures are applied to five real DNA microarray datasets to efficiently predict the survival time of patient based on a set of clinical prognostic factors and gene signatures.

  7. Spectroscopy of Single Light-Harvesting Complexes from Purple Photosynthetic Bacteria at 1.2 K

    NARCIS (Netherlands)

    Oijen, A.M. van; Ketelaars, M.; Köhler, J.; Aartsma, T.J.; Schmidt, J.

    1998-01-01

    In this Letter we present the first observation of the fluorescence-excitation spectra of individual light-harvesting complexes (LH2) from purple photosynthetic bacteria at 1.2 K. The spectra reveal the electronic transitions to the individual excitonic states of the assembly of absorbing

  8. Barlowite: A Spin-1/2 Antiferromagnet with a Geometrically Perfect Kagome Motif.

    Science.gov (United States)

    Han, Tian-Heng; Singleton, John; Schlueter, John A

    2014-11-28

    We present thermodynamic studies of a new spin-1/2 antiferromagnet containing undistorted kagome lattices-barlowite Cu_{4}(OH)_{6}FBr. Magnetic susceptibility gives θ_{CW}=-136  K, while long-range order does not happen until T_{N}=15  K with a weak ferromagnetic moment μkagome lattice makes charge doping promising.

  9. Neutron-scattering cross section of the S=1/2 Heisenberg triangular antiferromagnet

    DEFF Research Database (Denmark)

    Lefmann, K.; Hedegård, P.

    1994-01-01

    In this paper we use a Schwinger-boson mean-field approach to calculate the neutron-scattering cross section from the S = 1/2 antiferromagnet with nearest-neighbor isotropic Heisenberg interaction on a two-dimensional triangular lattice. We investigate two solutions for T = 0: (i) a state with long...

  10. Chiral pyrrolo[1,2-a]quinolines as second-order nonlinear optical materials

    NARCIS (Netherlands)

    Kelderman, E.; Kelderman, E.; Verboom, Willem; Engbersen, Johannes F.J.; Harkema, Sybolt; Heesink, G.J.T.; Heesink, G.J.T.; Lehmusvaara, E.; van Hulst, N.F.; Reinhoudt, David; Derhaeg, L.; Persoons, A.

    1992-01-01

    The synthesis and nonlinear optical properties of a series of chiral pyrrolo[1,2-a]quinolines la-e is presented. The microscopic hyperpolarizabilities (beta(z)) were determined by EFISH measurements and the macroscopic susceptibilities (X2) were estimated by the Kurtz powder test. A small fixed

  11. Exact solutions for spin-1/2 systems using dynamical manipulation techniques

    CERN Document Server

    Fernández-Cesar, C; Rosas-Ortiz, Oscar

    1997-01-01

    The dynamics of purely spin-1/2 systems in homogeneous magnetic fields is analysed through inverse techniques. The generation of exact solutions using this method is explored. Some cases of the "evolution loops", dynamical processes for which any state evolves cyclically, are presented, and the corresponding geometric phases are evaluated.

  12. Room-temperature 1.2-J Fe{sup 2+}:ZnSe laser

    Energy Technology Data Exchange (ETDEWEB)

    Velikanov, S D; Zaretsky, N A; Zotov, E A; Maneshkin, A A; Yutkin, I M [Russian Federal Nuclear Center ' All-Russian Research Institute of Experimental Physics' , Sarov, Nizhnii Novgorod region (Russian Federation); Kazantsev, S Yu; Kononov, I G; Firsov, K N [A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation); Korostelin, Yu V; Frolov, M P [P N Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

    2016-01-31

    The characteristics of a laser based on a Fe{sup 2+}:ZnSe single crystal pumped by an electric-discharge HF laser at room temperature are studied. The HF laser beam diameter on the crystal surface was 17 mm. The achieved laser energy was 1.2 J with an efficiency of ∼ 25% with respect to the pump energy. (letters)

  13. Quasilocal Conserved Operators in the Isotropic Heisenberg Spin-1/2 Chain.

    Science.gov (United States)

    Ilievski, Enej; Medenjak, Marko; Prosen, Tomaž

    2015-09-18

    Composing higher auxiliary-spin transfer matrices and their derivatives, we construct a family of quasilocal conserved operators of isotropic Heisenberg spin-1/2 chain and rigorously establish their linear independence from the well-known set of local conserved charges.

  14. Quasilocal Conserved Operators in the Isotropic Heisenberg Spin-1/2 Chain

    NARCIS (Netherlands)

    Ilievski, E.; Medenjak, M.; Prosen, T.

    2015-01-01

    Composing higher auxiliary-spin transfer matrices and their derivatives, we construct a family of quasilocal conserved operators of isotropic Heisenberg spin-1/2 chain and rigorously establish their linear independence from the well-known set of local conserved charges.

  15. Body weight and risk of breast cancer in BRCA1/2 mutation carriers

    NARCIS (Netherlands)

    Manders, Peggy; Pijpe, Anouk; Hooning, Maartje J.; Kluijt, Irma; Vasen, Hans F. A.; Hoogerbrugge, Nicoline; van Asperen, Christi J.; Meijers-Heijboer, Hanne; Ausems, Margreet G. E. M.; van Os, Theo A.; Gomez-Garcia, Encarna B.; Brohet, Richard M.; van Leeuwen, Flora E.; Rookus, Matti A.

    Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a

  16. BaMnO3 and Ba1/2Sr1/2MnO3 Nanoparticles Synthesized by CHM Method%CHM法合成BaMnO3、Ba1/2Sr1/2MnO3纳米晶体

    Institute of Scientific and Technical Information of China (English)

    夏川茴; 胡陈果; 韩向宇; 王娜; 张祖伟

    2008-01-01

    采用复合碱媒介法(CHM),以BaCl和MnO2为原料在200 ℃、24 h的生长条件下合成了纳米BaMnO3单晶颗粒.采用同样方法,以Sr(NO3)2、BaCO3以及MnO2为原料,在200 ℃、24 h的生长条件下,用50%的Sr替代50%的Ba,成功合成了Ba1/2Sr1/2MnO3.用X射线衍射仪(XRD)、扫描电镜(SEM)及能量散射X射线谱(EDS)对产物的晶相、形貌和成分进行了分析,并且解释了BaMnO3及Ba1/2Sr1/2MnO3的生长机理.

  17. Mechanism of 1,2-shift through π-complex transition state

    Institute of Scientific and Technical Information of China (English)

    戴乾圜; 周志刚; 张大平

    2000-01-01

    A systematic calculation of the potential curves or surfaces for 1,2-shift has been realized by using MNDO or other models in MOPAC programs. By referring to the previous authors’ viewpoints, the 1,2-shift can be divided into two categories. 1,2-electron-deficient shift is that the electronic configuration of the atom which accepts the migrating group is a cation or an electron-deficient atom, and 1,2-anion shift is the one that the accepted atom of the migration group is a negative ion. In terms of the experimental facts and the calculation of the potential surfaces, in electron-deficient shift such as Beckmann or Baeyer-Villiger rearrangement, the migration occurs through a transition complex formed between the 7i-bond and the cation or electron-deficient migrating group, but in anion shift such as Wittig or Stevens rearrangement, the electron pair in it-orbit excites at first to π* orbit, and then the migration occurs through the new formed complex between the anion migration group and the vacant rc

  18. Spectroscopy of Single Light-Harvesting Complexes from Purple Photosynthetic Bacteria at 1.2 K

    NARCIS (Netherlands)

    Oijen, A.M. van; Ketelaars, M.; Köhler, J.; Aartsma, T.J.; Schmidt, J.

    1998-01-01

    In this Letter we present the first observation of the fluorescence-excitation spectra of individual light-harvesting complexes (LH2) from purple photosynthetic bacteria at 1.2 K. The spectra reveal the electronic transitions to the individual excitonic states of the assembly of absorbing bacterioch

  19. Green Synthesis of Carvenone by Montmorillonite-Catalyzed Isomerization of 1,2-Limonene Oxide

    DEFF Research Database (Denmark)

    Nguyen, Thao-Tran Thi; Chau, Duy-Khiem Nguyen; Duus, Fritz;

    2013-01-01

    Montmorillonite was considered as a good heterogeneous catalyst for the isomerization of 1,2-limonene oxide into car-venone under solvent-free condition. Both conventional heating and green activations were tested in this research. The microwave-assisted isomerization afforded carvenone in high...

  20. Room-temperature 1.2-J Fe2+:ZnSe laser

    Science.gov (United States)

    Velikanov, S. D.; Zaretsky, N. A.; Zotov, E. A.; Kazantsev, S. Yu; Kononov, I. G.; Korostelin, Yu V.; Maneshkin, A. A.; Firsov, K. N.; Frolov, M. P.; Yutkin, I. M.

    2016-01-01

    The characteristics of a laser based on a Fe2+:ZnSe single crystal pumped by an electric-discharge HF laser at room temperature are studied. The HF laser beam diameter on the crystal surface was 17 mm. The achieved laser energy was 1.2 J with an efficiency of ~ 25% with respect to the pump energy.

  1. Erk1/2 mediates leptin receptor signaling in the ventral tegmental area.

    Directory of Open Access Journals (Sweden)

    Richard Trinko

    Full Text Available Leptin acts on the ventral tegmental area (VTA to modulate neuronal function and feeding behavior in rats and mice. To identify the intracellular effectors of the leptin receptor (Lepr, downstream signal transduction events were assessed for regulation by direct leptin infusion. Phosphorylated signal transducer and activator of transcription 3 (pSTAT3 and phosphorylated extracellular signal-regulated kinase-1 and -2 (pERK1/2 were increased in the VTA while phospho-AKT (pAKT was unaffected. Pretreatment of brain slices with the mitogen-activated protein kinase kinase -1 and -2 (MEK1/2 inhibitor U0126 blocked the leptin-mediated decrease in firing frequency of VTA dopamine neurons. The anorexigenic effects of VTA-administered leptin were also blocked by pretreatment with U0126, which effectively blocked phosphorylation of ERK1/2 but not STAT3. These data demonstrate that pERK1/2 may have a critical role in mediating both the electrophysiogical and behavioral effects of leptin receptor signaling in the VTA.

  2. Binary phase diagram of monolayers of simple 1,2-diol derivatives

    DEFF Research Database (Denmark)

    Wolf, C. De; Bringezu, F.; Brezesinski, G.;

    1998-01-01

    The miscibility properties of monolayers of two 1,2-diol derivatives, 1-palmitoylglycerol (1) and 1-hexadecylglycerol (2), have been studied at the air-water interface using grazing incidence X-ray diffraction (GIXD). While, at all pressures investigated, compound (I) exhibits only a NN...

  3. Renormalizability of N=1/2 Wess-Zumino model in superspace

    CERN Document Server

    Romagnoni, A

    2003-01-01

    In this letter we use the spurion field approach adopted in order to show that by adding F and F^2 terms to the original lagrangian, the N=1/2 Wess-Zumino model is renormalizable to all orders in perturbation theory. We reformulate in superspace language the proof given in the recent work in terms of component fields.

  4. 26 CFR 36.3121(l)(1)-2 - Amendment of agreement.

    Science.gov (United States)

    2010-04-01

    ... under the same conditions, with respect to any one or more of the foreign subsidiaries of the domestic...) EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE CONTRACT COVERAGE OF EMPLOYEES OF FOREIGN SUBSIDIARIES § 36.3121(l)(1)-2 Amendment of agreement. (a) An agreement entered into by a domestic...

  5. Implementation of OpenSSL API’s for TLS 1.2 Operation

    Directory of Open Access Journals (Sweden)

    Maria Navin J R

    2013-09-01

    Full Text Available OpenSSL is a popular and effective open source version of SSL/TLS, the most widely used protocol for secure network communications to provide data unity and secrecy between two different applications. TLS 1.2 is currently the most secure and up to date version of the standard. The main advantages of TLS 1.2 over previous versions are: It fixes cryptography flaws over previous version, supports additional crypto algorithms and supports flexibility in defining those algorithms. Fixing of flaws increases security which can be achieved by modifying the protocol to meet the better requirement and constraints for security needed. OpenSSL is a high quality package used by many of the commercial products available in the market. Achieving RFC compliance is very important for commercial products, as OpenSSL does not support TLS 1.2, the main objective of this paper is to show how TLS 1.2 can be supported in OpenSSL.

  6. [4 + 2] Annulation of Donor-Acceptor Cyclopropanes with Acetylenes Using 1,2-Zwitterionic Reactivity.

    Science.gov (United States)

    Novikov, Roman A; Tarasova, Anna V; Denisov, Dmitry A; Borisov, Denis D; Korolev, Victor A; Timofeev, Vladimir P; Tomilov, Yury V

    2017-02-23

    A new process for the [4 + 2] annulation of donor-acceptor cyclopropanes with acetylenes under the effect of anhydrous GaCl3 using 1,2-zwitterion reactivity was elaborated. The reaction opens access to substituted dihydronaphthalenes, naphthalenes, and other fused carbocycles. The direction of the reaction can be efficiently controlled by temperature.

  7. Body weight and risk of breast cancer in BRCA1/2 mutation carriers

    NARCIS (Netherlands)

    Manders, P.; Pijpe, A.; Hooning, M.J.; Kluijt, I.; Vasen, H.F.; Hoogerbrugge, N.; Asperen, C.J. van; Meijers-Heijboer, H.; Ausems, M.G.; Os, T.A. van; Gomez-Garcia, E.B.; Brohet, R.M.; Leeuwen, F.E. van; Rookus, M.A.; Ligtenberg, M.J.L.

    2011-01-01

    Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a

  8. Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma

    DEFF Research Database (Denmark)

    Plesner, Torben; Arkenau, Hendrik-Tobias; Gimsing, Peter

    2016-01-01

    Daratumumab, a human CD38 IgG1κ monoclonal antibody, has activity as monotherapy in multiple myeloma (MM). This phase 1/2 study investigated daratumumab plus lenalidomide/dexamethasone in refractory and relapsed/refractory MM. Part 1 (dose-escalation) evaluated 4 daratumumab doses plus lenalidomi...

  9. Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma

    NARCIS (Netherlands)

    Plesner, Torben; Arkenau, Hendrik-Tobias; Gimsing, Peter; Krejcik, Jakub; Lemech, Charlotte; Minnema, Monique C; Lassen, Ulrik; Laubach, Jacob P; Palumbo, Antonio; Lisby, Steen; Basse, Linda; Wang, Jianping; Sasser, A Kate; Guckert, Mary E; de Boer, Carla; Khokhar, Nushmia Z; Yeh, Howard; Clemens, Pamela L; Ahmadi, Tahamtan; Lokhorst, Henk M; Richardson, Paul G

    2016-01-01

    Daratumumab, a human CD38 IgG1κ monoclonal antibody, has activity as monotherapy in multiple myeloma (MM). This phase 1/2 study investigated daratumumab plus lenalidomide/dexamethasone in refractory and relapsed/refractory MM. Part 1 (dose-escalation) evaluated 4 daratumumab doses plus lenalidomide

  10. Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia

    Directory of Open Access Journals (Sweden)

    Philipp Spitzer

    2011-01-01

    Full Text Available Cerebrospinal fluid (CSF samples from 33 patients with Alzheimer dementia (AD, 21 patients with mild cognitive impairment who converted to AD during followup (MCI-AD, 25 patients with stable mild cognitive impairment (MCI-stable, and 16 nondemented subjects (ND were analyzed with a chemiluminescence immunoassay to assess the levels of the mitogen-activated protein kinase ERK1/2 (extracellular signal-regulated kinase 1/2. The results were evaluated in relation to total Tau (tTau, phosphorylated Tau (pTau, and beta-amyloid 42 peptide (Aβ42. CSF-ERK1/2 was significantly increased in the AD group as compared to stable MCI patients and the ND group. Western blot analysis of a pooled cerebrospinal fluid sample revealed that both isoforms, ERK1 and ERK2, and low amounts of doubly phosphorylated ERK2 were detectable. As a predictive diagnostic AD biomarker, CSF-ERK1/2 was inferior to tTau, pTau, and Aβ42.

  11. Accardi complementarity for -1/2 < mu < 0 and related results

    OpenAIRE

    Cepeda, Lenin A. Echavarria; Ruiz, Claudio Pita; Sontz, Stephen B.

    2007-01-01

    We show (an earlier conjecture of the last two authors) that the momentum and position operators of mu-deformed quantum mechanics for -1/2 < mu < 0 are not Accardi complementary. We also prove some related formulas that were conjectured by the same authors.

  12. Why the Faulhaber Polynomials Are Sums of Even or Odd Powers of (n + 1/2)

    Science.gov (United States)

    Hersh, Reuben

    2012-01-01

    By extending Faulhaber's polynomial to negative values of n, the sum of the p'th powers of the first n integers is seen to be an even or odd polynomial in (n + 1/2) and therefore expressible in terms of the sum of the first n integers.

  13. II kvartalis jääb saamata 1,2 miljonit krooni trahvi / Urmas Jaagant

    Index Scriptorium Estoniae

    Jaagant, Urmas

    2010-01-01

    Tallinna transpordiameti prognoosi kohaselt on II kvartalis ebaõenäoline 282 400 krooni parkimistrahvide, 779 385 krooni parkimistrahvide viiviste ja 187 188 krooni teede ja tänavate sulgemise maksunõuete laekumine, transpordiamet saab 1,2 mln. krooni ebatõenäoliselt laekuvate nõuete allahindamiseks

  14. Neutrino oscillograms of the Earth: effects of 1-2 mixing and CP-violation

    CERN Document Server

    Akhmedov, Evgeny Kh; Smirnov, Alexei Yu

    2008-01-01

    We develop a comprehensive description of three flavor neutrino oscillations inside the Earth in terms of neutrino oscillograms in the whole range of nadir angles and for energies above 0.1 GeV. The effects of the 1-2 mass splitting and mixing as well the interference of the 1-2 and 1-3 modes of oscillations are quantified. The 1-2 mass splitting and mixing lead to the appearance, apart from the resonance MSW peaks, of the parametric resonance peak for core-crossing trajectories at E_nu ~= 0.2 GeV. We show that the interference effects, in particular CP violation, have a domain structure with borders determined by the solar and atmospheric magic lines and the lines of the interference phase condition. The dependence of the oscillograms on the Dirac CP-violating phase is studied. We show that for sin^2(2 theta13) << 0.1 the strongest dependence of the oscillograms on delta is in the 1-2 and 1-3 resonance regions.

  15. Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma

    NARCIS (Netherlands)

    Plesner, Torben; Arkenau, Hendrik-Tobias; Gimsing, Peter; Krejcik, Jakub; Lemech, Charlotte; Minnema, Monique C; Lassen, Ulrik; Laubach, Jacob P; Palumbo, Antonio; Lisby, Steen; Basse, Linda; Wang, Jianping; Sasser, A Kate; Guckert, Mary E; de Boer, Carla; Khokhar, Nushmia Z; Yeh, Howard; Clemens, Pamela L; Ahmadi, Tahamtan; Lokhorst, Henk M; Richardson, Paul G

    2016-01-01

    Daratumumab, a human CD38 IgG1κ monoclonal antibody, has activity as monotherapy in multiple myeloma (MM). This phase 1/2 study investigated daratumumab plus lenalidomide/dexamethasone in refractory and relapsed/refractory MM. Part 1 (dose-escalation) evaluated 4 daratumumab doses plus lenalidomide

  16. 14 CFR Sec. 1-2 - Waivers from this system of accounts and reports.

    Science.gov (United States)

    2010-01-01

    ... AIR CARRIERS General Accounting Provisions Sec. 1-2 Waivers from this system of accounts and reports. A waiver from any provision of this system of accounts or reports may be made by the BTS upon its... the principles embodied in the provisions of this system of accounts and reports; and the...

  17. New Universality Class in the S=1/2 Fibonacci Heisenberg Chains

    OpenAIRE

    Hida, Kazuo

    2004-01-01

    Low energy properties of the S=1/2 antiferromagnetic Heisenberg chains with Fibonacci exchange modulation are studied using the real space renormalization group method for strong exchange modulation. It is found that the ground state of this model belongs to a new universality class with logarithmically divergent dynamical exponent which is neither like Fibonacci XY chains nor like XY chains with relevant aperiodicity.

  18. Radii in the $sd$ shell and the $s_{1/2}$ "halo" orbit: A game changer

    CERN Document Server

    Bonnard, J

    2016-01-01

    Proton radii of nuclei in the $sd$ shell depart appreciably from the asymptotic law, $\\rho_{\\pi}=\\rho_0A^{1/3}$. The departure exhibits systematic trends fairly well described by a single phenomenological term in the Duflo-Zuker formulation, which also happens to explain the sudden increase in slope in the isotope shifts of several chains at neutron number $N=28$. It was recently shown that this term is associated with the abnormally large size of the $s_{1/2}$ and $p$ orbits in the $sd$ and $pf$ shells respectively. Further to explore the problem, we propose to calculate microscopically radii in the former. Since the (square) radius is basically a one body operator, its evolution is dictated by single particle occupancies determined by shell model calculations. Assuming that the departure from the asymptotic form is entirely due to the $s_{1/2}$ orbit, the expectation value $\\langle s_{1/2}|r^2|s_{1/2}\\rangle$ is determined by demanding that its evolution be such as to describe well nuclear radii. It does, f...

  19. Synthesis and Antimicrobial Evaluation of 1-[(2-Substituted phenylcarbamoyl]naphthalen-2-yl Carbamates

    Directory of Open Access Journals (Sweden)

    Tomas Gonec

    2016-09-01

    Full Text Available Series of thirteen 1-[(2-chlorophenylcarbamoyl]naphthalen-2-yl carbamates and thirteen 1-[(2-nitrophenylcarbamoyl]naphthalen-2-yl carbamates with alkyl/cycloalkyl/arylalkyl chains were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, two methicillin-resistant S. aureus strains, Mycobacterium marinum, and M. kansasii. 1-[(2-Chlorophenylcarbamoyl]naphthalen-2-yl ethylcarbamate and 1-[(2-nitrophenylcarbamoyl]naphthalen-2-yl ethylcarbamate showed antistaphylococcal (MICs = 42 µM against MRSA and antimycobacterial (MICs = 21 µM activity against the tested strains comparable with or higher than that of the standards ampicillin and isoniazid. In the case of bulkier carbamate tails (R > propyl/isopropyl, the activity was similar (MICs ca. 70 µM. Screening of the cytotoxicity of both of the most effective compounds was performed using THP-1 cells, and no significant lethal effect was observed (LD50 >30 µM. The structure-activity relationships are discussed.

  20. An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

    Directory of Open Access Journals (Sweden)

    Rajeshwar Reddy Sagyam

    2009-11-01

    Full Text Available The reaction of 2-[2-(4-fluorophenyl-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.

  1. An Analysis of Kohlberg's "Stage 4 1/2" within an Enhanced Framework of Moral Stages.

    Science.gov (United States)

    Minnameier, Gerhard

    This paper discusses a well-known problem of stage categorization within Kohlberg's theory of moral stages (L. Kohlberg, 1973), that of "Stage 4 1/2." Some subjects previously scored at stage 4 in Kohlberg's framework took on some characteristics of stage 2 reasoning, which suggested the possibility of regression. To reconcile this…

  2. Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation

    Directory of Open Access Journals (Sweden)

    Heun Joo Lee

    2015-08-01

    Full Text Available Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanogenic effect of hespiridin as well as its underlying molecular mechanisms. Melanin contents were measured in normal human melanocytes and B16F10 melanoma cells. Protein and mRNA levels of tyrosinase, microphthalmia-associated transcription factor (MITF, tyrosinase related protein-1 (TRP-1 and TRP-2 were determined. Melanogenesis-regulating signals were examined. In results, hesperidin strongly inhibited melanin synthesis and tyrosinase activity. Hesperidin decreased tyrosinase, TRP-1, and TRP-2 protein expression but increased phospho-extracellular signal-regulated kinase 1/2 (p-Erk1/2 expression. Specific inhibitor of Erk1/2 or proteasome inhibitor reversed the inhibition of melanogenesis induced by hesperidin. Taken together, hesperidin, a popular antioxidant, stimulated Erk1/2 phosphorylation which subsequently degraded MITF which resulted in suppression of melanogenic enzymes and melanin synthesis.

  3. 17 CFR 240.15c1-2 - Fraud and misrepresentation.

    Science.gov (United States)

    2010-04-01

    ... any act, practice, or course of business which operates or would operate as a fraud or deceit upon any... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Fraud and misrepresentation... Securities Exchange Act of 1934 Rules Relating to Over-The-Counter Markets § 240.15c1-2 Fraud...

  4. Reaction of β-enaminones and acetylene dicarboxylates: synthesis of substituted 1,2-dihydropyridinones.

    Science.gov (United States)

    Nagaraju, Vemu; Purnachander, Dalovai; Mangina, N S V M Rao; Suresh, Surisetti; Sridhar, Balasubramanian; Karunakar, Galla V

    2015-03-14

    Synthesis of substituted 1,2-dihydropyridinones is described in a one pot reaction of β-enaminones and acetylene dicarboxylates where new C-C and C-N bonds were formed. The title compounds were obtained in moderate to good yields.

  5. Risk-reducing mastectomy in BRCA1/2 mutation carriers : Factors influencing uptake and timing

    NARCIS (Netherlands)

    van Driel, Catheleine M.; Eltahir, Yassir; de Vries, J; Jaspers, Jan P.; Oosterwijk, Jan C.; Mourits, Marian J.; de Bock, Geertruida H.

    2014-01-01

    INTRODUCTION: Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screening or risk-reducing mastectomy (RRM). Both options have a high physical and psychosexual impact. The aim of this study is to investigate who chooses when to undergo R

  6. Infrared Spectroscopic Analysis of Chrysene and 1.2-Benzanthracence in Wax films

    Institute of Scientific and Technical Information of China (English)

    Md. Naziruddin Khan; A. S. Al-Dwayyan; Z. H. Zaidi

    2006-01-01

    @@ Chrysene and 1.2-benzanthracene are successfully doped in a solid wax film and their vibrational spectra in2000-400 cm- 1 are discussed. The harmonic frequencies and relative intensities of both the molecules observed in the film are compared with theoretical values calculated by the density functional theory (DFT) model as well as with the previous experimental data.

  7. Obtención de Dímeros por Termólisis de 1,2-Propanodiol Synthesis of Dimers from Thermolysis of 1,2-Propanediol

    Directory of Open Access Journals (Sweden)

    Nathaly Milanés

    2012-01-01

    Full Text Available Los compuestos dímeros 3-oxi-(bis-2-propanol, 2-(2-hidroxipropoxi-propanol y 2-oxi-(bis-propanol fueron obtenidos de la reacción de descomposición térmica del 1,2-propanodiol, realizada a 573.15 K y a su presión de vapor, utilizando un sistema de reacción a microescala, Los dímeros resultaron ser isómeros y fueron elucidados por cromatografía gaseosa acoplada a espectrometría de masas. E stos compuestos no han sido reportados en la literatura como productos de termólisis de polioles. La cinética y el mecanismo, fueron confirmados por cálculos computacionales utilizando el método de la Teoría del Funcional Densidad, DFT. E l mecanismo propuesto transcurrió a través de un proceso concertado de una sola etapa, que pasa por un estado de transición cíclico de cuatro miembros , compatible con cálculos cinéticos y termodinámicos.The dimers 3-oxy-(bys-2-propanol, 2-(2-hydroxypropoxy-propanol and 2-oxy-(bys-propanol were obtained from the thermal decomposition reaction of 1,2-propanediol , at 573.15 K and to its vapor pressure, and using microscale reaction system. The dimers resulted to be isomers and were elucidated by gas chromatography coupled to mass spectrometry. These compounds have not been reported in literature as products polyol thermolysis. The kinetic and the mechanism were validated by computational calculations using the Density Functional Theory, DFT. The proposed mechanism occurred in a single step concerted process that passes through a four member transition cyclical state that is compatible with kinetic and thermodynamic calculations.

  8. Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.

    Science.gov (United States)

    M'Barek, Sarrah; Chagot, Benjamin; Andreotti, Nicolas; Visan, Violeta; Mansuelle, Pascal; Grissmer, Stephan; Marrakchi, Mohamed; El Ayeb, Mohamed; Sampieri, François; Darbon, Hervé; Fajloun, Ziad; De Waard, Michel; Sabatier, Jean-Marc

    2005-08-15

    Scorpion toxins interact with their target ion channels through multiple molecular contacts. Because a "gain of function" approach has never been described to evaluate the importance of the molecular contacts in defining toxin affinity, we experimentally examined whether increasing the molecular contacts between a toxin and an ion channel directly impacts toxin affinity. For this purpose, we focused on two scorpion peptides, the well-characterized maurotoxin with its variant Pi1-like disulfide bridging (MTX(Pi1)), used as a molecular template, and butantoxin (BuTX), used as an N-terminal domain provider. BuTX is found to be 60-fold less potent than MTX(Pi1) in blocking Kv1.2 (IC(50) values of 165 nM for BuTX versus 2.8 nM for MTX(Pi1)). Removal of its N-terminal domain (nine residues) further decreases BuTX affinity for Kv1.2 by 5.6-fold, which is in agreement with docking simulation data showing the importance of this domain in BuTX-Kv1.2 interaction. Transfer of the BuTX N-terminal domain to MTX(Pi1) results in a chimera with five disulfide bridges (BuTX-MTX(Pi1)) that exhibits 22-fold greater affinity for Kv1.2 than MTX(Pi1) itself, in spite of the lower affinity of BuTX as compared to MTX(Pi1). Docking experiments performed with the 3-D structure of BuTX-MTX(Pi1) in solution, as solved by (1)H-NMR, reveal that the N-terminal domain of BuTX participates in the increased affinity for Kv1.2 through additional molecular contacts. Altogether, the data indicate that acting on molecular contacts between a toxin and a channel is an efficient strategy to modulate toxin affinity. (c) 2005 Wiley-Liss, Inc.

  9. Taurine Inhibits Myocardial Fibrosis via PKC-ERK1/2 Signaling Pathways

    Institute of Scientific and Technical Information of China (English)

    WANG Li-ying; LI Hong; YANG Shi-jie

    2012-01-01

    Previous studies have demonstrated the important role of taurine in inhibiting proliferation of myofibroblasts(myoFb) and myocardial fibrosis.However,the underlying mechanisms are unclear.The present study was designed to shed light on this issue through exploring the signal pathways via in vitro experiments.Angiotension Ⅱ (AngⅡ) treatment significantly increased myoFb proliferation and the levels of collagens Ⅰ and Ⅲ(P<0.05),whereas taurine,PKCαt(PKC:protein kinase C) specific inhibitor L-threo-dihydro-sphingosine(D4681),ERK1/2 inhibitor (PD98095) abrogated myoFb proliferation and collagen levels(P<0.05,P<0.01,respectively),and increased the G0/G1 phase rate and decreased S phase rate.Immunocytochemistry,confocal fluorescence staining and image analysis showed that taurine could inhibit the translocation and expression of p-PKCαtin membrane,and then inhibit nuclear translocation and expression of p-ERK1/2.These results have statistically significant differences compared with those of AngⅡ group(P<0.0l).Western blot results also show that taurine could inhibit the protein expression of p-PKCαt and p-ERK1/2.We used p-PKCα specific inhibitor D4681 in order to elucidate the relationship between p-PKCα and p-ERK1/2 in signal transduction pathways.Finally,the results show that the protein expression of p-ERK1/2 and nuclear translocation were suppressed in D4681 group.

  10. A new interaction between proximal and distal C-terminus of Cav1.2 channels

    Directory of Open Access Journals (Sweden)

    Liting Lyu

    2017-04-01

    Full Text Available Cardiac Cav1.2 channels, coupling membrane stimulation to intracellular Ca2+ signaling, are regulated by multiple cytoplasmic factors, such as calmodulin (CaM, phosphorylation, Ca2+, ATP and intramolecular fragments of the channel. The interaction between distal and proximal C-terminal regulatory domains (DCRD and PCRD of Cav1.2 channel is suggested to inhibit the channel activity, while PKA-mediated phosphorylation facilitates Cav1.2 channel by releasing such an interaction. Here, we report that the interaction between the distal C-terminus (CT3 and the proximal C-terminus (CT1 are inhibited by CaM in a Ca2+-dependent manner. Furthermore, CT3D (a short CT3 with DCRD truncated interacts with CT1B (a short CT1 with EF-hand and PCRD truncated, revealing a new interaction between distal and proximal C-terminus. Ca2+/CaM inhibited the binding of CT3D to CT1B more strongly than the binding between CT3 and CT1, implying that the interaction of DCRD/PCRD (in CT3/CT1 might cooperate with the binding of CT3D to CT1B. We name the new CT1B-binding region of CT3D as CaM-competitive domain (CCD. The electrophysiological experiments show that CT3D inhibits while CT1B facilitates Cav1.2 channel activity in inside-out patches in guinea-pig ventricular myocytes. These results suggest that distal C-terminus inhibits Cav1.2 channel through modulation of the CaM-binding property of the channels.

  11. File list: Oth.Emb.05.AllAg.1-2h_embryos [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Emb.05.AllAg.1-2h_embryos dm3 TFs and others Embryo 1-2h embryos SRX197583,SRX1...97584 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Emb.05.AllAg.1-2h_embryos.bed ...

  12. STABILITY OF HEMOGLOBIN AND ALBUMIN ADDUCTS OF NAPHTHALENE OXIDE, 1,2-NAPHTHOQUINONE, AND 1,4-NAPHTHOQUINONE

    Science.gov (United States)

    Naphthalene is an important industrial chemical, which has recently been shown to cause tumors of the respiratory tract in rodents. It is thought that one or more reactive metabolites of naphthalene, namely, naphthalene-1,2-oxide (NPO), 1,2-naphthoquinone (1,2-NPQ), and 1,4-na...

  13. Purification of 1,2-diacylglycerols from vegetable oils: comparison of molecular distillation and liquid CO2 extraction

    Science.gov (United States)

    High oleic sunflower oil and soybean oil were partially deacylated by enzyme-catalyzed propanolysis using Lipozyme TL IM to form 1,2-diacyl-sn-glycerols (1,2-DAG) in 40% yields. 1,2-DAG are of interest as potential regiospecific intermediates in the synthesis of structured lipids for cosmeceutical ...

  14. Biomechanical analysis of Goel technique for C1-2 fusion.

    Science.gov (United States)

    Park, Jon; Scheer, Justin K; Lim, T Jesse; Deviren, Vedat; Ames, Christopher P

    2011-05-01

    The Goel technique, in which C1-2 intraarticular spacers are used, may be performed to restore stability to a disrupted atlantoaxial complex in conjunction with the Harms technique of placing polyaxial screws and bilateral rods. However, it has yet to be determined biomechanically whether the addition of the C1-2 joint spacers increases the multiaxial rigidity of the fixation construct. The goal of this study was to quantify changes in multiaxial rigidity of the combined Goel-Harms technique with the addition of C1-2 intraarticular spacers. Seven cadaveric cervical spines (occiput-C2) were submitted to nondestructive flexion-extension, lateral bending, and axial rotation tests in a material testing machine spine tester. The authors applied 1.5 Nm at a rate of 0.1 Nm/second and held it constant for 10 seconds. The specimens were loaded 3 times, and data were collected on the third cycle. Testing of the specimens was performed for the following groups: 1) intact (I); 2) with the addition of C-1 lateral mass/C-2 pedicle screws and rod system (I+SR); 3) with C1-2 joint capsule incision, decortication (2 mm on top and bottom of each joint [that is, the C-1 and C-2 surface) and addition of bilateral C1-2 intraarticular spacers at C1-2 junction to the screws and rods (I+SR+C); 4) after removal of the posterior rods and only the bilateral spacers in place (I+C); 5) after removal of spacers and further destabilization with simulated odontoidectomy for a completely destabilized case (D); 6) with addition of posterior rods to the destabilized case (D+SR); and 7) with addition of bilateral C1-2 intraarticular spacers at C1-2 junction to the destabilized case (D+SR+C). The motion of C-1 was measured by a 3D motion tracking system and the motion of C-2 was measured by the rotational sensor of the testing system. The range of motion (ROM) and neutral zone (NZ) across C-1 and C-2 were evaluated. For the intact spine test groups, the addition of screws/rods (I+SR) and screws/rods/cages (I+SR+C) significantly reduced ROM and NZ compared with the intact spine (I) for flexion-extension and axial rotation (p bending (p > 0.05). The 2 groups were not significantly different from each other in any bending mode for ROM and NZ, but in the destabilized condition the addition of screws/rods (D+SR) and screws/rods/cages (D+SR+C) significantly reduced ROM and NZ compared with the destabilized spine (D) in all bending modes (p bending) compared with the screws and rods alone (D+SR). Study result indicated that both the Goel and Harms techniques alone and with the addition of the C1-2 intraarticular spacers to the Goel-Harms technique are advantageous for stabilizing the atlantoaxial segment. The Goel technique combined with placement of a screw/rod construct appears to result in additional construct rigidity beyond the screw/rod technique and appears to be more useful in very unstable cases.

  15. Structure and electrical properties in the K{sub 1/2}Bi{sub 1/2}TiO{sub 3}-K{sub 1/2}Bi{sub 1/2}ZrO{sub 3} solid solution (KBT-KBZ)

    Energy Technology Data Exchange (ETDEWEB)

    Bengagi, M. [Laboratoire de Science des Procedes Ceramiques et de Traitements de Surface (SPCTS), UMR 7315 CNRS, Universite de Limoges, Centre Europeen de la Ceramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Laboratoire de Chimie Minerale Appliquee, Faculte des Sciences, Universite de Tunis El Manar, Campus Universitaire, 2092-El Manar Tunis (Tunisia); Morini, F.; Marchet, P. [Laboratoire de Science des Procedes Ceramiques et de Traitements de Surface (SPCTS), UMR 7315 CNRS, Universite de Limoges, Centre Europeen de la Ceramique, 12 rue Atlantis, 87068 Limoges Cedex (France); El Maaoui, M. [Laboratoire de Chimie Minerale Appliquee, Faculte des Sciences, Universite de Tunis El Manar, Campus Universitaire, 2092-El Manar Tunis (Tunisia)

    2012-10-15

    The present work is devoted to the study of the Zr{sup 4+}/Ti{sup 4} substitution in the K{sub 1/2}Bi{sub 1/2}Ti{sub (1-x)}Zr{sub x}O{sub 3} solid solution (x = 0.0 to x = 1.0), based upon the K{sub 1/2}Bi{sub 1/2}TiO{sub 3} (KBT) ferroelectric compound. The tetragonal distortion of KBT is suppressed by this substitution and leads to the cubic compound K{sub 1/2}Bi{sub 1/2}ZrO{sub 3} (KBZ). These results agree with the values of the ionic radii of the Zr{sup 4+} and Ti{sup 4} ions (r{sub Ti}{sup {sub 4} {sub +}} = 0.605 Aa and r{sub Zr}{sup {sub 4} {sub +}} = 0.72 Aa). Close to KBT (x {<=} 0.05), the symmetry remains tetragonal. For higher values of x, the ''a'' lattice parameter (cubic indexing) follows Vegard's law, thus confirming the formation of a solid solution. The transformation from tetragonal to cubic proceeds via an intermediate pseudocubic symmetry (0.1 {<=} x < 0.5), for which the X-ray diffraction peaks present small broadening and asymmetry. For x {>=} 0.5 and up to the KBZ compound (a {approx} 4.158 Aa), the samples are cubic but some extra peaks are also observed, indicating the occurrence of a secondary phase. The microstructure shows fine-grained ceramic samples for the first range, while for the KBZ-rich range the grains are micrometer-sized and associated to very small grains of the secondary phase. Piezoelectricity is observed for the tetragonal and pseudocubic range, the substitution quickly reducing the piezoelectric properties. The measurement of the dielectric properties revealed close to KBT a dielectric anomaly probably associated to the tetragonal-cubic phase transition. For the pseudocubic and cubic range, a broad dielectric anomaly is observed around 300 C, corresponding to a relaxor behavior. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. BRCA1/2 genetic testing uptake and psychosocial outcomes in men.

    Science.gov (United States)

    Graves, Kristi D; Gatammah, Rhoda; Peshkin, Beth N; Krieger, Ayelet; Gell, Christy; Valdimarsdottir, Heiddis B; Schwartz, Marc D

    2011-06-01

    Few studies have quantitatively evaluated the uptake and outcomes of BRCA1/2 genetic counseling and testing in men. We conducted a prospective longitudinal study to describe and compare uptake of and psychosocial outcomes following BRCA1/2 testing in a sample of men and women at high-risk for carrying a BRCA1/2 mutation. Men (n = 98) and women (n = 243) unaffected with cancer completed baseline assessments prior to genetic counseling and testing and then 6- and 12-months post-testing. Most men (n = 94; 95.9%) opted to have genetic testing, of whom 44 received positive BRCA1/2 genetic test results and 50 received true negative results. Among women, 93.4% had genetic testing, of whom 79 received positive results and 148 received negative results. In multivariate models, male BRCA1/2 carriers reported significantly higher genetic testing distress (6-months: Z = 4.48, P < 0.0001; 12-months: Z = 2.78, P < 0.01) than male non-carriers. After controlling for baseline levels of distress, no statistically significant differences emerged between male and female BRCA1/2 carriers in psychological distress at 12-months post-testing, although absolute differences were evident over time. Predictors of distress related to genetic testing among male carriers at 12-months included higher baseline cancer-specific distress (Z = 4.73, P < 0.0001) and being unmarried (Z = 2.18, P < 0.05). Similarly, baseline cancer-specific distress was independently associated with cancer-specific distress at 6- (Z = 3.66, P < 0.001) and 12-months (Z = 4.44, P < 0.0001) post-testing among male carriers. Clinically, our results suggest that pre-test assessment of distress and creation of educational materials specifically tailored to the needs and concerns of male carriers may be appropriate in this important but understudied high-risk group.

  17. Lattice dynamics and broad-band dielectric properties of multiferroic Pb(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Mackeviciute, R.; Greicius, S.; Grigalaitis, R.; Banys, J. [Faculty of Physics, Vilnius University, Sauletekio av. 9, III b. 817, LT-10222 Vilnius (Lithuania); Goian, V.; Nuzhnyy, D.; Kamba, S., E-mail: kamba@fzu.cz [Institute of Physics, The Czech Academy of Sciences, Na Slovance 2, 182 21 Prague 8 (Czech Republic); Holc, J. [Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana (Slovenia)

    2015-02-28

    Complex dielectric properties of Pb(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} ceramics were investigated in a broad frequency range from 100 Hz up to 90 THz. A broad dielectric anomaly was observed near the temperature of the ferroelectric phase transition (T{sub C1} = 376 K). Below 1 MHz, the anomaly is strongly influenced by conductivity of the sample, but higher frequency data taken up to 81 MHz reveal a broad and frequency independent peak at T{sub C1} typical for a diffuse ferroelectric phase transition. Surprisingly, dielectric permittivity measured at 37 GHz exhibits a peak shifted by 25 K above T{sub C1}, which indicates polar nanoregions with dynamics in microwave frequency region. A dielectric relaxation, which appears in THz region below 700 K, slows down towards T{sub C1} and again hardens below T{sub C2} = 356 K. This central mode drives both phase transitions, so they belong to order–disorder type, although the polar phonons exhibit anomalies near both phase transitions. In the paraelectric phase, infrared reflectivity spectra correspond to local Fm3{sup ¯}m structure due to short-range chemical ordering of Fe and Nb cations on the B perovskite sites. Moreover, each polar phonon is split due to two different cations on the B sites. Recently, Manley et al. [Nat. Commun. 5, 3683 (2014)] proposed a new mechanism of creation of polar nanoregions in relaxor ferroelectrics. They argued, based on their inelastic neutron scattering studies of PMN–PT, that the TO1 phonon is split and interaction of both components gives rise to so called Anderson phonon localization, which can produce regions of trapped standing waves and these waves induce polar nanoregions in relaxors. We cannot exclude or confirm this mechanism, but we show that the splitting of polar phonons is a common feature for all complex perovskites with relaxor ferroelectric behavior and it can be also observed in canonical ferroelectric BaTiO{sub 3}, where the soft mode is split in paraelectric phase due to a strong lattice anharmonicity.

  18. Lattice dynamics and broad-band dielectric properties of multiferroic Pb(Fe1/2Nb1/2)O3 ceramics

    Science.gov (United States)

    Mackeviciute, R.; Goian, V.; Greicius, S.; Grigalaitis, R.; Nuzhnyy, D.; Holc, J.; Banys, J.; Kamba, S.

    2015-02-01

    Complex dielectric properties of Pb(Fe1/2Nb1/2)O3 ceramics were investigated in a broad frequency range from 100 Hz up to 90 THz. A broad dielectric anomaly was observed near the temperature of the ferroelectric phase transition (TC1 = 376 K). Below 1 MHz, the anomaly is strongly influenced by conductivity of the sample, but higher frequency data taken up to 81 MHz reveal a broad and frequency independent peak at TC1 typical for a diffuse ferroelectric phase transition. Surprisingly, dielectric permittivity measured at 37 GHz exhibits a peak shifted by 25 K above TC1, which indicates polar nanoregions with dynamics in microwave frequency region. A dielectric relaxation, which appears in THz region below 700 K, slows down towards TC1 and again hardens below TC2 = 356 K. This central mode drives both phase transitions, so they belong to order-disorder type, although the polar phonons exhibit anomalies near both phase transitions. In the paraelectric phase, infrared reflectivity spectra correspond to local F m 3 ¯ m structure due to short-range chemical ordering of Fe and Nb cations on the B perovskite sites. Moreover, each polar phonon is split due to two different cations on the B sites. Recently, Manley et al. [Nat. Commun. 5, 3683 (2014)] proposed a new mechanism of creation of polar nanoregions in relaxor ferroelectrics. They argued, based on their inelastic neutron scattering studies of PMN-PT, that the TO1 phonon is split and interaction of both components gives rise to so called Anderson phonon localization, which can produce regions of trapped standing waves and these waves induce polar nanoregions in relaxors. We cannot exclude or confirm this mechanism, but we show that the splitting of polar phonons is a common feature for all complex perovskites with relaxor ferroelectric behavior and it can be also observed in canonical ferroelectric BaTiO3, where the soft mode is split in paraelectric phase due to a strong lattice anharmonicity.

  19. 1.2V低功耗时钟发生器设计%Design of A 1.2V Low-Power Clock Generator

    Institute of Scientific and Technical Information of China (English)

    徐壮; 俞慧月; 张辉; 林霞

    2011-01-01

    This phase-locked-loop clock generator is based on SMIC 65 nm CMOS process,which focuses on low power and low jitter design.The generator is droved by 1.2 V single power supply and the loop filter is integrated on the chip.A full differential ring-oscillator consisted of five delay cells is used to generate 100-800 MHz clock,and output frequency range is 12.5 -800 MHz.The power consumption is 1.54 mW at 800 MHz.The period jitter (pk-pk) is 75 ps and period jitter (rms) is 8.6 ps; the cycle-to-cycle jitter (pk-pk) is 132 ps and cycle-to-cycle (rms) is 14.1 ps.The area of the circuit is 84 μm2.%基于整数分频锁相环结构实现的时钟发生器,该时钟发生器采用低功耗、低抖动技术,在SMIC 65 nm CMOS工艺上实现.电路使用1.2V单一电源电压,并在片上集成了环路滤波器.其中,振荡器为电流控制、全差分结构的五级环形振荡器.该信号发生器可以产生的时钟频率范围为12.5 ~800MHz,工作在800 MHz时所需的功耗为1.54 mW,输出时钟的周期抖动为:pk-pk =75 ps,ms =8.6 ps;Cycle-to-Cycle抖动为:pk-pk =132 ps,rms=14.1 ps.电路的面积为84 μm2.

  20. 1.2m望远镜风载作用分析%Influence of wind loading on the 1.2 m telescope

    Institute of Scientific and Technical Information of China (English)

    周超; 杨洪波; 吴小霞; 张景旭

    2011-01-01

    Wind loading is one of the most important factors on large EO telescopes, which can affect the surface accuracy of primary and secondary mirrors and bring telescope pointing errors, results in the degradation of imaging accuracy and tracking performance of telescopes.In order to study the effect of wind loading on the telescope, the concept of wind loading was simply introduced and mathematical model of wind press spectrum was created.A precise model of the 1.2 m telescope assembly was established by using the finite element method.The primary mirror surface figure changes due to static wind loading and the telescope random responses due to dynamic wind loading were studied.The primary mirror surface deformation and telescope pointing error were calculated and their RMS values were 0.65 nm and 0.0156" respectively.The results indicate that all the errors induced by wind loading are allowable.%风载是影响地基大口径光电望远镜性能的重要因素之一,其作用会直接影响主次镜面型精度,引起望远镜指向误差,从而降低其成像精度和跟踪性能.为了研究风载对望远镜的影响程度,介绍了风载的概念,建立了风压力谱的数学模型.借助有限元法,建立了1.2 m望远镜系统的有限元模型,分析了主镜在静态风载压力下的面型变化,以及望远镜系统在动态风载作用下的随机响应情况.计算出风载引起主镜镜面变形RMS值为0.65nm,跟踪指向误差RMS值为0.0156 6″.结果表明:风载影响在精度允许范围之内.

  1. VIPERS: Unveiling the Combined Evolution of Galaxies and Large Scale Structure at 0.5≤z ≤1.2

    Science.gov (United States)

    Iovino, A.; Vipers Team

    2016-10-01

    The VIMOS Public Extragalactic Redshift Survey (VIPERS) is the largest redshift survey ever conducted with the ESO telescopes. It has used the Very Large Telescope to collect nearly 100,000 redshifts from the general galaxy population at 0.5≤ z ≤1.2. With a combination of volume and sampling density that is unique for these redshifts, VIPERS allows statistical measurements of galaxy clustering and related cosmological quantities to be obtained on an equal footing with classic results from local redshift surveys. At the same time, the broad selection function and ancillary photometric data provide detailed information on the physical properties of the galaxy population and their relation to large-scale structure. This talk presents an overview of the results obtained so far, mostly based on the ˜ 55,000 galaxies forming the first public data release (PDR-1).

  2. Nuclear phosphoproteomics analysis reveals that CDK1/2 are involved in EGF-regulated constitutive pre-mRNA splicing in MDA-MB-468 cells.

    Science.gov (United States)

    Chen, Xianwei; Guo, Dan; Zhu, Yinghui; Xian, Feng; Liu, Siqi; Wu, Lin; Lou, Xiaomin

    2016-06-01

    The epidermal growth factor (EGF) receptor (EGFR) pathway is one of the most dysregulated and extensively investigated signaling pathways in human cancers and plays important roles in the regulation of nuclear functions through both cytoplasmic and nuclear EGFR pathways. However, the current understanding of the nuclear phosphorylation responses to activated EGFR pathways remains limited. In the present study, phosphoproteomics analysis revealed the increased phosphorylation of 90 nuclear proteins, primarily involved in RNA processing, pre-mRNA splicing and cell cycle regulation, upon EGF stimulation in MDA-MB-468 cells. Cellular splicing assays of the β-globin (HBB) minigene confirmed that EGF induced constitutive pre-mRNA splicing. Further analysis of phosphoproteomics data identified multiple CDK1/2 substrates in pre-mRNA splicing-related proteins, and both CDK1/2 inhibitors and CDK1/2 knockdowns reduced EGF-regulated pre-mRNA splicing. In conclusion, the results of the present study provide evidence that CDK1/2 participate in the regulation of constitutive pre-mRNA splicing by EGF stimulation in MDA-MB-468 cells. In this study, we successfully carried out a survey of nuclear phosphorylation changes in response to EGF stimulation. The results from the functional category analysis and pre-mRNA splicing assay strongly indicated that EGFR activation increased constitutive pre-mRNA splicing in MDA-MB-468 cells, revealing additional role of EGFR on regulation of mRNA maturation beyond alternative pre-mRNA splicing reported by previous studies. Furthermore, we found that CDK1/2 participated in constitutive pre-mRNA splicing regulation by EGF in MDA-MB-468 cells. Our study provides new knowledge for understanding the regulation of constitutive pre-mRNA splicing by EGF stimulation. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. The Hamiltonian H = xp and Classification of osp(1|2) Representations

    Science.gov (United States)

    Regniers, G.; Van der Jeugt, J.

    2010-06-01

    The quantization of the simple one-dimensional Hamiltonian H = xp is of interest for its mathematical properties rather than for its physical relevance. In fact, the Berry-Keating conjecture speculates that a proper quantization of H = xp could yield a relation with the Riemann hypothesis. Motivated by this, we study the so-called Wigner quantization of H = xp, which relates the problem to representations of the Lie superalgebra osp(1|2). In order to know how the relevant operators act in representation spaces of osp(1|2), we study all unitary, irreducible *-representations of this Lie superalgebra. Such a classification has already been made by J.W.B. Hughes, but we reexamine this classification using elementary arguments.

  4. Second-Order Conformally Equivariant Quantization in Dimension 1|2

    Directory of Open Access Journals (Sweden)

    Najla Mellouli

    2009-12-01

    Full Text Available This paper is the next step of an ambitious program to develop conformally equivariant quantization on supermanifolds. This problem was considered so far in (superdimensions 1 and 1|1. We will show that the case of several odd variables is much more difficult. We consider the supercircle S^{1|2} equipped with the standard contact structure. The conformal Lie superalgebra K(2 of contact vector fields on S^{1|2} contains the Lie superalgebra osp(2|2. We study the spaces of linear differential operators on the spaces of weighted densities as modules over osp(2|2. We prove that, in the non-resonant case, the spaces of second order differential operators are isomorphic to the corresponding spaces of symbols as osp(2|2-modules. We also prove that the conformal equivariant quantization map is unique and calculate its explicit formula.

  5. Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells.

    Science.gov (United States)

    Li, Ai-Ying; Han, Mei; Zheng, Bin; Wen, Jin-Kun

    2008-01-23

    Roscovitine is a potent CDK inhibitor often used as a biological tool in cell-cycle studies, but its working mechanism and real targets in vascular smooth muscle cells (VSMCs) remain unclear. In this study, we observed that ERK1/2 phosphorylation induced by Ang II was abrogated by pretreating VSMCs with roscovitine for 15h. Pretreating VSMCs with roscovitine also inhibited Ang II-induced c-Jun expression and phosphorylation. We further demonstrated that roscovitine could suppress the DNA binding activity of c-Jun and activation of angiotensinogen promoter by Ang II. These results suggest that roscovitine represses Ang II-induced angiotensinogen expression by inhibiting activation of ERK1/2 and c-Jun.

  6. Antitumor activity of platinum(II) complexes of 1,2-diamino-cyclohexane isomers.

    Science.gov (United States)

    Kidani, Y; Noji, M; Tashiro, T

    1980-10-01

    Dichloro, dibromo, oxalato, malonato, dinitrato, sulfato and mono and bis-(D-glucuronato) platinum(II) complexes of 1,2-diaminocyclohexane (dach) isomers were prepared and tested on L1210 mouse leukemia employing the NCI protocol for evaluation of Pt analogs. A large number of long-term survivors were observed with certain analogs, though the therapeutic indices (optimal dose/minimum effective dose) were not large. Among the analogs tested, the oxalato, malonato, dinitrato and mono-(D-glucuronato) Pt(II) complexes of trans-1,2-diaminocyclohexane were found to be particularly effective. The glucuronato Pt complexes appear to be promising candidates for clinical trial since they have the highest solubility in water.

  7. Steady-state and laser flash photolysis studies of 1-aziridinyl-1,2-dibenzoylalkenes

    Energy Technology Data Exchange (ETDEWEB)

    Barik, R.; Kumar, C.V.; Das, P.K.; George, M.V.

    1985-11-01

    Results of a photochemical study based on product analysis and 337.1-nm laser flash photolysis are reported for several cis- and trans-1,2-dibenzoylethylenes bearing aziridinyl groups at the 1-position. Products isolated from steady-state photolysis suggest facile ring expansions yielding pyrrolines as well as extrusion of alkenes from the aziridine moieties forming nitrene fragments, which subsequently undergo ring closure to give isoxazoles. Laser flash photolysis studies show transient absorption changes, explainable in terms of cis-trans photoisomerization and formation of azomethine ylides. The latter are also observed upon steady-state irradiation of these aziridinyl-1,2-dibenzoylethylenes in an EPA glass at 77 K. 46 references, 4 figures.

  8. Millimeter and submillimeter wave spectroscopy of higher energy conformers of 1,2-propanediol

    Science.gov (United States)

    Zakharenko, O.; Bossa, J.-B.; Lewen, F.; Schlemmer, S.; Müller, H. S. P.

    2017-03-01

    We have performed a study of the millimeter/submillimeter wave spectrum of four higher energy conformers of 1,2-propanediol. The present analysis of rotational transitions carried out in the frequency range 38-400 GHz represents a significant extension of previous microwave work. The new data were combined with previously-measured microwave transitions and fitted using a Watson's S-reduced Hamiltonian. The final fits were within experimental accuracy, and included spectroscopic parameters up to sixth order of angular momentum, for the ground states of the four higher energy conformers following previously studied ones: g‧Ga, gG‧g‧, aGg‧ and g‧Gg. The present analysis provides reliable frequency predictions for astrophysical detection of 1,2-propanediol by radio telescope arrays at millimeter wavelengths.

  9. Conjectures and experiments concerning the moments of $L(1/2,\\chi_d)$

    CERN Document Server

    Alderson, Matthew W

    2011-01-01

    We report on some extensive computations and experiments concerning the moments of quadratic Dirichlet $L$-functions at the critical point. We computed the values of $L(1/2,\\chi_d)$ for $- 5\\times 10^{10} < d < 1.3 \\times 10^{10}$ in order to numerically test conjectures concerning the moments $\\sum_{|d|

  10. Synthesis of propylene carbonate from urea and 1,2-propanediol

    Institute of Scientific and Technical Information of China (English)

    Zhi Wen Gao; Shou Feng Wang; Chun Gu Xia

    2009-01-01

    The production of propylene carbonate(PC)from urea and 1,2-propanediol(PG)was investigated in a batch process.The catalytic performances of zinc chloride and magnesium chloride were investigated for this reaction system.The influences of various operation conditions on the PC yield were explored.In this work,MgCl2 and ZnCl2 showed the excellent catalytic activity toward PC synthesis,and the yields of propylene carbonate reached 96.5% and 92.4%,respectively.The optimum reaction conditions were as follows:ethanol/urea molar ratio of 4,catalyst concentration of 1.5%,reaction temperature of 160 ℃,reaction time of 3 h,respectively.The route from urea and 1,2-propanediol shows advantages,such as mild reaction condition and safe operation.The catalytic system is environmentally benign.

  11. Distinct spin liquids and their transitions in spin-1/2 XXZ kagome antiferromagnets.

    Science.gov (United States)

    He, Yin-Chen; Chen, Yan

    2015-01-23

    By using the density matrix renormalization group approach, we study spin-liquid phases of spin-1/2 XXZ kagome antiferromagnets. We find that the emergence of the spin-liquid phase is independent of the anisotropy of the XXZ interaction. In particular, the two extreme limits-the Ising (a strong S^{z} interaction) and the XY (zero S^{z} interaction)-host the same spin-liquid phases as the isotropic Heisenberg model. Both a time-reversal-invariant spin liquid and a chiral spin liquid with spontaneous time-reversal symmetry breaking are obtained. We show that they evolve continuously into each other by tuning the second- and the third-neighbor interactions. And last, we discuss possible implications of our results for the nature of spin liquid in nearest-neighbor XXZ kagome antiferromagnets, including the nearest-neighbor spin-1/2 kagome antiferromagnetic Heisenberg model.

  12. L1/2 regularization based numerical method for effective reconstruction of bioluminescence tomography

    Science.gov (United States)

    Chen, Xueli; Yang, Defu; Zhang, Qitan; Liang, Jimin

    2014-05-01

    Even though bioluminescence tomography (BLT) exhibits significant potential and wide applications in macroscopic imaging of small animals in vivo, the inverse reconstruction is still a tough problem that has plagued researchers in a related area. The ill-posedness of inverse reconstruction arises from insufficient measurements and modeling errors, so that the inverse reconstruction cannot be solved directly. In this study, an l1/2 regularization based numerical method was developed for effective reconstruction of BLT. In the method, the inverse reconstruction of BLT was constrained into an l1/2 regularization problem, and then the weighted interior-point algorithm (WIPA) was applied to solve the problem through transforming it into obtaining the solution of a series of l1 regularizers. The feasibility and effectiveness of the proposed method were demonstrated with numerical simulations on a digital mouse. Stability verification experiments further illustrated the robustness of the proposed method for different levels of Gaussian noise.

  13. [1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.

    Science.gov (United States)

    Spanò, Virginia; Pennati, Marzia; Parrino, Barbara; Carbone, Anna; Montalbano, Alessandra; Lopergolo, Alessia; Zuco, Valentina; Cominetti, Denis; Diana, Patrizia; Cirrincione, Girolamo; Zaffaroni, Nadia; Barraja, Paola

    2016-11-29

    A series of [1,2]Oxazolo [5,4-e]isoindoles has been synthesized through a versatile and high yielding sequence. All the new structures showed in the (1)HNMR spectra, the typical signal in the 8.34-8.47 ppm attributable to the H-3 of the [1,2]oxazole moiety. Among all derivatives, methoxy benzyl substituents at positions 3 and 4 or/and 5 were very effective in reducing the growth of different tumor cell lines, including diffuse malignant peritoneal mesothelioma (DMPM), an uncommon and rapidly malignancy poorly responsive to available therapeutic options. The most active compound 6j was found to impair tubulin polymerization, cause cell cycle arrest at G2/M phase and induce apoptosis in DMPM cells, making it as a new lead for the discovery of new potent antimitotic drugs.

  14. Blocking Effect and Moments of Inertia of K = 1/2 Rotational Band in 171Yb

    Institute of Scientific and Technical Information of China (English)

    YU Shao-Ying; LIU Yan-Xin; LIU Shu-Xin; HE Xiao-Tao

    2004-01-01

    The K = 1/2 rotational band in 171yb is investigated using the particle number conserving (PNC) method for treating the cranked shell model with monopole and quadrupole pairing interactions. The experimental moments of inertia of 171 Yb [521]1/2 (signature α = +1/2) are reproduced well by the PNC calculation, in which no free parameter is involved. The difference in the contribution to the moment of inertia between protons and neutrons is mainly due to the blocking effect of neutron normal orbitals. The ω variation of the occupation probability of each cranked orbital and the contribution to the moment of inertia from each major shell and from each cranked orbital are investigated.

  15. An Enzyme-based 1:2 Demultiplexer Interfaced with an Electrochemical Actuator.

    Science.gov (United States)

    Fratto, Brian E; Guz, Nataliia; Fallon, Tyler T; Katz, Evgeny

    2016-08-02

    An enzyme-based 1:2 demultiplexer is designed in a flow system composed of three cells where each one is modified with a different enzyme: hexokinase, glucose dehydrogenase and glucose-6-phosphate dehydrogenase. The Input signal activating the biocatalytic cascade is represented by glucose, while the Address signal represented by ATP is responsible for directing the Input signal to one of the output channels, depending on the logic value of the Address. The biomolecular 1:2 demultiplexer is extended to include two electrochemical actuators releasing entrapped DNA molecules in the active output channel. The modular design of the system allows for easy exchange and extension of the functional elements. The present demultiplexer can be easily integrated in various biomolecular logic systems, including different logic gates based on the enzyme- or DNA-based reactions, as well as containing different chemical actuators, for example, with a biomolecular release function.

  16. Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections

    Directory of Open Access Journals (Sweden)

    Andreas F. Haag

    2010-01-01

    Full Text Available Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS, unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.

  17. Spin-1/2 Heisenberg Antiferromagnet on the Spatially Anisotropic Kagome Lattice

    Science.gov (United States)

    Schnyder, Andreas; Starykh, Oleg; Balents, Leon

    2008-03-01

    We study the quasi-one-dimensional limit of the Spin-1/2 quantum antiferromagnet on the Kagome lattice, a model Hamiltonian that might be of relevance for the mineral volborthite [1,2]. The lattice is divided into antiferromagnetic spin-chains (exchange J) that are weakly coupled via intermediate ``dangling'' spins (exchange J'). Using bosonization, renormalization group methods, and current algebra techniques we determine the ground state as a function of J'/J. The case of a strictly one-dimensional Kagome strip is also discussed. [1] Z. Hiroi, M. Hanawa, N. Kobayashi, M. Nohara, Hidenori Takagi, Y. Kato, and M. Takigawa, J. Phys. Soc. Japan 70, 3377 (2001). [2] F. Bert, D. Bono, P. Mendels, F. Ladieu, F. Duc, J.-C. Trumbe, and P. Millet, Phys. Rev. Lett. 95, 087203 (2005).

  18. Polydatin induces bone marrow stromal cells migration by activation of ERK1/2.

    Science.gov (United States)

    Chen, ZhenQiu; Wei, QiuShi; Hong, GuoJu; Chen, Da; Liang, Jiang; He, Wei; Chen, Mei Hui

    2016-08-01

    Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of numerous human diseases. However, the reparative ability of BMSCs is limited by their poor migration. Polydatin, widely used in traditional Chinese remedies, has proven to exert protective effects to BMSCs. However, little is known about its role in BMSCs migration. In this study, we studied the effects of polydatin on rat BMSCs migration using the scratch wound healing and transwell migration assays. Our results showed polydatin could promote BMSCs migration. Further experiments showed activation of ERK 1/2, but not JNK, was required for polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs migration via the ERK 1/2 signaling pathways. Taken together, our results indicate that polydatin might be beneficial for stem cell replacement therapy by improving BMSCs migration.

  19. Ground State Properties of the 1/2 Flux Harper Hamiltonian

    Science.gov (United States)

    Kennedy, Colin; Burton, William Cody; Chung, Woo Chang; Ketterle, Wolfgang

    2015-05-01

    The Harper Hamiltonian describes the motion of charged particles in an applied magnetic field - the spectrum of which exhibits the famed Hofstadter's butterfly. Recent advances in driven optical lattices have made great strides in simulating nontrivial Hamiltonians, such as the Harper model, in the time-averaged sense. We report on the realization of the ground state of bosons in the Harper Hamiltonian for 1/2 flux per plaquette utilizing a tilted two-dimensional lattice with laser assisted tunneling. We detail progress in studying various ground state properties of the 1/2 flux Harper Hamiltonian including ground state degeneracies, gauge-dependent observables, effects of micromotion, adiabatic loading schemes, and emergence and decay of coherence. Additionally, we describe prospects for flux rectification using a period-tripled superlattice and generalizations to three dimensions. MIT-Harvard Center for Ultracold Atoms, Research Laboratory of Electronics, Department of Physics, Massachusetts Institute of Technology.

  20. 1.2-GHz gated single-photon detector with simple filtering

    Science.gov (United States)

    Liu, Junliang; Zhang, Chunfang; Li, Yongfu; Wang, Zuqiang

    2014-10-01

    A 1.2-GHz gated infrared single-photon detector based on InGaAs/InP avalanche photodiode (APD) is designed. The APD is working in Geiger mode, gated by 1.2-GHz pseudo-sine wave signal, cooled by a 4-stage Peltier cooler with fancooling. A group of simple 9th order Bessel LC low-pass filters are used to suppress the transient response of the APD by 60 dB. The typical detection efficiency, dark-count probability and afterpulse probability of the detector were 15.1%, 3.76×10-6 /gate and 1.26%, respectively. The detector is based on commercially available inexpensive devices and can be manufactured easily.

  1. Study of structure-activity relationship in Aurein 1.2 analogs.

    Science.gov (United States)

    Soufian, Safieh; Hassani, Leila

    2011-07-15

    Two new analogs of Aurein 1.2 antimicrobial peptide were synthesized and the antimicrobial activities were investigated. The results showed that the activity of G1R/F3W analog was higher than the native peptide and the F3W analog. Circular dichroism studies also showed that the secondary structure of the F3W was concentration-dependent, whereas, there was no such relationship seen in the case of G1R/F3W analog. It has been proposed that G1R/F3W activity was based on a single mechanism (snorkeling), while Aurein 1.2 and F3W utilized the snorkeling mechanism at low concentrations (0-0.01 mM) and the carpet mechanism at higher concentrations (0.01-0.1 mM). This study suggests that one pay attention to the concentration of biomolecules in peptide-based drug design.

  2. Topological basis associated with B-M-W algebra: Two-spin-1/2 realization

    Science.gov (United States)

    Wang, Gangcheng; Sun, Chunfang; Liu, Bo; Liu, Ying; Zhang, Yan; Xue, Kang

    2015-01-01

    In this letter, we study the two-spin-1/2 realization for the Birman-Murakami-Wenzl (B-M-W) algebra and the corresponding Yang-Baxter R ˘ (θ , ϕ) matrix. Based on the two-spin-1/2 realization for the B-M-W algebra, the three-dimensional topological space, which is spanned by topological basis, is investigated. By means of such topological basis realization, the four-dimensional Yang-Baxter R ˘ (θ , ϕ) can be reduced to Wigner DJ function with J = 1. The entanglement and Berry phase in the spectral parameter space are also explored. The results show that one can obtain a set of entangled basis via Yang-Baxter R ˘ (θ , ϕ) matrix acting on the standard basis, and the entanglement degree is maximum when the R˘i (θ , ϕ) turns to the braiding operator.

  3. Elusive 2H-1,2-oxasiletes through reactions of an isolable dialkylsilylene with diazocarbonyl compounds.

    Science.gov (United States)

    Dong, Zhaowen; Xiao, Xu-Qiong; Li, Zhifang; Lu, Qiong; Lai, Guoqiao; Kira, Mitsuo

    2015-09-28

    The reactions of isolable dialkysilylene 1 with 2-diazo-1,2-diphenylethanone and ethyl 2-diazo-2-phenylacetate gave elusive silacycles, 2H-1,2-oxasiletes 2 and 3, respectively, in high yields. Because these reactions occur at low temperatures of ca.-30 °C, initial complexation of the silylene to the carbonyl oxygen of the diazocarbonyl compounds is suggested to trigger dinitrogen elimination followed by cyclization. In contrast, a six-membered cyclic diazo compound 8 and 1-sila-2,3-diazabicyclo[3.3.0]oct-3-ene 10 were obtained in good yields by the reaction of 1 with less reactive ethyl 2-diazo-3-oxo-3-phenylpropanoate 7 and trimethylsilyldiazomethane 9. Molecular structures of 2, 3, 8 and 10 were determined by X-ray crystallography.

  4. The (poetic rhetoric of wisdom in Proverbs 3:1-12

    Directory of Open Access Journals (Sweden)

    J.H. Potgieter

    2002-11-01

    Full Text Available Proverbs 3:1-12 is a masterful example of Hebrew poetry. Failure to consider its poetic structure, is likely to result in incomplete and even incorrect interpretation. Many recent commentaries on Proverbs recognize the poetic character of the book, and even include a section on the poetic techniques present in the book, but ignore the relevance of these techniques as far as the interpretation of the individual poems and the book in general are concerned. This article argues that a comprehensive analysis of poetic features enhances the exegete’s ability to appreciate the rhetoric of wisdom. An intratextual approach towards Proverbs 3:1-12 provides a framework for the complete interpretation of the text.

  5. 1,2-Bis(imino)acenaphthene complexes of molybdenum and nickel.

    Science.gov (United States)

    Fedushkin, Igor L; Skatova, Alexandra A; Lukoyanov, Anton N; Khvoinova, Nalalie M; Piskunov, Alexander V; Nikipelov, Alexander S; Fukin, Georgy K; Lysenko, Konstantin A; Irran, Elisabeth; Schumann, Herbert

    2009-06-28

    Molybdenum hexacarbonyl reacts with 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (, dpp-BIAN) and 1,2-bis[(trimethylsilyl)imino]acenaphthene (, tms-BIAN) in toluene to produce (dpp-BIAN)Mo(CO)(4) () and (tms-BIAN)Mo(CO)(4) (), respectively. The reaction of [CpNi(CO)](2) with yields (dpp-BIAN)NiCp (). Metathesis between Li(2)(tms-BIAN) and NiCl(2)(dppe) affords the Ni(0) complex (tms-BIAN)Ni(dppe) (). The diamagnetic compounds , and have been characterized by (1)H, (29)Si and (31)P NMR spectroscopy, IR spectroscopy and elemental analysis. The ESR spectrum of the paramagnetic compound indicates the presence of Ni(i) coordinated by Cp and a neutral dpp-BIAN ligand. The molecular structures of have been determined by single-crystal X-ray analysis.

  6. A Convenient Synthesis of Octahydro-pyrazino [ 1,2- a ] pyrazine

    Institute of Scientific and Technical Information of China (English)

    LIANG Feng; WU Xiao-Jun; ZHANG Shi-Wei; WU Cheng-Tai

    2003-01-01

    @@ The recent research results suggest that a series of octahydro-pyrazino[ 1,2-a ]pyrazines are useful as antiallergic agents.[1] Gubert et al. [2] developed a route from 1,4-dibenzyl-2-ethoxycarbonylpiperazine for the synthesis of this ring system. Under their conditions, this ring system was obtained with a low overall yield in six steps. Optimization of synthetic route to this ring system is still desirable. In this paper, we presented an efficient synthesis of octahydropyrazino[1,2-a]pyrazine by a new and efficient method starting from 1,3-dichloro-2-propanol and N-tosylated diethylenetriamine. The structure of title compound was determined by spectroscopy and X-ray diffraction technique.

  7. Straightforward synthesis of 1,2-dicyanoalkanes from nitroalkenes and silyl cyanide mediated by tetrabutylammonium fluoride.

    Science.gov (United States)

    Kiyokawa, Kensuke; Nagata, Takaya; Hayakawa, Junpei; Minakata, Satoshi

    2015-01-12

    A straightforward synthesis of 1,2-dicyanoalkanes by reacting nitroalkenes with trimethylsilyl cyanide in the presence of tetrabutylammonium fluoride is described. The reaction proceeds through a tandem double Michael addition under mild conditions. Employing the hypervalent silicate generated from trimethylsilyl cyanide and tetrabutylammonium fluoride is essential for achieving this transformation. Mechanistic studies suggest that a small amount of water included in the reaction media plays a key role. This protocol is applicable to various types of substrates including electron-rich and electron-deficient aromatic nitroalkenes, and aliphatic nitroalkenes. Moreover, vinyl sulfones were found to be good alternatives, particularly for electron-deficient nitroalkenes. The broad substrate scope and functional group tolerance of the reaction makes this approach a practical method for the synthesis of valuable 1,2-dicyanoalkanes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Bis-(1-2-benzopyran-1-one) derivatives: Synthesis and antimicrobial evaluation

    Indian Academy of Sciences (India)

    Poonam Kumar Koppula; Nalini Purohit

    2013-11-01

    The aim of the present study was to synthesize isocoumarin heterocycles and to elucidate the potential role of these compounds as biological active agents. A new series of isocoumarin derivatives containing two six-membered lactone rings is reported. 3-Aroyl-substituted isocoumarins (3) obtained by condensing 2-carboxy benzaldehyde (1) with bromoacetophenone derivatives (2) was further reacted with different aromatic aldehydes (4) affording bis-(1-2-benzopyran-1-one) derivatives (5). This short review compiles examples of most promising antibacterial, antifungal and analgesic bis-(1H-2-benzopyran-1-one) derivatives. The products were characterized on the basis of analytical and spectral (IR, 1HNMR, C13NMR, Mass) data. The biological activity study revealed that all compounds showed promising activities and bis-(1-2-benzopyran-1-one) derivatives (5) were found to be more active than 3-aroyl-substituted isocoumarins (3).

  9. Chiral trans-1,2-diaminocyclohexane derivatives as chiral solvating agents for carboxylic acids

    Indian Academy of Sciences (India)

    Mariappan Periasamy; Manasi Dalai; Meduri Padmaja

    2010-07-01

    Efficient use of the readily accessible chiral 2-symmetric acyclic diamines (1-2) as well as macrocyclic amines (3-5) containing trans-1,2-diaminocyclohexyl moiety as chiral solvating agents (CSA) for the determination of enantiomeric excess of representative carboxylic acids (6-7) and an amino acid derivative (8) is illustrated. The enantiomeric composition of different carboxylic acids estimated here by the 1H NMR method, based on the integration of the corresponding methine proton signals are in good correlation with that determined using HPLC method. The data are in accordance with the formation of multimolecular diastereomeric complexes in solution, which render good splitting of NMR signals for the enantiomers of representative carboxylic acids as well as for -Ts-phenylglycine (up to = 0.295 ppm, 118 Hz).

  10. Universal spin-1/2 fermion field localization on a 5D braneworld

    CERN Document Server

    Barbosa-Cendejas, Nandinii; Mora-Luna, Refugio Rigel

    2015-01-01

    In this work we present a refined method for the localization of spin-$\\frac{1}{2}$ fermions on the 5D braneworld paradigm. We begin by proposing a more natural ansatz for the Yukawa coupling in the 5D bulk fermionic action, that guarantees the localization of the ground states for the 4D fermions with right or left chirality. Furthermore, we show that the fermion ground states localization allow us to show the absence of tachyonic modes in the left and right-chiral Kaluza-Klein mass spectrum. More precisely, we show that localization of gravity in the 5D braneworld implies the localization of the spin-$\\frac{1}{2}$ fermions.

  11. Formation of Polyhydroxyalkanoate Blends by Pseudomonas pseudoalcaligenes M1-2 from Various Carbon Sources

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Pseudomonas pseudoalcaligenes strain M1-2 isolated from oil-contaminated soil collected from an oilfield in northern China was found to be able to synthesize a blend of polyhydroxyalkanoates (PHAs) containing monomers of 3-hydroxybutyrate (C4), 3-hydroxyvalerate (C5), 3-hydroxyheptanoate (C7), 3-hydroxyoctanoate (C8), 3-hydroxynonanoate (C9), 3-hydroxydecanoate (C10) and 3-hydroxydodecanoate (C12) from various carbon sources.The hydroxyalkanoate (HA) monomer composition varied both quantitatively and qualitatively, depending on the carbon sources used.The presence of octanoate in substrates of myristic acid or tridecanoate promoted the synthesis of HB monomer in the blend.Concentration of octanoate was also found to significantly affect the PHB content in the blend.A PHA biosynthesis pathway in Pseudomonas pseudoalcaligens M1-2 was proposed.

  12. Dichloridobis(2-methoxydibenzo[c,e][1,2]oxaphosphorine-κPplatinum(II trichloromethane solvate

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available The title compound, [PtCl2(C13H11O2P2]·CHCl3, has a rare PtCl2 bridging of two dibenzooxaphosphorine ligands through the metal atom. The PtII ion is in a slightly distorted square-planar environment. The trichloromethane solvent molecule shows rotational disorder (major occupancy is 0.75 and is placed near to the inversion centre at (1/2, 1/2, 0 in channels parallel to the a axis. The solvent molecule is linked to the complex molecule via intermolecular bifurcated C—H...Cl and C—H...O hydrogen bonds. The crystal structure is further stabilized by π–π interactions involving the benzene rings, with a centroid–centroid distance of 3.658 (8 Å.

  13. On group properties and reality conditions of UOSp(1|2) gauge transformations

    CERN Document Server

    Ilyenko, Kostyantyn

    2008-01-01

    For osp(1|2;C) graded Lie algebra, which proper Lie subalgebra is su(2), we consider the Baker-Campbell-Hausdorff formula and formulate a reality condition for the Grassmann-odd transformation parameters that multiply the pair of odd generators of the graded Lie algebra. Utilization of su(2)-spinors clarifies the nature of Grassmann-odd transformation parameters and allow us an investigation of the corresponding infinitesimal gauge transformations. We also explore action of the corresponding group element of UOSp(1|2) on an appropriately graded representation space and find that the graded generalization of hermitian conjugation is compatible with the Dirac adjoint. Consistency of generalized (graded) unitary condition with the proposed reality condition is shown.

  14. Initial nonresponse and survey response mode biases in survey research.

    Science.gov (United States)

    Chi, Donald L; Chen, Chao Ying

    2015-01-01

    We evaluated survey response factors (particularly initial nonresponse and survey mode) that may be associated with bias in survey research. We examined prevention-related beliefs and outcomes for initial mail survey responders (n=209), follow-up mail survey responders (n=78), and follow-up telephone survey responders (n=74). The Pearson chi-square test and analysis of variance identified beliefs and behavioral outcomes associated with survey response mode. Follow-up options to the initial mail survey improved response rates (22.0-38.0 percent). Initial mail survey responders more strongly believed topical fluoride protects teeth from cavities than others (P=0.04). A significantly larger proportion of parents completing a follow-up telephone survey (30.8 percent) refused topical fluoride for their child than those completing mail surveys (10.3-10.4 percent) (Psurveys with follow-up improve response rates. Initial nonresponse and survey response mode may be associated with biases in survey research. © 2015 American Association of Public Health Dentistry.

  15. Bis(μ-3-carboxy-2-hydroxypropane-1,2-dicarboxylatobis(diaquazinc–1,2-bis(pyridin-4-ylethene–water (1/1/2

    Directory of Open Access Journals (Sweden)

    In Hong Hwang

    2012-10-01

    Full Text Available The asymmetric unit of the title compound, [Zn2(C6H6O72(H2O4]·C12H10N2·2H2O, comprises half of a centrosymmetric complex dimer, half of a 1,2-bis(pyridin-4-ylethene molecule, which lies across an inversion centre, and one lattice water molecule. Carboxylate groups of two dianionic citrate ligands bridge two ZnII ions to give the cyclic dimer, with each ZnII ion coordinated by four O atoms from the chelating citrate ligand (one hydroxy and three carboxylate, with one bridging and two water O atoms, forming a distorted octahedral environment [Zn—O = 2.040 (3–2.244 (3 Å]. In the crystal, O—H...O and O—H...N hydrogen bonds involving hydroxy groups and both coordinating and lattice water molecules link the dimers to give a three-dimensional framework structure.

  16. Refractive errors in infancy predict reduced performance on the movement assessment battery for children at 3 1/2 and 5 1/2 years.

    Science.gov (United States)

    Atkinson, Janette; Nardini, Marko; Anker, Shirley; Braddick, Oliver; Hughes, Clare; Rae, Sarah

    2005-04-01

    We have previously reported that significant hyperopia at 9 months predicts mild deficits on visuocognitive and visuomotor measures between 2 years and 5 years 6 months. Here we compare the motor skills of children who had been hyperopic in infancy (hyperopic group) with those who had been emmetropic (control group), using the Movement Assessment Battery for Children (Movement ABC). Children were tested at 3 years 6 months (hyperopic group: 47 males, 63 females, mean age 3 y 7 mo, SD 1.6 mo; control group: 61 males, 70 females, mean age 3 y 7 mo, SD 1.2 mo) and at 5 years 6 months (hyperopic group: 43 males, 56 females, mean age 5 y 4 mo, SD 1.7 mo; control group: 51 males, 62 females, mean age 5 y 3 mo, SD 1.6 mo). The hyperopic group performed significantly worse at both ages, overall and on at least one test from each category of motor skill (manual dexterity, balance, and ball skills). Distributions of scores showed that these differences were not due to poor performance by a minority but to a widespread mild deficit in the hyperopic group. This study also provides the first normative data on the Movement ABC for children below 4 years of age, and shows that it provides a useful measure of motor development at this young age.

  17. Removal Salt in 1,2-propanediol by Electrodialysis%用电渗法去除1,2-丙二醇中的无机盐

    Institute of Scientific and Technical Information of China (English)

    盛旭琳; 王丽燕; 钟爱国

    2011-01-01

    It was studied that the membrane voltage, pH, concentration of original solution on the removal of sodium chloride. The result shows that the membrane voltage of 2 V, pH = 7, after 8 hours of desalination, the conductivity of the solution from 15 000 μS/cm down to 200 μS/cm, desalination rate of 98.7%, can basically meet the industrial production requirements.%用电渗法对1,2-丙二醇氯化钠液提纯.研究膜对电压、pH值、原液浓度等条件对其去除氯化钠的影响.结果表明,膜压为2V,pH=7时,经过8小时的电渗脱盐,溶液的电导率可从15 000 μS/cm降到200 μS/cm,脱盐率达到98.7%,能基本满足工业生产要求.

  18. SYNTHESIS AND CHARACTERIZATION OF HIGH MOLECULAR WEIGHT POLY(1,2-PROPYLENE CARBONATE-co-1,2-CYCLOHEXYLENE CARBONATE)USING ZINC COMPLEX CATALYST

    Institute of Scientific and Technical Information of China (English)

    Jing-shu Wu; Min Xiao; Hu He; Shuan-jin Wang; Dong-mei Han; Yue-zhong Meng

    2011-01-01

    Using supported multi-component zinc dicarboxylate catalyst,poly(1,2-propylene carbonate-co-l,2-cyclohexylene carbonate) (PPCHC) was successfully synthesized from carbon dioxide (CO2) with propylene oxide (PO) and cyclohexene oxide (CHO).The conversion of epoxides dramatically increased up to 89.7% (yield:384.2 g of polymer per g of Zn) with increasing reaction temperature from 60℃ to 80℃.The optimized reaction temperature is 80℃.The chemical structure,the molecular weight,as well as thermal and mechanical properties of the resulting terpolymers were investigated extensively.When CHO feed content (mol%) is lower than 10%,the PPCHC terpolymers have number average molecular weight (Mn)ranging from 102 × 103 to 202 × 103 and molecular weight distribution (MWD) values ranging from 2.8 to 3.5.In contrast to poly(propylene carbonate) (PPC),the introduction of small amount of CHO leads to increase in the glass transition temperature from 38.0℃ to 42.6℃.Similarly,the mechanical strength of the synthesized terpolymer is greatly enhanced due to the incorporation of CHO.These improvements in mechanical and thermal properties are of importance for the practical application of PPC.

  19. One hundred percent orange juice consumption is associated with better diet quality, improved nutient adequacy, and no increased risk for overweight/obesity in children

    Science.gov (United States)

    The purpose of this study was to examine the association of 100 percent orange juice consumption by children 2 to 18 years of age (n = 7250) participating in the 2003 to 2006 National Health and Nutrition Examination Survey with intakes of select nutrients, MyPyramid food groups, diet quality-measur...

  20. Synthesis, Photochromic Kinetics, Fluorescence and Structure of a New 1,2-Diarylcyclopentene

    Institute of Scientific and Technical Information of China (English)

    PU ,Shou-Zhi; XIAO, Qiang; XU, Jing-Kun; SHEN, Liang; LI, Gui-Zhen; CHEN, Bing

    2006-01-01

    The photochromic diarylethene, 1,2-bis[2-methyl-5-(3-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene(BMTTP), was synthesized and its photochromic kinetics, fluorescence and X-ray structure were investigated. This compound underwent a photochromic reaction both in solution and the single crystalline phase. Its cyclization/cycloreversion process was determined to be zeroth/first order reaction, respectively, and this is the first report on the cyclization/cycloreversion reaction order. In addition, its fluorescence property was also discussed.