WorldWideScience

Sample records for super fixed target

  1. CERN's Fixed Target Primary Ion Programme

    CERN Document Server

    Manglunki, Django; Axensalva, Jerome; Bellodi, Giulia; Blas, Alfred; Bodendorfer, Michael; Bohl, Thomas; Cettour-Cave, Stephane; Cornelis, Karel; Damerau, Heiko; Efthymiopoulos, Ilias; Fabich, Adrian; Ferreira Somoza, Jose; Findlay, Alan; Freyermuth, Pierre; Gilardoni, Simone; Hancock, Steven; Holzer, Eva Barbara; Jensen, Steen; Kain, Verena; Küchler, Detlef; Lombardi, Alessandra; Michet, Alice; O'Neil, Michael; Pasinelli, Sergio; Scrivens, Richard; Steerenberg, Rende; Tranquille, Gerard

    2016-01-01

    The renewed availability of heavy ions at CERN for the needs of the LHC programme has triggered the interest of the fixed-target community. The project, which involves sending several species of primary ions at various energies to the North Area of the Super Proton Synchrotron, has now entered its operational phase. The first argon run, with momenta ranging from 13 AGeV/c to 150 AGeV/c, took place from February 2015 to April 2015. This paper presents the status of the project, the performance achieved thus far and an outlook on future plans.

  2. Fixed Target Collisions at STAR

    Science.gov (United States)

    Meehan, Kathryn C.

    2016-12-01

    The RHIC Beam Energy Scan (BES) program was proposed to look for the turn-off of signatures of the quark gluon plasma (QGP), search for a possible QCD critical point, and study the nature of the phase transition between hadronic and partonic matter. Previous results have been used to claim that the onset of deconfinement occurs at a center-of-mass energy of 7 GeV. Data from lower energies are needed to test if this onset occurs. The goal of the STAR Fixed-Target Program is to extend the collision energy range in BES II to energies that are likely below the onset of deconfinement. Currently, STAR has inserted a gold target into the beam pipe and conducted test runs at center-of-mass energies of 3.9 and 4.5 GeV. Tests have been done with both Au and Al beams. First physics results from a Coulomb potential analysis of Au + Au fixed-target collisions are presented and are found to be consistent with results from previous experiments. Furthermore, the Coulomb potential, which is sensitive to the Z of the projectile and degree of baryonic stopping, will be compared to published results from the AGS.

  3. Fixed target facility at the SSC

    Energy Technology Data Exchange (ETDEWEB)

    Loken, S.C.; Morfin, J.G.

    1985-01-01

    The question of whether a facility for fixed target physics should be provided at the SSC must be answered before the final technical design of the SSC can be completed, particularly if the eventual form of extraction would influence the magnet design. To this end, an enthusiastic group of experimentalists, theoreticians and accelerator specialists have studied this point. The accelerator physics issues were addressed by a group led by E. Colton whose report is contained in these proceedings. The physics addressable by fixed target was considered by many of the Physics area working groups and in particular by the Structure Function Group. This report is the summary of the working group which considered various SSC fixed target experiments and determined which types of beams and detectors would be required. 13 references, 5 figures.

  4. Fixed-target physics at LHCb

    CERN Document Server

    Maurice, Emilie Amandine

    2017-01-01

    The LHCb experiment has the unique possibility, among the LHC experiments, to be operated in fixed target mode, using its internal gas target SMOG. The energy scale achievable at the LHC and the excellent detector capabilities for vertexing, tracking and particle identification allow a wealth of measurements of great interest for cosmic ray and heavy ions physics. We report the first measurements made in this configuration: the measurement of antiproton production in proton-helium collisions and the measurements of open and hidden charm production in proton-argon collisions at $\\sqrt{s_\\textrm{NN}} =$ 110 GeV.

  5. Super-FRS Target Area Remote Handling: Scenario and Development

    Directory of Open Access Journals (Sweden)

    Luis Miguel Orona

    2013-11-01

    Full Text Available The Super-FRS, Superconducting Fragment Separator, is a unique machine that presents several challenging technical problems. One of these is regarding how to conduct maintenance in the target area where high levels of radiation will be generated and human access is forbidden. To address this problem the use of a remote maintenance system is foreseen. The objective of this paper is to develop a systems engineering (SE research and development (R&D approach suitable to develop the Super-FRS Target Area Remote Maintenance Systems (TARMS and the RH design adaptation of the components in the target area. The Super-FRS target area is described in detail in order to introduce the need for a remote maintenance system. Components in the target area are classified by adopting ITER RH maintenance classification. The general scenario of remote handling and the current target area remote maintenance system are described. Finally, the proposed systems engineering approach is presented.

  6. Fixed target experiments at the Fermilab Tevatron

    CERN Document Server

    Gutierrez, Gaston

    2014-01-01

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of $\\sqrt{s}=40$ GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include $\\pi^+\\pi^-$, $K^0_s K^0_s$, $ K^0_sK^\\pm\\pi^\\mp$, $\\phi\\phi$ and $D^{*\\pm}$. Partial Wave Analysis results will be presented on the light states but only the cross section will be reviewed in the diffractive production of $D^{*\\pm}$

  7. Layout of the Super-FRS target hall

    Science.gov (United States)

    Kozlova, E.; Weick, H.; Achenbach, B.; Behr, K.-H.; Fehrenbacher, G.; Geissel, H.; Gleim, M.; Karagiannis, C.; Kelic, A.; Kratz, A.; Radon, T.; Sümmerer, K.; Winkler, M.

    2008-10-01

    The fragment separator Super-FRS is an important part of the planned international facility for antiproton and ion research (FAIR). The high intensity heavy ion beams with a beam power of up to 40 kW for uranium require strong shielding of the area and safe handling of the components in the beamline. As the primary beam may be dumped at many positions along the separator the whole first part of the Super-FRS will be located in a dedicated target hall. The layout of this target hall is presented in this paper. The combination of iron and concrete for the biological shielding is determined by dose rate calculations with a radiation transport code (FLUKA) which can also treat heavy ions and predict dose rates after activation. The resulting layout foresees a compact iron shielding surrounded by many meters of concrete shielding. A plug system is used to insert devices into the beamline. A crane can transport these plugs to a nearby hot cell. The thickness of the inner shielding was adjusted to reduce the calculated dose rate on a working platform after a short waiting time to enable hands-on maintenance. Very important for the handling concept is the predicted activation of the devices inserted into the beam and of the shielding material itself.

  8. Super-light SL-Deck elements with fixed end connections

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl

    2015-01-01

    to low weight and due to possibilities of continuous elements and fixed end connections. A new machine is constructed producing the elements and BIM software is developed optimizing the structures, the production, and the logistics and running the machine. New production lines are established......Super-light structures combining light and strong concrete are invented by the author at the Technical University of Denmark and commercialized by the spin-out company Abeo Ltd. The first product is the SL-Deck element that represents a number of strong improvements to the building industry among...... which improved sound insulation, low weight, low CO2 emission, 4 hour fire resistance, improved flexibility with respect to holes, services, curved edges, conical shapes, cross-reinforcements, included beams and edge stringers, balcony solutions, hung down elements, leaf-connections, and long spans due...

  9. Light Dilaton at Fixed Points and Ultra Light Scale Super Yang Mills

    DEFF Research Database (Denmark)

    Antipin, Oleg; Mojaza, Matin; Sannino, Francesco

    2012-01-01

    We investigate the infrared dynamics of a nonsupersymmetric SU(X) gauge theory featuring an adjoint fermion, Nf Dirac flavors and an Higgs-like complex Nf x Nf scalar which is a gauge singlet. We first establish the existence of an infrared stable perturbative fixed point and then investigate...... the spectrum near this point. We demonstrate that this theory naturally features a light scalar degree of freedom to be identified with the dilaton and elucidate its physical properties. We compute the spectrum and demonstrate that at low energy the nonperturbative part of the spectrum of the theory is the one...... of pure supersymmetric Yang-Mills. We can therefore determine the exact nonperturbative fermion condensate and deduce relevant properties of the nonperturbative spectrum of the theory. We also show that the intrinsic scale of super Yang-Mills is exponentially smaller than the scale associated...

  10. Preparation of a primary argon beam for the CERN fixed target physics.

    Science.gov (United States)

    Küchler, D; O'Neil, M; Scrivens, R; Thomae, R

    2014-02-01

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar(11+) beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  11. Preparation of a primary argon beam for the CERN fixed target physics

    Energy Technology Data Exchange (ETDEWEB)

    Küchler, D., E-mail: detlef.kuchler@cern.ch; O’Neil, M.; Scrivens, R. [CERN, BE Department, 1211 Geneva 23 (Switzerland); Thomae, R. [iThemba LABS, P.O. Box 722, Somerset West 7130 (South Africa)

    2014-02-15

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar{sup 11+} beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  12. Beauty, charm and hyperon production at fixed-target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Erik Gottschalk

    2002-12-11

    Over the years fixed-target experiments have performed numerous studies of particle production in strong interactions. The experiments have been performed with different types of beam particles of varying energies, and many different target materials. Since the physics of particle production is still not understood, ongoing research of phenomena that we observe as beauty, charm and strange-particle production is crucial if we are to gain an understanding of these fundamental processes. It is in this context that recent results from fixed-target experiments on beauty, charm, and hyperon production will be reviewed.

  13. Event Display for the Fixed Target Experiment BM@N

    Directory of Open Access Journals (Sweden)

    Gertsenberger Konstantin

    2016-01-01

    Full Text Available One of the main problems to be solved in modern high energy physics experiments on particle collisions with a fixed target is the visual representation of the events during the experiment run. The article briefly describes the structure of the BM@N facility at the Nuclotron being under construction at the Joint Institute for Nuclear Research with the aim to study properties of the baryonic matter in collisions of ions with fixed target at energies up to 4 GeV/nucleon (for Au79+. Aspects concerning the visualization of data and detector details at the modern experiments and possibilities of practical applications are discussed. We present event display system intended to visualize the detector geometries and events of particle collisions with the fixed target, its options and features as well as integration with BMNRoot software. The examples of graphical representation of simulated and reconstructed points and particle tracks with BM@N geometry are given for central collisions of Au79+ ions with gold target and deuterons with carbon target.

  14. Event Display for the Fixed Target Experiment BM@N

    Science.gov (United States)

    Gertsenberger, Konstantin

    2016-02-01

    One of the main problems to be solved in modern high energy physics experiments on particle collisions with a fixed target is the visual representation of the events during the experiment run. The article briefly describes the structure of the BM@N facility at the Nuclotron being under construction at the Joint Institute for Nuclear Research with the aim to study properties of the baryonic matter in collisions of ions with fixed target at energies up to 4 GeV/nucleon (for Au79+). Aspects concerning the visualization of data and detector details at the modern experiments and possibilities of practical applications are discussed. We present event display system intended to visualize the detector geometries and events of particle collisions with the fixed target, its options and features as well as integration with BMNRoot software. The examples of graphical representation of simulated and reconstructed points and particle tracks with BM@N geometry are given for central collisions of Au79+ ions with gold target and deuterons with carbon target.

  15. Testing Light Dark Matter Coannihilation With Fixed-Target Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Izaguirre, Eder [Brookhaven Natl. Lab.; Kahn, Yonatan [Princeton U.; Krnjaic, Gordan [Fermilab; Moschella, Matthew [Princeton U.

    2017-03-20

    In this paper, we introduce a novel program of fixed-target searches for thermal-origin Dark Matter (DM), which couples inelastically to the Standard Model. Since the DM only interacts by transitioning to a heavier state, freeze-out proceeds via coannihilation and the unstable heavier state is depleted at later times. For sufficiently large mass splittings, direct detection is kinematically forbidden and indirect detection is impossible, so this scenario can only be tested with accelerators. Here we propose new searches at proton and electron beam fixed-target experiments to probe sub-GeV coannihilation, exploiting the distinctive signals of up- and down-scattering as well as decay of the excited state inside the detector volume. We focus on a representative model in which DM is a pseudo-Dirac fermion coupled to a hidden gauge field (dark photon), which kinetically mixes with the visible photon. We define theoretical targets in this framework and determine the existing bounds by reanalyzing results from previous experiments. We find that LSND, E137, and BaBar data already place strong constraints on the parameter space consistent with a thermal freeze-out origin, and that future searches at Belle II and MiniBooNE, as well as recently-proposed fixed-target experiments such as LDMX and BDX, can cover nearly all remaining gaps. We also briefly comment on the discovery potential for proposed beam dump and neutrino experiments which operate at much higher beam energies.

  16. A new Mtest beamline for the 1999 fixed target run

    Energy Technology Data Exchange (ETDEWEB)

    C. N. Brown and T. R. Kobilarcik

    2000-05-18

    The beamline cryogenic system for the Meson area will not be run for the 1999 fixed target run. The current MTest (MT) beamline relies on cryogenic magnets. A non-cryogenic solution is proposed which can yield up to 1 x 10{sup 6} pions per cycle at 120 GeV/c per 1 x 10{sup 11} incident protons at 800 GeV/c.

  17. Fixed-target physics at LHCb arXiv

    CERN Document Server

    Maurice, Emilie

    The LHCb experiment has the unique possibility, among the LHC experiments, to be operated in fixed target mode, using its internal gas target SMOG. The energy scale achievable at the LHC and the excellent detector capabilities for vertexing, tracking and particle identification allow a wealth of measurements of great interest for cosmic ray and heavy ions physics. We report the first measurements made in this configuration: the measurement of antiproton production in proton-helium collisions and the measurements of open and hidden charm production in proton-argon collisions at $\\sqrt{s_\\textrm{NN}} =$ 110 GeV.

  18. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Science.gov (United States)

    2010-10-01

    ... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor), and...

  19. In celebration of the fixed target program with the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey A. Appel et al.

    2001-12-28

    The Tevatron is the world's first large superconducting accelerator. With its construction, we gained the dual opportunities to advance the state of the art in accelerator technology with the machine itself and in particle physics with the experiments that became possible in a higher energy regime. There have been 43 experiments in the Tevatron fixed target program. Many of these are better described as experimental programs, each with a broad range of physics goals and results, and more than 100 collaborating physicists and engineers. The results of this program are three-fold: (1) new technologies in accelerators, beams and detectors which advanced the state of the art; (2) new experimental results published in the refereed physics journals; and (3) newly trained scientists who are both the next generation of particle physicists and an important part of the scientific, technical and educational backbone of the country as a whole. In this book they compile these results. There are sections from each experiment including what their physics goals and results were, what papers were published, and which students have received degrees. Summaries of these results from the program as a whole are quite interesting, but the physics results from this program are too broad to summarize globally. The most important of the results appear in later sections of this booklet.

  20. High-Efficiency Retrofit Lessons for Retail from a SuperTarget: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Langner, R.; Deru, M.; Hirsch, A.; Williams, S.

    2013-02-01

    The National Renewable Energy Laboratory partnered with Target under the Commercial Building Program to design and implement a retrofit of a SuperTarget in Thornton, CO. The result was a retrofit design that predicted 37% energy savings over ASHRAE Standard 90.1-2004, and 29% compared to existing (pre-retrofit) store consumption. The largest savings came from energy efficient lighting, energy efficient cooling systems, improved refrigeration, and better control of plug loads.

  1. Probable projectile-target combinations for the synthesis of super heavy nucleus $^{286}$112

    CERN Document Server

    Santhosh, K P

    2014-01-01

    The fusion cross sections for the reactions of all the projectile-target combinations found in the cold valleys of $^{286}$112 have been studied using scattering potential as the sum of Coulomb and proximity potential, so as to predict the most probable projectile-target combinations in heavy ion fusion reactions for the synthesis of super heavy nucleus $^{286}$112. While considering the nature of potential pockets and half lives of the colliding nuclei, the systems $^{82}$Ge + $^{204}$Hg, $^{80}$Ge + $^{206}$Hg and $^{78}$Zn + $^{208}$Pb found in the deep cold valley region and the systems $^{48}$Ca+$^{238}$U, $^{38}$S+$^{248}$Cm and $^{44}$Ar+$^{242}$Pu in the cold valleys are predicted to be the better optimal projectile-target combinations for the synthesis of super heavy nucleus $^{286}$112.

  2. Probable Projectile-Target Combinations for the Synthesis of Super Heavy Nucleus 286112

    Directory of Open Access Journals (Sweden)

    K. P. Santhosh

    2014-02-01

    Full Text Available The fusion cross sections for the reactions of all the projectile-target combinations found in the cold valleys of 286112 have been studied using scattering potential as the sum of Coulomb and proximity potential, so as to predict the most probable projectile-target combinations in heavy ion fusion reactions for the synthesis of super heavy nucleus 286112. While considering the nature of potential pockets and half lives of the colliding nuclei, the systems 82Ge + 204Hg, 80Ge + 206Hg and 78Zn + 208Pb found in the deep cold valley region and the systems 48Ca+238U, 38S+248Cm and 44Ar+242Pu in the cold valleys are predicted to be the better optimal projectile-target combinations for the synthesis of super heavy nucleus 286112.

  3. Estimation of critical parameters for the Super-FRS target at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Meister, Claudia-Veronika; Hoffmann, Dieter H.H. [Technische Universitaet Darmstadt, Institut fuer Kernphysik (Germany)

    2014-07-01

    In the Super-FRS target and in the beam catchers at GSI stress waves are generated by intense, fast-extracted ion beams which deposit a high amount of energy within a very short time into target material. This may cause material damage. In this connection, measurements of thermal parameters and eddy-currents resistivity are planned as monitoring techniques. At the same time, to understand the physics of the destruction processes in more detail, also a comprehensive theoretical study of thermal parameters such as heat capacity and coefficient of thermal expansion as well as transport coefficients in warm dense matter is necessary. Here, latest experimental and theoretical results for the critical parameters of the Super-FRS target are compared.

  4. An Optimization of Super-Miniature X-ray Target

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Jin; Heo, Sung Hwan; Ha, Jun Mok; Cho, Sung Oh [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2011-05-15

    Electronic brachytherapy is now becoming popular because it has certain advantages over the radionuclide based brachytherapy sources. Unlike radionuclide based source, electronic brachytherapy system generates radiation using an X-ray tube. In case of radionuclide-based source, radiation is always produced regardless of needs. But X-ray produced from electronic brachytherapy system can be turned on and off thus we can get only the desired X-ray. Secondly, the dose rate can be easily controlled by adjusting operating voltage and current of electronic brachytherapy system. Lastly, electronic brachytherapy system precludes the hazards of handling the radioactive source. When we use the radiation for brachytherapy or intra-cavity imaging, one of the important concerns is the uniformity of X-ray dose distribution. Dose distribution from electronic brachytherapy system is determined by structure and geometry of X-ray target

  5. Is there a role for fixed target heavy ion physics beyond RHIC startup?

    Energy Technology Data Exchange (ETDEWEB)

    Sandweiss, J. [Yale Univ., New Haven, CT (United States)

    1995-07-15

    The interesting and important physics opportunities provided by AGS and CERN fixed target facilities will be far from exhausted by the time of RHIC turn on. Given the need for the AGS to provide heavy ion beams for injection into RHIC, the cost effectiveness of fixed target experimentation with AGS beams will be high. Examples of the physics are given.

  6. Renaissance of the ~ 1-TeV Fixed-Target Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T.; /Florida State U.; Appel, J.A.; /Fermilab; Arms, K.E.; /Minnesota U.; Balantekin, A.B.; /Wisconsin U., Madison; Conrad, J.M.; /MIT; Cooper, P.S.; /Fermilab; Djurcic, Z.; /Columbia U.; Dunwoodie, W.; /SLAC; Engelfried, J.; /San Luis Potosi U.; Fisher, P.H.; /MIT; Gottschalk, Erik Edward; /Fermilab; de Gouvea, A.; /Northwestern U.; Heller, K.; /Minnesota U.; Ignarra, C.M.; Karagiorgi, G.; /MIT; Kwan, S.; /Fermilab; Loinaz, W.A.; /Amherst Coll.; Meadows, B.; /Cincinnati U.; Moore, R.; Morfin, J.G.; /Fermilab; Naples, D.; /Pittsburgh U. /St. Mary' s Coll., Minnesota /New Mexico State U. /Michigan U. /Wayne State U. /South Carolina U. /Florida U. /Carnegie Mellon U. /Cincinnati U. /Columbia U. /Columbia U. /Northwestern U. /Yale U. /Fermilab /Argonne /Northwestern U. /APC, Paris

    2011-12-02

    This document describes the physics potential of a new fixed-target program based on a {approx}1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  7. Renaissance of the ~1 TeV Fixed-Target Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T.; /Florida State U.; Appel, Jeffrey A.; /Fermilab; Arms, Kregg Elliott; /Minnesota U.; Balantekin, A.B.; /Wisconsin U., Madison; Conrad, Janet Marie; /MIT; Cooper, Peter S.; /Fermilab; Djurcic, Zelimir; /Columbia U.; Dunwoodie, William M.; /SLAC; Engelfried, Jurgen; /San Luis Potosi U.; Fisher, Peter H.; /MIT; Gottschalk, E.; /Fermilab /Northwestern U.

    2009-05-01

    This document describes the physics potential of a new fixed-target program based on a {approx} TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  8. Prospectives for A Fixed-Target ExpeRiment at the LHC: AFTER@LHC

    CERN Document Server

    Lansberg, J P; Didelez, J P; Genolini, B; Hadjidakis, C; Lorce, C; Rosier, P; Anselmino, M; Arnaldi, R; Scomparin, E; Brodsky, S J; Ferreiro, E G; Fleuret, F; Rakotozafindrabe, A; Schienbein, I; Uggerhoj, U I

    2012-01-01

    We argue that the concept of a multi-purpose fixed-target experiment with the proton or lead-ion LHC beams extracted by a bent crystal would offer a number of ground-breaking precision-physics opportunities. The multi-TeV LHC beams will allow for the most energetic fixed-target experiments ever performed. The fixed-target mode has the advantage of allowing for high luminosities, spin measurements with a polarised target, and access over the full backward rapidity domain --uncharted until now-- up to x_F ~ -1.

  9. Renaissance of the ~1 TeV Fixed-Target Program

    CERN Document Server

    Adams, T; Arms, K E; Balantekin, A B; Conrad, J M; Cooper, P S; Djurcic, Z; Dunwoodie, W; Engelfried, J; Fisher, P H; Gottschalk, E; De Gouvêa, A; Heller, K; Ignarra, C M; Karagiorgi, G; Kwan, S; Loinaz, W A; Meadows, B; Moore, R; Morfín, J G; Naples, D; Nienaber, P; Pate, S F; Papavassiliou, V; Petrov, A A; Purohit, M V; Ray, H; Russ, J; Schwartz, A J; Seligman, W G; Shaevitz, M H; Schellman, H; Spitz, J; Syphers, M J; Tait, T M P; Vannucci, F

    2009-01-01

    This document describes the physics potential of a new fixed-target program based on a ~1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  10. Super-resolution infrared time measurement method based on target dynamic characteristics

    Science.gov (United States)

    Li, Bin; Hu, Qiuping; Tang, Zili; Zhang, Sanxi; Zhang, Hua; Yue, Peng; Liu, Biao

    2016-10-01

    High precision time control in the use of weapons and equipment is an important part of product design and development. In order to satisfy the data acquisition requirement of high accuracy and reliability in the rapid flight process, the super-resolution time measurement method based on target dynamic characteristics was put forward and proved by the cabin opening time measurement experiment. First, the changes of explosion pressure wave and image in the cabin opening process were analyzed in detail. The change regulation of explosion flame shape was analyzed by the characteristics of typical pressure wave, and then the high frequency images of the explosion process were shot by high speed camera. The change regulation of the infrared image was obtained through the comparison of visible and infrared image mechanism. Then, combined with the target motion features, and the observed station parameters, the observation model of movement process was built. On the basis of the above research, the infrared characteristic and the movement characteristic were transformed, and the super resolution model was established. For test method, combined with the actual class time measuring process in experimental design, to obtain the special radar for measuring high precision open class time as the true value of the precision appraisal. Experimental results show that the infrared feature and motion feature can realize open class time super resolution measurement, can effectively improve the accuracy and reliability of the data, to achieve specific action of high accuracy measurement that plays an important role by making use of the target dynamic characteristics.

  11. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Science.gov (United States)

    2010-10-01

    ... target cost plus the firm target profit as a guide. (ii) If negotiation of a firm fixed price is... pricing information is not sufficient to permit the negotiation of a realistic firm target cost and profit...; and (2) Cost or pricing information adequate for establishing a reasonable firm target cost is...

  12. Development of Single-side Magnet Array for Super Paramagnetic Nano-particle Targeting

    Directory of Open Access Journals (Sweden)

    Wei He

    2014-04-01

    Full Text Available Permanent magnets are interesting for the use in magnetic drug targeting devices. The magnetic fields and forces with distances from magnets have limited the depth of targeting. Producing greater forces at deep depth by optimally designed magnet arrays would allow treatment of a wider class of patients. In this study, we present a design of a permanent magnet array for deep magnetic capture of super paramagnetic iron oxide nano-particles, which consists of an array of 3 individual bar permanent magnet positioned to achieve a reasonably magnitude magnetic field and its gradient within a deeply region. These configurations were simulated with two-dimensional finite-element methods. The super paramagnetic iron oxide nano-particles were adopted Fe3O4 particles with diameter 40 nm by chemical co-precipitation method. Performance factors were defined to relate magnetic field force with mass. The field strength and gradient were measured by a Hall probe and agreed well with the simulations.

  13. Spin physics at A Fixed-Target ExpeRiment at the LHC (AFTER@LHC)

    CERN Document Server

    Rakotozafindrabe, A; Arnaldi, R; Brodsky, S J; Chambert, V; Didelez, J P; Ferreiro, E G; Fleuret, F; Genolini, B; Hadjidakis, C; Lansberg, J P; Lorce, C; Rosier, P; Schienbein, I; Scomparin, E; Uggerhoj, U I

    2013-01-01

    We outline the opportunities for spin physics which are offered by a next generation and multi-purpose fixed-target experiment exploiting the proton LHC beam extracted by a bent crystal. In particular, we focus on the study of single transverse spin asymetries with the polarisation of the target.

  14. High-power production targets for the Super-FRS using a fast extraction scheme

    CERN Document Server

    Tahir, N A; Kojouharova, J; Roussel-Chomaz, P; Chishkine, V; Geissel, H; Hoffmann, Dieter H H; Kindler, B; Landre-Pellemoine, F; Lommel, B; Mittig, W; Münzenberg, G; Shutov, A; Weick, H; Yavor, M

    2003-01-01

    The high-power production target of the Super-FRS [H. Geissel et al., these Proceedings] will be irradiated by very intense heavy-ion beams which will be delivered from the future SIS100/200 [An International Accelerator Facility for Beams of Ions and Antiprotons, GSI-Report, 2001] synchrotron facility at the Gesellschaft fuer Schwerionenforschung (GSI) Darmstadt. This paper presents calculations of the thermodynamic and the hydrodynamic response of such a target, considering that a uranium ion beam with an energy of 1 GeV/u and an intensity of 10 sup 1 sup 2 particles will impinge within 50 ns on a solid carbon target with a thickness of 4 g/cm sup 2. Due to the high beam intensity the target may be strongly heated and could be destroyed in a single shot. The purpose of this work is to investigate with the help of two-dimensional numerical simulations how one can minimize target heating and avoid target destruction.

  15. Near-Threshold Production of W±, Z0, and H0 at a Fixed-Target Experiment at the Future Ultrahigh-Energy Proton Colliders

    Directory of Open Access Journals (Sweden)

    J. P. Lansberg

    2015-01-01

    Full Text Available We outline the opportunities to study the production of the Standard Model bosons, W±, Z0, and H0, at “low” energies at fixed-target experiments based on possible future ultrahigh-energy proton colliders, that is, the High-Energy LHC, the Super proton-proton Collider, and the Future Circular Collider hadron-hadron. These can be indeed made in conjunction with the proposed future colliders designed to reach up to s=100 TeV by using bent crystals to extract part of the halo of the beam which would then impinge on a fixed target. Without disturbing the collider operation, this technique allows for the extraction of a substantial amount of particles in addition to serving for a beam-cleaning purpose. With this method, high-luminosity fixed-target studies at centre-of-mass energies above the W±, Z0, and H0 masses, s≃170–300 GeV, are possible. We also discuss the possibility offered by an internal gas target, which can also be used as luminosity monitor by studying the beam transverse shape.

  16. Studying the high x frontier with A Fixed-Target ExpeRiment at the LHC

    CERN Document Server

    Rakotozafindrabe, A; Arnaldi, R; Brodsky, S J; Chambert, V; Didelez, J P; Ferreiro, E G; Fleuret, F; Genolini, B; Hadjidakis, C; Lansberg, J P; Lorce, C; Rosier, P; Schienbein, I; Scomparin, E; Uggerhoj, U I

    2013-01-01

    The opportunities which are offered by a next generation and multi-purpose fixed-target experiment exploiting the proton and lead LHC beams extracted by a bent crystal are outlined. In particular, such an experiment can greatly complement facilities with lepton beams by unraveling the partonic structure of polarised and unpolarised nucleons and of nuclei, especially at large momentum fractions.

  17. Super twisting controller for on-orbit servicing to non-cooperative target

    Directory of Open Access Journals (Sweden)

    Chen Binglong

    2015-02-01

    Full Text Available A relative position and attitude coupled controller is proposed for rendezvous and docking between two docking ports located in different spacecraft. It is concerned with servicing to a tumbling non-cooperative target spacecraft in arbitrary orbit subjected to external disturbances. By considering both kinematic and dynamical coupled effects of relative rotation on relative translation, a coupled dynamic model is established to represent the relative motion of docking port on target spacecraft with respect to another on the service spacecraft. The spacecraft control is based on the second order sliding mode algorithm of super twisting (ST. It is schemed to manipulate the relative position and attitude synchronously. A formal proof of the finite time convergence property of the closed-loop system is derived theoretically by the second method of Lyapunov. Numerical simulations with the designed ST controller are presented to validate the analytic analysis by contrast with the twisting control algorithm. Simulation results demonstrate that the proposed relative position and attitude integrated controller is characterized by high precision, strong robustness and high reliability.

  18. Super twisting controller for on-orbit servicing to non-cooperative target

    Institute of Scientific and Technical Information of China (English)

    Chen Binglong; Geng Yunhai

    2015-01-01

    A relative position and attitude coupled controller is proposed for rendezvous and dock-ing between two docking ports located in different spacecraft. It is concerned with servicing to a tumbling non-cooperative target spacecraft in arbitrary orbit subjected to external disturbances. By considering both kinematic and dynamical coupled effects of relative rotation on relative trans-lation, a coupled dynamic model is established to represent the relative motion of docking port on target spacecraft with respect to another on the service spacecraft. The spacecraft control is based on the second order sliding mode algorithm of super twisting (ST). It is schemed to manipulate the relative position and attitude synchronously. A formal proof of the finite time convergence property of the closed-loop system is derived theoretically by the second method of Lyapunov. Numerical simulations with the designed ST controller are presented to validate the analytic analysis by con-trast with the twisting control algorithm. Simulation results demonstrate that the proposed relative position and attitude integrated controller is characterized by high precision, strong robustness and high reliability.

  19. Tracking target and distractor processing in fixed-feature visual search: evidence from human electrophysiology.

    Science.gov (United States)

    Jannati, Ali; Gaspar, John M; McDonald, John J

    2013-12-01

    Salient distractors delay visual search for less salient targets in additional-singleton tasks, even when the features of the stimuli are fixed across trials. According to the salience-driven selection hypothesis, this delay is due to an initial attentional deployment to the distractor. Recent event-related potential (ERP) studies found no evidence for salience-driven selection in fixed-feature search, but the methods employed were not optimized to isolate distractor ERP components such as the N2pc and distractor positivity (PD; indices of selection and suppression, respectively). Here, we isolated target and distractor ERPs in two fixed-feature search experiments. Participants searched for a shape singleton in the presence of a more-salient color singleton (Experiment 1) or for a color singleton in the presence of a less-salient shape singleton (Experiment 2). The salient distractor did not elicit an N2pc, but it did elicit a PD on fast-response trials. Furthermore, distractors had no effect on the timing of the target N2pc. These results indicate that (a) the distractor was prevented from engaging the attentional mechanism associated with N2pc, (b) the distractor did not interrupt the deployment of attention to the target, and (c) competition for attention can be resolved by suppressing locations of irrelevant items on a salience-based priority map.

  20. Allocating the Fixed Resources and Setting Targets in Integer Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Kobra Gholami

    2013-11-01

    Full Text Available Data envelopment analysis (DEA is a non-parametric approach to evaluate a set of decision making units (DMUs consuming multiple inputs to produce multiple outputs. Formally, DEA use to estimate the efficiency score into the empirical efficient frontier. Also, DEA can be used to allocate resources and set targets for future forecast. The data are continuous in the standard DEA model whereas there are many problems in the real life that data must be integer such as number of employee, machinery, expert and so on. Thus in this paper we propose an approach to allocate fixed resources and set fixed targets with selective integer assumption that is based on an integer data envelopment analysis (IDEA approach for the first time. The major aim in this approach is preserving the efficiency score of DMUs. We use the concept of benchmarking to reach this aim. The numerical example gets to illustrate the applicability of the proposed method.

  1. Analysis of charmonium production at fixed-target experiments in the NRQCD approach

    CERN Document Server

    Maltoni, F; Bargiotti, M; Bertin, A; Bruschi, M; De Castro, S; Fabbri, L; Faccioli, P; Giacobbe, B; Grimaldi, F; Massa, I; Piccinini, M; Semprini-Cesari, N; Spighi, R; Villa, M; Vitale, A; Zoccoli, A

    2006-01-01

    We present an analysis of the existing data on charmonium hadro-production based on non-relativistic QCD (NRQCD) calculations at the next-to-leading order (NLO). All the data on J/psi and psi' production in fixed-target experiments and on pp collisions at low energy are included. We find that the amount of color octet contribution needed to describe the data is about 1/10 of that found at the Tevatron.

  2. Super-paramagnetic loaded nanoparticles based on biological macromolecules for in vivo targeted MR imaging.

    Science.gov (United States)

    Sanjai, Chutimon; Kothan, Suchart; Gonil, Pattarapond; Saesoo, Somsak; Sajomsang, Warayuth

    2016-05-01

    Target-specific MRI contrast agent based on super-paramagnetic iron oxide-chitosan-folic acid (SPIONP-CS-FA) nanoparticles was fabricated by using an ionotropic gelation method, which involved the loading of SPIONPs at various concentrations into CS-FA nanoparticles by electrostatic interaction. The SPIONP-CS-FA nanoparticles were characterized by ATR-FTIR, XRD, TEM, and VSM techniques. This study revealed that the advantages of this system would be green fabrication, low cytotoxicity at iron concentrations ranging from 0.52 mg/L to 4.16 mg/L, and high water stability (pH 6) at 4°C over long periods. Average particle size and positive zeta-potential of the SPIONP-CS-FA nanoparticles was found to be 130 nm with narrow size distribution and 42 mV, respectively. In comparison to SPIONP-0.5-CS nanoparticles, SPIONP-0.5-CS-FA nanoparticles showed higher and specific cellular uptake levels into human cervical adenocarcinoma cells due to the presence of folate receptors, while in vivo results (Wistar rat) indicated that only liver tissue showed significant decreases in MR image intensity on T2 weighted images and T2* weighted images after post-injection, in comparison with other organs. Our results demonstrated that SPIONP-CS-FA nanoparticles can be applied as an either tumor or organ specific MRI contrast agents.

  3. Integrated Guidance and Control of Homing Missiles Against Ground Fixed Targets

    Institute of Scientific and Technical Information of China (English)

    Hou Mingzhe; Duan Guangren

    2008-01-01

    This paper presents a scheme of integrated guidance and autopilot design for homing missiles against ground fixed targets. An in- tegrated guidance and control model in the pitch plane is formulated and further changed into a normal form by nonlinear coordinate transformation. By adopting the sliding mode control approach, an adaptive nonlinear control law of the system is designed so that the missile can hit the target accurately with a desired impact attitude angle. The stability analysis of the closed-loop system is also con- ducted. The numerical simulation has confirmed the usefulness of the proposed design scheme.

  4. Fixed target project AFTER at the LHC beams for heavy ion and hadron physics

    Science.gov (United States)

    Kurepin, A. B.; Topilskaya, N. S.

    2017-09-01

    High intensity proton and lead ion beams at the LHC collider allow one to use the beam halo by placing a fixed target or a bent crystal for beam extraction. The particle energy in this case is just half that at the RHIC collider, but the luminosity exceeds the collider luminosity many times. It is also possible to install a polarized target in the extracted beam. The project AFTER is aimed at investigation of rare processes, polarization phenomena, determination of the parameters required for analysis of cosmic rays and neutrino astrophysics, detailed investigation of quarkonia production and suppression depending on the phase transition of matter to the quark-gluon phase.

  5. AGS SUPER NEUTRINO BEAM FACILITY ACCELERATOR AND TARGET SYSTEM DESIGN (NEUTRINO WORKING GROUP REPORT-II).

    Energy Technology Data Exchange (ETDEWEB)

    DIWAN,M.; MARCIANO,W.; WENG,W.; RAPARIA,D.

    2003-04-21

    This document describes the design of the accelerator and target systems for the AGS Super Neutrino Beam Facility. Under the direction of the Associate Laboratory Director Tom Kirk, BNL has established a Neutrino Working Group to explore the scientific case and facility requirements for a very long baseline neutrino experiment. Results of a study of the physics merit and detector performance was published in BNL-69395 in October 2002, where it was shown that a wide-band neutrino beam generated by a 1 MW proton beam from the AGS, coupled with a half megaton water Cerenkov detector located deep underground in the former Homestake mine in South Dakota would be able to measure the complete set of neutrino oscillation parameters: (1) precise determination of the oscillation parameters {Delta}m{sub 32}{sup 2} and sin{sup 2} 2{theta}{sub 32}; (2) detection of the oscillation of {nu}{sub {mu}}-{nu}{sub e} and measurement of sin{sup 2} 2{theta}{sub 13}; (3) measurement of {Delta}m{sub 21}{sup 2} sin 2{theta}{sub 12} in a {nu}{sub {mu}} {yields} {nu}{sub e} appearance mode, independent of the value of {theta}{sub 13}; (4) verification of matter enhancement and the sign of {Delta}m{sub 32}{sup 2}; and (5) determination of the CP-violation parameter {delta}{sub CP} in the neutrino sector. This report details the performance requirements and conceptual design of the accelerator and the target systems for the production of a neutrino beam by a 1.0 MW proton beam from the AGS. The major components of this facility include a new 1.2 GeV superconducting linac, ramping the AGS at 2.5 Hz, and the new target station for 1.0 MW beam. It also calls for moderate increase, about 30%, of the AGS intensity per pulse. Special care is taken to account for all sources of proton beam loss plus shielding and collimation of stray beam halo particles to ensure equipment reliability and personal safety. A preliminary cost estimate and schedule for the accelerator upgrade and target system are also

  6. High Transverse Momentum Direct Photon Production at Fermilab Fixed-Target Energies

    Energy Technology Data Exchange (ETDEWEB)

    Apanasevich, Leonard [Michigan State Univ., East Lansing, MI (United States)

    2005-01-01

    This thesis describes a study of the production of high transverse momentum direct photons and π0 mesons by proton beams at 530 and 800 GeV/c and π- beams at 515 GeV/c incident on beryllium, copper, and liquid hydrogen targets. The data were collected by Fermilab experiment E706 during the 1990 and 1991-92 fixed target runs. The apparatus included a large, finely segmented lead and liquid argon electromagnetic calorimeter and a charged particle spectrometer featuring silicon strip detectors in the target region and proportional wire chambers and drift tubes downstream of a large aperture analysis magnet. The inclusive cross sections are presented as functions of transverse momentum and rapidity. The measurements are compared with next-to-leading order perturbative QCD calculations and to results from previous experiments.

  7. Physics Opportunities of a Fixed-Target Experiment using the LHC Beams

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S.J.; /SLAC; Fleuret, F.; /Ecole Polytechnique; Hadjidakis, C.; Lansberg, J.P.; /Orsay, IPN

    2012-03-16

    We outline the many physics opportunities offered by a multi-purpose fixed-target experiment using the proton and lead-ion beams of the LHC extracted by a bent crystal. In a proton run with the LHC 7-TeV beam, one can analyze pp, pd and pA collisions at center-of-mass energy {radical}s{sub NN} {approx_equal} 115 GeV and even higher using the Fermi motion of the nucleons in a nuclear target. In a lead run with a 2.76 TeV-per-nucleon beam, {radical}s{sub NN} is as high as 72 GeV. Bent crystals can be used to extract about 5 x 10{sup 8} protons/sec; the integrated luminosity over a year reaches 0.5 fb{sup -1} on a typical 1 cm-long target without nuclear species limitation. We emphasize that such an extraction mode does not alter the performance of the collider experiments at the LHC. By instrumenting the target-rapidity region, gluon and heavy-quark distributions of the proton and the neutron can be accessed at large x and even at x larger than unity in the nuclear case. Single diffractive physics and, for the first time, the large negative-xF domain can be accessed. The nuclear target-species versatility provides a unique opportunity to study nuclear matter versus the features of the hot and dense matter formed in heavy-ion collisions, including the formation of the quark-gluon plasma, which can be studied in PbA collisions over the full range of target-rapidity domain with a large variety of nuclei. The polarization of hydrogen and nuclear targets allows an ambitious spin program, including measurements of the QCD lensing effects which underlie the Sivers single-spin asymmetry, the study of transversity distributions and possibly of polarized parton distributions. We also emphasize the potential offered by pA ultra-peripheral collisions where the nucleus target A is used as a coherent photon source, mimicking photoproduction processes in ep collisions. Finally, we note that W and Z bosons can be produced and detected in a fixed-target experiment and in their

  8. Fixed target measurements at LHCb for cosmic rays physics arXiv

    CERN Document Server

    Graziani, Giacomo

    The LHCb experiment has the unique possibility, among the LHC experiments, to be operated in fixed target mode, using its internal gas target. The energy scale achievable at the LHC, combined with the LHCb forward geometry and detector capabilities, allow to explore particle production in a wide Bjorken-$x$ range at the $\\sqrt{s_{\\scriptscriptstyle\\rm NN}} \\sim 100$ GeV energy scale, providing novel inputs to nuclear and cosmic ray physics. The first measurement of antiproton production in collisions of LHC protons on helium nuclei at rest is presented. The knowledge of this cross-section is of great importance for the study of the cosmic antiproton flux, and the LHCb results are expected to improve the interpretation of the recent high-precision measurements of cosmic antiprotons performed by the space-borne PAMELA and AMS-02 experiments.

  9. Spin and diffractive physics with A Fixed-Target ExpeRiment at the LHC (AFTER@LHC)

    CERN Document Server

    Lorce, C; Arnaldi, R; Brodsky, S J; Chambert, V; Didelez, J P; Ferreiro, E G; Fleuret, F; Genolini, B; Hadjidakis, C; Lansberg, J P; Rakotozafindrabe, A; Rosier, P; Schienbein, I; Scomparin, E; Uggerhoj, U I

    2012-01-01

    We report on the spin and diffractive physics at a future multi-purpose fixed-target experiment with proton and lead LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic fixed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER using typical targets would surpass that of RHIC by more than 3 orders of magnitude. The fixed-target mode has the advantage to allow for measurements of single-spin asymmetries with polarized target as well as of single-diffractive processes in the target region.

  10. Regulation of Differentiation of Nitrogen-Fixing Bacteria by Microsymbiont Targeting of Plant Thioredoxin s1.

    Science.gov (United States)

    Ribeiro, Carolina Werner; Baldacci-Cresp, Fabien; Pierre, Olivier; Larousse, Marie; Benyamina, Sofiane; Lambert, Annie; Hopkins, Julie; Castella, Claude; Cazareth, Julie; Alloing, Geneviève; Boncompagni, Eric; Couturier, Jérémy; Mergaert, Peter; Gamas, Pascal; Rouhier, Nicolas; Montrichard, Françoise; Frendo, Pierre

    2017-01-23

    Legumes associate with rhizobia to form nitrogen (N2)-fixing nodules, which is important for plant fitness [1, 2]. Medicago truncatula controls the terminal differentiation of Sinorhizobium meliloti into N2-fixing bacteroids by producing defensin-like nodule-specific cysteine-rich peptides (NCRs) [3, 4]. The redox state of NCRs influences some biological activities in free-living bacteria, but the relevance of redox regulation of NCRs in planta is unknown [5, 6], although redox regulation plays a crucial role in symbiotic nitrogen fixation [7, 8]. Two thioredoxins (Trx), Trx s1 and s2, define a new type of Trx and are expressed principally in nodules [9]. Here, we show that there are four Trx s genes, two of which, Trx s1 and s3, are induced in the nodule infection zone where bacterial differentiation occurs. Trx s1 is targeted to the symbiosomes, the N2-fixing organelles. Trx s1 interacted with NCR247 and NCR335 and increased the cytotoxic effect of NCR335 in S. meliloti. We show that Trx s silencing impairs bacteroid growth and endoreduplication, two features of terminal bacteroid differentiation, and that the ectopic expression of Trx s1 in S. meliloti partially complements the silencing phenotype. Thus, our findings show that Trx s1 is targeted to the bacterial endosymbiont, where it controls NCR activity and bacteroid terminal differentiation. Similarly, Trxs are critical for the activation of defensins produced against infectious microbes in mammalian hosts. Therefore, our results suggest the Trx-mediated regulation of host peptides as a conserved mechanism among symbiotic and pathogenic interactions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations

    Science.gov (United States)

    Sadick, Jessica S.; Boutin, Molly E.; Hoffman-Kim, Diane; Darling, Eric M.

    2016-01-01

    Cellular heterogeneity is inherent in most human tissues, making the investigation of specific cell types challenging. Here, we describe a novel, fixation/intracellular target-based sorting and protein extraction method to provide accurate protein characterization for cell subpopulations. Validation and feasibility tests were conducted using homogeneous, neural cell lines and heterogeneous, rat brain cells, respectively. Intracellular proteins of interest were labeled with fluorescent antibodies for fluorescence-activated cell sorting. Reproducible protein extraction from fresh and fixed samples required lysis buffer with high concentrations of Tris-HCl and sodium dodecyl sulfate as well as exposure to high heat. No deterioration in protein amount or quality was observed for fixed, sorted samples. For the feasibility experiment, a primary rat subpopulation of neuronal cells was selected for based on high, intracellular β-III tubulin signal. These cells showed distinct protein expression differences from the unsorted population for specific (phosphorylated tau) and non-specific (total tau) protein targets. Our approach allows for determining more accurate protein profiles directly from cell types of interest and provides a platform technology in which any cell subpopulation can be biochemically investigated. PMID:27666089

  12. World-volume and target-space anomalies in the D=10 super-fivebrane sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Lechner, K. [Padua Univ. (Italy). Dipt. di Fisica; Tonin, M. [Padua Univ. (Italy). Dipt. di Fisica

    1996-09-16

    The fields of the conjectured ``heterotic`` super-fivebrane sigma model in ten dimensions are made out of a well-known gravitational sector, the X and the {theta}, and of a still unknown heterotic sector which should be coupled to the Yang-Mills fields. We compute the one-loop d=6 world-volume and D=10 target-space Lorentz anomalies which arise from the gravitational sector of the heterotic super-fivebrane sigma model, using a method which we developed previously for the Green-Schwarz heterotic superstring. These anomalies turn out to carry an overall coefficient which is half of that required by the string-fivebrane duality conjecture. As a consequence, the world-volume anomaly vanishes if the heterotic fields consist of 16 (rather than 32) complex Weyl fermions on the world-volume. This implies that the string-fivebrane duality conjecture can not be based on a ``heterotic`` super-fivebrane sigma model with only fermions in the heterotic sector. Possible implications of this result are discussed. (orig.).

  13. Quarkonium Physics at a Fixed-Target Experiment Using the LHC Beams

    Energy Technology Data Exchange (ETDEWEB)

    Lansberg, J.P.; /Orsay, IPN; Brodsky, S.J.; /SLAC; Fleuret, F.; /Ecole Polytechnique; Hadjidakis, C.; /Orsay, IPN

    2012-04-09

    We outline the many quarkonium-physics opportunities offered by a multi-purpose fixed-target experiment using the p and Pb LHC beams extracted by a bent crystal. This provides an integrated luminosity of 0.5 fb{sup -1} per year on a typical 1cm-long target. Such an extraction mode does not alter the performance of the collider experiments at the LHC. With such a high luminosity, one can analyse quarkonium production in great details in pp, pd and pA collisions at {radical}s{sub NN} {approx_equal} 115 GeV and at {radical}s{sub NN} {approx_equal} 72 GeV in PbA collisions. In a typical pp (pA) run, the obtained quarkonium yields per unit of rapidity are 2-3 orders of magnitude larger than those expected at RHIC and about respectively 10 (70) times larger than for ALICE. In PbA, they are comparable. By instrumenting the target-rapidity region, the large negative-x{sub F} domain can be accessed for the first time, greatly extending previous measurements by Hera-B and E866. Such analyses should help resolving the quarkonium-production controversies and clear the way for gluon PDF extraction via quarkonium studies. The nuclear target-species versatility provides a unique opportunity to study nuclear matter and the features of the hot and dense matter formed in PbA collisions. A polarised proton target allows the study of transverse-spin asymmetries in J/{Psi} and {Upsilon} production, providing access to the gluon and charm Sivers functions.

  14. The unified database for the fixed target experiment BM@N

    Science.gov (United States)

    Gertsenberger, K. V.

    2016-09-01

    The article describes the developed database designed as comprehensive data storage of the fixed target experiment BM@N [1] at Joint Institute for Nuclear Research (JINR) in Dubna. The structure and purposes of the BM@N facility will be briefly presented. The scheme of the unified database and its parameters will be described in detail. The use of the BM@N database implemented on the PostgreSQL database management system (DBMS) allows one to provide user access to the actual information of the experiment. Also the interfaces developed for the access to the database will be presented. One was implemented as the set of C++ classes to access the data without SQL statements, the other-Web-interface being available on the Web page of the BM@N experiment.

  15. Nucleon PDF separation with the collider and fixed-target data

    CERN Document Server

    Alekhin, S; Caminada, L; Lipka, K; Lohwasser, K; Moch, S; Petti, R; Placakyte, R

    2014-01-01

    We consider the impact of the recent data obtained by the LHC, Tevatron, and fixed-target experiments on the nucleon quark distributions with a particular focus on disentangling different quark species. An improved determination of the poorly known strange sea distribution is obtained due to including data from the neutrino-induced deep-inelastic scattering experiments NOMAD and CHORUS. The impact of the associated (W + c) production data by CMS and ATLAS on the strange sea determination is also studied and a comparison with earlier results based on the collider data is discussed. Finally, the recent LHC and Tevatron data on the charged lepton asymmetry are compared to the NNLO ABM predictions and the potential of this input in improving the non-strange sea distributions is evaluated.

  16. Nucleon PDF separation with the collider and fixed-target data

    Energy Technology Data Exchange (ETDEWEB)

    Alekhin, Sergey [Institute for High Energy Physics, Protvino, Moscow Region (Russian Federation); Bluemlein, Johannes; Lohwasser, Kristin [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Caminada, Lea Michaela [Zuerich Univ. (Switzerland). Physik Inst.; Lipka, Katerina; Placakyt e, Ringaile [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Moch, Sven-Olaf [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Petti, Roberto [South Carolina Univ., Columbia, SC (United States). Dept. of Physics and Astronomy

    2014-10-15

    We consider the impact of the recent data obtained by the LHC, Tevatron, and fixed-target experiments on the nucleon quark distributions with a particular focus on disentangling different quark species. An improved determination of the poorly known strange sea distribution is obtained due to including data from the neutrino-induced deep-inelastic scattering experiments NOMAD and CHORUS. The impact of the associated (W+c) production data by CMS and ATLAS on the strange sea determination is also studied and a comparison with earlier results based on the collider data is discussed. Finally, the recent LHC and Tevatron data on the charged lepton asymmetry are compared to the NNLO ABM predictions and the potential of this input in improving the non-strange sea distributions is evaluated.

  17. Free-time and fixed end-point multi-target optimal control theory: Application to quantum computing

    Science.gov (United States)

    Mishima, K.; Yamashita, K.

    2011-01-01

    An extension of free-time and fixed end-point optimal control theory (FRFP-OCT) to monotonically convergent free-time and fixed end-point multi-target optimal control theory (FRFP-MTOCT) is presented. The features of our theory include optimization of the external time-dependent perturbations with high transition probabilities, that of the temporal duration, the monotonic convergence, and the ability to optimize multiple-laser pulses simultaneously. The advantage of the theory and a comparison with conventional fixed-time and fixed end-point multi-target optimal control theory (FIFP-MTOCT) are presented by comparing data calculated using the present theory with those published previously [K. Mishima, K. Yamashita, Chem. Phys. 361, (2009), 106]. The qubit system of our interest consists of two polar NaCl molecules coupled by dipole-dipole interaction. The calculation examples show that our theory is useful for minor adjustment of the external fields.

  18. Low-Z polymer sample supports for fixed-target serial femtosecond X-ray crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Feld, Geoffrey K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); National Institute of Environmental Health Science, Research Triangle Park, NC (United States); Heymann, Michael [Brandeis Univ., Waltham, MA (United States); Univ. of Hamburg and DESY, Hamburg (Germany); Benner, W. Henry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pardini, Tommaso [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Tsai, Ching -Ju [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Boutet, Sebastien [SLAC National Accelerator Lab., Menlo Park, CA (United States); Coleman, Matthew A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hunter, Mark S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States); Li, Xiaodan [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Messerschmidt, Marc [SLAC National Accelerator Lab., Menlo Park, CA (United States); BioXFEL Science and Technology Center, Buffalo, NY (United States); Opathalage, Achini [Brandeis Univ., Waltham, MA (United States); Pedrini, Bill [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Williams, Garth J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Krantz, Bryan A. [Univ. of California, Berkeley, CA (United States); Fraden, Seth [Brandeis Univ., Waltham, MA (United States); Hau-Riege, Stefan [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Evans, James E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Segelke, Brent W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Frank, Matthias [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-06-27

    X-ray free-electron lasers (XFELs) offer a new avenue to the structural probing of complex materials, including biomolecules. Delivery of precious sample to the XFEL beam is a key consideration, as the sample of interest must be serially replaced after each destructive pulse. The fixed-target approach to sample delivery involves depositing samples on a thin-film support and subsequent serial introduction via a translating stage. Some classes of biological materials, including two-dimensional protein crystals, must be introduced on fixed-target supports, as they require a flat surface to prevent sample wrinkling. A series of wafer and transmission electron microscopy (TEM)-style grid supports constructed of low-Z plastic have been custom-designed and produced. Aluminium TEM grid holders were engineered, capable of delivering up to 20 different conventional or plastic TEM grids using fixed-target stages available at the Linac Coherent Light Source (LCLS). As proof-of-principle, X-ray diffraction has been demonstrated from two-dimensional crystals of bacteriorhodopsin and three-dimensional crystals of anthrax toxin protective antigen mounted on these supports at the LCLS. In conclusion, the benefits and limitations of these low-Z fixed-target supports are discussed; it is the authors' belief that they represent a viable and efficient alternative to previously reported fixed-target supports for conducting diffraction studies with XFELs.

  19. Investigation of super-resolution processing algorithm by target light-intensity search in digital holography

    Science.gov (United States)

    Neo, Atsushi; Kakue, Takashi; Shimobaba, Tomoyoshi; Masuda, Nobuyuki; Ito, Tomoyoshi

    2017-04-01

    Digital holography is expected to be useful in the analysis of moving three-dimensional (3D) image measurement. In this technique, a two-dimensional interference fringe recorded using a 3D image is captured with an image sensor, and the 3D image is reproduced on a computer. To obtain the reproduced 3D images with high spatial resolution, a high-performance image sensor is required, which increases the system cost. We propose an algorithm for super-resolution processing in digital holography that does not require a high-performance image sensor. The proposed algorithm wherein 3D images are considered as the aggregation of object points improves spatial resolution by performing a light-intensity search of the reproduced image and the object points.

  20. Double-quarkonium production at a fixed-target experiment at the LHC (AFTER@LHC

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Lansberg

    2015-11-01

    Full Text Available We present predictions for double-quarkonium production in the kinematical region relevant for the proposed fixed-target experiment using the LHC beams (dubbed as AFTER@LHC. These include all spin-triplet S-wave charmonium and bottomonium pairs, i.e. ψ(n1S+ψ(n2S, ψ(n1S+ϒ(m1S and ϒ(m1S+ϒ(m2S with n1,n2=1,2 and m1,m2=1,2,3. We calculate the contributions from double-parton scatterings and single-parton scatterings. With an integrated luminosity of 20 fb−1 to be collected at AFTER@LHC, we find that the yields for double-charmonium production are large enough for differential distribution measurements. We discuss some differential distributions for J/ψ+J/ψ production, which can help to study the physics of double-parton and single-parton scatterings in a new energy range and which might also be sensitive to double intrinsic cc¯ coalescence at large negative Feynman x.

  1. Study of the discovery potential for hidden photon emission at future electron scattering fixed target experiments

    CERN Document Server

    Beranek, T

    2013-01-01

    Electron scattering fixed target experiments are a versatile tool to explore various physics phenomena. Recently these experiments came into focus to search for $U(1)$ extensions of the Standard Model of particle physics at low energies. These extensions are motivated from anomalies in astrophysical observations as well as from deviations from Standard Model predictions, such as the discrepancy between the experimental and theoretical determination of the anomalous magnetic moment of the muon. They also arise naturally when the Standard Model is embedded into a more general theory. In the considered $U(1)$ extensions a new, light messenger particle $\\gamma^\\prime$, the hidden photon, couples to the hidden sector as well as to the electromagnetic current of the Standard Model by kinetic mixing, which allows for a search for this particle e.g. in the invariant mass distribution of the process $e (A,\\,Z)\\rightarrow e (A,\\,Z) l^+ l^-$. In this process the hidden photon is emitted by bremsstrahlung and decays into...

  2. Multi-robot coverage to locate fixed targets using formation structures

    CERN Document Server

    Rogge, Jonathan

    2012-01-01

    This paper develops an algorithm that guides a multi-robot system in an unknown environment in search of fixed targets. The area to be scanned contains an unknown number of convex obstacles of unknown size and shape. The algorithm covers the entire free space in a sweeping fashion and as such relies on the use of robot formations. The geometry of the robot group is a lateral line formation, which is allowed to split and rejoin when passing obstacles. It is our main goal to exploit this formation structure in order to reduce robot resources to a minimum. Each robot has a limited and finite amount of memory available. No information of the topography is recorded. Communication between two robots is only possible up to a maximum inter-robot distance, and if the line-of-sight between both robots is not obstructed. Broadcasting capabilities and indirect communication are not allowed. Supervisory control is prohibited. The number of robots equipped with GPS is kept as small as possible. Applications of the algorith...

  3. Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography.

    Science.gov (United States)

    Oghbaey, Saeed; Sarracini, Antoine; Ginn, Helen M; Pare-Labrosse, Olivier; Kuo, Anling; Marx, Alexander; Epp, Sascha W; Sherrell, Darren A; Eger, Bryan T; Zhong, Yinpeng; Loch, Rolf; Mariani, Valerio; Alonso-Mori, Roberto; Nelson, Silke; Lemke, Henrik T; Owen, Robin L; Pearson, Arwen R; Stuart, David I; Ernst, Oliver P; Mueller-Werkmeister, Henrike M; Miller, R J Dwayne

    2016-08-01

    The advent of ultrafast highly brilliant coherent X-ray free-electron laser sources has driven the development of novel structure-determination approaches for proteins, and promises visualization of protein dynamics on sub-picosecond timescales with full atomic resolution. Significant efforts are being applied to the development of sample-delivery systems that allow these unique sources to be most efficiently exploited for high-throughput serial femtosecond crystallography. Here, the next iteration of a fixed-target crystallography chip designed for rapid and reliable delivery of up to 11 259 protein crystals with high spatial precision is presented. An experimental scheme for predetermining the positions of crystals in the chip by means of in situ spectroscopy using a fiducial system for rapid, precise alignment and registration of the crystal positions is presented. This delivers unprecedented performance in serial crystallography experiments at room temperature under atmospheric pressure, giving a raw hit rate approaching 100% with an effective indexing rate of approximately 50%, increasing the efficiency of beam usage and allowing the method to be applied to systems where the number of crystals is limited.

  4. Heavy ion and fixed target physics at LHCb: results and prospects

    CERN Document Server

    CERN. Geneva

    2016-01-01

    In 2015, the LHCb collaboration endorsed the proposal to pursue an ambitious heavy ion physics program. In 2013, LHCb has demonstrated its capabilities to operate successfully in p-Pb and Pb-p collisions, leading already to several important publications in the field. The measurements of the nuclear modification factors and forward-backward production of prompt and displaced J/psi, psi(2S) and Upsilon states, as well as the production of prompt D0 mesons, have allowed to extend the knowledge of Cold Nuclear Matter effects on open heavy flavours and quarkonium production. The measurement of Z-boson production, important to constrain nuclear PDFs, and the measurement of two-particle angular correlations, probing collective effects in the dense environment of high energy collisions, have also been performed. Furthermore, LHCb is the only experiment at the LHC that can be operated in fixed-target mode, owing to the injection of a small amount of gas inside the LHCb collision area. There have been several p-gas an...

  5. Dilepton and φ meson production in elementary and nuclear collisions at the NICA fixed-target experiment

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, Gyoergy; Zetenyi, Miklos [Wigner Research Centre for Physics, Hungarian Academy of Sciences, Institute for Particle and Nuclear Physics, P.O. Box 49, Budapest (Hungary)

    2016-08-15

    We argue that the NICA fixed-target experiment will be able to provide very important new experimental data on dilepton and φ meson production in the basically undiscovered energy domain between the SIS and SPS energies. Experimental information about elementary cross sections in this energy region is an essential ingredient of models of nuclear collisions in the same energy range. (orig.)

  6. A Novel Fixed-Target Task to Determine Articulatory Speed Constraints in Persons with Amyotrophic Lateral Sclerosis

    Science.gov (United States)

    Mefferd, Antje S.; Green, Jordan R.; Pattee, Gary

    2012-01-01

    Purpose: The goal of this study was to determine if talkers with ALS are limited in their ability to increase lower lip and jaw speed at an early stage of the disease when their speaking rate and intelligibility are only minimally or not affected. Method: A novel metronome paced fixed-target task was used to assess movement speed capacities during…

  7. A Novel Fixed-Target Task to Determine Articulatory Speed Constraints in Persons with Amyotrophic Lateral Sclerosis

    Science.gov (United States)

    Mefferd, Antje S.; Green, Jordan R.; Pattee, Gary

    2012-01-01

    Purpose: The goal of this study was to determine if talkers with ALS are limited in their ability to increase lower lip and jaw speed at an early stage of the disease when their speaking rate and intelligibility are only minimally or not affected. Method: A novel metronome paced fixed-target task was used to assess movement speed capacities during…

  8. Rotating target wheel system for super-heavy element production at ATLAS

    CERN Document Server

    Greene, J P; Falout, J; Janssens, R V F

    2004-01-01

    A new scattering chamber housing a large diameter rotating target wheel has been designed and constructed in front of the Fragment Mass Analyzer (FMA) for the production of very heavy nuclei (Z greater than 100) using beams from the Argonne Tandem Linear Accelerator System (ATLAS). In addition to the target and drive system, the chamber is extensively instrumented in order to monitor target performance and deterioration. Capabilities also exist to install rotating entrance and exit windows for gas cooling of the target within the scattering chamber. The design and initial tests are described.

  9. Spin physics and TMD studies at A Fixed-Target ExpeRiment at the LHC (AFTER@LHC

    Directory of Open Access Journals (Sweden)

    Lansberg J.P.

    2015-01-01

    Full Text Available We report on the opportunities for spin physics and Transverse-Momentum Dependent distribution (TMD studies at a future multi-purpose fixed-target experiment using the proton or lead ion LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic fixed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER@LHC using typical targets would surpass that of RHIC by more that 3 orders of magnitude in a similar energy region. In unpolarised proton-proton collisions, AFTER@LHC allows for measurements of TMDs such as the Boer-Mulders quark distributions, the distribution of unpolarised and linearly polarised gluons in unpolarised protons. Using the polarisation of hydrogen and nuclear targets, one can measure transverse single-spin asymmetries of quark and gluon sensitive probes, such as, respectively, Drell-Yan pair and quarkonium production. The fixed-target mode has the advantage to allow for measurements in the target-rapidity region, namely at large x↑ in the polarised nucleon. Overall, this allows for an ambitious spin program which we outline here.

  10. Sub-Nyquist Field Trial Using Time Frequency Packed DP-QPSK Super-Channel Within Fixed ITU-T Grid

    CERN Document Server

    Potì, L; Berrettini, G; Fresi, F; Foggi, T; Secondini, M; Giorgi, L; Cavaliere, F; Hackett, S; Petronio, A; Nibbs, P; Forgan, R; Leong, A; Masciulli, R; Pfander, C

    2015-01-01

    Sub-Nyquist time frequency packing technique was demonstrated for the first time in a super channel field trial transmission over long-haul distances. The technique allows a limited spectral occupancy even with low order modulation formats. The transmission was successfully performed on a deployed Australian link between Sydney and Melbourne which included 995 km of uncompensated SMF with coexistent traffic. 40 and 100 Gb/s co-propagating channels were transmitted together with the super-channel in a 50 GHz ITU-T grid without additional penalty. The super-channel consisted of eight sub-channels with low-level modulation format, i.e. DP-QPSK, guaranteeing better OSNR robustness and reduced complexity with respect to higher order formats. At the receiver side, coherent detection was used together with iterative maximum-a-posteriori (MAP) detection and decoding. A 975 Gb/s DP-QPSK super-channel was successfully transmitted between Sydney and Melbourne within four 50GHz WSS channels (200 GHz). A maximum potential...

  11. Sub-Nyquist field trial using time frequency packed DP-QPSK super-channel within fixed ITU-T grid.

    Science.gov (United States)

    Potì, L; Meloni, G; Berrettini, G; Fresi, F; Foggi, T; Secondini, M; Giorgi, L; Cavaliere, F; Hackett, S; Petronio, A; Nibbs, P; Forgan, R; Leong, A; Masciulli, R; Pfander, C

    2015-06-15

    Sub-Nyquist time frequency packing technique was demonstrated for the first time in a super-channel field trial transmission over long-haul distances. The technique allows a limited spectral occupancy even with low order modulation formats. The transmission was successfully performed on a deployed Australian link between Sydney and Melbourne which included 995 km of uncompensated SMF with coexistent traffic. 40 and 100 Gb/s co-propagating channels were transmitted together with the super-channel in a 50 GHz ITU-T grid without additional penalty. The super-channel consisted of eight sub-channels with low-level modulation format, i.e. DP-QPSK, guaranteeing better OSNR robustness and reduced complexity with respect to higher order formats. At the receiver side, coherent detection was used together with iterative maximum-a-posteriori (MAP) detection and decoding. A 975 Gb/s DP-QPSK super-channel was successfully transmitted between Sydney and Melbourne within four 50GHz WSS channels (200 GHz). A maximum potential SE of 5.58 bit/s/Hz was achieved with an OSNR = 15.8 dB, comparable to the OSNR of the installed 100 Gb/s channels. The system reliability was proven through long term measurements. In addition, by closing the link in a loop back configuration, a potential SE∙d product of 9254 bit/s/Hz·km was achieved.

  12. A proof that uniform dose gives the greatest TCP for fixed integral dose in the planning target volume

    Energy Technology Data Exchange (ETDEWEB)

    Webb, S.; Evans, P.M.; Swindell, W. (Institute of Cancer Research, Sutton (United Kingdom). Surrey Branch Royal Marsden Hospital, Sutton (United Kingdom)); Deasy, J.O. (Wisconsin Univ., Madison, WI (United States). Dept. of Medical Physics Wisconsin Univ., Madison, WI (United States). Dept. of Human Oncology)

    1994-11-01

    In this note it is shown that for a fixed integral dose to the planning target volume, the highest tumour control probability arises when the dose is spatially uniform. This 'uniform dose theorem' is proved both for (i) a specific TCP model based on Poisson/independent voxel statistics and (ii) any model for voxel control probability having a specific shape with respect to increasing dose. (author).

  13. Super natural killer cells that target metastases in the tumor draining lymph nodes.

    Science.gov (United States)

    Chandrasekaran, Siddarth; Chan, Maxine F; Li, Jiahe; King, Michael R

    2016-01-01

    Tumor draining lymph nodes are the first site of metastasis in most types of cancer. The extent of metastasis in the lymph nodes is often used in staging cancer progression. We previously showed that nanoscale TRAIL liposomes conjugated to human natural killer cells enhance their endogenous therapeutic potential in killing cancer cells cultured in engineered lymph node microenvironments. In this work, it is shown that liposomes decorated with apoptosis-inducing ligand TRAIL and an antibody against a mouse natural killer cell marker are carried to the tumor draining inguinal lymph nodes and prevent the lymphatic spread of a subcutaneous tumor in mice. It is shown that targeting natural killer cells with TRAIL liposomes enhances their retention time within the tumor draining lymph nodes to induce apoptosis in cancer cells. It is concluded that this approach can be used to kill cancer cells within the tumor draining lymph nodes to prevent the lymphatic spread of cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Spin physics and TMD studies at A Fixed-Target ExpeRiment at the LHC (AFTER@LHC)

    CERN Document Server

    Lansberg, J P; Arnaldi, R; Brodsky, S J; Chambert, V; Dunnen, W den; Didelez, J P; Genolini, B; Ferreiro, E G; Fleuret, F; Gao, Y; Hadjidakis, C; Hrvinacova, I; Lorce, C; Massacrier, L; Mikkelsen, R; Pisano, C; Rakotozafindrabe, A; Rosier, P; Schienbein, I; Schlegel, M; Scomparin, E; Trzeciak, B; Uggerhoj, U I; Ulrich, R; Yang, Z

    2014-01-01

    We report on the opportunities for spin physics and Transverse-Momentum Dependent distribution (TMD) studies at a future multi-purpose fixed-target experiment using the proton or lead ion LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic fixed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER@LHC using typical targets would surpass that of RHIC by more that 3 orders of magnitude in a similar energy region. In unpolarised proton-proton collisions, AFTER@LHC allows for measurements of TMDs such as the Boer-Mulders quark distributions, the distribution of unpolarised and linearly polarised gluons in unpolarised protons. Using the polarisation of hydrogen and nuclear targets, one can measure transverse single-spin asymmetries of quark and gluon sensitive probes, such as, respectively, Drell-Yan pair and quar...

  15. The Substitution of a Super Black Fixed Micro-Object for an Optical Microcavity in a Delayed Choice Experiment to Send Information Immediately Between 2 Paired Particles: Simplifying the Experiment

    Science.gov (United States)

    Snyder, Douglas

    2015-04-01

    An experiment has been described that relies on a delayed choice for an idler photon that immediately affects the signal photon with which it is at least initially entangled and for which the idler photon provides which-way information. The delayed choice concerns whether to maintain or eliminate the entanglement before any measurements are made. In one option of the delayed choice, the entanglement can be eliminated because the relevant state of the idler photon related to its entanglement is eliminated when the idler photon enters an optical microcavity filled with photons with the same mode as the incoming idler photon. The microcavity is located at the crossroads of two possible idler photon paths. The relevant state of the idler photon characterizes the particular path taken by the photon and this information is eliminated when the particle enters the cavity. Over a number of runs with this choice, the distribution of the paired signal photons shows interference. If the entanglement is maintained, the distribution of the paired signal photons shows which-way information. This experiment can be simplified by using a super black material (e.g., Vantablack) affixed to a fixed micro-object located at the crossroads of the two possible idler photon paths instead of the optical microcavity. The photon would be absorbed by the material and there would be no way to detect from which direction it came. Objects such as fixed mirrors in a Mach Zehnder interferometer do not provide ww information. The super black fixed micro-object should not either.

  16. Spin and diffractive physics with a fixed-target experiment at the LHC (AFTER-LHC)

    Energy Technology Data Exchange (ETDEWEB)

    Lorce, C.; Chambert, V.; Didelez, J. P.; Genolini, B.; Hadjidakis, C.; Lansberg, J. P.; Rosier, P. [IPNO, Universite Paris-Sud, CNRS/IN2P3, F-91406, Orsay (France); Anselmino, M.; Arnaldi, R.; Scomparin, E. [INFN Sez. Torino, Via P. Giuria 1,1-10125, Torino (Italy); Brodsky, S. J. [SLAC National Accelerator Laboratory, Stanford U, Stanford, CA 94309, (United States); Ferreiro, E. G. [Departamento de Fisica de Particulas, Univ. de Santiago de C, 15782 Santiago de C (Spain); Fleuret, F. [Laboratoire Leprince Ringuet, Ecole Polytechnique, CNRS/IN2P3, 91128 Palaiseau (France); Rakotozafindrabe, A. [IRFU/SPhN, CFA Society, 91191 Gifsur-Yvette Cedex (France); Schienbein, I. [LPSC, Universite Joseph Fourier, CNRS/IN2P3/INPG, F-38026 Grenoble (France); Uggerhoj, U. I. [Department of Physics and Astronomy, University of Aarhus (Denmark)

    2013-04-15

    We report on the spin and diffractive physics at a future multi-purpose f xed-target experiment with proton and lead LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic f xed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER using typical targets would surpass that of RHIC by more than 3 orders of magnitude. The f xed-target mode has the advantage to allow for measurements of single-spin asymmetries with polarized target as well as of single-diffractive processes in the target region.

  17. Growing Fixed With Age: Lay Theories of Malleability Are Target Age-Specific.

    Science.gov (United States)

    Neel, Rebecca; Lassetter, Bethany

    2015-11-01

    Beliefs about whether people can change ("lay theories" of malleability) are known to have wide-ranging effects on social motivation, cognition, and judgment. Yet rather than holding an overarching belief that people can or cannot change, perceivers may hold independent beliefs about whether different people are malleable-that is, lay theories may be target-specific. Seven studies demonstrate that lay theories are target-specific with respect to age: Perceivers hold distinct, uncorrelated lay theories of people at different ages, and younger targets are considered to be more malleable than older targets. Both forms of target-specificity are consequential, as target age-specific lay theories predict policy support for learning-based senior services and the rehabilitation of old and young drug users. The implications of target age-specific lay theories for a number of psychological processes, the social psychology of aging, and theoretical frameworks of malleability beliefs are discussed. © 2015 by the Society for Personality and Social Psychology, Inc.

  18. Vision-Based Detection and Tracking of a Mobile Ground Target Using a Fixed-Wing UAV

    Directory of Open Access Journals (Sweden)

    Xun Wang

    2014-09-01

    Full Text Available This paper presents a framework for tracking a mobile ground target (MGT using a fixed-wing unmanned aerial vehicle (UAV. Challenges from pure theories to practical applications, including varying illumination, computational limits and a lack of clarity are considered. The procedure consists of four steps, namely: target detection, target localization, states estimation and UAV guidance. Firstly, the MGT in the wild is separated from the background using a Laplacian operator-based method. Next, the MGT is located by performing coordinate transformations with the assumption that the altitude of the ground is invariant and known. Afterwards, a Kalman filter is used to estimate the location and velocity of the MGT. Finally, a modified guidance law is developed to guide the UAV to circle and track the MGT. The performance of our framework is validated by simulations and a number of actual flight tests. The results indicate that the framework is effective and of low computational complexity, and in particular our modified guidance law can reduce the error of the tracking distance by about 75% in specified situations. With the proposed framework, such challenges caused by the actual system can be tackled effectively, and the fixed-wing UAV can track the MGT stably.

  19. Color-Coded Super-Resolution Small-Molecule Imaging.

    Science.gov (United States)

    Beuzer, Paolo; La Clair, James J; Cang, Hu

    2016-06-02

    Although the development of super-resolution microscopy dates back to 1994, its applications have been primarily focused on visualizing cellular structures and targets, including proteins, DNA and sugars. We now report on a system that allows both monitoring of the localization of exogenous small molecules in live cells at low resolution and subsequent super-resolution imaging by using stochastic optical reconstruction microscopy (STORM) on fixed cells. This represents a powerful new tool to understand the dynamics of subcellular trafficking associated with the mode and mechanism of action of exogenous small molecules.

  20. HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

    Science.gov (United States)

    Moens, Lotte N J; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; Sundström, Magnus; La Fleur, Linnéa; Mathot, Lucy; Micke, Patrick; Nilsson, Mats; Botling, Johan

    2015-11-01

    In recent years, the advent of massively parallel next-generation sequencing technologies has enabled substantial advances in the study of human diseases. Combined with targeted DNA enrichment methods, high sequence coverage can be obtained for different genes simultaneously at a reduced cost per sample, creating unique opportunities for clinical cancer diagnostics. However, the formalin-fixed, paraffin-embedded (FFPE) process of tissue samples, routinely used in pathology departments, results in DNA fragmentation and nucleotide modifications that introduce a number of technical challenges for downstream biomolecular analyses. We evaluated the HaloPlex target enrichment system for somatic mutation detection in 80 tissue fractions derived from 20 clinical cancer cases with paired tumor and normal tissue available in both FFPE and fresh-frozen format. Several modifications to the standard method were introduced, including a reduced target fragment length and two strand capturing. We found that FFPE material can be used for HaloPlex-based target enrichment and next-generation sequencing, even when starting from small amounts of DNA. By specifically capturing both strands for each target fragment, we were able to reduce the number of false-positive errors caused by FFPE-induced artifacts and lower the detection limit for somatic mutations. We believe that the HaloPlex method presented here will be broadly applicable as a tool for somatic mutation detection in clinical cancer settings.

  1. A framework to analyze searches for gauge bosons of the hidden light sector in electron scattering fixed target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Beranek, T. [Institut für Kernphysik, Johannes Gutenberg-Universität Mainz, D-55099 Mainz and PRISMA Cluster of Excellence, Johannes Gutenberg-Universität Mainz, D-55099 Mainz (Germany)

    2013-11-07

    Electron scattering fixed target experiments are a versatile tool to probe various kinds of physics phenomena. Recently fixed target experiments in which an electron beam is scattered off a heavy nucleus and a lepton-antilepton pair is created, i.e. e(A,Z) →e(A,Z)l{sup +}l{sup −}, were utilized to search for physics beyond the standard model at modest energies. In these experiments one searches for a small, narrow resonance in the invariant mass spectrum of the lepton-antilepton pair, arising from the exchange of a new light gauge boson γ′ coupling to the dark sector as well as very weakly to standard model particles. Such a signal would appear as an enhancement over a smooth QED background. Hence a precise understanding of the background is crucial. We present a theoretical analysis of the process e(A,Z) →e(A,Z)l{sup +}l{sup −}. Therefore we have performed an analysis of the cross section, which is then used to extract exclusion limits on the parameter space of the γ′, describing the existing experimental data taken at MAMI.

  2. Measurement of the Upsilon Production Cross Section in 920 GeV Fixed-Target Proton-Nucleus Collisions

    CERN Document Server

    Abt, I; Agari, M; Albrecht, H; Aleksandrov, A; Amaral, V S; Amorim, A; Aplin, S J; Aushev, V; Bagaturia, Yu S; Balagura, V; Bargiotti, M; Barsukova, O; Bastos, J; Batista, J; Bauer, C; Bauer, T S; Belkov, A; Belkov, Ar; Belotelov, I; Bertin, A; Bobchenko, B M; Böcker, M; Bogatyrev, A; Böhm, G; Brauer, M; Bruinsma, M; Bruschi, M; Buchholz, P; Buran, T; Carvalho, J; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deppe, H; Dong, X; Dreis, H B; Egorytchev, V; Ehret, K; Eisele, F; Emeliyanov, D; Essenov, S; Fabbri, L; Faccioli, P; Feuerstack-Raible, M; Flammer, J; Fominykh, B A; Funcke, M; Garrido, L; Gellrich, A; Giacobbe, B; Glass, J; Goloubkov, D; Golubkov, Y; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Grimaldi, F; Guilitsky, Yu; Hansen, J D; Hernández, J M; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W; Husemann, U; Igonkina, O; Ispiryan, M; Jagla, T; Jiang, C; Kapitza, H; Karabekyan, S; Karpenko, N; Keller, S; Kessler, J; Khasanov, F; Kiryushin, Yu T; Kisel, I; Klinkby, E; Knöpfle, K T; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kupper, S; Kvaratskheliia, T; Lanyov, A; Lau, K; Lewendel, B; Lohse, T; Lomonosov, B N; Männer, R; Mankel, R; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Mizuk, R; Muresan, R; Zur Nedden, M; Negodaev, M; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Ouchrif, M; Ould-Saada, F; Padilla, C; Peralta, D; Pernack, R; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, D; Prystupa, S; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Reeves, K; Ressing, D; Rick, H; Riu, I; Robmann, P; Rostovtseva, I; Rybnikov, V; Sánchez, F; Sbrizzi, A; Schmelling, M; Schmidt, B; Schreiner, A; Schröder, H; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Sciacca, F; Semprini-Cesari, N; Shuvalov, S; Silva, L; Sozuer, L; Solunin, S; Somov, A; Somov, S; Spengler, J; Spighi, R; Spiridonov, A A; Stanovnik, A; Staric, M; Stegmann, C; Subramanian, H S; Symalla, M; Tikhomirov, I; Titov, M; Tsakov, I; Uwer, U; Van Eldik, C; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wahlberg, H; Walenta, Albert H; Walter, M; Wang, J J; Wegener, D; Werthenbach, U; Wolters, H; Wurth, R; Wurz, A; Zaitsev, Yu; Zavertyaev, M V; Zeuner, T; Zhelezov, A; Zheng, Z; Zimmermann, R; Zivko, T; Zoccoli, A 002601701 700 L; Adler, S S; al, et

    2006-01-01

    The proton-nucleon cross section ratio $R=Br(\\Upsilon\\to l^+l^-) d\\sigma(\\Upsilon)/dy|_{y=0} / {\\sigma(J/\\psi)}$ has been measured with the HERA-B spectrometer in fixed-target proton-nucleus collisions at 920 GeV proton beam energy corresponding to a proton-nucleon cms energy of sqrt{s}=41.6 GeV. The combined results for the Upsilon decay channels Upsilon $\\to e^+e^-$ and Upsilon $\\to\\mu^+\\mu^-$ yield a ratio $R=(9.0 \\pm 2.1) 10^{-6}$. The corresponding Upsilon production cross section per nucleon at mid-rapidity (y=0) has been determined to be $Br(\\Upsilon\\to{}l^+l^-) {d\\sigma(\\Upsilon)/dy}|_{y=0}= 4.5 \\pm 1.1 $ pb/nucleon.

  3. A novel sampling method for multiple multiscale targets from scattering amplitudes at a fixed frequency

    Science.gov (United States)

    Liu, Xiaodong

    2017-08-01

    A sampling method by using scattering amplitude is proposed for shape and location reconstruction in inverse acoustic scattering problems. Only matrix multiplication is involved in the computation, thus the novel sampling method is very easy and simple to implement. With the help of the factorization of the far field operator, we establish an inf-criterion for characterization of underlying scatterers. This result is then used to give a lower bound of the proposed indicator functional for sampling points inside the scatterers. While for the sampling points outside the scatterers, we show that the indicator functional decays like the bessel functions as the sampling point goes away from the boundary of the scatterers. We also show that the proposed indicator functional continuously depends on the scattering amplitude, this further implies that the novel sampling method is extremely stable with respect to errors in the data. Different to the classical sampling method such as the linear sampling method or the factorization method, from the numerical point of view, the novel indicator takes its maximum near the boundary of the underlying target and decays like the bessel functions as the sampling points go away from the boundary. The numerical simulations also show that the proposed sampling method can deal with multiple multiscale case, even the different components are close to each other.

  4. Development of Detector Systems for Internal and Fixed Target Heavy Ion Physics Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Golubev, Pavel

    2003-04-01

    This thesis deals with intermediate energy heavy ion reactions with the particular aim to study the nuclear matter equation of state which defines the relation between statistical parameters of a fermionic system. The development of equipment for two experiments, CA47 at The Svedberg Laboratory in Uppsala, Sweden and R16 at Kernfysisch Versneller Inst. (KVI), Groningen, The Netherlands, are described. CA47 contains the CHICSi detector, a modular, ultra-high vacuum (UHV) compatible, multi-detector system, covering a solid angle of 3pi sr around the collision point. Together with two auxiliary detector systems CHICSi is placed at the cluster-jet target chamber of the CELSIUS storage ring. This thesis gives a technical overview of the detector and the development carried out in order to achieve the desired detection performance. Some laboratory and in-beam tests are described and the analysis of the first experimental results is discussed. The nuclear intensity interferometry experiment (R16) was performed in a dedicated beam-line of the AGOR superconducting cyclotron. Small-angle two-particle correlations were measured for the E/A = 61 MeV {sup 36}Ar + {sup 27}Al, {sup 112}Sn, {sup 124}Sn reactions, together with singles spectra. The experimental energy distributions of neutrons and light charged particles for the {sup 36}Ar + {sup 27}Al reaction have been analyzed with a Maxwellian multi-source prescription. These results, together with correlation function data, are used to extract information on the size of the emitting sources and their time evolution.

  5. Development of Detector Systems for Internal and Fixed Target Heavy Ion Physics Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Golubev, Pavel

    2003-04-01

    This thesis deals with intermediate energy heavy ion reactions with the particular aim to study the nuclear matter equation of state which defines the relation between statistical parameters of a fermionic system. The development of equipment for two experiments, CA47 at The Svedberg Laboratory in Uppsala, Sweden and R16 at Kernfysisch Versneller Inst. (KVI), Groningen, The Netherlands, are described. CA47 contains the CHICSi detector, a modular, ultra-high vacuum (UHV) compatible, multi-detector system, covering a solid angle of 3pi sr around the collision point. Together with two auxiliary detector systems CHICSi is placed at the cluster-jet target chamber of the CELSIUS storage ring. This thesis gives a technical overview of the detector and the development carried out in order to achieve the desired detection performance. Some laboratory and in-beam tests are described and the analysis of the first experimental results is discussed. The nuclear intensity interferometry experiment (R16) was performed in a dedicated beam-line of the AGOR superconducting cyclotron. Small-angle two-particle correlations were measured for the E/A = 61 MeV {sup 36}Ar + {sup 27}Al, {sup 112}Sn, {sup 124}Sn reactions, together with singles spectra. The experimental energy distributions of neutrons and light charged particles for the {sup 36}Ar + {sup 27}Al reaction have been analyzed with a Maxwellian multi-source prescription. These results, together with correlation function data, are used to extract information on the size of the emitting sources and their time evolution.

  6. Methane - quick fix or tough target? New methods to reduce emissions.

    Science.gov (United States)

    Nisbet, E. G.; Lowry, D.; Fisher, R. E.; Brownlow, R.

    2016-12-01

    Methane is a cost-effective target for greenhouse gas reduction efforts. The UK's MOYA project is designed to improve understanding of the global methane budget and to point to new methods to reduce future emissions. Since 2007, methane has been increasing rapidly: in 2014 and 2015 growth was at rates last seen in the 1980s. Unlike 20thcentury growth, primarily driven by fossil fuel emissions in northern industrial nations, isotopic evidence implies present growth is driven by tropical biogenic sources such as wetlands and agriculture. Discovering why methane is rising is important. Schaefer et al. (Science, 2016) pointed out the potential clash between methane reduction efforts and food needs of a rising, better-fed (physically larger) human population. Our own work suggests tropical wetlands are major drivers of growth, responding to weather changes since 2007, but there is no acceptable way to reduce wetland emission. Just as sea ice decline indicates Arctic warming, methane may be the most obvious tracker of climate change in the wet tropics. Technical advances in instrumentation can do much in helping cut urban and industrial methane emissions. Mobile systems can be mounted on vehicles, while drone sampling can provide a 3D view to locate sources. Urban land planning often means large but different point sources are typically clustered (e.g. landfill or sewage plant near incinerator; gas wells next to cattle). High-precision grab-sample isotopic characterisation, using Keeling plots, can separate source signals, to identify specific emitters, even where they are closely juxtaposed. Our mobile campaigns in the UK, Kuwait, Hong Kong and E. Australia show the importance of major single sources, such as abandoned old wells, pipe leaks, or unregulated landfills. If such point sources can be individually identified, even when clustered, they will allow effective reduction efforts to occur: these can be profitable and/or improve industrial safety, for example in the

  7. Session 4: Bio-diesel fuel (BDF) production by the trans-esterification of soybean and castor oils and the esterification of fatty acid using fixed bed reactor with solid super-acid and amorphous zirconia catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Satoshi, Furuta; Kyoji, Yano [Petroleum Refining Research and Technology Center, Japan Energy Corporation Niizo-minami, Toda, Saitama (Japan); Hiromi, Matsuhashi; Kazushi, Arata [Hokkaido University of Education, Dept. of Science, Hakodate (Japan)

    2004-07-01

    The monoesters produced by trans-esterification of vegetable oils with alcohol are known as bio-diesel fuel. Most of the bio-diesel fuels are currently made using alkaline catalysts, because the trans-esterification reaction by homogeneous acid catalysts are much slower than that by alkaline catalysts. There are several comprehensive studies of base catalyzed transesterification. The alkaline catalysts show high performance for obtaining vegetable oils with high quality, but a question often arises; that is, the oils contain significant amounts of free fatty acids, which cannot be converted into bio-diesels but to a lot of soap. As for solid catalysts, the uses of acid catalysts are quite few in contrast to solid bases. It appears that solid super-acids promote the trans-esterification of vegetable oils as well as the esterification of free fatty acids. Sulfated zirconia (SO{sub 4}/ZrO{sub 2}: SZA) and tungstate zirconia (WO{sub 3}/ZrO{sub 2}: WZA) are typical examples of those super acids and exhibit high catalytic activities for various reactions. Sulfated tin oxide (SO{sub 4}/SnO{sub 2}: STO) is one of the candidates with strong acidity on the surface. It has been reported that the acid strength is higher than that of SZ. This study was aimed to apply three types of solid super-acid catalysts and two types of amorphous zirconia catalysts to the transesterification of soybean oil and the esterification of normal octanoic acid with methanol. We also found that amorphous zirconia, doped with Al and Ti (Al/Zr, Ti/Zr), show high activities for the transesterification. The trans-esterification reaction was conducted in a fixed-bed once-through reactor with 4.0 g of catalyst. Methanol (4.4 g/h) and soybean oil (3.0 g/h), 40 in the molar ratio, were supplied to the reactor for 21 hrs. All catalysts showed little deactivation with time for WZA as an example. WZA together with amorphous zirconia, Al/Zr and Ti/Zr, showed quite high performance for the trans

  8. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma.

    Directory of Open Access Journals (Sweden)

    Andrew D Kelly

    Full Text Available The relatively new field of onco-metabolomics attempts to identify relationships between various cancer phenotypes and global metabolite content. Previous metabolomics studies utilized either nuclear magnetic resonance spectroscopy or gas chromatography/mass spectrometry, and analyzed metabolites present in urine and serum. However, direct metabolomic assessment of tumor tissues is important for determining altered metabolism in cancers. In this respect, the ability to obtain reliable data from archival specimens is desirable and has not been reported to date. In this feasibility study, we demonstrate the analysis of polar metabolites extracted directly from ten formalin-fixed, paraffin-embedded (FFPE specimens, including five soft tissue sarcomas and five paired normal samples. Using targeted liquid chromatography-tandem mass spectrometry (LC/MS/MS via selected reaction monitoring (SRM, we detect an average of 106 metabolites across the samples with excellent reproducibility and correlation between different sections of the same specimen. Unsupervised hierarchical clustering and principal components analysis reliably recovers a priori known tumor and normal tissue phenotypes, and supervised analysis identifies candidate metabolic markers supported by the literature. In addition, we find that diverse biochemical processes are well-represented in the list of detected metabolites. Our study supports the notion that reliable and broadly informative metabolomic data may be acquired from FFPE soft tissue sarcoma specimens, a finding that is likely to be extended to other malignancies.

  9. Interaction of Super Proton Synchrotron beam with solid copper target: Simulations of future experiments at HiRadMat facility at CERN

    CERN Document Server

    Tahir, N A; Brugger, M; Assmann, R; Shutov, A; Lomonosov, I V; Fortov, V E; Piriz, A R; Deutsch, C; Hoffmann, D H H

    2009-01-01

    In this paper we present numerical simulations of interaction of 450 GeV/c proton beam that is generated by Super Proton Synchrotron (SPS) at CERN, with a solid copper target. These simulations have been carried out using a two-dimensional hydrodynamic computer code, BIG2. This study has been done to assess the damage caused by these highly relativistic protons to equipment including collimators, absorbers and others in case of an uncontrolled accidental release of the beam. In fact a dedicated experimental facility named HiRadMat is under construction at CERN that will allow one to study these problems experimentally. The simulations presented in this paper will be very useful in designing these experiments and later to interpret the experimental results.

  10. Super Special Codes using Super Matrices

    CERN Document Server

    Kandasamy, W B Vasantha; Ilanthenral, K

    2010-01-01

    The new classes of super special codes are constructed in this book using the specially constructed super special vector spaces. These codes mainly use the super matrices. These codes can be realized as a special type of concatenated codes. This book has four chapters. In chapter one basic properties of codes and super matrices are given. A new type of super special vector space is constructed in chapter two of this book. Three new classes of super special codes namely, super special row code, super special column code and super special codes are introduced in chapter three. Applications of these codes are given in the final chapter.

  11. Interactive Segmentation of Airport Target via Super-pixel%超像素在机场跑道图像分割中的应用研究

    Institute of Scientific and Technical Information of China (English)

    杨海龙; 王富强

    2016-01-01

    The research on SAR image segmentation of airport runway is great significance. In this paper, image segmentation of the airport targets was realized, taking reducing the initial point number of participate in iteration as the breakthrough point to accelerate the optimization process of the Meanshift calculation, dividing the original image into several super-pixels with the good homogeneity, and then setting up the appropriate mathematical model. The experimental results show that this method can improve the speed of the segmentation and at the same time can effectively guarantee the accuracy and integrity of airport target segmentation.%机场跑道分割在SAR图像处理研究中有着重要意义。本文通过减少参与迭代的初始点数量为切入点来对均值漂移过程进行加速,将原始图像分割成若干同质性良好的超像素,再建立适当的数学模型,实现对机场目标的分割。实验表明,该方法在提高分割速度的同时,有效提高了分割结果的精确性和完整性。

  12. Super Factories

    Indian Academy of Sciences (India)

    D G Hitlin

    2006-11-01

    Heavy-flavor physics, in particular and physics results from the factories, currently provides strong constraints on models of physics beyond the Standard Model. A new generation of colliders, Super Factories, with 50 to 100 times the luminosity of existing colliders, can, in a dialog with LHC and ILC, provide unique clarification of new physics phenomena seen at those machines.

  13. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    CERN Document Server

    Tahir, N A; Shutov, A; Schmidt, R; Piriz, A R

    2012-01-01

    The Large Hadron Collider (LHC) is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding...

  14. The Super Patalan Numbers

    OpenAIRE

    Richardson, Thomas M.

    2014-01-01

    We introduce the super Patalan numbers, a generalization of the super Catalan numbers in the sense of Gessel, and prove a number of properties analagous to those of the super Catalan numbers. The super Patalan numbers generalize the super Catalan numbers similarly to how the Patalan numbers generalize the Catalan numbers.

  15. Membrane targeting of MnSOD is essential for oxidative stress tolerance of nitrogen-fixing cultures of Anabaena sp. strain PCC7120.

    Science.gov (United States)

    Raghavan, Prashanth S; Rajaram, Hema; Apte, Shree Kumar

    2015-07-01

    The nitrogen-fixing cyanobacterium, Anabaena PCC7120 encodes for a membrane-targeted 30 kDa Mn-superoxide dismutase (MnSOD) and a cytosolic FeSOD. The MnSOD is post-translationally processed to 27 and 24 kDa forms in the cytosol and periplasm/thylakoid lumen. The extent of cleavage of signal and linker peptides at the N-terminus is dependent on the availability of combined nitrogen during growth. While the 24 and 27 kDa forms are present in near equal proportions under nitrogen-fixing conditions, the 24 kDa form is predominant under nitrogen-supplemented conditions. Individual contribution of these forms of MnSOD to total oxidative stress tolerance was analysed using recombinant Anabaena strains overexpressing either different molecular forms of MnSOD or MnSOD defective in the cleavage of signal/linker peptide. Targeting of MnSOD to the membrane and subsequent cleavage to release both the 24 and 27 kDa forms was essential for oxidative stress tolerance under nitrogen-fixing conditions. On the other hand, the cleavage of linker peptide was absolutely essential and the release of cytosolic 24 kDa form of MnSOD was obligatory for developing oxidative stress tolerance under nitrogen-supplemented conditions. Thus, a single MnSOD caters to the reduction of superoxide radical in both cytosol and thylakoid lumen/periplasm irrespective of the N-status of growth by regulating its cleavage. This is the first report on the physiological advantage of membrane-targeting and processing of MnSOD in either bacteria or plants. The higher oxidative stress tolerance offered by the cytosolic form of MnSOD has possibly resulted in retention of only the cytosolic form in bacterial non-nitrogen-fixers during evolution.

  16. Benchmarking of Proton Transport in Super Monte Carlo Simulation Program

    Science.gov (United States)

    Wang, Yongfeng; Li, Gui; Song, Jing; Zheng, Huaqing; Sun, Guangyao; Hao, Lijuan; Wu, Yican

    2014-06-01

    The Monte Carlo (MC) method has been traditionally applied in nuclear design and analysis due to its capability of dealing with complicated geometries and multi-dimensional physics problems as well as obtaining accurate results. The Super Monte Carlo Simulation Program (SuperMC) is developed by FDS Team in China for fusion, fission, and other nuclear applications. The simulations of radiation transport, isotope burn-up, material activation, radiation dose, and biology damage could be performed using SuperMC. Complicated geometries and the whole physical process of various types of particles in broad energy scale can be well handled. Bi-directional automatic conversion between general CAD models and full-formed input files of SuperMC is supported by MCAM, which is a CAD/image-based automatic modeling program for neutronics and radiation transport simulation. Mixed visualization of dynamical 3D dataset and geometry model is supported by RVIS, which is a nuclear radiation virtual simulation and assessment system. Continuous-energy cross section data from hybrid evaluated nuclear data library HENDL are utilized to support simulation. Neutronic fixed source and critical design parameters calculates for reactors of complex geometry and material distribution based on the transport of neutron and photon have been achieved in our former version of SuperMC. Recently, the proton transport has also been intergrated in SuperMC in the energy region up to 10 GeV. The physical processes considered for proton transport include electromagnetic processes and hadronic processes. The electromagnetic processes include ionization, multiple scattering, bremsstrahlung, and pair production processes. Public evaluated data from HENDL are used in some electromagnetic processes. In hadronic physics, the Bertini intra-nuclear cascade model with exitons, preequilibrium model, nucleus explosion model, fission model, and evaporation model are incorporated to treat the intermediate energy nuclear

  17. Single-Transverse-Spin-Asymmetry studies with a fixed-target experiment using the LHC beams (AFTER@LHC)

    CERN Document Server

    Lansberg, J P; Arnaldi, R; Brodsky, S J; Chambert, V; Da Silva, C; Didelez, J P; Echevarria, M G; Ferreiro, E G; Fleuret, F; Gao, Y; Genolini, B; Hadjidakis, C; Hřivnáčová, I; Kikola, D; Klein, A; Kurepin, A; Kusina, A; Lorcé, C; Lyonnet, F; Massacrier, L; Nass, A; Pisano, C; Robbe, P; Schienbein, I; Schlegel, M; Scomparin, E; Seixas, J; Shao, H S; Signori, A; Steffens, E; Topilskaya, N; Trzeciak, B; Uggerhøj, U I; Uras, A; Ulrich, R; Yang, Z

    2016-01-01

    We discuss the potential of AFTER@LHC to measure single-transverse-spin asymmetries in open-charm and bottomonium production. With a HERMES-like hydrogen polarised target, such measurements over a year can reach precisions close to the per cent level. This is particularly remarkable since these analyses can probably not be carried out anywhere else

  18. Beam-Induced Effects and Radiological Issues in High-Intensity High-Energy Fixed Target Experiments

    CERN Document Server

    Mokhov, N V; Drozhdin, A I; Pronskikh, V S; Reitzner, D; Tropin, I S; Vaziri, K

    2014-01-01

    The next generation of accelerators for Megawatt proton and heavy-ion beams moves us into a completely new domain of extreme specific energies of up to 0.1 MJ/g (Megajoule/gram) and specific power up to 1 TW/g (Terawatt/gram) in beam interactions with matter. This paper is focused on deleterious effects of controlled and uncontrolled impacts of high-intensity beams on components of beam-lines, target stations, beam absorbers, shielding and environment. Two new experiments at Fermilab are taken as an example. The Long-Baseline Neutrino Experiment (LBNE) will explore the interactions and transformations of the world's highest-intensity neutrino beam by sending it from Fermilab more than 1,000 kilometers through the Earth's mantle to a large liquid argon detector. The Mu2e experiment is devoted to studies of the conversion of a negative muon to electron in the field of a nucleus without emission of neutrinos.

  19. Production of High-Mass Pairs of Direct Photons and Neutral Mesons in a Tevatron Fixed-Target Experiment

    CERN Document Server

    Begel, M

    1999-01-01

    The production of high-mass pairs of direct photons, π 0's, and η's has been measured by Fermilab experiment E706. The experimental apparatus included a large, finely segmented lead-liquid argon electromagnetic calorimeter and a charged particle spectrometer consisting of silicon microstrip detectors in the target region and multiwire proportional chambers and straw tube drift chambers downstream of an analysis magnet. The experiment triggered on localized high- pT depositions in the electromagnetic calorimeter; the high-mass pair data required two depositions on opposite sides of the calorimeter. Correlations between high-pT particles are used to extract information about the transverse momentum of partons (k T). Comparisons are made between the diphoton data and the results of next-to-leading order perturbative Quantum Chromodynamic (NLO pQCD) calculations. The shapes of the NLO pQCD results are inconsistent with the data distributions. A resummed NLO pQCD calculation, which incorporates the ...

  20. Polarization of Lambda and Anti-Lambda in 920 GeV Fixed-Target Proton-Nucleus Collisions

    CERN Document Server

    Abt, I; Agari, M; Albrecht, H; Aleksandrov, A; Amaral, V S; Amorim, A; Aplin, S J; Aushev, V; Bagaturia, Yu S; Balagura, V; Bargiotti, M; Barsukova, O; Bastos, J; Batista, J; Bauer, C; Bauer, T S; Belkov, A; Belkov, Ar; Belotelov, I; Bertin, A; Bobchenko, B M; Böcker, M; Bogatyrev, A; Böhm, G; Brauer, M; Bruinsma, M; Bruschi, M; Buchholz, P; Buran, T; Carvalho, J; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deppe, H; Dong, X; Dreis, H B; Egorytchev, V; Ehret, K; Eisele, F; Emeliyanov, D; Erhan, S; Essenov, S; Fabbri, L; Faccioli, P; Feuerstack-Raible, M; Flammer, J; Fominykh, B A; Funcke, M; Garrido, L; Gellrich, A; Giacobbe, B; Glass, J; Goloubkov, D; Golubkov, Y; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Grimaldi, F; Guilitsky, Yu; Hansen, J D; Hernández, J M; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W; Husemann, U; Igonkina, O; Ispiryan, M; Jagla, T; Jiang, C; Kapitza, H; Karabekyan, S; Karpenko, N; Keller, S; Kessler, J; Khasanov, F; Kiryushin, Yu T; Kisel, I; Klinkby, E; Knöpfle, K T; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kupper, S; Kvaratskheliia, T; Lanyov, A; Lau, K; Lewendel, B; Lohse, T; Lomonosov, B N; Männer, R; Mankel, R; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Mizuk, R; Muresan, R; Zur Nedden, M; Negodaev, M; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Ouchrif, M; Ould-Saada, F; Padilla, C; Peralta, D; Pernack, R; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, D; Prystupa, S; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Reeves, K; Ressing, D; Rick, H; Riu, I; Robmann, P; Rostovtseva, I; Rybnikov, V; Sánchez, F; Sbrizzi, A; Schmelling, M; Schmidt, B; Schreiner, A; Schröder, H; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Sciacca, F; Semprini-Cesari, N; Shuvalov, S; Silva, L; Sozuer, L; Solunin, S; Somov, A; Somov, S; Spengler, J; Spighi, R; Spiridonov, A A; Stanovnik, A; Staric, M; Stegmann, C; Subramanian, H S; Symalla, M; Tikhomirov, I; Titov, M; Tsakov, I; Uwer, U; Van Eldik, C; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wahlberg, H; Walenta, Albert H; Walter, M; Wang, J J; Wegener, D; Werthenbach, U; Wolters, H; Wurth, R; Wurz, A; Zaitsev, Yu; Zavertyaev, M V; Zeuner, T; Zhelezov, A; Zheng, Z; Zimmermann, R; Zivko, T; Zoccoli, A

    2006-01-01

    A measurement of the polarization of Lambda and Anti-Lambda baryons produced in pC and pW collisions at sqrt(s)=41.6 GeV has been performed with the HERA-B spectrometer. The measurements cover the kinematic range of 0.6 GeV/c < p_T<1.2 GeV/c in transverse momentum and -0.15targets agree within the statistical error. In the combined data set, the largest deviation from zero, +0.054 +- 0.029, is measured for x_F < -0.07. Zero polarization is expected at x_F=0 in the absence of nuclear effects. The polarization results for the Lambda agree with a parametrization of previous measurements which were performed at positive x_F values, where the Lambda polarization is negative. Results of Anti-Lambda polarization measurements are consistent with zero.

  1. Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

    Directory of Open Access Journals (Sweden)

    Wendy W J de Leng

    Full Text Available Targeted Next Generation Sequencing (NGS offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have been defined. This study therefore aimed to determine the effect of the type of input material (e.g. formalin fixed paraffin embedded (FFPE versus fresh frozen (FF tissue on NGS derived results. Moreover, this study aimed to explore a standardized analysis pipeline to support consistent clinical decision-making.We used the Ion Torrent PGM sequencing platform in combination with the Ion AmpliSeq Cancer Hotspot Panel v2 to sequence frequently mutated regions in 50 cancer related genes, and validated the NGS detected variants in 250 FFPE samples using standard diagnostic assays. Next, 386 tumour samples were sequenced to explore the effect of input material on variant detection variables. For variant calling, Ion Torrent analysis software was supplemented with additional variant annotation and filtering.Both FFPE and FF tissue could be sequenced reliably with a sensitivity of 99.1%. Validation showed a 98.5% concordance between NGS and conventional sequencing techniques, where NGS provided both the advantage of low input DNA concentration and the detection of low-frequency variants. The reliability of mutation analysis could be further improved with manual inspection of sequence data.Targeted NGS can be reliably implemented in cancer diagnostics using both FFPE and FF tissue when using appropriate analysis settings, even with low input DNA.

  2. Study of an Impact-Parameter Optical Discriminator to be used for Beauty Search in Fixed-Target Mode~ at~the~LHC

    CERN Multimedia

    2002-01-01

    % RD30 \\\\ \\\\ We propose a research and development of an $^{\\prime}$Optical Trigger$^{\\prime}$ to be used for B-meson selection in a LHC fixed-target experiment. The optical trigger relies on the detection of Cerenkov light produced and trapped in a thin spherical crystal viewed by a fast photodetector. The device is, in principle, sensitive to charged particles with large impact parameter arising from secondary vertices belonging to the B-meson chain, but it is blind to minimum bias events originating in a small target. A full prototype using LiF fluoride crystal in 1992 and the experimental results are in agreement with expectations. Backgrounds due to delta-rays and nuclear interactions are measured to be about 2\\%. A second generation prototype with Sapphire crystal and liquid cladding is developed to improve the sensitivity of the device at very low impact parameters (100~$\\mu$m). A third generation prototype with fiber read-out is also under preparation. To improve further the sensitivity a novel read-o...

  3. Profiling cancer gene mutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing.

    Science.gov (United States)

    Zhang, Liangxuan; Chen, Liangjing; Sah, Sachin; Latham, Gary J; Patel, Rajesh; Song, Qinghua; Koeppen, Hartmut; Tam, Rachel; Schleifman, Erica; Mashhedi, Haider; Chalasani, Sreedevi; Fu, Ling; Sumiyoshi, Teiko; Raja, Rajiv; Forrest, William; Hampton, Garret M; Lackner, Mark R; Hegde, Priti; Jia, Shidong

    2014-04-01

    The success of precision oncology relies on accurate and sensitive molecular profiling. The Ion AmpliSeq Cancer Panel, a targeted enrichment method for next-generation sequencing (NGS) using the Ion Torrent platform, provides a fast, easy, and cost-effective sequencing workflow for detecting genomic "hotspot" regions that are frequently mutated in human cancer genes. Most recently, the U.K. has launched the AmpliSeq sequencing test in its National Health Service. This study aimed to evaluate the clinical application of the AmpliSeq methodology. We used 10 ng of genomic DNA from formalin-fixed, paraffin-embedded human colorectal cancer (CRC) tumor specimens to sequence 46 cancer genes using the AmpliSeq platform. In a validation study, we developed an orthogonal NGS-based resequencing approach (SimpliSeq) to assess the AmpliSeq variant calls. Validated mutational analyses revealed that AmpliSeq was effective in profiling gene mutations, and that the method correctly pinpointed "true-positive" gene mutations with variant frequency >5% and demonstrated high-level molecular heterogeneity in CRC. However, AmpliSeq enrichment and NGS also produced several recurrent "false-positive" calls in clinically druggable oncogenes such as PIK3CA. AmpliSeq provided highly sensitive and quantitative mutation detection for most of the genes on its cancer panel using limited DNA quantities from formalin-fixed, paraffin-embedded samples. For those genes with recurrent "false-positive" variant calls, caution should be used in data interpretation, and orthogonal verification of mutations is recommended for clinical decision making.

  4. Fix 40!

    Index Scriptorium Estoniae

    2008-01-01

    Ansambel Fix peab 13. detsembril Tallinnas Saku Suurhallis oma 40. sünnipäeva. Kontserdi erikülaline on ansambel Apelsin, kaastegevad Jassi Zahharov ja HaleBopp Singers. Õhtut juhib Tarmo Leinatamm

  5. Fix 40!

    Index Scriptorium Estoniae

    2008-01-01

    Ansambel Fix peab 13. detsembril Tallinnas Saku Suurhallis oma 40. sünnipäeva. Kontserdi erikülaline on ansambel Apelsin, kaastegevad Jassi Zahharov ja HaleBopp Singers. Õhtut juhib Tarmo Leinatamm

  6. Chromosomal aberrations in bladder cancer: fresh versus formalin fixed paraffin embedded tissue and targeted FISH versus wide microarray-based CGH analysis.

    Directory of Open Access Journals (Sweden)

    Elena Panzeri

    Full Text Available Bladder carcinogenesis is believed to follow two alternative pathways driven by the loss of chromosome 9 and the gain of chromosome 7, albeit other nonrandom copy number alterations (CNAs were identified. However, confirmation studies are needed since many aspects of this model remain unclear and considerable heterogeneity among cases has emerged. One of the purposes of this study was to evaluate the performance of a targeted test (UroVysion assay widely used for the detection of Transitional Cell Carcinoma (TCC of the bladder, in two different types of material derived from the same tumor. We compared the results of UroVysion test performed on Freshly Isolated interphasic Nuclei (FIN and on Formalin Fixed Paraffin Embedded (FFPE tissues from 22 TCCs and we didn't find substantial differences. A second goal was to assess the concordance between array-CGH profiles and the targeted chromosomal profiles of UroVysion assay on an additional set of 10 TCCs, in order to evaluate whether UroVysion is an adequately sensitive method for the identification of selected aneuploidies and nonrandom CNAs in TCCs. Our results confirmed the importance of global genomic screening methods, that is array based CGH, to comprehensively determine the genomic profiles of large series of TCCs tumors. However, this technique has yet some limitations, such as not being able to detect low level mosaicism, or not detecting any change in the number of copies for a kind of compensatory effect due to the presence of high cellular heterogeneity. Thus, it is still advisable to use complementary techniques such as array-CGH and FISH, as the former is able to detect alterations at the genome level not excluding any chromosome, but the latter is able to maintain the individual data at the level of single cells, even if it focuses on few genomic regions.

  7. Microarray gene expression analysis of fixed archival tissue permits molecular classification and identification of potential therapeutic targets in diffuse large B-cell lymphoma.

    Science.gov (United States)

    Linton, Kim; Howarth, Christopher; Wappett, Mark; Newton, Gillian; Lachel, Cynthia; Iqbal, Javeed; Pepper, Stuart; Byers, Richard; Chan, Wing John; Radford, John

    2012-01-01

    Refractory/relapsed diffuse large B-cell lymphoma (DLBCL) has a poor prognosis. Novel drugs targeting the constitutively activated NF-κB pathway characteristic of ABC-DLBCL are promising, but evaluation depends on accurate activated B cell-like (ABC)/germinal center B cell-like (GCB) molecular classification. This is traditionally performed on gene microarray expression profiles of fresh biopsies, which are not routinely collected, or by immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tissue, which lacks reproducibility and classification accuracy. We explored the possibility of using routine archival FFPE tissue for gene microarray applications. We examined Affymetrix HG U133 Plus 2.0 gene expression profiles from paired archival FFPE and fresh-frozen tissues of 40 ABC/GCB-classified DLBCL cases to compare classification accuracy and test the potential for this approach to aid the discovery of therapeutic targets and disease classifiers in DLBCL. Unsupervised hierarchical clustering of unselected present probe sets distinguished ABC/GCB in FFPE with remarkable accuracy, and a Bayesian classifier correctly assigned 32 of 36 cases with >90% probability. Enrichment for NF-κB genes was appropriately seen in ABC-DLBCL FFPE tissues. The top discriminatory genes expressed in FFPE separated cases with high statistical significance and contained novel biology with potential therapeutic insights, warranting further investigation. These results support a growing understanding that archival FFPE tissues can be used in microarray experiments aimed at molecular classification, prognostic biomarker discovery, and molecular exploration of rare diseases. Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  8. Feasibility studies for quarkonium production at a fixed-target experiment using the LHC proton and lead beams (AFTER@LHC)

    CERN Document Server

    Massacrier, L; Fleuret, F; Hadjidakis, C; Kikola, D; Lansberg, J P; Shao, H -S

    2015-01-01

    Used in the fixed-target mode, the multi-TeV LHC proton and lead beams allow for studies of heavy-flavour hadroproduction with unprecedented precision at backward rapidities - far negative Feyman-x - using conventional detection techniques. At the nominal LHC energies, quarkonia can be studies in detail in p+p, p+d and p+A collisions at sqrt(s_NN) ~ 115 GeV as well as in Pb+p and Pb+A collisions at sqrt(s_NN) ~ 72 GeV with luminosities roughly equivalent to that of the collider mode, i.e. up to 20 fb-1 yr-1 in p+p and p+d collisions, up to 0.6 fb-1 yr-1 in p+A collisions and up to 10 nb-1 yr-1 in Pb+A collisions. In this paper, we assess the feasibility of such studies by performing fast simulations using the performance of a LHCb-like detector.

  9. Feasibility Studies for Quarkonium Production at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC

    Directory of Open Access Journals (Sweden)

    L. Massacrier

    2015-01-01

    Full Text Available Being used in the fixed-target mode, the multi-TeV LHC proton and lead beams allow for studies of heavy-flavour hadroproduction with unprecedented precision at backward rapidities, far negative Feynman-x, using conventional detection techniques. At the nominal LHC energies, quarkonia can be studied in detail in p+p, p+d, and p+A collisions at sNN≃115 GeV and in Pb + p and Pb + A collisions at sNN≃72 GeV with luminosities roughly equivalent to that of the collider mode that is up to 20 fb−1 yr−1 in p+p and p+d collisions, up to 0.6 fb−1 yr−1 in p+A collisions, and up to 10 nb−1 yr−1 in Pb + A collisions. In this paper, we assess the feasibility of such studies by performing fast simulations using the performance of a LHCb-like detector.

  10. Targeted, high-depth, next-generation sequencing of cancer genes in formalin-fixed, paraffin-embedded and fine-needle aspiration tumor specimens.

    Science.gov (United States)

    Hadd, Andrew G; Houghton, Jeff; Choudhary, Ashish; Sah, Sachin; Chen, Liangjing; Marko, Adam C; Sanford, Tiffany; Buddavarapu, Kalyan; Krosting, Julie; Garmire, Lana; Wylie, Dennis; Shinde, Rupali; Beaudenon, Sylvie; Alexander, Erik K; Mambo, Elizabeth; Adai, Alex T; Latham, Gary J

    2013-03-01

    Implementation of highly sophisticated technologies, such as next-generation sequencing (NGS), into routine clinical practice requires compatibility with common tumor biopsy types, such as formalin-fixed, paraffin-embedded (FFPE) and fine-needle aspiration specimens, and validation metrics for platforms, controls, and data analysis pipelines. In this study, a two-step PCR enrichment workflow was used to assess 540 known cancer-relevant variants in 16 oncogenes for high-depth sequencing in tumor samples on either mature (Illumina GAIIx) or emerging (Ion Torrent PGM) NGS platforms. The results revealed that the background noise of variant detection was elevated approximately twofold in FFPE compared with cell line DNA. Bioinformatic algorithms were optimized to accommodate this background. Variant calls from 38 residual clinical colorectal cancer FFPE specimens and 10 thyroid fine-needle aspiration specimens were compared across multiple cancer genes, resulting in an accuracy of 96.1% (95% CI, 96.1% to 99.3%) compared with Sanger sequencing, and 99.6% (95% CI, 97.9% to 99.9%) compared with an alternative method with an analytical sensitivity of 1% mutation detection. A total of 45 of 48 samples were concordant between NGS platforms across all matched regions, with the three discordant calls each represented at <10% of reads. Consequently, NGS of targeted oncogenes in real-life tumor specimens using distinct platforms addresses unmet needs for unbiased and highly sensitive mutation detection and can accelerate both basic and clinical cancer research.

  11. Super-Eccentric Migrating Jupiters

    CERN Document Server

    Socrates, Aristotle; Dong, Subo; Tremaine, Scott

    2011-01-01

    An important class of formation theories for hot Jupiters involves the excitation of extreme orbital eccentricity (e=0.99 or even larger) followed by tidal dissipation at periastron passage that eventually circularizes the planetary orbit at a period less than 10 days. In a steady state, this mechanism requires the existence of a significant population of super-eccentric (e>0.9) migrating Jupiters with long orbital periods and periastron distances of only a few stellar radii. For these super-eccentric planets, the periastron is fixed due to conservation of orbital angular momentum and the energy dissipated per orbit is constant, implying that the rate of change in semi-major axis a is \\dot a \\propto a^0.5 and consequently the number distribution satisfies dN/dlog a\\propto a^0.5. If this formation process produces most hot Jupiters, Kepler should detect several super-eccentric migrating progenitors of hot Jupiters, allowing for a test of high-eccentricity migration scenarios.

  12. SUPER-ECCENTRIC MIGRATING JUPITERS

    Energy Technology Data Exchange (ETDEWEB)

    Socrates, Aristotle; Katz, Boaz; Dong Subo; Tremaine, Scott [Institute for Advanced Study, Princeton, NJ 08540 (United States)

    2012-05-10

    An important class of formation theories for hot Jupiters involves the excitation of extreme orbital eccentricity (e = 0.99 or even larger) followed by tidal dissipation at periastron passage that eventually circularizes the planetary orbit at a period less than 10 days. In a steady state, this mechanism requires the existence of a significant population of super-eccentric (e > 0.9) migrating Jupiters with long orbital periods and periastron distances of only a few stellar radii. For these super-eccentric planets, the periastron is fixed due to conservation of orbital angular momentum and the energy dissipated per orbit is constant, implying that the rate of change in semi-major axis a is a-dot {proportional_to}a{sup 1/2} and consequently the number distribution satisfies dN/d log a{proportional_to}a{sup 1/2}. If this formation process produces most hot Jupiters, Kepler should detect several super-eccentric migrating progenitors of hot Jupiters, allowing for a test of high-eccentricity migration scenarios.

  13. Production of the Doubly Heavy Baryons, $B_c$ meson and the Tetra-c-quark at the Fixed-target Experiment at the LHC with double intrinsic heavy approach

    CERN Document Server

    Koshkarev, Sergey

    2016-01-01

    In the paper we discuss production of the $B_c$ meson, the doubly heavy baryons and the tetra-c-quark at the future fixed-target experiment at the LHC (AFTER@LHC) with the doubly intrinsic heavy mechanism. The production cross sections are present.

  14. Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection.

    Science.gov (United States)

    Herai, Roberto R; Stefanacci, Lisa; Hrvoj-Mihic, Branka; Chailangkarn, Thanathom; Hanson, Kari; Semendeferi, Katerina; Muotri, Alysson R

    2014-09-30

    Formalin fixation (FF) is the standard and most common method for preserving postmortem brain tissue. FF stabilizes cellular morphology and tissue architecture, and can be used to study the distinct morphologic and genetic signatures of different cell types. Although the procedure involved in FF degrades messenger RNA over time, an alternative approach is to use small RNAs (sRNAs) for genetic analysis associated with cell morphology. Although genetic analysis is carried out on fresh or frozen tissue, there is limited availability or impossibility on targeting specific cell populations, respectively. The goal of this study is to detect miRNA and other classes of sRNA stored in formalin or in paraffin embedded for over decades. Two brain samples, one formed by a mixed population of cortical and subcortical cells, and one formed by pyramidal shaped cells collected by laser-capture microdissection, were subjected to sRNA sequencing. Performing bioinformatics analysis over the sequenced sRNA from brain tissue, we detected several classes of sRNA, such as miRNAs that play key roles in brain neurodevelopmental and maintenance pathways, and hsa-mir-155 expression in neurons. Comparison with existing method: Our method is the first to combine the approaches for: laser-capture of pyramidal neurons from long-term formalin-fixed brain; extract sRNA from laser-captured pyramidal neurons; apply a suite of bioinformatics tools to detect miRNA and other classes of sRNAs on sequenced samples having high levels of RNA degradation. This is the first study to show that sRNA can be rescued from laser-captured FF pyramidal neurons. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Super-resolution optical telescopes with local light diffraction shrinkage

    OpenAIRE

    Changtao Wang; Dongliang Tang; Yanqin Wang; Zeyu Zhao; Jiong Wang; Mingbo Pu; Yudong Zhang; Wei Yan; Ping Gao; Xiangang Luo

    2015-01-01

    Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinkage associated with optical super-oscillatory phenomenon is proposed for real-time and optically restoring super-resolution imaging information in a telescope system. It is found ...

  16. Calculus super review

    CERN Document Server

    2012-01-01

    Get all you need to know with Super Reviews! Each Super Review is packed with in-depth, student-friendly topic reviews that fully explain everything about the subject. The Calculus I Super Review includes a review of functions, limits, basic derivatives, the definite integral, combinations, and permutations. Take the Super Review quizzes to see how much you've learned - and where you need more study. Makes an excellent study aid and textbook companion. Great for self-study!DETAILS- From cover to cover, each in-depth topic review is easy-to-follow and easy-to-grasp - Perfect when preparing for

  17. Algebra & trigonometry super review

    CERN Document Server

    2012-01-01

    Get all you need to know with Super Reviews! Each Super Review is packed with in-depth, student-friendly topic reviews that fully explain everything about the subject. The Algebra and Trigonometry Super Review includes sets and set operations, number systems and fundamental algebraic laws and operations, exponents and radicals, polynomials and rational expressions, equations, linear equations and systems of linear equations, inequalities, relations and functions, quadratic equations, equations of higher order, ratios, proportions, and variations. Take the Super Review quizzes to see how much y

  18. Random Seismic Response Analysis of Super High-Rise Structure Based on Target Response Spectrum%基于目标反应谱的超高层结构随机地震反应分析

    Institute of Scientific and Technical Information of China (English)

    陈清军; 陈志海; 张振炫

    2012-01-01

    目前有关超高层结构的地震反应研究大多限于确定性问题.分别选用上海抗震设计反应谱和软土场地拟合反应谱作为目标反应谱,用迭代方法求取与目标反应谱相对应的功率谱密度函数,按Clough-Penzien平稳随机地震动模型拟合并给出相应谱参数,采用Ansys软件建立上海某超高层建筑结构的三维有限元分析模型,以文中拟合的平稳随机地震动功率谱密度作为输入,对超高层结构进行了随机地震反应分析,探讨了不同类型的随机地震作用下超高层建筑结构地震反应的差异、以及结构的功率谱反应随层高的变化情况,得到了有工程参考价值的结果.%At present, due to the lack of long-period ground motion records, the research results on seismic response characteristics of high-rise structures under random seismic input get quite few. The Shanghai earthquake design response spectrum and the fitting long-period response spectrum of soft soil site were chosen as target response spectrum, and the iterating method was used to compute the relative power spectral density functions. Then, the Clough-Penzien model was selected to fit the power spectral density functions, and corresponding spectral parameters were given. Based on this, the Ansys software was used to establish the three-dimensional finite element model of a super high-rise building located in Shanghai, and the random seismic response of the super high-rise structure was analyzed, the random seismic response characteristic of the super high-rise structure under different power spectral density and the response variation of floor power spectral density were discussed , and some valuable conclusions for engineering were acquired.

  19. Super Tomboy Style

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Sparked by Super Girl, the androgynous look is in among Chinese youth On September 8, this year's top six contestants on the Super Girl television show, a singing contest for young women, stepped into the spotlight. Nearly none of them had long black hair or wore evening gowns, traditionally associated with beauty in China. Rather, they

  20. Impact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleonImpact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleon

    Science.gov (United States)

    NA52 Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Hess, P.; Kabana, S.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Tuominiemi, J.; Weber, M.

    1999-12-01

    Nuclear matter is expected to undergo a phase transition to quark matter in ultrarelativistic heavy-ion collisions, possibly showing up as a discontinuity in the impact parameter dependence of relevant observables. Following this expectation, we have investigated the impact parameter dependence of the invariant yields of K+/-, p, d, pbar and dbar in the range ~ 2 - 12 fm in fixed-target Pb+Pb collisions at 158 GeV/nucleon incident energy at the CERN SPS. The particles have been measured near zero transverse momentum and in the rapidity range y = 3.1 - 4.4. In addition, the centrality dependence of the baryon chemical potential, the effective temperature and the size of the particle emitting source at freeze-out were studied. No dramatic change in the distribution of any of these variables is observed as a function of the impact parameter. The same is found for the particle yields, with the exception of the yield of charged kaons per number of nucleons participating in the collision (Np), where there is an indication of a threshold behaviour at Np~80.

  1. Nonlinear Super Integrable Couplings of Super Classical-Boussinesq Hierarchy

    Directory of Open Access Journals (Sweden)

    Xiuzhi Xing

    2014-01-01

    Full Text Available Nonlinear integrable couplings of super classical-Boussinesq hierarchy based upon an enlarged matrix Lie super algebra were constructed. Then, its super Hamiltonian structures were established by using super trace identity. As its reduction, nonlinear integrable couplings of the classical integrable hierarchy were obtained.

  2. Existence of Multiple Fixed Points for Nonlinear Operators and Applications

    Institute of Scientific and Technical Information of China (English)

    Jing Xian SUN; Ke Mei ZHANG

    2008-01-01

    In this paper,by the fixed point index theory,the number of fixed points for sublinear and asymptotically linear operators via two coupled parallel sub-super solutions is studied.Under suitable conditions,the existence of at least nine or seven distinct fixed points for sublinear and asymptotically linear operators is proved.Finally,the theoretical results are applied to a nonlinear system of Hammerstein integral equations.

  3. Super-resolution

    DEFF Research Database (Denmark)

    Nasrollahi, Kamal; Moeslund, Thomas B.

    2014-01-01

    Super-resolution, the process of obtaining one or more high-resolution images from one or more low-resolution observations, has been a very attractive research topic over the last two decades. It has found practical applications in many real world problems in different fields, from satellite...... the contributions of different authors to the basic concepts of each group. Furthermore, common issues in super-resolution algorithms, such as imaging models and registration algorithms, optimization of the cost functions employed, dealing with color information, improvement factors, assessment of super...

  4. NETL Super Computer

    Data.gov (United States)

    Federal Laboratory Consortium — The NETL Super Computer was designed for performing engineering calculations that apply to fossil energy research. It is one of the world’s larger supercomputers,...

  5. Super-resolution

    DEFF Research Database (Denmark)

    Nasrollahi, Kamal; Moeslund, Thomas B.

    2014-01-01

    and aerial imaging to medical image processing, to facial image analysis, text image analysis, sign and number plates reading, and biometrics recognition, to name a few. This has resulted in many research papers, each developing a new super-resolution algorithm for a specific purpose. The current......Super-resolution, the process of obtaining one or more high-resolution images from one or more low-resolution observations, has been a very attractive research topic over the last two decades. It has found practical applications in many real world problems in different fields, from satellite...... the contributions of different authors to the basic concepts of each group. Furthermore, common issues in super-resolution algorithms, such as imaging models and registration algorithms, optimization of the cost functions employed, dealing with color information, improvement factors, assessment of super...

  6. Super-Kamiokande

    Science.gov (United States)

    Magro, Lluís Martí

    2016-06-01

    The Super-Kamiokande experiment performs a large variety of studies, many of them in the neutrino sector. The archetypes are atmospheric neutrino (recently awarded with the Nobel prize for Mr. T. Kajita) and the solar neutrinos analyses. In these proceedings we report our latest results and present updates to indirect dark matter searches, our solar neutrino analysis and discuss the future upgrade of Super-Kamiokande by loading gadolinium into our ultra-pure water.

  7. The Super Girl Effect

    Institute of Scientific and Technical Information of China (English)

    WANG PEI

    2006-01-01

    @@ In recent years, Changsha,the capital city of Hunan Province, has become famous across China for its innovative TV channel, in particular the cultural phenomenon of the Super Girl talent show. And as far as culture goes, Hunan TV is merely a reflection of a renaissance happening in the city. Animation, music halls, drama festivals and a famous book market are just some of the city's cultural sectors that are benefiting from the fame and notoriety of the Super Girl show.

  8. The formation of super-rings

    CERN Document Server

    Tenorio-Tagle, G

    1980-01-01

    The author has calculated the collision of a small neutral cloud (surface density approximately 10/sup 19/ cm/sup -2/) with a constant density galactic disk. Through the collision, a large amount of energy is deposited in a small volume of the galaxy, resulting in a supersonic expansion of very hot (10/sup 6/-10/sup 7/K) gas into the Galaxy and out of the galactic disk. The expansion generates a large cavity (a super-ring) with physical characteristics (diameter, velocity of expansion, etc.) in agreement with the observations, and a large volume of hot low-density gas with properties similar to those of the observed coronal gas. (31 refs).

  9. Nonlinear Super Integrable Couplings of Super Dirac Hierarchy and Its Super Hamiltonian Structures

    Institute of Scientific and Technical Information of China (English)

    尤福财

    2012-01-01

    We construct nonlinear super integrable couplings of the super integrable Dirac hierarchy based on an enlarged matrix Lie superalgebra. Then its super Hamiltonian structure is furnished by super trace identity. As its reduction, we gain the nonlinear integrable couplings of the classical integrable Dirac hierarchy.

  10. TARGET:?

    National Research Council Canada - National Science Library

    James M Acton

    2014-01-01

      By 2003. as military planners had become worried that the country's long-range conventional weapons, such as cruise missiles, might be too slow to reach hypothetical distant targets that needed to be struck urgently...

  11. Deforming super Riemann surfaces with gravitinos and super Schottky groups

    Energy Technology Data Exchange (ETDEWEB)

    Playle, Sam [Dipartimento di Fisica, Università di Torino and INFN, Sezione di Torino,Via P. Giuria 1, I-10125 Torino (Italy)

    2016-12-12

    The (super) Schottky uniformization of compact (super) Riemann surfaces is briefly reviewed. Deformations of super Riemann surface by gravitinos and Beltrami parameters are recast in terms of super Schottky group cohomology. It is checked that the super Schottky group formula for the period matrix of a non-split surface matches its expression in terms of a gravitino and Beltrami parameter on a split surface. The relationship between (super) Schottky groups and the construction of surfaces by gluing pairs of punctures is discussed in an appendix.

  12. Development and characterization of an antibody-labeled super-paramagnetic iron oxide contrast agent targeting prostate cancer cells for magnetic resonance imaging.

    Directory of Open Access Journals (Sweden)

    David Bates

    Full Text Available In this study we developed, characterized and validated in vitro a functional superparagmagnetic iron-oxide based magnetic resonance contrast agent by conjugating a commercially available iron oxide nanoparticle, Molday ION Rhodamine-B Carboxyl (MIRB, with a deimmunized mouse monoclonal antibody (muJ591 targeting prostate-specific membrane antigen (PSMA. This functional contrast agent is intended for the specific and non-invasive detection of prostate cancer cells that are PSMA positive, a marker implicated in prostate tumor progression and metastasis. The two-step carbodiimide reaction used to conjugate the antibody to the nanoparticle was efficient and we obtained an elemental iron content of 1958 ± 611 per antibody. Immunofluorescence microscopy and flow cytometry showed that the conjugated muJ591:MIRB complex specifically binds to PSMA-positive (LNCaP cells. The muJ591:MIRB complex reduced cell adhesion and cell proliferation on LNCaP cells and caused apoptosis as tested by Annexin V assay, suggesting anti-tumorigenic characteristics. Measurements of the T2 relaxation time of the muJ591:MIRB complex using a 400 MHz Innova NMR and a multi-echo spin-echo sequence on a 3T MRI (Achieva, Philips showed a significant T2 relaxation time reduction for the muJ591:MIRB complex, with a reduced T2 relaxation time as a function of the iron concentration. PSMA-positive cells treated with muJ591:MIRB showed a significantly shorter T2 relaxation time as obtained using a 3T MRI scanner. The reduction in T2 relaxation time for muJ591:MIRB, combined with its specificity against PSMA+LNCaP cells, suggest its potential as a biologically-specific MR contrast agent.

  13. Super-resolution microscopy: a comparative treatment.

    Science.gov (United States)

    Kasuboski, James M; Sigal, Yury J; Joens, Matthew S; Lillemeier, Bjorn F; Fitzpatrick, James A J

    2012-10-01

    One of the fundamental limitations of optical microscopy is that of diffraction, or in essence, how small a beam of light can be focused by using an optical lens system. This constraint, or barrier if you will, was theoretically described by Ernst Abbe in 1873 and is roughly equal to half the wavelength of light used to probe the system. Many structures, particularly those within cells, are much smaller than this limit and thus are difficult to visualize. Over the last two decades, a new field of super-resolution imaging has been created and been developed into a broad range of techniques that allow routine imaging beyond the far-field diffraction limit of light. In this unit we outline the basic principles of the various super-resolution imaging modalities, paying particular attention to the technical considerations for biological imaging. Furthermore, we discuss their various applications in the imaging of both fixed and live biological samples.

  14. Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material

    NARCIS (Netherlands)

    de Leng, Wendy W J; Gadellaa-Van Hooijdonk, Christa G.; Barendregt-Smouter, Françoise A S; Koudijs, Marco J.; Nijman, Ies; Hinrichs, John W.J.; Cuppen, Edwin; van Lieshout, Stef; Loberg, Robert D.; De Jonge, Maja; Voest, Emile E; De Weger, Roel A.; Steeghs, Neeltje; Langenberg, Marlies H G; Sleijfer, Stefan; Willems, Stefan M.; Lolkema, Martijn P.

    2016-01-01

    BACKGROUND: Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have been defined. This study therefore aimed

  15. Using SOLPS to confirm the importance of total flux expansion in Super-X divertors

    Science.gov (United States)

    Moulton, D.; Harrison, J.; Lipschultz, B.; Coster, D.

    2017-06-01

    We show that a central characteristic of Super-X divertors, total flux expansion f R (defined as the ratio of the elementary area normal to the magnetic field at the target to that at the X-point), significantly changes the characteristics of the target plasma for fixed upstream conditions. To isolate the effect of total flux expansion from other effects, we utilise SOLPS-5.0 simulations of an isolated slot divertor leg in a minimally complex, rectangular geometry. The grid is rotated outwards about a fixed X-point in order to perform a scan in which only the total flux expansion increases, by means of a decrease in the target magnetic field at higher major radius. We find that if the SOL remains in the attached, conduction-limited regime throughout the scan, the target electron density scales approximately as {f}{{R}}2, while the target electron temperature scales approximately as 1/{f}{{R}}2, in good agreement with the modified two-point model presented in Petrie et al (2013 Nucl. Fusion 53 113024). If, however, the SOL transitions from the sheath-limited regime to the conduction-limited regime during the scan, the simulated scalings of target electron temperature and density are weaker than predicted by the modified two-point model. The upstream density for transition from sheath- to conduction-limited regimes is found to scale approximately with 1/{f}{{R}}, in agreement with the modified two-point model. Assessing upstream-density-driven detachment onset, we find that the target electron temperature at which target density rollover occurs (∼0.6 eV) is independent of f R. Given this, the modified two-point model predicts a halving of the upstream (and target) densities at which rollover occurs when f R is doubled, in good agreement with the simulation results.

  16. Raspberry Pi super cluster

    CERN Document Server

    Dennis, Andrew K

    2013-01-01

    This book follows a step-by-step, tutorial-based approach which will teach you how to develop your own super cluster using Raspberry Pi computers quickly and efficiently.Raspberry Pi Super Cluster is an introductory guide for those interested in experimenting with parallel computing at home. Aimed at Raspberry Pi enthusiasts, this book is a primer for getting your first cluster up and running.Basic knowledge of C or Java would be helpful but no prior knowledge of parallel computing is necessary.

  17. SuperQuant

    DEFF Research Database (Denmark)

    Gorshkov, Vladimir; Verano-Braga, Thiago; Kjeldsen, Frank

    2015-01-01

    SuperQuant is a quantitative proteomics data processing approach that uses complementary fragment ions to identify multiple co-isolated peptides in tandem mass spectra allowing for their quantification. This approach can be applied to any shotgun proteomics data set acquired with high mass accura...... of the same proteins were close to the values typical for other precursor ion-based quantification methods. The raw data is deposited to ProteomeXchange (PXD001907). The developed node is available for testing at https://github.com/caetera/SuperQuantNode....

  18. Targeted next generation sequencing as a reliable diagnostic assay for the detection of somatic mutations in tumours using minimal DNA amounts from formalin fixed paraffin embedded material

    NARCIS (Netherlands)

    W.W.J. de Leng (Wendy); C.G.M. Gadellaa-Van Hooijdonk (C. G M); F.A.S. Barendregt-Smouter (Françoise A.S.); M.J. Koudijs (Marco J.); I. Nijman (Ies); J.W.J. Hinrichs (John W.J.); E. Cuppen (Edwin); S. van Lieshout (Stef); R.D. Loberg (Robert D.); M.J.A. de Jonge (Maja); E.E. Voest (Emile); R.A. de Weger (Roel); N. Steeghs (Neeltje); M.H. Langenberg (Marlies); S. Sleijfer (Stefan); S.M. Willems (Stefan Martin); M.P. Lolkema (Martijn)

    2016-01-01

    textabstractBackground Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have been defined. This study ther

  19. A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue.

    Science.gov (United States)

    Yuan, Min; Breitkopf, Susanne B; Yang, Xuemei; Asara, John M

    2012-04-12

    The revival of interest in cancer cell metabolism in recent years has prompted the need for quantitative analytical platforms for studying metabolites from in vivo sources. We implemented a quantitative polar metabolomics profiling platform using selected reaction monitoring with a 5500 QTRAP hybrid triple quadrupole mass spectrometer that covers all major metabolic pathways. The platform uses hydrophilic interaction liquid chromatography with positive/negative ion switching to analyze 258 metabolites (289 Q1/Q3 transitions) from a single 15-min liquid chromatography-mass spectrometry acquisition with a 3-ms dwell time and a 1.55-s duty cycle time. Previous platforms use more than one experiment to profile this number of metabolites from different ionization modes. The platform is compatible with polar metabolites from any biological source, including fresh tissues, cancer cells, bodily fluids and formalin-fixed paraffin-embedded tumor tissue. Relative quantification can be achieved without using internal standards, and integrated peak areas based on total ion current can be used for statistical analyses and pathway analyses across biological sample conditions. The procedure takes ∼12 h from metabolite extraction to peak integration for a data set containing 15 total samples (∼6 h for a single sample).

  20. "Super Roman Pots"

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    Remotely controlled re-entrant vacuum vessels, with very thin (0.17 mm) central windows, that will be installed in each downstream arm of intersection I-8. Detectors for a coming physics experiment, placed inside these "Super Roman Pots", can be moved very close to the circulating ISR beams.

  1. A Super Roman Pot

    CERN Multimedia

    1975-01-01

    Remotely controlled re-entrant vacuum vessels, with very thin (0.17 mm) central windows, that were installed in each downstream arm of the ISR intersection I-8. Detectors placed inside these Super Roman Pots could be moved very close to the circulating ISR beams. (See Annual Report 1974 p. 110.)

  2. Measurement of the $b \\bar b$ Production Cross Section in 920 GeV Fixed-Target Proton-Nucleus Collisions

    CERN Document Server

    Abt, I; Adams, M; Albrecht, H; Amaral, V S; Amorim, A; Aplin, S J; Arefev, A; Arino, I; Atiya, M; Aushev, V; Bagaturia, Yu S; Baghshetsyan, R; Balagura, V; Bargiotti, M; Barsuk, S; Barsukova, O; Bassetti, V; Bastos, J; Bauer, C; Bauer, T S; Beck, M; Belkov, A; Belotelov, I; Belyaev, I; Berkhan, K; Bertin, A; Bobchenko, B M; Böcker, M; Bogatyrev, A; Böhm, G; Borgmeier, C; Brauer, M; Broemmelsiek, D R; Bruinsma, M; Bruschi, M; Buchholz, P; Buchler, M; Buran, T; Capéans-Garrido, M; Capponi, M; Carvalho, J; Chamanina, J; Chen, B X; Chistov, R; Chmeissani, M; Christensen, A; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deckers, H; Dehmelt, K; Deppe, H; Dolgoshein, B A; Dong, X; Dreis, H B; Dressel, M; Dujmic, D; Eckmann, R; Egorytchev, V; Ehret, K; Eiges, V; Eisele, F; Emeliyanov, D; Erhan, S; Essenov, S; Fabbri, Franco Luigi; Faccioli, P; Fallot-Burghardt, W; Feuerstack-Raible, M; Flammer, J; Fleckenstein, H; Fominykh, B A; Fourletov, S; Fuljahn, T; Funcke, M; Galli, D; García, A; Garrido, L; Gascón, D; Gellrich, A; Gerndt, K E K; Giacobbe, B; Glass, J; Glebe, T; Goloubkov, D; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Guilitsky, Yu; Hamacher, T; Hansen, J D; Harr, R; Hast, C; Hausmann, S; Hernández, J M; Hildebrandt, M; Hölscher, A; Höpfner, K; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W D; Husemann, U; Igonkina, O; Ispiryan, M; Issever, S; Itterbeck, H; Ivarsson, J; Jagla, T; Jia, Y; Jiang, C; Kaoukher, A; Kapitza, H; Karabekyan, S; Karchin, P; Karpenko, N; Ke, Z; Keller, S; Khasanov, F M; Kim, H; Kiryushin, Yu T; Kisel, I; Klefenz, F; Knöpfle, K T; Kochetkov, V; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kvaratskheliia, T; Lange, A; Lanyov, A V; Lau, K; Leffers, G; Legrand, I; Lewendel, B; Liu Ya Qian; Lohse, T; Loke, R; Lomonosov, B N; Lüdemann, J; Männer, R; Mankel, R; Marconi, U; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Miquel, R; Mizuk, R; Mohapatra, A; Moshkin, A; Moshous, B; Muresan, R; Nam, S; Negodaev, M A; Negri, I; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Oest, T; Oliveira, A; Ouchrif, M; Ould-Saada, F; Padilla, C; Pakhlov, P; Pavlenko, Yu N; Peralta, D; Pernack, R; Perschke, T; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, A; Pose, D; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Ramachandran, S; Ratnikov, F; Reeves, K; Ressing, D; Riechmann, K; Rieling, J; Rietz, M; Riu, I; Robmann, P; Rosen, J; Rothe, C; Rückstuhl, W; Rusinov, V Yu; Rybnikov, V; Ryzhikov, D; Saadi-Ludemann, F; Samtleben, D; Sánchez, F; Sang, M; Saveliev, V; Sbrizzi, A; Schaller, S; Schlein, P E; Schmelling, M; Schmidt, B; Schmidt, S; Schmidt-Parzefall, W; Schreiner, A; Schröder, H; Schultz, H D; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Schwitters, Roy F; Sciacca, F; Semenov, S; Semprini-Cesari, N; Sexauer, E; Seybold, L; Shiu, J; Shuvalov, S; Siccama, I; Skrk, D; Sozuer, L; Soldatov, A; Solunin, S; Somov, A; Somov, S; Souvorov, V; Spahn, M; Spengler, J; Spighi, R; Spiridonov, A A; Spratte, S; Stanovnik, A; Staric, M; Saint-Denis, R; Stegmann, C; Steinbeck, S; Steinkamp, O; Stieler, D; Straumann, U; Sun, F; Sun, H; Symalla, M; Takach, S F; Tesch, N; Thurn, H; Tikhomirov, I; Titov, M; Trunk, U; Truöl, P; Tsakov, I; Uwer, U; Vagnoni, V; Van Eldik, C; Van Staa, R; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wagner, G; Wagner, W; Wahlberg, H; Walenta, Albert H; Walter, M; Walter, T; Wang, J J; Wang, Y M; Wanke, R; Wegener, D; Werthenbach, U; Weyers, P J; Wolters, H; Wurth, R; Wurz, A; Xella, S M; Yang, J; Zaitsev, Yu; Zavertyaev, M V; Zech, G; Zeuner, T; Zhelezov, A; Zheng, Z; Zhu, Z; Zimmermann, R; Zivko, T; Zoccoli, A; Zweizig, J

    2003-01-01

    Using the HERA-B detector, the b-bbar production cross section has been measured in 920 GeV proton collisions on carbon and titanium targets. The b-bbar production was tagged via inclusive bottom quark decays into J/psi, by exploiting the longitudinal separation of J/psi->ll decay vertices from the primary proton-nucleus interaction. Both $e^+e^-$ and $\\mu^+\\mu^-$ channels have been reconstructed and the combined analysis yields the cross section $\\sigma(b \\bar b) = 32 ^{+14}_{-12} (stat) ^{+6}_{-7} (sys) nb/nucleon$.

  3. Measurement of the J/Psi Production Cross Section in 920 GeV/c Fixed-Target Proton-Nucleus Interactions

    CERN Document Server

    Abt, I; Agari, M; Albrecht, H; Aleksandrov, A; Amaral, V S; Amorim, A; Aplin, S J; Aushev, V; Bagaturia, Yu S; Balagura, V; Bargiotti, M; Barsukova, O; Bastos, J; Batista, J; Bauer, C; Bauer, T S; Belkov, A; Belkov, Ar; Belotelov, I; Bertin, A; Bobchenko, B M; Böcker, M; Bogatyrev, A; Böhm, G; Brauer, M; Bruinsma, M; Bruschi, M; Buchholz, P; Buran, T; Carvalho, J; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deppe, H; Dong, X; Dreis, H B; Egorytchev, V; Ehret, K; Eisele, F; Emeliyanov, D; Essenov, S; Fabbri, L; Faccioli, P; Feuerstack-Raible, M; Flammer, J; Fominykh, B A; Funcke, M; Garrido, L; Gellrich, A; Giacobbe, B; Glass, J; Goloubkov, D; Golubkov, Y; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Grimaldi, F; Guilitsky, Yu; Hansen, J D; Hernández, J M; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W D; Husemann, U; Igonkina, O; Ispiryan, M; Jagla, T; Jiang, C; Kapitza, H; Karabekyan, S; Karpenko, N; Keller, S; Kessler, J; Khasanov, F; Kiryushin, Yu T; Kisel, I; Klinkby, E; Knöpfle, K T; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kupper, S; Kvaratskheliia, T; Lanyov, A V; Lau, K; Lewendel, B; Lohse, T; Lomonosov, B N; Männer, R; Mankel, R; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Mizuk, R; Muresan, R; Zur Nedden, M; Negodaev, M; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Ouchrif, M; Ould-Saada, F; Padilla, C; Peralta, D; Pernack, R; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, D; Prystupa, S; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Reeves, K; Ressing, D; Rick, H; Riu, I; Robmann, P; Rostovtseva, I; Rybnikov, V; Sánchez, F; Sbrizzi, A; Schmelling, M; Schmidt, B; Schreiner, A; Schröder, H; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Sciacca, F; Semprini-Cesari, N; Shuvalov, S; Silva, L; Sozuer, L; Solunin, S; Somov, A; Somov, S; Spengler, J; Spighi, R; Spiridonov, A A; Stanovnik, A; Staric, M; Stegmann, C; Subramanian, H S; Symalla, M; Tikhomirov, I; Titov, M; Tsakov, I; Uwer, U; Van Eldik, C; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wahlberg, H; Walenta, Albert H; Walter, M; Wang, J J; Wegener, D; Werthenbach, U; Wolters, H; Wurth, R; Wurz, A; Zaitsev, Yu; Zavertyaev, M V; Zeuner, T; Zhelezov, A; Zheng, Z; Zimmermann, R; Zivko, T; Zoccoli, A

    2006-01-01

    The mid-rapidity (dsigma_(pN)/dy at y=0) and total sigma_(pN) production cross sections of J/Psi mesons are measured in proton-nucleus interactions. Data collected by the HERA-B experiment in interactions of 920 GeV/c protons with carbon, titanium and tungsten targets are used for this analysis. The J/Psi mesons are reconstructed by their decay into lepton pairs. The total production cross section obtained is sigma_(pN)(J/Psi) = 663 +- 74 +- 46 nb/nucleon. In addition, our result is compared with previous measurements.

  4. Measurement of D^0, D^+, D_s^+ and D^{*+} Production in Fixed Target 920 GeV Proton-Nucleus Collisions

    CERN Document Server

    Abt, I; Agari, M; Albrecht, H; Aleksandrov, A; Amaral, V; Amorim, A; Aplin, S J; Aushev, V; Bagaturia, Y; Balagura, V; Bargiotti, M; Barsukova, O; Bastos, J; Batista, J; Bauer, C; Bauer, T S; Belkov, A; Belkov, Ar; Belotelov, I; Bertin, A; Bobchenko, B; Böcker, M; Bogatyrev, A; Böhm, G; Brauer, M; Bruinsma, M; Bruschi, M; Buchholz, P; Buran, T; Carvalho, J; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deppe, H; Dong, X; Dreis, H B; Egorytchev, V; Ehret, K; Eisele, F; Emeliyanov, D; Essenov, S; Fabbri, L; Faccioli, P; Feuerstack-Raible, M; Flammer, J; Fominykh, B; Funcke, M; Garrido, L; Gellrich, A; Giacobbe, B; Glass, J; Goloubkov, D; Golubkov, Y; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Grimaldi, F; Groth-Jensen, J; Guilitsky, Yu; Hansen, J D; Hernández, J M; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W; Husemann, U; Igonkina, O; Ispiryan, M; Jagla, T; Jiang, C; Kapitza, H; Karabekyan, S; Karpenko, N; Keller, S; Kessler, J; Khasanov, F; Kiryushin, Yu T; Kisel, I; Klinkby, E; Knöpfle, K T; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kupper, S; Kvaratskheliia, T; Lanyov, A; Lau, K; Lewendel, B; Lohse, T; Lomonosov, B; Männer, R; Mankel, R; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Mizuk, R; Muresan, R; Zur Nedden, M; Negodaev, M; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Ouchrif, M; Ould-Saada, F; Padilla, C; Peralta, D; Pernack, R; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, D; Prystupa, S; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Reeves, K; Ressing, D; Rick, H; Riu, I; Robmann, P; Rostovtseva, I; Rybnikov, V; Sánchez, F; Sbrizzi, A; Schmelling, M; Schmidt, B; Schreiner, A; Schröder, H; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Sciacca, F; Semprini-Cesari, N; Shuvalov, S; Silva, L; Skrk, D; Sozuer, L; Solunin, S; Somov, A; Somov, S; Spengler, J; Spighi, R; Spiridonov, A; Stanovnik, A; Staric, M; Stegmann, C; Subramania, H S; Symalla, M; Tikhomirov, I; Titov, M; Tsakov, I; Uwer, U; Van Eldik, C; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wahlberg, H; Walenta, A H; Walter, M; Wang, J J; Wegener, D; Werthenbach, U; Wolters, H; Wurth, R; Wurz, A; Xella-Hansen, S; Zaitsev, Yu; Zavertyaev, M; Zeuner, T; Zhelezov, A; Zheng, Z; Zimmermann, R; Zivko, T; Zoccoli, A

    2007-01-01

    The inclusive production cross sections of the charmed mesons D^0, D^+, D_s^+ and D^{*+} have been measured in interactions of 920 GeV protons on C, Ti, and W targets with the HERA-B detector at the HERA storage ring. Differential cross sections as a function of transverse momentum and Feynman's x variable are given for the central rapidity region and for transverse momenta up to $\\pT=3.5$ GeV/$c$. The atomic mass number dependence and the leading to non-leading particle production asymmetries are presented as well.

  5. Research into The Cross Location in Airborne Single-station Fixed Target Direction-finding%机载单站固定目标测向交叉定位研究

    Institute of Scientific and Technical Information of China (English)

    田明辉; 方青; 任清安

    2012-01-01

    机载平台对地面固定目标定位是电子侦察中的一项重要任务。针对机载平台的特点,提出了一种机载单站对地面固定目标的纯方位交叉定位算法,通过测量地面辐射源信号的方位角,结合机载平台的位置与航向信息,建立三维球面弧线计算模型求解目标的地理经纬度,给出了快速计算目标方位斜率的方法,通过多次融合定位提高定位精度。仿真实验中采用卫星工具开发包(STK)仿真软件生成机载平台的位置数据和目标的方位角数据,分析了多次融合定位的收敛情况及不同测向精度下的定位性能,最后给出了一些工程实践性的建议,具有一定的参考意义。%It is an important task in the electronic reconnaissance that the airborne platform locates the ground fixed target.Aiming at the characteristics of airborne platform,this paper puts forward a cross location algorithm that the airborne single-station locates the ground fixed target based on azimuth only,by measuring the azimuth angles of ground radiation source signal,establishes the 3D spherical pitch arc calculation model to find the solution of geographical latitude and longitude of target combining with the position and course information of airborne platform,presents the method to calculate the azimuth slope of target rapidly,improves the locating precision through multi-fusion location,uses satelite took kit(STK) simulation software to generate the position data of airborne platform and azimuth data of target in the simulation experiment,analyzes the convergence of multi-fusion location and the locating performance at different direction finding precision,finally gives some suggestions with engineering practicality,which has definite reference meaning.

  6. The evolution of systolic blood pressure as a strong predictor of cardiovascular risk and the effectiveness of fixed-dose ARB/CCB combinations in lowering levels of this preferential target

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Mourad

    2008-12-01

    Full Text Available Jean-Jacques MouradHypertension Unit, Avicenne Hospital – AP-HP and Paris XIII University Bobigny, FranceAbstract: Elevated blood pressure is an important cardiovascular risk factor. Although targets for both diastolic blood pressure (DBP and systolic blood pressure (SBP are defined by current guidelines, DBP has historically taken precedence in hypertension management. However, there is strong evidence that SBP is superior to DBP as a predictor of cardiovascular events. Moreover, achieving control of SBP is assuming greater importance amongst an aging population. In spite of the growing recognition of the importance of SBP in reducing cardiovascular risk and the emphasis by current guidelines on SBP control, a substantial proportion of patients still fail to achieve SBP targets, and SBP control is achieved much less frequently than DBP control. Thus, new approaches to the management of hypertension are required in order to control SBP and minimize cardiovascular risk. Fixed-dose combination (FDC therapy is an approach that offers the advantages of multiple drug administration and a reduction in regimen complexity that favors compliance. We have reviewed the latest evidence demonstrating the efficacy in targeting SBP of the most recent FDC products; combinations of the calcium channel blocker (CCB, amlodipine, with angiotensin receptor blockers (ARBs, valsartan or olmesartan. In addition, results from studies with new classes of agent are outlined.Keywords: hypertension, systolic blood pressure, angiotensin receptor blocker, calcium channel blocker, combination therapy

  7. Super-resolution optical telescopes with local light diffraction shrinkage

    Science.gov (United States)

    Wang, Changtao; Tang, Dongliang; Wang, Yanqin; Zhao, Zeyu; Wang, Jiong; Pu, Mingbo; Zhang, Yudong; Yan, Wei; Gao, Ping; Luo, Xiangang

    2015-12-01

    Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinkage associated with optical super-oscillatory phenomenon is proposed for real-time and optically restoring super-resolution imaging information in a telescope system. It is found that fine target features concealed in diffraction-limited optical images of a telescope could be observed in a small local field of view, benefiting from a relayed metasurface-based super-oscillatory imaging optics in which some local Fourier components beyond the cut-off frequency of telescope could be restored. As experimental examples, a minimal resolution to 0.55 of Rayleigh criterion is obtained, and imaging complex targets and large targets by superimposing multiple local fields of views are demonstrated as well. This investigation provides an access for real-time, incoherent and super-resolution telescopes without the manipulation of distant targets. More importantly, it gives counterintuitive evidence to the common knowledge that relayed optics could not deliver more imaging details than objective systems.

  8. Heavy-Ion Physics at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC): Feasibility Studies for Quarkonium and Drell-Yan Production

    Science.gov (United States)

    Trzeciak, B.; Da Silva, C.; Ferreiro, E. G.; Hadjidakis, C.; Kikola, D.; Lansberg, J. P.; Massacrier, L.; Seixas, J.; Uras, A.; Yang, Z.

    2017-09-01

    We outline the case for heavy-ion-physics studies using the multi-TeV lead LHC beams in the fixed-target mode. After a brief contextual reminder, we detail the possible contributions of AFTER@LHC to heavy-ion physics with a specific emphasis on quarkonia. We then present performance simulations for a selection of observables. These show that Υ (nS), J/ψ and ψ (2S) production in heavy-ion collisions can be studied in new energy and rapidity domains with the LHCb and ALICE detectors. We also discuss the relevance to analyse the Drell-Yan pair production in asymmetric nucleus-nucleus collisions to study the factorisation of the nuclear modification of partonic densities and of further quarkonium states to restore their status of golden probes of the quark-gluon plasma formation.

  9. Design on Digital Disruptive Pattern for Fixed Targets%固定目标伪装的数码迷彩设计

    Institute of Scientific and Technical Information of China (English)

    喻钧; 王璨; 胡志毅

    2011-01-01

    The traditional camouflage is based on a number of irregular spots or stripes, whose edges are smooth as well as they have clear boundaries between different colors. The visual distinction degree is so strong that the camouflage effect is debased. The digital disruptive pattern can break the boundary of a camouflaged target between different colors, as well as makes it blurred and broken, so as to attain a better camouflaged effect. This paper presents an algorithm which can generate digital disruptive pattern according to background images of the target. It uses a square template to traverse the background image as to rearrange the dominant colors of it, followed that determines the size of a mosaic block, Finally the digital disruptive pattern is generated. The experimental result shows that, the generated pattern is easier to blend with the natural background than the traditional camouflage, and achieves a good effect of the optical camouflage.%传统迷彩的边缘平滑、色彩分明、视觉区分度强,其设计过程往往脱离伪装目标的实际背景,不能很好地与背景相融合.数码迷彩在图案上呈现不规则的重叠,不同颜色间的边缘模糊、破碎,极易模拟自然背景.文章提出一种根据目标的背景生成数码迷彩的新方法.根据实际需求确定数码单元的尺寸,然后采用模板遍历的方法对背景图像中的主要颜色进行重新排布,最后生成数码迷彩.利用此算法生成的数码迷彩能够较好地保留背景的细节特征,并与目标的自然背景高度融合,从而达到良好的变形和光学伪装效果.

  10. SuperSegger

    DEFF Research Database (Denmark)

    Stylianidou, Stella; Brennan, Connor; Nissen, Silas B

    2016-01-01

    -colonies with many cells, facilitating the analysis of cell-cycle dynamics in bacteria as well as cell-contact mediated phenomena. This package has a range of built-in capabilities for characterizing bacterial cells, including the identification of cell division events, mother, daughter, and neighboring cells......Many quantitative cell biology questions require fast yet reliable automated image segmentation to identify and link cells from frame-to-frame, and characterize the cell morphology and fluorescence. We present SuperSegger, an automated MATLAB-based image processing package well......-suited to quantitative analysis of high-throughput live-cell fluorescence microscopy of bacterial cells. SuperSegger incorporates machine-learning algorithms to optimize cellular boundaries and automated error resolution to reliably link cells from frame-to-frame. Unlike existing packages, it can reliably segment micro...

  11. Search For Muon Neutrino(anti-muon Neutrino) Decaying To Electron Neutrino(anti-electron Neutrino) Oscillations In The F815(nutev) Fixed Target Neutrino Experiment At Fermilab

    CERN Document Server

    Avvakumov, S

    2002-01-01

    Limits on νμ → νe and νμ → ν e oscillations (separately) are extracted using the NuTeV detector with sign selected νμ and ν μ beams. A statistical analysis of the longitudinal shower energy deposition in the neutrino target-calorimeter is used to identify the fraction of νeN charged-current interactions in a sample ν μN → νμX candidate events. Neutrino energies range from 30 to 350 GeV and νμ flight lengths vary from 0.9 to 1.4 km. In νμ mode, the NuTeV data exclude the high Δ m2 νμ → νe oscillation region favored by the LSND experiment. In addition, if we assume no CP violation in the neutrino sector, the NuTeV results exclude νμ(ν μ) → νe(ν e) oscillations with sin2 2α > 0.9 × 10−3 for large Δm2 ≫ 1000 eV2. Fo...

  12. NASA Super Pressure Balloon

    Science.gov (United States)

    Fairbrother, Debbie

    2017-01-01

    NASA is in the process of qualifying the mid-size Super Pressure Balloon (SPB) to provide constant density altitude flight for science investigations at polar and mid-latitudes. The status of the development of the 18.8 million cubic foot SPB capable of carrying one-tone of science to 110,000 feet, will be given. In addition, the operating considerations such as launch sites, flight safety considerations, and recovery will be discussed.

  13. Super-diversité

    NARCIS (Netherlands)

    Crul, M.R.J.; Schneider, J.; Lelie, F.

    2013-01-01

    Le concept de super-diversité, en cernant les conditions d'un scénario 'avenir optimiste, offre un nouvel éclairage au débat sur l'intégration. Nous sommes à la croisée des chemins. Cette étude comparative internationale montre qu'un avenir souriant se profile dans les villes qui donnent des chances

  14. Performing the Super Instrument

    DEFF Research Database (Denmark)

    Kallionpaa, Maria

    2016-01-01

    The genre of contemporary classical music has seen significant innovation and research related to new super, hyper, and hybrid instruments, which opens up a vast palette of expressive potential. An increasing number of composers, performers, instrument designers, engineers, and computer programmers...... provides the performer extensive virtuoso capabilities in terms of instrumental range, harmony, timbre, or spatial, textural, acoustic, technical, or technological qualities. The discussion will be illustrated by a composition case study involving augmented musical instrument electromagnetic resonator...

  15. Performing the Super Instrument

    DEFF Research Database (Denmark)

    Kallionpaa, Maria

    2016-01-01

    provides the performer extensive virtuoso capabilities in terms of instrumental range, harmony, timbre, or spatial, textural, acoustic, technical, or technological qualities. The discussion will be illustrated by a composition case study involving augmented musical instrument electromagnetic resonator......The genre of contemporary classical music has seen significant innovation and research related to new super, hyper, and hybrid instruments, which opens up a vast palette of expressive potential. An increasing number of composers, performers, instrument designers, engineers, and computer programmers...

  16. Characterising Super-Earths

    Directory of Open Access Journals (Sweden)

    Valencia D.

    2011-02-01

    Full Text Available The era of Super-Earths has formally begun with the detection of transiting low-mass exoplanets CoRoT-7b and GJ 1214b. In the path of characterising super-Earths, the first step is to infer their composition. While the discovery data for CoRoT-7b, in combination with the high atmospheric mass loss rate inferred from the high insolation, suggested that it was a rocky planet, the new proposed mass values have widened the possibilities. The combined mass range 1−10 M⊕ allows for a volatile-rich (and requires it if the mass is less than 4 M⊕ , an Earth-like or a super-Mercury-like composition. In contrast, the radius of GJ 1214b is too large to admit a solid composition, thus it necessarily to have a substantial gas layer. Some evidence suggests that within this gas layer H/He is a small but non-negligible component. These two planets are the first of many transiting low-mass exoplanets expected to be detected and they exemplify the limitations faced when inferring composition, which come from the degenerate character of the problem and the large error bars in the data.

  17. Super Fuzzy Matrices and Super Fuzzy Models for Social Scientists

    CERN Document Server

    Kandasamy, W B Vasantha; Amal, K

    2008-01-01

    This book introduces the concept of fuzzy super matrices and operations on them. This book will be highly useful to social scientists who wish to work with multi-expert models. Super fuzzy models using Fuzzy Cognitive Maps, Fuzzy Relational Maps, Bidirectional Associative Memories and Fuzzy Associative Memories are defined here. The authors introduce 13 multi-expert models using the notion of fuzzy supermatrices. These models are described with illustrative examples. This book has three chapters. In the first chaper, the basic concepts about super matrices and fuzzy super matrices are recalled. Chapter two introduces the notion of fuzzy super matrices adn their properties. The final chapter introduces many super fuzzy multi expert models.

  18. Super-quantum curves from super-eigenvalue models

    CERN Document Server

    Ciosmak, Paweł; Manabe, Masahide; Sułkowski, Piotr

    2016-01-01

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce $\\beta$-deformed version of those models, and derive differential equations for associated $\\alpha/\\beta$-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  19. Super-quantum curves from super-eigenvalue models

    Science.gov (United States)

    Ciosmak, Paweł; Hadasz, Leszek; Manabe, Masahide; Sułkowski, Piotr

    2016-10-01

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce β-deformed version of those models, and derive differential equations for associated α/ β-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  20. Super-quantum curves from super-eigenvalue models

    Energy Technology Data Exchange (ETDEWEB)

    Ciosmak, Paweł [Faculty of Mathematics, Informatics and Mechanics, University of Warsaw,ul. Banacha 2, 02-097 Warsaw (Poland); Hadasz, Leszek [M. Smoluchowski Institute of Physics, Jagiellonian University,ul. Łojasiewicza 11, 30-348 Kraków (Poland); Manabe, Masahide [Faculty of Physics, University of Warsaw,ul. Pasteura 5, 02-093 Warsaw (Poland); Sułkowski, Piotr [Faculty of Physics, University of Warsaw,ul. Pasteura 5, 02-093 Warsaw (Poland); Walter Burke Institute for Theoretical Physics, California Institute of Technology,1200 E. California Blvd, Pasadena, CA 91125 (United States)

    2016-10-10

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce β-deformed version of those models, and derive differential equations for associated α/β-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  1. Pulsating stars in SuperWASP

    Directory of Open Access Journals (Sweden)

    Holdsworth Daniel L.

    2017-01-01

    Full Text Available SuperWASP is one of the largest ground-based surveys for transiting exoplanets. To date, it has observed over 31 million stars. Such an extensive database of time resolved photometry holds the potential for extensive searches of stellar variability, and provide solid candidates for the upcoming TESS mission. Previous work by e.g. [15], [5], [12] has shown that the WASP archive provides a wealth of pulsationally variable stars. In this talk I will provide an overview of the SuperWASP project, present some of the published results from the survey, and some of the on-going work to identify key targets for the TESS mission.

  2. ON THE NUMBER OF FIXED POINTS OF NONLINEAR OPERATORS AND APPLICATIONS

    Institute of Scientific and Technical Information of China (English)

    SUN Jingxian; ZHANG Kemei

    2003-01-01

    In this paper, the famous Amann three-solution theorem is generalized. Multiplicity question of fixed points for nonlinear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, the existence of at least six distinct fixed points of nonlinear operators is proved. The theoretical results are then applied to nonlinear system of Hammerstein integral equations.

  3. Super insulating aerogel glazing

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe; Jensen, Karsten Ingerslev; Kristiansen, Finn Harken

    2004-01-01

    Monolithic silica aerogel offers the possibility of combining super insulation and high solar energy transmittance, which has been the background for a previous and a current EU project on research and development of monolithic silica aerogel as transparent insulation in windows. Generally, windows...... form the weakest part of the thermal envelope with respect to heat loss coefficient, but on the other hand also play an important role for passive solar energy utilisation. For window orientations other than south, the net energy balance will be close to or below zero. However, the properties...

  4. Super insulating aerogel glazing

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe; Jensen, Karsten Ingerslev; Kristiansen, Finn Harken

    2005-01-01

    This paper describes the application results of a previous and current EU-project on super insulating glazing based on monolithic silica aerogel. Prototypes measuring approx. 55´55 cm2 have been made with 15 mm evacuated aerogel between two layers of low-iron glass. Anti-reflective treatment...... of the glass and a heat-treatment of the aerogel increases the visible quality and the solar energy transmittance. A low-conductive rim seal solution with the required vacuum barrier properties has been developed along with a reliable assembly and evacuation process. The prototypes have a centre heat loss...

  5. Super-heptazethrene

    KAUST Repository

    Zeng, Wangdong

    2016-05-30

    The challenging synthesis of a laterally extended heptazethrene molecule, the super-heptazethrene derivative SHZ-CF3, is reported. This molecule was prepared using a strategy involving a multiple selective intramolecular Friedel–Crafts alkylation followed by oxidative dehydrogenation. Compound SHZ-CF3 exhibits an open-shell singlet diradical ground state with a much larger diradical character compared with the heptazethrene derivatives. An intermediate dibenzo-terrylene SHZ-2H was also obtained during the synthesis. This study provides a new synthetic method to access large-size quinoidal polycyclic hydrocarbons with unique physical properties.

  6. Super-Exponential Solution for a Retrial Supermarket Model

    CERN Document Server

    Li, Quan-Lin; Wang, Yang

    2011-01-01

    In this paper, we provide a new and effective approach for studying super-exponential solution of a retrial supermarket model with Poisson arrivals, exponential service times and exponential retrial times and with two different probing-server numbers. We describe the retrial supermarket model as a system of differential equations by means of density-dependent jump Markov processes, and obtain an iterative algorithm for computing the fixed point of the system of differential equations. Based on the fixed point, we analyze the expected sojourn time that a tagged arriving customer spends in this system, and use numerical examples to indicate different influence of the two probing-server numbers on system performance including the fixed point and the expected sojourn time. Furthermore, we analyze exponential convergence of the current location of the retrial supermarket model to the fixed point, and apply the Kurtz Theorem to study density-dependent jump Markov process given in the retrial supermarket model, whic...

  7. The computation of fixed points and applications

    CERN Document Server

    Todd, Michael J

    1976-01-01

    Fixed-point algorithms have diverse applications in economics, optimization, game theory and the numerical solution of boundary-value problems. Since Scarf's pioneering work [56,57] on obtaining approximate fixed points of continuous mappings, a great deal of research has been done in extending the applicability and improving the efficiency of fixed-point methods. Much of this work is available only in research papers, although Scarf's book [58] gives a remarkably clear exposition of the power of fixed-point methods. However, the algorithms described by Scarf have been super~eded by the more sophisticated restart and homotopy techniques of Merrill [~8,~9] and Eaves and Saigal [1~,16]. To understand the more efficient algorithms one must become familiar with the notions of triangulation and simplicial approxi- tion, whereas Scarf stresses the concept of primitive set. These notes are intended to introduce to a wider audience the most recent fixed-point methods and their applications. Our approach is therefore ...

  8. Quantitative super-resolution microscopy

    NARCIS (Netherlands)

    Harkes, Rolf

    2016-01-01

    Super-Resolution Microscopy is an optical fluorescence technique. In this thesis we focus on single molecule super-resolution, where the position of single molecules is determined. Typically these molecules can be localized with a 10 to 30nm precision. This technique is applied in four different s

  9. Super Marx Generator for Thermonuclear Ignition

    CERN Document Server

    Winterberg, Friedwardt

    2008-01-01

    In ongoing electric pulse power driven inertial confinement fusion experiments, Marx generators are connected in parallel with the target in the center of a ring of the Marx generators. There the currents, not the voltages add up. Instead of connecting a bank of Marx generator in parallel, one may connect them in series, adding up their voltages, not the currents. If, for example, fifty 20 MV Marx generators are connected in series, they would add up to a gigavolt. But to prevent breakdown, the adding up of the voltages in such a super-Marx generator must be fast. For this reason, it is proposed that each of the Marx generators charges up a fast discharge capacitor, with the thusly charged fast capacitors becoming the elements of a second stage super Marx generator. In a super Marx generator, the Marx generators also assume the role of the resistors in the original Marx circuit. With a voltage of 10^9 Volt and a discharge current of 10^7 Ampere, the generation of a 10^16 Watt GeV proton beam becomes possible,...

  10. Super insulating aerogel glazing

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe; Jensen, Karsten Ingerslev; Kristiansen, Finn Harken

    2004-01-01

    Monolithic silica aerogel offers the possibility of combining super insulation and high solar energy transmittance, which has been the background for a previous and a current EU project on research and development of monolithic silica aerogel as transparent insulation in windows. Generally, windows...... form the weakest part of the thermal envelope with respect to heat loss coefficient, but on the other hand also play an important role for passive solar energy utilisation. For window orientations other than south, the net energy balance will be close to or below zero. However, the properties...... of aerogel glazing will allow for a positive net energy gain even for north facing vertical windows in a Danish climate during the heating season. This means that high quality daylight can be obtained even with additional energy gain. On behalf of the partners of the two EU projects, results related...

  11. Super-multiplex vibrational imaging

    Science.gov (United States)

    Wei, Lu; Chen, Zhixing; Shi, Lixue; Long, Rong; Anzalone, Andrew V.; Zhang, Luyuan; Hu, Fanghao; Yuste, Rafael; Cornish, Virginia W.; Min, Wei

    2017-04-01

    The ability to visualize directly a large number of distinct molecular species inside cells is increasingly essential for understanding complex systems and processes. Even though existing methods have successfully been used to explore structure-function relationships in nervous systems, to profile RNA in situ, to reveal the heterogeneity of tumour microenvironments and to study dynamic macromolecular assembly, it remains challenging to image many species with high selectivity and sensitivity under biological conditions. For instance, fluorescence microscopy faces a ‘colour barrier’, owing to the intrinsically broad (about 1,500 inverse centimetres) and featureless nature of fluorescence spectra that limits the number of resolvable colours to two to five (or seven to nine if using complicated instrumentation and analysis). Spontaneous Raman microscopy probes vibrational transitions with much narrower resonances (peak width of about 10 inverse centimetres) and so does not suffer from this problem, but weak signals make many bio-imaging applications impossible. Although surface-enhanced Raman scattering offers high sensitivity and multiplicity, it cannot be readily used to image specific molecular targets quantitatively inside live cells. Here we use stimulated Raman scattering under electronic pre-resonance conditions to image target molecules inside living cells with very high vibrational selectivity and sensitivity (down to 250 nanomolar with a time constant of 1 millisecond). We create a palette of triple-bond-conjugated near-infrared dyes that each displays a single peak in the cell-silent Raman spectral window; when combined with available fluorescent probes, this palette provides 24 resolvable colours, with the potential for further expansion. Proof-of-principle experiments on neuronal co-cultures and brain tissues reveal cell-type-dependent heterogeneities in DNA and protein metabolism under physiological and pathological conditions, underscoring the

  12. Xinjiang Girl World Super Model

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Leading Chinese model Yue Mei won thetitle of World Super Model at the ’98 WorldSuper Model Competition held in FranceSeptember 6 - 17. Yue, a university studentfrom the Xinjiang Uygur AutonomousRegion, had won the top title at ’98 ChinaSuper Model Competition held in Beijingone month earier.After that, she underwentone month’s professional modeling trainingwith the New Silk Road ModelingManagement Company before setting off forthe world competition. In France, Yueimpressed the judges with her strikingfeatures, and display of oriental elegance and

  13. QCD at Fixed Topology

    CERN Document Server

    Brower, Richard C; Negele, John W; Wiese, U J

    2003-01-01

    Since present Monte Carlo algorithms for lattice QCD may become trapped in a fixed topological charge sector, it is important to understand the effect of calculating at fixed topology. In this work, we show that although the restriction to a fixed topological sector becomes irrelevant in the infinite volume limit, it gives rise to characteristic finite size effects due to contributions from all $\\theta$-vacua. We calculate these effects and show how to extract physical results from numerical data obtained at fixed topology.

  14. Low-energy neutrino observation at Super-Kamiokande-III

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Y [Kamioka Observatory, ICRR, University of Tokyo, 456 Higashi-Mozumi, Kamioka-cho, Hida-shi, Gifu 506-1205 (Japan)], E-mail: takeuchi@icrr.u-tokyo.ac.jp

    2008-07-15

    Super-Kamiokande-III (SK-III) has been started its observation in July 2006. The main targets of low-energy neutrinos are the solar neutrinos and the diffuse supernova neutrino background. In this paper, the current status of the solar neutrino observation in SK-III is reported.

  15. SuperB Progress Reports Accelerator

    CERN Document Server

    Biagini, Maria Enrica; Boscolo, M; Buonomo, B; Demma, T; Drago, A; Esposito, M; Guiducci, S; Mazzitelli, G; Pellegrino, L; Preger, M A; Raimondi, P; Ricci, R; Rotundo, U; Sanelli, C; Serio, M; Stella, A; Tomassini, S; Zobov, M; Bertsche, K; Brachman, A; Cai, Y; Chao, A; Chesnut, R; Donald, M.H; Field, C; Fisher, A; Kharakh, D; Krasnykh, A; Moffeit, K; Nosochkov, Y; Pivi, M; Seeman, J; Sullivan, M.K; Weathersby, S; Weidemann, A; Weisend, J; Wienands, U; Wittmer, W; Woods, M; Yocky, G; Bogomiagkov, A; Koop, I; Levichev, E; Nikitin, S; Okunev, I; Piminov, P; Sinyatkin, S; Shatilov, D; Vobly, P; Bosi, F; Liuzzo, S; Paoloni, E; Bonis, J; Chehab, R; Le Meur, G; Lepercq, P; Letellier-Cohen, F; Mercier, B; Poirier, F; Prevost, C; Rimbault, C; Touze, F; Variola, A; Bolzon, B; Brunetti, L; Jeremie, A; Baylac, M; Bourrion, O; De Conto, J M; Gomez, Y; Meot, F; Monseu, N; Tourres, D; Vescovi, C; Chanci, A; Napoly, O; Barber, D P; Bettoni, S; Quatraro, D

    2010-01-01

    This report details the present status of the Accelerator design for the SuperB Project. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

  16. SuperB Progress Report: Detector

    Energy Technology Data Exchange (ETDEWEB)

    Grauges, E.; /Barcelona U., ECM; Donvito, G.; Spinoso, V.; /INFN, Bari /Bari U.; Manghisoni, M.; Re, V.; Traversi, G.; /INFN, Pavia /Bergamo U., Ingengneria Dept.; Eigen, G.; Fehlker, D.; Helleve, L.; /Bergen U.; Carbone, A.; Di Sipio, R.; Gabrielli, A.; Galli, D.; Giorgi, F.; Marconi, U.; Perazzini, S.; Sbarra, C.; Vagnoni, V.; Valentinetti, S.; Villa, M.; Zoccoli, A.; /INFN, Bologna /Bologna U. /Caltech /Carleton U. /Cincinnati U. /INFN, CNAF /INFN, Ferrara /Ferrara U. /UC, Irvine /Taras Shevchenko U. /Orsay, LAL /LBL, Berkeley /UC, Berkeley /Frascati /INFN, Legnaro /Orsay, IPN /Maryland U. /McGill U. /INFN, Milan /Milan U. /INFN, Naples /Naples U. /Novosibirsk, IYF /INFN, Padua /Padua U. /INFN, Pavia /Pavia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Caltech /INFN, Pisa /Pisa U. /Pisa, Scuola Normale Superiore /PNL, Richland /Queen Mary, U. of London /Rutherford /INFN, Rome /Rome U. /INFN, Rome2 /Rome U.,Tor Vergata /INFN, Rome3 /Rome III U. /SLAC /Tel Aviv U. /INFN, Turin /Turin U. /INFN, Padua /Trento U. /INFN, Trieste /Trieste U. /TRIUMF /British Columbia U. /Montreal U. /Victoria U.

    2012-02-14

    This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

  17. What's So Super about Superfoods?

    Science.gov (United States)

    ... with meals. The Skinny on Common Super Foods Salmon is a fatty fish that’s low in saturated ... soy nuts are high in polyunsaturated fat, fiber, vitamins and minerals but low in saturated fat. They ...

  18. Super Ministries,Better Administration

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Chinese lawmakers on March 15th endorsed a State Counci l proposal for institutional overhaul of the tentral government,which involves the establishment of"super ministries"concerning energy,transport,industry and environmental protection.

  19. Results from Super-Kamiokande and K2K

    Indian Academy of Sciences (India)

    M R Vagins

    2003-02-01

    Results from Super-Kamiokande-I’s entire 1496 live days of solar neutrino data are presented, including the absolute flux, energy spectrum, zenith angle (day/night) and seasonal variation. The possibility of MSW and vacuum oscillations is discussed in light of these results. Results from the first 1289 days of Super-K-I’s atmospheric neutrino analysis are also presented, including the evidence for → oscillations, against → sterile oscillations, and the current limits on proton decay. Finally, results based on 5.6 × 1019 protons on target are given for the K2K long-baseline neutrino oscillation experiment.

  20. What are super-enhancers?

    Science.gov (United States)

    Pott, Sebastian; Lieb, Jason D

    2015-01-01

    The term 'super-enhancer' has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin immunoprecipitation and sequencing (ChIP-seq). Here we review the identification and composition of super-enhancers, describe links between super-enhancers, gene regulation and disease, and discuss the functional significance of enhancer clustering. We also provide our perspective regarding the proposition that super-enhancers are a regulatory entity conceptually distinct from what was known before the introduction of the term. Our opinion is that there is not yet strong evidence that super-enhancers are a novel paradigm in gene regulation and that use of the term in this context is not currently justified. However, the term likely identifies strong enhancers that exhibit behaviors consistent with previous models and concepts of transcriptional regulation. In this respect, the super-enhancer definition is useful in identifying regulatory elements likely to control genes important for cell type specification.

  1. Holography based super resolution

    Science.gov (United States)

    Hussain, Anwar; Mudassar, Asloob A.

    2012-05-01

    This paper describes the simulation of a simple technique of superresolution based on holographic imaging in spectral domain. The input beam assembly containing 25 optical fibers with different orientations and positions is placed to illuminate the object in the 4f optical system. The position and orientation of each fiber is calculated with respect to the central fiber in the array. The positions and orientations of the fibers are related to the shift of object spectrum at aperture plane. During the imaging process each fiber is operated once in the whole procedure to illuminate the input object transparency which gives shift to the object spectrum in the spectral domain. This shift of the spectrum is equal to the integral multiple of the pass band aperture width. During the operation of single fiber (ON-state) all other fibers are in OFF-state at that time. The hologram recorded by each fiber at the CCD plane is stored in computer memory. At the end of illumination process total 25 holograms are recorded by the whole fiber array and by applying some post processing and specific algorithm single super resolved image is obtained. The superresolved image is five times better than the band-limited image. The work is demonstrated using computer simulation only.

  2. The SPL-based Neutrino Super Beam

    CERN Document Server

    Baussan, E; Bobeth, C; Bouquerel, E; Caretta, O; Cupial, P; Davenne, T; Densham, C; Dracos, M; Fitton, M; Gaudiot, G; Kozien, M; Lacny, L; Lepers, B; Longhin, A; Loveridge, P; Osswald, F; Poussot, P; Rooney, M; Skoczen, B; Szybinski, B; Ustrzycka, A; Vassilopoulos, N; Wilcox, D; Wroblewski, A; Wurtz, J; Zeter, V; Zito, M

    2012-01-01

    The EUROnu Super Beam work package has studied a neutrino beam based on SPL at CERN and aimed at MEMPHYS, a large water Cherenkov detector, proposed for the Laboratoire Souterrain de Modane (Fr\\'ejus tunnel, France), with a baseline of 130 km. The aim of this proposed experiment is to study the CP violation in the neutrino sector. In the study reported here, we have developed the conceptual design of the neutrino beam, especially the target and the magnetic focusing device. Indeed, this beam present several unprecedented challenges, like the high primary proton beam power (4 MW), the high repetition rate (50 Hz) and the low energy of the protons (4.5 GeV). The design is completed by a study of all the main component of the system, starting from the transport system to guide the beam to the target up to the beam dump.

  3. Twisted Superspace for N=D=2 Super BF and Yang-Mills with Dirac-K\\"ahler Fermion Mechanism

    CERN Document Server

    Kato, J; Uchida, Y; Kato, Junji; Kawamoto, Noboru; Uchida, Yukiya

    2003-01-01

    We propose a twisted D=N=2 superspace formalism. The relation between the twisted super charges including the BRST charge, vector and pseudo scalar super charges and the N=2 spinor super charges is established. We claim that this relation is essentially related with the Dirac-K\\"ahler fermion mechanism. We show that a fermionic bilinear form of twisted N=2 chiral and anti-chiral superfields is equivalent to the quantized version of BF theory with the Landau type gauge fixing while a bosonic bilinear form leads to the N=2 Wess-Zumino action. We then construct a Yang-Mills action described by the twisted N=2 chiral and vector superfields, and show that the action is equivalent to the twisted version of the D=N=2 super Yang-Mills action, previously obtained from the quantized generalized topological Yang-Mills action with instanton gauge fixing.

  4. Fixed-point adiabatic quantum search

    Science.gov (United States)

    Dalzell, Alexander M.; Yoder, Theodore J.; Chuang, Isaac L.

    2017-01-01

    Fixed-point quantum search algorithms succeed at finding one of M target items among N total items even when the run time of the algorithm is longer than necessary. While the famous Grover's algorithm can search quadratically faster than a classical computer, it lacks the fixed-point property—the fraction of target items must be known precisely to know when to terminate the algorithm. Recently, Yoder, Low, and Chuang [Phys. Rev. Lett. 113, 210501 (2014), 10.1103/PhysRevLett.113.210501] gave an optimal gate-model search algorithm with the fixed-point property. Previously, it had been discovered by Roland and Cerf [Phys. Rev. A 65, 042308 (2002), 10.1103/PhysRevA.65.042308] that an adiabatic quantum algorithm, operating by continuously varying a Hamiltonian, can reproduce the quadratic speedup of gate-model Grover search. We ask, can an adiabatic algorithm also reproduce the fixed-point property? We show that the answer depends on what interpolation schedule is used, so as in the gate model, there are both fixed-point and non-fixed-point versions of adiabatic search, only some of which attain the quadratic quantum speedup. Guided by geometric intuition on the Bloch sphere, we rigorously justify our claims with an explicit upper bound on the error in the adiabatic approximation. We also show that the fixed-point adiabatic search algorithm can be simulated in the gate model with neither loss of the quadratic Grover speedup nor of the fixed-point property. Finally, we discuss natural uses of fixed-point algorithms such as preparation of a relatively prime state and oblivious amplitude amplification.

  5. Electrically tuned super-capacitors

    CERN Document Server

    Chowdhury, Tazima S

    2015-01-01

    Fast charging and discharging of large amounts of electrical energy make super-capacitors ideal for short-term energy storage [1-5]. In its simplest form, the super-capacitor is an electrolytic capacitor made of an anode and a cathode immersed in an electrolyte. As for an ordinary capacitor, minimizing the charge separation distance and increasing the electrode area increase capacitance. In super-capacitors, charge separation is of nano-meter scale at each of the electrode interface (the Helmholtz double layer). Making the electrodes porous increases their effective surface area [6-8]. A separating layer between the anode and the cathode electrodes is used to minimize unintentional electrical discharge (Figure 1). Here we show how to increase the capacitance of super-capacitors by more than 45 percent when modifying the otherwise passive separator layer into an active diode-like structure. Active control of super-capacitors may increase their efficiency during charge and discharge cycles. Controlling ion flow...

  6. Quantization of super Teichmueller spaces

    Energy Technology Data Exchange (ETDEWEB)

    Aghaei, Nezhla

    2016-08-15

    The quantization of the Teichmueller spaces of Riemann surfaces has found important applications to conformal field theory and N=2 supersymmetric gauge theories. We construct a quantization of the Teichmueller spaces of super Riemann surfaces, using coordinates associated to the ideal triangulations of super Riemann surfaces. A new feature is the non-trivial dependence on the choice of a spin structure which can be encoded combinatorially in a certain refinement of the ideal triangulation. We construct a projective unitary representation of the groupoid of changes of refined ideal triangulations. Therefore, we demonstrate that the dependence of the resulting quantum theory on the choice of a triangulation is inessential. In the quantum Teichmueller theory, it was observed that the key object defining the Teichmueller theory has a close relation to the representation theory of the Borel half of U{sub q}(sl(2)). In our research we observed that the role of U{sub q}(sl(2)) is taken by quantum superalgebra U{sub q}(osp(1 vertical stroke 2)). A Borel half of U{sub q}(osp(1 vertical stroke 2)) is the super quantum plane. The canonical element of the Heisenberg double of the quantum super plane is evaluated in certain infinite dimensional representations on L{sup 2}(R) x C{sup 1} {sup vertical} {sup stroke} {sup 1} and compared to the flip operator from the Teichmueller theory of super Riemann surfaces.

  7. Fixed mobile convergence handbook

    CERN Document Server

    Ahson, Syed A

    2010-01-01

    From basic concepts to future directions, this handbook provides technical information on all aspects of fixed-mobile convergence (FMC). The book examines such topics as integrated management architecture, business trends and strategic implications for service providers, personal area networks, mobile controlled handover methods, SIP-based session mobility, and supervisory and notification aggregator service. Case studies are used to illustrate technical and systematic implementation of unified and rationalized internet access by fixed-mobile network convergence. The text examines the technolo

  8. Optically fixed photorefractive correlator

    Institute of Scientific and Technical Information of China (English)

    刘友文; 刘立人; 周常河; 徐良瑛

    2002-01-01

    An optically fixed photorefractive correlator is presented, where two-centre non-volatile holographic recording isemployed to write and fix the matched filter in doubly doped LiNbO3 crystals. This correlator shows good correlationcharacteristics and insensitivity to the writing beam during readout. It can be used in cases requiring stability and notrequiring modification for a long period, and it is refreshed optically when new information needs to be registered.

  9. Super-Virasoro anomaly, super-Weyl anomaly and the super-Liouville action for 2D supergravity

    CERN Document Server

    Fujiwara, T; Suzuki, T; Fujiwara, Takanori; Igarashi, Hiroshi; Suzuki, Tadao

    1996-01-01

    The relation between super-Virasoro anomaly and super-Weyl anomaly in N=1 NSR superstring coupled with 2D supergravity is investigated from canonical theoretical view point. The WZW action canceling the super-Virasoro anomaly is explicitly constructed. It is super-Weyl invariant but nonlocal functional of 2D supergravity. The nonlocality can be remedied by the super-Liouvlle action, which in turn recovers the super-Weyl anomaly. The final gravitational effective action turns out to be local but noncovariant super-Liouville action, describing the dynamical behavior of the super-Liouville fields. The BRST invariance of this approach is examined in the superconformal gauge and in the light-cone gauge.

  10. The Super-Kamiokande Experiment

    CERN Document Server

    Walter, C W

    2008-01-01

    Super-Kamiokande is a 50 kiloton water Cherenkov detector located at the Kamioka Observatory of the Institute for Cosmic Ray Research, University of Tokyo. It was designed to study neutrino oscillations and carry out searches for the decay of the nucleon. The Super-Kamiokande experiment began in 1996 and in the ensuing decade of running has produced extremely important results in the fields of atmospheric and solar neutrino oscillations, along with setting stringent limits on the decay of the nucleon and the existence of dark matter and astrophysical sources of neutrinos. Perhaps most crucially, Super-Kamiokande for the first time definitively showed that neutrinos have mass and undergo flavor oscillations. This chapter will summarize the published scientific output of the experiment with a particular emphasis on the atmospheric neutrino results.

  11. Microsphere Super-resolution Imaging

    CERN Document Server

    Wang, Zengbo

    2015-01-01

    Recently, it was discovered that microsphere can generate super-resolution focusing beyond diffraction limit. This has led to the development of an exciting super-resolution imaging technique -microsphere nanoscopy- that features a record resolution of 50 nm under white lights. Different samples have been directly imaged in high resolution and real time without labelling, including both non-biological (nano devices, structures and materials) and biological (subcellular details, viruses) samples. This chapter reviews the technique, which covers its background, fundamentals, experiments, mechanisms as well as the future outlook.

  12. Interactive Super Mario Bros Evolution

    DEFF Research Database (Denmark)

    Sørensen, Patrikk D.; Olsen, Jeppeh M.; Risi, Sebastian

    2016-01-01

    to encourage the evolution of desired behaviors. In this paper, we show how casual users can create controllers for \\emph{Super Mario Bros} through an interactive evolutionary computation (IEC) approach, without prior domain or programming knowledge. By iteratively selecting Super Mario behaviors from a set...... of candidates, users are able to guide evolution towards a variety of different behaviors, which would be difficult with an automated approach. Additionally, the user-evolved controllers perform similarly well as controllers evolved with a traditional fitness-based approach when comparing distance traveled...

  13. Quantisation of super Teichmueller theory

    Energy Technology Data Exchange (ETDEWEB)

    Aghaei, Nezhla [DESY Hamburg (Germany). Theory Group; Hamburg Univ. (Germany). Dept. of Mathematics; Pawelkiewicz, Michal; Techner, Joerg [DESY Hamburg (Germany). Theory Group

    2015-12-15

    We construct a quantisation of the Teichmueller spaces of super Riemann surfaces using coordinates associated to ideal triangulations of super Riemann surfaces. A new feature is the non-trivial dependence on the choice of a spin structure which can be encoded combinatorially in a certain refinement of the ideal triangulation. By constructing a projective unitary representation of the groupoid of changes of refined ideal triangulations we demonstrate that the dependence of the resulting quantum theory on the choice of a triangulation is inessential.

  14. Quantisation of super Teichmueller theory

    CERN Document Server

    Aghaei, Nezhla; Teschner, Joerg

    2015-01-01

    We construct a quantisation of the Teichmueller spaces of super Riemann surfaces using coordinates associated to ideal triangulations of super Riemann surfaces. A new feature is the non-trivial dependence on the choice of a spin structure which can be encoded combinatorially in a certain refinement of the ideal triangulation. By constructing a projective unitary representation of the groupoid of changes of refined ideal triangulations we demonstrate that the dependence of the resulting quantum theory on the choice of a triangulation is inessential.

  15. The construction of orthodox super rpp semigroups

    Institute of Scientific and Technical Information of China (English)

    HE Yong; GUO Yuqi; Kar Ping Shum

    2004-01-01

    We define orthodox super rpp semigroups and study their semilattice decompositions. Standard representation theorem of orthodox super rpp semigroups whose subband of idempotents is in the varieties of bands described by an identity with at most three variables are obtained.

  16. Efficient super-resolution image reconstruction applied to surveillance video captured by small unmanned aircraft systems

    Science.gov (United States)

    He, Qiang; Schultz, Richard R.; Chu, Chee-Hung Henry

    2008-04-01

    The concept surrounding super-resolution image reconstruction is to recover a highly-resolved image from a series of low-resolution images via between-frame subpixel image registration. In this paper, we propose a novel and efficient super-resolution algorithm, and then apply it to the reconstruction of real video data captured by a small Unmanned Aircraft System (UAS). Small UAS aircraft generally have a wingspan of less than four meters, so that these vehicles and their payloads can be buffeted by even light winds, resulting in potentially unstable video. This algorithm is based on a coarse-to-fine strategy, in which a coarsely super-resolved image sequence is first built from the original video data by image registration and bi-cubic interpolation between a fixed reference frame and every additional frame. It is well known that the median filter is robust to outliers. If we calculate pixel-wise medians in the coarsely super-resolved image sequence, we can restore a refined super-resolved image. The primary advantage is that this is a noniterative algorithm, unlike traditional approaches based on highly-computational iterative algorithms. Experimental results show that our coarse-to-fine super-resolution algorithm is not only robust, but also very efficient. In comparison with five well-known super-resolution algorithms, namely the robust super-resolution algorithm, bi-cubic interpolation, projection onto convex sets (POCS), the Papoulis-Gerchberg algorithm, and the iterated back projection algorithm, our proposed algorithm gives both strong efficiency and robustness, as well as good visual performance. This is particularly useful for the application of super-resolution to UAS surveillance video, where real-time processing is highly desired.

  17. Integrability in N=4 super Yang-Mills theory

    Energy Technology Data Exchange (ETDEWEB)

    Eden, B. [ITF and Spinoza Institute, University of Utrecht, Minnaertgebouw, Leuvenlaan 4, 3584 CE Utrecht (Netherlands)

    2008-10-15

    We use the Bethe ansatz to calculate the cusp anomalous dimension in planar N=4 super Yang-Mills theory as an exact function of the coupling constant. The calculation allows us to fix the remaining ambiguities in the integrable system describing the spectrum of operators/string energy levels in the AdS/CFT correspondence. The cusp anomalous dimension is not affected by finite size effects, which in general remain ill-understood. We suggest a method for computing the lowest example of an anomalous dimension modified by such corrections.

  18. Super-resolution Phase Tomography

    KAUST Repository

    Depeursinge, Christian

    2013-04-21

    Digital Holographic Microscopy (DHM) yields reconstructed complex wavefields. It allows synthesizing the aperture of a virtual microscope up to 2π, offering super-resolution phase images. Live images of micro-organisms and neurons with resolution less than 100 nm are presented.

  19. Super Rice Breeding in China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@I. Demand for super high yield rice in China   Rice is one of the main staple food in China. The performance of rice sector in production and yield had been very impressive in the last four decades. However, rice production and yield has stagnated since 1990.

  20. Super Girls Still Center Stage

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The TV singing contest continues to draw a devoted audience, but will its impact on Chinese culture fall away like a shooting star? Ask any teenage girl in China to name the finalists of last year's Super Girl show and chances are she will instantly come up with the three big names.She'll probable

  1. Analysis of Forensic Super Timelines

    Science.gov (United States)

    2012-06-14

    BIB .1  vii List of Figures Figure Page...Hacker disconnects from User’s system  User clicks off Screen Saver  User closes Solitaire program  User logs off system BIB .1...analysis- tapestry_33836. BIB .2 Guðjónsson, K. (2010). Mastering the super timeline with log2timeline. SANS Gold Paper accepted June 29,2010

  2. The SuperB Silicon Vertex Tracker and 3D vertical integration

    CERN Document Server

    Re, Valerio

    2011-01-01

    The construction of the SuperB high luminosity collider was approved and funded by the Italian government in 2011. The performance specifications set by the target luminosity of this machine (> 10^36 cm^-2 s^-1) ask for the development of a Silicon Vertex Tracker with high resolution, high tolerance to radiation and excellent capability of handling high data rates. This paper reviews the R&D activity that is being carried out for the SuperB SVT. Special emphasis is given to the option of exploiting 3D vertical integration to build advanced pixel sensors and readout electronics that are able to comply with SuperB vertexing requirements.

  3. Super Hybrid Rice

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Plant breeders realize that, up to now, there are only two effective ways to increase the yield potential of crops through breeding, i.e. morphologic improvement and heterosis utilization. However, the potential is very limited by using morphologic improvement alone, and heterosis breeding will produce undesirable results if it does not combine with morphologic improvement. Any other breeding approaches and methods including high technology like molecular breeding must be incorporated into good morphologic characters and strong heterosis, otherwise there will be no actual contributions to yield increase. On the other hand , the further development of plant breeding for high target must rely on the progress of biotechnology.

  4. Plans for Neutrino Super Beams in Europe

    CERN Document Server

    Dracos, Marcos

    2010-01-01

    Neutrino Super Beams use conventional techniques to increase the neutrino beam intensity compared to the present neutrino facilities. The first part of these facilities consists of an intense proton driver producing a beam higher than a MW power. The protons hit a target able to afford the high proton beam intensity. The produced charged particles are focused by a system of magnetic horns towards the experiment detectors. The main challenge of these projects is to produce elements able to resist to the high beam intensity for many years. New high power neutrino facilities could be build at CERN profiting from the LHC upgrades. For this reason, the initial design of these upgrades has to include the possibility to go to high power facilities.

  5. Vibration Analysis of Aeroengine Blisk Structure Based on a Prestressed CMS Super-Element Method

    Directory of Open Access Journals (Sweden)

    Zhijun Li

    2016-01-01

    Full Text Available For vibration analysis of aeroengine blisk structure, a prestressed component modal synthesis (CMS super-element method is put forward with the fixed interface prestressing and free interface super-element approach. Based on this method, natural vibration characteristics of blisk structure are calculated at different modal truncation numbers. Comparing with the accurate result of global method, the selection principle of modal truncation number is obtained which affects the accuracy of prestressed CMS super-element method. Vibration response of two-stage blisk structure is calculated by this method, and the effects of different blade aspect ratios have been discussed on vibration characteristics. The results show that prestressed CMS super-element method is in the high accuracy and efficiency on blisk vibration analysis. Resonant frequencies in vibration response are nearly the same between the first-stage blisk and the second-stage blisk, and they are both approximately located in the range 588 Hz–599 Hz. The maximum displacement and dynamic stress are at blade tip and root of the first-stage blisk, respectively. Blade aspect ratio is a key factor of blisk vibration; the effects of blade aspect ratio on natural frequencies are different in the conditions of fixed width and fixed length. This research provides the theoretical basis for dynamic design of aeroengine compressor rotor system.

  6. Propagation dynamics of super-Gaussian beams in fractional Schrödinger equation: from linear to nonlinear regimes.

    Science.gov (United States)

    Zhang, Lifu; Li, Chuxin; Zhong, Haizhe; Xu, Changwen; Lei, Dajun; Li, Ying; Fan, Dianyuan

    2016-06-27

    We have investigated the propagation dynamics of super-Gaussian optical beams in fractional Schrödinger equation. We have identified the difference between the propagation dynamics of super-Gaussian beams and that of Gaussian beams. We show that, the linear propagation dynamics of the super-Gaussian beams with order m > 1 undergo an initial compression phase before they split into two sub-beams. The sub-beams with saddle shape separate each other and their interval increases linearly with propagation distance. In the nonlinear regime, the super-Gaussian beams evolve to become a single soliton, breathing soliton or soliton pair depending on the order of super-Gaussian beams, nonlinearity, as well as the Lévy index. In two dimensions, the linear evolution of super-Gaussian beams is similar to that for one dimension case, but the initial compression of the input super-Gaussian beams and the diffraction of the splitting beams are much stronger than that for one dimension case. While the nonlinear propagation of the super-Gaussian beams becomes much more unstable compared with that for the case of one dimension. Our results show the nonlinear effects can be tuned by varying the Lévy index in the fractional Schrödinger equation for a fixed input power.

  7. Fixing Dataset Search

    Science.gov (United States)

    Lynnes, Chris

    2014-01-01

    Three current search engines are queried for ozone data at the GES DISC. The results range from sub-optimal to counter-intuitive. We propose a method to fix dataset search by implementing a robust relevancy ranking scheme. The relevancy ranking scheme is based on several heuristics culled from more than 20 years of helping users select datasets.

  8. Super-translations and super-rotations at the horizon

    CERN Document Server

    Donnay, Laura; Gonzalez, Hernan A; Pino, Miguel

    2015-01-01

    We show that the asymptotic symmetries close to non-extremal black hole horizons are generated by an extension of super-translations. This group is generated by a semi-direct sum of Virasoro and abelian currents. The charges associated to the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of the stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon.

  9. Multimodal super-resolution optical microscopy using a transition metal-based probe provides unprecedented capabilities for imaging both nucle-ar chromatin and mitochondria.

    Science.gov (United States)

    Sreedharan, Sreejesh; Gill, Martin; Garcia, Esther; Saeed, Hiwa K; Robinson, Darren; Byrne, Aisling; Cadby, Ashley James; Keyes, Tia E; Smythe, Carl G W; Pellett, Patrina; Bernardino de la Serna, Jorge; Thomas, Jim Antony

    2017-10-04

    Detailed studies on the live cell uptake properties of a dinuclear membrane permeable permeable RuII cell probe show that, at low concentrations, the complex localizes and images mitochondria. At concentrations above ~20 μM the complex images nuclear DNA. Since the complex is extremely photostable, has a large Stokes shift, and displays intrinsic subcellular targeting, its compatibility with super-resolution techniques was investigated. It was found to be very well suited to image mitochondria and nuclear chromatin in two col-our, 2C-SIM; and STED and 3D-STED both in fixed and live cell. In particular, due to its vastly improved photostability compared to conventional SR probes, it can provide images of nuclear DNA at unprecedented resolution.

  10. 伦敦SuperDesign展

    Institute of Scientific and Technical Information of China (English)

    柚子

    2011-01-01

    近日,英国伦敦Super Design展在伦敦Wakefield大街的The Dairy展厅如期举行。本次展览展出了来自包括知名设计师和新兴设计师的特别定制的工作室作品:到如今已经是第五个年头的伦敦Super Deslgn展,力图强发展,展出形式别出心裁、独树一帜,从一个崭新.活跃的角度集展示当代艺术。

  11. Super-stable Poissonian structures

    Science.gov (United States)

    Eliazar, Iddo

    2012-10-01

    In this paper we characterize classes of Poisson processes whose statistical structures are super-stable. We consider a flow generated by a one-dimensional ordinary differential equation, and an ensemble of particles ‘surfing’ the flow. The particles start from random initial positions, and are propagated along the flow by stochastic ‘wave processes’ with general statistics and general cross correlations. Setting the initial positions to be Poisson processes, we characterize the classes of Poisson processes that render the particles’ positions—at all times, and invariantly with respect to the wave processes—statistically identical to their initial positions. These Poisson processes are termed ‘super-stable’ and facilitate the generalization of the notion of stationary distributions far beyond the realm of Markov dynamics.

  12. Super-Kamiokande atmospheric neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Moriyama, S. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Higashi Mozumi, Hida city, Gifu prefecture (Japan)

    2005-08-15

    Results on atmospheric neutrino analysis at Super-Kamiokande I is presented. The whole data set of atmospheric neutrino sample in Super-Kamiokande I is consistently explained with an assumption of pure {nu}{sub {mu}}-{nu}{sub {tau}} oscillations. The allowed range of parameters is 1.5x10{sup -3}<{delta}m{sup 2}<3.4x10{sup -3} eV{sup 2} and sin{sup 2}2{theta}>0.92 at 90% C.L. In the oscillation analysis, we improved the treatment of systematic errors so that they can be considered as independent. This makes possible to find which systematic errors have larger effect on the analysis results. Some sensitivity studies under several assumptions of improvements in systematic errors are presented.

  13. Fixed textile shutters

    Directory of Open Access Journals (Sweden)

    K.A. Chernova

    2010-06-01

    Full Text Available One of the main socio-economic problems in Russia is the high cost and the poor condition of housing.Such goals as cost reduction, reducing installation time and increasing the service life of structures are accomplishing by creating new technologies of erecting buildings and developing ways ofquickconstruction, using different types of fixed formwork. One of themis textstone.Textstone is an artificial construction stone, containing on the outer surface the reinforcing fine-mesh shell with multifunctional properties, formed by the interwoven threads of a vigorous fixed formwork textile material (basalt, linen, silica and other glass yarns adhered by binding material. The innovative construction technology of production and installation of a new generation of textstone buildings has been registered as a brand TextStone. The fundamental difference between texstone and reinforced concrete and all known building materials is that the whole outer surface of solidified light binders is protected by strong, vigorous and fixed formwork made from inexpensive textile materials. Manufacturing textile shells allows using it as an internal finishing material, reducing or eliminating the cost of finishing work.The use of fixed textile construction shutters during the construction of buildings has obvious technical, economic, operational, sanitary and environmental benefits: short construction time (from 3 to 10 days, compact packaging and light weight of fabric shells, high fire resistance, frost resistance, ease of engineering services installation in the hollow communicating shells; minimal amount of finishing, roofing, heat and noise insulation works. Texstone is a durable solid monolithic construction that provides high viability and earthquakes, hurricanes wind, solar sultriness and frost resistance. Material complies with all sanitary and environmental requirements. Due to such physical, mechanical, operational, sanitary and ecological characteristics

  14. Fixed Sagittal Plane Imbalance

    OpenAIRE

    Savage, Jason W.; Patel, Alpesh A.

    2014-01-01

    Study Design Literature review. Objective To discuss the evaluation and management of fixed sagittal plane imbalance. Methods A comprehensive literature review was performed on the preoperative evaluation of patients with sagittal plane malalignment, as well as the surgical strategies to address sagittal plane deformity. Results Sagittal plane imbalance is often caused by de novo scoliosis or iatrogenic flat back deformity. Understanding the etiology and magnitude of sagittal malalignment is ...

  15. The Era of Super Capitalism

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The world has entered the "super capitalism" era when one third of its economic activities are controlled by less than 3 percent of global financial capital. This year,a global economic recession,triggered by the U.S. subprime mortgage crisis,seems unavoidable. To tackle international financial problems,Tao Dong,Chief Economist for Asia at Credit Suisse First Boston in Hong Kong,shared his insights with China Business Journal. Excerpts follow.

  16. Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

    Science.gov (United States)

    Tuononen, Katja; Mäki-Nevala, Satu; Sarhadi, Virinder Kaur; Wirtanen, Aino; Rönty, Mikko; Salmenkivi, Kaisa; Andrews, Jenny M; Telaranta-Keerie, Aino I; Hannula, Sari; Lagström, Sonja; Ellonen, Pekka; Knuuttila, Aija; Knuutila, Sakari

    2013-05-01

    The development of tyrosine kinase inhibitor treatments has made it important to test cancer patients for clinically significant gene mutations that influence the benefit of treatment. Targeted next-generation sequencing (NGS) provides a promising method for diagnostic purposes by enabling the simultaneous detection of multiple mutations in various genes in a single test. The aim of our study was to screen EGFR, KRAS, and BRAF mutations by targeted NGS and commonly used real-time polymerase chain reaction (PCR) methods to evaluate the feasibility of targeted NGS for the detection of the mutations. Furthermore, we aimed to identify potential novel mutations by targeted NGS. We analyzed formalin-fixed, paraffin-embedded (FFPE) tumor tissue specimens from 81 non-small cell lung carcinoma patients. We observed a significant concordance (from 96.3 to 100%) of the EGFR, KRAS, and BRAF mutation detection results between targeted NGS and real-time PCR. Moreover, targeted NGS revealed seven nonsynonymous single-nucleotide variations and one insertion-deletion variation in EGFR not detectable by the real-time PCR methods. The potential clinical significance of these variants requires elucidation in future studies. Our results support the use of targeted NGS in the screening of EGFR, KRAS, and BRAF mutations in FFPE tissue material.

  17. BEWARE OF...SUPER GLUES!!

    CERN Multimedia

    2006-01-01

    What happened? A number of accidents have occurred with the use of 'Super Glues'. Some individuals have suffered injuries - severe irritation, or skin bonded together - through getting glue on their face and in their eyes. What are the hazards associated with glues? 'Super Glues' (i.e. cyanoacrylates): Are harmful if swallowed and are chemical irritants to the eyes, respiratory system and skin. Present the risk of polymerization (hardening) leading to skin damage. Be careful ! 'Super Glues' can bond to skin and eyes in seconds. Note: Other glues, resins and hardeners are also chemicals and as such can cause serious damage to the skin, eyes, respiratory or digestive tract. (For example: some components can be toxic, harmful, corrosive, sensitizing agents, etc.). How to prevent accidents in the future? Read the Material Safety Data Sheet (MSDS) for all of the glues you work with. Check the label on the container to find out which of the materials you work with are hazardous. Wear the right Per...

  18. Generation of warm dense matter and strongly coupled plasmas using the High Radiation on Materials facility at the CERN Super Proton Synchrotron

    CERN Document Server

    Tahir, N A; Brugger, M; Assmann, R; Shutov, A; Lomonosov, I V; Gryaznov, V; Piriz, A R; Udrea, S; Hoffmann, D H H; Fortov, V E; Deutsch, C

    2009-01-01

    A dedicated facility named High Radiation on Materials (HiRadMat) is being constructed at CERN to study the interaction of the 450 GeV protons generated by the Super Proton Synchrotron (SPS) with fixed solid targets of different materials. The main purpose of these future experiments is to study the generation and propagation of thermal shock waves in the target in order to assess the damage caused to the equipment, including collimators and absorbers, in case of an accident involving an uncontrolled release of the entire beam at a given point. Detailed numerical simulations of the beam-target interaction of several cases of interest have been carried out. In this paper we present simulations of the thermodynamic and the hydrodynamic response of a solid tungsten cylindrical target that is facially irradiated with the SPS beam with nominal parameters. These calculations have been carried out in two steps. First, the energy loss of the protons is calculated in the solid target using the FLUKA code (Fasso et al....

  19. Watching the Birth of Super Star Clusters

    CERN Document Server

    Turner, J L; Turner, Jean L.; Beck, Sara C.

    2003-01-01

    Subarcsecond infrared and radio observations yield important information about the formation of super star clusters from their surrounding gas. We discuss the general properties of ionized and molecular gas near young, forming SSCs, as illustrated by the prototypical young forming super star cluster nebula in the dwarf galaxy, NGC 5253. This super star cluster appears to have a gravitationally bound nebula. The lack of molecular gas suggests a very high star formation efficiency, consistent with the formation of a large, bound star cluster.

  20. Fixed-Term Homotopy

    Directory of Open Access Journals (Sweden)

    Hector Vazquez-Leal

    2013-01-01

    Full Text Available A new tool for the solution of nonlinear differential equations is presented. The Fixed-Term Homotopy (FTH delivers a high precision representation of the nonlinear differential equation using only a few linear algebraic terms. In addition to this tool, a procedure based on Laplace-Padé to deal with the truncate power series resulting from the FTH method is also proposed. In order to assess the benefits of this proposal, two nonlinear problems are solved and compared against other semianalytic methods. The obtained results show that FTH is a power tool capable of generating highly accurate solutions compared with other methods of literature.

  1. Fixed and Sunk Costs Revisited.

    Science.gov (United States)

    Wang, X. Henry; Yang, Bill Z.

    2001-01-01

    Attempts to clarify the concepts of, and the link between, fixed costs and sunk costs. Argues that the root of confusion is the inconsistency in defining the term fixed costs. Consistently defines fixed and sunk costs, and describes how instructors must teach under these definitions. (RLH)

  2. Two-Component Super AKNS Equations and Their Finite-Dimensional Integrable Super Hamiltonian System

    OpenAIRE

    Jing Yu; Jingwei Han

    2014-01-01

    Starting from a matrix Lie superalgebra, two-component super AKNS system is constructed. By making use of monononlinearization technique of Lax pairs, we find that the obtained two-component super AKNS system is a finite-dimensional integrable super Hamiltonian system. And its Lax representation and $r$ -matrix are also given in this paper.

  3. Two-Component Super AKNS Equations and Their Finite-Dimensional Integrable Super Hamiltonian System

    Directory of Open Access Journals (Sweden)

    Jing Yu

    2014-01-01

    Full Text Available Starting from a matrix Lie superalgebra, two-component super AKNS system is constructed. By making use of monononlinearization technique of Lax pairs, we find that the obtained two-component super AKNS system is a finite-dimensional integrable super Hamiltonian system. And its Lax representation and r-matrix are also given in this paper.

  4. Fixed sagittal plane imbalance.

    Science.gov (United States)

    Savage, Jason W; Patel, Alpesh A

    2014-12-01

    Study Design Literature review. Objective To discuss the evaluation and management of fixed sagittal plane imbalance. Methods A comprehensive literature review was performed on the preoperative evaluation of patients with sagittal plane malalignment, as well as the surgical strategies to address sagittal plane deformity. Results Sagittal plane imbalance is often caused by de novo scoliosis or iatrogenic flat back deformity. Understanding the etiology and magnitude of sagittal malalignment is crucial in realignment planning. Objective parameters have been developed to guide surgeons in determining how much correction is needed to achieve favorable outcomes. Currently, the goals of surgery are to restore a sagittal vertical axis Sagittal plane malalignment is an increasingly recognized cause of pain and disability. Treatment of sagittal plane imbalance varies according to the etiology, location, and severity of the deformity. Fixed sagittal malalignment often requires complex reconstructive procedures that include osteotomy correction. Reestablishing harmonious spinopelvic alignment is associated with significant improvement in health-related quality-of-life outcome measures and patient satisfaction.

  5. The Complete One-Loop Dilation Operator of N=2 SuperConformal QCD

    CERN Document Server

    Liendo, Pedro; Rastelli, Leonardo

    2011-01-01

    We evaluate the full planar one-loop dilation operator of N=2 SuperConformal QCD, the SU(N_c) super Yang-Mills theory with N_f = 2 N_c fundamental hypermultiplets, in the flavor-singlet sector. Remarkably, the spin-chain Hamiltonian turns out to be completely fixed by superconformal symmetry, as in N=4 SYM. We present a more general calculation, for the superconformal quiver theory with SU(N_c)X SU(N_c) gauge group, which interpolates between N=2 SCQCD and the Z_2 orbifold of N=4 SYM; here symmetry fixes the Hamiltonian up to a single parameter, corresponding to the ratio of the two marginal gauge couplings.

  6. Highlights from Super-Kamiokande

    Science.gov (United States)

    Okumura, Kimihiro

    2016-11-01

    Recent results from Super-Kamiokande experiment are reviewed in this paper; Neutrino mass hierarchy and CP violation in the lepton sector are investigated via νμ → νe oscillation of the atmospheric neutrinos. The event rate, correlation with solar activity, energy spectrum of the solar neutrinos are measured via electron elastic scattering interactions. Neutrino emission from the WIMP annihilation at the center of the Sun are searched in the GeV energy regions. New project, SK-Gd project, to enhance anti-neutrino identification capability, has been approved inside the collaboration group.

  7. Highlights from Super-Kamiokande

    Directory of Open Access Journals (Sweden)

    Okumura Kimihiro

    2016-01-01

    Full Text Available Recent results from Super-Kamiokande experiment are reviewed in this paper; Neutrino mass hierarchy and CP violation in the lepton sector are investigated via νμ → νe oscillation of the atmospheric neutrinos. The event rate, correlation with solar activity, energy spectrum of the solar neutrinos are measured via electron elastic scattering interactions. Neutrino emission from the WIMP annihilation at the center of the Sun are searched in the GeV energy regions. New project, SK-Gd project, to enhance anti-neutrino identification capability, has been approved inside the collaboration group.

  8. A microfluidic platform for correlative live-cell and super-resolution microscopy.

    Directory of Open Access Journals (Sweden)

    Johnny Tam

    Full Text Available Recently, super-resolution microscopy methods such as stochastic optical reconstruction microscopy (STORM have enabled visualization of subcellular structures below the optical resolution limit. Due to the poor temporal resolution, however, these methods have mostly been used to image fixed cells or dynamic processes that evolve on slow time-scales. In particular, fast dynamic processes and their relationship to the underlying ultrastructure or nanoscale protein organization cannot be discerned. To overcome this limitation, we have recently developed a correlative and sequential imaging method that combines live-cell and super-resolution microscopy. This approach adds dynamic background to ultrastructural images providing a new dimension to the interpretation of super-resolution data. However, currently, it suffers from the need to carry out tedious steps of sample preparation manually. To alleviate this problem, we implemented a simple and versatile microfluidic platform that streamlines the sample preparation steps in between live-cell and super-resolution imaging. The platform is based on a microfluidic chip with parallel, miniaturized imaging chambers and an automated fluid-injection device, which delivers a precise amount of a specified reagent to the selected imaging chamber at a specific time within the experiment. We demonstrate that this system can be used for live-cell imaging, automated fixation, and immunostaining of adherent mammalian cells in situ followed by STORM imaging. We further demonstrate an application by correlating mitochondrial dynamics, morphology, and nanoscale mitochondrial protein distribution in live and super-resolution images.

  9. A microfluidic platform for correlative live-cell and super-resolution microscopy.

    Science.gov (United States)

    Tam, Johnny; Cordier, Guillaume Alan; Bálint, Štefan; Sandoval Álvarez, Ángel; Borbely, Joseph Steven; Lakadamyali, Melike

    2014-01-01

    Recently, super-resolution microscopy methods such as stochastic optical reconstruction microscopy (STORM) have enabled visualization of subcellular structures below the optical resolution limit. Due to the poor temporal resolution, however, these methods have mostly been used to image fixed cells or dynamic processes that evolve on slow time-scales. In particular, fast dynamic processes and their relationship to the underlying ultrastructure or nanoscale protein organization cannot be discerned. To overcome this limitation, we have recently developed a correlative and sequential imaging method that combines live-cell and super-resolution microscopy. This approach adds dynamic background to ultrastructural images providing a new dimension to the interpretation of super-resolution data. However, currently, it suffers from the need to carry out tedious steps of sample preparation manually. To alleviate this problem, we implemented a simple and versatile microfluidic platform that streamlines the sample preparation steps in between live-cell and super-resolution imaging. The platform is based on a microfluidic chip with parallel, miniaturized imaging chambers and an automated fluid-injection device, which delivers a precise amount of a specified reagent to the selected imaging chamber at a specific time within the experiment. We demonstrate that this system can be used for live-cell imaging, automated fixation, and immunostaining of adherent mammalian cells in situ followed by STORM imaging. We further demonstrate an application by correlating mitochondrial dynamics, morphology, and nanoscale mitochondrial protein distribution in live and super-resolution images.

  10. Laparoscopic adjustable banded roux-en-y gastric bypass as a primary procedure for the super-super-obese (body mass index > 60 kg/m2

    Directory of Open Access Journals (Sweden)

    Van Dessel Els

    2010-11-01

    Full Text Available Abstract Background Currently, there is no consensus opinion regarding the optimal procedure of choice in super-super-morbid obesity (Body mass index, BMI > 60 kg/m2. Roux-en-Y gastric bypass (RYGB is associated with failure to achieve or maintain 50% excess weight loss (EWL or BMI 35 following RYGB surgery in this group. The addition of adjustable gastric band (AGB to RYGB has been reported as a revisional procedure but this combined bariatric procedure has not been explored as a primary operation. Methods In a primary laparoscopic RYGB, an AGB is drawn around the gastric pouch through a small opening between the blood vessels on the lesser curve and the gastric pouch. The band is then fixed by suturing the gastric remnant to the gastric pouch both above and below the band to prevent slippage. Results Between November 2009 and March 2010, 6 consecutive super-super-obese patients underwent a primary laparoscopic adjustable banded Roux-en-Y gastric bypass procedure at our institution. One male patient (21 years, BMI 70 kg/m² developed a pneumonia postoperatively. No other postoperative complications were observed. Conclusion To the best of our knowledge, this is the first series of patients that underwent a laparoscopic adjustable banded RYGB as a primary operation for the super-super obese in the indexed literature. With the combined procedure, a sequential action mechanism for weight loss is to be expected. The restrictive, malabsorptive and hormonal working mechanism of the RYGB will induce weight loss from the start reaching a stabilised plateau of weight after 12 - 18 months. At that time, filling of the band can be started resulting in further gastric pouch restriction and increased weight loss. Moreover, besides improving the results of total weight loss, a gradual filling of the band can as well prevent the RYGB patient from weight regain if restriction would fade away with time.

  11. Fixed Access Network Sharing

    Science.gov (United States)

    Cornaglia, Bruno; Young, Gavin; Marchetta, Antonio

    2015-12-01

    Fixed broadband network deployments are moving inexorably to the use of Next Generation Access (NGA) technologies and architectures. These NGA deployments involve building fiber infrastructure increasingly closer to the customer in order to increase the proportion of fiber on the customer's access connection (Fibre-To-The-Home/Building/Door/Cabinet… i.e. FTTx). This increases the speed of services that can be sold and will be increasingly required to meet the demands of new generations of video services as we evolve from HDTV to "Ultra-HD TV" with 4k and 8k lines of video resolution. However, building fiber access networks is a costly endeavor. It requires significant capital in order to cover any significant geographic coverage. Hence many companies are forming partnerships and joint-ventures in order to share the NGA network construction costs. One form of such a partnership involves two companies agreeing to each build to cover a certain geographic area and then "cross-selling" NGA products to each other in order to access customers within their partner's footprint (NGA coverage area). This is tantamount to a bi-lateral wholesale partnership. The concept of Fixed Access Network Sharing (FANS) is to address the possibility of sharing infrastructure with a high degree of flexibility for all network operators involved. By providing greater configuration control over the NGA network infrastructure, the service provider has a greater ability to define the network and hence to define their product capabilities at the active layer. This gives the service provider partners greater product development autonomy plus the ability to differentiate from each other at the active network layer.

  12. Optical trapping with Super-Gaussian beams

    CSIR Research Space (South Africa)

    McLaren, M

    2013-04-01

    Full Text Available We outline the possibility of optical trapping and tweezing with Super-Gaussian beam profiles. We show that the trapping strength can be tuned continuously by adjusting the order of a Super-Gaussian beam, approaching that of a perfect Gaussian...

  13. Tetrahedral Units: For Dodecahedral Super-Structures

    CERN Document Server

    Ortiz, Y; Liebman, J F

    2016-01-01

    Different novel organic-chemical possibilities for tetrahedral building units are considered, with attention to their utility in constructing different super-structures. As a representative construction we consider the use of sets of 20 such identical tetrahedral units to form a super-dodecahedron.

  14. dbSUPER: a database of super-enhancers in mouse and human genome.

    Science.gov (United States)

    Khan, Aziz; Zhang, Xuegong

    2016-01-04

    Super-enhancers are clusters of transcriptional enhancers that drive cell-type-specific gene expression and are crucial to cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, a centralized resource to integrate all these findings is not currently available. We developed dbSUPER (http://bioinfo.au.tsinghua.edu.cn/dbsuper/), the first integrated and interactive database of super-enhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to Galaxy instances, GREAT and Cistrome web-servers for downstream analysis, and can also be visualized in the UCSC genome browser where custom tracks can be added automatically. The data can be downloaded and exported in variety of formats. Furthermore, dbSUPER lists genes associated with super-enhancers and also links to external databases such as GeneCards, UniProt and Entrez. dbSUPER also provides an overlap analysis tool to annotate user-defined regions. We believe dbSUPER is a valuable resource for the biology and genetic research communities.

  15. Ending Aging in Super Glassy Polymer Membranes

    Energy Technology Data Exchange (ETDEWEB)

    Lau, CH; Nguyen, PT; Hill, MR; Thornton, AW; Konstas, K; Doherty, CM; Mulder, RJ; Bourgeois, L; Liu, ACY; Sprouster, DJ; Sullivan, JP; Bastow, TJ; Hill, AJ; Gin, DL; Noble, RD

    2014-04-16

    Aging in super glassy polymers such as poly(trimethylsilylpropyne) (PTMSP), poly(4-methyl-2-pentyne) (PMP), and polymers with intrinsic microporosity (PIM-1) reduces gas permeabilities and limits their application as gas-separation membranes. While super glassy polymers are initially very porous, and ultra-permeable, they quickly pack into a denser phase becoming less porous and permeable. This age-old problem has been solved by adding an ultraporous additive that maintains the low density, porous, initial stage of super glassy polymers through absorbing a portion of the polymer chains within its pores thereby holding the chains in their open position. This result is the first time that aging in super glassy polymers is inhibited whilst maintaining enhanced CO2 permeability for one year and improving CO2/N-2 selectivity. This approach could allow super glassy polymers to be revisited for commercial application in gas separations.

  16. Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes.

    Science.gov (United States)

    Blinka, Steven; Reimer, Michael H; Pulakanti, Kirthi; Rao, Sridhar

    2016-09-27

    Super-enhancers are tissue-specific cis-regulatory elements that drive expression of genes associated with cell identity and malignancy. A cardinal feature of super-enhancers is that they are transcribed to produce enhancer-derived RNAs (eRNAs). It remains unclear whether super-enhancers robustly activate genes in situ and whether their functions are attributable to eRNAs or the DNA element. CRISPR/Cas9 was used to systematically delete three discrete super-enhancers at the Nanog locus in embryonic stem cells, revealing functional differences in Nanog transcriptional regulation. One distal super-enhancer 45 kb upstream of Nanog (-45 enhancer) regulates both nearest neighbor genes, Nanog and Dppa3. Interestingly, eRNAs produced at the -45 enhancer specifically regulate Dppa3 expression by stabilizing looping of the -45 enhancer and Dppa3. Our work illustrates that genomic editing is required to determine enhancer function and points to a method to selectively target a subset of super-enhancer-regulated genes by depleting eRNAs.

  17. Super Hybrid Rice Breeding in China: Achievements and Prospects

    Institute of Scientific and Technical Information of China (English)

    Shi-Hua Cheng; Li-Yong Cao; Jie-Yun Zhuang; Shen-Guang Chen; Xiao-Deng Zhan; Ye-Yang Fan; De-Feng Zhu; Shao-Kai Min

    2007-01-01

    Hybrid rice has contributed greatly to the self-sufficiency of food supply in China. To meet the future demand for rice production, a national program on super rice breeding was established in China in 1996. The corresponding targets, breeding strategies and most significant advances are reviewed in this paper. New plant type models have been modified to adjust to various rice growing regions. In recognition of the importance of applying parents with intermediate subspecies differentiation in increasing F1 yield, medium type parental lines were selected from populations derived from inter-subspecies crosses with the assistance of DMA markers for subspecies differentiation. Results also indicate that a substantial increase of biomass is the basis for further enhancement of the grain yield potential, and amelioration of leaf characteristics is helpful in increasing the photosynthetic rate. Thirty-four super hybrid rice varieties have been released commercially, growing in a total area of 13.5 million hm2 and producing 6.7 thousand million kg more rice in 1998-2005. Although remarkable progress has been made in super hybrid rice breeding in China, selections on the root system and integration of more biotechnological tools remain a great challenge.

  18. Calibration of the Super-Kamiokande Detector

    CERN Document Server

    Abe, K; Iida, T; Iyogi, K; Kameda, J; Kishimoto, Y; Koshio, Y; Marti, Ll; Miura, M; Moriyama, S; Nakahata, M; Nakano, Y; Nakayama, S; Obayashi, Y; Sekiya, H; Shiozawa, M; Suzuki, Y; Takeda, A; Takenaga, Y; Tanaka, H; Tomura, T; Ueno, K; Wendell, R A; Yokozawa, T; Irvine, T J; Kaji, H; Kajita, T; Kaneyuki, K; Lee, K P; Nishimura, Y; Okumura, K; McLachlan, T; Labarga, L; Kearns, E; Raaf, J L; Stone, J L; Sulak, L R; Berkman, S; Tanaka, H A; Tobayama, S; Goldhaber, M; Bays, K; Carminati, G; Kropp, W R; Mine, S; Renshaw, A; Smy, M B; Sobel, H W; Ganezer, K S; Hill, J; Keig, W E; Jang, J S; Kim, J Y; Lim, I T; Hong, N; Akiri, T; Albert, J B; Himmel, A; Scholberg, K; Walter, C W; Wongjirad, T; Ishizuka, T; Tasaka, S; Learned, J G; Matsuno, S; Smith, S N; Hasegawa, T; Ishida, T; Ishii, T; Kobayashi, T; Nakadaira, T; Nakamura, K; Nishikawa, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Suzuki, A T; Takeuchi, Y; Huang, K; Ieki, K; Ikeda, M; Kikawa, T; Kubo, H; Minamino, A; Murakami, A; Nakaya, T; Otani, M; Suzuki, K; Takahashi, S; Fukuda, Y; Choi, K; Itow, Y; Mitsuka, G; Miyake, M; Mijakowski, P; Tacik, R; Hignight, J; Imber, J; Jung, C K; Taylor, I; Yanagisawa, C; Idehara, Y; Ishino, H; Kibayashi, A; Mori, T; Sakuda, M; Yamaguchi, R; Yano, T; Kuno, Y; Kim, S B; Yang, B S; Okazawa, H; Choi, Y; Nishijima, K; Koshiba, M; Totsuka, Y; Yokoyama, M; Martens, K; Vagins, M R; Martin, J F; de Perio, P; Konaka, A; Wilking, M J; Chen, S; Heng, Y; Sui, H; Yang, Z; Zhang, H; Zhenwei, Y; Connolly, K; Dziomba, M; Wilkes, R J

    2013-01-01

    Procedures and results on hardware level detector calibration in Super-Kamiokande (SK) are presented in this paper. In particular, we report improvements made in our calibration methods for the experimental phase IV in which new readout electronics have been operating since 2008. The topics are separated into two parts. The first part describes the determination of constants needed to interpret the digitized output of our electronics so that we can obtain physical numbers such as photon counts and their arrival times for each photomultiplier tube (PMT). In this context, we developed an in-situ procedure to determine high-voltage settings for PMTs in large detectors like SK, as well as a new method for measuring PMT quantum efficiency and gain in such a detector. The second part describes the modeling of the detector in our Monte Carlo simulation, including in particular the optical properties of its water target and their variability over time. Detailed studies on the water quality are also presented. As a re...

  19. Targeting of a Fixed Bacterial Immunogen to Fc Receptors Reverses the Anti-Inflammatory Properties of the Gram-Negative Bacterium, Francisella tularensis, during the Early Stages of Infection.

    Directory of Open Access Journals (Sweden)

    Zulfia Babadjanova

    Full Text Available Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including Francisella tularensis, the agent of tularemia, utilize the anti-inflammatory cytokine IL-10, to evade the host immune response. It is well established that IL-10 has the ability to inhibit robust antigen presentation by dendritic cells and macrophages, thus suppressing the generation of protective immunity. The pathogenesis of F. tularensis is not fully understood, and research has failed to develop an effective vaccine to this date. In the current study, we hypothesized that F. tularensis polarizes antigen presenting cells during the early stages of infection towards an anti-inflammatory status characterized by increased synthesis of IL-10 and decreased production of IL-12p70 and TNF-α in an IFN-ɣ-dependent fashion. In addition, F. tularensis drives an alternative activation of alveolar macrophages within the first 48 hours post-infection, thus allowing the bacterium to avoid protective immunity. Furthermore, we demonstrate that targeting inactivated F. tularensis (iFt to Fcγ receptors (FcɣRs via intranasal immunization with mAb-iFt complexes, a proven vaccine strategy in our laboratories, reverses the anti-inflammatory effects of the bacterium on macrophages by down-regulating production of IL-10. More specifically, we observed that targeting of iFt to FcγRs enhances the classical activation of macrophages not only within the respiratory mucosa, but also systemically, at the early stages of infection. These results provide important insight for further understanding the protective immune mechanisms generated when targeting immunogens to Fc receptors.

  20. Projected Sensitivity of the SuperCDMS SNOLAB experiment

    CERN Document Server

    Agnese, R; Aramaki, T; Arnquist, I; Baker, W; Barker, D; Thakur, R Basu; Bauer, D A; Borgland, A; Bowles, M A; Brink, P L; Bunker, R; Cabrera, B; Caldwell, D O; Calkins, R; Cartaro, C; Cerdeño, D G; Chagani, H; Chen, Y; Cooley, J; Cornell, B; Cushman, P; Daal, M; Di Stefano, P C F; Doughty, T; Esteban, L; Fallows, S; Figueroa-Feliciano, E; Fritts, M; Gerbier, G; Ghaith, M; Godfrey, G L; Golwala, S R; Hall, J; Harris, H R; Hofer, T; Holmgren, D; Hong, Z; Hoppe, E; Hsu, L; Huber, M E; Iyer, V; Jardin, D; Jastram, A; Kelsey, M H; Kennedy, A; Kubik, A; Kurinsky, N A; Leder, A; Loer, B; Asamar, E Lopez; Lukens, P; Mahapatra, R; Mandic, V; Mast, N; Mirabolfathi, N; Moffatt, R A; Mendoza, J D Morales; Orrell, J L; Oser, S M; Page, K; Page, W A; Partridge, R; Pepin, M; Phipps, A; Poudel, S; Pyle, M; Qiu, H; Rau, W; Redl, P; Reisetter, A; Roberts, A; Robinson, A E; Rogers, H E; Saab, T; Sadoulet, B; Sander, J; Schneck, K; Schnee, R W; Serfass, B; Speller, D; Stein, M; Street, J; Tanaka, H A; Toback, D; Underwood, R; Villano, A N; von Krosigk, B; Welliver, B; Wilson, J S; Wright, D H; Yellin, S; Yen, J J; Young, B A; Zhang, X; Zhao, X

    2016-01-01

    SuperCDMS SNOLAB will be a next-generation experiment aimed at directly detecting low-mass ( 5 GeV/c$^2$). The mix of detector types (HV and iZIP), and targets (germanium and silicon), planned for the experiment, as well as flexibility in how the detectors are operated, will allow us to maximize the low-mass reach, and understand the backgrounds that the experiment will encounter. Upgrades to the experiment, perhaps with a variety of ultra-low-background cryogenic detectors, will extend dark matter sensitivity down to the "neutrino floor", where coherent scatters of solar neutrinos become a limiting background.

  1. From world-sheet supersymmetry to super target spaces

    Energy Technology Data Exchange (ETDEWEB)

    Creutzig, Thomas [North Carolina Univ., Chapel Hill (United States). Dept. of Physics and Astronomy; Roenne, Peter B. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Witwatersrand Univ. (South Africa). National Inst. for Theoretical Physics and Centre for Theoretical Physics

    2010-07-15

    We investigate the relation between N=(2,2) superconformal Lie group WZNW models and Lie supergroup WZNW models. The B-twist of an exactly marginal perturbation of the world-sheet superconformal sigma model is the supergroup model. Moreover, the superconformal currents are expressed in terms of Lie superalgebra currents in the twisted theory. As applications, we find protected sectors and boundary actions in the supergroup sigma model. A special example is the relation between string theory on AdS{sub 3} x S{sup 3} x T{sup 4} in the RNS formalism and the U(1,1 vertical stroke 2) x U(1 vertical stroke 1) x U(1 vertical stroke 1) supergroup WZNW model. (orig.)

  2. SuperB Progress Report for Physics

    Energy Technology Data Exchange (ETDEWEB)

    O' Leary, B.; /Aachen, Tech. Hochsch.; Matias, J.; Ramon, M.; /Barcelona, IFAE; Pous, E.; /Barcelona U.; De Fazio, F.; Palano, A.; /INFN, Bari; Eigen, G.; /Bergen U.; Asgeirsson, D.; /British Columbia U.; Cheng, C.H.; Chivukula, A.; Echenard, B.; Hitlin, D.G.; Porter, F.; Rakitin, A.; /Caltech; Heinemeyer, S.; /Cantabria Inst. of Phys.; McElrath, B.; /CERN; Andreassen, R.; Meadows, B.; Sokoloff, M.; /Cincinnati U.; Blanke, M.; /Cornell U., Phys. Dept.; Lesiak, T.; /Cracow, INP /DESY /Zurich, ETH /INFN, Ferrara /Frascati /INFN, Genoa /Glasgow U. /Indiana U. /Mainz U., Inst. Phys. /Karlsruhe, Inst. Technol. /KEK, Tsukuba /LBL, Berkeley /UC, Berkeley /Lisbon, IST /Ljubljana U. /Madrid, Autonoma U. /Maryland U. /MIT /INFN, Milan /McGill U. /Munich, Tech. U. /Notre Dame U. /PNL, Richland /INFN, Padua /Paris U., VI-VII /Orsay, LAL /Orsay, LPT /INFN, Pavia /INFN, Perugia /INFN, Pisa /Queen Mary, U. of London /Regensburg U. /Republica U., Montevideo /Frascati /INFN, Rome /INFN, Rome /INFN, Rome /Rutherford /Sassari U. /Siegen U. /SLAC /Southern Methodist U. /Tel Aviv U. /Tohoku U. /INFN, Turin /INFN, Trieste /Uppsala U. /Valencia U., IFIC /Victoria U. /Wayne State U. /Wisconsin U., Madison

    2012-02-14

    SuperB is a high luminosity e{sup +}e{sup -} collider that will be able to indirectly probe new physics at energy scales far beyond the reach of any man made accelerator planned or in existence. Just as detailed understanding of the Standard Model of particle physics was developed from stringent constraints imposed by flavour changing processes between quarks, the detailed structure of any new physics is severely constrained by flavour processes. In order to elucidate this structure it is necessary to perform a number of complementary studies of a set of golden channels. With these measurements in hand, the pattern of deviations from the Standard Model behavior can be used as a test of the structure of new physics. If new physics is found at the LHC, then the many golden measurements from SuperB will help decode the subtle nature of the new physics. However if no new particles are found at the LHC, SuperB will be able to search for new physics at energy scales up to 10-100 TeV. In either scenario, flavour physics measurements that can be made at SuperB play a pivotal role in understanding the nature of physics beyond the Standard Model. Examples for using the interplay between measurements to discriminate New Physics models are discussed in this document. SuperB is a Super Flavour Factory, in addition to studying large samples of B{sub u,d,s}, D and {tau} decays, SuperB has a broad physics programme that includes spectroscopy both in terms of the Standard Model and exotica, and precision measurements of sin{sup 2} {theta}{sub W}. In addition to performing CP violation measurements at the {Upsilon}(4S) and {phi}(3770), SuperB will test CPT in these systems, and lepton universality in a number of different processes. The multitude of rare decay measurements possible at SuperB can be used to constrain scenarios of physics beyond the Standard Model. In terms of other precision tests of the Standard Model, this experiment will be able to perform precision over

  3. The superB silicon vertex tracker

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, G., E-mail: giuliana.rizzo@pi.infn.i [INFN-Pisa and Universita di Pisa (Italy); Avanzini, C.; Batignani, G.; Bettarini, S.; Bosi, F.; Calderini, G.; Ceccanti, M.; Cenci, R.; Cervelli, A.; Crescioli, F.; Dell' Orso, M.; Forti, F.; Giannetti, P.; Giorgi, M.A. [INFN-Pisa and Universita di Pisa (Italy); Lusiani, A. [Scuola Normale Superiore and INFN-Pisa (Italy); Gregucci, S.; Mammini, P.; Marchiori, G.; Massa, M.; Morsani, F. [INFN-Pisa and Universita di Pisa (Italy)

    2010-05-21

    The SuperB asymmetric e{sup +}-e{sup -} collider has been designed to deliver a luminosity greater than 10{sup 36}cm{sup -2}s{sup -1} with moderate beam currents. Comparing to current B-Factories, the reduced center of mass boost of the SuperB machine requires improved vertex resolution to allow precision measurements sensitive to New Physics. We present the conceptual design of the silicon vertex tracker (SVT) for the SuperB detector with the present status of the R and D on the different options under study for its innermost Layer0.

  4. Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

    Science.gov (United States)

    Kell, Douglas B

    2013-12-01

    Despite the sequencing of the human genome, the rate of innovative and successful drug discovery in the pharmaceutical industry has continued to decrease. Leaving aside regulatory matters, the fundamental and interlinked intellectual issues proposed to be largely responsible for this are: (a) the move from 'function-first' to 'target-first' methods of screening and drug discovery; (b) the belief that successful drugs should and do interact solely with single, individual targets, despite natural evolution's selection for biochemical networks that are robust to individual parameter changes; (c) an over-reliance on the rule-of-5 to constrain biophysical and chemical properties of drug libraries; (d) the general abandoning of natural products that do not obey the rule-of-5; (e) an incorrect belief that drugs diffuse passively into (and presumably out of) cells across the bilayers portions of membranes, according to their lipophilicity; (f) a widespread failure to recognize the overwhelmingly important role of proteinaceous transporters, as well as their expression profiles, in determining drug distribution in and between different tissues and individual patients; and (g) the general failure to use engineering principles to model biology in parallel with performing 'wet' experiments, such that 'what if?' experiments can be performed in silico to assess the likely success of any strategy. These facts/ideas are illustrated with a reasonably extensive literature review. Success in turning round drug discovery consequently requires: (a) decent systems biology models of human biochemical networks; (b) the use of these (iteratively with experiments) to model how drugs need to interact with multiple targets to have substantive effects on the phenotype; (c) the adoption of polypharmacology and/or cocktails of drugs as a desirable goal in itself; (d) the incorporation of drug transporters into systems biology models, en route to full and multiscale systems biology models that

  5. N=2 Super - $W_{3}$ Algebra and N=2 Super Boussinesq Equations

    CERN Document Server

    Ivanov, E; Malik, R P

    1995-01-01

    We study classical $N=2$ super-$W_3$ algebra and its interplay with $N=2$ supersymmetric extensions of the Boussinesq equation in the framework of the nonlinear realization method and the inverse Higgs - covariant reduction approach. These techniques have been previously applied by us in the bosonic $W_3$ case to give a new geometric interpretation of the Boussinesq hierarchy. Here we deduce the most general $N=2$ super Boussinesq equation and two kinds of the modified $N=2$ super Boussinesq equations, as well as the super Miura maps relating these systems to each other, by applying the covariant reduction to certain coset manifolds of linear $N=2$ super-$W_3^{\\infty}$ symmetry associated with $N=2$ super-$W_3$. We discuss the integrability properties of the equations obtained and their correspondence with the formulation based on the notion of the second hamiltonian structure.

  6. High resolution FISH on super-stretched flow-sorted plant chromosomes.

    NARCIS (Netherlands)

    Valárik, M.; Bartos, J.; Kovarova, P.; Kubalakova, M.; Jong, de J.H.S.G.M.; Dolezel, J.

    2004-01-01

    A novel high-resolution fluorescence in situ hybridisation (FISH) strategy, using super-stretched flow-sorted plant chromosomes as targets, is described. The technique that allows longitudinal extension of chromosomes of more than 100 times their original metaphase size is especially attractive for

  7. Technical report on the design, construction, commissioning and operation of the super-FRS of FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Geissel, H.; Winkler, M.; Weick, H. [and others

    2005-04-01

    In this report the construction of the super-FRS is described. Especially described are the ion-optical lay-out, the production targets, the magnets, the beam dumps, the degrader systems and the ion catcher, detectors and data-acquisition systems, as well as the safety aspects. (HSI)

  8. Survival and compound nucleus probability of super heavy element Z = 117

    Energy Technology Data Exchange (ETDEWEB)

    Manjunatha, H.C. [Government College for Women, Department of Physics, Kolar, Karnataka (India); Sridhar, K.N. [Government First grade College, Department of Physics, Kolar, Karnataka (India)

    2017-05-15

    As a part of a systematic study for predicting the most suitable projectile-target combinations for heavy-ion fusion experiments in the synthesis of {sup 289-297}Ts, we have calculated the transmission probability (T{sub l}), compound nucleus formation probabilities (P{sub CN}) and survival probability (P{sub sur}) of possible projectile-target combinations. We have also studied the fusion cross section, survival cross section and fission cross sections for different projectile-target combination of {sup 289-297}Ts. These theoretical parameters are required before the synthesis of the super heavy element. The calculated probabilities and cross sections show that the production of isotopes of the super heavy element with Z = 117 is strongly dependent on the reaction systems. The most probable reactions to synthetize the super heavy nuclei {sup 289-297}Ts are worked out and listed explicitly. We have also studied the variation of P{sub CN} and P{sub sur} with the mass number of projectile and target nuclei. This work is useful in the synthesis of the super heavy element Z = 117. (orig.)

  9. PDF fit in the fixed-flavour-number scheme

    Energy Technology Data Exchange (ETDEWEB)

    Alekhin, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Institute for High Energy Physics, Moscow (Russian Federation); Bluemlein, J.; Moch, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2012-02-15

    We discuss the heavy-quark contribution to deep inelastic scattering in the scheme with n{sub f}=3;4;5 fixed flavors. Based on the recent ABM11 PDF analysis of world data for deep-inelastic scattering and fixed-target data for the Drell-Yan process with the running-mass definition for heavy quarks we show that fixed flavor number scheme is sufficient for describing the deep-inelastic-scattering data in the entire kinematic range. We compare with other PDF sets and comment on the implications for measuring the strong coupling constant {alpha}{sub s}(M{sub Z}).

  10. Repeat-PPM Super-Symbol Synchronization

    Science.gov (United States)

    Connelly, J.

    2016-11-01

    To attain a wider range of data rates in pulse position modulation (PPM) schemes with constrained pulse durations, the sender can repeat a PPM symbol multiple times, forming a super-symbol. In addition to the slot and symbol synchronization typically required for PPM, the receiver must also properly align the noisy super-symbols. We present a low-complexity approximation of the maximum-likelihood method for performing super-symbol synchronization without use of synchronization sequences. We provide simulation results demonstrating performance advantage when PPM symbols are spread by a pseudo-noise sequence, as opposed to simply repeating. Additionally, the results suggest that this super-symbol synchronization technique requires signal levels below those required for reliable communication. This validates that the PPM spreading approach proposed to CCSDS can work properly as part of the overall scheme.

  11. Axial Super-resolution Evanescent Wave Tomography

    CERN Document Server

    Pendharker, Sarang; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-01-01

    Optical tomographic reconstruction of a 3D nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography (AxSET) method that enables the use of regular evanescent wave microscopes like Total Internal Reflection Fluorescence Microscope (TIRF) beyond surface imaging, and achieve tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of three-dimensional fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by 1D (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axi...

  12. Mirror-enhanced super-resolution microscopy

    OpenAIRE

    2016-01-01

    Axial excitation confinement beyond the diffraction limit is crucial to the development of next-generation, super-resolution microscopy. STimulated Emission Depletion (STED) nanoscopy offers lateral super-resolution using a donut-beam depletion, but its axial resolution is still over 500 nm. Total internal reflection fluorescence microscopy is widely used for single-molecule localization, but its ability to detect molecules is limited to within the evanescent field of ~ 100 nm from the cell a...

  13. Correct self-assembling of spatial frequencies in super-resolution synthetic aperture digital holography.

    Science.gov (United States)

    Paturzo, Melania; Ferraro, Pietro

    2009-12-01

    Synthetic aperture enlargement is obtained, in lensless digital holography, by introducing a diffraction grating between the object and the CCD camera with the aim of getting super-resolution. We demonstrate here that the spatial frequencies are naturally self-assembled in the reconstructed image plane when the NA is increased synthetically at its maximum extent of three times. By this approach it possible to avoid the use of the grating transmission formula in the numerical reconstruction process, thus reducing significantly the noise in the final super-resolved image. Demonstrations are reported in 1D and 2D with an optical target and a biological sample, respectively.

  14. Generic super-exponential stability of elliptic equilibrium positions for symplectic vector fields

    Science.gov (United States)

    Niederman, Laurent

    2013-11-01

    In this article, we consider linearly stable elliptic fixed points (equilibrium) for a symplectic vector field and prove generic results of super-exponential stability for nearby solutions. We will focus on the neighborhood of elliptic fixed points but the case of linearly stable isotropic reducible invariant tori in a Hamiltonian system should be similar. More specifically, Morbidelli and Giorgilli have proved a result of stability over superexponentially long times if one considers an analytic Lagrangian torus, invariant for an analytic Hamiltonian system, with a diophantine translation vector which admits a sign-definite torsion. Then, the solutions of the system move very little over times which are super-exponentially long with respect to the inverse of the distance to the invariant torus. The proof proceeds in two steps: first one constructs a high-order Birkhoff normal form, then one applies the Nekhoroshev theory. Bounemoura has shown that the second step of this construction remains valid if the Birkhoff normal form linked to the invariant torus or the elliptic fixed point belongs to a generic set among the formal series. This is not sufficient to prove this kind of super-exponential stability results in a general setting. We should also establish that the most strongly non resonant elliptic fixed point or invariant torus in a Hamiltonian system admits Birkhoff normal forms fitted for the application of the Nekhoroshev theory. Actually, the set introduced by Bounemoura is already very large but not big enough to ensure that a typical Birkhoff normal form falls into this class. We show here that this property is satisfied generically in the sense of the measure (prevalence) through infinite-dimensional probe spaces (that is, an infinite number of parameters chosen at random) with methods similar to those developed in a paper of Gorodetski, Kaloshin and Hunt in another setting.

  15. Group-based single image super-resolution with online dictionary learning

    Science.gov (United States)

    Lu, Xuan; Wang, Dingwen; Shi, Wenxuan; Deng, Dexiang

    2016-12-01

    Recently, sparse representation has been successfully used in single image super-resolution reconstruction. Unlike the traditional single image super-resolution methods such as image interpolation, the super-resolution with sparse representation reconstructs image with one or several constant dictionaries learned from external databases. However, the contents can vary significantly across different patches in a single image, and the fixed dictionaries cannot suit for every patch. This paper presents a novel approach for single image super-resolution based on sparse representation, which uses group as the basic unit, and trains dictionary with external database and the input low-resolution image itself for each group to ensure that the dictionary is suitable for the patches in the group. Simultaneous sparse coding algorithm is used to accelerate the processing and improve the result. Extensive experiments on natural images show that our method achieves better results than some state-of-the-art algorithms in terms of both objective and human visual evaluations.

  16. SuperHILAC Upgrade Project

    Energy Technology Data Exchange (ETDEWEB)

    Feinberg, B.; Brown, I.G.

    1986-06-01

    A high current MEtal Vapor Vacuum Arc (MEVVA) ion source is to be installed in the third injector (Abel) at the SuperHILAC, representing the first accelerator use of this novel ion source. The MEVVA source has produced over 1 A of uranium in all charge states, with typically more than 100 electrical mA (emA) of U/sup 5 +/. A substantial fraction of this high current, heavy ion beam must be successfully transported to the entrance of the Wideroe linac to approach the 10 emA space-charge output limit of the Wideroe. Calculations show that up to 50 emA of U/sup 5 +/ can be transported through the present high voltage column. A bouncer will be added to the Cockcroft-Walton supply to handle the increased beam current. The Low Energy Beam Transport line vacuum will be improved to reduce charge exchange, and the phase matching between the 23 MHz Wideroe and the 70 MHz Alvarez linacs will be improved by the addition of two 70 HMz bunchers. The installation of the MEVVA source along with the modifications described above are expected to result in a five-fold increase in beam delivered to Bevatron experiments, increasing the extracted uranium beam to 5 x 10/sup 7/ ions/pulse.

  17. Super-B Project Overview

    Energy Technology Data Exchange (ETDEWEB)

    Biagini, M.E.; Boni, R.; Boscolo, M.; Demma, T.; Drago, A.; Guiducci, S.; Raimondi, P.; Tomassini, S.; Zobov, M.; /Frascati; Bertsche, K.; Donald, M.; Nosochkov, Y.; Novokhatski, A.; Seeman, J.; Sullivan, M.; Yocky, G.; Wienands, U.; Wittmer, W.; /SLAC; Koop, I.; Levichev, E.; Nikitin, S.; /Novosibirsk, IYF /KEK, Tsukuba /Pisa U. /CERN

    2010-08-26

    The SuperB project aims at the construction of an asymmetric very high luminosity B-Factory on the Frascati/Tor Vergata (Italy) area, providing a uniquely sensitive probe of New Physics in the flavour sector of the Standard Model. The luminosity goal of 10{sup 36} cm{sup -2} s{sup -1} can be reached with a new collision scheme with 'large Piwinski angle' (LPA) and the use of 'crab waist sextupoles' (CW). A LPA&CW Interaction Region (IR) has been successfully tested at the DA{Phi}NE {Phi}-Factory at LNF-Frascati in 2008. The LPA&CW scheme, together with very low {beta}*, will allow for operation with relatively low beam currents and reasonable bunch length, comparable to those of PEP-II and KEKB. In the High Energy Ring (HER), two spin rotators will bring longitudinally polarized beams into collision at the IP. The lattice has been designed with a very low intrinsic emittance and is quite compact, less than 2 km long. The tight focusing requires the final doublet quadrupoles to be very close to the IP and very compact. A Conceptual Design Report was published in March 2007, and beam dynamics and collective effects R&D studies are in progress in order to publish a Technical Design Report by the end of 2010.

  18. SUPER-B LATTICE STUDIES

    Energy Technology Data Exchange (ETDEWEB)

    Biagini, M.E.; Raimondi, P.; /Frascati; Piminov, P.; Sinyatkin, S.; /Novosibirsk, IYF; Nosochkov, Y.; Wittmer, W.; /SLAC

    2010-08-25

    The SuperB asymmetric e{sup +}e{sup -} collider is designed for 10{sup 36} cm{sup -2} s{sup -1} luminosity and beam energies of 6.7 and 4.18 GeV for e{sup +} and e{sup -} respectively. The High and Low Energy Rings (HER and LER) have one Interaction Point (IP) with 66 mrad crossing angle. The 1258 m rings fit to the INFN-LNF site at Frascati. The ring emittance is minimized for the high luminosity. The Final Focus (FF) chromaticity correction is optimized for maximum transverse acceptance and energy bandwidth. Included Crab Waist sextupoles suppress betatron resonances induced in the collisions with a large Piwinski angle. The LER Spin Rotator sections provide longitudinally polarized electron beam at the IP. The lattice is flexible for tuning the machine parameters and compatible with reusing the PEP-II magnets, RF cavities and other components. Details of the lattice design are presented.

  19. Studies of the Super VELO

    CERN Document Server

    AUTHOR|(CDS)2156302

    2016-01-01

    The Super VELO is the Run 5 upgrade of the VeloPix detector of the LHCb experiment. Its most challenging task is to cope with a luminosity increase of the factor 10. This study examines the potential physics performance of a detector based on the VeloPix design at high luminosity conditions. It is found that an unmodified VeloPix detector shows poor performance when exposed to 10x design luminosity, most gravely high ghost rates of 40 %. When applying basic assumptions about material changes such as cutting the silicon thickness by half and removing the RF foil, the ghost rate drops by 20 %. When using thin silicon and re-optimizing the tracking algorithm, the ghost rate can even be reduced by 60 %. Applying the additional modification of a pixel area size four times smaller, the ghost rate drops by 88 % and the IP resolution improves. Finally, in a dream scenario with thin silicon, smaller pixels and no RF foil, big gains in resolution and a ghost rate of less than 4 % can be achieved.

  20. N-terminal processing of membrane-targeted MnSOD and formation of multiple active superoxide dismutase dimers in the nitrogen-fixing cyanobacterium Anabaena sp. strain PCC7120.

    Science.gov (United States)

    Raghavan, Prashanth S; Rajaram, Hema; Apte, Shree K

    2013-10-01

    Anabaena sp. strain PCC7120 expresses a 30 kDa manganese-dependent superoxide dismutase (MnSOD) comprising a hydrophobic region (signal peptide + linker peptide) attached to a catalytic unit. Bioinformatics predicted cleavage of the signal peptide at (25)CQPQ by signal peptidase and of the linker peptide by an Arg-C-like protease at the Arg52/Arg59 residue. The three predicted forms of MnSOD were immunodetected in Anabaena, with the 30 kDa MnSOD found exclusively in the membrane and the shorter 27 and 24 kDa forms found both in the membrane and soluble fractions. The corresponding sodA gene was truncated for (a) the first eight residues, or, (b) the signal peptide, or (c) the entire hydrophobic region, or (d) the Arg52/Arg59 residues were modified to serine. Overexpression of these MnSOD variants in recombinant Anabaena strains revealed that (a) the 30 kDa membrane-targeted MnSOD was cleaved by membrane-localized signal peptidase either during or after its transport through the membrane to release the 27 kDa form, either in the cytosol or in the periplasmic/thylakoid lumen, (b) the 27 kDa form was further cleaved to the 24 kDa form by Arg-C-like protease, both in the cytosol and in the periplasmic/thylakoid lumen, (c) deletion of signal peptide localized the MnSOD forms in the cytosol, and (d) alteration of the signal/linker peptide cleavage sites interfered with MnSOD localization and processing. Homo/heterodimerization of the 24 and 27 kDa forms of MnSOD and the cytosolic iron-dependent SOD results in multiple SOD activities, from a single MnSOD gene (sodA), in different cellular compartments of Anabaena.

  1. Modified super twisting controller for servicing to uncontrolled spacecraft

    Institute of Scientific and Technical Information of China (English)

    Binglong Chen; Yunhai Geng

    2015-01-01

    A relative position and attitude coupled sliding mode control er is proposed by combining the standard super twisting (ST) control and basic linear algorithm for autonomous rendezvous and docking. It is schemed for on-orbit servicing to a tumbling non-cooperative target spacecraft subjected to external disturbances. A coupled dynamic model is established including both kinemati-cal and dynamic coupled effect of relative rotation on relative translation, which il ustrates the relative movement between the docking port located in target spacecraft and another in service spacecraft. The modified super twisting (MST) control algorithm containing linear compensation items is schemed to manipulate the relative position and attitude synchronously. The correction provides more robustness and convergence velocity for dealing with linearly growing perturbations than the ST control algorithm. Moreover, the stability characteristic of closed-loop system is ana-lyzed by Lyapunov method. Numerical simulations are adopted to verify the analysis with the comparison between MST and ST control algorithms. Simulation results demonstrate that the pro-posed MST control er is characterized by high precision, strong robustness and fast convergence velocity to attenuate the linearly increasing perturbations.

  2. A novel approach to the island of stability of super-heavy elements search

    Directory of Open Access Journals (Sweden)

    Wieloch A.

    2016-01-01

    Full Text Available It is expected that the cross section for super-heavy nuclei production of Z > 118 is dropping into the region of tens of femto barns. This creates a serious limitation for the complete fusion technique that is used so far. Moreover, the available combinations of the neutron to proton ratio of stable projectiles and targets are quite limited and it can be difficult to reach the island of stability of super heavy elements using complete fusion reactions with stable projectiles. In this context, a new experimental investigation of mechanisms other than complete fusion of heavy nuclei and a novel experimental technique are invented for our search of super- and hyper-nuclei. This contribution is focused on that technique.

  3. Simultaneous measurements of super-radiance at multiple wavelengths from helium excited states: (I) Experiment

    CERN Document Server

    Nakajima, Kyo; Iwayama, Hiroshi; Kuma, Susumu; Miyamoto, Yuki; Nagasono, Mitsuru; Ohae, Chiaki; Togashi, Tadashi; Yabashi, Makina; Shigemasa, Eiji; Sasao, Noboru

    2014-01-01

    In this paper, we report the results of measurements of the intensities and delays of super-radiance decays from excited helium atoms at multiple wavelengths. The experiment was performed using extreme ultraviolet radiation produced by the free electron laser at the SPring-8 Compact SASE Source test accelerator facility as an excitation source. We observed super-radiant transitions on the $1s3p \\to 1s2s$ ($\\lambda=$502 nm), $1s3d \\to 1s2p$ ($\\lambda=$668 nm), and $1s3s \\to 1s2p$ ($\\lambda=$728 nm) transitions. The pulse energy of each transition and its delay time were measured as a function of the target helium gas density. Several interesting features of the data, some of which appear to contradict with the predictions of the simple two-level super-radiance theory, are pointed out.

  4. Multi-pulse pumping for far-field super-resolution imaging

    Science.gov (United States)

    Requena, Sebastian; Raut, Sangram; Doan, Hung; Kimball, Joe; Fudala, Rafal; Borejdo, Julian; Gryczynski, Ignacy; Strzhemechny, Yuri; Gryczynski, Zygmunt

    2016-02-01

    Recently, far-field optical imaging with a resolution significantly beyond diffraction limit has attracted tremendous attention allowing for high resolution imaging in living objects. Various methods have been proposed that are divided in to two basic approaches; deterministic super-resolution like STED or RESOLFT and stochastic super-resolution like PALM or STORM. We propose to achieve super-resolution in far-field fluorescence imaging by the use of controllable (on-demand) bursts of pulses that can change the fluorescence signal of long-lived component over one order of magnitude. We demonstrate that two beads, one labeled with a long-lived dye and another with a short-lived dye, separated by a distance lower than 100 nm can be easily resolved in a single experiment. The proposed method can be used to separate two biological structures in a cell by targeting them with two antibodies labeled with long-lived and short-lived fluorophores.

  5. APES-based procedure for super-resolution SAR imagery with GPU parallel computing

    Science.gov (United States)

    Jia, Weiwei; Xu, Xiaojian; Xu, Guangyao

    2015-10-01

    The amplitude and phase estimation (APES) algorithm is widely used in modern spectral analysis. Compared with conventional Fourier transform (FFT), APES results in lower sidelobes and narrower spectral peaks. However, in synthetic aperture radar (SAR) imaging with large scene, without parallel computation, it is difficult to apply APES directly to super-resolution radar image processing due to its great amount of calculation. In this paper, a procedure is proposed to achieve target extraction and parallel computing of APES for super-resolution SAR imaging. Numerical experimental are carried out on Tesla K40C with 745 MHz GPU clock rate and 2880 CUDA cores. Results of SAR image with GPU parallel computing show that the parallel APES is remarkably more efficient than that of CPU-based with the same super-resolution.

  6. National Radiological Fixed Lab Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — The National Radiological Fixed Laboratory Data Asset includes data produced in support of various clients such as other EPA offices, EPA Regional programs, DOE,...

  7. Elevated Fixed Platform Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Elevated Fixed Platform (EFP) is a helicopter recovery test facility located at Lakehurst, NJ. It consists of a 60 by 85 foot steel and concrete deck built atop...

  8. Fixed Exchange Rates and Trade

    OpenAIRE

    Michael W. Klein; Jay C. Shambaugh

    2004-01-01

    A classic argument for a fixed exchange rate is its promotion of trade. Empirical support for this, however, is mixed. While one branch of research consistently shows a small negative effect of exchange rate volatility on trade, another, more recent, branch presents evidence of a large positive impact of currency unions on trade. This paper helps resolve this disconnect. Our results, which use a new data-based classification of fixed exchange rate regimes, show a large, significant effect of ...

  9. Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions

    CERN Document Server

    Deschout, Hendrik; Sharipov, Azat; Szlag, Daniel; Feletti, Lely; Vandenberg, Wim; Dedecker, Peter; Hofkens, Johan; Leutenegger, Marcel; Lasser, Theo; Radenovic, Aleksandra

    2016-01-01

    Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy. We have addressed this important issue by combining photo-activated localization microscopy (PALM) with super-resolution optical fluctuation imaging (SOFI). Using simulations and fixed cell focal adhesion images, we investigated the complementarity between PALM and SOFI in terms of spatial and temporal resolution. This PALM-SOFI framework was used to image focal adhesions in living cells, while obtaining a temporal resolution below 10 s. We visualized the dynamics of focal adhesions, and revealed local mean velocities around 190 nm per minute. The complementarity of PALM and SOFI was assessed in detail with a methodology that integrates a quantitative resolution and signal-to-noise metric. This PALM and SOFI concept provides an enlarged quantitative imaging framework, allowing unprecedented functional exploration of focal adhesions through the estimation of m...

  10. Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

    Science.gov (United States)

    Deschout, Hendrik; Lukes, Tomas; Sharipov, Azat; Szlag, Daniel; Feletti, Lely; Vandenberg, Wim; Dedecker, Peter; Hofkens, Johan; Leutenegger, Marcel; Lasser, Theo; Radenovic, Aleksandra

    2016-12-01

    Live-cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenge for super-resolution microscopy. Here we address this important issue by combining photoactivated localization microscopy (PALM) with super-resolution optical fluctuation imaging (SOFI). Using simulations and fixed-cell focal adhesion images, we investigate the complementarity between PALM and SOFI in terms of spatial and temporal resolution. This PALM-SOFI framework is used to image focal adhesions in living cells, while obtaining a temporal resolution below 10 s. We visualize the dynamics of focal adhesions, and reveal local mean velocities around 190 nm min-1. The complementarity of PALM and SOFI is assessed in detail with a methodology that integrates a resolution and signal-to-noise metric. This PALM and SOFI concept provides an enlarged quantitative imaging framework, allowing unprecedented functional exploration of focal adhesions through the estimation of molecular parameters such as fluorophore densities and photoactivation or photoswitching kinetics.

  11. High contrast imaging of exoplanets on ELTs using a super-Nyquist wavefront control scheme

    CERN Document Server

    Gerard, Benjamin L

    2016-01-01

    One of the key science goals for extremely large telescopes (ELTs) is the detailed characterization of already known directly imaged exoplanets. The typical adaptive optics (AO) Nyquist control region for ELTs is ~0.4 arcseconds, placing many already known directly imaged planets outside the DM control region and not allowing any standard wavefront control scheme to remove speckles that would allow higher SNR images/spectra to be acquired. This can be fixed with super-Nyquist wavefront control (SNWFC), using a sine wave phase plate to allow for wavefront control outside the central DM Nyquist region. We demonstrate that SNWFC is feasible through a simple, deterministic, non-coronagraphic, super-Nyquist speckle nulling technique in the adaptive optics laboratory at the National Research Council of Canada. We also present results in simulation of how SNWFC using the self coherent camera (SCC) can be used for high contrast imaging. This technique could be implemented on future high contrast imaging instruments t...

  12. On Super (a,d-Edge-Antimagic Total Labeling of Special Types of Crown Graphs

    Directory of Open Access Journals (Sweden)

    Himayat Ullah

    2013-01-01

    Full Text Available For a graph G=(V,E, a bijection f from V(G∪E(G→{1,2,…,|V(G|+|E(G|} is called (a,d-edge-antimagic total ((a,d-EAT labeling of G if the edge-weights w(xy=f(x+f(y+f(xy,xy∈E(G, form an arithmetic progression starting from a and having a common difference d, where a>0 and d≥0 are two fixed integers. An (a,d-EAT labeling is called super (a,d-EAT labeling if the vertices are labeled with the smallest possible numbers; that is, f(V={1,2,…,|V(G|}. In this paper, we study super (a,d-EAT labeling of cycles with some pendant edges attached to different vertices of the cycle.

  13. Axial super-resolution evanescent wave tomography.

    Science.gov (United States)

    Pendharker, Sarang; Shende, Swapnali; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-12-01

    Optical tomographic reconstruction of a three-dimensional (3D) nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography method that enables the use of regular evanescent wave microscopes like the total internal reflection fluorescence microscope beyond surface imaging and achieve a tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of 3D fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by one-dimensional (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axial resolution of ∼130  nm. Our method does not require any additional optical components or sample preparation. The proposed method can be combined with focal plane super-resolution techniques like stochastic optical reconstruction microscopy and can also be adapted for THz and microwave near-field tomography.

  14. Axial super-resolution evanescent wave tomography

    Science.gov (United States)

    Pendharker, Sarang; Shende, Swapnali; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-12-01

    Optical tomographic reconstruction of a 3D nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography (AxSET) method that enables the use of regular evanescent wave microscopes like Total Internal Reflection Fluorescence Microscope (TIRF) beyond surface imaging, and achieve tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of three-dimensional fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by 1D (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axial resolution of $\\sim$130 nm. Our method does not require any additional optical components or sample preparation. The proposed method can be combined with focal plane super-resolution techniques like STORM and can also be adapted for THz and microwave near-field tomography.

  15. A Comparison Simulation of Fixed-fixed Type MEMS Switches

    Science.gov (United States)

    Rezazadeh, G.; Sadeghian, H.; Malekpour, E.

    2006-04-01

    In the present work pull-in voltage of fixed-fixed end type MEMS switches with variative electrostatic area has been calculated using a distributed model and applying a full nonlinear finite difference discretizing method. The governing nonlinear differential equation has been derived using of the variational principle for multi domain electromechanical coupled system. The numerical results of the beam with variative electrostatic area with the results of Coupled-Domain Finite Element method have been compared and very good agreement has been achieved.

  16. Diclofenac Induced Fixed Drug Eruption

    Directory of Open Access Journals (Sweden)

    Dr. Umeshchandra C Honnaddi

    2016-02-01

    Full Text Available Background: Diclofenac is the most commonly used non-steroidal anti-inflammatory drug (NSAID for treating various inflammatory and painful conditions. It is generally well tolerated; gastric upset is the most common adverse effect. However very few cases of fixed drug eruptions were reported. Here we present a case of Diclofenac Induced Fixed Drug Eruption. A 62 year old male patient developed fixed drug eruptions with plaques on left thigh two days after receiving diclofenac for osteoarthritic pain. Other etiologies including insect bite, infections were ruled out. One week later after stopping the drug, the lesions were subsided. Diclofenac was strongly suspected as the casual drug. CD8+ effector T-cells have shown to play an important role. However it seems to be a reversible and drug related event. Although it is not life-threatening, fixed drug eruption can have significant effect on the quality of life of patients.Conclusion: Diclofenac is one of the most commonly prescribed NSAIDs by the Physicians. It is usually well tolerated, gastric upset is the most common adverse effect noted with this drug. This case is being reported to highlight a drug as safe as Diclofenac may also be associated with Fixed Drug Eruptions.

  17. Assessing resolution in super-resolution imaging.

    Science.gov (United States)

    Demmerle, Justin; Wegel, Eva; Schermelleh, Lothar; Dobbie, Ian M

    2015-10-15

    Resolution is a central concept in all imaging fields, and particularly in optical microscopy, but it can be easily misinterpreted. The mathematical definition of optical resolution was codified by Abbe, and practically defined by the Rayleigh Criterion in the late 19th century. The limit of conventional resolution was also achieved in this period, and it was thought that fundamental constraints of physics prevented further increases in resolution. With the recent development of a range of super-resolution techniques, it is necessary to revisit the concept of optical resolution. Fundamental differences in super-resolution modalities mean that resolution is not a directly transferrable metric between techniques. This article considers the issues in resolution raised by these new technologies, and presents approaches for comparing resolution between different super-resolution methods.

  18. Architectural Engineering to Super-Light Structures

    DEFF Research Database (Denmark)

    Castberg, Niels Andreas

    with architectural engineering as a starting point. The thesis is based on a two stringed hypothesis: Architectural engineering gives rise to better architecture and Super-Light Structures support and enables a static, challenging architecture. The aim of the thesis is to clarify architectural engineering's impact...... on the work process between architects and engineers in the design development. Using architectural engineering, Super-Light Structures are examined in an architectural context, and it is explained how digital tools can support architectural engineering and design of Super-Light Structures. The experiences...... to be subjects of examination for this thesis. The research results show that architectural engineering has a significant impact on a design process. The projects illustrate that simple explanations, underpinned by visualisations of the challenges between shape versus structure, often creates a shared...

  19. Breeding Super-Earths and Birthing Super-Puffs in Transitional Disks

    CERN Document Server

    Lee, Eve J

    2015-01-01

    The riddle posed by super-Earths (1-4$R_\\oplus$, 2-20$M_\\oplus$) is that they are not Jupiters: their core masses are large enough to trigger runaway gas accretion, yet somehow super-Earths accreted atmospheres that weigh only a few percent of their total mass. We show that this puzzle is solved if super-Earths formed late, as the last vestiges of their parent gas disks were about to clear. This scenario would seem to present fine-tuning problems, but we show that there are none. Ambient gas densities can span many (up to 9) orders of magnitude, and super-Earths can still robustly emerge after $\\sim$0.1-1 Myr with percent-by-weight atmospheres. Super-Earth cores are naturally bred in gas-poor environments where gas dynamical friction has weakened sufficiently to allow constituent protocores to merge. So little gas is present at the time of core assembly that cores hardly migrate by disk torques: formation of super-Earths can be in situ. The picture --- that close-in super-Earths form in a gas-poor (but not ga...

  20. Evidence of the Big Fix

    CERN Document Server

    Hamada, Yuta; Kawana, Kiyoharu

    2014-01-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value $v_{h}$. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self coupling are fixed when we vary $v_{h}$. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental low in our case.

  1. Evidence of the big fix

    Science.gov (United States)

    Hamada, Yuta; Kawai, Hikaru; Kawana, Kiyoharu

    2014-06-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value vh. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self-coupling are fixed when we vary vh. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental law in our case.

  2. KML Super Overlay to WMS Translator

    Science.gov (United States)

    Plesea, Lucian

    2007-01-01

    This translator is a server-based application that automatically generates KML super overlay configuration files required by Google Earth for map data access via the Open Geospatial Consortium WMS (Web Map Service) standard. The translator uses a set of URL parameters that mirror the WMS parameters as much as possible, and it also can generate a super overlay subdivision of any given area that is only loaded when needed, enabling very large areas of coverage at very high resolutions. It can make almost any dataset available as a WMS service visible and usable in any KML application, without the need to reformat the data.

  3. Super-resolution optical microscopy: multiple choices.

    Science.gov (United States)

    Huang, Bo

    2010-02-01

    The recent invention of super-resolution optical microscopy enables the visualization of fine features in biological samples with unprecedented clarity. It creates numerous opportunities in biology because vast amount of previously obscured subcellular processes now can be directly observed. Rapid development in this field in the past two years offers many imaging modalities that address different needs but they also complicates the choice of the 'perfect' method for answering a specific question. Here I will briefly describe the principles of super-resolution optical microscopy techniques and then focus on comparing their characteristics in various aspects of practical applications.

  4. Super resolution of images and video

    CERN Document Server

    Katsaggelos, Aggelos K

    2007-01-01

    This book focuses on the super resolution of images and video. The authors' use of the term super resolution (SR) is used to describe the process of obtaining a high resolution (HR) image, or a sequence of HR images, from a set of low resolution (LR) observations. This process has also been referred to in the literature as resolution enhancement (RE). SR has been applied primarily to spatial and temporal RE, but also to hyperspectral image enhancement. This book concentrates on motion based spatial RE, although the authors also describe motion free and hyperspectral image SR problems. Also exa

  5. Super-Laplacians and their symmetries

    Science.gov (United States)

    Howe, P. S.; Lindström, U.

    2017-05-01

    A super-Laplacian is a set of differential operators in superspace whose highestdimensional component is given by the spacetime Laplacian. Symmetries of super-Laplacians are given by linear differential operators of arbitrary finite degree and are determined by superconformal Killing tensors. We investigate these in flat superspaces. The differential operators determining the symmetries give rise to algebras which can be identified in many cases with the tensor algebras of the relevant superconformal Lie algebras modulo certain ideals. They have applications to Higher Spin theories.

  6. Professor Claude Detraz, Director for fixed target and future programmes

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Four of them came under the newly established collaboration agreement between CERN (Prof. Claude Detraz) and NTU (Prof. Evangelos Gazis), prepared by Dr. Magda Lola (CERN-Recruitment Service), for the training of students at the Laboratory, while two more are participants to the standard CERN Summer Students Programme.

  7. Workshop on the AGS fixed-target research program

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, L; Schewe, P; Wanderer, P; Weisberg, H [eds.

    1978-01-01

    The summarized results of a two day workshop to determine experiment programs for the Brookhaven AGS during the construction period of the ISABELLE storage rings and after are presented. Topics covered include: experiments with low-energy beams; experiments with higher energy beams; neutrino physics; and polarized protons. (GHT)

  8. An atmosphere around the super-Earth 55 Cancri e

    Science.gov (United States)

    Tsiaras, Angelos; Rocchetto, Marco; Waldmann, Ingo; Venot, Olivia; Varley, Rayan; Morello, Giuseppe; Damiano, Mario; Tinetti, Giovanna; Barton, Emma; Yurchenko, Sergey; Tennyson, Jonathan; ExoLights, ExoMol

    2016-10-01

    One of the most successful instruments for observing exoplanetary atmospheres is the Wide Field Camera 3 (WFC3) onboard the Hubble Space Telescope (HST). In particular, the use of the spatial scanning technique has given us the opportunity for even more efficient observations of the brightest targets, achieving the necessary precision of 10 – 100 ppm. With such data and new advanced reduction and statistical techniques, we were able to detect modulations in the spectrum of the hot super-Earth 55 Cancri e, which suggest the existence of a light-weight atmosphere around this planet. Given the brightness of 55 Cancri, the observers adopted a very long scanning length and a very high scanning speed. We took these effects into account, as they can introduce systematics when coupled with the geometrical distortions of the instrument. Our fully Bayesian spectral retrieval code, T-REx, has identified HCN to be the most likely molecular candidate able to explain the features at 1.42 and 1.54 μm. While additional spectroscopic observations in a broader wavelength range in the infrared will be needed to confirm the HCN detection, we used a chemical model, developed with combustion specialists, to explain its pressence. This model indicates that relatively high mixing ratios of HCN may be caused by a high C/O ratio, suggesting this super-Earth is a carbon-rich environment even more exotic than previously thought.

  9. Super Natural II--a database of natural products.

    Science.gov (United States)

    Banerjee, Priyanka; Erehman, Jevgeni; Gohlke, Björn-Oliver; Wilhelm, Thomas; Preissner, Robert; Dunkel, Mathias

    2015-01-01

    Natural products play a significant role in drug discovery and development. Many topological pharmacophore patterns are common between natural products and commercial drugs. A better understanding of the specific physicochemical and structural features of natural products is important for corresponding drug development. Several encyclopedias of natural compounds have been composed, but the information remains scattered or not freely available. The first version of the Supernatural database containing ∼ 50,000 compounds was published in 2006 to face these challenges. Here we present a new, updated and expanded version of natural product database, Super Natural II (http://bioinformatics.charite.de/supernatural), comprising ∼ 326,000 molecules. It provides all corresponding 2D structures, the most important structural and physicochemical properties, the predicted toxicity class for ∼ 170,000 compounds and the vendor information for the vast majority of compounds. The new version allows a template-based search for similar compounds as well as a search for compound names, vendors, specific physical properties or any substructures. Super Natural II also provides information about the pathways associated with synthesis and degradation of the natural products, as well as their mechanism of action with respect to structurally similar drugs and their target proteins.

  10. New method for making super-plastic glasses

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ It was a long-cherished dream for materials scientists to find a nearly ideal metallic alloy with high strength and super-plasticity concurrently as a super-material both extremely strong and exceptionally hard for human use.

  11. Second invariant for two-dimensional classical super systems

    Indian Academy of Sciences (India)

    S C Mishra; Roshan Lal; Veena Mishra

    2003-10-01

    Construction of superpotentials for two-dimensional classical super systems (for ≥ 2) is carried out. Some interesting potentials have been studied in their super form and also their integrability.

  12. Fixed-point signal processing

    CERN Document Server

    Padgett, Wayne T

    2009-01-01

    This book is intended to fill the gap between the ""ideal precision"" digital signal processing (DSP) that is widely taught, and the limited precision implementation skills that are commonly required in fixed-point processors and field programmable gate arrays (FPGAs). These skills are often neglected at the university level, particularly for undergraduates. We have attempted to create a resource both for a DSP elective course and for the practicing engineer with a need to understand fixed-point implementation. Although we assume a background in DSP, Chapter 2 contains a review of basic theory

  13. Perfect and Imperfect Gauge Fixing

    CERN Document Server

    Shirzad, A

    2006-01-01

    Gauge fixing may be done in different ways. We show that using the chain structure to describe a constrained system, enables us to use either a perfect gauge, in which all gauged degrees of freedom are determined; or an imperfect gauge, in which some first class constraints remain as subsidiary conditions to be imposed on the solutions of the equations of motion. We also show that the number of constants of motion depends on the level in a constraint chain in which the gauge fixing condition is imposed. The relativistic point particle, electromagnetism and the Polyakov string are discussed as examples and perfect or imperfect gauges are distinguished.

  14. Fixed effects analysis of variance

    CERN Document Server

    Fisher, Lloyd; Birnbaum, Z W; Lukacs, E

    1978-01-01

    Fixed Effects Analysis of Variance covers the mathematical theory of the fixed effects analysis of variance. The book discusses the theoretical ideas and some applications of the analysis of variance. The text then describes topics such as the t-test; two-sample t-test; the k-sample comparison of means (one-way analysis of variance); the balanced two-way factorial design without interaction; estimation and factorial designs; and the Latin square. Confidence sets, simultaneous confidence intervals, and multiple comparisons; orthogonal and nonorthologonal designs; and multiple regression analysi

  15. An integrable generalization of the super AKNS hierarchy and its bi-Hamiltonian formulation

    Science.gov (United States)

    Yu, Jing; Ma, Wen-Xiu; Han, Jingwei; Chen, Shouting

    2017-02-01

    Based on a Lie super-algebra B(0, 1), an integrable generalization of the super AKNS iso-spectral problem is introduced and its corresponding generalized super AKNS hierarchy is generated. By making use of the super-trace identity (or the super variational identity), the resulting super soliton hierarchy can be put into a super bi-Hamiltonian form. A generalized super AKNS soliton hierarchy with self-consistent sources is also presented.

  16. Explosive Super-eruptions: Problems and Prejudices

    Science.gov (United States)

    Self, S.

    2010-12-01

    A super-eruption is defined as one with a magma yield > 10^15 kg (magnitude (M) 8). The term has mainly been applied to large-scale, caldera and ignimbrite-forming explosive eruptions, but it can be applied to all eruptions that released > 10^15 kg of magma. For effusive volcanism, evidence suggests that individual eruptions of this size ( > ~ 370 km^3 of typical basalt or > 450 km^3 of rhyolite flood lava) arise only during periods of LIP formation. The super-eruption concept raises interesting questions about genesis and storage of magmas that feed these vast events. Deposits of major explosive eruptions are Plinian fallout, ignimbrite sheets, and co-ignimbrite ash fall. Based on earlier suggestions and evidence, widespread outflow ignimbrite (O), co-ignimbrite ash (A), and inter-caldera ignimbrite (I) are all major components of the total super-eruption deposit and may tend towards being subequal. In super-eruption deposits, the reported volume of vent-derived Plinian eruption column fallout is often a minor component of the total volume, yet in several cases (Oruanui, Taupo, 26 ka ago, M 8.1; Bishop Tuff, 760 ka, M 8.2; Bandelier (Otowi) Tuff, 1.6 Ma, M8) it is now recognized that vent-derived columns persisted for most of the eruption. Thus, distally, the ash-fall derived from co-ignimbrite ash clouds may be mixed with contemporaneous fallout from a vertical column. Some major ignimbrites have no reported associated Plinian deposit; the huge Young Toba Tuff (YTT, 74 ka, M 8.8) is a significant example. However, the very widespread Toba ash-fall deposit constitutes ~ 40 % of the total mass of magma erupted and is presumed to be co-ignimbrite. Timing of the onset of column collapse probably controls whether a recognizable Plinian deposit is laid down. All super-eruptions probably produce extensive fallout deposits, and this is generally of vent-derived and pyroclastic-flow-derived origin. Establishing the relationships between large-scale ignimbrites and their

  17. On super edge-graceful trees of diameter four

    CERN Document Server

    Krop, E; Raridan, C

    2011-01-01

    In "On the super edge graceful trees of even orders," Chung, Lee, Gao, and Schaffer posed the following problem: Characterize trees of diameter 4 which are super edge-graceful. In this paper, we provide super edge-graceful labelings for all caterpillars and even size lobsters of diameter 4 which permit such labelings. We also provide super edge-graceful labelings for several families of odd size lobsters of diameter 4.

  18. A Fast Measurement based fixed-point Quantum Search Algorithm

    CERN Document Server

    Mani, Ashish

    2011-01-01

    Generic quantum search algorithm searches for target entity in an unsorted database by repeatedly applying canonical Grover's quantum rotation transform to reach near the vicinity of the target entity represented by a basis state in the Hilbert space associated with the qubits. Thus, when qubits are measured, there is a high probability of finding the target entity. However, the number of times quantum rotation transform is to be applied for reaching near the vicinity of the target is a function of the number of target entities present in the unsorted database, which is generally unknown. A wrong estimate of the number of target entities can lead to overshooting or undershooting the targets, thus reducing the success probability. Some proposals have been made to overcome this limitation. These proposals either employ quantum counting to estimate the number of solutions or fixed point schemes. This paper proposes a new scheme for stopping the application of quantum rotation transformation on reaching near the ...

  19. Adaptive uniform finite-/fixed-time convergent second-order sliding-mode control

    Science.gov (United States)

    Basin, Michael; Bharath Panathula, Chandrasekhara; Shtessel, Yuri

    2016-09-01

    This paper presents an adaptive gain algorithm for second-order sliding-mode control (2-SMC), specifically a super-twisting (STW)-like controller, with uniform finite/fixed convergence time, that is robust to perturbations with unknown bounds. It is shown that a second-order sliding mode is established as exact finite-time convergence to the origin if the adaptive gain does not have the ability to get reduced and converge to a small vicinity of the origin if the adaptation algorithm does not overestimate the control gain. The estimate of fixed convergence time of the studied adaptive STW-like controller is derived based on the Lyapunov analysis. The efficacy of the proposed adaptive algorithm is illustrated in a tutorial example, where the adaptive STW-like controller with uniform finite/fixed convergence time is compared to the adaptive STW controller with non-uniform finite convergence time.

  20. The relationship between mean birth weight and poverty using the Townsend deprivation score and the Super Profile classification system.

    Science.gov (United States)

    Aveyard, P; Manaseki, S; Chambers, J

    2002-11-01

    Super Profiles have been used as alternative methods of characterising the deprivation of an area. Some reports suggest that Super Profiles are as accurate as established indices such as the Townsend score (TS). This was a test of this assertion.A total of 138 696 live born singleton births to Birmingham residents born between 1986 and 1996 (inclusive) were allocated to enumeration districts (EDs) by linkage from the postcode. We allocated the TS of the individual's ED. We allocated a Lifestyle and Target Market (TM) from Super Profiles by linkage to the ED. We examined the gradient between mean birth weight and the 10 Super Profile Lifestyles and compared this to the gradient between 10 Townsend groups and mean birth weight. We repeated this approach using the 40 TMs and 40 Townsend groups. We used both the median income and a census-derived deprivation measure to rank Lifestyles and TMs. The gradient between mean birth weight and area deprivation was linear for Townsend groups but not linear using either Lifestyles or TMs whichever method of ranking Lifestyles or TMs was used. Where Lifestyles or TMs were out of line with their neighbours, the TS of that group mostly explained this. As Super Profiles are generated using nationally representative data, applying the affluence ranking to small areas can lead to inaccuracies, as shown in this data. We conclude that Super Profiles are probably unsuitable as measures of deprivation of small areas.

  1. The structure of the super-W∞(λ) algebra

    NARCIS (Netherlands)

    Bergshoeff, E.; Wit, B. de; Vasiliev, M.

    1991-01-01

    We give a comprehensive treatment of the super-W∞(λ) algebra, an extension of the super-Virasoro algebra that contains generators of spin s ≥ ½. The parameter λ defines the embedding of the Virasoro subalgebra. We describe how to obtain the super-W∞(λ) algebra from the associative algebra of

  2. Flat coalgebraic fixed point logics

    CERN Document Server

    Schröder, Lutz

    2010-01-01

    Fixed point logics have a wide range of applications in computer science, in particular in artificial intelligence and concurrency. The most expressive logics of this type are the mu-calculus and its relatives. However, popular fixed point logics tend to trade expressivity for simplicity and readability, and in fact often live within the single variable fragment of the mu-calculus. The family of such flat fixed point logics includes, e.g., CTL, the *-nesting-free fragment of PDL, and the logic of common knowledge. Here, we extend this notion to the generic semantic framework of coalgebraic logic, thus covering a wide range of logics beyond the standard mu-calculus including, e.g., flat fragments of the graded mu-calculus and the alternating-time mu-calculus (such as ATL), as well as probabilistic and monotone fixed point logics. Our main results are completeness of the Kozen-Park axiomatization and a timed-out tableaux method that matches EXPTIME upper bounds inherited from the coalgebraic mu-calculus but avo...

  3. Landau Gauge Fixing on GPUs

    CERN Document Server

    Cardoso, Nuno; Bicudo, Pedro; Oliveira, Orlando

    2012-01-01

    In this paper we present and explore the performance of Landau gauge fixing in GPUs using CUDA. We consider the steepest descent algorithm with Fourier acceleration, and compare the GPU performance with a parallel CPU implementation. Using $32^4$ lattice volumes, we find that the computational power of a single Tesla C2070 GPU is equivalent to approximately 256 CPU cores.

  4. Fixed drug eruption to tartrazine.

    Science.gov (United States)

    Orchard, D C; Varigos, G A

    1997-11-01

    An 11-year-old girl with a recurrent fixed drug eruption to tartrazine on the dorsum of the left hand is presented. Oral provocation tests to both the suspected food, an artificially coloured cheese crisp, and to tartrazine were positive. This case highlights fire need to consider artificial flavours, colours and preservatives as potential culprits in classic drug eruptions.

  5. Adhesives for fixed orthodontic bands.

    Science.gov (United States)

    Millett, Declan T; Glenny, Anne-Marie; Mattick, Rye Cr; Hickman, Joy; Mandall, Nicky A

    2016-10-25

    Orthodontic treatment involves using fixed or removable appliances (dental braces) to correct the positions of teeth. It has been shown that the quality of treatment result obtained with fixed appliances is much better than with removable appliances. Fixed appliances are, therefore, favoured by most orthodontists for treatment. The success of a fixed orthodontic appliance depends on the metal attachments (brackets and bands) being attached securely to the teeth so that they do not become loose during treatment. Brackets are usually attached to the front and side teeth, whereas bands (metal rings that go round the teeth) are more commonly used on the back teeth (molars). A number of adhesives are available to attach bands to teeth and it is important to understand which group of adhesives bond most reliably, as well as reducing or preventing dental decay during the treatment period. To evaluate the effectiveness of the adhesives used to attach bands to teeth during fixed appliance treatment, in terms of:(1) how often the bands come off during treatment; and(2) whether they protect the banded teeth against decay during fixed appliance treatment. The following electronic databases were searched: Cochrane Oral Health's Trials Register (searched 2 June 2016), Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 5) in the Cochrane Library (searched 2 June 2016), MEDLINE Ovid (1946 to 2 June 2016) and EMBASE Ovid (1980 to 2 June 2016). We searched ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases. Randomised and controlled clinical trials (RCTs and CCTs) (including split-mouth studies) of adhesives used to attach orthodontic bands to molar teeth were selected. Patients with full arch fixed orthodontic appliance(s) who had bands attached to molars were included. All review authors

  6. Super ready: how a regional approach to Super Bowl EMS paid off.

    Science.gov (United States)

    Clancy, Terry; Cortacans, Henry P

    2014-07-01

    The Super Bowl and its associated activities represent one of the largest special events in the world. Super Bowl XLVIII was geographically unique because the NFL's and Super Bowl Host Committee's activities, venues and events encompassed two states and fell across numerous jurisdictions within six counties (Bergen, Hudson, Morris, Essex, Middlesex, and Manhattan).This Super Bowl was the first to do this. EMS was one of the largest operational components during this event. Last and most important, it is the people and relationships that make any planning initiative and event a success. Sit down and have a cup a coffee with your colleagues, partners and neighbors in and out of state to discuss your planning initiatives. Do it early-it will make your efforts less painful should an event of this magnitude come to a city near you!

  7. Acoustic Design of Super-light Structures

    DEFF Research Database (Denmark)

    Christensen, Jacob Ellehauge; Hertz, Kristian Dahl; Brunskog, Jonas

    aggregate (leca) along with a newly developed technology called pearl-chain reinforcement, which is a system for post-tensioning. Here, it is shown how to combine these technologies within a precast super-light slab element, while honoring the requirements of a holistic design. Acoustic experiments...

  8. Folded shapes with Super-Light Structures

    DEFF Research Database (Denmark)

    Castberg, Niels Andreas; Hertz, Kristian Dahl

    2012-01-01

    The use of folded shapes in structures has become more common, but it still costs problems because of construction issues and bending moments. The present paper deals with how the newly patented structural concept Super-Light structures (SLS) can be used to create folded shapes. SLS gives lighter...

  9. Single Image Super Resolution via Sparse Reconstruction

    NARCIS (Netherlands)

    Kruithof, M.C.; Eekeren, A.W.M. van; Dijk, J.; Schutte, K.

    2012-01-01

    High resolution sensors are required for recognition purposes. Low resolution sensors, however, are still widely used. Software can be used to increase the resolution of such sensors. One way of increasing the resolution of the images produced is using multi-frame super resolution algorithms. Limita

  10. Conformal anomaly of super Wilson loop

    Energy Technology Data Exchange (ETDEWEB)

    Belitsky, A.V., E-mail: andrei.belitsky@asu.edu [Department of Physics, Arizona State University, Tempe, AZ 85287-1504 (United States)

    2012-09-11

    Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in conformal theories when one uses dimensional regularization. The rotation matrix to the diagonal basis is found by means of computing the anomaly in the Ward identity for the conformal boost. Presently, we apply this ideology to the super Wilson loop. We compute the one-loop conformal anomaly for the super Wilson loop and find that the anomaly depends on its Grassmann coordinates. By subtracting this anomalous contribution from the super Wilson loop we restore its interpretation as a dual description for reduced non-MHV amplitudes which are expressed in terms of superconformal invariants.

  11. Super-Kamiokande worth full restoration

    CERN Multimedia

    Mishima, I

    2002-01-01

    While prospects are good that the SuperKamiokande facility will be partially repaired after an accident last November, the government has yet to confirm whether it will spend the estimated 2.5 billion yen needed for a full-scale restoration (1 page).

  12. Structural optimization of super-repellent surfaces

    DEFF Research Database (Denmark)

    Cavalli, Andrea; Bøggild, Peter; Okkels, Fridolin

    2013-01-01

    Micro-patterning is an effective way to achieve surfaces with extreme liquid repellency. This technique does not rely on chemical coatings and is therefore a promising concept for application in food processing and bio-compatibile coatings. This super-repellent behaviour is obtained by suspending...

  13. Facile preparation of super durable superhydrophobic materials.

    Science.gov (United States)

    Wu, Lei; Zhang, Junping; Li, Bucheng; Fan, Ling; Li, Lingxiao; Wang, Aiqin

    2014-10-15

    The low stability, complicated and expensive fabrication procedures seriously hinder practical applications of superhydrophobic materials. Here we report an extremely simple method for preparing super durable superhydrophobic materials, e.g., textiles and sponges, by dip coating in fluoropolymers (FPs). The morphology, surface chemical composition, mechanical, chemical and environmental stabilities of the superhydrophobic textiles were investigated. The results show how simple the preparation of super durable superhydrophobic textiles can be! The superhydrophobic textiles outperform their natural counterparts and most of the state-of-the-art synthetic superhydrophobic materials in stability. The intensive mechanical abrasion, long time immersion in various liquids and repeated washing have no obvious influence on the superhydrophobicity. Water drops are spherical in shape on the samples and could easily roll off after these harsh stability tests. In addition, this simple dip coating approach is applicable to various synthetic and natural textiles and can be easily scaled up. Furthermore, the results prove that a two-tier roughness is helpful but not essential with regard to the creation of super durable superhydrophobic textiles. The combination of microscale roughness of textiles and materials with very low surface tension is enough to form super durable superhydrophobic textiles. According to the same procedure, superhydrophobic polyurethane sponges can be prepared, which show high oil absorbency, oil/water separation efficiency and stability. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Pavement behaviour under the super single tyre

    CSIR Research Space (South Africa)

    Viljoen, AW

    1982-06-01

    Full Text Available Pavement behaviour under the super single tyre (SST) was investigated and compared with that under a conventional dual tyre (CDT). Contact areas and contact pressures over a range of loading conditions were measured and compared. Two approaches were...

  15. Typhoon effects on super-tall buildings

    Science.gov (United States)

    Li, Q. S.; Xiao, Y. Q.; Wu, J. R.; Fu, J. Y.; Li, Z. N.

    2008-06-01

    Full-scale measurement is considered to be the most reliable method for evaluating wind effects on buildings and structures. This paper presents selected results of wind characteristics and structural responses measured from four super-tall buildings, The Center (350 m high, 79 floors) in Hong Kong, Di Wang Tower (384 m high, 78 floors) in Shenzhen, CITIC Plaza Tower (391 m high, 80 floors) in Guangzhou and Jin Mao Building (421 m high, 88 floors) in Shanghai, during the passages of three typhoons. The field data such as wind speed, wind direction and acceleration responses, etc., were continuously measured from the super-tall buildings during the typhoons. Detailed analysis of the field data was conducted to investigate the characteristics of typhoon-generated wind and wind-induced vibrations of these super-tall buildings under typhoon conditions. The dynamic characteristics of the tall buildings were determined from the field measurements and comparisons with those calculated from the finite element (FE) models of the structures were made. Furthermore, the full-scale measurements were compared with wind tunnel results to evaluate the accuracy of the model test results and the adequacy of the techniques used in the wind tunnel tests. The results presented in this paper are expected to be of considerable interest and of use to researchers and professionals involved in designing super-tall buildings.

  16. Searching for Frozen Super Earth via Microlensing

    Science.gov (United States)

    Batista, V.; Beaulieu, J. P.; Cassan, A.; Coutures, C.; Donatowicz, J.; Fouqué, P.; Kubas, D.; Marquette, J. B.

    2009-04-01

    Microlensing planet hunt is a unique method to probe efficiently for frozen Super Earth orbiting the most common stars of our galaxy. It is nicely complementing the parameter space probed by very high accuracy radial velocity measurements and future space based detections of low mass transiting planets. In order to maximize the planet catch, the microlensing community is engaged in a total cooperation among the different groups (OGLE, MicroFUN, MOA, PLANET/RoboNET) by making the real time data available, and mutual informing/reporting about modeling efforts. Eight planets have been published so far by combinations of the different groups, 4 Jovian analogues, one Neptune and two Super Earth. Given the microlensing detection efficiency, it suggests that these Neptunes/Super Earths may be quite common. Using networks of dedicated 1-2m class telescopes, the microlensing community has entered a new phase of planet discoveries, and will be able to provide constraints on the abundance of frozen Super-Earths in the near future. Statistics about Mars to Earth mass planets, extending to the habitable zone will be achieved with space based wide field imagers (EUCLID) at the horizon 2017.

  17. Folded shapes with Super-Light Structures

    DEFF Research Database (Denmark)

    Castberg, Niels Andreas; Hertz, Kristian Dahl

    2012-01-01

    The use of folded shapes in structures has become more common, but it still costs problems because of construction issues and bending moments. The present paper deals with how the newly patented structural concept Super-Light structures (SLS) can be used to create folded shapes. SLS gives lighter...

  18. Advantages of super-light structures

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl

    2009-01-01

    Super-light structures with pearl-chain reinforcement is a new revolutionary technology that opens possibilities of building load-bearing structures much cheaper and with several other advantages compared to traditional constructions of concrete and steel. Some benefits are: 1 Half price or less. 2...

  19. Super-resolution near field imaging device

    DEFF Research Database (Denmark)

    2014-01-01

    Super-resolution imaging device comprising at least a first and a second elongated coupling element, each having a first transverse dimension at a first end and a second transverse dimension at a second end and being adapted for guiding light between their respective first and second ends, each...

  20. BREEDING SUPER-EARTHS AND BIRTHING SUPER-PUFFS IN TRANSITIONAL DISKS

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eve J.; Chiang, Eugene, E-mail: evelee@berkeley.edu, E-mail: echiang@astro.berkeley.edu [Department of Astronomy, University of California Berkeley, Berkeley, CA 94720-3411 (United States)

    2016-02-01

    The riddle posed by super-Earths (1–4R{sub ⊕}, 2–20M{sub ⊕}) is that they are not Jupiters: their core masses are large enough to trigger runaway gas accretion, yet somehow super-Earths accreted atmospheres that weigh only a few percent of their total mass. We show that this puzzle is solved if super-Earths formed late, as the last vestiges of their parent gas disks were about to clear. This scenario would seem to present fine-tuning problems, but we show that there are none. Ambient gas densities can span many (in one case up to 9) orders of magnitude, and super-Earths can still robustly emerge after ∼0.1–1 Myr with percent-by-weight atmospheres. Super-Earth cores are naturally bred in gas-poor environments where gas dynamical friction has weakened sufficiently to allow constituent protocores to gravitationally stir one another and merge. So little gas is present at the time of core assembly that cores hardly migrate by disk torques: formation of super-Earths can be in situ. The basic picture—that close-in super-Earths form in a gas-poor (but not gas-empty) inner disk, fed continuously by gas that bleeds inward from a more massive outer disk—recalls the largely evacuated but still accreting inner cavities of transitional protoplanetary disks. We also address the inverse problem presented by super-puffs: an uncommon class of short-period planets seemingly too voluminous for their small masses (4–10R{sub ⊕}, 2–6M{sub ⊕}). Super-puffs most easily acquire their thick atmospheres as dust-free, rapidly cooling worlds outside ∼1 AU where nebular gas is colder, less dense, and therefore less opaque. Unlike super-Earths, which can form in situ, super-puffs probably migrated in to their current orbits; they are expected to form the outer links of mean-motion resonant chains, and to exhibit greater water content. We close by confronting observations and itemizing remaining questions.

  1. Can mushrooms fix atmospheric nitrogen?

    Indian Academy of Sciences (India)

    H S Jayasinghearachchi; Gamini Seneviratne

    2004-09-01

    It is generally reported that fungi like Pleurotus spp. can fix nitrogen (N2). The way they do it is still not clear. The present study hypothesized that only associations of fungi and diazotrophs can fix N2. This was tested in vitro. Pleurotus ostreatus was inoculated with a bradyrhizobial strain nodulating soybean and P. ostreatus with no inoculation was maintained as a control. At maximum mycelial colonization by the bradyrhizobial strain and biofilm formation, the cultures were subjected to acetylene reduction assay (ARA). Another set of the cultures was evaluated for growth and nitrogen accumulation. Nitrogenase activity was present in the biofilm, but not when the fungus or the bradyrhizobial strain was alone. A significant reduction in mycelial dry weight and a significant increase in nitrogen concentration were observed in the inoculated cultures compared to the controls. The mycelial weight reduction could be attributed to C transfer from the fungus to the bradyrhizobial strain, because of high C cost of biological N2 fixation. This needs further investigations using 14C isotopic tracers. It is clear from the present study that mushrooms alone cannot fix atmospheric N2. But when they are in association with diazotrophs, nitrogenase activity is detected because of the diazotrophic N2 fixation. It is not the fungus that fixes N2 as reported earlier. Effective N2 fixing systems, such as the present one, may be used to increase protein content of mushrooms. Our study has implications for future identification of as yet unidentified N2 systems occurring in the environment.

  2. SuperB A High-Luminosity Asymmetric $e^+ e^-$ Super Flavour Factory : Conceptual Design Report

    CERN Document Server

    Bona, M.; Grauges Pous, E.; Colangelo, P.; De Fazio, F.; Palano, A.; Manghisoni, M.; Re, V.; Traversi, G.; Eigen, G.; Venturini, M.; Soni, N.; Bruschi, M.; De Castro, S.; Faccioli, P.; Gabrieli, A.; Giacobbe, B.; Semprini Cesare, N.; Spighi, R.; Villa, M.; Zoccoli, A.; Hearty, C.; McKenna, J.; Soni, A.; Khan, A.; Barniakov, A.Y.; Barniakov, M.Y.; Blinov, V.E.; Druzhinin, V.P.; Golubev, V.B.; Kononov, S.A.; Koop, I.A.; Kravchenko, E.A.; Levichev, E.B.; Nikitin, S.A.; Onuchin, A.P.; Piminov, P.A.; Serednyakov, S.I.; Shatilov, D.N.; Skovpen, Y.I.; Solodov, E.A.; Cheng, C.H.; Echenard, B.; Fang, F.; Hitlin, D.J.; Porter, F.C.; Asner, D.M.; Pham, T.N.; Fleischer, R.; Giudice, G.F.; Hurth, T.; Mangano, M.; Mancinelli, G.; Meadows, B.T.; Schwartz, A.J.; Sokoloff, M.D.; Soffer, A.; Beard, C.D.; Haas, T.; Mankel, R.; Hiller, G.; Ball, P.; Pappagallo, M.; Pennington, M.R.; Gradl, W.; Playfer, S.; Abada, A.; Becirevic, D.; Descotes-Genon, S.; Pene, O.; Andreotti, D.; Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabresi, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.; Stancari, G.; Anulli, F.; Baldini-Ferroli, R.; Biagini, M.E.; Boscolo, M.; Calcaterra, A.; Drago, A.; Finocchiaro, G.; Guiducci, S.; Isidori, G.; Pacetti, S.; Patteri, P.; Peruzzi, I.M.; Piccolo, M.; Preger, M.A.; Raimondi, P.; Rama, M.; Vaccarezza, C.; Zallo, A.; Zobov, M.; De Sangro, R.; Buzzo, A.; Lo Vetere, M.; Macri, M.; Monge, M.R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Tosi, S.; Matias, J.; Panduro Vazquez, W.; Borzumati, F.; Eyges, V.; Prell, S.A.; Pedlar, T.K.; Korpar, S.; Pestonik, R.; Staric, M.; Neubert, M.; Denig, A.G.; Nierste, U.; Agoh, T.; Ohmi, K.; Ohnishi, Y.; Fry, J.R.; Touramanis, C.; Wolski, A.; Golob, B.; Krizan, P.; Flaecher, H.; Bevan, A.J.; Di Lodovico, F.; George, K.A.; Barlow, R.; Lafferty, G.; Jawahery, A.; Roberts, D.A.; Simi, G.; Patel, P.M.; Robertson, S.H.; Lazzaro, A.; Palombo, F.; Kaidalov, A.; Buras, A.J.; Tarantino, C.; Buchalla, G.; Sanda, A.I.; D'Ambrosio, G.; Ricciardi, G.; Bigi, I.; Jessop, C.P.; Losecco, J.M.; Honscheid, K.; Arnaud, N.; Chehab, R.; Fedala, Y.; Polci, F.; Roudeau, P.; Sordini, V.; Soskov, V.; Stocchi, A.; Variola, A.; Vivoli, A.; Wormser, G.; Zomer, F.; Bertolin, A.; Brugnera, R.; Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Bonneaud, G.R.; Lombardo, V.; Calderini, G.; Ratti, L.; Speziali, V.; Biasini, M.; Covarelli, R.; Manoni, E.; Servoli, L.; Angelini, C.; Batignani, G.; Bettarini, S.; Bosi, F.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Dell'Orso, M.; Forti, F.; Giannetti, P.; Giorgi, M.; Lusiani, A.; Marchiori, G.; Massa, M.; Mazur, M.A.; Morsani, F.; Neri, N.; Paoloni, E.; Raffaelli, F.; Rizzo, G.; Walsh, J.; Braun, V.; Lenz, A.; Adams, G.S.; Danko, I.Z.; Baracchini, E.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Gaspero, Mario; Jackson, P.; Martinelli, G.; Mazzoni, M.A.; Morganti, Silvio; Piredda, G.; Renga, F.; Silvestrini, L.; Voena, C.; Catani, L.; Di Ciaccio, A.; Messi, R.; Santovetti, E.; Satta, A.; Ciuchini, M.; Lubicz, V.; Wilson, F.F.; Godang, R.; Chen, X.; Liu, H.; Park, W.; Purohit, M.; Trivedi, A.; White, R.M.; Wilson, J.R.; Allen, M.T.; Aston, D.; Bartoldus, R.; Brodsky, S.J.; Cai, Y.; Coleman, J.; Convery, M.R.; DeBarger, S.; Dingfelder, J.C.; Dubois-Felsmann, G.P.; Ecklund, S.; Fisher, A.S.; Haller, G.; Heifets, S.A.; Kaminski, J.; Kelsey, M.H.; Kocian, M.L.; Leith, D.W.G.S.; Li, N.; Luitz, S.; Luth, V.; MacFarlane, D.; Messner, R.; Muller, D.R.; Nosochkov, Y.; Novokhatski, A.; Pivi, M.; Ratcliff, B.N.; Roodman, A.; Schwiening, J.; Seeman, J.; Snyder, A.; Sullivan, M.; Va'Vra, J.; Wienands, U.; Wisniewski, W.; Stoeck, H.; Cheng, H.Y.; Li, H.N.; Keum, Y.Y.; Gronau, M.; Grossman, Y.; Bianchi, F.; Gamba, D.; Gambino, P.; Marchetto, F.; Menichetti, Ezio A.; Mussa, R.; Pelliccioni, M.; Dalla Betta, G.F.; Bomben, M.; Bosisio, L.; Cartaro, C.; Lanceri, L.; Vitale, L.; Azzolini, V.; Bernabeu, J.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D.A.; Oyanguren, A.; Paradisi, P.; Pich, A.; Sanchis-Lozano, M.A.; Kowalewski, Robert V.; Roney, J.M.; Back, J.J.; Gershon, T.J.; Harrison, P.F.; Latham, T.E.; Mohanty, G.B.; Petrov, A.A.; Pierini, M.; INFN

    2007-01-01

    The physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment.

  3. Properties of Super-Poisson Processes and Super-Random Walks with Spatially Dependent Branching Rates

    Institute of Scientific and Technical Information of China (English)

    Yan Xia REN

    2008-01-01

    The global supports of super-Poisson processes and super-random walks with a branching mechanism ψ(z)=z2 and constant branching rate are known to be noncompact. It turns out that, for any spatially dependent branching rate, this property remains true. However, the asymptotic extinction property for these two kinds of superprocesses depends on the decay rate of the branching-rate function at infinity.

  4. Super-resolution optical microscopy study of telomere structure

    Science.gov (United States)

    Phipps, Mary Lisa; Goodwin, Peter M.; Martinez, Jennifer S.; Goodwin, Edwin H.

    2016-09-01

    Chromosome ends are shielded from exonucleolytic attack and inappropriate end-joining by terminal structures called telomeres; these structures are potential targets for anticancer drugs. Telomeres are composed of a simple DNA sequence (5‧-TTAGGG-3‧ in humans) repeated more than a thousand times, a short 3‧ single-stranded overhang, and numerous proteins. Electron microscopy has shown that the 3‧ overhang pairs with the complementary strand at an internal site creating a small displacement loop and a large double-stranded "t-loop." Our goal is to determine whether all telomeres adopt the t-loop configuration, or whether there are two or more distinct configurations. Progress in optimizing super-resolution (SR) microscopy for this ongoing investigation is reported here. Results suggest that under certain conditions sample preparation procedures may disrupt chromatin by causing loss of nucleosomes. This finding may limit the use of SR microscopy in telomere studies.

  5. Super-Chern-Simons Theory as Superstring Theory

    CERN Document Server

    Grassi, P A

    2004-01-01

    Superstrings and topological strings with supermanifolds as target space play a central role in the recent developments in string theory. Nevertheless the rules for higher-genus computations are still unclear or guessed in analogy with bosonic and fermionic strings. Here we present a common geometrical setting to develop systematically the prescription for amplitude computations. The geometrical origin of these difficulties is the theory of integration of superforms. We provide a translation between the theory of supermanifolds and topological strings with supertarget space. We show how in this formulation one can naturally construct picture changing operators to be inserted in the correlation functions to soak up the zero modes of commuting ghost and we derive the amplitude prescriptions from the coupling with an extended topological gravity on the worldsheet. As an application we consider a simple model on R^(3|2) leading to super-Chern-Simons theory.

  6. A generalized super AKNS hierarchy associated with Lie superalgebra sl(2|1) and its super bi-Hamiltonian structure

    Science.gov (United States)

    Han, Jingwei; Yu, Jing

    2017-03-01

    Starting from a 3 × 3 matrix-valued spectral problem associated with a Lie superalgebra sl(2|1), a generalized super Ablowitz-Kaup-Newell-Segur (AKNS) hierarchy is derived. The resulting super AKNS hierarchy has a super bi-Hamiltonian structure by the supertrace identity.

  7. Super SI燃烧方式试验研究%Super SI Combustion Mode

    Institute of Scientific and Technical Information of China (English)

    沈义涛; 吕世亮; 尹琪; 杨嘉林; 高卫民

    2011-01-01

    The super spark ignition (Super SI) combustion mode, which was the ignition combustion of lean mixture at the temperature of close spontaneous combustion, was researched and its combustion characteristic and feasibility were analyzed.The results indicate that the increase of intake temperature can reduce the cyclic variation of Pmi obviously, shorten the combustion duration and extend the lean limit of SI combustion under the condition of lean mixture. Accordingly, Super SI combustion has the advantages of high thermal efficiency and controllable combustion process.%研究了Super Spark Ignition(Super SI)燃烧方式,即稀薄混合气在近自燃温度状态下点燃燃烧,分析了这种燃烧方式的可行性和燃烧特性.研究结果表明,混合气稀薄时提高发动机的进气温度可显著降低平均指示压力(pmi)的循环波动,缩短燃烧持续期,拓展点燃燃烧的稀薄极限;Super SI燃烧方式具有热效率高、燃烧过程可控的优点.

  8. The 2015 super-resolution microscopy roadmap

    Science.gov (United States)

    Hell, Stefan W.; Sahl, Steffen J.; Bates, Mark; Zhuang, Xiaowei; Heintzmann, Rainer; Booth, Martin J.; Bewersdorf, Joerg; Shtengel, Gleb; Hess, Harald; Tinnefeld, Philip; Honigmann, Alf; Jakobs, Stefan; Testa, Ilaria; Cognet, Laurent; Lounis, Brahim; Ewers, Helge; Davis, Simon J.; Eggeling, Christian; Klenerman, David; Willig, Katrin I.; Vicidomini, Giuseppe; Castello, Marco; Diaspro, Alberto; Cordes, Thorben

    2015-11-01

    Far-field optical microscopy using focused light is an important tool in a number of scientific disciplines including chemical, (bio)physical and biomedical research, particularly with respect to the study of living cells and organisms. Unfortunately, the applicability of the optical microscope is limited, since the diffraction of light imposes limitations on the spatial resolution of the image. Consequently the details of, for example, cellular protein distributions, can be visualized only to a certain extent. Fortunately, recent years have witnessed the development of ‘super-resolution’ far-field optical microscopy (nanoscopy) techniques such as stimulated emission depletion (STED), ground state depletion (GSD), reversible saturated optical (fluorescence) transitions (RESOLFT), photoactivation localization microscopy (PALM), stochastic optical reconstruction microscopy (STORM), structured illumination microscopy (SIM) or saturated structured illumination microscopy (SSIM), all in one way or another addressing the problem of the limited spatial resolution of far-field optical microscopy. While SIM achieves a two-fold improvement in spatial resolution compared to conventional optical microscopy, STED, RESOLFT, PALM/STORM, or SSIM have all gone beyond, pushing the limits of optical image resolution to the nanometer scale. Consequently, all super-resolution techniques open new avenues of biomedical research. Because the field is so young, the potential capabilities of different super-resolution microscopy approaches have yet to be fully explored, and uncertainties remain when considering the best choice of methodology. Thus, even for experts, the road to the future is sometimes shrouded in mist. The super-resolution optical microscopy roadmap of Journal of Physics D: Applied Physics addresses this need for clarity. It provides guidance to the outstanding questions through a collection of short review articles from experts in the field, giving a thorough

  9. Super-resolution mbPAINT for optical localization of single-stranded DNA.

    Science.gov (United States)

    Chen, Jixin; Bremauntz, Alberto; Kisley, Lydia; Shuang, Bo; Landes, Christy F

    2013-10-09

    We demonstrate the application of superlocalization microscopy to identify sequence-specific portions of single-stranded DNA (ssDNA) with sequence resolution of 50 nucleotides, corresponding to a spatial resolution of 30 nm. Super-resolution imaging was achieved using a variation of a single-molecule localization method, termed as "motion blur" point accumulation for imaging in nanoscale topography (mbPAINT). The target ssDNA molecules were immobilized on the substrate. Short, dye-labeled, and complementary ssDNA molecules stochastically bound to the target ssDNA, with repeated binding events allowing super-resolution. Sequence specificity was demonstrated via the use of a control, noncomplementary probe. The results support the possibility of employing relatively inexpensive short ssDNAs to identify gene sequence specificity with improved resolution in comparison to the existing methods.

  10. The Solution Construction of Heterotic Super-Liouville Model

    Institute of Scientific and Technical Information of China (English)

    YANG Zhan-Ying; ZHEN Yi

    2001-01-01

    We investigate the heterotic super-Liouville model on the base of the basic Lie super-algebra Osp(1|2).Using the super extension of Leznov-Saveliev analysis and Drinfeld Sokolov linear system, we construct the explicit solution of the heterotic super-Liouville system in component form. We also show that the solutions are local and periodic by calculating the exchange relation of the solution. Finally starting from the action of heterotic super-Liou ville model, we obtain the conserved current and conserved charge which possessed the BR ST properties.

  11. Radiation protection design of the Super-Fragment-Separator at the FAIR facility; Strahlenschutzplanung fuer den Super-Fragment-Separator bei FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Lang, R.; Conrad, I.; Kozlova, E.; Radon, T.; Stuman, F.; Weick, H.; Winkler, M. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Fehrenbacher, G. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); FAIR - Facility for Antiproton and Ion Research in Europe GmbH, Darmstadt (Germany)

    2015-07-01

    The Super FRagment- Separator (Super-FRS) at FAIR will produce atomic nuclei with an exotic ratio of protons to neutrons and demands highest standards of the constructional shielding and the handling process of activated components due to the required high intensities of the ion beam. The relevant sources of radiation, especially neutron radiation, resulting from the interaction of the accelerated ion beam with matter will be explained. In the vicinity of the pre-separator beam line, a high level of radioactive activation of the target (approx. 10{sup 11} Bq) and the beamcatcher (approx. 10{sup 13} Bq) is expected. Furthermore, the handling of activated components is explained and the concept of component handling and service with a specially manufactured shielding cask is also an important part of the ongoing design process. Finally, the hot cell, which is located in the same building, is presented. Radioactive components will be serviced, stored or conditioned for disposal therein.

  12. Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

    Directory of Open Access Journals (Sweden)

    Meng-Tsen Ke

    2016-03-01

    Full Text Available Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2. SeeDB2 matches the refractive indices of fixed tissues to that of immersion oil (1.518, thus minimizing both light scattering and spherical aberrations. During the clearing process, fine morphology and fluorescent proteins were highly preserved. SeeDB2 enabled super-resolution microscopy of various tissue samples up to a depth of >100 μm, an order of magnitude deeper than previously possible under standard mounting conditions. Using this approach, we demonstrate accumulation of inhibitory synapses on spine heads in NMDA-receptor-deficient neurons. In the fly medulla, we found unexpected heterogeneity in axon bouton orientations among Mi1 neurons, a part of the motion detection circuitry. Thus, volumetric super-resolution microscopy of cleared tissues is a powerful strategy in connectomic studies at synaptic levels.

  13. STED super-resolution microscopy of clinical paraffin-embedded human rectal cancer tissue.

    Science.gov (United States)

    Ilgen, Peter; Stoldt, Stefan; Conradi, Lena-Christin; Wurm, Christian Andreas; Rüschoff, Josef; Ghadimi, B Michael; Liersch, Torsten; Jakobs, Stefan

    2014-01-01

    Formalin fixed and paraffin-embedded human tissue resected during cancer surgery is indispensable for diagnostic and therapeutic purposes and represents a vast and largely unexploited resource for research. Optical microscopy of such specimen is curtailed by the diffraction-limited resolution of conventional optical microscopy. To overcome this limitation, we used STED super-resolution microscopy enabling optical resolution well below the diffraction barrier. We visualized nanoscale protein distributions in sections of well-annotated paraffin-embedded human rectal cancer tissue stored in a clinical repository. Using antisera against several mitochondrial proteins, STED microscopy revealed distinct sub-mitochondrial protein distributions, suggesting a high level of structural preservation. Analysis of human tissues stored for up to 17 years demonstrated that these samples were still amenable for super-resolution microscopy. STED microscopy of sections of HER2 positive rectal adenocarcinoma revealed details in the surface and intracellular HER2 distribution that were blurred in the corresponding conventional images, demonstrating the potential of super-resolution microscopy to explore the thus far largely untapped nanoscale regime in tissues stored in biorepositories.

  14. Variable-intercept panel model for deformation zoning of a super-high arch dam.

    Science.gov (United States)

    Shi, Zhongwen; Gu, Chongshi; Qin, Dong

    2016-01-01

    This study determines dam deformation similarity indexes based on an analysis of deformation zoning features and panel data clustering theory, with comprehensive consideration to the actual deformation law of super-high arch dams and the spatial-temporal features of dam deformation. Measurement methods of these indexes are studied. Based on the established deformation similarity criteria, the principle used to determine the number of dam deformation zones is constructed through entropy weight method. This study proposes the deformation zoning method for super-high arch dams and the implementation steps, analyzes the effect of special influencing factors of different dam zones on the deformation, introduces dummy variables that represent the special effect of dam deformation, and establishes a variable-intercept panel model for deformation zoning of super-high arch dams. Based on different patterns of the special effect in the variable-intercept panel model, two panel analysis models were established to monitor fixed and random effects of dam deformation. Hausman test method of model selection and model effectiveness assessment method are discussed. Finally, the effectiveness of established models is verified through a case study.

  15. SuperCam, a 64-pixel heterodyne imaging array for the 870 micron atmospheric window

    CERN Document Server

    Groppi, C; Kulesa, C; Pütz, P; Golish, D; Gensheimer, P; Hedden, A; Bussmann, S; Weinreb, S; Kuiper, T; Kooi, J; Jones, G; Bardin, J; Mani, H S; Lichtenberger, A; Narayanan, G; Groppi, Christopher; Walker, Christopher; Kulesa, Craig; Puetz, Patrick; Golish, Dathon; Gensheimer, Paul; Hedden, Abigail; Bussmann, Shane; Weinreb, Sander; Kuiper, Thomas; Kooi, Jacob; Jones, Glenn; Bardin, Joseph; Mani, Hamdi; Lichtenberger, Arthur; Narayanan, Gopal

    2006-01-01

    We report on the development of SuperCam, a 64 pixel, superheterodyne camera designed for operation in the astrophysically important 870 micron atmospheric window. SuperCam will be used to answer fundamental questions about the physics and chemistry of molecular clouds in the Galaxy and their direct relation to star and planet formation. The advent of such a system will provide an order of magnitude increase in mapping speed over what is now available and revolutionize how observational astronomy is performed in this important wavelength regime. Unlike the situation with bolometric detectors, heterodyne receiver systems are coherent, retaining information about both the amplitude and phase of the incident photon stream. From this information a high resolution spectrum of the incident light can be obtained without multiplexing. SuperCam will be constructed by stacking eight, 1x8 rows of fixed tuned, SIS mixers. The IF output of each mixer will be connected to a low-noise, broadband MMIC amplifier integrated in...

  16. STED super-resolution microscopy of clinical paraffin-embedded human rectal cancer tissue.

    Directory of Open Access Journals (Sweden)

    Peter Ilgen

    Full Text Available Formalin fixed and paraffin-embedded human tissue resected during cancer surgery is indispensable for diagnostic and therapeutic purposes and represents a vast and largely unexploited resource for research. Optical microscopy of such specimen is curtailed by the diffraction-limited resolution of conventional optical microscopy. To overcome this limitation, we used STED super-resolution microscopy enabling optical resolution well below the diffraction barrier. We visualized nanoscale protein distributions in sections of well-annotated paraffin-embedded human rectal cancer tissue stored in a clinical repository. Using antisera against several mitochondrial proteins, STED microscopy revealed distinct sub-mitochondrial protein distributions, suggesting a high level of structural preservation. Analysis of human tissues stored for up to 17 years demonstrated that these samples were still amenable for super-resolution microscopy. STED microscopy of sections of HER2 positive rectal adenocarcinoma revealed details in the surface and intracellular HER2 distribution that were blurred in the corresponding conventional images, demonstrating the potential of super-resolution microscopy to explore the thus far largely untapped nanoscale regime in tissues stored in biorepositories.

  17. On Fixing number of Functigraphs

    OpenAIRE

    Fazil, Muhammad; Javaid, Imran; Murtaza, Muhammad

    2016-01-01

    The fixing number of a graph $G$ is the order of the smallest subset $S$ of its vertex set $V(G)$ such that stabilizer of $S$ in $G$, $\\Gamma_{S}(G)$ is trivial. Let $G_{1}$ and $G_{2}$ be disjoint copies of a graph $G$, and let $g:V(G_{1})\\rightarrow V(G_{2})$ be a function. A functigraph $F_{G}$ consists of the vertex set $V(G_{1})\\cup V(G_{2})$ and the edge set $E(G_{1})\\cup E(G_{2})\\cup \\{uv:v=g(u)\\}$. In this paper, we study the behavior of the fixing number in passing from $G$ to $F_{G}...

  18. Oral rehabilitation with fixed prosthesis

    OpenAIRE

    Watanabe Velásquez, Romel; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú.; Salcedo Moncada, Doris; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú.; Ochoa Tataje, Julio; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú; Horna Palomino, Hernán; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú.; Herrera Cisneros, Marco; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú.; Paz Fernández, Juan José; Dpto. Académico Estomatología Rehabilitadora. Facultad Odontología. UNMSM. Lima, Perú.

    2014-01-01

    This treatment was carried out in a 58 years old male patient, who has had the antecedent of a car crash accident two years before; he loosed several teeth and fractured others. Pulp necrosis and alteration of occlusal plane occurred. Because of the pathologies presented, it was installed a multidisciplinary treatment phase having periodontal, endodontic, surgical and orthodontic procedures, tehe installation of posts, crowns and fixed bridges. Treatment was carried out for five months. El...

  19. Development of a New Foxtail Millet Germplasm with Super Early Maturity and High Iron Content

    Institute of Scientific and Technical Information of China (English)

    LIU Zheng-li; SUN Shi-xian; CHENG Ru-hong; HUANG Wen-sheng; LIU Jun-xin; QU Zhu-feng; XIA Xue-yan; SHI Zhi-gang

    2006-01-01

    Super Early Maturation No.2 is a new foxtail millet germplasm developed by using the targeted-character-gene-bankbreeding method. It has several outstanding characteristics. (1) Super early maturity. It can normally mature in Bashang,Hebei Province, China, where the altitude is around 1 400 meters, and it needs 1 650℃ of effective accumulated temperature in the growing period. (2) Millet is rich in iron. The iron content of the millet of Super Early Maturation No.2 is 54.10 mg kg-1,which is 62.0% higher than the average iron content of the foxtail millet varieties in China. (3) High crude fat content. Its crude fat content is 6.24%, which is 54.1% higher than the average content of foxtail millet varieties in China. (4) High crude protein content. The average of the crude protein content of all the foxtail millet varieties in China is 12.71%, only5% varieties surpass 14%, however, the crude protein content of Super Early Maturation No.2 is 14.36%, which is rare in improved varieties of foxtail millet in China. (5) Overall characteristics are good.

  20. A possible mechanism to detect super-earth formation in protoplanetary disks

    Science.gov (United States)

    Dong, Ruobing; Chiang, Eugene; Li, Hui; Li, Shengtai

    2017-06-01

    Using combined gas+dust global hydrodynamics and radiative transfer simulations, we calculate the distribution of gas and sub-mm-sized dust in protoplanetary disks with a super-Earth at tens of AU, and examine observational signatures of such systems in resolved observations. We confirm previous results that in a typical disk with a low viscosity ($\\alpha\\lesssim10^{-4}$), a super-Earth is able to open two gaps at $\\sim$scale-height away around its orbit in $\\sim$mm-sized dust (St$\\sim$0.01), due to differential dust drift in a perturbed gas background. Additional rings and gaps may also be produced under certain conditions. These features, particularly a signature ``double-gap'' feature, can be detected in a Taurus target by ALMA in dust continuum under an angular resolution of $\\sim0\\arcsec.025$ with two hours of integration. The features are robust --- it can survive in a variety of background disk profiles, withstand modest planetary radial migration ($|r/\\dot{r}|\\sim$ a few Myr), and last for thousands of orbits. Multiple ring/gap systems observed by ALMA were typically modeled using multiple (Saturn-to-Jupiter sized) planets. Here, we argue that a single super-Earth in a low viscosity disk could produce multiple rings and gaps as well. By examining the prevalence of such features in nearby disks, upcoming high angular resolution ALMA surveys may infer how common super-Earth formation events are at tens of au.

  1. Detection of retroviral super-infection from non-invasive samples.

    Directory of Open Access Journals (Sweden)

    Adeelia S Goffe

    Full Text Available While much attention has been focused on the molecular epidemiology of retroviruses in wild primate populations, the correlated question of the frequency and nature of super-infection events, i.e., the simultaneous infection of the same individual host with several strains of the same virus, has remained largely neglected. In particular, methods possibly allowing the investigation of super-infection from samples collected non-invasively (such as faeces have never been properly compared. Here, we fill in this gap by assessing the costs and benefits of end-point dilution PCR (EPD-PCR and multiple bulk-PCR cloning, as applied to a case study focusing on simian foamy virus super-infection in wild chimpanzees (Pan troglodytes. We show that, although considered to be the gold standard, EPD-PCR can lead to massive consumption of biological material when only low copy numbers of the target are expected. This constitutes a serious drawback in a field in which rarity of biological material is a fundamental constraint. In addition, we demonstrate that EPD-PCR results (single/multiple infection; founder strains can be well predicted from multiple bulk-PCR clone experiments, by applying simple statistical and network analyses to sequence alignments. We therefore recommend the implementation of the latter method when the focus is put on retroviral super-infection and only low retroviral loads are encountered.

  2. Zirconia in fixed implant prosthodontics.

    Science.gov (United States)

    Guess, Petra Christine; Att, Wael; Strub, Joerg Rudolf

    2012-10-01

    CAD/CAM technology in combination with zirconia ceramic has increasingly gained popularity in implant dentistry. This narrative review presents the current knowledge on zirconia utilized as framework material for implant-borne restorations and implant abutments, laboratory tests and developments, clinical performance, and possible future trends for implant dentistry are addressed. A review of available literature from 1990 through 2010 was conducted with search terms zirconia,"implants,"abutment,"crown," and "fixed dental prosthesis" using electronic databases (PubMed) and manual searching. Latest applications of zirconia in implant dentistry include implant abutments, multiple unit and full-arch frameworks as well as custom-made bars to support fixed and removable prostheses. High biocompatibility, low bacterial surface adhesion as well as favorable chemical properties of zirconia ceramics are reported. Zirconia stabilized with yttrium oxide exhibits high flexural strength and fracture toughness due to a transformation toughening mechanism. Preliminary clinical data confirmed the high stability of zirconia for abutments and as a framework material for implant borne crowns and fixed dental prostheses. Zirconia abutment or framework damage has rarely been encountered. However, veneering porcelain fractures are the most common technical complication in implant-supported zirconia restorations. These porcelain veneer failures have led to concerns regarding differences in coefficient of thermal expansions between core and veneering porcelain and their respective processing techniques. As presently evidence of clinical long-term data is missing, caution with regard to especially extensive implant-borne zirconia frameworks is recommended. © 2010 Wiley Periodicals, Inc.

  3. A fixed-point farrago

    CERN Document Server

    Shapiro, Joel H

    2016-01-01

    This text provides an introduction to some of the best-known fixed-point theorems, with an emphasis on their interactions with topics in analysis. The level of exposition increases gradually throughout the book, building from a basic requirement of undergraduate proficiency to graduate-level sophistication. Appendices provide an introduction to (or refresher on) some of the prerequisite material and exercises are integrated into the text, contributing to the volume’s ability to be used as a self-contained text. Readers will find the presentation especially useful for independent study or as a supplement to a graduate course in fixed-point theory. The material is split into four parts: the first introduces the Banach Contraction-Mapping Principle and the Brouwer Fixed-Point Theorem, along with a selection of interesting applications; the second focuses on Brouwer’s theorem and its application to John Nash’s work; the third applies Brouwer’s theorem to spaces of infinite dimension; and the fourth rests ...

  4. Design and Implementation of Fixed Point Arithmetic Unit

    Directory of Open Access Journals (Sweden)

    S Ramanathan

    2016-06-01

    Full Text Available This paper aims at Implementation of Fixed Point Arithmetic Unit. The real number is represented in Qn.m format where n is the number of bits to the left of the binary point and m is the number of bits to the right of the binary point. The Fixed Point Arithmetic Unit was designed using Verilog HDL. The Fixed Point Arithmetic Unit incorporates adder, multiplier and subtractor. We carried out the simulations in ModelSim and Cadence IUS, used Cadence RTL Compiler for synthesis and used Cadence SoC Encounter for physical design and targeted 180 nm Technology for ASIC implementation. From the synthesis result it is found that our design consumes 1.524 mW of power and requires area 20823.26 μm2 .

  5. SuperTools Test and Evaluation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Mannos, Tom J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Mixed Signal ASIC Design

    2017-01-01

    Superconducting electronics (SCE) represents a potential path to efficient exascale computing for HPC and data center applications, but SCE-based circuit design lags far behind its CMOS equivalent. IARPA’s ongoing C3 program and its developing SuperTools program aim to jumpstart SCE R&D with the near-term goal of producing a high-speed, low-energy, 64-bit RISC processor using Josephson Junction based logic cells. SuperTools performers will develop software tools for efficient SCE design and accurate simulation and characterization of JJ-based circuits, which include the RSFQ, RQL, and AQFP logic families. T&E teams from NIST, MIT Lincoln Lab, Berkeley Lab, and Sandia National Labs will evaluate the tools and fabricate test circuits to compare with simulated results. The five-year, three-phase program includes 48 performer deliverables, three annual technical exchange meetings, and annual site visits.

  6. Italian super-eruption larger than thought

    Science.gov (United States)

    Schultz, Colin

    2012-07-01

    Recent research suggested that the super-eruption of the Campi Flegrei caldera volcano in southern Italy about 40,000 years ago may have played a part in wiping out, or forcing the migration of, the Neanderthal and modern human populations in the eastern Mediterranean regions that were covered in ash. Now a new modeling study by Costa et al. suggests that this eruption may have been even larger than previously thought. This Campi Flegrei eruption produced a widespread ash layer known as Campanian Ignimbrite (CI). Using ash thickness measurements collected at 115 sites and a three-dimensional ash dispersal model, the researchers found that the CI super-eruption would have spread 250-300 cubic kilometers of ash across a 3.7-million-square kilometer region—2 to 3 times previous ash volume estimates.

  7. Optical super-resolution microscopy in neurobiology.

    Science.gov (United States)

    Sigrist, Stephan J; Sabatini, Bernardo L

    2012-02-01

    Understanding the highly plastic nature of neurons requires the dynamic visualization of their molecular and cellular organization in a native context. However, due to the limited resolution of standard light microscopy, many of the structural specializations of neurons cannot be resolved. A recent revolution in light microscopy has given rise to several super-resolution light microscopy methods yielding 2-10-fold higher resolution than conventional microscopy. We here describe the principles behind these techniques as well as their application to the analysis of the molecular architecture of the synapse. Furthermore, we discuss the potential for continued development of super-resolution microscopy as necessary for live imaging of neuronal structure and function in the brain.

  8. (Super-)renormalizably dressed black holes

    CERN Document Server

    Ayón-Beato, Eloy; Méndez-Zavaleta, Julio A

    2015-01-01

    Black holes supported by self-interacting conformal scalar fields can be considered as renormalizably dressed since the conformal potential is nothing but the top power-counting renormalizable self-interaction in the relevant dimension. On the other hand, potentials defined by powers which are lower than the conformal one are also phenomenologically relevant since they are in fact super-renormalizable. In this work we provide a new map that allows to build black holes dressed with all the (super-)renormalizable contributions starting from known conformal seeds. We explicitly construct several new examples of these solutions in dimensions $D=3$ and $D=4$, including not only stationary configurations but also time-dependent ones.

  9. Super/subradiant second harmonic generation

    Science.gov (United States)

    Koganov, Gennady A.; Shuker, Reuben

    2017-04-01

    A scheme for active second harmonics generation is suggested. The system comprises N three-level atoms in ladder configuration, situated into a resonant cavity. The system generates the field whose frequency is twice the frequency of the pumping laser, and the field phase is locked to the phase of the pumping field. It is found that the system can lase in either superradiant or subradiant regime, depending on the number of atoms N. When N passes some critical value the transition from the super to subradiance occurs in a phase-transition-like manner. Stability study of the steady state supports this conclusion. For experimental realization of the super/subradiant second harmonics generation we propose semiconductor quantum well structures, superconducting quantum circuits, and evanescently coupled waveguides in which equally spaced levels relevant to this study exist.

  10. Robust super-resolution without regularization

    Energy Technology Data Exchange (ETDEWEB)

    Pham, T Q [Canon Information Systems Research Australia, 1 Thomas Holt drive, North Ryde, NSW 2113 (Australia); Vliet, L J v [Quantitative Imaging Group, Department of Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft (Netherlands); Schutte, K [Electro-Optics Group, TNO Defence, Security and Safety, PO Box 96864, 2509 JG The Hague (Netherlands)

    2008-07-15

    Super-resolution restoration is the problem of restoring a high-resolution scene from multiple degraded low-resolution images under motion. Due to imaging blur and noise, this problem is ill-posed. Additional constraints such as smoothness of the solution (i.e. regularization) is often required to obtain a stable solution. While regularizing the cost function is a standard practice in image restoration, we propose a restoration algorithm that does not require this extra regularization term. The robustness of the algorithm is achieved by a robust error norm that does not response to intensity outliers. With the outliers suppressed, our solution behaves similarly to a maximum-likelihood solution under the presence of Gaussian noise. The effectiveness of our algorithm is demonstrated with super-resolution restoration of real infrared image sequences under severe aliasing and intensity outliers.

  11. Penrose Pixels for Super-Resolution.

    Science.gov (United States)

    Ben-Ezra, M; Lin, Zhouchen; Wilburn, Bennett; Zhang, Wei

    2011-07-01

    We present a novel approach to reconstruction-based super-resolution that uses aperiodic pixel tilings, such as a Penrose tiling or a biological retina, for improved performance. To this aim, we develop a new variant of the well-known error back projection super-resolution algorithm that makes use of the exact detector model in its back projection operator for better accuracy. Pixels in our model can vary in shape and size, and there may be gaps between adjacent pixels. The algorithm applies equally well to periodic or aperiodic pixel tilings. We present analysis and extensive tests using synthetic and real images to show that our approach using aperiodic layouts substantially outperforms existing reconstruction-based algorithms for regular pixel arrays. We close with a discussion of the feasibility of manufacturing CMOS or CCD chips with pixels arranged in Penrose tilings.

  12. Temporal super resolution using variational methods

    DEFF Research Database (Denmark)

    Keller, Sune Høgild; Lauze, Francois Bernard; Nielsen, Mads

    2010-01-01

    and intensities are calculated simultaneously in a multiresolution setting. A frame doubling version of our algorithm is implemented and in testing it, we focus on making the motion of high contrast edges to seem smooth and thus reestablish the illusion of motion pictures.......Temporal super resolution (TSR) is the ability to convert video from one frame rate to another and is as such a key functionality in modern video processing systems. A higher frame rate than what is recorded is desired for high frame rate displays, for super slow-motion, and for video/film format...... conversion (where also lower frame rates than recorded is sometimes required). We discuss and detail the requirements imposed by the human visual system (HVS) on TSR algorithms, of which the need for (apparent) fluid motion, also known as the phi-effect, is the principal one. This problem is typically...

  13. Super-pharm的生意经

    Institute of Scientific and Technical Information of China (English)

    韦少雯

    2006-01-01

    Super-pharm,这家可直译为“超级药店”的以色列最大的药品、化妆品及个人护理品零售企业,是由全球排名前几十位的亿万富翁、犹太人Murray Koffler创立的家族企业。

  14. Super Resolution Imaging Applied to Scientific Images

    Science.gov (United States)

    2007-05-01

    investigator, (3) development of Papoulis -Gerchberg method to implement the analytic continuation of spectral details, (4) exploration of contourlet and...off with noise present in the observation. In [30] we make use of Papoulis -Gerchberg algorithm of signal extrapolation to perform Image super...we have used a training database consisting of high resolution images. For Papoulis -Gerchberg method number of iterations and the filter used both

  15. The SuperNova Early Warning System

    OpenAIRE

    Scholberg, K.

    2008-01-01

    A core collapse in the Milky Way will produce an enormous burst of neutrinos in detectors world-wide. Such a burst has the potential to provide an early warning of a supernova's appearance. I will describe the nature of the signal, the sensitivity of current detectors, and SNEWS, the SuperNova Early Warning System, a network designed to alert astronomers as soon as possible after the detected neutrino signal.

  16. (Super-)renormalizably dressed black holes

    OpenAIRE

    Ayón-Beato, Eloy; Hassaïne, Mokhtar; Méndez-Zavaleta, Julio A.

    2015-01-01

    Black holes supported by self-interacting conformal scalar fields can be considered as renormalizably dressed since the conformal potential is nothing but the top power-counting renormalizable self-interaction in the relevant dimension. On the other hand, potentials defined by powers which are lower than the conformal one are also phenomenologically relevant since they are in fact super-renormalizable. In this work we provide a new map that allows to build black holes dressed with all the (su...

  17. Dating With Super Junior-M

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    担心情人节没人陪?还在幻想能与谁约会?2009年2月14日,梦想照进现实,SJ-M将在上海举办“情人Superman-Super Junior-M 2009上海歌会”,化身你的甜蜜情人,与你一起共度浪漫情人节。

  18. Super-Kamiokande - Present and Future

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Y. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Higashi-Mozumi, Kamioka-chou, Hida-city, Gifu 506-1205 (Japan)

    2004-12-15

    We summarize the latest results on the atmospheric and solar neutrinos from Super-Kamiokande. The atmospheric neutrino oscillation analyses with two flavors and with three flavor are discussed and the new results based on the L/E analysis are shown. New solar neutrino results based on the un-binned method is discussed. The current status of SK-II and the future prospects for SK neutrino oscillation experiment are summarized.

  19. The (Super)String Theories' Problems

    CERN Document Server

    Naboulsi, R

    2003-01-01

    (Super)String theories are theoretical ideas that go beyond the standard model of particle and high energy physics and show promise for unifying all forces in nature including the gravitational one. In this unification a prominent role is played by the duality symmetries which relate different theories. I present a review of these developements and discuss their problems and possible impact in low-energy physics. We explain and discuss some ideas concerning string field theories from noncommutative geometry.

  20. T-Duality from super Lie n-algebra cocycles for super p-branes

    CERN Document Server

    Fiorenza, Domenico; Schreiber, Urs

    2016-01-01

    We compute the $L_\\infty$-theoretic dimensional reduction of the F1/D$p$-brane super $L_\\infty$-cocycles with coefficients in rationalized twisted K-theory from the 10d type IIA and type IIB super Lie algebras down to 9d. We show that the two resulting coefficient $L_\\infty$-algebras are naturally related by an $L_\\infty$-isomorphism which we find to act on the super $p$-brane cocycles by the infinitesimal version of the rules of topological T-duality and inducing an isomorphism between $K^0$ and $K^1$, rationally. Moreover, we show that these $L_\\infty$-algebras are the homotopy quotients of the RR-charge coefficients by the "T-duality Lie 2-algebra". We find that the induced $L_\\infty$-extension is a gerby extension of a 9+(1+1) dimensional (i.e. "doubled") T-duality correspondence super-spacetime, which serves as a local model for T-folds. We observe that this still extends, via the D0-brane cocycle of its type IIA factor, to a 10+(1+1)-dimensional super Lie algebra. Finally we observe that this satisfies ...

  1. SuperB Progress Reports - Physics

    CERN Document Server

    O'Leary, B.; Ramon, M.; Pous, E.; De Fazio, F.; Palano, A.; Eigen, G.; Asgeirsson, D.; Cheng, C.H.; Chivukula, A.; Echenard, B.; Hitlin, D.G.; Porter, F.; Rakitin, A.; Heinemeyer, S.; McElrath, B.; Andreassen, R.; Meadows, B.; Sokoloff, M.; Blanke, M.; Lesiak, T.; Shindou, T.; Ronga, F.; Baldini, W.; Bettoni, D.; Calabrese, R.; Cibinetto, G.; Luppi, E.; Rama, M.; Bossi, F.; Guido, E.; Patrignani, C.; Tosi, S.; Davies, C.; Lunghi, E.; Haisch, U.; Hurth, T.; Westhoff, S.; Crivellin, A.; Hofer, L.; Goto, T.; Brown, David Nathan; Branco, G.C.; Zupan, J.; Herrero, M.; Rodriguez-Sanchez, A.; Simi, G.; Tackmann, F.J.; Biassoni, P.; Lazzaro, A.; Lombardo, V.; Palombo, F.; Stracka, S.; Lindemann, D.M.; Robertson, S.H.; Duling, B.; Gemmler, K.; Gorbahn, M.; Jager, S.; Paradisi, P.; Straub, D.M.; Bigi, I.; Asner, D.M.; Fast, J.E.; Kouzes, R.T.; Morandin, M.; Rotondo, M.; Ben-Haim, E.; Arnaud, N.; Burmistrov, L.; Kou, E.; Perez, A.; Stocchi, A.; Viaud, B.; Domingo, F.; Piccinini, F.; Manoni, E.; Batignani, G.; Cervelli, A.; Forti, F.; Giorgi, M.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Neri, N.; Walsh, J.; Bevan, A.; Bona, M.; Walker, C.; Weiland, C.; Lenz, A.; Gonzalez-Sprinberg, G.; Faccini, R.; Renga, F.; Polosa, A.; Silvestrini, L.; Virto, J.; Ciuchini, M.; Lubicz, V.; Tarantino, C.; Wilson, F.F.; Carpinelli, M.; Huber, T.; Mannel, T.; Graham, M.; Ratcliff, B.N.; Santoro, V.; Sekula, S.; Shougaev, K.; Soffer, A.; Shimizu, Y.; Gambino, P.; Mussa, R.; Nardecchia, M.; Stal, O.; Bernabeu, J.; Botella, F.; Jung, M.; Lopez March, N.; Martinez Vidal, F.; Oyanguren, A.; Pich, A.; Lozano, M.A.Sanchis; Vidal, J.; Vives, O.; Banerjee, S.; Roney, J.M.; Petrov, A.A.; Flood, K.

    2010-01-01

    SuperB is a high luminosity e+e- collider that will be able to indirectly probe new physics at energy scales far beyond the reach of any man made accelerator planned or in existence. Just as detailed understanding of the Standard Model of particle physics was developed from stringent constraints imposed by flavour changing processes between quarks, the detailed structure of any new physics is severely constrained by flavour processes. In order to elucidate this structure it is necessary to perform a number of complementary studies of a set of golden channels. With these measurements in hand, the pattern of deviations from the Standard Model behavior can be used as a test of the structure of new physics. If new physics is found at the LHC, then the many golden measurements from SuperB will help decode the subtle nature of the new physics. However if no new particles are found at the LHC, SuperB will be able to search for new physics at energy scales up to 10-100 TeV. In either scenario, flavour physics measure...

  2. The SuperNEMO tracking detector

    CERN Document Server

    Cascella, M

    2015-01-01

    The SuperNEMO detector will search for neutrinoless double beta decay at the Modane Underground Laboratory on the French-Italian border. This decay mode, if observed, would be proof that the neutrino is its own antiparticle, would constitute evidence for total lepton number violation, and could allow a measurement of the absolute neutrino mass. The SuperNEMO experiment is designed to reach a half-life sensitivity of $10^{26}$ years corresponding to an effective Majorana neutrino mass of $50-100~$meV. The SuperNEMO detector design allows complete topological reconstruction of the double beta decay event enabling excellent levels of background rejection. In the event of a discovery, such topological measurements will be vital in determining the nature of the lepton number violating process. This reconstruction will be performed by a gaseous tracking detector, consisting of 2034 drift cells per module operated in Geiger mode. The tracker of the Demonstrator Module is currently under construction in the UK. This ...

  3. SuperB Technical Design Report

    CERN Document Server

    Baszczyk, M; Kolodziej, J; Kucewicz, W; Sapor, M; Jeremie, A; Pous, E Grauges; Bruno, G E; De Robertis, G; Diacono, D; Donvito, G; Fusco, P; Gargano, F; Giordano, F; Loddo, F; Loparco, F; Maggi, G P; Manzari, V; Mazziotta, M N; Nappi, E; Palano, A; Santeramo, B; Sgura, I; Silvestris, L; Spinoso, V; Eigen, G; Zalieckas, J; Zhuo, Z; Jenkovszky, L; Balbi, G; Boldini, M; Bonacorsi, D; Cafaro, V; D'Antone, I; Dallavalle, G M; Di Sipio, R; Fabbri, F; Fabbri, L; Gabrielli, A; Galli, D; Giacomelli, P; Giordano, V; Giorgi, F M; Grandi, C; Lax, I; Meo, S Lo; Marconi, U; Montanari, A; Pellegrini, G; Piccinini, M; Rovelli, T; Cesari, N Semprini; Torromeo, G; Tosi, N; Travaglini, R; Vagnoni, V M; Valentinetti, S; Villa, M; Zoccoli, A; Caron, J -F; Hearty, C; Lu, P F -T; Mattison, T S; McKenna, J A; So, R Y -C; Barnyakov, M Yu; Blinov, V E; Botov, A A; Druzhinin, V P; Golubev, V B; Kononov, S A; Kravchenko, E A; Levichev, E B; Onuchin, A P; Serednyakov, S I; Shtol, D A; Skovpen, Y I; Solodov, E P; Cardini, A; Carpinelli, M; Chao, D S -T; Cheng, C H; Doll, D A; Echenard, B; Flood, K; Hanson, J; Hitlin, D G; Ongmongkolkul, P; Porter, F C; Zhu, R Y; Randazzo, N; Burelo, E De La Cruz; Zheng, Y; Campos, P; De Silva, M; Kathirgamaraju, A; Meadows, B; Pushpawela, B; Shi, Y; Sokoloff, M; Castro, G Lopez; Ciaschini, V; Franchini, P; Giacomini, F; Paolini, A; Polania, G A Calderon; Laczek, S; Romanowicz, P; Szybinski, B; Czuchry, M; Flis, L; Harezlak, D; Kocot, J; Radecki, M; Sterzel, M; Szepieniec, T; Szymocha, T; Wójcik, P; Andreotti, M; Baldini, W; Calabrese, R; Carassiti, V; Cibinetto, G; Ramusino, A Cotta; Evangelisti, F; Gianoli, A; Luppi, E; Malaguti, R; Manzali, M; Melchiorri, M; Munerato, M; Padoan, C; Santoro, V; Tomassetti, L; Beretta, M M; Biagini, M; Boscolo, M; Capitolo, E; de Sangro, R; Esposito, M; Felici, G; Finocchiaro, G; Gatta, M; Gatti, C; Guiducci, S; Lauciani, S; Patteri, P; Peruzzi, I; Piccolo, M; Raimondi, P; Rama, M; Sanelli, C; Tomassini, S; Fabbricatore, P; Delepine, D; Santos, M A Reyes; Chrzaszcz, M; Grzymkowski, R; Knap, P; Kotula, J; Lesiak, T; Ludwin, J; Michalowski, J; Pawlik, B; Rachwal, B; Stodulski, M; Wiechczynski, J; Witek, M; Zawiejski, L; Zdybal, M; Aushev, V Y; Ustynov, A; Arnaud, N; Bambade, P; Beigbeder, C; Bogard, F; Borsato, M; Breton, D; Brossard, J; Burmistrov, L; Charlet, D; Chaumat, V; Dadoun, O; Berni, M El; Maalmi, J; Puill, V; Rimbault, C; Stocchi, A; Tocut, V; Variola, A; Wallon, S; Wormser, G; Grancagnolo, F; Ben-Haim, E; Sitt, S; Baylac, M; Bourrion, O; Deconto, J -M; Martinez, Y Gomez; Monseu, N; Muraz, J -F; Real, J -S; Vescovi, C; Cenci, R; Jawahery, A; Roberts, D; Twedt, E W; Cheaib, R; Lindemann, D; Nderitu, S; Patel, P; Robertson, S H; Swersky, D; Warburton, A; Flores, E Cuautle; Sanchez, G Toledo; Biassoni, P; Bombelli, L; Citterio, M; Coelli, S; Fiorini, C; Liberali, V; Monti, M; Nasri, B; Neri, N; Palombo, F; Sabatini, F; Stabile, A; Berra, A; Giachero, A; Gotti, C; Lietti, D; Maino, M; Pessina, G; Prest, M; Martin, J -P; Simard, M; Starinski, N; Taras, P; Drutskoy, A; Makarychev, S; Nefediev, A V; Aloisio, A; Cavaliere, S; De Nardo, G; Della Pietra, M; Doria, A; Giordano, R; Ordine, A; Pardi, S; Russo, G; Sciacca, C; Bigi, I I; Jessop, C P; Wang, W; Bellato, M; Benettoni, M; Corvo, M; Crescente, A; Corso, F Dal; Dosselli, U; Fanin, C; Gianelle, A; Longo, S; Michelotto, M; Montecassiano, F; Morandin, M; Pengo, R; Posocco, M; Rotondo, M; Simi, G; Stroili, R; Gaioni, L; Manazza, A; Manghisoni, M; Ratti, L; Re, V; Traversi, G; Zucca, S; Bizzaglia, S; Bizzarri, M; Cecchi, C; Germani, S; Lebeau, M; Lubrano, P; Manoni, E; Papi, A; Rossi, A; Scolieri, G; Batignani, G; Bettarini, S; Casarosa, G; Cervelli, A; Fella, A; Forti, F; Giorgi, M; Lilli, L; Lusiani, A; Oberhof, B; Paladino, A; Pantaleo, F; Paoloni, E; Perez, A L Perez; Rizzo, G; Walsh, J; Téllez, A Fernández; Beck, G; Berman, M; Bevan, A; Gannaway, F; Inguglia, G; Martin, A J; Morris, J; Bocci, V; Capodiferro, M; Chiodi, G; Dafinei, I; Drenska, N V; Faccini, R; Ferroni, F; Gargiulo, C; Gauzzi, P; Luci, C; Lunadei, R; Martellotti, G; Pellegrino, F; Pettinacci, V; Pinci, D; Recchia, L; Ruggeri, D; Zullo, A; Camarri, P; Cardarelli, R; De Santis, C; Di Ciaccio, A; Di Felice, V; Di Palma, F; Di Simone, A; Marcelli, L; Messi, R; Moricciani, D; Sparvoli, R; Tammaro, S; Branchini, P; Budano, A; Bussino, S; Ciuchini, M; Nguyen, F; Passeri, A; Ruggieri, F; Spiriti, E; Wilson, F; Monzon, I Leon; Millan-Almaraz, J R; Podesta-Lerma, P L M; Aston, D; Dey, B; Fisher, A; Jackson, P D; Leith, D W G S; Luitz, S; MacFarlane, D; McCulloch, M; Metcalfe, S; Novokhatski, A; Osier, S; Prepost, R; Ratcliff, B; Seeman, J; Sullivan, M; Va'vra, J; Wienands, U; Wisniewski, W; Altschul, B D; Purohit, M V; Baudot, J; Ripp-Baudot, I; Cirrone, G A P; Cuttone, G; Bezshyyko, O; Dolinska, G; Soffer, A; Bianchi, F; De Mori, F; Filippi, A; Gamba, D; Marcello, S; Bomben, M; Bosisio, L; Cristaudo, P; Lanceri, L; Liberti, B; Rashevskaya, I; Stella, C; Vallazza, E S; Vitale, L; Auriemma, G; Satriano, C; Vidal, F Martinez; de Cos, J Mazorra; Oyanguren, A; Valls, P Ruiz; Beaulieu, A; Dejong, S; Franta, J; Lewczuk, M J; Roney, M; Sobie, R

    2013-01-01

    In this Technical Design Report (TDR) we describe the SuperB detector that was to be installed on the SuperB e+e- high luminosity collider. The SuperB asymmetric collider, which was to be constructed on the Tor Vergata campus near the INFN Frascati National Laboratory, was designed to operate both at the Upsilon(4S) center-of-mass energy with a luminosity of 10^{36} cm^{-2}s^{-1} and at the tau/charm production threshold with a luminosity of 10^{35} cm^{-2}s^{-1}. This high luminosity, producing a data sample about a factor 100 larger than present B Factories, would allow investigation of new physics effects in rare decays, CP Violation and Lepton Flavour Violation. This document details the detector design presented in the Conceptual Design Report (CDR) in 2007. The R&D and engineering studies performed to arrive at the full detector design are described, and an updated cost estimate is presented. A combination of a more realistic cost estimates and the unavailability of funds due of the global economic ...

  4. Predicting the occurrence of super-storms

    Directory of Open Access Journals (Sweden)

    N. Srivastava

    2005-11-01

    Full Text Available A comparative study of five super-storms (Dst<-300 nT of the current solar cycle after the launch of SoHO, to identify solar and interplanetary variables that influence the magnitude of resulting geomagnetic storms, is described. Amongst solar variables, the initial speed of a CME is considered the most reliable predictor of the strength of the associated geomagnetic storm because fast mass ejections are responsible for building up the ram pressure at the Earth's magnetosphere. However, although most of the super-storms studied were associated with high speed CMEs, the Dst index of the resulting geomagnetic storms varied between -300 to -472 nT. The most intense storm of 20 November 2003, (Dst ~ -472 nT had its source in a comparatively smaller active region and was associated with a relatively weaker, M-class flare while all other super-storms had their origins in large active regions and were associated with strong X-class flares. However, this superstorm did not show any associated extraordinary solar and interplanetary characteristics. The study also reveals the challenge in the reliable prediction of the magnitude of a geomagnetic storm from solar and interplanetary variables.

  5. GOLD and the fixed ratio

    Directory of Open Access Journals (Sweden)

    Vestbo J

    2012-09-01

    Full Text Available Jørgen VestboUniversity of Manchester, Manchester, UKI read with interest the paper entitled "Diagnosis of airway obstruction in the elderly: contribution of the SARA study" by Sorino et al in a recent issue of this journal.1 Being involved in the Global Initiative for Obstructive Lung Diseases (GOLD, it is nice to see the interest sparked by the GOLD strategy document. However, in the paper by Sorino et al, there are a few misunderstandings around GOLD and the fixed ratio (forced expiratory volume in 1 second/forced volume vital capacity < 0.70 that need clarification.View original paper by Sorino and colleagues.

  6. Virtualizing Super-Computation On-Board Uas

    Science.gov (United States)

    Salami, E.; Soler, J. A.; Cuadrado, R.; Barrado, C.; Pastor, E.

    2015-04-01

    Unmanned aerial systems (UAS, also known as UAV, RPAS or drones) have a great potential to support a wide variety of aerial remote sensing applications. Most UAS work by acquiring data using on-board sensors for later post-processing. Some require the data gathered to be downlinked to the ground in real-time. However, depending on the volume of data and the cost of the communications, this later option is not sustainable in the long term. This paper develops the concept of virtualizing super-computation on-board UAS, as a method to ease the operation by facilitating the downlink of high-level information products instead of raw data. Exploiting recent developments in miniaturized multi-core devices is the way to speed-up on-board computation. This hardware shall satisfy size, power and weight constraints. Several technologies are appearing with promising results for high performance computing on unmanned platforms, such as the 36 cores of the TILE-Gx36 by Tilera (now EZchip) or the 64 cores of the Epiphany-IV by Adapteva. The strategy for virtualizing super-computation on-board includes the benchmarking for hardware selection, the software architecture and the communications aware design. A parallelization strategy is given for the 36-core TILE-Gx36 for a UAS in a fire mission or in similar target-detection applications. The results are obtained for payload image processing algorithms and determine in real-time the data snapshot to gather and transfer to ground according to the needs of the mission, the processing time, and consumed watts.

  7. Mapping ionospheric backscatter measured by the SuperDARN HF radars – Part 1: A new empirical virtual height model

    Directory of Open Access Journals (Sweden)

    T. K. Yeoman

    2008-05-01

    Full Text Available Accurately mapping the location of ionospheric backscatter targets (density irregularities identified by the Super Dual Auroral Radar Network (SuperDARN HF radars can be a major problem, particularly at far ranges for which the radio propagation paths are longer and more uncertain. Assessing and increasing the accuracy of the mapping of scattering locations is crucial for the measurement of two-dimensional velocity structures on the small and meso-scale, for which overlapping velocity measurements from two radars need to be combined, and for studies in which SuperDARN data are used in conjunction with measurements from other instruments. The co-ordinates of scattering locations are presently estimated using a combination of the measured range and a model virtual height, assuming a straight line virtual propagation path. By studying elevation angle of arrival information of backscatterred signals from 5 years of data (1997–2001 from the Saskatoon SuperDARN radar we have determined the actual distribution of the backscatter target locations in range-virtual height space. This has allowed the derivation of a new empirical virtual height model that allows for a more accurate mapping of the locations of backscatter targets.

  8. MTF Measurement of EBCCD Imaging System by Using Super Resolution Technique

    Institute of Scientific and Technical Information of China (English)

    左昉; 高岳; 高稚允; 苏美开; 周立伟

    2003-01-01

    Existing methods of measurement MTF for discrete imaging system are analysed. A slit target is frequently used to measure the MTF for an imaging system. Usually there are four methods to measure the MTF for a discrete imaging system by using a slit. These methods have something imperfect respectively. But for the discrete imaging systems of under sampling it is difficult to reproduce this type of target properly since frequencies above Nyquist are folded into those below Nyquist, resulting in aliasing effect. To tackle the aliasing problem, a super resolution technique is introduced into our measurement, which gives MTF values both above and below Nyquist more accurately.

  9. Homotopies and the Universal Fixed Point Property

    DEFF Research Database (Denmark)

    Szymik, Markus

    2015-01-01

    A topological space has the fixed point property if every continuous self-map of that space has at least one fixed point. We demonstrate that there are serious restraints imposed by the requirement that there be a choice of fixed points that is continuous whenever the self-map varies continuously...

  10. Utilization of nitrogen fixing trees

    Energy Technology Data Exchange (ETDEWEB)

    Brewbaker, J.L.; Beldt, R. van den; MacDicken, K.; Budowski, G.; Kass, D.C.L.; Russo, R.O.; Escalante, G.; Herrera, R.; Aranguren, J.; Arkcoll, D.B.; Doebereinger, J. (cord.)

    1983-01-01

    Six papers from the symposium are noted. Brewbaker, J.L., Beldt, R. van den, MacDicken, K. Fuelwood uses and properties of nitrogen-fixing trees, pp 193-204, (Refs. 15). Includes a list of 35 nitrogen-fixing trees of high fuelwood value. Budowski, G.; Kass, D.C.L.; Russo, R.O. Leguminous trees for shade, pp 205-222, (Refs. 68). Escalante, G., Herrera, R., Aranguren, J.; Nitrogen fixation in shade trees (Erythrina poeppigiana) in cocoa plantations in northern Venezuela, pp 223-230, (Refs. 13). Arkcoll, D.B.; Some leguminous trees providing useful fruits in the North of Brazil, pp 235-239, (Refs. 13). This paper deals with Parkia platycephala, Pentaclethra macroloba, Swartzia sp., Cassia leiandra, Hymenaea courbaril, dipteryz odorata, Inga edulis, I. macrophylla, and I. cinnamonea. Baggio, A.J.; Possibilities of the use of Gliricidia sepium in agroforestry systems in Brazil, pp 241-243; (Refs. 15). Seiffert, N.F.; Biological nitrogen and protein production of Leucaena cultivars grown to supplement the nutrition of ruminants, pp 245-249, (Refs. 14). Leucaena leucocephala cv. Peru, L. campina grande (L. leucocephala), and L. cunningham (L. leucocephalae) were promising for use as browse by beef cattle in central Brazil.

  11. Measurement of the principal values of the chemical-shift tensors of overlapping protonated and unprotonated carbons with the 2D-SUPER technique and dipolar dephasing (DD-SUPER)

    Science.gov (United States)

    Liu, Wei; Wang, Wei D.; Wang, Wei; Bai, Shi; Dybowski, Cecil

    2010-09-01

    A modified 2D-SUPER technique is demonstrated to allow independent measurement of the principal values of the chemical-shift tensors of overlapping protonated and unprotonated carbons. The insertion of a dipolar-dephasing period into the sequence causes loss of signal from protonated carbons. The spectrum obtained with this modification allows one to determine the principal values of the unprotonated carbons with high precision. Subsequent fitting of the usual 2D-SUPER spectrum, with the chemical-shift parameters of the unprotonated carbons fixed, gives the parameters of the overlapped resonances of the protonated carbons. As an example, we report the determination of the 13C chemical-shift parameters of the carbons of form II of piroxicam. The experimental results are compared with those obtained from calculations using the DFT/GIAO method. Potential applications of this method are discussed.

  12. Super-Resolution Imaging on Microfluidic Super-Resolution Near-Field Structure

    Institute of Scientific and Technical Information of China (English)

    WANG Pei; TANG Lin; ZHANG Dou-Guo; LU Yong-Hua; JIAO Xiao-Jin; XIE Jian-Ping; MING Hai

    2005-01-01

    @@ We present a new concept of the microfluidic super-resolution near-field structure (MSRENS) based on a microfluidic structure and a super-resolution near-field structure. The near-field distance control, "nano-probe"and scanning can be realized simultaneously using the MSRENS, which is similar to a near-field scanning optical microscope. The design and simulation results are presented. Numerical simulation has demonstrated that the MSRENS with spatial resolution beyond the diffraction limit could be applicable in chemistry, biologics, and many other fields.

  13. SuperB: An opportunity to study baryons with beauty and bottom super-nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Feliciello, A., E-mail: Alessandro.Feliciello@to.infn.it [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, Via P. Giuria 1, I-10125 Torino (Italy)

    2012-05-01

    SuperB is an INFN flagship project for a new high-luminosity heavy-flavor factory. Along with its companion detector, it is dedicated to the search for CP violation effects in the B meson sector with the aim of looking for direct and indirect signals of new physics, beyond the Standard Model. However it could offer as well the opportunity for a systematic, high-statistics study of b baryon properties and for a search for bottom super-nuclei, that is bound nuclear systems with an explicit content of beauty.

  14. RESEARCH NOTES On the support of super-Brownian motion with super-Brownian immigration

    Institute of Scientific and Technical Information of China (English)

    洪文明; 钟惠芳

    2001-01-01

    The support properties of the super Brownian motion with random immigration Xρ1 are considered,where the immigration rate is governed by the trajectory of another super-Brownian motion ρ. When both the initial state Xρo of the process and the immigration rate process ρo are of finite measure and with compact supports, the probability of the support of the process Xρi dominated by a ball is given by the solutions of a singular elliptic boundary value problem.

  15. Super-hybrid composites - An emerging structural material

    Science.gov (United States)

    Chamis, C. C.; Lark, R. F.; Sullivan, T. L.

    1975-01-01

    Specimens of super-hybrids and advanced fiber composites were subjected to extensive tests to determine their mechanical properties, including impact and thermal fatigue. The super-hybrids were fabricated by a procedure similar to that reported by Chamis et al., (1975). Super-hybrids subjected to 1000 cycles of thermal fatigue from -100 to 300 F retained over 90% of their longitudinal flexural strength and over 75% of their transverse flexural strength; their transverse flexural strength may be as high as 8 times that of a commercially supplied boron/1100-Al composite. The thin specimen Izod longitudinal impact resistance of the super-hybrids was twice that of the boron/110-Al material. Super-hybrids subjected to transverse tensile loads exhibited nonlinear stress-strain relationships. The experimentally determined initial membrane (in-plane) and bending elastic properties of super-hybrids were predicted adequately by linear laminate analysis.

  16. Fixed Dose Combination for TB treatment

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2003-06-01

    Full Text Available According to the World Health Organization, a third of the world’s population is infected with tuberculosis. The disease is responsible for nearly 2 million deaths each year and over 8 million were developing active diseases. Moreover, according to WHO (2000, tuberculosis deaths are estimated to increase to 35 million between 2000-2020. The majority of tuberculosis patients worldwide are still treated with single drugs, or with 2-drug fixed-dose combinations (FDCs. To improve tuberculosis treatment, 2- and 3-drug FDCs were recommended by the World Health Organization (WHO as part of the DOTS strategy. Since 1999 a 4-drug FDC was included on the WHO Model List of Essential Drugs. Today, FDCs are important tools to further improve the quality of care for people with TB, and accelerate DOTS expansion to reach the global TB control targets. Fixed dose combination TB drugs could simplifies both treatment and management of drug supply, and may prevent the emergence of drug resistance .Prevention of drug resistance is just one of the potential benefits of the use of FDCs. FDCs simplify administration of drugs by reducing the number of pills a patient takes each day and decreasing the risk of incorrect prescriptions. Most tuberculosis patients need only take 3–4 FDCs tablets per day during the intensive phase of treatment, instead of the 15–16 tablets per day that is common with single-drug formulations It is much simpler to explain to patients that they need to take four tablets of the same type and colour, rather than a mixture of tablets of different shapes, colours and sizes. Also, the chance of taking an incomplete combination of drugs is eliminated, since the four essential drugs are combined into one tablet. FDCs are also simpler for care-givers as they minimize the risk of confusion. Finally, drug procurement, in all its components (stock management, shipping, distribution, is simplified by FDCs. Adverse reactions to drugs are not more

  17. SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation.

    Science.gov (United States)

    Takemoto, Kiwamu; Matsuda, Tomoki; Sakai, Naoki; Fu, Donald; Noda, Masanori; Uchiyama, Susumu; Kotera, Ippei; Arai, Yoshiyuki; Horiuchi, Masataka; Fukui, Kiichi; Ayabe, Tokiyoshi; Inagaki, Fuyuhiko; Suzuki, Hiroshi; Nagai, Takeharu

    2013-01-01

    Chromophore-assisted light inactivation (CALI) is a powerful technique for acute perturbation of biomolecules in a spatio-temporally defined manner in living specimen with reactive oxygen species (ROS). Whereas a chemical photosensitizer including fluorescein must be added to specimens exogenously and cannot be restricted to particular cells or sub-cellular compartments, a genetically-encoded photosensitizer, KillerRed, can be controlled in its expression by tissue specific promoters or subcellular localization tags. Despite of this superiority, KillerRed hasn't yet become a versatile tool because its dimerization tendency prevents fusion with proteins of interest. Here, we report the development of monomeric variant of KillerRed (SuperNova) by direct evolution using random mutagenesis. In contrast to KillerRed, SuperNova in fusion with target proteins shows proper localization. Furthermore, unlike KillerRed, SuperNova expression alone doesn't perturb mitotic cell division. Supernova retains the ability to generate ROS, and hence promote CALI-based functional analysis of target proteins overcoming the major drawbacks of KillerRed.

  18. On Super Edge-Antimagicness of Subdivided Stars

    Directory of Open Access Journals (Sweden)

    Raheem A.

    2015-11-01

    Full Text Available Enomoto, Llado, Nakamigawa and Ringel (1998 defined the concept of a super (a, 0-edge-antimagic total labeling and proposed the conjecture that every tree is a super (a, 0-edge-antimagic total graph. In the support of this conjecture, the present paper deals with different results on super (a, d-edge-antimagic total labeling of subdivided stars for d ∈ {0, 1, 2, 3}.

  19. The Robotic Super-LOTIS Telescope: Results & Future Plans

    OpenAIRE

    Williams, G. G.; Milne, P. A.; Park, H.S.; Barthelmy, S. D.; Hartmann, D. H.; Updike, A.; Hurley, K.

    2008-01-01

    We provide an overview of the robotic Super-LOTIS (Livermore Optical Transient Imaging System) telescope and present results from gamma-ray burst (GRB) afterglow observations using Super-LOTIS and other Steward Observatory telescopes. The 0.6-m Super-LOTIS telescope is a fully robotic system dedicated to the measurement of prompt and early time optical emission from GRBs. The system began routine operations from its Steward Observatory site atop Kitt Peak in April 2000 and currently operates ...

  20. Editorial: Using charcoal to fix the price of carbon emissions

    Directory of Open Access Journals (Sweden)

    Nicholas Gray

    2009-12-01

    Full Text Available Using charcoal as a model is probably as close as we can come at present to developing a realistic cost for offsetting CO2 emissions. Of course, carbon taxation needs an equitable basis for calculation and, unlike the current offset costs that are based largely on what the voluntary market can sustain, fixed emission charges per weight may well be the incentive required to achieve elusive GHG reduction targets.

  1. Super-enhancer lncs to cardiovascular development and disease.

    Science.gov (United States)

    Ounzain, Samir; Pedrazzini, Thierry

    2016-07-01

    Cardiac development, function and pathological remodelling in response to stress depend on the dynamic control of tissue specific gene expression by distant acting transcriptional enhancers. Recently, super-enhancers (SEs), also known as stretch or large enhancer clusters, are emerging as sentinel regulators within the gene regulatory networks that underpin cellular functions. It is becoming increasingly evident that long noncoding RNAs (lncRNAs) associated with these sequences play fundamental roles for enhancer activity and the regulation of the gene programs hardwired by them. Here, we review this emerging landscape, focusing on the roles of SEs and their derived lncRNAs in cardiovascular development and disease. We propose that exploration of this genomic landscape could provide novel therapeutic targets and approaches for the amelioration of cardiovascular disease. Ultimately we envisage a future of ncRNA therapeutics targeting the SE landscape to alleviate cardiovascular disease. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

  2. Relativistic nonlinear electrodynamics the QED vacuum and matter in super-strong radiation fields

    CERN Document Server

    Avetissian, Hamlet K

    2016-01-01

    This revised edition of the author’s classic 2006 text offers a comprehensively updated review of the field of relativistic nonlinear electrodynamics. It explores the interaction of strong and super-strong electromagnetic/laser radiation with the electromagnetic quantum vacuum and diverse types of matter – including free charged particles and antiparticles, acceleration beams, plasma and plasmous media.  The appearance of laser sources of relativistic and ultra-relativistic intensities over the last decade has stimulated investigation of a large class of processes under such super-strong radiation fields. Revisions for this second edition reflect these developments and the book includes new chapters on Bremsstrahlung and nonlinear absorption of superintense radiation in plasmas, the nonlinear interaction of relativistic atoms with intense laser radiation, nonlinear interaction of strong laser radiation with Graphene, and relativistic nonlinear phenomena in solid-plasma targets under supershort laser pul...

  3. Spin groups of super metrics and a theorem of Rogers

    Science.gov (United States)

    Fulp, Ronald

    2017-01-01

    We derive the canonical forms of super Riemannian metrics and the local isometry groups of such metrics. For certain super metrics we also compute the simply connected covering groups of the local isometry groups and interpret these as local spin groups of the super metric. Super metrics define reductions OSg of the relevant frame bundle. When principal bundles S˜g exist with structure group the simply connected covering group G ˜ of the structure group of OSg , representations of G ˜ define vector bundles associated to S˜g whose sections are "spinor fields" associated with the super metric g . Using a generalization of a Theorem of Rogers, which is itself one of the main results of this paper, we show that for super metrics we call body reducible, each such simply connected covering group G ˜ is a super Lie group with a conventional super Lie algebra as its corresponding super Lie algebra. Some of our results were known to DeWitt (1984) using formal Grassmann series and others were known by Rogers using finitely many Grassmann generators and passing to a direct limit. We work exclusively in the category of G∞ supermanifolds with G∞ mappings. Our supernumbers are infinite series of products of Grassmann generators subject to convergence in the ℓ1 norm introduced by Rogers (1980, 2007).

  4. New Results from Super-K and K2K

    CERN Document Server

    Wilkes, R J

    2002-01-01

    This paper summarizes recent (as of SSI-02, in some cases updated in November, 2002) results from the Super-Kamiokande and K2K experiments. The interpretation of Super-Kamiokande results on atmospheric and solar neutrinos provides strong evidence for neutrino oscillations, hence non-zero neutrino mass. While statistics are still limited, K2K data are consistent with Super-Kamiokande results on neutrino oscillations. The effort to reconstruct Super-Kamiokande following a cascade of phototube implosions in November, 2001 is described. Plans for the future are also discussed.

  5. Video super-resolution using simultaneous motion and intensity calculations

    DEFF Research Database (Denmark)

    Keller, Sune Høgild; Lauze, Francois Bernard; Nielsen, Mads

    2011-01-01

    for the joint estimation of a super-resolution sequence and its flow field. Via the calculus of variations, this leads to a coupled system of partial differential equations for image sequence and motion estimation. We solve a simplified form of this system and as a by-product we indeed provide a motion field...... for super-resolved sequences. Computing super-resolved flows has to our knowledge not been done before. Most advanced super-resolution (SR) methods found in literature cannot be applied to general video with arbitrary scene content and/or arbitrary optical flows, as it is possible with our simultaneous VSR...

  6. Complex issues in accounting for fixed assets

    Directory of Open Access Journals (Sweden)

    Mykhaylo Luchko

    2013-11-01

    Full Text Available This paper considers the mentioned complex issues of business fixed assets accounting. The main emphasis in this case refers to the change in value of fixed assets over time. Author studied problems of the regulatory revaluation of fixed assets in accordance with the applicable accounting standards (regulations. Particular attention is paid to the revaluation and impairment of the business fixed assets objects and their recording on accounts. Author analyzed the complex issues in establishing the fair value of fixed assets. Attention is focused on the harmonization of accounting information with tax calculations and reporting provided by the Ukrainian Tax Code. In considering the matter referred to the tax differences (temporary and permanent. Established tax differences in depreciation of fixed assets, impairment amounts and revaluation of fixed assets and accounting entries to them.

  7. Simple fixed functional space maintainer.

    Science.gov (United States)

    Goenka, Puneet; Sarawgi, Aditi; Marwah, Nikhil; Gumber, Parvind; Dutta, Samir

    2014-01-01

    Premature loss of a primary tooth is one of the most common etiology for malocclusion. Space maintainers are employed to prevent this complication. In anterior region, esthetics is an important concern along with function and space management. Fiber-reinforced composite (FRC) retained space maintainer solves all these purposes ef ficiently and ef fectively. In addition, the technique is simple and the appliance is very comfortable inside the oral cavity. Here is a case of premature loss of anterior primary tooth which was replaced by FRC retained esthetic functional space maintainer. The appliance was found to be functioning satisfactorily inside the oral cavity till the last visit (1 Year). How to cite this article: Goenka P, Sarawgi A, Marwah N, Gumber P, Dutta S. Simple Fixed Functional Space Maintainer. Int J Clin Pediatr Dent 2014;7(3):225-228.

  8. Fixed Point and Aperiodic Tilings

    CERN Document Server

    Durand, Bruno; Shen, Alexander

    2008-01-01

    An aperiodic tile set was first constructed by R.Berger while proving the undecidability of the domino problem. It turned out that aperiodic tile sets appear in many topics ranging from logic (the Entscheidungsproblem) to physics (quasicrystals) We present a new construction of an aperiodic tile set that is based on Kleene's fixed-point construction instead of geometric arguments. This construction is similar to J. von Neumann self-reproducing automata; similar ideas were also used by P. Gacs in the context of error-correcting computations. The flexibility of this construction allows us to construct a ``robust'' aperiodic tile set that does not have periodic (or close to periodic) tilings even if we allow some (sparse enough) tiling errors. This property was not known for any of the existing aperiodic tile sets.

  9. Super-Hamiltonian Structures and Conservation Laws of a New Six-Component Super-Ablowitz-Kaup-Newell-Segur Hierarchy

    Directory of Open Access Journals (Sweden)

    Fucai You

    2014-01-01

    Full Text Available A six-component super-Ablowitz-Kaup-Newell-Segur (-AKNS hierarchy is proposed by the zero curvature equation associated with Lie superalgebras. Supertrace identity is used to furnish the super-Hamiltonian structures for the resulting nonlinear superintegrable hierarchy. Furthermore, we derive the infinite conservation laws of the first two nonlinear super-AKNS equations in the hierarchy by utilizing spectral parameter expansions. PACS: 02.30.Ik; 02.30.Jr; 02.20.Sv.

  10. Super-Liouville - Double Liouville correspondence

    CERN Document Server

    Hadasz, Leszek

    2014-01-01

    The AGT motivated relation between the tensor product of the N=1 super-Liouville field theory with the imaginary free fermion (SL) and a certain projected tensor products of the real and the imaginary Liouville field theories (LL) is analyzed. Using conformal field theory techniques we give a complete proof of the equivalence in the NS sector. It is shown that SL-LL correspondence is based on the equivalence of chiral objects including suitably chosen chiral structure constants of all three Liouville theories involved.

  11. A Trio of Super-Earths

    Science.gov (United States)

    2008-06-01

    Today, at an international conference, a team of European astronomers announced a remarkable breakthrough in the field of extra-solar planets. Using the HARPS instrument at the ESO La Silla Observatory, they have found a triple system of super-Earths around the star HD 40307. Moreover, looking at their entire sample studied with HARPS, the astronomers count a total of 45 candidate planets with a mass below 30 Earth masses and an orbital period shorter than 50 days. This implies that one solar-like star out of three harbours such planets. A trio of Super-Earths ESO PR Photo 19a/08 A trio of Super-Earths "Does every single star harbour planets and, if yes, how many?" wonders planet hunter Michel Mayor from Geneva Observatory. "We may not yet know the answer but we are making huge progress towards it." Since the discovery in 1995 of a planet around the star 51 Pegasi by Mayor and Didier Queloz, more than 270 exoplanets have been found, mostly around solar-like stars. Most of these planets are giants, such as Jupiter or Saturn, and current statistics show that about 1 out of 14 stars harbours this kind of planet. "With the advent of much more precise instruments such as the HARPS spectrograph on ESO's 3.6-m telescope at La Silla, we can now discover smaller planets, with masses between 2 and 10 times the Earth's mass," says Stéphane Udry, one of Mayor's colleagues. Such planets are called super-Earths, as they are more massive than the Earth but less massive than Uranus and Neptune (about 15 Earth masses). The group of astronomers have now discovered a system of three super-Earths around a rather normal star, which is slightly less massive than our Sun, and is located 42 light-years away towards the southern Doradus and Pictor constellations. "We have made very precise measurements of the velocity of the star HD 40307 over the last five years, which clearly reveal the presence of three planets," says Mayor. The planets, having 4.2, 6.7, and 9.4 times the mass of the

  12. SuperLU users' guide

    Energy Technology Data Exchange (ETDEWEB)

    Demmel, James W.; Gilbert, John R.; Li, Xiaoye S.

    1999-11-01

    This document describes a collection of three related ANSI C subroutine libraries for solving sparse linear systems of equations AX = B: Here A is a square, nonsingular, n x n sparse matrix, and X and B are dense n x nrhs matrices, where nrhs is the number of right-hand sides and solution vectors. Matrix A need not be symmetric or definite; indeed, SuperLU is particularly appropriate for matrices with very unsymmetric structure. All three libraries use variations of Gaussian elimination optimized to take advantage both of sparsity and the computer architecture, in particular memory hierarchies (caches) and parallelism.

  13. Production of super-smooth articles

    Energy Technology Data Exchange (ETDEWEB)

    Duchane, D.V.

    1981-05-29

    Super-smooth rounded or formed articles made of thermoplastic materials including various poly(methyl methacrylate) or acrylonitrile-butadiene-styrene copolymers are produced by immersing the articles into a bath, the composition of which is slowly changed with time. The starting composition of the bath is made up of at least one solvent for the polymer and a diluent made up of at least one nonsolvent for the polymer and optional materials which are soluble in the bath. The resulting extremely smooth articles are useful as mandrels for laser fusion and should be useful for a wide variety of other purposes, for example lenses.

  14. Emergent Super-Virasoro on Magnetic Branes

    CERN Document Server

    D'Hoker, Eric

    2016-01-01

    The low energy limit of the stress tensor, gauge current, and supercurrent two-point correlators are calculated in the background of the supersymmetric magnetic brane solution to gauged five-dimensional supergravity constructed by Almuhairi and Polchinski. The resulting correlators provide evidence for the emergence of an N=2 super-Virasoro algebra of right-movers, in addition to a bosonic Virasoro algebra and a $U(1) \\oplus U(1)$-current algebra of left-movers (or the parity transform of left- and right-movers depending on the sign of the magnetic field), in the holographically dual strongly interacting two-dimensional effective field theory of the lowest Landau level.

  15. Super-utilizers get red carpet treatment.

    Science.gov (United States)

    2014-01-01

    MetroHealth Medical Center in Cleveland has partnered with two health plans to provide intensive care coordination for high-cost patients with multiple medical problems and, often, behavioral health issues. Nurse practitioners at two primary care sites provide one-on-one care coordination for super-utilizers. They assess the patients' needs, help coordinate community resources, and prepare a treatment plan that is flagged when patients visit the emergency department. The nurse practitioners meet with health plan representatives monthly and brainstorm on ways to meet patients' needs.

  16. The Super-B Project Accelerator Status

    Energy Technology Data Exchange (ETDEWEB)

    Biagini, M.E.; Alesini, D.; Boni, R.; Boscolo, M.; Demma, T.; Drago, A.; Esposito, M.; Guiducci, S.; Marcellini, F.; Mazzitelli, G.; Preger, M.; Raimondi, P.; Sanelli, C.; Serio, M.; Stecchi, A.; Stella, A.; Tomassini, S.; Zobov, M.; /Frascati; Bertsche, K.; Brachmann, A.; Cai, Y.; /SLAC /Novosibirsk, IYF /Annecy, LAPP /LPSC, Grenoble /Orsay, LAL /Saclay /Pisa U. /CERN

    2011-08-17

    The SuperB project is an international effort aiming at building in Italy a very high luminosity e{sup +}e{sup -} (10{sup 36} cm{sup -2} sec{sup -1}) asymmetric collider at the Y(4S) energy in the CM. The accelerator design has been extensively studied and changed during the past year. The present design, based on the new collision scheme, with large Piwinski angle and the use of 'crab waist' sextupoles already successfully tested at the DA{Phi}NE {Phi}-Factory at LNF Frascati, provides larger flexibility, better dynamic aperture and spin manipulation sections in the Low Energy Ring (LER) for longitudinal polarization of the electron beam at the Interaction Point (IP). The Interaction Region (IR) has been further optimized in terms of apertures and reduced backgrounds in the detector. The injector complex design has been also updated. A summary of the project status will be presented in this paper. The SuperB collider can reach a peak luminosity of 10{sup 36} cm{sup -2} sec{sup -1} with beam currents and bunch lengths similar to those of the past and present e{sup +}e{sup -} Factories, through the use of smaller emittances and new scheme of crossing angle collision. The beams are stored in two rings at 6.7 GeV (HER) and 4.2 GeV (LER). Unique features of the project are the polarization of the electron beam in the LER and the possibility to decrease the energies for running at the {tau}/charm threshold. The option to reuse the PEP-II B-Factory (SLAC) hardware will allow reducing costs. The SuperB facility will require a big complex of civil infrastructure. The main construction, which will house the final part of the LINAC, the injection lines, the damping rings, and the storage rings, will be mainly underground. Two sites have been considered: the campus of Tor Vergata University near Frascati, and the INFN Frascati Laboratory. No decision has been made yet. A footprint of the possible SuperB layout on the LNF area is shown in Fig. 1.

  17. Super computer made with Linux cluster

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hun; Oh, Yeong Eun; Kim, Jeong Seok

    2002-01-15

    This book consists of twelve chapters, which introduce super computer made with Linux cluster. The contents of this book are Linux cluster, the principle of cluster, design of Linux cluster, general things for Linux, building up terminal server and client, Bear wolf cluster by Debian GNU/Linux, cluster system with red hat, Monitoring system, application programming-MPI, on set-up and install application programming-PVM, with PVM programming and XPVM application programming-open PBS with composition and install and set-up and GRID with GRID system, GSI, GRAM, MDS, its install and using of tool kit.

  18. Transfer function characteristics of super resolving systems

    Science.gov (United States)

    Milster, Tom D.; Curtis, Craig H.

    1992-01-01

    Signal quality in an optical storage device greatly depends on the optical system transfer function used to write and read data patterns. The problem is similar to analysis of scanning optical microscopes. Hopkins and Braat have analyzed write-once-read-many (WORM) optical data storage devices. Herein, transfer function analysis of magnetooptic (MO) data storage devices is discussed with respect to improving transfer-function characteristics. Several authors have described improving the transfer function as super resolution. However, none have thoroughly analyzed the MO optical system and effects of the medium. Both the optical system transfer function and effects of the medium of this development are discussed.

  19. Medical care at the Super Bowl.

    Science.gov (United States)

    Ellis, J M

    2000-06-01

    Although coordinating medical care at the Super Bowl is something that we look forward to and have a lot of fun doing, we take it very seriously and understand the importance of delivering medical care at what many people consider to be the greatest sporting event in the world. It is certainly one of the most watched and recognized events in the world and because of this, we attempt to set up a system that will allow for the best medical care available and standardization of this medical care through our experience within Medical Sports Group.

  20. Mid-IR super-continuum generation

    Science.gov (United States)

    Islam, Mohammed N.; Xia, Chenan; Freeman, Mike J.; Mauricio, Jeremiah; Zakel, Andy; Ke, Kevin; Xu, Zhao; Terry, Fred L., Jr.

    2009-02-01

    A Mid-InfraRed FIber Laser (MIRFIL) has been developed that generates super-continuum covering the spectral range from 0.8 to 4.5 microns with a time-averaged power as high as 10.5W. The MIRFIL is an all-fiber integrated laser with no moving parts and no mode-locked lasers that uses commercial off-the-shelf parts and leverages the mature telecom/fiber optics platform. The MIRFIL power can be easily scaled by changing the repetition rate and modifying the erbium-doped fiber amplifier. Some of the applications using the super-continuum laser will be described in defense, homeland security and healthcare. For example, the MIRFIL is being applied to a catheter-based medical diagnostic system to detect vulnerable plaque, which is responsible for most heart attacks resulting from hardening-of-the-arteries or atherosclerosis. More generally, the MIRFIL can be a platform for selective ablation of lipids without damaging normal protein or smooth muscle tissue.

  1. Review of Super Crunchers by Ian Ayers

    Directory of Open Access Journals (Sweden)

    Eric Gaze

    2009-07-01

    Full Text Available Ayers, I. Super Crunchers: Why Thinking-by-Numbers Is the New Way to be Smart. (Bantam Dell Publishing Group, 2007. 272 pp. Hard cover $25 ISBN 978-0-553-80540-6.Super Crunchers tells the story of how analyzing data is changing the ways in which decisions are made. We in the National Numeracy Network make a case for the importance of quantitative literacy by referring to how much quantitative information is now available to each of us: “a world awash in numbers.” Ian Ayres zeroes in on the people who are making a living crunching all of these data. From the seemingly innocuous (how wines are rated, and the scouting of baseball players to the life impacting (diagnosis of disease, and parole of inmates, this book paints a vivid portrayal of how data analysis is impacting decision making at every level in our society. The use of simple regression models and randomized trials is calling into question who the “experts” of the twenty-first century will be, and why thinking-by-numbers really is the new way to be smart.

  2. 3D super-virtual refraction interferometry

    KAUST Repository

    Lu, Kai

    2014-08-05

    Super-virtual refraction interferometry enhances the signal-to-noise ratio of far-offset refractions. However, when applied to 3D cases, traditional 2D SVI suffers because the stationary positions of the source-receiver pairs might be any place along the recording plane, not just along a receiver line. Moreover, the effect of enhancing the SNR can be limited because of the limitations in the number of survey lines, irregular line geometries, and azimuthal range of arrivals. We have developed a 3D SVI method to overcome these problems. By integrating along the source or receiver lines, the cross-correlation or the convolution result of a trace pair with the source or receiver at the stationary position can be calculated without the requirement of knowing the stationary locations. In addition, the amplitudes of the cross-correlation and convolution results are largely strengthened by integration, which is helpful to further enhance the SNR. In this paper, both synthetic and field data examples are presented, demonstrating that the super-virtual refractions generated by our method have accurate traveltimes and much improved SNR.

  3. Super Sensitive Mass Detection in Nonlinear Regime

    Science.gov (United States)

    Azizi, Saber; Ahmadian, Iman; Cetinkaya, Cetin; Rezazadeh, Ghader

    2015-11-01

    Nonlinear dynamics of a clamped-clamped micro-beam exposed to a two sided electrostatic actuation is investigated to determine super sensitive regions for mass detection. The objective is to investigate the sensitivity of the frequency spectrum of various regions in the phase space to the added mass and force the system to operate in its super sensitive regions by applying an appropriate pulse to its control electrodes. The electrostatic actuation in the top electrode is a combination of a DC, AC and a pulse voltage, the excitation on the lower electrode is only a DC and a pulse voltage. The governing equation of the motion, derived using the Hamiltonian principle, is discretized to an equivalent single-degree of freedom system using the Galerkin method. Depending on the applied electrostatic voltage to the micro-beam, it is demonstrated that the number and types of equilibrium points of the system can be modified. In this study, the level of the DC electrostatic voltage is chosen such a way that the system has three equilibrium points including two centers and a saddle node where the homoclinic orbit originates. According to the reported results, the mass sensing sensitivity depends on the operating orbit; some orbits exhibit considerably higher mass detection sensitivity to the added mass compared to that of a typical quartz crystal micro balance instrument.

  4. SuperAGILE data processing services

    CERN Document Server

    Lazzarotto, F; Del Monte, E; Donnarumma, I; Evangelista, Y; Feroci, M; Lapshov, I; Pacciani, L; Soffitta, P

    2009-01-01

    The SuperAGILE (SA) instrument is a X-ray detector for As- trophysics measurements, part of the Italian AGILE satellite for X-Ray and Gamma-Ray Astronomy launched at 23/04/2007 from India. SuperAGILE is now studying the sky in the 18 - 60 KeV energy band. It is detecting sources with advanced imaging and timing detection and good spectral detection capabilities. Several astrophysical sources has been detected and localized, including Crab, Vela and GX 301-2. The instrument has the skill to resolve correctly sources in a field of view of [-40, +40] degrees interval, with the angular resolution of 6 arcmin, and a spectral analysis with the resolution of 8 keV. Transient events are regularly detected by SA with the aid of its temporal resolution (2 microsec- onds) and using signal coincidence on different portions of the instrument, with confirmation from other observatories. The SA data processing scientic software performing at the AGILE Ground Segment is divided in modules, grouped in a processing pipeline na...

  5. Convolutional Neural Network Based dem Super Resolution

    Science.gov (United States)

    Chen, Zixuan; Wang, Xuewen; Xu, Zekai; Hou, Wenguang

    2016-06-01

    DEM super resolution is proposed in our previous publication to improve the resolution for a DEM on basis of some learning examples. Meanwhile, the nonlocal algorithm is introduced to deal with it and lots of experiments show that the strategy is feasible. In our publication, the learning examples are defined as the partial original DEM and their related high measurements due to this way can avoid the incompatibility between the data to be processed and the learning examples. To further extent the applications of this new strategy, the learning examples should be diverse and easy to obtain. Yet, it may cause the problem of incompatibility and unrobustness. To overcome it, we intend to investigate a convolutional neural network based method. The input of the convolutional neural network is a low resolution DEM and the output is expected to be its high resolution one. A three layers model will be adopted. The first layer is used to detect some features from the input, the second integrates the detected features to some compressed ones and the final step transforms the compressed features as a new DEM. According to this designed structure, some learning DEMs will be taken to train it. Specifically, the designed network will be optimized by minimizing the error of the output and its expected high resolution DEM. In practical applications, a testing DEM will be input to the convolutional neural network and a super resolution will be obtained. Many experiments show that the CNN based method can obtain better reconstructions than many classic interpolation methods.

  6. Polynomial super-gl(n) algebras

    CERN Document Server

    Jarvis, P D

    2003-01-01

    We introduce a class of finite dimensional nonlinear superalgebras $L = L_{\\bar{0}} + L_{\\bar{1}}$ providing gradings of $L_{\\bar{0}} = gl(n) \\simeq sl(n) + gl(1)$. Odd generators close by anticommutation on polynomials (of degree $>1$) in the $gl(n)$ generators. Specifically, we investigate `type I' super-$gl(n)$ algebras, having odd generators transforming in a single irreducible representation of $gl(n)$ together with its contragredient. Admissible structure constants are discussed in terms of available $gl(n)$ couplings, and various special cases and candidate superalgebras are identified and exemplified via concrete oscillator constructions. For the case of the $n$-dimensional defining representation, with odd generators $Q_{a}, \\bar{Q}{}^{b}$, and even generators ${E^{a}}_{b}$, $a,b = 1,...,n$, a three parameter family of quadratic super-$gl(n)$ algebras (deformations of $sl(n/1)$) is defined. In general, additional covariant Serre-type conditions are imposed, in order that the Jacobi identities be fulf...

  7. Hot Jupiters and Super-Earths

    CERN Document Server

    Mustill, Alexander James; Johansen, Anders

    2016-01-01

    We explore the role of dynamics in shaping planetary system multiplicities, focussing on two particular problems. (1) We propose that the lack of close-in super-Earths in hot Jupiter systems is a signature of the migration history of the hot Jupiters and helps to discriminate between different mechanisms of migration. We present N-body simulations of dynamical migration scenarios where proto-hot Jupiters are excited to high eccentricities prior to tidal circularisation and orbital decay. We show that in this scenario, the eccentric giant planet typically destroys planets in the inner system, in agreement with the observed lack of close super-Earth companions to hot Jupiters. (2) We explore the role of the dynamics of outer systems in affecting the multiplicities of close-in systems such as those discovered by Kepler. We consider specifically the effects of planet--planet scattering and Kozai perturbations on an exterior giant planet on the architecture of the inner system, and evaluate the ability of such sce...

  8. Aptamer Stainings for Super-resolution Microscopy.

    Science.gov (United States)

    de Castro, Maria Angela Gomes; Rammner, Burkhard; Opazo, Felipe

    2016-01-01

    Fluorescence microscopy is an invaluable tool to visualize molecules in their biological context with ease and flexibility. However, studies using conventional light microscopy have been limited to the resolution that light diffraction allows (i.e., ~200 nm). This limitation has been recently circumvented by several types of advanced fluorescence microscopy techniques, which have achieved resolutions of up to ~10 nm. The resulting enhanced imaging precision has helped to find important cellular details that were not visible using diffraction-limited instruments. However, it has also revealed that conventional stainings using large affinity tags, such as antibodies, are not accurate enough for these imaging techniques. Since aptamers are substantially smaller than antibodies, they could provide a real advantage in super-resolution imaging. Here we compare the live staining of transferrin receptors (TfnR) obtained with different fluorescently labeled affinity probes: aptamers, specific monoclonal antibodies, or the natural receptor ligand transferrin. We observed negligible differences between these staining strategies when imaging is performed with conventional light microscopy (i.e., laser scanning confocal microscopy). However, a clear superiority of the aptamer tag over antibodies became apparent in super-resolved images obtained with stimulated emission depletion (STED) microscopy.

  9. Sala polideportiva de Super-Lioran Francia

    Directory of Open Access Journals (Sweden)

    Mazzucconi, Vittorio

    1980-12-01

    Full Text Available The polysports hall of the Super-Lioran winter resort, located in a crater filled with aliuvionary deposits, consists of two clearly differentiated parts: a lower one, of concrete, where there is the skating rink and various services, and an upper one consisting of hyperbolic paraboloid elements. This roof is of adhered laminate wood. The laminate roof structure rests on the ground, and almost merges with it, to later emerge from the snow giving the assembly almost an abstract nature which helps to increase the beauty of the area.

    La sala polideportiva de la estación invernal de Super-Lioran, situada en un cráter relleno de depósitos aluvionares, consta de dos partes claramente diferenciadas: una inferior, de hormigón, donde se encuentran la pista de patinaje y los distintos servicios, y una superior formada por elementos de paraboloide hiperbólico. Esta cubierta es de madera laminada encolada. La estructura laminar de la cubierta se apoya en el suelo casi confundiéndose con él, y luego emerge desde la nieve proporcionando al conjunto un carácter casi abstracto que contribuye a aumentar la belleza de la zona.

  10. Nanostructured coatings for super hydrophobic textiles

    Indian Academy of Sciences (India)

    M Joshi; A Bhattacharyya; N Agarwal; S Parmar

    2012-11-01

    The promising aspects of nanocomposite coatings to mimic the nano roughened self cleaning surface of lotus leaf is explored in this paper. A detailed study on nanosilica and clay based nanocomposite coatings using dip coating and layer by layer self assembly (L–b–L) is being described where lotus leaf effect has been mimicked on the cotton fabric surface using these particles as they develop nanosized surface roughness which helps to produce a super-hydrophobic surface. Nanosilica performs better in creating nano roughness on cotton fabric wherein the contact angle is >150°. The water contact angle of 2 wt% fluoro emulsion (Nuva HPU) treated cotton fabric increases from 115° to 155° when the fabric is pretreated with 0.5 wt% nanosilica emulsion. The water repellency rating of fabric treated with 0.16 wt% nanosilica along with 2 wt% Nuva HPU is comparable to that of 4 wt% Nuva HPU treated cotton fabric. On the other hand, 40 bilayers of nanosilica need to be applied on cotton fabric surface through L–b–L technique to create uniform nano roughening and gives a water repellency rating of 4. The air permeability of L–b–L nanocoated cotton fabric is not adversely affected by the super-hydrophobic nanostructured coating.

  11. The SuperNEMO double beta decay experiment

    OpenAIRE

    Nasteva, Irina; Collaboration, for the SuperNEMO

    2007-01-01

    The SuperNEMO project studies the feasibility of employing a technique of tracking plus calorimetry to search for neutrinoless double beta decay in 100 kg of enriched isotopes. It aims to reach an effective neutrino mass sensitivity of 50 meV. The current status of the SuperNEMO R&D programme is described, focusing on the main areas of improvement.

  12. Super Bowli teooria soovitab aktsiaid osta / Fredy-Edwin Esse

    Index Scriptorium Estoniae

    Esse, Fredy-Edwin

    2011-01-01

    Super Bowli teooria kohaselt tõuseb Dow Jones, kui võidab algupärase NFL-i meeskond. MarketWatchi peaökonomist Irwin Keller avaldab arvamust, miks tasuks investoritel Super Bowli tulemustele tähelepanu pöörata

  13. User Equilibrium Exchange Allocation Algorithm Based on Super Network

    Directory of Open Access Journals (Sweden)

    Peiyi Dong

    2013-12-01

    Full Text Available The theory of super network is an effective method to various traffic networks with means of multiple decision-making. It provides us with a favorable pricing decision tool for it combines a practical transport network with the space pricing decision. Spatial price equilibrium problem has always been the important research direction of the Transport Economics and regional transportation planning. As to how to combine the two, this paper presents the user equilibrium exchange allocation algorithm based on super network, which successfully keep the classical spatial price equilibrium problems (SPE into a super-network analysis framework. Through super-network analysis, we can add two virtual nodes in the network, which correspond to the virtual supply node and the super-super-demand virtual node, analysis the user equivalence with the SPE equilibrium and find the concrete steps of users exchange allocation algorithm based on super-network equilibrium. Finally, we carried out experiments to verify. The experiments show that: through the user equilibrium exchange SPE allocation algorithm based on super-network, we can get the steady-state equilibrium solution, which demonstrate that the algorithm is reasonable.

  14. Super-group field cosmology in Batalin-Vilkovisky formulation

    CERN Document Server

    Upadhyay, Sudhaker

    2016-01-01

    In this paper, we study the third quantized super-group field cosmology, a model in multiverse scenario, in Batalin-Vilkovisky (BV) formulation. Further, we propose the superfield/super-antifield dependent BRST symmetry transformations. Within this formulation, we establish connection between the two different solutions of the quantum master equation within the BV formulation.

  15. Super-Group Field Cosmology in Batalin-Vilkovisky Formulation

    Science.gov (United States)

    Upadhyay, Sudhaker

    2016-09-01

    In this paper we study the third quantized super-group field cosmology, a model in multiverse scenario, in Batalin-Vilkovisky (BV) formulation. Further, we propose the superfield/super-antifield dependent BRST symmetry transformations. Within this formulation we establish connection between the two different solutions of the quantum master equation within the BV formulation.

  16. Super Bowli teooria soovitab aktsiaid osta / Fredy-Edwin Esse

    Index Scriptorium Estoniae

    Esse, Fredy-Edwin

    2011-01-01

    Super Bowli teooria kohaselt tõuseb Dow Jones, kui võidab algupärase NFL-i meeskond. MarketWatchi peaökonomist Irwin Keller avaldab arvamust, miks tasuks investoritel Super Bowli tulemustele tähelepanu pöörata

  17. Solar neutrino measurements in Super-Kamiokande-I

    CERN Document Server

    Hosaka, J; Kameda, J; Koshio, Y; Minamino, A; Mitsuda, C; Miura, M; Moriyama, S; Nakahata, M; Namba, T; Obayashi, Y; Sakurai, N; Sarrat, A; Shiozawa, M; Suzuki, Y; Takeuchi, Y; Yamada, S; Higuchi, I; Ishitsuka, M; Kajita, T; Kaneyuki, K; Mitsuka, G; Nakayama, S; Nishino, H; Okada, A; Okumura, K; Saji, C; Takenaga, Y; Clark, S; Desai, S; Kearns, E; Likhoded, S; Stone, J L; Sulak, L R; Wang, W; Goldhaber, M; Casper, D; Cravens, J P; Kropp, W R; Liu, D W; Mine, S; Smy, M B; Sobel, H W; Sterner, C W; Vagins, M R; Ganezer, K S; Hill, J; Keig, W E; Jang, J S; Kim, J Y; Lim, I T; Scholberg, K; Walter, C W; Ellsworth, R W; Tasaka, S; Guillian, G; Kibayashi, A; Learned, J G; Matsuno, S; Messier, M D; Hayato, Y; Ichikawa, A K; Ishida, T; Ishii, T; Iwashita, T; Kobayashi, T; Nakadaira, T; Nakamura, K; Nitta, K; Oyama, Y; Totsuka, Y; Suzuki, A T; Hasegawa, M; Kato, I; Maesaka, H; Nakaya, T; Nishikawa, K; Sasaki, T; Sato, H; Yamamoto, S; Yokoyama, M; Haines, T J; Dazeley, S; Kim, B K; Lee, K B; Hatakeyama, S; Svoboda, R; Blaufuss, E; Goodman, J A; Sullivan, G W; Turcan, D; Cooley, J; Habig, A; Fukuda, Y; Sato, T; Itow, Y; Jung, C K; Kato, T; Kobayashi, K; Malek, M; Martens, K; Mauger, C; McGrew, C; Sharkey, E; Yanagisawa, C; Tamura, N; Sakuda, M; Kuno, Y; Yoshida, M; Kim, S B; Yoo, J; Okazawa, H; Ishizuka, T; Choi, Y; Seo, H K; Gando, Y; Hasegawa, T; Inoue, K; Shirai, J; Suzuki, A; Nishijima, K; Ishino, H; Watanabe, Y; Koshiba, M; Kielczewska, D; Zalipska, J; Berns, H G; Gran, R; Shiraishi, K K; Stachyra, A L; Washburn, K; Wilkes, R J

    2006-01-01

    The details of Super--Kamiokande--I's solar neutrino analysis are given. Solar neutrino measurement in Super--Kamiokande is a high statistics collection of $^8$B solar neutrinos via neutrino-electron scattering. The analysis method and results of the 1496 day data sample are presented. The final oscillation results for the data are also presented.

  18. Analysing 'super-participation' in online third spaces

    NARCIS (Netherlands)

    Graham, Todd; Wright, Scott; Cantijoch, Marta; Gibson, Rachel; Ward, Stephen

    2014-01-01

    This chapter focuses on our attempts to overcome the methodological challenges of 'super-participation' in online discussion forums, focusing on the participatory patterns and discursive activity of what we call 'super-participants'. Our principal contribution in this area (Graham and Wright 2013) f

  19. Fixed Point Actions for Lattice Fermions

    CERN Document Server

    Bietenholz, W

    1994-01-01

    The fixed point actions for Wilson and staggered lattice fermions are determined by iterating renormalization group transformations. In both cases a line of fixed points is found. Some points have very local fixed point actions. They can be used to construct perfect lattice actions for asymptotically free fermionic theories like QCD or the Gross-Neveu model. The local fixed point actions for Wilson fermions break chiral symmetry, while in the staggered case the remnant $U(1)_e \\otimes U(1)_o$ symmetry is preserved. In addition, for Wilson fermions a nonlocal fixed point is found that corresponds to free chiral fermions. The vicinity of this fixed point is studied in the Gross-Neveu model using perturbation theory.

  20. Practices and Prospects of Super Hybrid Rice Breeding

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The great progress in super rice breeding both in China and other countries has been made in recent years.However, there were three main problems in super rice breeding: 1) the super rice varieties were still rare; 2) most super rice varieties exhibited narrow adaptability; and 3) current breeding theories emphasized too much on the rice growth model, but they were unpractical in guidance for rice breeding. According to the authors' experience on the rice breeding, the breeding strategies including three steps (super parent breeding, super hybrid rice breeding and super hybrid rice seed production)were proposed, and the objectives of each step and the key technologies to achieve the goals were elucidated in detail. The super parent of hybrid rice should exhibit excellent performance in all agronomic traits, with the yield or sink capacity reached the level of the hybrid rice control in regional trials. The super hybrid rice combination should meet the following criteria: good rice quality, wide adaptation, lodging resistance, resistance to main insects and diseases, and the yield exceeded above 8%over the control varieties in the national and provincial regional trials. To achieve the goal, the technical strategies, such as selecting optimal combination of the parents, increasing selection pressure, paying more attention to harmony of ideal plant type, excellent physiological traits and all the agronomic traits, should be emphasized. The yield of seed production should reach 3.75 t/ha and 5.25 t/ha for the super hybrid rice combinations derived from early-season and middle-season types of male sterile lines, respectively. The main technologies for raising seed production yield included selecting optimum seed production site, using the male sterile line with large sink capacity and good outcrossing characteristics, and improving the amount of the pollen by intensive cultivation of the male parent. According to the technologies of the three-step breeding on super

  1. Fixed telephony evolution at CERN

    CERN Document Server

    CERN. Geneva

    2015-01-01

    The heart of CERN’s telephony infrastructure consists of the Alcatel IP-PBX that links CERN’s fixed line phones, Lync softphones and CERN’s GSM subscribers to low-cost local and international telephony services. The PABX infrastructure also supports the emergency “red telephones” in the LHC tunnel and provides vital services for the Fire and Rescue Service and the CERN Control Centre. Although still reliable, the Alcatel hardware is increasingly costly to maintain and looking increasingly outmoded in a market where open source solutions are increasingly dominant. After presenting an overview of the Alcatel PABX and the services it provides, including innovative solutions such as the Closed User Group for our mobile telephony services, we present a possible architecture for a software based system designed to meet tomorrow’s communication needs and describe how the introduction of open-source call routers based on the SIP protocol and Session Border Controllers (SBC) could foster the introduction...

  2. Fixed drug eruptions with modafinil

    Directory of Open Access Journals (Sweden)

    Loknath Ghoshal

    2015-01-01

    Full Text Available Modafinil is a psychostimulant drug, which has been approved by the US Food and Drug Administration for the treatment of narcolepsy associated excessive daytime sleepiness, sleep disorder related to shift work, and obstructive sleep apnea syndrome. However, presently it is being used as a lifestyle medicine; in India, it has been misused as an "over the counter" drug. Modafinil is known to have several cutaneous side effects. Fixed drug eruption (FDE is a distinctive drug induced reaction pattern characterized by recurrence of eruption at the same site of the skin or mucous membrane with repeated systemic administration. Only two case reports exist in the literature describing modafinil induced FDE until date. Here, we report two similar cases. The increasing use of this class of drug amongst the medical personnel might be posing a threat to the proper use and encouraging subsequent abuse. There might be a considerable population using these drugs unaware of the possible adverse effects. Authorities should be more alert regarding the sale and distribution of such medicines.

  3. ON THE RADIAL GROUND STATE OF P-LAPLACIAN EQUATION INVOLVING SUPER-CRITICAL OR CRITICAL EXPONENTS

    Institute of Scientific and Technical Information of China (English)

    Xuan Benjin; Chen Zuchi

    2000-01-01

    In this paper, we consider the existence and uniqueness of the radial ground state to the following p-Laplacian equation involving super-critical or critical exponents: Δpu + uq - |Du|σ = 0, x ∈ Rn, 2 < p < n, q _> [n(p - 1) + p]/(n - p), σ > 0. Applying the shooting argument, the Schauder's fixed point theorem and some delicate estimates of auxiliary functions, we study the influence of the parameters n, p, q, σ on the existence and uniqueness of the radial ground state to the above p-Laplacian equation.

  4. Super-resolved imaging with ultimate time resolution

    CERN Document Server

    Ashida, Yuto

    2015-01-01

    Precisely and accurately locating point objects is a long-standing common thread in science. Super-resolved imaging of single molecules has revolutionized our view of quasi-static nanostructures $\\it{in-vivo}$. A wide-field approach based on localizing individual fluorophores has emerged as a versatile method to surpass the standard resolution limit. In those techniques, the super-resolution is realized by sparse photoactivation and localization together with the statistical analysis based on point spread functions. Nevertheless, the slow temporal resolution of super-resolved imaging severely restricts the utility to the study of live-cell phenomena. Clearly, a major breakthrough to observe fast, nanoscale dynamics needs to be made. Here we present a super-resolved imaging method that achieves the theoretical-limit time resolution. By invoking information theory, we can achieve the robust localization of overlapped light emitters at an order of magnitude faster speed than the conventional super-resolution mic...

  5. Complete control, direct observation and study of molecular super rotors

    CERN Document Server

    Korobenko, Aleksey; Milner, Valery

    2013-01-01

    Extremely fast rotating molecules carrying significantly more energy in their rotation than in any other degree of freedom are known as "super rotors". It has been speculated that super rotors may exhibit a number of unique and intriguing properties. Theoretical studies showed that ultrafast molecular rotation may change the character of molecular scattering from solid surfaces, alter molecular trajectories in external fields, make super rotors surprisingly stable against collisions, and lead to the formation of gas vortices. New ways of molecular cooling and selective chemical bond breaking by ultrafast spinning have been proposed. Owing to the fundamental laws of nature, bringing a large number of molecules to fast, directional and synchronous rotation is rather challenging. As a result, only indirect evidence of super rotors has been reported to date. Here we demonstrate the first controlled creation, direct observation and study of molecular super rotors. Using intense laser pulses tailored to produce an ...

  6. A Super Version of the Connes-Moscovici Hopf Algebra

    CERN Document Server

    Khalkhali, Masoud

    2010-01-01

    We define a super version of the Connes-Moscovici Hopf algebra, $\\mathcal{H}_1$. For that, we consider the supergroup $G^s=Diff^+(\\mathbb{R}^{1,1})$ of orientation preserving diffeomorphisms of the superline $\\mathbb{R}^{1,1}$ and define two (super) subgroups $G^s_1$ and $G^s_2$ of $G^s$ where $G^s_1$ is the supergroup of affine transformations. The super Hopf algebra $\\mathcal{H} ^s_1$ is defined as a certain bicrossproduct super Hopf algebra of the super Hopf algebras attached to $G^s_1$ and $G^s_2$. We also give an explicit description of $\\mathcal{H} ^s_1$ in terms of generators and relations.

  7. Optimal Measures for Characterizing Water-rich Super-Earths

    CERN Document Server

    Madhusudhan, Nikku

    2014-01-01

    The detection and atmospheric characterization of super-Earths is one of the major frontiers of exoplanetary science. Currently, extensive efforts are underway to detect molecules, particularly H2O, in super-Earth atmospheres. In the present work, we develop a systematic set of strategies to identify and observe potentially H2O-rich super-Earths that provide the best prospects for characterizing their atmospheres using existing instruments. Firstly, we provide analytic prescriptions and discuss factors that need to be taken into account while planning and interpreting observations of super-Earth radii and spectra. We discuss how observations in different spectral bandpasses constrain different atmospheric properties of a super-Earth, including radius and temperature of the planetary surface as well as the mean molecular mass, the chemical composition and thermal profile of the atmosphere. In particular, we caution that radii measured in certain bandpasses can induce biases in the interpretation of the interio...

  8. Fixed Export Costs and Export Behavior

    OpenAIRE

    Castro, Luis; Li, Ben; Keith E. Maskus; Xie, Yiqing

    2014-01-01

    This paper provides a direct test of how fixed export costs and productivity jointly determine firm-level export behavior. Using Chilean data, we construct indices of fixed export costs for each industry-region-year triplet and match them to domestic firms. Our empirical results show that firms facing higher fixed export costs are less likely to export, while those with higher productivity export more. These outcomes are the foundation of the widely-used sorting mechanism in the trade models ...

  9. Fixed-point-like theorems on subspaces

    Directory of Open Access Journals (Sweden)

    Bernard Cornet

    2004-08-01

    Full Text Available We prove a fixed-point-like theorem for multivalued mappings defined on the finite Cartesian product of Grassmannian manifolds and convex sets. Our result generalizes two different kinds of theorems: the fixed-point-like theorem by Hirsch et al. (1990 or Husseini et al. (1990 and the fixed-point theorem by Gale and Mas-Colell (1975 (which generalizes Kakutani's theorem (1941.

  10. A Novel Exact Fixed-node Quantum Monte Carlo Algorithm

    Institute of Scientific and Technical Information of China (English)

    Hong Xin HUANG

    2004-01-01

    In this paper we proposed a novel exact fixed-node quantum Monte Carlo (EFNQMC) algorithm, which is a self-optimizing and self-improving procedure. In contrast to the previous EFNQMC method, the trial function is optimized synchronistically in the diffusion procedure, but not before the beginning of EFNQMC computation. In order to optimize the trial function, the improved steepest descent technique is used, in which the step size is automatically adjustable. The procedure is quasi-Newton and converges super linearly. We also use a novel trial function, which has correct electron-electron and electron-nucleus cusp conditions. The novel EFNQMC algorithm and the novel trial function are employed to calculate the energies of 11A1 state of CH2, 1Ag state of C8 and the ground-states of H2, LiH, Li2, H2O, respectively. The test results show that both the novel algorithm and the trial function proposed in the present paper are very excellent.

  11. Fixed point theorems in spaces and -trees

    Directory of Open Access Journals (Sweden)

    Kirk WA

    2004-01-01

    Full Text Available We show that if is a bounded open set in a complete space , and if is nonexpansive, then always has a fixed point if there exists such that for all . It is also shown that if is a geodesically bounded closed convex subset of a complete -tree with , and if is a continuous mapping for which for some and all , then has a fixed point. It is also noted that a geodesically bounded complete -tree has the fixed point property for continuous mappings. These latter results are used to obtain variants of the classical fixed edge theorem in graph theory.

  12. Fixed Simplex Property for Retractable Complexes

    Directory of Open Access Journals (Sweden)

    Zapart Anna

    2010-01-01

    Full Text Available Abstract Retractable complexes are defined in this paper. It is proved that they have the fixed simplex property for simplicial maps. This implies the theorem of Wallace and the theorem of Rival and Nowakowski for finite trees: every simplicial map transforming vertices of a tree into itself has a fixed vertex or a fixed edge. This also implies the Hell and Nešetřil theorem: any endomorphism of a dismantlable graph fixes some clique. Properties of recursively contractible complexes are examined.

  13. Classification system adopted for fixed cutter bits

    Energy Technology Data Exchange (ETDEWEB)

    Winters, W.J.; Doiron, H.H.

    1988-01-01

    The drilling industry has begun adopting the 1987 International Association of Drilling Contractors' (IADC) method for classifying fixed cutter drill bits. By studying the classification codes on bit records and properly applying the new IADC fixed cutter dull grading system to recently run bits, the end-user should be able to improve the selection and usage of fixed cutter bits. Several users are developing databases for fixed cutter bits in an effort to relate field performance to some of the more prominent bit design characteristics.

  14. Bayesian Deconvolution for Angular Super-Resolution in Forward-Looking Scanning Radar

    Directory of Open Access Journals (Sweden)

    Yuebo Zha

    2015-03-01

    Full Text Available Scanning radar is of notable importance for ground surveillance, terrain mapping and disaster rescue. However, the angular resolution of a scanning radar image is poor compared to the achievable range resolution. This paper presents a deconvolution algorithm for angular super-resolution in scanning radar based on Bayesian theory, which states that the angular super-resolution can be realized by solving the corresponding deconvolution problem with the maximum a posteriori (MAP criterion. The algorithm considers that the noise is composed of two mutually independent parts, i.e., a Gaussian signal-independent component and a Poisson signal-dependent component. In addition, the Laplace distribution is used to represent the prior information about the targets under the assumption that the radar image of interest can be represented by the dominant scatters in the scene. Experimental results demonstrate that the proposed deconvolution algorithm has higher precision for angular super-resolution compared with the conventional algorithms, such as the Tikhonov regularization algorithm, the Wiener filter and the Richardson–Lucy algorithm.

  15. RF plasma based selective modification of hydrophilic regions on super hydrophobic surface

    Science.gov (United States)

    Lee, Jaehyun; Hwang, Sangyeon; Cho, Dae-Hyun; Hong, Jungwoo; Shin, Jennifer H.; Byun, Doyoung

    2017-02-01

    Selective modification and regional alterations of the surface property have gained a great deal of attention to many engineers. In this paper, we present a simple, a cost-effective, and amendable reforming method for disparate patterns of hydrophilic regions on super-hydrophobic surfaces. Uniform super-hydrophobic layer (Contact angle; CA > 150°, root mean square (RMS) roughness ∼0.28 nm) can be formed using the atmospheric radio frequency (RF) plasma on top of the selective hydrophilic (CA ∼ 70°, RMS roughness ∼0.34 nm) patterns imprinted by electrohydrodynamic (EHD) jet printing technology with polar alcohols (butyl carbitol or ethanol). The wettability of the modified surface was investigated qualitatively utilizing scanning electron microscopy (SEM), atomic force microscopy (AFM), and wavelength scanning interferometer (WSI). Secondary ion mass spectroscopy (SIMS) analysis showed that the alcohol addiction reaction changed the types of radicals on the super-hydrophobic surface. The wettability was found to depend sensitively on chemical radicals on the surface, not on surface morphology (particle size and surface roughness). Furthermore, three different kinds of representative hydrophilic samples (polystyrene nano-particle aqueous solution, Salmonella bacteria medium, and poly(3,4-ethylenediocythiophene) ink) were tested for uniform deposition onto the desired hydrophilic regions. This simple strategy would have broad applications in various research fields that require selective deposition of target materials.

  16. Radiation protection design for the Super-FRS and SIS100 at the international FAIR facility

    Science.gov (United States)

    Kozlova, Ekaterina; Sokolov, Alexey; Radon, Torsten; Lang, Rupert; Conrad, Inna; Fehrenbacher, Georg; Weick, Helmut; Winkler, Martin

    2017-09-01

    The new accelerator SIS100 and the Super-FRS will be built at the international Facility for Antiprotons and Ion Research FAIR. The synchrotron SIS100 is a core part of the FAIR facility which serves for acceleration of ions like Uranium up to 2.7 GeV/u with intensities of 3x1011 particles per second or protons up to 30 GeV with intensities of 5x1012 particles per second. The Super-FRS is a superconducting fragment separator, it will be able to separate all kinds of nuclear projectile fragments of primary heavy ion beams including Uranium with energies up to 1.5 GeV/u and intensities up to 3x1011 particles per second. During operation activation of several components, especially the production target and the beam catchers will take place. For handling of highly activated components it is foreseen to have a hot cell with connected storage place. All calculations for the optimisation of the shielding design of the SIS100, the Super-FRS and the hot cell were performed using the Monte Carlo code FLUKA, results are presented.

  17. Highly selective creation of hydrophilic micro-craters on super hydrophobic surface using electrohydrodynamic jet printing

    Science.gov (United States)

    Lee, Jaehyun; Hwang, Sangyeon; Prasetyo, Fariza Dian; Nguyen, Vu Dat; Hong, Jungwoo; Shin, Jennifer H.; Byun, Doyoung

    2014-11-01

    Selective surface modification is considered as an alternative to conventional printing techniques in high resolution patterning. Here, we present fabrication of hydrophilic patterns on the super hydrophobic surface, which makes structure on the hydrophilic region. The super hydrophobic surface is able to be chemically changed to hydrophilic with alcohols. As a consecutive process, electrohydrodynamic (EHD) jet printing was utilized to fabricate local hydrophilic craters with 30-200 μm sizes. 3 kinds of target liquids were deposited well on hydrophilic region; PEDOT (poly 3,4 ethylenediocythiophene), polystyrene nano-particles, and salmonella bacteria medium. Additionally, qualitative analysis were presented for modification mechanism and surface properties on super hydrophobic/hydrophilic by analysis of surface energy with contact angle, SEM (scanning electron microscopy) image, and SIMS (secondary ion mass spectroscopy) analysis. This new simple modification method provides possibility to be utilizing in bio-patterning engineering such as cell culturing microchip and lab on a chip. This research was supported by the Basi Science Research Program through the National Research Foundation of Korea (NRF) (Grand Number: 2014-023284).

  18. A Spitzer Search for Transits of Radial Velocity Detected Super-Earths

    CERN Document Server

    Kammer, J A; Howard, A W; Laughlin, G P; Deming, D; Todorov, K O; Desert, J -M; Agol, E; Burrows, A; Fortney, J J; Showman, A P; Lewis, N K

    2013-01-01

    Unlike hot Jupiters or other gas giants, super-Earths are expected to have a wide variety of compositions, ranging from terrestrial bodies like our own to more gaseous planets like Neptune. Observations of transiting systems, which allow us to directly measure planet masses and radii and constrain atmospheric properties, are key to understanding the compositional diversity of the planets in this mass range. Although Kepler has discovered hundreds of transiting super-Earth candidates over the past four years, the majority of these planets orbit stars that are too far away and too faint to allow for detailed atmospheric characterization and reliable mass estimates. Ground-based transit surveys focus on much brighter stars, but most lack the sensitivity to detect planets in this size range. One way to get around the difficulty of finding these smaller planets in transit is to start by choosing targets that are already known to contain super-Earth sized bodies detected using the radial velocity technique. Here we...

  19. Giant Impact: An Efficient Mechanism for Devolatilization of Super-Earths

    CERN Document Server

    Liu, Shang-Fei; Lin, D N C; Asphaug, Erik

    2015-01-01

    Mini-Neptunes and volatile-poor super-Earths coexist on adjacent orbits in proximity to host stars such as Kepler-36 and Kepler-11. Several post-formation processes have been proposed for explaining the origin of the compositional diversity: the mass loss via stellar XUV irradiation, degassing of accreted material, and in-situ accumulation of the disk gas. Close-in planets are also likely to experience giant impacts during the advanced stage of planet formation. This study examines the possibility of transforming volatile-rich super-Earths / mini-Neptunes into volatile-depleted super-Earths through giant impacts. We present the results of three-dimensional giant impact simulations in the accretionary and disruptive regimes. Target planets are modeled with a three-layered structure composed of an iron core, silicate mantle and hydrogen/helium envelope. In the disruptive case, the giant impact can remove most of the H/He atmosphere immediately and homogenize the refractory material in the planetary interior. In...

  20. Bayesian deconvolution for angular super-resolution in forward-looking scanning radar.

    Science.gov (United States)

    Zha, Yuebo; Huang, Yulin; Sun, Zhichao; Wang, Yue; Yang, Jianyu

    2015-03-23

    Scanning radar is of notable importance for ground surveillance, terrain mapping and disaster rescue. However, the angular resolution of a scanning radar image is poor compared to the achievable range resolution. This paper presents a deconvolution algorithm for angular super-resolution in scanning radar based on Bayesian theory, which states that the angular super-resolution can be realized by solving the corresponding deconvolution problem with the maximum a posteriori (MAP) criterion. The algorithm considers that the noise is composed of two mutually independent parts, i.e., a Gaussian signal-independent component and a Poisson signal-dependent component. In addition, the Laplace distribution is used to represent the prior information about the targets under the assumption that the radar image of interest can be represented by the dominant scatters in the scene. Experimental results demonstrate that the proposed deconvolution algorithm has higher precision for angular super-resolution compared with the conventional algorithms, such as the Tikhonov regularization algorithm, the Wiener filter and the Richardson-Lucy algorithm.

  1. Live-cell super-resolution imaging of intrinsically fast moving flagellates

    Science.gov (United States)

    Glogger, M.; Stichler, S.; Subota, I.; Bertlein, S.; Spindler, M.-C.; Teßmar, J.; Groll, J.; Engstler, M.; Fenz, S. F.

    2017-02-01

    Recent developments in super-resolution microscopy make it possible to resolve structures in biological cells at a spatial resolution of a few nm and observe dynamical processes with a temporal resolution of ms to μs. However, the optimal structural resolution requires repeated illumination cycles and is thus limited to chemically fixed cells. For live cell applications substantial improvement over classical Abbe-limited imaging can already be obtained in adherent or slow moving cells. Nonetheless, a large group of cells are fast moving and thus could not yet be addressed with live cell super-resolution microscopy. These include flagellate pathogens like African trypanosomes, the causative agents of sleeping sickness in humans and nagana in livestock. Here, we present an embedding method based on a in situ forming cytocompatible UV-crosslinked hydrogel. The fast cross-linking hydrogel immobilizes trypanosomes efficiently to allow microscopy on the nanoscale. We characterized both the trypanosomes and the hydrogel with respect to their autofluorescence properties and found them suitable for single-molecule fluorescence microscopy (SMFM). As a proof of principle, SMFM was applied to super-resolve a structure inside the living trypanosome. We present an image of a flagellar axoneme component recorded by using the intrinsic blinking behavior of eYFP. , which features invited work from the best early-career researchers working within the scope of J Phys D. This project is part of the Journal of Physics series’ 50th anniversary celebrations in 2017. Susanne Fenz was selected by the Editorial Board of J Phys D as an Emerging Talent/Leader.

  2. Factors influencing bonding fixed restorations

    Directory of Open Access Journals (Sweden)

    Medić Vesna

    2008-01-01

    Full Text Available INTRODUCTION Crown displacement often occurs because the features of tooth preparations do not counteract the forces directed against restorations. OBJECTIVE The purpose of this study was to evaluate the effect of preparation designs on retention and resistance of fixed restorations. METHOD The study was performed on 64 differently sized stainless steel dies. Also, caps which were used for evaluated retention were made of stainless steel for each die. After cementing the caps on experimental dies, measuring of necessary tensile forces to separate cemented caps from dies was done. Caps, which were made of a silver-palladium alloy with a slope of 60° to the longitudinal axis formed on the occlusal surface, were used for evaluating resistance. A sudden drop in load pressure recorded by the test machine indicated failure for that cap. RESULTS A significant difference was found between the tensile force required to remove the caps from the dies with different length (p<0.05 and different taper (p<0.01. The greatest retentive strengths (2579.2 N and 2989.8 N were noticed in experimental dies with the greatest length and smallest taper. No statistically significant (p>0.05 differences were found between tensile loads for caps cemented on dies with different diameter. Although there was an apparent slight increase in resistance values for caps on dies with smaller tapers, the increase in resistance for those preparation designs was not statistically significant. There was a significant difference among the resistance values for caps on dies with different length (p<0.01 and diameter (p<0.05. CONCLUSION In the light of the results obtained, it could be reasonably concluded that retention and resistance of the restoration is in inverse proportion to convergence angle of the prepared teeth. But, at a constant convergence angle, retention and resistance increase with rising length and diameter.

  3. Ciprofloxacin induced fixed drug eruption

    Directory of Open Access Journals (Sweden)

    M. Ravishankar

    2014-12-01

    Full Text Available Fixed drug eruption (FDE is a clinical entity occurring in the same site or sites each time the drug is administered. Acute lesions appear as sharply marginated erythematous plaques, which are usually found on lips, genitalia, abdomen, and legs. The eruptions usually occur within hours of administration of the offending agent and resolves spontaneously without scarring after few weeks of onset. Most common drugs causing FDE are sulfonamides, tetracyclines, salicylates, barbiturates, doxycycline, fluconazole, clarithromycin, etc. Ciprofloxacin, a widely used fluoroquinolone antimicrobial, induces cutaneous adverse drug reactions (ADRs in about 1-2% of treated patients. Urticaria, angioedema, maculopapular exanthems, and photosensitivity are the most frequently documented cutaneous adverse reactions. In this case report, the patient soon after taking ciprofloxacin tablets, developed itching in the lips, palms and in scrotal region. On continuing the treatment, the next day he developed fluid filled lesions over palm, knuckle, and hyperpigmentation. He gives a history of severe itching and rashes in scrotal region. He gives a history of similar complaints in the previous month after taking ciprofloxacin medication. There was no history of intake of any other medication. On examination, bullous lesions and pustules in finger webs, hyperpigmentation on knuckles, and scrotal erosions were seen. In the present case report, the patient presented with FDE immediately after oral administration of ciprofloxacin and got completely cured after stopping the drug and taking adequate treatment. According to the Naranjo's ADR probability scale (score=8, this ADR is categorized as a and ldquo;probable and rdquo; reaction to the drug. [Int J Basic Clin Pharmacol 2014; 3(6.000: 1096-1097

  4. A Super-resolution Reconstruction Algorithm for Surveillance Video

    Directory of Open Access Journals (Sweden)

    Jian Shao

    2017-01-01

    Full Text Available Recent technological developments have resulted in surveillance video becoming a primary method of preserving public security. Many city crimes are observed in surveillance video. The most abundant evidence collected by the police is also acquired through surveillance video sources. Surveillance video footage offers very strong support for solving criminal cases, therefore, creating an effective policy, and applying useful methods to the retrieval of additional evidence is becoming increasingly important. However, surveillance video has had its failings, namely, video footage being captured in low resolution (LR and bad visual quality. In this paper, we discuss the characteristics of surveillance video and describe the manual feature registration – maximum a posteriori – projection onto convex sets to develop a super-resolution reconstruction method, which improves the quality of surveillance video. From this method, we can make optimal use of information contained in the LR video image, but we can also control the image edge clearly as well as the convergence of the algorithm. Finally, we make a suggestion on how to adjust the algorithm adaptability by analyzing the prior information of target image.

  5. The elastic buckling of super-graphene and super-square carbon nanotube networks

    Energy Technology Data Exchange (ETDEWEB)

    Li Ying; Qiu Xinming [AML, Department of Engineering Mechanics, School of Aerospace, Tsinghua University, 100084 Beijing (China); Yin Yajun, E-mail: yinyj@tsinghua.edu.c [AML, Department of Engineering Mechanics, School of Aerospace, Tsinghua University, 100084 Beijing (China)] [Division of Mechanics, Nanjing University of Technology, 210009 Nanjing (China); Yang Fan [AML, Department of Engineering Mechanics, School of Aerospace, Tsinghua University, 100084 Beijing (China); Fan Qinshan [Division of Mechanics, Nanjing University of Technology, 210009 Nanjing (China)

    2010-04-05

    The super-graphene (SG) and super-square (SS) carbon nanotube network are built by the straight single-walled carbon nanotubes and corresponding junctions. The elastic buckling behaviors of these carbon nanotube networks under different boundary conditions are explored through the molecular structural mechanics method. The following results are obtained: (a) The critical buckling forces of the SG and SS networks decrease as the side lengths or aspect ratios of the networks increase. The continuum plate theory could give good predictions to the buckling of the SS network but not the SG network with non-uniform buckling modes. (b) The carbon nanotube networks are more stable structures than the graphene structures with less carbon atoms.

  6. Experimental demonstration of light capsule embracing super-sized darkness inside via super-anti-resolution

    CERN Document Server

    Wan, Chao; Han, Tiancheng; Leong, Eunice; Ding, Weiqiang; Yeo, Tat-Soon; Yu, Xia; Teng, Jinghua; Lei, Dang Yuan; Maier, Stefan A; Lukyanchuk, Boris; Zhang, Shuang; Qiu, Cheng-Wei

    2013-01-01

    Ijon Tichy lamp allows to focus the macroscopic perfect 3D darkness surrounded by all light in the shined room. The object staying in the darkness is similar to staying in an empty light capsule because light just bypasses it. Its functionality of bending light macroscopically is fascinating, similar in some sense to the transformation-based cloaking effect. Here, we theoretically and experimentally demonstrate a binary-optical system exhibiting super-anti-resolution (SAR), in which electromagnetic energy flux avoids and bends smoothly around a nearly perfect darkness region. SAR remains an unexplored topic hitherto, in contrast to the super-resolution for realizing high spatial resolution. This novel scheme replies on smearing out the PSF perfectly and thus poses less stringent limitations upon the object size and position since the created nearly-perfect dark (zero-field) area reach 10 orders of magnitude larger than square of wavelength in size. Conceptually, it represents a novel implementation of Ijon Ti...

  7. From heavy nuclei to super-heavy nuclei; Des noyaux lourds aux super-lourds

    Energy Technology Data Exchange (ETDEWEB)

    Theisen, Ch

    2003-01-01

    The existence of super-heavy nuclei has been predicted nearly fifty years ago. Due to the strong coulomb repulsion, the stabilisation of these nuclei is possible only through shell effects. The reasons for this fragile stability, as well as the theoretical predictions concerning the position of the island of stability are presented in the first part of this lecture. In the second part, experiments and experimental techniques which have been used to synthesize or search for super-heavy elements are described. Spectroscopic studies performed in very heavy elements are presented in the following section. We close this lecture with techniques that are currently being developed in order to reach the superheavy island and to study the structure of very-heavy nuclei. (author)

  8. Efficient and Effective Total Variation Image Super-Resolution: A Preconditioned Operator Splitting Approach

    Directory of Open Access Journals (Sweden)

    Li-Li Huang

    2011-01-01

    Full Text Available Super-resolution is a fusion process for reconstructing a high-resolution image from a set of low-resolution images. This paper proposes a novel approach to image super-resolution based on total variation (TV regularization. We applied the Douglas-Rachford splitting technique to the constrained TV-based variational SR model which is separated into three subproblems that are easy to solve. Then, we derive an efficient and effective iterative scheme, which includes a fast iterative shrinkage/thresholding algorithm for denoising problem, a very simple noniterative algorithm for fusion part, and linear equation systems for deblurring process. Moreover, to speed up convergence, we provide an accelerated scheme based on precondition design of initial guess and forward-backward splitting technique which yields linear systems of equations with a nice structure. The proposed algorithm shares a remarkable simplicity together with a proven global rate of convergence which is significantly better than currently known lagged diffusivity fixed point iteration algorithm and fast decoupling algorithm by exploiting the alternating minimizing approach. Experimental results are presented to illustrate the effectiveness of the proposed algorithm.

  9. A Spitzer search for transits of radial velocity detected super-Earths

    Energy Technology Data Exchange (ETDEWEB)

    Kammer, J. A.; Knutson, H. A.; Desert, J.-M. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Howard, A. W. [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Laughlin, G. P.; Fortney, J. J. [Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Deming, D. [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States); Todorov, K. O. [Institute for Astronomy, ETH Zürich, CH-8093 Zürich (Switzerland); Agol, E. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Burrows, A. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Showman, A. P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Lewis, N. K., E-mail: jkammer@caltech.edu [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)

    2014-02-01

    Unlike hot Jupiters or other gas giants, super-Earths are expected to have a wide variety of compositions, ranging from terrestrial bodies like our own to more gaseous planets like Neptune. Observations of transiting systems, which allow us to directly measure planet masses and radii and constrain atmospheric properties, are key to understanding the compositional diversity of the planets in this mass range. Although Kepler has discovered hundreds of transiting super-Earth candidates over the past 4 yr, the majority of these planets orbit stars that are too far away and too faint to allow for detailed atmospheric characterization and reliable mass estimates. Ground-based transit surveys focus on much brighter stars, but most lack the sensitivity to detect planets in this size range. One way to get around the difficulty of finding these smaller planets in transit is to start by choosing targets that are already known to host super-Earth sized bodies detected using the radial velocity (RV) technique. Here we present results from a Spitzer program to observe six of the most favorable RV-detected super-Earth systems, including HD 1461, HD 7924, HD 156668, HIP 57274, and GJ 876. We find no evidence for transits in any of their 4.5 μm flux light curves, and place limits on the allowed transit depths and corresponding planet radii that rule out even the most dense and iron-rich compositions for these objects. We also observed HD 97658, but the observation window was based on a possible ground-based transit detection that was later ruled out; thus the window did not include the predicted time for the transit detection recently made by the Microvariability and Oscillations of Stars space telescope.

  10. A Total Variation Regularization Based Super-Resolution Reconstruction Algorithm for Digital Video

    Directory of Open Access Journals (Sweden)

    Zhang Liangpei

    2007-01-01

    Full Text Available Super-resolution (SR reconstruction technique is capable of producing a high-resolution image from a sequence of low-resolution images. In this paper, we study an efficient SR algorithm for digital video. To effectively deal with the intractable problems in SR video reconstruction, such as inevitable motion estimation errors, noise, blurring, missing regions, and compression artifacts, the total variation (TV regularization is employed in the reconstruction model. We use the fixed-point iteration method and preconditioning techniques to efficiently solve the associated nonlinear Euler-Lagrange equations of the corresponding variational problem in SR. The proposed algorithm has been tested in several cases of motion and degradation. It is also compared with the Laplacian regularization-based SR algorithm and other TV-based SR algorithms. Experimental results are presented to illustrate the effectiveness of the proposed algorithm.

  11. STED super-resolution microscopy in Drosophila tissue and in mammalian cells

    Science.gov (United States)

    Lau, Lana; Lee, Yin Loon; Matis, Maja; Axelrod, Jeff; Stearns, Tim; Moerner, W. E.

    2011-03-01

    Far-field super-resolution microscopy is a rapidly emerging method that is opening up opportunities for biological imaging beyond the optical diffraction limit. We have implemented a Stimulated Emission Depletion (STED) microscope to image single dye, cell, and tissue samples with 50-80 nm resolution. First, we compare the STED performance imaging single molecules of several common dyes and report a novel STED dye. Then we apply STED to image planar cell polarity protein complexes in intact fixed Drosophila tissue for the first time. Finally, we present a preliminary study of the centrosomal protein Cep164 in mammalian cells. Our images suggest that Cep164 is arranged in a nine-fold symmetric pattern around the centriole, consistent with findings suggested by cryoelectron tomography. Our work demonstrates that STED microscopy can be used for superresolution imaging in intact tissue and provides ultrastructural information in biological samples as an alternative to immuno-electron microscopy.

  12. Super-accelerating bouncing cosmology in asymptotically free non-local gravity

    Energy Technology Data Exchange (ETDEWEB)

    Calcagni, Gianluca [CSIC, Instituto de Estructura de la Materia, Madrid (Spain); Modesto, Leonardo [Fudan University, Department of Physics and Center for Field Theory and Particle Physics, Shanghai (China); Nicolini, Piero [Johann Wolfgang Goethe-Universitaet, Frankfurt Institute for Advanced Studies (FIAS) und Institut fuer Theoretische Physik, Frankfurt am Main (Germany)

    2014-08-15

    Recently, evidence has been collected that a class of gravitational theories with certain non-local operators is renormalizable. We consider one such model which, at the linear perturbative level, reproduces the effective non-local action for the light modes of bosonic closed string-field theory. Using the property of asymptotic freedom in the ultraviolet and fixing the classical behavior of the scale factor at late times, an algorithm is proposed to find general homogeneous cosmological solutions valid both at early and late times. Imposing a power-law classical limit, these solutions (including anisotropic ones) display a bounce, instead of a big-bang singularity, and super-accelerate near the bounce even in the absence of an inflaton or phantom field. (orig.)

  13. What is so super about super-emitters? Characterizing methane high emitters from natural gas infrastructure

    Science.gov (United States)

    Zavala Araiza, D.; Lyon, D. R.; Alvarez, R.; Harriss, R. C.; Palacios, V.; Hamburg, S.

    2015-12-01

    Methane emissions across the natural gas supply chain are dominated at any one time by a few high-emitters (super-emitters or fat-tail of the distribution), often underrepresented in published datasets used to construct emission inventories. Characterization of high-emitters is essential for improving emission estimates based on atmospheric data (top-down) and emission inventories (bottom-up). The population of high-emitters (e.g. 10-20% of sites that account for 80-90% of the emissions) is temporally and spatially dynamic. As a consequence, it is challenging to design sampling methods and construct estimates that accurately represent their frequency and magnitude of emissions. We present new methods to derive facility-specific emission distribution functions that explicitly integrate the influence of the relatively rare super-emitters. These methods were applied in the Barnett Shale region to construct a custom emission inventory that is then compared to top-down emission estimates for the region. We offer a methodological framework relevant to the design of future sampling campaigns, in which these high-emitters are seamlessly incorporated to representative emissions distributions. This framework can be applied to heterogeneous oil and gas production regions across geographies to obtain accurate regional emission estimates. Additionally, we characterize emissions relative to the fraction of a facility's total methane throughput; an effective metric to identify sites with excess emissions resulting from avoidable operating conditions, such as malfunctioning equipment (defined here as functional super-emitters). This work suggests that identifying functional super-emitters and correcting their avoidable operating conditions would result in significant emission reductions. However, due to their spatiotemporal dynamic behavior, achieving and maintaining uniformly low emissions across the entire population of sites will require mitigation steps (e.g. leak detection

  14. The Superconducting Super Collider: A status report

    Energy Technology Data Exchange (ETDEWEB)

    Schwitters, R.F.

    1993-04-01

    The design of the Superconducting Super Collider (SSC) is briefly reviewed, including its key machine parameters. The scientific objectives are twofold: (1) investigation of high-mass, low-rate, rare phenomena beyond the standard model; and (2) investigation of processes within the domain of the standard model. Machine luminosity, a key parameter, is a function of beam brightness and current, and it must be preserved through the injector chain. Features of the various injectors are discussed. The superconducting magnet system is reviewed in terms of model magnet performance, including the highly successful Accelerator System String Test Various magnet design modifications are noted, reflecting minor changes in the collider arcs and improved installation procedures. The paper concludes with construction scenarios and priority issues for ensuring the earliest collider commissioning.

  15. Super-Resonant Intracavity Coherent Absorption

    CERN Document Server

    Malara, P; Giorgini, A; Avino, S; De Natale, P; Gagliardi, G

    2016-01-01

    The capability of optical resonators to extend the effective radiation-matter interaction length originates from a multipass effect, hence is intrinsically limited by the resonator quality factor. Here, we show that this constraint can be overcome by combining the concepts of resonant interaction and coherent perfect absorption. We demonstrate and investigate super-resonant coherent absorption in a coupled Fabry-Perot-ring cavity structure. At the FP resonant wavelengths, the described phenomenon gives rise to split modes with a nearly-transparent peak and a peak whose transmission is exceptionally sensitive to the intracavity loss. For small losses, the effective interaction pathlength of these modes is proportional respectively to the ratio and the product of the individual finesse coefficients of the two resonators. The results presented extend the conventional definition of resonant absorption and point to a way of circumventing the technological limitations of ultrahigh-quality resonators in spectroscopy...

  16. Structural behaviour of super-light structures

    DEFF Research Database (Denmark)

    Bagger, Anne; Hertz, Kristian Dahl

    2010-01-01

    with a lighter and softer material, such as lightweight concrete. The combined use of stiff and light material in SLS results in structures of high stiffness and low weight. The applied technology and the advantages of SLS are elaborated upon in [1] in these proceedings. The present paper focuses......A new structural concept, called Super-light Structures (SLS), has recently been invented and patented at the Technical University of Denmark. The basic concept of SLS is to construct a skeleton of a stiff and strong material, such as ordinary or high strength concrete, and stabilize this skeleton...... on the structural correlation between the stiff material and the light material. The shape of the skeleton can be optimized for the primary load on the structure, and it will take up the majority of the load. The lighter material forms the outer geometry of the structural component (e.g. a wall), and has several...

  17. SuperDARN scalar radar equations

    CERN Document Server

    Berngardt, O I; Potekhin, A P

    2016-01-01

    The quadratic scalar radar equations are obtained for SuperDARN radars that are suitable for the analysis and interpretation of experimental data. The paper is based on a unified approach to the obtaining radar equations for the monostatic and bistatic sounding with use of hamiltonian optics and ray representation of scalar Green's function and without taking into account the polarization effects. The radar equation obtained is the sum of several terms corresponding to the propagation and scattering over the different kinds of trajectories, depending on their smoothness and the possibility of reflection from the ionosphere. It is shown that the monostatic sounding in the media with significant refraction, unlike the case of refraction-free media, should be analyzed as a combination of monostatic and bistatic scattering. This leads to strong dependence of scattering amplitude on background ionospheric density due to focusing mechanism and appearance of new (bistatic) areas of effective scattering with signific...

  18. Solar neutrino results from Super-Kamiokande

    CERN Document Server

    Takeuchi, Y

    2001-01-01

    Latest Super-Kamiokande results of the solar neutrino flux, day/night results, energy spectrum measurements, and oscillation analyses are reported. The observation period spans May 31, 1996 to April 24, 2000, which corresponds to a detector live time of 1117 days. Our preliminary results indicate 1.3 sigma difference between day and night flux, and the energy spectrum expressed as data/(BP98 SSM) is consistent with a flat spectrum with chi /sup 2//D.O.F. = 13.7/17. Comparing global-flux oscillation analysis and SK day and night spectra, MSW SMA region, Just-So region and 2-flavor sterile solutions are disfavored at 95% C.L.

  19. Supermassive blackholes without super Eddington accretion

    Science.gov (United States)

    Christian, Damian Joseph; Kim, Matt I.; Garofalo, David; D'Avanzo, Jaclyn; Torres, John

    2017-08-01

    We explore the X-ray luminosity function at high redshift for active galactic nuclei using an albeit simplified model for mass build-up using a combination of mergers and mass accretion in the gap paradigm (Garofalo et al. 2010). Using a retrograde-dominated configuration we find an interesting low probability channel for the growth of one billion solar mass black holes within hundreds of millions of years of the big bang without appealing to super Eddington accretion (Kim et al. 2016). This result is made more compelling by the connection between this channel and an end product involving active galaxies with FRI radio morphology but weaker jet powers in mildly sub-Eddington accretion regimes. We will discuss our connection between the unexplained paucity of a given family of AGNs and the rapid growth of supermassive black holes, two heretofore seemingly unrelated aspects of the physics of AGNs that will help further understand their properties and evolution.

  20. Conformal anomaly of super Wilson loop

    CERN Document Server

    Belitsky, A V

    2012-01-01

    Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well-defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in ...

  1. The Super-B project accelerator status

    CERN Document Server

    Biagini, M.E.; Boni, R; Boscolo, M; Demma, T; Drago, A; Esposito, M; Guiducci, S; Marcellini, F; Mazzitelli, G; Preger, M; Raimondi, P; Sanelli, C; Serio, M; Stecchi, A; Stella, A; Tomassini, S; Zobov, M; Bertsche, K; Brachmann, A; Cai, Y; Chao, A; DeLira, A; Donald, M; Fisher, A; Kharakh, D; Krasnykh, A; Li, N; MacFarlane, D; Nosochkov, Y; Novokhatski, A; Pivi, M.; Seeman, J; Sullivan, M; Wienands, U; Weisend, J; Wittmer, W; Koop, I; Levichev, E; Nikitin, S; Piminov, P; Sinyatkin, S; Shatilov, D; Bolzon, B; Brunetti, L; Jeremie, A; Baylac, M; DeConto, J M; Gomez, Y; Meot, F; Monseu, N; Tourres, D; Bonis, J.; Chehab, R; Le Meur, G; Mercier, B; Poirier, F; Prevost, C; Rimbault, C; Touze, F; Variola, A; Chance, A; Napoly, O; Bosi, F; Liuzzo, S; Paoloni, E; Bettoni, S

    2010-01-01

    The SuperB project is an international effort aiming at building in Italy a very high luminosity e+e- (1036 cm-2 sec-1) asymmetric collider at the Y(4S) energy in the cm. The accelerator design has been extensively studied and changed during the past year. The present design, based on the new collision scheme, with large Piwinski angle and the use of “crab waist” sextupoles already successfully tested at the DANE -Factory at LNF Frascati, provides larger flexibility, better dynamic aperture and spin manipulation sections in the Low Energy Ring (LER) for longitudinal polarization of the electron beam at the Interaction Point (IP). The Interaction Region (IR) has been further optimized in terms of apertures and reduced backgrounds in the detector. The injector complex design has been also updated. A summary of the project status will be presented in this paper

  2. Super-relativity in the quantum theory

    CERN Document Server

    Leifer, P

    2007-01-01

    The relativity to the measuring device in quantum theory, i.e. the covariance of local dynamical variables relative transformations to moving quantum reference frame in Hilbert space, may be achieved only by the rejection of super-selection rule. In order to avoid the subjective nuance, I emphasis that the notion of "measurement" here, is nothing but the covariant differentiation procedure in the functional quantum phase space $CP(N-1)$, having pure objective sense of evolution. Transition to the local moving quantum reference frame leads to some particle-like solutions of quasi-linear field PDE in the dynamical space-time. Thereby, the functionally covariant quantum dynamics gives the perspective to unify the Einstein relativity and quantum principles which are obviously contradictable under the standard approaches.

  3. Super Wilson Loops and Holonomy on Supermanifolds

    CERN Document Server

    Groeger, Josua

    2013-01-01

    The classical Wilson loop is the gauge-invariant trace of the parallel transport around a closed path with respect to a connection on a vector bundle over a smooth manifold. We build a precise mathematical model of the super Wilson loop, an extension introduced by Mason-Skinner and Caron-Huot, by endowing the objects occurring with auxiliary Gra{\\ss}mann generators coming from S-points. A key feature of our model is a supergeometric parallel transport, which allows for a natural notion of holonomy on a supermanifold as a Lie group valued functor. Our main results for that theory comprise an Ambrose-Singer theorem as well as a natural analogon of the holonomy principle. Finally, we compare our holonomy functor with the holonomy supergroup introduced by Galaev in the common situation of a topological point. It turns out that both theories are different, yet related in a sense made precise.

  4. 纽曼MOMO-SUPER CARD

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    机身更薄不仅带来携带方面的优势,同时站在当今审美学的角度上也是趋势所在。机身仅有6.5毫米厚的纽曼MOMO-SUPER CARD几乎可以轻松放入你的钱包夹层中。其简洁的外观设计与苹果iPod有着异曲同工之妙,而永恒的纯黑色面板结合底部高抛光金属底壳,成为科技与艺术的完美结合体。

  5. A NOVEL SUPER-RESOLUTION BEAMFORMING ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Guo Li; Guo Yan; Li Ning

    2007-01-01

    A novel simply-structured hybrid smart antenna system suitable to be used in ad-hoc network terminals is proposed in this letter.The super-resolution beamforming algorithm is also presented based on the system using DOA estimation results.The algorithm can switch the beamforming to the direction of the expected signal and get the best transmitting performance after the pre-beamforming of the Butler matrix.The shifting value formulas are presented to obtain the best SNR when there is no interfering signal and to acquire the highest Signal to Interference Ratio(SIR)as there is one interfering signal.When there are more than one interfering signals,the pre-beamforming feature of the Butler matrix Can also suppress the interfering signals.Simulation results verified the algorithm.

  6. The JASMIN super-data-cluster

    CERN Document Server

    Lawrence, B N; Churchill, J; Juckes, M; Kershaw, P; Oliver, P; Pritchard, M; Stephens, A

    2012-01-01

    The JASMIN super-data-cluster is being deployed to support the data analysis requirements of the UK and European climate and earth system modelling community. Physical colocation of the core JASMIN resource with significant components of the facility for Climate and Environmental Monitoring from Space (CEMS) provides additional support for the earth observation community, as well as facilitating further comparison and evaluation of models with data. JASMIN and CEMS together centrally deploy 9.3 PB of storage - 4.6 PB of Panasas fast disk storage alongside the STFC Atlas Tape Store. Over 370 computing cores provide local computation. Remote JASMIN resources at Bristol, Leeds and Reading provide additional distributed storage and compute configured to support local workflow as a stepping stone to using the central JASMIN system. Fast network links from JASMIN provide reliable communication between the UK supercomputers MONSooN (at the Met Office) and HECToR (at the University of Edinburgh). JASMIN also supports...

  7. Super-Resonant Intracavity Coherent Absorption

    Science.gov (United States)

    Malara, P.; Campanella, C. E.; Giorgini, A.; Avino, S.; de Natale, P.; Gagliardi, G.

    2016-07-01

    The capability of optical resonators to extend the effective radiation-matter interaction length originates from a multipass effect, hence is intrinsically limited by the resonator’s quality factor. Here, we show that this constraint can be overcome by combining the concepts of resonant interaction and coherent perfect absorption (CPA). We demonstrate and investigate super-resonant coherent absorption in a coupled Fabry-Perot (FP)/ring cavity structure. At the FP resonant wavelengths, the described phenomenon gives rise to split modes with a nearly-transparent peak and a peak whose transmission is exceptionally sensitive to the intracavity loss. For small losses, the effective interaction pathlength of these modes is proportional respectively to the ratio and the product of the individual finesse coefficients of the two resonators. The results presented extend the conventional definition of resonant absorption and point to a way of circumventing the technological limitations of ultrahigh-quality resonators in spectroscopy and optical sensing schemes.

  8. Super-renormalizable and finite gravitational theories

    Energy Technology Data Exchange (ETDEWEB)

    Modesto, Leonardo, E-mail: lmodesto@fudan.edu.cn; Rachwał, Lesław, E-mail: rachwal@fudan.edu.cn

    2014-12-15

    We hereby introduce and extensively study a class of non-polynomial higher derivative theories of gravity that realize a ultraviolet (UV) completion of Einstein general relativity. These theories are unitary (ghost free) and at most only one-loop divergences survive. The outcome is a class of theories super-renormalizable in even dimension and finite in odd dimension. Moreover, we explicitly prove in D=4 that there exists an extension of the theory that is completely finite and all the beta functions vanish even at one-loop. These results can be easily extended in extra dimensions and it is likely that the higher dimensional theory can be made finite, too. Therefore we have the possibility for “finite quantum gravity” in any dimension.

  9. A Super-Resolution Laser Altimetry Concept

    Science.gov (United States)

    Lu, Xiaomei; Hu, Yongxiang; Trepte, Charles; Liu, Zhaoyan

    2014-01-01

    A super-resolution laser altimetry technique has been proposed to provide improved lidar altimetry from Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) lidar data, and it is applicable to other similar atmospheric profiling lidar with low-pass filters. To achieve high altimetry resolution, the new technique relies on an empirical relationship between the peak signal ratio and the distance between land surface and the peak signal range bin center, which is directly derived from the CALIPSO lidar measurements and does not require the CALIPSO's transient response. The CALIPSO surface elevation results in Northern America retrieved by the new technique agree with the National Elevation Database high resolution elevation maps, and the comparisons suggest that the precision of the technique is much better than 1.4 m. The preliminary data product of land surface elevation retrieved by the new technique from CALIPSO lidar measurements is available to the altimetry community for evaluation.

  10. Is Super-$B$ Sufficiently Superb? -- On the Motivation for a Super-$B$ Factory

    CERN Document Server

    Bigi, Ikaros I

    2004-01-01

    Despite the great success of the $\\Upsilon (4S)$ $B$ factories at KEK and SLAC and the guaranteed addition of high sensitivity measurements on beauty decays to be performed at the Tevatron and LHC, a strong case can be made for an $e^+e^-$ Super-$B$ factory yielding data samples of order $10^{10}$ $B \\bar B$ pairs as a necessity rather than luxury. It has to be justified through its ability to not only establish deviations from the Standard Model, but also diagnose and interpret those in terms of specific features of the New Dynamics. The role to be played by a Super-$B$ factory is thus analogous {\\em and even in parallel} to that of a linear collider. The latter's goal is to provide more detailed information on previously discovered New Physics involved in the electroweak phase transition. Likewise a Super-$B$ factory would provide precision probes for analyzing whether such New Dynamics has an impact on heavy flavour dynamics -- a need particularly manifest if the New Physics is housed under the `big tent' ...

  11. In vivo acoustic super-resolution and super-resolved velocity mapping using microbubbles.

    Science.gov (United States)

    Christensen-Jeffries, Kirsten; Browning, Richard J; Tang, Meng-Xing; Dunsby, Christopher; Eckersley, Robert J

    2015-02-01

    The structure of microvasculature cannot be resolved using standard clinical ultrasound (US) imaging frequencies due to the fundamental diffraction limit of US waves. In this work, we use a standard clinical US system to perform in vivo sub-diffraction imaging on a CD1, female mouse aged eight weeks by localizing isolated US signals from microbubbles flowing within the ear microvasculature, and compare our results to optical microscopy. Furthermore, we develop a new technique to map blood velocity at super-resolution by tracking individual bubbles through the vasculature. Resolution is improved from a measured lateral and axial resolution of 112 μm and 94 μ m respectively in original US data, to super-resolved images of microvasculature where vessel features as fine as 19 μm are clearly visualized. Velocity maps clearly distinguish opposing flow direction and separated speed distributions in adjacent vessels, thereby enabling further differentiation between vessels otherwise not spatially separated in the image. This technique overcomes the diffraction limit to provide a noninvasive means of imaging the microvasculature at super-resolution, to depths of many centimeters. In the future, this method could noninvasively image pathological or therapeutic changes in the microvasculature at centimeter depths in vivo.

  12. Super-telomeres in transformed human fibroblasts.

    Science.gov (United States)

    Chiodi, Ilaria; Belgiovine, Cristina; Zongaro, Samantha; Ricotti, Roberta; Horard, Beatrice; Lossani, Andrea; Focher, Federico; Gilson, Eric; Giulotto, Elena; Mondello, Chiara

    2013-08-01

    Telomere length maintenance is critical for organisms' long-term survival and cancer cell proliferation. Telomeres are kept within species-specific length ranges by the interplay between telomerase activity and telomeric chromatin organization. In this paper, we exploited telomerase immortalized human fibroblasts (cen3tel) that gradually underwent neoplastic transformation during culture propagation to study telomere composition and length regulation during the transformation process. Just after telomerase catalytic subunit (hTERT) expression, cen3tel telomeres shortened despite the presence of telomerase activity. At a later stage and concomitantly with transformation, cells started elongating telomeres, which reached a mean length greater than 100kb in about 900 population doublings. Super-telomeres were stable and compatible with cell growth and tumorigenesis. Telomere extension was associated with increasing levels of telomerase activity that were linked to the deregulation of endogenous telomerase RNA (hTERC) and exogenous telomerase reverse transcriptase (hTERT) expression. Notably, the increase in hTERC levels paralleled the increase in telomerase activity, suggesting that this subunit plays a role in regulating enzyme activity. Telomeres ranging in length between 10 and more than 100kb were maintained in an extendible state although TRF1 and TRF2 binding increased with telomere length. Super-telomeres neither influenced subtelomeric region global methylation nor the expression of the subtelomeric gene FRG1, attesting the lack of a clear-cut relationship between telomere length, subtelomeric DNA methylation and expression in human cells. The cellular levels of the telomeric proteins hTERT, TRF1, TRF2 and Hsp90 rose with transformation and were independent of telomere length, pointing to a role of these proteins in tumorigenesis.

  13. Super-virtual refraction interferometry: Theory

    KAUST Repository

    Bharadwaj, Pawan

    2011-01-01

    Inverting for the subsurface velocity distribution by refraction traveltime tomography is a well-accepted imaging method by both the exploration and earthquake seismology communities. A significant drawback, however, is that the recorded traces become noisier with increasing offset from the source position, and so prevents accurate picking of traveltimes in far-offset traces. To enhance the signal-to-noise ratio of the far-offset traces, we present the theory of super-virtual refraction interferometry where the signal-to-noise ratio (SNR) of far-offset head-wave arrivals can be theoretically increased by a factor proportional to N; here, N is the number of receiver and source positions associated with the recording and generation of the head-wave arrival. There are two steps to this methodology: correlation and summation of the data to generate traces with virtual head-wave arrivals, followed by the convolution of the data with the virtual traces to create traces with super-virtual head-wave arrivals. This method is valid for any medium that generates head-wave arrivals. There are at least three significant benefits to this methodology: 1). enhanced SNR of far-offset traces so the first-arrival traveltimes of the noisy far-offset traces can be more reliably picked to extend the useful aperture of data, 2). the SNR of head waves in a trace that arrive after the first arrival can be enhanced for accurate traveltime picking and subsequent inversion by traveltime tomography, and 3). common receiver-pair gathers can be analyzed to detect the presence of diving waves in the first arrivals, which can be used to assess the nature of the refracting boundary. © 2011 Society of Exploration Geophysicists.

  14. Super-strong magneto-rheological fluids

    Science.gov (United States)

    Tao, R.

    2001-03-01

    A typical MR fluid is a suspension of magnetic particles of micrometer size in a liquid. Upon application of a strong magnetic field, the fluid turns into a solid. This process is reversible and the response time is of milliseconds. MR fluids presently have a yield shear stress around 80 kPa, which is adequate for applications in shock absorbers and vibration dampers, but is inadequate for automobile clutch etc. Efforts in searching for new materials in the past decades came with limited results. Thus we have developed a new approach to change the microstructure of MR fluids and make them super-strong. It is well known that under a strong magnetic field, the ideal structure of MR fluids is a body-centered tetragonal (bct) lattice. The mechanical strength of MR fluids strongly depends on the microstructure. A bct-lattice based thick column has a much higher yield stress than a single-chain structure. When a magnetic field is applied to a MR fluid, the particles first form chains. With time, the chains may aggregate into columns. However, the unassisted aggregation is not very useful, as it is slow and produces columns with a limited thickness. Our method is based on assisted aggregations. Immediately after a magnetic field is applied, we compress the MR fluid in the field direction before a shear force is applied. The compression pushes the induced chains together to form thick columns. This microstructure change greatly enhances the yield stress. The experiment on an iron-based MR fluid finds 800 kPa for the yield stress, ten times stronger than that without the compression. When the magnetic field is removed, the MR fluid still returns to the liquid state quickly. The upper limit of this structure-enhanced yield stress seems well above 800 kPa. The super-strong MR fluids are suitable for many industrial applications. *Supported by NSF Grant 0196022

  15. Fixed Point Curve for Weakly Inward Contractions and Approximate Fixed Point Property

    Institute of Scientific and Technical Information of China (English)

    P. Riyas; K. T. Ravindran

    2013-01-01

    In this paper, we discuss the concept of fixed point curve for linear interpo-lations of weakly inward contractions and establish necessary condition for a nonex-pansive mapping to have approximate fixed point property.

  16. VAT and Fixed Establishment : Mysteries Solved?

    NARCIS (Netherlands)

    M.L. Schippers (Martijn); Boender, J.M.B.

    2015-01-01

    markdownabstractThe Sixth Value Added Tax (VAT) Directive introduced the concept of the fixed establishment in VAT. For a long time, the criteria for classifying activities as a fixed establishment seemed relatively clear. However the introduction in 2011 of the VAT Implementing Regulation3

  17. Approximate Equilibrium Problems and Fixed Points

    Directory of Open Access Journals (Sweden)

    H. Mazaheri

    2013-01-01

    Full Text Available We find a common element of the set of fixed points of a map and the set of solutions of an approximate equilibrium problem in a Hilbert space. Then, we show that one of the sequences weakly converges. Also we obtain some theorems about equilibrium problems and fixed points.

  18. On computing fixed points for generalized sandpiles

    OpenAIRE

    Formenti, Enrico; Masson, Benoît

    2004-01-01

    Presented at DMCS 2004 (Turku, FINLAND). Long version with proofs published in International Journal of Unconventional Computing, 2006; International audience; We prove fixed points results for sandpiles starting with arbitrary initial conditions. We give an effective algorithm for computing such fixed points, and we refine it in the particular case of SPM.

  19. Fixed-Response Questions with a Difference.

    Science.gov (United States)

    Johnstone, Alex H.; Ambusaidi, Abdullah

    2002-01-01

    Offers three types of fixed-response questions that are designed to overcome drawbacks appearing in the conventional forms of fixed-response questions such as not allowing the examiner to investigate reasoning, background, or prevent guessing. (Contains 14 references.) (Author/YDS)

  20. Approximate fixed point of Reich operator

    Directory of Open Access Journals (Sweden)

    M. Saha

    2013-01-01

    Full Text Available In the present paper, we study the existence of approximate fixed pointfor Reich operator together with the property that the ε-fixed points are concentrated in a set with the diameter tends to zero if ε $to$ > 0.

  1. Stabilising springs for fixed lingual retainer.

    Science.gov (United States)

    Karthikeyan, M K; Ramachandraprabhakar; Saravanan, R; Rajvikram, N; Kuppuchamy

    2013-11-01

    Most treated malocclusion needs fixed lingual retention. To stabilise fixed lingual retainer in the exact location needs proper stabilisation. Proper stabilization requires a holding spring. This Stabilising Spring should be easy to fabricate and help the clinician to stabilise the retainer quickly and save the chair side time. More over it should not irritate the mucosa and should be easy to insert and remove.

  2. Magnetic Fixed Points and Emergent Supersymmetry

    DEFF Research Database (Denmark)

    Antipin, Oleg; Mojaza, Matin; Pica, Claudio;

    2013-01-01

    We establish in perturbation theory the existence of fixed points along the renormalization group flow for QCD with an adjoint Weyl fermion and scalar matter reminiscent of magnetic duals of QCD [1-3]. We classify the fixed points by analyzing their basin of attraction. We discover that among the...

  3. Fixed-Response Questions with a Difference.

    Science.gov (United States)

    Johnstone, Alex H.; Ambusaidi, Abdullah

    2002-01-01

    Offers three types of fixed-response questions that are designed to overcome drawbacks appearing in the conventional forms of fixed-response questions such as not allowing the examiner to investigate reasoning, background, or prevent guessing. (Contains 14 references.) (Author/YDS)

  4. Polarization discrimination between repeater false-target and radar target

    Institute of Scientific and Technical Information of China (English)

    SHI LongFei; WANG XueSong; XIAO ShunPing

    2009-01-01

    High fidelity repeater false-target badly affects a radar system's detecting, tracking, and data processing. It is an available approach of confronting false-target for radar that discriminates firstly and then eliminates. Whereas for the technique progress about the repeater false-target jam, it is more and more difficult to discriminate this jam in the time-domain, frequency-domain, or space-domain. The technique using polarization information to discriminate the target and false-target is discussed in this paper. With the difference that false-target signal vector's polarization ratio is fixed and target echo signal vector's polarization ratio is variational along with radar transmission signal's polarization, we transform the discrimination problem to beeline distinguish problem in the 2-dim complex space. The distributing characteristic expression of the false-target discrimination statistic is constructed, with which the discrimination ratio of false-target is analyzed. For the target case, the decomposed model of target scattering matrix and the concept of distinguish quantity are proposed. Then, the discrimination ratio of target can be forecasted according to target distinguish quantity. Thus, the performance of discrimination method has been analyzed integrally. The simulation results demonstrate the method in this paper is effective on the discrimination of target and false-target.

  5. Current limitations in super-resolution fluorescence microscopy for biological specimens: How deep can we go from the cover glass?

    Science.gov (United States)

    Okada, Yasushi

    2017-04-01

    Diffraction limit of resolution has been one of the biggest limitations in the optical microscopy. Super-resolution fluorescence microscopy has enabled us to break this limit. However, for the observations of real biological specimens, especially for the imaging of tissues or whole body, the target structures of interest are often embedded deep inside the specimen. Here, we would present our results to extend the target of the super-resolution microscopy deeper into the cells. Confocal microscope optics work effectively to minimize the effect by the aberrations by the cellular components, but at the expense of the signal intensities. Spherical aberrations by the refractive index mismatch between the cellular environment and the immersion liquid can be much larger, but can be reduced by adjusting the correction collar at the objective lens.

  6. Three-dimensional super-wideband micro-antenna for high-resolution millimeter-wave medical imaging.

    Science.gov (United States)

    Mirbeik, Amir; Tavassoli, Vahid; Ayazi, Farrokh; Tavassolian, Negar

    2014-01-01

    This paper reports on a novel super-wideband micro-hemispherical antenna with application in millimeter-wave medical imaging. The antenna is composed of a hemispherical shell suspended above a substrate and can be fabricated using a fabrication technology originally developed for micron-scale electromechanical resonators. The antenna exhibits a wide fractional bandwidth of more than 80% (from 64 GHz to 150 GHz) and a high gain of 8.6 dBi at its center frequency. Radiation parameters of the antenna are characterized and the effect of its super-wideband behavior on pulsed millimeter-wave imaging is demonstrated. Finally, a preliminary array configuration composed of two antennas placed side-by-side in the vicinity of a skin-mimicking target is evaluated and the ability to fully detect the target has been demonstrated.

  7. Super Twisting Second Order Sliding Mode Control for Position Tracking Control of Hydraulic Drives

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben Ole; Pedersen, Henrik C.

    2013-01-01

    In this paper a control strategy based on second order sliding modes, generally applicable for position tracking control of electro-hydraulic valve-cylinder drives (VCD), is proposed. The main target is to overcome problems with linear controllers deteriorating performance due to the strong...... nonlinearities characterizing VCD's. The proposed controller requires pressure-, valve- and piston position measurements, and is based on the so-called super twisting algorithm and compensation of controlgain nonlinearities. Simulation results demonstrate strong robustness when subjected to large perturbations...

  8. A fast learning-based super-resolution method for copper strip defect image

    Science.gov (United States)

    Zhang, Zhuo; Fan, Xinnan; Zhang, Xuewu

    2017-07-01

    In this paper, a fast pre-classified-based super-resolution model has been proposed to overcome the problems of degraded imaging in weak-target real-time detection system, specialized to copper defect detection. To accurately characterize the defected image, textural features based on the statistical function of gray-gradient are presented. Furthermore, to improve the effectiveness and practicality of the online detection, a concept of pre-classified learning is introduced and an edge smoothness rule is designed. Some experiments are carried out on defect images in different environments and the experimental results show the efficiency and effectiveness of the algorithm.

  9. Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

    Science.gov (United States)

    Petersen, Romina; Lambourne, John J; Javierre, Biola M; Grassi, Luigi; Kreuzhuber, Roman; Ruklisa, Dace; Rosa, Isabel M; Tomé, Ana R; Elding, Heather; van Geffen, Johanna P; Jiang, Tao; Farrow, Samantha; Cairns, Jonathan; Al-Subaie, Abeer M; Ashford, Sofie; Attwood, Antony; Batista, Joana; Bouman, Heleen; Burden, Frances; Choudry, Fizzah A; Clarke, Laura; Flicek, Paul; Garner, Stephen F; Haimel, Matthias; Kempster, Carly; Ladopoulos, Vasileios; Lenaerts, An-Sofie; Materek, Paulina M; McKinney, Harriet; Meacham, Stuart; Mead, Daniel; Nagy, Magdolna; Penkett, Christopher J; Rendon, Augusto; Seyres, Denis; Sun, Benjamin; Tuna, Salih; van der Weide, Marie-Elise; Wingett, Steven W; Martens, Joost H; Stegle, Oliver; Richardson, Sylvia; Vallier, Ludovic; Roberts, David J; Freson, Kathleen; Wernisch, Lorenz; Stunnenberg, Hendrik G; Danesh, John; Fraser, Peter; Soranzo, Nicole; Butterworth, Adam S; Heemskerk, Johan W; Turro, Ernest; Spivakov, Mikhail; Ouwehand, Willem H; Astle, William J; Downes, Kate; Kostadima, Myrto; Frontini, Mattia

    2017-07-13

    Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to determine the mechanisms underpinning variant association with platelet quantitative traits using cell type-matched epigenomic data and promoter long-range interactions. We identify potential regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and we demonstrate, through ex vivo and proof of principle genome editing validation, that variants in super enhancers play an important role in controlling archetypical platelet functions.

  10. Fixed points of occasionally weakly biased mappings

    Directory of Open Access Journals (Sweden)

    Y. Mahendra Singh, M. R. Singh

    2012-09-01

    Full Text Available Common fixed point results due to Pant et al. [Pant et al., Weak reciprocal continuity and fixed point theorems, Ann Univ Ferrara, 57(1, 181-190 (2011] are extended to a class of non commuting operators called occasionally weakly biased pair[ N. Hussain, M. A. Khamsi A. Latif, Commonfixed points for JH-operators and occasionally weakly biased pairs under relaxed conditions, Nonlinear Analysis, 74, 2133-2140 (2011]. We also provideillustrative examples to justify the improvements. Abstract. Common fixed point results due to Pant et al. [Pant et al., Weakreciprocal continuity and fixed point theorems, Ann Univ Ferrara, 57(1, 181-190 (2011] are extended to a class of non commuting operators called occasionally weakly biased pair[ N. Hussain, M. A. Khamsi A. Latif, Common fixed points for JH-operators and occasionally weakly biased pairs under relaxed conditions, Nonlinear Analysis, 74, 2133-2140 (2011]. We also provide illustrative examples to justify the improvements.

  11. The price of fixed income market volatility

    CERN Document Server

    Mele, Antonio

    2015-01-01

    Fixed income volatility and equity volatility evolve heterogeneously over time, co-moving disproportionately during periods of global imbalances and each reacting to events of different nature. While the methodology for options-based "model-free" pricing of equity volatility has been known for some time, little is known about analogous methodologies for pricing various fixed income volatilities. This book fills this gap and provides a unified evaluation framework of fixed income volatility while dealing with disparate markets such as interest-rate swaps, government bonds, time-deposits and credit. It develops model-free, forward looking indexes of fixed-income volatility that match different quoting conventions across various markets, and uncovers subtle yet important pitfalls arising from naïve superimpositions of the standard equity volatility methodology when pricing various fixed income volatilities. The ultimate goal of the authors´ efforts is to make interest rate volatility standardization a valuable...

  12. Magnetic Fixed Points and Emergent Supersymmetry

    CERN Document Server

    Antipin, Oleg; Pica, Claudio; Sannino, Francesco

    2011-01-01

    We establish the existence of fixed points for certain gauge theories candidate to be magnetic duals of QCD with one adjoint Weyl fermion. In the perturbative regime of the magnetic theory the existence of a very large number of fixed points is unveiled. We classify them by analyzing their basin of attraction. The existence of several nonsupersymmetric fixed points for the magnetic gauge theory lends further support towards the existence of gauge-gauge duality beyond supersymmetry. We also discover that among these very many fixed points there are supersymmetric ones emerging from a generic nonsupersymmetric renormalization group flow. We therefore conclude that supersymmetry naturally emerges as a fixed point theory from a nonsupersymmetric Lagrangian without the need for fine-tuning of the bare couplings. Our results suggest that supersymmetry can be viewed as an emergent phenomenon in field theory. In particular there should be no need for fine-tuning the bare couplings when performing Lattice simulations ...

  13. Fluorescence in situ hybridization applications for super-resolution 3D structured illumination microscopy.

    Science.gov (United States)

    Markaki, Yolanda; Smeets, Daniel; Cremer, Marion; Schermelleh, Lothar

    2013-01-01

    Fluorescence in situ hybridization on three-dimensionally preserved cells (3D-FISH) is an efficient tool to analyze the subcellular localization and spatial arrangement of targeted DNA sequences and RNA transcripts at the single cell level. 3D reconstructions from serial optical sections obtained by confocal laser scanning microscopy (CLSM) have long been considered the gold standard for 3D-FISH analyses. Recent super-resolution techniques circumvent the diffraction-limit of optical resolution and have defined a new state-of-the-art in bioimaging. Three-dimensional structured illumination microscopy (3D-SIM) represents one of these technologies. Notably, 3D-SIM renders an eightfold improved volumetric resolution over conventional imaging, and allows the simultaneous visualization of differently labeled target structures. These features make this approach highly attractive for the analysis of spatial relations and substructures of nuclear targets that escape detection by conventional light microscopy. Here, we focus on the application of 3D-SIM for the visualization of subnuclear 3D-FISH preparations. In comparison with conventional fluorescence microscopy, the quality of 3D-SIM data is dependent to a much greater extent on the optimal sample preparation, labeling and acquisition conditions. We describe typical problems encountered with super-resolution imaging of in situ hybridizations in mammalian tissue culture cells and provide optimized DNA-/(RNA)-FISH protocols including combinations with immunofluorescence staining (Immuno-FISH) and DNA replication labeling using click chemistry.

  14. Projected sensitivity of the SuperCDMS SNOLAB experiment

    Energy Technology Data Exchange (ETDEWEB)

    Agnese, R.; Anderson, A. J.; Aramaki, T.; Arnquist, I.; Baker, W.; Barker, D.; Basu Thakur, R.; Bauer, D. A.; Borgland, A.; Bowles, M. A.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Calkins, R.; Cartaro, C.; Cerdeño, D. G.; Chagani, H.; Chen, Y.; Cooley, J.; Cornell, B.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Esteban, L.; Fallows, S.; Figueroa-Feliciano, E.; Fritts, M.; Gerbier, G.; Ghaith, M.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hofer, T.; Holmgren, D.; Hong, Z.; Hoppe, E.; Hsu, L.; Huber, M. E.; Iyer, V.; Jardin, D.; Jastram, A.; Kelsey, M. H.; Kennedy, A.; Kubik, A.; Kurinsky, N. A.; Leder, A.; Loer, B.; Lopez Asamar, E.; Lukens, P.; Mahapatra, R.; Mandic, V.; Mast, N.; Mirabolfathi, N.; Moffatt, R. A.; Morales Mendoza, J. D.; Orrell, J. L.; Oser, S. M.; Page, K.; Page, W. A.; Partridge, R.; Pepin, M.; Phipps, A.; Poudel, S.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Roberts, A.; Robinson, A. E.; Rogers, H. E.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Serfass, B.; Speller, D.; Stein, M.; Street, J.; Tanaka, H. A.; Toback, D.; Underwood, R.; Villano, A. N.; von Krosigk, B.; Welliver, B.; Wilson, J. S.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, X.; Zhao, X.

    2017-04-07

    SuperCDMS SNOLAB will be a next-generation experiment aimed at directly detecting low-mass (< 10 GeV/c$^2$) particles that may constitute dark matter by using cryogenic detectors of two types (HV and iZIP) and two target materials (germanium and silicon). The experiment is being designed with an initial sensitivity to nuclear recoil cross sections ~ 1 x 10$^{-43}$ cm$^2$ for a dark matter particle mass of 1 GeV/c$^2$, and with capacity to continue exploration to both smaller masses and better sensitivities. The phonon sensitivity of the HV detectors will be sufficient to detect nuclear recoils from sub-GeV dark matter. A detailed calibration of the detector response to low energy recoils will be needed to optimize running conditions of the HV detectors and to interpret their data for dark matter searches. Low-activity shielding, and the depth of SNOLAB, will reduce most backgrounds, but cosmogenically produced $^{3}$H and naturally occurring $^{32}$Si will be present in the detectors at some level. Even if these backgrounds are x10 higher than expected, the science reach of the HV detectors would be over three orders of magnitude beyond current results for a dark matter mass of 1 GeV/c$^2$. The iZIP detectors are relatively insensitive to variations in detector response and backgrounds, and will provide better sensitivity for dark matter particle masses (> 5 GeV/c$^2$). The mix of detector types (HV and iZIP), and targets (germanium and silicon), planned for the experiment, as well as flexibility in how the detectors are operated, will allow us to maximize the low-mass reach, and understand the backgrounds that the experiment will encounter. Upgrades to the experiment, perhaps with a variety of ultra-low-background cryogenic detectors, will extend dark matter sensitivity down to the "neutrino floor", where coherent scatters of solar neutrinos become a limiting background.

  15. Super-Eight: The brightest z~8 Galaxies

    Science.gov (United States)

    Holwerda, Benne; Bouwens, R.; Bradley, L.; Calvi, V.; Illingworth, G.; Labbe, I.; Magee, D.; Oesch, P.; Roberts-Borsani, G.; Smit, R.

    2016-08-01

    What are the properties of the most massive z~8 galaxies ('Super-Eights') and how luminous can these galaxies become at that epoch? Answering these questions is challenging due to the rarity of luminous z~8 galaxies and the large field-to-field variations in their volume densities. Indeed, the full wide-area CANDELS program only shows 3 z~8 galaxy candidates brighter than 25.5 mag and all of these candidates conspicuously lie in the same CANDELS field (EGS). One of our strongest new probes for particularly luminous z~8 galaxies are the WFC3 Pure-Parallel (PP) programs. Particularly intriguing are 8 bright z~8 candidates in these observations. These candidates have similar luminosities as the 3 brightest z~8 candidates from CANDELS (all spectroscopically confirmed). However, the uncertain contamination levels at extreme bright end of z~8 selection mean that follow-up observations are critical. We propose highly-efficient pointed HST and Spitzer/IRAC observations to determine if these candidates are indeed at z~8. We estimate that anywhere from 50 to 100% of the targeted sources will be confirmed to be at z~8 based on our results from CANDELS. The estimate is very uncertain due to very large cosmic variance in the CANDELS result and contamination from rare low-redshift sources. When combined with CANDELS, our observations would provide us the strongest current constraints on the volume density of bright, massive galaxies in the early Universe (serving as a guide to models of their build-up) and also provide valuable targets for future spectroscopy (e.g. with JWST), useful for probing the ionization state of the IGM.

  16. Analysis on Dry Matter Production Characteristics of Super Hybrid Rice

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Six middle-season indica hybrid rice combinations,including five super hybrid rice combinations with the high yield about 10.5 t/ha and a check hybrid rice combination Shanyou 63 with a yield potential about 9.5 t/ha,were used as materials to study the dry matter production characteristics.The super hybrid rice showed a high ability in dry matter production and accumulation and its yield enhanced with the increase of dry matter accumulation.The advantage period of dry matter production in the super hybrid rice was mainly at the middle and late growth stages compared with the check.The grain yield had no significant correlation with the dry matter accumulation before the elongation stage while had a significantly positive correlation with the dry matter accumulation from the elongation to maturity stages in super hybrid rice.There were more dry matter in vegetative organs at the heading stage in the super hybrid rice but its contribution to yield (apparent conversion percentage) was averagely 4.3 percent points lower than that in the check.For crop growth rate (CGR),the comparative advantage of super hybrid rice was at the middle and late stages,especially after flowering.Moreover,as the rising of leaf area index (LAI) and leaf area duration (LAD),CGR enhanced.The total LAD and the mean of LAD per day of super hybrid rice was about 14.79% and 10.31% higher than those of the check,respectively.The results indicate that the high yield of super hybrid rice mostly comes from the products of photosynthesis after heading,which is shown by the increased CGR at middle and later stages.It is suggested that LAD character might be used to better explain the advantage in the dry matter production of super hybrid rice than LAI.

  17. [Socio-ecological super-determination of health in rural areas in Humaitá, State of Amazonas, Brazil].

    Science.gov (United States)

    Schütz, Gabriel Eduardo; Mello, Marcia Gomide da Silva; de Carvalho, Marcia Aparecida Ribeiro; Câmara, Volney de Magalhães

    2014-10-01

    The scope of this article is to apply a trans-disciplinary socio-ecological approach to discuss the super-determination of health in rural areas of the southern Amazon region from a case study developed in Humaitá in the State of Amazonas in Brazil. Field data were collected using ethnographic techniques applied during three expeditions in Humaitá's rural area between 2012 and 2014. Based on the 'socio-ecological metabolism' analytical category, a descriptive and theoretical analysis of four crucial components in the process of super-determination of local health are presented: (1) the composition of the local rural population; (2) fixed and changing territorial aspects; (3) construction of socio-ecological identities; (4) ethnic conflict between Indians and non-Indians. The conclusion reached is that the incorporation of a socio-ecological approach in territorial-based health research provides input for analyses of the local health situation through the systematization of information related to the process of super-determination of health. It also helps in the construction of trans-disciplinarity, which is a necessary epistemological condition for addressing the complex reality at the interfaces of social production, the environment and health.

  18. Sectioning and super-resolution using unknown random patterns

    Science.gov (United States)

    Hoffman, Zachary R.; DiMarzio, Charles A.

    2016-03-01

    Random structured illumination patterns are used to demonstrate effective sectioning as well as super-resolution images in conjunction with an incoherent light source. By projecting patterns of varied spatial frequencies and using blind deconvolution of an unknown point spread function, super-resolution is achieved. Random patterns produce more consistent sectioning and super-resolution given an unknown optical transfer function. Further, using a randomly distributed pattern provides a low cost solution to obtaining information similar to that produced in confocal microscopy and other methods of structured illumination, without the requirement of precise projection patterns, coherent light sources, or fluorescence.

  19. Three dimensional super-resolution in metamaterial slab lenses

    CERN Document Server

    Mesa, F; Freire, M; Baena, J D

    2005-01-01

    This letter presents a theoretical and experimental study on the viability of obtaining three dimensional super-resolution (i.e. resolution overcoming the diffraction limit for all directions in space) by means of metamaterial slab lenses. Although the source field cannot be actually reproduced at the back side of the lens with super-resolution in all space directions, the matching capabilities of metamaterial slabs does make it possible the detection of images with three-dimensional super-resolution. This imaging takes place because of the coupling between the evanescent space harmonic components of the field generated at both the source and the detector.

  20. Representations Of The Super-virasoro Algebra fock Representations

    CERN Document Server

    Polychronidis, V J

    1999-01-01

    In this dissertation the complete classification of the Super- Virasoro modules M (h, c) of the Neveu-Schwarz and Ramond algebras is constructed. A family of representations F p, po of the Neveu- Schwarz and Ramond algebras, which generalize the Fock representations of the Virasoro algebra, is constructed. The Felder's construction of Fock space resolutions for the Virasoro minimal models is generalized in the Super-Virasoro minimal models case. In particular, a two-sided resolution of the irreducible Super-Verma module L( h, c) of the Neveu- Schwarz algebra is provided. --- 8 --- AN